[Neurochemical mechanisms of morphine action on the function of neurons in the midbrain reticular formation].
The effect of microiontophoretically applied morphine and its interactions with the effect of microiontophoretic applications of either acetylcholine (ACh) or 5-hydroxytryptamine (5-HT) were studied in single neurons of the midbrain RF in immobilized rats. Morphine altered the firing rate of the majority of neurons: 39% neurons were excited, 16%-inhibited. Morphine reduced or blocked reactions of most (67%) neurons to 5-HT but had no effect on their reactions to ACh (86% of neurons). The findings suggest that interaction between morphine and sezotoninergic structures of the brain plays a more important role in mechanism of morphine central action than the interaction between morphine and cholinergic systems.
D000109:Acetylcholine / Q000494:pharmacology; D000818:Animals; D004347:Drug Interactions; D007478:Iontophoresis; D008297:Male; D008636:Mesencephalon / Q000187:drug effects*; D009020:Morphine / Q000494:pharmacology*; D051381:Rats; D012154:Reticular Formation / Q000187:drug effects*; D012701:Serotonin / Q000494:pharmacology
D012701:Serotonin; D009020:Morphine; D000109:Acetylcholine
Izuchenie neĭrokhimicheskikh mekhanizmov deĭstviia morfina na funktsii neĭronov retikuliarnoĭ formatsii srednego mozga.