title: Mouse chromosome translocations: visualization and analysis by electron microscopy of the synaptonemal complex.
abstract: Pachytene chromosomes of mice heterozygous for known translocations are clearly depicted by configurations of the synaptonemal complexes in spread (whole mount) preparations. In one autosomal and two X-autosome translocations analyzed, breakpoints are identifiable; localization by measurement agrees with mitotic data and shows the translocations to be reciprocal. Synapsis with the Y is inhibited in one translocation in which the breakpoint is the pairing region of the X.
mesh_terms: D000818:Animals; D002869:Chromosome Aberrations; D002875:Chromosomes / Q000648:ultrastructure*; D006579:Heterozygote; D008297:Male; D008540:Meiosis; D051379:Mice; D008854:Microscopy, Electron; D012730:Sex Chromosomes / Q000648:ultrastructure; D013090:Spermatocytes / Q000648:ultrastructure; D014178:Translocation, Genetic