title: Further comments on novel schedule TLVs.
abstract: The general formula approach for the development of TLVs for novel work schedules represents a reasonable first attempt in dealing with this new industrial health problem. However, several additional factors should be considered in the derivation of novel work schedule TLVs. They include: 1. the individuals who are at increased risk with respect to the pollutant in question; 2. the possible influences of rotational changes and disrupted circadian rhythms on health status of workers adopting the proposed novel schedules; 3. the type of toxicologic response to be affected and the degree of safety margin built into the TLV; 4. the metabolic rate and fate of the substance in the individual.
mesh_terms: D002273:Carcinogens / Q000378:metabolism; D002940:Circadian Rhythm; D004781:Environmental Exposure; D006801:Humans; D008452:Maximum Allowable Concentration; D008670:Metals / Q000009:adverse effects / Q000378:metabolism; D009787:Occupational Medicine; D010559:Personnel Management; D010561:Personnel Staffing and Scheduling; D012306:Risk; D013997:Time Factors
chemical_list: D002273:Carcinogens; D008670:Metals