Wasting syndrome in neonatal mice after administration of salivary gland homogenate.
A wasting syndrome, similar to that occurring after cortisol treatment, was induced in neonatal mice by means of the daily i.p. administration of salivary gland homogenate: 24 h after a single injection of the homogenate, profuse cell necrosis was observed in the thymic cortex, 48 h later the cortex was devoid by lymphocytes. It is hypothesized that the submandibular glands of mice contain substances which are capable of inducing a cortisol-like effect.
D000818:Animals; D000831:Animals, Newborn; D006086:Graft vs Host Disease / Q000209:etiology* / Q000473:pathology; D051379:Mice; D012469:Salivary Glands / Q000502:physiology*; D013154:Spleen / Q000473:pathology; D013950:Thymus Gland / Q000473:pathology; D013997:Time Factors