The effect of antibody on the migratory pattern of peritoneal macrophages.
51Cr-labeled peritoneal macrophages which interiorized sheep erythrocytes (SRBC) injected i.p. into syngeneic recipients accumulate in a typical fashion in different organs. The pattern of distribution can be altered by two maneuvers--when animals at the time of macrophages transfer are injected i.v. with cytophilic antibody, or when macrophages are fed with IgG-SRBC complexes instead of native SRBC. The possible role of modified migratory pattern of macrophages in antibody-induced suppression of the immune response is discussed.
D000818:Animals; D000906:Antibodies; D000936:Antigen-Antibody Complex; D000941:Antigens; D002465:Cell Movement; D004912:Erythrocytes / Q000276:immunology; D007111:Immunity, Cellular; D008264:Macrophages / Q000276:immunology*; D008297:Male; D051379:Mice; D008808:Mice, Inbred CBA; D010587:Phagocytosis
D000906:Antibodies; D000936:Antigen-Antibody Complex; D000941:Antigens