Experimentally produced resistance of Schistosoma mansoni to hycanthone.
Genetically transferred resistance to the antischistosomal drug hycanthone has been observed in several strains of Schistosoma mansoni: 1) in the progeny of worms to whose hosts hycanthone had been administered 54 to 70 days after exposure to cercariae (Type I); 2) in the progeny of worms to whose hosts hycanthone had been administered when the worms were still in an immature stage (27 to 29 days after percutaneous cercarial exposure) (Type II); and 3) in the progeny of worms from hosts that had been infected with cercariae of one sex followed by infection with the opposite sex 2 to 58 weeks later (Type III). In types I and II, drug resistance was transferred maternally. Hycanthone-resistant schistosomes were cross-resistant to antischistosomal drugs structurally related to hycanthone, such as oxamniquine and two chloro-indazole analogs of hycanthone, but not to niridazole and to another nitroheterocyclic compound.
D000818:Animals; D004351:Drug Resistance; D004996:Ethidium / Q000494:pharmacology; D005260:Female; D005796:Genes; D006824:Hybridization, Genetic; D006826:Hycanthone / Q000031:analogs & derivatives / Q000494:pharmacology*; D008297:Male; D051379:Mice; D009560:Niridazole / Q000494:pharmacology; D010073:Oxamniquine / Q000494:pharmacology; D011796:Quinacrine / Q000494:pharmacology; D012550:Schistosoma mansoni / Q000187:drug effects* / Q000254:growth & development; D013892:Thioxanthenes / Q000494:pharmacology*; D013997:Time Factors
D013892:Thioxanthenes; D010073:Oxamniquine; D006826:Hycanthone; D004996:Ethidium; D011796:Quinacrine; D009560:Niridazole