[Endocrinopathy due to intracranial aneurysm (Part I)--Direct kinetic effect of aneurysm on the hypothalamo pituitary system (author's transl)].
Intracranial aneurysm rarely causes endocrinopathy clinically, however, many laboratory data show abnormality concerning endocrine function. To elucidate the reasons of these endocrine dysfunction, the authors investigated several representative patients in our department and the reported cases. The major part of reported cases suggests that the direct kinetic effect of aneurysms on the hypothalamopituitary system resulted in the endocrinopathy. The common features are described as follows. 1) Aneurysm were of large size. 2) Most aneurysms were located at the intracranial internal carotid artery. 3) They had no previous history of SAH usually. 4) Visual impairment was one of the common manifestation among them. 5) The higher frequency of the reported pituitary dysfunction in laboratory examination was shown in the following turn. However, some of our cases did not always agree with the reported ones. SAH operation etc. were considered to be the reasons of this discrepancy.
D000172:Acromegaly / Q000209:etiology; D000328:Adult; D004700:Endocrine System Diseases / Q000209:etiology; D005260:Female; D013006:Growth Hormone / Q000378:metabolism; D006801:Humans; D007030:Hypothalamo-Hypophyseal System / Q000503:physiopathology*; D007037:Hypothyroidism / Q000209:etiology; D002532:Intracranial Aneurysm / Q000150:complications / Q000503:physiopathology*; D008297:Male; D008875:Middle Aged
D013006:Growth Hormone