Concentration of clonazepam in serum and cerebrospinal fluid of the sheep.
Following intravenous administration of clonazepam to sheep there was rapid equilibration of cerebrospinal fluid and unbound serum concentrations of the drug. The pharmacokinetics of clonazepam in sheep describe a 2-compartment model and the large volume of distribution suggests tissue binding of clonazepam. There was wide variation in serum concentration and at least 2 mg of clonazepam was necessary to attain the recommended therapeutic concentration.
D000818:Animals; D001570:Benzodiazepinones / Q000378:metabolism*; D002998:Clonazepam / Q000097:blood / Q000134:cerebrospinal fluid / Q000378:metabolism*; D012756:Sheep
D001570:Benzodiazepinones; D002998:Clonazepam