HLA-B5 associated with duodenal ulcer.
In a search for further genetic factors contributing to ulcer disease we undertook a study of the frequency of HLA antigens in patients with duodenal ulcer. Seventy-seven male patients (of two races) were typed for the HLA-A and-B loci. Thirteen of the 54 (24%) white males were found to have antigen B5 compared to 10% of controls. These results have a P value of 0.0016 which remains significant even when multiplied by the number of antigens tested (28). These results demonstrate a significant association between duodenal ulcer and HLA antigen B5 in white males, with a relative risk of 2.9, greater than that associated with the combination of blood group O and nonsecretor status.
D000017:ABO Blood-Group System; D004381:Duodenal Ulcer / Q000235:genetics* / Q000276:immunology; D005787:Gene Frequency; D006680:HLA Antigens; D006649:Histocompatibility Antigens; D006801:Humans; D008297:Male; D012306:Risk
D000017:ABO Blood-Group System; D006680:HLA Antigens; D006649:Histocompatibility Antigens