[Conformational changes of erythrocyte membranes under the influence of biologically active substances].
As a result of studying rabbit erythrocyte membranes by using infrared spectroscopy method the absorption bands 1635 cm-1, 1645 cm-1, 1685 cm-1, 1695 cm-1 that probably belong to beta-structure of protein membranes have been discovered. The increase of the intensity of these bands under the influence of carbochol or eserine on membranes corresponds to increasing the lobe of beta-structure. The increase of theintensity of absorbtion bands corresponding to beta-structure and the change of intensity of absorption band of amide-1 in the field 1650-1662 cm-1 relating to alpha-helical and unordered structure are due to alpha leads to beta-transition in contractile protein. The change of a half of width of absorption band of amides A 3310 cm-1 under the influence of carbochol and other substances on cholinereactive systems has been found. This change correlates with the intensity of bands corresponding to beta-structure.
D000818:Animals; D002217:Carbachol / Q000494:pharmacology*; D003285:Contractile Proteins; D004910:Erythrocyte Membrane / Q000187:drug effects / Q000648:ultrastructure; D004912:Erythrocytes / Q000648:ultrastructure; D008565:Membrane Proteins; D010830:Physostigmine / Q000494:pharmacology*; D011487:Protein Conformation; D011817:Rabbits; D013055:Spectrophotometry, Infrared
D003285:Contractile Proteins; D008565:Membrane Proteins; D002217:Carbachol; D010830:Physostigmine
Konformatsionnye izmeneniia v membranakh eritrotsitov pri deĭstvii na nikh biologicheski aktivnykh veshchestv.