Clomid or nafoxidine administered to neonatal rats causes reproductive tract abnormalities.
A single injection of either Clomid or Nafoxidine in neonatal rats causes multiple abnormalities of the reproductive tract of the adult female animal. These anomalies include cystic ovaries, ovarian hypoplasia, hilus cell tumors, oviductal hyperplasia, pyometra, epithelial metaplasia, uterine cystic hyperplasia, and tumors of the uterus.
D000367:Age Factors; D000818:Animals; D000831:Animals, Newborn; D002996:Clomiphene / Q000633:toxicity*; D004305:Dose-Response Relationship, Drug; D005260:Female; D005836:Genitalia, Female / Q000187:drug effects*; D009256:Nafoxidine / Q000633:toxicity*; D010053:Ovary / Q000187:drug effects; D011759:Pyrrolidines / Q000633:toxicity*; D051381:Rats; D014594:Uterine Neoplasms / Q000139:chemically induced; D014599:Uterus / Q000187:drug effects
D011759:Pyrrolidines; D002996:Clomiphene; D009256:Nafoxidine