Toxicity of mild prenatal carbon monoxide exposure.
Rats prenatally exposed to a low concentration of carbon monoxide which results in carboxyhemoglobin levels equivalent to those maintained by human cigarette smokers, show reduced birth weight and decreased weight gain. Neuro-behavioral and biochemical testing of the offspring reveals lower behavioral activity levels through the preweaning period, altered central catecholamine activity, and reduction in total brain protein at birth.
D000818:Animals; D000831:Animals, Newborn / Q000502:physiology; D001522:Behavior, Animal / Q000187:drug effects; D001724:Birth Weight / Q000187:drug effects; D001835:Body Weight / Q000187:drug effects; D001921:Brain / Q000378:metabolism; D002248:Carbon Monoxide / Q000633:toxicity*; D004195:Disease Models, Animal; D004298:Dopamine / Q000378:metabolism; D005260:Female; D005333:Fetus / Q000187:drug effects*; D007980:Levodopa / Q000494:pharmacology; D008431:Maternal-Fetal Exchange; D009043:Motor Activity / Q000187:drug effects; D009419:Nerve Tissue Proteins / Q000378:metabolism; D009638:Norepinephrine / Q000378:metabolism; D011247:Pregnancy; D051381:Rats; D012907:Smoking / Q000150:complications
D009419:Nerve Tissue Proteins; D007980:Levodopa; D002248:Carbon Monoxide; D004298:Dopamine; D009638:Norepinephrine