Studies on sodium ion retention and antidiuretic effects after administration of L-tryptophan to rats.
Under certain conditions the i.p. injection of L-tryptophan leads to a reduction of elimination of Na+. At the same time, the fractional Na+ -reabsorption increases. No increase in the absolute tubular sodium transport rate was observed since the significantly reduced plasma-sodium concentration leads to a decreased sodium load. The most probable cause of a decreased plasma-sodium concentration seems to be a retention of sodium-free water under the chosen conditions of infusion. The water retention is compatible with the antidiuretic effect of 5-hydroxytryptamine.
D000818:Animals; D004231:Diuresis / Q000187:drug effects*; D005919:Glomerular Filtration Rate; D008297:Male; D009994:Osmolar Concentration; D010649:Phenylalanine / Q000494:pharmacology; D051381:Rats; D012964:Sodium / Q000097:blood / Q000378:metabolism*; D013237:Stereoisomerism; D013997:Time Factors; D014364:Tryptophan / Q000031:analogs & derivatives / Q000494:pharmacology*; D014882:Water-Electrolyte Balance / Q000187:drug effects
D010649:Phenylalanine; D014364:Tryptophan; D012964:Sodium