[Decrease in the tissue-specific resistance of gastric epithelium to acute cell death following inhibition of DNA synthesis].
Administration to mice of hydroxyurea caused an acute death of an insignificant number of DNA-synthesizing cells in the epithelium of the glandular stomach. When actinomycin D was injected 8 hours prior to hydroxyurea there occurred a sharp intensification of cell degeneration: about 80% of the cells which synthesized DNA during the hydroxyurea administration proved to degenerate. No intensifying action was produced when actinomycin D was injected simultaneously with hydroxyruea. It is supposed that actinomycin D intensified the protein synthesis in the cells of the stomach (the "superinduction" effect), this increasing their sensitivity to the inhibition of the DNA synthesis.
D000818:Animals; D002470:Cell Survival / Q000187:drug effects; D004247:DNA / Q000096:biosynthesis*; D003609:Dactinomycin / Q000494:pharmacology; D004347:Drug Interactions; D004848:Epithelium; D005753:Gastric Mucosa / Q000166:cytology*; D006918:Hydroxyurea / Q000494:pharmacology*; D051379:Mice; D009928:Organ Specificity
D003609:Dactinomycin; D004247:DNA; D006918:Hydroxyurea
Umen'shenie tkanevospetsificheskoĭ ustoĭchivosti épiteliia zheludka k ostroĭ gibeli kletok pri tormozhenii sinteza DNK