Vertical transmission of the virus of hepatitis B and neonatal hepatic cirrhosis in an Argentine family.
In a family in which the mother was a healthy HBsAg and anti HBc carrier, and the father had a chronic persistent hepatitis with anti HBs and anti HBc positive, the development of neonatal cirrhosis in two of the children was proved to be present. One of the girls was an anti HBs carrier (anti HBc was not determined) and the other had positive anti HBs and anti HBc. Both died and the diagnosis of cirrhosis was confirmed. The two healthy daughters were anti HBc carriers.
D000914:Antibodies, Viral / Q000302:isolation & purification; D000917:Antibody Formation; D001118:Argentina; D002353:Carrier State / Q000276:immunology*; D002648:Child; D002908:Chronic Disease; D005260:Female; D006505:Hepatitis / Q000635:transmission; D006509:Hepatitis B / Q000235:genetics* / Q000635:transmission; D006514:Hepatitis B Surface Antigens / Q000302:isolation & purification; D006515:Hepatitis B virus / Q000472:pathogenicity*; D006801:Humans; D007231:Infant, Newborn; D007232:Infant, Newborn, Diseases / Q000209:etiology; D008103:Liver Cirrhosis / Q000235:genetics* / Q000635:transmission; D008297:Male; D010375:Pedigree; D011247:Pregnancy
D000914:Antibodies, Viral; D006514:Hepatitis B Surface Antigens