Malakoplakia of kidney simulating renal neoplasm.
In a nine-year-old girl with renal hypertension and a urinary infection, angiographic studies of the left kidney suggested an intrarenal pheochromocytoma. After nephrectomy, the kidney was found to contain only a cystic lesion characterized by multiple small, friable excrescences. Under the light microscope these appeared to be formed by granulovacuolated macrophages. Electron microscopy showed intracytoplasmic inclusion identified as Michaelis-Gutmann bodies in various stages of formation. Images suggestive of degraded bacteria were also observed within phagolysosomes.
D002648:Child; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D006977:Hypertension, Renal / Q000150:complications; D007674:Kidney Diseases / Q000150:complications / Q000000981:diagnostic imaging* / Q000473:pathology; D007680:Kidney Neoplasms / Q000000981:diagnostic imaging*; D008247:Lysosomes / Q000648:ultrastructure; D008264:Macrophages / Q000648:ultrastructure; D008287:Malacoplakia / Q000150:complications / Q000000981:diagnostic imaging* / Q000473:pathology; D010673:Pheochromocytoma / Q000000981:diagnostic imaging; D011859:Radiography