[Mechanism of inhibition of rat liver microsomal monooxygenases during the development of cholestasis].
Alterations in the activity of rat liver monoxygenases were studied in dynamics of cholestasis development after ligation of biliary duct and the effects observed were compared to the latter after addition of cholesterol hydroxylated derivatives in vitro. Sodium deoxycholate at concentration 0.06-0.07% was shown to stimulate the alterations in the microsomal monooxygenases activity within fourth day and at concentration 0.09-0.12%--within seventh day of cholestasis.
D000632:Aminopyrine / Q000378:metabolism; D000814:Aniline Compounds / Q000378:metabolism; D000818:Animals; D002779:Cholestasis / Q000201:enzymology* / Q000378:metabolism; D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism; D003579:Cytochrome Reductases / Q000378:metabolism; D003580:Cytochromes / Q000378:metabolism*; D003840:Deoxycholic Acid; D004789:Enzyme Activation; D006591:Hexobarbital / Q000378:metabolism; D008297:Male; D008862:Microsomes, Liver / Q000201:enzymology* / Q000378:metabolism; D051381:Rats
D000814:Aniline Compounds; D003580:Cytochromes; D003840:Deoxycholic Acid; D000632:Aminopyrine; D003577:Cytochrome P-450 Enzyme System; D006591:Hexobarbital; D003579:Cytochrome Reductases
Mekhanizm ingibirovaniia mikrosomnykh monooksigenaz pecheni krys v protsesse razvitiia kholestaza.