Quantitative analysis of the distribution of 99mTc-labelled ethylene hydroxy diphosphonate in young rats.
The distribution of 99mTc-labelled ethylene 1-hydroxy-1,1-diphosphonate (EHDP) in young rats was studied 1, 3, 6 and 9 h after intraperitoneal injection. The concentration of 99mTc in bone was 8-10 times higher than that in the kidneys and 20-1000 times higher than those in other soft tissues. The concentration in bone remained constant throughout the observation time. In some of the animals sacrificed after 3, 6, or 9 h the uptake in the liver and spleen was higher than that found in the majority of the animals.
D000818:Animals; D001842:Bone and Bones / Q000378:metabolism; D004164:Diphosphonates / Q000378:metabolism*; D007668:Kidney / Q000378:metabolism; D008099:Liver / Q000378:metabolism; D011877:Radionuclide Imaging / Q000379:methods; D051381:Rats; D013154:Spleen / Q000378:metabolism; D013667:Technetium / Q000378:metabolism*
D004164:Diphosphonates; D013667:Technetium