The toxicity and antitumor activity of three individual fractions of lectins from Ricinus communis seeds.
Lectins from Ricinus communis seeds (RCL) have been resolved into three electrophoretically distinct fractions (alpha-RCL, beta-RCL, psi-RCL) by ion exchange chromatography on Watman CM-32 cellulose. The toxicity to mice and antitumor activity against murine lymphoma NK/Ly of pure fractions were compared. Optimal effect was achieved with alpha-RCL, Which possessed the lowest toxicity (1000 micron g/kg) and significant antitumor activity (63% inhibition of tumor growth).
D000818:Animals; D000970:Antineoplastic Agents / Q000627:therapeutic use* / Q000633:toxicity; D037102:Lectins / Q000008:administration & dosage / Q000627:therapeutic use* / Q000633:toxicity; D008223:Lymphoma / Q000188:drug therapy* / Q000473:pathology; D051379:Mice; D009374:Neoplasms, Experimental / Q000188:drug therapy / Q000473:pathology; D037121:Plant Lectins; D012639:Seeds; D013154:Spleen / Q000473:pathology
D000970:Antineoplastic Agents; D037102:Lectins; D037121:Plant Lectins