Heparin pretreatment suppresses norepinephrine concentrations in dogs in endotoxic shock.
Mongrel dogs were treated intravenously with either 1000 units of beef-lung heparin per kilogram of body weight or with isotonic saline, before intravenous administration of E. coli endotoxin. We found significant differences in circulating norepinephrine concentrations between a heparin-pretreatment group (1.89 +/- 0.39 microgram/liter) and the control group (9.83 +/- 4.64 microgram/liter), but none with respect to epinephrine. Systolic blood pressures at 360 min were also significantly (P less than 0.05) different, 148 +/- 6 mmHg as compared with 118 +/- 13.4 mmHg. Evidently heparin pretreatment can decrease circulating norepinephrine concentrations in the endotoxic state and changes in circulating catecholamine concentrations can affect physiological variables.
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D003864:Depression, Chemical; D004285:Dogs; D004837:Epinephrine / Q000097:blood; D006493:Heparin / Q000008:administration & dosage / Q000494:pharmacology*; D009638:Norepinephrine / Q000097:blood*; D012772:Shock, Septic / Q000097:blood* / Q000503:physiopathology; D013997:Time Factors
D006493:Heparin; D009638:Norepinephrine; D004837:Epinephrine