Eosinophilic fasciitis.
A detailed evaluation of the clinical and histologic manifestations of eosinophilic fasciitis is described in a 22-year-old woman. Scleroderma-like skin involvement is associated with eosinophilia and hypergammaglobulinemia. Visceral and serologic manifestations of a generalized scleroderma are lacking. Results of a biopsy showed severe thickening of the deep fascia accompanied by an infiltration of lymphocytes and plasma cells. This syndrome must be differentiated from generalized scleroderma because eosinophilic fascitis has a benign course and may benefit from systemic corticosteroid therapy.
D000328:Adult; D003937:Diagnosis, Differential; D004802:Eosinophilia / Q000473:pathology*; D005205:Fascia / Q000473:pathology*; D005260:Female; D006801:Humans; D006942:Hypergammaglobulinemia / Q000473:pathology*; D008214:Lymphocytes / Q000473:pathology; D010950:Plasma Cells / Q000473:pathology; D012595:Scleroderma, Systemic / Q000473:pathology*; D013577:Syndrome