Effects of terbutaline on the pregnant baboon and fetus.
The effects of terbutaline on the mother and fetus were evaluated in 8 near-term pregnant baboons. Significant suppression of postoperative spontaneous and oxytocin-augmented uterine activity was achieved with infusion rates of 0.36 and 0.56 microgram/kg/min, respectively. Maternal and fetal blood pressure and acid-base states as well as fetal heart rate were unaffected by the administration of terbutaline to the mother, but a mild maternal tachycardia was observed. Both maternal and fetal blood glucose increased during terbutaline infusion. Direct administration of terbutaline to the fetus did not alter the fetal cardiovascular or acid-base state. It is concluded that in the baboon, terbutaline is an effective tocolytic agent with minimal untoward effects on either mother or fetus.
D000136:Acid-Base Equilibrium / Q000187:drug effects; D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D004305:Dose-Response Relationship, Drug; D005260:Female; D005333:Fetus / Q000187:drug effects*; D006439:Hemodynamics / Q000187:drug effects; D010121:Oxytocin / Q000008:administration & dosage; D010215:Papio; D011247:Pregnancy; D011270:Pregnancy, Animal / Q000187:drug effects*; D013726:Terbutaline / Q000008:administration & dosage / Q000494:pharmacology*; D014590:Uterine Contraction / Q000187:drug effects
D001786:Blood Glucose; D010121:Oxytocin; D013726:Terbutaline