title: Styrene and acrylonitrile induced depression of hepatic nonprotein sulfhydryl content in various rodent species.
abstract: Adult female mice, male rats, female hamsters and male guinea pigs received various doses of styrene (150-1000 mg/kg of body weight) and acrylonitrile (20-80 mg/kg of body weight) intraperitoneally. Both styrene and acrylonitrile caused a depression of the hepatic nonprotein sulfhydryl content. Mouse was the most vulnerable and rat the most resistant species to the effect of both of these two important plastic monomers.
mesh_terms: D000181:Acrylonitrile / Q000494:pharmacology*; D000818:Animals; D006224:Cricetinae; D003864:Depression, Chemical; D005260:Female; D006168:Guinea Pigs; D008099:Liver / Q000187:drug effects / Q000378:metabolism*; D008297:Male; D008647:Mesocricetus; D051379:Mice; D009570:Nitriles / Q000494:pharmacology*; D051381:Rats; D013045:Species Specificity; D013343:Styrenes / Q000494:pharmacology*; D013438:Sulfhydryl Compounds / Q000378:metabolism*; D013997:Time Factors
chemical_list: D009570:Nitriles; D013343:Styrenes; D013438:Sulfhydryl Compounds; D000181:Acrylonitrile