title: Cell kinetic studies of prostatic cancer: adjuvant therapy in animal models.
abstract: Cell kinetic studies have been applied to the rat prostatic cancer R-3327-AT. This transplantable anaplastic tumor has a rapid growth rate and doubles its volume every 2.17 days. Cell kinetic considerations have been used to design a therapeutic approach which is capable of curing animals carrying this tumor, or providing long periods of complete remission. This treatment approach involves chemotherapy followed by surgery and immuno-stimulation with pyran copolymer. Such adjuvant tumor therapy is most effective against a small tumor load. The application of cell kinetic considerations to the control of human prostatic cancer is discussed.
mesh_terms: D000230:Adenocarcinoma / Q000473:pathology / Q000628:therapy*; D000818:Animals; D000970:Antineoplastic Agents / Q000627:therapeutic use; D002455:Cell Division; D005260:Female; D007167:Immunotherapy; D007700:Kinetics; D008297:Male; D009368:Neoplasm Transplantation; D009374:Neoplasms, Experimental / Q000473:pathology / Q000628:therapy; D011471:Prostatic Neoplasms / Q000473:pathology / Q000628:therapy*; D051381:Rats; D014184:Transplantation, Homologous
chemical_list: D000970:Antineoplastic Agents