title: Arterial oxygenation differences with carbon dioxide-induced versus voluntary increases in minute ventilation in chronic airway obstruction.
abstract: Two groups of patients with similar degrees of chronic airway obstruction exhibited different degrees of increased arterial oxygenation with CO2-induced hyperpnea versus voluntary increases in ventilation matched for ventilatory pattern. Patients who failed to increase arterial PO2 as much with voluntary hyperventilation as with CO2 challenge also had a lower dynamic compliance with the voluntary maneuver, whereas those with similar increases in arterial PO2 had similar dynamic compliances during the 2 periods of increased minute ventilation. The differences between the 2 groups are believed to be related to different effects of hypocapnia on collateral ventilation.
mesh_terms: D000402:Airway Obstruction / Q000097:blood*; D001991:Bronchitis / Q000097:blood; D002908:Chronic Disease; D006801:Humans; D006935:Hypercapnia / Q000097:blood*; D006985:Hyperventilation / Q000097:blood*; D007545:Isoproterenol / Q000008:administration & dosage; D008170:Lung Compliance / Q000187:drug effects; D008176:Lung Volume Measurements; D010100:Oxygen / Q000097:blood*; D011656:Pulmonary Emphysema / Q000097:blood
chemical_list: D007545:Isoproterenol; D010100:Oxygen