[Metabolism of N-methyl-N-nitrosourea in various mouse tissues under inhibition of protein and nucleic acid synthesis].
The contribution of C1-pool and antimetabolite utilization to modification (labeling) of macromolecules of various mouse tissues after a single injection of 1-14C-methylnitrosourea was studied, using inhibitors of protein and nucleic acid synthesis. It was shown that about 50% of radioactivity found in the proteins, lipoproteins and DNA (but not in RNA) might be supplied by the C1-pool and/or through utilization of radioactive metabolites in the first 3-6 hours following the injection of 1-14C-methylnitrosourea. The data obtained allow to evaluete the degree of alkylation of macromolecules in various organs and tissues.
D000818:Animals; D004247:DNA / Q000096:biosynthesis; D008074:Lipoproteins / Q000096:biosynthesis; D008770:Methylnitrosourea / Q000378:metabolism*; D051379:Mice; D009607:Nitrosourea Compounds / Q000378:metabolism*; D009696:Nucleic Acids / Q000096:biosynthesis*; D014176:Protein Biosynthesis; D012313:RNA / Q000096:biosynthesis
D008074:Lipoproteins; D009607:Nitrosourea Compounds; D009696:Nucleic Acids; D012313:RNA; D008770:Methylnitrosourea; D004247:DNA
Metabolizm i-metil-i-nitrozomocheviny v razlichnykh organakh mysheĭ v usloviiakh ingibirovaniia sinteza belka i nukleinivykh kislot.