Anorectic activity of prostaglandin precursors.
1 Intraperitoneal and intragastric (i.g.) administration of prostaglandin precursors arachidonic (2 mg, 15 mg/kg, i.p; 30 mg/kg i.g.), linolenic (100 mg/kg i.p.; 200 mg/kg, i.g.) and linoleic (15, 100 mg/kg, i.p.; 100 mg/kg, i.g.) acids to 22 h food-deprived rats inhibits food intake. 2 This anorexia is similar to that induced by prostaglandin F2alpha (1 mg/kg, i.p.). 3 At anorectic doses these fatty acids do not cause pyrexia, in fact arachidonic acid causes hypothermia. 4 Prior treatment with indomethacin (15 mg/kg) and paracetamol (50 mg/kg) specifically reverses the anorexia and the behavioural satiety induced by the three fatty acids, while not affecting prostaglandin F2alpha-induced suppression of food intake. 5 Results of the present experiments suggest that both physiological and pharmacological modification of appetite could be brought about through an effect on prostaglandin generating systems.
D000082:Acetaminophen / Q000494:pharmacology; D000818:Animals; D001067:Appetite Depressants; D001095:Arachidonic Acids / Q000008:administration & dosage / Q000494:pharmacology; D001522:Behavior, Animal / Q000187:drug effects; D001831:Body Temperature / Q000187:drug effects; D004435:Eating / Q000187:drug effects; D005231:Fatty Acids, Unsaturated / Q000378:metabolism / Q000494:pharmacology*; D007213:Indomethacin / Q000494:pharmacology; D007441:Intubation, Gastrointestinal; D008041:Linoleic Acids / Q000008:administration & dosage / Q000494:pharmacology; D008042:Linolenic Acids / Q000008:administration & dosage / Q000494:pharmacology; D008297:Male; D011453:Prostaglandins / Q000096:biosynthesis / Q000378:metabolism*; D011460:Prostaglandins F / Q000494:pharmacology; D051381:Rats; D013997:Time Factors
D001067:Appetite Depressants; D001095:Arachidonic Acids; D005231:Fatty Acids, Unsaturated; D008041:Linoleic Acids; D008042:Linolenic Acids; D011453:Prostaglandins; D011460:Prostaglandins F; D000082:Acetaminophen; D007213:Indomethacin