Reye's syndrome: patient serum alters mitochondrial function and morphology in vitro.
A direct relationship between a putative Reye's syndrome "serum factor" and generalized mitochondrial damage has been demonstrated in vitro. The clinical features of Reye's syndrome may be secondary to disrupted mitochondrial structure and a consequent impairment of energy-linked functions involving many organs.
D000818:Animals; D002908:Chronic Disease; D004734:Energy Metabolism; D006801:Humans; D008107:Liver Diseases / Q000097:blood; D008930:Mitochondria, Liver / Q000378:metabolism* / Q000648:ultrastructure; D010101:Oxygen Consumption; D051381:Rats; D012202:Reye Syndrome / Q000097:blood* / Q000378:metabolism