title: [Heat denaturation of hemocytocardiotoxin from the venom of the Central Asian cobra].
abstract: It has been stated that boiled for three hours haemocytocardiotoxin (HT) from cobra poison loses "direct" hemolytic activity and is unable to potentiate a haemolytic effect of phospholipase A. Surface activity of HT does not change. It is shown that in the course of heat denaturation the aggregation of toxin molecules to dimers and trimers takes place and electrophoretic mobility is decreased. The fluorescence of HT tyroxin residues supported the fact of its irreversible heat denaturation.
mesh_terms: D000818:Animals; D004179:Cobra Cardiotoxin Proteins; D004546:Elapid Venoms; D006358:Hot Temperature; D049449:Luminescence; D010740:Phospholipases; D011489:Protein Denaturation
chemical_list: D004179:Cobra Cardiotoxin Proteins; D004546:Elapid Venoms; D010740:Phospholipases
vernacular_title: Issledovanie teplovoĭ denaturatsii gemotsitokardiotoksina iz iada sredneaziatskoĭ kobry.