The influence of unsaturated fatty acids on prostaglandin-release in isolated perfused guinea-pig hearts.
Isolated perfused hearts of guinea-pig continuously release a prostaglandin-like substance into the effluent. Polyunsaturaed fatty acids, linoleic acid and arachidonic acid greater than linolenic acid, induced an increase in PG-efflux. Oleic acid was without effect. The results suggest that PG-formation is involved in the increase of contractile force and coronary flow after administration of linoleic, linolenic and arachidonic acids.
D000818:Animals; D005231:Fatty Acids, Unsaturated / Q000494:pharmacology*; D006168:Guinea Pigs; D006321:Heart / Q000187:drug effects*; D008041:Linoleic Acids / Q000494:pharmacology; D008042:Linolenic Acids / Q000494:pharmacology; D009200:Myocardial Contraction / Q000187:drug effects; D009829:Oleic Acids / Q000494:pharmacology; D010477:Perfusion; D011453:Prostaglandins / Q000378:metabolism*
D005231:Fatty Acids, Unsaturated; D008041:Linoleic Acids; D008042:Linolenic Acids; D009829:Oleic Acids; D011453:Prostaglandins