The effect of intrauterine fetal transfusion and a beta-sympathomimetic substance on the lecithin/sphingomyelin ratio in human amniotic fluid.
The apparently low incidence of respiratory distress syndrome in babies born prematurely after intrauterine transfusion and the simultaneous prophylactic administration of intravenous isoxsuprine (a beta-sympathomimetic agent) was investigated by serial study of amniotic fluid lecithin/sphingomyelin ratios. The ratio rose very significantly after intrauterine transfusions and significantly (but less markedly) after the administration of intravenous isoxsuprine alone.
D000653:Amniotic Fluid / Q000032:analysis / Q000187:drug effects*; D001805:Blood Transfusion, Intrauterine; D004899:Erythroblastosis, Fetal / Q000378:metabolism; D005260:Female; D005865:Gestational Age; D006801:Humans; D007556:Isoxsuprine / Q000494:pharmacology*; D010713:Phosphatidylcholines / Q000032:analysis*; D011247:Pregnancy; D013109:Sphingomyelins / Q000032:analysis*
D010713:Phosphatidylcholines; D013109:Sphingomyelins; D007556:Isoxsuprine