Dopamine receptor binding enhancement accompanies lesion-induced behavioral supersensitivity.
The binding of [3H]haloperidol to rat striatal dopamine receptors increases after lesion (made by injection of 6-hydroxydopamine) of the nigrostriatal dopamine pathway in those rats which are behaviorally supersensitive, as reflected by apomorphine-induced contralateral rotations. The enhanced binding is associated with an increased number of receptor sites with no change in their affinity.
D000818:Animals; D001058:Apomorphine / Q000494:pharmacology; D001522:Behavior, Animal / Q000187:drug effects*; D003342:Corpus Striatum / Q000187:drug effects* / Q000378:metabolism; D004298:Dopamine / Q000378:metabolism; D006220:Haloperidol / Q000378:metabolism*; D006892:Hydroxydopamines / Q000494:pharmacology*; D007700:Kinetics; D009043:Motor Activity / Q000187:drug effects; D051381:Rats; D011954:Receptors, Dopamine / Q000187:drug effects* / Q000378:metabolism; D012110:Reserpine / Q000494:pharmacology
D006892:Hydroxydopamines; D011954:Receptors, Dopamine; D012110:Reserpine; D006220:Haloperidol; D001058:Apomorphine; D004298:Dopamine