The identification of two novel prostaglandins and a thromboxane.
6,15-Dioxo-PGF1alpha, 6,15-dioxo-13,14-dihydro-PGF1alpha and 15-oxo-thromboxane B2 have been identified in incubates of ram seminal vesicle homogenates with added arachidonic acid or in the perfusate from sensitised challenged guinea pig lungs. These compounds are probably related to 6-oxo-PGF1alpha and thromboxane B2. The structures have been determined by gas chromatography mass spectrometry, following suitable chemical derivatisation.
D000818:Animals; D001095:Arachidonic Acids; D055598:Chemical Phenomena; D002621:Chemistry; D002849:Chromatography, Gas; D006168:Guinea Pigs; D006880:Hydroxy Acids / Q000032:analysis*; D007202:Indicators and Reagents; D008168:Lung / Q000032:analysis; D008297:Male; D013058:Mass Spectrometry; D010477:Perfusion; D011460:Prostaglandins F / Q000032:analysis*; D011714:Pyrans / Q000032:analysis; D012669:Seminal Vesicles / Q000032:analysis; D012756:Sheep; D012824:Silicic Acid
D001095:Arachidonic Acids; D006880:Hydroxy Acids; D007202:Indicators and Reagents; D011460:Prostaglandins F; D011714:Pyrans; D012824:Silicic Acid