[Study of the pharmacokinetics of dicloxacillin used parenterally in an experiment].
Dicloxacillin was superior to oxacillin in the maximum levels and retention time in the blood of dogs and rats. Dicloxacillin was intensively excreted by the kidneys for 3 hours. For 24 hours 62 per cent of the drug was excreted with the urine. In intravenous administration to animals the peaks of the antibiotics levels in the blood and internal organs were achieved at earlier periods, while the circulation time was shorter than in intramuscular administration. The intramuscular use of the drugs had no advantages in the kinetics against the oral use.
D000818:Animals; D001702:Biopharmaceutics; D004009:Dicloxacillin / Q000008:administration & dosage / Q000494:pharmacology*; D004285:Dogs; D004305:Dose-Response Relationship, Drug; D005260:Female; D007273:Injections, Intramuscular; D007275:Injections, Intravenous; D007700:Kinetics; D010068:Oxacillin / Q000494:pharmacology; D051381:Rats; D013997:Time Factors
D004009:Dicloxacillin; D010068:Oxacillin
Izuchenie farmakokinetiki dikloksatsillina pri parenteral'nom ego primenenii v éksperimente