title: [Intoxication with the pesticide IPO-1250 in rats].
abstract: Rats were administered porridge with pesticide IPO-1250 in doses 50, 200, 800 and 4000 ppm. The animals were killed and subjected to a selective examination. The mass of organs relative to the brain mass was determined and its segments were examined histopathologising. It has been concluded that IPO-1250 affect metabolic processes of rats, a decrease or increase of the inner organs mass. In the examined organs were observed non-specific and generally reversible pathomorphotic changes in the form of circulatory disturbances and regressive changes. The intensity of changes increased typically at the highest applied dose of pesticide = 4000 ppm. The observations allowed to establish the highest dose tolerated by rats which for the preparation IPO-1250 amounts to 800 ppm.
mesh_terms: D000818:Animals; D001562:Benzimidazoles / Q000008:administration & dosage / Q000633:toxicity*; D002219:Carbamates / Q000008:administration & dosage / Q000633:toxicity*; D005260:Female; D005659:Fungicides, Industrial / Q000008:administration & dosage / Q000633:toxicity*; D006321:Heart / Q000187:drug effects; D007668:Kidney / Q000187:drug effects; D008099:Liver / Q000187:drug effects; D008297:Male; D051381:Rats; D012737:Sex Factors; D013154:Spleen / Q000187:drug effects; D013997:Time Factors
chemical_list: D001562:Benzimidazoles; D002219:Carbamates; D005659:Fungicides, Industrial; C006698:carbendazim
vernacular_title: Skrócone zatrucie przewlekłe szczurów pestycydem IPO-1250