[Studies on the tolerance of the organism to X 5 CrNiMo 18.10 steel (Königsee). II. Light microscopic studies of the surrounding tissue of metal implants (X 5 CrNiMo 18.10 steel) in guinea pigs].
The tissue around X 5 CrNiMo 18.10-steel implantates with different surfaces was examined in 72 guinea-pigs. Aside from controls, these animals were preoperatively sensibilized against chromium and nickel. The results can be summarized since the histologic findings showed no different peculiarities. The authors describe an intussusception of the implantate in connective tissue which evidently depends on time and surface. Further the spreading of alien material in the surrounding of the implantate, and morphologic findings are reported. The morphologic evidences are described and discussed in detail, since they are interpreted as signs of cell-mediated immune reactions. The presence of lymphocytes, lymphoblasts, histiocytes (mostly carrying alien material), and granulocytes, as well as proliferations at the arterioles suggest an overlapping of immune reactions.
D000818:Animals; D002857:Chromium / Q000032:analysis; D003094:Collagen; D004342:Drug Hypersensitivity / Q000276:immunology*; D004343:Drug Implants; D005347:Fibroblasts; D006098:Granulocytes / Q000276:immunology; D006168:Guinea Pigs; D006644:Histiocytes / Q000276:immunology; D007111:Immunity, Cellular; D008214:Lymphocytes / Q000276:immunology; D008670:Metals; D009132:Muscles / Q000032:analysis / Q000098:blood supply / Q000473:pathology; D009532:Nickel / Q000032:analysis
D004343:Drug Implants; D008670:Metals; D002857:Chromium; D009532:Nickel; D003094:Collagen
Untersuchungen zur Verträglichkeit des X 5 CrNiMo 18.10 Stahls (Königsee) im Organismus. Teil II: Lichtmikroskopische Untersuchungen des Umgebungsgewebes metallischer Implantate (X 5 CrNiMo 18.10 Stahl) bei Meerschweinchen.