Radioiron and erythropoiesis: methods, interpretation and clinical application.
Ferrokinetic studies have fallen somewhat out of fashion and this is probably because T 1/2, PIT and percentage utilization give a poor reflection of the state of erythropoiesis. Recent advances have, however, enabled total, effective and ineffective erythropoiesis to be measured. The technique is simple but time-consuming, and analysis of the data requires access to computing facilities. Nevertheless, when bone marrow erythroid activity must be assessed these radioiron methods offer a rational approach.
D000741:Anemia, Aplastic / Q000097:blood; D000743:Anemia, Hemolytic / Q000097:blood; D000747:Anemia, Hypochromic / Q000097:blood; D000749:Anemia, Megaloblastic / Q000097:blood; D004912:Erythrocytes / Q000378:metabolism; D004920:Erythropoiesis; D006801:Humans; D007501:Iron / Q000097:blood / Q000378:metabolism; D007504:Iron Radioisotopes; D007700:Kinetics; D013997:Time Factors; D014168:Transferrin / Q000378:metabolism
D007504:Iron Radioisotopes; D014168:Transferrin; D007501:Iron