The influence of lysosomes on glycogen metabolism.
Lysosome-rich fractions were isolated from rat liver homogenates. In some fractions the lysosomes were separated from the contaminating mitchondria by the use of discontinuous Ficoll/sucrose gradients. Some glycogen was associated with lysosome fractions. This glycogen was of very large molecular size and of a quite different molecular-weight distribution from that isolated from the cytosol. It is suggested that appreciably more than 10% of cellular glycogen is located within the lysosome.
D000818:Animals; D002458:Cell Fractionation; D066298:In Vitro Techniques; D008099:Liver / Q000378:metabolism; D008112:Liver Glycogen / Q000378:metabolism*; D008247:Lysosomes / Q000201:enzymology / Q000378:metabolism*; D008297:Male; D008970:Molecular Weight; D051381:Rats
D008112:Liver Glycogen