Stimulation of prostaglandin output from rat stomach by hypertonic solutions.
A whole-cell preparation of rat stomach put out appreciable amounts of immunoassayable PGE. Buffers made hypertonic with either sodium chloride or mannitol effected several-fold increases in PGE output, while a comparable osmotic concentration of urea seemed to produce much less stimulation. Enhancement of PGE output by saline--hypertonic buffers was concentration-dependent. It is suggested that the osmolarity of the gastric contents may play a role in regulating gastric PG biosynthesis.
D000818:Animals; D005260:Female; D005753:Gastric Mucosa / Q000378:metabolism*; D006982:Hypertonic Solutions / Q000494:pharmacology*; D066298:In Vitro Techniques; D008353:Mannitol / Q000494:pharmacology; D011458:Prostaglandins E / Q000378:metabolism*; D051381:Rats; D012965:Sodium Chloride / Q000494:pharmacology; D013268:Stimulation, Chemical; D013270:Stomach / Q000187:drug effects; D013997:Time Factors; D014508:Urea / Q000494:pharmacology
D006982:Hypertonic Solutions; D011458:Prostaglandins E; D008353:Mannitol; D012965:Sodium Chloride; D014508:Urea