[Comparative clinical studies on clomiphen, cyclofenil and epimestrol (author's transl)].
Report on the treatment of 310 anovulatory woment in 1173 treatment cycles with Clomiphen, Cyclofenil and Epimestrol. 63% of the patients had a biphasic basal body temperature record after treatment in 718 cycles. Patients with secondary amenorrhea of the first or the second degree had a satisfactory ovulation rate in 71% of the cases only by treatment with Clomiphen. In women with anovulatory cycles an overall ovulation rate of 75% was observed with all three medications. In 73 patients 78 pregnancies occurred. Of these, 38 pregnancies followed Cyclofenil, 25 pregnancies followed Clomiphen and 15 pregnancies followed Epimestrol corresponding to a 15%, 17% and 13% rate in the treated patients. 22 of these pregnancies ended in incomplete abortion. The side effects of Clomiphen especially visual and cystic ovarian and vasomotor side effects are more pronounced than the side effects of Cyclofenil and Epimestrol. The statistical analysis of the clinical results showed that Clomiphen and Cyclofenil had a higher rate of ovulation in secondary amenorrhea of the first or second degree than Epimestrol.
D000568:Amenorrhea / Q000188:drug therapy; D000858:Anovulation / Q000188:drug therapy*; D001831:Body Temperature; D002996:Clomiphene / Q000009:adverse effects / Q000627:therapeutic use*; D003408:Cresols / Q000627:therapeutic use*; D003506:Cyclofenil / Q000009:adverse effects / Q000627:therapeutic use*; D004836:Epimestrol / Q000009:adverse effects / Q000627:therapeutic use*; D004963:Estrenes / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D011247:Pregnancy; D014786:Vision Disorders / Q000139:chemically induced
D003408:Cresols; D004963:Estrenes; D002996:Clomiphene; D004836:Epimestrol; D003506:Cyclofenil
Vergleichende klinische Untersuchungen von Clomiphen, Cyclofenil und Epimestrol.