title: [The action of high-concentrated fibria on bone healing (author's transl)].
abstract: The influence of a biological tissue glue--based on fibrinogen clotting--on bone healing has been investigated in animal experiments. Standardized cortical defects in the tibiae of rabbits were closed with a plug of homologous or heterologous fibrin. The course of restoration has been studied using histological techniques, x-ray examinations and isotopes (Ci 99 TC). Heterologous fibrin delays bone formation, due to a local immune response. Homologous fibrin on the other hand cubances and accelerates sprouting of capillary vessels and connective tissue cells which results in rapid new formation of bone.
mesh_terms: D000818:Animals; D001842:Bone and Bones / Q000187:drug effects*; D002196:Capillaries; D003238:Connective Tissue; D005260:Female; D005337:Fibrin / Q000494:pharmacology*; D008297:Male; D011817:Rabbits; D011877:Radionuclide Imaging; D013977:Tibia / Q000000981:diagnostic imaging; D014945:Wound Healing / Q000187:drug effects*
chemical_list: D005337:Fibrin
vernacular_title: Die Beeinflussung der Knochenheilung durch hochkonzentrierties Fibrin.