[Effect of the cholesterol breakdown rate in the body on the dynamics of the development of alimentary hypercholesterinemia in rabbits].
A mathematical equation of the shift of the dynamic balance of cholesterolemia to a new level is substantiated. A mathematical analysis of the results of experimental studies is presented. A correlation was established between the mechanism of the development of alimentary hypercholesterolemia in rabbits and the half-life period of cholesterol in the body (T1/2 per day). It is demonstrated that an equilibrium level of hypercholesterolemia (Xeqn,ch, mg%) is directly proportional to the speed of cholesterol accumulation in blood (Vch, mg%/day) and reciprocal to the constant rate of cholesterol decomposition in the body.
D000818:Animals; D002250:Carbon Radioisotopes; D002784:Cholesterol / Q000378:metabolism*; D002791:Cholesterol, Dietary / Q000008:administration & dosage; D004195:Disease Models, Animal; D004305:Dose-Response Relationship, Drug; D006207:Half-Life; D006937:Hypercholesterolemia / Q000209:etiology / Q000378:metabolism*; D008433:Mathematics; D008657:Metabolic Clearance Rate; D011817:Rabbits; D013997:Time Factors
D002250:Carbon Radioisotopes; D002791:Cholesterol, Dietary; D002784:Cholesterol
Vliianie skorosti raspada kholesterina v organizme na dinamiku razvitiia alimentarnoĭ giperkholesterinemii u krolikov