title: Saralasin infusion in the recognition of renovascular hypertension.
abstract: Saralasin, an angiotensin II antagonist, was infused into 49 patients with renal artery stenosis, 10 patients with essential hypertension and normal renal arteriograms, and five patients with "low-renin essential hypertension." Renal venous renin and differential renal function studies were used to assess the functional significance of arterial stenoses. "Response" to saralasin, evidenced by a fall in blood pressure during infusion, occurred in no patients with "low renin" hypertension and in only 20% of patients with normal renal arteriograms. In contrast, saralasin "response" occurred in more than 80% of patients with renal artery stenosis and lateralizing functional studies and 100% of cases of "proven" renovascular hypertension (cure or improvement of hypertension after operative treatment). We suggest that saralasin infusion might be a valuable screening test for the recognition of renovascular hypertension.
mesh_terms: D000804:Angiotensin II / Q000031:analogs & derivatives*; D001794:Blood Pressure / Q000187:drug effects; D003937:Diagnosis, Differential; D006801:Humans; D006973:Hypertension / Q000175:diagnosis; D006977:Hypertension, Renal / Q000175:diagnosis* / Q000601:surgery; D009392:Nephrectomy; D012078:Renal Artery Obstruction / Q000175:diagnosis / Q000601:surgery; D012083:Renin / Q000097:blood; D012504:Saralasin
chemical_list: D000804:Angiotensin II; D012083:Renin; D012504:Saralasin