[Evaluation of the protective effect of Prussian blue, sodium alginate and calcium phosphate according to tumor development after single and chronic exposure to strontium 90 and cesium 137 mixture].
The mixture of radionuclides was employed in the concentrations of 100.0, 400.0 and 0.8, 2.0 mc/rat for strontium-90 and cesium-137 in single and chronic administration correspondingly. Prussian blue, sodium alginate and calcium were employed in amounts of 50 mg, 800 mg and 258 mg per rat a day. The data obtained are correlated with the results of the same experiments without using the protection. In compared doses of the irradiation the protective action of the substances under study was noted only in chronic experiments. In this case, the appearance of malignant neoplasms was nearly twice less, and the survival was 120 days longer. The absorbed doses were decreased by 17 times for cesium-137 in the whole body and nearly by 4 times for strontium-90 in the skeleton.
D000464:Alginates / Q000627:therapeutic use*; D000818:Animals; D002130:Calcium Phosphates / Q000008:administration & dosage / Q000627:therapeutic use*; D002588:Cesium Radioisotopes; D004396:Coloring Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D004341:Drug Evaluation; D004781:Environmental Exposure; D005260:Female; D005290:Ferric Compounds / Q000008:administration & dosage; D005295:Ferrocyanides / Q000008:administration & dosage / Q000627:therapeutic use*; D009381:Neoplasms, Radiation-Induced / Q000473:pathology*; D011837:Radiation-Protective Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D051381:Rats; D012964:Sodium / Q000008:administration & dosage; D013326:Strontium Radioisotopes
D000464:Alginates; D002130:Calcium Phosphates; D002588:Cesium Radioisotopes; D004396:Coloring Agents; D005290:Ferric Compounds; D005295:Ferrocyanides; D011837:Radiation-Protective Agents; D013326:Strontium Radioisotopes; D012964:Sodium; C000170:ferric ferrocyanide
Otsenka zashchitnogo deĭstviia berlinskoĭ fazuri, al'ginata natriia i kal'tsiia fosfornokislogo po vykhodu opukholeĭ pri odnokratnom : khronicheskom deistviĭ smesi strontsiia-90 i.