Cumulative dose-response curves for comparison of oral bronchodilating drugs. A study of salbutamol and fenoterol.
Cumulative dose-response curves for orally administered fenoterol and salbutamol concerning effects of FEV1, heart rate, blood pressure and tremor were constructed. Three doses of fenoterol (2.5, 5 and 15 mg) and salbutamol (2, 6 and 18 mg) were given. Fenoterol was found to have a slightly higher potency than salbutamol. There was no difference in the beta2-selectivity of the two drugs. Tremor was the dose limiting side effect for both drugs. Cumulative dose-response curves for oral beta2-stimulants can be constructed fairly easily and valid conclusions can be drawn concerning selectivity, occurrence of side effects and dose limiting side effects.
D000420:Albuterol / Q000494:pharmacology*; D001794:Blood Pressure / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D004983:Ethanolamines / Q000494:pharmacology*; D005260:Female; D005280:Fenoterol / Q000494:pharmacology*; D005541:Forced Expiratory Volume; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D008297:Male; D014202:Tremor
D004983:Ethanolamines; D005280:Fenoterol; D000420:Albuterol