The effects of some anticholinergic compounds on the rabbit ureter.
Atropine, emeprone, and PR 197--a new anticholinergic compound--were examined for their possible effects on the rabbit ureter in situ. Ureteral pressure, recorded at two levels simultaneously, and intravesical pressure were studied. The effects of the substances were recorded in both normal (unobstructed) and obstructed ureters. It was found that all the substances, but especially PR 197, produced a fall in the basic intra-ureteral pressure, which was most pronounced in animals with obstructed ureters. PR 197 also temporarily abolished the ureteral peristalsis, while atropine and emeprone did not have this effect.
D000818:Animals; D001285:Atropine / Q000494:pharmacology; D004629:Emepronium / Q000494:pharmacology; D009119:Muscle Contraction / Q000187:drug effects; D010276:Parasympatholytics / Q000494:pharmacology*; D011312:Pressure; D011817:Rabbits; D014513:Ureter / Q000187:drug effects* / Q000502:physiology
D010276:Parasympatholytics; D004629:Emepronium; D001285:Atropine