Prognostic significance of thrombocytosis in idiopathic sideroblastic anemia.
In order to determine the prognostic significance of thrombocytosis in idiopathic sideroblastic anemia, the clinical courses of 17 patients were reviewed. Six patients (36%) had thrombocytosis, and none developed acute leukemia. Nine patients (53%) had normal platelet counts, and one developed acute leukemia. Two patients (12%) were thrombocytopenic, and one died of acute leukemia. There was little correlation between survival and platelet count. Sixty-three additional case reports of idiopathic sideroblastic anemia were collected from the literature. Analysis of those patients and the patients in the present study documented transformation to acute leukemia in 5 of 9 (56%) thrombocytopenic patients, 4 of 54 (7.4%) patients with normal platelet counts, and 0 of 17 patients with thrombocytosis (p less than 0.05). Therefore patients with idiopathic sideroblastic anemia and thrombocytosis appear to have a decreased likelihood of leukemic transformation.
D000368:Aged; D000756:Anemia, Sideroblastic / Q000150:complications* / Q000188:drug therapy; D002471:Cell Transformation, Neoplastic; D004351:Drug Resistance; D005260:Female; D006801:Humans; D007938:Leukemia / Q000175:diagnosis*; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D011736:Pyridoxine / Q000627:therapeutic use; D013922:Thrombocytosis / Q000150:complications*
D011736:Pyridoxine