title: [The treatment of acute acoustic trauma (blast injury) with dextran 40 (author's transl)].
abstract: In a prospective study the results of treatment of 72 patients with deafness due to blast injury were assessed. All patients received infusions of Dextran 40. When treatment started within 3 days of the injury 74% showed complete recovery of hearing and the remaining 26% showed some improvement. When treatment started within 3 weeks of the injury 26.5% showed complete recovery, 61.8% had some improvement and 11.8% had no improvement. In 87.5% of those patients who attended after a longer interval no change in the audiograms occurred and only 12.5% had any significant improvement. The disappearance of tinnitus was effectively more common with early treatment. On account of these results the use of Dextran 40 is strongly advised.
mesh_terms: D001753:Blast Injuries / Q000150:complications; D003911:Dextrans / Q000627:therapeutic use*; D006317:Hearing Loss, Noise-Induced / Q000188:drug therapy*; D006801:Humans; D011446:Prospective Studies; D013997:Time Factors; D014012:Tinnitus / Q000188:drug therapy
chemical_list: D003911:Dextrans
vernacular_title: Die Behandlung knalltraumatischer Innenohrschäden mit Dextran 40.