Rat intestinal and renal calcium-binding proteins.
The effect of vitamin D activity on the major renal Ca-binding protein has been compared with that on the intestinal Ca-binding protein. Using a method based on Ca-binding capacity, these proteins were measured in vitamin D deficient rats after vitamin D treatment for varying periods up to 5 days. Since P deficiency has been shown to stimulate synthesis of the active metabolite 1,25-dihydroxycholecalciferol, a similar experiment was done on rats fed a P-deficient diet for periods up to 21 days. The renal Ca-binding protein was unchanged by vitamin D treatment to vitamin D deficient rats and was only slightly increased (50%) by phosphate deficiency. By comparison, the intestinal protein was increased twofold by vitamin D treatment and fivefold by phosphate deficiency. Results indicate that vitamin D activity has no direct effect on the major renal Ca-binding protein.
D000818:Animals; D002118:Calcium / Q000378:metabolism*; D002352:Carrier Proteins / Q000378:metabolism*; D004032:Diet; D004386:Duodenum / Q000378:metabolism*; D005260:Female; D007668:Kidney / Q000378:metabolism*; D010710:Phosphates / Q000172:deficiency; D011485:Protein Binding; D051381:Rats; D014807:Vitamin D / Q000494:pharmacology; D014808:Vitamin D Deficiency / Q000378:metabolism
D002352:Carrier Proteins; D010710:Phosphates; D014807:Vitamin D; D002118:Calcium