[Inflammation and host resistance against tumours. I. Delayed growth of Lewis tumour and inhibition of lung metastasis in mice having an inflammatory reaction distant from the inoculation site of tumour cells (author's transl)].
Following the inflammatory reaction induced in mice by subcutaneous implantation into the dorsal area of talc embeded in a calcium phosphate gel, the growth of the Lewis tumour was found to be delayed. This delay was observed even with inocula 1,000 times higher than the minimum required for the development in tumours in all animals. When 10(6) tumour cells were inoculated subcutaneously into the footpad, in contrast with normal animals, no metastases were found in the lungs if inflammatory reactions were induced 4 days before or 1 day after the inoculation of tumour cells.
D000818:Animals; D002471:Cell Transformation, Neoplastic; D005260:Female; D007249:Inflammation; D008175:Lung Neoplasms / Q000276:immunology*; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D009362:Neoplasm Metastasis; D009374:Neoplasms, Experimental / Q000276:immunology* / Q000517:prevention & control; D013997:Time Factors
Inflammation et résistance antitumorale. I. Retard de croissance et inhibition du développement des métastases de la tumeur de Lewis chez des souris porteuses d'une réaction inflammatoire distante du site d'inoculation des cellules malignes.