NaCl and LiCl efficacy in the induction of aversion for quinine and saccharin solutions immediately following injection.
Rats 24-hr water deprived were injected IP with a fixed amount (10 ml/kg) of solution of various concentrations of LiCl and NaCl in dosage ranges which in previous experiments either increased or had no effect on water intake. Intake of 0.01% QHCl decreased with increasing concentrations of both NaCl and LiCl. On a molar basis, LiCl was more effeictive. LiCl also produced an aversion to a palatable solution, 0.1% sodium saccharin; however, NaCl produced no aversion over the dosage range which can be tolerated by the animals.
D000818:Animals; D001362:Avoidance Learning / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D005260:Female; D008094:Lithium / Q000494:pharmacology*; D009043:Motor Activity / Q000187:drug effects; D011803:Quinine / Q000494:pharmacology*; D051381:Rats; D012439:Saccharin / Q000494:pharmacology*; D012965:Sodium Chloride / Q000494:pharmacology*; D013997:Time Factors; D014868:Water Deprivation
D012965:Sodium Chloride; D008094:Lithium; D011803:Quinine; D012439:Saccharin