Small airway constriction and closure after induced intravascular platelet aggregation.
The aim of this study was to investigate the function of the peripheral airways after intravascular platelet aggregation induced by i.v. infusions of collagen in open chest anesthetized cats, ventilated with constant tidal volume. Lung compliance was examined under static conditions (stat CL) and under dynamic conditions (dyn CL) at ventilation frequencies of 5, 24 and 50/min. In the control situation dyn CL 24 was approximately 90% of stat CL. Collagen infusions resulted in a pronounced frequency-dependence of lung compliance. When dyn CL 24 had decreased by approximately 40% a reduction in stat CL could also be detected. When dyn CL 24 decreased even more a concurrent reduction in stat CL was evident. These findings indicate that the initial event after induced intravascular platelet aggregation is small airway constriction. With more pronounced changes airway closure and reduction in lung volume occurs. We suggest that these functional changes in peripheral airways result in the impaired gas exchange known to occur after intra-vascular platelet aggregation.
D000818:Animals; D002415:Cats; D003094:Collagen / Q000008:administration & dosage / Q000494:pharmacology; D007263:Infusions, Parenteral; D008170:Lung Compliance; D010974:Platelet Aggregation / Q000187:drug effects; D011655:Pulmonary Embolism / Q000139:chemically induced / Q000503:physiopathology*; D012119:Respiration / Q000187:drug effects; D013990:Tidal Volume; D013997:Time Factors
D003094:Collagen