title: Proliferation characteristics of erythroblasts in chronic renal failure.
abstract: Proliferation of bone marrow erythroblasts in patients with chronic renal disease was studied by combined application of cytophotometric measurement of the DNA content and 3H-TdR labeling in vitro. A striking decrease of 3H-TdR labeling was found in most of the cases. The proportion of diploid (G0 + G1) as well as of tetraploid unlabeled cells (G2) was increased. The data suggest a disturbed induction of DNA synthesis of resting cells as well as an arrest of cells in G2 being responsable for ineffective cell production in this disease.
mesh_terms: D000328:Adult; D000368:Aged; D001345:Autoradiography; D001853:Bone Marrow; D001854:Bone Marrow Cells; D002455:Cell Division; D004171:Diploidy; D004900:Erythroblasts; D004912:Erythrocytes; D005260:Female; D006801:Humans; D007676:Kidney Failure, Chronic / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D010783:Photometry; D011123:Polyploidy