title: Evidence that stimulation of megakaryocytopoiesis by low dose vincristine results from an effect on platelets.
abstract: Appropriate low dosages of vincristine stimulate megakaryocytopoiesis and produce thrombocytosis. In this study of the thrombocytotic action of vincristine, administration of a single dose of 0.1 mg/kg to rats produced an increase in megakaryocyte concentration, diameter and 24 h [3H]thymidine labelling index. Transfusion of one body equivalent of platelets from normal donors prevented stimulation of megakaryocytopoiesis by vincristine whereas platelets from vincristine-treated donors did not. These results suggest that vincristine stimulates megakaryocytopoiesis by altering the functional role of circulating platelets in the regulation of thrombopoiesis.
mesh_terms: D000818:Animals; D001792:Blood Platelets / Q000187:drug effects*; D008533:Megakaryocytes / Q000187:drug effects* / Q000378:metabolism; D017713:Platelet Transfusion; D051381:Rats; D013922:Thrombocytosis / Q000139:chemically induced; D014750:Vincristine / Q000494:pharmacology*
chemical_list: D014750:Vincristine