title: Multiple system degeneration and involving thalamus, reticular formation, pallido-nigral, pallido-luysian and dentato-rubral systems. A case report.
abstract: An autopsy case of multiple system degeneration is characterized by the following; (1) progressive dementia and abnormal sleep patterns, followed by Parkinsonian symptoms with terminal akinetic mutism; (2) severe symmetrical degeneration in the thalamus, particularly nucl. medialis thalami, the reticular formation of the brain stem, also the pallidonigral, pallido-Luysian and dentato-rubral systems. As far as we known, there is no case in the literature, of combined system degeneration, which shows such a wide anatomical range of lesions as the present one. Clinico-pathological correlation between dementia and degeneration of the thalamus, and between abnormal sleep-consciousness mechanism and degeneration of the reticular formation are discussed. The extrapyramidal symptoms are discussed from the clinico-pathological aspect. In addition, peculiar eosinophilic bodies are described, which were most frequently found in the putamen.
mesh_terms: D000328:Adult; D000405:Akinetic Mutism / Q000473:pathology; D001344:Autopsy; D001921:Brain / Q000473:pathology; D001927:Brain Diseases / Q000473:pathology*; D001933:Brain Stem / Q000473:pathology; D003704:Dementia / Q000473:pathology; D006970:Disorders of Excessive Somnolence / Q000473:pathology; D006801:Humans; D008297:Male; D011699:Putamen / Q000473:pathology; D012154:Reticular Formation / Q000473:pathology; D013788:Thalamus / Q000473:pathology