Halothane in tissue of rats following repeated subanesthetic exposures.
Halothane in tissues of the rat has been measured as a function of time after five successive 3 hr exposures to 670 ppm halothane. In epididymal and perirenal fat, halothane concentrations diminished rapidly from 310 ppm to 1-2 ppm in 24 hr, with trace amounts detectable 5 days later. Brain and liver levels were reduced from 16 and 9 ppm to less than 1 ppm within 3 hr. Blood halothane was reduced from 3 ppm to less than 0.5 ppm in the same time.
D000273:Adipose Tissue / Q000378:metabolism; D000818:Animals; D001921:Brain / Q000378:metabolism; D006221:Halothane / Q000097:blood / Q000378:metabolism*; D008099:Liver / Q000378:metabolism; D008297:Male; D051381:Rats; D013997:Time Factors
D006221:Halothane