title: An improved procedure for the synthesis of glycine and taurine conjugates of bile acids.
abstract: Glycine and taurine conjugates of 5beta-cholanic acids have been synthesized using improved procedures based on the peptide coupling reagent, N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline. The conjugates are obtained in chromatographically pure form in yields higher than 90%. The use of this procedure in the large scale preparation of cholyl[1,2-13C2]glycine is described.
mesh_terms: D001647:Bile Acids and Salts; D055598:Chemical Phenomena; D002621:Chemistry; D005998:Glycine; D007202:Indicators and Reagents; D008722:Methods; D011804:Quinolines; D013654:Taurine
chemical_list: D001647:Bile Acids and Salts; D007202:Indicators and Reagents; D011804:Quinolines; D013654:Taurine; C000470:EEDQ; D005998:Glycine