Anaesthesia for patients susceptible to malignant hyperpyrexia. A study of pancuronium and methylprednisolone.
In a study of human malignant hyperpyrexia-susceptible muscle a comparison between pancuronium and methylprednisolone showed that both drugs produced qualitatively similar depression of the halothane-induced muscle contracture. From this and other evidence, it is suggested that pancuronium is a suitable drug for use in malignant hyperpyrexia-susceptible patients.
D000758:Anesthesia; D003286:Contracture / Q000139:chemically induced; D004305:Dose-Response Relationship, Drug; D006221:Halothane / Q000037:antagonists & inhibitors; D006801:Humans; D066298:In Vitro Techniques; D008305:Malignant Hyperthermia; D008775:Methylprednisolone / Q000494:pharmacology*; D009119:Muscle Contraction / Q000187:drug effects*; D010197:Pancuronium / Q000494:pharmacology*
D010197:Pancuronium; D006221:Halothane; D008775:Methylprednisolone