Surgical removal of adipose tissue alters feeding behavior and the development of obesity in rats.
Lipectomized and sham-operated rats were fed a high-fat diet to induce hyperphagia and rapid fat accumulation. Lipectomized rats with 25% fewer adipocytes were less hyperphagic and accumulated less fat, but their adipocytes remained equal in size to adipocytes of controls. A role for adipocyte size in fat storage regulation and food intake control is postulated.
D000273:Adipose Tissue / Q000166:cytology / Q000502:physiology*; D000367:Age Factors; D000818:Animals; D004822:Epididymis; D005247:Feeding Behavior / Q000502:physiology*; D007264:Inguinal Canal; D008297:Male; D009765:Obesity / Q000209:etiology*; D051381:Rats