title: Studies of the metabolic fate of p-hydroxybenzoic acid in male and female cats.
abstract: Metabolic studies conducted on p-hydroxybenzoic acid orally administered at dose levels of 13 and 26 mg/kg to male and female cats have shown that the compound is rapidly excreted in the urine exclusively in the form of the glycine conjugate p-hydroxyhippuric acid. Similar results were obtained following either single administration or 7-day treatment. The metabolite in the urine was characterised by thin-layer chromatography, amino acid analysis and mass spectrometry.
mesh_terms: D000596:Amino Acids / Q000652:urine; D000818:Animals; D002415:Cats; D002855:Chromatography, Thin Layer; D004032:Diet; D005243:Feces / Q000032:analysis; D005260:Female; D062385:Hydroxybenzoates / Q000008:administration & dosage / Q000378:metabolism* / Q000652:urine; D008297:Male; D013058:Mass Spectrometry; D013997:Time Factors
chemical_list: D000596:Amino Acids; D062385:Hydroxybenzoates