title: [Toxicological properties of benzanthrone and its derivatives in relation to their chemical structure].
abstract: The paper presents a comparative study covering toxicological characteristics of benznthrone, brombenzanthrone, dibrombenzanthrone, methoxybenzanthrone, dibenzanronyl, dibenanthrone (violanthrone). The mentioned compounds were found to have a low acute and marked subchronic toxicity manifesting itself in the damaging action on the blood and liver. Here the reaction of the lympho-histiocytic elements along with the appearance of plasmatic and mast cells is typical. In the series of the study compounds most toxic are benzanthrone and its bromine-derivatives. Incorporation of a methoxy-group in the benzanthrone molecule and conjugation of two benzanthrone molecules help lessen the toxic action.
mesh_terms: D000818:Animals; D001551:Benz(a)Anthracenes / Q000633:toxicity*; D007928:Lethal Dose 50; D051379:Mice; D011817:Rabbits; D051381:Rats; D013329:Structure-Activity Relationship
chemical_list: D001551:Benz(a)Anthracenes; C012768:benzanthrone
vernacular_title: Toksikologicheskie osobennosti benzantrona i nekotorykh ego proizvodnykh s uchetom ikh khimicheskoĭ struktury.