title: [Clinical studies on the effect of long term progestagen administration on the elimination of noramidopyrine methanesulfonate (Analgin)].
abstract: Pharmacokinetic investigations with the drug noramidopyrinmethansulfonatnatrium (Analgin) were performed in 8 patients who, for a longer period, had taken the progestagene derivative norethisterone acetate. The half life of elimination as expression of biotransformation is clearly increased after intake of norethisterone acetate. As Analgin undergoes an oxydative mechanism of disintegration, possible explanations for this prolongation of the half life of elimination are discussed in the light of relevant literature.
mesh_terms: D000328:Adult; D000368:Aged; D000632:Aminopyrine / Q000031:analogs & derivatives*; D001711:Biotransformation; D004177:Dipyrone / Q000097:blood / Q000378:metabolism*; D005260:Female; D006207:Half-Life; D006801:Humans; D008099:Liver / Q000378:metabolism; D008875:Middle Aged; D009640:Norethindrone / Q000008:administration & dosage; D013997:Time Factors
chemical_list: D000632:Aminopyrine; D004177:Dipyrone; D009640:Norethindrone
vernacular_title: Klinische Untersuchungen über den Einfluss langdauernder Progestageneinnahme auf den Abbau von Noramidopyrinmethansulfonatnatrium (Analgin).