title: Age-related changes in the hepatic endoplasmic reticulum: a quantitative analysis.
abstract: Morphometric analysis demonstrated a twofold increase in the surface area of the hepatic endoplasmic reticulum in Fischer 344 rats between 1 and 20 months of age, followed by a significant decrease in this parameter between 20 and 30 months. These changes are attributed to the smooth-surfaced endoplasmic reticulum, since neither the rough-surfaced variety nor the Golgi membranes underwent any significant change in surface area as a function of the age of the animal.
mesh_terms: D000375:Aging; D000818:Animals; D004721:Endoplasmic Reticulum / Q000648:ultrastructure*; D006056:Golgi Apparatus / Q000648:ultrastructure; D008099:Liver / Q000648:ultrastructure*; D008297:Male; D051381:Rats; D011916:Rats, Inbred F344