The influence of long term estrogen treatment on plasma prolactin levels induced by ether anesthesia in ovariectomized rats.
2 methods of continuous estrogen delivery, polyestradiol phosphate injection and implantation of Silastic capsules of estradiol-17 beta, in ovariectomized rats induced increases in plasma prolactin in the afternoon (15.00-17.00) beginning at 1 week and continuing for 4-8 weeks. In addition these methods of estrogen treatment potentiated the ether-induced increase in plasma prolactin in the morning (9.00-11.00) beginning on week 2 and continuing for 3-8 weeks. These results indicate that estrogen activates the mechanisms that cause an afternoon surge in prolactin before potentiating a morning elevation induced by ether anesthesia.
D000758:Anesthesia; D000818:Animals; D002369:Castration; D004343:Drug Implants; D004958:Estradiol / Q000031:analogs & derivatives* / Q000494:pharmacology; D004986:Ether; D005260:Female; D011388:Prolactin / Q000097:blood*; D051381:Rats
D004343:Drug Implants; D004986:Ether; D004958:Estradiol; D011388:Prolactin