[Light- and electron microscopical investigation on the pathogenesis of Kaposi's sarcoma (author's transl)].
In Kaposi's sarcoma (K.S.) the regular metabolism between endothelial cell, extracellular matrix and fibrocyte is disturbed. Thereby the composition of the extracellular matrix change and via a feed-back to the CNS and hormonal system in return changes of endothelial cells and fibrocytes appear. Processing of misinformation sum up in transformation of fibrocytes to tumor cells and destruction of endothelial cells. Initial a widening of the interendothelial borders of the capillary bed seem to be of great importance for the pathogenesis of K.S., because for long time spaces lymphedemas preceed the tumor. With this immunoreactions occur which probably are accompanied by autoimmuno-processes
D000368:Aged; D002471:Cell Transformation, Neoplastic; D004727:Endothelium / Q000378:metabolism; D005347:Fibroblasts / Q000378:metabolism; D006801:Humans; D008297:Male; D012514:Sarcoma, Kaposi / Q000209:etiology* / Q000378:metabolism / Q000648:ultrastructure; D012867:Skin / Q000648:ultrastructure
Licht- und elektronenoptische Untersuchungen zur Pathogenese des Kaposi-Sarkoms