Selective inhibition of the monosynaptic spinal reflex by a series of hydroxylated alkylaminoindans.
5-Hydroxy-2-piperidino-4,5,6,7-tetrahydroindan (5) and a number of related tetrahydro and dihydro compounds were prepared by selective mono- and dihydroxylation of the dihydro products from the Birch reduction of various alkylaminoalkylindans, tetralins, benzenes, and isoindolines. Some of these compounds showed a remarkably selective inhibition of monosynatpic spinal reflex in the segmental cat preparation.
D000818:Animals; D002415:Cats; D003655:Decerebrate State; D003864:Depression, Chemical; D004558:Electric Stimulation; D006900:Hydroxylation; D007189:Indans / Q000138:chemical synthesis* / Q000494:pharmacology; D007192:Indenes / Q000138:chemical synthesis*; D012023:Reflex, Monosynaptic / Q000187:drug effects*; D013126:Spinal Nerve Roots / Q000187:drug effects / Q000502:physiology*
D007189:Indans; D007192:Indenes