Catatonic reactions to high-potency neuroleptic drugs.
Eight patients developed a syndrome marked by features of catatonia (including posturing, waxy flexibility, withdrawal and regression) and parkinsonism (including bradykinesia and rigidity) while receiving high-potency neuroleptic drugs. The syndrome had a gradual onset, responded slowly to withdrawal of the neuroleptic or use of an anticholinergic agent, but seemed to respond more rapidly to amantadine. The syndrome may easily be confused with a worsening of schizophrenic symptoms.
D000293:Adolescent; D000328:Adult; D000547:Amantadine / Q000008:administration & dosage; D002389:Catatonia / Q000139:chemically induced* / Q000188:drug therapy; D004305:Dose-Response Relationship, Drug; D005260:Female; D005476:Fluphenazine / Q000008:administration & dosage / Q000009:adverse effects*; D006220:Haloperidol / Q000008:administration & dosage / Q000009:adverse effects*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009771:Obsessive-Compulsive Disorder / Q000188:drug therapy; D010302:Parkinson Disease, Secondary / Q000139:chemically induced / Q000188:drug therapy; D012559:Schizophrenia / Q000188:drug therapy
D000547:Amantadine; D006220:Haloperidol; D005476:Fluphenazine