title: The in vitro frog pigment epithelial cell hyperpolarization in response to light.
abstract: Pigment epithelial cell membrane potentials were measured in an in vitro frog retina-pigment epithelium-choroid preparation. Light stimuli hyperpolarized the apical membrane of the pigment epithelium. This hyperpolarization was the source of the c-wave of the electroretinogram. Light stimuli also decreased retinal extracellular potassium ion concentration, [K+]O, with the same time course as the apical hyperpolarization. It is suggested that the pigment epithelial hyperpolarization, which causes the c-wave, results directly from the light-evoked decrease in retinal [K+]O.
mesh_terms: D000818:Animals; D001001:Anura; D004596:Electroretinography; D066298:In Vitro Techniques; D008027:Light; D008564:Membrane Potentials / Q000528:radiation effects; D010857:Pigment Epithelium of Eye / Q000528:radiation effects*; D011188:Potassium / Q000502:physiology
chemical_list: D011188:Potassium