[Studies of the interractions of cyclamate with phenprocomon (author's transl)].
The effect of cyclamate on the anticoagulant activity of phenprocoumon was investigated in rats after single oral doses of phenprocoumon, cyclamate, or phenprocoumon/cyclamate. By means of high pressure liquid chromatrography [HPLC] the change of the concentration of phenprocoumon per unit time in sera was determined. The anticoagulant acitivity of phenprocoumon was determined by the extension of the prothromin-time (Quick-test). It was found that cyclamate gives rise to an elevated of phenprocoumon in the blood, and a reduction of the anticoagulanting potency.
D015110:4-Hydroxycoumarins / Q000037:antagonists & inhibitors*; D000284:Administration, Oral; D000818:Animals; D001777:Blood Coagulation / Q000187:drug effects*; D003494:Cyclamates / Q000008:administration & dosage / Q000494:pharmacology*; D004347:Drug Interactions; D005260:Female; D008297:Male; D010644:Phenprocoumon / Q000008:administration & dosage / Q000037:antagonists & inhibitors* / Q000097:blood; D051381:Rats
D015110:4-Hydroxycoumarins; D003494:Cyclamates; D010644:Phenprocoumon
Zur Interaktion von Phenprocoumon mit Cyclamat.