title: Viability and metabolic activity of homozygous Brachyury (T) embryos.
abstract: Some features of metabolic activity of homozygous mutants for the Brachyury (T) mutation were studied. The embryos incorporated tritum-labelled thymidine up to about the '32-36 somite' stage. The total amount of protein per embryo increased until the samge stage. T/T cells proved viable in vitro over the in utero lethal period. Several cell lines were established from +/+ and T/T embryonic cells.
mesh_terms: D000818:Animals; D002470:Cell Survival; D005865:Gestational Age; D066298:In Vitro Techniques; D051379:Mice / Q000196:embryology*; D008938:Mitosis; D009154:Mutation; D014176:Protein Biosynthesis; D013936:Thymidine / Q000378:metabolism
chemical_list: D013936:Thymidine