Effects of mitomycin C in postnatal tooth development in mice with special reference to neural crest cells.
Neural crest cells in the pre- and postnatal development of mice showed a specific sensitivity to mitomycin C. In mice injected with mitomycin C 24-48 h after birth and surviving up to the 9th day, a free or attached denticle in the pulp and a fibroma or excessive cell proliferation in the dental follicle or the periodontal ligament were seen; further, a dentinoma developed.
D000818:Animals; D002470:Cell Survival / Q000187:drug effects; D005350:Fibroma / Q000473:pathology; D051379:Mice; D008937:Mitomycins / Q000494:pharmacology*; D009474:Neurons / Q000187:drug effects; D009808:Odontogenic Tumors / Q000473:pathology; D014070:Tooth / Q000187:drug effects* / Q000254:growth & development / Q000473:pathology
D008937:Mitomycins