title: The effect of chronic heparin administration on the mineralization of an experimental osseous defect.
abstract: Adult roosters with experimental circular osteotomy defects in the metatarsus were placed on chronic heparin therapy. In vivo measurement of bone mineral content changes of the osteotomy using Iodine-125 show no adverse affect of heparin treatment on remineralization. However, the weight of dry-defatted femurs was decreased and suggests that there was significant heparin-induced systemic bone demineralization.
mesh_terms: D000818:Animals; D001861:Bone Regeneration / Q000187:drug effects*; D001842:Bone and Bones / Q000032:analysis; D002645:Chickens; D006493:Heparin / Q000494:pharmacology*; D008297:Male; D008903:Minerals / Q000032:analysis; D010015:Osteolysis, Essential / Q000139:chemically induced; D010027:Osteotomy
chemical_list: D008903:Minerals; D006493:Heparin