Pharmacokinetic comparison of the one-point method with other methods in predicting steady state drug concentrations in multiple dosing.
Using blood level-time profiles of five different drugs, the maximum and minimum drug concentrations,c'max and c'min, were determined according to four different methods. It was demonstrated that the one-point method results in an acceptable estimate allowing prediction of steady state concentrations and adjustment of dose regimen based on one single blood level concentration determined during the later part of the first dosing interval, and utilizing literature on the biological half-life and the time to reach the peak. In case of renal impairment a correction can be made after determination of serum creatinine in the one blood sample taken.
D004334:Drug Administration Schedule; D006801:Humans; D007700:Kinetics; D008433:Mathematics; D008722:Methods; D008954:Models, Biological; D004364:Pharmaceutical Preparations / Q000008:administration & dosage / Q000097:blood*; D013997:Time Factors
D004364:Pharmaceutical Preparations