title: Active site generated analogues of reactive intermediates in enzymic reactions. Potent inhibition of pyruvate dehydrogenase by a phosphonate analogue of pyruvate1.
mesh_terms: D001665:Binding Sites; D063065:Organophosphonates / Q000494:pharmacology; D009943:Organophosphorus Compounds / Q000494:pharmacology; D011768:Pyruvate Dehydrogenase Complex / Q000037:antagonists & inhibitors*; D011773:Pyruvates
chemical_list: D063065:Organophosphonates; D009943:Organophosphorus Compounds; D011768:Pyruvate Dehydrogenase Complex; D011773:Pyruvates