Determination of the isoniazid acetylator phenotype in a West African population.
The concentration of isoniazid in plasma after an oral dose of 10 mg/kg was estimated in 120 Nigerians (39 normal, 81 tuberculous). The concentrations were bimodally distributed giving a good discrimination between slow and rapid acetylators. The proportion of rapid to slow acetylators in the whole group was 60:40. This is similar to the results of the only other study of acetylator phenotype in West Africans.
D000107:Acetylation; D044383:Black People; D006801:Humans; D007538:Isoniazid / Q000378:metabolism*; D009549:Nigeria; D010641:Phenotype; D013997:Time Factors; D014397:Tuberculosis, Pulmonary / Q000453:epidemiology / Q000378:metabolism*
D007538:Isoniazid