Influence of crystal form on tensile strength of compacts of pharmaceutical materials.
The tensile strengths of compacts of different crystal forms of aspirin, sulfathiazole, and barbital were determined with a modified tablet hardness tester. For each material, the tensile strength could be correlated with the amount of plastic flow and/or crushing undergone by each crystal form during compression.
D001241:Aspirin; D001462:Barbital; D002626:Chemistry, Pharmaceutical; D003460:Crystallization; D004339:Drug Compounding; D006245:Hardness Tests / Q000295:instrumentation; D007785:Lactose; D010316:Particle Size; D013432:Sulfathiazoles; D013607:Tablets; D013718:Tensile Strength
D013432:Sulfathiazoles; D013607:Tablets; D001462:Barbital; D007785:Lactose; D001241:Aspirin