Effect of kininogen on the activity of the kallikreinogen-kallikrein system of human blood serum.
In experiments with kallikreinogen, kallikrein and kininogen preparations from human blood serum partially purified on QAE-Sephadex A-50, CM-Sephadex and Sephadex G-200 it was established that N-benzoyl-L-arginine ethyl ester (BAEE)-esterase activity of kallikrein and the process of autoactivation of kallikreinogen are inhibited by kininogen, especially by its high-molecular form.
D001120:Arginine / Q000031:analogs & derivatives; D003864:Depression, Chemical; D004789:Enzyme Activation / Q000187:drug effects; D006801:Humans; D066298:In Vitro Techniques; D007610:Kallikreins / Q000378:metabolism / Q000502:physiology*; D007704:Kininogens / Q000302:isolation & purification / Q000494:pharmacology*; D008970:Molecular Weight; D011288:Prekallikrein / Q000302:isolation & purification / Q000502:physiology*; D013997:Time Factors; D014357:Trypsin / Q000494:pharmacology
D007704:Kininogens; D011288:Prekallikrein; D001120:Arginine; D007610:Kallikreins; D014357:Trypsin