Effects of bovine SRS-A (SRS-Abov) on bovine respiratory tract and lung vasculature in vitro.
Evidence from isolated bovine pulmonary vessels and respiratory smooth muscles suggests that bovine slow-reacting substance of anaphylaxis (SRS-Abov) may contribute to bronchoconstriction and pulmonary oedema during anaphylaxis in cattle. Bovine bronchus is sensitive to low concentrations of SRS-Abov and is considerably more sensitive than trachea. Contraction of the calf bronchus to SRS-Abov can be antagonized by sodium meclofenamate, suggesting prostaglandins may be involved in the contraction. Bovine pulmonary artery did not contract to SRS-A at any of the concentrations examined. None of the proposed SRS-A receptor antagonists, FPL 55712, PR-D-92-EA, or sodium meclofenamate, inhibit the effects of bovine SRS-A in bovine pulmonary vein.
D000818:Animals; D001980:Bronchi / Q000187:drug effects; D002417:Cattle; D006632:Histamine / Q000494:pharmacology; D006633:Histamine Antagonists / Q000494:pharmacology; D007082:Ileum / Q000187:drug effects; D066298:In Vitro Techniques; D008168:Lung / Q000098:blood supply*; D008297:Male; D009119:Muscle Contraction / Q000187:drug effects*; D009130:Muscle, Smooth / Q000187:drug effects*; D011651:Pulmonary Artery / Q000187:drug effects; D011667:Pulmonary Veins / Q000187:drug effects; D012137:Respiratory System / Q000187:drug effects*; D013189:SRS-A / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D012701:Serotonin / Q000494:pharmacology; D012702:Serotonin Antagonists; D014132:Trachea / Q000187:drug effects
D006633:Histamine Antagonists; D013189:SRS-A; D012702:Serotonin Antagonists; D012701:Serotonin; D006632:Histamine