The thyroidal production of reverse triiodothyronine in autonomous adenoma.
The ratios of reverse triiodothyronine (rT3) to triiodothyronine (T3) concentrations were similar (0.89 +/- 0.09) in twenty-three autonomous thyroid nodules (fourteen decompensated, nine compensated) and paranodular tissues (0.82 +/- 0.08), whereas the serum ratio was significantly lower (0.098 +/- 0.014). This is compatible with the hypothesis that thyroidal rT3 and T3 production from mono- and diiodotyrosine may be a random process in contrast to non-random extrathyroidal rT3 and T3 formation.
D000236:Adenoma / Q000378:metabolism*; D000328:Adult; D006801:Humans; D008875:Middle Aged; D013964:Thyroid Neoplasms / Q000378:metabolism*; D014284:Triiodothyronine / Q000096:biosynthesis* / Q000097:blood / Q000378:metabolism
D014284:Triiodothyronine