Combined radiotherapy and Corynebacterium parvum treatment of a murine fibrosarcoma.
A single dose of Corynebacterium parvum (Cp) at 70 microgram, 175 microgram or 350 microgram was effective in suppressing the growth of a subcutaneous fibrosarcoma and occasionally in inducing complete regression and in prolonging the survival time of C3H/HeJ tumor-bearing mice. A single exposure of x rays at 2,000 rads induced some complete regression, but a higher number of complete regressions was induced by combined x-ray and Cp treatment. In the combined x-ray and Cp treatment, Cp given on the same day immediately after x irradiation was best. When 70 microgram of Cp was given a few days before x rays, the intravenous and intraperitoneal routes were better than the intratumor route of injection.
D000818:Animals; D005354:Fibrosarcoma / Q000139:chemically induced / Q000532:radiotherapy / Q000628:therapy*; D007274:Injections, Intraperitoneal; D007275:Injections, Intravenous; D008297:Male; D008748:Methylcholanthrene; D051379:Mice; D008809:Mice, Inbred C3H; D009374:Neoplasms, Experimental / Q000532:radiotherapy / Q000628:therapy; D011425:Propionibacterium acnes / Q000276:immunology*; D013997:Time Factors
D008748:Methylcholanthrene