Rosamicin in urethral and vaginal secretions and tissues in dogs and rats.
In animal studies we investigated the distribution of rosamicin in plasma and urethral and vaginal tissues in rats as well as in urethral and vaginal secretions in dogs. We found concentration ratios between urethral secretion and plasma of 1.9 and between vaginal secretion and plasma of 2.4. The rosamicin concentrations in urethral and vaginal tissue significantly exceeded the levels of all other tissues investigated. Because rosamicin could be valuable for the treatment of bacterial urethritis and the colonization of the vaginal introitus with fecal bacteria in women, it should be investigated clinically in this respect.
D000617:Aminoglycosides / Q000097:blood / Q000378:metabolism; D000818:Animals; D000900:Anti-Bacterial Agents / Q000097:blood / Q000378:metabolism*; D004285:Dogs; D005260:Female; D008297:Male; D011467:Prostate / Q000378:metabolism; D051381:Rats; D013997:Time Factors; D014521:Urethra / Q000378:metabolism*; D001743:Urinary Bladder / Q000378:metabolism; D014621:Vagina / Q000378:metabolism*
D000617:Aminoglycosides; D000900:Anti-Bacterial Agents