Suppression of the primary immune response by chemical sympathectomy.
The effects of general sympathectomy with 6-hydroxydopamine (6-OHDA) on antibody production to sheep red cells (SRBC) were studied in mice. Intraperitoneal administration of 6-OHDA in a dose of 1 to 300mg/kg resulted in a significant decrease in hemagglutinin titer and number of direct plaque-forming cells which were observed only in the early period of the primary immune response. Following treatment with 6-OHDA 10mg/kg i.p., the noradrenaline content in murine spleen was significantly reduced from 63 to 42% of control value between 2 and 10 days after injection indicating that chemical sympathectomy suppresses the primary immune response.
D000818:Animals; D000917:Antibody Formation / Q000187:drug effects*; D003864:Depression, Chemical; D004912:Erythrocytes / Q000276:immunology; D005260:Female; D006892:Hydroxydopamines / Q000494:pharmacology*; D007166:Immunosuppressive Agents; D008297:Male; D051379:Mice; D008809:Mice, Inbred C3H; D009638:Norepinephrine / Q000378:metabolism; D012756:Sheep / Q000276:immunology; D013154:Spleen / Q000187:drug effects / Q000378:metabolism; D013564:Sympathetic Nervous System / Q000187:drug effects / Q000502:physiology*; D013997:Time Factors
D006892:Hydroxydopamines; D007166:Immunosuppressive Agents; D009638:Norepinephrine