title: [Haptoglobin and ceruloplasmin in systemic scleroderma].
abstract: Content of haptoglobin and ceruloplasmin was estimated in blood serum of 23 patients with sclerodermia systematica. A statistically distinct decrease in ceruloplasmin concentration was observed in blood of the patients, whereas content of haptoglobin was markedly increased; this phenomenon reflects a level of the pathological process activity. The proteins are synthesized in various zones of liver lobes: haptoglobin--in the central zone, ceruloplasmin - in the peripheral one. Decrease in content of ceruloplasmin in blood of patients with sclerodermia systematica was due to impairment of hepatocytes, localized in peripheral parts of liver lobes.
mesh_terms: D000818:Animals; D002252:Carbon Tetrachloride Poisoning / Q000097:blood; D002570:Ceruloplasmin / Q000032:analysis*; D056486:Chemical and Drug Induced Liver Injury / Q000097:blood; D006242:Haptoglobins / Q000032:analysis*; D006801:Humans; D011817:Rabbits; D012595:Scleroderma, Systemic / Q000097:blood*
chemical_list: D006242:Haptoglobins; D002570:Ceruloplasmin
vernacular_title: Gaptoglobin i tseruloplazmin pri sistemnoĭ sklerodermii.