title: [Characteristics of the action of antibiotics in an experimental process caused by Cl. histolyticum].
abstract: The cells of Cl. histolyticum isolated from the muscular tissue of albino mice infected with the microbe and treated with oxyglucocycline or cephaloridin were similar to each other and the cells of the initial strain with respect to their morphological features, growth character on liquid and solid media and saccharolytic activity. The strains isolated from the animals treated with oxyglucocycline were characterized by lower gelatinolytic, hemolytic, caseinolytic and (to a less extent) collogenolytic activity. The strains isolated from the animals treated with cephaloridin slightly differed from the initial strain by their cultural properties. The lethal effect of the total toxin of both variants of the strains studied were similar, only the time of the animal's death being different. The data of the study may serve as one of the explanations of various effects of the antibiotics differing in their modes of action on the microbial cell in cases of infection caused by Cl. histolyticum.
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D001427:Bacterial Toxins / Q000494:pharmacology; D001433:Bacteriolysis / Q000187:drug effects; D002509:Cephaloridine / Q000627:therapeutic use; D003013:Clostridium / Q000187:drug effects / Q000302:isolation & purification; D003015:Clostridium Infections / Q000188:drug therapy* / Q000382:microbiology; D051379:Mice; D008815:Mice, Inbred Strains; D009132:Muscles / Q000382:microbiology; D010118:Oxytetracycline / Q000031:analogs & derivatives* / Q000627:therapeutic use; D013997:Time Factors
chemical_list: D000900:Anti-Bacterial Agents; D001427:Bacterial Toxins; C012471:oxyglucocycline; D002509:Cephaloridine; D010118:Oxytetracycline
vernacular_title: Osobennosti deĭstviia antiboiotikov pri éksperimental'nom protsesse, vyzuznnom Cl. histolyticum