title: 3-Amino-1-(3,4-dichloro-alpha-methyl-benzyl)-2-pyrazolin-5-one (Bay g 2821), a potent diuretic from a new substance class.
abstract: Chemistry, salidiuretic activity and mechanism of action of 3-amino-1-(3,4-dichloro-alpha-methyl-benzyl)-2-pyrazolin-5-one (Bay g 2821), a new diuretic, are described. Owing to the initial rapid onset of activity, the reserve in capacity and the additional long duration of activity, this substance represents a potent diuretic and antihypertensive agent.
mesh_terms: D000818:Animals; D001639:Bicarbonates / Q000652:urine; D002712:Chlorides / Q000652:urine; D004231:Diuresis / Q000187:drug effects; D004232:Diuretics / Q000138:chemical synthesis / Q000494:pharmacology; D004285:Dogs; D004305:Dose-Response Relationship, Drug; D007700:Kinetics; D008970:Molecular Weight; D011188:Potassium / Q000652:urine; D011720:Pyrazoles / Q000494:pharmacology*; D012964:Sodium / Q000652:urine; D013997:Time Factors
chemical_list: D001639:Bicarbonates; D002712:Chlorides; D004232:Diuretics; D011720:Pyrazoles; D012964:Sodium; D011188:Potassium