[Amoxicillin and its excretion into bronchial secretion (author's transl)].
Various dates on amoxicillin (resorption, distribution, elimination, tissue passage, urinary excretion) are presented. The bacterial spectrum is more fully discussed. Amoxicillin is compared with ampicillin. Dosage and therapeutical results are presented. Within repeated bronchoscopic examinations necessary on account of bronchopulmonary affections determination of germs were done in 88 children. At the same time examination of ampicillin levels in bronchial secretions were performed after amoxicillin therapy with different high doses (3 x 125 mg to 3 x 750 mg) for 7 days. It could be shown that good antibiotic levels could be found in secretion specimens above all obtained 2 to 4 hours after the last amoxicillin administration. They could be found too, if there did not exist any purulent secretion or stronger inflammation. There are relations between the amount of dosage, the level in secretion as well as the influence on germs.
D000293:Adolescent; D000658:Amoxicillin / Q000008:administration & dosage / Q000378:metabolism* / Q000627:therapeutic use; D000667:Ampicillin / Q000031:analogs & derivatives*; D000818:Animals; D001980:Bronchi / Q000378:metabolism*; D002648:Child; D002675:Child, Preschool; D004305:Dose-Response Relationship, Drug; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D051379:Mice; D012141:Respiratory Tract Infections / Q000188:drug therapy / Q000378:metabolism; D013183:Sputum / Q000378:metabolism*
D000667:Ampicillin; D000658:Amoxicillin
Uber das Amoxicillin and seine Ausscheidung im Bronchialsekret.