Asymmetric depression in the serum level of IgG subclasses in patients with nephrotic syndrome.
Thirty-three nephrotic patients were studied for IgG-subclass levels in matched pairs of serum and urinary specimens. Levels in the serum were compared with those found in the sera of non-nephrotic control children and normal adults. Results have shown an asymmetric depression in the serum level of certain IgG subclasses in some patients with minimal-change nephrotic syndrome, focal glomerulosclerosis, and proliferative glomerulonephritis, indicating that the urinary loss of IgG alone cannot account for the low blood levels of this immunoglobulin class in these conditions.
D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D005921:Glomerulonephritis / Q000276:immunology; D006801:Humans; D007074:Immunoglobulin G / Q000032:analysis* / Q000652:urine; D009404:Nephrotic Syndrome / Q000276:immunology*
D007074:Immunoglobulin G