title: Effects of gestational age, birth weight, and hypoxemia on pharmacokinetics of amikacin in serum of infants.
abstract: The serum pharmacokinetics of amikacin were studied in 36 infants treated for suspected bacterial infection. A prolonged serum half-life was associated with the related variables of birth at an early gestational age, low birth weight, and hypoxemia. A postnatal age effect was not apparent when hypoxemic infants were excluded.
mesh_terms: D000583:Amikacin / Q000097:blood*; D001424:Bacterial Infections / Q000097:blood*; D001724:Birth Weight; D005260:Female; D005865:Gestational Age; D006801:Humans; D000860:Hypoxia / Q000097:blood*; D007231:Infant, Newborn; D007232:Infant, Newborn, Diseases / Q000097:blood*; D007612:Kanamycin / Q000031:analogs & derivatives*; D008297:Male
chemical_list: D007612:Kanamycin; D000583:Amikacin