Renal hemodynamics in HgCl2-induced acute renal failure.
Renal blood flow (RBF), outer cortical blood flow (OC-rbf) and inner cortical blood flow were determined by the microsphere method in water-drinking rats and chronic saline-drinking rats at 3, 12 and 24 h after injection of HgCl2, 4.7 mg/kh body weight. RFB and OC-rbf were decreased in both groups at 3 h post HgCl2 injection. Persistent reduction of OC-rbf was noted in water-drinking rats at 12 and 24 h post HgCl2 even though the total RBF returned to normal by 24 h. These parameters were normal in chronic saline-drinking rats. Despite normal RBF in water-drinking and saline-drinking rats, serum creatinines were still signigicantly elevated 24 h post HgCl2. Therefore, alterations in total renal perfusion do not entirely account for the decreased renal function that occurs under these circumstances.
D058186:Acute Kidney Injury / Q000209:etiology / Q000503:physiopathology*; D000818:Animals; D003404:Creatinine / Q000097:blood; D004195:Disease Models, Animal; D006439:Hemodynamics; D007668:Kidney / Q000098:blood supply*; D007672:Kidney Cortex / Q000098:blood supply; D008297:Male; D008630:Mercury Poisoning / Q000150:complications*; D008863:Microspheres; D051381:Rats; D012039:Regional Blood Flow; D012965:Sodium Chloride / Q000008:administration & dosage; D014867:Water
D014867:Water; D012965:Sodium Chloride; D003404:Creatinine