Bioassay program for carcinogenic hazards of cancer chemotherapeutic agents.
Various compounds and combinations thereof, of promise in the treatment of neoplastic diseases, were tested for possible carcinogenicity in Swiss mice and Sprague-Dawley rats. Some of the compounds were fairly active carcinogens, while others showed little or no evidence of carcinogenicity. The carcinogenicity of the drug combinations was generally less than that of the individual components.
D000818:Animals; D000970:Antineoplastic Agents / Q000008:administration & dosage / Q000009:adverse effects*; D002273:Carcinogens; D003606:Dacarbazine / Q000009:adverse effects; D004353:Drug Evaluation, Preclinical; D004347:Drug Interactions; D005260:Female; D008175:Lung Neoplasms / Q000139:chemically induced; D008223:Lymphoma / Q000139:chemically induced; D008297:Male; D008325:Mammary Neoplasms, Experimental / Q000139:chemically induced; D051379:Mice; D009374:Neoplasms, Experimental / Q000139:chemically induced*; D010534:Peritoneal Neoplasms / Q000139:chemically induced; D051381:Rats; D012513:Sarcoma, Experimental / Q000139:chemically induced
D000970:Antineoplastic Agents; D002273:Carcinogens; D003606:Dacarbazine