The effect of E type prostaglandins on the proliferation of haemopoietic stem cells in vivo.
The ability of protaglandins E1 and E2 to stimulate the proliferation of haemopoietic stem cells (CFUS) was studied in vivo. PGE2, in a dose range of 10(-4) to 10(-1) microgram/g body weight and PGE1 in a dose range of 10(-5) to 10(-1) microgram/g body weight, produced a rapid cycling wave of CFUS. The increase in the number of CFUS in S phase was not followed by a rise in the femoral CFUS content, and except for a transient increase in femoral CFUC level, no increase in differentiation was found either. Therefore, it is proposed that haemopoiesis after PG-induced CFU stimulation is ineffective. PGE2 did not stimulate regeneration of CFUS in a perturbed state (after sublethal irradiation). All these findings support  the idea that PGEs might represent potent stimulators of the haemopoietic stem cells acting in physiological doses. However, if acting concurrently with physiological control systems PGs lead to ineffective haemopoiesis (under normal conditions) or do not exert any measurable effect (after sublethal irradiation).
D000818:Animals; D002455:Cell Division / Q000187:drug effects; D002999:Clone Cells / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D006410:Hematopoiesis / Q000187:drug effects*; D006412:Hematopoietic Stem Cells / Q000166:cytology / Q000187:drug effects*; D007700:Kinetics; D051379:Mice; D011458:Prostaglandins E / Q000494:pharmacology*
D011458:Prostaglandins E