Oral infection of mice with trophozoites of Giardia muris.
Giardia muris has been maintained for years in the mouse by administering by gavage 10,000 trophozoites taken from the small intestine of infected mice. Despite the growth of numerous protozoa in the intestine, absorption of tetracycline hydrochloride in infected mice was not changed to a statistically significant extent, as blood drug levels increased only slightly: behavior was similarly unaffected. Reasons for the apparent lack of virulence of this strain are discussed.
D000284:Administration, Oral; D000818:Animals; D004195:Disease Models, Animal; D005872:Giardia / Q000472:pathogenicity*; D005873:Giardiasis / Q000209:etiology* / Q000378:metabolism; D007408:Intestinal Absorption; D051379:Mice; D013752:Tetracycline / Q000378:metabolism; D014774:Virulence
D013752:Tetracycline