title: [Laryngeal mucosal changes experimentally produced by endogenous and exogenous factors in mice (author's transl)].
abstract: Experimentally an attempt was made to demonstrate the effects of exogenous factors on the hormonally altered laryngeal mucosa of mice. Albany mice were divided into 4 groups of 8. In the first group of males, testosterone was injected daily; in the second group of males, no testosterone was given; in the third group of females with previously removed ovaries, testosterone was given daily; and, in the fourth group of females, no testosterone was given. All 4 groups were exposed to cigarette smoke for one hour daily for six weeks. Histopathological examination of the mucosa showed that the larynx can be considered a "target" organ for male hormones and that exogenous factors produce changes that lead to malignancy.
mesh_terms: D000818:Animals; D002369:Castration; D005260:Female; D007822:Laryngeal Neoplasms / Q000139:chemically induced / Q000473:pathology; D007830:Larynx / Q000187:drug effects* / Q000473:pathology; D008297:Male; D051379:Mice; D009092:Mucous Membrane / Q000187:drug effects / Q000473:pathology; D009374:Neoplasms, Experimental / Q000139:chemically induced / Q000473:pathology; D011230:Precancerous Conditions / Q000473:pathology; D012907:Smoking / Q000150:complications*; D013739:Testosterone / Q000494:pharmacology*
chemical_list: D013739:Testosterone
vernacular_title: Veränderungen an der laryngalen Mäusechleimhaut als Folge endogener und exogener Faktoren.