A specific and rapid determination of human skin dihydrotestosterone cytosol receptor.
The 5 alpha-Dihydrotestosterone (DHT) receptor in cytosol prepared from foreskin fragments was identified and measured by polyacrylamide gel electrophoresis (PAGE). 14 normal subjects, 4 boys with hypospadias and two patients with male pseudohermaphroditism (MPH) were studied. The amount of DHT receptor was comparable in the normal subjects and those with hypospadias. No receptor was found in the 2 cases of MPH.
D000293:Adolescent; D000328:Adult; D002648:Child; D002675:Child, Preschool; D003600:Cytosol / Q000378:metabolism; D013196:Dihydrotestosterone / Q000378:metabolism*; D012734:Disorders of Sex Development / Q000378:metabolism; D004591:Electrophoresis, Polyacrylamide Gel; D006801:Humans; D007021:Hypospadias / Q000378:metabolism; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D008722:Methods; D008875:Middle Aged; D011944:Receptors, Androgen / Q000378:metabolism*; D011987:Receptors, Steroid / Q000378:metabolism*; D012867:Skin / Q000378:metabolism*
D011944:Receptors, Androgen; D011987:Receptors, Steroid; D013196:Dihydrotestosterone