Human chorionic gonadotropin produced by ectopic pinealoma in a girl with precocious puberty. Case report.
A case is reported in which a human chorionic gonadotropin (HCG-)-producing ectopic pinealoma was found in a 5-year-old girl with precocious puberty. Physical examination revealed abnormal breast enlargement. Endocrinological study disclosed a high plasma HCG concentration of 1192 ng/ml with a normal follicular stimulating hormone (FSH) level. The HCG content of the tumor was as high as 400 ng/mg of acetone dried tissue, but no FSH was detectable. This is the first reported case of precocious puberty associated with pineal tumor in a female.
D002551:Cerebral Ventricle Neoplasms / Q000378:metabolism* / Q000648:ultrastructure; D002675:Child, Preschool; D006063:Chorionic Gonadotropin / Q000096:biosynthesis*; D005260:Female; D005640:Follicle Stimulating Hormone / Q000378:metabolism; D006729:Hormones, Ectopic / Q000096:biosynthesis*; D006801:Humans; D007986:Luteinizing Hormone / Q000378:metabolism; D010871:Pinealoma / Q000378:metabolism* / Q000648:ultrastructure; D011388:Prolactin / Q000378:metabolism; D011629:Puberty, Precocious / Q000209:etiology*
D006063:Chorionic Gonadotropin; D006729:Hormones, Ectopic; D011388:Prolactin; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone