[Identification of kinins releasing by pig pancreatic kallikrein from rabbit low molecular weight kininogen].
Pig pancreatic kallikrein is found to release kinins from LMrK with the rate of 800 mkg. eq. of bradykinin per min, per 1 mg of the enzyme. This kininogenase reaction is not accompanied by a ddep fragmentation of the kininogen molecule, because only a high molecular weight fragment which Mr is practically equal to that of intact LMrK (55-60 000), and a peptide identified as bradykinin, are found in hydrolysate. In the same conditions human salivary kallikrein is found to form kallidin from LMrK.
D000818:Animals; D001920:Bradykinin / Q000378:metabolism; D006801:Humans; D007609:Kallidin / Q000378:metabolism; D007610:Kallikreins / Q000378:metabolism*; D007704:Kininogens / Q000378:metabolism*; D007705:Kinins / Q000378:metabolism*; D010179:Pancreas / Q000201:enzymology*; D010446:Peptide Fragments / Q000378:metabolism; D011817:Rabbits; D012463:Saliva / Q000201:enzymology; D013552:Swine
D007704:Kininogens; D007705:Kinins; D010446:Peptide Fragments; D007609:Kallidin; D007610:Kallikreins; D001920:Bradykinin
Identifikatsiia kininov, osvobozhdaemykh pankreaticheskim kallikreinom svin'i iz nizkomolekuliarnogo kininogena krolika.