[On the possibility of reducing systemic side-effects of isoproterenol eyedrops by means of topical propranolol (author's transl)].
Topical administration of Isoproterenol reduces the intraocular pressure in glaucomatous eyes, but produces systemic side-effects (tachycardia arterial hypotension) that make its clinical use unadvisable. Such side-effects are significant when the concentration of Isoproterenol is 4 and 5%. Pre-treatment of the contralateral eye with a solution of Propranolol 1%, 30 and 60 min. before Isoproterenol instillation, markedly reduces systemic side-effects, without diminishing the ocular hypotensive effectiveness.
D000293:Adolescent; D000328:Adult; D005901:Glaucoma / Q000188:drug therapy / Q000503:physiopathology; D006801:Humans; D007429:Intraocular Pressure / Q000187:drug effects; D007545:Isoproterenol / Q000009:adverse effects* / Q000037:antagonists & inhibitors / Q000627:therapeutic use; D009883:Ophthalmic Solutions; D011433:Propranolol / Q000008:administration & dosage / Q000494:pharmacology*
D009883:Ophthalmic Solutions; D011433:Propranolol; D007545:Isoproterenol
Uber die Möglichkeit, die systemischen Nebenwirkungen der Augentropfen Isoproterenol durch lokale Verabreichung von Propranolol zu verhindern.