[Effect of the pH of the medium on the growth of a carminomycin producer and on the biosynthesis of the carminomycin complex].
The effect of the nutrient medium acidity on the growth of the carminomycin-producing organism and formation of the carminomycin complex with its aid was studied. Satisfactory development of the organism was observed when pH of the nutrient medium on the culture inoculation was 4.9 to 8.5. A shift in the alkaline and acid values of pH to 6.3--6.4 was registered during the first 24 hours of the culture growth. The biosynthesis of carminomycin depended on the culture growth time and pH value of the nutrient medium and culture fluid during the fermentation process. Maximum production of the carminomycin complex and its active components was observed on the 7th--8th day of the culture growth. The medium reaction close to the neutral one was optimal for biosynthesis of the carminomycin complex and its active components. Under acid, as well as alkaline conditions the antibiotic production was markedly lower.
D000192:Actinomycetales / Q000254:growth & development* / Q000378:metabolism; D000903:Antibiotics, Antineoplastic / Q000096:biosynthesis*; D002360:Carubicin / Q000096:biosynthesis*; D003470:Culture Media / Q000494:pharmacology*; D005285:Fermentation; D013997:Time Factors
D000903:Antibiotics, Antineoplastic; D003470:Culture Media; D002360:Carubicin
Vliianie pH sredy na rost produtsenta karminomitsina i biosintez karminomitsinovogo kompleksa