title: Role of bacterial overgrowth in the malabsorption syndrome of primary small intestinal lymphoma in Iran.
abstract: Malabsorption studies were performed on five Iranian patients with primary small intestinal lymphoma. The effect of oral tetracycline (1.0 g daily) was also studied in three of the above subjects. The results of breath tests (utilizing glycine-1-14C-cholic acid) were abnormal in all five subjects before the antibiotic treatment. Oral tetracycline had a striking effect towards normalizing the results of breath tests. Schilling tests (with intrinsic factor) improve in two patients and steatorrhea improved in all and there was significant weight gain. The antibiotic had no apparent effect on D-xylose or folate absorption tests. It is concluded that bacterial overgrowth in the small intestinal lumen is an important contributory factor to the malabsorption syndrome of this disease.
mesh_terms: D000328:Adult; D001424:Bacterial Infections / Q000150:complications* / Q000188:drug therapy; D005260:Female; D006801:Humans; D007414:Intestinal Neoplasms / Q000150:complications*; D007421:Intestine, Small; D007492:Iran; D008223:Lymphoma / Q000150:complications*; D008286:Malabsorption Syndromes / Q000209:etiology*; D008297:Male; D013752:Tetracycline / Q000627:therapeutic use
chemical_list: D013752:Tetracycline