[Hormonal sensitivity of mammary adenocarcinoma in rats and the capacity of the sulfhydryl groups of this tumor for bindig by various antineoplastic drugs].
A correlation was studied between the hormone-dependence of DMBA induced mammary carcinomas in rats and their in-vitro sensitivity to thiophosphamide, benzo-TEPA, sarcolysin and ederpine according to the responsiveness of SH-groups of tumor tissues. A reliable positive correlation was found between the hormone-dependence of neoplasms and their sensitivity to thiophosphamide: the more rapid was tumor regression after ovariectomy, the higher the precentage of in vitro binding of tissue homogenate sulfhydrile groups by the substance. In terms of other alkylating substances this correlation was found to be unreliable. A conclusion is made that the test of adenocarcinoma sulfhydrile groups binding to thiophosphamide may enable one to judge the hormonal responsiveness of mammary gland neoplasms.
D000230:Adenocarcinoma / Q000188:drug therapy / Q000378:metabolism*; D000477:Alkylating Agents / Q000494:pharmacology* / Q000627:therapeutic use; D000818:Animals; D002369:Castration; D005260:Female; D008325:Mammary Neoplasms, Experimental / Q000188:drug therapy / Q000378:metabolism*; D051381:Rats; D011955:Receptors, Drug / Q000187:drug effects; D013438:Sulfhydryl Compounds / Q000378:metabolism*
D000477:Alkylating Agents; D011955:Receptors, Drug; D013438:Sulfhydryl Compounds
Gormonal'naia chuvstvitel'nost' adenocartsinom molochnykh zhelez krys i sposobnost' SH-grupp etikh opukholeĭ k sviazyvaniiu nekotorymi antiblasticheskimi preparatami.