Lower limb paralysis induced in mice by a temperature-sensitive mutant of Moloney leukemia virus.
A temperature-sensitive mutant of Moloney murine leukemia virus defective in an early function and injected into newborn mice produced lower limb paralysis. Susceptible mice were inbred strains CFW/D, CBA/H, C3H/Bi/Ka, and outbred NIH Swiss stock. Inbred W/Fu rats and C57BL/Ka mice did not develop the paralysis, though the latter were infected with virus; the sera from these mice produced paralysis in susceptible CFW mice.
D000818:Animals; D000831:Animals, Newborn; D003673:Defective Viruses / Q000302:isolation & purification; D005121:Extremities; D051379:Mice; D008809:Mice, Inbred C3H; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D008815:Mice, Inbred Strains; D008979:Moloney murine leukemia virus / Q000302:isolation & purification / Q000472:pathogenicity*; D009154:Mutation; D010243:Paralysis / Q000209:etiology* / Q000382:microbiology / Q000473:pathology; D051381:Rats; D011920:Rats, Inbred WF; D013116:Spinal Cord / Q000648:ultrastructure; D013696:Temperature; D014412:Tumor Virus Infections / Q000473:pathology*