Porphyrin induction: equivalent effects of 5alphaH and 5betaH steroids in chick embryo liver cells.
The 5alphaH (A : B trans) and 5betaH (A : B cis) steroids are equipotent in inducing delta-aminolevulinic acid synthetase and porphyrin accumulation in chick embryo liver cells maintained in serum-free culture medium. Thus there is no specific steric requirement for porphyrin-inducing activity in steroids.
D013741:3-Oxo-5-alpha-Steroid 4-Dehydrogenase / Q000172:deficiency; D000624:5-Aminolevulinate Synthetase / Q000096:biosynthesis*; D000731:Androstanes / Q000494:pharmacology; D002478:Cells, Cultured; D003470:Culture Media; D004790:Enzyme Induction / Q000187:drug effects; D008968:Molecular Conformation; D011164:Porphyrias / Q000201:enzymology; D011166:Porphyrins / Q000096:biosynthesis*; D011280:Pregnanolone / Q000494:pharmacology; D013256:Steroids / Q000494:pharmacology*; D013329:Structure-Activity Relationship
D000731:Androstanes; D003470:Culture Media; D011166:Porphyrins; D013256:Steroids; D011280:Pregnanolone; D013741:3-Oxo-5-alpha-Steroid 4-Dehydrogenase; D000624:5-Aminolevulinate Synthetase