Pharmacokinetics of vindesine and vincristine in humans.
Vindesine, a new Phase 1 Vinca alkaloid congener, exhibited serum pharmacokinetic behavior in humans compatible with a three-compartment, open mammilary model. The kinetic parameters included: t1/2 alpha=3.24+/-1.14 min, t1/2beta=99.0+/-44.5 min, t1/2gamma=1213+/-493 min, Vc (Valpha)=4.81+/-2.12 liters, Vbeta=58.2+/-50.5 liters, Vgamma=598+/-294 liters. Vincristine, studied only for the first 4 hr, behaved like a two-compartment system, with values of t1/2 alpha=3.37+/-0.72 min, t1/2beta=155+/-18 min, Valpha=4.53+/-0.49 liters, and Vbeta=57.3+/-21.1 liters. Urine excretion data demonstrated that most drug elimination occurred within the first 24 hr and amounted to 13.2+/-5.9% for vindesine and 9.5+/-5.1% for vincristine.
D006801:Humans; D007700:Kinetics; D008657:Metabolic Clearance Rate; D011863:Radioimmunoassay; D014747:Vinblastine / Q000031:analogs & derivatives* / Q000097:blood; D014748:Vinca Alkaloids / Q000378:metabolism / Q000652:urine; D014750:Vincristine / Q000097:blood* / Q000378:metabolism / Q000652:urine
D014748:Vinca Alkaloids; D014750:Vincristine; D014747:Vinblastine