Biochemical gradients in the human gastric and duodenal mucosa in relation to basal acid outputs.
The separations and measurements of adenine-adenosine, adenosine monophosphate (AMP), adenosine diphosphate (ADP), adenosine triphosphate (ATP), lipid phosphates (lipid-P), ribonucleic acid (RNA) and deoxyribonucleic acid (DNA) were carried out in the mucosa of the corpus, antrum, and duodenum of patients with decreased, normal, and increased basal acid outputs (BAO). The results were calculated in correspondence to 1.0 mg DNA value. The results indicate: 1) the biochemical composition of the corpus and antral mucosa alters with increase of BAO; 2) a significant difference was found between the biochemical compositions of the mucosa of the corpus and antrum in patients with normal and increased BAO; 3) no significant difference was observed in the biochemical components of duodenal mucosa with different BAO.
D000227:Adenine Nucleotides / Q000378:metabolism*; D000244:Adenosine Diphosphate / Q000378:metabolism; D000249:Adenosine Monophosphate / Q000378:metabolism; D000255:Adenosine Triphosphate / Q000378:metabolism; D004247:DNA / Q000378:metabolism*; D004386:Duodenum / Q000378:metabolism*; D005750:Gastric Juice / Q000378:metabolism*; D005753:Gastric Mucosa / Q000378:metabolism*; D006801:Humans; D007413:Intestinal Mucosa / Q000378:metabolism*; D010437:Peptic Ulcer / Q000378:metabolism*; D011706:Pyloric Antrum / Q000378:metabolism; D012313:RNA / Q000378:metabolism*
D000227:Adenine Nucleotides; D000249:Adenosine Monophosphate; D000244:Adenosine Diphosphate; D012313:RNA; D000255:Adenosine Triphosphate; D004247:DNA