[Wound healing in old age (experimental studies on rats) (author's transl)].
Autoradiographic studies on wound healing after experimental myocardial infarction in rats aged 6 weeks, 5 and 21 months gave the following results: 1. The interval between damage, DNA-replication and mitotic activity of the cells is age-dependent. 2. Age does not influence the capacity of the connective-tissue cells to synthesize tropocollagen. However, the number of synthesizing fibroblasts is reduced. 3. The collagen changes occuring during wound healing are not of primary, but of secondary nature; they take place if the mucopolysaccharide content is reduced. As a result, there is a decrease in the ground-substance synthesis in ageing granulation tissue. In cicatricial tissue the content of amorphous ground-substance remains greatly constant. 4. Consequently, the ageing of the collagen is governed by a biologically regulated process whose control mechanism is inherent in the cells.
D000367:Age Factors; D000375:Aging; D000818:Animals; D001345:Autoradiography; D003094:Collagen / Q000096:biosynthesis; D003239:Connective Tissue Cells; D004261:DNA Replication; D008297:Male; D008938:Mitosis; D009203:Myocardial Infarction / Q000503:physiopathology; D051381:Rats; D014945:Wound Healing
D003094:Collagen
Die Wundheilung im Alter. (Experimentelle Untersuchungen an Ratten).