[Effect of insulin on RNA biosynthesis in the chromatin fractions of the liver of rats of different age].
Experiments were conducted on rats; a study was made of the age changes of insulin action on the genetic apparatus of hepatocytes. Adult (6-8-month-old) rats showed the greatest elevation of transcribing capacity of the repressed chromatin fraction 2 hours after the hormone administration, no changes occurred in the active chromatin fraction. The maximum increase of the labeled precursor inclusion in old (24--26-month-old) rats was seen 3 hours after insulin injection both in repressed and active chromatin.
D000375:Aging; D000818:Animals; D002843:Chromatin / Q000378:metabolism*; D007328:Insulin / Q000494:pharmacology*; D008099:Liver / Q000166:cytology*; D012313:RNA / Q000096:biosynthesis*; D051381:Rats; D014158:Transcription, Genetic / Q000187:drug effects
D002843:Chromatin; D007328:Insulin; D012313:RNA
Vliianie insulina na biosintez RNK vo fraktsiiakh khromatina pecheni krys razlichnogo vozrasta.