title: [Pre-seasonal treatment of hayfever with a pollen depot extract (author's transl)].
abstract: 90 patients with "hayfever" - that means pollenallergic diseases of the respiration tract and the eyes - were treated in spring 1974 and 1975 with a tyrosinabsorbed grass and rye depot extract with three injections before the pollen-season. Only 16 patients had an isolated grass-rye-pollen-allergy in skin test, all the other patients had additional extrinsic allergies. These results were proved by RAST. One third of the patients had bad side-effects (27 out of 90) during the treatment. 17 patients showed general reactions and ten patients very strong local reactions. We think that these side-effects were caused by contact with antigens (hairs of animals, foods, flowers of trees) during therapy and acute or chronic infections. The results of therapy were asked by a questionnaire one year after the series of injections, there were 37 improved, 32 unchanged and/or worsened in pollen-season after treatment. Nevertheless the results encouraged to continue this treatment with the grass-rye-pollen-extract. It could be used as an "initial treatment" in pollinosis patients with a wide spread allergy just before the beginning of the pollen-season. It is necessary to fullfill all procedures of precaution which are in use in hyposensitizationtherapy to prevent stronger side-effects.
mesh_terms: D000328:Adult; D003888:Desensitization, Immunologic / Q000009:adverse effects; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D010936:Plant Extracts / Q000627:therapeutic use*; D006109:Poaceae; D011058:Pollen; D006255:Rhinitis, Allergic, Seasonal / Q000175:diagnosis / Q000188:drug therapy*; D012621:Seasons; D012882:Skin Tests; D013997:Time Factors; D014443:Tyrosine / Q000627:therapeutic use
chemical_list: D010936:Plant Extracts; D014443:Tyrosine
vernacular_title: Zur präsaisonalen Behandlung des Heuschnupfens mit einem Depot-Pollenextrakt (L-Tyrosin-Adsorbat).