Acute lethality of D- and L-ethionine in Swiss mice.
The acute, 7-day LD50 in Swiss mice of D-ethionine administered intraperitoneally, was determined as 185 mg/kg with 95% confidence limits of 163 and 210 mg/kg. L-ethionine, the stereoisomer, which is more potent in inhibiting liver RNA synthesis, was not lethal at 2500 mg/kg. This acute toxicity of D-ethionine was suppressed by L-methionine and adenine. Blood accumulation in the thoracic cavity and pericardium was the probable cause of death.
D000225:Adenine / Q000494:pharmacology; D000818:Animals; D005001:Ethionine / Q000008:administration & dosage / Q000037:antagonists & inhibitors / Q000633:toxicity*; D006321:Heart / Q000187:drug effects; D007928:Lethal Dose 50; D008297:Male; D008715:Methionine / Q000494:pharmacology; D051379:Mice; D012313:RNA / Q000096:biosynthesis; D013237:Stereoisomerism
D012313:RNA; D008715:Methionine; D000225:Adenine; D005001:Ethionine