title: The use of beclomethasone diproprionate inhaler complicated by the development of an eosinophilic pneumonia reaction.
abstract: As an insoluble steroid aerosol, beclomethasone diproprionate was recently made available in the United States. Only minor complications have been reported previously. A more serious development of adrenal insufficiency may occur upon the improper replacement of systemic steroids. We report on a patient who developed the clinical findings of pulmonary eosinophilia. The possible mechanisms for this complication in out patient are discussed. While a lower systemic steroid dosage may have been the provoking factor, we feel that an adverse reaction to oleic acid, a dispersing agent in the aerosol freon vehicle, is a strong possibility.
mesh_terms: D000335:Aerosol Propellants / Q000009:adverse effects; D000336:Aerosols; D000368:Aged; D001249:Asthma / Q000150:complications* / Q000188:drug therapy; D001507:Beclomethasone / Q000008:administration & dosage / Q000009:adverse effects*; D005260:Female; D006801:Humans; D009829:Oleic Acids / Q000009:adverse effects; D011657:Pulmonary Eosinophilia / Q000209:etiology*
chemical_list: D000335:Aerosol Propellants; D000336:Aerosols; D009829:Oleic Acids; D001507:Beclomethasone