[Effect of chenic acid on bile lipid composition and on metabolism of bile acids in lithiasis patients].
Gallbladder bile unsaturated with cholesterol is a prerequisite for gallstone dissolution. Chenodeoxycholic (chenic) acid ingestion by patients with gallstones induces saturated bile to become unsaturated. Additionally, chenic acid becomes the predominant bile acid in bile and the chenic acid and total bile acid pools increase in a majority of such patients. Most importantly, the hourly secretion of cholesterol decreases during chenic therapy such that the cholesterol to bile acid ratio in bile is significantly lower and bile becomes unsaturated with cholesterol. Preliminary evidence suggests that the mechanism of action of chenic acid may relate to a suppression of the rate limiting hepatic enzyme for cholesterol synthesis, HMGCoA reductase.
D001646:Bile / Q000187:drug effects / Q000378:metabolism*; D001647:Bile Acids and Salts / Q000378:metabolism; D002635:Chenodeoxycholic Acid / Q000494:pharmacology*; D002769:Cholelithiasis / Q000378:metabolism*; D002784:Cholesterol / Q000378:metabolism; D005215:Fasting; D006801:Humans; D050356:Lipid Metabolism
D001647:Bile Acids and Salts; D002635:Chenodeoxycholic Acid; D002784:Cholesterol
Effetto dell'acido chenico sulla composizione lipidica biliare e sul metabolismo degli acidi biliari nei pazienti litiasici.