title: Hormonal regulation of thermogenesis in goslings. The effects of blockade with thiouracil and propranolol.
abstract: Hormonal regulation of thermogenesis in goslings. The effects of blockade with thiouracil and propranolol. Acta Physiol. Pol. 1977, 28 (1): 51-60. The experiments were carried out on 90 male goslings of White Italian breed. In goslings 5 to 7 and 18 to 21-day-old thiouracil (6 mg/100 g i.p., for 3 consecutive days) diminished the cold-induced increase in the metabolic rate. At the end of 1.5 h exposure to 5 degrees C a small but statistically significant drop of body temperature in the thiouracil-treated goslings was noted. Propranolol treatment (2 mg/kg s.c.) had no clear effect neither on body temperature of cold exposed goslings nor on the cold-induced increase in the metabolic rate. The drug caused a significant decrease in the plasma free fatty acid (FFA) levels only in the goslings kept at thermoneutrality. In those exposed to 5 degrees C the plasma FFA levels rose both in the control and propranolol-treated goslings. This suggests that the cold-induced lipolysis in the goslings may be accomplished without mediation of noradrenaline.
mesh_terms: D000367:Age Factors; D000818:Animals; D013956:Antithyroid Agents; D001831:Body Temperature / Q000187:drug effects*; D001833:Body Temperature Regulation / Q000187:drug effects; D004837:Epinephrine / Q000097:blood; D005230:Fatty Acids, Nonesterified / Q000097:blood; D005777:Geese / Q000502:physiology*; D008297:Male; D009638:Norepinephrine / Q000097:blood; D011433:Propranolol / Q000494:pharmacology*; D013889:Thiouracil / Q000494:pharmacology*; D013961:Thyroid Gland / Q000187:drug effects*; D013963:Thyroid Hormones / Q000494:pharmacology
chemical_list: D013956:Antithyroid Agents; D005230:Fatty Acids, Nonesterified; D013963:Thyroid Hormones; D013889:Thiouracil; D011433:Propranolol; D009638:Norepinephrine; D004837:Epinephrine