Inotropic effects of 1-alpha-acetylmethadol (LAAM).
Inotropic effects of 1-alpha-acetylmethadol, 1-alpha-acetylnormethadol and 1-alpha-acetyldinormethadol were studied uilizing isolated left atria of guinea pigs. All three agents produced a biphasic response. Lower concentrations produced a slight, but significant increase in contractile force (p less than 0.05) and higher concentrations decreased contractile force (p less than 0.05). Significant drug interactions also were observe. The parent compound, 1-alpha-acetylmethadol, decrease the maximum positive inotropic response obtained with ouabain as well as that obtained with norepinephrine.
D000818:Animals; D004347:Drug Interactions; D006168:Guinea Pigs; D066298:In Vitro Techniques; D008691:Methadone / Q000031:analogs & derivatives*; D008692:Methadyl Acetate / Q000494:pharmacology*; D009200:Myocardial Contraction / Q000187:drug effects*; D009638:Norepinephrine / Q000037:antagonists & inhibitors; D010042:Ouabain / Q000037:antagonists & inhibitors
D010042:Ouabain; D008692:Methadyl Acetate; D008691:Methadone; D009638:Norepinephrine