Reduction of bovine pulmonary hypertension by normoxia, verapamil and hexoprenaline.
In calves with hypoxic pulmonary hypertension, resistance was reduced by 40 +/- 3% with normoxia, 19 +/- 4% with verapamil, and 60 +/- 1% with hexoprenaline. It is possible that the increased resistance during normoxia is due to partly to vasoconstriction rather than solely to vascular thickening, and that the vasoconstriction is due to an abnormality in calcium metabolism by the hypertensive vasculature.
D000403:Airway Resistance / Q000187:drug effects; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D002118:Calcium / Q000502:physiology; D002417:Cattle; D006594:Hexoprenaline / Q000494:pharmacology / Q000627:therapeutic use*; D006976:Hypertension, Pulmonary / Q000188:drug therapy* / Q000209:etiology / Q000503:physiopathology; D000860:Hypoxia / Q000150:complications; D010100:Oxygen / Q000627:therapeutic use; D010627:Phenethylamines / Q000627:therapeutic use*; D014655:Vascular Resistance / Q000187:drug effects; D014700:Verapamil / Q000494:pharmacology / Q000627:therapeutic use*
D010627:Phenethylamines; D014700:Verapamil; D006594:Hexoprenaline; D010100:Oxygen; D002118:Calcium