[The liver and drugs. Blood chemical and ultrastructural findings after experimental administration of 7-cromanol-3-methyl-taxifoline].
An experimental model which, unlike classical animal pharmacology models, stresses behaviour not of the organ or organism as a whole but of the cell ultrastructures of linked metabolic areas, is proposed. The new model would appear capable, within limits, of surmounting some of the main objections made when extrapolating animal data and referring it to humans. The application of the model to the analysis of the effects induced by administration of 7C3MT at the level of the liver cell metabolic areas described. Electron microscope observations show the substance has a positive influence on the functioning of structures engaged in synthesis and those occupied in breaking down drugs, thus supporting the hypothesis that the substance improves the liver's functional kinetics.
D000818:Animals; D001711:Biotransformation / Q000187:drug effects*; D001786:Blood Glucose / Q000032:analysis; D002802:Cholinesterases / Q000378:metabolism; D005419:Flavonoids / Q000494:pharmacology*; D050356:Lipid Metabolism; D008099:Liver / Q000187:drug effects* / Q000378:metabolism / Q000648:ultrastructure; D008115:Liver Regeneration / Q000187:drug effects; D009584:Nitrogen / Q000097:blood; D011506:Proteins / Q000378:metabolism; D011794:Quercetin / Q000031:analogs & derivatives / Q000494:pharmacology*; D011817:Rabbits; D000637:Transaminases / Q000378:metabolism
D001786:Blood Glucose; D005419:Flavonoids; D011506:Proteins; D011794:Quercetin; D000637:Transaminases; D002802:Cholinesterases; D009584:Nitrogen
Fegato e farmaci. Rilievi ematochimici ed ultrastrutturali dopo somministrazione sperimentale di 7-cromanol-3-metil-taxifolina