[Progress in the differential diagnosis of myocardial infarction by determining isoenzyme CK-MB with inhibitory antibodies (author's transl)].
Sensitivity and value of the quantitative measurement of the isoenzyme creatine kinase-MB by means inhibitory antibodies were studied in a number of experiments. The results indicate that concentrations of more than 3 U/1 are abnormal: they were found only in patients with myocardial cell damage but not after intramuscular injection or physical exercise. Determining CK-MB apparently offers a better way of assessing low or moderate increases of total CK activity than, e.g., the CK/GOT ratio. The method should therefore be introduced into clinical diagnosis. But the question of whether CK-MB measurement can differentiate between myocardial infarction and reversible myocardial cell damage remains unanswered: it is not 100% specific for myocardial infarction.
D000293:Adolescent; D000328:Adult; D000368:Aged; D000906:Antibodies; D004796:Clinical Enzyme Tests; D003402:Creatine Kinase / Q000097:blood*; D005260:Female; D006801:Humans; D007273:Injections, Intramuscular; D007527:Isoenzymes / Q000097:blood*; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000175:diagnosis* / Q000201:enzymology; D009206:Myocardium / Q000201:enzymology; D005082:Physical Exertion
D000906:Antibodies; D007527:Isoenzymes; D003402:Creatine Kinase
Fortschritte in der Differentialdiagnose des Herzinfarkts. Bestimmung des CK-Isoenzym CK-MB mit inhibierenden Antikörpern.