[Directed attacks on the specific activity of leukemia cells].
Different means of attenuating the leukemogenic activity were studied comparatively with a continuous strain of bone marrow cells derived from mice infected with Rauscher leukemia virus. Treatment of leukemic cells with neuraminidase, like their cultivation at suboptimal temperature resulted in a complete loss of leukemogenic activity, as evidenced by 100% survival of experimental animals and the absence of splenomegaly. In parallel experiments with concanavallin A and 5-bromdeoxyuridine treatment, development of splenomegaly was retarded and lethality of the animals reduced by 70 and 20%, rnd 20%, respectively. These results permit to raise the problem of using the above-memtioned methods for the attenuation of leukemogenic activity as an approach to prepare material with the immunizing activity.
D000818:Animals; D001973:Bromodeoxyuridine / Q000627:therapeutic use; D002478:Cells, Cultured; D003208:Concanavalin A / Q000627:therapeutic use; D007942:Leukemia, Experimental / Q000628:therapy*; D051379:Mice; D008807:Mice, Inbred BALB C; D009368:Neoplasm Transplantation; D009439:Neuraminidase / Q000627:therapeutic use; D011925:Rauscher Virus; D013696:Temperature
D003208:Concanavalin A; D009439:Neuraminidase; D001973:Bromodeoxyuridine
Napravlennye vozdeĭstviia na spetsificheskuiu aktivnost' lekoznykh kletok