Tumor-associated lymphoid cells: analysis of host cells that bind to syngeneic and allogeneic tumor cells shortly after tumor administration.
A single intraperitoneal injection of irradiated EL-4 leukemia into syngeneic hosts induced in vivo immunity and in vitro cell-mediated response against EL-4. A nonadherent, theta-positive, peritoneal exudate lymphocyte fraction that bound to and lysed EL-4 in vitro was isolated from the tumor site. This system allowed the study of immune processes involving host lymphocytes as early as 3 days after tumor inoculation.
D000818:Animals; D001665:Binding Sites; D002471:Cell Transformation, Neoplastic; D003601:Cytotoxicity Tests, Immunologic; D007942:Leukemia, Experimental / Q000276:immunology*; D008214:Lymphocytes / Q000276:immunology*; D051379:Mice; D008806:Mice, Inbred AKR; D008807:Mice, Inbred BALB C; D008809:Mice, Inbred C3H; D008810:Mice, Inbred C57BL