title: [LP-X in the first month of life (author's transl)].
abstract: An abnormal lipoprotein can be detected in the sera of patients suffering from intra- and extrahepatic cholestasis. The specificity of LP-X detection for the diagnosis of cholestasis in adult persons was proved by extensive investigations. The aim of this study was to examine the specificity of LP-X with regard to cholestasis in the postnatal phase of premature and newborn infants. 1056 sera of 270 newborns were tested and in 75% of these cases LP-X was found to be positive. Three hypothetical explanations are given concerning the appearance of LP-X in the sera of premature and newborn infants. The semi-quantitative determination of LP-X also represents a possibility for differential diagnosis of obstructive jaundice in the neonatal period.
mesh_terms: D000328:Adult; D000367:Age Factors; D000469:Alkaline Phosphatase / Q000097:blood; D001663:Bilirubin / Q000097:blood; D001724:Birth Weight; D002779:Cholestasis / Q000097:blood* / Q000201:enzymology; D006801:Humans; D007231:Infant, Newborn; D007232:Infant, Newborn, Diseases / Q000097:blood*; D007234:Infant, Premature; D007235:Infant, Premature, Diseases / Q000097:blood*; D008074:Lipoproteins / Q000097:blood*; D013997:Time Factors
chemical_list: D008074:Lipoproteins; D000469:Alkaline Phosphatase; D001663:Bilirubin
vernacular_title: Die Bedeutung von LP-X in den ersten Lebensmonaten.