Intravascular coagulation resulting from intravenous injection of C. parvum in mice.
In mice, i.v. C. parvum induces intravascular coagulation. This is a prolonged reaction lasting up to 7 days. It results in thrombosis in hepatic vessels with consequent hepatic necrosis, and thrombosis in pulmonary and splenic vessels. This may be important in the assessment of the tumour-inhibitory activity of C. parvum.
D000818:Animals; D001772:Blood Cell Count; D001777:Blood Coagulation; D005260:Female; D007275:Injections, Intravenous; D008099:Liver / Q000098:blood supply / Q000473:pathology; D008168:Lung / Q000098:blood supply / Q000473:pathology; D051379:Mice; D008810:Mice, Inbred C57BL; D011425:Propionibacterium acnes; D013154:Spleen / Q000098:blood supply / Q000473:pathology; D013927:Thrombosis / Q000209:etiology; D013997:Time Factors