Styrene and acrylonitrile induced depression of hepatic nonprotein sulfhydryl content in various rodent species.
Adult female mice, male rats, female hamsters and male guinea pigs received various doses of styrene (150-1000 mg/kg of body weight) and acrylonitrile (20-80 mg/kg of body weight) intraperitoneally. Both styrene and acrylonitrile caused a depression of the hepatic nonprotein sulfhydryl content. Mouse was the most vulnerable and rat the most resistant species to the effect of both of these two important plastic monomers.
D000181:Acrylonitrile / Q000494:pharmacology*; D000818:Animals; D006224:Cricetinae; D003864:Depression, Chemical; D005260:Female; D006168:Guinea Pigs; D008099:Liver / Q000187:drug effects / Q000378:metabolism*; D008297:Male; D008647:Mesocricetus; D051379:Mice; D009570:Nitriles / Q000494:pharmacology*; D051381:Rats; D013045:Species Specificity; D013343:Styrenes / Q000494:pharmacology*; D013438:Sulfhydryl Compounds / Q000378:metabolism*; D013997:Time Factors
D009570:Nitriles; D013343:Styrenes; D013438:Sulfhydryl Compounds; D000181:Acrylonitrile