Half-life of cephaloridine in dogs with reduced renal function.
Various degrees of renal insufficiency were produced in 9 dogs by nephrectomy, or segmental ligation of the branches of the renal artery, or both. The serum half-life of cephaloridine, measured after a single intramuscular injection, increased progressively as renal function decreased. In dogs with 85% reduction in renal mass, serum half-life was approximately 3 times that of control dogs. To prevent accumulation of cephaloridine in dogs with renal dysfunction, a modified dose schedule was established on the basis of these experimental results.
D000818:Animals; D002509:Cephaloridine / Q000097:blood / Q000378:metabolism* / Q000652:urine; D004283:Dog Diseases / Q000378:metabolism* / Q000473:pathology; D004285:Dogs; D006207:Half-Life; D007668:Kidney / Q000473:pathology; D007676:Kidney Failure, Chronic / Q000378:metabolism / Q000473:pathology / Q000662:veterinary*; D008297:Male
D002509:Cephaloridine