[Comparison of the effect of chloridin on rat embryos during postimplantation periods of development in vivo and in vitro].
The effect of chloridin (2,4-diamino-5-parachlorophenyl-6-ethylpyrimidine) on the rat embryos developing in the maternal organism and on the embryos explanted 24 hrs after the treatment in the nutrient medium (homologous blood serum) was compared. The pathological processes both in vivo and in vitro were shown to be similar. The number of atypical and died embryos in vitro was, however, much higher, apparently due to the absence of some protective membranes in the cultivated embryos.
D000014:Abnormalities, Drug-Induced; D000818:Animals; D046508:Culture Techniques; D047108:Embryonic Development; D005260:Female; D005313:Fetal Death / Q000139:chemically induced*; D008431:Maternal-Fetal Exchange; D011247:Pregnancy; D011739:Pyrimethamine / Q000506:poisoning*; D051381:Rats
D011739:Pyrimethamine
Sravneie deĭstviia khloridina na zarodysheĭ krys postimplantatsionnykh srokov razvitiia v opytakh in vito i in vitro.