A circular dichroism study of DNA-basic peptides associations in the absence or in the presence of Ca++.
The interaction of DNA with basic peptides (Lys methyl ester*, Lys2, (Lys)2methyl ester) has been studied by circular dichroism. The changes of the DNA CD spectra in the presence of peptides are interpreted as a transconformation from the B form to the C form of DNA. The presence of Ca++ in the mixture induces a supplementary transconformation. These observations suggest Ca++-basic peptides-DNA complexes as a structural model for chromatin.
D000818:Animals; D002118:Calcium / Q000494:pharmacology*; D002417:Cattle; D002942:Circular Dichroism; D004247:DNA; D008239:Lysine / Q000031:analogs & derivatives* / Q000494:pharmacology; D009690:Nucleic Acid Conformation / Q000187:drug effects*; D009842:Oligopeptides / Q000494:pharmacology; D013950:Thymus Gland
D009842:Oligopeptides; D004247:DNA; D008239:Lysine; D002118:Calcium