Acrokeratosis verruciformis: (Hopf)--A clinical entity?
Contrary to the unitarian concept of acrokeratosis verruciformis and Darier's disease, a comparative familial, clinical and histopathological analysis of six cases each of these two diseases has suggested that they are separate entities. Though clinically similar, acrokeratosis remained non-dyskeratotic throughout life, whereas the acral lesions of Darier's disease showed, on careful scrutiny and follow-up, various gradations of benign acantholytic dyskeratosis. Malignant transformation indicated that dyskeratosis in Hopf's disease would be very rare and of a different nature. The probability of a genetic linkage between the two genodermatoses is reviewed and discussed.
D000169:Acrodermatitis / Q000235:genetics / Q000473:pathology / Q000503:physiopathology; D000293:Adolescent; D000328:Adult; D007644:Darier Disease / Q000235:genetics / Q000473:pathology / Q000503:physiopathology; D005260:Female; D006801:Humans; D007642:Keratosis / Q000235:genetics / Q000473:pathology / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D009506:Nevus / Q000235:genetics / Q000473:pathology / Q000503:physiopathology