[Aspects of glycolipid metabolism in chronic renal insufficiency: interference of oral glucose administration during and after dialysis with changes induced by short dialyses with glucose free dialysate].
As part of some research into certain aspects of glycolipidic metabolism in chronic renal insufficiency, a study has been made of alterations in glycaemia, insulinaemia, free fatty acids and triglycerides during and following brief periods of dialysis by glucose-free bath in 26 subjects: within this group, 50 g of glucose were administered to 8 patients at the 2nd hour of dialysis and 100 g to another 8 at the end of therapy. The following findings were made during glucose-free dialysis: marked hypoglycaemia starting from the first hour until the end, marked increase in FFA and marked fall in TG upon the lipolytic action of heparin. In the post-dialysis period, immediate normalization in glycaemia, steady diminution in FFA and notable increase in TG as early as the 1st hour. Administration of glucose during dialysis prevents hypoglycaemia by altering FFA and TG behaviour in the post-dialysis period. Administration of glucose at the end leads to hyperglycaemia and hyperinsulinaemia with marked fall in FFA and TG. During dialysis, the phenomena observed depend on the action of heparin, acetate and the absence of glucose. This absence brings on hypoglycaemia with secondary glycogenolysis and-or neoglucogenesis during dialysis; in the post-dialysis period, hepatic neosynthesis of TG in the presence of normal glycaemic and insulinaemic values. Glucose per os determines hyperglycaemia and secondary hyperinsulinaemia with FFA esterification at the level of adipose tissue and a fall in serous TG.
D000284:Administration, Oral; D000328:Adult; D000368:Aged; D005230:Fatty Acids, Nonesterified / Q000378:metabolism; D005260:Female; D005947:Glucose / Q000008:administration & dosage*; D006017:Glycolipids / Q000378:metabolism*; D006801:Humans; D007676:Kidney Failure, Chronic / Q000378:metabolism* / Q000628:therapy; D008297:Male; D008875:Middle Aged; D006435:Renal Dialysis / Q000379:methods*; D013997:Time Factors; D014280:Triglycerides / Q000378:metabolism
D005230:Fatty Acids, Nonesterified; D006017:Glycolipids; D014280:Triglycerides; D005947:Glucose
Aspetti del metabolismo glicolipidico nell'insufficienza renale cronica: interferenza della somministrazione orale di glucosio durante e dopa dialisi sulle modificazioni indotte da dialisi brevi con bagno senza glucosio.