[Effect of monoamines, heat shock and other factors on the binding of several neuropharmacologic preparations by sea urchin embryos].
Early embryos of the sea urchins Arbacia lixula and Paracentrotus lividus being subjected to an osmotic or heat shock (10 min at 70 degrees C or higher) do not longer bind cytotoxic pharmaca and do not affect the sensitivity of normal indicator embryos to these drugs. After exposure for 10 min at 40 degrees C, the binding of neuropharmaca by embryos is not affected, although their ability to protect indicator embryos from the action of these neuropharmaca is inhibited 4--5 times. Serotonin and adrenaline inhibit the binding of neuropharmaca by 10--20%, while meterazine, noveryl and an amphetamine derivative--IEM-567--inhibit it by 50--60%. Antimycin A, rotenone and mercuric chloride do not affect the binding of neuropharmaca by sea urchin embryos.
D000588:Amines / Q000494:pharmacology*; D000818:Animals; D001665:Binding Sites; D004625:Embryo, Nonmammalian / Q000378:metabolism*; D006358:Hot Temperature; D009997:Osmotic Pressure; D011619:Psychotropic Drugs / Q000378:metabolism*; D012617:Sea Urchins
D000588:Amines; D011619:Psychotropic Drugs
Vliianie monoaminov, teplovogo shoka i drugikh faktorov na sviazyvanie nekotorykh meĭrofarmakologicheskikh preparatov émbrionami morskikh ezhei