Methapyrilene toxicity.
Seven cases of drug overdosage involving methapyrilene have been presented, five of which resulted in death. Methapyrilene blood levels ranged fron 1.2 to 3.0 mg% (Table 2). Five of the seven cases involved multiple drug dosage with ethanol, salicylamide, amobarbital, secobarbital, and/or scopolamine. Of the remaining cases, involving only methapyrilene, ome fatality occurred at a blood level of 2.7 mg%. The surviving case involved the reported ingestion of 100 tablets of Sleep-eze (2.5 gm methapyrilene), wherein serial lavage removed 1.1 gm of methapyrilene. Urinalysis revealed 2.52 mg% of methapyrilene in 1300 ml of urine. The methapyrilene blood level was too low to quantitate.
D000328:Adult; D000368:Aged; D000431:Ethanol / Q000097:blood; D005260:Female; D006801:Humans; D008297:Male; D008701:Methapyrilene / Q000097:blood / Q000506:poisoning* / Q000633:toxicity; D008875:Middle Aged; D011725:Pyridines / Q000506:poisoning*; D013405:Suicide; D014018:Tissue Distribution
D011725:Pyridines; D000431:Ethanol; D008701:Methapyrilene