Effect of high-fat diet on colon carcinogenesis in F344 rats treated with 1,2-dimethylhydrazine, methylazoxymethanol acetate, or methylnitrosourea.
Male inbred F344 weanling rats were fed semipurified diets containing 20 or 5% beef fats. At 7 weeks of age, all animals except controls were given 1,2-dimethylhydrazine [DMH (150 mg/kg body weight s.c.; one dose)], methylazoxymethanol acetate [MAM acetate (35 mg/kg body weight i.p.; one dose)], or methylnitrosourea (2.5 mg/rat/week intrarectally; two doses), and autopsied 35 weeks later. No major differences were observed in the frequency (number of rats with tumor) of DMH- or MAM acetate-induced duodenal, ear duct, and kidney tumors between the rats fed diets containing 20 or 5% fat. However, the animals fed the diet containing 20% fat had slight although not statistically significant influence on the incidence of adenomas and adenocarcinomas in the colon.
D000230:Adenocarcinoma / Q000209:etiology; D000236:Adenoma / Q000209:etiology; D000818:Animals; D001391:Azo Compounds; D002417:Cattle; D003110:Colonic Neoplasms / Q000209:etiology*; D004041:Dietary Fats / Q000009:adverse effects*; D004127:Dimethylhydrazines; D008297:Male; D008460:Meat; D008746:Methylazoxymethanol Acetate; D008763:Methylhydrazines; D008770:Methylnitrosourea; D009374:Neoplasms, Experimental / Q000209:etiology; D009607:Nitrosourea Compounds; D051381:Rats; D011916:Rats, Inbred F344
D001391:Azo Compounds; D004041:Dietary Fats; D004127:Dimethylhydrazines; D008763:Methylhydrazines; D009607:Nitrosourea Compounds; D008746:Methylazoxymethanol Acetate; D008770:Methylnitrosourea