[Histogenesis of stomach cancer and the role of intestinal metaplasia in the process].
The study of 854 gastrobioptic specimens and 102 stomachs resected in connection with cancer justified the assumption that intestinal metaplasia as such was not of a precancer character but indicated only the presence of a pathological process in the stomach. Malignization started in places of atypical hyperplasia of the epithelium, mostly at the level of the cervical part of the glands and gastric fossae. The investigations conducted showed that under conditions of pathology proliferation of cambial elements could occur by two ways. In some cases the typical epithelium is formed (foci of morphological precancer of the stomach) representing a source of cancerous transformation; in other cases, proliferation of the cambial elements terminates with inderect metaplasia with origination of an entirely differentiated epithelium of the intestinal type.
D000328:Adult; D000368:Aged; D002278:Carcinoma in Situ / Q000473:pathology; D002471:Cell Transformation, Neoplastic; D002908:Chronic Disease; D004848:Epithelium; D005260:Female; D005753:Gastric Mucosa / Q000473:pathology*; D005756:Gastritis / Q000473:pathology*; D006801:Humans; D006965:Hyperplasia; D008297:Male; D008679:Metaplasia; D008875:Middle Aged; D013274:Stomach Neoplasms / Q000473:pathology*
K voprosu o gistogeneze raka zheludka i roli kishechnoĭ metaplazii v étom protsess