title: Clinical significance of the isomorphic pattern of the isoenzymes of serum lactate dehydrogenase.
abstract: Five hundred patients with the isomorphic pattern of the isoenzymes of serum lactate dehydrogenase (LDH) were surveyed. The isomorphic pattern of LDH isoenzymes is defined as a significant increase of total LDH with normal or low percentage of individual fractions, but with the LDH1:2 ratio less than unity. Diagnoses were, in descending order of frequency, cardiorespiratory diseases, malignancy, fracture, diseases of the central nervous system, infection/inflammation, hepatic cirrhosis and/or alcoholism, trauma without fracture, infectious mononucleosis, hypothyroidism, uremia, necrosis, pseudomononucleosis, viremia and intestinal obstruction. Incidence of increased serum activity in individuals without evidence of disease or drug explanation was 3 percent. Low PaO2 was observed in 88 percent of the 67 patients in whom it was measured.
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000437:Alcoholism / Q000201:enzymology; D001927:Brain Diseases / Q000201:enzymology; D005189:False Positive Reactions; D005260:Female; D006331:Heart Diseases / Q000201:enzymology; D006801:Humans; D007037:Hypothyroidism / Q000201:enzymology; D007244:Infectious Mononucleosis / Q000201:enzymology; D007527:Isoenzymes; D007536:Isomerism; D007770:L-Lactate Dehydrogenase / Q000097:blood*; D008103:Liver Cirrhosis / Q000201:enzymology; D008173:Lung Diseases, Obstructive / Q000201:enzymology; D008297:Male; D008875:Middle Aged; D009336:Necrosis / Q000201:enzymology; D009369:Neoplasms / Q000201:enzymology; D011086:Polycythemia / Q000201:enzymology; D014511:Uremia / Q000201:enzymology; D014947:Wounds and Injuries / Q000201:enzymology
chemical_list: D007527:Isoenzymes; D007770:L-Lactate Dehydrogenase