The glycogen-depleting effect of aqueous estrone on the cerebral hemispheres of the chick embryo.
Aqueous estrone (10 to 50 pigrams/egg) was injected into the albumen of the 13 day chick embryo. The control solution and estrone carrier was 0.1 ml bacteriostatic saline. The KOH-alcohol-Anthrone colorimetric method was used to determine glycogen. 20 or more pigrams estrone/egg lowered the mean cerebral glycogen significantly (P less than 0.01) after 24 hours duration in a non-dosage-dependent manner. The glycolytic effect was demonstrated by the 20.0 pigram dosage after 120 hours duration.
D000818:Animals; D001921:Brain / Q000187:drug effects / Q000378:metabolism*; D002642:Chick Embryo; D004970:Estrone / Q000494:pharmacology*; D006003:Glycogen / Q000378:metabolism*; D066298:In Vitro Techniques; D013997:Time Factors
D004970:Estrone; D006003:Glycogen