The effect of L-Dopa on the spinal monosynaptic mass reflex.
After i.v. injection of reserpine, the monosynaptic mass reflex (MSMR) is depressed in spinalized cats. However, the complete recovery of MSMR was obtained 30 min after L-Dopa application. Pimozide, a dopamine-receptor blocking agent, blocked this action of L-Dopa. It is presumed that dopaminergic receptors are involved in the action of L-Dopa on spinal MSMR.
D000818:Animals; D002415:Cats; D005260:Female; D007980:Levodopa / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D008297:Male; D010868:Pimozide / Q000494:pharmacology; D011954:Receptors, Dopamine / Q000494:pharmacology; D012023:Reflex, Monosynaptic / Q000187:drug effects*; D012110:Reserpine / Q000037:antagonists & inhibitors; D013116:Spinal Cord / Q000187:drug effects*
D011954:Receptors, Dopamine; D010868:Pimozide; D007980:Levodopa; D012110:Reserpine