title: Preliminary study of the intense sympathetic discharge induced centrally after lateral ventricular administration of whole venom of Dendroaspis polylepis.
abstract: Lateral ventricular administration of 100 microgram of Dendroaspis polylepis venom is cats consistently produced a marked rise in arterial blood pressure, heart rate dilatation of pupils and piloerection. This intense central sympathetic discharge occurred after a latent period of 11.7 +/- 0.72 min. Bilateral adrenelectomy abolished the sympathetic discharge showing that central release of catecholamines from the adrenal medulla may play an important role in elicting the cardiovascular response.
mesh_terms: D000315:Adrenalectomy; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D002415:Cats; D005260:Female; D006339:Heart Rate / Q000187:drug effects; D007276:Injections, Intraventricular; D008297:Male; D011680:Pupil / Q000187:drug effects; D012910:Snake Venoms / Q000008:administration & dosage / Q000494:pharmacology*; D013564:Sympathetic Nervous System / Q000187:drug effects*
chemical_list: D012910:Snake Venoms