Effects of testosterone propionate and environmental temperature on nitrogen balance and wound healing of rats with and without femoral fracture.
Testosterone exerted a sparing effect on nitrogen urinary excretion and balance in pair-fed rats with femoral fracture, dorsal skin incision, and subcutaneously implanted polyvinyl alcohol sponges, whether kept at 22 or 30 degrees C for 1 week postoperatively. No difference in 14-or 21-day wounds was observed among rats with dorsal skin incision and sponge implants, kept at 22 degrees, and starting immediately after operation, given daily IM injections of either 3 mg or 1 mg testosterone propionate in peanut oil, compared with similarly wounded rats given saline or peanut oil injections. Wound healing was impaired in rats kept at 22 degrees for 7 days following a skin incision, sponge implants, and femoral fracture. Testosterone administration begun immediately after operation, 2 mg/day subcutaneously, did not improve the impaired healing of pair-fed rats with fracture compared with rats without fracture. There was somewhat less collagen and a higher ratio of ground substance to collagen in the skin incisions and sponge granulomas of the testosterone group. No differences in wound healing were observed in pair-fed rats moved to a 30 degrees room postoperatively, among rats with or without fracture, nor among rats with femoral fracture given testosterone or saline subcutaneously.
D000818:Animals; D010367:Arachis; D003094:Collagen / Q000378:metabolism; D005264:Femoral Fractures / Q000378:metabolism / Q000503:physiopathology*; D005347:Fibroblasts; D006909:Hydroxyproline / Q000378:metabolism; D007279:Injections, Subcutaneous; D009584:Nitrogen / Q000378:metabolism / Q000652:urine; D009821:Oils / Q000494:pharmacology; D011188:Potassium / Q000378:metabolism; D051381:Rats; D012964:Sodium / Q000378:metabolism; D012965:Sodium Chloride / Q000494:pharmacology; D013696:Temperature; D013739:Testosterone / Q000008:administration & dosage / Q000494:pharmacology*; D014945:Wound Healing / Q000187:drug effects*
D009821:Oils; D013739:Testosterone; D012965:Sodium Chloride; D003094:Collagen; D012964:Sodium; D009584:Nitrogen; D006909:Hydroxyproline; D011188:Potassium