title: Bovine protoporphyria: the first nonhuman model of this hereditary photosensitizing disease.
abstract: Protoporphyria, a photosensitizing disease documented only in humans, was transmitted as a recessive trait to seven female calves. Cutaneous lesions were extensive, and erythrocyte and fecal protoporphyrin concentrations exceeded by far those of human protoporphyria. Average ferrochelatase activity was decreased to one-half of normal in the liver of carriers, and to about one-tenth of normal in liver, kidney, heart, spleen, lung, and marrow of protoporphyrics.
mesh_terms: D000624:5-Aminolevulinate Synthetase / Q000378:metabolism; D000818:Animals; D002417:Cattle; D002418:Cattle Diseases / Q000097:blood / Q000235:genetics* / Q000503:physiopathology; D004195:Disease Models, Animal; D004912:Erythrocytes / Q000473:pathology; D005243:Feces / Q000378:metabolism; D005808:Genes, Recessive; D008190:Lyases / Q000172:deficiency*; D011164:Porphyrias / Q000235:genetics / Q000503:physiopathology / Q000662:veterinary*; D046351:Protoporphyria, Erythropoietic; D011524:Protoporphyrins / Q000097:blood; D014558:Urobilinogen / Q000378:metabolism
chemical_list: D011524:Protoporphyrins; D014558:Urobilinogen; D000624:5-Aminolevulinate Synthetase; D008190:Lyases