Separation of alkyl derivatives of uracil by solvophobic adsorption chromatography on spheron.
Derivatives of such related substances as cytosine, uracil, thymine, 6-methyl-uracil, 5-ethyluracil, 5-propyluracil, 5-isopropyluracil, 5-cyclopropyluracil, 5-allyluracil, 5,6-trimethyleneuracil, 6-cyclopropyluracil, 5-cyclobutyluracil and 5-tert-butyluracil have been separated on a column of Spheron P-300. Retention on the column was found to depend on the size of the non-polar part of the molecule. The chromatographic behaviour is analyzed according to the theory of solvophobic chromatography.
D055598:Chemical Phenomena; D002621:Chemistry; D002853:Chromatography, Liquid / Q000295:instrumentation / Q000379:methods; D011743:Pyrimidines / Q000302:isolation & purification; D012995:Solubility; D013696:Temperature; D014498:Uracil / Q000031:analogs & derivatives* / Q000302:isolation & purification
D011743:Pyrimidines; D014498:Uracil