Effect of ageing on surface IgG of human peripheral lymphocytes.
An increase in the percentage of IgG bearing peripheral blood lymphocytes is observed in aged subjects as compared with young ones. Such a finding is probably due to the presence, in 'aged' sera, of a higher concentration of immune complexes, bound to lymphocytes through their Fc or Complement receptors.
D000328:Adult; D000368:Aged; D000375:Aging; D000936:Antigen-Antibody Complex; D001769:Blood; D002478:Cells, Cultured; D006801:Humans; D007072:Immunoglobulin D / Q000378:metabolism; D007074:Immunoglobulin G / Q000378:metabolism*; D007075:Immunoglobulin M / Q000378:metabolism; D008214:Lymphocytes / Q000276:immunology*; D011947:Receptors, Antigen, B-Cell / Q000378:metabolism*
D000936:Antigen-Antibody Complex; D007072:Immunoglobulin D; D007074:Immunoglobulin G; D007075:Immunoglobulin M; D011947:Receptors, Antigen, B-Cell