title: Interrelation between two anticomplement cobra venom factors isolated from crude Naja naja cobra venom.
abstract: Two moieties occurring in crude Naja naja cobra venom were found to possess anticomplement activity. Both materials possessed similar molecular weights and specific activities but dissimilar elution profiles upon ion-exchange chromatography. The anticomplement activities of these materials were maintained upon digestion with neuraminidase, and their elution profiles from cation-exchange chromatography became identical after this treatment. It was concluded that the differences between the two anticomplement materials were due to their different sialic acid contents.
mesh_terms: D000818:Animals; D002848:Chromatography, DEAE-Cellulose; D002850:Chromatography, Gel; D002852:Chromatography, Ion Exchange; D003168:Complement Fixation Tests; D003169:Complement Inactivator Proteins; D004347:Drug Interactions; D004912:Erythrocytes / Q000187:drug effects; D006461:Hemolysis; D006801:Humans; D006868:Hydrolysis; D066298:In Vitro Techniques; D009439:Neuraminidase; D012756:Sheep; D012910:Snake Venoms / Q000032:analysis / Q000494:pharmacology*
chemical_list: D003169:Complement Inactivator Proteins; D012910:Snake Venoms; D009439:Neuraminidase