Steroid profile in a case of adrenal carcinoma with severe hypertension.
The case of a young boy who had Cushing's syndrome and severe hypertension in association with metastatic adrenal carcinoma is described. Marked elevation of the mineralocorticoid 11-deoxycorticosterone was demonstrated in the plasma. 11-Deoxycortisol, 17alpha-hydroxyprogesterone, and urinary tetrahydro-11-deoxycortisol and pregnanetriol were also elevated. Aldosterone excretion was low. The data implicate defective 11beta hydroxylation and suggest that excessive 11-deoxycorticosterone production may have been responsible for the hypertension.
D015065:17-Hydroxycorticosteroids / Q000652:urine*; D015068:17-Ketosteroids / Q000652:urine*; D000305:Adrenal Cortex Hormones / Q000378:metabolism*; D000310:Adrenal Gland Neoplasms / Q000150:complications / Q000378:metabolism*; D000450:Aldosterone / Q000652:urine; D002277:Carcinoma / Q000150:complications / Q000378:metabolism*; D002648:Child; D003350:Cortodoxone / Q000097:blood; D003900:Desoxycorticosterone / Q000097:blood; D006801:Humans; D006854:Hydrocortisone / Q000097:blood; D006908:Hydroxyprogesterones / Q000097:blood; D006973:Hypertension / Q000209:etiology*; D008297:Male; D011279:Pregnanetriol / Q000652:urine
D015065:17-Hydroxycorticosteroids; D015068:17-Ketosteroids; D000305:Adrenal Cortex Hormones; D006908:Hydroxyprogesterones; D011279:Pregnanetriol; D003900:Desoxycorticosterone; D000450:Aldosterone; D003350:Cortodoxone; D006854:Hydrocortisone