A new anorexigen assay: stress-induced hyperphagia in rats.
Humans often respond to stress by overeating. A rat model of hyperphagia induced by a stressful tail-pinch has been described. Consumption of sweetened condensed milk by vaive rats was measured durin the stress. This milk drinking was prevented by pretreatment with d-amphetamine, chlorphentermine, diethylpropion, fenfluramine, methamphetamine, morphine, chlorpromazine and haloperidol. The benzodiazepines chlordiazepoxide and diazepam increased the hyperphagia. The relevance of dopaminergic agonistic and antagonist activities to anorexigenic activity are questioned.
D000700:Analgesics / Q000494:pharmacology; D000818:Animals; D001067:Appetite Depressants / Q000494:pharmacology*; D004327:Drinking Behavior / Q000187:drug effects; D004353:Drug Evaluation, Preclinical / Q000379:methods; D005247:Feeding Behavior / Q000187:drug effects*; D008297:Male; D051381:Rats; D013312:Stress, Physiological / Q000503:physiopathology*; D014149:Tranquilizing Agents / Q000494:pharmacology
D000700:Analgesics; D001067:Appetite Depressants; D014149:Tranquilizing Agents