Why does kidney size change during I.V. urography?
Meglumine iothalamate (280 ml I/ml) and sodium iothalamate (400 mg I/ml) in doses of 700 mg I/kg bw, were injected i.v. as a bolus in dogs. Renal size, urine flow rate, arterial pressure, renal blood flow and mean transit time and renal blood volume were measured before and after injection. All changes were qualitatively and quantitatively identical for both drugs. They produced a small transient renal shrinkage followed by a greater and prolonged renal enlargement. During the period of renal enlargement, urine flow increased. The time course of the enlargement paralleled the increase of urine flow rate. Renal blood flow also increased but both the mean transit time and renal vascular volume decreased. Therefore, the kidney size increase after i.v. injection of large doses of urographic contrast media cannot be attributed to an increased volume of the vessels. Most likely it is caused by diuresis-induced increase in the volume of the tubules.
D000818:Animals; D003287:Contrast Media / Q000008:administration & dosage*; D004231:Diuresis; D004285:Dogs; D007275:Injections, Intravenous; D007482:Iothalamate Meglumine / Q000008:administration & dosage; D007483:Iothalamic Acid / Q000008:administration & dosage*; D007668:Kidney / Q000098:blood supply; D012039:Regional Blood Flow; D014567:Urography
D003287:Contrast Media; D007483:Iothalamic Acid; D007482:Iothalamate Meglumine