[Pathogenesis of chronic alcohosim].
The paper is concerned with a study of the enzyme activity which reflects the functional state of the liver in 123 patients with chronic alcoholism (without clinical signs of disturbed liver function). The blood serum was studied for sorbitdehydrogenase, frutose-I-phosphataldolase, glutamino-asparagine and glutamine-alanine transamine. It was established that there is an increase in the activity of specific and nonspecific liver enzymes. This increase was in a direct correlation with the clinical expression and severity of the disease (withdrawal syndrome, delirious condition). It is being concluded that the indices of the level of enzyme activity may be used for the evaluation of the state of the patients and its change under the effect of treatment.
D000328:Adult; D000410:Alanine Transaminase / Q000378:metabolism; D001219:Aspartate Aminotransferases / Q000378:metabolism; D005634:Fructose-Bisphosphate Aldolase / Q000378:metabolism; D006801:Humans; D007064:L-Iditol 2-Dehydrogenase / Q000378:metabolism; D008099:Liver / Q000201:enzymology*; D008297:Male; D008875:Middle Aged; D011604:Psychoses, Alcoholic / Q000201:enzymology*; D013375:Substance Withdrawal Syndrome / Q000201:enzymology*
D007064:L-Iditol 2-Dehydrogenase; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase; D005634:Fructose-Bisphosphate Aldolase
K patogenezu khronicheskogo alkogolizma