title: The effect of heparin on the interaction of factor VIII and human platelets in vitro.
abstract: Heparin was found to inhibit the interaction between human factor VIII and platelets. This was noted in two different systems, namely, platelet aggregation induced by neuraminidase-treated human cryoprecipitate and platelet aggregation induced by ristocetin-human factor VIII complex. Heparin appeared to have an inhibitory effect on the above systems similar to that reported on bovine factor VIII-induced platelet aggregation.
mesh_terms: D001792:Blood Platelets / Q000378:metabolism*; D011232:Chemical Precipitation; D003450:Cryoglobulins; D005169:Factor VIII / Q000378:metabolism*; D006493:Heparin / Q000494:pharmacology*; D006801:Humans; D066298:In Vitro Techniques; D009439:Neuraminidase / Q000494:pharmacology; D010974:Platelet Aggregation / Q000187:drug effects; D012310:Ristocetin / Q000494:pharmacology
chemical_list: D003450:Cryoglobulins; D012310:Ristocetin; D005169:Factor VIII; D006493:Heparin; D009439:Neuraminidase