Vitamin E enhancement of Venezuelan equine encephalomyelitis antibody response in guinea pigs.
Immune response potentiation by vitamin E was studied in guinea pigs with Venezuelan equine encephalomyelitis attenuated live-virus vaccine as the antigenic stimulus; antibodies were measured by the hemagglutination-inhibition (HI) test. Significantly higher (P less than 0.01) HI antibody titers resulted when guinea pigs were given intramuscular injections of dl-alpha-tocopherol, 33 IU/kg of body weight, before and after immunization. The HI antibody titers to Venezuelan equine encephalomyelitis virus were not increased when guinea pigs were given dl-alpha-tocopheryl acetate orally. This is the first report on vitamin E humoral immune response enhancement to an attenuated live-virus vaccine.
D000818:Animals; D000914:Antibodies, Viral; D000917:Antibody Formation / Q000187:drug effects*; D004666:Encephalitis Virus, Venezuelan Equine / Q000276:immunology*; D005260:Female; D006168:Guinea Pigs; D007074:Immunoglobulin G / Q000032:analysis; D007249:Inflammation; D007273:Injections, Intramuscular; D008297:Male; D014611:Vaccination; D014810:Vitamin E / Q000008:administration & dosage / Q000009:adverse effects / Q000494:pharmacology*
D000914:Antibodies, Viral; D007074:Immunoglobulin G; D014810:Vitamin E