Inhibition of thymidylate synthetase of Walker carcinoma by chlorambucil. A possible mechanism of action.
D000818:Animals; D002279:Carcinoma 256, Walker / Q000188:drug therapy / Q000201:enzymology* / Q000648:ultrastructure; D002474:Cell-Free System; D002699:Chlorambucil / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D004334:Drug Administration Schedule; D004351:Drug Resistance; D066298:In Vitro Techniques; D008297:Male; D008780:Methyltransferases / Q000037:antagonists & inhibitors*; D009368:Neoplasm Transplantation; D051381:Rats; D013762:Tetrahydrofolate Dehydrogenase / Q000378:metabolism; D013937:Thymidine Kinase / Q000378:metabolism; D013940:Thymidylate Synthase / Q000037:antagonists & inhibitors*; D013997:Time Factors; D014184:Transplantation, Homologous
D002699:Chlorambucil; D013762:Tetrahydrofolate Dehydrogenase; D008780:Methyltransferases; D013940:Thymidylate Synthase; D013937:Thymidine Kinase