[Mechanism of the regulatory influence of an effector cell on noradrenaline-H3 uptake by an adrenergic neuron].
In isolated organs of the white rat, activation of neuronal absorption of noradrenaline-H3 under action of alpha-adrenoblocking agent phentolamine (1-10(-6) M) was due to release of a humoral factor from the effector cell and its effect on the adrenergic neuron. Under influence of activating agent for alpha-adrenoreceptors mesatone (1-10(-5) M), formation and release of humoral factor inhibiting the neuronal absorption of noradrenaline-H3, occurrs. Formation of the humoral factors altering the intensity of amine absorption is associated with activation of the protein synthesis in effector cell and occurs on alteration of functional state (excitation and blockade) of postsynaptic adrenoreceptors. A possible way for the reverse transsynaptic control of neuronal absorption of noradrenaline via adrenoreceptors of effector cell, and the role of this regulatory mechanism in activity of adrenergic system, are discussed.
D000818:Animals; D003513:Cycloheximide / Q000494:pharmacology; D006321:Heart / Q000294:innervation*; D066298:In Vitro Techniques; D008297:Male; D009206:Myocardium / Q000378:metabolism; D009638:Norepinephrine / Q000378:metabolism*; D010646:Phentolamine / Q000494:pharmacology; D010656:Phenylephrine / Q000494:pharmacology; D051381:Rats; D011941:Receptors, Adrenergic; D014649:Vas Deferens / Q000294:innervation* / Q000378:metabolism
D011941:Receptors, Adrenergic; D010656:Phenylephrine; D003513:Cycloheximide; D009638:Norepinephrine; D010646:Phentolamine
Mekhanizm reguliatornogo vliianiia éffektornĭ kletki na zakhvat noradrenalina-H3 adrenergicheskim neĭronam.