title: Brain and blood lead in acute intoxication.
abstract: Administering lead acetate in drinking water to adult male rats resulted in an elevated lead content in blood and brain during 11 subsequent days. The brain and blood lead contents were proportional to each other although the interdependency changed according to the cumulative dose and equilibration period. The present data indicate that the permeability of the blood-brain barrier towards inorganic lead may be dose-dependent and saturable with high doses of the metal.
mesh_terms: D000818:Animals; D001812:Blood-Brain Barrier; D001921:Brain / Q000378:metabolism*; D004305:Dose-Response Relationship, Drug; D007854:Lead / Q000097:blood / Q000378:metabolism*; D007855:Lead Poisoning / Q000378:metabolism*; D008297:Male; D051381:Rats; D013997:Time Factors
chemical_list: D007854:Lead