Pharmacokinetic study of netilmicin.
Netilmicin at a dose of 2 mg/kg was infused intravenously into 10 healthy volunteers. A peak serum concentration of 16.56 mug/ml was obtained at the end of the infusion. Thirty-nine percent of the infused dose was excreted in the urine during the first 8 h after infusion. The pharmacokinetic parameters of netilmicin were derived by analyzing the elimination data according to a two-compartment model.
D000328:Adult; D000900:Anti-Bacterial Agents / Q000378:metabolism*; D005260:Female; D006801:Humans; D007700:Kinetics; D008297:Male; D008875:Middle Aged; D012853:Sisomicin / Q000031:analogs & derivatives / Q000097:blood / Q000378:metabolism*
D000900:Anti-Bacterial Agents; D012853:Sisomicin