Clinical significance of specific IgE antibody against streptokinase-streptodornase in renal diseases of childhood.
The immediate skin reaction (IR) with streptokinase-streptodornase (SK-SD) was found with a high incidence in children with renal disease and was confirmed to be mediated by a specific IgE antibody against SK-SD by means of the radioallergosorbent test (RAST). This test revealed high radiocounts in children with renal disease who showed the IR and there was a close correlation between the RAST counts and the intensity of the IR. Furthermore, the RAST counts in the severe nephrotic syndrome belonging to corticosteroid dependent and resistant group were far higher than those in the corticosteroid sensitive group. From these results, a determination of the RAST counts against SK-SD seemed to help evaluate the severity of some nephrotic syndromes and the specific IgE antibody may be involved in the pathogenesis of the disease.
D000305:Adrenal Cortex Hormones / Q000378:metabolism; D000918:Antibody Specificity; D002648:Child; D005260:Female; D005921:Glomerulonephritis / Q000276:immunology; D006801:Humans; D006969:Hypersensitivity, Immediate; D007073:Immunoglobulin E / Q000032:analysis; D007428:Intradermal Tests; D007674:Kidney Diseases / Q000276:immunology* / Q000378:metabolism; D008297:Male; D009404:Nephrotic Syndrome / Q000276:immunology*; D011507:Proteinuria / Q000276:immunology; D011852:Radioallergosorbent Test; D013299:Streptodornase and Streptokinase / Q000276:immunology*
D000305:Adrenal Cortex Hormones; D007073:Immunoglobulin E; D013299:Streptodornase and Streptokinase