title: Synthesis and properties of new cyclic derivatives of succinic acid with anticonvulsant activity.
abstract: The synthesis and pharmacological screening of a series of new phenylsuccinimide derivatives are described. Seven compounds of that series elicited a marked anticonvulsant activity. Among the compounds tested, interesting structures were those metasubstituted with bromine, fluorine or trifluoromethyl group. The most interesting drug seems to be the N-morpholinemethyl derivative of mbromophenylsuccinimide, which has a long duration of activity, elicits a very strong antipentetrazole action, and gives good protection against maximal electroshock seizures.
mesh_terms: D000927:Anticonvulsants / Q000138:chemical synthesis* / Q000633:toxicity; D055598:Chemical Phenomena; D002621:Chemistry; D007928:Lethal Dose 50; D013388:Succinimides / Q000138:chemical synthesis* / Q000633:toxicity
chemical_list: D000927:Anticonvulsants; D013388:Succinimides