alpha-Tocopherylquinone: effect on blood pressure in normotensive volunteers and its plasma concentrations in men and dogs.
Three normotensive volunteers were given oral doses of alpha-tocopherylquinone. Blood pressure and its plasma concentrations were measured before and within 6 hours after taking this drug. Two dogs were given alpha-tocopherylquinone orally and after 3 days intravenously. Plasma concentrations were measured after each administration. Our result showed that this drug did not affect the blood pressure of normotensive individuals, and only small concentrations of alpha-tocopherylquinone were detected in plasma. In dogs, oral doses gave higher plasma levels than intravenous administration.
D000328:Adult; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects*; D004285:Dogs; D006801:Humans; D007700:Kinetics; D008297:Male; D011809:Quinones / Q000097:blood / Q000494:pharmacology; D013997:Time Factors; D014810:Vitamin E / Q000097:blood / Q000494:pharmacology*
D011809:Quinones; D014810:Vitamin E