[Metabolism and toxicity of therapeutic chelating agents. 15th communication: Effect of ca-DPTS and zn-DTPA on blood coagulatin (author's transl)].
Single subcutaneous injection of Ca-DTPA by a toxic dosage results with rats in a short-term moderate reduction of the plasma concentration of factors belonging to the endogenous coagulation system and of the prothrombin complex. Neither the temporary fibrinolysis nor the thrombocytopenia occurring later deeply affect coagulation as a whole. By fractionation of the daily dose or by continuous infusion of Ca-DTPA damage to the plasmatic coagulation system is not further increased, although the intensity of thrombocytopenia is enhanced which is miminum after single administration of the chelate. The platelet functions, on the other hand, are not influenced by Ca-DTPA. The much better compatibility of Zn-DTPA as compared to Ca-DTPA was fully confirmed also with respect to the hematological and coagulation parameters.
D000818:Animals; D001777:Blood Coagulation / Q000187:drug effects*; D001779:Blood Coagulation Factors / Q000032:analysis; D001792:Blood Platelets / Q000187:drug effects; D002118:Calcium; D005260:Female; D005342:Fibrinolysis; D004369:Pentetic Acid / Q000494:pharmacology*; D011516:Prothrombin / Q000032:analysis; D051381:Rats; D013921:Thrombocytopenia / Q000139:chemically induced; D013997:Time Factors; D015032:Zinc
D001779:Blood Coagulation Factors; D004369:Pentetic Acid; D011516:Prothrombin; D015032:Zinc; D002118:Calcium
Metabolismus und Toxizität therapeutischer Chelatbildner. 15, Mitteilung: Wirkung von Ca-DTPA und Zn-DTPA auf dei Blutgerinnung.