[Synthesis and antimitotic activity of 3- and 5-halogen substituted bis-(2-aminophenyl)disulfides and corresponding N-alkyl derivatives].
In continuation of previus research on the antimitotic activity of aryldisulfides, the Authors have synthesised 3- and 5-chloro or fluoro substituted bis-(2-aminophenyl)disulfides and some of their 2-N-alkyl derivatives. These compounds were synthesised in order to submit them to biological testing to find any activity caused by halogen substituents on the benzene ring.
D055598:Chemical Phenomena; D002621:Chemistry; D004220:Disulfides / Q000138:chemical synthesis* / Q000494:pharmacology; D006868:Hydrolysis; D008938:Mitosis / Q000187:drug effects*
D004220:Disulfides
Sintesi e attività antimitotica di bis-(2-amminofenil)disolfuri 3- e 5-alogeno sostituiti e dei corrispondenti N-alchilderivati