Effect of renal ischaemia in rats with obstructive jaundice.
The ability of kidneys to withstand renal ischaemia has been tested in jaundiced and non-jaundiced rats. No significant difference could be demonstrated between the two groups of animals except that renal weight increased greatly in the presence of jaundice. Both jaundiced and non-jaundiced animals showed a median lethal dose of renal ischaemia of approximately 120 min when renal function was tested by delayed opposite nephrectomy. It was shown that a recent laparotomy renders the kidney more susceptible to renal ischaemia.
D058186:Acute Kidney Injury / Q000209:etiology; D000818:Animals; D002779:Cholestasis / Q000150:complications*; D004195:Disease Models, Animal; D007511:Ischemia / Q000150:complications*; D007668:Kidney / Q000098:blood supply*; D009929:Organ Size; D051381:Rats; D012107:Research Design