A family study of a patient with idiopathic hemochromatosis.
A family study of a patient with idiopathic hemochromatosis using noninvasive techniques is presented. All 6 of the patient's asymptomatic children had an increase in transferrin saturation and/or an increase in the absorption of Co57. The Co57 absorption test was the most sensitive index of family involvement since one of the children had an increase in absorption at a time when transferring saturation was normal. The family data strongly support the hereditary nature of the disorder, with the mode of inheritance not clearly established from the available data.
D003037:Cobalt Radioisotopes; D003676:Deferoxamine / Q000378:metabolism; D006432:Hemochromatosis / Q000097:blood / Q000235:genetics*; D006801:Humans; D007501:Iron / Q000097:blood / Q000652:urine; D008297:Male; D008875:Middle Aged; D014556:Urine / Q000378:metabolism
D003037:Cobalt Radioisotopes; D007501:Iron; D003676:Deferoxamine