Accelerating action of tea on mouse skin carcinogenesis.
The effect of different tannin-containing aqueous solutions on the carcinogenic action of benzo(a)pyrene (BP) on the mouse skin was investigated. It was found that the appearance of tumours was accelerated in mice treated with either tea or an oak extract after a single application of BP. The time of appearance of tumours in mice treated with gallic acid or tannic acid after treatment with BP was similar to that in the group treated with BP alone. The overall incidence of tumours was similar in all five groups.
D000818:Animals; D001580:Benzopyrenes / Q000633:toxicity; D004357:Drug Synergism; D005260:Female; D005707:Gallic Acid / Q000494:pharmacology; D047348:Hydrolyzable Tannins / Q000494:pharmacology; D008297:Male; D051379:Mice; D009374:Neoplasms, Experimental / Q000139:chemically induced; D012878:Skin Neoplasms / Q000139:chemically induced*; D013662:Tea / Q000633:toxicity*; D014934:Wood
D001580:Benzopyrenes; D047348:Hydrolyzable Tannins; D013662:Tea; D005707:Gallic Acid