The absolute configuration of SU 23397: a novel neuroleptic agent.
The absolute configuration of a novel chiral neuroleptic agent SU 23397 (I) was determined by ORD comparison of (+)-5-methoxy dihydro coumarilic acid (VIII), a synthetic precursor of SU 23397 (I), with (+)-dihydro coumarilic acid, whose absolute configuration is known. This assignment was confirmed by oxidative degradation of (+)-5-methoxy dihydro coumarilic acid VIII to D-(+)-malic acid.
D001572:Benzofurans / Q000138:chemical synthesis; D008968:Molecular Conformation; D009904:Optical Rotation; D013141:Spiro Compounds / Q000138:chemical synthesis; D014149:Tranquilizing Agents / Q000138:chemical synthesis
D001572:Benzofurans; D013141:Spiro Compounds; D014149:Tranquilizing Agents; C010829:8((2,3-dihydro-5-methoxy-2-benzofuranyl)- methyl)-1-phenyl-1,3,8-triazospiro(4,5)decan-4-one