Renal blood flow autoregulation and renal venous prostaglandins in the pump-perfused canine kidney (in situ).
1. Renal autoregulation of blood flow was re-examined in the pump-perfused canine kidney and concentrations of prostaglandins E and F in the renal venous plasma were measured by radioimmunoassay. 2. At low perfusion pressures, below the range of autoregulation, prostaglandin E and F concentrations rose and calculated prostaglandin E secretion rate fell. 3. Meclofenamate (10 mg/kg i.v.) reduced renal blood flow and prostaglandin E and F secretion rates, but did not abolish autoregulation. 4. Renal prostaglandins do not appear to mediate autoregulation in the kidney but may affect the level at which flow is controlled.
D000818:Animals; D000906:Antibodies / Q000032:analysis; D001794:Blood Pressure / Q000187:drug effects; D004285:Dogs; D005260:Female; D007668:Kidney / Q000098:blood supply*; D008297:Male; D008469:Meclofenamic Acid / Q000494:pharmacology; D010477:Perfusion; D011453:Prostaglandins / Q000097:blood* / Q000276:immunology; D011458:Prostaglandins E / Q000097:blood / Q000502:physiology; D011460:Prostaglandins F / Q000097:blood / Q000502:physiology; D011863:Radioimmunoassay; D012039:Regional Blood Flow / Q000187:drug effects; D012082:Renal Veins
D000906:Antibodies; D011453:Prostaglandins; D011458:Prostaglandins E; D011460:Prostaglandins F; D008469:Meclofenamic Acid