[Influence of whole-body X-ray irradiation and 2, 4, 6-triethyleneimino- 1, 3, 5-triazine on the hypnotic effect of hexobarbital in mice (author's transl)].
The hypnotic effect of hexobarbital, measured in male NMRI-mice, was reduced during the first 24 hours after a unique or fractionated whole-body X-ray irradiation with 700 and 1400 R resp. 70 to 280 R and twelve hours after a unique intravenous injection of 16,0 mg tretamine per kilogram of body weight. Immediately after a unique injection of a high dose of tretamine and 24 hours after the last of four applications of 0,25 to 2,0 mg/kg which were repeated each after one day, the sleeping time after hexobarbital was prolonged. 24 hours after fractionated injection of tretamine (0,5 mg/kg each time), the concentration of hexobarbital in the brain showed a significant increase compared with the control animals. These results show that the decreased effect of hexobarbital in the early post-irradiation phase is based on pharmacodynamic processes while the increase of the effect produced by continued administration of tretamine can be explained by pharmaco-cinetic reasons.
D000818:Animals; D001923:Brain Chemistry; D004347:Drug Interactions; D006591:Hexobarbital / Q000032:analysis / Q000494:pharmacology*; D006993:Hypnotics and Sedatives; D008297:Male; D051379:Mice; D011829:Radiation Dosage; D012890:Sleep; D013997:Time Factors; D014227:Triazines / Q000494:pharmacology*; D014965:X-Rays
D006993:Hypnotics and Sedatives; D014227:Triazines; D006591:Hexobarbital
Zum Einfluss von Ganzkörper-Röntgenbestrahlung und 2, 4, 6-triäthylenimino-1, 3, 5-triazin auf die hypnotische Wirkung von Hexobarbital bei Mäusen.