[Biological criteria for the surveillance of hydatidiform moles and choriocarcinomas].
Secretion of choriogonadotropin (hCG) remains until now the more accurate biochemical label of trophoblastic disease and a close follow-up is possible by means of sensitive and specific radioimmunoassays. After hydatidiform moles, drawing the decreasing curve of hCG concentrations by weekly measurements in plasma or urine, would generally allow distinguishing within a few weeks cases with and without retention of active trophoblastic tissue, although in only 30 p. 100 of moles hCG spontaneously disappears within a month. In some choriocarcinoma under therapy, low persisting hCG levels (lower than 100 or 50 I.U./24 hours) could only be evidenced by repeated radioimmunoassays. Even with apparently physiological hLH/hCG concentrations, the use of anti-beta hCG antiserum could demonstrate, if any, a secretion of choriogonadotropin. In castrated women the same technique would elude the interference of hLH and make easier the diagnostic of relapses.
D002369:Castration; D002822:Choriocarcinoma / Q000188:drug therapy / Q000378:metabolism*; D006063:Chorionic Gonadotropin / Q000097:blood / Q000378:metabolism* / Q000652:urine; D004798:Enzymes / Q000378:metabolism; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D006828:Hydatidiform Mole / Q000378:metabolism*; D006908:Hydroxyprogesterones / Q000378:metabolism; D007986:Luteinizing Hormone / Q000097:blood / Q000652:urine; D009365:Neoplasm Regression, Spontaneous / Q000378:metabolism; D010928:Placental Lactogen / Q000378:metabolism; D011247:Pregnancy; D011374:Progesterone / Q000378:metabolism; D013997:Time Factors; D014327:Trophoblasts / Q000378:metabolism; D014594:Uterine Neoplasms / Q000188:drug therapy / Q000378:metabolism*
D006063:Chorionic Gonadotropin; D004798:Enzymes; D006908:Hydroxyprogesterones; D011374:Progesterone; D007986:Luteinizing Hormone; D010928:Placental Lactogen
Les critères biologiques de surveillance des môles hydatiformes et des choriocarcinomes.