Comparative pharmacokinetics of coumarin anticoagulants XXV: Warfarin-ibuprofen interaction in rats.
The effect of ibuprofen on the pharmacokinetics and anticoagulant action of racemic warfarin was determined in a crossover study on male Sprague-Dawley rats. At average plasma concentrations of 24-83 mg/liter, ibuprofen decreased the biological half-life and increased the total clearance of warfarin. It also increased the anticoagulant effect produced by a given plasma concentration of total (free and protein-bound) warfarin. These effects of ibuprofen appear to be a consequence of its displacing effect on warfarin in plasma.
D000818:Animals; D001777:Blood Coagulation / Q000187:drug effects; D001798:Blood Proteins / Q000378:metabolism; D006207:Half-Life; D007052:Ibuprofen / Q000494:pharmacology*; D007700:Kinetics; D008297:Male; D008657:Metabolic Clearance Rate / Q000187:drug effects; D010666:Phenylpropionates / Q000494:pharmacology*; D011485:Protein Binding / Q000187:drug effects; D051381:Rats; D013997:Time Factors; D014859:Warfarin / Q000097:blood / Q000378:metabolism*
D001798:Blood Proteins; D010666:Phenylpropionates; D014859:Warfarin; D007052:Ibuprofen