Evaluation of intranasal zinc sulfate treatment on olfactory discrimination in rats.
The effects of intranasal syringing with 5% zinc sulfate were assessed in rats trained in a wind-tunnel olfactometer to detect the presence of an odor or to discriminate odors of graded intensities. The syringing produced a severe but brief interference in olfactory performance. Full recovery of detection performance occurred within 72 hr after treatment. Initial recovery of odor intensity discrimination occurred in 2-8 days and full recovery within 8-10 days. These results suggest that intranasal syringing with ZnSO4 is not an adequate control for the effects of anosmia produced by olfactory bulbectomy.
D000281:Administration, Intranasal; D000818:Animals; D003216:Conditioning, Operant; D004192:Discrimination, Psychological / Q000187:drug effects*; D008297:Male; D009812:Odorants; D000857:Olfaction Disorders / Q000139:chemically induced*; D009830:Olfactory Bulb / Q000502:physiology; D051381:Rats; D012119:Respiration / Q000187:drug effects; D012903:Smell / Q000187:drug effects*; D013431:Sulfates / Q000494:pharmacology; D013997:Time Factors; D014796:Visual Perception / Q000187:drug effects; D015032:Zinc / Q000008:administration & dosage* / Q000494:pharmacology / Q000506:poisoning
D013431:Sulfates; D015032:Zinc