title: The effect of anticonvulsant drugs on thymidine and deoxyribosenucleic acid synthesis by human marrow cells.
abstract: An abnormal deoxyuridine suppression test was found in treated epileptic patients that did not correlate with other evidence of abnormal folate metabolism. Diphenylhydantoin at a level of 100 microgram/ml interfered with the incorporation of [3H]thymidine into DNA. It is suggested that anticonvulsants may exert their effect at a stage of DNA synthesis beyond that at which folate coenzymes operate. Folate deficiency may then arise as a result of death of cells in vivo causing an increased folate requirement.
mesh_terms: D000927:Anticonvulsants / Q000494:pharmacology*; D001853:Bone Marrow / Q000187:drug effects* / Q000378:metabolism; D001854:Bone Marrow Cells; D004247:DNA / Q000096:biosynthesis*; D003857:Deoxyuridine / Q000378:metabolism; D005492:Folic Acid / Q000032:analysis; D006801:Humans; D010672:Phenytoin / Q000494:pharmacology; D013936:Thymidine / Q000096:biosynthesis*; D014805:Vitamin B 12 / Q000032:analysis
chemical_list: D000927:Anticonvulsants; D010672:Phenytoin; D004247:DNA; D005492:Folic Acid; D014805:Vitamin B 12; D013936:Thymidine; D003857:Deoxyuridine