title: Heterogeneity of proteoglycans in developing chick limb cartilage.
abstract: Proteoglycan heterogeneity was studied during the maturation of embryonic-chick limb cartilage in vivo. The results suggest that during the differentiation of limb-bud cartilage the aggregated forms of proteoglycans increase between stages 24 and 35, whereas the non-aggregated or monomeric forms decrease. Only one link protein is found in stage-24 limb buds, whereas two are present at stage 35. Evidence suggests that the synthesis of link proteins may be a regulatory factor in limb chondrogenesis.
mesh_terms: D000818:Animals; D002356:Cartilage / Q000196:embryology* / Q000378:metabolism; D002642:Chick Embryo; D002850:Chromatography, Gel; D004591:Electrophoresis, Polyacrylamide Gel; D005121:Extremities / Q000196:embryology* / Q000378:metabolism; D008970:Molecular Weight; D011506:Proteins / Q000032:analysis; D011509:Proteoglycans / Q000096:biosynthesis / Q000378:metabolism*; D012967:Sodium Dodecyl Sulfate; D013431:Sulfates / Q000378:metabolism; D014574:Uronic Acids / Q000378:metabolism
chemical_list: D011506:Proteins; D011509:Proteoglycans; D013431:Sulfates; D014574:Uronic Acids; D012967:Sodium Dodecyl Sulfate