Delayed appearance of propranolol sensitivity in cultured heart cells.
Examination of the appearance of adrenaline responsiveness and propranolol sensitivity with culture age in myoblasts cultured from neonatal rat hearts shows that propranolol sensitivity lags behind adrenergic responsiveness. Such a finding may illustrate subtle differences in sites for agonist and antagonist at the beta-receptor of these cells.
D000818:Animals; D000831:Animals, Newborn; D002478:Cells, Cultured; D004837:Epinephrine / Q000494:pharmacology; D006339:Heart Rate / Q000187:drug effects*; D011217:Practolol / Q000494:pharmacology; D011433:Propranolol / Q000494:pharmacology*; D051381:Rats; D013997:Time Factors
D011433:Propranolol; D011217:Practolol; D004837:Epinephrine