title: [Morphology of the spleen and immune response in experimental nutritional deficiency in rats].
abstract: The author examined 60 white rats of the strain "Wistar" with initial age of four months and body weight of 180--220 gm, subjecter to nutritive deficit regimens with various protein content. He described the morphological changes in the spleen, made a qualitative analysis of IgG and IgM in serum and examined also some links of the immune response after antigen stimulation with human gamma-globulin. Very limited nutrition (5,74 of protein) for 16 weeks caused immune deficit with definite morphological substrate-atrophy and fibrosis of the lymphoid tissue. Moderate limited feeding (11, 48% of protein) did not induce substantial deviations from the functions the immune system.
mesh_terms: D000818:Animals; D000937:Antigen-Antibody Reactions; D001284:Atrophy; D004044:Dietary Proteins; D007074:Immunoglobulin G / Q000032:analysis; D007075:Immunoglobulin M / Q000032:analysis; D008221:Lymphoid Tissue / Q000473:pathology; D009748:Nutrition Disorders / Q000276:immunology*; D051381:Rats; D013154:Spleen / Q000276:immunology* / Q000473:pathology; D013997:Time Factors
chemical_list: D004044:Dietary Proteins; D007074:Immunoglobulin G; D007075:Immunoglobulin M
vernacular_title: Morfologiia na slezkata i imunen otgovor pri eksperimentalen khranitelen nedoimuk u plukhov.