title: Model studies in tumor incidence.
abstract: Two models of tumor incidence predicting the latency period as a function of the applied dose of a carcinogenic compound yield the same relationship as it has been empirically stated by Bryan and Shimkin (1,2). One model is based on a single-cell damage, the other one on a disturbtion of proliferation control within the cell population. The observed latency periods compared to the predicted values show that the tommunication model is a better basis for understanding chemical carcinogenesis than the single cell incidence.
mesh_terms: D001551:Benz(a)Anthracenes; D001580:Benzopyrenes; D002273:Carcinogens; D002455:Cell Division; D004305:Dose-Response Relationship, Drug; D008954:Models, Biological; D009374:Neoplasms, Experimental / Q000139:chemically induced*; D011083:Polycyclic Compounds; D013997:Time Factors
chemical_list: D001551:Benz(a)Anthracenes; D001580:Benzopyrenes; D002273:Carcinogens; D011083:Polycyclic Compounds