title: Ecological investigations on arsenic dietary intake and endemic chronic poisoning in man: dose-response curve.
abstract: The city of Antofagasta (northern Chile), is an area of endemic chronic arsenic poisoning due to arsenic-polluted drinking water. In order to explore the possibility of a dose-response relationship, a dietary survey was carried out in 1972 in that city for measuring the daily fluid intake in the various age groups. The sample (N = 220) included 13 males and 13 females in each age group, except the 81-90 year-old group with 6 males and 6 females. A linear relationship was found between arsenic dose (mg/kg body weight/day) and age for males being P less than 0.001 (slope) and r = -0.6712; and for females P less than 0.001 (slope) and r = 0.6667. Age-specific prevalence rates per 100,000 population (both sexes combined) for chronic arsenic poisoning in Antofagasta Commune for the 1968-71 period, were plotted against mean arsenic doses (mg/kg body weight/day) by age group. A dose-response curve was computed, being F = 83.19, d.f. = 1,7 and P less than 0.01 (slope). The correlation coefficient was + 0.9604.
mesh_terms: D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000368:Aged; D001151:Arsenic / Q000032:analysis; D020261:Arsenic Poisoning; D001835:Body Weight; D002648:Child; D002675:Child, Preschool; D002677:Chile; D004032:Diet; D004305:Dose-Response Relationship, Drug; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D008875:Middle Aged; D012737:Sex Factors; D014877:Water Pollution, Chemical / Q000032:analysis
chemical_list: D001151:Arsenic