[Effect of euphylline and halidor on several indices of catecholamine and serotonin metabolism in the brains and blood of rats].
Euphylline and galidore did not alter the concentration of catecholamines and serotonin in brain of intact rats, but exhibited opposite effects on metabolism of biogenic amines, if their precursors were administered into animals. Galidore decreased the activity of catechol-O-methyl transferase (COMT) and 5-hydroxytryptophane decarboxylase. Euphylline did not influence the COMT activity but increased the activity of 5-HT-decarboxylase. Both preparations did not alter the monoaminooxidase activity.
D000628:Aminophylline / Q000494:pharmacology*; D000818:Animals; D065105:Aromatic Amino Acid Decarboxylase Inhibitors; D001537:Bencyclane / Q000494:pharmacology*; D001921:Brain / Q000201:enzymology / Q000378:metabolism*; D002394:Catechol O-Methyltransferase / Q000378:metabolism; D065098:Catechol O-Methyltransferase Inhibitors; D002395:Catecholamines / Q000378:metabolism*; D003508:Cycloheptanes / Q000494:pharmacology*; D004295:Dihydroxyphenylalanine / Q000378:metabolism; D004296:Dopa Decarboxylase / Q000378:metabolism; D004298:Dopamine / Q000378:metabolism; D004837:Epinephrine / Q000378:metabolism; D005260:Female; D008297:Male; D051379:Mice; D008995:Monoamine Oxidase / Q000378:metabolism; D009638:Norepinephrine / Q000378:metabolism; D051381:Rats; D012701:Serotonin / Q000378:metabolism*; D014665:Vasodilator Agents / Q000494:pharmacology*
D065105:Aromatic Amino Acid Decarboxylase Inhibitors; D065098:Catechol O-Methyltransferase Inhibitors; D002395:Catecholamines; D003508:Cycloheptanes; D014665:Vasodilator Agents; D000628:Aminophylline; D012701:Serotonin; D004295:Dihydroxyphenylalanine; D001537:Bencyclane; D008995:Monoamine Oxidase; D002394:Catechol O-Methyltransferase; D004296:Dopa Decarboxylase; D004298:Dopamine; D009638:Norepinephrine; D004837:Epinephrine
Vliianie éufillina i galidora na nekotorye pokazateli obmena katekholaminov i serotonina v mozge i krovi krys.