3-hydroxyisoxazole-5-hydroxamic acid.
The synthesis of the title compound, 3-hydroxyisoxazole-5-hydroxamic acid (4b), by two procedures is described. The first, involving the treatment of dimethyl acetylenedicarboxylate with hydroxylamine, had previously been reported to give the 3-hydroxyisoxazole-5-carboxylic acid (4a). In the second, treatment of chlorofumaroyl dichloride with hydroxylamine also gave the intermediate chlorofumarodihydroxamic acid (6). Compound 6 was found to have some activity against P388 lymphocytic leukemia.
D000818:Animals; D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents / Q000138:chemical synthesis; D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000627:therapeutic use; D001419:Bacteria / Q000187:drug effects; D005658:Fungi / Q000187:drug effects; D006877:Hydroxamic Acids / Q000138:chemical synthesis* / Q000494:pharmacology / Q000627:therapeutic use; D007555:Isoxazoles / Q000138:chemical synthesis* / Q000494:pharmacology / Q000627:therapeutic use; D007939:Leukemia L1210 / Q000188:drug therapy; D007942:Leukemia, Experimental / Q000188:drug therapy; D051379:Mice; D008826:Microbial Sensitivity Tests; D010080:Oxazoles / Q000138:chemical synthesis*
D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents; D000970:Antineoplastic Agents; D006877:Hydroxamic Acids; D007555:Isoxazoles; D010080:Oxazoles