Reduction of gallstone formation by ascorbic acid in hamsters.
The addition of 0.5% of ascorbic acid to the lithogenic diet of golden hamsters whose body pool was labelled with 26-14C-cholesterol, lowered the formation of gallstones, the cholesterol concentration and half-life in blood plasma and in the liver, and accelerated cholesterol transformation to bile acids.
D000818:Animals; D001205:Ascorbic Acid / Q000627:therapeutic use*; D001206:Ascorbic Acid Deficiency / Q000150:complications; D001647:Bile Acids and Salts / Q000096:biosynthesis; D002769:Cholelithiasis / Q000209:etiology / Q000517:prevention & control*; D002784:Cholesterol / Q000097:blood / Q000378:metabolism; D006224:Cricetinae; D008099:Liver / Q000378:metabolism; D008297:Male; D008647:Mesocricetus
D001647:Bile Acids and Salts; D002784:Cholesterol; D001205:Ascorbic Acid