Consumptive coagulopathy as biochemical mechanism in oxygen toxicity and its enhancement by lead(II) ions.
Consumptive coagulopathy and disseminated intravascular coagulation can be observed in rats exposed to 4 ata of oxygen. These events clearly precede the death of the animal and appear to be initiated by an activation of coagulation factor XII (Hageman). The onset and the extent of consumptive coagulapathy are greatly enhanced by a single and low intravenous dose of lead acetate. Mechanisms of activation of the intrinsic coagulation system and its role in oxygen toxicity are being discussed.
D000818:Animals; D001778:Blood Coagulation Disorders / Q000139:chemically induced* / Q000150:complications / Q000473:pathology; D005337:Fibrin / Q000502:physiology; D007854:Lead; D007855:Lead Poisoning / Q000150:complications* / Q000473:pathology; D008168:Lung / Q000473:pathology / Q000648:ultrastructure; D008297:Male; D008854:Microscopy, Electron; D010100:Oxygen / Q000633:toxicity; D011517:Prothrombin Time; D051381:Rats; D013045:Species Specificity; D013925:Thromboplastin / Q000502:physiology
D007854:Lead; D005337:Fibrin; D013925:Thromboplastin; D010100:Oxygen