title: Sickle cell anemia and trait in a population of southern India.
abstract: In an ethnic group in southern India, the Irula, seven individuals with sickle cell anemia were found to manifest only mild illness. Although a relatively high level of fetal hemoglobin was present in one, none of the factors thought to ameliorate the course of sickling disorders could be identified in the remaining six. In a random population survey, sickle hemoglobin was found in 90 of 292 Irula (31%). In those with sickle cell trait, the proportion of sickle hemoglobin in hemolysates (mean = 26%, range 19-32%) was substantially lower than that reported for any other population.
mesh_terms: D000755:Anemia, Sickle Cell / Q000097:blood / Q000453:epidemiology*; D006451:Hemoglobin, Sickle / Q000032:analysis; D006801:Humans; D007194:India; D012805:Sickle Cell Trait / Q000453:epidemiology
chemical_list: D006451:Hemoglobin, Sickle