Experiments on mechanisms of metastasation: dependence on reaction susceptibility in the host.
The present paper describes experiments on artificial hematogenous metastasation of chemically induced tumours in mice and rats. Total-body irradiation prior to tumour cell application greatly increased metastatic dissemination. The metastasation is significantly inhibited by pretreatment of the animals with a carcinogenic agent. Similarly, a significant inhibition of metastatic growth was observed in primary tumour animals after surgery.
D000818:Animals; D000912:Antibodies, Neoplasm; D002273:Carcinogens; D007111:Immunity, Cellular; D008175:Lung Neoplasms / Q000276:immunology; D051379:Mice; D009362:Neoplasm Metastasis / Q000276:immunology*; D009368:Neoplasm Transplantation; D009374:Neoplasms, Experimental / Q000601:surgery; D011183:Postoperative Complications; D051381:Rats; D012008:Recurrence; D013997:Time Factors; D014184:Transplantation, Homologous
D000912:Antibodies, Neoplasm; D002273:Carcinogens