[Effect of mineral phosphorus on mycoheptin biosynthesis].
The effect of mineral phosphorus in doses of 22.8 to 684 gamma/ml in a synthetic medium on biosynthesis of mycoheptin, an antifungal antibiotic was studied. It was found that the maximum productivity of the mycelium was at the phosphorus concentration in the medium equal to 22.8--45.6 gamma/ml and the concentration of 91.2 gamma/ml was optimal for the growth of the antibiotic-prodicing organism. The phosphorus optimal concentrations for the growth and antibiotic synthesis phases did not coincide that provided consideration of phosphorus as a limiting factor useful in control of the antibiotic biosynthesis. The content of pphosphorus in the medium 6 times higher than the optimal concentration did not inhibit the biomass accumulation and had no significant effect on the colony morphology.
D000935:Antifungal Agents / Q000096:biosynthesis*; D003470:Culture Media; D004305:Dose-Response Relationship, Drug; D010758:Phosphorus / Q000494:pharmacology*; D011090:Polyenes / Q000096:biosynthesis; D013306:Streptomycetaceae / Q000187:drug effects / Q000254:growth & development; D013997:Time Factors
D000935:Antifungal Agents; D003470:Culture Media; D011090:Polyenes; D010758:Phosphorus; C008567:mycoheptin
Vliianie mineral'nogo fosfora na biosintez mikogeptina