title: Early diagnosis of myocardial infarction in the dog with 99mTc-glucoheptonate.
abstract: Early gamma imaging of acute experimental myocardial infarcts was evaluated in mongrel dogs with 99mTc-glucoheptonate. From 15 to 20 mCi were injected between 1 and 27 hr after coronary artery occlusion. Nine dogs imaged 3 hr after injection (4 hr after occlusion) showed unequivocal uptake in the region of the infarct. Fifteen dogs imaged 5-7 hr after injection (6-8 hr after occlusion) showed sufficiently well-defined regions of abnormal uptake so that planimetry could be performed reliably. Five animals imaged serially showed improvement of the image only up to about 5-7 hr after injection. Infarct-to-normal myocardium and infarct-to-blood ratios were slightly higher in dogs injected 15-27 hr after infarction than in those injected 1 hr after infarction, implying that equally good results can be obtained with injection and imaging of 99mTc-glucoheptonate at any time within the first day. No other infarct-labeling radiopharmaceutical shares this capability for the early detection a delineation of acute infarcts.
mesh_terms: D000208:Acute Disease; D000818:Animals; D004285:Dogs; D006539:Heptoses; D009203:Myocardial Infarction / Q000175:diagnosis*; D009206:Myocardium / Q000378:metabolism; D011877:Radionuclide Imaging; D013400:Sugar Acids; D013667:Technetium; D013997:Time Factors
chemical_list: D006539:Heptoses; D013400:Sugar Acids; D013667:Technetium; C007852:alpha-glucoheptonic acid