title: The mechanism of the inactivation of human fibroblast interferon by mechanical stress.
abstract: Interferon derived from human fibroblasts is readily inactivated during agitation and filtration. This inactivation has been shown to be largely a product of mechanical stress, and has been studied in detail by subjecting interferon to controlled shear stress using a rotational viscometer. The possible mechanism of this phenomenon is discussed.
mesh_terms: D002460:Cell Line; D003588:Cytopathogenic Effect, Viral / Q000187:drug effects; D004355:Drug Stability; D005347:Fibroblasts; D006801:Humans; D007372:Interferons / Q000096:biosynthesis / Q000494:pharmacology*; D007962:Leukocytes; D008168:Lung / Q000196:embryology; D012845:Sindbis Virus / Q000187:drug effects / Q000254:growth & development; D013314:Stress, Mechanical
chemical_list: D007372:Interferons