[Importance of heparin in thrombin-131I clearance and in the complex formation processes in animals under experimental restoration of the function of the anticoagulating system].
Thrombine-I131 infusion to animals receiving Linethol with vitamin A in the presence of both natural and atherogenic diets accelerated the clearance of thrombine-I131 and elevated the level of nonenzymatic fibrinolysis in the blood and tissue of the liver and lungs. In addition to the administration of thrombine-I131, intravenous heparin injections to animals kept for a long time on atherogenic diets and receiving Linethol with vitamin A provided for a still greater acceleration of thrombine-I131 clearance, which manifested itself in its faster absorption from blood by the liver in the form of a thrombine-I131 -- heparin complex, in an increasing total fibrinolytic activity and of its nonenzymatic fibrinolysis in blood plasma and tissues of the liver and lungs. This resulted in a partial restoration of the function of the anticoagulation system and an increase of the functional activity of the hepatic tissue directed at the consumption of the thrombine excess from the blood flow.
D000818:Animals; D004036:Diet, Atherogenic; D004347:Drug Interactions; D005231:Fatty Acids, Unsaturated / Q000378:metabolism; D005342:Fibrinolysis / Q000187:drug effects; D006493:Heparin / Q000378:metabolism*; D007457:Iodine Radioisotopes; D008099:Liver / Q000503:physiopathology; D008168:Lung / Q000503:physiopathology; D008297:Male; D008657:Metabolic Clearance Rate; D051381:Rats; D013154:Spleen / Q000503:physiopathology; D013917:Thrombin / Q000378:metabolism*; D013997:Time Factors; D014801:Vitamin A / Q000378:metabolism
D005231:Fatty Acids, Unsaturated; D007457:Iodine Radioisotopes; C014642:linethol; D014801:Vitamin A; D006493:Heparin; D013917:Thrombin
Znachenie geparina v klirense trombina-131I i protsessakh kompleksoobrazovaniia u zhivotnykh v usloviiakh éksperimental'nogo vosstanovleniia funktsii protivosvertyvaiushcheĭ sistemy