title: Activity changes of chicken enzymes involved in glutamate and 2-oxoglutarate metabolism at the time of hatching.
abstract: At the time of hatching, activities of both KDH and succinate thiokinase increased in heart, while in liver only an enhanced activity of KDH was observed. Glutamate injected into egg exerted a stimulatory effect on KDH activity in chicken embryos but not in newborn chickens. There seems to be an age-dependent response of ASAT and GDH to stimulating effectors. In chicken embryos, 2-oxoglutarate induced GDH activity and in newly hatched chickens, ASAT activity. Concomitantly, liver protein content increased also. Administration of glutamate, however, was not followed by a significant activity increase of ASAT or GDH. Thus, the stimulation of ASAT and GDH activities seems to be favoured when they support glutamate formation out of 2-oxoglutarate.
mesh_terms: D000375:Aging; D000818:Animals; D000831:Animals, Newborn; D001219:Aspartate Aminotransferases / Q000378:metabolism; D002642:Chick Embryo; D002645:Chickens; D005969:Glutamate Dehydrogenase / Q000378:metabolism; D005971:Glutamates / Q000378:metabolism* / Q000494:pharmacology; D006321:Heart / Q000187:drug effects; D007656:Ketoglutaric Acids / Q000378:metabolism* / Q000494:pharmacology; D008099:Liver / Q000187:drug effects / Q000254:growth & development / Q000378:metabolism*; D009206:Myocardium / Q000378:metabolism*; D013389:Succinate-CoA Ligases / Q000378:metabolism
chemical_list: D005971:Glutamates; D007656:Ketoglutaric Acids; D005969:Glutamate Dehydrogenase; D001219:Aspartate Aminotransferases; D013389:Succinate-CoA Ligases