Prostaglandin production by human polymorphnuclear leucocytes during phagocytosis in vitro.
Human polymorphonuclear leukocytes were found to be able to synthetize and release substantial amounts of PGE2' when stimulated by a phagocytic stimulus such as zymosan particles coated with complement. Hydrocortisone, at a concentration of 10(-5) M, which proved to be effective in other biological systems, failed to inhibit phagocytosis and PG release.
D006801:Humans; D066298:In Vitro Techniques; D009504:Neutrophils / Q000378:metabolism / Q000502:physiology*; D010587:Phagocytosis; D011458:Prostaglandins E / Q000096:biosynthesis*; D015054:Zymosan
D011458:Prostaglandins E; D015054:Zymosan