title: Extraocular muscle fibers: ultrastructural identification of iontophoretically labeled fibers contracting in response to succinylcholine.
abstract: Cat extraocular muscle fibers (from the superior rectus or inferior oblique) were penetrated in vivo with Procion red-filled glass microelectrodes. When stable penetrations were obtained, succinylcholine (Sch), 8 to 20 microng, was injected into the femoral vein. In some fibers, a depolarization-repolarization response was obtained with the same time course (2 min.) as the total muscle contraction. The depolarizing fibers were labeled iontophoretically. The ultrastructural characteristics of five depolarizing fibers and three control (nondepolarizing) fibers were then studied. The fibers that did not depolarize to Sch had the characteristics of singly innervated cells, whereas those sensitive to Sch had morphological characteristics of multi-innervated fibers.
mesh_terms: D000818:Animals; D002415:Cats; D007478:Iontophoresis; D008564:Membrane Potentials / Q000187:drug effects; D009119:Muscle Contraction / Q000187:drug effects*; D009801:Oculomotor Muscles / Q000187:drug effects / Q000294:innervation / Q000648:ultrastructure*; D013390:Succinylcholine / Q000008:administration & dosage / Q000494:pharmacology*
chemical_list: D013390:Succinylcholine