Antibiotic-loaded acrylic cement.
Laboratory experiments and clinical investigations have confirmed the various claims made originally by Buchholz and Engelbrecht (1970) that antibiotic-loaded acrylic cement releases the antibiotic into the surroundings in useful concentrations. Palacos R cement released higher concentrations than CMW, Simplex and Sulfix brands of cement and over longer periods. Concentrations of gentamycin and fucidin were sufficient to penetrate dead cortical bone. These conclusions need to be assessed with animal studies, mechanical testing and clinical results before the ideal place of antibiotic-loaded acrylic cement is established.
D000180:Acrylic Resins; D001419:Bacteria / Q000187:drug effects; D001702:Biopharmaceutics; D001843:Bone Cements; D001842:Bone and Bones / Q000032:analysis; D003692:Delayed-Action Preparations; D004058:Diffusion; D005672:Fusidic Acid / Q000008:administration & dosage / Q000032:analysis / Q000494:pharmacology*; D005839:Gentamicins / Q000008:administration & dosage / Q000032:analysis / Q000494:pharmacology*; D006621:Hip Joint / Q000601:surgery; D006801:Humans; D066298:In Vitro Techniques; D007595:Joint Prosthesis; D013530:Surgical Wound Infection / Q000517:prevention & control
D000180:Acrylic Resins; D001843:Bone Cements; D003692:Delayed-Action Preparations; D005839:Gentamicins; D005672:Fusidic Acid