[Action of androgens and one anti-androgen on the genital ducts of young discoglosses. Early development of seminal vesicles and inhibition of mullerian ducts (author's transl)].
Young Discoglossus pictus Otth (Amphibian, Anura) received either male hormone (testosterone or testosterone propionate) or the anti-steroid anti-androgen cyproterone acetate. The male hormone had a masculinizing effect on the genital tract when observed four months later and, paradoxically, the anti-androgen had the same effect: -- Hypertrophy of the posterior segment of the Wolffian ducts yields seminal vesicles, whose wall is covered with a flat epithelium after androgen treatment. Cyproterone acetate treatment, however, results in the cytological differentiation of this epithelium. -- Müllerian ducts persist in a vestigial form. In this respect, the inhibitory action of cyproterone acetate is stronger than that of the male hormone.
D000663:Amphibians / Q000196:embryology*; D000818:Animals; D003534:Cyproterone / Q000494:pharmacology*; D005260:Female; D008297:Male; D009095:Mullerian Ducts / Q000187:drug effects; D012733:Sex Differentiation / Q000187:drug effects*; D013739:Testosterone / Q000494:pharmacology*; D014928:Wolffian Ducts / Q000187:drug effects
D013739:Testosterone; D003534:Cyproterone
Action d'androgènes et d'un antiandrogène sur le tractus génital de discoglosses juvéniles. Développement précoce des vésicules séminales et inhibition des ébauches mullériennes.