Nonlinkage between C6 and chromosome 6 markers.
C6 typing was performed in a family material by two different techniques: serum or plasma samples were subjected either to high-voltage agarose gel electrophoresis or to isoelectric focusing in polyacrylamide gel slabs. Proteins with C6 activity were then visualized by a specific, hemolytic assay. In 81 unrelated adults within the family material the following allele frequencies were found: C6A:0.61 and C6B:0.39. Linkage studies exclude linkage between C6 and HLA region marker loci, and also between C6 and another chromosome 6 marker locus PGM3.
D000328:Adult; D002906:Chromosomes, Human, 6-12 and X; D003183:Complement C6; D003165:Complement System Proteins; D004587:Electrophoresis, Agar Gel; D005787:Gene Frequency; D008040:Genetic Linkage; D006680:HLA Antigens; D006801:Humans; D007525:Isoelectric Focusing
D003183:Complement C6; D006680:HLA Antigens; D003165:Complement System Proteins