Drug treatment of malignant hyperpyrexia.
Of the various drugs currently suggested for the treatment of malignant hyperpyrexia, dantrolene sodium was the most effective in reversing and inhibiting drug induced contractures in vitro, both in normal muscle and in muscle from patients who are susceptible to malignant hyperpyrexia. It is suggested that dantrolene sodium is the drug of choice for lowering the raised myoplasmic calcium concentrations in malignant hyperpyrexia.
D002110:Caffeine / Q000494:pharmacology; D002118:Calcium / Q000378:metabolism; D003620:Dantrolene / Q000494:pharmacology / Q000627:therapeutic use*; D006801:Humans; D006827:Hydantoins / Q000627:therapeutic use*; D008305:Malignant Hyperthermia / Q000188:drug therapy*; D009119:Muscle Contraction / Q000187:drug effects; D009132:Muscles / Q000378:metabolism; D011343:Procaine / Q000627:therapeutic use
D006827:Hydantoins; D002110:Caffeine; D011343:Procaine; D003620:Dantrolene; D002118:Calcium