[Effect of lysosome hydrolases on rat embryos].
The application of the lysosome enzymes (acid DNAase, RNAse phosphatase) on the 13th day of pregnancy resulted in the distinct embryolethal effect and the appearance of development abnormalities in the rat embryos. The labilisators of the lysosome membrane weaken the teratogenic activity of the chemical agents whereas the stabilisators strengthen it.
D000135:Acid Phosphatase / Q000502:physiology; D000818:Animals; D000962:Antimalarials / Q000009:adverse effects*; D000970:Antineoplastic Agents / Q000009:adverse effects*; D001562:Benzimidazoles / Q000009:adverse effects; D003851:Deoxyribonucleases / Q000502:physiology; D004720:Endonucleases / Q000502:physiology; D004837:Epinephrine / Q000494:pharmacology; D005260:Female; D006867:Hydrolases / Q000502:physiology*; D007328:Insulin / Q000494:pharmacology; D008247:Lysosomes / Q000187:drug effects / Q000201:enzymology*; D015122:Mercaptopurine / Q000009:adverse effects; D011247:Pregnancy; D011739:Pyrimethamine / Q000009:adverse effects; D051381:Rats; D012260:Ribonucleases / Q000502:physiology; D013723:Teratogens / Q000037:antagonists & inhibitors
D000962:Antimalarials; D000970:Antineoplastic Agents; D001562:Benzimidazoles; D007328:Insulin; D013723:Teratogens; D015122:Mercaptopurine; D006867:Hydrolases; D003851:Deoxyribonucleases; D004720:Endonucleases; D012260:Ribonucleases; D000135:Acid Phosphatase; D004837:Epinephrine; D011739:Pyrimethamine
Vliianie gidrolaznykh fermentov lizosom na zarodysheĭ krys.