[2 possible mechanisms of action of thyroxine on mitochondrial swelling].
The effect of thyroxin on different types of mitochondrial swelling (induced by calcium, detergents, valinomycine, or lipid peroxidation) was investigated. Under conditions favourable for phospholipase-induced mitochondrial swelling on account of phospholipase activation (low Mg2+ concentration, and Ca2+ present in the incubation medium) the hormone proved to accelerate the swelling of the organellae. When phospholipase-induced mechanism of mitochondrial swelling was inhibited (high Mg2+ concentration) thyroxin depressed considerably the swelling of organellae induced by lipid peroxidation due to its antioxidant action.
D000818:Animals; D002118:Calcium / Q000494:pharmacology; D003840:Deoxycholic Acid / Q000494:pharmacology; D004347:Drug Interactions; D008274:Magnesium / Q000494:pharmacology; D008930:Mitochondria, Liver / Q000187:drug effects; D008933:Mitochondrial Swelling / Q000187:drug effects*; D051381:Rats; D013974:Thyroxine / Q000494:pharmacology*; D014634:Valinomycin / Q000494:pharmacology
D003840:Deoxycholic Acid; D014634:Valinomycin; D008274:Magnesium; D013974:Thyroxine; D002118:Calcium
Dva vozmozhnykh mekhanizma deĭstviia tiroksina na nabukhanie mitokhondriĭ.