title: Adverse reactions to procainamide.
abstract: 1 Data from a comprehensive drug surveillance programme are analysed to provide details of procainamide use and toxicity in medical wards of teaching hospitals in five countries. 2 Out of a total of 488 recipients 9.2% had one or more adverse effect attributed to the drug; common effects being arrhythmias, gastro-intestinal upsets and drug fever. Although occasionally of major severity, no patient died as a consequence of procainamide toxicity. 3 Toxicity was directly related to total daily dose and duration of hospitalization but was not related to age, weight of the patient or presenting urea or albumin concentrations.
mesh_terms: D000368:Aged; D001145:Arrhythmias, Cardiac / Q000517:prevention & control; D005260:Female; D006352:Heart Ventricles; D006801:Humans; D008297:Male; D011342:Procainamide / Q000009:adverse effects* / Q000627:therapeutic use; D013997:Time Factors
chemical_list: D011342:Procainamide