Liver function in leprosy.
Thirty eight patients of leprosy were classified on the basis of clinical and biopsy findings into 10 lepromatous (all reactional), 20 tuberculoid (7 in reaction) and 8 dimorphic (5 in reaction). The liver function tests--serum proteins, albumin/globulin ratio, fractions in paper electrophoresis, serum glutamic pyruvic transaminase (SGPT) and thymol turbidity tests--and the serum cholesterol was estimated in each patient. The abnormalities were a reversal of the albumin/globulin ratio in all the three groups and an increase in beta/globulin fraction in the lepromatous group, but total proteins were within normal limits. The thymol turbidity test showed moderately elevated levels in all three groups. SGPT was slightly raised in a few cases. Only a single patient with tuberculoid leprosy showed serum cholesterol to be over 250 mg per 100 ml.
D000410:Alanine Transaminase / Q000097:blood; D001798:Blood Proteins / Q000378:metabolism; D002784:Cholesterol / Q000097:blood; D006801:Humans; D007918:Leprosy / Q000097:blood / Q000150:complications / Q000503:physiopathology*; D008099:Liver / Q000503:physiopathology*; D008107:Liver Diseases / Q000097:blood / Q000175:diagnosis / Q000209:etiology; D008111:Liver Function Tests; D012709:Serum Albumin / Q000378:metabolism; D012712:Serum Globulins / Q000378:metabolism; D013943:Thymol
D001798:Blood Proteins; D012709:Serum Albumin; D012712:Serum Globulins; D013943:Thymol; D002784:Cholesterol; D000410:Alanine Transaminase