Effect of sex and age at gonadectomy on the sebaceous response to progesterone.
The effect of progesterone on the rate of sebum secretion was examined in intact and gonadectomized rats. In intact, adult, male rats, progesterone administered for 3 weeks decreased sebum secretion; after castration of adult males, progesterone increased sebum secretion and an even greater response occurred in male castrated at 21 days of age. In intact, adult, female rats progesterone slightly increased sebum production. As in the male, the response was affected by the time of gonadectomy, a greater response occurring after spaying at 21 days compared with 10 weeks of age. Thus, the response to progesterone in the adult rat differs in intact males and females and is affected by changes in the endocrine environment induced by gonadectomy, especially near the time of puberty.
D000367:Age Factors; D000818:Animals; D002369:Castration; D005260:Female; D008297:Male; D011374:Progesterone / Q000494:pharmacology*; D051381:Rats; D012627:Sebaceous Glands / Q000187:drug effects*; D012629:Sebum / Q000378:metabolism*; D012737:Sex Factors; D013268:Stimulation, Chemical
D011374:Progesterone