[Effects of prostaglandin E2 and F2alpha on the phospholipid metabolism in cotton pellet granuloma (author's transl)].
Effects of prostaglandin (PG)s on phospholipid metabolism in cotton pellet granuloma were studied. Fifty ng of PGE2 or PGF2alpha was injected twice a day for 3 days into cotton pellet which was implanted into the interscapular region of rats. Phospholipid content in granuloma tissue treated with PGE2 was about 3 times that of control. The incorporation of 32P-orthophosphate into phosphatidylcholine in granuloma treated with PGE2 was about 6 times that of control. The incorporation of 32P-orthophosphate into phosphatidylethanolamine was increased by PGF2alpha but not by PGE2. These results suggest that PGE2 and PGF2alpha have a different site of action in the proliferative inflammatory process.
D000818:Animals; D003368:Gossypium; D006099:Granuloma / Q000378:metabolism*; D008297:Male; D010743:Phospholipids / Q000378:metabolism*; D010756:Phosphoric Acids / Q000378:metabolism; D011458:Prostaglandins E / Q000008:administration & dosage / Q000494:pharmacology*; D011460:Prostaglandins F / Q000008:administration & dosage / Q000494:pharmacology*; D051381:Rats
D010743:Phospholipids; D010756:Phosphoric Acids; D011458:Prostaglandins E; D011460:Prostaglandins F