Various 5-substituted and 2,5-disubstituted 1,3-dioxanes, a new class of analgesic agents.
A series of 5-substituted and 2,5-disubstituted 1,3-dioxanes was prepared and evaluated for analgesic activity in mice and rats. Some of the compounds possessed significant analgesic effects; their structure-activity relationships and chemistry are discussed. These compounds represent a unique series of analgesic agents.
D000700:Analgesics / Q000138:chemical synthesis*; D000818:Animals; D004146:Dioxanes / Q000138:chemical synthesis* / Q000494:pharmacology; D004147:Dioxins / Q000138:chemical synthesis*; D051381:Rats; D011930:Reaction Time / Q000187:drug effects; D013329:Structure-Activity Relationship
D000700:Analgesics; D004146:Dioxanes; D004147:Dioxins