Identification of 3-methyl-2-thiohydantoin, a metabolite of carbimazole, in man.
1. Classical and high-pressure liquid chromatographic separations were devised for the separation and isolation of the metabolite 3-methyl-2-thiohydantoin from the urine of patients receiving carbimazole orally. 2. 3-methyl-2-thiohydantoin was identified by comparing its absorption and mass spectral properties with authentic material. 3. 3-methyl-2-thiohydantoin was also detected in the plasma of patients receiving methimazole intravenously.
D002231:Carbimazole / Q000378:metabolism*; D002851:Chromatography, High Pressure Liquid; D006801:Humans; D006827:Hydantoins / Q000652:urine*; D013058:Mass Spectrometry; D008713:Methimazole / Q000378:metabolism; D013056:Spectrophotometry, Ultraviolet; D013867:Thiohydantoins / Q000652:urine*
D006827:Hydantoins; D013867:Thiohydantoins; D008713:Methimazole; D002231:Carbimazole