Antitumor plants. IV. Constituents of Simarouba versicolor.
beta-Sitosterol, epilupeo, amarolide-11-acetate, amarolide-2,11-diacetate, ailanthinone and glaucarubinone have been isolated from S. versicolor. The cytotoxic and antileukemic activities of extracts of this plant are due chiefly to glaucarubinone.
D000972:Antineoplastic Agents, Phytogenic / Q000302:isolation & purification; D005900:Glaucarubin / Q000031:analogs & derivatives / Q000302:isolation & purification*; D006571:Heterocyclic Compounds / Q000302:isolation & purification*; D010946:Plants, Medicinal / Q000032:analysis*; D011714:Pyrans / Q000302:isolation & purification*; D012855:Sitosterols / Q000302:isolation & purification*; D014118:Toxins, Biological / Q000302:isolation & purification; D014315:Triterpenes / Q000302:isolation & purification*
D000972:Antineoplastic Agents, Phytogenic; D006571:Heterocyclic Compounds; D011714:Pyrans; D012855:Sitosterols; D014118:Toxins, Biological; D014315:Triterpenes; C015235:glaucarubinone; D005900:Glaucarubin