Localization of HLA on the short arm of chromosome 6.
A detailed marker gene study in a large Dutch kindred segregating for a reciprocal translocation between the chromosomes 6 and 20, t(6;20) (p21; p13), revealed a close linkage between the HLA genes and the breakpoint on the short arm of 6. During this study an apparent peak lod score of 2.9 was obtained at a recombination value of 0.05 for a linkage between HLA and the breakpoint, indicating that the chromosomal region, carrying the HLA genes, is situated near the breakpoint in band 6p21 close to the transition to 6p22.
D000015:Abnormalities, Multiple / Q000235:genetics; D002874:Chromosome Mapping; D002903:Chromosomes, Human, 19-20; D002906:Chromosomes, Human, 6-12 and X; D005260:Female; D008040:Genetic Linkage; D006680:HLA Antigens; D006649:Histocompatibility Antigens; D006801:Humans; D007223:Infant; D008297:Male; D009426:Netherlands; D010375:Pedigree; D011995:Recombination, Genetic; D014178:Translocation, Genetic
D006680:HLA Antigens; D006649:Histocompatibility Antigens