[Effect of cyanocobalamin, cobamide coenzyme and the cytostatic hispen on changes in cobalamin levels in healthy rats and rats with transplanted sarcoma M-1].
The influence of cyanocobalamine (CN-B12), cobamide coenzyme (5'-deoxyadenosyl-B12, DBC) and the cytostatic hisphen on the level of cobalamines in the blood serum, liver, kidney, heart and in the tumor of healthy and sarcoma M-1 implanted rats was studied. In the above organs and tissues cobalamines were found to occur in the free and protein-bound state (cobalamine-protein complexes). The complexes were of different stability. The ratio of free to protein-bound cobalamines varied. The content of cobalamine-protein complexes in healthy and tumorous tissues was different. CN-B12, DBC and hisphen influenced specifically the redistribution of cobalamine and protein-bound complexes.
D000818:Animals; D003038:Cobamides / Q000627:therapeutic use*; D006639:Histidine / Q000031:analogs & derivatives / Q000627:therapeutic use; D007668:Kidney / Q000378:metabolism; D008099:Liver / Q000378:metabolism; D008297:Male; D009206:Myocardium / Q000378:metabolism; D009368:Neoplasm Transplantation; D009588:Nitrogen Mustard Compounds / Q000627:therapeutic use*; D051381:Rats; D012513:Sarcoma, Experimental / Q000188:drug therapy* / Q000378:metabolism; D014805:Vitamin B 12 / Q000378:metabolism / Q000627:therapeutic use*
D003038:Cobamides; D009588:Nitrogen Mustard Compounds; C009759:hisphen; D006639:Histidine; D014805:Vitamin B 12
Vliianie tsiankobalamina, kobamidnogo kofermenta i tsitostatika gisfena na izmenenie urovnia kobalaminov u zdorovykh krys i krys s privitoĭ sarkomoĭ M-1