Effect of surfactants on absorption through membranes V: Concentration-dependent effect of a bile salt (sodium deoxycholate) on absorption of a poorly absorbable drug, phenolsulfonphthalein, in humans.
The effect of administration of 600-and 300-mg doses of sodium deoxycholate 1 hr before phenolsulfonphthalein solution is reported. The 600-mg dose caused a decrease in drug bioavailability as measured by the total amount excreted in 24 hr. The 300-mg dose cause and increase in the initial phenolsulfonphthalein absorption rate, suggesting a direct action of the bile salt on membrane permeability. The decrease in absorption upon administration of 600 mg was attributed to micellar entrapment of the drug molecule.
D000328:Adult; D001682:Biological Availability; D003840:Deoxycholic Acid / Q000008:administration & dosage / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D006801:Humans; D007408:Intestinal Absorption / Q000187:drug effects*; D008875:Middle Aged; D010635:Phenolphthaleins / Q000378:metabolism*; D010637:Phenolsulfonphthalein / Q000378:metabolism* / Q000652:urine; D013997:Time Factors
D010635:Phenolphthaleins; D003840:Deoxycholic Acid; D010637:Phenolsulfonphthalein