Bilateral absence of the kidneys and ureters. Three cases reported in one family.
Three infant boys with bilateral absence of the kidneys and hypoplasia of the lungs are described. Two of the infants were brothers and the third was a first cousin. They were born to 2 sisters whose husbancs were unrelated to their wives and to each other. None of the parents had renal problems. The occurrence of this syndrome in 2 male sibs is suggestive of an autosomal recessive inheritance pattern which has been previously described. An additional male first cousin born to the mother's sister is sugesstive of sex-linked inheritance for this particular family, an inheritance pattern not previously described.
D000015:Abnormalities, Multiple / Q000235:genetics*; D005808:Genes, Recessive; D006801:Humans; D007231:Infant, Newborn; D007668:Kidney / Q000002:abnormalities*; D008168:Lung / Q000002:abnormalities; D008297:Male; D010375:Pedigree; D012730:Sex Chromosomes; D014513:Ureter / Q000002:abnormalities*