[Protective effect of pyridoxilate on the hypoxic myocardium. Experimental studies].
The protective action of piridoxilate on hypoxic myocardium has been studied on rats in acute hypoxia (isolated heart, perfused with a non-oxygenated solution) and in prolonged hypoxia (3 days at high [3454 m] altitude). Piridoxilate maintained a higher ATP level with a much lower production of lactate. The mechanisms of action of piridoxilate are probably fairly similar to those of Na dichloracetate.
D000255:Adenosine Triphosphate / Q000378:metabolism; D000531:Altitude; D000818:Animals; D004338:Drug Combinations; D004734:Energy Metabolism / Q000187:drug effects; D006038:Glyoxylates / Q000627:therapeutic use*; D006321:Heart / Q000187:drug effects*; D000860:Hypoxia / Q000517:prevention & control*; D007773:Lactates / Q000378:metabolism; D010725:Phosphocreatine / Q000378:metabolism; D011736:Pyridoxine / Q000627:therapeutic use*; D051381:Rats
D004338:Drug Combinations; D006038:Glyoxylates; D007773:Lactates; D010725:Phosphocreatine; D000255:Adenosine Triphosphate; D011736:Pyridoxine
Effet protecteur du piridoxilate sur le myocarde hypoxique. Etudes expérimentales.