Effects of intraventricular 6-hydroxydopamine on cerebrovascular CO2 reactivity in anesthetized rats.
Regional cerebral blood flow was measured by the 14C-ethanol technique in anesthetized rats before and after intraventricular injection of 6-hydroxydopamine. This treatment reduced the fluorescence of the central noradrenaline and dopamine nerve terminals, as well as of the perivascular nerve terminals in cerebral vessels. The administration of 6-hydroxydopamine had no significant effect on cerebral blood flow at normocapnia. The cerebrovascular reactivity to hypercapnia was significantly increased in the 6-hydroxydopamine treated animals. The results indicate an involvement of central catecholamine pathways in the cerebrovascular reactivity to hypercapnia.
D000818:Animals; D002245:Carbon Dioxide / Q000097:blood*; D002395:Catecholamines / Q000502:physiology; D002560:Cerebrovascular Circulation / Q000187:drug effects*; D000431:Ethanol; D006892:Hydroxydopamines / Q000008:administration & dosage / Q000494:pharmacology*; D006935:Hypercapnia / Q000503:physiopathology; D007276:Injections, Intraventricular; D008297:Male; D010313:Partial Pressure; D051381:Rats
D002395:Catecholamines; D006892:Hydroxydopamines; D002245:Carbon Dioxide; D000431:Ethanol