Diffusion of antibiotics from acrylic bone-cement in vitro.
The diffusion of Fucidin, gentamicin, and clindamycin from acrylic cement was tested in an in vitro system. The activity of Fucidin was very short-lived and only against gram-positive organisms; gentamicin inhibited gram-positive and gram-negative organisms for twenty-two and eleven days respectively; clindamycin had significant action only against gram-positive organisms and retained some activity for fifty-six days. We suggest that the destruction of organisms in the tissues is more likely to be achieved by topical and intravenous administration of antibiotics during the operation than by incorporation of antibiotic in the cement.
D000180:Acrylic Resins; D001419:Bacteria / Q000187:drug effects; D001702:Biopharmaceutics; D001843:Bone Cements; D002981:Clindamycin / Q000008:administration & dosage / Q000494:pharmacology*; D003692:Delayed-Action Preparations; D005672:Fusidic Acid / Q000008:administration & dosage / Q000494:pharmacology*; D005839:Gentamicins / Q000008:administration & dosage / Q000494:pharmacology*; D006621:Hip Joint / Q000601:surgery; D006801:Humans; D066298:In Vitro Techniques; D008826:Microbial Sensitivity Tests; D013530:Surgical Wound Infection / Q000517:prevention & control
D000180:Acrylic Resins; D001843:Bone Cements; D003692:Delayed-Action Preparations; D005839:Gentamicins; D002981:Clindamycin; D005672:Fusidic Acid