Effects of fluorocarbon propellants on respiratory flow and ECG.
Ten subjects were exposed to the propellants freon 11, freon 12, freon 114, to two mixtures of freon 11 and 12 and to a mixture of freon 12 and 114. The length of exposure was 15, 45 or 60 seconds. Maximum expiratory flow-volume (MEF) curves and ECG were recorded before, and intermittently up to 1 hour after, exposure. Breathing level concentrations of propellants during exposure were determined by gas chromatography. All freons induced biphasic reduction of ventilatory capacity on inhalation. The first fall occurred within a few minutes of exposure while the second was delayed 13-30 minutes after exposure. The effects of mixtures were greater than those of individual freons. The relative fall in MEF 75% was more pronounced than that in MEF 50%. No clear-cut pathological changes in ECG were found. Nevertheless, most subjects developed variations in heart rate exceeding those noted before exposure. In a few cases inversion of the T wave, and in one case atrioventricular block, were observed.
D000328:Adult; D000335:Aerosol Propellants / Q000494:pharmacology*; D000336:Aerosols / Q000494:pharmacology*; D005617:Chlorofluorocarbons, Methane / Q000494:pharmacology*; D004562:Electrocardiography; D006321:Heart / Q000187:drug effects*; D006327:Heart Block / Q000139:chemically induced; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D008297:Male; D008449:Maximal Expiratory Flow-Volume Curves; D012123:Pulmonary Ventilation / Q000187:drug effects*; D013268:Stimulation, Chemical
D000335:Aerosol Propellants; D000336:Aerosols; D005617:Chlorofluorocarbons, Methane