Inhibition of catechol O-methyltransferase and transfer RNA methyltransferases by coralyne, nitidine, and related compounds.
Inhibitory activity against both catechol O-methyltransferase and transfer RNA methyltransferases was observed among the antileukemic alkaloids coralyne, nitidine, and related synthetic alkoxy analogs. Inhibition of both classes of enzymes seems to have a similar profile. The role of water solubility of these compounds with regard to their enzyme inhibitory activity was noted.
D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000494:pharmacology*; D053119:Benzophenanthridines; D001600:Berberine Alkaloids / Q000494:pharmacology*; D065098:Catechol O-Methyltransferase Inhibitors; D066298:In Vitro Techniques; D008099:Liver / Q000201:enzymology; D008297:Male; D010617:Phenanthridines / Q000494:pharmacology*; D051381:Rats; D012995:Solubility; D012359:tRNA Methyltransferases / Q000037:antagonists & inhibitors*
D000972:Antineoplastic Agents, Phytogenic; D053119:Benzophenanthridines; D001600:Berberine Alkaloids; D065098:Catechol O-Methyltransferase Inhibitors; D010617:Phenanthridines; C000666:coralyne; C013615:nitidine; D012359:tRNA Methyltransferases