title: Three instructive cases of tiger snake (Notechis scutatus) envenomation--and how a radioimmunoassay proved the diagnosis.
abstract: Three unusual cases are described, in which, in separate incidents, young snake bite victims were found comatose. Tiger snake vemon was detected by radioimmunoassay in the urine and serum, and in one case on the clothing of these children. Gross myoglobinuria was present in all cases. The three cases demonstrate clearly the myolytic potential of tiger snake venom if specific treatment (administration of antivenom) is delayed. Extreme elevation of serum enzyme levels was found in the two victims who survived. Evidence was obtained that the major neurotoxin of tiger snake venom is absorbed at least partly via the lymphatics and that some is excreted in the urine.
mesh_terms: D058186:Acute Kidney Injury / Q000209:etiology; D001219:Aspartate Aminotransferases / Q000097:blood; D002648:Child; D005260:Female; D006801:Humans; D007770:L-Lactate Dehydrogenase / Q000097:blood; D008297:Male; D009212:Myoglobinuria / Q000209:etiology; D011863:Radioimmunoassay; D012909:Snake Bites / Q000150:complications / Q000175:diagnosis* / Q000201:enzymology; D012910:Snake Venoms / Q000032:analysis*
chemical_list: D012910:Snake Venoms; D007770:L-Lactate Dehydrogenase; D001219:Aspartate Aminotransferases