Genes and geography.
The author discusses a number of genetically determined diseases, such as hemoglobinopathies, acute intermittent porphyria, familial Mediterranean fever and so-called acquired hypogammaglobulinemia from the geographical point of view. Possible factors explaining localized increases in incidence are discussed. The importance of isolates for the development of such foci is stressed.
D000361:Agammaglobulinemia / Q000453:epidemiology / Q000235:genetics; D000686:Amyloidosis / Q000453:epidemiology; D005260:Female; D005387:Finland; D006402:Hematologic Diseases / Q000453:epidemiology* / Q000235:genetics; D006453:Hemoglobinopathies / Q000453:epidemiology / Q000235:genetics; D006467:Hemophilia A / Q000235:genetics; D006801:Humans; D008297:Male; D008661:Metabolism, Inborn Errors / Q000453:epidemiology / Q000235:genetics; D009154:Mutation; D011164:Porphyrias / Q000453:epidemiology; D013019:South Africa; D013548:Sweden