Primary tumor immunity in nude mice.
Tumor implants grew better in radiated or in newborn nu/nu mice than in adult nu/nu controls when, and only when, the tumors were demonstrably immunogenic in normal mice. This result suggests primary immunity. No evidence of immunological memory was found by immunization-challenge type experiments in the nude mice.
D000818:Animals; D000831:Animals, Newborn; D000951:Antigens, Neoplasm; D002471:Cell Transformation, Neoplastic / Q000528:radiation effects; D007114:Immunization; D007156:Immunologic Memory / Q000528:radiation effects; D008748:Methylcholanthrene; D051379:Mice; D008819:Mice, Nude / Q000276:immunology*; D009368:Neoplasm Transplantation; D009374:Neoplasms, Experimental / Q000139:chemically induced / Q000276:immunology*
D000951:Antigens, Neoplasm; D008748:Methylcholanthrene