The roles of ventilation and perfusion in lung metabolism.
The lung, like other viable organs, requires the adequate supply of oxygen and metabolic substrates for its functional and structural integrity. Therefore, we studied the metabolic and ultrastructural consequences in the canine lung following bronchial and/or pulmonary arterial occlusions. The results indicate that the lung can maintain its bioenergetic levels for 5 hours with either the ventilation or perfusion alone. Ultrastructural changes appear to precede metabolic alterations measured. When both the ventilation and perfusion were interrupted, rapid biochemical and structural deteriorations occurred, whereas the combinations of alveolar obliteration and hypoxemia, induced with low F102, produced intermediate damage. The implications of these findings on the pathogenesis and evolution of acute respiratory distress syndrome, on the lung preservation for transplantation, and on the rationale for membrane oxygenator support are discussed.
D000244:Adenosine Diphosphate / Q000378:metabolism; D000255:Adenosine Triphosphate / Q000378:metabolism; D000402:Airway Obstruction / Q000378:metabolism; D000818:Animals; D001157:Arterial Occlusive Diseases / Q000378:metabolism; D001784:Blood Gas Analysis; D001786:Blood Glucose / Q000378:metabolism; D004285:Dogs; D006003:Glycogen / Q000378:metabolism; D000860:Hypoxia / Q000378:metabolism; D007773:Lactates / Q000378:metabolism; D008168:Lung / Q000378:metabolism* / Q000648:ultrastructure; D011183:Postoperative Complications / Q000378:metabolism*; D011651:Pulmonary Artery; D011654:Pulmonary Edema / Q000473:pathology; D012128:Respiratory Distress Syndrome / Q000378:metabolism* / Q000473:pathology; D014692:Ventilation-Perfusion Ratio
D001786:Blood Glucose; D007773:Lactates; D000244:Adenosine Diphosphate; D000255:Adenosine Triphosphate; D006003:Glycogen