Metal carcinogenesis: a study of the carcinogenic activity of solid metal alloys in rats.
The carcinogenic activity of seven metallic alloys was studied by implanting solid rods of each alloy in the gluteal muscles of Sprague-Dawley rats which were killed after twenty-four months. When the number of tumors in these rats was compared with the numbers in rats not operated on, in rats which had a sham operation, and in rats implanted with Silastic rods, no statistically significant differences in the incidences of the tumors in the several groups were found.
D000497:Alloys / Q000009:adverse effects*; D000818:Animals; D002081:Buttocks; D005260:Female; D005593:Fracture Fixation, Internal / Q000009:adverse effects*; D007595:Joint Prosthesis / Q000009:adverse effects*; D008297:Male; D008325:Mammary Neoplasms, Experimental / Q000139:chemically induced; D009196:Myeloproliferative Disorders / Q000139:chemically induced; D009362:Neoplasm Metastasis; D009374:Neoplasms, Experimental / Q000139:chemically induced*; D051381:Rats; D012004:Rectal Neoplasms / Q000139:chemically induced
D000497:Alloys