[The effect of Ro 11-1781, a calciumantagonist, on atrioventricular conduction (author's transl)].
The effect of an intravenous bolus of 1 mg/kg Ro 11-1781, a new calciumantagonist, on sinus node automaticity and intracardiac conduction was studied by His-bundle electrography and atrial stimulation. During sinus rhythm, no significant action of Ro 11-1781 on rate, P-A-interval, A-H interval, and H-V-interval was observed. The sinus node recovery time remained unaltered. On atrial stimulation, the St-H-interval was significantly (p less than 0.001) prolonged after Ro 11-1781. Wenckebach Periods occurred at lower stimulation rates in all patients after Ro 11-1781. It is concluded that Ro 11-1781 prolongs av nodal conduction and may be of  therapeutic value in the treatment of supraventricular arrhythmias.
D000328:Adult; D000368:Aged; D002036:Bundle of His; D002118:Calcium / Q000037:antagonists & inhibitors*; D004562:Electrocardiography; D005260:Female; D006325:Heart Atria; D006329:Heart Conduction System / Q000187:drug effects*; D006339:Heart Rate / Q000187:drug effects; D006571:Heterocyclic Compounds / Q000494:pharmacology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010138:Pacemaker, Artificial; D012849:Sinoatrial Node / Q000187:drug effects
D006571:Heterocyclic Compounds; D002118:Calcium
Die Wirkung von Ro 11-1781, einem Kalziumantagonisten, auf die atrioventrikuläre Uberleitung.