Cephalosporin degradations.
The acidic aqueous degradation of the 7alpha-aminophenylglycinamido-containing cephalosporin cephalexin (1a) has been examined. Two major degradation products have been isolated and characterized: 3-formyl-3,6-dihydro-6-phenyl-2.5(1H,4H)-pyrazinedione (5) and 3-hydroxy-4-methyl-2(5H)-thiophenone (6). By carrying out the reaction in 18O-enriched H2O, the intramolecular nature of the cephalexin degradation has been demonstrated.
D000818:Animals; D002506:Cephalexin; D002511:Cephalosporins / Q000032:analysis / Q000633:toxicity; D055598:Chemical Phenomena; D002621:Chemistry; D005260:Female; D006868:Hydrolysis; D009682:Magnetic Resonance Spectroscopy; D051379:Mice; D008813:Mice, Inbred ICR
D002511:Cephalosporins; D002506:Cephalexin