The comparative fine structure of the interhemal membrane of chorioallantoic placentas from six genera of myomorph rodents.
In order to extend the cytological information available on the structure of the interhemal membrane in cricetid rodents, in particular, and myomorph rodents, in general, we have examined the fine structure of the placental labyrinth in five genera of cricetid rodents (Lemmus, Dicrostonyx, Clethrionomys, Microtus and Peromyscus) and one genus of murid rodent (Acomys). Small pieces of labyrinth from near-term placentas were fixed in glutaraldehyde and osmium tetroxide and processed for electron microscopy. The interhemal membranes of all the species examined were hemotrichorial. The outermost layer of trophoblast, bordering the maternal blood spaces, was cellular and often contained some patent fenestrae, whereas the middle and linner trophoblastic layers were apparently syncytial. The outermost trophoblastic layer of all the species contained abundant granular endoplasmic reticulum. The intercellular space between the outer and middle layers was variable in width, primarily due to the complex folding of the surface of the middle layer. The surfaces of the middle and inner layers were closely apposed. The middle trophoblastic layer in several species contained filamentous "glomerular bodies" and the innermost layer, particularly of Peromyscus, contained smooth membranous whorls. A basal lamina separated the innermost trophoblastic layer from the fetal capillary endothelium. The endothelial cells in most of the species contained fenestrated regions. These observations are compared to those on other hemochorial placentas, and common features of cricetid (and myomorph) rodent placental find structure are emphasized.
D000818:Animals; D002196:Capillaries / Q000648:ultrastructure; D005260:Female; D005333:Fetus / Q000033:anatomy & histology; D010920:Placenta / Q000648:ultrastructure*; D011247:Pregnancy; D011270:Pregnancy, Animal; D012377:Rodentia / Q000033:anatomy & histology*; D013045:Species Specificity; D014327:Trophoblasts / Q000648:ultrastructure