Gas-liquid chromatographic micromethod for the determination of theophylline.
A micromethod for the determination of theophylline using gas-liquid chromatography is described. The volatile ethylated derivative is prepared by the flash-heater derivatization technique. Substances that interfere in the classical determination of theophylline such as caffeine and phenobarbital did not interfere in this procedure. The coefficient of variation was 2.1 percent for 5 microgram/ml and 5.4 percent for 40 microgram/ml. This determination is useful for assessing patient compliance and adjusting dosage schedules.
D002849:Chromatography, Gas / Q000379:methods*; D002853:Chromatography, Liquid / Q000379:methods*; D006801:Humans; D008832:Microchemistry / Q000379:methods; D013806:Theophylline / Q000097:blood*
D013806:Theophylline