title: Evolutionary adaptability of biological macromolecules.
abstract: The degree of gradualism with which tertiary structure and function of protein changes with stepwise changes in primary structure (assumed to be influenced by redundancy of weak bonding) is both a precondition for and consequence of evolution. The resulting selection for degree of gradualism has implications for a number of structural and functional properties of modern proteins as well as for the significance of neutral (so-called non-Darwinian) phenomena in relation to selection.
mesh_terms: D000596:Amino Acids; D005075:Biological Evolution; D004798:Enzymes; D007527:Isoenzymes; D011487:Protein Conformation; D011506:Proteins
chemical_list: D000596:Amino Acids; D004798:Enzymes; D007527:Isoenzymes; D011506:Proteins