The effects of ketamine sedation and ketamine-pentobarbital anesthesia upon the intraocular pressure of the rabbit.
The effect of ketamine sedation and ketamine-pentobarbital anesthesia upon the intraocular pressure (IOP) of the rabbit was studied by applanation pneumatonography. Peak values of IOP during both ketamine sedation and ketamine-pentobarbital anesthesia were reached 3 to 5 minutes after administration of the drug(s). The peak IOP increase during ketamine sedation (10 mg./kg. IM) was 2.2 +/- 0.4 mm. Hg. The peak IOP increase with ketamine-pentobarbital anesthesia (50 mg./kg. ketamine IM + 30 mg./kg. pentobarbital IM) was 7.1 +/- 0.8 mm. Hg. Atropine premedication did not prevent the increase in IOP seen with ketamine sedation or ketamine-pentobarbital anesthesia.
D000768:Anesthesia, General; D000818:Animals; D001285:Atropine / Q000008:administration & dosage / Q000494:pharmacology; D007429:Intraocular Pressure / Q000187:drug effects*; D007649:Ketamine / Q000008:administration & dosage / Q000494:pharmacology*; D010424:Pentobarbital / Q000008:administration & dosage / Q000494:pharmacology*; D011229:Preanesthetic Medication; D011817:Rabbits
D007649:Ketamine; D001285:Atropine; D010424:Pentobarbital