Comparison of six procedures for the simultaneous determination of antiepileptic drugs.
A comparison of six gas-chromatographic procedures for the simultaneous analysis of antiepileptic drugs was made. Methylation with 0.2M trimethylanilinium hydroxide was superior to other derivatizing procedures evaluated. The methylated derivatives of phenobarbital, carba-mazepine, primidone, and diphenyl-hydantoin were separated on the chromatogram, and the peaks were sharp and symmetrical. The four drugs gave linear curves to twice their toxic levels.
D000927:Anticonvulsants / Q000097:blood*; D002220:Carbamazepine / Q000097:blood; D002849:Chromatography, Gas / Q000379:methods*; D004827:Epilepsy / Q000097:blood*; D006801:Humans; D010634:Phenobarbital / Q000097:blood; D010672:Phenytoin / Q000097:blood; D011324:Primidone / Q000097:blood
D000927:Anticonvulsants; D011324:Primidone; D002220:Carbamazepine; D010672:Phenytoin; D010634:Phenobarbital