Effects of subcutaneously implanted sustained-release cyclophosphamide capsules on Walker 256 solid rat tumor.
Complete regression of Walker 256 solid rat tumor was brought about by the subcutaneous implantation of a single sustained-release cyclophosphamide capsule adjacent to the tumor mass. Untreated control animals died within 3 weeks after receiving the tumor with large necrotic masses. Rats with sustained-release capsules experienced complete tumor regression within 28 days. Upon examination, the tissues around the previous tumor mass has regenerated, and no viable tumor cells could be found in the area where the previous tumor mass was. Around the implanted sustained-release cyclophosphamide capsule a fibrous sheath has developed over the 3 weeks it was in situ. This study suggests an alternate means of cytoxic drug administration in the treatment of solid tumors in experimental animals.
D000818:Animals; D002214:Capsules; D002279:Carcinoma 256, Walker / Q000188:drug therapy*; D003520:Cyclophosphamide / Q000008:administration & dosage* / Q000627:therapeutic use; D003692:Delayed-Action Preparations; D004343:Drug Implants; D051381:Rats; D012075:Remission, Spontaneous
D002214:Capsules; D003692:Delayed-Action Preparations; D004343:Drug Implants; D003520:Cyclophosphamide