[Use of Allium fistulosum L. seeds as a preliminary test for studying mutagenic factors in the environment (drugs)].
The mutagenic activity was studied for the following 14 psychotropic drugs: aminazinum, fluphenazinum-decanoate, thioproperazinum, reserpinum, chlordiazepoxidum, diazepam, oxazepam, trioxazin, tavor, dipheninum, hexamidinum, benzonalum, carbamazepinum, ethosuximidium. It is shown that carbamazepinum, benzonalum, chlordiazepoxidum considerably increase the frequency of chromosome aberrations in the Allium fistulosum L. cells. These drugs were selected for studying their mutagenic activity on the laboratory animals.
D000927:Anticonvulsants / Q000633:toxicity; D002869:Chromosome Aberrations; D002875:Chromosomes / Q000187:drug effects*; D008722:Methods; D009153:Mutagens / Q000032:analysis; D011619:Psychotropic Drugs / Q000633:toxicity*; D012639:Seeds / Q000187:drug effects*; D014149:Tranquilizing Agents / Q000633:toxicity
D000927:Anticonvulsants; D009153:Mutagens; D011619:Psychotropic Drugs; D014149:Tranquilizing Agents
Ispol'zovnaie smeian Allium fistulosum L. v kachestve predvaritel'nogo testa pri izuchenii mutagennykh faktorov okruzhaiushcheĭ sredy (lekarstvennykh sredstv).