Effect of growth factors on hepatic drug metabolism in diabetic-hypophysectomized rats.
In vivo administration to diabetic-hypothysectomized rats of either the growth factor produced by the plerocercoid larvae of the tapeworm, Spirometra mansonoides, or mammalian growth hormone caused inhibition of hepatic drug metabolism measured in vitro.
D000632:Aminopyrine / Q000378:metabolism; D000814:Aniline Compounds / Q000378:metabolism; D000818:Animals; D002589:Cestoda; D003921:Diabetes Mellitus, Experimental / Q000378:metabolism*; D013006:Growth Hormone / Q000494:pharmacology*; D006133:Growth Substances / Q000494:pharmacology*; D007016:Hypophysectomy; D008099:Liver / Q000378:metabolism*; D008297:Male; D010902:Pituitary Gland / Q000502:physiology*; D051381:Rats
D000814:Aniline Compounds; D006133:Growth Substances; D000632:Aminopyrine; D013006:Growth Hormone