[Action of O-beta-diethylaminoethylhydroxylamine on bacteriophage T2].
A chemical modification of T2 phage DNA by O-beta-diethylaminoethylhydroxylamine was studied in situ. In the course of the reaction, cross-links between DNA and protein of the phage particle develop. The DNA-protein interaction contributes to the nucleophilic joining of hydroxylamine derivatives by C5-C6 double bond of 5-oxymethylycytosine which is a constituent of T2 phage DNA.
D003090:Coliphages / Q000187:drug effects*; D004279:DNA, Viral / Q000494:pharmacology; D004347:Drug Interactions; D006898:Hydroxylamines / Q000494:pharmacology*; D008854:Microscopy, Electron; D011485:Protein Binding / Q000187:drug effects; D012897:Slow Virus Diseases / Q000145:classification; D013696:Temperature; D013997:Time Factors
D004279:DNA, Viral; D006898:Hydroxylamines
Deistvie O-beta-diétilaminoétilgidroksilamina na bakteriofag T2.