Antagonism of smooth muscle responses to oxytocin and vasopressin by salsolinol.
The responses of isolated smooth muscle tissues to the polypeptides oxytocin, vasopressin and bradykinin were evaluated in the presence of the tetrahydroisoquinoline salsolinol. Significant antagonism occurred to oxytocin and vasopressin while the effects of bradykinin were unaltered. These results suggest that the in vivo formation of salsolinol after ethanol consumption could have significant physiological consequences.
D000470:Alkaloids / Q000494:pharmacology*; D000818:Animals; D005260:Female; D006168:Guinea Pigs; D007082:Ileum / Q000187:drug effects; D066298:In Vitro Techniques; D007546:Isoquinolines / Q000494:pharmacology*; D008297:Male; D051379:Mice; D009119:Muscle Contraction / Q000187:drug effects*; D009130:Muscle, Smooth / Q000187:drug effects*; D010121:Oxytocin / Q000037:antagonists & inhibitors*; D051381:Rats; D012444:Saccule and Utricle / Q000187:drug effects; D014590:Uterine Contraction / Q000187:drug effects; D014667:Vasopressins / Q000037:antagonists & inhibitors*
D000470:Alkaloids; D007546:Isoquinolines; D014667:Vasopressins; D010121:Oxytocin