The effects of prostaglandin E1, bradykinin and histamine on canine synovial vascular permeability.
1 The relative effects of prostaglandin E1, bradykinin and histamine on canine synovial vascular permeability were investigated by a method based on the measurement of the amounts of radiolabelled dextran (molecular weight 20,000) leaking from the circulation into the synovial cavity. 2 Bradykinin, prostaglandin E1 and histamine in that order of potency all increased synovial vascular permeability. Threshold concentrations were 0.3 micrometer, 3 micrometer and 30 micrometer respectively. 3 The effects of infusion of prostaglandin E1 combined with either bradykinin or histamine were greater than mere summation.
D000818:Animals; D001920:Bradykinin / Q000494:pharmacology*; D002199:Capillary Permeability / Q000187:drug effects*; D003911:Dextrans; D004285:Dogs; D004347:Drug Interactions; D006632:Histamine / Q000494:pharmacology*; D011458:Prostaglandins E / Q000494:pharmacology*; D013583:Synovial Membrane / Q000098:blood supply*
D003911:Dextrans; D011458:Prostaglandins E; D006632:Histamine; D001920:Bradykinin