Morphological changes of labyrinthine blood vessels following metal poisoning.
Metal intoxication (mercury and arsenic) in guinea pigs may cause damage to labyrinthine blood vessels by swelling of the endothelial cells, mitochondrial disintegration and sometimes protrusion of endothelial cell cytoplasm herniating into the blood vessel lumen. Chronic mercury intoxication resulted in distorted endothelial cells with an increase in the density of their cytoplasm. An altered vascular permeability is likely to occur as the result of the morphological changes.
D000814:Aniline Compounds / Q000494:pharmacology; D000818:Animals; D001152:Arsenicals / Q000494:pharmacology*; D001808:Blood Vessels / Q000187:drug effects* / Q000648:ultrastructure; D003593:Cytoplasm / Q000648:ultrastructure; D007758:Ear, Inner / Q000098:blood supply* / Q000648:ultrastructure; D004727:Endothelium / Q000648:ultrastructure; D006168:Guinea Pigs; D008630:Mercury Poisoning / Q000473:pathology*; D008928:Mitochondria / Q000648:ultrastructure
D000814:Aniline Compounds; D001152:Arsenicals