Plasma 17alpha-hydroxyprogesterone in spironolactone-treated hypertensives.
When measured by a specific radio-assay method which excludes drug interference, plasma 17alpha-hydroxyprogesterone levels were found to be similar in spironolactone treated hypertensives, in untreated hypertensives, and in normotensive volunteers. No in vivo evidence for a significant inhibitory effect of spironolactone on adrenal 11beta, 17alpha and 21 hydroxylases was uncovered.
D006801:Humans; D006908:Hydroxyprogesterones / Q000097:blood* / Q000302:isolation & purification; D006973:Hypertension / Q000188:drug therapy*; D013148:Spironolactone / Q000627:therapeutic use*
D006908:Hydroxyprogesterones; D013148:Spironolactone