title: The role of the subependymal plate in the origin of gliomas induced by ethylnitrosourea in the rat brain.
abstract: The fine structure of early cell proliferations induced transplacentally by ethylnitrosourea in the rat brain reveals that the cells show features of the undifferentiated cells of the subependymal plate: high nuclear-cytoplasmic ratio, scarity of cell organelles and dominance of free over membrane-bound ribosomes. These findings suggest that most, if not all, gliomas induced by ethylnitrosourea originate from these primitive cells.
mesh_terms: D000818:Animals; D001921:Brain / Q000473:pathology; D001932:Brain Neoplasms / Q000139:chemically induced* / Q000473:pathology; D003337:Corpus Callosum / Q000648:ultrastructure; D005038:Ethylnitrosourea; D005260:Female; D005910:Glioma / Q000139:chemically induced* / Q000473:pathology; D008854:Microscopy, Electron; D009374:Neoplasms, Experimental / Q000139:chemically induced / Q000473:pathology; D009474:Neurons / Q000648:ultrastructure; D009607:Nitrosourea Compounds; D011247:Pregnancy; D051381:Rats
chemical_list: D009607:Nitrosourea Compounds; D005038:Ethylnitrosourea