Fine structure of the cerebellum of "staggerer-reeler", a double mutant of mice affected by staggerer and reeler conditions. III. bergmann fiber anomalies.
Bergmann fibers and the distribution of Golgi epithelial cells were significantly altered in staggerer, reeler and double mutant (affected by both staggerer and reeler conditions). However, the Bergmann fiber anomalies in double mutant were not identical to those of either staggerer or reeler. A comparison of these anomalies with the anomalies described in weaver revealed that the developmental patterns of Bergmann fibers are distinct in all four cerebellar mutants just as are the cytoarchitectural anomalies of these cerebella. The results of the present electronmicroscopic examinations of Bergmann fibers in staggerer and reeler were in good agreement with the findings made with the immunofluorescence technique. There was, however, one important discrepancy between these two sets of observations. Immunofluorescent astrocytic fibers were nearly absent in 21 and 26 day old staggerers while Bergmann fibers were structurally present in nearly normal numbers both at days 21 and 31. A possible reason for this discrepancy was discussed.
D000367:Age Factors; D000818:Animals; D002526:Cerebellar Diseases / Q000235:genetics* / Q000473:pathology; D002531:Cerebellum / Q000648:ultrastructure*; D004525:Efferent Pathways / Q000648:ultrastructure*; D051379:Mice; D008815:Mice, Inbred Strains; D009154:Mutation; D009457:Neuroglia / Q000648:ultrastructure