Immunoelectron microscopy of surface immunoglobulins in pseudolymphoma of the lung. Report of a case.
A case of pseudolymphoma of the lung was studied by light, electron, and immunoelectron microscopy. The tumor consisted predominantly of small lymphoid cells with a few germinal centers. Both light and dark cells were found by electron microscopy. While the dark cells contained abundant free ribosomes, lysosome-like electron dense bodies were more prominent in the light cells. The proportion of surface staining positive pseudolymphoma cells for IgC, IgM, and IgA was high (each about 80%) compared with control spleen cell suspensions by immunoelectron microscopy. But the serum levels of IgG, IgM, and IgA were normal. It is discussed that the polyclonal presence of surface immunoglobulins does not necessarily support the benign nature of the disease.
D000328:Adult; D002462:Cell Membrane / Q000276:immunology / Q000648:ultrastructure*; D006801:Humans; D007070:Immunoglobulin A; D007074:Immunoglobulin G; D007075:Immunoglobulin M; D007136:Immunoglobulins; D008175:Lung Neoplasms / Q000276:immunology / Q000648:ultrastructure*; D008223:Lymphoma / Q000276:immunology / Q000648:ultrastructure*; D008297:Male; D013499:Surface Properties
D007070:Immunoglobulin A; D007074:Immunoglobulin G; D007075:Immunoglobulin M; D007136:Immunoglobulins