Central and peripheral noradrenaline in the two kidney model of renovascular hypertension in the rat.
1 Plasma noradrenaline concentrations were similar in rats following unilateral renal arterial constriction (two kidney Goldblatt model) and in sham-operated control rats. 2 The development of hypertension was not affected by pretreatment with intracisternal injections of 6-hydroxydopamine. 3 These data suggest that sympathetic mechanisms do not contribute to the development of hypertension in this model.
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D006892:Hydroxydopamines / Q000494:pharmacology; D006977:Hypertension, Renal / Q000503:physiopathology*; D008297:Male; D009638:Norepinephrine / Q000008:administration & dosage / Q000494:pharmacology*; D051381:Rats; D013997:Time Factors
D006892:Hydroxydopamines; D009638:Norepinephrine