13-cis-Retinoic acid: inhibition of bladder carcinogenesis induced in rats by N-butyl-N-(4-hydroxybutyl)nitrosamine.
Transitional cell carcinoma was induced in the bladders of male Fischer rats by 12 oral doses of the carcinogen N-butyl-N-(4-hydroxybutyl)nitrosamine. Feeding of 13-cis-retinoic acid after completion of carcinogen treatment diminished the number and severity of cancers and other proliferative lesions of the bladder.
D000818:Animals; D002085:Butylhydroxybutylnitrosamine; D002295:Carcinoma, Transitional Cell / Q000139:chemically induced / Q000188:drug therapy / Q000517:prevention & control*; D008297:Male; D009374:Neoplasms, Experimental / Q000139:chemically induced / Q000188:drug therapy / Q000517:prevention & control; D009602:Nitrosamines; D051381:Rats; D011916:Rats, Inbred F344; D014212:Tretinoin / Q000627:therapeutic use*; D001749:Urinary Bladder Neoplasms / Q000139:chemically induced / Q000188:drug therapy / Q000517:prevention & control*; D014801:Vitamin A / Q000031:analogs & derivatives*
D009602:Nitrosamines; D014801:Vitamin A; D002085:Butylhydroxybutylnitrosamine; D014212:Tretinoin