title: Can the singularity of chronic peptic ulcers be described by catastrophe theory and explained by biofeedback?
abstract: The damaging effect of hydrochloric acid within the lumen of the stomach and duodenum should be diffuse, but chronic peptic ulcers are discrete and usually single. The search for localizing effects on acid attack, or localized defects in mucosal defense have so far been fruitless. If attacking forces increase, or mucosal defense diminishes to the point where ulceration occurs, mucosal breakdown should be progressive. In chronic peptic ulceration, however, the process usually seems to be self-limiting. The catastrophe theory of René Thom may describe the progressive change in the forces that leads to eventual breakdown in mucosal continuity. Possibly this catastrophe triggers off biofeedback mechanisms that hold in check further progress of the ulcer.
mesh_terms: D002908:Chronic Disease; D005246:Feedback; D005750:Gastric Juice / Q000378:metabolism / Q000502:physiology; D005753:Gastric Mucosa / Q000503:physiopathology; D006801:Humans; D010437:Peptic Ulcer / Q000209:etiology / Q000473:pathology / Q000503:physiopathology*; D011338:Probability Theory