[Modern principles for studying the organotropic side effects caused by antibiotics].
For prophylaxis of the organotropic side reactions in antibiotic therapy it is important to determine correlation between the drug blood level and the effect level. The study of this correlation under experimental conditions provides determination of the maximum permissible concentration of the antibiotic in the blood. When the antibiotic side effects are diagnosed in clinics it is advisable to determine as exact as possible the peculiar properties of the drug pharmacokinetics in the respective patients.
D000818:Animals; D000900:Anti-Bacterial Agents / Q000009:adverse effects* / Q000097:blood / Q000633:toxicity; D001702:Biopharmaceutics; D004305:Dose-Response Relationship, Drug; D006801:Humans; D007668:Kidney / Q000187:drug effects; D007700:Kinetics; D009336:Necrosis
D000900:Anti-Bacterial Agents
Sovremennye printsipy izucheniia organotropnykh pobochnykh éffektov, vyzyvaemykh antibiotikami.