Focal abnormalities in mitochondrial distribution in muscle. Two atypical cases of so-called "central core disease".
Describing two new cases of so-called Central Core Disease, the authors revealed certain atypical features: The cores were formed in central as well as in peripheral position; they were observed in some apparently type II fibers; typical "structured" and "unstructured" cores coexisted with "reversed" core. Starting from this pictures a cycle of core formation was imaginated supposing to be initiated as the consequence of abnormal functional interrelationship between muscular and neural components in early myogenesis.
D000328:Adult; D002675:Child, Preschool; D005260:Female; D006801:Humans; D008297:Male; D008854:Microscopy, Electron; D008931:Mitochondria, Muscle; D009132:Muscles / Q000473:pathology*; D009135:Muscular Diseases / Q000473:pathology*