Structure-activity studies using valence molecular connectivity.
The extension of the molecular connectivity concept to the treatment of heteroatom molecules affords an opportunity to examine structure-activity relationships in a wide variety of molecule series that possess biological activity. Four series are described in this report. The correlations found indicate that molecular connectivity is an extremely useful descriptor of structure in studying drug molecule structure-activity relationships.
D000814:Aniline Compounds / Q000494:pharmacology; D000818:Animals; D001234:Aspergillus niger / Q000187:drug effects; D001592:Benzyl Alcohols / Q000494:pharmacology; D003580:Cytochromes / Q000378:metabolism; D004601:Elementary Particles; D006793:Houseflies / Q000187:drug effects; D066298:In Vitro Techniques; D008099:Liver / Q000187:drug effects / Q000201:enzymology; D009943:Organophosphorus Compounds / Q000494:pharmacology; D010636:Phenols / Q000494:pharmacology; D011817:Rabbits; D013329:Structure-Activity Relationship; D013649:Taste / Q000187:drug effects
D000814:Aniline Compounds; D001592:Benzyl Alcohols; D003580:Cytochromes; D009943:Organophosphorus Compounds; D010636:Phenols