Epoxide-diol pathway in the metabolism of 5H-dibenzo[b,f]-azepine (iminostilbene).
5H-Dibenzol[b,f]azepine-10,11-epoxide and 10,11-dihydro-10,11-dihydroxy-5H-dibenzo[b,f]azepine were identified by gas chromatography-mass spectrometry in rat urine as the main biotransformation products in the metabolism of 5H-dibenzo[b,f]azepine (iminostilbene). The presence of these metabolites was confirmed in vitro by incubating iminostilbene with rat liver microsomal enzymes.
D000438:Alcohols / Q000378:metabolism; D000818:Animals; D002849:Chromatography, Gas; D003984:Dibenzazepines / Q000378:metabolism*; D004852:Epoxy Compounds / Q000378:metabolism; D008401:Gas Chromatography-Mass Spectrometry; D013058:Mass Spectrometry; D008862:Microsomes, Liver; D051381:Rats
D000438:Alcohols; D003984:Dibenzazepines; D004852:Epoxy Compounds