Developmental patterns of plasma TSH, T4 and T3 in rats deprived of light from birth.
Plasma levels of TSH, T4 and T3 in the rat show characteristic developmental patterns within the first postnatal month, with TSH reaching a peak on day 13, T4 on day 16 and T3 on day 20. In dark-reared rats, a significant reduction in plasma T3 associated with low plasma T4 as well as high plasma TSH suggest that light-deprivation from birth impairs and/or delays maturation of pituitary-thyroid axis.
D000367:Age Factors; D000818:Animals; D003624:Darkness; D008297:Male; D051381:Rats; D013972:Thyrotropin / Q000097:blood*; D013974:Thyroxine / Q000097:blood*; D014284:Triiodothyronine / Q000097:blood*
D014284:Triiodothyronine; D013972:Thyrotropin; D013974:Thyroxine