Sequence analysis of porcine gut GLI-1.
A protein from porcine gut with 100 amino acid residues (porcine gut GLI-1) and having glucagon-like immunoreactivity has been characterized by partial sequences. The sequence of the C-terminal amino acid residues is -Met-Asn-Thr-Lys-Arg-Asn-Lys-Asn-Asn-Ile-Ala and includes the C-terminal amino acid residue sequence (-Met-Asn-Thr) of porcine glucagon. Evidence is presented that the glucagon sequence -Thr-Ser-Asp-Tyr-Ser-Lys-Tyr- is found in the gut GLI-1 as well. The data support the theory that gut GLI-1 contains the full glucagon sequence and that gut GLI-1 and glucagon are formed from a common precursor.
D000595:Amino Acid Sequence; D000596:Amino Acids / Q000032:analysis; D000818:Animals; D005768:Gastrointestinal Hormones / Q000276:immunology / Q000302:isolation & purification; D005934:Glucagon / Q000276:immunology; D007422:Intestines; D010446:Peptide Fragments / Q000032:analysis; D010447:Peptide Hydrolases; D010455:Peptides / Q000276:immunology / Q000302:isolation & purification; D011498:Protein Precursors; D013552:Swine
D000596:Amino Acids; D005768:Gastrointestinal Hormones; D010446:Peptide Fragments; D010455:Peptides; D011498:Protein Precursors; D005934:Glucagon; D010447:Peptide Hydrolases