Effect of phenobarbital on the disposition of intravenous theophylline.
The disposition of intravenous doses of theophylline was determined in normal male subjects before and after treatment with phenobarbital 2 wk. Although there was some variation in disposition of the 2 drugs, there were no significant effects of phenobarbital on theophylline kinetics. We conclude that theophylline dosage need not be altered during concomitant administration of phenobarbital.
D000328:Adult; D001682:Biological Availability; D006801:Humans; D007263:Infusions, Parenteral; D008297:Male; D010634:Phenobarbital / Q000494:pharmacology*; D010919:Placebos; D012907:Smoking; D013806:Theophylline / Q000008:administration & dosage / Q000378:metabolism*
D010919:Placebos; D013806:Theophylline; D010634:Phenobarbital