Prospective study of angiotensin II response to positional change in pregnancy-induced hypertension.
The response of endogenous angiotensin II levels to positional change, lateral to supine recumbency, was investigated in a prospective study of 55 primigravid patients during the last half of pregnancy. Blood samples were obtained in the lateral and supine recumbent positions. The mean supine angiotensin II level was significantly higher between 29 and 34 weeks' gestation in those patients destined to develop pregnancy-induced hypertension than in those who remained normotensive (P less than 0.05). As gestation advanced, the mean per cent relative change of angiotensin II from the lateral to the supine position altered from negative to positive in those patients destined to develop pregnancy-induced hypertension, whereas it remained negative in those patients who remained normotensive. These findings are discussed in relation to pathophysiologic alterations in the development of pregnancy-induced hypertension.
D000804:Angiotensin II / Q000097:blood*; D005260:Female; D006706:Homeostasis; D006801:Humans; D006973:Hypertension / Q000097:blood* / Q000503:physiopathology; D010920:Placenta / Q000503:physiopathology; D011187:Posture; D011247:Pregnancy; D011249:Pregnancy Complications, Cardiovascular / Q000097:blood* / Q000503:physiopathology; D011446:Prospective Studies; D013997:Time Factors; D014599:Uterus / Q000503:physiopathology
D000804:Angiotensin II