Sesquiterpene lactones. Part XV. New cytostatic active sesquiterpene lactone from herb of Anthemis nobilis L.
From fresh and dried herb (without inflorescences) of Anthemis nobilis L. a new sesquiterpene lactone C20H26O6 was isolated. This compound showed a cytotoxic activity at a level of ED50 HeLa -- 0-56 microgram/ml (1-5 x 10(-6) M), and ED50 KB -- 1.23 microgram/ml (3-5 x 10(-6) M), what qualifies it for further in vivo studies.
D000972:Antineoplastic Agents, Phytogenic / Q000302:isolation & purification*; D006801:Humans; D007783:Lactones / Q000302:isolation & purification; D007928:Lethal Dose 50; D010946:Plants, Medicinal / Q000032:analysis*; D012717:Sesquiterpenes / Q000302:isolation & purification*
D000972:Antineoplastic Agents, Phytogenic; D007783:Lactones; D012717:Sesquiterpenes