Regional chromosomal localization of the human gene for galactose-1-phosphate uridyltransferase.
In the progeny of somatic cell hybrids formed by fusion of human lymphocytes and Chinese hamster mutant cells, a single human chromosome A2 was selectively retained when grown in appropriate medium. Spontaneous breakage of this chromosome in different hybrid subclones led to the assignment of the gene for galactose-1-phosphate uridyltransferase to the centromeric region of this chromosome (2q11 leads to 2q14). This gene is shown to be syntenic to the previously mapped genes for acid phosphatase 1 and malate dehydrogenase 1.
D000135:Acid Phosphatase; D000818:Animals; D002874:Chromosome Mapping; D002900:Chromosomes, Human, 1-3; D006224:Cricetinae; D005796:Genes; D006801:Humans; D006822:Hybrid Cells; D008214:Lymphocytes; D008291:Malate Dehydrogenase; D008297:Male; D009154:Mutation; D009713:Nucleotidyltransferases; D006599:UDPglucose-Hexose-1-Phosphate Uridylyltransferase
D008291:Malate Dehydrogenase; D009713:Nucleotidyltransferases; D006599:UDPglucose-Hexose-1-Phosphate Uridylyltransferase; D000135:Acid Phosphatase