The relation between baseline and 150 min platelet counts in response to selective beta-1-receptor blockade. An experimental study on healthy subjects.
In 30 healthy volunteers after an oral administration of 50 mg metoprolol basal and 150 min platelet counts were determined. A significant negative correlation (p less than 0.01) between the baseline platelet count and the percentage increase at 150 min was shown to be present. It is postulated that this observation reflects interindividual differences between the magnitude of the exchangeable splenic platelet pool.
D000284:Administration, Oral; D000293:Adolescent; D000328:Adult; D001772:Blood Cell Count; D001792:Blood Platelets / Q000187:drug effects*; D004837:Epinephrine / Q000494:pharmacology; D005260:Female; D006801:Humans; D008297:Male; D008790:Metoprolol / Q000008:administration & dosage / Q000494:pharmacology*; D008875:Middle Aged; D011412:Propanolamines / Q000494:pharmacology*; D013997:Time Factors
D011412:Propanolamines; D008790:Metoprolol; D004837:Epinephrine