[Effect of 8-methoxypsoralen and blacklight on microorganisms in vitro and in experimental trichophytosis in guinea pigs].
The lack of experimental test models causes problems in comparative evaluation of photodynamic effects of 8-MOP and its possible derivatives after irradiation with blacklight or other irradiation sources. In our experiments in vitro, tests with various microorganisms and the in vivo model of experimental dermatophytosis in guinea pigs by Trichophyton mentagrophytes appeared to be suitable. In vivo, 8-MOP was applicated orally and topically in two formulations.
D000284:Administration, Oral; D000818:Animals; D004353:Drug Evaluation, Preclinical; D004655:Emulsions; D006168:Guinea Pigs; D007259:Infrared Rays; D008730:Methoxsalen / Q000008:administration & dosage / Q000494:pharmacology*; D010787:Photosensitivity Disorders; D012996:Solutions; D014005:Tinea / Q000188:drug therapy / Q000532:radiotherapy / Q000628:therapy*; D014249:Trichophyton / Q000187:drug effects* / Q000528:radiation effects*
D004655:Emulsions; D012996:Solutions; D008730:Methoxsalen
Zur Wirkung von 8-Methoxypsoralen (8-MOP) und Blacklight auf Mikroorganismen in vitro und den Ablauf der experimentellen Meerschweinchen-Trichophytie