Influence of some sympathomimetic amines on the experimental gastric ulcers in rats.
In reserpine-induced ulcers in rats, the centrally acting sympathomimetic ámines (amphetamine, mephentermine and ephedrine) produced a significant protection. Only amphetamine had a beneficial effect in restraint ulcers. Tyramine, a preponderant peripherally acting sympathominetic amine, was inefficient in both experimental models. It is suggested that the protective activity is due to the influence of these amines on the adrenergic structures, mainly at central level.
D000661:Amphetamine / Q000627:therapeutic use; D000818:Animals; D004809:Ephedrine / Q000627:therapeutic use; D008297:Male; D008616:Mephentermine / Q000627:therapeutic use; D051381:Rats; D011941:Receptors, Adrenergic / Q000187:drug effects*; D012110:Reserpine; D013276:Stomach Ulcer / Q000139:chemically induced / Q000517:prevention & control*; D013566:Sympathomimetics / Q000627:therapeutic use*; D014439:Tyramine / Q000627:therapeutic use
D011941:Receptors, Adrenergic; D013566:Sympathomimetics; D012110:Reserpine; D000661:Amphetamine; D004809:Ephedrine; D008616:Mephentermine; D014439:Tyramine