New approaches to the study of angiotensin tachyphylaxis.
Of the various mechanisms proposed to explain the development of tachyphylaxis, the initial step of drug-receptor interaction has received the most attention. The present study suggests that the affinity of angiotensin II itself or an angiotensin analogue for the angiotensin receptor is a determing factor in the development of tachyphylaxis. The concept of negative cooperativity is introduced as a consequence of the observed correlation in the present study between slopes of less than unity as determined in Hill plots and the development of tachyphylaxis.
D000804:Angiotensin II / Q000031:analogs & derivatives / Q000494:pharmacology*; D000818:Animals; D001011:Aorta / Q000187:drug effects / Q000502:physiology*; D004305:Dose-Response Relationship, Drug; D005260:Female; D066298:In Vitro Techniques; D009119:Muscle Contraction / Q000187:drug effects*; D011817:Rabbits; D051381:Rats; D013618:Tachyphylaxis
D000804:Angiotensin II