title: Effects of sympathetic nerve stimulation in the presence of a slow parasympathetic secretion in the parotid and submaxillary glands of the rabbit.
abstract: Sympathetic secretory responses from the parotid and the submaxillary glands of the rabbit were  studied; sympathetic excitation occurred either alone or during a slow parasympathetic background secretion, imitating the resting secretion normally present. The fairly rapid sympathetically evoked flow of saliva from the parotid gland was, in the background secretion, further increased and obtained at low frequencies, which at sympathetic stimulation alone were subthreshold. The effects, which could be repeated with sympathomimetic drugs in a pilocarpine induced secretion, were abolished by alpha and beta-adrenoceptor blockade in combination. The submaxillary gland gave a very scanty secretion on sympathetic excitation, the effects being mediated via beta-adrenoceptors. The responses were not increased in a background secretion but the main effect of sympathetic activation was to retard the salivary flow. The retardation was attributed to vasoconstriction accompanying sympathetic excitation. Eliminating the vasoconstrictor responses, while retaining the sympathetic secretory effects, did not reveal any increase of the sympathetic salivary responses in the submaxillary gland.
mesh_terms: D000818:Animals; D004558:Electric Stimulation; D005071:Evoked Potentials; D010275:Parasympathetic Nervous System / Q000502:physiology*; D010306:Parotid Gland / Q000294:innervation / Q000378:metabolism*; D011817:Rabbits; D011941:Receptors, Adrenergic / Q000187:drug effects; D012463:Saliva / Q000378:metabolism; D013363:Submandibular Gland / Q000294:innervation / Q000378:metabolism*; D013564:Sympathetic Nervous System / Q000502:physiology*; D013566:Sympathomimetics / Q000494:pharmacology; D014661:Vasoconstriction
chemical_list: D011941:Receptors, Adrenergic; D013566:Sympathomimetics