2,6-dialkylpiperazines. VIII (1)-N1-arylalkyl-N4-(2'-pyridyl)-2,6-dimethylpiperazines as adrenolytic and vasodilator agents.
A series of cis and trans N1-arylalkyl-N4-(2'-pyridyl)-2'6-dimethylpiperazines were synthetized and tested as adrenolytic and vasodilator agents. The N1-substitution with the 3,4-dimethoxyphenethyl group seems the most promising with regard to pharmacological activity, which was found to reside mainly in the trans isomer (3-II b). The adrenolytic activity of (3-II b) is comparable with that of the related 2-methyl derivative (1-III), while it is higher than that of (IV) in which the piperazine nucleus is C-unsubstituted.
D000818:Animals; D002415:Cats; D055598:Chemical Phenomena; D002621:Chemistry; D007536:Isomerism; D008297:Male; D051379:Mice; D010879:Piperazines / Q000138:chemical synthesis*; D051381:Rats; D013565:Sympatholytics / Q000138:chemical synthesis*; D014665:Vasodilator Agents / Q000138:chemical synthesis*
D010879:Piperazines; D013565:Sympatholytics; D014665:Vasodilator Agents