Elevated sister chromatid exchange rate in lymphocytes of subjects treated with arsenic.
An elevated sister chromatid exchange (SCE) rate was found in the lymphocytes of six patients treated with arsenic. All had stigmata of arsenic use as well as biopsy-proven skin cancers. The arsenic exposed patients had a mean of 14.00 SCE/mitosis while 44 normal controls had a mean of 5.8 SCE/mitosis. Chromosome breakage analysis revealed no difference between the two groups. SCE rate has been shown to be elevated in a variety of systems where cell cultures or experimental animals were exposed to known mutagens and carcinogens. We suggest that the relationship carcinogen exposure-elevated SCE rate-cancer may also be valid in humans treated with arsenic.
D000328:Adult; D000368:Aged; D001151:Arsenic / Q000009:adverse effects*; D002842:Chromatids / Q000187:drug effects*; D002869:Chromosome Aberrations; D003434:Crossing Over, Genetic / Q000187:drug effects*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009153:Mutagens; D012878:Skin Neoplasms / Q000139:chemically induced
D009153:Mutagens; D001151:Arsenic