[Effect of the preliminary action of angiotensin on the sensitivity of the adrenal cortex of dogs to this peptide].
Experiments on dogs demonstrated that an increase of aldosterone secretion depended not only on the angiotensin II level in the blood, but also on the character of the changes in the peptide concentration: reaction of the glomerular zone of the adrenal cortex to this octapeptide increased after a preliminary angiotensin stimulation of the adrenal glands. The effect revealed was independent of the sum total dose of the preparation administered and was not accompanied by any increase in the glucocorticosteroid level in the plasma. This effect permitted the renin-aldosterone system to change under definite conditions to increased functional level without any marked rise of renin secretion and angiotensin II formation.
D015062:11-Hydroxycorticosteroids / Q000097:blood; D000302:Adrenal Cortex / Q000187:drug effects / Q000378:metabolism*; D000311:Adrenal Glands / Q000378:metabolism*; D000450:Aldosterone / Q000378:metabolism; D000804:Angiotensin II / Q000008:administration & dosage / Q000494:pharmacology*; D000818:Animals; D004285:Dogs; D007263:Infusions, Parenteral; D008297:Male; D013268:Stimulation, Chemical
D015062:11-Hydroxycorticosteroids; D000804:Angiotensin II; D000450:Aldosterone
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