title: Role of drug concentration, duration of exposure, and endogenous metabolites in determining methotrexate cytotoxicity.
mesh_terms: D000818:Animals; D001853:Bone Marrow / Q000187:drug effects; D001854:Bone Marrow Cells; D002455:Cell Division / Q000187:drug effects; D002470:Cell Survival / Q000187:drug effects*; D002478:Cells, Cultured; D004247:DNA / Q000096:biosynthesis; D005492:Folic Acid / Q000031:analogs & derivatives / Q000502:physiology; D006801:Humans; D066298:In Vitro Techniques; D008727:Methotrexate / Q000009:adverse effects* / Q000378:metabolism; D009994:Osmolar Concentration; D011684:Purine Nucleosides / Q000502:physiology; D013997:Time Factors
chemical_list: D011684:Purine Nucleosides; D004247:DNA; D005492:Folic Acid; D008727:Methotrexate