Management of severe childhood hypertension with minoxidil: a controlled clinical study.
The therapeutic efficacy of four antihypertensive regimens (minoxidil, propranolol, and hydrochlorothiazide; propranolol and hydrochlorothiazide; methyldopa and hydroch-orothiazide; and hydrochlorothiazide alone) was evaluated in one child with systolic hypertension and in eight children with systolic and diastolic hypertension. The mean blood pressure of 148/98+/-8/4 mm Hg observed during the hydrochlorothiazide control period fell to 142/88+/-8/4 mm Hg following methyldopa and hydrochlorothiazide, 141/85+/-6/2 mm Hg following propranolol and hydrochlorothiazide, and 128/74+/-4/2 mm Hg following minoxidil, propranolol, and hydrochlorothiazide. The only side effect directly associated with administration of minoxidil was hypertrichosis. The effectiveness of minoxidil in the present study suggests that this drug offers an important adjunct to current antihypertensive therapy in children.
D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D004338:Drug Combinations; D004341:Drug Evaluation; D006801:Humans; D006852:Hydrochlorothiazide / Q000627:therapeutic use; D006973:Hypertension / Q000188:drug therapy*; D007223:Infant; D007231:Infant, Newborn; D008750:Methyldopa / Q000627:therapeutic use; D008914:Minoxidil / Q000627:therapeutic use*; D011433:Propranolol / Q000627:therapeutic use; D011743:Pyrimidines / Q000627:therapeutic use*
D004338:Drug Combinations; D011743:Pyrimidines; D006852:Hydrochlorothiazide; D008750:Methyldopa; D008914:Minoxidil; D011433:Propranolol