[Glycoprotein components of the skin under normal conditions and in several types of pathology].
Content of sialic acids was increased 2.9-3.4-fold in soluble fraction of pathologically altered skin (parakeratotoic scales in psoriasis and allergo dermatoses) as compared with a skin of healthy persons. In parakeratotic scales 7-11 zones of PAS (positive glycoproteins) were found by polyacrylamide gel disc electrophoresis; they occurred in skin of healthy persons only in several cases. Hemoglobin-binding activity (haptoglobin) was observed in pathologically altered skin of 64-93% patients with psoriasis; it was not found in healthy persons. The spectrum of haptoglobin fractions in skin correlated with its phenotype in blood.
D055598:Chemical Phenomena; D002621:Chemistry; D003876:Dermatitis, Atopic / Q000378:metabolism*; D006023:Glycoproteins / Q000032:analysis* / Q000378:metabolism; D006242:Haptoglobins / Q000032:analysis; D006651:Histocytochemistry; D006801:Humans; D010503:Periodic Acid-Schiff Reaction; D011565:Psoriasis / Q000378:metabolism*; D012794:Sialic Acids / Q000032:analysis; D012867:Skin / Q000032:analysis* / Q000378:metabolism
D006023:Glycoproteins; D006242:Haptoglobins; D012794:Sialic Acids
O glikoproteidnykh komponentakh kozhi v norme i pri nekotorykh vidakh patologii.