title: [C-peptide: secretion and metabolism in different functional states and with abnormal B-cell function (author's transl)].
abstract: Fasting C-peptide levels and those after tolbutamide or glucose stimulation were measured in normal subjects. In patients with various hypo- or hyper-functions of the endocrine pancreas, C-peptide levels were compared with the corresponding insulin levels. In insulin-dependent maturity-onset diabetics there were both normal and elevated serum C-peptide levels. In juvenile diabetics and patients with total duodenopancreatectomy there was no measureable C-peptide. It is concluded that the half-life of C-peptide is three times that of insulin.
mesh_terms: D002096:C-Peptide / Q000097:blood / Q000378:metabolism*; D003920:Diabetes Mellitus / Q000378:metabolism; D003922:Diabetes Mellitus, Type 1 / Q000378:metabolism; D005947:Glucose; D006207:Half-Life; D006801:Humans; D007328:Insulin / Q000097:blood; D010180:Pancreatectomy; D010455:Peptides / Q000378:metabolism*; D014044:Tolbutamide
chemical_list: D002096:C-Peptide; D007328:Insulin; D010455:Peptides; D014044:Tolbutamide; D005947:Glucose
vernacular_title: C-Peptid. Sekretion und Stoffwechsel bei unterschiedlichen Funktionszustäden und Störungen der B-Zellen der Langerhansschen Inseln.