Experimental radiation synovectomy by 165Dy ferric hydroxide macroaggregate.
The short half-life beta emitter 165Dy coprecipitated as a macroaggregate with ferric hydroxide (FHMA) has been shown to destroy knee synovium in the antigen-induced arthritic rabbit. Using 153Gd as a gamma tracer for leakage studies revealed that the leakage of this system from rabbit knee joints never exceeded 1.2% over 24 hours. This is such less than the leakage rates reported from any human studies or our rabbit studies using 198Au.
D000818:Animals; D001168:Arthritis / Q000532:radiotherapy*; D001169:Arthritis, Experimental / Q000532:radiotherapy*; D001172:Arthritis, Rheumatoid / Q000473:pathology / Q000532:radiotherapy; D004307:Dose-Response Relationship, Radiation; D004419:Dysprosium / Q000378:metabolism / Q000627:therapeutic use*; D011817:Rabbits; D011868:Radioisotopes / Q000378:metabolism / Q000627:therapeutic use*; D013582:Synovial Fluid / Q000528:radiation effects; D013583:Synovial Membrane / Q000473:pathology / Q000528:radiation effects*; D014018:Tissue Distribution
D011868:Radioisotopes; D004419:Dysprosium