Reactive hyperaemia in the dog heart: inter-relations between adenosine, ATP, and aminophylline and the effect of indomethacin.
Intracoronary adenosine, ATP, and the release of an 8 second occlusion increased coronary blood flow (CBF) to a similar extent. Aminophylline decreased the CBF response to adenosine by 80% and that to an 8 s occlusion by 20% but did not change the CBF response to ATP. Indomethacin had no effect on CBF. The results suggest that the increase in CBF after brief occlusions is not mediated in a major way by adenosine or prostaglandins.
D000241:Adenosine / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D000255:Adenosine Triphosphate / Q000494:pharmacology*; D000628:Aminophylline / Q000494:pharmacology*; D000818:Animals; D003326:Coronary Circulation / Q000187:drug effects*; D004285:Dogs; D006940:Hyperemia / Q000378:metabolism*; D007213:Indomethacin / Q000494:pharmacology; D014666:Vasomotor System / Q000187:drug effects
D000628:Aminophylline; D000255:Adenosine Triphosphate; D000241:Adenosine; D007213:Indomethacin