title: Effects of methotrexate on cellular metabolism: some critical elements in the drug-cell interaction.
mesh_terms: D000596:Amino Acids / Q000096:biosynthesis; D000818:Animals; D001692:Biological Transport; D002455:Cell Division; D002477:Cells / Q000187:drug effects / Q000378:metabolism*; D006801:Humans; D066298:In Vitro Techniques; D007700:Kinetics; D008727:Methotrexate / Q000008:administration & dosage / Q000378:metabolism / Q000494:pharmacology*; D008870:Microtubules / Q000187:drug effects; D011687:Purines / Q000096:biosynthesis; D011743:Pyrimidines / Q000096:biosynthesis; D013762:Tetrahydrofolate Dehydrogenase / Q000378:metabolism; D013763:Tetrahydrofolates / Q000096:biosynthesis / Q000378:metabolism; D013936:Thymidine / Q000378:metabolism; D013938:Thymidine Monophosphate / Q000096:biosynthesis; D013997:Time Factors
chemical_list: D000596:Amino Acids; D011687:Purines; D011743:Pyrimidines; D013763:Tetrahydrofolates; D013938:Thymidine Monophosphate; D013762:Tetrahydrofolate Dehydrogenase; D013936:Thymidine; D008727:Methotrexate