title: Fat embolism prophylaxis: a study of four treatment modalities.
abstract: Significant coagulation and blood gas changes may occur with uncomplicated extremity fractures. To more accurately define the effect of therapy on these changes, a prospective study of 58 patients with uncomplicated fractures was undertaken. An initial group of 10 selected patients was studied to determine the changes with "standard therapy." The remaining 48 patients were then randomized into five groups: control, increased fluid intake, increased glucose intake, aspirin, and massive steroids. The patients were studied on 5 consecutive days. Treatment of patients in the latter four groups with aspirin or steroids resulted in significant normalization of blood gases, coagulation proteins, and platelet numbers when compared to controls. These measurements in patients treated with fluid loading or increased glucose intake were not significantly different from controls.
mesh_terms: D000293:Adolescent; D000328:Adult; D001241:Aspirin / Q000627:therapeutic use; D001792:Blood Platelets / Q000378:metabolism; D002245:Carbon Dioxide / Q000097:blood; D003911:Dextrans / Q000627:therapeutic use; D004620:Embolism, Fat / Q000209:etiology / Q000517:prevention & control* / Q000628:therapy; D005165:Factor V / Q000378:metabolism; D005340:Fibrinogen / Q000378:metabolism; D050723:Fractures, Bone / Q000150:complications*; D005950:Glucose Solution, Hypertonic / Q000627:therapeutic use; D006801:Humans; D007263:Infusions, Parenteral; D008775:Methylprednisolone / Q000627:therapeutic use; D008875:Middle Aged; D010100:Oxygen / Q000097:blood
chemical_list: D003911:Dextrans; D005950:Glucose Solution, Hypertonic; D002245:Carbon Dioxide; D005165:Factor V; D005340:Fibrinogen; D001241:Aspirin; D010100:Oxygen; D008775:Methylprednisolone