[Lymphocyte reaction in meningitis to the addition of anti-inflammatory preparations to the cell culture].
Microbial stimulation of lymphocytes of patients suffering from meningococcus infection increased primarily under the effect of antiphlogistic preparations in vitro; more rarely it was inhibited. In experiments with lymphocytes of the patients this increase was more than 5-fold, and with those of healthy donors -- not more than 2-fold. With a low initial lymphocyte reactivity the intersification of specific stimulation with the preparations was more pronounced than with the average and the high one. There were differences in the action of pyrasolone derivatives and hydrocortisone -- the latter inhibited this reaction more frequently than amidopyrinum and butadion.
D000632:Aminopyrine / Q000494:pharmacology; D000893:Anti-Inflammatory Agents / Q000494:pharmacology*; D000942:Antigens, Bacterial; D002478:Cells, Cultured; D006801:Humans; D006854:Hydrocortisone / Q000494:pharmacology; D008213:Lymphocyte Activation / Q000187:drug effects; D008214:Lymphocytes / Q000187:drug effects* / Q000276:immunology; D008581:Meningitis / Q000276:immunology*; D008589:Meningococcal Infections / Q000276:immunology; D009698:Nucleoproteins / Q000276:immunology; D010653:Phenylbutazone / Q000494:pharmacology; D013291:Streptococcus / Q000276:immunology
D000893:Anti-Inflammatory Agents; D000942:Antigens, Bacterial; D009698:Nucleoproteins; D000632:Aminopyrine; D010653:Phenylbutazone; D006854:Hydrocortisone
Reaktsiia limfotsitov bol'nykh meningitom na dobavlenie v kul'turu kletok protivovospalitel'nykh preparatov.