Effect of starvation on excretion, distribution and metabolism of DDT in mice.
Effect of starvation on tissue radioactivity of 14C-DDT was examined in mice 8 days after its single injection. Animals were completely fasted and given barium sulfate by gastric intubation for the last 3 days. The findings obtained from starved mice were as follows: 1) loss of body weight, 2) decrease in organ weight of epedidymal fat and liver, 3) reduction in lipid content of whole body as well as of epididymal fat, 4) a marked elevation of DDT levels in tissues except muscle, and 5) occasional neurotoxidc signs characterized by tremors and convulsions. Excretion of DDT-related metabolites was not changed by starvation. Analysis of metabolic producets of 14C-DDT using thin-layer radiochromatography revealed that there was little or no significant difference between control and starved mice in the metabolic pattern of DDT-related compounds in the tissues and excreta. It was assumed the DDT-ingested animals with dietary energy restriction had a subsequent risk of toxicity resulted from redistribution of DDT, but not from alteration in excretion or metabolism.
D000273:Adipose Tissue / Q000032:analysis; D000818:Animals; D001466:Barium Sulfate; D001923:Brain Chemistry; D003634:DDT / Q000378:metabolism*; D005243:Feces / Q000032:analysis; D007668:Kidney / Q000033:anatomy & histology; D008099:Liver / Q000033:anatomy & histology; D008297:Male; D051379:Mice; D009132:Muscles / Q000032:analysis; D009929:Organ Size; D013154:Spleen / Q000033:anatomy & histology; D013217:Starvation / Q000378:metabolism*
D001466:Barium Sulfate; D003634:DDT