[Complex laboratory-morphologic study of allergic joint inflammation in rabbits].
During the period of sensitization and in the dynamics of the development of the articular allergic inflammation in rabbits there occured regular slowing down of the properdin activity, decrease in the compliment titres and increase in the blood plasma magnesium content. An increased liability of the basophilic leukocytes to damage and an elevated activity of acid phosphotase in lymphocytes of the peripheral blood were also noted. In the acute period of inflammation the synovial sheaths were found to be diffusibly infiltrated by the lymphoid-histocytic and plasma cells. Proliferation of synoviocytes and the appearance therein of the PAS-positive granules were observed. Weakening of the myocardial staining with Schiff's reagent was established. The processes of disorganization of the connective tissue in a joint and in the heart were closely conjugated and manifested themselves in mucoid and fibrinoid swelling, and changes in the PAS-reaction. Dissociation of the natural resistance of the organism was revealed: mobilization of the processes of immunogenesis and inhibition of the nonspecific link of protection. Decrease in the immunological reactivity was associated with formation of hypersensitivity of delayed type. Cosequently, arthritis developed in rabbits on the immune basis.
D000818:Animals; D001172:Arthritis, Rheumatoid / Q000276:immunology / Q000378:metabolism / Q000473:pathology*; D001491:Basophils / Q000648:ultrastructure; D003165:Complement System Proteins; D003594:Cytoplasmic Granules / Q000648:ultrastructure; D004195:Disease Models, Animal; D006644:Histiocytes; D006651:Histocytochemistry; D007596:Joints / Q000378:metabolism / Q000473:pathology*; D008214:Lymphocytes; D008274:Magnesium / Q000097:blood; D009206:Myocardium / Q000473:pathology*; D011134:Polysaccharides / Q000378:metabolism; D011414:Properdin / Q000097:blood; D011817:Rabbits; D013583:Synovial Membrane / Q000378:metabolism
D011134:Polysaccharides; D011414:Properdin; D003165:Complement System Proteins; D008274:Magnesium
Kompleksnoe laboratorno-morfologicheskoe issledovanie allergicheskogo vospaleniia v sustave u krolikov.