Effect of beta-aminopropionitrile on bone mechanical properties.
In vivo beta-aminopropionitrile treatment caused significant changes in the mechanical properties of rat femora. In femora treated with beta-aminopropinitrile as compared with controls, there was a 44 per cent decrease in bone stiffness and a 47 per cent increase in bone deformation to failure. Bone ash was decreased 5 per cent in the treated group. It is likely that the decrease in bone ash was secondary to impaired intermolecular bone-collagen cross-linking, which is a well established consequence of treatment with beta-aminopropionitrile. Thus, beta-aminopropionitrile influences bone mechanical properties directly by impairing collagen cross-linking and indirectly by altering bone-matrix mineralization.
D000629:Aminopropionitrile / Q000494:pharmacology*; D000818:Animals; D001696:Biomechanical Phenomena; D001857:Bone Matrix / Q000187:drug effects; D002118:Calcium / Q000097:blood; D005269:Femur / Q000187:drug effects*; D008297:Male; D010758:Phosphorus / Q000097:blood; D051381:Rats
D000629:Aminopropionitrile; D010758:Phosphorus; D002118:Calcium