title: Erythema elevatum diutinum, cryoglobulinaemia, and fixed urticaria on cooling.
abstract: A mixed cryoglobulin (IgG/IgM) was detected in a patient with erythema elevatum diutinum. Cold exposure activated the complement system and provoked a fixed urticarial reaction with the histology of a leukocytoclastic vasculitis.
mesh_terms: D003080:Cold Temperature; D003450:Cryoglobulins / Q000032:analysis; D004890:Erythema / Q000150:complications* / Q000276:immunology; D005260:Female; D006801:Humans; D007074:Immunoglobulin G / Q000032:analysis; D007075:Immunoglobulin M / Q000032:analysis; D008875:Middle Aged; D010265:Paraproteinemias / Q000150:complications*; D014581:Urticaria / Q000209:etiology* / Q000473:pathology
chemical_list: D003450:Cryoglobulins; D007074:Immunoglobulin G; D007075:Immunoglobulin M