Corneal thickness after vitrectomy and infusion with dextran solution.
We studied with pachometry the degree of corneal endothelial decompensation in rabbits undergoing extracapsular lens extraction and vitrectomy. We used 3 different infusion solutions: (1) 0.9% sodium chloride; (2) 0.45% sodium chloride with 2.5% glucose; and (3) 0.45% sodium chloride, 2.5% glucose, and 2% dextran. Vitrectomy and vitreous replacement with the last solution demonstrated the least overall increase in corneal thickness. On the basis of these observations, dextran may be a useful colloid osmotic agent in intraocular irrigating fluids to control and decrease postoperative corneal edema.
D000818:Animals; D003315:Cornea / Q000473:pathology; D003316:Corneal Diseases / Q000517:prevention & control; D003318:Corneal Opacity / Q000517:prevention & control; D003911:Dextrans / Q000627:therapeutic use*; D004487:Edema / Q000517:prevention & control*; D004727:Endothelium / Q000473:pathology; D005947:Glucose / Q000627:therapeutic use; D007908:Lens, Crystalline / Q000601:surgery*; D011183:Postoperative Complications / Q000517:prevention & control*; D011817:Rabbits; D012965:Sodium Chloride / Q000627:therapeutic use; D014822:Vitreous Body / Q000601:surgery*
D003911:Dextrans; D012965:Sodium Chloride; D005947:Glucose