Synthesis of some quinoline derivatives of potential antiamebic activity.
New compounds derived from cinchoninic acid esters and amides were prepared. The esters are those derived from p-hydroxy-N-methyldichloroacetanilide (diloxanide) whereas the amides are from piperazine whose hydrogen is substituted by a dichloroacetyl group. The dichloroacetamido group is responsible for the amebicidal activity in several related compounds.
D000563:Amebicides / Q000138:chemical synthesis; D011804:Quinolines / Q000138:chemical synthesis* / Q000494:pharmacology
D000563:Amebicides; D011804:Quinolines