Correlation of anxiety and related symptoms with cerebrospinal fluid 5-hydroxyindoleacetic acid in depressed women.
Cerebrospinal fluid 5-hydroxyindoleacetic acid levels were determined in 31 women with unipolar involutional depression using the probenecid technique. Values were found to be lower in depression as compared to controls, but they did not correlate with the severity of the clinical picture. Anxiety, insomnia and drug response however showed significant correlation with pretreatment 5-HIAA level. Some possible interpretations are discussed.
D000328:Adult; D000639:Amitriptyline / Q000627:therapeutic use; D001007:Anxiety / Q000134:cerebrospinal fluid*; D003863:Depression / Q000134:cerebrospinal fluid* / Q000188:drug therapy; D005260:Female; D006801:Humans; D006897:Hydroxyindoleacetic Acid / Q000134:cerebrospinal fluid*; D008875:Middle Aged; D011339:Probenecid; D007319:Sleep Initiation and Maintenance Disorders / Q000134:cerebrospinal fluid; D014149:Tranquilizing Agents / Q000627:therapeutic use
D014149:Tranquilizing Agents; D000639:Amitriptyline; D006897:Hydroxyindoleacetic Acid; D011339:Probenecid