Hepatic binding protein: the protective role of its sialic acid residues.
Removal of sialic acid from a specific hepatic binding protein virtually abolishes its capacity to bind certain asialoglycoproteins. The loss of this capacity is the result of competition for the binding sites by galactosyl residues, of hepatic binding protein, that become terminal after desialylation.
D000116:Acetylgalactosamine / Q000378:metabolism; D001665:Binding Sites; D002352:Carrier Proteins / Q000378:metabolism*; D006023:Glycoproteins / Q000378:metabolism*; D008099:Liver / Q000378:metabolism*; D008565:Membrane Proteins / Q000378:metabolism; D009077:Mucins / Q000378:metabolism; D009961:Orosomucoid / Q000378:metabolism; D012794:Sialic Acids / Q000378:metabolism*; D013329:Structure-Activity Relationship
D002352:Carrier Proteins; D006023:Glycoproteins; D008565:Membrane Proteins; D009077:Mucins; D009961:Orosomucoid; D012794:Sialic Acids; D000116:Acetylgalactosamine