Phagocyte dysfunction in common variable immune deficiency.
The history of a 13-year old boy is reported who suffered from frequent bacterial, enteroviral, and protozoal infections since late infancy. A decrease in the serum levels of IgG2, IgG3, IgA, a neutrophil dysfunction, and a partial cellular immune deficiency could be demonstrated. A deficiency of folic acid produced a pancytopenia which enhanced the patient's susceptibility to infections. The combined substitution of gammaglobulins and folic acid only was able to break this vicious cycle.
D000293:Adolescent; D000741:Anemia, Aplastic / Q000150:complications; D004406:Dysgammaglobulinemia / Q000150:complications; D005494:Folic Acid Deficiency / Q000150:complications; D006801:Humans; D007111:Immunity, Cellular; D007070:Immunoglobulin A; D007074:Immunoglobulin G; D007153:Immunologic Deficiency Syndromes / Q000175:diagnosis* / Q000473:pathology; D008297:Male; D008854:Microscopy, Electron; D009504:Neutrophils; D010587:Phagocytosis
D007070:Immunoglobulin A; D007074:Immunoglobulin G