[Concerning the administration of pethidine (Dolantin during delivery: discussion to "Analgesia during delivery--delayed effects for the child? by Riegel, Messow and Pielsticker (author's transl)].
The obstetrical problematic of intrapartal infant death following administration of Dolantin were discussed with the help of both of the cases described in the article by Riegel et al. At the same time, the question of analgesia during delivery with pethidine in combination with a respiratory depressant antidote was examined. Lorfalgyl, according to current opinion, cannot compensate the antidepressive effect of pethidine. Instead, the application of pure pethidine is recommended for obstetric analgesia in the first stage of labor. Today, naloxone used as antidote is particularly suitable before delivery or can be injected into the umbilical vein of the child after delivery. A plan of treatment for pathidine therapy during the first stage of labor in combination with the antidepressant was suggested.
D000773:Anesthesia, Obstetrical / Q000009:adverse effects*; D001238:Asphyxia Neonatorum / Q000139:chemically induced*; D003864:Depression, Chemical; D005260:Female; D005318:Fetal Heart / Q000187:drug effects; D006801:Humans; D007231:Infant, Newborn; D008614:Meperidine / Q000008:administration & dosage / Q000009:adverse effects* / Q000494:pharmacology; D009270:Naloxone / Q000008:administration & dosage; D011247:Pregnancy; D012119:Respiration / Q000187:drug effects
D009270:Naloxone; D008614:Meperidine
Zur Anwendung von Pethidin (Dolantin) unter der Geburt (Diskussion zum Beitrag "Geburtsanalgesie--Spätwirkungen beim Kind?" von Riegel, Messow und Pielsticker).