Effect of the elimination of suppressor cells on the development of DNCB contact sensitivity in guinea-pig.
The effect of suppressor cells on the formation of effector cells was studied by comparing the development of DNCB contact sensitivity in cyclophosphamide-treated (suppressor cells eliminated) and non-treated (suppressor cells present) guinea-pigs. From experiments in four different models of generation of effector cells the following conclusions are drawn: (1) impulses activating the formation of effector cells also activate suppressor cells; (2) under conditions of conventional immunization, suppressor cells are activated later than effector cells; (3) elimination of suppressor cells results in an increase in the intensity and duration of specific skin reactions.
D000818:Animals; D003520:Cyclophosphamide / Q000494:pharmacology*; D003877:Dermatitis, Contact / Q000276:immunology*; D004137:Dinitrochlorobenzene / Q000276:immunology*; D006168:Guinea Pigs; D007114:Immunization; D007165:Immunosuppression Therapy; D008214:Lymphocytes / Q000276:immunology; D009578:Nitrobenzenes / Q000276:immunology*
D004137:Dinitrochlorobenzene; D009578:Nitrobenzenes; D003520:Cyclophosphamide