[Plasma-digoxin concentration in patients at time of hospital admission (author's transl)].
Plasma-digoxin and serum creatinine concentrations were determined on admission in 145 unselected patients previously digitalized as outpatients. Adequate digitalization was found in 62.7%, inadequate doses in 15.9% of patients. In the latter group the daily dosage reported by the patients failed to correlate with the plasma-digoxin concentration by radioimmunoassay. One-fifth of all patients had clinical evidence of digitalis intoxication. Of these, 69% had plasma-digoxin concentrations of more than 2.0 ng/ml and 31% less than 2.0 ng/ml. Mean digoxin concentration for all patients with signs of digitalis intoxication was 2.5+/-0.9 ng/ml. In patients simultaneously receiving spironolactone or canrenoate-K+ there was danger of falsely high values for digoxin because of interference of those drugs with the radioimmunoassay.
D000553:Ambulatory Care; D002191:Canrenoic Acid / Q000494:pharmacology; D003404:Creatinine / Q000097:blood; D004071:Digitalis Glycosides / Q000627:therapeutic use; D004077:Digoxin / Q000097:blood* / Q000506:poisoning; D005260:Female; D006760:Hospitalization; D006801:Humans; D008297:Male; D011863:Radioimmunoassay; D013148:Spironolactone / Q000494:pharmacology
D004071:Digitalis Glycosides; D013148:Spironolactone; D004077:Digoxin; D002191:Canrenoic Acid; D003404:Creatinine
Aktuelle Plasma-Digoxinkonzentration von Patienten bei Krankenhausaufnahme.