Elevation of serum xanthine oxidase activity following halothane anesthesia in man.
Halothane, but not methoxyflurane, was found to cause specific hepatocellular damage, the hepatotoxicity being prompt but transient. The hepatotoxicity was demonstrated by the elevation in the serum activity of xanthine oxidase, a highly sensitive marker for acute liver damage.
D000758:Anesthesia; D001219:Aspartate Aminotransferases / Q000097:blood; D006221:Halothane / Q000494:pharmacology*; D006801:Humans; D007770:L-Lactate Dehydrogenase / Q000097:blood; D008733:Methoxyflurane / Q000494:pharmacology; D013997:Time Factors; D014969:Xanthine Oxidase / Q000097:blood*
D008733:Methoxyflurane; D007770:L-Lactate Dehydrogenase; D014969:Xanthine Oxidase; D001219:Aspartate Aminotransferases; D006221:Halothane