title: Toxic interactions of stimulants, narcotics and narcotic antagonists.
abstract: This study examines the lethality of combinations of central nervous system stimulants, narcotics and narcotic antagonists in rodents housed individually. The lethality of mice and rats from d-amphetamine was potentiated by methadone, cyclazocine and morphine, in that order of potency. Naloxone did not enhance lethality from d-amphetamine in mice, whereas it did antagonize lethality from morphine-d-amphetamine interactions. Naloxone did slightly enhance lethality from d-amphetamine in rats, but at a higher dose than those found to antagonize the lethality from morphine-d-amphetamine combinations. Methadone also enhanced the lethality from cocaine. These results have important implications for drug abusers and for patients being treated for narcotic addiction with either a methadone maintenance program or a cyclazocine administration program.
mesh_terms: D000818:Animals; D003042:Cocaine / Q000633:toxicity; D003496:Cyclazocine / Q000633:toxicity; D003913:Dextroamphetamine / Q000633:toxicity*; D004357:Drug Synergism; D008297:Male; D008691:Methadone / Q000633:toxicity; D051379:Mice; D009020:Morphine / Q000633:toxicity; D009270:Naloxone / Q000633:toxicity; D009292:Narcotic Antagonists / Q000633:toxicity*; D009294:Narcotics / Q000633:toxicity*; D051381:Rats
chemical_list: D009292:Narcotic Antagonists; D009294:Narcotics; D009270:Naloxone; D009020:Morphine; D003042:Cocaine; D003496:Cyclazocine; D003913:Dextroamphetamine; D008691:Methadone