Effects of tranylcypromine and pargyline on brain tryptamine.
Tranylcypromine produces behavioral excitation while pargyline produces depression. Tranylcypromine increased brain tryptophan which led to an accumulation of tryptamine. The levels of tryptamine after tranylcypromine were found to be 3 times those found after pargyline.
D000818:Animals; D001921:Brain / Q000187:drug effects / Q000378:metabolism*; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D010293:Pargyline / Q000494:pharmacology*; D014191:Tranylcypromine / Q000494:pharmacology*; D014363:Tryptamines / Q000378:metabolism*; D014364:Tryptophan / Q000494:pharmacology; D014439:Tyramine / Q000378:metabolism
D014363:Tryptamines; D014191:Tranylcypromine; D014364:Tryptophan; D010293:Pargyline; D014439:Tyramine