Failure of cycloheximide to alter rate of recovery of temperature following acute DFP treatment.
Cycloheximide, 400 microgram intraventricularly 4 h after a 1 mg/kg i.m. injection of the irreversible anticholinesterase DFP, failed to alter the rate of recovery of temperature to normal. Tolerance to the hypothermic effects of DFP developed at the same rate in cycloheximide-treated rats. These findings suggest that neither recovery from the acute effects of DFP nor tolerance to its chronic effects depends on protein synthesis.
D000818:Animals; D001286:Atropine Derivatives / Q000494:pharmacology; D001831:Body Temperature / Q000187:drug effects*; D003513:Cycloheximide / Q000494:pharmacology*; D004347:Drug Interactions; D004361:Drug Tolerance; D007531:Isoflurophate / Q000008:administration & dosage / Q000494:pharmacology*; D008297:Male; D010862:Pilocarpine / Q000494:pharmacology; D051381:Rats; D013997:Time Factors
D001286:Atropine Derivatives; D010862:Pilocarpine; D007531:Isoflurophate; D003513:Cycloheximide