[Haptenic function and metabolism of the disaccharides of the glomerular basement membrane in heterologous nephrotoxic antibody-induced glomerulonephritis in rats].
The disaccharide unit Glc-gal-hyl represents 6% of dry weight of the rat glomerular basement membrane. It has been shown to be a haptenic determinant of this membrane. It appears to be one of the targets of the lesions induced by nephrotoxic antibodies in the rat: the urinary excretion of Glc-gal-hyl (as well as of Gal-hyl and Hyl which may derive from Glc-gal-hyl by degradation) during the autologous phase of the rat glomerulonephritis is significantly increased. Simultaneously the biosynthesis of Glc-gal-hyl, as measured by the glomerular glucosyltransferase activity, is elevated by 72%.
D000818:Animals; D000906:Antibodies; D001485:Basement Membrane / Q000276:immunology; D004187:Disaccharides / Q000096:biosynthesis / Q000378:metabolism*; D005921:Glomerulonephritis / Q000209:etiology / Q000276:immunology / Q000378:metabolism*; D006027:Glycosides / Q000652:urine; D006241:Haptens; D007678:Kidney Glomerulus / Q000276:immunology / Q000378:metabolism; D011817:Rabbits; D051381:Rats
D000906:Antibodies; D004187:Disaccharides; D006027:Glycosides; D006241:Haptens
Role hapténique et métabolisme des unités disaccharidiques de la membrane basale glomérulaire au cours de la glomérulo-néphrite par anticorps néphrotoxiques hétérologues chez le rat.