A clinical pathologic study of mercurialentis medicamentosus.
Thirty-one patients who used eye drops containing the preservative, phenylmercuric nitrate for from 3 to 15 years, developed a brownish pigmentation of the anterior capsule of the pupillary area. Light and electron microscopic studies on two lenses demonstrated deposits of dense particulate material resembling melanin pigment on and in the anterior capsule of the lens in the area of the pupil. Special studies, including electron microprobe analysis and neutron activation analysis established the presence of mercury in a lens with mercurialentis. No mercury was found in two lenses used as controls.
D000328:Adult; D000368:Aged; D001762:Blepharitis / Q000188:drug therapy; D004577:Electron Probe Microanalysis; D005260:Female; D005901:Glaucoma / Q000188:drug therapy; D006801:Humans; D007908:Lens, Crystalline / Q000032:analysis / Q000187:drug effects* / Q000648:ultrastructure; D008297:Male; D008628:Mercury / Q000032:analysis; D008875:Middle Aged; D009501:Neutron Activation Analysis; D009883:Ophthalmic Solutions; D010592:Pharmaceutic Aids; D010663:Phenylmercury Compounds / Q000009:adverse effects*; D010860:Pigments, Biological / Q000032:analysis; D010862:Pilocarpine / Q000008:administration & dosage; D011310:Preservatives, Pharmaceutical; D013432:Sulfathiazoles / Q000008:administration & dosage; D013997:Time Factors
D009883:Ophthalmic Solutions; D010592:Pharmaceutic Aids; D010663:Phenylmercury Compounds; D010860:Pigments, Biological; D011310:Preservatives, Pharmaceutical; D013432:Sulfathiazoles; D010862:Pilocarpine; D008628:Mercury