title: [Hexobarbital-oxidation in vivo and in vitro in rats with bile duct ligation or ANIT-cholestasis (author's transl)].
abstract: Pharmacokinetics of hexobarbital in rats is not influenced by ligature of the common bile duct or by ANIT-cholestasis. Additional in vitro experiments with isolated liver microsomes show only slight changes of hexobarbital metabolism.
mesh_terms: D015058:1-Naphthylisothiocyanate; D000818:Animals; D001711:Biotransformation; D002779:Cholestasis / Q000139:chemically induced / Q000378:metabolism*; D003135:Common Bile Duct / Q000378:metabolism; D004195:Disease Models, Animal; D006591:Hexobarbital / Q000378:metabolism*; D066298:In Vitro Techniques; D008026:Ligation; D008297:Male; D008862:Microsomes, Liver / Q000378:metabolism; D051381:Rats; D013861:Thiocyanates
chemical_list: D013861:Thiocyanates; D015058:1-Naphthylisothiocyanate; D006591:Hexobarbital
vernacular_title: Hexobarbital-Oxidation in vivo und in vitro bei Choledochusligatur und ANIT-Cholestase der Ratte.