The effect of hyperthermia on aqueous humor dynamics in rabbits.
Hyperthermia increased intraocular pressure (Po) by approximately 5 mm Hg in rabbit eyes. This increase was not associated with changes in plasma osmolarity, blood lactate, or pH. Episcleral venous pressure (Pv) decreased from a baseline of 11 +/- 1 mm Hg(mean +/- SEM) to 8 +/- 1 mm Hg after one hour of hyperthermia. Outflow facility (c) as measured by tonography remained unchanged. Aqueous humor flow [c(Po - Pv)] as estimated by tonography increased by about 126%. The elevation of intraocular pressure was not prevented by aspirin pretreatment nor altered by unilateral optic nerve transection.
D000818:Animals; D001082:Aqueous Humor / Q000187:drug effects / Q000502:physiology*; D001241:Aspirin / Q000494:pharmacology; D001794:Blood Pressure; D005334:Fever / Q000209:etiology / Q000503:physiopathology* / Q000517:prevention & control; D007429:Intraocular Pressure / Q000187:drug effects; D008297:Male; D009900:Optic Nerve / Q000601:surgery; D011817:Rabbits; D014690:Venous Pressure
D001241:Aspirin