Aortic endothelial cell replication. I. Effects of age and hypertension in the rat.
The daily rate of cell replication in the aortic endothelium of the normal rat falls from a maximum of 13% at birth to 0.1-0.3% at age 5-6 months. This residual rate of replication largely represents the turnover rate of the endothelium in normal animals. After renal hypertension of 2-3 weeks duration, however, the rate of replication rises 10-fold to an average value of 1.6%. This increase may represent an increase in turnover; however, it probably represent, at least in part, a proliferative response to cover the expanded luminal surface of the dilated vessel.
D000367:Age Factors; D000818:Animals; D001011:Aorta / Q000473:pathology; D001158:Arteries / Q000473:pathology*; D001795:Blood Pressure Determination; D002455:Cell Division; D004727:Endothelium / Q000473:pathology; D005260:Female; D006973:Hypertension / Q000473:pathology*; D008722:Methods; D051381:Rats; D014316:Tritium
D014316:Tritium