Cytotoxicity of Ro-07-0582; enhancement by hyperthermia and protection by cysteamine.
The selective cytotoxicity which Ro-07-0582 exhibits towards hypoxic cells is strongly temperature-dependent. This cytotoxicity is reduced by the radical scavenger cysteamine, suggesting that nitro radicals or nitroso intermediates are involved in cell killing by the drug. Chromosome aberrations are not induced by Ro-07-0582 even when the surviving fraction is reduced to 0-01.
D002470:Cell Survival / Q000187:drug effects* / Q000528:radiation effects; D002478:Cells, Cultured; D002869:Chromosome Aberrations; D003543:Cysteamine / Q000494:pharmacology*; D005720:Gamma Rays; D006358:Hot Temperature; D000860:Hypoxia; D009593:Nitroimidazoles / Q000494:pharmacology*; D013997:Time Factors
D009593:Nitroimidazoles; D003543:Cysteamine