title: Synthesis of substituted benzoquinones and naphthoquinones with potential antituberculous activity.
abstract: Compounds were prepared through the reaction of benzoquinone, naphthoquinone and 2-methyl-1.4-naphthoquinone with several sulphonamides in common use. It is hoped that incorporation of these bacteriostatic agents with the high lipid solubility of the quinone used may afford a better bacteriostatic activity. Determination of the partition coefficient of some representative samples proved these compounds to have high lipid solubility.
mesh_terms: D000995:Antitubercular Agents / Q000138:chemical synthesis*; D007202:Indicators and Reagents; D009285:Naphthoquinones / Q000138:chemical synthesis*; D011809:Quinones / Q000138:chemical synthesis*; D012995:Solubility
chemical_list: D000995:Antitubercular Agents; D007202:Indicators and Reagents; D009285:Naphthoquinones; D011809:Quinones