The prophylaxis of malignant hyperthermia by oral dantrolene sodium in swine.
The oral administration of dantrolene for the prophylaxis of malignant hyperthermia (MH) in susceptible swine has been investigated. Complete protection from MH in pigs exposed to the known MH initiating agents, halothane and suxamethonium, was demonstrated.
D000284:Administration, Oral; D000768:Anesthesia, General / Q000009:adverse effects; D000769:Anesthesia, Inhalation; D000818:Animals; D003620:Dantrolene / Q000008:administration & dosage / Q000627:therapeutic use*; D006221:Halothane; D006827:Hydantoins / Q000627:therapeutic use*; D008305:Malignant Hyperthermia / Q000517:prevention & control*; D013390:Succinylcholine; D013552:Swine
D006827:Hydantoins; D003620:Dantrolene; D013390:Succinylcholine; D006221:Halothane