[Modification during treatment of the rate of acetylation of isoniazide clinically or biologically detectable hepatic damage (author's transl)].
The rate of acetylation of isoniazid is usually constant in a given subject. The authors report here a case where despite an adjusted initial dose there was a decrease in the rate of acetylation during treatment with INH-rifampicin and ethambutol, without hepatic involvement but accompanied by retrobulbar optic neuritis. The role of ethambutol and/or an overdose of isoniazid are discussed. The technique for its estimation is also described.
D000107:Acetylation; D004359:Drug Therapy, Combination; D004977:Ethambutol / Q000378:metabolism / Q000627:therapeutic use; D006801:Humans; D007538:Isoniazid / Q000008:administration & dosage / Q000009:adverse effects / Q000378:metabolism* / Q000627:therapeutic use; D008099:Liver / Q000187:drug effects; D008297:Male; D009902:Optic Neuritis / Q000139:chemically induced*; D012293:Rifampin / Q000378:metabolism / Q000627:therapeutic use; D014376:Tuberculosis / Q000188:drug therapy
D004977:Ethambutol; D007538:Isoniazid; D012293:Rifampin
Modification, en cours oe traitement, de la vitesse d'acétylation de l'isoniazide sans atteinte hépatique décelable.