title: Intestinal responses to hyperosmolar glucose infusion in dogs.
abstract: Physiological and morphological changes of small intestine after hyperosmolar glucose infusions into canine jejunum were studied using in vivo perfusion model. Infusions of 40 ml of 50% and 20% glucose solution into the jejunal loops induced biphasic osmolar degression in the lumen. Osmolarity of jejunal venous blood was rapidly increased and maintained the maximal level (approximately 320 mOM/L). Blood flow to the jejunal loop was significantly increased after 50% glucose infusion compared to 5% glucose infusion. Most characteristic electron microscopic change of jejunal epithelial cell was pseudo-pod like process projected into the jejunal lumen, which was very similar to that of cholera.
mesh_terms: D000109:Acetylcholine / Q000494:pharmacology; D000818:Animals; D001285:Atropine / Q000494:pharmacology; D004285:Dogs; D005260:Female; D005947:Glucose / Q000008:administration & dosage / Q000494:pharmacology*; D007263:Infusions, Parenteral; D007419:Intestinal Secretions / Q000378:metabolism; D007583:Jejunum / Q000098:blood supply / Q000378:metabolism* / Q000648:ultrastructure; D008297:Male; D009994:Osmolar Concentration; D011188:Potassium / Q000378:metabolism; D012039:Regional Blood Flow / Q000187:drug effects; D012964:Sodium / Q000378:metabolism; D014680:Veins
chemical_list: D001285:Atropine; D012964:Sodium; D005947:Glucose; D000109:Acetylcholine; D011188:Potassium