The prevention of alloxan-induced diabetes in mice by dimethyl sulfoxide.
Dimethyl sulfoxide (DMSO, 7.3 g/kg) administered to mice prior to alloxan completely protected against the diabetogenic actions of 50 mg/kg alloxan. The same dose of DMSO provided a partial protection against 75 mg/kg alloxan. This protection against alloxan-induced diabetes is consistent with the scavenging of the hydroxyl radical by DMSO.
D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D003921:Diabetes Mellitus, Experimental / Q000097:blood / Q000517:prevention & control*; D004121:Dimethyl Sulfoxide / Q000494:pharmacology / Q000627:therapeutic use*; D008297:Male; D051379:Mice
D001786:Blood Glucose; D004121:Dimethyl Sulfoxide