Somatomedin and growth hormone in the newborn.
Somatomedin (SM) levels were measured by porcine cartilage bioassay, and growth hormone (GH) levels by radioimmunoassay in 52 full-term umbilical cord plasma samples and 28 maternal plasma samples. The SM levels in cord plasmas was 0.50 +/- 0.19 units/ml (mean +/- SD) compared to an adult standard plasma pool of 1.0 units/ml. The cord GH levels were 41.7 +/- 36 mmicrogram/ml. The low relative value of SM in the cord plasma is consistent with that found during early childhood, and may reflect a lower level of requirement. The high neonatal GH levels are hypothesized to be a compensatory increase to overcome factors suppressing SM production in fetal life.
D000293:Adolescent; D000328:Adult; D004958:Estradiol / Q000097:blood; D005260:Female; D005312:Fetal Blood / Q000032:analysis*; D013006:Growth Hormone / Q000097:blood*; D006801:Humans; D007231:Infant, Newborn; D008297:Male; D011247:Pregnancy; D013002:Somatomedins / Q000097:blood*
D013002:Somatomedins; D004958:Estradiol; D013006:Growth Hormone