[Distribution of gamma-hydroxybutyric acid in different portions of the brain and in the serum of rats during anesthesia].
Dynamics of gamma-hydroxybutyric acid (GHBA) accumulation in different parts of the rat brain (the thalamus, hypothalamus, cerebellum, corpus striatum, cerebral hemispheres, medulla oblongata, corpora duadrigemina) and in the serum was studied by the improved gas-chromatographic method after intraperitoneal injection of gamma sodium oxybutyrate (1.5 g/kg). The GHBA content failed to differ much in the brain parts under study at the beginning of anesthesia, during and after it, only a somewhat higher GHBA content was seen at all the periods of anesthesia in the cerebral hemisphere, cerebellum, and corpus striatum. The GHBA level was constantly higher (especially at the initial period of anesthesia in the serum, then in the brain tissue.
D000768:Anesthesia, General; D000818:Animals; D001921:Brain / Q000378:metabolism*; D006885:Hydroxybutyrates / Q000008:administration & dosage / Q000097:blood / Q000378:metabolism*; D007274:Injections, Intraperitoneal; D008297:Male; D051381:Rats; D013997:Time Factors
D006885:Hydroxybutyrates
Raspredelenie gamma-oksimaslianoĭ kisloty v razlichnykh otdelakh golovnogo mozga i syvorotke krovi v dinamike razvitiia narkoza u krys.