title: [Hemoperfusion with coated activated charcoal for treating acute poisoning by remedies, plant protectants, and fungi (author's transl)].
abstract: From the clinico-toxicological standpoint, the most important plant protectants are the insecticides (bipyridylium compounds). In vitro trials and investigations on poisoned patients have shown that it is fundamentally possible to eliminate such plant protectants from the blood by hemoperfusion with coated activated charcoal. With both the lipophilic alkyl phosphate, nitrostigmine (E605 forte), and by the two hydrophilic alkyl phosphates, demetone-S-methyl sulfoxide (Metasystox R) and dimethoate (Roxion), it was possible to measure hemoperfusion clearance values around 60 to 85 ml/min at a blood flow rate of 100 ml/min. Only the two hydrophilic alkyl phosphates were able to be eliminated by hemodialysis, the clearance values being, however, lower. Thus in severe alkyl phosphate intoxications the use of hemoperfusion may considered alongside the standard therapy. The bipyridylium compounds, paraquat (Gramoxone) and diquat (Reglone), are readily dialysed, but can be better eliminated from the blood by hemoperfusion. This therapeutic measure must be initiated as rapidly as possible independent of the clinical picture, for only when hemoperfusion is begun prior to the fixation of paraquat or diquat at tissue are there any prospects of success.
mesh_terms: D015082:2,2'-Dipyridyl / Q000506:poisoning; D000328:Adult; D002606:Charcoal / Q000627:therapeutic use*; D004117:Dimethoate / Q000506:poisoning; D006540:Herbicides / Q000506:poisoning; D006801:Humans; D007306:Insecticides / Q000506:poisoning; D008297:Male; D010269:Paraquat / Q000506:poisoning; D010477:Perfusion / Q000379:methods*; D010575:Pesticides / Q000506:poisoning*; D013997:Time Factors
chemical_list: D006540:Herbicides; D007306:Insecticides; D010575:Pesticides; D002606:Charcoal; D015082:2,2'-Dipyridyl; D010269:Paraquat; D004117:Dimethoate
vernacular_title: Hämoperfusion mit beschichteter Aktivkohle zur Behandlung akuter Intoxikationen durch Arzneimittel, Pflanzenschutzmittel oder Pilze. II. Pflanzenschutzmittel