Role of rate of change of glucose concentration as a signal for insulin release.
In the isolated perfused pancreas, the amount of insulin secreted in response to a glucose stimulus was evaluated as a function of the maximum rate of change of the stimulus. Range of glucose concentration, total amount of glucose, total duration of the changing stimulus, the average concentration, and the average rate of change of concentration were the same. Fast changes stimulated more insulin secretion than slow changes, indicating that the rate-sensor property was inherent in the control of insulin release.
D000818:Animals; D004305:Dose-Response Relationship, Drug; D005947:Glucose / Q000008:administration & dosage / Q000494:pharmacology*; D007328:Insulin / Q000378:metabolism*; D000078790:Insulin Secretion; D010179:Pancreas / Q000187:drug effects / Q000378:metabolism*; D051381:Rats; D013997:Time Factors
D007328:Insulin; D005947:Glucose