title: Two cases of monoclonal immunoglobulins with antistreptolysin activity: clinical and laboratory study.
abstract: In two patients with a persisting, high antistreptolysin titre the antistreptolysin activity in both cases resided exclusively in a monoclonal IgG component in the serum. This component had all the characteristics of a true antibody. A history in both patients of arthritis with or without angina suggested that the monoclonal antibodies were reactive in origin, although definite proof was lacking. In one case there was a suggestion of incipient myeloma. Whenever an extremely high antistreptolysin titre persists after antibiotic treatment the possibility of paraproteinaemia should be considered.
mesh_terms: D000989:Antistreptolysin / Q000032:analysis*; D002999:Clone Cells / Q000276:immunology; D004588:Electrophoresis, Cellulose Acetate; D005260:Female; D006801:Humans; D007122:Immunoelectrophoresis; D007140:Immunoglobulin Fab Fragments / Q000032:analysis; D007074:Immunoglobulin G / Q000032:analysis*; D008875:Middle Aged
chemical_list: D007140:Immunoglobulin Fab Fragments; D007074:Immunoglobulin G; D000989:Antistreptolysin