[Characteristics of the amino acid spectrum of blood serum in diabetes mellitus].
The content of the following 10 amino acids was investigated by means of a microbiological method (with the use of auxotrophic E. coli mutants) in 23 patients with diabetes mellitus with fatty infiltration of the liver and in 27 patients without it: histidine, proline, methionine, cystine, tryptophane, leucine, arginine, tyrosine, lysine, and phenylalanine. Results of study of the amino acid balance were compared with the morphological changes in the liver (the material was obtained by biopsy). All the diabetic patients displayed an increase in the proline, tryptophane, tyrosine, leucine, and cystine content, and a reduction of phenylalanine and lysine level. Fatty hepatocyte infiltration was also accompanied by a significant elevation of methionine and a reduction of arginine content. A tendency to normalization of leucine and lysine only was seen after the treatment of diabetic patients with fatty hepatocyte infiltration; diabetic patients without any fatty infiltration showed normalization in the tyrosine, lysine content and a tendency to the normalization of the cystine, tryptophane level, but no change in the methionine content.
D000293:Adolescent; D000328:Adult; D000596:Amino Acids / Q000097:blood*; D048909:Diabetes Complications; D003920:Diabetes Mellitus / Q000097:blood*; D005234:Fatty Liver / Q000097:blood / Q000209:etiology / Q000473:pathology; D006801:Humans; D008099:Liver / Q000473:pathology; D008875:Middle Aged
D000596:Amino Acids
Osobennosti aminokislotnogo spektra syvorotki krovi pri sakharnom diabete.