[Neurophysiological study in the cat of 2 substituted benzamides : sulpiride and sultopride].
Using three distinct electrophysiological tests in unanesthetized cat preparations (hippocampal theta, " caudat spindles " and stereotyped hind limb locomotor rhythms) two psychotropic benzamide derivatives (Sulpirid and Sultoprid) were tested both through systemic administration and local intracerebral microinjections. Our conclusions are that : a) Sulpirid activates the limbic system and locomotor rhythms, while deafferenting the higher " telodiencephalic " structures ; b) Sultoprid is, in revanche, at the same time deafferenting higher structure and depressing the lower one; c ) the hypothalamus represents one of the preferential targets for action of these substances.
D000818:Animals; D001921:Brain / Q000187:drug effects*; D002415:Cats; D008032:Limbic System / Q000187:drug effects; D009043:Motor Activity / Q000187:drug effects; D013469:Sulpiride / Q000031:analogs & derivatives* / Q000494:pharmacology*; D013826:Theta Rhythm
D013469:Sulpiride
Etude neurophysiologique chez le chat de deux benzamides substituées : le sulpiride et le sultopride.