Semisynthetic beta-Lactam antibiotics. II. Penicillins from alpha-hydrazinoarylacetic acids.
A number of penicillins (2) have been synthesized from the alpha-hydrazinoarylacetic acids (4) via the activated chloride hydrochlorides (5) or via the mixed anhydride of the corresponding N2-benzyloxycarbonyl derivatives (6). The penicillins, 2b, e, j, show good activity against gram-positive and gram-negative bacteria and enhanced penicillinase resistance in comparison with ampicillin.
D000085:Acetates; D001419:Bacteria / Q000187:drug effects; D055598:Chemical Phenomena; D002621:Chemistry; D004355:Drug Stability; D006834:Hydrazines; D008826:Microbial Sensitivity Tests; D010405:Penicillinase / Q000378:metabolism; D010406:Penicillins / Q000032:analysis / Q000138:chemical synthesis* / Q000494:pharmacology
D000085:Acetates; D006834:Hydrazines; D010406:Penicillins; D010405:Penicillinase