Depression of hepatic drug-metabolizing enzyme activity by B. pertussis vaccination.
In vitro measurements are described on N-demethylation of aminopyrine and ethylmorphine, the hydroxylation of aniline as well as the level and activity of the electron transport system in hepatic microsomal fractions from pertussis vaccinated mice. Results indicate that pertussis vaccination of mice markedly decreases the level and activity of the hepatic drug-metabolizing system.
D000632:Aminopyrine / Q000378:metabolism; D000814:Aniline Compounds / Q000378:metabolism; D000818:Animals; D004579:Electron Transport; D005260:Female; D066298:In Vitro Techniques; D008658:Inactivation, Metabolic; D008099:Liver / Q000201:enzymology*; D051379:Mice; D008862:Microsomes, Liver / Q000201:enzymology; D009022:Morphine Derivatives / Q000378:metabolism; D010567:Pertussis Vaccine / Q000494:pharmacology*
D000814:Aniline Compounds; D009022:Morphine Derivatives; D010567:Pertussis Vaccine; D000632:Aminopyrine