title: Fatty acid and glucose metabolism in selenium deficient rats and lambs.
abstract: Fatty acid analyses were done on tissues of lambs from ewes fed purified diets, and injected with selenium and/or vitamin E in a 2 X 2 factorial treatment. The concentrations of arachidonic acid averaged 9.3% of the total fatty acid content in semitendinosus muscle from lambs given vitamin E and selenium, but averaged 19.4% in this muscle from lambs given vitamin E without selenium. Arachidonic acid comprised 28.3% and 33.7%, respectively, of the total fatty acids in livers from selenium supplemented and deficient rats. Twice as much radioactivity from [1-(14)C]acetate was recovered in rat liver phospholipid arachidonate in selenium deficient rats as in selenium supplemented ones, indicating a greater turnover rate of this fatty acid in deficient rats. Fifty-five percent of dosed 14C-glucose (either [1-(14)C] or [6-(14)C]glucose) was recovered within 3 hours as 14CO2 from selenium deficient rats. This recovery dropped to one-half this value when these rats were fed a diet containing 0.1 ppm selenium for only 7 days. This increased glucose metabolism is suggestive of a greater metabolic rate in selenium deficient animals, which may be responsible for the differences observed in tissue fatty acid composition.
mesh_terms: D000818:Animals; D001095:Arachidonic Acids / Q000378:metabolism; D002245:Carbon Dioxide; D005227:Fatty Acids / Q000378:metabolism*; D005260:Female; D005947:Glucose / Q000378:metabolism*; D008099:Liver / Q000378:metabolism; D008297:Male; D009132:Muscles / Q000378:metabolism; D010743:Phospholipids / Q000378:metabolism; D051381:Rats; D012643:Selenium / Q000172:deficiency* / Q000627:therapeutic use; D012756:Sheep / Q000378:metabolism*; D013045:Species Specificity; D014810:Vitamin E / Q000494:pharmacology*
chemical_list: D001095:Arachidonic Acids; D005227:Fatty Acids; D010743:Phospholipids; D014810:Vitamin E; D002245:Carbon Dioxide; D012643:Selenium; D005947:Glucose