Proliferation characteristics of erythroblasts in chronic renal failure.
Proliferation of bone marrow erythroblasts in patients with chronic renal disease was studied by combined application of cytophotometric measurement of the DNA content and 3H-TdR labeling in vitro. A striking decrease of 3H-TdR labeling was found in most of the cases. The proportion of diploid (G0 + G1) as well as of tetraploid unlabeled cells (G2) was increased. The data suggest a disturbed induction of DNA synthesis of resting cells as well as an arrest of cells in G2 being responsable for ineffective cell production in this disease.
D000328:Adult; D000368:Aged; D001345:Autoradiography; D001853:Bone Marrow; D001854:Bone Marrow Cells; D002455:Cell Division; D004171:Diploidy; D004900:Erythroblasts; D004912:Erythrocytes; D005260:Female; D006801:Humans; D007676:Kidney Failure, Chronic / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D010783:Photometry; D011123:Polyploidy