Epidural melanoma causing posterior paresis in a horse.
An aged gray stallion was examined because of fullminating posterior paresis, bladder paralysis, and perineal anesthesia. Lower motor neuron dysfunction was detected at the lumbosacral level of the spinal cord, and cerebrospinal fluid was yellow. After brief supportive treatment, the horse died. Necropsy revealed a single epidural melanoma at L5-6. The absence of cutaneous melanotic growth, absence of organ involvement, and extensive vertebral remodeling indicated the neoplasm to have been primary and to have been present for an extended period. Neurologic dysfunction was acute and progressive, as a result of spinal cord compression by the neoplasm.
D000818:Animals; D006734:Horse Diseases / Q000473:pathology; D006736:Horses; D008159:Lumbar Vertebrae; D008297:Male; D008545:Melanoma / Q000150:complications / Q000473:pathology / Q000662:veterinary*; D010243:Paralysis / Q000209:etiology / Q000473:pathology / Q000662:veterinary*; D013125:Spinal Neoplasms / Q000150:complications / Q000473:pathology / Q000662:veterinary*