Fibrin-bound tumour cells on a sclerosed mitral valve.
The association of fibrin and tumour cells on a sclerosed mitral valve in a 62-year-old woman is described. This was the first indication of malignant disease but bilateral ovarian cancer was proved two months later. ino further tumour deposits have been found in fifteen months. The tumour deposit on the valve was most likely a metastasis but primary heart valve sarcoma has not been positively excluded. If the lesion was a secondary deposit this has possible implications for the role of fibrin in metastasis in humans.
D005260:Female; D005337:Fibrin / Q000502:physiology*; D006338:Heart Neoplasms / Q000473:pathology; D006349:Heart Valve Diseases / Q000150:complications* / Q000473:pathology; D006801:Humans; D008875:Middle Aged; D008943:Mitral Valve / Q000473:pathology*; D009362:Neoplasm Metastasis; D009360:Neoplastic Cells, Circulating; D010051:Ovarian Neoplasms / Q000150:complications* / Q000473:pathology; D010053:Ovary / Q000473:pathology; D012509:Sarcoma; D012598:Sclerosis
D005337:Fibrin