[Leukocyte migration inhibition test in lupus erythematosus and dermatomyositis].
The Leucocyte-Migration-Inhibition-Test was performed to examine 10 patients with Systemic Lupus Erythematosus (SLE), 10 patients with Discoid Lupus Erythematosus (DLE) and 4 patients with Dermatomyositis for evidence of cell-mediated immunity to RNA, DNA, human muscle antigen and collagen human type I. Our results support, that cell-mediated immunity plays a pathogenic role in both diseases. Patients with SLE show a correlation between activity of disease, Leucocyte-Migration-Inhibition to DNA and DNA-binding-activity of serum. Muscle-antigen is an obvious relevant partner of reaction of cellular immunity in patients with Dermatomyositis.
D000906:Antibodies / Q000302:isolation & purification; D002464:Cell Migration Inhibition; D004247:DNA / Q000276:immunology; D003882:Dermatomyositis / Q000276:immunology*; D006801:Humans; D007111:Immunity, Cellular; D008180:Lupus Erythematosus, Systemic / Q000276:immunology*; D008214:Lymphocytes / Q000276:immunology; D012313:RNA / Q000276:immunology
D000906:Antibodies; D012313:RNA; D004247:DNA
Leukocytenmigrationshemmung bei Lupus erythematodes und Dermatomyositis.