Rat heart in culture as a tool to elucidate the cellular origin of lipoprotein lipase.
Lipoprotein lipase was determined in 5-day old cell cultures derived from hearts of newborn rats. With the help of the preplating method the cells were subdivided into cultures containing predominantly cardiac myocytes and into those composed mainly of mesenchymal cells. Lipoprotein lipase activity, associated with the mesenchymal cells was ten times higher than the activity found in the cultures containing mainly the myogenic cells. It is suggested that the mesenchymal cells are the progenitors of lipoprotein lipase in rat heart.
D000818:Animals; D000831:Animals, Newborn; D002478:Cells, Cultured; D008071:Lipoprotein Lipase / Q000378:metabolism*; D008854:Microscopy, Electron; D009206:Myocardium / Q000166:cytology / Q000201:enzymology* / Q000648:ultrastructure; D051381:Rats
D008071:Lipoprotein Lipase