Relationship between pulmonary embolism, airway obstruction and hypersensitivity of the airways in dogs: influence of partial vagus nerve blockade.
Experiments in dogs showed an increase in deltaPoes/100 ml TV after embolization which returns to normal after blocking the vagus nerves, indicating an increase in airway resistance. A marked sensitization to ACh inhalation by embolism with both blood clots and glass beads was demonstrated. This hypersensitivity is vagus-dependent.
D000109:Acetylcholine / Q000009:adverse effects; D000402:Airway Obstruction / Q000503:physiopathology*; D000403:Airway Resistance / Q000187:drug effects; D000818:Animals; D001784:Blood Gas Analysis; D004285:Dogs; D004342:Drug Hypersensitivity / Q000503:physiopathology; D005260:Female; D006439:Hemodynamics / Q000187:drug effects; D008297:Male; D011343:Procaine / Q000008:administration & dosage; D011655:Pulmonary Embolism / Q000209:etiology / Q000503:physiopathology*; D012129:Respiratory Function Tests; D012130:Respiratory Hypersensitivity / Q000503:physiopathology*; D014630:Vagus Nerve / Q000187:drug effects* / Q000503:physiopathology
D011343:Procaine; D000109:Acetylcholine