title: Preparation and skin-photosensitizing activity of substituted psoralens.
abstract: 8-Monosubstituted and 5,8-disubstituted psoralen derivatives were prepared, and their skin-photosensitizing activity was evaluated. The results were correlated in terms of  molecular configuration, and 8-allyloxypsoralen can be considered was a new agent of potent photodynamic activity.
mesh_terms: D000277:Adjuvants, Pharmaceutic / Q000138:chemical synthesis; D000818:Animals; D003374:Coumarins / Q000138:chemical synthesis*; D005363:Ficusin / Q000138:chemical synthesis* / Q000494:pharmacology; D011564:Furocoumarins; D006168:Guinea Pigs; D008027:Light; D012867:Skin / Q000187:drug effects / Q000528:radiation effects*; D013329:Structure-Activity Relationship
chemical_list: D000277:Adjuvants, Pharmaceutic; D003374:Coumarins; D011564:Furocoumarins; D005363:Ficusin