Initiation of human parturition. VIII. Metabolism of progesterone by fetal membranes of early and late human gestation.
A decreased rate of progesterone metabolism is detected in human fetal membranes several weeks preceding normal parturition at term. A 10- to 20-fold decrease in 20alpha-hydroxysteroid oxidoreductase activity and a 2- to 6-fold decrease in 5alpha-reductase activity are observed in human amnion and chorion laeve after 33 weeks' gestation.
D005321:Extraembryonic Membranes / Q000378:metabolism*; D005260:Female; D005865:Gestational Age; D006801:Humans; D007745:Labor Onset; D011247:Pregnancy; D011276:Pregnanediol / Q000378:metabolism; D011280:Pregnanolone / Q000378:metabolism; D011284:Pregnenolone / Q000378:metabolism; D011374:Progesterone / Q000378:metabolism*
D011374:Progesterone; D011284:Pregnenolone; D011280:Pregnanolone; D011276:Pregnanediol