[Retinoblastoma and transmission of balanced chromosomal modifications].
Two cases of retinoblastoma in two children showing a chromosomal rearrangement in the karyotype  were reported. In the first case, a pericentric inversion of chromosome 9 was observed both in the child and his father. In the second case, a reciprocal translocation t (3;12)(q29;q15) present also in the paternal karyotype was identified. A strict connection cannot be established between the tumour itself and the family chromosomal aberrations, but these observations raise the problem of a possible "interchromosomal effect".
D000328:Adult; D002869:Chromosome Aberrations; D007446:Chromosome Inversion; D002906:Chromosomes, Human, 6-12 and X; D005134:Eye Neoplasms / Q000235:genetics* / Q000601:surgery; D005260:Female; D006801:Humans; D007223:Infant; D007621:Karyotyping; D008297:Male; D013508:Ophthalmologic Surgical Procedures; D012175:Retinoblastoma / Q000235:genetics* / Q000601:surgery; D014178:Translocation, Genetic
Rétinoblastome et transmission de remaniements chromosomiques balancés.