title: Chlorpromazine induces population increase of synaptic vesicles in the rat hypothalamic ventromedial nucleus.
abstract: The population of synaptic vesicles per synaptic area in the hypothalamic ventromedial nucleus of rats treated with chlorpromazine (CP) for 3 days was compared with that of controls. In type I synapse, which contained 400-800 A small spherical vesicles (s-vesicles), together with 800-1200 A large spherical dense-cored vesicles (lc-vesicles), the population of s-vesicles increased 57.8% in the CP rats, In type II synapse, which contained only s-vesicles, the rate of increase among CP animals was 15.4%. Findings suggested that CP blocks the release of the vesicles from the presynaptic site or inhibits the transport function for biogenic amines through the presynaptic membrane, and type I synapse may be aminergic.
mesh_terms: D000818:Animals; D002746:Chlorpromazine / Q000494:pharmacology*; D007031:Hypothalamus / Q000187:drug effects*; D007033:Hypothalamus, Middle / Q000187:drug effects* / Q000648:ultrastructure; D008297:Male; D051381:Rats; D013572:Synaptic Vesicles / Q000187:drug effects / Q000648:ultrastructure*
chemical_list: D002746:Chlorpromazine