Inhibitory effect of taurine on decrease in the inotropic action of ouabain at high concentrations in isolated atria.
In vitro, taurine was shown to inhibit the decrease in the inotropic effect of ouabain at large doses in the normal and also low K+ medium in which this decrease in the inotropism of ouabain was facilitated. This inhibitory effect of taurine was, at least in part, due to the inhibition of the efflux of intracellular K+ in the isolated heart.
D000818:Animals; D002304:Cardiac Pacing, Artificial; D004347:Drug Interactions; D006168:Guinea Pigs; D066298:In Vitro Techniques; D008297:Male; D009200:Myocardial Contraction / Q000187:drug effects*; D009206:Myocardium / Q000378:metabolism; D010042:Ouabain / Q000494:pharmacology*; D011188:Potassium / Q000378:metabolism; D013654:Taurine / Q000494:pharmacology*
D013654:Taurine; D010042:Ouabain; D011188:Potassium