Effects of Ag+ on frog skin: interactions with oxytocin, amiloride and ouabain.
Different biological effects of Ag+ (10(-4) M) were found depending on its presence in the outer or the inner solution bathing the frog skin. A marked increase in the electrical conductance and an interference with the action of oxytocin and amiloride were found only when Ag+ was added to the outer solution. Results suggest that Ag+ affects several transport processes, in particular the permeability of the Na entry pathways.
D000584:Amiloride / Q000494:pharmacology*; D000818:Animals; D001001:Anura; D001693:Biological Transport, Active; D004553:Electric Conductivity; D010042:Ouabain / Q000494:pharmacology*; D010121:Oxytocin / Q000494:pharmacology*; D010539:Permeability; D011719:Pyrazines / Q000494:pharmacology*; D011898:Ranidae; D012834:Silver / Q000494:pharmacology*; D012867:Skin / Q000187:drug effects; D012879:Skin Physiological Phenomena; D012964:Sodium / Q000378:metabolism
D011719:Pyrazines; D012834:Silver; D010121:Oxytocin; D010042:Ouabain; D000584:Amiloride; D012964:Sodium