title: Iron removal from transferrin. An experimental study.
abstract: We have studied the facilitation of iron transfer from transferrin to desferrioxamine by various anions. Most of the anions which can substitute for HCO-3 in the ternary complex of transferrin - Fe - HCO3 do not facilitate iron transfer; anions which do facilitate iron transfer do not necessarily form stable ternary complexes. Combinations of anions effective in transfer have a less-than-additive effect, suggesting a common reaction pathway. We suggest that the transfer of iron from transferrin to desferrioxamine involves a substitution step and a subsequent chelation step, and that the efficiency of the overall reaction is a function of both these attributes of the anion.
mesh_terms: D003676:Deferoxamine; D006801:Humans; D007501:Iron / Q000378:metabolism; D007700:Kinetics; D014168:Transferrin / Q000378:metabolism
chemical_list: D014168:Transferrin; D007501:Iron; D003676:Deferoxamine