title: [Cardiac and selective vascular effects of canrenoate-potassium (aldactone pro injectione) in cardiosurgical patients (author's transl)].
abstract: Hemodynamic and inotropic effects of 200 mg and 400 mg Aldactone pro injectione (Canrenoate-Potassium, Aldadiene) were measured in three different series (n=60) during and after cardiac surgery in neuroleptanalgesia; results were compared to a control group (n=35). The first investigation was performed after sternotomy and pericardiotomy. During a measuring period of ten minutes no significant changes in inotropic parameter dp/dt max were found in comparison to individual control values. The second investigation during "steady state" extracorporeal circulation revealed a small decrease in arterial perfusion perfusion pressure after both dosages, which can be interpreted as an arteriolar vasodilatation. There was, however, no significant difference in comparison to the control group. Additional measurements were done after cardiac surgery in a total of 20 patients (200 mg and 400 mg Aldactone pro injectione) during an investigation period of 60 min. In comparison to a control group (n=15) no significant differences in arterial pressure, heart rate, cardiac index, stroke index and pulmonary arterial pressure were found. There were no acute and direct positive inotropic effects of Canrenoate-Potassium after administration of 200 mg and 400 mg respectively in cardiosurgical patients.
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D001794:Blood Pressure / Q000187:drug effects; D002191:Canrenoic Acid / Q000494:pharmacology*; D002302:Cardiac Output / Q000187:drug effects; D005260:Female; D006331:Heart Diseases / Q000503:physiopathology / Q000601:surgery*; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D008297:Male; D008875:Middle Aged; D011245:Pregnadienes / Q000494:pharmacology*
chemical_list: D011245:Pregnadienes; D002191:Canrenoic Acid
vernacular_title: Uber die kardiale und selektive Gefässwirkung von Canrenoat-K (Aldactone pro injectione) bei herzchirurgischen Patienten.