Enhancement of radiation effect on mouse intestinal crypt survival by timing of 5-fluorouracil administration.
There is a marked dependence of mouse crypt survival on the sequence of combined drug-radiation treatment and on the time lapse between irradiation and drug administration. When 5-fluorouracil is administered 6 hours after irradiation or later (up to 18 hours postirradiation), crypt survival drops significantly.
D000818:Animals; D004334:Drug Administration Schedule; D005472:Fluorouracil / Q000008:administration & dosage* / Q000494:pharmacology / Q000627:therapeutic use; D007413:Intestinal Mucosa / Q000528:radiation effects*; D008297:Male; D051379:Mice; D013997:Time Factors
D005472:Fluorouracil