[Kinetics of sodium thiosulfate-35S fixation and effect of some sulfur compounds on iodine-131 fixation in ray thyroid gland].
In order to invalidate or confirm the affirmation that non antithyroid sulphide molecules alter the measure of the thyroid fixation rate of iodine 131 we undertook on the rat: on one hand a kinetic study of thyroid fixation of sodium thiosulfate labelled with sulphur 35, which showed a very low captation not exceeding 0,01% of injected radioactivity; on the other hand the study of the effects of some sulphide molecules on thyroid fixation of iodine 131 in the rat: sodium thiosulfate, association of sodium thiosulfate + metalloidal sulphur + methionine, carbutamide and dimethylsulfoxyde in various kinds of dose administration and periods. None of the products used in our work conditions produced a significant decrease of the fixation rate of iodine 131. In three different experimental protocols (sulfur association and dimethylsulfoxide), we showed a significant light increase of the fixation rate.
D000818:Animals; D002271:Carbutamide / Q000494:pharmacology; D004121:Dimethyl Sulfoxide / Q000494:pharmacology; D005260:Female; D007457:Iodine Radioisotopes / Q000378:metabolism*; D007700:Kinetics; D008297:Male; D008715:Methionine / Q000494:pharmacology; D051381:Rats; D013455:Sulfur / Q000494:pharmacology*; D013885:Thiosulfates / Q000378:metabolism* / Q000494:pharmacology; D013961:Thyroid Gland / Q000187:drug effects / Q000378:metabolism*
D007457:Iodine Radioisotopes; D013885:Thiosulfates; D013455:Sulfur; D008715:Methionine; D002271:Carbutamide; D004121:Dimethyl Sulfoxide
Cinétique de fixation thyroïdienne du thiosulfate de sodium-35 S et effets de quelques molécules soufrées sur la fixation thyroïdienne de l'iode 131 chez le rat.