title: [Clinical studies of S-6437 in pediatrics (author's transl)].
abstract: Peak blood level of cephalexin was obtained at 4 hours after the administration of S-6437 as opposed to 2 hours after regular cephalexin. Peak blood level with regular cephalexin was higher than that with S-6437. Blood levels with S-6437, however, stayed for longer period than those with regular cephalexin. Mean urinary recovery within 12 hours after the administration of S-6437 after meal and during meal were 57.1 and 69.3%, respectively. S-6437 was studied in 23 pediatric patients, 7 with acute tonsillitis, 15 with acute cystitis and 1 with cellulitis. They were orally given 400 to 1,200 mg/day of S-6437 in two divided doses at 30 minutes after meal for 4 approximately 12 days. Of the 23 patients, 18 responded to the drug but 5 did not respond. As for side effects, eruption and diarrhea were observed in 1 and 2 patients, respectively. No other side effects were found.
mesh_terms: D000208:Acute Disease; D000284:Administration, Oral; D000293:Adolescent; D000367:Age Factors; D002481:Cellulitis / Q000188:drug therapy; D002506:Cephalexin / Q000008:administration & dosage / Q000378:metabolism* / Q000627:therapeutic use; D002648:Child; D002675:Child, Preschool; D003556:Cystitis / Q000188:drug therapy; D003692:Delayed-Action Preparations; D004334:Drug Administration Schedule; D004341:Drug Evaluation; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D013997:Time Factors; D014069:Tonsillitis / Q000188:drug therapy
chemical_list: D003692:Delayed-Action Preparations; D002506:Cephalexin