Syngeneic tumor rejection induced by immunization with normal allogeneic tissues.
Immunization with normal allogeneic kidney and liver tissues extends survival of DBA/2Cr mice challenged with a lethal dose of syngeneic L517BY lymphoma cells. Immunization with a combination of tissues from five strains provides far more protection than immunization with tissue from any single strain. It is suggested that the basis of this protective effect is a cross-reactivity or identity between tumor-associated transplantation antigens (TATA) on the L5178Y tumor and non-H-2 alloantigens normally expressed by some allogeneic tissues.
D000818:Animals; D005260:Female; D007114:Immunization; D007668:Kidney / Q000276:immunology; D008099:Liver / Q000276:immunology; D008223:Lymphoma / Q000276:immunology* / Q000401:mortality; D051379:Mice; D008805:Mice, Inbred A; D008806:Mice, Inbred AKR; D008807:Mice, Inbred BALB C; D008810:Mice, Inbred C57BL; D008811:Mice, Inbred DBA; D009374:Neoplasms, Experimental; D014181:Transplantation Immunology