The relative sensitivity of pulmonary parenchymal cells to 239plutonium dioxide.
Alpha particles inhaled by mice affect primarily type II epithelial cells, whereas interstitial mononuclears, alveolar macrophages and type I epitehlium are much more resistant and apparently react secondarily. The cellular responses, qualitative and quantitative, exhibit a time-dose relationship.
D000512:Alpha Particles; D000818:Animals; D004307:Dose-Response Relationship, Radiation; D004847:Epithelial Cells; D004848:Epithelium / Q000528:radiation effects; D008168:Lung / Q000166:cytology / Q000528:radiation effects*; D008264:Macrophages / Q000528:radiation effects; D051379:Mice; D011005:Plutonium; D011650:Pulmonary Alveoli / Q000528:radiation effects
D011005:Plutonium