Substance P and 5-HT in granules isolated from an intestinal argentaffin carcinoid.
Intestinal argentaffin carcinoids, thought to originate from enterochromaffin cells, occasionally contain large amounts of substance P-like immunoreactivity in addition to 5-HT. The cytoplasmic granules of one such tumour were isolated. The granules, which in the electron microscope were shown to be argentaffin, contained both substance P-like immunoreactivity and 5-HT. The results support the view that substance P is localized in a population of enterochromaffin cells where it is stored in the cytoplasmic granules together with 5-HT.
D000328:Adult; D002276:Carcinoid Tumor / Q000378:metabolism* / Q000473:pathology; D006801:Humans; D007414:Intestinal Neoplasms / Q000378:metabolism* / Q000473:pathology; D008297:Male; D008854:Microscopy, Electron; D012701:Serotonin / Q000378:metabolism*; D013373:Substance P / Q000378:metabolism*
D012701:Serotonin; D013373:Substance P