Reaction of foetal tissues to intra-uterine subcutaneous injection of barium sulphate.
Subpannicular injection of sterile barium sulphate in newborn rabbits produces an acute inflammatory response which is clearly seen at 24 hr and is well established at 48 hr. The processes of repair has begun by the 4th day with the appearance of proliferating capillaries and fibroblasts. In rabbit foetuses both vascular and cellular components of the acute inflammatory response are more prominent and appear earlier than in newborn rabbits, being well developed within 24 hr. The process of repair also begins earlier, proliferation of capillaries and fibroblasts being already prominent by 48 hr. By the 4th day the lesion is compact, less cellular and relatively avascular.
D000818:Animals; D000831:Animals, Newborn / Q000502:physiology*; D001466:Barium Sulfate / Q000494:pharmacology; D002196:Capillaries / Q000502:physiology; D005260:Female; D005333:Fetus / Q000187:drug effects / Q000473:pathology / Q000502:physiology*; D007249:Inflammation / Q000139:chemically induced / Q000473:pathology / Q000503:physiopathology*; D007279:Injections, Subcutaneous; D007962:Leukocytes / Q000502:physiology; D008264:Macrophages / Q000502:physiology*; D009504:Neutrophils / Q000502:physiology*; D011247:Pregnancy; D011817:Rabbits; D013997:Time Factors
D001466:Barium Sulfate