title: Continued studies on the adjuvancy effect of natural and synthetic double-stranded RNA preparations with inactivated Newcastle disease vaccines in fowls.
abstract: The adjuvant effect of the natural ds-RNA, BRL 5907, with inactivated Newcastle disease vaccines was confirmed using different oil-based formulations and could be given either as single injections or separately at adjacent sites. A minimum dose level of 0-04 mg BRL 5907 per bird was required for a significant enhancement of antibody levels following vaccination. While the synthetic ds-RNA Poly IC gave a similar response to that observed with BRL 5907, no significant effects could be detected with two other natural ds-RNA materials.
mesh_terms: D000276:Adjuvants, Immunologic / Q000008:administration & dosage; D000818:Animals; D002645:Chickens / Q000276:immunology*; D006386:Hemagglutination Tests; D009521:Newcastle Disease / Q000517:prevention & control; D009522:Newcastle disease virus / Q000276:immunology*; D009821:Oils / Q000008:administration & dosage; D011061:Poly A / Q000008:administration & dosage; D011070:Poly I-C / Q000008:administration & dosage; D011072:Poly U / Q000008:administration & dosage; D011119:Polynucleotides / Q000008:administration & dosage; D012313:RNA / Q000008:administration & dosage; D014765:Viral Vaccines / Q000008:administration & dosage*
chemical_list: D000276:Adjuvants, Immunologic; D009821:Oils; D011119:Polynucleotides; D014765:Viral Vaccines; D011061:Poly A; D011072:Poly U; D012313:RNA; D011070:Poly I-C