Hepatic mixed-function oxidase activity in mice treated with methylated benzenes and methylated naphthalenes.
Eight methylated benzene and five methylated naphthalene compounds were injected ip into adult male mice daily for 3 days. On the fourth day livers from control and treated mice were compared with regard to weight, microsomal N- and O-demethylase activity, and various spectral characteristics of microsomal cytochrome P-450. Three methylated benzenes and one methylated naphthalene produced significant increases in liver weight/body weight ratios, O-demethylation of p-nitroanisole, N-demethylation of aminopyrene, or a combination of these.
D000818:Animals; D001555:Benzene Derivatives / Q000494:pharmacology*; D008099:Liver / Q000187:drug effects / Q000201:enzymology*; D008297:Male; D008745:Methylation; D051379:Mice; D008815:Mice, Inbred Strains; D006899:Mixed Function Oxygenases / Q000378:metabolism*; D009281:Naphthalenes / Q000494:pharmacology*; D010088:Oxidoreductases / Q000378:metabolism*
D001555:Benzene Derivatives; D009281:Naphthalenes; D006899:Mixed Function Oxygenases; D010088:Oxidoreductases