title: Delayed appearance of propranolol sensitivity in cultured heart cells.
abstract: Examination of the appearance of adrenaline responsiveness and propranolol sensitivity with culture age in myoblasts cultured from neonatal rat hearts shows that propranolol sensitivity lags behind adrenergic responsiveness. Such a finding may illustrate subtle differences in sites for agonist and antagonist at the beta-receptor of these cells.
mesh_terms: D000818:Animals; D000831:Animals, Newborn; D002478:Cells, Cultured; D004837:Epinephrine / Q000494:pharmacology; D006339:Heart Rate / Q000187:drug effects*; D011217:Practolol / Q000494:pharmacology; D011433:Propranolol / Q000494:pharmacology*; D051381:Rats; D013997:Time Factors
chemical_list: D011433:Propranolol; D011217:Practolol; D004837:Epinephrine