Chromosomal damage induced by some ergot derivatives in vitro.
Three ergot derivatives, dihydroergotoxine, ergotamine and methysergide, were tested for their ability to induce chromosomal damage in human lymphocytes in culture. The aberration frequency was significantly increased after treatment of the cells with 0.1 microng/ml, 0.25 microng/ml and 0.5 microng/ml of each drug. However the degree of damage was considerably less than that produced by 0.1 mg/ml to 0.5 mg/ml of caffeine, which was used as a positive control and is a known mutagen in this test-system.
D002110:Caffeine / Q000494:pharmacology; D002478:Cells, Cultured; D002869:Chromosome Aberrations; D002875:Chromosomes / Q000187:drug effects*; D004088:Dihydroergotoxine / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D004876:Ergot Alkaloids / Q000494:pharmacology*; D004878:Ergotamine / Q000494:pharmacology; D006801:Humans; D008214:Lymphocytes / Q000187:drug effects; D008784:Methysergide / Q000494:pharmacology
D004876:Ergot Alkaloids; D004088:Dihydroergotoxine; D002110:Caffeine; D004878:Ergotamine; D008784:Methysergide