Arylsulfonate esters of fatty alcohols as hypocholesterolemic agents. I: Oleyl and linoleyl p-toluenesulfonates.
Cholesterol levels of both plasma and liver of cholesterol-fed rats are lowered by feeding linoleyl and oleyl esters of p-toluenesulfonic acid. A structural specificity exists, since the effect is not observed with similar amounts of sodium p-toluenesulfonate nor with linoleyl methanesulfonate. Effective levels of these arylsulfonates do not alter liver to body weight ratios and maturation, nor reduce plasma cholesterol in normocholesterolemic rats.
D000818:Animals; D000924:Anticholesteremic Agents; D002791:Cholesterol, Dietary; D004041:Dietary Fats; D004353:Drug Evaluation, Preclinical; D006937:Hypercholesterolemia / Q000188:drug therapy*; D008041:Linoleic Acids / Q000627:therapeutic use*; D008297:Male; D009821:Oils; D009829:Oleic Acids / Q000627:therapeutic use*; D051381:Rats; D014105:Tosyl Compounds / Q000627:therapeutic use*
D000924:Anticholesteremic Agents; D002791:Cholesterol, Dietary; D004041:Dietary Fats; D008041:Linoleic Acids; D009821:Oils; D009829:Oleic Acids; D014105:Tosyl Compounds