Macrolide antibiotics M-4365 produced by Micromonospora. II. Chemical structures.
By physiochemical analyses and chemical procedures, the structures of a series of basic 16-membered macrolide antibiotics, M-4365, A1, A2, A3, G1, G2 and G3 were elucidated, and it was found that M-4365 A1, G1 and G2 were novel, while M-4365 A2, A3 and G3 were identical with rosamicin, juvenimicins A4 and B1, respectively.
D000617:Aminoglycosides; D000900:Anti-Bacterial Agents / Q000096:biosynthesis; D055598:Chemical Phenomena; D002621:Chemistry; D007783:Lactones; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D008847:Micromonospora / Q000378:metabolism
D000617:Aminoglycosides; D000900:Anti-Bacterial Agents; D007783:Lactones