Enhancement of hydralazine bioavailability by food.
The influence of food on the bioavailability of hydralazine in noncoated and coated tablets was examined in 5 healthy males. Each subject received an oral 50-mg dose on four different occasions: two 25-mg noncoated tablets with and without food and one 50-mg coated tablet with and without food. The meal was a standardized breakfast of 440 calories. Venous blood samples were obtained during a 6-hr period, and the plasma concentrations of unmetabolized hydralazine were assessed by a selective and sensitive gas chromatographic method. The results indicate that food enhances the bioavailability of hydralazine 2- to 3-fold both when noncoated and coated tablets are used.
D000328:Adult; D001682:Biological Availability; D005502:Food; D006801:Humans; D006830:Hydralazine / Q000008:administration & dosage / Q000097:blood*; D007700:Kinetics; D008297:Male; D013607:Tablets; D013997:Time Factors
D013607:Tablets; D006830:Hydralazine