[Changes in the rate of hexobarbital detoxication in rats during postnatal ontogenesis].
Studies have been made on changes in detoxication rate of hexenal in male and female rats ageing from 1 day to 32 months as revealed by the duration of sleep after the injection of a standard dose (100 mg/g) of the drug. It was shown that in the newborn rats of both sexes, the detoxication rate is the highest, decreasing 3-fold to the age of 45 days. Sexual differences were observed beginning from the 55-60th day, resulting originally from the increase in the duration of sleep in females during their earlier sexual maturation, and being significantly enhanced to the 75th day due to a sharp decrease of the duration of sleep in males. From the 3-4th day up to the 20-32nd month, sexual differences in the duration of sleep increase due to its progressive increase in females. In 3-32-month males, significant changes in the duration of sleep were not noted. Sexual differences in detoxication rate of hexenal persist also in old animals.
D000367:Age Factors; D000818:Animals; D000831:Animals, Newborn; D001711:Biotransformation; D004958:Estradiol / Q000494:pharmacology; D005260:Female; D006591:Hexobarbital / Q000378:metabolism*; D008658:Inactivation, Metabolic; D008297:Male; D008862:Microsomes, Liver / Q000378:metabolism; D012737:Sex Factors; D012741:Sexual Maturation; D013739:Testosterone / Q000494:pharmacology; D013997:Time Factors
D013739:Testosterone; D004958:Estradiol; D006591:Hexobarbital
Izmeneniia skorosti detoksikatsii geksobarbitala u krys v postnatal'nom ontogeneze.