title: Evidence for androgen participation in induced ovulation in immature rats.
abstract: Rabbit antiserum to testosterone injected intravenously (iv) together with 10 IU human chorionic gonadotropin (hCG) markedly reduced the number of tubal ova in intact or hypophysectomized immature rats primed with 5 IU pregnant mare's serum gonadotropin. Normal rabbit serum (NRS) injected instead of the antiserum resulted in a normal complement of ovulated ova. Ten microgram of testosterone or 5alpha-dihydrotestosterone dissolved in NRS administered iv 1 h after simultaneous injection of hCG and antiserum to progesterone (anti-P) restored ovulation that would otherwise have been blocked by anti-P, with a comparable number of ova to control animals not given anti-P. The results indicate active participation of androgen in induced ovulation in immature rats.
mesh_terms: D000818:Animals; D006063:Chorionic Gonadotropin / Q000494:pharmacology*; D013196:Dihydrotestosterone / Q000494:pharmacology; D004958:Estradiol / Q000494:pharmacology; D005260:Female; D006064:Gonadotropins, Equine / Q000494:pharmacology*; D007106:Immune Sera / Q000494:pharmacology; D010060:Ovulation / Q000187:drug effects*; D011374:Progesterone / Q000276:immunology; D051381:Rats; D012741:Sexual Maturation; D013739:Testosterone / Q000276:immunology / Q000494:pharmacology*
chemical_list: D006063:Chorionic Gonadotropin; D006064:Gonadotropins, Equine; D007106:Immune Sera; D013196:Dihydrotestosterone; D013739:Testosterone; D011374:Progesterone; D004958:Estradiol