Modification by indomethacin of the blood pressure lowering effect of pindolol and propranolol in conscious rabbits.
In conscious rabbits, the intravenous administration of pindolol (0.125 mg/kg) and propranolol (1 mg/kg) induced a highly significant (p less than 0.001) decrease of mean arterial blood pressure and with propranolol, a significant (p less than 0.01) bradycardia. In the same model the intravenous administrtion of saline (1 ml/kg) and of indomethacin (1 mg/kg) did not affect mean arterial blood pressure or heart rate (p greater than 0.3). Pretreatment of the animals with indomethacin (1 mg/kg) abolished the effect of both beta-blockers on mean arterial blood pressure (p greater than 0.05) and had no significant effect on heart rate.
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects*; D006339:Heart Rate / Q000187:drug effects; D007213:Indomethacin / Q000494:pharmacology*; D008297:Male; D010869:Pindolol / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D011433:Propranolol / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D011817:Rabbits; D013997:Time Factors
D011433:Propranolol; D010869:Pindolol; D007213:Indomethacin