[Studies on amino acid kinetics in rats without and with interference of the pregnancy using 75-Se-methionine (author's transl)].
A collective of 60 rats was divided into 3 groups of 20 non-pregnant, 20 pregnant without interference of the pregnancies and 20 pregant with ligature of the uterine vessels to induce an intrauterine growth retardation. The organ distribution of 100 muC intravenously injected 75-Se-methionine, which is actively transported from the placenta into the fetal circulation, was computer-scintigraphically measured. After 30 minutes and 6 hours typical differences, amongst the 3 groups, between the liver and foetoplacental unit methionine uptake were demonstrated both visually and quantitatively. On the basis of this experimental animal model, it should be attempted to measure quantitatively the placental disorders which are not caused primarily by perfusion of the uteroplacental unit.
D000818:Animals; D005260:Female; D007700:Kinetics; D008099:Liver / Q000378:metabolism; D008431:Maternal-Fetal Exchange; D010922:Placenta Diseases / Q000378:metabolism; D011247:Pregnancy; D011248:Pregnancy Complications / Q000378:metabolism*; D051381:Rats; D012643:Selenium / Q000378:metabolism*; D012645:Selenomethionine / Q000378:metabolism*
D012645:Selenomethionine; D012643:Selenium
Tierexperimentelle Untersuchungen zur Aminosäurekinetik bei ungestörter und gestörter Schwangerschaft mit 75-Se-Methionin.