title: Spectral changes resulting from the interaction of some N-alkyl nitrosamines and rat liver microsomes.
abstract: Dimethyl (DMN) and diethyl nitrosamine (DEN) do not give characteristic spectral changes upon interaction with rat liver microsomes, while dipropyl (DPN) and dibutyl (DBN) nitrosamine cause type I spectral changes. The spectral binding constant is 100 mM for DPN and 1.17 mM for DBN. The maximal spectral change is 3.2 X 10(6) and 1.0 X 10(6) absorbance units per milligram protein for DPN and DBN respectively.
mesh_terms: D000818:Animals; D004052:Diethylnitrosamine / Q000378:metabolism*; D004128:Dimethylnitrosamine / Q000378:metabolism*; D007700:Kinetics; D008297:Male; D008862:Microsomes, Liver / Q000378:metabolism*; D009602:Nitrosamines / Q000378:metabolism*; D051381:Rats; D013053:Spectrophotometry; D013329:Structure-Activity Relationship
chemical_list: D009602:Nitrosamines; D004052:Diethylnitrosamine; D004128:Dimethylnitrosamine