title: Effect of superoxide dismutase and succinate on the development of hyperbaric oxygen toxicity.
abstract: Prolonged exposure to hyperbaric O2 (HBO) causes seizures and eventual death. The precise molecular basis for O2 toxicity is not known but may be due to increased biological production of superoxide anion (O2-). In the present study, superoxide dismutase (SOD), an enzyme that catalyzes the dismutation of O2- to less toxic forms, was evaluated for its ability to protect against HBO-induced seizures and death, and the results were compared to those concurrently obtained with succinate (SUCC), an agent previously reported to protect against HBO-induced seizures. Preconvulsion time and survival time in normal and vitamin E-deficient rats exposed to 100% O2 at 5 ATA were not significantly prolonged by pretreatment with 2 to 20 mg/kg SOD intraperitoneally (ip) or 0.1 to 1.0 mg/kg SOD intrathecally. In contrast, 12 mmol/kg SUCC ip significantly prolonged preconvulsion time in normal and vitamin E-deficient rats and survival time in normal rats. The ability of SUCC to stimulate ATP production may account for its protective role. Reasons for the failure of SOD to protect against O2 toxicity are discussed.
mesh_terms: D000818:Animals; D001274:Atmospheric Pressure; D008297:Male; D010100:Oxygen / Q000009:adverse effects*; D051381:Rats; D012640:Seizures / Q000139:chemically induced / Q000517:prevention & control; D013386:Succinates / Q000627:therapeutic use*; D013482:Superoxide Dismutase / Q000627:therapeutic use*; D013997:Time Factors; D014811:Vitamin E Deficiency / Q000503:physiopathology
chemical_list: D013386:Succinates; D013482:Superoxide Dismutase; D010100:Oxygen