[Effect of estradiol on content of monoamines and acetylcholine in rat hypothalamus].
Administration of estradiol-benzoate in a dose of 0.5 Mg for 4 days causes a twice increase in the content of acetylcholine in hypothalamus of impuberal female rats and statistically significant decrease in the content of GABA. The level of serotonin, dopamine, noradrenaline and histamine in the hypothalamus of the animals is not affected by 0.5 Mg of estradiol-benzoate. Administration of prolactin against a background of estradiol--benzoate normalizes the content of GABA and produces a statistically significantly drop in the level of acetylcholine in the hypothalamus. A conclusion is drawn that acetylcholine and GABA are involved into regulation of prolactin secretion in rats.
D000109:Acetylcholine / Q000378:metabolism*; D000588:Amines / Q000378:metabolism*; D000818:Animals; D004298:Dopamine / Q000378:metabolism; D004958:Estradiol / Q000494:pharmacology*; D005260:Female; D006632:Histamine / Q000378:metabolism; D007031:Hypothalamus / Q000187:drug effects / Q000378:metabolism*; D008274:Magnesium / Q000494:pharmacology; D009638:Norepinephrine / Q000378:metabolism; D011388:Prolactin / Q000494:pharmacology; D051381:Rats; D012701:Serotonin / Q000378:metabolism; D005680:gamma-Aminobutyric Acid / Q000378:metabolism
D000588:Amines; D012701:Serotonin; D004958:Estradiol; D005680:gamma-Aminobutyric Acid; D006632:Histamine; D011388:Prolactin; D008274:Magnesium; D000109:Acetylcholine; D004298:Dopamine; D009638:Norepinephrine
Vpliv estradiolu na vmist monoaminiv ta atsetilkholinu v gipotalamusi shchuriv.