[Result of an antifibrinolytic treatment using tranexamic acid for the reduction of blood-loss during and after tonsillectomy].
Blood loss during and after tonsillectomy was assessed in 80 patients, 40 of whom were treated with tranexamic acid. A statistically significant reduction of blood loss (28%) was observed in this group during operation. Later bleedings occurred only in 27.5% (control: 67.5%) and stopped after 2 h (mean of control: 5.6h). Bleedings in the tranexamic acid group were mild and scarcely required other hemostyptic treatment, while in the control group some patients had to be treated with etamsylate or fibrogen for a longer period to stop bleeding. Tranexamic acid appears to be an effective and well-tolerated agent for reduction of blood loss caused by local hyperfibrinolysis.
D000293:Adolescent; D000328:Adult; D003509:Cyclohexanecarboxylic Acids / Q000627:therapeutic use*; D004341:Drug Evaluation; D005260:Female; D006470:Hemorrhage / Q000188:drug therapy*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009325:Nausea / Q000139:chemically induced; D011183:Postoperative Complications / Q000188:drug therapy*; D013997:Time Factors; D014068:Tonsillectomy; D014148:Tranexamic Acid / Q000009:adverse effects / Q000627:therapeutic use*; D014717:Vertigo / Q000139:chemically induced
D003509:Cyclohexanecarboxylic Acids; D014148:Tranexamic Acid
Der Erfolg einer antifibrinolytischen Behandlung mit Tranexamsäure zur Reduktion des Blutverlustes während und nach Tonsillektomien.