[Biologically active low-molecular fragments of fibrinogen molecule].
A peptide fraction with a specific property of interaction with D fragment was found in the fibrinogen tryptic hydrolyzate. This fraction is called a protector. In the protector presence the time of the monomer fibrin polymerization prolonged with D fragment is greatly lowered. The protector was found in the first minutes of fibrinogen degradation. It was shown for low concentration of trypsin (enzyme-substrate ratio being 1:7500). The gel filtration of a tryptic fibrinogen hydrolyzate on Sephadexes G-10, G-15, G-25 showed that the protector has a low molecular weight. It was found that a preincubation of the protector with D fragment should take place before interaction of their mixture with a fibrin monomer. The interaction of the protector with D fragment is reversible.
D005337:Fibrin / Q000378:metabolism; D005338:Fibrin Fibrinogen Degradation Products / Q000378:metabolism*; D006868:Hydrolysis; D008970:Molecular Weight; D010446:Peptide Fragments / Q000378:metabolism; D014357:Trypsin
D005338:Fibrin Fibrinogen Degradation Products; D010446:Peptide Fragments; D005337:Fibrin; D014357:Trypsin
Biologichno aktivni niz'komolekuliarni fragmenti molekuli fibrinogenu.