title: [Quantitative IgM-testing and prenatal rubella infection (author's transl)].
abstract: Cord blood of 686 newborns was tested for IgM-levels in connection with an epidemic occurrance of rubella infection in Bonn and its vicinity. In 17 samples IgM was higher than 30 mg/100 ml and in 102 samples higher than 20 mg/100 ml. In 121 cases the cord blood was examined for rubella antibodies and in 85 children it was also checked for the persistence of rubella antibodies at the end of the first six months of life. No unexpected prenatal rubella infection was found. Two children of this group had clinical and serological criteria for rubella embryopathy at birth. In addition 39 cases of verified rubella infections during pregnancy were investigated. In 13 cases abortion was performed during the first trimenon following a rubella infection; the presence of rubella virus embryotic tissue could be proven in 9 cases. A prenatal rubella infection became apparent by illness of the mother during the pregnancy and/or embryopathy of the newborn in 26 children. In 16 of these children prenatal rubella infection was confirmed by the detection of rubella specific IgM which was associated in all instances with elevated levels of IgM, and/or the persistence of rubella antibodies after the sixth month of life. The remaining 10 children had neither clinical nor serological signs. The mothers of 9 of these children had been ill after the 16th week of pregnancy. In at least 21 cases (81%) of 26 maternal rubella infections during the first trimenon of pregnancy the virus passed the placenta. In 13 cases the pregnancy was interrupted; of the remaining 13, 6 children (46%) had embryopathy.
mesh_terms: D000029:Abortion, Legal; D000914:Antibodies, Viral / Q000032:analysis; D004622:Embryo, Mammalian; D005260:Female; D005315:Fetal Diseases / Q000276:immunology; D005860:Germany, West; D006801:Humans; D007075:Immunoglobulin M / Q000032:analysis*; D007223:Infant; D007231:Infant, Newborn; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000175:diagnosis / Q000276:immunology*; D012409:Rubella / Q000175:diagnosis / Q000453:epidemiology / Q000276:immunology*; D012412:Rubella virus
chemical_list: D000914:Antibodies, Viral; D007075:Immunoglobulin M
vernacular_title: Quantitative IgG-Bestimmung und pränatale rötelninfektion.