[Reduction of myocardial ischemia by betablocker (Pindolol) in patients with acute infarction (author's transl)].
Seven patients with acute anterior myocardial infarction were treated with a betablocker (Pindolol 0.1-0.2 mg i.v.). The goal of the study was to determine the course of the ischemic ST elevation by means of precordial Ecg mapping (sigma-ST). Within 20 min a reduction of of sigma-ST of 23% p less than 0.05 and of the heart rate of 10% p less than 0.05 was noticed. The mean arterial pressure remained constant. In one case the heart rate rose, so did the sigma-ST. -Beside heart rate reduction a competitive effect of the betablocker against myocardial catecholamines in the ischemic area may lead to these results.
D000208:Acute Disease; D000328:Adult; D000368:Aged; D001794:Blood Pressure / Q000187:drug effects; D003326:Coronary Circulation / Q000187:drug effects*; D004562:Electrocardiography; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D007511:Ischemia; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000175:diagnosis / Q000188:drug therapy*; D010869:Pindolol / Q000494:pharmacology* / Q000627:therapeutic use
D010869:Pindolol
Reduktion der myokardialen Ischämie beim akuten Infarkt durch Betablocker (Pindolol).