Electron capture gas chromatography detection and mass spectrum identification of 3-(2'-ketohexyl)indoline in spinal fluids of patients with tuberculous meningitis.
A basic, extractable, indolic type of compound, which was derivatized with heptafluorobutyric anhydride and pyridine, was obtained from the cerebrospinal fluids of patients with acute tuberculous meningitis. The compound was detected by frequency-pulsed, modulated electron capture gas-liquid chromatography, and it was tentatively identified by mass spectrometry as 3-(2'-ketohexyl)indoline. The compound was found to be valuable for differentiating between tuberculous, cryptococcal, and aseptic meningitides.
D055598:Chemical Phenomena; D002621:Chemistry; D002849:Chromatography, Gas; D003453:Cryptococcosis / Q000175:diagnosis; D003937:Diagnosis, Differential; D006588:Hexanones / Q000134:cerebrospinal fluid; D006801:Humans; D007211:Indoles / Q000134:cerebrospinal fluid*; D013058:Mass Spectrometry; D008581:Meningitis / Q000175:diagnosis; D014390:Tuberculosis, Meningeal / Q000134:cerebrospinal fluid* / Q000175:diagnosis
C015312:3-(2'-ketohexyl)indoline; D006588:Hexanones; D007211:Indoles