The effect of vinblastin and vincristin on single nerve fibres.
The perfusion of the node of Ranvier with vinblastin or vincristin reduces the amplitude of the action potential within a few seconds. Vincristins is 10fold more active than vinblastin. Upon withdrawal, the effect is promptly reversible and its is antagonized by acetylcholine.
D000109:Acetylcholine / Q000494:pharmacology; D000200:Action Potentials / Q000187:drug effects*; D000818:Animals; D001001:Anura; D009474:Neurons / Q000187:drug effects / Q000502:physiology*; D011901:Ranvier's Nodes / Q000187:drug effects / Q000502:physiology*; D012584:Sciatic Nerve / Q000187:drug effects / Q000502:physiology; D014747:Vinblastine / Q000494:pharmacology*; D014750:Vincristine / Q000494:pharmacology*
D014750:Vincristine; D014747:Vinblastine; D000109:Acetylcholine