Simultaneous protective effect of a new chelating agent and zinc, on the carbon tetrachloride induced hepatic injury in squirrels.
An attempt has been made to study the protective effect of a new chelating agent named p-amino salicylic acid oxine azo dye complex and metallic zinc on the Ccl4 induced hepatic injury in squirrels. This is probably the first multidisciplinary approaching (histological, histochemical and biochemical), report, employing this chelating agent and zinc together in the cure of a hepatic tissue. Apart from a pathological support, biochemical estimation of two enzymes noticed: Viz glucose-6-phosphatase dehydrogenase and beta-glucuronidase were treated as enzymatic denominators in liver cure. It further claims the suitability of the drug for clinical use. However, a detailed mechanism of action of this chelating agent remains practically unknown. It is hypothesized, that chelation of zinc facilitates the peneteration of a drug complex in the hepatic cells. Further zinc serves the purpose of drug transporter. The chelating agent masks the toxic substances (metabolites of Ccl4), which are eventually excreted, but still bound to it. The regeneration progresses speedily after the biomembranes are stabilized.
D010131:Aminosalicylic Acid / Q000627:therapeutic use*; D000636:Aminosalicylic Acids / Q000627:therapeutic use*; D000818:Animals; D001391:Azo Compounds / Q000627:therapeutic use*; D002252:Carbon Tetrachloride Poisoning / Q000517:prevention & control*; D002614:Chelating Agents / Q000627:therapeutic use*; D056486:Chemical and Drug Induced Liver Injury; D004359:Drug Therapy, Combination; D005260:Female; D005954:Glucosephosphate Dehydrogenase / Q000378:metabolism; D005966:Glucuronidase / Q000378:metabolism; D008099:Liver / Q000201:enzymology / Q000378:metabolism / Q000473:pathology; D008107:Liver Diseases / Q000473:pathology / Q000517:prevention & control; D008297:Male; D012589:Sciuridae; D015032:Zinc / Q000378:metabolism / Q000627:therapeutic use*
D000636:Aminosalicylic Acids; D001391:Azo Compounds; D002614:Chelating Agents; D010131:Aminosalicylic Acid; D005954:Glucosephosphate Dehydrogenase; D005966:Glucuronidase; D015032:Zinc