title: Prognostic significance of thrombocytosis in idiopathic sideroblastic anemia.
abstract: In order to determine the prognostic significance of thrombocytosis in idiopathic sideroblastic anemia, the clinical courses of 17 patients were reviewed. Six patients (36%) had thrombocytosis, and none developed acute leukemia. Nine patients (53%) had normal platelet counts, and one developed acute leukemia. Two patients (12%) were thrombocytopenic, and one died of acute leukemia. There was little correlation between survival and platelet count. Sixty-three additional case reports of idiopathic sideroblastic anemia were collected from the literature. Analysis of those patients and the patients in the present study documented transformation to acute leukemia in 5 of 9 (56%) thrombocytopenic patients, 4 of 54 (7.4%) patients with normal platelet counts, and 0 of 17 patients with thrombocytosis (p less than 0.05). Therefore patients with idiopathic sideroblastic anemia and thrombocytosis appear to have a decreased likelihood of leukemic transformation.
mesh_terms: D000368:Aged; D000756:Anemia, Sideroblastic / Q000150:complications* / Q000188:drug therapy; D002471:Cell Transformation, Neoplastic; D004351:Drug Resistance; D005260:Female; D006801:Humans; D007938:Leukemia / Q000175:diagnosis*; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D011736:Pyridoxine / Q000627:therapeutic use; D013922:Thrombocytosis / Q000150:complications*
chemical_list: D011736:Pyridoxine