title: Evaluation of drug formulations using LD50 testing in mice.
abstract: The LD50 values were utilized to assess the relative rate of absorption of two very poorly soluble drugs. Formulations of these drugs were studied by micronization; addition of surfactant, alkaline or buffering agents, and/or bile salts; coprecipitation; melt or fusion techniques; or granulation with hydrophilic agents. Differences in toxicities were demonstrated from formulations compared to pure drugs by the LD50 method. This study shows that the LD50 is a practical, rapid method of achieving comparative evaluations of drug formulations.
mesh_terms: D000818:Animals; D001682:Biological Availability; D002626:Chemistry, Pharmaceutical; D004304:Dosage Forms; D004339:Drug Compounding; D007928:Lethal Dose 50; D051379:Mice; D004364:Pharmaceutical Preparations / Q000008:administration & dosage* / Q000378:metabolism; D014116:Toxicology
chemical_list: D004304:Dosage Forms; D004364:Pharmaceutical Preparations