[Mechanism of the lipid mobilizing effect of etimizol].
The influence of ethymizol on the mobilization of free fatty acids and the role of hormones of the pituitary-adrenal system in the lipolytic effect of this drug was studied in experiments on rats. The lipomobilizing effect of ethymizol was clearly expressed in the intact, hypophysectomized and adrenalectomized rats. The effect of the drug disappears in rats with a simultaneous extirpation of the pituitary and the adrenal glands, but it again manifests itself after hydrocortisone injection to these animals. A conclusion on the presence of direct ethymizol action on the mobilization of fatty acids and on the permissive role of corticosteroids in lipid mobilization effect of ethymizol was made.
D015062:11-Hydroxycorticosteroids / Q000652:urine; D000315:Adrenalectomy; D000818:Animals; D005042:Etimizol / Q000494:pharmacology*; D005230:Fatty Acids, Nonesterified / Q000097:blood; D006854:Hydrocortisone / Q000494:pharmacology; D007016:Hypophysectomy; D007093:Imidazoles / Q000494:pharmacology*; D008053:Lipid Mobilization / Q000187:drug effects*; D008297:Male; D010913:Pituitary-Adrenal System / Q000187:drug effects*; D051381:Rats
D015062:11-Hydroxycorticosteroids; D005230:Fatty Acids, Nonesterified; D007093:Imidazoles; D005042:Etimizol; D006854:Hydrocortisone
k mekhanizmu lipomobilizuiushchego deĭstviia étimizola.