Distribution of 99mTc-1-thioglucose in rats: effect of administration route on pancreatic specificity.
Tissue distribution of 99mTc-1-thioglucose was studied in inbred albino Fisher rats. High levels of radioactivity were observed in the kidney with concurrent low pancreatic levels and pancreas/liver ratios of 0.4 following intravenous administration of the agent. High pancreatic concentration were observed with pancreas/liver ratios of 4.0 after intraperitoneal administrations. Future studies on pancreatic radiopharmaceuticals should avoid production of artificially high pancreatic values by intraperitoneal injection.
D000818:Animals; D005947:Glucose / Q000008:administration & dosage / Q000031:analogs & derivatives*; D007274:Injections, Intraperitoneal; D007275:Injections, Intravenous; D008297:Male; D010190:Pancreatic Neoplasms / Q000175:diagnosis*; D011877:Radionuclide Imaging; D051381:Rats; D011919:Rats, Inbred Strains; D013667:Technetium
D013667:Technetium; D005947:Glucose