[Effect of isadrine and anapriline on permeability of myocardial histo-hematic barriers in conditions of acute ischemia].
When reproducing ischemia of the myocardium in acute experiments on rabbits and in tests with the isolated rabbit's heart an elevated permeability of the myocardial histo-blood barriers (HBB) to sodium sulphacyl in the region of ischemia and its boundary zone was established. Upon introduction of isadrine (2 mg/kg and 2-10-6 M) and anapriline (1 and 2.5 mg/kg; 2-10-6 and 10-5M) the permeability of the HBB to sodium sulphacyl within the ischemia zone and in areas of the myocardium contiguous to it diminished. The permeability of the myocardial HBB  in the intact zone did not change under the effect of the drugs. In in vitro experiments with erythrocytes by using the fluorescent test and methods for determination of the osmotic resistance the drugs were found to display the membranotropic activity. From the in vitro tests it follows that anapriline and isadrine exercise no antiprotease action.
D000208:Acute Disease; D000818:Animals; D001692:Biological Transport / Q000187:drug effects; D003327:Coronary Disease / Q000503:physiopathology*; D004912:Erythrocytes / Q000187:drug effects; D005260:Female; D006321:Heart / Q000503:physiopathology*; D066298:In Vitro Techniques; D007545:Isoproterenol / Q000494:pharmacology*; D008297:Male; D011433:Propranolol / Q000494:pharmacology*; D011817:Rabbits
D011433:Propranolol; D007545:Isoproterenol
Vliianie izadrina i anaprilina na pronitsaemost' gisto-gematicheskikh bar'erov miokarda v usloviiakh ostroĭ ishemii.