Chloride-sensitive glucose transport in Hymenolepis diminuta.
The maximal rate of glucose influx in Hymenolepis diminuta decreased when CL- in the incubation medium was replaced with acetate, benzoate, bicarbonate, formate, hippurate, iodide, lactate, mandelate, or nitrate. The effect of Cl- deletion on glucose influx using any of these anions was reversed when worms were incubated in Krebs-Ringer saline for 15 min. Glucose in the incubation medium increased 36Cl- influx in worms, while in Na+-free media the presence of glucose had no effect on 36Cl- influx. Influx of 10 mM 36Cl- in H. diminuta was inhibited by unlabeled Cl- in the incubation medium. Hymenolepis diminuta accumulated glucose aginst an apparent concentration differnce when Cl- in the incubation media was replaced with acetate, bicarbonate, or nitrate. The influx of Cl- appears couples with the influxes of Na+ and glucose, but the data do not show whether the influxex of these molecules are mediated through a common "carrier."
D000818:Animals; D001693:Biological Transport, Active / Q000187:drug effects; D002589:Cestoda / Q000378:metabolism*; D002712:Chlorides / Q000378:metabolism / Q000494:pharmacology*; D005947:Glucose / Q000378:metabolism*; D006926:Hymenolepis / Q000378:metabolism*; D008297:Male; D051381:Rats; D012964:Sodium / Q000378:metabolism
D002712:Chlorides; D012964:Sodium; D005947:Glucose