Fenfluramine long-term administration and brain serotonin.
Long-term administration of fenfluarmine induced a decrease of brain 5-HT to the same extent as did an acute dose. 48 h after drug withdrawal, the brain serotonin level returned to the control value. The present study provides evidence to suggest that a degenerative lesion of 5-HT neurons is not involved in fenfluramine activity.
D000818:Animals; D001923:Brain Chemistry / Q000187:drug effects*; D005277:Fenfluramine / Q000008:administration & dosage / Q000494:pharmacology*; D008297:Male; D051381:Rats; D012701:Serotonin / Q000032:analysis*; D013997:Time Factors
D005277:Fenfluramine; D012701:Serotonin