Decidual extracts suppress antibody response in vitro.
Extracts of decidual tissue produced in pseudopregnant rats were found to suppress in vitro antibody response to alpha-2,4-dinitrophenyl-polylysine. The peak levels of both the total antibody response and the 2-mercaptoethanol-resistant fraction were reduced. Extracts prepared in a similar manner from uteri of normal untreated or pseudopregnant rats did not exert such an effect.
D000818:Animals; D000917:Antibody Formation; D003656:Decidua / Q000276:immunology*; D004136:Dinitrobenzenes / Q000276:immunology; D005260:Female; D007166:Immunosuppressive Agents; D008623:Mercaptoethanol / Q000494:pharmacology; D011247:Pregnancy; D011270:Pregnancy, Animal; D051381:Rats; D014020:Tissue Extracts / Q000494:pharmacology*
D004136:Dinitrobenzenes; D007166:Immunosuppressive Agents; D014020:Tissue Extracts; D008623:Mercaptoethanol