title: Increase in titer of the naturally occurring human antibody to neuraminidase-treated lymphocytes after influenza.
abstract: Nine of 25 (36%) humans suffering from naturally acquired influenza A infection developed significant increases in the titer of a "naturally" occurring antibody to neuraminidase-treated human lymphocytes. Only two of 43 normal and noninfluenza respiratory infection controls showed titer changes of this antibody, p less than 0.001. The antibody was not directed at influenza virus C fixation, hemagglutination inhibition, or neuraminidase antigens. Three of 10 normals given a highly immunogenic, formalin-killed influenza A vaccine developed significant titer rises. These results suggest that influenza virus, live or dead, can provoke an increase in antibody to a cross-reacting antigen present on neuraminidase-treated human lymphocytes.
mesh_terms: D000293:Adolescent; D000328:Adult; D000906:Antibodies; D002648:Child; D003429:Cross Reactions; D005260:Female; D006801:Humans; D066298:In Vitro Techniques; D009980:Influenza A virus / Q000276:immunology; D007251:Influenza, Human / Q000276:immunology*; D008214:Lymphocytes / Q000187:drug effects / Q000276:immunology*; D008297:Male; D008875:Middle Aged; D009439:Neuraminidase / Q000494:pharmacology
chemical_list: D000906:Antibodies; D009439:Neuraminidase