The generation and identification of the hemolysin of Trypanosoma congolense.
The hemolytic activity of Trypanosoma congolense appears to be due to the presence of free fatty acids generated by the action of phospholipase A on endogenous phosphatidyl choline. Some lysolecithin also contributes to the lytic activity. Trypanosoma lewisi, being devoid of phospholipase A, does not generate free fatty acids and is therefore non-hemolytic.
D000818:Animals; D004912:Erythrocytes; D005230:Fatty Acids, Nonesterified / Q000032:analysis; D006460:Hemolysin Proteins / Q000302:isolation & purification; D006461:Hemolysis; D008049:Lipase / Q000378:metabolism; D008244:Lysophosphatidylcholines; D010740:Phospholipases / Q000378:metabolism; D012756:Sheep; D014345:Trypanosoma
D005230:Fatty Acids, Nonesterified; D006460:Hemolysin Proteins; D008244:Lysophosphatidylcholines; D010740:Phospholipases; D008049:Lipase