Modification of the kinetic parameters of aldolase on binding to the actin-containing filaments of skeletal muscle.
The kinetic parameters of fructose bisphosphate aldolase (EC 4.1.2.13) were shown to be modified on binding of the enzyme to the actin-containing filaments of skeletal muscle. Although binding to F-actin or F-actin-tropomyosin filaments results in relative minor changes in kinetic properties, binding to F-actin-tropomyosin-troponin filaments produces major alterations in the kinetic parameters, and, in addition, renders them Ca2+-sensitive. These observations may be relevant to an understanding of the function of this enzyme within the muscle fibre.
D000199:Actins / Q000378:metabolism*; D000818:Animals; D002417:Cattle; D005634:Fructose-Bisphosphate Aldolase / Q000378:metabolism*; D007700:Kinetics; D009132:Muscles / Q000378:metabolism*; D011485:Protein Binding
D000199:Actins; D005634:Fructose-Bisphosphate Aldolase