Biotransformation of antitumor agents by a strain of Whetzelinia sclerotiorum.
Antitumor antibiotics of the olivomycin and chromomycin class were transformed when incubated with a culture of Whetzelinia sclerotiorum. The products, when purified by counter-current distribution and column chromatography, were shown, by their physical properties, to be the deacylated analogues.
D001419:Bacteria / Q000187:drug effects; D001711:Biotransformation; D002865:Chromomycins / Q000378:metabolism* / Q000494:pharmacology; D005658:Fungi / Q000378:metabolism*; D003904:Mitosporic Fungi / Q000254:growth & development; D009848:Olivomycins / Q000378:metabolism* / Q000494:pharmacology
D002865:Chromomycins; D009848:Olivomycins