Genetic control of contact sensitivity to oxazolone in inbred, H-2 congenic and intra-H-2 recombinant strains of mice.
Delayed-type hypersensitivity (DTH) to 2-phenyl-4-ethoxymethylene-5-oxazolone (oxazolone) was found to be under multigenic control in inbred, H-2 congenic and intra-H-2 recombinant strains of mice. A high response was associated with haplotypes H-2d,a,k and low response with haplotype H-2b. DTH to oxazolone was high or intermediate in different F1 hybrids of high and low responder mice. In F2 and backcross generations a higher response was associated with the "dd", than with "bb" phenotype, while intermediate response was found in the heterozygote "db" mice. A study of H-2 recombinant strains suggests that a gene controlling the DTH response maps in the I-B subregion of the H-2 complex. The response was significantly modified by gene(s) which are not linked to the H-2 complex and have not been mapped. Since congenitally athymic nude (nu/nu) mice did not respond to oxazolone, this contact sensitivity is belived to be a T cell-dependent immune response.
D000287:Administration, Topical; D000483:Alleles; D000818:Animals; D003877:Dermatitis, Contact / Q000235:genetics*; D005796:Genes; D008040:Genetic Linkage; D006648:Histocompatibility; D007111:Immunity, Cellular; D051379:Mice; D008815:Mice, Inbred Strains; D010080:Oxazoles / Q000276:immunology*; D010081:Oxazolone / Q000008:administration & dosage / Q000276:immunology*; D010641:Phenotype; D013045:Species Specificity
D010080:Oxazoles; D010081:Oxazolone