Exerimental head injury in the rat. Part 2: Regional brain energy metabolism in concussive trauma.
A standardized model of acceleration concussion in the rat was used for the study of cerebral energy metabolism during the acute concussive reaction. Impact velocities of 7 and 9 m/sec were used, and the cerebral metabolic state was determined 1, 4, and 15 minutes after the impact. A concussive response could be sustained with a normal energy state in the tissue, but with the more intense reaction to a 9 m/sec impact, energy depletion usually occurred. At 1 minute these changes were most pronounced in the brain-stem regions. At 4 minutes the reactions were more varied but a progression usually occurred during this time, while at 15 minutes restitution was indicated. Hypoxia due to neurogenic pulmonary edema aggravated the state. The findings are compatible with a high metabolic rate during concussion, but progressive changes indicate the rapid appearance of complicating factors, including hypoxemia and probably also ischemia.
D000227:Adenine Nucleotides / Q000378:metabolism; D000818:Animals; D001794:Blood Pressure; D001831:Body Temperature; D001921:Brain / Q000378:metabolism*; D001924:Brain Concussion / Q000150:complications / Q000378:metabolism*; D004734:Energy Metabolism; D000860:Hypoxia / Q000150:complications; D007773:Lactates / Q000378:metabolism; D008297:Male; D010725:Phosphocreatine / Q000378:metabolism; D011773:Pyruvates / Q000378:metabolism; D051381:Rats
D000227:Adenine Nucleotides; D007773:Lactates; D011773:Pyruvates; D010725:Phosphocreatine