[L-DOPA test for evaluating in vivo catecholamine biosynthesis in normal persons and persons with different diseases].
Administration of 1-DOPA into healthy persons increased its excretion with urine and elevated the adrenaline secretion. The increase of catecholamines excretion was not observed in aged patients with hypertension; the data obtained suggest that the synthesis of catecholamines with utilization of DOPA was inhibited. In patients with ulcerous disease excretion of 1-DOPA was not increased after its administration, but secretion of catecholamines was decreased during the day time. Under ulcerous disease 1-DOPA appears to be used in process unrelated to synthesis of catecholamines.
D000328:Adult; D000368:Aged; D001161:Arteriosclerosis / Q000652:urine*; D002395:Catecholamines / Q000652:urine*; D002940:Circadian Rhythm; D004295:Dihydroxyphenylalanine / Q000652:urine; D004298:Dopamine / Q000652:urine; D004837:Epinephrine / Q000652:urine; D005260:Female; D006801:Humans; D006973:Hypertension / Q000652:urine*; D007980:Levodopa; D008297:Male; D008875:Middle Aged; D009638:Norepinephrine / Q000652:urine; D013276:Stomach Ulcer / Q000652:urine*
D002395:Catecholamines; D007980:Levodopa; D004295:Dihydroxyphenylalanine; D004298:Dopamine; D009638:Norepinephrine; D004837:Epinephrine
Proba s vvedeniem L-DOFA dlia otsenki in vivo biosinteza katekholaminov u cheloveka v norme i patologii.