title: [Glucose-6-phosphate dehydrogenase in rat liver and myocardium following toxic doses of noradrenaline].
abstract: Administration of toxic doses of noradrenaline into rats led to exhaustion of noradrenaline reserves in liver and heart tissues with the simultaneous increase in the activity of glucose-6-phosphate dehydrogenase in the tissues. Actinomycin D, administered together with noradrenaline, completely prevented the elevation of the G6PD activity in the tissues studied. The data obtained suggest that sympathetic nervous system and its mediator are responsible for regulation of the rate of enzymatic protein synthesis in tissues.
mesh_terms: D000818:Animals; D056486:Chemical and Drug Induced Liver Injury / Q000201:enzymology*; D005954:Glucosephosphate Dehydrogenase / Q000378:metabolism*; D006321:Heart / Q000187:drug effects; D008099:Liver / Q000187:drug effects / Q000201:enzymology*; D008297:Male; D009206:Myocardium / Q000201:enzymology*; D009638:Norepinephrine / Q000506:poisoning*; D051381:Rats
chemical_list: D005954:Glucosephosphate Dehydrogenase; D009638:Norepinephrine
vernacular_title: Gliukozo-6-fosfatdegidrogenazy pecheni i serdechnoĭ myshtsy krys pri vvedenii toksicheskikh doz noradrenalina.