Response of influenza virus-infected mice to selected doses of ribavirin administered intraperitoneally or by aerosol.
The effects of graded doses of ribavirin administered either by aerosol or intraperitoneally were compared in influenza virus-infected mice. The median effective dose values (based upon percent survival) were 3.3 and 15.8 mg/kg per day for the aerosol and intraperitoneal routes, respectively. Lung lesion scores and titer of virus were lower after aerosol than intraperitoneal therapy.
D000336:Aerosols; D000818:Animals; D009980:Influenza A virus; D007274:Injections, Intraperitoneal; D051379:Mice; D009976:Orthomyxoviridae Infections / Q000188:drug therapy*; D012254:Ribavirin / Q000008:administration & dosage* / Q000627:therapeutic use; D012263:Ribonucleosides / Q000008:administration & dosage*
D000336:Aerosols; D012263:Ribonucleosides; D012254:Ribavirin