[Clinical-chemical studies in schizophrenic out-patients under neuroleptic long-term treatment with particular consideration of the hepatic metabolism (author's transl)].
A series of clinical-chemical tests was conducted in 68 schizophrenic out-patients under long-term neuroleptic medication, with particular consideration of the hepatic metabolism, i.e.: Erythrocyte sedimentation rate, alpha 1-glycoprotein, ceruloplasmin, fibrinogen, GPT, GOT, gamma-GT, total protein and serum-protein-electrophoresis. Furthermore, the glucose tolerance tests was carried out. In 44% of the patients an increased erythrocyte sedimentation rate and positive correlations with increased fibrinogen values were found. Increased gamma-GT-values were proven in 33% of the patients; they correlated positively with the increased GPT-and/or GOT-values as well as with pathological glucose tolerance values. Overweight of more than 10 kilos was found in 46% of the patients. A significant correlation between overweight and pathological glucose tolerance values existed. The results were interpreted as consequence of a light fatty liver.
D000328:Adult; D000368:Aged; D001798:Blood Proteins / Q000378:metabolism; D002570:Ceruloplasmin / Q000378:metabolism; D005260:Female; D005340:Fibrinogen / Q000378:metabolism; D006023:Glycoproteins / Q000097:blood; D006801:Humans; D008099:Liver / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D012559:Schizophrenia / Q000097:blood / Q000188:drug therapy*; D013997:Time Factors; D014149:Tranquilizing Agents / Q000097:blood / Q000494:pharmacology* / Q000627:therapeutic use; D000637:Transaminases / Q000097:blood
D001798:Blood Proteins; D006023:Glycoproteins; D014149:Tranquilizing Agents; D005340:Fibrinogen; D002570:Ceruloplasmin; D000637:Transaminases
Laborklinische Untersuchungen unter besonderer Berücksichtigung des Leberstoffwechsels bei Schizophrenen unter ambulanter neuroleptischer Langzeitmedikation.