Effect of levamisole on malignant experimental neurinoma grown subcutaneously in a young rat: brief communication.
Levamisole, a drug that stimulates the immunologic defenses of the host, was tested on the experimental malignant neurinoma grown subcutaneously in young female inbred CDF rats in a 3-month trial. The drug resulted in prevention of tumor growth in 80% of the treated animals, whereas tumors grew in 100% of the controls. After discontinuation of the drug, none of the animals in the treated group showed evidence of tumor growth upon clinical and pathologic examination 1 month after drug treatment was terminated. Treated animals failed to show any side effects related to levamisole upon clinical and pathologic examination.
D000818:Animals; D005260:Female; D007978:Levamisole / Q000627:therapeutic use*; D009374:Neoplasms, Experimental / Q000188:drug therapy; D009442:Neurilemmoma / Q000188:drug therapy*; D051381:Rats; D011919:Rats, Inbred Strains; D012075:Remission, Spontaneous; D012983:Soft Tissue Neoplasms / Q000188:drug therapy*
D007978:Levamisole