[Pulmonary capillary ultrastructure during accumulation of a phosphoorganic cholinesterase inhibitor in the lungs].
The ultrastructure of the blood-air barrier in rabbits was investigated during different periods after i. v. injection of high hydrophobic organophosphorus cholinesterase inhibitor GA-95. According to the biochemical data, this inhibitor is accumulated mostly in the lungs. The most pronounced changes observed 20 min after injection involved a significant increase in number of pinocytose vesicles in the cytoplasm of endothelial cells of lung capillaries. The morphological data may serve an indirect evidence for the inhibitor sorption at the surface of lung capillaries.
D000818:Animals; D002196:Capillaries / Q000187:drug effects* / Q000648:ultrastructure; D002800:Cholinesterase Inhibitors / Q000494:pharmacology*; D004727:Endothelium; D008854:Microscopy, Electron; D009946:Organothiophosphorus Compounds / Q000494:pharmacology*; D011650:Pulmonary Alveoli / Q000098:blood supply*; D011817:Rabbits
D002800:Cholinesterase Inhibitors; D009946:Organothiophosphorus Compounds; C014888:O-hexyl-S-hexylmethyl thiophosphonate
Ul'trastruktura legochnykh kapilliarov pri nakoplenii v legkikh fosfororganicheskogo ingibitora kholinésteraza.