Lactoferrin in synovial fluid.
The synovial lactoferrin (LF) concentrations of 59 patients with active rheumatoid arthritis were determined. The median value of LF was 4.64+/-3.59 mg/100 ml, but in degenerative arthropathy the levels of the metal-protein were much lower and often not titratable. These variations in the LF concentration explain the low blood-iron levels in inflammatory states, even when the concentration of the metal-protein is not statistically correlated in inflammatory tests, IgG, complement fractions (of the normal or alternate pathway), or variations of other protein fractions of leucocyte origin.
D001172:Arthritis, Rheumatoid / Q000175:diagnosis*; D006801:Humans; D007718:Knee Injuries / Q000175:diagnosis; D007781:Lactoferrin / Q000032:analysis* / Q000097:blood; D007782:Lactoglobulins / Q000032:analysis*; D008180:Lupus Erythematosus, Systemic / Q000175:diagnosis; D013180:Sprains and Strains / Q000175:diagnosis; D013582:Synovial Fluid / Q000032:analysis*
D007782:Lactoglobulins; D007781:Lactoferrin