Effects of gestational age, birth weight, and hypoxemia on pharmacokinetics of amikacin in serum of infants.
The serum pharmacokinetics of amikacin were studied in 36 infants treated for suspected bacterial infection. A prolonged serum half-life was associated with the related variables of birth at an early gestational age, low birth weight, and hypoxemia. A postnatal age effect was not apparent when hypoxemic infants were excluded.
D000583:Amikacin / Q000097:blood*; D001424:Bacterial Infections / Q000097:blood*; D001724:Birth Weight; D005260:Female; D005865:Gestational Age; D006801:Humans; D000860:Hypoxia / Q000097:blood*; D007231:Infant, Newborn; D007232:Infant, Newborn, Diseases / Q000097:blood*; D007612:Kanamycin / Q000031:analogs & derivatives*; D008297:Male
D007612:Kanamycin; D000583:Amikacin