title: [Hematopoiesis in dogs irradiated with protons in lethal doses with screening of the bone marrow].
abstract: The paper presents the results of a 6-year investigation of hemopoiesis of dogs which were exposed to double irradiations (with a 1.5-month interval) with protons at a dose of 350 rad when different parts of the body (head, chest, abdomen, pelvis) were shielded. Throughout the entire period the dogs showed moderate leucopenia and by the end of the investigation insignificant anemia. The dogs irradiated with shielded abdomen displayed disturbances in bone marrow hemopoiesis, whereas other dogs exhibited relative, although transient, normalization. All the dogs showed a significant decrease of erythropoiesis and a relative stability of leucopoiesis as well as a significant elevation of the number of reticulocytes, monocytes and plasmocytes 5.5 year after irradiation.
mesh_terms: D000208:Acute Disease; D000818:Animals; D001772:Blood Cell Count; D001853:Bone Marrow / Q000528:radiation effects*; D004285:Dogs; D004307:Dose-Response Relationship, Radiation; D006410:Hematopoiesis / Q000528:radiation effects*; D011522:Protons; D011829:Radiation Dosage; D011833:Radiation Injuries, Experimental / Q000503:physiopathology; D011835:Radiation Protection; D013997:Time Factors
chemical_list: D011522:Protons
vernacular_title: Krovetvorenie sobak, obluchennykh protonami v smertel'nykh dozakh pri ékranirovanii kostnogo mozga.