Elements of a DNA-polypeptide recognition code: electrostatic potential around the double helix, and a stereospecific model for purine recognition.
A model for stereospecific complex between a polynucleotide double helix and a twisted beta-ribbon type polypeptide is described. The beta ribbon lies in the major groove with alternate side chains pointing toward the interior of the groove. The base-amino acid complementarities are: Arg, G and Asn or Gln, A. It is shown that this complex can: (a) distinguish between G and A in homopolar sequences; (b) the complex is stabilized by approx. 6 Kcal/mole per hydrogen bond per base pair; (c) the required backbone conformation is in the permitted range of Ramachandran plots.
D001120:Arginine; D001665:Binding Sites; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D003201:Computers; D004247:DNA; D005973:Glutamine; D006860:Hydrogen Bonding; D008961:Models, Structural; D009690:Nucleic Acid Conformation; D009842:Oligopeptides; D010455:Peptides; D011487:Protein Conformation; D011687:Purines
D009842:Oligopeptides; D010455:Peptides; D011687:Purines; D005973:Glutamine; D004247:DNA; D001120:Arginine