title: Pharmacodynamics and pharmacokinetics of psycholeptic drugs in the course of radiation disease. The effect of premedication with cystamine on pharmacodynamics and Pharmacokinetics of nitrazepam.
abstract: Pharmacodynamics and pharmacokinetics of psycholeptic drugs in the course of radiation disease (I). Effect of premedication with cystamine on pharmacodynamics and pharmacokinetics of nitrazepam. Acta Physiol. Pol. 1977, 28 (2): 161--168. In the experiments carried out on rats the radiation disease was evoked by exposure to 600 R. The strongest radioprotective action of cystamine was found on the 3-rd day of radiation disease. The tendency to normalization of both the pharmacodynamics (exploring mobility and anticonvulsant action) and pharmacokinetics of nitrazepam in the animals premedicated with cystamine was described.
mesh_terms: D000818:Animals; D003538:Cystamine / Q000494:pharmacology*; D007700:Kinetics; D008297:Male; D009043:Motor Activity / Q000187:drug effects; D009567:Nitrazepam / Q000037:antagonists & inhibitors / Q000378:metabolism / Q000494:pharmacology*; D011832:Radiation Injuries / Q000517:prevention & control*; D011833:Radiation Injuries, Experimental; D051381:Rats
chemical_list: D009567:Nitrazepam; D003538:Cystamine