title: Toxic effects of chlorinated cake flour in rats.
abstract: Four experiments were conducted using weanling Wistar rats to determine whether chlorinated cake flour or its constituents were toxic. Levels of 0.2 and 1.0% chlorine added to unbleached cake flour significantly (p less than 0.01) reduced growth rate by 20.7 and 85.2% and increased liver weight relative to body weight by 16.7 and 25.3%, respectively. Lipids extracted from flour chlorinated at the same levels had similar effects. Rat chow diets containing 0.2 and 0.6% chlorine in the form of chlorinated wheat gluten reduced growth rate and increased liver weight as a percentage of body weight. A rat chow diet containing 0.2% chlorine as chlorinated flour lipids increased absolute liver weight by 40%, kidney by 20%, and heart by 10% compared to pair-fed controls.
mesh_terms: D000596:Amino Acids / Q000032:analysis; D000818:Animals; D001835:Body Weight / Q000187:drug effects; D002713:Chlorine / Q000009:adverse effects*; D004041:Dietary Fats; D004044:Dietary Proteins; D005433:Flour / Q000009:adverse effects* / Q000032:analysis; D005503:Food Additives / Q000009:adverse effects*; D008099:Liver / Q000187:drug effects / Q000378:metabolism / Q000473:pathology; D008297:Male; D009929:Organ Size / Q000187:drug effects; D051381:Rats
chemical_list: D000596:Amino Acids; D004041:Dietary Fats; D004044:Dietary Proteins; D005503:Food Additives; D002713:Chlorine