title: Gastric acid secretion in gastric fistula dogs after antral denervation and antrectomy.
abstract: Acid secretion in Pavlov pouches in dogs is known to increase after antrectomy in response to histamine and gastrin. Dogs with gastric fistulae were tested with histamine and tetragastrin as a control study. The vagal nerve fibers to the antrum were divided and the dogs underwent repeat testing. Finally an antrectomy was performed and final dose-response data  were collected. After antrectomy there was an increased acid response to histamine and tetragastrin. We postulate that the vagal fibers innervating the antrum are probably not a factor in this increase. Furthermore, we believe that the increased acid secretion after antrectomy observed in the dog and the decrease known to occur in the human being is a species difference and is not related to the pouch method of study used in earlier studies of the antrectomized dog.
mesh_terms: D000818:Animals; D003714:Denervation; D004285:Dogs; D004305:Dose-Response Relationship, Drug; D004386:Duodenum / Q000294:innervation; D005747:Gastric Fistula / Q000378:metabolism*; D005750:Gastric Juice / Q000378:metabolism*; D005755:Gastrins / Q000031:analogs & derivatives / Q000494:pharmacology; D006632:Histamine / Q000494:pharmacology; D006801:Humans; D011706:Pyloric Antrum / Q000294:innervation* / Q000601:surgery; D013045:Species Specificity; D013268:Stimulation, Chemical; D014628:Vagotomy; D014630:Vagus Nerve / Q000502:physiology
chemical_list: D005755:Gastrins; D006632:Histamine