Ultrastructural features of psoralen plus black light induced successive changes in psoriatic cell.
Based on an ultramicroscopic investigation of the psoralen plus black light-induced photodynamic reaction in the psoriatic cell, there is evidence that the primary reaction takes place in the nuclei, which possess abundant nucleic acid. This initial reaction is manifested by a large vacuole situated in the nucleus. As the vacuole gradually enlarges, the nucleus becomes an annex to the vacuole, while the cytoplasm of the cell succumbs to the necrobiotic process.
D002467:Cell Nucleus / Q000187:drug effects / Q000528:radiation effects / Q000648:ultrastructure; D003374:Coumarins / Q000627:therapeutic use*; D003593:Cytoplasm / Q000187:drug effects / Q000528:radiation effects / Q000648:ultrastructure; D003896:Desmosomes / Q000187:drug effects / Q000528:radiation effects / Q000648:ultrastructure; D005363:Ficusin / Q000627:therapeutic use*; D006801:Humans; D011565:Psoriasis / Q000188:drug therapy* / Q000532:radiotherapy*; D014617:Vacuoles / Q000187:drug effects / Q000528:radiation effects / Q000648:ultrastructure
D003374:Coumarins; D005363:Ficusin