Piperidine derivatives: synthesis of potential analgesics in 3-substituted 4-phenylpiperidine series.
The syntheses of 1-methyl-3-(3-hydroxy-3-phenylpropyl)-4-phenyl-4-piperidinol and 1-methyl-3(3-hydroxy-3-phenylpropyl)-4-phenyl-4-propanoyloxypiperidine are described. Preliminary pharmacological testing showed these compounds to be weakly active in the writhing  test.
D000700:Analgesics / Q000138:chemical synthesis*; D000818:Animals; D009682:Magnetic Resonance Spectroscopy; D051379:Mice; D010880:Piperidines / Q000138:chemical synthesis* / Q000494:pharmacology; D011930:Reaction Time / Q000187:drug effects
D000700:Analgesics; D010880:Piperidines