[Cyanide insensitive respiration of Candida lipolytica yeasts].
The effect of rotenone, antimycin A, oligomycin, 2,4,-DNP, and various subtrates on the appearance of cyanide-resistant respiration of Candida lipolytica yeast was studied. Rotenone inhibited the development of cyanide-resistant respiration, but did not prevent its origination. Antimycin A and oligomycin increased the rate of the appearance of cyanide-resistant respiration. If the resting yeast culture was incubated with 2,4-DNP, glucose, or glycerol, the development of the alternative pathway of electron transport was inhibited. Such substrates as alpha-glycerophosphate, citrate, and D,L-lactate had no effect on the time of appearance of cyanide-resistant respiration. Therefore, in the stationary growth phase, an alternative, cyanide-resistant pathway of electron transport results from the inhibition of the rate of electron transport in the respiration chain.
D000968:Antimycin A / Q000494:pharmacology; D002175:Candida / Q000378:metabolism*; D003486:Cyanides / Q000494:pharmacology*; D004140:Dinitrophenols / Q000494:pharmacology; D004347:Drug Interactions; D004579:Electron Transport; D006877:Hydroxamic Acids / Q000494:pharmacology; D009840:Oligomycins / Q000494:pharmacology; D010085:Oxidative Phosphorylation / Q000187:drug effects; D010101:Oxygen Consumption / Q000187:drug effects*; D012402:Rotenone / Q000494:pharmacology
D003486:Cyanides; D004140:Dinitrophenols; D006877:Hydroxamic Acids; D009840:Oligomycins; D012402:Rotenone; D000968:Antimycin A
Izuchenie tsianidnechuvstvitel'nogo dykhaniia drozhzeĭ Candida lipopytica.