[Short term toxicity of ochratoxin A: some biochemical lesions in the rat (author's transl)].
The blood serum level of total proteins, urea, total lipids, cholesterol and glucose, and the excretion of nitrogen in the urine were estimated in control or treated rats. Male adult rats were given the toxin per os (0, 0.5, 1 or 2 mg/kg) during 10 days. An increase in the urinary volume was observed, with a decrease in the total nitrogen concentration. Blood total proteins and urea levels were higher than in control animals but total lipids and cholesterol levels dropped. Blood glucose concentration remained unaffected. These effects were evident even for the lowest dose and their intensity increased with the amount of toxin given to the animals. Statistical analysis showed significant differences between the results obtained in control animals and those obtained in animals treated with either 2 mg/kg or--except for blood urea--1 mg/kg.
D000818:Animals; D001798:Blood Proteins / Q000032:analysis; D001835:Body Weight; D006400:Hematocrit; D008297:Male; D009584:Nitrogen / Q000652:urine; D009793:Ochratoxins / Q000633:toxicity*; D051381:Rats
D001798:Blood Proteins; D009793:Ochratoxins; D009584:Nitrogen
Toxicité à court terme de l'ochratoxine A chez le rat. Quelques manifestations biochimiques de l'intoxication.