Effects of topically potent glucocorticoids on human diploid fibroblasts in vitro.
A wide range of concentrations of both cortisol and a topically more potent synthetic derivative, fluocinolone acetonide, was found not to inhibit the growth of cultured human skin fibroblasts; fluocinolone acetonide produced a slight increase in the growth rate. Both steroids had a transient stimulatory effect on fibroblasts, promoting an earlier entry into the period DNA synthesis (S) which was also accompanied by a substantial increase in the length of S.
D002455:Cell Division / Q000187:drug effects; D002478:Cells, Cultured; D004247:DNA / Q000096:biosynthesis; D004171:Diploidy; D005347:Fibroblasts / Q000187:drug effects* / Q000378:metabolism; D005446:Fluocinolone Acetonide / Q000494:pharmacology*; D006801:Humans; D006854:Hydrocortisone / Q000494:pharmacology*; D008938:Mitosis / Q000187:drug effects; D013997:Time Factors
D005446:Fluocinolone Acetonide; D004247:DNA; D006854:Hydrocortisone