title: Increased fatigue of cochlear potentials after injection of KCl solution in the perilymph.
abstract: Cochlear microphonics (CM), action potentials (AP) and endochochlear potential (EP) were recorded on guinea pigs. The introduction of a small quantity of KCl solution (0.1 N) in the perilymph provoked a moderate decrease of CM and AP. During the period of depressed but stable amplitude, the presentation of intense sounds provoked an exaggerated susceptibility to fatigue and a delayed recovery. Similar changes were observed in the evolution of EP. However, the recovery was slower for EP than for CM. The results, as a whole, suggest that the fatigue which is manifested in the depression of cochlear potentials is related to a leakage of potassium ions from endolymph to fluids spaces within the organ of Corti.
mesh_terms: D000161:Acoustic Stimulation; D000200:Action Potentials / Q000187:drug effects; D000818:Animals; D003051:Cochlea / Q000187:drug effects*; D003864:Depression, Chemical; D004710:Endolymph / Q000032:analysis; D006168:Guinea Pigs; D009925:Organ of Corti / Q000187:drug effects / Q000378:metabolism; D010498:Perilymph / Q000032:analysis; D011189:Potassium Chloride / Q000378:metabolism / Q000494:pharmacology*
chemical_list: D011189:Potassium Chloride