Influence of HLA-A2 on the effectiveness of platelet transfusions in alloimmunized thrombocytopenic patients.
Platelet transfusions from donors selectively mismatched for cross-reactive and certain non-cross-reactive HLA antigens were found to be more effective in HLA-A2 negative than in HLA-A2 positive, alloimmunized thrombocytopenic patients. The two groups of patients responded equally well to platelets matched for antigens of the HLA-A and B loci. Certain alloimmunized patients negative for HLA-A2 continued to respond satisfactorily to platelets selectively mismatched for non-cross-reactive HLA antigens as long as platelets containing HLA-A2 were avoided. The data indicate that platelet transfusion support can be provided within a broader range of donor-recipient HLA antigenic disparity to HLA-A2 negative alloimmunized patients than to those who are positive for this antigen.
D000918:Antibody Specificity; D001792:Blood Platelets; D001803:Blood Transfusion; D003429:Cross Reactions; D006680:HLA Antigens; D006649:Histocompatibility Antigens; D006801:Humans; D007114:Immunization; D007518:Isoantibodies; D013921:Thrombocytopenia / Q000628:therapy*
D006680:HLA Antigens; D006649:Histocompatibility Antigens; D007518:Isoantibodies