HLA and chronic active hepatitis (CAH).
A family study of 2 parents and 5 SD identical (HLA-A1, A3, B7, B8) siblings, one of whom has 'classic CAH' has been used to demonstrate that in this family the maternally ingerited HLA-B8 antigen is not solely serving to mark genetic predisposition to this disease. The patient's lymphocytes both responded to, and stimulated those of her 4 siblings in MLR indicating the possible involvement of an HLA-D antigen in CAH. This HLA-D antigen could have been of paternal orgin, or could have been a result of a recombination event involving an HLA-D antigen liked to the maternal HLA-A2, B12 haplotype. The lymphocytes of the four helthy siblings were mutually unresponsive in MLR.
D002908:Chronic Disease; D005260:Female; D006680:HLA Antigens / Q000032:analysis; D006505:Hepatitis / Q000235:genetics* / Q000276:immunology; D006525:Hepatitis, Viral, Human / Q000235:genetics* / Q000276:immunology; D006649:Histocompatibility Antigens / Q000032:analysis; D006720:Homozygote; D006801:Humans; D008214:Lymphocytes / Q000276:immunology; D008297:Male; D010641:Phenotype
D006680:HLA Antigens; D006649:Histocompatibility Antigens