The reversibility of the inhibition of intestinal amino-acid transport by harmaline.
The inhibitory aciton of harmaline on L-phenylalanine uptake by guinea-pig intestinal rings is fully reversible provided only low concentrations of the inhibitor are used; if the concentration is raised to a sufficient extent to enable the drug to interfere with sodium pumping or cellular metabolic reactions, as witnessed by its effect on tissue oxygen consumption, then the inhibition of L-phenylalanine uptake is only reversible if short contact times are employed.
D000470:Alkaloids / Q000494:pharmacology*; D000818:Animals; D001692:Biological Transport / Q000187:drug effects; D001834:Body Water / Q000378:metabolism; D003864:Depression, Chemical; D006168:Guinea Pigs; D006246:Harmaline / Q000494:pharmacology*; D007082:Ileum / Q000187:drug effects / Q000378:metabolism*; D066298:In Vitro Techniques; D010101:Oxygen Consumption / Q000187:drug effects; D010649:Phenylalanine / Q000378:metabolism*
D000470:Alkaloids; D010649:Phenylalanine; D006246:Harmaline