[Effect of lithium on the serotonin and kynurenine paths of tryptophan metabolism].
Lithium carbonate in dosages from 50--100 mg/kg leads to an increase of tryptophanepyrrolase activity in the liver of rats from 50--80%, 5 hours following a single-time intraperitoneal administration and does not exert any influence after 1,3 and 20 hours. The same dosages (50 and 100 mg/kg) of lithium lead to an increase of II-hydroxycorticosteroids in in the blood plasma of rats to 2.5 times and could be prevented by a preliminary administration of dexametasone. A chronic administration of lithium (50 mg/kg) during 10 days did not exert any influence on the triptophanepyrrolase activity and the level of 11-hydroxycorticosteroids in the blood plasma of rats. These data permit of assume that an increase of tryptophanepyrrolase activity by lithium is moderated by an increase of II-hydroxycorticosteroids in the blood.
D015062:11-Hydroxycorticosteroids / Q000097:blood*; D000315:Adrenalectomy; D000818:Animals; D008094:Lithium / Q000494:pharmacology*; D008099:Liver / Q000201:enzymology*; D051381:Rats; D013997:Time Factors; D014366:Tryptophan Oxygenase / Q000378:metabolism*
D015062:11-Hydroxycorticosteroids; D008094:Lithium; D014366:Tryptophan Oxygenase
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