title: Sympathetic inhibition of thermogenesis in the infant rat: possible glucostatic control.
abstract: Nonshivering thermogenesis (NST) was examined during cold exposure (30 degrees C) in 5-day-old rats, during food deprivation. NST in the fed state doubled the O2 consumption observed at neutral temperatures. With fasting, the additional O2 consumption stimulated by cold dropped to that observed at thermoneutrality within 6 h, and colonic temperature (Tco) dropped concomitantly. Blood glucose (BG) concentration was halved. Oxygen consumption and Tco in the cold varied linearly with BG changes during food deprivation. 6-Hydroxydopamine transiently stimulated norepinephrine release and elevated metabolism nonadditively with cold stimulation in fed animals, and also stimulated O2 consumption. The drug also partially restored BG concentration, after it had declined during fasting. NST and BG were also restored by gastric infusion of glucose. These data suggest that the decline of NST, and the subsequent hypothermia during food deprivation, is in large part a sympathetically mediated reflex response to low cerebral BG concentration. However, glucose injection in doses sufficient to restore BG after fasting did not restore NST, nor was NST abolished by intracellular glucoprivation with 2-deoxy-D-glucose in fed rats. Thus, it is not argued that BG concentration is in itself an adequate signal for controlling NST.
mesh_terms: D000818:Animals; D000831:Animals, Newborn; D001786:Blood Glucose / Q000378:metabolism; D001831:Body Temperature; D001833:Body Temperature Regulation; D003080:Cold Temperature; D003847:Deoxyglucose / Q000494:pharmacology; D005215:Fasting; D005934:Glucagon / Q000494:pharmacology; D005947:Glucose / Q000494:pharmacology; D006892:Hydroxydopamines / Q000494:pharmacology; D007328:Insulin / Q000494:pharmacology; D008112:Liver Glycogen / Q000378:metabolism; D010101:Oxygen Consumption / Q000187:drug effects; D051381:Rats; D012110:Reserpine / Q000494:pharmacology
chemical_list: D001786:Blood Glucose; D006892:Hydroxydopamines; D007328:Insulin; D008112:Liver Glycogen; D012110:Reserpine; D005934:Glucagon; D003847:Deoxyglucose; D005947:Glucose