title: Altered sensitivity to acetylcholine during chronic administration of organophosphorus anticholinesterase (fenthion) in albino mice.
abstract: Tissue sensitivity to acetylcholine during chronic administration of fenthion was assessed in mice. Fenthion was injected intra-muscularly every fourth day and experiments were carried out at various intervals. The parameters selected for testing cholinergic effects were, acetyl choline-induced contraction of isolated ileum and salivary secretion in vivo. In both types of experiments an initial supersensitivity followed by tolerance to acetylcholine  were observed. The underlying mechanisms are discussed.
mesh_terms: D000109:Acetylcholine / Q000494:pharmacology*; D000818:Animals; D004361:Drug Tolerance; D005284:Fenthion / Q000494:pharmacology*; D066298:In Vitro Techniques; D051379:Mice; D012472:Salivation / Q000187:drug effects
chemical_list: D005284:Fenthion; D000109:Acetylcholine