Serum lysozyme levels in inflammatory bowel disease.
Serum lysozyme levels were compared in patients with Crohn's disease (CD) and chronic ulcerative colitis (CUC) to determine if the two diseases could be differentiated by this parameter. The lysozyme concentrations were measured by three different methods: 1. the turbidimetric clearance of Micrococcus lysodeikticus utilizing egg white lysozyme as a standard; 2. the lysoplate assay of Osserman and Lawlor using a human lysozyme standard obtained from Dr. Osserman and 3. the lysoplate assay obtained as a commercial kit using human lysozyme as a standard. A series of 19 CD and 23 CUC patients were compared. Contrary to the report of Falchuk, et al, the serum lysozyme levels by any of the three methods were not statistically significantly different in the two diseases. The serum levels of those with severe, moderate, or inactive disease were also not significant for CD or CUC nor in serially followed patients did levels always correspont to changes in clinical course.
D000293:Adolescent; D000328:Adult; D000368:Aged; D001681:Biological Assay; D002908:Chronic Disease; D003093:Colitis, Ulcerative / Q000201:enzymology*; D003424:Crohn Disease / Q000201:enzymology*; D005260:Female; D006801:Humans; D008297:Male; D008722:Methods; D008837:Micrococcus / Q000187:drug effects; D008875:Middle Aged; D009113:Muramidase / Q000097:blood*; D009391:Nephelometry and Turbidimetry
D009113:Muramidase