title: Effect of parathyroid hormone and volume expansion on jejunal calcium, sodium, and water transport in the rat.
abstract: The effects of PTH on jejunal calcium, sodium, and water transport were studied in the rat in situ. In TPTx rats, as well as in normal rats, bovine PTH induced a decrease in net calcium, sodium, and water absorption. Additionally, lumen-to-plasma calcium flux was found decreased in both groups. Stimulation of endogenous PTH secretion by calcium-poor hyperoncotic albumin resulted in a similar decrease in net calcium, sodium, and water absorption. It is suggested that PTH has a direct inhibitory effect on jejunal calcium, sodium, and water absorption.
mesh_terms: D000418:Albumins / Q000494:pharmacology; D000818:Animals; D001810:Blood Volume; D002118:Calcium / Q000097:blood / Q000378:metabolism*; D003864:Depression, Chemical; D007408:Intestinal Absorption / Q000187:drug effects; D007583:Jejunum / Q000378:metabolism*; D008297:Male; D010281:Parathyroid Hormone / Q000378:metabolism / Q000494:pharmacology*; D051381:Rats; D012964:Sodium / Q000378:metabolism*; D013965:Thyroidectomy; D014867:Water / Q000378:metabolism*; D014882:Water-Electrolyte Balance
chemical_list: D000418:Albumins; D010281:Parathyroid Hormone; D014867:Water; D012964:Sodium; D002118:Calcium