title: Synthesis of two metabolites of (+)-propoxyphene.
abstract: Two minor metabolites of (+)-propoxyphene were prepared in both the (+/-) and (+) forms. The optically pure forms were synthesized by a degradative route from (+)-propoxyphene. The di-N-demethylated metabolite 10a,b had weak analgesic activity while the cyclized oxazine metabolite 7a was inactive.
mesh_terms: D000700:Analgesics / Q000138:chemical synthesis; D000818:Animals; D011431:Dextropropoxyphene / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000378:metabolism; D051379:Mice; D013237:Stereoisomerism
chemical_list: D000700:Analgesics; D011431:Dextropropoxyphene