title: 3,4,3',4'-tetrachloroazobenzene: a potential environmental toxicant.
abstract: 3,4,3',4'-tetrachloroazobenzene (TCAB), a potential environmental toxicant formed in the industrial manufacturing and the microbial degradation of chloroanilide herbicides, has been prepared in 87% yield by an improved procedure. In vitro experiments with C3H/10T1/2 cells have shown that TCAB is toxic to mammalian cells, which may be correlated with observable cytological changes. TCAB has also been found to be weakly mutagenic by the Salmonella/microsome test. In addition, C3H/10T1/2 cells are transformed following a ten day incubation with TCAB. These data suggest the potential health hazard associated with the environmental occurrence of TCAB.
mesh_terms: D000818:Animals; D001391:Azo Compounds / Q000633:toxicity*; D002722:Chlorobenzenes / Q000633:toxicity*; D004785:Environmental Pollutants; D005347:Fibroblasts / Q000187:drug effects; D051379:Mice; D009154:Mutation
chemical_list: D001391:Azo Compounds; D002722:Chlorobenzenes; D004785:Environmental Pollutants; C013279:3,4,3',4'-tetrachloroazobenzene