Fibrinolysis associated with human neoplasia: production of plasminogen activator by human tumours.
The plasminogen-dependent fibrinolytic activity of several human tumours has been studied. The following neoplastic tissues, which were obtained from cancer patients by either surgery or biopsies, were examined: cervical, mammary, prostatic, ovarian, lung carcinomas, melanoma, basalioma. Fibrinolysis was measured in lysates either of tumour tissue specimens or of respective cell cultures. This measurement was based on release of radioactivity from 125I-fibrin-coated Petri dishes. All examined tumours showed elevated levels of plasminogen-dependent fibrinolytic activity. However, normal control tissues had little or no activity. These results indicate that the fibrinolysis might be useful in differentiating between malignant and normal tissues.
D001943:Breast Neoplasms / Q000032:analysis; D002280:Basal Cell Carcinoma / Q000032:analysis; D002478:Cells, Cultured; D005260:Female; D005342:Fibrinolysis; D006801:Humans; D008297:Male; D008545:Melanoma / Q000032:analysis; D009369:Neoplasms / Q000378:metabolism*; D010051:Ovarian Neoplasms / Q000032:analysis; D010960:Plasminogen Activators / Q000096:biosynthesis*; D011471:Prostatic Neoplasms / Q000032:analysis; D002583:Uterine Cervical Neoplasms / Q000032:analysis
D010960:Plasminogen Activators