title: The effect of insulin on vascular reactivity to norepinephrine.
abstract: The effect of insulin on the vasoconstrictor response to norepinephrine of the resistance bed of the isolated perfused rat tail has been studied. Insulin produced a significant attenuation of this response in concentrations of both 120 mU./ml. and 150 micronU./ml. It is suggested that this effect may be relevant to the hypotensive action of insulin observed in diabetics.
mesh_terms: D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D005260:Female; D066298:In Vitro Techniques; D007328:Insulin / Q000494:pharmacology*; D008297:Male; D009638:Norepinephrine / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D051381:Rats; D013623:Tail / Q000098:blood supply; D014655:Vascular Resistance / Q000187:drug effects; D014662:Vasoconstrictor Agents; D014666:Vasomotor System / Q000187:drug effects*
chemical_list: D007328:Insulin; D014662:Vasoconstrictor Agents; D009638:Norepinephrine