title: Plasma renin activity in pregnant women with oedema treated with hydrochlorothiazide.
abstract: Fourteen pregnant women with oedema and inappropriate weight gain were treated with hydrochlorothiazide, 50 mg daily. Plasma renin activity (PRA) increased form 2.89 +/- 0.44 (mean +/- SEM) to 10.46 +/- 1.61 ng/ml/h after one week and remained high (10.07 +/- 1.36 ng/ml/h) after three weeks of drug therapy. Eight women were considered to be "responsers" because of a marked increase of PRA) (greater than 9.5 ng/ml/h) and six subjects ranked as "weak responders", with PRA increases of less than 6.0 ng/ml/h. These subgroups had different patterns of sodium excretion, weight loss and systolic blood pressure. The different reactivity of the renin-angiotensin system suggests that there may be at least two, basically different, types of pathophysiology in pregnancy associated edema.
mesh_terms: D000328:Adult; D004487:Edema / Q000097:blood / Q000188:drug therapy*; D005260:Female; D006801:Humans; D006852:Hydrochlorothiazide / Q000627:therapeutic use*; D009318:Natriuresis; D011247:Pregnancy; D011248:Pregnancy Complications / Q000188:drug therapy*; D012083:Renin / Q000097:blood*; D012964:Sodium / Q000652:urine
chemical_list: D006852:Hydrochlorothiazide; D012964:Sodium; D012083:Renin