Alcohol-discrimination in gerbils: interactions with bemegride, DH-524, Amphetamine, and delta9-THC.
Male gerbils were trained to discriminate the effects of an injection of alcohol (1.0, 1.5, and 2.0 g/kg) from the nondrug condition in a T-shaped maze. The formation of the discrimination was related to the training dose used, the high dose (2 g/kg) being the most rapidly discriminable condition. After having reached a criterion of performing 8 correct first-trial choices out of 10 consecutive training sessions the animals were tested for possible generalization or antagonism with bemegride, DH-524, d-amphetamine or delta9-THC. The results suggested that neither of these drugs substituted for alcohol, nor did the drugs reverse or antagonize the alcohol-discrimination, i.e. the gerbils choose the nondrug associated position of the T-maze after single injections of the test-drugs whereas combinations of alcohol and the test-drugs resulted in responding appropriate for the alcohol-(training)-condition.
D000818:Animals; D001534:Bemegride / Q000494:pharmacology*; D003913:Dextroamphetamine / Q000494:pharmacology*; D004192:Discrimination, Psychological / Q000187:drug effects*; D013759:Dronabinol / Q000494:pharmacology*; D004347:Drug Interactions; D000431:Ethanol / Q000494:pharmacology*; D005849:Gerbillinae; D007093:Imidazoles / Q000494:pharmacology*; D008297:Male; D010634:Phenobarbital / Q000494:pharmacology; D013997:Time Factors
D007093:Imidazoles; D000431:Ethanol; D001534:Bemegride; D013759:Dronabinol; D003913:Dextroamphetamine; D010634:Phenobarbital