(D)-penicillamine treatment in systemic sclerosis (scleroderma). Effect on nutritional capillary circulation.
Four patients with systemic sclerosis (scleroderma) were treated with (D)-penicillamine (1.2-1.8 g/d) for 18-60 months. All patients improved. Vital capillary microscopy demonstrated that the number of visible skin capillaries increased during therapy, thus indicating a more efficient nutritional circulation.
D000328:Adult; D000368:Aged; D002196:Capillaries / Q000187:drug effects; D002199:Capillary Permeability / Q000187:drug effects; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010396:Penicillamine / Q000494:pharmacology / Q000627:therapeutic use*; D012595:Scleroderma, Systemic / Q000188:drug therapy*
D010396:Penicillamine