Synthesis of some 3.4.5-trimethoxybenzyl derivatives of certain amino compounds likely to posses cns activity.
The condensation of 3.4.5-trimethoxybenzyl chloride with certain amines is described. Reacting the aralkyl chloride with 4-aminophenazone, 2-aminopyridine, piperidine, N-methylpiperazine, pyrrolidine and morpholine yielded the corresponding trimethoxybenzyl derivatives la--f. On the other hand, alpha-[3.4.5-trimethoxybenzamido]-glutarimide (2) was synthesized via the acylation of glutamic acid with trimethoxybenzoyl chloride, dehydration of the N-acyl derivative and finally imidation of the inner anhydride thus formed.
D000632:Aminopyrine; D000840:Anisoles / Q000138:chemical synthesis*; D002490:Central Nervous System / Q000187:drug effects; D009025:Morpholines; D010879:Piperazines; D010880:Piperidines; D011759:Pyrrolidines
D000840:Anisoles; D009025:Morpholines; D010879:Piperazines; D010880:Piperidines; D011759:Pyrrolidines; D000632:Aminopyrine