title: [Alteration of the natural humoral immunity in experimental diphtheritic infection induced by different doses of the agent].
abstract: The authors carried out a complex study of natural humoral immunity factors in rabbits experimentally infected with various doses of diphtheria bacillus (500, 200, 100, 50 and 1 million, 10 000 and 1000 microorganisms). Natural protection factors--the complement, properdin, and lysozyme proved to undergo similar dynamic changes with each infection dose. The extent and direction of the changes depended on the infection dose. No significant natural immunity changes were caused by a low dose. A dose of 10 000 microbes caused stimulation of properdin and lysozyme activity. Dose of 1, 5, and 50 million suppressed the activity of all the components, the most pronounced with the later dose. Changes occurring with the doses of 200 and 100 million microbes were phasic in character.
mesh_terms: D000818:Animals; D003165:Complement System Proteins; D004165:Diphtheria / Q000276:immunology* / Q000382:microbiology; D009113:Muramidase / Q000097:blood*; D011414:Properdin / Q000378:metabolism*; D011817:Rabbits; D013997:Time Factors
chemical_list: D011414:Properdin; D003165:Complement System Proteins; D009113:Muramidase
vernacular_title: Izmenenie faktorov estestvennogo gumoral'nogo immunitata pri éksperimental'noĭ difteriĭnoĭ infektsii, vyzvannoĭ raznymi dozami vozbuditelia.