Test for carcinogenicity of organic contaminants of United States drinking waters by pulmonary tumor response in strain A mice.
The production of lung adenomas in strain A following multiple i.p. injections of selected organic water contaminants was investigated. Of the 16 contaminants tested, only bromoform produced a pulmonary adenoma response that was significantly greater than the pulmonary adenoma response of vehicle-treated control mice.
D000236:Adenoma / Q000139:chemically induced*; D000818:Animals; D002274:Carcinogens, Environmental; D004353:Drug Evaluation, Preclinical; D006842:Hydrocarbons, Brominated / Q000506:poisoning; D008175:Lung Neoplasms / Q000139:chemically induced*; D008297:Male; D008752:Methylene Chloride / Q000506:poisoning; D051379:Mice; D008805:Mice, Inbred A; D009374:Neoplasms, Experimental / Q000139:chemically induced; D014481:United States; D014873:Water Pollutants / Q000633:toxicity*; D014874:Water Pollutants, Chemical / Q000633:toxicity*
D002274:Carcinogens, Environmental; D006842:Hydrocarbons, Brominated; D014873:Water Pollutants; D014874:Water Pollutants, Chemical; D008752:Methylene Chloride