Determination of protein synthesis elongation factor activity in liver biopsy specimens from normal and cirrhotic rats.
In liver biopsy specimens (between 8.5 and 22 mg wet weight) obtained from normal and thioacetamide-induced cirrhotic rat liver the polypeptide-chain-elongationpromoting activity (elongation factors 1 and 2) was determined. In liver cirrhosis the activity is reduced by about 50%.
D000818:Animals; D001706:Biopsy; D004247:DNA / Q000032:analysis; D008099:Liver / Q000378:metabolism* / Q000473:pathology; D008103:Liver Cirrhosis / Q000201:enzymology / Q000378:metabolism*; D008297:Male; D010445:Peptide Elongation Factors / Q000032:analysis; D010649:Phenylalanine / Q000096:biosynthesis; D014176:Protein Biosynthesis; D051381:Rats; D011919:Rats, Inbred Strains
D010445:Peptide Elongation Factors; D010649:Phenylalanine; D004247:DNA