Glomerulonephritis associated with hepatitis B. report of a case and review of the literature.
A 45-year old developed membranoproliferative GN seven years after acute hepatitis. He was found to be a chronic carrier of HBsAg, and glomeruli contained granular deposits of immunoglobulins (Ig), complement (C) and HBsAg. Six months later, HN persisted, but HBsAg has disappeared from glomeruli; Ig and C were still present. It was concluded that GN was probably due to a hepatitis B associated antigen, but not necessarily to HBsAg.
D000208:Acute Disease; D000936:Antigen-Antibody Complex; D003176:Complement C3 / Q000032:analysis; D003181:Complement C4 / Q000032:analysis; D005921:Glomerulonephritis / Q000209:etiology*; D006509:Hepatitis B / Q000150:complications*; D006514:Hepatitis B Surface Antigens / Q000009:adverse effects / Q000032:analysis; D006801:Humans; D007070:Immunoglobulin A / Q000032:analysis; D007074:Immunoglobulin G / Q000032:analysis; D007075:Immunoglobulin M / Q000032:analysis; D007678:Kidney Glomerulus / Q000276:immunology; D008297:Male; D008875:Middle Aged; D013997:Time Factors
D000936:Antigen-Antibody Complex; D003176:Complement C3; D003181:Complement C4; D006514:Hepatitis B Surface Antigens; D007070:Immunoglobulin A; D007074:Immunoglobulin G; D007075:Immunoglobulin M