Calcium and the contractile response to prostaglandin in the smooth muscle of guinea-pig stomach.
In the longitudinal smooth muscle of guinea-pig stomach, verapamil (10(-5) M) which showed marked suppression of high K-induced contractures, did not suppress the contractile response to PGE1 (1.5 X 10(-9) to 10(-6) M) markedly. These results suggest that the contractile mechanism of PGE1 in guinea-pig stomach may mainly depend on a release of bound Ca in the cell and partly depend on a Ca influx from the extracellular origin.
D000109:Acetylcholine / Q000494:pharmacology; D000818:Animals; D002118:Calcium / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D006168:Guinea Pigs; D007082:Ileum / Q000187:drug effects / Q000502:physiology; D009119:Muscle Contraction / Q000187:drug effects*; D009130:Muscle, Smooth / Q000187:drug effects / Q000502:physiology*; D011188:Potassium / Q000494:pharmacology; D011458:Prostaglandins E / Q000494:pharmacology; D014700:Verapamil / Q000494:pharmacology
D011458:Prostaglandins E; D014700:Verapamil; D000109:Acetylcholine; D011188:Potassium; D002118:Calcium