Effects of propranolol on the responses of the rat stomach strip to prostaglandin E2.
Propranolol is a local anaesthetic, membrane-stabilizing drug as well as a beta blocker. 2 mug/ml is added to many PG bioassay systems in order to inhibit beta adrenergic effects. This concentration inhibited responses of the rat stomach strip to PGE2 concentrations below 5 x 10(-7)M but potentiated responses to higher PGE2 concentrations. In calcium-free buffer only the potentiation was seen. Propranolol may not be a suitable drug for use in PG bioassay systems.
D000818:Animals; D002021:Buffers; D004305:Dose-Response Relationship, Drug; D004357:Drug Synergism; D008297:Male; D011433:Propranolol / Q000494:pharmacology*; D011458:Prostaglandins E / Q000008:administration & dosage / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D013270:Stomach / Q000187:drug effects*
D002021:Buffers; D011458:Prostaglandins E; D011433:Propranolol