title: Proteolytic, antigenic and immunogenic properties of Schistosoma mansoni cercarial secretion material.
abstract: Schistosoma mansoni cercariae secrete preacetabular gland material in association with skin penetration. The material is heterogeneous and contains proteolytic enzyme(s) which comprise a small proportion of the total protein. We have immunized mice with cercarial secretion material in several protocols designed to induce a variety of antibody responses. The cercarial secretion material is sufficiently immunogenic to induce precipitating and reaginic antibody production. The antibodies obtained were not of the necessary quantity and/or quality to afford protection from a challenge infection.
mesh_terms: D000818:Animals; D000917:Antibody Formation; D000941:Antigens / Q000032:analysis; D002241:Carbohydrates / Q000032:analysis; D002850:Chromatography, Gel; D004591:Electrophoresis, Polyacrylamide Gel; D005612:Freeze Drying; D007114:Immunization; D007525:Isoelectric Focusing; D051379:Mice; D010447:Peptide Hydrolases / Q000032:analysis; D011506:Proteins / Q000032:analysis; D012550:Schistosoma mansoni / Q000201:enzymology / Q000276:immunology*
chemical_list: D000941:Antigens; D002241:Carbohydrates; D011506:Proteins; D010447:Peptide Hydrolases