title: Syndrome of inappropriate antidiuretic hormone secretion in neonates with pneumothorax or atelectasis.
abstract: Nine episodes of the syndrome of inappropriate antidiuretic hormone secretion occurred in five newborn infants following atelectasis or pneumothorax. All infants had pre-existing lung disease and were being treated with positive pressure ventilation. The mean interval between acute atelectasis or pneumothorax and the development of diagnostic hyponatremia, hypo-osmolal serum, hyperosmolal urine, and oliguria was 13.4 hours. Fluid restriction and removal of the triggering event resulted in resolution of the abnormalities within 1.5 to 4 days. Infants who develop atelectasis or pneumothorax should be evaluated for the subsequent occurrence of SIADH; the administration of a water load to them may result in dilutional hyponatremia, for which fluid restriction, not sodium infusion, is the proper therapy.
mesh_terms: D000208:Acute Disease; D006801:Humans; D007231:Infant, Newborn; D007232:Infant, Newborn, Diseases; D009994:Osmolar Concentration; D011030:Pneumothorax / Q000150:complications* / Q000378:metabolism; D001261:Pulmonary Atelectasis / Q000150:complications* / Q000378:metabolism; D012964:Sodium / Q000378:metabolism; D013577:Syndrome; D014667:Vasopressins / Q000378:metabolism*
chemical_list: D014667:Vasopressins; D012964:Sodium