[Effect of alpha-glycerophosphate on intracellular distribution of hexokinase in the tissue of fetal rabbits during acute hypoxia].
In experiments with 40 rabbit fetuses acute intrauterine hypoxia caused a redistribution of the hexokinase activity in brain and liver tissues towards an increase in the amount of the enzyme associated with mitochondria. Previous administration of alpha-glycerophosphate into rabbit female (at a dose of 1.3 g/kg of body weight) was accompanied by an increase in the hexokinase activity in liver mitochondria and in brain cytoplasmic fraction of fetus as well as in the total homogenate of both tissue. The phenomenon might be considered as a positive pattern in adaptation to hypoxia.
D000208:Acute Disease; D000818:Animals; D001921:Brain / Q000201:enzymology* / Q000648:ultrastructure; D002682:Chinchilla; D003593:Cytoplasm / Q000201:enzymology; D005260:Female; D005311:Fetal Hypoxia / Q000188:drug therapy* / Q000201:enzymology; D005994:Glycerophosphates / Q000627:therapeutic use*; D006593:Hexokinase / Q000378:metabolism*; D008099:Liver / Q000201:enzymology*; D008431:Maternal-Fetal Exchange; D008928:Mitochondria / Q000201:enzymology; D008930:Mitochondria, Liver / Q000201:enzymology; D011247:Pregnancy; D011817:Rabbits
D005994:Glycerophosphates; D006593:Hexokinase
Vliianie alpha-glitserofosfata na vnutrikletochnoe raspredelenie geksokinazy v tkaniakh plodov krolika pri ostroĭ gipoksii.