Interferon induction in human cell cultures by small molecular inducers (tilorone and acridines).
Attempts were made to stimulate interferon production in human cell cultures by two related acridin drugs, mepacrine and Acranil. Tilorone was included for comparison. In human embryo lung fibroblasts and in normal human leukocytes only tilorone stimulated some interferon production. All three drugs stimulated modest interferon production in two lymphoblastoid cell lines. All three drugs enhanced the Sendai virus-induced interferon production in lymphoblastoid cells.
D000166:Acridines / Q000494:pharmacology*; D002478:Cells, Cultured; D005347:Fibroblasts / Q000378:metabolism; D005449:Fluorenes / Q000494:pharmacology*; D006801:Humans; D007369:Interferon Inducers; D007372:Interferons / Q000096:biosynthesis*; D007962:Leukocytes / Q000378:metabolism; D008970:Molecular Weight; D011796:Quinacrine / Q000494:pharmacology; D013994:Tilorone / Q000494:pharmacology*
D000166:Acridines; D005449:Fluorenes; D007369:Interferon Inducers; D007372:Interferons; D011796:Quinacrine; D013994:Tilorone