The effect of heparin on the interaction of factor VIII and human platelets in vitro.
Heparin was found to inhibit the interaction between human factor VIII and platelets. This was noted in two different systems, namely, platelet aggregation induced by neuraminidase-treated human cryoprecipitate and platelet aggregation induced by ristocetin-human factor VIII complex. Heparin appeared to have an inhibitory effect on the above systems similar to that reported on bovine factor VIII-induced platelet aggregation.
D001792:Blood Platelets / Q000378:metabolism*; D011232:Chemical Precipitation; D003450:Cryoglobulins; D005169:Factor VIII / Q000378:metabolism*; D006493:Heparin / Q000494:pharmacology*; D006801:Humans; D066298:In Vitro Techniques; D009439:Neuraminidase / Q000494:pharmacology; D010974:Platelet Aggregation / Q000187:drug effects; D012310:Ristocetin / Q000494:pharmacology
D003450:Cryoglobulins; D012310:Ristocetin; D005169:Factor VIII; D006493:Heparin; D009439:Neuraminidase