IgA class reticulin antibodies in relatives of patients with coeliac disease.
IgA class reticulin antibodies were not found in patients with Crohn's disease, ulcerative colitis, and hiatus hernia despite a significant incidence of IgG class reticulin antibodies. None of 56 normal healthy subjects was positive. In contrast, 13 (76%) of the sera from 17 patients with coeliac disease on normal diet were positive for IgA class antibodies as were 19 (20%) of 93 first degree relatives. Seventy-three relatives underwent jejunal biopsy. Grade III (flat) histology was found in 13 and, of these patients, 10 (77%) showed IgA class reticulin antibody in their serum. It is suggested that determination of IgA class reticulin antibodies was a useful test to determine which relative must be biopsied.
D000293:Adolescent; D000328:Adult; D000818:Animals; D001706:Biopsy; D002446:Celiac Disease / Q000175:diagnosis / Q000235:genetics / Q000276:immunology; D005260:Female; D006801:Humans; D007070:Immunoglobulin A / Q000032:analysis*; D007583:Jejunum / Q000473:pathology; D008297:Male; D008875:Middle Aged; D051381:Rats; D012155:Reticulin / Q000276:immunology*
D007070:Immunoglobulin A; D012155:Reticulin