[Research on heterocyclic compounds. VI. Imidazo(1,2-b)pyridazine derivatives].
The preparation of a group of imidazo[1,2-b]pyridazin-2-carboxylic and -2-acetic acids is reported. The ethyl esters of these acids were prepared by reaction of some 3-aminopyridazines with ethyl bromopyruvate or 4-bromoacetoacetate. The acids were obtained by hydrolysis of the corresponding esters, and their anti-inflammatory activity was tested.
D000085:Acetates / Q000138:chemical synthesis; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000138:chemical synthesis; D002264:Carboxylic Acids / Q000138:chemical synthesis; D006868:Hydrolysis; D011724:Pyridazines / Q000138:chemical synthesis*; D051381:Rats; D012106:Research
D000085:Acetates; D000893:Anti-Inflammatory Agents; D002264:Carboxylic Acids; D011724:Pyridazines
Ricerche su composti eterociclici. VI. Derivati imidazo[1,2-b]piridazinici.