title: [Penetration of oleandomycin into the subarachnoid space of neurosurgical patients].
abstract: Penetration of oleandomycin into the subarachnoid space in neurosurgical patients treated with the drug administered orally and intramuscularly in doses of 375 and 500 mg respectively was studied. The oleandomycin levels in the blood and cerobrospinal fluid were determined after a single administration of the antibiotic at an interval of 30 minutes to 7 hours. A total of 52 observations were recorded. Relation between oleandomycin penetration into the cerebrospinal fluid from the blood and the administration route was shown. The index of penetration through the blood-liquor barrier for the antibiotic intramuscular or oral administration was 9--70 and 3--40 per cent respectively. The maximum concentrations of the drug in the liquor were found in the patients with the clinical picture of meningitis.
mesh_terms: D000284:Administration, Oral; D001927:Brain Diseases / Q000134:cerebrospinal fluid; D006801:Humans; D007273:Injections, Intramuscular; D008581:Meningitis / Q000188:drug therapy*; D009827:Oleandomycin / Q000097:blood / Q000134:cerebrospinal fluid* / Q000627:therapeutic use
chemical_list: D009827:Oleandomycin
vernacular_title: Proniknovenie oleandomitsina v subarakhoidal'nye prostranstva neĭrokhirurgicheskikh bol'nykh.