Effect of bicarbonate and other buffers on choroid plexus Na+/K+pump.
The Na+/K+ pump on the apical membrane of the choroid plexus epithelium was found to be sensitive to bicarbonate. Glycodiazine, a non-volatile, lipid soluble buffer with a pK of 5.7, mimicked the effect of bicarbonate, and was transported across the epithelium in the same direction as sodium. These results are explained in terms of a Na+/H+ exchange mechanism on the basal-lateral membrane.
D000818:Animals; D001001:Anura; D001639:Bicarbonates / Q000494:pharmacology*; D001692:Biological Transport; D002021:Buffers; D002087:Butyrates / Q000494:pharmacology; D002462:Cell Membrane / Q000187:drug effects / Q000378:metabolism*; D002831:Choroid Plexus / Q000187:drug effects / Q000378:metabolism*; D004848:Epithelium / Q000187:drug effects / Q000378:metabolism; D007700:Kinetics; D008954:Models, Biological; D010042:Ouabain / Q000494:pharmacology; D011188:Potassium / Q000378:metabolism*; D012964:Sodium / Q000378:metabolism*
D001639:Bicarbonates; D002021:Buffers; D002087:Butyrates; D010042:Ouabain; D012964:Sodium; D011188:Potassium