The metabolism of S-carboxyalkylcysteines in man.
1. The ingestion of S-(2-carboxy-1-methylethyl)-, S-(2- carboxy-1-methylpropyl)-, S-(1-carboxy-2methylpropyl)- and S-(2-carboxyethyl)-L-cysteine by man was followed by the excretion in the urine of the unchanged amino acid and the N-acetylated compounds. 2. In the rat the fraction of S-(2-carboxy-1-methylethyl)-L-[U-14C]cysteine acetylated increased as the dose level decreased. 3. The significance of these results for the excretion of S-carboxyalkyl-cysteines in man is discussed.
D000107:Acetylation; D000328:Adult; D000818:Animals; D002233:Carbocysteine / Q000031:analogs & derivatives* / Q000378:metabolism / Q000652:urine; D002854:Chromatography, Paper; D003545:Cysteine / Q000031:analogs & derivatives*; D004590:Electrophoresis, Paper; D006801:Humans; D008297:Male; D051381:Rats; D013045:Species Specificity; D013997:Time Factors
D002233:Carbocysteine; D003545:Cysteine