[Action of the microbial flora of the digestive tract on the biosynthesis of cholic acid in the rat (author's transl)].
Axenic and holoxenic (conventional) rats were fed a diet containing trace amounts of [2,4-3H]cholic and [24-14C]chemodeoxycholic acids. In the feces of both groups of rats, the percentage of labelled bile acids which were 3H-labelled was slightly different. In the experimental conditions used, the intestinal microflora only slightly modified the synthesis of 12alpha-hydroxylated bile acids.
D000818:Animals; D001647:Bile Acids and Salts / Q000378:metabolism; D002793:Cholic Acids / Q000096:biosynthesis*; D005856:Germ-Free Life; D007413:Intestinal Mucosa / Q000378:metabolism; D007422:Intestines / Q000382:microbiology*; D008297:Male; D051381:Rats
D001647:Bile Acids and Salts; D002793:Cholic Acids
Action de la flore microbienne du tractus digestif sur la biosynthèse de l'acide cholique chez le rat.