[Lymphangiosis melanoblastomatosa].
After endolymphatic therapy and following surgical excision of lymphnodes in a patient with malignant melanoma the involved leg became edematous. In the edematous tissue there was a wide and diffuse spreading of the melanoma cells. Besides numerous cutaneous and subcutaneous metastatic nodules there were areas of blue-black coloring which showed a fine and reticular pattern. Histology confirmed that melanoma cells had filled up predominantly the superficial lymphatic vessels. Fluorescence histochemical investigations showed that these cells were viable and pigment-producing melanoma cells. There were also single enlarged melanocytes in the basal part of the epidermis with a high amount of fluorophores.
D000368:Aged; D006214:Hallux; D006801:Humans; D007866:Leg; D008197:Lymph Node Excision; D008202:Lymphangioma / Q000473:pathology*; D008207:Lymphatic Metastasis; D008208:Lymphatic System / Q000473:pathology; D008209:Lymphedema / Q000473:pathology*; D008297:Male; D008544:Melanocytes; D008545:Melanoma / Q000473:pathology* / Q000601:surgery; D008856:Microscopy, Fluorescence; D009262:Nails; D012867:Skin / Q000473:pathology; D012878:Skin Neoplasms / Q000473:pathology* / Q000601:surgery
Lymphangiosis melanoblastomatosa.