Effects of hemicholinium-3 or physostigmine on rat brain noradrenaline depletion induced by foot shocks.
Foot shocks applied to the rat on a grid floor caused brain noradrenaline depletion. Hemicholinium-3 injected intracerebroventricularly (i.c.v.) blocked the noradrenaline depletion and this blockade was reversed by choline (i.c.v.). Physostigmine (i.c.v.) had different effects according to the age of the rats: "young" and "intermediate" groups were depleted but not "adult" groups. Physostigmine plus shocks caused depletion only in "young" groups; the depletion not shown in "intermediat" groups, reappeared after pretreatment with alpha-methyl-p-tyrosine. It is concluded that there probably is a relationship between cholinergic and adrenergic neural systems when brain noradrenaline id depleted by shocks.
D000367:Age Factors; D000818:Animals; D001923:Brain Chemistry / Q000187:drug effects*; D002794:Choline / Q000494:pharmacology; D004347:Drug Interactions; D004597:Electroshock; D006426:Hemicholinium 3 / Q000008:administration & dosage / Q000494:pharmacology*; D007276:Injections, Intraventricular; D008297:Male; D008781:Methyltyrosines / Q000494:pharmacology; D009638:Norepinephrine / Q000032:analysis*; D010830:Physostigmine / Q000008:administration & dosage / Q000494:pharmacology*; D051381:Rats; D013997:Time Factors
D008781:Methyltyrosines; D006426:Hemicholinium 3; D010830:Physostigmine; D002794:Choline; D009638:Norepinephrine