[Results of a study of the pharmacokinetics of actinomycete RNAase in the bodies of white rats].
The pharmacokinetics of RNA-ase from Act. rimosus was studied on albino rats. The enzyme activity in the biological tests was determined spectrophotometrically by the increase of the acid-soluble products formed as a result of RNA-ase effect on RNA. The preparation was rapidly absorbed into the blood and organs, the maximum levels in the blood and organs being observed 30 minutes and 1 hour after the preparation administration. The preparation levels in the organs with the exception of the liver and kidneys were rather low. The highest levels observed in the kidneys and liver were 19.6 and 3.37 per cent respectively on the RNA-ase amount administered. Within the first 3 hours of the enzyme administration insignificant amounts of the substance were registered in the urine. Penetration of RNA-ase through the hemato-encephalic barrier was low.
D000818:Animals; D001923:Brain Chemistry; D007273:Injections, Intramuscular; D007668:Kidney / Q000032:analysis; D008099:Liver / Q000032:analysis; D008297:Male; D009206:Myocardium / Q000032:analysis; D051381:Rats; D012260:Ribonucleases / Q000008:administration & dosage / Q000032:analysis*; D013154:Spleen / Q000032:analysis; D013302:Streptomyces / Q000201:enzymology*
D012260:Ribonucleases
Rezul'taty izucheniia farmakokinetiki aktinomitsetnoĭ RNK-azy v organizme belykh krys.