Oculomotor disturbances associated with 5-fluorouracil chemotherapy.
Two patients treated with 5-fluorouracil (5-FU) for disseminated adenocarcinoma of the colon developed cerebellar dysfunction typical of 5-FU neurotoxicity. The neurotoxicity was associated with oculomotor disturbances expressed primarily as weakness of convergence and divergence. Detailed postmortem examination of one patient revealed no anatomical abnormalities of the central nervous system. The ocular motor disturbances are probably an expression of regional 5-FU neurotoxicity primarily affecting the brain stem.
D000230:Adenocarcinoma / Q000188:drug therapy; D000328:Adult; D001933:Brain Stem / Q000187:drug effects; D002526:Cerebellar Diseases / Q000139:chemically induced; D003110:Colonic Neoplasms / Q000188:drug therapy; D005133:Eye Movements / Q000187:drug effects*; D005260:Female; D005472:Fluorouracil / Q000009:adverse effects* / Q000627:therapeutic use; D006801:Humans; D008297:Male; D009802:Oculomotor Nerve / Q000187:drug effects; D009886:Ophthalmoplegia / Q000139:chemically induced*
D005472:Fluorouracil