Effect of mianserine on brain serotonin turnover in mice.
One hr after mianserine administration brain 5-HT concentration was reduced, the greatest decrease was observed with 2.5 mg/kg dose. This reduction lasted for 1 hr. Brain 5-HT turnover was increased by all doses of mianserine used. The increase in brain 5-HT turnover after a single injection lasted for 8 hr. This increase may be related to inhibition of central 5-HT receptors.
D000818:Animals; D001921:Brain / Q000187:drug effects / Q000378:metabolism*; D003984:Dibenzazepines / Q000494:pharmacology*; D008297:Male; D008803:Mianserin / Q000494:pharmacology*; D051379:Mice; D010293:Pargyline; D012701:Serotonin / Q000378:metabolism*; D013997:Time Factors
D003984:Dibenzazepines; D008803:Mianserin; D012701:Serotonin; D010293:Pargyline