[Effect of antibiotics on cholesterol metabolism under conditions of a varying protein content in the diet].
In tests on rats subject to study were the effects of native tetracycline, thermally treated and used in doses of 100 mg/kg, of tetracycline in a dose of 20 mg/kg and of penicillin on the secretion of bile and generation of free and conjugated bile acids and cholesterol, as well as upon the cholesterol content in the blood and liver tissues with complete and protein-deficient rations. With complete ration tetracycline in its native and thermally treated forms provoked a fall in the cholesterol content in the bile and hepatic tissue, a rise in percentage of free bile acids and a decline of the tauroconjugates percentage. With a protein-low ration tetracycline called for an increased concentration of the bile cholesterol with simultaneously increasing concentration of cholic acid.
D000818:Animals; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D001646:Bile / Q000378:metabolism; D001647:Bile Acids and Salts / Q000096:biosynthesis; D002784:Cholesterol / Q000378:metabolism*; D004044:Dietary Proteins / Q000008:administration & dosage*; D004347:Drug Interactions; D008099:Liver / Q000187:drug effects / Q000378:metabolism; D008297:Male; D010406:Penicillins / Q000494:pharmacology; D051381:Rats; D013752:Tetracycline / Q000494:pharmacology; D013997:Time Factors
D000900:Anti-Bacterial Agents; D001647:Bile Acids and Salts; D004044:Dietary Proteins; D010406:Penicillins; D002784:Cholesterol; D013752:Tetracycline
Vliianie antibiotikov na obmen kholesterina v usloviiakh razlichnogo soderzhaniia belka v ratsione.