Diabetes-induced alteration in subcellular distribution of poly(A)-rich RNA from skeletal muscle.
Skeletal muscle ribosome preparations from diabetic rats have lower polysome content than those from normal animals. The ratio of poly(A) containing RNA between polysomes and postribosomal supernatant has been measured both in normal and diabetic rats. The results suggest that in diabetic animals there is a greater proportion of free poly(A) containing RNA, in postribosomal supernatant.
D000818:Animals; D001483:Base Sequence; D002458:Cell Fractionation; D003921:Diabetes Mellitus, Experimental / Q000378:metabolism*; D009132:Muscles / Q000378:metabolism*; D009693:Nucleic Acid Hybridization; D011061:Poly A / Q000032:analysis / Q000378:metabolism*; D011132:Polyribosomes / Q000378:metabolism / Q000648:ultrastructure; D012335:RNA, Ribosomal / Q000378:metabolism*; D051381:Rats; D012270:Ribosomes / Q000378:metabolism / Q000648:ultrastructure; D013347:Subcellular Fractions / Q000378:metabolism
D012335:RNA, Ribosomal; D011061:Poly A