Synthesis of some dibenzazepines of possible therapeutic interest.
Among the hypotensive drugs are the N-alkyldibenz[c,e]-azepines. A representative of this class is 6-allyl-6,7-dihydro-5H-dibenz[c,e]azepine (azapetine). The present investigation involved the preparation of a new series of N-[6,7-dihydro-5H-dibenz[c,e]azepin-6-yl] acid amides namely; acetamide, benzamide, phehyl acetamide, salicylamide and p-hydroxybenzamide derivatives. Another new series of N-[6,7-dihydro-5H-dibenz[c,e]azepin-6-yl]-N-alkyl (or aryl) thioureas was prepared namely ethyl, isopropyl, butyl, cyclohexyl, benzyl, phenyl and o-tolyl thiourea derivatives. IR spectra of the two series of compounds were investigated.
D000959:Antihypertensive Agents / Q000138:chemical synthesis; D055598:Chemical Phenomena; D002621:Chemistry; D003984:Dibenzazepines / Q000138:chemical synthesis*; D007202:Indicators and Reagents; D007536:Isomerism; D013055:Spectrophotometry, Infrared
D000959:Antihypertensive Agents; D003984:Dibenzazepines; D007202:Indicators and Reagents