Ultraviolet-induced DNA-repair synthesis in lymphocytes from patients with chronic lymphatic leukemia.
Ultraviolet-induced DNA-repair synthesis was studied in peripheral lymphocytes from 10 patients with chronic lymphatic leukemia (CLL). An ultraviolet-dose curve was established for each patient and compared with curves for healthy individuals. The same level of DNA-repair synthesis was recorded in CLL and normal lymphocytes. This contrasts with a report from another laboratory. Evidence is presented of the necessity of inhibiting replicative DNA-synthesis with hydroxyurea in order to adequately estimate the DNA-repair synthesis.
D000368:Aged; D004260:DNA Repair / Q000528:radiation effects*; D004261:DNA Replication; D004273:DNA, Neoplasm / Q000096:biosynthesis*; D005260:Female; D006801:Humans; D006918:Hydroxyurea / Q000494:pharmacology; D007945:Leukemia, Lymphoid / Q000378:metabolism*; D008214:Lymphocytes / Q000187:drug effects / Q000378:metabolism* / Q000528:radiation effects; D008297:Male; D008875:Middle Aged; D013936:Thymidine / Q000378:metabolism; D014466:Ultraviolet Rays
D004273:DNA, Neoplasm; D013936:Thymidine; D006918:Hydroxyurea