Gastric responses to flupenthixol, a new thioxanthene derivative in rats.
Flupenthixol, a new thioxanthene derivative, was studied for its effects on gastric secretion and gastric ulcers in rats. The compound diminished the volume of gastric secretion, decreased total acid output and protected the glandular gastric mucosa. The observations may be of clinical significance.
D000818:Animals; D003864:Depression, Chemical; D005260:Female; D005475:Flupenthixol / Q000494:pharmacology* / Q000627:therapeutic use; D005750:Gastric Juice / Q000378:metabolism*; D008297:Male; D051381:Rats; D013276:Stomach Ulcer / Q000517:prevention & control*; D013892:Thioxanthenes / Q000494:pharmacology*
D013892:Thioxanthenes; D005475:Flupenthixol