In vitro activity of five oral cephalosporins against anaerobic pathogenic bacteria.
The in vitro inhibitory activities of cefaclor and and cefatrizine, two new orally absorbed cephalosporin antibiotics, against 44 isolates of anaerobic pathogenic bacteria were measured using the agar dilution procedure of the World Health Organization-International Collaborative Study. Tests also were performed with cephalexin, cephaloglycin, and cephadrine, as well as with the parenteral cephamycin antibiotic cefoxitin. Cefoxitin was the most active antibiotic and inhibited the majority of isolates at a concentration of less than or equal to 4 microgram/ml. None of the oral cephalosporins was clearly superior against all of the anaerobic isolates; only cephadrine and cefatrizine appeared to have any potential clinical value.
D001439:Bacteroides / Q000187:drug effects; D001441:Bacteroides fragilis / Q000187:drug effects; D002436:Cefatrizine / Q000494:pharmacology; D002440:Cefoxitin / Q000494:pharmacology; D002506:Cephalexin / Q000494:pharmacology; D002507:Cephaloglycin / Q000494:pharmacology; D002511:Cephalosporins / Q000494:pharmacology*; D003013:Clostridium / Q000187:drug effects; D004353:Drug Evaluation, Preclinical; D006089:Gram-Negative Anaerobic Bacteria / Q000187:drug effects*; D010460:Peptococcus / Q000187:drug effects; D011424:Propionibacterium / Q000187:drug effects
D002511:Cephalosporins; D002440:Cefoxitin; D002436:Cefatrizine; D002507:Cephaloglycin; D002506:Cephalexin