Duodenal mucosal damage associated with chronic use of anti-inflammatory drugs.
As duodenofiberscopy becomes popular, duodenal mucosal damage associated with aspirin ingestion has come to draw more attention than before. Duodenal mucosal injury, with or without gastric lesions, related to long-term use of anti-inflammatory drugs such as aspirin, indomethacin, ibuprofen, diclofenac or others are reported in three patients, in which the diagnosis was confirmed by emergency endoscopy after hematemesis. Some possible explanations for pathogenetic mechanisms are discussed.
D000368:Aged; D000893:Anti-Inflammatory Agents / Q000009:adverse effects*; D001241:Aspirin / Q000009:adverse effects; D004008:Diclofenac / Q000009:adverse effects; D004381:Duodenal Ulcer / Q000139:chemically induced*; D004724:Endoscopy; D005260:Female; D005336:Fiber Optic Technology; D005756:Gastritis / Q000139:chemically induced; D006801:Humans; D007052:Ibuprofen / Q000009:adverse effects; D007213:Indomethacin / Q000009:adverse effects; D007413:Intestinal Mucosa / Q000187:drug effects*; D008297:Male; D008875:Middle Aged
D000893:Anti-Inflammatory Agents; D004008:Diclofenac; D001241:Aspirin; D007052:Ibuprofen; D007213:Indomethacin