Mechanisms of resistance to aminoglycosides.
Bacterial resistance to aminoglycoside antibiotics occurs by a variety of mechanisms. In clinical situations the most common mechanism is plasmid-determined modification of the drug that leads to a block of transport of the antibiotic into the cell. Amikacin, a semisynthetic aminoglycoside, is effective against a number of resistant strains because it has fewer sites of modification.
D000583:Amikacin; D000613:Aminobutyrates; D000617:Aminoglycosides / Q000494:pharmacology*; D001665:Binding Sites; D055598:Chemical Phenomena; D002621:Chemistry; D004352:Drug Resistance, Microbial; D006885:Hydroxybutyrates; D010957:Plasmids; D012270:Ribosomes; D013329:Structure-Activity Relationship
D000613:Aminobutyrates; D000617:Aminoglycosides; D006885:Hydroxybutyrates; D000583:Amikacin