title: Operant conditioning of the EEG in two patients with epilepsy: methodologic and clinical considerations.
abstract: Methodologic and clinical considerations are discussed in sensorimotor rhythm (SMR) biofeedback research on two dissimilar but severe epileptic males. The first case, an akinetic epileptic who prior to feedback training experienced 80-100 clinical seizures every 10 hours, showed considerable seizure reduction after 6 months of SMR and epileptiform training. A number of methodologic and instrumentation advances were pioneered with the akinetic patient: (1) development of and ultra-sharp band-pass filter; (2) use of epileptiform inhibit and feedback circuitry; (3) use of monetary rewards as additional incentive; (4) use of correlational analysis for evaluation of acquisition in the major dependent variables and; (5) use of noncontingent feedback and reinforcement as control techniques. The second case, a psychomotor epileptic, also showed therapeutic benefit from SMR training. Clinical information regarding the effect of anticonvulsant medications on the course and therapeutic outcome of SMR training are described. In conjunction with operant conditioning of 12 Hz activity, corresponding changes for other EEG parameters are examined.
mesh_terms: D000293:Adolescent; D000328:Adult; D000927:Anticonvulsants / Q000097:blood; D001676:Biofeedback, Psychology; D003216:Conditioning, Operant; D004569:Electroencephalography; D004827:Epilepsy / Q000188:drug therapy / Q000503:physiopathology / Q000628:therapy*; D004833:Epilepsy, Temporal Lobe / Q000628:therapy; D006801:Humans; D008297:Male; D008722:Methods; D009044:Motor Cortex / Q000503:physiopathology; D010672:Phenytoin / Q000008:administration & dosage; D011324:Primidone / Q000008:administration & dosage; D013003:Somatosensory Cortex / Q000503:physiopathology
chemical_list: D000927:Anticonvulsants; D011324:Primidone; D010672:Phenytoin