Pharmacology of Bay g 2821, a long-acting, high-ceiling diuretic.
Bay g 2821 is a diuretic, from a new class of chemical substances, with both the efficacy of diuretics with a high-ceiling activity, such as furosemide, bumetanide and ethacrynic acid, and the prolonged duration of action of thiazides. Pharmacological investigations showed that Bay g 2821 was more potent than furosemide in dogs but less potent in rats. Bay g 2821 did not differ from furosemide in excretion of electrolytes. Further studies showed that Bay g 2821 had an antihypertensive effect in dogs, spontaneously hpertensive rats, and in rats with artificially-induced renal hypertension. Other pharmacological studies did not reveal any other significant effects.
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D003864:Depression, Chemical; D004232:Diuretics / Q000378:metabolism / Q000494:pharmacology*; D004285:Dogs; D004573:Electrolytes / Q000378:metabolism; D005260:Female; D005665:Furosemide / Q000494:pharmacology; D006973:Hypertension / Q000188:drug therapy; D008297:Male; D011720:Pyrazoles / Q000378:metabolism / Q000494:pharmacology*; D051381:Rats; D013997:Time Factors
D004232:Diuretics; D004573:Electrolytes; D011720:Pyrazoles; D005665:Furosemide