title: Mixed connective tissue disease--clinical and radiological aspects of 20 cases.
abstract: The clinical and radiological features of 20 cases of mixed connective tissue disease (MCTD), a newly defined disorder, are described. MCTD shares a number of abnormalities with other collagen diseases, notably diffuse systemic sclerosis and systemic lupus erythematosus. However, patients with MCTD have a specific circulating antibody to extractable nuclear antigen (ENA). Most of the cases described exhibited multi-system involvement with radiological changes in the skeleton, chest, and gastro-intestinal tract. Twelve of the 20 cases had an erosive arthritis. This finding has not been previously noted in the radiological literature.
mesh_terms: D000906:Antibodies / Q000032:analysis; D001842:Bone and Bones / Q000000981:diagnostic imaging; D003095:Collagen Diseases / Q000000981:diagnostic imaging* / Q000276:immunology; D005767:Gastrointestinal Diseases / Q000000981:diagnostic imaging; D006225:Hand / Q000000981:diagnostic imaging; D006801:Humans; D006976:Hypertension, Pulmonary / Q000000981:diagnostic imaging; D008171:Lung Diseases / Q000000981:diagnostic imaging; D011859:Radiography
chemical_list: D000906:Antibodies