Topical instillation of doxorubicin hydrochloride in the treatment of recurring superficial transitional cell carcinoma of the bladder.
Thirteen patients with recurring stage A transitional cell carcinoma of the bladder were treated with monthly bladder instillations of doxorubicin hydrochloride. Follow-up at 3-month intervals has shown excellent control of tumor recurrence with complete remissions for up to 21 months in 2 patients. The median for remission in 8 of 13 patients has been 10 months. Two patients with bladder papillomatosis were treated successfully by the same method.
D000287:Administration, Topical; D002295:Carcinoma, Transitional Cell / Q000188:drug therapy*; D055598:Chemical Phenomena; D002621:Chemistry; D004317:Doxorubicin / Q000008:administration & dosage* / Q000627:therapeutic use; D006801:Humans; D010212:Papilloma / Q000188:drug therapy; D012008:Recurrence; D012075:Remission, Spontaneous; D001749:Urinary Bladder Neoplasms / Q000188:drug therapy*
D004317:Doxorubicin