title: [Experimental investigations on the immunity development in irradiated mice after local and parenteral immunization with tetanus-toxoid (author's transl)].
abstract: Using the "tetanus-mouse" model the differences in immunity development between animals exposed to irradiation (300 R and 400 R) and animals not exposed to irradiation after nasal and subcutaneous vaccination was investigated. Immunization was carried out 1, 3, 6 and 10 days before and after exposure to irradiation. Efficacy of immunization was tested by challenge with 10 X LD50 tetanus-toxin and by antitoxin determination with L+-method. The degree of the immune response was dependent on 1. the irradiation dose, 2. the interval between active immunization and the ensuing or preceding irradiation, 3. the mode of vaccination (local or parenteral) and 4. the vaccination dose.
mesh_terms: D000818:Animals; D005260:Female; D007109:Immunity / Q000528:radiation effects*; D007165:Immunosuppression Therapy; D051379:Mice; D011829:Radiation Dosage; D013743:Tetanus Antitoxin / Q000032:analysis; D013745:Tetanus Toxoid; D013997:Time Factors; D014611:Vaccination / Q000379:methods
chemical_list: D013743:Tetanus Antitoxin; D013745:Tetanus Toxoid
vernacular_title: Experimentelle Untersuchungen über die Entwicklung des Immunschutzes nach lokaler und parenteraler Immunisierung mit Tetanus-Toxoid bei strahlenbelasteten Mäusen.