The prostatic lobes and the seminal vesicles in non-diabetic and alloxan-diabetic castrated adrenalectomized rats injected with cortisone.
The growth of the prostatic lobes and the seminal vesicles was studied morphologically in alloxan-diabetic and non-diabetic castrated adrenalectomized rats. In non-diabetic but not in alloxan-diabetic rats cortisone in daily doses of 3 or 6 mg induced growth and secretory activity in the epithelium of the dorsolateral prostate, the coagulating glands and the seminal vesicles. Insulin administration to alloxan-diabetic rats could restore the effect of cortisone on these glands. This indicates that insulin deficiency per se was the main reason for the failure of cortisone to induce secretory activity of the prostatic lobes and the seminal vesicles of alloxan-diabetic rats.
D000315:Adrenalectomy; D000818:Animals; D001835:Body Weight / Q000187:drug effects; D002369:Castration; D003348:Cortisone / Q000494:pharmacology*; D003921:Diabetes Mellitus, Experimental / Q000473:pathology*; D007328:Insulin / Q000494:pharmacology; D008297:Male; D009929:Organ Size / Q000187:drug effects; D011467:Prostate / Q000187:drug effects*; D051381:Rats; D012669:Seminal Vesicles / Q000187:drug effects*
D007328:Insulin; D003348:Cortisone