[Effect of poly-4-vinylpyridine on the quantity of colony-forming cells in the bone marrow and spleen of mice].
Administration of poly-4-vinylpyridine to mice in the maximal tolerance dose doubled the colony-forming units (CFU) and decreased the cell count by 22% in the bone marrow. The increase of CFU number takes place from 2 to 7 days. The cell count in the bone marrow began to decreased 2 hours after the administration of the polymer and remained below the initial level for 5 days; however it began to return to the normal from the second day, reaching the normal figures by the 7th day. In the spleen the CFU rose 9-fold, with a simultaneous development of splenomegaly on account of increased cell count.
D000818:Animals; D001853:Bone Marrow / Q000187:drug effects*; D001854:Bone Marrow Cells; D002455:Cell Division / Q000187:drug effects; D002999:Clone Cells; D006824:Hybridization, Genetic; D051379:Mice; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D011108:Polymers / Q000494:pharmacology; D011725:Pyridines / Q000494:pharmacology*; D013154:Spleen / Q000187:drug effects*; D014753:Vinyl Compounds / Q000494:pharmacology*
D011108:Polymers; D011725:Pyridines; D014753:Vinyl Compounds
Vliianie poli-4-vinilpiridina na chislo koloneobrazuiushchikh kletok v kostnom mozge i selezenke mysheĭ