title: The effects of etomidate on arterial pressure, pulse rate and preganglionic sympathetic activity in cats.
abstract: We have studied the effects of etomidate on preganglionic cervical sympathetic activity, arterial pressure, and pulse rate. Normal and baroreceptor-denervated animals were studied. On the basis of findings it is concluded that etomidate exerts a minimal direct depressant action on the cardiovascular system. A profound depression of sympathetic tone was observed in spite of unaffected arterial pressure. Etomidate was also shown to possess a mild vagolytic action.
mesh_terms: D000818:Animals; D001794:Blood Pressure / Q000187:drug effects*; D002415:Cats; D003714:Denervation; D005045:Etomidate / Q000494:pharmacology*; D007093:Imidazoles / Q000494:pharmacology*; D011674:Pulse / Q000187:drug effects*; D013562:Sympathectomy; D013564:Sympathetic Nervous System / Q000187:drug effects*
chemical_list: D007093:Imidazoles; D005045:Etomidate