Central aromatization of testosterone in testicular feminized mice.
Aromatization of testosterone was examined in hypothalamic and cerebral cortex tissues from 32 mice--10 normal males, 10 normal females, 2 carrying the testicular feminized gene (Tfm) and 10 Tfm with the modifying (Ohv) gene. Total aromatization was 1.5 times greater in normal males than females. In both forms of Tfm, conversions were equal and similar to normal females.
D013734:Androgen-Insensitivity Syndrome / Q000235:genetics / Q000378:metabolism*; D000818:Animals; D002540:Cerebral Cortex / Q000378:metabolism; D004967:Estrogens / Q000096:biosynthesis / Q000235:genetics; D005260:Female; D005838:Genotype; D007031:Hypothalamus / Q000378:metabolism; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C / Q000235:genetics; D008815:Mice, Inbred Strains / Q000235:genetics; D013739:Testosterone / Q000235:genetics / Q000378:metabolism*
D004967:Estrogens; D013739:Testosterone