Induction of hepatic aryl hydrocarbon hydroxylase in C57BL mice by ionizing radiation.
Inbred strains of C57BL mice were exposed to either 100, 500, or 1000 rads of whole-body irradiation. Another group of mice were given injections of 3-methylcholanthrene only, and a control group had no treatment. Forty-eight hr after treatment, the animals were killed and hepatic aryl hydrocarbon hydroxylase (AHH) activity was measured by spectrophotofluorometer. A comparison of hepatic AHH activity in treated and nontreated groups of mice showed that each treated group had a significantly increased AHH induction compared with the control group. Although radiation appeared to have a dose-related effect on AHH induction, the increase with dose level was not statistically significant.
D000818:Animals; D001189:Aryl Hydrocarbon Hydroxylases / Q000096:biosynthesis*; D004307:Dose-Response Relationship, Radiation; D004790:Enzyme Induction / Q000187:drug effects / Q000528:radiation effects; D005260:Female; D008099:Liver / Q000187:drug effects / Q000201:enzymology / Q000528:radiation effects*; D008297:Male; D008748:Methylcholanthrene / Q000494:pharmacology; D051379:Mice; D008810:Mice, Inbred C57BL; D014965:X-Rays
D008748:Methylcholanthrene; D001189:Aryl Hydrocarbon Hydroxylases