Placental transfer of a large angiotensin fragment in the guinea pig.
Angiotensin II (AII) levels are usually higher in the fetal than in the maternal circulations. Radioiodinated AII has been used to establish whether or not this hormone crosses the placenta from the fetus to the mother in the pregnant guinea pig. No intact radioiodinated AII was found to have crossed in any of 13 experiments. A single radioiodinated AII fragment was found in 10 of these experiments. This ran as (des-(Asp1 Arg2 Val3)) in one solvent, but this could not be confirmed when a different solvent was used. The results support the hypothesis, previously based on indirect evidence, that AII does not cross the placenta.
D000804:Angiotensin II / Q000378:metabolism*; D000818:Animals; D005260:Female; D006168:Guinea Pigs; D008431:Maternal-Fetal Exchange; D010446:Peptide Fragments / Q000378:metabolism*; D010920:Placenta / Q000378:metabolism*; D011247:Pregnancy
D010446:Peptide Fragments; D000804:Angiotensin II