Uptake of labeled dianhydrogalactitol into human gliomas and nervous tissue.
The distribution of iv administered 3H-dianhydrogalactitol (DAG) in the plasma, cerebrospinal fluid (CSF), brain, and tumor tissue was studied in 11 patients. DAG entered the CSF and was slowly eliminated, with a half-life of 20 hours. Unchanged DAG accounted for about 6%-30% of the total radioactivity in the CSF. All the tumors accumulated the drug to a higher extent than the intact white matter, except the one meningioma studied. The highest uptake was observed in the relatively benign astrocytic tumors.
D000328:Adult; D001921:Brain / Q000378:metabolism; D004988:Ethers, Cyclic / Q000134:cerebrospinal fluid / Q000378:metabolism; D004376:Galactitol / Q000031:analogs & derivatives / Q000134:cerebrospinal fluid / Q000378:metabolism*; D005910:Glioma / Q000378:metabolism*; D006207:Half-Life; D006801:Humans; D008875:Middle Aged; D009417:Nerve Tissue / Q000378:metabolism*; D013402:Sugar Alcohols / Q000378:metabolism*; D013997:Time Factors
D004988:Ethers, Cyclic; D013402:Sugar Alcohols; D004376:Galactitol