title: Fusion of hamster macrophages induced by lectins.
abstract: The fusion of hamster peritoneal macrophages by lectins is described. The conditions under which this occurs are very similar to those previously reported using glutaraldehyde-fixed red cells and anti-hamster macrophage serum. Under conditions in which macrophages are brought into contact before interiorisation of surface-bound lectin, fusion results. It is suggested again that in granulomas, binding of endocytosable material to more than one macrophage results in giant cell formation by a mechanism of simultaneous interiorisation.
mesh_terms: D000818:Animals; D002459:Cell Fusion; D002478:Cells, Cultured; D003208:Concanavalin A / Q000494:pharmacology; D006224:Cricetinae; D037102:Lectins / Q000494:pharmacology*; D008264:Macrophages / Q000187:drug effects*; D010529:Peritoneal Cavity / Q000166:cytology
chemical_list: D037102:Lectins; D003208:Concanavalin A