Flurbiprofen in rheumatoid arthritis therapy.
Preliminary findings are reported from an open study of 300 mg flurbiprofen daily in 24 patients and from 6 out of 30 patients treated so far in a double-blind crossover comparison of 300 mg flurbiprofen daily and 150 mg indomethacin daily in the treatment of rheumatoid arthritis. The results indicate that flurbiprofen is effective in relieving symptoms and is better tolerated than indomethacin. Using an experimental model in rats to assess the anti-inflammatory activity of flurbiprofen, data suggest that flurbiprofen is unable to prevent an immunological type of inflammation but is capable of modifying the type and extent of cellular infiltration.
D000818:Animals; D001172:Arthritis, Rheumatoid / Q000188:drug therapy*; D005260:Female; D005480:Flurbiprofen / Q000627:therapeutic use*; D006801:Humans; D007213:Indomethacin / Q000627:therapeutic use*; D007249:Inflammation / Q000188:drug therapy; D008297:Male; D011422:Propionates / Q000627:therapeutic use*; D051381:Rats
D011422:Propionates; D005480:Flurbiprofen; D007213:Indomethacin