Modulation of heroin self-administration by neurohypophyseal principles.
Neuropeptides related to hypothalomic-neurohypophyseal hormones affect intravenous heroin self-administration behavior in rats. Desglycinamide9, arginine8-vasopressin and pressinamide reduced, while oxytocin and its C-terminal tripeptide, prolyl-leucyl-glycinamide facilitated this behavior. The effectiveness of the vasopressin analogue appeared to be of a long term nature. The data indicate a modulating effect of these principles on the reinforcing efficacy of heroin.
D000818:Animals; D001127:Arginine Vasopressin / Q000031:analogs & derivatives / Q000494:pharmacology; D003932:Heroin / Q000008:administration & dosage*; D008297:Male; D010121:Oxytocin / Q000031:analogs & derivatives / Q000494:pharmacology; D010446:Peptide Fragments / Q000494:pharmacology; D010909:Pituitary Hormones, Posterior / Q000494:pharmacology*; D051381:Rats; D012646:Self Administration; D013997:Time Factors
D010446:Peptide Fragments; D010909:Pituitary Hormones, Posterior; D001127:Arginine Vasopressin; D010121:Oxytocin; D003932:Heroin