Growth hormone release by gamma-aminobutyric acid (GABA) and gamma-amino-beta-hydroxybutyric acid (GABOB) in the rat.
Effects of gamma-aminobutyric acid (GABA) and gamma-amino-beta-hydroxybutyric acid (GABOB) on growth hormone (GH) release were investigated in the urethaneanesthetized male rat. An intraventricular injection of GABA and L-GABOB but not D-GABOB caused a significant increase in plasma GH. An intravenous injection of L-GABOB, at the dose which had no significant effect on basal plasma GH, remarkably enhanced plasma GH response to pentobarbital. These results suggest that GABA and L-GABOB stimulate GH release possibly via the central nervous system in the rat.
D000613:Aminobutyrates / Q000494:pharmacology*; D000818:Animals; D013006:Growth Hormone / Q000097:blood*; D006885:Hydroxybutyrates / Q000494:pharmacology*; D007275:Injections, Intravenous; D007276:Injections, Intraventricular; D008297:Male; D051381:Rats; D005680:gamma-Aminobutyric Acid / Q000494:pharmacology* / Q000031:analogs & derivatives
D000613:Aminobutyrates; D006885:Hydroxybutyrates; C004480:4-amino-3-hydroxybutyric acid; D005680:gamma-Aminobutyric Acid; D013006:Growth Hormone