[Effect of glutaryl-lecithins on human erythrocytes (author's transl)].
Effect of glutaryl-lecithins on red blood cells is studied and compared to effect to egg lysolecithins. 1. Glutaryl-lecithins exhibit a hemolytic activity which appears in the first minutes. The rate of hemolysis increases proportionally with glutaryllecithin concentration up to concentrations of 1 X 10(-7) mole. 2. Glutaryl-lecithins methylation causes a decrease of lytic activity; this might indicate that the carboxylic group plays a role in the process of hemolysis. 3. Glutaryl-lecithins can produce echinocytes, in a similar fashion to lysolecithins. These findings suggest that glutaryl-lecithin hemolytic activity plays an important role in the process of post irradiation hemolysis.
D004912:Erythrocytes / Q000187:drug effects*; D004913:Erythrocytes, Abnormal / Q000166:cytology; D005977:Glutarates; D006461:Hemolysis; D006801:Humans; D008244:Lysophosphatidylcholines / Q000494:pharmacology; D010713:Phosphatidylcholines / Q000494:pharmacology*; D010743:Phospholipids / Q000494:pharmacology
D005977:Glutarates; D008244:Lysophosphatidylcholines; D010713:Phosphatidylcholines; D010743:Phospholipids
Action des glutaryl-lécithines sur les globules rouges humains.