title: Antagonism of etonitazene's effects in rats and pigeons.
abstract: The effects of etonitazene were studied in the pigeon under a mult FR FI schedule of food presentation and in the rat under a continuous avoidance-escape schedule. A low dose of etonitazene increased rates of responding by pigeons under the FI component of the multiple schedule, whereas higher doses produced dose-related decreases in rates of responding under both components of the multiple schedule. These effects were blocked by cyclazocine. Under the continuous avoidance-escape schedule, etonitazene produced only dose-related decreases in rates of responding by rats, and these decreases were blocked by naloxone.
mesh_terms: D000818:Animals; D001362:Avoidance Learning / Q000187:drug effects*; D001562:Benzimidazoles / Q000037:antagonists & inhibitors*; D010856:Columbidae; D003216:Conditioning, Operant / Q000187:drug effects*; D003496:Cyclazocine / Q000494:pharmacology; D004048:Diethylamines / Q000037:antagonists & inhibitors; D004305:Dose-Response Relationship, Drug; D004338:Drug Combinations; D008297:Male; D009270:Naloxone / Q000494:pharmacology; D051381:Rats
chemical_list: D001562:Benzimidazoles; D004048:Diethylamines; D004338:Drug Combinations; D009270:Naloxone; D003496:Cyclazocine