Effect of aminonucleoside on transport maximum of para-aminohippurate and intrarenal blood flow distribution in rats.
The present study examined intrarenal blood flow distribution and possible involvement of tubular elements in rats with aminonucleoside (AMN)-induced nephrotic syndrome. Tubular maxima of para-aminohippurate (T M PAH) were determined during mild saline expansion in control rats and in rats on days 4, 5, 6, and 14 following a single intravenous injection of AMN (10 mg/100 gm of body weight). T M PAH and glomerular filtration rates (GFR's), unchanged from controls on day 4, were equally depressed on days 5, 6, and 14; minimum values were reached on day 6. Composite linear regression analysis of controls and AMN-treated rats showed that T M PAH and GFR's were significantly correlated (r = 0.704, p less than 0.001). Microsphere studies in animals with chronic carotid catheters demonstrated a decrease in the ratio of outer to inner cortical blood flow 6 days following AMN. The data suggest that AMN produces primarily glomerular lesions and that outer cortical blood flow is more susceptible to AMN than is inner cortical blood flow.
D000618:Aminohippuric Acids / Q000378:metabolism*; D000818:Animals; D001692:Biological Transport / Q000187:drug effects; D005260:Female; D005919:Glomerular Filtration Rate / Q000187:drug effects; D007668:Kidney / Q000098:blood supply*; D007672:Kidney Cortex / Q000098:blood supply; D007684:Kidney Tubules / Q000187:drug effects / Q000378:metabolism; D008863:Microspheres; D009399:Nephrons / Q000503:physiopathology; D009404:Nephrotic Syndrome / Q000139:chemically induced / Q000378:metabolism; D011691:Puromycin / Q000031:analogs & derivatives*; D011692:Puromycin Aminonucleoside / Q000494:pharmacology*; D051381:Rats; D012039:Regional Blood Flow / Q000187:drug effects; D012965:Sodium Chloride / Q000494:pharmacology; D010130:p-Aminohippuric Acid / Q000378:metabolism*
D000618:Aminohippuric Acids; D012965:Sodium Chloride; D011691:Puromycin; D011692:Puromycin Aminonucleoside; D010130:p-Aminohippuric Acid