title: The anemia of vitamin E deficiency in swine: an experimental model of the human congenital dyserythropoietic anemias.
abstract: The ultrastructural and erythrokinetic characteristics of vitamin E deficiency in swine were investigated in an effort to evaluate the suitability of the swine disorder as a model of the human congenital dyserythropoietic anemias. The dominant erythrokinetic abnormality in vitamin E deficient pigs, as in the CDAs, is ineffective erythropoiesis. As in some patients with CDA, the activity of a number of erythrocyte enzymes was increased. Distinctive ultrastructual changes previously described in patients with CDA were found in normoblasts from vitamin E deficient pigs. The morphologic, erythrokinetic, biochemical and ultrastructural similarities between vitamin E deficiency in swine and the CDAs in man appear to justify the study of the animal disorder as a model of the human disease. A complete hematologic response was elicited by the administration not only of vitamin E, but also, as in the previous studies of vitamin E deficiency in monkeys, by hexahydrocoenzyme Q4. The partial hematologic response occurring after deletion of tocopherol stripped corn oil from the diet indicates that factors other than the dietary lack of vitamin E are important in the pathogenesis of this disorder.
mesh_terms: D000740:Anemia / Q000151:congenital* / Q000209:etiology / Q000378:metabolism; D000818:Animals; D001853:Bone Marrow / Q000648:ultrastructure; D001854:Bone Marrow Cells; D004195:Disease Models, Animal; D007501:Iron / Q000378:metabolism; D013552:Swine; D014451:Ubiquinone / Q000378:metabolism; D014810:Vitamin E / Q000378:metabolism; D014811:Vitamin E Deficiency / Q000150:complications* / Q000378:metabolism / Q000473:pathology
chemical_list: D014451:Ubiquinone; D014810:Vitamin E; D007501:Iron