title: Analysis of the cores of ferruginous (asbestos) bodies from the general population. I. Patients with and without lung cancer.
abstract: Ferruginous (asbestos) bodies may be found in the lungs of almost everyone in the population, but little information is available as to whether such bodies are nucleated on asbestos or on some other fibrous dust. In this study morphologically "typical" ferruginous bodies were isolated from the lungs of 23 autopsy and surgical patients, none of whom had primary asbestos exposure. Eleven patients had carcinoma of the lung. To determine the nature of the core, 328 bodies were examined by electron diffraction. Of these, 264 (80%) showed the diffraction patterns of amphibole asbestos, whereas six showed the pattern of chrysotile asbestos. No amorphous cores or crystalline nonasbestos cores were identified. Fifty-eight (18%) bodies could not be diffracted because of the thickness of the iron-protein coat. No differences were seen between patients with and without lung cancer. We conclude that typical ferruginous bodies have asbestos cores, which are usually amphibole type. The findings suggest widespread exposure to asbestos dust; occupational histories appeared to indicate the source of exposure in some but not all patients.
mesh_terms: D000368:Aged; D001194:Asbestos / Q000032:analysis; D002283:Carcinoma, Bronchogenic / Q000032:analysis / Q000648:ultrastructure*; D005260:Female; D006801:Humans; D007501:Iron; D008168:Lung / Q000648:ultrastructure*; D008175:Lung Neoplasms / Q000032:analysis / Q000648:ultrastructure*; D008297:Male; D008875:Middle Aged
chemical_list: D001194:Asbestos; D007501:Iron