Permeability of the liver cell membrane to quinolinate.
Quinolinate was taken up by both rat and guinea-pig liver cells. Equilibrium was reached after approx. 20 min with rat cells, but guinea-pig cells had not achieved a steady state after 60 min. There was no evidence to suggest that quinolinate is rapidly metabolized by either species. The concentrations of quinolinate attained in rat and guinea-pig cells after short periods of incubation with 0.5 mM-quinolinate did not inhibit gluconeogenesis. These results raise further doubts as to the mechanism of quinolinate action in liver.
D000818:Animals; D002462:Cell Membrane / Q000378:metabolism; D002463:Cell Membrane Permeability; D003921:Diabetes Mellitus, Experimental / Q000378:metabolism; D005508:Food Deprivation; D005943:Gluconeogenesis / Q000187:drug effects; D006168:Guinea Pigs; D008099:Liver / Q000378:metabolism*; D008297:Male; D011725:Pyridines / Q000378:metabolism*; D011805:Quinolinic Acids / Q000378:metabolism* / Q000494:pharmacology; D051381:Rats; D013045:Species Specificity; D013997:Time Factors
D011725:Pyridines; D011805:Quinolinic Acids