Effect of vehicles on the spermicidal potency of certain drugs.
Different spermicidal drugs were formulated into ointments, creams, pastes and jellies and tested for their spermicidal potency on human sperms adopting a modified in vitro technique. Of the formulae tested, those incorporated in Carbopol 934 of polyethylene glycol base exhibited the most prevailing spermicidal activity.
D005260:Female; D006801:Humans; D008297:Male; D010592:Pharmaceutic Aids / Q000494:pharmacology*; D011092:Polyethylene Glycols / Q000494:pharmacology; D012995:Solubility; D013094:Spermatozoa / Q000187:drug effects*; D014622:Vaginal Creams, Foams, and Jellies
D010592:Pharmaceutic Aids; D014622:Vaginal Creams, Foams, and Jellies; D011092:Polyethylene Glycols