Acute and chronic effects of tetrahydrocannabinols on monoamide oxidase activity: possible vehicle/tetrahydrocannabinol interactions.
The acute and chronic effects of delta9 and delta8-tetrahydrocannabinol (THC) were studied on the monoamine oxidase (MAO) acitvity of various organs of the rat. The experimental design included two vehicles for the cannabinols (1% Tween 80 in saline and ethanol) and a further control group, given saline only. Neither delta9 nor delta8-THC (1 and 14 mg/kg, i.p.) altered MAO activity after one day and no changes from the saline control were found in the vehicle-treated groups. However, drug (delta8 and delta9-THC 1 mg/kg, i.p.) and vehicle-induced changes were observed after 14 days (Tween 80) and 28 days (ethanol) of continuous daily treatment. These data were interpreted upon the basis of a possible time-dependent, vehicle/drug interaction at the level of outer mitochondrial membranes. Contrary to previously published reports, no compelling evidence was obtained for any inherent pharmacological effect of the cannabinols upon MAO activity.
D000818:Animals; D013759:Dronabinol / Q000494:pharmacology*; D004347:Drug Interactions; D000431:Ethanol / Q000494:pharmacology; D008297:Male; D008995:Monoamine Oxidase / Q000378:metabolism*; D014677:Pharmaceutical Vehicles / Q000494:pharmacology; D011136:Polysorbates / Q000494:pharmacology; D051381:Rats; D012965:Sodium Chloride / Q000494:pharmacology; D013997:Time Factors
D014677:Pharmaceutical Vehicles; D011136:Polysorbates; D000431:Ethanol; D012965:Sodium Chloride; D013759:Dronabinol; D008995:Monoamine Oxidase