[Effect of aminazin, phenobarbital and their combination on the activity of the liver hydroxylase system and on their individual pharmacological effects].
Administration of phenobarbital to male-rats for 4 days induced the appearance of P-450 cytochrome in the liver and intensified the activity of the hydroxylase system, more specifically with respect to hexobarbital than to amidopyrine. The cataleptic effect of chlorpromazine was then running low. A 4-day long administration of chlorpromazine failed to increase the P-450 cytochrome content, but did change the hydroxylating activity of the microsomes in favour of the amidopyrine metabolism. With joint introduction of chlorpromazine and phenobarbital the intensity of the amidopyrine hydroxylation increased to a greater extent.
D000632:Aminopyrine; D000818:Animals; D002746:Chlorpromazine / Q000494:pharmacology*; D003577:Cytochrome P-450 Enzyme System / Q000096:biosynthesis*; D004357:Drug Synergism; D004790:Enzyme Induction / Q000187:drug effects; D006591:Hexobarbital; D006900:Hydroxylation; D008297:Male; D008862:Microsomes, Liver / Q000187:drug effects / Q000201:enzymology*; D010634:Phenobarbital / Q000494:pharmacology*; D051381:Rats
D000632:Aminopyrine; D003577:Cytochrome P-450 Enzyme System; D006591:Hexobarbital; D002746:Chlorpromazine; D010634:Phenobarbital
Vliianie aminazina, fenobarbitala i ikh sochetaniia na aktivnost' gidroksilaznoĭ sistemy pecheni i na farmakologicheskiĭ éffekt etikh preparatov.