The effects of zinc on the morphology of sickle red blood cell ghosts as observed by scanning electron microscopy.
The objective of these studies is to define the role of zinc in RBC ghost morphology specifically in comparison to the echinocytogenic effects of calcium. Erythrocyte ghosts were prepared from patients with sickle cell anemia, treated with zinc and/or calcium and the resulting cell morphology studied by scanning electron microscopy. Our results showed that zinc consistently and significantly antagonized the echinocytogenic effect of calcium. A simple log linear statistical model was used to evaluate the data and supported this conclusion. We discuss the potential significance of these findings to the effect of zinc treatment on patients with sickle cell anemia.
D000284:Administration, Oral; D000755:Anemia, Sickle Cell / Q000097:blood*; D002118:Calcium / Q000008:administration & dosage / Q000037:antagonists & inhibitors / Q000378:metabolism; D004910:Erythrocyte Membrane / Q000187:drug effects / Q000648:ultrastructure*; D004912:Erythrocytes / Q000378:metabolism / Q000648:ultrastructure*; D006801:Humans; D015032:Zinc / Q000008:administration & dosage / Q000378:metabolism / Q000494:pharmacology*
D015032:Zinc; D002118:Calcium