title: Hypothalamic self-stimulation and operant activity in the mottled mutant mouse.
abstract: Some behavioural effects of the mottled mutation were studied in the variegated heterozygote female. In mutants, compared to normals, operant activity was increased, whereas hypothalamic self-stimulation was always decreased. These results are discussed relative to the excepted central catecholaminergic disturbances resulting from the mutant gene.
mesh_terms: D000818:Animals; D003216:Conditioning, Operant / Q000502:physiology*; D004056:Differential Threshold; D004299:Dopamine beta-Hydroxylase / Q000172:deficiency*; D005260:Female; D007031:Hypothalamus / Q000502:physiology*; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains / Q000502:physiology; D012640:Seizures / Q000235:genetics; D012653:Self Stimulation / Q000502:physiology*
chemical_list: D004299:Dopamine beta-Hydroxylase