[State of microcirculatory hemostasis in arterial hypertension and its changes under the effect of heparin].
The state of microcirculatory haemostasis was studied in 145 patients with essential hypertension with reference to the severity of their disease. It was noted that along with the growing duration and severity of the disease the aggregation activity of the platelets is decreasing. Intravenous administration of Heparin, 5, 10, 15, 20 and 25 thousand units, significantly activates the platelets of normal individuals (30 persons) and of hypertonics. The activation develops by the end of Heparin infusion, persists for 2 hours and is clearly perseptible 48 hours following a course of Heparin therapy. The sanogenic role of Heparin-induced activation of the microcirculatory haemostasis in the adaptation-haemostatic reactions is discussed.
D006487:Hemostasis; D006493:Heparin / Q000494:pharmacology / Q000627:therapeutic use*; D006801:Humans; D006973:Hypertension / Q000097:blood / Q000503:physiopathology*; D008833:Microcirculation / Q000187:drug effects; D010974:Platelet Aggregation / Q000187:drug effects; D013927:Thrombosis / Q000517:prevention & control
D006493:Heparin
Sostoianie mikrotsirkuliatornogo gemostaza u bol'nykh arterial'noĭ gipertonieĭ i ego izmeneniia pod deistviem geparina.