Pharmacodynamics and pharmacokinetics of psycholeptic drugs in the course of radiation disease. Effect of premedication with metanabol on dynamics and kinetics of nitrazepam.
The effect of metanabol given to rats before irradiation (600 R) on exploring motility and cataleptic action of nitrazepam was investigated. The level of nitrazepam in the blood plasma and urine was determine. Most evident radioprotective effect of metanabol was found on 3rd day after irradiation. The drug inhibited the inhibited the increased response of the rats to the anticonvulsive action of nitrazepam and prevented the pharmacokinetic disturbances appearing in the course of radiation disease.
D000818:Animals; D007700:Kinetics; D008297:Male; D008696:Methandrostenolone / Q000494:pharmacology*; D009567:Nitrazepam / Q000037:antagonists & inhibitors / Q000378:metabolism / Q000494:pharmacology*; D011833:Radiation Injuries, Experimental / Q000378:metabolism*; D011837:Radiation-Protective Agents / Q000494:pharmacology*; D051381:Rats
D011837:Radiation-Protective Agents; D009567:Nitrazepam; D008696:Methandrostenolone