[Lidoflazine derivatives with cycloaliphatic residues of coronary dilator activity].
The preparation of some derivatives of lidoflazine bearing a phenylcyclohexane residue in place of the m.xylene is described. Study of the coronary dilating activity on the isolated heart showed that this activity is markedly increased by the modification. Acute toxicity in rats is also strongly increased.
D000818:Animals; D055598:Chemical Phenomena; D002621:Chemistry; D003331:Coronary Vessels / Q000187:drug effects; D008013:Lidoflazine / Q000031:analogs & derivatives / Q000138:chemical synthesis* / Q000494:pharmacology / Q000633:toxicity; D051379:Mice; D010879:Piperazines / Q000138:chemical synthesis*; D014665:Vasodilator Agents / Q000138:chemical synthesis* / Q000633:toxicity
D010879:Piperazines; D014665:Vasodilator Agents; D008013:Lidoflazine
Derivati della lidoflazina con residui cicloalifatici ad attività coronarodilatatrice.