title: Urea as a selective inhibitor of argininosuccinate lyase.
abstract: The effect of urea on various ornithine cycle enzymes has been investigated. It was demonstrated that argininosuccinate lyase was the only ornithine cycle enzyme inhibited by urea in a competitive manner. Based on the data presented the possible role of urea in maintaining a physiological range of intracellular and extracellular urea concentration by controlling hepatic ureogenesis was discussed.
mesh_terms: D000818:Animals; D001119:Arginase / Q000378:metabolism; D001120:Arginine / Q000096:biosynthesis; D001123:Argininosuccinate Lyase / Q000037:antagonists & inhibitors*; D001124:Argininosuccinate Synthase / Q000378:metabolism; D002956:Citrulline / Q000096:biosynthesis; D007700:Kinetics; D008190:Lyases / Q000037:antagonists & inhibitors*; D008930:Mitochondria, Liver / Q000201:enzymology / Q000378:metabolism; D051381:Rats; D014508:Urea / Q000494:pharmacology*
chemical_list: D002956:Citrulline; D014508:Urea; D001120:Arginine; D001119:Arginase; D008190:Lyases; D001123:Argininosuccinate Lyase; D001124:Argininosuccinate Synthase