Mesenteric fibromatosis associated with familial polyposis.
This patient represents the 25th case report of mesenteric fibromatosis in patients with Gardner's syndrome. Her family genealogy reveals polyposis of the colon in nine members in four generations. In addition, one member has papillary carcinoma of the thyroid and one has newly discovered osteomas. To our knowledge, this family may be the first to manifest this combination of extracolonic lesions with familial polyposis, and the case supports a single-gene etiology for the complete syndrome.
D000328:Adult; D002291:Carcinoma, Papillary / Q000150:complications / Q000235:genetics; D003110:Colonic Neoplasms / Q000150:complications* / Q000235:genetics; D005260:Female; D005350:Fibroma / Q000150:complications*; D005796:Genes; D006801:Humans; D007417:Intestinal Polyps / Q000150:complications* / Q000235:genetics; D008643:Mesentery; D009378:Neoplasms, Multiple Primary / Q000150:complications; D009808:Odontogenic Tumors / Q000150:complications; D010016:Osteoma / Q000150:complications; D010375:Pedigree; D012878:Skin Neoplasms / Q000150:complications; D013577:Syndrome; D013964:Thyroid Neoplasms / Q000150:complications / Q000235:genetics