Stimulation of renin release by prostaglandin E2.
The effect of different doses of prostaglandin E2 on renin secretion in isolated perfused rat kidney has been studied. The infusion of 5 ng/ml of prostaglandin E2 produced a significant rise on renin secretion compared with control group. A dosage increase of prostaglandin E2 (10 and 50 ng/ml) produced an increase in the released renin. From this a correlation between doses and responses can be obtained. The perfusion pressure was slightly--but significantly--modified with the highest dose of prostaglandin (50 ng/ml). The possible pathways of action are dicussed.
D000818:Animals; D004285:Dogs; D007668:Kidney / Q000187:drug effects* / Q000502:physiology; D011458:Prostaglandins E / Q000494:pharmacology*; D051381:Rats; D012083:Renin / Q000378:metabolism*; D013268:Stimulation, Chemical
D011458:Prostaglandins E; D012083:Renin