[Some features of the side effects of antibiotics in bronchopulmonary diseases].
A total of 1838 cases treated with antibiotics were analyzed in a pulmonological clinic. The antibiotics were used because of acute pneumonia, exacerbated chronic pneumonia, active inflammatory processes in cases with infectious allergic bronchial asthma and other bronchopulmonary diseases. Levomycetin (21 per cent), benzylpenicillin (14 per cent), oletetrin, erythromycin, semi-synthetic penicillins, aminoglycosides and other antibiotics were used most often. The antibiotic side effects were registered in 1.4 per cent of the cases, the allergic complications being 4 times more frequent than toxico-metabolic complications. The main path for prevention of the antibiotic side effects was rational antibiotic therapy. The antibiotic choice should be guided by the following considerations: process localization, patient's age, causative agent species, its antibiotic sensitivity, antibiotic pharmacokinetic characteristics in the organism of the patient, character of the antibiotic side effects on the macroorganism.
D000208:Acute Disease; D000900:Anti-Bacterial Agents / Q000009:adverse effects* / Q000633:toxicity; D001249:Asthma / Q000188:drug therapy; D001982:Bronchial Diseases / Q000188:drug therapy*; D002908:Chronic Disease; D004305:Dose-Response Relationship, Drug; D004342:Drug Hypersensitivity / Q000175:diagnosis; D006801:Humans; D008171:Lung Diseases / Q000188:drug therapy*; D010406:Penicillins / Q000009:adverse effects; D011014:Pneumonia / Q000188:drug therapy
D000900:Anti-Bacterial Agents; D010406:Penicillins
Nekotorye storony pobochnogo deĭstviia antibiotikov u bol'nykh s bronkholegochnymi zabolevaniiami.