Postural plasma aldosterone response in "upright hyperkalemia" associated with selective hypoaldosteronism.
Upright posture induced a consistent increase in serum K with a blunted plasma aldosterone response in four male renal patients with selective hypoaldosteronism. Dietary Na restriction induced a dramatic increase in the suppressed plasma aldosterone without returning the elevated serum K levels to normal and abolishing the postural serum K change. Therefore it is concluded that "upright hyperkalemia" may not be caused exclusively by suppression or/and inadequate postural response of aldosterone. Cellular disturbance in the regulation of K distribution might be an additional explantation for the aldosterone unresponsive postural K change.
D000328:Adult; D000368:Aged; D000450:Aldosterone / Q000097:blood*; D004039:Diet, Sodium-Restricted; D006801:Humans; D006947:Hyperkalemia / Q000209:etiology*; D008297:Male; D011187:Posture
D000450:Aldosterone