Interactions of platinum complexes, peptides, methionine and dehydrogenases.
Eight platinum-methionine complexes have been investigated as inhibitors of the alcohol (EC 1.1.1.1) and lactate (EC 1.1.1.27) dehydrogenase systems. While only one complex, Pt(Met)Cl2, had two halogen ligands on the platinum, all the complexes were able to inhibit both enzyme systems. Of the various methionine and histidine containing peptides evaluated, the dipeptide Met-Met gave the best protection against inhibition by N-alkyl-substituted ethylenediamine-platinum complexes. The histidine containing peptides gave a slight protection against the inhibition by beta-[Pt(Met)(NH3)Cl]Cl. Thus it appears that in the enzyme systems studied, the methionine acts as a strong ligand for platinum.
D000429:Alcohol Oxidoreductases / Q000037:antagonists & inhibitors*; D001665:Binding Sites; D002945:Cisplatin / Q000494:pharmacology; D005029:Ethylenediamines / Q000494:pharmacology; D006639:Histidine; D007770:L-Lactate Dehydrogenase / Q000037:antagonists & inhibitors*; D008715:Methionine / Q000494:pharmacology*; D009842:Oligopeptides / Q000494:pharmacology*; D010984:Platinum / Q000494:pharmacology*
D005029:Ethylenediamines; D009842:Oligopeptides; D010984:Platinum; D006639:Histidine; D008715:Methionine; D000429:Alcohol Oxidoreductases; D007770:L-Lactate Dehydrogenase; D002945:Cisplatin