title: [Effect of heparin on nitrogen metabolism in the myocardium of dogs under normal conditions and following an experimental myocardial infarct].
abstract: Heparin administered at the initial stage of myocardium infarction is shown to prevent a number of shifts in the metabolism of protein and polynucleotides of the injured heart. It does not promote the development of some changes, but intensifies only a few of those evoked by the ligation of coronary artery in the myocardium nitrogen metabolism. The preparation inhibitory effects are also slightly pronounced in the normal myocardium where the preparation activates many metabolic reactions of nitrogen-containing biopolymers. Inactivation of enzymatic systems in a cell is likely to be not the basic, as some researchers consider, but one of the secondary mechanisms of heparin incorporation into metabolism proceeding in normal and pathologically changed tissues.
mesh_terms: D000659:AMP Deaminase / Q000378:metabolism; D000410:Alanine Transaminase / Q000378:metabolism; D000818:Animals; D001219:Aspartate Aminotransferases / Q000378:metabolism; D002403:Cathepsins / Q000378:metabolism; D004285:Dogs; D005972:Glutaminase / Q000378:metabolism; D005973:Glutamine / Q000378:metabolism; D006493:Heparin / Q000627:therapeutic use*; D009203:Myocardial Infarction / Q000188:drug therapy* / Q000201:enzymology / Q000378:metabolism; D009206:Myocardium / Q000201:enzymology / Q000378:metabolism*; D009584:Nitrogen / Q000378:metabolism*; D010447:Peptide Hydrolases / Q000378:metabolism; D011506:Proteins / Q000378:metabolism; D012313:RNA / Q000378:metabolism; D012260:Ribonucleases / Q000378:metabolism
chemical_list: D011506:Proteins; D005973:Glutamine; D012313:RNA; D006493:Heparin; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase; D012260:Ribonucleases; D002403:Cathepsins; D010447:Peptide Hydrolases; D005972:Glutaminase; D000659:AMP Deaminase; D009584:Nitrogen
vernacular_title: Vplyv heparynu na azotystyĭ obmin u sertsevomu m'iazi sobak u normi ta za eksperymental'noho infarktu miokarda