[Combined action of benzylpenicillin and bile acids on staphylococci].
The antimicrobial effect of benzylpenicillin in combination with bile acids on staphylococci was studied. It was shown that bile acids increased the bacteriostatic and bactericidal effects of the antibiotic. The highest potentiating effect was found with combination of benzylpenicillin and desoxycholic and choleic acids. When resistant strains of staphylococci were exposed to the combination of the bile acids and benzylpenicillin they became highly sensitive to antibiotic.
D001647:Bile Acids and Salts / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D004357:Drug Synergism; D008826:Microbial Sensitivity Tests; D010400:Penicillin G / Q000494:pharmacology*; D010403:Penicillin Resistance / Q000187:drug effects; D013210:Staphylococcus / Q000187:drug effects*
D001647:Bile Acids and Salts; D010400:Penicillin G
Sochetannoe deĭstvie benzilpenitsillina i zhelchnykh kislot na stafilokokki.