Origin in tobacco smoke of N'-nitrosonornicotine, a tobacco-specific carcinogen.
To evaluate risk factors and to approach methods of reduction of the carcinogenic potential of cigarette smoke, the transfer rate of N-nitrosonornicotine in a popular U.S. blended cigarette into mainstream smoke was quantitatively determined. The mean transfer rate was 11.3%; thus approximately 46% of the tobacco-specific carcinogen in the smoke came from the tobacco, and the remainder was synthesized during smoking.
D009538:Nicotine / Q000031:analogs & derivatives* / Q000138:chemical synthesis; D009602:Nitrosamines / Q000138:chemical synthesis; D010947:Plants, Toxic; D012907:Smoking; D014026:Nicotiana
D009602:Nitrosamines; D009538:Nicotine; C008655:N'-nitrosonornicotine