Bilateral retinal vasculitis associated with clotting disorders.
We found distinct alterations of the clotting and fibrinolytic mechanisms in a 27-year-old man who suffered from typical bilateral vasculitis, clinically and fluoroangiographically manifest as obstruction of the central retinal veins. The partial thromboplastin time was slightly increased, a partial clot lysis occurred after one hour, the plasminogen level was markedly low, and alpha2-macroglobulin was decreased, as were factor XII and IgG. Kallikrein was absent. Similar changes, though not so pronounced, were also found in the patient's son and in his brother.
D000328:Adult; D001778:Blood Coagulation Disorders / Q000150:complications*; D001779:Blood Coagulation Factors / Q000032:analysis; D001780:Blood Coagulation Tests; D002675:Child, Preschool; D003018:Clot Retraction; D004487:Edema / Q000150:complications; D005174:Factor XII / Q000032:analysis; D005451:Fluorescein Angiography; D006801:Humans; D007074:Immunoglobulin G / Q000032:analysis; D008259:Macroglobulins / Q000032:analysis; D008297:Male; D010211:Papilledema / Q000150:complications; D010958:Plasminogen / Q000032:analysis; D012164:Retinal Diseases / Q000150:complications*; D012166:Retinal Hemorrhage / Q000150:complications; D013925:Thromboplastin / Q000032:analysis; D014657:Vasculitis / Q000150:complications*
D001779:Blood Coagulation Factors; D007074:Immunoglobulin G; D008259:Macroglobulins; D005174:Factor XII; D010958:Plasminogen; D013925:Thromboplastin