Species variation with respect to the metabolism and excretion of d-amphetamine and d,l-N-hydroxyamphetamine succinate.
The metabolism of amphetamine and N-hydroxyamphetamine was studied in the rat and mouse. Extensive reduction of N-hydroxyamphetamine to amphetamine occurred in both species. In addition, para-hydroxylation of amphetamine was a common metabolic route, although it was more predominant in the rat. No appreciable difference in the 24-h excretion of amphetamine and p-hydroxyamphetamine in either species was seen after substitution of N-hydroxyamphetamine for amphetamine.
D000662:Amphetamines / Q000138:chemical synthesis / Q000378:metabolism* / Q000652:urine; D000818:Animals; D001921:Brain / Q000378:metabolism; D003913:Dextroamphetamine / Q000378:metabolism*; D008297:Male; D051379:Mice; D009206:Myocardium / Q000378:metabolism; D051381:Rats; D013045:Species Specificity; D010136:p-Hydroxyamphetamine / Q000138:chemical synthesis / Q000378:metabolism / Q000652:urine
D000662:Amphetamines; D010136:p-Hydroxyamphetamine; D003913:Dextroamphetamine