title: Biological reactors for renal support.
abstract: The goal of this research is to develop systems that may be more nearly psysiologic in the treatment of chronic renal failure. The concept of using specific strains of microorganism to achieve this objective is the subject of this study. Studies to date have concentrated on the selection of appropriate microorganisms based upon the efficiency of removal of nitrogenous metabolites in batch reactors. Appreciable quantities of these substances can be removed in time periods approximating those of the interdialytic period. Results of studies indicate that mixed strains are required and that a unique interdependence among the species may be required and desirable for eventual application. Because of these encouraging results, further studies will concentrate on experiments designed to make applicable the concept or to utilize this concept in combination with other technologies for in vivo use. It is believed that further research could conceivably produce an alternative treatment of chronic renal failure.
mesh_terms: D000641:Ammonia / Q000378:metabolism; D001419:Bacteria / Q000378:metabolism*; D006801:Humans; D007676:Kidney Failure, Chronic / Q000378:metabolism / Q000628:therapy*; D008297:Male; D014508:Urea / Q000378:metabolism; D014527:Uric Acid / Q000378:metabolism; D014556:Urine / Q000382:microbiology
chemical_list: D014527:Uric Acid; D000641:Ammonia; D014508:Urea