[Experimental investigations on the effect of various doses of streptokinase on blood viscosity (author's transl)].
The decrease in blood viscosity induced by streptokinase (SK) in the present investigation in proportional to the streptokinase concentration up to a concentration of 2000 IE/ml blood. A maximum decrease in viscosity is attained with a dosage of between 200 and 300 IE/ml blood. The decrease in viscosity is already clearly detectable at 10 minutes at all investigated doses and is completed after 20 to 30 minutes. An increase in SK resistance delays the decrease in viscosity. Prevention of the decrease, however, only seems to occur with a very high SK resistance and a very low SK dosage (50 IE/ml blood). The optimum dosage of SK to achieve a maximum decrease in viscosity is 200 IE/ml blood.
D001809:Blood Viscosity / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D006801:Humans; D013300:Streptokinase / Q000494:pharmacology*
D013300:Streptokinase
Experimentelle Untersuchungen über den Einfluss verschiedener Dosen von Strptokinase auf die Blutviskosität