Hepatic veno-occlusive disease due to pyrrolizidine (Senecio) poisoning in Arizona.
An infant with documented hepatic veno-occlusive disease due to ingestion of pyrrolizidine alkaloids is presented. The alkaloids were ingested in the form of an herbal tea commonly used as a folk remedy among the Mexican-American population. Among these people, this herb is known as gordolobo yerba. The patient presented with acute hepatocellular disease and portal hypertension which progressed over 2 months to extensive hepatic fibrosis. Other potential causes of hepatic venous occlusion were absent.
D056486:Chemical and Drug Induced Liver Injury / Q000178:diet therapy / Q000188:drug therapy / Q000473:pathology; D004912:Erythrocytes; D005260:Female; D005665:Furosemide / Q000627:therapeutic use; D006503:Hepatic Veins / Q000473:pathology; D006801:Humans; D007223:Infant; D008099:Liver / Q000473:pathology; D011763:Pyrrolizidine Alkaloids / Q000506:poisoning*; D012965:Sodium Chloride; D014689:Venous Insufficiency / Q000139:chemically induced
D011763:Pyrrolizidine Alkaloids; D012965:Sodium Chloride; D005665:Furosemide