Systemic metabolic alterations associated with repeated injections of a modified polyriboinosinic-polyribocytidylic acid complex.
Polyriboinosinic acid-polyribocytidylic acid complexed with poly-1-lysine and injected intramuscularly into rats (0.3 or 3.0 mg/kg) produced fever, altered leukocyte count, slightly depressed plasma zinc, increased amino acid uptake into liver, and increased plasma acute-phase globulins two- to threefold. It is suggested that these systemic metabolic alterations are indicative of a mild inflammatory response to this drug. The metabolic alterations may have to be taken into consideration when polyriboinosinic acid-polyribocytidylic acid complexed with poly-1-lysine is used in therapy.
D000596:Amino Acids / Q000378:metabolism; D000818:Animals; D005334:Fever / Q000139:chemically induced; D007249:Inflammation / Q000139:chemically induced; D007273:Injections, Intramuscular; D007962:Leukocytes / Q000187:drug effects; D008099:Liver / Q000378:metabolism; D008297:Male; D008660:Metabolism / Q000187:drug effects*; D011070:Poly I-C / Q000008:administration & dosage / Q000494:pharmacology*; D051381:Rats; D012712:Serum Globulins / Q000378:metabolism; D015032:Zinc / Q000097:blood
D000596:Amino Acids; D012712:Serum Globulins; D015032:Zinc; D011070:Poly I-C