title: Gastric acid secretion in patients with symptomatic hiatus hernia and effect of a modified Belsey MK IV repair on gastric acid secretion.
abstract: Fasting, basal, and pentagastrin-stimulated (6 microgram/kg body weight) gastric acid secretion was assessed in 53 patients with radiologically verified sliding hiatus hernia without stricture formation. There was no difference in the acid secretory variables between patients with heartburn and those with heartburn and pain. A study of the acid secretory variables in 34 patients before and 3 months after a modified Belsey MK IV repair for symptomatic hiatus hernia showed that after the repair the pH of basal secretion had risen, and that the volume of basal secretion as well as basal and peak acid output had been reduced. These changes must probably be ascribed to an unintentional vagotomy during the operation. It is concluded that in the evaluation of a surgically established barrier against gastro-oesophageal reflux in terms of oesophageal pH, changes in gastric acid secretion should be taken into consideration.
mesh_terms: D000328:Adult; D000368:Aged; D003680:Deglutition Disorders; D005260:Female; D005750:Gastric Juice / Q000378:metabolism*; D005764:Gastroesophageal Reflux; D006356:Heartburn; D006548:Hernia, Diaphragmatic / Q000503:physiopathology*; D006551:Hernia, Hiatal / Q000503:physiopathology* / Q000601:surgery; D006801:Humans; D008297:Male; D008875:Middle Aged; D010146:Pain; D010418:Pentagastrin; D012636:Secretory Rate
chemical_list: D010418:Pentagastrin