title: Fractures in children treated with methotrexate for leukemia.
abstract: Multiple fractures occurred in 7 children treated with methotrexate for leukemia. Non-union or delayed union in spite of adequate immobilization also occurred in children on methotrexate. When the methotrexate was discontinued the fractures usually healed. Methotrexate appears to be a drug which inhibits osteogenesis, and may be promising in heterotopic ossification and related orthopedic conditions.
mesh_terms: D002648:Child; D005260:Female; D005592:Fracture Fixation; D050723:Fractures, Bone / Q000209:etiology*; D006801:Humans; D007938:Leukemia / Q000188:drug therapy; D008727:Methotrexate / Q000009:adverse effects* / Q000627:therapeutic use; D010024:Osteoporosis / Q000139:chemically induced / Q000150:complications
chemical_list: D008727:Methotrexate