Effect of vincristine on glucose-induced insulin secretion in man.
60 min after the injection of therapeutic doses of vincristine for cancer chemotherapy, there is a reduction of the total (40%) and of the acute phase (43%) areas of insulin secretion inductedby 5-g i.v glucose load, and the constant of gllcose utilization is reduced by 25%. No differences are observed after 3 5-g i.v. glucose loads given at hourly intervals in control subjects.
D001786:Blood Glucose / Q000378:metabolism; D005260:Female; D005947:Glucose; D006801:Humans; D007328:Insulin / Q000378:metabolism*; D000078790:Insulin Secretion; D007700:Kinetics; D008297:Male; D009369:Neoplasms / Q000097:blood* / Q000188:drug therapy; D014750:Vincristine / Q000627:therapeutic use
D001786:Blood Glucose; D007328:Insulin; D014750:Vincristine; D005947:Glucose