Granulomas and cholestatic--hepatocellular injury associated with phenylbutazone. Report of two cases.
A combined cholestatic-hepatocellular injury and noncaseating granulomas occurred in two patients 1 and 4 weeks after phenylbutazone therapy. Both patients were jaundiced, one had a macular rash, and both had peripheral blood eosinophilia. Symptoms and signs subsided, and abnormal findings from tests of hepatic function rapidly returned to normal following withdrawal of the drug. Sections of liver biopsy specimens 6 months later showed no granulomas or other pathologic changes. Previously reported cases are reviewed.
D000368:Aged; D056486:Chemical and Drug Induced Liver Injury / Q000473:pathology; D002707:Chlordiazepoxide / Q000009:adverse effects / Q000627:therapeutic use; D002779:Cholestasis / Q000139:chemically induced*; D003975:Diazepam / Q000009:adverse effects / Q000627:therapeutic use; D006099:Granuloma / Q000139:chemically induced* / Q000473:pathology; D006801:Humans; D008099:Liver / Q000187:drug effects* / Q000473:pathology; D008107:Liver Diseases / Q000473:pathology; D008297:Male; D008875:Middle Aged; D010113:Oxyphenbutazone / Q000009:adverse effects / Q000627:therapeutic use; D010653:Phenylbutazone / Q000009:adverse effects* / Q000627:therapeutic use
D002707:Chlordiazepoxide; D010653:Phenylbutazone; D010113:Oxyphenbutazone; D003975:Diazepam