title: Adenylate cyclase of human fat cell ghosts. Stimulation of enzyme activity by prostaglandins.
abstract: It has been shown that the human fat cell adenylate cyclase is activated by prostaglandins. Of the prostaglandins tested the E-type by causing about a 3-fold increase of enzyme activity, was more effective than the F-prostaglandins. Prostaglandin A2 had no stimulatory effect. Activation by prostaglandin E1 was not influenced by beta-adrenergic blockade in contrast to stimulation by epinephrine. Pretreatment of fat cells with trypsin resulted in an abolishment of PTH-sensitivity, but had no effect on prostaglandin responsiveness. These results suggest that the human fat cell adenylate cyclase is coupled to at least three distinct types of hormone receptors.
mesh_terms: D000262:Adenylyl Cyclases / Q000378:metabolism*; D000273:Adipose Tissue / Q000201:enzymology*; D002462:Cell Membrane / Q000201:enzymology*; D004837:Epinephrine / Q000494:pharmacology; D006165:Guanylyl Imidodiphosphate / Q000494:pharmacology; D006801:Humans; D010281:Parathyroid Hormone / Q000494:pharmacology; D011433:Propranolol / Q000494:pharmacology; D011453:Prostaglandins / Q000494:pharmacology*; D011458:Prostaglandins E / Q000494:pharmacology; D011460:Prostaglandins F / Q000494:pharmacology; D014357:Trypsin / Q000494:pharmacology
chemical_list: D010281:Parathyroid Hormone; D011453:Prostaglandins; D011458:Prostaglandins E; D011460:Prostaglandins F; D006165:Guanylyl Imidodiphosphate; D011433:Propranolol; D014357:Trypsin; D000262:Adenylyl Cyclases; D004837:Epinephrine