Age-dependent modulation of 3'-phosphoadenosine-5'-phosphosulfate-galactosylceramide sulfotransferase by lipids extracted from the microsomal membranes and artificial lipid mixtures.
The 3'-phosphoadenosine-5'-phosphosulfate-galactosylceramide-sulfotransferase (cerebroside sulfotransferase) is microsomal enzyme, which shows a definite developmental activity pattern. This report gives evidence that the enzyme activity of partially delipidated microsomes is modulated by the cholesterol:phospholipid ratio of the extracted microsomal lipids in an age-dependent manner. These findings suggest that in vivo the enzyme activity is modulated by the lipid surrounding.
D000249:Adenosine Monophosphate; D000375:Aging; D001921:Brain / Q000201:enzymology; D002554:Cerebrosides; D002784:Cholesterol / Q000494:pharmacology; D008055:Lipids; D008563:Membrane Lipids; D008861:Microsomes / Q000201:enzymology*; D010743:Phospholipids / Q000494:pharmacology; D015238:Sulfotransferases; D013464:Sulfuric Acids; D013466:Sulfurtransferases / Q000378:metabolism*
D002554:Cerebrosides; D008055:Lipids; D008563:Membrane Lipids; D010743:Phospholipids; D013464:Sulfuric Acids; D000249:Adenosine Monophosphate; D002784:Cholesterol; D013466:Sulfurtransferases; D015238:Sulfotransferases; C020556:galactosylceramide sulfotransferase