Toxicity-related changes in benzene metabolism in vivo.
1. The influence of microsomal enzyme inducers and inhibitors on the metabolism of [U-14C]benzene in the rat was examined. 2. Pre-treatment of animals with the inhibitors piperonyl butoxide and cobaltous chloride tended to reduce the urinary excretion of metabolites in 24 h but increase the overall urinary excretion. Piperonyl butoxide tended to increase expired benzene. 3. Pre-treatment of animals with the inducer phenobarbital tended to increase urinary excretion of metabolites but decrease expired benzene, as did pre-treatment with benzene itself. 4. All pre-treatments appeared to increase the excretion of phenolic glucuronides, particularly benzene pre-treatment. Phenobarbital and benzene pre-treatment tended to increase phenylmercapturic acid excretion and benzene pre-treatment markedly increased excretion of quinol. 5. The results are discussed in relation to the effect of microsomal enzyme inhibitors and inducers on benzene-induced bone marrow toxicity.
D000111:Acetylcysteine / Q000031:analogs & derivatives / Q000378:metabolism; D000818:Animals; D001554:Benzene / Q000009:adverse effects / Q000378:metabolism* / Q000652:urine; D001944:Breath Tests; D003035:Cobalt / Q000494:pharmacology; D008297:Male; D010634:Phenobarbital / Q000494:pharmacology; D010636:Phenols / Q000652:urine; D010882:Piperonyl Butoxide / Q000494:pharmacology; D051381:Rats
D010636:Phenols; D003035:Cobalt; D001554:Benzene; D010882:Piperonyl Butoxide; D000111:Acetylcysteine; D010634:Phenobarbital