Quantitative determinations of codeine phosphate, guaifenesin, pheniramine maleate, phenylpropanolamine hydrochloride, and pyrilamine maleate in an expectorant by high-pressure liquid chromatography.
The quantitative determinations of codeine phosphate, guaifenesin, pheniramine maleate, phenylpropanolamine hydrochloride, and pyrilamine maleate in a liquid dosage form are described. All active and inactive ingredients (sodium benzoate and FD&C Yellow No. 5 dye) can be separated with high-pressure liquid chromatography except the two antihistamines, pheniramine maleate and pyrilamine maleate. Pheniramine maleate is determined colorimetrically, and pyrilamine maleate is determined either by difference or spectrophotometrically. The methods are simple short, accurate, and precise. The standard deviations are reported.
D002851:Chromatography, High Pressure Liquid; D003061:Codeine / Q000032:analysis*; D003124:Colorimetry; D004338:Drug Combinations; D005100:Expectorants / Q000032:analysis; D006140:Guaifenesin / Q000032:analysis*; D008722:Methods; D010632:Pheniramine / Q000032:analysis*; D010665:Phenylpropanolamine / Q000032:analysis*; D011725:Pyridines / Q000032:analysis*; D011738:Pyrilamine / Q000032:analysis*; D012996:Solutions / Q000032:analysis; D013056:Spectrophotometry, Ultraviolet
D004338:Drug Combinations; D005100:Expectorants; D011725:Pyridines; D012996:Solutions; D010632:Pheniramine; D010665:Phenylpropanolamine; D006140:Guaifenesin; D011738:Pyrilamine; D003061:Codeine