title: In situ observation of dense-body release from hydrated human platelets.
abstract: Human-platelet dense bodies (secretory granules) have been visualized by electron microscopy in cells maintained in a hydrated state, and their sequential release after stimulation by thrombin has been observed in situ. The pattern of dense body release from individual platelets suggests that a a portion of the dense body complement of a single cell can be extruded without appreciable change in the position of the remaining dense bodies.
mesh_terms: D001792:Blood Platelets / Q000187:drug effects / Q000648:ultrastructure*; D006801:Humans; D066298:In Vitro Techniques; D013268:Stimulation, Chemical; D013696:Temperature; D013917:Thrombin / Q000494:pharmacology
chemical_list: D013917:Thrombin