Binding of pyridine derivatives to cytochrome P-450.
The spectral binding constants, Ks, of pyridine, methylpyridine, and dimethylpyridines were determined. The Ks values of the compounds were discussed in terms of mechanisms of possible bonding to cytochrome P-450.
D000818:Animals; D001665:Binding Sites; D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism*; D006418:Heme / Q000378:metabolism; D007700:Kinetics; D008297:Male; D008862:Microsomes, Liver / Q000378:metabolism; D011485:Protein Binding; D011725:Pyridines / Q000378:metabolism*; D051381:Rats
D011725:Pyridines; D006418:Heme; D003577:Cytochrome P-450 Enzyme System