Effects of 3,4-dimethoxyphenethylamine derivatives on monoamine oxidase.
The cactus alkaloid 3,4-dimethoxyphenethylamine and its naturally occurring N-methylated homologs inhibited the deamination of tyramine and tryptamine by rat brain monoamine oxidase. In contrast, the beta-hydroxylated derivatives of this series failed to inhibit the action of monoamine oxidase on both tyramine and tryptamine.
D000818:Animals; D001921:Brain / Q000648:ultrastructure; D003864:Depression, Chemical; D004118:Dimethoxyphenylethylamine / Q000031:analogs & derivatives / Q000138:chemical synthesis / Q000494:pharmacology*; D005260:Female; D066298:In Vitro Techniques; D008928:Mitochondria / Q000378:metabolism; D008995:Monoamine Oxidase / Q000378:metabolism*; D008996:Monoamine Oxidase Inhibitors; D010084:Oxidation-Reduction; D010627:Phenethylamines / Q000494:pharmacology*; D051381:Rats; D014363:Tryptamines / Q000378:metabolism; D014439:Tyramine / Q000378:metabolism
D004118:Dimethoxyphenylethylamine; D008996:Monoamine Oxidase Inhibitors; D010627:Phenethylamines; D014363:Tryptamines; D008995:Monoamine Oxidase; D014439:Tyramine