title: Postoperative hemorrhage associated with carbenicillin administration. Report of two cases and review of the literature.
abstract: Two patients receiving preoperative carbenicillin manifested platelet dysfunction and severe wound hemorrhage. Platelet transfusions appeared beneficial. Investigations indicate that hemostatic abnormalities, especially platelet aggregation defects, may be produced by carbenicillin. Extreme caution and awareness of possible hemorrhage are advised when carbenicillin is used preoperatively.
mesh_terms: D000293:Adolescent; D000328:Adult; D000671:Amputation, Surgical; D001424:Bacterial Infections / Q000601:surgery; D001779:Blood Coagulation Factors; D001791:Blood Platelet Disorders / Q000139:chemically induced; D002228:Carbenicillin / Q000009:adverse effects* / Q000494:pharmacology; D005260:Female; D006470:Hemorrhage / Q000139:chemically induced*; D006801:Humans; D008297:Male; D010019:Osteomyelitis / Q000601:surgery; D010974:Platelet Aggregation / Q000187:drug effects; D011183:Postoperative Complications; D014947:Wounds and Injuries / Q000601:surgery
chemical_list: D001779:Blood Coagulation Factors; D002228:Carbenicillin