title: A servo controlled transapical left ventricular to aortic assist device with implantable canulae.
abstract: A servo controlled transapical LV to aortic bypass system employing a roller pump was evaluated. The pump achieved complete LV decompression with reduction of LV pressure below systemic pressure. The servo control was responsive to LA pressure and allowed stable complete bypass during interventions designed to raise and lower LA pressure. A permanently implantable transapical LV cannula and aortic cannula without obturators was evaluated with and without anticoagulants. The teflon felt surface 'healed' rapidly and developed a multi-layered fibrous pseudointima. Anticoagulants appeared to avoid excessive thrombus formation at the cannula sites and embolization.
mesh_terms: D000818:Animals; D000925:Anticoagulants / Q000627:therapeutic use; D001794:Blood Pressure; D006328:Cardiac Catheterization / Q000009:adverse effects; D004285:Dogs; D004617:Embolism / Q000517:prevention & control; D006355:Heart-Lung Machine; D008854:Microscopy, Electron; D011138:Polytetrafluoroethylene; D011183:Postoperative Complications / Q000517:prevention & control
chemical_list: D000925:Anticoagulants; D011138:Polytetrafluoroethylene