Regression of bovine ocular carcinoma by treatment with a mycobacterial vaccine.
Hereford cows with naturally occurring ocular squamous cell carcinoma were treated by injection of BCG cell-wall vaccine into the tumor. Regression or arrest of disease was observed in 71% of treated animals. The disease progressed in all untreated animals and animals treated with improperly compounded vaccine. At autopsy, most animals with progressive disease had lymph node metastases.
D000818:Animals; D001500:BCG Vaccine / Q000627:therapeutic use*; D002294:Carcinoma, Squamous Cell / Q000473:pathology / Q000628:therapy / Q000662:veterinary*; D002417:Cattle; D002418:Cattle Diseases / Q000628:therapy*; D005134:Eye Neoplasms / Q000473:pathology / Q000628:therapy / Q000662:veterinary*; D005260:Female; D007167:Immunotherapy; D008207:Lymphatic Metastasis; D009362:Neoplasm Metastasis; D009374:Neoplasms, Experimental / Q000473:pathology; D011247:Pregnancy; D012075:Remission, Spontaneous
D001500:BCG Vaccine