[Transplancental effect of ortho-aminoazotoluene on organ cultures of embryonal liver from mouse lines C57BL and CBA].
Transplacental influence of ortho-aminoazotoluol (OAAT) on the organ cultures of embryonal liver of highly-hepatomous mice CBA, and low-cancerous mice C57BL was the subject of this research. Transplacental influence of 12 mg OAAT caused an increase of embryonal liver organ cultures viability. Under the transplacental influence of 24 mg OAAT on CBA mice the toxic effect noted at the early cultivation period was replaced by the 20-25th cultivation days by the growth-stimulating effect. The results of in vivo experiments corresponded to the results of in vitro observations.
D000818:Animals; D001391:Azo Compounds; D005260:Female; D008113:Liver Neoplasms / Q000139:chemically induced* / Q000196:embryology; D008431:Maternal-Fetal Exchange; D051379:Mice; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D009374:Neoplasms, Experimental; D009924:Organ Culture Techniques; D011247:Pregnancy; D013045:Species Specificity; D009762:o-Aminoazotoluene
D001391:Azo Compounds; D009762:o-Aminoazotoluene
Transplatsentarnoe deĭstvie orto-aminoazotuluola na organnye kul'tury émbrional'noĭ pecheni mysheĭ linii C57BL i CBA.