The influence of oral penicillamine and diet on lead poisoning in rats.
In spite of continued lead intake, the oral chelate d-penicillamine was effective in reducing blood lead levels of lead-poisoned weanling rats on three different low-residue diets: a standard rat diet, a low calcium diet, and the trace metal salt modified EPA diet. A significant lessening of weight gain was evident in those on the low calcium diet.
D000818:Animals; D002118:Calcium / Q000008:administration & dosage; D005260:Female; D007854:Lead / Q000097:blood; D007855:Lead Poisoning / Q000097:blood / Q000178:diet therapy* / Q000188:drug therapy; D010396:Penicillamine / Q000627:therapeutic use*; D010758:Phosphorus / Q000008:administration & dosage; D051381:Rats; D014131:Trace Elements / Q000008:administration & dosage
D014131:Trace Elements; D010758:Phosphorus; D007854:Lead; D010396:Penicillamine; D002118:Calcium