Synthesis and central nervous system evaluation of some 5-alkoxy-3H-1,4-benzodiazepin-2(1H)-ones.
A series of 1-R-5-alkoxy-3H-1,4-benzodiazepin-2(1H)-ones was prepared and evaluated for central nervous system depressant activity. Several of these compounds, in particular, 7-chloro-5-ethoxy-1-methyl-3H-1,4-benzodiazepin-2(1H)-one (2), gave a profile and activity level similar to diazepam when measured in mice.
D000662:Amphetamines / Q000494:pharmacology; D000818:Animals; D001463:Barbiturates / Q000494:pharmacology; D001522:Behavior, Animal / Q000187:drug effects*; D001570:Benzodiazepinones / Q000138:chemical synthesis* / Q000494:pharmacology / Q000633:toxicity; D003864:Depression, Chemical; D004347:Drug Interactions; D007928:Lethal Dose 50; D051379:Mice; D004856:Postural Balance / Q000187:drug effects
D000662:Amphetamines; D001463:Barbiturates; D001570:Benzodiazepinones