title: Inhibition of gastric electrical and mechanical activity by intraduodenal agents in pigs and the effects of vagotomy.
abstract: Miniature pigs were chronically implanted with gastric electrodes, strain gauge devices allowing the measurement of circular contractions in the antrum and body of the stomach, and with a duodenal catheter through which duodenal infusions were administered. Inhibition of gastric motility by intraduodenal agents was measured before and after truncal vagotomy in conscious animals 20 min after feeding of a normal meal. The agents infused in the duodenum (10 ml/min, 4 min), were: HCl 75 mEq/l(A), glucose 100 g/l(G), olive oil 10% pH 7(L), amino acids (AA) and saline. Before vagotomy, motor activity during the first 5 min was inhibited 50-80% with respect to basal levels; the duration of action was G No. L greater than A; AA had very little effect, and saline no effect. Inhibition was on the whole similar in the antrum and gastric body. After vagotomy, the inhibitory effect of A was reduced from 80 to 20% in the antrum, and completely suppressed in the gastric body. Inhibitory effects of G and L were completely suppressed.
mesh_terms: D000596:Amino Acids / Q000008:administration & dosage / Q000494:pharmacology*; D000818:Animals; D004041:Dietary Fats / Q000008:administration & dosage; D004386:Duodenum; D005260:Female; D005769:Gastrointestinal Motility / Q000187:drug effects*; D005947:Glucose / Q000008:administration & dosage / Q000494:pharmacology*; D006168:Guinea Pigs; D006851:Hydrochloric Acid / Q000008:administration & dosage / Q000494:pharmacology*; D008297:Male; D011706:Pyloric Antrum / Q000187:drug effects; D013270:Stomach / Q000187:drug effects*; D014628:Vagotomy
chemical_list: D000596:Amino Acids; D004041:Dietary Fats; D005947:Glucose; D006851:Hydrochloric Acid