title: [Study of the destruction of the sympathetic ganglia by the administration of guanethidine to newborn rats and mice].
abstract: Following the injection of guanethidine (25 mg/kg) to rats from the first day of life during 2 weeks, over 70% of sympathic neurons in the stellate ganglion die. If the injections are carried out during 4 weeks, over 99% of neurons die. The injection of guanethidine to mice during 5 weeks did not result in the destruction of nerve elements in the ganglion, as compared with the control.
mesh_terms: D000818:Animals; D000831:Animals, Newborn / Q000254:growth & development*; D003714:Denervation; D005725:Ganglia, Autonomic / Q000187:drug effects*; D006145:Guanethidine / Q000494:pharmacology*; D007279:Injections, Subcutaneous; D051379:Mice; D009474:Neurons / Q000187:drug effects; D051381:Rats; D013233:Stellate Ganglion / Q000187:drug effects; D013997:Time Factors
chemical_list: D006145:Guanethidine
vernacular_title: Issledovanie destruktsii simpaticheskikh gangliev pri vvedenii guanetidina novorozhdennym krysam i mysham.