[Repression and derepression of lactate dehydrogenase loci during mouse development].
The ultramicroelectrophoretic method was applied to the study of the lactic dehydrogenase (LDH) spectrum alterations during the developmental phases of mice: ovulated ova--zygote--blastocyte--embryo--oocyte--ovulated ova. Only H-subunits were found in the embryo cells before the 5th day of development. After this M-subunits appeared indicating derepression of LDH-A locus. On the 8th day of the embryonal development deres pression of the LDH-B locus was observed to disappear during the oogenesis, being the result of progressive repression of locus LDH-A. Dictiotena of meios prophase is characterised by active H-subunit synthesis and a gradual decrease of the M-subunit synthesis. During the whole dictiotena phase the LDH-spectrum of the follicular cells was of the M-type.
D000818:Animals; D002874:Chromosome Mapping; D004622:Embryo, Mammalian / Q000201:enzymology*; D004794:Enzyme Repression; D005260:Female; D007527:Isoenzymes; D007770:L-Lactate Dehydrogenase / Q000378:metabolism*; D051379:Mice; D009865:Oocytes / Q000201:enzymology*; D010063:Ovum / Q000201:enzymology*; D011247:Pregnancy
D007527:Isoenzymes; D007770:L-Lactate Dehydrogenase
Repressiia i derepressiia lokusov laktatdegidrogenazy v protsesse razvitiia myshi.