title: Concentration of clonazepam in serum and cerebrospinal fluid of the sheep.
abstract: Following intravenous administration of clonazepam to sheep there was rapid equilibration of cerebrospinal fluid and unbound serum concentrations of the drug. The pharmacokinetics of clonazepam in sheep describe a 2-compartment model and the large volume of distribution suggests tissue binding of clonazepam. There was wide variation in serum concentration and at least 2 mg of clonazepam was necessary to attain the recommended therapeutic concentration.
mesh_terms: D000818:Animals; D001570:Benzodiazepinones / Q000378:metabolism*; D002998:Clonazepam / Q000097:blood / Q000134:cerebrospinal fluid / Q000378:metabolism*; D012756:Sheep
chemical_list: D001570:Benzodiazepinones; D002998:Clonazepam