title: [Substrate inhibition as a cause of oscillations in an open irreversible enzymic reaction S1 + S2 in the presence of E(R,T) leads to S1' + S2'. A mathematical model].
abstract: A mathematical model of an open irreversible reaction S1 + S2 (formula: see text) catalysed by an olygomeric enzyme E(R, T) has been analysed. It is assumed that the enzyme undergoes the concerted conformational transitions R in equilibrium T in conformity with the theory of Monod, Wyman and Changeux, and one of the substrates (S2) produces inhibition of the enzyme, thus shifting the equilibrium between the two enzyme forms in the direction of T formation. A simple graphical explanation is given to the hysteresis of the input characteristic approximately v ([S1]) (approximately v is the reaction rate at d[S2]/dt=O) which gives rise to self--oscillations. The hysteresis occurs both in the case of allosteric and isosteric substrate inhibition.
mesh_terms: D000494:Allosteric Regulation; D004791:Enzyme Inhibitors / Q000494:pharmacology*; D004798:Enzymes / Q000378:metabolism*; D007700:Kinetics; D046911:Macromolecular Substances; D008433:Mathematics; D008956:Models, Chemical; D011487:Protein Conformation
chemical_list: D004791:Enzyme Inhibitors; D004798:Enzymes; D046911:Macromolecular Substances
vernacular_title: Substratnoe ugnetenie--prichina kolebaniĭ v otkrytoĭ neobratimoĭ fermentativnoĭ reaktsii S1 + S2 e(r,t) S1' + S2'. Matematicheskaia model'