The induction of immune tolerance in delayed contact sensitivity by the use of chemically related substances of low immunogenicity.
Immune tolerance in delayed contact sensitivity to pentadecylcatechol can be induced by a series of derivatives substituted in the 6 position of the ring. Some of these derivatives have the property of being very poor sensitizers and having very low dermal toxicity. Thus, sensitization and tolerance have different biologic mechanisms and are associated with different properties of these chemicals.
D000818:Animals; D002396:Catechols / Q000008:administration & dosage / Q000276:immunology*; D003877:Dermatitis, Contact / Q000276:immunology*; D004305:Dose-Response Relationship, Drug; D006168:Guinea Pigs; D006968:Hypersensitivity, Delayed / Q000276:immunology*; D007108:Immune Tolerance / Q000187:drug effects; D008297:Male; D012867:Skin / Q000276:immunology
D002396:Catechols