Increased incorporation of fatty acids into phospholipids of lungs and livers of rabbits under the influence of bromhexine and ambroxol.
The incorporation of lauric acid, palmitic acid and oleic acid into phospholipids of lung and liver has been studied in tissue slices of control rabbits and of rabbits treated with bromhexine or ambroxol in doses of 10 mg/kg. A marked increase (up to 200% of the controls) of palmitic acid incorporation into phosphatidylcholine (lecithin) and phosphatidylethanolamine of the lung was found whereas the incorporation rate of palmitic acid into lecithin and phosphatidylethanolamine of the liver displayed no significant change. The incorporation of lauric acid and oleic acid into lung phospholipids was not accelerated. The observed effects were more marked in short time experiments (analysis 2 h after drug injection) than after treatements for 7 days. It is concluded that the phospholipid synthesis is stimulated by the drugs especially in the lungs. This seems to be of particular interest with respect to the surfactant system of the lung and might have some therapeutic relevance.
D000551:Ambroxol / Q000494:pharmacology*; D000818:Animals; D001964:Bromhexine / Q000031:analogs & derivatives* / Q000494:pharmacology*; D004247:DNA / Q000378:metabolism; D005227:Fatty Acids / Q000378:metabolism*; D005260:Female; D008099:Liver / Q000187:drug effects / Q000378:metabolism*; D008168:Lung / Q000187:drug effects / Q000378:metabolism*; D008297:Male; D010743:Phospholipids / Q000096:biosynthesis*; D011817:Rabbits; D013268:Stimulation, Chemical; D013997:Time Factors
D005227:Fatty Acids; D010743:Phospholipids; D000551:Ambroxol; D004247:DNA; D001964:Bromhexine