Technetium-99m stannous citrate brain-tumor uptake in mice: concise communication.
The pharmacodynamics of technetium-99m stannous citrate were studies in Yale-Swiss mice bearing a sarcoma-like transplantable brain tumor, and the renal kinetics were determined in normal mice. Using a rating system based on tumor uptake and tumor-to-brain, tumor-to-blood, and tumor-to-skin ratios, the data obtained with this compound were compared with similar data obtained previously in the same model with Tc-99m Fe-(ascorbic acid), Tc-99m Fe-(ascorbic acid)-DTPA, Tc-99m Sn-DTPA, [99mTc] pertechnetate, and [99mTc] pertechnetate with perchlorate predose. Technetium-99m stannous citrate does not appear to achieve tumor localization by a mode different from these other Tc-99m-labeled compounds, nor does it show any potential advantage as a scanning agent in the tumor model.
D000818:Animals; D001932:Brain Neoplasms / Q000175:diagnosis*; D002951:Citrates; D051379:Mice; D009368:Neoplasm Transplantation; D009374:Neoplasms, Experimental / Q000175:diagnosis; D011877:Radionuclide Imaging; D012509:Sarcoma / Q000175:diagnosis*; D013667:Technetium; D014001:Tin
D002951:Citrates; D013667:Technetium; D014001:Tin