Investigations on prostatic adenocarcinomas in rats.
Metastatic prostate adenocarcinomas, derived from aging germfree Wistar rats, have been propagated in rats and in tissue culture. A protocol has been developed and demonstrated for assay of treatments which retard or which accelerate the rate and extent of tumor growth and of metastasis in tumor-bearing rats. The pattern of spread has been retarded by cyclophosphamide, aspirin, indomethacin, and Corynebacterium parvum. The spread pattern has been accelerated by oral administrations of sodium barbiturate.
D000230:Adenocarcinoma / Q000628:therapy*; D000777:Anesthetics / Q000494:pharmacology; D000818:Animals; D001241:Aspirin / Q000494:pharmacology; D002460:Cell Line; D005260:Female; D007167:Immunotherapy; D007213:Indomethacin / Q000494:pharmacology; D008175:Lung Neoplasms / Q000628:therapy; D008297:Male; D009362:Neoplasm Metastasis / Q000628:therapy; D009368:Neoplasm Transplantation; D009374:Neoplasms, Experimental / Q000628:therapy; D011425:Propionibacterium acnes / Q000276:immunology; D011471:Prostatic Neoplasms / Q000628:therapy*; D051381:Rats; D014184:Transplantation, Homologous
D000777:Anesthetics; D001241:Aspirin; D007213:Indomethacin