The direct effects of circulating lidocaine on uterine blood flow and foetal well-being in the pregnant ewe.
We infused lidocaine intravenously into 13 pregnant ewes at a rate sufficient to maintain plasma levels between 2-4 mugm/ml, which are those commonly seen with regional anaesthesia. These levels did not change maternal blood pressure, pulse rate, cardiac output, stroke volume, total peripheral resistance, uterine blood flow or intra-amniotic pressure. Foetal blood pressure and pulse rate remained stable as did both maternal and foetal blood gases and acid-base values.
D000818:Animals; D005260:Female; D005333:Fetus / Q000187:drug effects* / Q000502:physiology; D006439:Hemodynamics / Q000187:drug effects; D008012:Lidocaine / Q000097:blood / Q000494:pharmacology*; D008431:Maternal-Fetal Exchange; D011247:Pregnancy; D012039:Regional Blood Flow / Q000187:drug effects; D012756:Sheep; D013997:Time Factors; D014599:Uterus / Q000098:blood supply*
D008012:Lidocaine