Combined mesterolon-clomiphene citrate therapy for treatment of oligospermia.
42 subfertile patients with normal levels of plasma testerone (26 subnormal, suffering from oligospermia) have been treated with a combination of clomiphene citrate (50 mg Clomid daily) and mesterolon (50 mg Proviron daily) over a period of at least 3-6 months. The treatment resulted in pregnancy in 6 cases and in a significant improvement of the sperm count in 16. In 7, however, whilst the sperm count improved the qualitative results were unsatisfactory as many sperms were immature. Restricted spermatogenesis and a sperm count below 5 million/ml must be considered unfavourable but does not constitute a counter-indication to the combined therapy. No hazardous complications were observed.
D002452:Cell Count; D002996:Clomiphene / Q000008:administration & dosage* / Q000627:therapeutic use; D013196:Dihydrotestosterone / Q000031:analogs & derivatives*; D004359:Drug Therapy, Combination; D005260:Female; D005640:Follicle Stimulating Hormone / Q000097:blood; D006801:Humans; D007986:Luteinizing Hormone / Q000097:blood; D008297:Male; D008655:Mesterolone / Q000008:administration & dosage* / Q000627:therapeutic use; D009845:Oligospermia / Q000097:blood / Q000188:drug therapy*; D011247:Pregnancy; D013091:Spermatogenesis; D013094:Spermatozoa
D013196:Dihydrotestosterone; D008655:Mesterolone; D002996:Clomiphene; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone