[Oxidative phosphorylation in rat heart mitochondria under administration of hydrocortisone and insulin].
The rate of oxidative phosphorylation was studied in heart mitochondria of rats which were administered hydrocortisone and then corticoid in combination with insulin. It is established that 5 h after a single administration of hydrocortisone oxidative phosphorylation increases slightly and is statistically insignificant. Injections of corticosteroids to animals for 14 days inhibit considerably the rate of oxidation and phosphorylation, cause a decrease in the values of respiratory control and APD/O coefficient. Administration of insulin simultaneously with hydrocortisone to animals normalizes these disturbances to a considerable extent.
D000818:Animals; D006854:Hydrocortisone / Q000494:pharmacology*; D007328:Insulin / Q000494:pharmacology*; D008929:Mitochondria, Heart / Q000187:drug effects / Q000378:metabolism*; D010085:Oxidative Phosphorylation / Q000187:drug effects*; D010101:Oxygen Consumption / Q000187:drug effects; D051381:Rats
D007328:Insulin; D006854:Hydrocortisone
Okisniuval'ne fosforiliuvannia v mitokhondriiakh sertsia shchuriv za vvedennia gidrokortizonu ta insulinu.