Evaluation of blood glucose, insulin, growth hormone and cortisol response in heroin addicts.
Oral glucose tolerance tests were performed on 16 addicts and 16 control subjects. A flat delayed glucose response was demonstrated, with hyperinsulinaemia, elevated plasma growth hormone and normal plasma cortisol in heroin addicts compared with control subjects. These studies suggest a relative insulin resistance in addicts which might be mediated by the elevated growth hormone or some other pharmacologic effect of the chronic opiate abuse.
D000293:Adolescent; D000328:Adult; D001786:Blood Glucose / Q000378:metabolism*; D005260:Female; D005951:Glucose Tolerance Test; D013006:Growth Hormone / Q000097:blood; D006556:Heroin Dependence / Q000097:blood* / Q000503:physiopathology; D006801:Humans; D006854:Hydrocortisone / Q000097:blood*; D007328:Insulin / Q000097:blood*; D007333:Insulin Resistance; D008297:Male
D001786:Blood Glucose; D007328:Insulin; D013006:Growth Hormone; D006854:Hydrocortisone