Regional cerebral blood flow in a case of bromide psychosis.
A case of bromide psychosis is described. A course of repeated measurements of the regional cerebral blood flow (rCBF) was followed, using the 133Xe inhalation method. At the first examination, when the serum bromide level was 45 mmol/1, the cerebral blood flow was reduced to about one-third of the normal. The regional flow pattern was also abnormal with low flows in frontal and parieto-occipital regions. Hemodialysis was performed with an overall improvement of the condition and a successive normalization of rCBF. The pronounced decrease of the cerebral blood flow, together with the positive effects of hemodialysis, seems to indicate that bromide psychosis is of a toxic origin and not an abstinence phenomenon.
D001965:Bromides / Q000009:adverse effects*; D002560:Cerebrovascular Circulation; D005260:Female; D006801:Humans; D008875:Middle Aged; D011605:Psychoses, Substance-Induced / Q000209:etiology / Q000503:physiopathology* / Q000628:therapy; D006435:Renal Dialysis; D014978:Xenon
D001965:Bromides; D014978:Xenon