Production and antibacterial activity of malforming C, a toxic metabolite of Aspergillus niger.
The production of the new mycotoxin malformin C by a solid substrate fermentation is described. Malformin C is highly toxic (mean lethal dose = 0.9 mg/kg) and exerts antibacterial activity against a variety of gram-positive and gram-negative organisms.
D001230:Aspergillus / Q000378:metabolism*; D001234:Aspergillus niger / Q000378:metabolism*; D001419:Bacteria / Q000187:drug effects; D002523:Edible Grain / Q000382:microbiology; D005285:Fermentation; D009183:Mycotoxins / Q000096:biosynthesis* / Q000494:pharmacology; D013045:Species Specificity
D009183:Mycotoxins