Tumor induction in intact and regenerating liver of adult rats by a single treatment with methylazoxymethanol acetate.
Methylazoxymethanol (MAM) acetate was given once i.p. to intact adult rats and to rats at 24 h after partial hepatectomy. In each group, tumors developed as early as 10 months. The incidence of neoplastic nodules and of hepatocellular carcinomas in the carcinogen-treated intact adult rats was approximately 70% and, in the rats treated after partial hepatectomy, it was approximately 80%. The data suggest that both dividing and resting liver cells are sensitive to the tumor-initiating effects of methylazoxymethanol acetate.
D000818:Animals; D001391:Azo Compounds / Q000494:pharmacology*; D008099:Liver / Q000187:drug effects; D008113:Liver Neoplasms / Q000139:chemically induced*; D008115:Liver Regeneration / Q000187:drug effects*; D008297:Male; D008746:Methylazoxymethanol Acetate / Q000494:pharmacology*; D009374:Neoplasms, Experimental / Q000188:drug therapy; D051381:Rats
D001391:Azo Compounds; D008746:Methylazoxymethanol Acetate