title: Renal vein renin activity in primary hypertension: variability and influence of contrast material.
abstract: Despite recognized limitations, the renal vein renin ratio (RVRR) remains the most commonly used index of surgical curability in hypertensive patients with renal artery stenosis. It is generally held that a ratio exceeding 1.5 forecasts a favorable response to surgery. Measurement of this ratio in 40 patients with essential hypertension (no arteriographically demonstrated stenosis) showed 8 (20%) with RVRR over 1.5, confirming an overlap of this ratio between patients with essential and renovascular hypertension. Intra-arterial injection of contrast material influenced renal vein renin activity (RVRA) in some individuals, but we were unable to demonstrate significant alterations in the group as a whole. Since the influence of intra-arterial contrast material on RVRA is variable and unpredictable, it appears unwise to collect renal venous blood for renin measurements soon after angiography.
mesh_terms: D000328:Adult; D000792:Angiography; D003287:Contrast Media; D003974:Diatrizoate Meglumine; D006801:Humans; D006973:Hypertension / Q000097:blood* / Q000000981:diagnostic imaging; D006977:Hypertension, Renal / Q000097:blood / Q000000981:diagnostic imaging; D008297:Male; D008875:Middle Aged; D012077:Renal Artery / Q000000981:diagnostic imaging*; D012082:Renal Veins; D012083:Renin / Q000097:blood*
chemical_list: D003287:Contrast Media; D003974:Diatrizoate Meglumine; D012083:Renin