The neurotoxicity of 5,7-dihydroxytryptamine in the mouse atrium: protection by 1-phenyl-3-(2-thiazolyl)-2-thiourea and by ethanol.
1-Phenyl-3-(2-thiazolyl)-2-thiourea (200 mg/kg, 1 h) protected the adrenergic nerve plexus in the mouse atrium against the destructive action of i.v. 5,7-dihydroxytryptamine. Protection was also observed with ethanol (4 g/kg, 1 h) and with nialamide (50 mg/kg, 2 h).
D015115:5,6-Dihydroxytryptamine / Q000031:analogs & derivatives / Q000037:antagonists & inhibitors* / Q000494:pharmacology; D000818:Animals; D004347:Drug Interactions; D000431:Ethanol / Q000494:pharmacology*; D006325:Heart Atria / Q000294:innervation; D008297:Male; D051379:Mice; D009410:Nerve Degeneration / Q000187:drug effects; D010668:Phenylthiazolylthiourea / Q000494:pharmacology*; D010670:Phenylthiourea / Q000031:analogs & derivatives*; D013564:Sympathetic Nervous System / Q000187:drug effects*; D014363:Tryptamines / Q000037:antagonists & inhibitors*
D014363:Tryptamines; D010668:Phenylthiazolylthiourea; D000431:Ethanol; D010670:Phenylthiourea; D015115:5,6-Dihydroxytryptamine