[Effect of the anthracycline antineoplastic antibiotics, rubomycin and carminomycin, on the glycogen and nucleic acid content in the myocardium of white mice].
The effect of 2 anthracycline antibiotics, i.e. rubomycin and karminomycin on the content of glycogen, RNA and DNA in the cardiac muscle of albino mice was studied on their five-fold intravenous administration once every 5 days in equieffect doses by the lethal outcome. It was found that under the effect of the above antibiotics accumulation of glycogen in the cardiac muscle of mice took place, this was most pronounced in the animals treated with karminomycin in doses of 2.15 mg/kg. A decrease in the absolute content of RNA and DNA in the mouse heart after the first 4 administrations and in the ratio of RNA to DNA was observed as compared to the analogous values in the control animals at the account of a more intensive decrease in the content of RNA than that of DNA.
D000818:Animals; D000903:Antibiotics, Antineoplastic / Q000494:pharmacology*; D002360:Carubicin / Q000494:pharmacology*; D004247:DNA / Q000378:metabolism*; D003630:Daunorubicin / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D005260:Female; D006003:Glycogen / Q000378:metabolism*; D006321:Heart / Q000187:drug effects*; D051379:Mice; D009206:Myocardium / Q000378:metabolism*; D012313:RNA / Q000378:metabolism*; D013997:Time Factors
D000903:Antibiotics, Antineoplastic; D012313:RNA; D006003:Glycogen; D004247:DNA; D002360:Carubicin; D003630:Daunorubicin
Vliianie antratsiklinovykh protivoopukholevykh antibiotikov rubomitsina i karminomitsina na soderzhanie glikogena i nukleinovykh kislot v serdechnoĭ myshtse belykh mysheĭ.