Effect of different doses of BCG on an allogeneic cell-mediated antitumor response in mice.
The effect of BCG on the development of cell-mediated cytotoxicity (CMC) in the spleens of allogeneic tumor-bearing (C57BL/6 X A)F1 mice was studied. BCG-treated tumor-bearing animals elicited a stronger CMC response than did the untreated tumor-bearing animals. Furthermore, the degree of activation was dependent on different doses of BCG, so that if the BCG was administered at doses above or below the optimum dose, a less marked stimulation of the CMC resulted. The combination of BCG given before the tumor implant plus an intratumor inoculation resulted in a significantly higher CMC than did either treatment alone.
D000818:Animals; D001500:BCG Vaccine / Q000008:administration & dosage* / Q000494:pharmacology; D003601:Cytotoxicity Tests, Immunologic; D004306:Dose-Response Relationship, Immunologic; D005260:Female; D007111:Immunity, Cellular; D051379:Mice; D008805:Mice, Inbred A; D008810:Mice, Inbred C57BL; D009368:Neoplasm Transplantation; D009374:Neoplasms, Experimental / Q000276:immunology / Q000628:therapy*; D013154:Spleen / Q000276:immunology; D014184:Transplantation, Homologous
D001500:BCG Vaccine