Hepatic sensitivity to imipramine.
A case of significant hepatic reaction related to imipramine is presented, documented by challenge with imipramine and liver biopsy. The mechanism, while not entirely clear, is presumed to involve hypersensitivity or induction of toxic metabolites.
D000328:Adult; D001707:Biopsy, Needle; D056486:Chemical and Drug Induced Liver Injury / Q000209:etiology* / Q000473:pathology; D005260:Female; D006801:Humans; D007099:Imipramine / Q000009:adverse effects*; D008099:Liver / Q000187:drug effects* / Q000473:pathology
D007099:Imipramine