Effect of hypolipidemia on testosterone-stimulated prostatic growth in castrated rats.
Hypolipidemia caused by Simfibrate feeding for 3 weeks reduced responses of weight and nucleic acid contents to testosterone administration in the ventral and dorsolateral prostates of castrated rats. However, the effect of testosterone on the contents of citrate, fructose, zinc and the activity of testosterone 5alpha-reductase in the glands of castrated animals was not modified by Simfibrate feeding.
D013741:3-Oxo-5-alpha-Steroid 4-Dehydrogenase / Q000032:analysis; D000821:Animal Feed; D000818:Animals; D001835:Body Weight / Q000187:drug effects; D002369:Castration; D002784:Cholesterol / Q000097:blood*; D004247:DNA / Q000032:analysis; D005632:Fructose / Q000032:analysis; D008297:Male; D009929:Organ Size / Q000187:drug effects; D011467:Prostate / Q000032:analysis / Q000033:anatomy & histology* / Q000201:enzymology; D012313:RNA / Q000032:analysis; D051381:Rats; D013739:Testosterone / Q000494:pharmacology*; D014280:Triglycerides / Q000097:blood*
D014280:Triglycerides; D005632:Fructose; D013739:Testosterone; D012313:RNA; D004247:DNA; D002784:Cholesterol; D013741:3-Oxo-5-alpha-Steroid 4-Dehydrogenase