[Effect of dextropoxyphene on oxidative phosphorylation in brain and liver of rat (author's transl)].
Dextropropoxyphene hydrochloride increases significantly oxygen uptake in whole rat brain homogenates at concentrations of 10(-4), 10(-5), 10(-6) M when using sucrose 0.25 M pH 7.4 as incubation medium. If substrate and cofactors are added to the sucrose, this drug decreases oxygen uptake at 10(-3) M concentration in brain and liver rat homogenates, and it also decreases significantly the P:O quotient of mitochondria in both organs by uncoupling the oxidative phosphorylation.
D000818:Animals; D001921:Brain / Q000166:cytology / Q000378:metabolism*; D011431:Dextropropoxyphene / Q000494:pharmacology*; D008099:Liver / Q000378:metabolism*; D008297:Male; D008928:Mitochondria / Q000378:metabolism; D008930:Mitochondria, Liver / Q000378:metabolism; D010085:Oxidative Phosphorylation / Q000187:drug effects*; D010101:Oxygen Consumption / Q000187:drug effects*; D010758:Phosphorus / Q000378:metabolism; D051381:Rats
D010758:Phosphorus; D011431:Dextropropoxyphene
Efecto del dextropropoxifeno sobre el consumo de oxígeno y fosforilización oxidativa de cerebro e higado de rata in vitro.