Parasympathomimetic effects of mono sodium glutamate.
The effects of Mono sodium glutamate on smooth muscles were studied using the guinea-pig isolated ileum. Mono sodium glutamate produced spasmogenic effect. Atropine blocked the contractile response elicited by Mono sodium glutamate whereas mepyramine and hexamethonium failed to do so. These findings suggest a cholinergic involvement at post ganglionic site of action.
D000818:Animals; D001285:Atropine / Q000494:pharmacology; D005971:Glutamates / Q000494:pharmacology*; D006168:Guinea Pigs; D006584:Hexamethonium Compounds / Q000494:pharmacology; D007082:Ileum / Q000502:physiology; D066298:In Vitro Techniques; D009119:Muscle Contraction / Q000187:drug effects*; D009130:Muscle, Smooth / Q000502:physiology*; D010277:Parasympathomimetics; D011738:Pyrilamine / Q000494:pharmacology; D051381:Rats; D012970:Sodium Glutamate / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D013268:Stimulation, Chemical
D005971:Glutamates; D006584:Hexamethonium Compounds; D010277:Parasympathomimetics; D001285:Atropine; D011738:Pyrilamine; D012970:Sodium Glutamate