Induction of mixed function oxidases on oral administration of dieldrin.
The administration of dieldrin (30 mg/kg body weight) caused an increase in the liver weight of rats. The metabolism of aflatoxins B1 and G1 by the microsomes obtained from the liver of dieldrin-treated animals was enhanced significantly as compared to the controls showing that dieldrin increased the activity of mixed function hydroxylases. Dieldrin caused an increase in the activity of liver microsomal NADPH oxidase and a decrease in the lipid peroxidation. Dieldrin brought about an increase in the phosphatidylcholine content of rat liver.
D000284:Administration, Oral; D000348:Aflatoxins / Q000378:metabolism*; D000818:Animals; D001835:Body Weight; D004026:Dieldrin / Q000008:administration & dosage / Q000494:pharmacology*; D004790:Enzyme Induction; D008297:Male; D008862:Microsomes, Liver / Q000187:drug effects / Q000201:enzymology / Q000378:metabolism*; D006899:Mixed Function Oxygenases / Q000096:biosynthesis*; D010088:Oxidoreductases / Q000096:biosynthesis*; D010743:Phospholipids / Q000378:metabolism; D051381:Rats
D000348:Aflatoxins; D010743:Phospholipids; D006899:Mixed Function Oxygenases; D010088:Oxidoreductases; D004026:Dieldrin