The pharmacology of prostaglandin-like substances released from guinea-pig lungs during anaphylaxis.
The pharmacology of the prostaglandins (PGs) and thromboxanes (Txs) released from immunologically challenged guinea-pig lungs is related to their roles in the anaphylactic response. 6-oxo-PGF1alpha probably contibutes substantially to bronchoconstriction during anaphylaxis. TxB2 may contribute to the anaphylactic response by increasing SRA-A release and by stimulating leucotaxis. The 15-oxo metabolites of PGE2 and PGF2alpha are rather weak spasmogens, but might modify respiratory muscle contractions and pulmonary vascular resistance. The 15-oxo 13,14 dihydro metabolites of PGE2 PGF2alpha and TxB2 were inactive in the systems studied, suggesting an important inactivating role for the 13:14 reductase enzyme.
D000707:Anaphylaxis / Q000378:metabolism*; D000818:Animals; D002633:Chemotaxis / Q000187:drug effects; D005849:Gerbillinae; D006168:Guinea Pigs; D006880:Hydroxy Acids / Q000302:isolation & purification / Q000494:pharmacology; D066298:In Vitro Techniques; D007962:Leukocytes / Q000187:drug effects; D008168:Lung / Q000187:drug effects / Q000276:immunology / Q000378:metabolism*; D008297:Male; D051379:Mice; D009119:Muscle Contraction / Q000187:drug effects*; D009130:Muscle, Smooth / Q000187:drug effects; D011453:Prostaglandins / Q000302:isolation & purification / Q000494:pharmacology*; D011458:Prostaglandins E / Q000494:pharmacology; D011460:Prostaglandins F / Q000494:pharmacology; D011714:Pyrans / Q000302:isolation & purification / Q000494:pharmacology; D051381:Rats; D014655:Vascular Resistance / Q000187:drug effects
D006880:Hydroxy Acids; D011453:Prostaglandins; D011458:Prostaglandins E; D011460:Prostaglandins F; D011714:Pyrans