title: The effects of methaqualone on the temperature regulation of mice.
abstract: Methaqualone produces dose and time dependent changes in the rectal temperature of mice. More specifically, the drug produces poikilothermia. This effect appears to be produced by methaqualone itself rather than a liver metabolite since SKF525A, a compound known to block drug metabolizing enzymes in the liver, does not abolish the phenomenon. Tolerance to the temperature altering effects of methaqualone is also shown.
mesh_terms: D000818:Animals; D001833:Body Temperature Regulation / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D004347:Drug Interactions; D004361:Drug Tolerance; D008297:Male; D008702:Methaqualone / Q000008:administration & dosage / Q000494:pharmacology*; D051379:Mice; D008810:Mice, Inbred C57BL; D011335:Proadifen / Q000494:pharmacology; D013696:Temperature; D013997:Time Factors
chemical_list: D008702:Methaqualone; D011335:Proadifen