Healing of duodenal ulcer with an antacid regimen.
To determine whether a large-dose antacid regimen is effective in promoting healing of duodenal ulcer, 74 patients with endoscopically proved duodenal ulcer completed a 28-day double-blind clinical trial comparing such a regimen with an inert placebo. The ulcer healed completely in 28 of the 36 antacid-treated as compared to 17 of the 38 placebo-treated patients (P less than 0.005). The antacid regimen was not more effective than placebo in relieving ulcer symptoms. Presence or absence of symptoms during the fourth treatment week was a poor predictor of presence or absence of an ulcer crater. Ulcers of placebo-treated patients who smoked cigarettes were less likely to heal than those of nonsmokers (P = 0.03). Except for mild diarrhea, no side effects of the antacid regimen were observed. We conclude that a large-dose antacid regimen hastens the healing of duodenal ulcer.
D000284:Administration, Oral; D000328:Adult; D000368:Aged; D000536:Aluminum Hydroxide / Q000008:administration & dosage / Q000627:therapeutic use; D000863:Antacids / Q000008:administration & dosage / Q000627:therapeutic use*; D004338:Drug Combinations; D004381:Duodenal Ulcer / Q000175:diagnosis / Q000188:drug therapy*; D004386:Duodenum; D004724:Endoscopy; D005260:Female; D006801:Humans; D008274:Magnesium / Q000008:administration & dosage / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged; D012828:Silicones / Q000008:administration & dosage / Q000627:therapeutic use; D012907:Smoking / Q000150:complications; D013607:Tablets; D013997:Time Factors; D014945:Wound Healing
D000863:Antacids; D004338:Drug Combinations; D012828:Silicones; D013607:Tablets; D000536:Aluminum Hydroxide; D008274:Magnesium