[The nephrotoxic potential of cefalotin-aminoside antibiotic combinations (author's transl)].
The combined study of animal experimental findings and clinical trials indicates the minimal effect on renal function of a combination of Cefalotin with aminoglycosides. Nevertheless, whilst the published cases of renal insufficiency are often difficult to analyse with regard to the exclusive responsibility of antibiotic therapy, it seems that strict attention to dose and frequency of administration is essential when this combination is prescribed and that regular surveillance of renal function is necessary, above all with prolonged treatment. The renal toxicity of aminoglycosides more recent than Gentamicin has not yet been fully explored, the same applying to their use in association with Cefalotin.
D058186:Acute Kidney Injury / Q000139:chemically induced*; D000617:Aminoglycosides / Q000633:toxicity*; D000818:Animals; D002512:Cephalothin / Q000633:toxicity*; D004357:Drug Synergism; D004359:Drug Therapy, Combination; D005839:Gentamicins / Q000009:adverse effects; D006801:Humans; D014031:Tobramycin / Q000009:adverse effects
D000617:Aminoglycosides; D005839:Gentamicins; D002512:Cephalothin; D014031:Tobramycin
Le potentiel néphrotoxique de l'association antibiotique céfalotine-aminosides.