Hypocholesterolaemia in the rat after p-chlorophenoxyisobutyric acid (CPIB) administration as a synthetic triglyceride, 1,3-dipalmitoyl 2(p-chlorophenoxyisobutyroyl)-rac-glycerol.
A synthetic triglyceride analogue, 1,3-dipalmitoyl 2(p-chlorophenoxyisobutyroyl)-rac-glycerol, was fed to rats and its effect compared to that of clofibrate. Both compounds significantly lowered plasma cholesterol concentration and the decreases essentially paralleled each other, even when the dose of drug or the period of administration was varied. No consistent effect was noted on the plasma triglyceride concentration. The results suggest that synthetic lipids are potentially suitable carriers for the oral administration of pharmacologically active agents.
D000818:Animals; D000924:Anticholesteremic Agents; D001835:Body Weight / Q000187:drug effects; D002784:Cholesterol / Q000097:blood; D002994:Clofibrate / Q000031:analogs & derivatives* / Q000494:pharmacology; D050356:Lipid Metabolism; D008055:Lipids / Q000097:blood; D008099:Liver / Q000378:metabolism; D008297:Male; D009929:Organ Size / Q000187:drug effects; D051381:Rats; D013997:Time Factors; D014280:Triglycerides / Q000494:pharmacology
D000924:Anticholesteremic Agents; D008055:Lipids; D014280:Triglycerides; D002784:Cholesterol; D002994:Clofibrate