Sister chromatid exchanges in human lymphocytes exposed to 8-methoxypsoralen and long wave UV radiation prior to incorporation of bromodeoxyuridine.
Human lymphocytes exposed to the effects of long wave UV radiation in the presence of 8-methoxypsoralen prior to stimulation by PHA show dose related sister chromatid exchanges after 2 replication cycles in vitro. This has implications for interpreting the processes involved and for monitoring DNA damaging agents in vivo.
D001973:Bromodeoxyuridine / Q000494:pharmacology; D002842:Chromatids; D004305:Dose-Response Relationship, Drug; D006801:Humans; D066298:In Vitro Techniques; D008214:Lymphocytes / Q000187:drug effects / Q000528:radiation effects / Q000648:ultrastructure*; D008730:Methoxsalen / Q000494:pharmacology*; D013997:Time Factors; D014466:Ultraviolet Rays
D001973:Bromodeoxyuridine; D008730:Methoxsalen