Enhancement of barium- and cesium-induced adrenal catecholamine release by lidocaine.
Catecholamine release evoked from isolated perfused bovine adrenals by Ba+2 or Cs+ is enhanced by lidocaine or by a calcium-free medium. The action of Cs+ therefore differs from that of K+ or Rb+ in adrenal medulla. Divalent and monovalent metallic cations of relatively large atomic weight like Ba+2 and Cs+, probably penetrate the cell more easily than small highly charged ions and act intracellularly to cause adrenal catecholamine release. Local anesthetics and calcium-free media may allow greater influx of Ba+2 and Cs+ into adrenomedullary cells.
D000311:Adrenal Glands / Q000187:drug effects / Q000378:metabolism*; D000818:Animals; D001464:Barium / Q000494:pharmacology*; D002395:Catecholamines / Q000378:metabolism*; D002417:Cattle; D002586:Cesium / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D066298:In Vitro Techniques; D008012:Lidocaine / Q000494:pharmacology*; D010477:Perfusion; D012413:Rubidium / Q000494:pharmacology
D002395:Catecholamines; D002586:Cesium; D001464:Barium; D008012:Lidocaine; D012413:Rubidium