title: Complement-dependence of platelet serotonin release test in polytransfused  patients.
abstract: The research of platelet isoantibodies in patients with Cooley's anaemia was performed by simultaneous determination of the platelet-complement fixation  test, platelet factor 3 availability assay and 14C-serotonin release test. In 93% of the examined patients we obtained positive results with the 5HT-release test, which appeared to be a complement-dependent reaction in most  of the sera-containing isoantibodies, different from sera of patients affected by  autoimmune thrombocytopenia.
mesh_terms: D000293:Adolescent; D000328:Adult; D001792:Blood Platelets / Q000276:immunology* / Q000378:metabolism; D001803:Blood Transfusion; D002648:Child; D002675:Child, Preschool; D003165:Complement System Proteins; D006801:Humans; D007518:Isoantibodies / Q000032:analysis*; D010977:Platelet Factor 3; D012701:Serotonin / Q000097:blood*; D013789:Thalassemia / Q000276:immunology*; D013921:Thrombocytopenia / Q000276:immunology; D013997:Time Factors
chemical_list: D007518:Isoantibodies; D012701:Serotonin; D010977:Platelet Factor 3; D003165:Complement System Proteins