[The effect of ethanol-applications on uric acid-metabolism in minipigs (author's transl)].
The effect of several drugs on minipigs was examined over a period of upto 3 months. The drugs applied were: ethanol, etacryn acid (per os), ethanol, maleic acid, physiological NaCl--solution (by infusion). The creatinin-, uric acid-, lactat- and haematocrit-values of the serum and blood as well as the creatinin- and uric-excretion were followed. For ethanol and maleine acid an increase of the creatinin- and uric acid-excretion was found. This was accompanied by an increase of the haematocrit value. If the diuresis was augmented by certain substances, a more or less pronounced uricosuria was found. The measured values will be discussed, especially how the renal function may be involved.
D000818:Animals; D003404:Creatinine / Q000097:blood; D004976:Ethacrynic Acid / Q000494:pharmacology; D000431:Ethanol / Q000494:pharmacology*; D006400:Hematocrit; D007773:Lactates / Q000097:blood; D008297:Male; D008298:Maleates / Q000494:pharmacology; D012965:Sodium Chloride / Q000494:pharmacology; D013552:Swine / Q000378:metabolism*; D014527:Uric Acid / Q000097:blood / Q000378:metabolism*
D007773:Lactates; D008298:Maleates; D014527:Uric Acid; D000431:Ethanol; D012965:Sodium Chloride; D003404:Creatinine; D004976:Ethacrynic Acid
Untersuchungen über den Einfluss von Aethanol-Gaben auf den Harnsäurestoffwechsel von Minipigs