title: In vitro effects of Rubella virus, strain RA 27/3, on human lymphocytes. II. Specific antigen stimulation in relation to Rubella haemagglutination inhibition antibodies.
abstract: Investigation has been made of the specific in vitro stimulation of human lymphocytes by live or inactivated rubella virus of the strain RA 27/3. The thymidine incorporation of lymphocytes from blood donors with different serological immunity against rubella was measured following incubation with the viral antigens. UV-inactivated rubella virus caused a moderate degree of stimulation of lymphocytes from seropositive individuals. On the other hand, live rubella virus stimulated lymphocytes from donors with low titres of anti-rubella HI-antibodies but not lymphocytes from donors with high antibody titres. Possible explanations for this discrepancy are discussed.
mesh_terms: D000328:Adult; D000914:Antibodies, Viral; D000956:Antigens, Viral; D005260:Female; D006385:Hemagglutination Inhibition Tests; D006801:Humans; D008213:Lymphocyte Activation; D008297:Male; D008875:Middle Aged; D012412:Rubella virus / Q000276:immunology* / Q000528:radiation effects; D014466:Ultraviolet Rays
chemical_list: D000914:Antibodies, Viral; D000956:Antigens, Viral