[Hydroxyproline in the diagnosis of bone metastases in breast cancer].
15 patients with breast cancer and proven bone metastases have been studied. Free serum and total urinary hydroxyproline were measured and the ratio (hydroxyproline/creatinine) - 100 in a morning urine specimen was calculated. The preliminary results show elevated free serum hydroxyproline in 8 of 15 patients; total urinary hydroxyproline in a 24-h collection and the ratio hydroxyproline/creatine in a morning urine specimen were elevated in all cases. These results agree with those of the literature. Further studies of free hydroxyproline and of the ratio hydroxyproline/ creatinine in a morning urine specimen in similar patients with provide more information on the possibility of using these measurements, alone or in combination, for the early detection or follow-up under therapy of bone metastases.
D000328:Adult; D000368:Aged; D001859:Bone Neoplasms / Q000175:diagnosis / Q000652:urine*; D001943:Breast Neoplasms / Q000175:diagnosis / Q000652:urine*; D003404:Creatinine / Q000652:urine; D005188:False Negative Reactions; D005260:Female; D006801:Humans; D006909:Hydroxyproline / Q000652:urine*; D008875:Middle Aged; D009362:Neoplasm Metastasis / Q000652:urine*; D013997:Time Factors
D003404:Creatinine; D006909:Hydroxyproline
Etude de l'hydroxyproline dans le diagnostic des métastases osseuses du cancer du sein.