Successful treatment of Pseudomonas aeruginosa septicaemia and meningitis with neutropenia--the presenting feature of hypogammaglobulinaemia.
A neutropenic child of 20 months suffered generalized infection with Pseudomonas aeruginosa, involving the bloodstream and the meninges. This was successfully treated with intravenous and intrathecal antibiotics and granulocyte transfusions before granulopoiesis recovered spontaneously. No immunoglobulin replacement was given during the acute episode, as the diagnosis of X-linked hypogammaglobulinaemia was made subsequently.
D000361:Agammaglobulinemia / Q000150:complications* / Q000188:drug therapy; D000380:Agranulocytosis / Q000209:etiology*; D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D006098:Granulocytes; D007074:Immunoglobulin G / Q000627:therapeutic use; D008581:Meningitis / Q000188:drug therapy*; D009503:Neutropenia / Q000209:etiology*; D011552:Pseudomonas Infections / Q000188:drug therapy*; D018805:Sepsis / Q000188:drug therapy*; D014031:Tobramycin / Q000627:therapeutic use*
D000900:Anti-Bacterial Agents; D007074:Immunoglobulin G; D014031:Tobramycin