title: Effects of selenium and vitamin E deficiencies on reproduction, growth, blood components, and tissue lesions in sheep fed purified diets.
abstract: Three 2 X 2 factorial experiments were conducted with sheep fed purified diets to determine the effects of selenium and vitamin E on the incidence of white muscle disease (WMD) and blood components. All lambs reaching 6 weeks of age in the group receiving no vitamin E or selenium developed WMD lesions, whereas only a few lambs in either the +E - Se or -E + Se treatment groups developed these lesions. Plasma activities of creatine phosphokinase, lactic dehydrogenase and glutamic oxaloacetic transaminase were significantly elevated in lambs receiving no vitamin E or selenium, whereas these enzyme activities in those receiving only selenium were non-significantly elevated. The enzyme activities in plasma of those on the +E - Se or +E + Se treatments were maintained at low levels, suggesting vitamin E alone is more effective in preventing WMD than selenium alone. The metabolic interactions of these essentials are discussed.
mesh_terms: D000367:Age Factors; D000818:Animals; D001219:Aspartate Aminotransferases / Q000097:blood; D001724:Birth Weight; D003402:Creatine Kinase / Q000097:blood; D005260:Female; D005313:Fetal Death; D007770:L-Lactate Dehydrogenase / Q000097:blood; D008098:Litter Size; D009137:Muscular Dystrophy, Animal / Q000209:etiology; D011247:Pregnancy; D011248:Pregnancy Complications / Q000378:metabolism*; D012098:Reproduction; D012643:Selenium / Q000172:deficiency* / Q000378:metabolism; D012756:Sheep / Q000378:metabolism*; D014810:Vitamin E / Q000097:blood; D014811:Vitamin E Deficiency / Q000150:complications / Q000503:physiopathology*; D014912:White Muscle Disease / Q000209:etiology
chemical_list: D014810:Vitamin E; D007770:L-Lactate Dehydrogenase; D001219:Aspartate Aminotransferases; D003402:Creatine Kinase; D012643:Selenium