Antagonism by haloperidol of locomotor depression induced by small doses of apomorphine.
Administration of 0.025--0.1 mg/kg of apomorphine i.p. to mice produced a dose-dependent locomotor depression. Haloperidol, 0.025 mg/kg, produced locomotor stimulation, whereas 0.1 mg/kg caused locomotor depression. Pretreatment with haloperidol also reversed the depression caused by apomorphine. The functional antagonism is discussed in terms of a possible agonist-antagonist interaction on dopaminergic autoreceptors.
D000818:Animals; D001058:Apomorphine / Q000037:antagonists & inhibitors*; D003864:Depression, Chemical; D004305:Dose-Response Relationship, Drug; D005260:Female; D006220:Haloperidol / Q000494:pharmacology*; D051379:Mice; D009043:Motor Activity / Q000187:drug effects*; D013997:Time Factors
D006220:Haloperidol; D001058:Apomorphine