[A family with hereditary hypofibrinogenemia].
A family with congenital hypofibrinogenemia (fibrinogen levels of 60-90 mg%) has been studied. Out of 19 members tested, 11 exhibit this trait, which follows a strictly autosomal-dominant pattern of inheritance. Congenital hypofibrinogenemia appears to be a separate entity which can be distinguished from heterozygous individuals of congenital afibrinogenemia and from congenital dysfibrinogenemia. A bleeding tendency of clinical significance is observed only during major surgery or after severe injury.
D000293:Adolescent; D000328:Adult; D000347:Afibrinogenemia / Q000235:genetics*; D001803:Blood Transfusion; D002648:Child; D002869:Chromosome Aberrations; D025063:Chromosome Disorders; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D007744:Obstetric Labor Complications; D010375:Pedigree; D011183:Postoperative Complications; D011247:Pregnancy; D014592:Uterine Hemorrhage / Q000209:etiology
Untersuchungen bei einer Familie mit vererbter Hypofibrinogenämie.