Methiothepin and a 5-HT pathway to rat substantia nigra.
Methiothepin reduced both median-raphe evoked and exogenous 5-HT depression of single substantia nigra neurones. While this is compatible with a serotonin releasing pathway, additional interactions of methiothepin with exogenous dopamine suggest the need for further pharmacological confirmation.
D000109:Acetylcholine / Q000494:pharmacology; D000818:Animals; D003988:Dibenzothiepins / Q000494:pharmacology*; D018492:Dopamine Antagonists; D004558:Electric Stimulation; D008636:Mesencephalon / Q000502:physiology*; D008719:Methiothepin / Q000494:pharmacology*; D009433:Neural Inhibition / Q000187:drug effects*; D009434:Neural Pathways / Q000502:physiology; D051381:Rats; D012154:Reticular Formation / Q000502:physiology*; D012701:Serotonin / Q000494:pharmacology*; D012702:Serotonin Antagonists; D013378:Substantia Nigra / Q000187:drug effects*; D005680:gamma-Aminobutyric Acid / Q000494:pharmacology
D003988:Dibenzothiepins; D018492:Dopamine Antagonists; D012702:Serotonin Antagonists; D012701:Serotonin; D008719:Methiothepin; D005680:gamma-Aminobutyric Acid; D000109:Acetylcholine