title: Ultrastucture of the male rat hypophysis chronically grafted under the kidney capsule.
abstract: Male rats were divided in two experimental groups. In group I two partes distales of the hypophysis were grafted under the kidney capsule and in group II two complete hypophyses were transplanted. Animals were  killed 5 to 22 months after the operation. The grafted tissue was excised and processed for light and electron microscopy. The transplanted pars distalis tissue showed a well developed vascularisation in contrast to the pars intermedia which appeared poorly vascularised. Six different cell types were observed in grafted pars distalis. They correspond to the different types of cells found in the rat pars distalis "in situ". The predominant cell type in the graft displayed all the morphological characteristics of stimulated prolactotrophs. Pars intermedia cells appeared hypertrophied resembling the MSH cells under stimulation. Two types of syncytial formations were frequently seen. One of them appeared to originate from prolactotrophs and the other from MSH cells. Bodian impregnated fibres and structures resembling either growth cones of axons or typical nerve endings were observed in the pars intermedia of long-term grafted hypophyses. Pituicytes remained as isolated clusters of cells. Canaliculi lined by two or more pituicytes were observed. Saccular formations resembling the hypophyseal cleft appeared in all grafts studied. The present findings suggest that in the male rat the chronically grafted pituitary gland is capable of synthesising most or all the hormones which are known to be produced by the gland "in situ". Furthermore, prolactin and MSH seem to be the predominant secretion of the transplanted pituitary.
mesh_terms: D000818:Animals; D007031:Hypothalamus / Q000502:physiology; D007668:Kidney; D008297:Male; D009074:Melanocyte-Stimulating Hormones / Q000378:metabolism; D008854:Microscopy, Electron; D010902:Pituitary Gland / Q000637:transplantation / Q000648:ultrastructure*; D011388:Prolactin / Q000502:physiology; D051381:Rats; D014182:Transplantation, Autologous
chemical_list: D011388:Prolactin; D009074:Melanocyte-Stimulating Hormones