Effects of hyperoxia on glutathione reductase activity, membrane proteins, and esterases of rabbit erythrocytes.
Rabbits were exposed to 100% oxygen at pressures of 256 to 1520 mm Hg for up to 5 d and the blood and erythrocytes of these animals were examined for changes that could be related to hyperoxia. Glutathione reductase activity of erythrocytes was reduced 5 to 29% by hyperoxia, whereas that of the plasma was not significantly altered. Significant changes in red and white cell counts, including differential leukocyte count, could not be detected. Electrophoretic analysis of the proteins and esterases derived from plasma and membranes and cytoplasmic fractions of erythrocytes did not reveal changes attributable to hyperoxia.
D000818:Animals; D001274:Atmospheric Pressure; D001772:Blood Cell Count; D001797:Blood Protein Electrophoresis; D001798:Blood Proteins / Q000378:metabolism*; D004910:Erythrocyte Membrane / Q000187:drug effects / Q000201:enzymology / Q000378:metabolism; D004912:Erythrocytes / Q000187:drug effects* / Q000201:enzymology / Q000378:metabolism; D004950:Esterases / Q000097:blood*; D005260:Female; D005980:Glutathione Reductase / Q000097:blood*; D008297:Male; D008565:Membrane Proteins / Q000097:blood*; D010100:Oxygen / Q000506:poisoning*; D011817:Rabbits
D001798:Blood Proteins; D008565:Membrane Proteins; D005980:Glutathione Reductase; D004950:Esterases; D010100:Oxygen