Increased sensitivity of chronic lymphocytic leukemia lymphocytes to alkylating agents due to a deficient DNA repair mechanism.
D004260:DNA Repair; D004273:DNA, Neoplasm / Q000096:biosynthesis*; D004305:Dose-Response Relationship, Drug; D006801:Humans; D006968:Hypersensitivity, Delayed; D007945:Leukemia, Lymphoid / Q000276:immunology / Q000378:metabolism*; D008466:Mechlorethamine / Q000494:pharmacology*
D004273:DNA, Neoplasm; D008466:Mechlorethamine