[The effect of dopamine on the renal function in dogs with chronic ligation of the common bile duct (author's transl)].
The influence of dopamine on glomerular filtration rate (GFR), renal plasma flow (ERPF) and urinary sodium excretion was investigated in dogs before and after a chronic bile duct ligation for a period of 16 days. 1. Dopamine (4 microgram/kg/min.) leads to an increase of GFR, ERPF and urinary sodium excretion. 2. There was no change of GFR and ERPF after bile duct ligation. Urinary sodium excretion was decreased. The decrease was, however, not significant (0.05 less than p less than 0.1). 3. After bile duct ligation dopamine induced increase of GFR and ERPF was of the same order as observed in the preoperative period. Compared with the preoperative values for sodium excretion the dopamine effect was lower (p less than 0.05). The present investigation shows that dopamine is worth trying in cases of obstructive jaundice accompanied by acute renal failure.
D000818:Animals; D002779:Cholestasis / Q000188:drug therapy; D003135:Common Bile Duct / Q000502:physiology*; D004285:Dogs; D004298:Dopamine / Q000494:pharmacology* / Q000627:therapeutic use; D005919:Glomerular Filtration Rate / Q000187:drug effects; D007668:Kidney / Q000098:blood supply / Q000187:drug effects / Q000502:physiology*; D008026:Ligation; D008297:Male; D012964:Sodium / Q000652:urine
D012964:Sodium; D004298:Dopamine
Das Verhalten der Nierenfunktion unter Dopamin nach Choledochusligatur beim Hund