[Experimental examinations about the proliferation and radiotherapy after administration of Vincristin and Adriamycin (author's transl)].
Cytophotometric examinations of solid carcinomas of Ehrlich in mice don't show a considerable cyto-cinetic effect after administration of Vincristin. On the other hand, Adriamycin causes in the same tumor a significant stop in the G2 + M phase with a synchronization factor of 1,4 to 1,5 related to G2. The following experiment with the combined Adriamycin and radiotherapy demonstrates with a statistical significance lying about 5% that an immediate radiotherapeutic success can be obtained which is even increased by a partial synchronization. A considerably enriched G2 + M phase as a result of the administration of Adriamyzin is proven by a first cyto-cinetic examination of human cancerous tissue. A possible clinical therapy scheme is discussed.
D000818:Animals; D002286:Carcinoma, Ehrlich Tumor / Q000532:radiotherapy; D002455:Cell Division / Q000187:drug effects* / Q000528:radiation effects; D004317:Doxorubicin / Q000494:pharmacology*; D051379:Mice; D011878:Radiotherapy; D013997:Time Factors; D014750:Vincristine / Q000494:pharmacology*
D014750:Vincristine; D004317:Doxorubicin
Experimentelle Untersuchungen zur Proliferationskinetik und Strahlenbehandlung nach Vincristin und Adriamycin.