A new coagulation defect associated with a case of melanomatosis.
A marked abnormality of the intrinsic coagulation system was observed in a patient with melanomatosis and frank melanuria. With successful treatment of the tumour there was a parallel improvement in the clotting abnormality. This defect was shown to be a deficiency of factor XI together with a previously unrecognised factor. This is distinct from either Fletcher or Fitzgerald factors and appears to act between factors XI and X in the coagulation sequence.
D000328:Adult; D001778:Blood Coagulation Disorders / Q000209:etiology*; D005173:Factor XI Deficiency / Q000209:etiology*; D005260:Female; D006801:Humans; D008543:Melanins / Q000652:urine; D008545:Melanoma / Q000150:complications*; D011517:Prothrombin Time
D008543:Melanins