Participation of prostaglandins in pathogenesis of aspirin-sensitive asthma.
Recent evidence suggests that the induction of bronchoconstriction in aspirin-sensitive patients by analgesics is due to the inhibition of PG biosynthesis in their respiratory tract. PGEs might play the main defensive role in the bronchi of aspirin-sensitive asthmatics. Removal of this potent bronchodilator by PG synthetase inhibitors leaves the effects of spasmogens unopposed, and possibly promotes the release of histamine from its stores.
D001241:Aspirin / Q000009:adverse effects*; D001249:Asthma / Q000139:chemically induced / Q000378:metabolism*; D004342:Drug Hypersensitivity / Q000378:metabolism*; D006801:Humans; D011453:Prostaglandins / Q000378:metabolism*
D011453:Prostaglandins; D001241:Aspirin