Urinary catecholamine metabolites in hyperkinetic boys treated with d-amphetamine.
The authors studied the excretion of 3-methoxy-4-hydroxyphenyl glycol (MHPG), normetanephrine (NM), metanephrine, and homovanillic acid in 7 hyperactive and 12 control children. MHPG was lower but NM was significantly higher in hyperactive children than in controls. Administration of d-amphetamine for 2 weeks depressed the levels of MHPG, NM, and metanephrine. The authors suggest a decreased central norepinephrine activity, which may be secondary to the interruption of norepinephrine fibers in the medial forebrain bundle.
D002648:Child; D003864:Depression, Chemical; D003913:Dextroamphetamine / Q000494:pharmacology / Q000627:therapeutic use*; D004305:Dose-Response Relationship, Drug; D004837:Epinephrine / Q000378:metabolism*; D006719:Homovanillic Acid / Q000652:urine; D006801:Humans; D006948:Hyperkinesis / Q000188:drug therapy / Q000652:urine*; D008297:Male; D008676:Metanephrine / Q000652:urine; D008734:Methoxyhydroxyphenylglycol / Q000652:urine; D009647:Normetanephrine / Q000652:urine
D009647:Normetanephrine; D008676:Metanephrine; D008734:Methoxyhydroxyphenylglycol; D003913:Dextroamphetamine; D006719:Homovanillic Acid; D004837:Epinephrine