title: Metal carcinogenesis: a study of the carcinogenic activity of solid metal alloys in rats.
abstract: The carcinogenic activity of seven metallic alloys was studied by implanting solid rods of each alloy in the gluteal muscles of Sprague-Dawley rats which were killed after twenty-four months. When the number of tumors in these rats was compared with the numbers in rats not operated on, in rats which had a sham operation, and in rats implanted with Silastic rods, no statistically significant differences in the incidences of the tumors in the several groups were found.
mesh_terms: D000497:Alloys / Q000009:adverse effects*; D000818:Animals; D002081:Buttocks; D005260:Female; D005593:Fracture Fixation, Internal / Q000009:adverse effects*; D007595:Joint Prosthesis / Q000009:adverse effects*; D008297:Male; D008325:Mammary Neoplasms, Experimental / Q000139:chemically induced; D009196:Myeloproliferative Disorders / Q000139:chemically induced; D009362:Neoplasm Metastasis; D009374:Neoplasms, Experimental / Q000139:chemically induced*; D051381:Rats; D012004:Rectal Neoplasms / Q000139:chemically induced
chemical_list: D000497:Alloys