Further toxicologic studies with commercial and candidate flame retardant chemicals. Part II.
A number of commercial and candidate flame retardants were studied with regard to their toxicity to goldfish, inhibition of cholinesterase, inhibition of acetyl choline binding to its receptor and insecticidal properties. Several of the flame retardants were notably toxic to fish. Some of the compounds showed modest inhibition of cholinesterase and/or microsomal oxidases, but none inhibited acetyl choline receptor binding. Whereas several of the flame retardants showed little or no insecticidal properties when added alone to a housefly diet, piperonyl butoxide greatly synergised their toxicity to houseflies.
D000109:Acetylcholine / Q000378:metabolism; D000814:Aniline Compounds; D000818:Animals; D002800:Cholinesterase Inhibitors; D004557:Electric Organ / Q000201:enzymology / Q000378:metabolism; D005390:Fires / Q000517:prevention & control*; D005399:Fishes; D006054:Goldfish; D006793:Houseflies / Q000187:drug effects*; D006842:Hydrocarbons, Brominated / Q000494:pharmacology / Q000633:toxicity; D066298:In Vitro Techniques; D007313:Insecta / Q000187:drug effects / Q000201:enzymology; D007928:Lethal Dose 50; D008861:Microsomes / Q000201:enzymology; D009943:Organophosphorus Compounds / Q000494:pharmacology / Q000633:toxicity*; D010089:Oxidoreductases, N-Demethylating / Q000037:antagonists & inhibitors; D011950:Receptors, Cholinergic / Q000378:metabolism
D000814:Aniline Compounds; D002800:Cholinesterase Inhibitors; D006842:Hydrocarbons, Brominated; D009943:Organophosphorus Compounds; D011950:Receptors, Cholinergic; D010089:Oxidoreductases, N-Demethylating; D000109:Acetylcholine