Effect of sodium ortho-iodobenzoate on oxygen transport and erythropoiesis in hypoxemic dogs with a right-to-left cardiac shunt.
Eight dogs were made hypoxemic by surgical construction of a right-to-left cardiac shunt; and they were given sodium ortho-iodobenzoate (OISB) before and for 3 months after operation. The P(50) at 50% saturation) rose from 27.2 +/- 0.7 to 31.2 +/- 0.6 mm Hg (p less than 0.001) during OLSB treatment before operation and increased further to 32.2 +/- 0.8 mm Hg 3 months after creation of hypoxemia. The P(50) remained elevated for an additional 3 months after OISB was stopped. Administration of OISB before operation did not alter the red blood cell 2,3-diphosphoglycreate concentration. Hypoxemia caused an increase of this metabolite from 0.91 +/- 0.21 to 1.50 +/- 0.28 moles/moles of hemoglobin (p less than 0.05); the rise was not as great as that observed in hypoxemic dogs without OISB treatment. In spite of significant hypoxemia, hematocrit rose only slightly during the period of OISB infusion. OISB increased P50 and prevented the compensatory polycythemia regularly seen when dogs are made hypoxemic. Altering oxygen transport in this fashion may increase tissue oxygen delivery in patients with conditions which result in tissue hypoxia.
D000818:Animals; D001158:Arteries / Q000637:transplantation; D002245:Carbon Dioxide / Q000097:blood; D004163:Diphosphoglyceric Acids / Q000097:blood; D004285:Dogs; D004920:Erythropoiesis; D006325:Heart Atria / Q000601:surgery; D000860:Hypoxia / Q000503:physiopathology*; D007463:Iodobenzoates / Q000494:pharmacology*; D007773:Lactates / Q000097:blood; D008722:Methods; D010100:Oxygen / Q000097:blood*; D010108:Oxyhemoglobins / Q000032:analysis; D011773:Pyruvates / Q000097:blood; D014184:Transplantation, Homologous; D014682:Vena Cava, Inferior / Q000601:surgery
D004163:Diphosphoglyceric Acids; D007463:Iodobenzoates; D007773:Lactates; D010108:Oxyhemoglobins; D011773:Pyruvates; D002245:Carbon Dioxide; D010100:Oxygen