Further studies on the SRS-A antagonist FPL 55712.
FPL 55712, previously reported to be a selective antagonist of SRS-A on the guinea-pig ileum, has now been shown to be similarly selective, though less potent, in its antagonism of contractions induced by SRS-A on in vitro preparations of respiratory smooth muscle (human bronchial strips and guinea-pig tracheal tubes). In vivo, bronchoconstriction induced in guinea-pigs by the endogenous release of SRS-A was partially inhibited by relatively large intravenous doses of FPL 55712 and by inhalation of aerosol compound. FPL 55712 was very rapidly cleared following intravenous administration.
D000818:Animals; D001980:Bronchi / Q000276:immunology; D002867:Chromones / Q000494:pharmacology*; D003251:Constriction, Pathologic / Q000276:immunology; D006168:Guinea Pigs; D006207:Half-Life; D006801:Humans; D007082:Ileum / Q000276:immunology; D013189:SRS-A / Q000037:antagonists & inhibitors*; D014132:Trachea / Q000276:immunology
D002867:Chromones; D013189:SRS-A