title: Injectable collagen for soft tissue augmentation.
abstract: Collagen from allogenic and xenogeneic sources has been made soluble by controlled proteolytic digestion. The monomeric, telopeptide-poor collagen so prepared forms a cohesive mass when warmed to body temperature (upon injection), creating a structural basis for new soft connective tissue. We have treated 28 patients with human and/or bovine collagen injections for the correction of soft tissue contour defects, and we have followed them for 3 to 18 months. In most instances, there has been lasting and substantial correction of the defects treated. The complications have been few and transient.
mesh_terms: D000153:Acne Keloid / Q000628:therapy*; D000818:Animals; D002417:Cattle; D002481:Cellulitis / Q000139:chemically induced; D003094:Collagen / Q000009:adverse effects / Q000302:isolation & purification / Q000627:therapeutic use*; D005260:Female; D005499:Folliculitis / Q000628:therapy*; D005500:Follow-Up Studies; D006801:Humans; D007271:Injections, Intradermal; D007279:Injections, Subcutaneous; D008297:Male; D010859:Pigmentation Disorders / Q000139:chemically induced; D051381:Rats; D012871:Skin Diseases / Q000628:therapy; D013518:Surgery, Plastic / Q000379:methods*; D014184:Transplantation, Homologous; D014581:Urticaria / Q000139:chemically induced
chemical_list: D003094:Collagen