title: Induction of microcycle sporulation in Bacillus brevis spp. AG4 by amethopterin.
abstract: Addition of amethopterin to medium before inoculation inhibited DNA synthesis and induced microcycle sporogenesis in Bacillus brevis spp. AG4. Synthesis of RNA and proteins occurred at a considerably reduced rate.
mesh_terms: D001407:Bacillus / Q000187:drug effects* / Q000502:physiology; D001426:Bacterial Proteins / Q000096:biosynthesis; D004269:DNA, Bacterial / Q000096:biosynthesis; D008727:Methotrexate / Q000494:pharmacology*; D012329:RNA, Bacterial / Q000096:biosynthesis; D013171:Spores, Bacterial
chemical_list: D001426:Bacterial Proteins; D004269:DNA, Bacterial; D012329:RNA, Bacterial; D008727:Methotrexate