A dehydrogenase system to demonstrate oxidation of amphetamine and related compounds by rat brain homogenate.
Amphetamine, ephedrine, mescaline and chlorpromazine act as substrate for dehydrogenase system of rat brain homogenate. This system appears quite different from the usual deaminating process of these compounds, which required NADP and oxygen. The present system proceeds more rapidly in anaerobic condition.
D000661:Amphetamine / Q000378:metabolism*; D000818:Animals; D001921:Brain / Q000201:enzymology*; D002746:Chlorpromazine / Q000378:metabolism; D003913:Dextroamphetamine / Q000378:metabolism; D004809:Ephedrine / Q000378:metabolism; D005562:Formazans / Q000378:metabolism; D066298:In Vitro Techniques; D008635:Mescaline / Q000378:metabolism; D010084:Oxidation-Reduction; D010088:Oxidoreductases / Q000378:metabolism*; D010100:Oxygen / Q000494:pharmacology; D051381:Rats; D014439:Tyramine / Q000378:metabolism
D005562:Formazans; D000661:Amphetamine; D010088:Oxidoreductases; D004809:Ephedrine; D008635:Mescaline; D010100:Oxygen; D003913:Dextroamphetamine; D002746:Chlorpromazine; D014439:Tyramine