[Antigen Fyx: quantitative study of subjects FybFyx, FyaFyx and FyxFyx from two new families].
Two new families are described in which multiple examples of antigen Fyx are found in homo-and heterozygous states. The expression of the antigen is evaluated by conventional methods (agglutination scoring) and HD50 assays using a polybren-citrate autoanalyzer technique. Individuals from both families are tested in parallel with those from the family of the first known examples of homozygous FyxFyx described by Cedergren and Giles [2], and with 59 known FyaFyb and FybFyb controls. No consanguinity is found in the two families reported. Quantitative study of anti-Fyb absorption by red cells reveals that the expression of Fyb in individuals considered to be FybFyx is weaker than in FybFyb and even FyaFyb controls. HD50 assay data obtained in the control donors population seem to indicate that, in contrast to the admitted opinion, intermediate degrees of antigenic strength do exist between "normal" Fyb and Fyx the definition of which, based on quantitative criteria, remains unprecise. Using a new potent anti-Fy3 (AR), the expression of Fy3 displayed a slight and variable decrease in FyxFyx samples investigated.
D001789:Blood Group Antigens / Q000235:genetics*; D004375:Duffy Blood-Group System / Q000235:genetics*; D006579:Heterozygote; D006720:Homozygote; D006801:Humans; D010375:Pedigree
D001789:Blood Group Antigens; D004375:Duffy Blood-Group System
Antigène Fyx: etude quantitative chez les sujets FybFyx, FyaFyx et FyxFyx provenant de deux nouvelles familles.