Inhibition of a lymphocyte membrane enzyme by delta9-tetrahydrocannabinol in vitro.
Delta-9-tetrahydrocannabinol (delta9-THC) inhibited the activity of lysolecithin acyl transferase, a membrane-bound lymphocyte enzyme, at concentrations above 1.3 muM. Stimulation of acyl transferase activity by concanavalin A, an early response in lymphocyte activation, was entirely abolished in the presence of delta9-THC.
D008243:1-Acylglycerophosphocholine O-Acyltransferase / Q000037:antagonists & inhibitors*; D000217:Acyltransferases / Q000037:antagonists & inhibitors*; D000818:Animals; D002462:Cell Membrane / Q000201:enzymology; D003208:Concanavalin A / Q000037:antagonists & inhibitors / Q000494:pharmacology; D013759:Dronabinol / Q000494:pharmacology*; D004789:Enzyme Activation; D008213:Lymphocyte Activation / Q000187:drug effects; D008214:Lymphocytes / Q000201:enzymology* / Q000276:immunology / Q000648:ultrastructure; D051379:Mice; D013154:Spleen / Q000201:enzymology
D003208:Concanavalin A; D013759:Dronabinol; D000217:Acyltransferases; D008243:1-Acylglycerophosphocholine O-Acyltransferase