title: Mobilization of hematopoietic stem cells (CFU-C) into the peripheral blood of man by endotoxin.
abstract: Pseudomonas endotoxin was administered to three normal subjects in order to assess possible effects on stem cell circulation. Increased numbers of granulopoietic stem cells (CFU-C) transiently appeared in the peripheral blood, reaching a maximum after the time of maximal leukopenia. There was a mean 4-fold increase in CFU-C per ml of blood following endotoxin. A high proportion of these CFU-C did not require an added source of colony-stimulating activity for growth in agar.
mesh_terms: D000328:Adult; D001772:Blood Cell Count; D004731:Endotoxins / Q000494:pharmacology*; D006098:Granulocytes / Q000187:drug effects*; D006410:Hematopoiesis / Q000187:drug effects*; D006412:Hematopoietic Stem Cells / Q000187:drug effects*; D006801:Humans; D007958:Leukocyte Count; D007962:Leukocytes / Q000187:drug effects*; D011549:Pseudomonas
chemical_list: D004731:Endotoxins