title: [Myocardial function and metabolism during local coronary flow reduction].
abstract: In 6 open chest dogs, regional myocardial function und metabolic changes (ATP, creatine phosphate, lactate) were studied during coronary flow reduction in LAD by ultrasonic dimension gauges and transmural biopsies. After reduction of the perfusion pressure from 108 to 50 mm Hg the ischemic segment showed a marked dyskinesis: the enddiastolic segment length increased by 7%, and segment shortening and segment stroke work decreased by 22% and 63% respectively. Left ventricular (LV) enddiastolic pressure rose from 5 to 8 mm Hg (p less than 0.05). Heart rate, LV systolic pressure, LV max dP/dt and Vpm did not change significantly.
mesh_terms: D000255:Adenosine Triphosphate / Q000378:metabolism; D000818:Animals; D003326:Coronary Circulation; D004285:Dogs; D006321:Heart / Q000503:physiopathology*; D007511:Ischemia; D007773:Lactates / Q000378:metabolism; D009200:Myocardial Contraction; D009206:Myocardium / Q000378:metabolism; D010313:Partial Pressure; D010725:Phosphocreatine / Q000378:metabolism
chemical_list: D007773:Lactates; D010725:Phosphocreatine; D000255:Adenosine Triphosphate
vernacular_title: Funktion und Metabolismus des Herzmuskels unter lokaler Koronarflussdrosselung.