Effects of somatostatin and human gastrin I on the lower esophageal sphincter in man.
The influence of gastrin and somatostatin on the lower esophageal sphincter was investigated in a total of ten metabolically healthy volunteers and one patient with Zollinger-Ellison syndrome. It could be shown that only unphysiologically high concentrations of gastrin produce a rise in pressure in the lower esophageal sphincter, while somatostatin has neither an effect on the lower esophageal sphincter pressure, nor is it able to inhibit the pharmacological effect of exogenic gastrin administration. The results of this study demonstrate that normal levels of serum gastrin do not seem to have much effect of resting LES pressure, nor does somatostatin. (Gastrin, in fact, in pharmacologic dosage does have an effecton the tonicity of the lower esophageal sphincter.)
D000328:Adult; D004943:Esophagogastric Junction / Q000187:drug effects*; D005755:Gastrins / Q000494:pharmacology*; D006801:Humans; D008365:Manometry; D011312:Pressure; D013004:Somatostatin / Q000494:pharmacology*; D015043:Zollinger-Ellison Syndrome / Q000503:physiopathology
D005755:Gastrins; D013004:Somatostatin