Effect of intestinal microflora suppression on liver carcinogenicity of dimethylnitrosamine in Syrian hamsters.
Liver tumors induced by dimethylnitrosamine showed an increased incidence in Syrian hamsters with intestinal microflora suppressed by antibiotics, as compared with the incidence in animals not treated with antibiotics. The possible mechanisms, including metabolic alterations caused by changes in the normal microflora population, were discussed.
D000818:Animals; D000900:Anti-Bacterial Agents / Q000494:pharmacology; D006224:Cricetinae; D004128:Dimethylnitrosamine; D005260:Female; D005856:Germ-Free Life; D007422:Intestines / Q000187:drug effects / Q000382:microbiology*; D008113:Liver Neoplasms / Q000139:chemically induced / Q000209:etiology*; D008297:Male; D008647:Mesocricetus; D009374:Neoplasms, Experimental / Q000139:chemically induced / Q000209:etiology; D009602:Nitrosamines
D000900:Anti-Bacterial Agents; D009602:Nitrosamines; D004128:Dimethylnitrosamine