Low doses of 1,25-dihydroxycholecalciferol increase mature bone mass in adult normal rats.
Low doses of 1,25-DHCC cause a significant increase in trabecular and cortical bone mass of the mature rat skeleton by stimulated endosteal bone formation. The increased serum contents of calcium and inorganic phosphate give rise to a moderate nephrocalcinosis. An increased bone resorption occurs upon toxic dose levels causing profound nephrocalcinosis. Similar doses of 25-HCC do not affect the mature bone.
D000818:Animals; D001835:Body Weight; D001862:Bone Resorption / Q000187:drug effects; D001842:Bone and Bones / Q000187:drug effects*; D002118:Calcium / Q000097:blood; D004100:Dihydroxycholecalciferols / Q000008:administration & dosage / Q000494:pharmacology*; D006887:Hydroxycholecalciferols / Q000494:pharmacology*; D007668:Kidney / Q000032:analysis; D008297:Male; D008903:Minerals / Q000032:analysis; D051381:Rats
D004100:Dihydroxycholecalciferols; D006887:Hydroxycholecalciferols; D008903:Minerals; D002118:Calcium