Convulsions associated with sodium cefazolin: a case report.
Our patient was severely injured, and had a prolonged period of hypotension. After operation she received moderate doses of cefazolin, intravenously, in the face of acute renal failure. Seizures associated with a serum cefazolin level of 455 mg/ml were observed. Although a cause and effect relationship between high cefazolin levels and neurotoxicity cannot be proven conclusively, the implication of this relationship exists. The clinician should be aware of the potential neurotoxicity of this commonly used drug. The importance of adjusting the dose in patients with renal failure is re-emphasized.
D058186:Acute Kidney Injury / Q000097:blood; D002437:Cefazolin / Q000008:administration & dosage / Q000009:adverse effects* / Q000097:blood; D002511:Cephalosporins / Q000009:adverse effects*; D004342:Drug Hypersensitivity / Q000097:blood; D005260:Female; D006801:Humans; D007263:Infusions, Parenteral; D007677:Kidney Function Tests; D008875:Middle Aged; D011183:Postoperative Complications / Q000097:blood; D012640:Seizures / Q000139:chemically induced*; D013530:Surgical Wound Infection / Q000517:prevention & control; D014949:Wounds, Nonpenetrating / Q000601:surgery
D002511:Cephalosporins; D002437:Cefazolin