title: [Local use of levomycetin in neurosurgery].
abstract: A method of local application of the unsoluble medicinal form of chloramphenicol during operations has been developed. Administration of the preparation in a dose up to 2g under an osteal or cutaneous graft induces no side complications and forms a depot of the agent therapeutic concentrations for more than 8 days. There exists a direct relationship between the increasing of staphylococcus resistance to chloramphenicol and the quantity of the agent used in patients.
mesh_terms: D002701:Chloramphenicol / Q000008:administration & dosage* / Q000134:cerebrospinal fluid; D006801:Humans; D010911:Pituitary Neoplasms / Q000517:prevention & control*; D013203:Staphylococcal Infections / Q000517:prevention & control*; D013530:Surgical Wound Infection / Q000517:prevention & control*
chemical_list: D002701:Chloramphenicol
vernacular_title: Mestnoe primenenie levomitsetina v neĭrokhirurgii.