Radioimmunological determination of thromboxane release in cardiac anaphylaxis.
A sensitive and specific radioimmunoassay for thromboxane B2 were detected in perfusates of anaphylactic guinea pig hearts. Indomethacin decreased thromboxane B2 levels in the perfusates to below the detection limit of the radioimmunoassay and concomitantly delayed the onset of coronary vasoconstriction after antigenic challenge.
D000707:Anaphylaxis / Q000378:metabolism*; D000818:Animals; D003326:Coronary Circulation / Q000187:drug effects; D006168:Guinea Pigs; D006880:Hydroxy Acids / Q000378:metabolism*; D007213:Indomethacin / Q000494:pharmacology; D009206:Myocardium / Q000378:metabolism*; D011460:Prostaglandins F / Q000378:metabolism; D011714:Pyrans / Q000378:metabolism; D011863:Radioimmunoassay; D013997:Time Factors
D006880:Hydroxy Acids; D011460:Prostaglandins F; D011714:Pyrans; D007213:Indomethacin