A modified leucocyte migration assay as indicator of malignant and non-malignant gastric mucosal alteration.
When gastric cancer patients' leucocytes were exposed to a panel of tumour extracts, leucocyte migration reactivity was "positive" before operation (90% of cases), it declined after surgery and it reappeared in patients with local recurrence or metastases. In patients with non-malignant gastric diseases, "positive" reactivity against tumour extracts was associated almost exclusively with atrophic gastritis with and without intestinal metaplasia (24/43 cases). "Positive" patients also showed a pathological migration index with an extract of normal gastric mucosa.
D000328:Adult; D000368:Aged; D000951:Antigens, Neoplasm; D005500:Follow-Up Studies; D005753:Gastric Mucosa / Q000276:immunology / Q000473:pathology*; D005756:Gastritis / Q000175:diagnosis / Q000276:immunology*; D006801:Humans; D007962:Leukocytes / Q000276:immunology*; D008875:Middle Aged; D009362:Neoplasm Metastasis; D010437:Peptic Ulcer / Q000175:diagnosis / Q000276:immunology; D013274:Stomach Neoplasms / Q000175:diagnosis / Q000276:immunology* / Q000601:surgery; D014020:Tissue Extracts
D000951:Antigens, Neoplasm; D014020:Tissue Extracts