EEG and extracelluar K+ in rat brain during pentylenetetrazol seizures and during respiratory arrest.
The relationship between changes in EEG and the extracellular potassium concentration (K+e) in brain cortex was studied in rats during petylenetetrazol seizures and during respiratory arrest. During seizures an increase of K+e occurred subsequent to the electrical discharges, while during postictal depression of EEG normal levels of K+e were measured. During respiratory arrest K+e rose considerably one minute after flattering of EEG. These findings are against a concept of K+e determining the changes of the EEG pattern. It is hypothetized that during seizures the increased K+e may play an important role in the coupling of neuronal activity to cerebral blood flow and metabolism.
D000818:Animals; D001049:Apnea / Q000378:metabolism* / Q000503:physiopathology*; D001921:Brain / Q000378:metabolism* / Q000503:physiopathology; D004569:Electroencephalography; D005110:Extracellular Space / Q000378:metabolism; D008297:Male; D010433:Pentylenetetrazole; D011188:Potassium / Q000378:metabolism*; D051381:Rats; D012640:Seizures / Q000139:chemically induced / Q000378:metabolism* / Q000503:physiopathology
D011188:Potassium; D010433:Pentylenetetrazole