Long-term studies on chemically induced liver enlargement in the rat. II. Transient induction of microsomal enzymes leading to liver damage and nodular hyperplasia produced by safrole and Ponceau MX.
D000818:Animals; D001391:Azo Compounds / Q000494:pharmacology*; D056486:Chemical and Drug Induced Liver Injury; D004032:Diet; D004149:Dioxoles / Q000494:pharmacology*; D004790:Enzyme Induction / Q000187:drug effects; D005260:Female; D005505:Food Coloring Agents / Q000494:pharmacology*; D006651:Histocytochemistry; D006965:Hyperplasia / Q000139:chemically induced; D008099:Liver / Q000187:drug effects / Q000473:pathology / Q000648:ultrastructure; D008107:Liver Diseases / Q000473:pathology; D008862:Microsomes, Liver / Q000201:enzymology*; D009282:Naphthalenesulfonates / Q000494:pharmacology*; D009929:Organ Size / Q000187:drug effects; D051381:Rats; D012451:Safrole / Q000494:pharmacology*; D013997:Time Factors
D001391:Azo Compounds; D004149:Dioxoles; D005505:Food Coloring Agents; D009282:Naphthalenesulfonates; D012451:Safrole; C015476:ponceau MX