Lymphocytes which differentiate in an allogeneic thymus. II. Evidence for both central and peripheral mechanisms in tolerance to donor strain tissues.
Nude mice which have been grafted with an allogeneic H-2-incompatible thymus are frequently specifically tolerant to skin grafts from the thymus donor strain. The evidence presented here indicates that both clonal deletion and peripheral suppressor cells play a part in maintaining this tolerance.
D000818:Animals; D002454:Cell Differentiation; D002999:Clone Cells / Q000276:immunology; D004848:Epithelium / Q000637:transplantation; D007108:Immune Tolerance; D007116:Immunization, Passive; D007165:Immunosuppression Therapy; D008214:Lymphocytes / Q000166:cytology*; D051379:Mice; D008807:Mice, Inbred BALB C; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D008811:Mice, Inbred DBA; D008819:Mice, Nude; D013950:Thymus Gland / Q000166:cytology* / Q000473:pathology / Q000637:transplantation; D014184:Transplantation, Homologous