Potentiation of d-tubocurarine (d-Tc) neuromuscular blockade in cats by lithium chloride.
I.v. infusion of LiCl at 1.0 mEq/0.25 ml/min produced significant decrease in plasma Na+ from 158 +/- 4.5 mEq/l (p less than 0.025) and in Ca2+ from 7.8 +/- 0.34 to 6.8 +/- 0.24 mg% (p less than 0.01) with insignificant increase in K+. No significant changes in plasma electrolytes were observed on infusion of NaCl. The d-Tc induced neuromuscular blockade in Li Cl infused animals was significantly greater than that in Na Cl infused ones.
D000818:Animals; D002118:Calcium / Q000097:blood; D002415:Cats; D004357:Drug Synergism; D005260:Female; D008094:Lithium / Q000097:blood / Q000494:pharmacology*; D008297:Male; D009119:Muscle Contraction / Q000187:drug effects; D009469:Neuromuscular Junction / Q000187:drug effects*; D011188:Potassium / Q000097:blood; D012964:Sodium / Q000097:blood; D014403:Tubocurarine / Q000494:pharmacology*
D008094:Lithium; D012964:Sodium; D011188:Potassium; D002118:Calcium; D014403:Tubocurarine