title: Hypomagnesemic hypocalcemia. Early serum calcium and late parathyroid hormone increase with magnesium therapy.
abstract: A patient with short-bowel syndrome developed severe hypomagnesemia (0.2 mEq/liter) associated with symptomatic hypocalcemia (6.1 mg/100 ml). Parathyroid hormone (PTH) levels were normal but inappropriately low. During therapy with magnesium sulfate, an initial hypocalcemia was followed by a calcemic response without a change in PTH levels. This indicates improved bone responsiveness to circulating low levels of endogenous PTH with magnesium replenishment, which appears to be related to the restoration of magnesium-dependent cellular mechanisms. The additional observation of a slow and delayed increase in PTH, despite normal calcium levels, indicates improvement of hormone synthesis.
mesh_terms: D002118:Calcium / Q000097:blood; D005260:Female; D006801:Humans; D006996:Hypocalcemia / Q000188:drug therapy / Q000209:etiology*; D008274:Magnesium / Q000097:blood; D008275:Magnesium Deficiency; D008278:Magnesium Sulfate / Q000627:therapeutic use*; D008875:Middle Aged; D010281:Parathyroid Hormone / Q000097:blood / Q000378:metabolism*; D010710:Phosphates / Q000097:blood; D013997:Time Factors
chemical_list: D010281:Parathyroid Hormone; D010710:Phosphates; D008278:Magnesium Sulfate; D008274:Magnesium; D002118:Calcium