title: The effect of synovial tissue on the breakdown of articular cartilage in organ culture.
abstract: Living (pig) cartilage in contact with synovium lost both proteoglycan and collagen and sometimes became reduced to a mass of fibroblast-like chondrocytes without matrix; dead cartilage lost proteoglycan but less collagen. Similar changes appeared in living cartilage grown at a distance from the synovium but in the same dish; dead cartilage was unaffected.
  
  
  CONCLUSIONS
  the synovium has a) a direct, presumably enzymatic action on cartilage matrix and b) an indirect effect mediated through the chondrocytes.
mesh_terms: D000818:Animals; D002358:Cartilage, Articular / Q000378:metabolism* / Q000648:ultrastructure; D002450:Cell Communication; D002469:Cell Separation; D002470:Cell Survival; D003094:Collagen / Q000378:metabolism; D009924:Organ Culture Techniques; D011509:Proteoglycans / Q000378:metabolism; D013552:Swine; D013583:Synovial Membrane / Q000378:metabolism* / Q000648:ultrastructure
chemical_list: D011509:Proteoglycans; D003094:Collagen