Comparative inhibitory effects of 3-quinuclidinyl benzilate (QNB) and atropine on amylase release from rat pancreas.
1 Secrection of amylase from rat pancreas stimualted by urecholine was studied in relation to its inhibition by atropine and 3-quinuclidinyl benzilate (QNB). 2 Urecholine-induced secretion was completely abolished by atropine at 10(-6)M and QNB at 10(-8)M. Significant inhibition could be detected at 10(-8)M atropine and 10(-10)M QNB. 3 The secretory response to pancreozymin was not blocked either by atropine or QNB. 4 The inhibitory effect of QNB remained for at least 90 min after its removal from the incubation medium. 5 It is concluded that QNB is 10 times more potent than atropine in inhibiting pancreatic amylase secretion induced by urecholine.
D000681:Amylases / Q000378:metabolism*; D000818:Animals; D001285:Atropine / Q000494:pharmacology*; D001561:Benzilates / Q000494:pharmacology*; D001626:Bethanechol Compounds / Q000494:pharmacology; D002766:Cholecystokinin / Q000494:pharmacology; D004247:DNA / Q000378:metabolism; D003864:Depression, Chemical; D066298:In Vitro Techniques; D008297:Male; D010179:Pancreas / Q000187:drug effects / Q000201:enzymology*; D011812:Quinuclidines / Q000494:pharmacology*; D051381:Rats
D001561:Benzilates; D001626:Bethanechol Compounds; D011812:Quinuclidines; D001285:Atropine; D004247:DNA; D002766:Cholecystokinin; D000681:Amylases