Spontaneous fibrosarcoma in a thymus-transplanted nude mouse.
A fibrosarcoma was observed in a 6-month-old nude mouse that had a neonatal thymus transplant and had been kept since birth under nearly pathogen-free conditions. This was the first tumor found in more than 1,000 nude mice maintained in a colony in which mammary carcinomas were observed among the female heterozygous breeders. This finding confirmed the fact that malignant neoplasms are rare in an animal model that lacks T-cell-mediated immunologic capability and apparently contradicted the postulates of the immunosurveillance theory.
D000008:Abdominal Neoplasms / Q000276:immunology / Q000473:pathology; D000818:Animals; D000831:Animals, Newborn; D005260:Female; D005354:Fibrosarcoma / Q000276:immunology* / Q000473:pathology; D008297:Male; D051379:Mice; D008819:Mice, Nude; D013950:Thymus Gland / Q000637:transplantation*; D014184:Transplantation, Homologous