title: Cholesterol gallstone dissolution rate accelerators I: Exploratory investigations.
abstract: Various compounds that might function as cholesterol gallstone dissolution accelerators were studied. The dissolution rates of cholesterol monohydrate pellets in synthetic bile (116 mM sodium cholate-32 mM lecithin) containing the agent at various concentration levels were determined. In the absence of any dissolution rate accelerator, the dissolution kinetics for cholesterol previously were found to be interfacial resistance controlled, and the rates were around 20 times less than the diffusion-controlled rates in the present experiments. Primary, secondary, and tertiary amines and quaternary ammonium compounds were effective accelerators. When the alkyl chain lengths were long enough and/or when the agent concentrations were high enough, the dissolution rates generally approached diffusion-controlled rates. Steroidal amines generally had good activity. Anionic and nonionic surfactants had little or negative activity.
mesh_terms: D000588:Amines / Q000494:pharmacology; D002769:Cholelithiasis / Q000378:metabolism*; D002784:Cholesterol / Q000378:metabolism*; D012995:Solubility; D013268:Stimulation, Chemical; D013329:Structure-Activity Relationship; D013501:Surface-Active Agents / Q000494:pharmacology
chemical_list: D000588:Amines; D013501:Surface-Active Agents; D002784:Cholesterol