title: [Biosynthesis of insulin. The Ferdinand-Bertram-Award lecture (author's transl)].
abstract: EEG recordings were done 1-3 months before and up to 5 years after shunt operations in 20 men and 7 women (aged 16 to 69 years) with liver cirrhosis, most of them of alcoholic aetiology, and with oesophageal bleeding. The EEG diagnosed encephalopathies before there were any clinical suspicions. Pre-operatively half of the patients (14) had EEG changes indicating encephalopathy. In only four patients who before operation had a normal EEG were there post-operative EEG changes indicating encephalopathy. In the other nine patients the EEG was normal before and after shunt operation. The abnormal EEGs which occurred post-operatively or got worse generally returned to pre-operative levels within 3-4 weeks. These studies indicate that in patients with pre-operative encephalopathy there is no improvement in the EEG after shunt operation. On the other hand, if pre-operatively there are no significant cerebral abnormalities, post-operative changes of encephalopathy are rare (14.8%).
mesh_terms: D000595:Amino Acid Sequence; D006801:Humans; D007328:Insulin / Q000096:biosynthesis* / Q000378:metabolism; D000078790:Insulin Secretion; D011384:Proinsulin / Q000096:biosynthesis
chemical_list: D007328:Insulin; D011384:Proinsulin
vernacular_title: Biosynthese von Insulin