title: DNA repair enzymes in ataxia telangiectasia and Bloom's syndrome fibroblasts.
abstract: Ataxia telangiectasia, Bloom's syndrome and normal fibroblasts were compared as to the capacity of their cellular extracts to enhance the priming activity of gamma-irradiated colicin E1 DNA for purified DNA polymerase. It was found that an ataxia strain had substantially lower, and a Bloom's syndrome strain had slightly lower capacity than a normal strain; while the activities of apurinic site specific endonuclease in these extracts were comparable.
mesh_terms: D001260:Ataxia Telangiectasia / Q000201:enzymology*; D003087:Colicins; D004247:DNA / Q000528:radiation effects; D004260:DNA Repair; D004259:DNA-Directed DNA Polymerase / Q000378:metabolism*; D005347:Fibroblasts / Q000201:enzymology; D006801:Humans; D007700:Kinetics; D013577:Syndrome; D013684:Telangiectasis / Q000201:enzymology*; D013698:Templates, Genetic
chemical_list: D003087:Colicins; D004247:DNA; D004259:DNA-Directed DNA Polymerase