title: Enhanced allergic tissue injury in Goodpasture's syndrome by intercurrent bacterial infection.
abstract: Studies of 16 relapses in seven patients receiving treatment for Goodpasture's syndrome showed that intercurrent bacterial infection seemed to be the precipitating event in 13 cases, whereas a rising antibody titre to glomerular basement membrane was responsible in only one. This association between infection and relapse in Goodpasture's syndrome has several implications for the pathogenesis of antibody-mediated tissue damage, and, clearly, more experiments are needed. Whatever the explanation, however, prevention and early diagnosis and treatment of infection in anti-GBM disease are important.
mesh_terms: D000293:Adolescent; D000328:Adult; D019867:Anti-Glomerular Basement Membrane Disease / Q000150:complications* / Q000276:immunology; D001323:Autoantibodies / Q000032:analysis; D001424:Bacterial Infections / Q000150:complications* / Q000276:immunology; D001485:Basement Membrane / Q000276:immunology; D005260:Female; D006801:Humans; D007678:Kidney Glomerulus / Q000276:immunology; D008168:Lung / Q000276:immunology; D008297:Male; D008875:Middle Aged; D012008:Recurrence
chemical_list: D001323:Autoantibodies