Serum immunoglobulin levels in cancer patients. III. Immunoglobulin levels and metastases of malignant tumors.
The levels of IgG, IgA and IgM were followed in 93 patients with metastases of various tumors in the liver, bones, lymph nodes, lungs and with the generalization of tumor in multiple organs. A significant increase of IgG was noted in those patients where liver, bones and lymph nodes were involved, compared to other tumor groups as well as with the values considered as normal range. A significant rise of the IgA class was observed in patients with liver metastases compared to cases with the generalization of tumor. In all groups the mean levels were scattered above the upper limit of normal values. The mean levels of IgM class did not exceed the upper normal limit, but in the group of bone metastases a significant rise was noted compared with the group of generalized tumors.
D000328:Adult; D000368:Aged; D001859:Bone Neoplasms / Q000276:immunology; D001943:Breast Neoplasms / Q000276:immunology; D005260:Female; D006801:Humans; D007070:Immunoglobulin A / Q000032:analysis*; D007074:Immunoglobulin G / Q000032:analysis*; D007075:Immunoglobulin M / Q000032:analysis*; D008113:Liver Neoplasms / Q000276:immunology; D008175:Lung Neoplasms / Q000276:immunology; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D009362:Neoplasm Metastasis / Q000276:immunology*
D007070:Immunoglobulin A; D007074:Immunoglobulin G; D007075:Immunoglobulin M