[Effect of apressin on the mechanism regulating vascular tone].
Acute experiments with anesthetized and decerebrate cats brought evidence that in a dose of 1 mg/kg apressin first increases by 50 per cent the centrogenically-produced pressor vascular reactions and then (30-60 min thereafter) suppresses pressor responses. Apressin (in a dose of 3-5 mg/kg) appreciably weakens the intensity of the pressor vascular reactions and increases the efferent outflow in the renal nerve. In doses of 1-10 mg/kg it does not affect the transmission of excitation in the superior cervical sympathic ganglion and in the solar plexus nodes. In tests with the crossed circulation apressin in doses of 1 and 5 mg/kg produces a marked depression of vascular reactions and a drop of the perfusion pressure in the vessels of the hind extremity perfused with the autoblood and a rising intensity of these reactions along with a greater resistance of the hind extremity vessels, perfused with the donor's blood.
D000818:Animals; D001794:Blood Pressure; D002415:Cats; D002447:Celiac Plexus / Q000187:drug effects; D003655:Decerebrate State; D005725:Ganglia, Autonomic / Q000187:drug effects; D006614:Hindlimb / Q000098:blood supply; D006830:Hydralazine / Q000494:pharmacology*; D014655:Vascular Resistance / Q000187:drug effects; D014666:Vasomotor System / Q000187:drug effects*
D006830:Hydralazine
Deĭstvie apressina na mekhanizmy reguliatsii sosudistogo tonusa.