[Morphology of immune destruction of the erythrocytes in fetuses and newborn infants].
In the second half of pregnancy destruction of erythrocytes as a result of immunological aggresion in the fetus may occur in different manners: hemolysis in the vessel bed, fragmentation of erythrocytes, phagocytosis of intact erythrocytes and their fragments. Intravascular hemolysis occurs in immature fetuses. At that, the products of erythrocyte decomposition (hemosiderin and lipofuscin) are accumulated in the epithelial cells of the liver and the kidneys, the pancreas, the thyroid and the thymus. Fragmentation of erythrocytes (anuclear forms alone) occurs in the red splenic pulp and less in the vessels of the other organs. This process has been observed in fetuses after 7 months of gestation. Phagocytosis of erythrocytes and their fragments is done mainly by macrophages of the red splenic pulp as well as macrophages of the bone marrow, lymph nodes, and the Kupffer cells of the liver. Massive and long-term effect of iso (rhesus) antibody results in inhibition of the phagocytary activity of macrophages. In such cases, destruction of erythrocytes occurs in the vessel bed by lysis.
D004899:Erythroblastosis, Fetal / Q000097:blood* / Q000276:immunology; D004912:Erythrocytes / Q000276:immunology* / Q000473:pathology; D005260:Female; D005312:Fetal Blood / Q000166:cytology / Q000276:immunology*; D005333:Fetus / Q000276:immunology*; D006461:Hemolysis; D006801:Humans; D007231:Infant, Newborn; D010587:Phagocytosis; D011247:Pregnancy
Morfologiia immunnogo razrusheniia eritritsitov u plodov i novorozhdennykh.