Sudden deafness: histopathologic correlation in temporal bone.
The histopathological study of two cases of sudden deafness is presented. The temporal bones showed cochleosaccular abnormality. The most striking pathological changes were collapse of the organ of Corti, atrophy of the tectorial membrane, atrophy of the stria vascularis, decrease in the number of the cochlear nerves, collapse of the saccular membrane and partial absence of the sensory epithelial layer in the saccular macula. These changes are quite similar in type to those occurring in labyrinthitis of known viral etiology and to those in previously reported cases of sudden deafness which were assumed to be of viral origin. This evidence suggests that a viral infection was the most probable etiology of sudden deafness in these ears. In addition, unusual findings of endolymphatic hydrops limited to the extreme basal end of the cochlear duct were found in Case 1. A patent cochlear aqueduct and circumscribed perilymphatic labyrinthine ossification in  the superior seimicircular canal were also observed. With these histopathological findings, the possibility of viral infection via the meninges as well as via the hematogenous route into the inner ear is proposed.
D003051:Cochlea / Q000473:pathology*; D003638:Deafness / Q000209:etiology / Q000473:pathology*; D006801:Humans; D007759:Labyrinth Diseases / Q000150:complications; D007761:Labyrinthine Fluids; D008297:Male; D008875:Middle Aged; D009925:Organ of Corti / Q000473:pathology; D013701:Temporal Bone / Q000473:pathology*