Membranes undergoing phase transitions are preferentially hydrolyzed by beta-bungarotoxin.
beta-Bungarotoxin preferentially hydrolyzes choline phospholipids (dilauroyl, dimyristoyl, dipalmitoyl) at their respective gel to liquid crystalline phase transition temperatures. Cholesterol markedly reduces the rate of phospholipid hydrolysis; at 0.33 mol percent cholesterol:phospholipid, the toxin's phospholipase activity is completely inhibited.
D002038:Bungarotoxins / Q000378:metabolism*; D002784:Cholesterol / Q000378:metabolism; D006868:Hydrolysis; D008081:Liposomes / Q000378:metabolism*; D010713:Phosphatidylcholines / Q000378:metabolism*; D010740:Phospholipases / Q000378:metabolism; D013696:Temperature
D002038:Bungarotoxins; D008081:Liposomes; D010713:Phosphatidylcholines; D002784:Cholesterol; D010740:Phospholipases