A new major projection from locus coeruleus: the main source of noradrenergic nerve terminals in the ventral and dorsal columns of the spinal cord.
Almost all catecholamine (CA)-containing nerve terminals in the ventral column, intermediate grey and ventral half of the dorsal column disappeared after bilateral stereotaxic lesions of nucleus locus coeruleus, as revealed by fluorescence histochemistry. Some of the CA nerve terminals in the dorsal half of the column seemed to be unaffected by the lesions, as well as the CA terminals innervating the thoracic sympathetic lateral column and the band of nerve terminals crossing the midline and innervating the central grey. This coeruleo-spinal pathway in the rat is located in the anterior funiculus and the ventral parts of the lateral funiculus. A schematic map of the different CA projections to the spinal cord is presented. It was concluded that locus coeruleus innervates almost all parts of the central nervous system.
D000818:Animals; D002395:Catecholamines / Q000032:analysis*; D002552:Cerebral Ventricles / Q000502:physiology*; D006651:Histocytochemistry; D008297:Male; D009410:Nerve Degeneration; D009434:Neural Pathways; D009638:Norepinephrine / Q000032:analysis; D051381:Rats; D013116:Spinal Cord / Q000032:analysis / Q000502:physiology*
D002395:Catecholamines; D009638:Norepinephrine