Direct effect of acebutolol on force generation in immature and adult myocardium.
The effect of acebutolol on active isometric force generation has been studied in isolated papillary muscle preparations from adult cats and kittens less than 24 h old. Statistically significant reduction in active force occurred at a concentration of 0.27 mmol-litre-1 in the adult preparations and at 1.34 mmol-litre-1 in the infant ones. At 2.86 mmol-litre-1 active force had fallen to 43.4%+/-2.2 (SEM) of the control value in the adults and to 52.4%+/-3.3(SEM) in the infants. These results suggest that the infant myocardium is no more sensitive to the negative inotropic effect of acebutolol than is the adult myocardium.
D000070:Acebutolol / Q000494:pharmacology*; D000367:Age Factors; D000818:Animals; D000831:Animals, Newborn; D002415:Cats; D003864:Depression, Chemical; D004305:Dose-Response Relationship, Drug; D006321:Heart / Q000254:growth & development; D066298:In Vitro Techniques; D009200:Myocardial Contraction / Q000187:drug effects*; D010210:Papillary Muscles / Q000187:drug effects
D000070:Acebutolol