[Combination chemotherapy of experimental leukemia].
In the present work an attempt was made to gain greater therapeutic effect of diazane coupled with adriamycin and sarcolysin. Leucemias L-1210 and La served as a model. In leucosis La diazane was injected once in 5 days. Either an additional injection of adriamycin two days prior to diazane injection or sarcolysin injected simultaneously with diazane enabled the authors to obtain a distinct synergestic effect. In leucemia L-1210 a simultaneous administration of diazane and sarcolysin also contributes to considerably longer survival of leucemic animals. Such combinations are likely to be promising in their clinical use.
D000818:Animals; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D001391:Azo Compounds / Q000008:administration & dosage / Q000627:therapeutic use*; D004317:Doxorubicin / Q000008:administration & dosage / Q000627:therapeutic use; D004359:Drug Therapy, Combination; D007939:Leukemia L1210 / Q000188:drug therapy; D007942:Leukemia, Experimental / Q000188:drug therapy*; D008558:Melphalan / Q000008:administration & dosage / Q000627:therapeutic use; D051379:Mice; D013386:Succinates / Q000008:administration & dosage / Q000627:therapeutic use
D000970:Antineoplastic Agents; D001391:Azo Compounds; D013386:Succinates; D004317:Doxorubicin; D008558:Melphalan
Kombinirovannaia khimioterapiia eksperimental'nykh leĭkozov.