Association of polymyalgia rheumatica and giant-cell arteritis with HLA-B8.
Histocompatibility antigens were determined in 30 patients with temporal arteritis, 27 patients with polymyalgia rheumatica, and 216 normal blood donors. HLA-B8 was significantly more common in patients with polymyalgia rheumatica (59%) and temporal arteritis (50%) than in the controls (27%). The findings of HLA-A10 in 26% of the patients with polymyalgia rheumatica compared with only 10% of the controls may be associated with the suggested immunological pathogenesis of the condition.
D005260:Female; D013700:Giant Cell Arteritis / Q000150:complications / Q000235:genetics / Q000276:immunology*; D006680:HLA Antigens / Q000032:analysis*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011111:Polymyalgia Rheumatica / Q000150:complications / Q000235:genetics / Q000276:immunology*
D006680:HLA Antigens