[Formation of a new antibiotic, nocamycin, by a culture of Nocardiopsis syringae sp. nov].
A culture of a new actinomycetous species, Nocardiopsis syrinage was isolated from a soil sample. The antibiotic produced by it was named nocamycin. It accumulated in the culture fluid on cultivation of the organism in a nutrient medium containing soybean meal, glycerin, sodium chloride and calcium carbonate. Crystalline nocamycin had an antitumor effect. In inhibited by 72--73 per cent the development of an intraperitoneally implanted lymphadenosis of strain NK/LI in mice.
D000191:Actinomycetaceae / Q000145:classification* / Q000378:metabolism; D000818:Animals; D000903:Antibiotics, Antineoplastic / Q000096:biosynthesis* / Q000494:pharmacology; D004353:Drug Evaluation, Preclinical; D008223:Lymphoma / Q000188:drug therapy; D051379:Mice; D008826:Microbial Sensitivity Tests; D009374:Neoplasms, Experimental / Q000188:drug therapy; D012988:Soil Microbiology
D000903:Antibiotics, Antineoplastic
Obrazovanie novogo antibiotika nokamitsina kul'turoĭ Nocardiopsis syringae sp. nov.