The combined surgical and chemotherapeutic approach to non-seminomatous cancer of the testicle.
Of 250 testicular tumors treated up to May 1975 233 (93.2%) were germ cell and 17 (6.8%) non-germ cell tumors. Reexamining the histology of the last 123 patients only 29.3% had pure seminomas and 70.7% had non-seminomatous tumors. The results of regimens of combined surgical (extended semicastration and lymphadenectomy) and chemotherapeutic (triple-drug as well as Ifosfamid in combinations with low-dose radiafor stage II (37.5%) and stage II (16.7%). There were good results after 96 transperitoneal bilateral lymphadenectomies. But even in stages II and III results were achieved which would not have been possible without lymphadenectomy. It is pointed out that in the future, with improvements in cytostatic therapy, even better results including treatment of stage IV tumors can be expected.
D002699:Chlorambucil / Q000627:therapeutic use; D003609:Dactinomycin / Q000627:therapeutic use; D004359:Drug Therapy, Combination; D004407:Dysgerminoma / Q000628:therapy*; D006801:Humans; D007069:Ifosfamide / Q000627:therapeutic use; D008197:Lymph Node Excision / Q000009:adverse effects; D008207:Lymphatic Metastasis; D008297:Male; D008727:Methotrexate / Q000627:therapeutic use; D011183:Postoperative Complications; D011379:Prognosis; D012187:Retroperitoneal Space / Q000601:surgery; D013724:Teratoma / Q000628:therapy*; D013736:Testicular Neoplasms / Q000188:drug therapy / Q000601:surgery / Q000628:therapy*
D002699:Chlorambucil; D003609:Dactinomycin; D007069:Ifosfamide; D008727:Methotrexate