Heme catabolism in human kidneys. Effect of various nephritides.
The role of the kidneys in heme metabolism was examined by determining heme oxygenase and biliverdin reductase activities in needle biopsy specimens from the kidneys of 11 female and 14 male patients with different renal diseases. The results show that both enzymes are present in human renal tissue. Our results indicate that heme oxygenase and biliverdin reductase increase slightly with age, but that there is no sex difference. A rising serum creatinine concentration is not reflected in the activity of heme degrading enzymes. Neither do the different types of nephritides, without detectable hemolysis, show significant differences in the renal activities of heme oxygenase and biliverdin reductase. This study thus outlines the basal physiological role of the human kidneys in heme degradation.
D000293:Adolescent; D000328:Adult; D000367:Age Factors; D001663:Bilirubin / Q000378:metabolism; D001664:Biliverdine; D005260:Female; D006418:Heme / Q000378:metabolism*; D006454:Hemoglobins / Q000378:metabolism; D006801:Humans; D007668:Kidney / Q000378:metabolism*; D007672:Kidney Cortex / Q000201:enzymology; D007674:Kidney Diseases / Q000378:metabolism; D007679:Kidney Medulla / Q000201:enzymology; D007770:L-Lactate Dehydrogenase / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D006899:Mixed Function Oxygenases / Q000378:metabolism; D010088:Oxidoreductases / Q000378:metabolism; D044925:Oxidoreductases Acting on CH-CH Group Donors; D012156:Reticulocytes / Q000378:metabolism
D006454:Hemoglobins; D006418:Heme; D006899:Mixed Function Oxygenases; D010088:Oxidoreductases; D007770:L-Lactate Dehydrogenase; D044925:Oxidoreductases Acting on CH-CH Group Donors; C019789:biliverdin reductase; D001664:Biliverdine; D001663:Bilirubin