title: Inhibitors of mitochondrial function prevent senescence in the ascomycete Podosprora anserina.
abstract: The onset of senescence, i.e. decrease of growth rate followed by cellular death, is prevented when inhibitors of mitochondrial function (ethidium-bromide, streptomycin, tiamulin) are present in the culture medium. If mycelia are transferred to a medium not containing one of these substances, senescence occurs after the usual time interval (30 d at 26 degrees C). Inhibitors of cytoplasmic protein synthesis such as emetine and cycloheximide have no effect in preventing senescence.
mesh_terms: D001203:Ascomycota / Q000187:drug effects* / Q000648:ultrastructure; D002470:Cell Survival; D003470:Culture Media; D004996:Ethidium / Q000494:pharmacology*; D008928:Mitochondria / Q000187:drug effects*; D013307:Streptomycin / Q000494:pharmacology*
chemical_list: D003470:Culture Media; D004996:Ethidium; D013307:Streptomycin