Use of an in vivo oxygen electrode to determine the effect of hemorrhagic shock on liver oxygen tension.
Measurement of arterial and liver tissue oxygen tension (PO2) in animals subjected to hemorrhagic shock demonstrates a significant (p less than 0.001) decrease in tissue PO2 while PaO2 remains essentially unchanged. In fact, marked increase in PaO2 fail to increase tissue PO2 to control levels, demonstrating that the act of increasing FIO2 and/or PaO2 is inadequate treatment of decreased tissue oxygenation in marginal or low flow states. Measurement of tissue PO2 in a variety of clinical situations seems warranted to allow alterations of therapy to improve flow when indicated by inadequate tissue oxygenation. The application of this simple but extremely useful technic should result in improved survival rates in critically ill patients.
D000818:Animals; D002404:Catheterization; D004285:Dogs; D004566:Electrodes; D008099:Liver / Q000378:metabolism*; D010100:Oxygen / Q000097:blood / Q000378:metabolism*; D012771:Shock, Hemorrhagic / Q000097:blood / Q000378:metabolism*
D010100:Oxygen