[Study of the equilibrium conditions for the extractive purification of oleandomycin].
Dependence of the oleandomycin distribution coefficient on the antibiotic concentration, duration of the filtrate storage, extraction temperature and salting-out agents was studied. The distribution coefficient of oleandomycin in the system of fermentation broth filtrate--butylacetate was much lower (about 3 times) than that in the system of oleandomycin phosphate aqueous solution--butylacetate. Addition of sodium sulfate to the aqueous phase provided a significant increase in the oleandomycin distribution coefficient.
D000085:Acetates / Q000494:pharmacology; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D004305:Dose-Response Relationship, Drug; D004356:Drug Storage; D009827:Oleandomycin / Q000302:isolation & purification*; D012996:Solutions; D013431:Sulfates / Q000494:pharmacology; D013696:Temperature; D013997:Time Factors
D000085:Acetates; D012996:Solutions; D013431:Sulfates; D009827:Oleandomycin
Izuchenie usloviĭ ravnovesiia pri ékstraktsionnoĭ ochistke oleandomitsina.