title: The conformation of fibrinogen and fibrin: an electron microscopy study.
abstract: A mica adsorption technique was used to prepare fibrinogen and early fibrin polymers for examination in the transmission electron microscope. Globular particles 10 +/- 3 nm in diameter were observed and a model for the process of aggregation of these globules into fibrous units is proposed. A comparison is made between the results obtained by the mica adsorption technique and those obtained by conventional preparation techniques involving fixation and staining.
mesh_terms: D005337:Fibrin; D005340:Fibrinogen; D006801:Humans; D008854:Microscopy, Electron / Q000379:methods*; D011487:Protein Conformation
chemical_list: D005337:Fibrin; D005340:Fibrinogen