title: Effects of monoamine oxidase inhibitors on the borohydride stabilizable binding of serotonin and tryptamine in brain.
abstract: The in vivo and in vitro effects of various monoamine oxidase inhibitors (MAOI) on the borohydride stabilizable finding of serotonin (5-HT) or tryptamine in brain was investigated. A significant correlation between the extent of Mao inhibition and the amount of stabilized binding of the indolealkylamines was demonstrated. All hydrazine-type MAOI and harmine, a reversible nonhydrazine-type MAOI, employed in vitro, were shown to decrease the binding. beta-Phenylisopropylhydrazine apparently blocks the receptor carbonyl groups in the brain in vitro as well as in vivo.
mesh_terms: D000818:Animals; D001665:Binding Sites / Q000187:drug effects; D001894:Borohydrides / Q000494:pharmacology*; D001921:Brain / Q000378:metabolism*; D066298:In Vitro Techniques; D051379:Mice; D008995:Monoamine Oxidase / Q000378:metabolism; D008996:Monoamine Oxidase Inhibitors / Q000494:pharmacology*; D012701:Serotonin / Q000378:metabolism*; D014363:Tryptamines / Q000378:metabolism*
chemical_list: D001894:Borohydrides; D008996:Monoamine Oxidase Inhibitors; D014363:Tryptamines; D012701:Serotonin; D008995:Monoamine Oxidase