title: [Synthesis and pharmacological study of various 2-(alkylaminoalkyl)mercapto-5-aryl-1,3,4-oxadiazoles].
abstract: Work was continued on the pharmacological study of the 1,3,4-oxadiazole nucleus using aroylhydrazines already used for the synthesis of anti-MAO compounds. S-alkylaminoalkyl derivatives of some 2-mercapto-5-aryl-1,3,4-oxadiazoles were prepared bearing in the 5-position a 3,4,5-trimethoxyphenyl, a 3,5-dimethoxy-4-ethoxyphenyl or a 3,4-dihydroxymethylenephenyl radical. When subjected to pharmacological investigation the compounds showed clear hypotensive activity partially antagonized by atropine and antispastic activity on smooth muscle.
mesh_terms: D000818:Animals; D000959:Antihypertensive Agents / Q000138:chemical synthesis*; D001794:Blood Pressure / Q000187:drug effects; D055598:Chemical Phenomena; D002621:Chemistry; D006168:Guinea Pigs; D007082:Ileum / Q000187:drug effects; D008297:Male; D051379:Mice; D009130:Muscle, Smooth / Q000187:drug effects; D010069:Oxadiazoles / Q000138:chemical synthesis* / Q000494:pharmacology; D011817:Rabbits; D051381:Rats
chemical_list: D000959:Antihypertensive Agents; D010069:Oxadiazoles
vernacular_title: Sintesi ed attività farmacologica di alcuni 2-(alchilamminoalchil)mercapto-5-aril-1,3,4-ossadiazoli.