title: Effect of intermittent phototherapy on bilirubin dynamics in Gunn rats.
abstract: To determine whether continuous phototherapy is necessary to control neonatal jaundice, groups of jaundiced (Gunn) rats were exposed to four blue light regimens: continuous light, 30 min light/30 min dark, 6 min light/6 min dark, and 6 min light/18 min dark. An exponential decrease in serum bilirubin concentration (SBC) was found with all regimens. A logarithmic dose response curve was obtained with a 50% light dose exhibiting 75% efficacy, and a 25% light dose exhibiting 59% efficacy compared to continuous phototherapy. The time constants of the decrease in serum bilirubin concentration also varied logarithmically with doses with continuous therapy having a time constant of 1.4 days, and 6 min light/18 min dark therapy having a time constant of 3 days.
mesh_terms: D000818:Animals; D001663:Bilirubin / Q000097:blood / Q000528:radiation effects*; D005260:Female; D007700:Kinetics; D008297:Male; D010789:Phototherapy; D051381:Rats; D012737:Sex Factors; D013223:Statistics as Topic; D013997:Time Factors
chemical_list: D001663:Bilirubin