[Effect of hydrocortisone on the concentration of serotonin and monoamine oxidase activity in the vascular tract of the eye].
Effect of hydrocortisone on content of serotonin was studied in eye vascular tract or blood and the monoamine oxidase (MAO) activity was estimated in eye vascular tract of young and adult rabbits at various periods after administration of hydrocortisone under conjunctiva. After administration of hydrocortisone content of serotonin was increased in eye vascular tract and decreased in blood. Maximal serotonin reaction was observed in vascular tract of adult rabbits within 24 hrs after the hydrocortisone treatment and in one-month-old rabbits--within 4-6 hrs. In blood of adult animals the most distinct decrease in serotonin content was found within 4-6 hrs after the single administration of the preparation; in one-month-old rabbits the effect was observed after the repeated treatment within 7 days. Effect of hydrocortisone on the MAO activity in eye vascular tract varied depending on the age. In one-month-old rabbits the MAO activity was increased distinctly within 24 hrs after single administration of the preparation and in adult animals the enzyme activity was decreased within 4-6 hrs and did not alter at the other periods after the hydrocortisone administration.
D000367:Age Factors; D000818:Animals; D002682:Chinchilla; D006854:Hydrocortisone / Q000494:pharmacology*; D008995:Monoamine Oxidase / Q000378:metabolism*; D011817:Rabbits; D012701:Serotonin / Q000378:metabolism*; D013997:Time Factors; D014602:Uvea / Q000187:drug effects* / Q000201:enzymology / Q000378:metabolism
D012701:Serotonin; D008995:Monoamine Oxidase; D006854:Hydrocortisone
Vliianie gidrokortizona na soderzhanie serotonina i aktivnost' monoaminoksidazy v sosudistom trakte glaza.