Effect of propylene glycol and ethanol on 3H-noradrenaline efflux from an isolated blood vessel.
Propylene glycol (14 mM), but not ethanol (17 mM), enhanced the late phase of passive 3H-efflux from rabbit isolated aortic rings preloaded with 3H-(-)-noradrenaline. We conclude that, with regard to 3H-noradrenaline release studies, propylene glycol is unsuitable for aiding the dissolution of e.g. corticosterone in physiological salt solution, while ethanol can be used for this purpose.
D000818:Animals; D001011:Aorta / Q000187:drug effects* / Q000378:metabolism; D001692:Biological Transport / Q000187:drug effects; D000431:Ethanol / Q000494:pharmacology*; D066298:In Vitro Techniques; D009638:Norepinephrine / Q000378:metabolism*; D011409:Propylene Glycols / Q000494:pharmacology*; D011817:Rabbits; D012997:Solvents
D011409:Propylene Glycols; D012997:Solvents; D000431:Ethanol; D009638:Norepinephrine