Effect of tibric acid on hepatic cholesterol synthesis in rats.
Male albino rats were administered various oral doses of tibric acid daily for 1 week. Serum cholesterol and triglyceride levels were reduced, but total liver content of cholesterol, phospholipids, and triglycerides was increased. Tibric acid treatment suppressed the incorporation of both [14C] acetate and [3H] mevalonate into cholesterol by liver homogenates.
D000085:Acetates / Q000378:metabolism; D000818:Animals; D002784:Cholesterol / Q000096:biosynthesis*; D000960:Hypolipidemic Agents / Q000494:pharmacology*; D008099:Liver / Q000187:drug effects / Q000378:metabolism*; D008297:Male; D008798:Mevalonic Acid / Q000378:metabolism; D010743:Phospholipids / Q000378:metabolism; D010880:Piperidines / Q000494:pharmacology*; D051381:Rats; D014280:Triglycerides / Q000378:metabolism
D000085:Acetates; D000960:Hypolipidemic Agents; D010743:Phospholipids; D010880:Piperidines; D014280:Triglycerides; D002784:Cholesterol; D008798:Mevalonic Acid