title: Current concepts in management of lupus nephritis.
abstract: Since prognosis seems to vary according to which of several possible types of disease is present, the first step is renal biopsy and histologic classification. Management options thereafter-both conventional (steroid therapy) and investigational (cytotoxic agents plus steroids, thymic hormone replacement, steroid "pulse" therapy)-are discussed in terms of recent clincal results and theoretical mechanisms of action.
mesh_terms: D000818:Animals; D001379:Azathioprine / Q000627:therapeutic use; D003520:Cyclophosphamide / Q000627:therapeutic use; D006801:Humans; D007678:Kidney Glomerulus / Q000473:pathology; D008180:Lupus Erythematosus, Systemic / Q000150:complications* / Q000175:diagnosis / Q000209:etiology; D008775:Methylprednisolone / Q000008:administration & dosage / Q000627:therapeutic use; D051379:Mice; D009393:Nephritis / Q000150:complications* / Q000175:diagnosis / Q000209:etiology; D011241:Prednisone / Q000627:therapeutic use; D013947:Thymosin / Q000627:therapeutic use
chemical_list: D013947:Thymosin; D003520:Cyclophosphamide; D001379:Azathioprine; D011241:Prednisone; D008775:Methylprednisolone