title: Lack of mutagenic effect of halothane or chloroform on cultured cells using the azaguanine test system.
abstract: Halothane with and without nitrous oxide and chloroform alone were tested for mutagenic effects at the 8-azaguanine locus on the chromosomes of Chinese hamster lung fibroblast cells in culture. No significant numbers of mutations were found after 24 h exposures to 1-3% of these anaesthetics, or to 75% nitrous oxide.
mesh_terms: D000818:Animals; D001375:Azaguanine / Q000378:metabolism; D002460:Cell Line; D002725:Chloroform / Q000494:pharmacology*; D006224:Cricetinae; D003412:Cricetulus; D006221:Halothane / Q000494:pharmacology*; D066298:In Vitro Techniques; D009154:Mutation / Q000187:drug effects*; D009609:Nitrous Oxide / Q000494:pharmacology
chemical_list: D002725:Chloroform; D009609:Nitrous Oxide; D001375:Azaguanine; D006221:Halothane