Cardiovascular and antiarrhythmic effects of aprindine (AC1802) during partial occlusion of a coronary artery in the pig.
The effect of intravenously administered aprindine (AC1802) as a prophylactic agent against ventricular arrhythmias was studied in pigs. During the first 30 min of ischaemia 5 of the 22 untreated animals died because of ventricular fibrillation against 1 of the 23 animals pretreated with aprindine (P=0.09). Ventricular tachycardias were observed in 10 untreated animals and in none of the aprindine group (P=0.0002). The incidence of other arrhythmias was significantly less in the aprindine group compared with the untreated group (P less than 0.02).
D000818:Animals; D001073:Aprindine / Q000008:administration & dosage*; D001145:Arrhythmias, Cardiac / Q000517:prevention & control*; D002245:Carbon Dioxide / Q000097:blood; D003327:Coronary Disease / Q000150:complications; D007192:Indenes / Q000008:administration & dosage*; D013552:Swine; D014693:Ventricular Fibrillation / Q000517:prevention & control
D007192:Indenes; D002245:Carbon Dioxide; D001073:Aprindine