Comparison of the antiarrhythmic activity of quinidine and quinine.
A comparison was made between the effects of quinidine and quinine on experimental arrhythmias and on cardiac electrophysiologic parameters. Both drugs raised ventricular fibrillation thresholds, reversed aconitine-induced atrial fibrillation, decreased ouabain-induced abnormal ventricular beats, and increased atrial refractory periods and His-Purkinje conduction time. In contrast, only quinidine antagonized acetylcholine-induced atrial fibrillation. In addition, quinidine increased ventricular fibrillation thresholds and atrial refractory periods for a longer time period than quinine. These observations are discussed in terms of choosing an appropriate model for testing new compounds with suspected quinidine-like activity.
D000109:Acetylcholine / Q000494:pharmacology; D000157:Aconitine / Q000494:pharmacology; D000818:Animals; D000889:Anti-Arrhythmia Agents; D001145:Arrhythmias, Cardiac / Q000139:chemically induced / Q000503:physiopathology; D001281:Atrial Fibrillation / Q000139:chemically induced / Q000503:physiopathology; D002036:Bundle of His / Q000187:drug effects; D002415:Cats; D004285:Dogs; D004558:Electric Stimulation; D005260:Female; D006352:Heart Ventricles; D008297:Male; D009431:Neural Conduction / Q000187:drug effects; D010042:Ouabain / Q000494:pharmacology; D011690:Purkinje Fibers / Q000187:drug effects; D011802:Quinidine / Q000494:pharmacology*; D011803:Quinine / Q000494:pharmacology*; D012032:Refractory Period, Electrophysiological / Q000187:drug effects; D013997:Time Factors; D014693:Ventricular Fibrillation / Q000503:physiopathology
D000889:Anti-Arrhythmia Agents; D010042:Ouabain; D011803:Quinine; D011802:Quinidine; D000109:Acetylcholine; D000157:Aconitine