Photo-onycholysis induced by 8-methoxypsoralen.
Two patients, who we had under surveillance since 1969, were found to develop photo-onycholysis from orally administered 8-methoxypsoralen and sunlight irradiation. Morphological examination of the nail bed revealed characteristics of a microtrauma. The photosensitizing effect of the drug induced the generation numerous binucleate, tetranucleate and multinucleate epithelial cells as well as numerous binucleate and tetranucleate fibroblasts in the dermis.
D000284:Administration, Oral; D000328:Adult; D003594:Cytoplasmic Granules / Q000648:ultrastructure; D004847:Epithelial Cells; D004848:Epithelium / Q000648:ultrastructure; D005260:Female; D005347:Fibroblasts / Q000648:ultrastructure; D006801:Humans; D008297:Male; D008730:Methoxsalen / Q000008:administration & dosage / Q000009:adverse effects* / Q000627:therapeutic use; D009262:Nails / Q000187:drug effects* / Q000473:pathology / Q000648:ultrastructure; D010787:Photosensitivity Disorders / Q000139:chemically induced*; D012270:Ribosomes / Q000648:ultrastructure; D012871:Skin Diseases / Q000139:chemically induced / Q000473:pathology; D013472:Sunlight; D014820:Vitiligo / Q000188:drug therapy
D008730:Methoxsalen