The relative ability of four rubella antigens to elicit blast cell transformation of lymphocytes from immune individuals.
The ability of crude, semi-purified, and purified rubella antigens to elicit a specific and significant blast cell transformation of lymphocytes from immune individuals was investigated in 25 seronegative and 25 seropositive young adults. The type of preparation and the purity of the antigens were critical. Titration of the antigens by complement fixation or hemagglutination was of little value for selecting the best antigen which was a whole virion-purified antigen.
D000328:Adult; D000956:Antigens, Viral / Q000032:analysis / Q000302:isolation & purification; D004306:Dose-Response Relationship, Immunologic; D005260:Female; D006801:Humans; D037102:Lectins / Q000494:pharmacology; D008213:Lymphocyte Activation; D008214:Lymphocytes / Q000276:immunology; D008297:Male; D008934:Mitogens; D012412:Rubella virus / Q000276:immunology*
D000956:Antigens, Viral; D037102:Lectins; D008934:Mitogens