title: Lost mass and excretion as stimuli to parabiotic compensatory renal hypertrophy.
abstract: To help determine the roles of lost renal mass and lost excretory ability in producing renoprival hypertrophy, observations were made in otherwise normal rats cross-circulated for 24 h with rats prepared in one of the following ways: bilateral nephrectomy, bilateral ureteral ligation, or bilateral nephrectomy with 24 h of uremia. Bilateral nephrectomy produced parabiotic increases in renal mass and in the average cellular concentration of RNA: bilateral ureteral ligation did not. Uremia did not potentiate the effects of bilateral nephrectomy. Lost mass is the determinant of compensatory renal hypertrophy.
mesh_terms: D000818:Animals; D006984:Hypertrophy; D007668:Kidney / Q000502:physiology*; D008297:Male; D009392:Nephrectomy; D010227:Parabiosis; D051381:Rats; D014511:Uremia / Q000150:complications