title: Multiple germ cell tumors: reports of 3 cases, 1 with 3 primary lesions.
abstract: Tumors may develop in both testes, either concomitantly or sequentially. We herein report 3 cases of bilateral testicular neoplasms. One patient had concomitant seminomas of the testes and another had sequential germ cell tumors separated by an 11-year interval. The third patient is an unusual case in that he had bilateral testicular germ cell tumors diagnosed concomitantly 8 years after irradiation of an extragonadal, histologically proved, seminoma in the mediastinum. Evidence suggests that all 3 sites, each testis and the mediastinum, were primary lesions. Standard methods of therapy should be used in the treatment of malignancies.
mesh_terms: D000328:Adult; D004407:Dysgerminoma / Q000628:therapy; D006801:Humans; D008297:Male; D008479:Mediastinal Neoplasms / Q000532:radiotherapy; D008875:Middle Aged; D009378:Neoplasms, Multiple Primary / Q000628:therapy; D013724:Teratoma / Q000532:radiotherapy; D013736:Testicular Neoplasms / Q000628:therapy*