[Transformation of mitochondrial monoaminoxidases types A and B].
Chlorgyline, a selective monoamine oxidase (MAO) of the A type inhibitor, contrary to deprenil--MAO of the B type inhibitor, prevented the appearance in the rat liver mitochondrial membrane fragments incubated under aerobic conditions of qualitatively new properties to deaminate histamine or AMP. Apparently the MAO of A type but not of B type underwent a qualitative alteration (transformation) of catalytic properties under conditions favourable for partial oxidation of SH-groups.
D000818:Animals; D002384:Catalysis; D055598:Chemical Phenomena; D002621:Chemistry; D003010:Clorgyline / Q000494:pharmacology*; D066298:In Vitro Techniques; D008930:Mitochondria, Liver / Q000201:enzymology*; D008996:Monoamine Oxidase Inhibitors / Q000494:pharmacology*; D010627:Phenethylamines / Q000494:pharmacology*; D011437:Propylamines / Q000494:pharmacology*; D051381:Rats
D008996:Monoamine Oxidase Inhibitors; D010627:Phenethylamines; D011437:Propylamines; D003010:Clorgyline
O transformatsii mitokhondrial'nykh monoaminoksidaz tipov A i B.