Catabolism of thymidine during the lymphocyte cell cycle.
Concanavalin A-stimulated lymphocytes degrade thymidine to beta-aminoisobutyric acid. Thymidine-catabolizing enzymes are active in the cells during G1, G2 and mitosis, but activity falls to very low levels just prior to the onset of S and remains low throughout the S period. The data suggest that cell pools of thymidine are regulated by degradation.
D002453:Cell Cycle; D003208:Concanavalin A; D004247:DNA / Q000096:biosynthesis; D007399:Interphase; D008213:Lymphocyte Activation; D008214:Lymphocytes / Q000166:cytology / Q000378:metabolism*; D008938:Mitosis; D013936:Thymidine / Q000378:metabolism*
D003208:Concanavalin A; D004247:DNA; D013936:Thymidine