In vitro effects of fatty acids on serum-ionized calcium.
Ionized calcium was determined in vitro in human serum in relation to increased concentrations (0.32 to 10 mM) of free fatty acids. Serum iCa levels varied inversely and linearly with increasing FFA concentrations. It is suggested that the formation of Ca-FFA complexes at clinically attainable levels of FFA decreases iCa and that elevated serum FFA levels may be a factor in the development of hypocalcemia.
D000328:Adult; D002118:Calcium / Q000097:blood*; D004305:Dose-Response Relationship, Drug; D005230:Fatty Acids, Nonesterified / Q000494:pharmacology*; D005312:Fetal Blood; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D009829:Oleic Acids / Q000097:blood / Q000494:pharmacology; D010169:Palmitic Acids / Q000097:blood / Q000494:pharmacology
D005230:Fatty Acids, Nonesterified; D009829:Oleic Acids; D010169:Palmitic Acids; D002118:Calcium