Effect of thymoanaleptic agents on the course of experimental arterial hypertension and catecholamine content in tissues and urine.
Experimental hypertension was induced in rats by two methods. In the course of hypertension development the rats of experimental groups were treated with following tricyclic antidepressive agents: Imipramine, Opipramol, Amitriptylline and Nortriptylline injected in doses of 5.0 or 0.5 mg per 1 kg of body weight. Higher doses of the above drugs inhibited the development of hypertension, whereas the lower doses had no effect on arterial blood pressure.
D000818:Animals; D000928:Antidepressive Agents / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D001011:Aorta / Q000378:metabolism; D001794:Blood Pressure / Q000187:drug effects*; D001923:Brain Chemistry; D002395:Catecholamines / Q000037:antagonists & inhibitors / Q000378:metabolism* / Q000652:urine; D004305:Dose-Response Relationship, Drug; D006339:Heart Rate / Q000187:drug effects; D006973:Hypertension / Q000188:drug therapy* / Q000503:physiopathology; D009206:Myocardium / Q000378:metabolism; D051381:Rats; D014655:Vascular Resistance / Q000187:drug effects
D000928:Antidepressive Agents; D002395:Catecholamines