Calcium levulinate medication. A pitfall in the diagnosis of organic acidurias.
Five children, who received calcium levulinate (calcium 4-oxopentanoate) intravenously in pharmacological doses excreted in the following 24-h period both 4-oxopentanoic acid (3.5--11.0 mg/24 h) and 4-hydroxypentanoic acid (4.5--10.4 mg/24 h). Attention is drawn to the fact that in gas chromatographic-mass spectrometric systems these compounds closely resemble the two acids found in children with beta-ketothiolase deficiency.
D000102:Acetyl-CoA C-Acyltransferase / Q000172:deficiency; D002118:Calcium; D002264:Carboxylic Acids / Q000652:urine*; D002849:Chromatography, Gas / Q000379:methods; D003951:Diagnostic Errors; D005069:Evaluation Studies as Topic; D006801:Humans; D007231:Infant, Newborn; D007982:Levulinic Acids / Q000627:therapeutic use* / Q000652:urine; D008052:Lipid Metabolism, Inborn Errors / Q000175:diagnosis*; D013058:Mass Spectrometry / Q000379:methods
D002264:Carboxylic Acids; D007982:Levulinic Acids; D000102:Acetyl-CoA C-Acyltransferase; D002118:Calcium