Plasmid-mediated resistance to gentamicin in Staphylococcus aureus.
Two strains isolated from a recent outbreak of infections by gentamicin-resistant Staphylococcus aureus were examined to determine whether genetic control of this resistance is plasmid or chromosomally mediated. Curing techniques indicated a plasmid location in both strains. Physical isolation and characterization of the plasmid deoxyribonucleic acid from one strain revealed that the determinant for gentamicin resistance resides on a 50S plasmid.
D004269:DNA, Bacterial / Q000032:analysis; D004352:Drug Resistance, Microbial; D005839:Gentamicins / Q000494:pharmacology*; D010957:Plasmids; D012293:Rifampin / Q000494:pharmacology; D013211:Staphylococcus aureus / Q000187:drug effects*; D013696:Temperature
D004269:DNA, Bacterial; D005839:Gentamicins; D012293:Rifampin