Functional assay of cytotoxic lymphocytes involved in antibody-mediated cytotoxicity in normal and rheumatoid subjects.
Antibody-mediated lymphocyte-induced cytotoxicity (K cell activity) was measured in a system consisting of Chang human liver cells, rabbit anti-Chang antiserum, and Triosil-Ficoll purified human lymphocytes. It was concluded that one K cell probably inactivates or kills one target cell, and that the number of active K cells is similar in the peripheral blood of normal and rheumatoid subjects and is about 0-5%.
D000906:Antibodies; D001172:Arthritis, Rheumatoid / Q000276:immunology*; D002460:Cell Line; D002470:Cell Survival; D003601:Cytotoxicity Tests, Immunologic / Q000379:methods; D006801:Humans; D008214:Lymphocytes / Q000276:immunology*
D000906:Antibodies