Structure of a molluscan cardioexcitatory neuropeptide.
A cardioexcitatory substance from ganglia of the clam Macrocallista nimbosa, formerly designated peak C, is the tetrapeptide amide Phe-Met-Arg-Phe-NH2. Its structure was determined by the combined use of Edman dansyl degradation and tryptic digestion. The structure was confirmed by synthesis. This neuropeptide is active at about 10(-8)M when assayed on molluscan muscle.
D000595:Amino Acid Sequence; D000818:Animals; D049872:Bivalvia / Q000032:analysis*; D005724:Ganglia / Q000032:analysis; D006321:Heart / Q000187:drug effects*; D009119:Muscle Contraction / Q000187:drug effects; D009419:Nerve Tissue Proteins / Q000302:isolation & purification / Q000494:pharmacology; D009842:Oligopeptides / Q000302:isolation & purification / Q000494:pharmacology; D013329:Structure-Activity Relationship
D009419:Nerve Tissue Proteins; D009842:Oligopeptides