title: Effects of tranylcypromine and pargyline on brain tryptamine.
abstract: Tranylcypromine produces behavioral excitation while pargyline produces depression. Tranylcypromine increased brain tryptophan which led to an accumulation of tryptamine. The levels of tryptamine after tranylcypromine were found to be 3 times those found after pargyline.
mesh_terms: D000818:Animals; D001921:Brain / Q000187:drug effects / Q000378:metabolism*; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D010293:Pargyline / Q000494:pharmacology*; D014191:Tranylcypromine / Q000494:pharmacology*; D014363:Tryptamines / Q000378:metabolism*; D014364:Tryptophan / Q000494:pharmacology; D014439:Tyramine / Q000378:metabolism
chemical_list: D014363:Tryptamines; D014191:Tranylcypromine; D014364:Tryptophan; D010293:Pargyline; D014439:Tyramine