title: Potential anticancer agents. IV. Constituents of Jacaranda caucana Pittier (Bignoniaceae).
abstract: An aqueous ethanol extract of Jacaranda caucana Pittier (Bignoniaceae) showed in vivo antitumor activity against the P-388 lymphocytic leukemia system. Fractionation, accompanied by monitoring for biological activity, afforded a novel phytoquinoid derivative jacaranone, which exhibited both in vivo antitumor and in vitro cytotoxic activity. beta-Sitosterol, betulinic acid, ursolic acid, 2alpha-hydroxyursolic acid, 2alpha,3alpha-dihydroxyurs-12-en-28-oic acid and a new triterpene acid, jacarandic acid, were also isolated. The structure elucidation of jacarandic acid is described.
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000302:isolation & purification*; D001681:Biological Assay; D010946:Plants, Medicinal / Q000032:analysis*; D011809:Quinones / Q000302:isolation & purification; D014197:Trees; D014315:Triterpenes / Q000302:isolation & purification
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D011809:Quinones; D014315:Triterpenes