Radioimmunoassay for abnormal hemoglobins.
A sensitive and specific radioimmunoassay has been developed for the identification or quantification of the human hemoglobin variants S, C, D-Los Angeles, E, G Philadelphia, Russ, O Arab, Beograd, J Paris I, G San Jose, Q Iran, Korle Bu, and F Malta I. In the immunoassay, monospecific antibody preparations are used which recognize the single amino acid substitution in the variant polypeptide chail and do not cross-react with normal hemoglobins or hemoglobin variants containing a different amino acid exchange at the same position.
D000595:Amino Acid Sequence; D000918:Antibody Specificity; D003429:Cross Reactions; D004306:Dose-Response Relationship, Immunologic; D006444:Hemoglobin C / Q000032:analysis; D006446:Hemoglobin E / Q000032:analysis; D006451:Hemoglobin, Sickle / Q000032:analysis; D006455:Hemoglobins, Abnormal / Q000032:analysis* / Q000276:immunology; D006801:Humans; D011863:Radioimmunoassay
D006451:Hemoglobin, Sickle; D006455:Hemoglobins, Abnormal; D006444:Hemoglobin C; D006446:Hemoglobin E