Therapeutic comparison of thiol compounds in severe paracetamol poisoning.
Twelve patients with toxic blood concentrations of paracetamol were treated with either cysteamine or amino-acid solution. None of the patients developed severe liver damage, although transient mild biochemical abnormalities developed in three. None of the patients treated with amino-acid solution had side effects due to therapy, whereas all those treated with cysteamine did. It is recommended that amino-acid solutions be used as a temporary measure in patients suspected of massive paracetamol overdose while awaiting estimation of blood paracetamol concentration.
D000082:Acetaminophen / Q000097:blood / Q000506:poisoning*; D000293:Adolescent; D000328:Adult; D000596:Amino Acids / Q000627:therapeutic use*; D003543:Cysteamine / Q000009:adverse effects / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D008111:Liver Function Tests; D008297:Male; D019966:Substance-Related Disorders
D000596:Amino Acids; D000082:Acetaminophen; D003543:Cysteamine