Synthesis and antiinflammatory activity of some 2-aryl-6-benzoxazoleacetic acid derivatives.
Various approaches to the synthesis of 2-aryl-6-substituted benzoxazoles are described. The products, which included the 6-methyl derivative 4a, ethylamines 10 and 19, ethanols 12 and 14, the acetic and alpha-methylacetic acids 9 and 16a--f, and the acetic ester 11, were screened for antiinflammatory activity on the carrageenan-induced rat paw edema test. Some of the compounds possessed activity superior to that of phenylbutazone and of the same order as that of benoxaprofen.
D000315:Adrenalectomy; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000138:chemical synthesis* / Q000627:therapeutic use / Q000633:toxicity; D001583:Benzoxazoles / Q000138:chemical synthesis* / Q000627:therapeutic use / Q000633:toxicity; D004487:Edema / Q000188:drug therapy; D007249:Inflammation / Q000188:drug therapy; D007928:Lethal Dose 50; D051381:Rats
D000893:Anti-Inflammatory Agents; D001583:Benzoxazoles