The use of sodium nitroprusside in children.
The hypotensive response to sodium nitroprusside was investigated in 30 children, age range 5-15 years, weight range 14-60 kg, who were undergoing spinal surgery for kyphoscoliosis. It was possible to achieve a constant level of satisfactory hypotension within the range 70-80 mmHg systolic arterial pressure using sodium nitroprusside infused at a rate of 10 microng/kg/minute and no serious side effects were experienced at this dose rate.
D000293:Adolescent; D001794:Blood Pressure / Q000187:drug effects; D002648:Child; D002675:Child, Preschool; D004305:Dose-Response Relationship, Drug; D005292:Ferricyanides / Q000494:pharmacology; D006470:Hemorrhage; D006801:Humans; D007023:Hypotension, Controlled; D009599:Nitroprusside / Q000494:pharmacology; D013997:Time Factors
D005292:Ferricyanides; D009599:Nitroprusside