Metabolic studies with the nonnutritive sweetener cycloheptylsulfamate.
The nonnutritive sweetener cycloheptylsulfamate was administered orally to rabbits and rats. The urine of each species was separately collected for 3 days and examined for the metabolites cycloheptylamine, cycloheptanone, and cycloheptanol and for cycloheptylsulfamate. A previously tested GLC method was adapted for the determination of the metabolites. Cycloheptylsulfamate was assayed by hydrolysis and subsequent measurement of the absorbance of the product formed (lambdamax=489 nm) by the liberated amine with p-benzoquinone. The conversions to the metabolites were 0.276, 0.390, and 0.170%, respectively, in rabbits and 0.064, 0.022, and 0.017%, respectively, in rats.
D000818:Animals; D001711:Biotransformation; D002849:Chromatography, Gas; D003494:Cyclamates; D003508:Cycloheptanes / Q000652:urine*; D005260:Female; D008027:Light; D011817:Rabbits; D051381:Rats; D013053:Spectrophotometry; D013451:Sulfonic Acids / Q000652:urine; D013549:Sweetening Agents / Q000652:urine*
D003494:Cyclamates; D003508:Cycloheptanes; D013451:Sulfonic Acids; D013549:Sweetening Agents; C014434:cycloheptylsulfamate