X-ray analysis of sulfur-containing colchicine derivatives.
The crystal and molecular structures of deacetylthiocolchicine hydrochloride dihydrate and thiocolchicine hexahydrate were determined by X-ray diffraction. The replacement of oxygen by sulfur on the C ring methoxy group causes greater puckering of the troponoid ring. The conformation of one A ring methoxy group differs from that of colchicine derivatives that do not contain sulfur.
D055598:Chemical Phenomena; D002621:Chemistry; D003078:Colchicine / Q000031:analogs & derivatives* / Q000032:analysis; D008958:Models, Molecular; D008968:Molecular Conformation; D013455:Sulfur / Q000032:analysis; D014961:X-Ray Diffraction
D013455:Sulfur; D003078:Colchicine