A novel class of antitumour agents. III. Morphological findings in treated cells.
The findings of intracellular light-reflecting droplets and clotted mitoses after incubation of Walker and HeLa cells, human lymphocytes and rat fibroblasts with the synthetic amino steroid, 2beta, 16beta-dipiperidino-5alpha-androstane-3-alpha,17beta-diol dipivalate (DAP) were examined in detail. An interaction of DAP with the cellular membranes in all stages of cell life, with the exception of the Go-phase, is postulated.
D000970:Antineoplastic Agents; D002467:Cell Nucleus / Q000187:drug effects; D002478:Cells, Cultured; D003593:Cytoplasm / Q000187:drug effects; D006801:Humans; D066298:In Vitro Techniques; D007399:Interphase / Q000187:drug effects; D008214:Lymphocytes / Q000166:cytology / Q000187:drug effects; D008566:Membranes / Q000187:drug effects*; D008938:Mitosis / Q000187:drug effects; D009685:Nuclear Envelope / Q000187:drug effects; D010197:Pancuronium / Q000031:analogs & derivatives* / Q000494:pharmacology
D000970:Antineoplastic Agents; D010197:Pancuronium