Liquid chromatography in pharmaceutical analysis VII: determination of dantrolene sodium in biological fluids.
Dantrolene sodium can be determined in plasma and urine samples by high-pressure liquid chromatography without interference from its two major metabolites, the hydroxy and acetamido compounds. The minimum detectability of the drug using this procedure is 8 ng. The complete assay including extraction, evaporation, and separation steps can be performed in approximately 70 min with an accuracy of 1--3%.
D001773:Blood Cells / Q000378:metabolism; D002851:Chromatography, High Pressure Liquid; D003620:Dantrolene / Q000032:analysis* / Q000097:blood / Q000652:urine; D006801:Humans; D006827:Hydantoins / Q000032:analysis*; D008722:Methods; D013050:Spectrometry, Fluorescence
D006827:Hydantoins; D003620:Dantrolene