[Study on cephaloridine concentration in bone marrow (author's transl)].
Cephaloridine (CER) concentration in the bone marrow of tibia was examined 1, 2, and 3 hours after intramuscular injection of 1 g. CER concentration in the bone marrow of tibia 1 hour after injection was 26.0+/-8.927 microng/ml. Ratio to serum was 78.5%. CER concentration in the bone marrow of tibia 2 hours after injection was 20.6+/-5.003 microng/ml. Ratio to serum was 87.3%. CER concentration of bone marrow of tibia 3 hours after injection was 14.8+/-4.79 microng/ml. Ratio to serum was 91.9%. Difference of concentration between in bone marrow and serum was not statistically significant. Penetration capacity of CER into the bone marrow of tibia was excellent.
D000293:Adolescent; D000328:Adult; D001853:Bone Marrow / Q000378:metabolism*; D002509:Cephaloridine / Q000008:administration & dosage / Q000097:blood / Q000378:metabolism*; D006801:Humans; D007273:Injections, Intramuscular; D008297:Male; D008875:Middle Aged
D002509:Cephaloridine