title: Whole body protein synthesis and catabolism in septic man.
abstract: The protein catabolic response to sepsis has been measured in three patients and in two normal subjects using a pulse injections of L-[15N]alanine. In addition, the urea kinetics were measured using a pulse administration of [15N]urea. Several nitrogen models which simulated the metabolic pathways of nitrogen-labeled compounds were tried. Best curve fits and acceptable confidence limits were obtained with a four-pool model containing two metabolic pools and two urea pools. Using this model, synthesis and catabolism rates were calculated for a fast and slow protein turnover pool. The mean daily total protein synthesis rate in the normal was 3.695 g/kg compared to 4.479 g/kg in sepsis. Because all subjects were in negative nitrogen balance, the mean total protein catabolic rate in the normal was 4.379 g/kg, compared to 5.298 g/kg in sepsis. These data suggest an increase in both protein synthesis and catabolism during sepsis.
mesh_terms: D000038:Abscess / Q000378:metabolism; D000328:Adult; D005260:Female; D006801:Humans; D007081:Ileostomy; D007239:Infections / Q000378:metabolism*; D007410:Intestinal Diseases / Q000378:metabolism; D007412:Intestinal Fistula; D007700:Kinetics; D008297:Male; D008954:Models, Biological; D010537:Peritoneum; D010538:Peritonitis / Q000378:metabolism; D014176:Protein Biosynthesis; D011506:Proteins / Q000378:metabolism*; D014947:Wounds and Injuries / Q000378:metabolism
chemical_list: D011506:Proteins