[Stomach adenocarcinoma induction in rats by the combined administration of N-methyl-N-nitroso-N'-nitroguanidine precursors].
N-methyl-N'-nitroguanidine and sodium nitrite were administered as drinking water to non-inbred male rats at the level of Img/ml for over two years. Gastric adenocarcinomas were produced in 43.7% of rats surviving for 15.5 months when the first tumor was noticed. Gastric mucous membrane of other rats had morphological changes analogous to those induced by N-methyl-N-nitoroso-N'-nitroguanidine (MNNG). The results obtained indicate endogenous synthesis of MNNG from precursors in the stomach of rats.
D000230:Adenocarcinoma / Q000139:chemically induced*; D000284:Administration, Oral; D000818:Animals; D008297:Male; D008769:Methylnitronitrosoguanidine; D009374:Neoplasms, Experimental / Q000139:chemically induced; D009573:Nitrites; D051381:Rats; D012964:Sodium; D013274:Stomach Neoplasms / Q000139:chemically induced*; D013997:Time Factors
D009573:Nitrites; D008769:Methylnitronitrosoguanidine; D012964:Sodium
Induktsiia adenokartsinom zheludka u krys pri sovmestnom vvedenii predshestvennikov N-metil-N-nitrozo-N'-nitroguanidina.