Analgesic effects of 3-carboxysalsolinol alone and in combination with morphine.
A biphasic dose-response pattern is generated by the isoquinoline, 3-carboxysalsolinol, in analgesia tests conducted in mice. Carbidopa pretreatment enhances this effect, as well as the morphine-induced analgesic increase by 3-carboxysalsolinol. Naloxone blockade of all of these responses suggests an interaction of the alcohol-based isoquinoline with central opiate receptors.
D000698:Analgesia; D000818:Animals; D002230:Carbidopa / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D004357:Drug Synergism; D007546:Isoquinolines / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D007980:Levodopa / Q000494:pharmacology; D051379:Mice; D009020:Morphine / Q000494:pharmacology*; D009270:Naloxone / Q000494:pharmacology; D012490:Salsoline Alkaloids
D007546:Isoquinolines; D012490:Salsoline Alkaloids; D009270:Naloxone; D007980:Levodopa; C011704:carboxysalsolinol; D009020:Morphine; D002230:Carbidopa