[3H]Thymidine labeling of dermal endothelial cells in scleroderma.
The purpose of this study was to estimate [3H] thymidine labeling of endothelial cells of skin capillaries in localized scleroderma (LS) and systemic scleroderma (SS). Skin specimens from 14 patients with SS, 5 with LS, and 9 matched controls were studied by in vitro autoradiography. Capillaries from patients with SS showed a statistically significant increase in endothelial cell labeling when compared to vessels from controls (p less than 0.0005).
D000328:Adult; D001345:Autoradiography; D002196:Capillaries / Q000378:metabolism / Q000473:pathology; D004727:Endothelium / Q000378:metabolism / Q000473:pathology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D012594:Scleroderma, Localized / Q000378:metabolism* / Q000473:pathology; D012595:Scleroderma, Systemic / Q000378:metabolism* / Q000473:pathology; D012867:Skin / Q000098:blood supply* / Q000473:pathology; D013936:Thymidine / Q000378:metabolism*; D014316:Tritium / Q000378:metabolism*
D014316:Tritium; D013936:Thymidine