title: [Dependence of age and cell-mediated immunity by newborn and adult children (author's transl)].
abstract: In a course study the parameters of cellular immunoreaction were elaborated in more than 100 childrens by means of the lymphocyte transformations test and the macrophage migration inhibitiontest. Homologous and autologous lymphocytes were used as antigens. In addition tests were performed with PHA-M, PPD and bacterial antigens. In the center of the research is the problem of the functional structure of the stem-cell pool and the regulatory mechanisms of the systems as a whole. This basis biological property is the prerequisite for many reactions of the cellular immune system. Therefore, lymphocyte transformation tests appear to be a valuable diagnostic approach to define primary and secondary immuno deficiency associated with different diseases. The various results in the lymphocyte transformation test are presented in relation to age, diagnosis and treatment.
mesh_terms: D000293:Adolescent; D000328:Adult; D000375:Aging; D002648:Child; D002675:Child, Preschool; D006801:Humans; D006967:Hypersensitivity / Q000276:immunology; D007111:Immunity, Cellular; D007223:Infant; D007231:Infant, Newborn; D037102:Lectins; D008213:Lymphocyte Activation; D014373:Tuberculin; D014777:Virus Diseases / Q000276:immunology
chemical_list: D037102:Lectins; D014373:Tuberculin
vernacular_title: Untersuchungen zur Entwicklung zellgebundener Immunreaktionen vom Neugeborenen- bis zum Adoleszentenalter.