Hypoketonaemic effect of L-alamine. Specific decrease in blood concentrations of 3-hydroxybutyrate in the rat.
1. The injection of L-alanine (50-100 mg/kg) into 35-day-old rats that had been starveed for 48 h increased blood L-alanine concentration to values observed in fed animals and lowered the blood concentration of 3-hydroxybutyrate within 2 min. 2. This hypoketon aemic action of L-alanine was specific for 3-hydroxybutyrate, since the acetoacetate concentrations did not change significantly. 3. The decrease in 3-hydroxybutyrate elicited by L-alanine was not related to changes in the blood concentrations of insulin, glucagon, growth hormone, glucose, unesterified fatty acids, lactate or pyruvate. 4. The injection of L-alanine resulted in a decrease in total ketones that was apparently unrelated to their increased peripheral utilization. These results are interpreted as an anti-ketogenic action of L-alanine. 5. The data suggest that L-alamine lowers ketone-body formation in starved rats, possibly via an alteration in hepatic redox equilibrium.
D000085:Acetates / Q000494:pharmacology; D000090:Acetoacetates / Q000097:blood; D000409:Alanine / Q000494:pharmacology*; D000818:Animals; D001786:Blood Glucose / Q000032:analysis; D005230:Fatty Acids, Nonesterified / Q000097:blood; D005260:Female; D006728:Hormones / Q000097:blood; D006885:Hydroxybutyrates / Q000097:blood*; D007657:Ketone Bodies / Q000097:blood*; D007773:Lactates / Q000097:blood; D008297:Male; D011773:Pyruvates / Q000097:blood; D051381:Rats
D000085:Acetates; D000090:Acetoacetates; D001786:Blood Glucose; D005230:Fatty Acids, Nonesterified; D006728:Hormones; D006885:Hydroxybutyrates; D007657:Ketone Bodies; D007773:Lactates; D011773:Pyruvates; D000409:Alanine