title: Inhibition by somatostatin of gastrin release and gastric acid responses to meals and to pentagastrin in man.
abstract: The inhibitory actions of intravenous somatostatin on the gastric secretory responses to pentagastrin (1.5 microng/kg-h i.v.) and to a meal (10% peptone, pH 5.5) were studied in six healthy subjects. Meal-induced gastric acid output was estimated by means of a modified Fordtran and Walsh method of intragastric titration. Somatostatin (5 microng/kg-h; cyclic form) significantly inhibited the total 1-hour acid response to pentagastrin by about 70% (inhibition of pepsin secretion: about 70%) and that to a test meal by about 75%. During the last 30 min of somatostatin infusion the pentagastrin-stimulated secretion of acid was significantly reduced by about 90% (inhibition of pepsin output: about 85%) while the corresponding figure in the test with meal-induced secretion was about 95%. Serum gastric--elevated in response to the test meal--was found to be merely lowered by about 30% during somatostatin infusion. Consequently, it is tempting to assume that inhibition of human gastric acid secretion by exogenous somatostatin largely results from a direct antisecretory effect upon parietal cells and, only to a minor extent, from an indirect action via reduction of gastrin release.
mesh_terms: D000328:Adult; D005502:Food; D005750:Gastric Juice / Q000378:metabolism*; D005755:Gastrins / Q000097:blood / Q000378:metabolism*; D006801:Humans; D007275:Injections, Intravenous; D008297:Male; D010418:Pentagastrin / Q000494:pharmacology*; D012636:Secretory Rate / Q000187:drug effects; D013004:Somatostatin / Q000008:administration & dosage / Q000494:pharmacology*
chemical_list: D005755:Gastrins; D013004:Somatostatin; D010418:Pentagastrin