[Effect of hydrocortisone on DNA synthesis by urinary bladder epithelial cells and renal cortical substance and on the concentration of glucocorticoids in the blood].
Single administration of hydrocortisone (10 mg per 100 g of body weight) led at first to increase, and then to statistically significant reduction of the peripheral blood plasma corticosteroid level in rats. An increase of glucocorticosteroids was accompanied by a reduction in number of DNA-synthesizing cells of the urinary bladder epithelium leading later to the fall in the number of mitoses, whereas reduction of the hormone--to increase of the cell change from G1 to S period. At the same time inhibition of the proliferative processes in the kidney epithelium lasted during the whole experiment (48 hours). Possible causes of different sensitivity of the epithelial tissues to hydrocortisone are discussed.
D000818:Animals; D004247:DNA / Q000096:biosynthesis*; D004848:Epithelium; D005938:Glucocorticoids / Q000097:blood*; D006854:Hydrocortisone / Q000494:pharmacology*; D007672:Kidney Cortex / Q000187:drug effects* / Q000378:metabolism; D008297:Male; D008938:Mitosis / Q000187:drug effects; D051381:Rats; D001743:Urinary Bladder / Q000187:drug effects* / Q000378:metabolism
D005938:Glucocorticoids; D004247:DNA; D006854:Hydrocortisone
Deĭstvie gidrokortizona na sintez DNK kletok épiteliia mochevogo puzyria i korkovogo veshchestva pochki i na soderzhanie gliukokortikoidov v krovi.