Studies on bacterial cell wall inhibitors. III. 3-amino-3-deoxy-D-glucose, an inhibitor of bacterial cell wall synthesis.
It was shown that 3-amino-3-deoxy-D-glucose, one of the constituents of the kanamycin molecule and a metabolite of Bacillus sp., inhibits the bacterial synthesis of cell wall. The antibiotic (100 microgram/ml) significantly inhibits the growth of Staphylococcus aureus FDA 209P as well as the incorporation of DL-[14C]alanine into the acid-insoluble macromolecular fraction of its growing cells in the presence of chloramphenicol (100 microgram/ml). In contrast, the antibiotic does not affect the incorporation of [3H]thymidine, [3H]uridine and L-[14C]leucine. The other constituents of kanamycin, 6-amino-6-deoxy-D-glucose and deoxystreptamine do not inhibit the synthesis of bacterial cell wall peptidoglycan.
D000409:Alanine / Q000378:metabolism; D001426:Bacterial Proteins / Q000096:biosynthesis; D002473:Cell Wall / Q000187:drug effects / Q000502:physiology*; D004269:DNA, Bacterial / Q000096:biosynthesis; D005944:Glucosamine / Q000494:pharmacology*; D007612:Kanamycin / Q000494:pharmacology; D007700:Kinetics; D007930:Leucine / Q000378:metabolism; D010457:Peptidoglycan / Q000096:biosynthesis; D012329:RNA, Bacterial / Q000096:biosynthesis; D013045:Species Specificity; D013211:Staphylococcus aureus / Q000187:drug effects / Q000502:physiology*; D013936:Thymidine / Q000378:metabolism; D014529:Uridine / Q000378:metabolism
D001426:Bacterial Proteins; D004269:DNA, Bacterial; D010457:Peptidoglycan; D012329:RNA, Bacterial; D007612:Kanamycin; D007930:Leucine; D005944:Glucosamine; D000409:Alanine; D013936:Thymidine; D014529:Uridine