title: The effect of prostaglandin inhibition on the natriuresis of drug-induced renal vasodilatation.
abstract: It has been suggested that increased prostaglandin release may mediate the natriuresis seen during the administration of renal vasodilators. To further investigate this possibility, either acetylcholine (40 microgram/min) or bradykinin (5 microgram/min) was infused into the left renal artery of anesthetized dogs previously given an inhibitor of prostaglandin synthesis. During the infusion of either vasodilator drug in the prostaglandin-inhibited dogs, urinary sodium excretion increased to a similar degree as in a group of normal dogs with intact prostaglandin synthesis. These studies therefore do not confirm that prostaglandins play a significant role in the natriuresis of drug-induced vasodilatation.
mesh_terms: D000109:Acetylcholine / Q000494:pharmacology*; D000818:Animals; D001920:Bradykinin / Q000494:pharmacology*; D004285:Dogs; D009318:Natriuresis / Q000187:drug effects*; D011448:Prostaglandin Antagonists / Q000494:pharmacology*; D011453:Prostaglandins / Q000494:pharmacology; D014666:Vasomotor System / Q000187:drug effects*
chemical_list: D011448:Prostaglandin Antagonists; D011453:Prostaglandins; D000109:Acetylcholine; D001920:Bradykinin