The effect of fluorocitrate on urinary calcium and citrate excretion.
The renal handling of calcium and citrate was studied in dogs after the administration of fluorocitrate. The drug produced a significant increase in urinary calcium and citrate excretion. Net renal secretion of citrate occurred during the infusion of fluorocitrate since citrate clearances exceeded the glomerular filtration rate.
D000138:Acidosis / Q000652:urine; D000471:Alkalosis / Q000652:urine; D000818:Animals; D002118:Calcium / Q000097:blood / Q000652:urine*; D002951:Citrates / Q000097:blood / Q000494:pharmacology* / Q000652:urine*; D004285:Dogs; D005260:Female; D005919:Glomerular Filtration Rate; D007668:Kidney / Q000378:metabolism*
D002951:Citrates; D002118:Calcium