Estrogen hormones and lipid metabolism. Effect of ethynyl-estradiol on liver lipases.
Lipase activities assayed in liver subcellular fractions from rats given ethynyl-estradiol are lowered, while triglycerides increase and cholesterol decreases in blood. Triester lipase in microsomes is the most altered activity. Such enzymatic changes might play a role in the development of lipid abnormalities in blood of women taking estrogens as oral contraceptives.
D000818:Animals; D002784:Cholesterol / Q000097:blood; D004997:Ethinyl Estradiol / Q000494:pharmacology*; D005260:Female; D008049:Lipase / Q000378:metabolism*; D008099:Liver / Q000187:drug effects* / Q000201:enzymology; D051381:Rats; D013347:Subcellular Fractions / Q000201:enzymology; D014280:Triglycerides / Q000097:blood
D014280:Triglycerides; D004997:Ethinyl Estradiol; D002784:Cholesterol; D008049:Lipase