Evaluation of drug formulations using LD50 testing in mice.
The LD50 values were utilized to assess the relative rate of absorption of two very poorly soluble drugs. Formulations of these drugs were studied by micronization; addition of surfactant, alkaline or buffering agents, and/or bile salts; coprecipitation; melt or fusion techniques; or granulation with hydrophilic agents. Differences in toxicities were demonstrated from formulations compared to pure drugs by the LD50 method. This study shows that the LD50 is a practical, rapid method of achieving comparative evaluations of drug formulations.
D000818:Animals; D001682:Biological Availability; D002626:Chemistry, Pharmaceutical; D004304:Dosage Forms; D004339:Drug Compounding; D007928:Lethal Dose 50; D051379:Mice; D004364:Pharmaceutical Preparations / Q000008:administration & dosage* / Q000378:metabolism; D014116:Toxicology
D004304:Dosage Forms; D004364:Pharmaceutical Preparations