Phalloidin poisoning of isolated hepatocytes: inhibition of protein synthesis.
Phalloidin added to isolated hepatocytes inhibits amino acid incorporation into protein. Inhibition is very strong with 20 micrograms/ml phalloidin and occurs after a lag period of about 30 min. After this period, poisoned hepatocytes also show morphological changes in their plasma membrane.
D000818:Animals; D066298:In Vitro Techniques; D007700:Kinetics; D008099:Liver / Q000378:metabolism*; D009842:Oligopeptides / Q000494:pharmacology*; D010590:Phalloidine / Q000494:pharmacology*; D014176:Protein Biosynthesis / Q000187:drug effects*; D051381:Rats
D009842:Oligopeptides; D010590:Phalloidine