title: [Nitrazepam metabolism in the intestines of white rats].
abstract: Nitrasepam is transformed to amino and acetamide derivatives in the rat intestine. Reduction of nitrasepam and its following acetylation in the duodenum and small intestine are catalyzed by the mucosal enzymes. In the cecum and the large intestine these processes are mediated through the action of the microbes and tissue enzymes, whereas in the rectum--through the microbes only.
mesh_terms: D000081:Acetamides / Q000378:metabolism; D000588:Amines / Q000378:metabolism; D000818:Animals; D001419:Bacteria / Q000378:metabolism; D001711:Biotransformation; D002432:Cecum / Q000378:metabolism; D004386:Duodenum / Q000378:metabolism; D007413:Intestinal Mucosa / Q000378:metabolism*; D007420:Intestine, Large / Q000378:metabolism; D007421:Intestine, Small / Q000378:metabolism; D007422:Intestines / Q000201:enzymology / Q000382:microbiology; D008297:Male; D009567:Nitrazepam / Q000378:metabolism*; D010088:Oxidoreductases / Q000378:metabolism; D051381:Rats; D012007:Rectum / Q000378:metabolism
chemical_list: D000081:Acetamides; D000588:Amines; D009567:Nitrazepam; D010088:Oxidoreductases
vernacular_title: Metabolizm nitrazepama v kishechnike belykh krys.