[Ankylosing spondylitis (Bechterew) and tissue antigen HLA-B 27. II. HLA-B 27 negativity in classical clinical ankylosing spondylitis: no independent nosological entity].
The question, whether HLA-B27-negative patients with classical ankylosing spondylitis (AS) belong to a separate nosological entity, was studied by a standardized analysis of 12 clinical, 8 radiological and 6 laboratory criteria in 95 cases, including 7 with HLA-B27-negativity, who reinforced international criteria for classical AS. The results showed neither definite clinical nor radiological, or laboratory differences between the HLA-B27 negative and positive group. We conclude, that existence or absence of the tissue antigen HLA-B27 has no influence on inflammatory activity of skeletal or soft tissue manifestations of the disease. The group of HLA-B27-negative patients who fulfill the criteria of classical AS does therefore not seem to form a separate nosological entity.
D006680:HLA Antigens; D006801:Humans; D010388:Pelvis / Q000000981:diagnostic imaging; D011859:Radiography; D013131:Spine / Q000000981:diagnostic imaging; D013167:Spondylitis, Ankylosing / Q000276:immunology* / Q000473:pathology
D006680:HLA Antigens
Spondylitis ankylosans (Bechterew) und Gewebsantigen HLA-B27. II. HLA-B27-Negativität bei klinisch klassischer Spondylitis ankylosans: Kein eigenständige nosologische Entität.