title: Plasma and intracellular kinetics of lithium after oral administration of various lithium salts.
abstract: Five healthy volunteers were treated orally with lithium carbonate, sulphate, or chloride. There were no significant differences in area under time-concentration curves, half-lives, total body clearance or apparent distribution volumes between the various salts, either in plasma or in the RBC compartment. The carbonate salt did show a higher RBC/plasma distribution ratio than the other salts, which might possibly imply greater therapeutic effectiveness of this salt. Some considerations on the tolerability of various lithium salts are discussed.
mesh_terms: D000284:Administration, Oral; D000293:Adolescent; D000328:Adult; D001682:Biological Availability; D004912:Erythrocytes / Q000378:metabolism; D005110:Extracellular Space / Q000378:metabolism; D006207:Half-Life; D006801:Humans; D007408:Intestinal Absorption; D007424:Intracellular Fluid / Q000378:metabolism; D008094:Lithium / Q000097:blood / Q000378:metabolism*; D008297:Male
chemical_list: D008094:Lithium