title: A possible role for malonyl-CoA in the regulation of hepatic fatty acid oxidation and ketogenesis.
abstract: Studied on the oxidation of oleic and octanoic acids to ketone bodies were carried out in homogenates and in mitochondrial fractions of livers taken from fed and fasted rats. Malonyl-CoA inhibited ketogenesis from the former but not from the latter substrate. The site of inhibition appeared to be the carnitine acyltransferase I reaction. The effect was specific and easily reversible. Inhibitory concentrations were in the range of values obtained in livers from fed rats by others. It is proposed that malonyl-CoA functions as both precursor for fatty acid synthesis and suppressor of fatty acid oxidation. As such, it might be an important element in the carbohydrate-induced sparing of fatty acid oxidation.
mesh_terms: D000818:Animals; D002210:Caprylates / Q000378:metabolism; D002331:Carnitine / Q000031:analogs & derivatives / Q000378:metabolism; D003065:Coenzyme A / Q000494:pharmacology* / Q000502:physiology; D005227:Fatty Acids / Q000378:metabolism*; D007657:Ketone Bodies / Q000096:biosynthesis*; D008099:Liver / Q000378:metabolism*; D008297:Male; D008314:Malonates; D008930:Mitochondria, Liver / Q000378:metabolism; D008954:Models, Biological; D009829:Oleic Acids / Q000378:metabolism; D010084:Oxidation-Reduction; D051381:Rats
chemical_list: D002210:Caprylates; D005227:Fatty Acids; D007657:Ketone Bodies; D008314:Malonates; D009829:Oleic Acids; D002331:Carnitine; D003065:Coenzyme A