title: Platelet function tests during major operation for gastro-intestinal carcinoma.
abstract: Platelet function tests were performed on 15 patients undergoing major operation preoperatively, during anaesthesia and 30 minutes and 3 hours after the beginning of operation. It was found that during anaesthesia platelet retention in a glass bead column and platelet aggregation were slightly reduced. During operation the bleeding time and the delay period of the collagen-induced aggregation were progressively prolonged, and the aggregation induced by ADP at a final concentration of 1 and 2 micrometer and by adrenaline was progressively reduced.
mesh_terms: D000328:Adult; D000368:Aged; D001772:Blood Cell Count; D001780:Blood Coagulation Tests; D001792:Blood Platelets; D003094:Collagen / Q000494:pharmacology; D004837:Epinephrine / Q000494:pharmacology; D005260:Female; D005770:Gastrointestinal Neoplasms / Q000601:surgery*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010974:Platelet Aggregation / Q000187:drug effects; D013997:Time Factors
chemical_list: D003094:Collagen; D004837:Epinephrine