Heterotransplantation of human fetal pituitaries in nude mice.
The heterotransplantation of minced human fetal pituitaries into adult thymus-aplastic nude mice is described. Development and growth of such grafts were observed in 16 of 21 recipient mice. Histological examinations of the transplants showed typical adenohypophyseal cells. Neurohypophyseal cells could never be detected. The levels of human growth hormone (hGH) varied between 0.8 and 42.0 ng/ml in the plasma of the hosts (mean value 7.2 ng/ml, by radioimmunoassay).
D000818:Animals; D006085:Graft Survival; D013006:Growth Hormone / Q000097:blood; D006801:Humans; D008321:Mammary Glands, Animal / Q000601:surgery; D051379:Mice; D008819:Mice, Nude; D008938:Mitosis; D010902:Pituitary Gland / Q000196:embryology / Q000637:transplantation*; D010903:Pituitary Gland, Anterior / Q000166:cytology / Q000637:transplantation; D014183:Transplantation, Heterologous
D013006:Growth Hormone