title: Cutting fluids and their effects on the skin of mice. An experimental study with special reference to carcinogenicity.
abstract: Reports of skin malignancies due to occupational exposure have decreased since the introduction of solvent-refining of mineral oil fraction in the manufacture of oil based cutting fluids. Commercial mineral oil based cutting fluids caused local and general pathological changes after repeated application to the skin of mice in the present study. Forty-eight per cent of the mice exposed to oils showed severe dysplasia or malignancy of the skin on histological examination. The corresponding figure for the control group, where various additives were used was 8 per cent. The frequency of papillomas was also increased in the mice exposed to oils. The systemic lesions included focal necrosis of the liver, associated with amyloid deposition, as well as amyloidosis of the skin, spleen and kidneys. The substances responsible for these apparent carcinogenic properties of the complex mixtures may be polycyclic hydrocarbons; the latter are still present in the commercial products despite solvent refining; on the other hand the carcinogens may be additives to the cutting oils the composition of which is generally a trade secret.
mesh_terms: D000686:Amyloidosis / Q000139:chemically induced / Q000473:pathology; D002273:Carcinogens; D009336:Necrosis; D009374:Neoplasms, Experimental / Q000139:chemically induced / Q000473:pathology; D009821:Oils / Q000633:toxicity*; D012867:Skin / Q000187:drug effects* / Q000473:pathology; D012878:Skin Neoplasms / Q000139:chemically induced* / Q000473:pathology
chemical_list: D002273:Carcinogens; D009821:Oils