title: Effects of perilymphatic perfusion with neomycin on the cochlear microphonic potential in the guinea pig.
abstract: The effects of three concentrations of neomycin, administered by a method of acute perilymphatic perfusion of the guinea pig cochlea, on the cochlear microphonic potential (CM) at 4 kHz and 500 Hz are described. A concentration-dependent reduction in CM occured during the 60 minute perfusion period. Neomycin at 10-4 M did not change the CM magnitude, while at 10-3 and 102 M it caused 4 kHz (and 500 Hz) CM reductions which began within 24 (for both frequencies) minutes and 10 (and 12) minutes of drug application respectively. CM reduction proceeded at a higher rate for greater neomycin concentration. The perfusion technique, the implication of the frequency indifference, and the potential of the perfusion technique for inner ear biochemical analysis are discussed.
mesh_terms: D000200:Action Potentials / Q000187:drug effects*; D000818:Animals; D003051:Cochlea / Q000033:anatomy & histology / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D006168:Guinea Pigs; D009355:Neomycin / Q000008:administration & dosage / Q000494:pharmacology*; D010477:Perfusion; D010498:Perilymph
chemical_list: D009355:Neomycin