Phenobarbital drinking curves after varied water deprivation.
The phenobarbital dose-drinking response curves were obtained for 11 1/2 and 23 1/2 hr of water deprivation in rats. The results indicated that the same quadratic curve was found in both cases displaced as a function of degree of deprivation. These results are explicable by regarding phenobarbital as an adequate stimulus for drinking or by disinhibiting drinking if level of inhibition is not directly concerned with regulation of water ingestion per se. The response to phenobarbital upon the days following injection is similar for both degrees of deprivation investigated.
D000818:Animals; D004305:Dose-Response Relationship, Drug; D004327:Drinking Behavior / Q000187:drug effects*; D008297:Male; D010634:Phenobarbital / Q000494:pharmacology*; D051381:Rats; D013997:Time Factors; D014868:Water Deprivation
D010634:Phenobarbital