Intracellular recording of cerebral cortical actions of prostaglandins F2alpha (PGF2alpha).
Our reported data on the cortical inhibitory actions of prostaglandin F2alpha (PGF2alpha) and the diversity of data in the literature on cerebral PG actions are examined here in the light of intracellular recording which provides the requisite membrane data for the first time. Thus, 1) intracellular recording from the cat cerebral cortex is obtained for the actions of PGF2alpha and for norepinephrine (NE) and serotonin (5HT). 2) The parallel changes in firing and polarization and the simultaneous transmembrane conductance changes are qualitatively identical for PGF2alpha, NE and 5HT. 3) The reduction in firing accompanied by hyperpolarization indicates that PGF2alpha, NE and 5HT all inhibit these cells. 4) The ionic species responsible for this inhibition is such that it increased the transmembrane resistance, and this was true for all three. 5) The changes in membrane parameters, identical in direction for PGF2alpha and NE, but stronger for the latter, constitute conditions that can lead to competitive inhibition and therefore connote, presumably, actions at the same or related receptors. Such competition with evoked cortical field potentials is shown in the preceding paper.
D000818:Animals; D002415:Cats; D002462:Cell Membrane / Q000187:drug effects; D002540:Cerebral Cortex / Q000187:drug effects*; D003864:Depression, Chemical; D005071:Evoked Potentials / Q000187:drug effects*; D009638:Norepinephrine / Q000494:pharmacology; D011460:Prostaglandins F / Q000494:pharmacology*; D012701:Serotonin / Q000494:pharmacology
D011460:Prostaglandins F; D012701:Serotonin; D009638:Norepinephrine