Renin-angiotensin system and aldosterone secretion during aortic constriction in the rat.
Suprarenal aortic constriction sufficient to reduce renal perfusion pressure by approximately 50% increased aldosterone secretion in anesthetized rats pretreated with dexamethasone. Bilateral nephrectomy under the same experimental conditions blocked the aldosterone response. Additionally, [1-sarcosine, 8-alanine]angiotensin II blocked the response in aldosterone secretion to aortic constriction in dexamethasone-treated rats. Finally, in rats hypophysectomized to exclude the influence of ACTH, the aldosterone response to aortic constriction was blocked by [1-sarcosine, 8-alanine]angiotensin II. The results indicate that angiotensin II increased aldosterone secretion during aortic constriction in the rat. These observations, along with those reported previously in sodium-depleted rats, point to an important overall role for the renin-angiotensin system in the control of aldosterone secretion in the rat.
D000311:Adrenal Glands / Q000098:blood supply; D000450:Aldosterone / Q000378:metabolism*; D000804:Angiotensin II / Q000031:analogs & derivatives*; D000818:Animals; D001012:Aorta, Abdominal; D001794:Blood Pressure; D003345:Corticosterone / Q000378:metabolism; D003907:Dexamethasone / Q000494:pharmacology; D007016:Hypophysectomy; D007668:Kidney / Q000098:blood supply*; D008297:Male; D009392:Nephrectomy; D011188:Potassium / Q000097:blood; D051381:Rats; D012039:Regional Blood Flow / Q000187:drug effects; D012504:Saralasin / Q000494:pharmacology*; D012964:Sodium / Q000097:blood
D000804:Angiotensin II; D000450:Aldosterone; D003907:Dexamethasone; D012964:Sodium; D012504:Saralasin; D011188:Potassium; D003345:Corticosterone