title: Topical mechlorethamine. Cutaneous changes in patients with mycosis fungoides after its administration.
abstract: Six patients with mycosis fungoides were treated with topical mechlorethamine hydrochloride for periods of two to four years. Clinical and histological studies for radiomimetic and radiodermatitis-like effects failed to demonstrate any abnormalities. The only observed changes were generalized hyperpigmentation of the skin and melanin-containing melanophages in the papillary dermis. We consider that the long-term use of topical mechlorethamine may be a safe form of therapy, but that a continuous indefinite follow-up of patients on this medication should be mandatory.
mesh_terms: D000287:Administration, Topical; D001706:Biopsy; D004247:DNA; D003877:Dermatitis, Contact / Q000209:etiology; D006801:Humans; D008466:Mechlorethamine / Q000008:administration & dosage* / Q000009:adverse effects / Q000494:pharmacology / Q000627:therapeutic use; D009182:Mycosis Fungoides / Q000188:drug therapy*; D010859:Pigmentation Disorders / Q000139:chemically induced; D012867:Skin / Q000187:drug effects / Q000473:pathology; D012878:Skin Neoplasms / Q000188:drug therapy*; D012880:Skin Pigmentation / Q000187:drug effects
chemical_list: D008466:Mechlorethamine; D004247:DNA