In vivo response of ornithine decarboxylase activity to growth hormone as demonstrated by oxidation of L-ornithine-1-14C in hypophysectomized rats.
An in vivo response of ornithine decarboxylase activity to growth hormone has been demonstrated. In hypophysectomized rats, found to oxidize ornithine at rates comparable to those of normal rats, an acute treatment of growth hormone 4 hours before injection of L-ornithine-1-14C caused a 39% increase in the peak specific activity of carbon dioxide and a 24% increase in the 14CO2 recovered in 5 hours. However, response was not observed when growth hormone was administered chronically rather than acutely.
D000818:Animals; D002262:Carboxy-Lyases / Q000378:metabolism*; D004305:Dose-Response Relationship, Drug; D004790:Enzyme Induction / Q000187:drug effects; D013006:Growth Hormone / Q000008:administration & dosage / Q000494:pharmacology*; D007016:Hypophysectomy; D008297:Male; D009952:Ornithine / Q000378:metabolism; D009955:Ornithine Decarboxylase / Q000096:biosynthesis / Q000378:metabolism*; D051381:Rats; D013997:Time Factors
D013006:Growth Hormone; D009952:Ornithine; D002262:Carboxy-Lyases; D009955:Ornithine Decarboxylase