title: The effect of electrophoretic lignocaine blockade in the region of the carotid sinuses on spontaneous and water diuresis.
abstract: The effect of electrophoretic lignocaine blockade in the region of the carotid sinuses on changes in the intensity of spontaneous and water diuresis was investigated on anaesthetized dogs. After the blockade a reduction in spontaneous diuresis was observed and a marked and statistically significant restriction of water diuresis was noted as compared with the control experiments. The reduction in diuresis after the blockade was of a brief duration and did not appear to be related to changes in the intensity of the filtration through the kidneys, which was only slightly lower, but to changes in reabsorption. In all probability, the carotid blockade is connected with a dominance of hormonal effects by elimination of the effect of the nervi vagi, osmoreceptors of the carotid arteries and in particular the chemoreceptors of the carotid body.
mesh_terms: D000818:Animals; D002346:Carotid Sinus / Q000187:drug effects* / Q000294:innervation; D002628:Chemoreceptor Cells / Q000187:drug effects / Q000502:physiology; D004231:Diuresis; D004285:Dogs; D005260:Female; D007668:Kidney / Q000294:innervation; D008012:Lidocaine / Q000494:pharmacology*; D008297:Male; D009434:Neural Pathways; D014630:Vagus Nerve / Q000502:physiology
chemical_list: D008012:Lidocaine