The participation of enteric inhibitory nerves in accommodation of the intestine to distension.
1. The amounts by which various weights distended isolated segments from the distal colons of guinea-pigs were measured. 2. Tetrodotoxin substantially reduced the distensibility of the intestine, but bretylium, guanethidine, hyoscine and methysergide had no significant effect. 3. It is concluded that a local reflex involving enteric inhibitory nerves causes an accomodation of the intestine to stretch.
D000818:Animals; D001950:Bretylium Tosylate / Q000494:pharmacology; D003106:Colon / Q000294:innervation* / Q000502:physiology; D005769:Gastrointestinal Motility / Q000187:drug effects; D006145:Guanethidine / Q000494:pharmacology; D006168:Guinea Pigs; D066298:In Vitro Techniques; D008784:Methysergide / Q000494:pharmacology; D009119:Muscle Contraction / Q000187:drug effects; D009433:Neural Inhibition; D012601:Scopolamine / Q000494:pharmacology; D013779:Tetrodotoxin / Q000494:pharmacology; D013997:Time Factors
D013779:Tetrodotoxin; D001950:Bretylium Tosylate; D012601:Scopolamine; D008784:Methysergide; D006145:Guanethidine