title: Ligated renal pedicles and duration of action of neostigmine and pyridostigmine.
abstract: 1. The duration of neostigmine or pyridostigmine antagonism of a (+)-tubocurarine (Tc) neuromuscular blockade was determined in the cat anterior tibialis-peroneal nerve preparation with and without ligated renal pedicles. 2. The infusion rate of Tc required to maintain a 90% depression of twitch tension was reduced from 8.8 +/- 1.4 (s.e.) to 3.4 +/- 0.6 mugkg-1 min-1 by renal pedicle ligation. 3. Renal pedicle ligation resulted in an increased duration of antagonism of Tc by both neostigmine and pyridostigmine.
mesh_terms: D000818:Animals; D002415:Cats; D066298:In Vitro Techniques; D007668:Kidney / Q000502:physiology*; D008026:Ligation; D009119:Muscle Contraction / Q000187:drug effects; D009388:Neostigmine / Q000494:pharmacology*; D011729:Pyridostigmine Bromide / Q000494:pharmacology*; D013997:Time Factors; D014403:Tubocurarine / Q000037:antagonists & inhibitors
chemical_list: D009388:Neostigmine; D011729:Pyridostigmine Bromide; D014403:Tubocurarine