title: The insensitivity of Vinca rosea to vinblastine.
abstract: Root tip mitosis in both Vinca rosea and the chosen control Lepidium sativum is susceptible to the effects of colchicine at and above 5X10(-4)M.--Root tip mitosis in L. sativum is susceptible to the effects of vinblastine at concentrations equal to and greater than 10(-4)M, while root tip mitosis in V. rosea, the plant which is the source of vinblastine, is unaffected by exogenously-applied VBL at concentrations up to and including 10(-2)M.--The possible mechanisms by which the resistance of V. rosea to vinblastine might be conferred are discussed.
mesh_terms: D008938:Mitosis / Q000187:drug effects; D059828:Plant Cells; D010944:Plants / Q000187:drug effects*; D014747:Vinblastine / Q000494:pharmacology*
chemical_list: D014747:Vinblastine