title: Steroids: theoretical and experimental basis for utilization in prevention of contrast media reactions.
abstract: In vitro and in vivo studies were done to examine the effects of methylprednisolone on the adverse reactions induced by contrast media. At very high concentrations, the steroid potentiated the complement-activating effect produced in vitro by iodipamide, but inhibited the immune and nonimmune mechanisms of hemolysis. Rabbits pretreated for 3 days with intramuscular methylprednisolone (at high or low dosages) were significantly protected against an LD47 challenging dose of iodipamide. Those treated once with a low intravenous dose immediately prior to iodipamide challenge were protected to a lesser degree. Rabbits treated once with a very high intravenous dose of steroid evidenced no protection. A hyper-responsive dog was consistently protected against adverse reactions to injected sodium iothalamate by a 3-day steroid pretreatment.
mesh_terms: D000818:Animals; D003165:Complement System Proteins; D003287:Contrast Media / Q000009:adverse effects*; D004285:Dogs; D004342:Drug Hypersensitivity / Q000209:etiology / Q000517:prevention & control*; D006461:Hemolysis / Q000187:drug effects; D006801:Humans; D007458:Iodipamide / Q000008:administration & dosage / Q000009:adverse effects; D007482:Iothalamate Meglumine / Q000009:adverse effects; D007483:Iothalamic Acid / Q000009:adverse effects; D008775:Methylprednisolone / Q000627:therapeutic use; D011239:Prednisolone / Q000627:therapeutic use*; D011817:Rabbits
chemical_list: D003287:Contrast Media; D007483:Iothalamic Acid; D003165:Complement System Proteins; D011239:Prednisolone; D007458:Iodipamide; D008775:Methylprednisolone; D007482:Iothalamate Meglumine