Radiation necrosis of the scalp: a complication of cranial irradiation and methotrexate.
A case of childhood leukemia with a severe skin reaction following a course of medium-dose cranial irradiation and intrathecal methotrexate is presented. Necrosis of the scalp of partial to full thickness resulted. The authors believe potentiation of the radiation reaction by methotrexate was the probable cause.
D002675:Child, Preschool; D006801:Humans; D007938:Leukemia / Q000188:drug therapy / Q000532:radiotherapy; D008297:Male; D008727:Methotrexate / Q000009:adverse effects* / Q000627:therapeutic use; D009336:Necrosis / Q000139:chemically induced / Q000209:etiology; D011832:Radiation Injuries; D011878:Radiotherapy / Q000009:adverse effects*; D012536:Scalp Dermatoses / Q000139:chemically induced / Q000209:etiology*
D008727:Methotrexate