Dual effect of disopyramide on atrial and atrioventricular conduction and refractory periods.
Disopyramide has been shown in conditions of cholinergic blockade to have a depressant effect upon sinus node automaticity and the atrial refractoriness. It also prolongs atrioventricular conduction and increases atrioventricular refractoriness. These effects may often be masked in vivo by the anticholinergic effects of the drug.
D000293:Adolescent; D000328:Adult; D000368:Aged; D001145:Arrhythmias, Cardiac / Q000503:physiopathology; D001283:Atrioventricular Node / Q000187:drug effects*; D001285:Atropine / Q000494:pharmacology; D004206:Disopyramide / Q000494:pharmacology*; D005260:Female; D006321:Heart / Q000294:innervation; D006325:Heart Atria / Q000187:drug effects*; D006329:Heart Conduction System / Q000187:drug effects*; D006352:Heart Ventricles / Q000187:drug effects; D006801:Humans; D008297:Male; D008875:Middle Aged; D009431:Neural Conduction / Q000187:drug effects*; D010275:Parasympathetic Nervous System / Q000187:drug effects / Q000502:physiology; D011725:Pyridines / Q000494:pharmacology*; D012032:Refractory Period, Electrophysiological / Q000187:drug effects*
D011725:Pyridines; D001285:Atropine; D004206:Disopyramide