title: The lumi-aggregometer: a new instrument for simultaneous measurement of secretion and aggregation by platelets.
abstract: We have developed a new instrument that simultaneously monitors aggregation and secretion of ATP from the same sample of platelets. Aggregation is determined by the usual turbidimetric method; secretion of ATP is followed by measuring luminescence from the firefly luciferase system at right angles to the aggregometer light path. Data are recorded on a two-pen strip chart recorder and reveal the temporal relations between the two platelet responses.
mesh_terms: D000255:Adenosine Triphosphate / Q000097:blood / Q000378:metabolism; D001792:Blood Platelets / Q000378:metabolism*; D003585:Cell Biology / Q000295:instrumentation*; D066298:In Vitro Techniques; D008027:Light; D008163:Luminescent Measurements; D010974:Platelet Aggregation
chemical_list: D000255:Adenosine Triphosphate