A search for antitumor compounds. XII. Biologic studies. Antitumor properties of 12 new 1-nitro-9alkylaminoalkylaminoacridines.
Results of the studies on antitumor activity of 12 new 1-nitro-9-alkylaminoalkylaminacridines in mice bearing Sa-180 are presented. Only one of these compounds, viz. C-846 was active repeatedly in Sa-180 test; the activity of 5 other compounds tested (C-845, C-848, C-852, C-865 and C-866) requires further elucidation by means of new tests with Sa-180. The remaining 6 compounds were inactive. Some other general effects in mice bearing Sa-180 and some aspects of the structure-activity relationship are discussed.
D000166:Acridines / Q000627:therapeutic use*; D000818:Animals; D004353:Drug Evaluation, Preclinical; D005260:Female; D006801:Humans; D008297:Male; D051379:Mice; D009368:Neoplasm Transplantation; D009564:Nitracrine / Q000031:analogs & derivatives / Q000627:therapeutic use; D012510:Sarcoma 180 / Q000188:drug therapy*; D013329:Structure-Activity Relationship
D000166:Acridines; D009564:Nitracrine