Kidney in the aging cat: neutral lipid and adenyl cyclase histochemistry.
Neutral lipid and adenyl cyclase were evaluated to determine their concentrations in the kidney of the aging cat. Kidneys from 24 domestic cats 2 months to 7.5 years old in 6 age groups were examined by light microscopic and histochemical methods. Activity in anatomic components of the kidney was assessed on a quantitative basis for evaluation of mean activity between the age groups. Renal components generally were stable in activity in the cats with advancing age. A significant increase in lipid concentration occurred in the convoluted segments of the proximal tubules with advancing age. In contrast, the straight segments of the proximal tubules displayed a significant decrease in lipid concentration with aging. Significant increases in adenyl cyclase activity were evident with aging in the ascending thick limb of Henle's loop and distal tubules.
D000262:Adenylyl Cyclases / Q000378:metabolism*; D000375:Aging; D000818:Animals; D002415:Cats / Q000378:metabolism*; D005260:Female; D007668:Kidney / Q000378:metabolism*; D007678:Kidney Glomerulus / Q000378:metabolism; D007686:Kidney Tubules, Distal / Q000378:metabolism; D007687:Kidney Tubules, Proximal / Q000378:metabolism; D050356:Lipid Metabolism; D008138:Loop of Henle / Q000378:metabolism; D008297:Male
D000262:Adenylyl Cyclases