Selective inhibition of the "B form" of monoamine oxidase.
Deprenyl (phenyl-isopropyl-methyl-propinylamine) is a potent inhibitor of monoamine oxidase (MAO) and like the acetylenic type of inhibitors it induces irreversible inhibition of the enzyme. Its levorotatory isomer is a more potent inhibitor than the dextrorotatory one. Deprenyl elevates the concentration of 3H-noradrenaline (3H-NA) in the synaptosomal fraction of rat heart homogenate while pargyline, probably due to its releasing effect, decreases 3H-NA content in the same fraction. Deprenyl is a selective inhibitor of the "B form" of MAO, which preferentially oxidizes beta-phenylethylamine as substrate.
D000818:Animals; D001921:Brain / Q000166:cytology / Q000187:drug effects; D055598:Chemical Phenomena; D002621:Chemistry; D003641:Deamination; D006321:Heart / Q000187:drug effects; D008297:Male; D008930:Mitochondria, Liver / Q000187:drug effects; D008996:Monoamine Oxidase Inhibitors / Q000494:pharmacology*; D010627:Phenethylamines / Q000494:pharmacology*; D051381:Rats; D013329:Structure-Activity Relationship
D008996:Monoamine Oxidase Inhibitors; D010627:Phenethylamines