Management of prolonged hypoglycaemia in Beckwith's syndrome.
A new-born baby with Beckwith's syndrome had severe hypoglycaemia, and was treated with glucagon and prednisone. Treatment was stopped at 1 month of age and his blood glucose levels were satisfactory for the ensuing 6 weeks. However, at 10 weeks of age, he had a hypoglycaemic convulsion and required large doses of diazoxide and prednisone for the next 2 months to maintain the blood glucose above 40 mg/100 ml. Insulin excretion was raised until he was 4 months old. Cases of Beckwith's syndrome which develop hypoglycaemia, should be treated with diazoxide and corticosteroids until insulin excretion is normal.
D000015:Abnormalities, Multiple; D000305:Adrenal Cortex Hormones / Q000627:therapeutic use; D003981:Diazoxide / Q000627:therapeutic use; D006554:Hernia, Umbilical / Q000151:congenital; D006801:Humans; D007003:Hypoglycemia / Q000209:etiology*; D007223:Infant; D007231:Infant, Newborn; D007232:Infant, Newborn, Diseases / Q000188:drug therapy*; D008260:Macroglossia; D008297:Male; D013577:Syndrome
D000305:Adrenal Cortex Hormones; D003981:Diazoxide