[Histological and ultramicroscopic aspects of the small intestine in aregenerative enteropathies after treatment with 2-mercapto-propionyl-glycine (Thiola)].
The results of using alpha-mercapto-propionyl-glycine treatment (500 mg i.v. pro die for a time varying from one to four months) in a group of 25 patients suffering from aregenerative enteropathy with differing aetiopathogenesis are reported and compared with 29 control patients, i.e. patients suffering from the same situation and not treated with the drug. Morphological (by optical and electronic microscope) and functional (absorption of oleic acid, xylose and B12) study of the small intestine showed up the effectiveness of alpha-mercapto-propionyl-glycine on the trophism of small intestine mucosa, by way of normalization of intestinal cytokinetics, in aregenerative enteropathies due to special physiopathological situations (gastroresection) or to drugs (cytostatics, etc.) inhibiting enterocytic regeneration.
D000603:Amino Acids, Sulfur / Q000627:therapeutic use*; D006801:Humans; D007410:Intestinal Diseases / Q000188:drug therapy* / Q000473:pathology; D007421:Intestine, Small / Q000473:pathology; D008625:Tiopronin / Q000627:therapeutic use*
D000603:Amino Acids, Sulfur; D008625:Tiopronin
Aspetti istologici ed ultramicroscopici dell'intestino tenue nelle enteropatie arigenerative dopo trattamento con 2-mercapto-propionil-glicina (Thiola).