[Effect of insulin and insulin deficiency on the activity of hexokinase, malate dehydrogenase, lactate dehydrogenase and its isoenzyme composition in the smooth muscle of the rabbit stomach].
Decrease in the activity of hexokinase was found in soluble fraction of stomach smooth muscles of rabbits with alloxane diabetes. Administration of insulin into intact rabbits led to distinct decrease in the activity of lactate and malate dehydrogenases in cells of the stomach fundal part. In smooth muscles of rabbits with alloxane diabetes pyruvate was formed from lactate at a higher rate (increase in content of LDH1 and LDH2) and after administration of insulin into the animals--lactate was formed from pyruvate at an increased rate.
D000818:Animals; D003921:Diabetes Mellitus, Experimental / Q000201:enzymology*; D006593:Hexokinase / Q000378:metabolism*; D007328:Insulin / Q000494:pharmacology*; D007527:Isoenzymes; D007770:L-Lactate Dehydrogenase / Q000378:metabolism*; D008291:Malate Dehydrogenase / Q000378:metabolism*; D009130:Muscle, Smooth / Q000201:enzymology*; D011708:Pylorus / Q000201:enzymology; D011817:Rabbits; D013270:Stomach / Q000201:enzymology
D007328:Insulin; D007527:Isoenzymes; D007770:L-Lactate Dehydrogenase; D008291:Malate Dehydrogenase; D006593:Hexokinase
Vliianie insulina i insulinovoĭ nedostatochnosti na aktivnost' geksokinazy, malate degidrogenazy, laktatdegidrogenazy i ee izofermentnyĭ sostav v gladkikh myshtsakh zheludka krolika.