[Pre-synaptic effect of histidine at neuromuscular junctions].
The influence of L-histidine in different concentrations (0.2--9.0mM) on synaptic processes in neuro-muscular preparations of the frog was studied using intracellular microelectrodes. The histidine caused lowering of the frequency of m. e. p. p. In the synapses with initial quantum content of e. p. p. less than 50, the increase of quantum content occurred due to rising of the available mediator level. The possibility of the transmitter release did not change. The histidine seems to participate in positive functional feedback in a neuro-muscular synapse, the feedback maybe essential for mobilization of the inactive synapses during intense muscular activity.
D000818:Animals; D001001:Anura; D006639:Histidine / Q000494:pharmacology*; D008564:Membrane Potentials / Q000187:drug effects*; D009469:Neuromuscular Junction / Q000187:drug effects*
D006639:Histidine
O presinapticheskom deĭstvii gistidina v nervno-myshechnom soedinenii.