Encephalopathy induced by oral hypoglycemic drugs.
Three patients experienced severe hypoglycemic encephalopathy during oral therapy of adult-onset diabetes mellitus. Disabling residual neurological deficits were observed in two of these patients. The insidious time course of drug-induced hypoglycemia appeared to prevent patient recognition of sustained hypoglycemia. These cases indicate the need for further caution in the administration of oral hypoglycemic agents.
D001928:Brain Diseases, Metabolic / Q000139:chemically induced* / Q000175:diagnosis; D002747:Chlorpropamide / Q000009:adverse effects; D003920:Diabetes Mellitus / Q000628:therapy; D005260:Female; D006801:Humans; D007003:Hypoglycemia / Q000139:chemically induced*; D007004:Hypoglycemic Agents / Q000009:adverse effects*; D008297:Male; D008875:Middle Aged; D009460:Neurologic Examination; D010629:Phenformin / Q000009:adverse effects
D007004:Hypoglycemic Agents; D010629:Phenformin; D002747:Chlorpropamide