title: Effect of buprenorphine on the ventilatory response to carbon dioxide.
abstract: Buprenorphine is a potent synthetic opioid-partial antagonist analgesic drug currently under clinical trial. When administered intravenously to human volunteers buprenorphine produced a significant depression of the ventilatory response to carbon dioxide stimulus for a period in excess of six hours.
mesh_terms: D000700:Analgesics / Q000008:administration & dosage / Q000494:pharmacology*; D002245:Carbon Dioxide / Q000032:analysis; D004781:Environmental Exposure; D006801:Humans; D007275:Injections, Intravenous; D009019:Morphinans / Q000008:administration & dosage / Q000494:pharmacology*; D012119:Respiration / Q000187:drug effects*; D013147:Spirometry
chemical_list: D000700:Analgesics; D009019:Morphinans; D002245:Carbon Dioxide