Topical steroid depression of the hypothalamic-pituitary-adrenal axis in psoriasis vulgaris.
Significant suppression of the hypothalamic-pituitary-adrenal axis has been found in patients hospitalized with psoriasis vulgaris and receiving topical fluorinated steroid therapy. Depression of thyroid function and involvement of autoimmune processes is also suggested by the data.
D015068:17-Ketosteroids / Q000652:urine; D000293:Adolescent; D000328:Adult; D000368:Aged; D005260:Female; D006801:Humans; D006854:Hydrocortisone / Q000097:blood; D006914:Hydroxysteroids / Q000652:urine; D007030:Hypothalamo-Hypophyseal System / Q000187:drug effects*; D008297:Male; D008875:Middle Aged; D010907:Pituitary Hormones / Q000097:blood; D011565:Psoriasis / Q000188:drug therapy*; D013259:Steroids, Fluorinated / Q000494:pharmacology* / Q000627:therapeutic use; D013963:Thyroid Hormones / Q000097:blood
D015068:17-Ketosteroids; D006914:Hydroxysteroids; D010907:Pituitary Hormones; D013259:Steroids, Fluorinated; D013963:Thyroid Hormones; D006854:Hydrocortisone