Blood compatibility of methyl, methyl vinyl, methyl phenyl, and trifluoropropylmethylvinyl silicone rubber without silica fillers in the spiral-coiled membrane lung.
Spiral-coiled membrane lungs of 0.6 m2 surface area were fabricated from silicone rubber membranes coated with four types of commercially available pure-gum polysiloxane rubber: 1) polytrifluoropropylmethylvinylsiloxane, 2) polymethylphenylsiloxane, 3) polymethylvinylsiloxane, and 4) polydimethylsiloxane. Membranes lungs were tested in an arteriovenous shunt without added heparin after bypass was begun. All group 4 had major rise in resistance to blood flow or clotting in over 33% of the membrane lungs studied, after 6 hr of bypass. Membrane lungs with polydimethylsiloxane (group 4) had no rise in resistance to blood flow during 24 hr of bypass and had the least amount of changes in blood platelet count.
D000818:Animals; D001672:Biocompatible Materials; D001769:Blood; D001772:Blood Cell Count; D001777:Blood Coagulation; D004129:Dimethylpolysiloxanes; D008567:Membranes, Artificial; D010107:Oxygenators, Membrane; D011145:Polyvinyls; D012756:Sheep; D012826:Silicone Elastomers; D012828:Silicones; D012833:Siloxanes; D014655:Vascular Resistance
D001672:Biocompatible Materials; D004129:Dimethylpolysiloxanes; D008567:Membranes, Artificial; D011145:Polyvinyls; D012826:Silicone Elastomers; D012828:Silicones; D012833:Siloxanes; C014768:polytrifluoropropylmethylvinylsiloxane; C014763:polymethylphenylsiloxane; C014766:polymethylvinylsiloxane