Inabilities as an immunoadjuvant of cell walls of the group B peptidoglycan types and those of arthrobacters.
The cell walls from several bacterial species whose peptidoglycans are the group B types (Schleifer and Kandler) and those of two arthrobacters were shown to be inactive or only weakly active as an immunoadjuvant in both induction of delayed-type hypersensitivity and stimulation of circulating antibody levels to ovalbumin when administered to guinea pigs as a water-in-oil emulsion, in sharp contrast to the adjuvant-active cell walls of the group A peptidoglycan types which were previously studied. The possible reason for the inabilities as an adjuvant of these cell walls was discussed in relation to the chemical structures of peptidoglycans.
D000276:Adjuvants, Immunologic; D000818:Animals; D000917:Antibody Formation; D001173:Arthrobacter / Q000276:immunology*; D001419:Bacteria / Q000276:immunology*; D002473:Cell Wall / Q000276:immunology; D055598:Chemical Phenomena; D002621:Chemistry; D006168:Guinea Pigs; D006968:Hypersensitivity, Delayed / Q000276:immunology*; D010047:Ovalbumin / Q000276:immunology; D010457:Peptidoglycan / Q000145:classification / Q000276:immunology*; D013045:Species Specificity
D000276:Adjuvants, Immunologic; D010457:Peptidoglycan; D010047:Ovalbumin