title: [Age and changes in the levels of biogenic amines in the brains of rats].
abstract: No significant change occurs in the total cerebral level of norepinephrine, dopamine, and histamine in rats of 1--36 months age, whereas the serotonin (5-HT) level is increasing. During the maturation period the hypothalamic levels of catecholamines and histamine are increasing. Between 2--36 months of life the hypothalamic norepinephrine level decreases while 5-HT, 5-HIAA, and histamine do not change. Role of the age-related changes of brain biogenic amines in disturbances of neuroendocrine feedback mechanisms is discussed.
mesh_terms: D000367:Age Factors; D000375:Aging; D000818:Animals; D001679:Biogenic Amines / Q000032:analysis*; D001923:Brain Chemistry / Q000187:drug effects; D001933:Brain Stem / Q000032:analysis; D004298:Dopamine / Q000032:analysis; D006632:Histamine / Q000032:analysis; D006897:Hydroxyindoleacetic Acid / Q000032:analysis; D007980:Levodopa / Q000494:pharmacology; D008297:Male; D009638:Norepinephrine / Q000032:analysis; D051381:Rats; D012701:Serotonin / Q000032:analysis; D012741:Sexual Maturation
chemical_list: D001679:Biogenic Amines; D012701:Serotonin; D007980:Levodopa; D006897:Hydroxyindoleacetic Acid; D006632:Histamine; D004298:Dopamine; D009638:Norepinephrine
vernacular_title: Vozrastnye izmeneniia urovnia biogennykh aminov v golovnom mozge krys