Investigation on the reaction of molybdenum with collagen in vivo.
Male Wistar rats were treated with Mo in a single dose or over a period of 84 days. The course of molybdenum excretion after a single dose was expressed mathematically. It was shown that various tissues produced different excretion curves and a high retention was observed only in skin. In long-term treatment it was possible to ascribe this retention to direct binding of molybdenum to collagen. In contrast to some other heavy metals molybdenum causes a decrease of collagen stability. The mechanism of this effect is discussed.
D000818:Animals; D001665:Binding Sites; D003094:Collagen / Q000378:metabolism*; D006909:Hydroxyproline / Q000032:analysis; D008297:Male; D008982:Molybdenum / Q000008:administration & dosage / Q000378:metabolism* / Q000494:pharmacology; D009119:Muscle Contraction / Q000187:drug effects; D009126:Muscle Relaxation / Q000187:drug effects; D051381:Rats; D011919:Rats, Inbred Strains; D013997:Time Factors; D014018:Tissue Distribution
D008982:Molybdenum; D003094:Collagen; D006909:Hydroxyproline