Simplification of glutathione-bicarbonate-Ringer solution: its effect on corneal thickness.
Glutathione and adenosine can safely be omitted from glutathione-bicarbonate-Ringer solution (GBR) which is used as an irrigating solution during vitrectomy, without significant reduction in the solution's efficacy or increase in corneal toxicity. Bicarbonate appears to be an essential ingredient and should not be omitted from the Ringer solution.
D000241:Adenosine / Q000494:pharmacology; D000818:Animals; D001639:Bicarbonates / Q000494:pharmacology*; D003315:Cornea / Q000187:drug effects* / Q000473:pathology; D004727:Endothelium / Q000187:drug effects / Q000473:pathology; D005978:Glutathione / Q000494:pharmacology*; D007552:Isotonic Solutions / Q000494:pharmacology*; D011817:Rabbits; D007507:Therapeutic Irrigation
D001639:Bicarbonates; D007552:Isotonic Solutions; D005978:Glutathione; D000241:Adenosine