Experimental hyphema clearance in rabbits. Drug trials with 1% atropine and 2% and 4% pilocarpine.
The effect of topical 1% atropine sulfate, 2% pilocarpine hydrochloride, and 4% pilocarpine hydrochloride on the clearance rate of RBCs labeled with chromium 51 (51Cr) that were injected into the anterior chamber of rabbits was determined by monitoring sequential radioactivity counts. Counts were made directly over the anterior chamber. One eye of each animal was treated with either 1% atropine, 2% pilocarpine, or 4% pilocarpine, and the other eye served as a control. None of these drugs significantly altered the clearance rate of 51Cr-labeled RBCs injected into the anterior chamber.
D000818:Animals; D001285:Atropine / Q000008:administration & dosage / Q000378:metabolism / Q000627:therapeutic use*; D002860:Chromium Radioisotopes; D006988:Hyphema / Q000188:drug therapy* / Q000378:metabolism; D010862:Pilocarpine / Q000008:administration & dosage / Q000378:metabolism / Q000627:therapeutic use*; D011817:Rabbits
D002860:Chromium Radioisotopes; D010862:Pilocarpine; D001285:Atropine