title: [Experimental anti-androgenic activity of 4-nitro-3-trifluoromethylisobutyranilide (niftholide) in rats and guinea pigs].
abstract: In experiments on rats and guinea pigs is shown the capability of the synthetized nesteroid antiandrogen--4-nitro-3-trifluormethylisobutyranilide (niftholide) to block the stimulating effect of exogenous and endogenous testosteon on the prostate, seminal vesicles and levator ani muscle. The results of histological and morphometric investigations bear proof to inhibition of the hypertrophic reaction of theprostatic epithelium in response to introduction of the androgen. It is inferred that antiandrogenic effect of niftholide with respect to testerone manifests itself on the level of the target-organs.
mesh_terms: D000813:Anilides / Q000494:pharmacology*; D000818:Animals; D002369:Castration; D005485:Flutamide / Q000494:pharmacology*; D006168:Guinea Pigs; D008297:Male; D009132:Muscles / Q000187:drug effects; D009929:Organ Size; D011467:Prostate / Q000187:drug effects; D051381:Rats; D012669:Seminal Vesicles / Q000187:drug effects; D013739:Testosterone / Q000037:antagonists & inhibitors*
chemical_list: D000813:Anilides; D013739:Testosterone; D005485:Flutamide
vernacular_title: Eksperimental'noe izuchenie antiandrogennoĭ aktivnosti 4-nitro-3-triftormetilizobutiranilida (niftolida) u krys i morskikh svinok.