Pharmacokinetics of heparin after a single intravenous or subcutaneous injection.
In 2 groups of 4 probands the pharmacokinetics of heparin were investigated by a physiologic method (factor Xa inhibition) and an isotope method (35S-heparin) following a single intravenous injection of 5000 IU heparin and a single subcutaneous injection of 10000 IU heparin respectively. Following intravenous administration the anticoagulant effect and radioactivity fall exponentially. The half-life is about 50 min and the distribution volume 3000 ml (factor Xa inhibition) and 3800 ml (radioactivity). With subcutaneous injection peak concentrations above 0.2 IR heparin/ml were measured by both methods 2-4 h after administration; 9 h after administration, no further factor Xa inhibition was detectable in 2 probands. In the light of these and previously published results, some practical aspects of the conduct of therapy and prophylaxis of thromboembolism with heparin are discussed.
D000990:Antithrombin III / Q000378:metabolism; D006207:Half-Life; D006493:Heparin / Q000008:administration & dosage / Q000097:blood; D006801:Humans; D007275:Injections, Intravenous; D007279:Injections, Subcutaneous; D007700:Kinetics; D013460:Sulfur Isotopes
D013460:Sulfur Isotopes; D000990:Antithrombin III; D006493:Heparin
Pharmakokinetik von Heparin nach einmaliger intravenöser oder subkutaner Injektion.