Increased expression in erythrocytic Ii antigens in sickle cell disease and sickle cell trait.
The reactivity of human erythrocytes with anti-I and anti-i sera was estimated in 36 normal adults, 18 individuals with sickle cell anemia and 27 individuals with sickle cell trait, by quantitative hemagglutination with a sensitive autoanalyzer system. SS erythrocytes showed significantly increased I and i reactivity when compared to normal erythrocytes. AS erythrocytes also demonstrated some increase in Ii reactivity. No correlation was found between erythrocytic HbF content and i reactivity.
D000328:Adult; D000755:Anemia, Sickle Cell / Q000276:immunology*; D004912:Erythrocytes / Q000276:immunology; D005260:Female; D005312:Fetal Blood / Q000276:immunology; D005319:Fetal Hemoglobin / Q000032:analysis; D006801:Humans; D007048:I Blood-Group System; D007231:Infant, Newborn; D007519:Isoantigens / Q000032:analysis*; D008297:Male; D012805:Sickle Cell Trait / Q000276:immunology*
D007048:I Blood-Group System; D007519:Isoantigens; D005319:Fetal Hemoglobin