[Non-steroid anti-inflammatory agents. Stereoisomers of 2-(-4-biphenylyl)-3-oxybutyric acid].
The synthesis, diastereoisomeric separation, attribution to erythro and threo series, and resolution of the enantiomers of 2-(4-biphenylyl)-3-oxybutyric acid are described. The four isomers were tested for anti-inflammatory activity: the preliminary results are interesting, particular those for the (--) erythro enantiomer.
D000893:Anti-Inflammatory Agents / Q000138:chemical synthesis*; D002087:Butyrates / Q000138:chemical synthesis*; D055598:Chemical Phenomena; D002621:Chemistry; D004353:Drug Evaluation, Preclinical; D009682:Magnetic Resonance Spectroscopy; D013237:Stereoisomerism
D000893:Anti-Inflammatory Agents; D002087:Butyrates
Antiinfiammatori non steroidei. Nota I - Stereoisomeri dell'acido 2-(4-bifenilil)-3-ossibutirrico