title: Effect of melatonin implants on gonadal weights and pineal gland fine structure of the golden hamster.
abstract: Weekly subcutaneous implants of melatonin in a beeswax pellet prevented the testicular regression which normally occurs in hamsters exposed to short photoperiod for 8 weeks. Normal (14L:10D) hamster testes were indistinguishable from the testes of melatonin-treated (1L:23D) hamsters. The exogenous melatonin had varied effects on the fine structure of the golden hamster pineal gland. Pineal ocyte nuclear characteristics of melatonin-treated hamsters (smaller average diameter, less polymorphism, and more heterochromatin) as well as apparent reductions in the amounts of hypertrophic SER and lipid moieties seemed to indicate that melatonin caused inhibition of pineal gland activity, and in this respect counteracted the effects of short photoperiod. However, an apparent increase in the number of large mitochondria, membrane whorls and dense-cored secretory vesicles in pinealocytes of melatonin-treated hamsters suggests enhanced pineal gland activity.
mesh_terms: D000818:Animals; D002467:Cell Nucleus / Q000187:drug effects; D006224:Cricetinae; D004721:Endoplasmic Reticulum / Q000187:drug effects; D008297:Male; D008550:Melatonin / Q000494:pharmacology*; D008566:Membranes / Q000187:drug effects; D008647:Mesocricetus; D008928:Mitochondria / Q000187:drug effects; D009929:Organ Size / Q000187:drug effects; D009940:Organoids / Q000187:drug effects; D010870:Pineal Gland / Q000187:drug effects* / Q000648:ultrastructure; D012669:Seminal Vesicles / Q000187:drug effects*; D013737:Testis / Q000187:drug effects*
chemical_list: D008550:Melatonin