title: [Intravesical and intraurethral pressure studies: significance for the prognosis and the treatment of children with myelomeningocele (author's transl)].
abstract: By statistical analysis of premicturition bladder pressure and urethral pressure in 37 children with myelomeningocele we were able to find four different types of neuropathic bladder dysfunction: 1. Group A (N = 19): No upper urinary tract dilatation and deterioration was seen with normal intravesical and low to normal intraurethral pressure. A conservative approach was warranted. 2. Group B (n = 6): Overflow incontinence due to low intravesical and high intraurethral pressure was found in this group. Upper urinary tract deterioration could be avoided and continence achieved by partial sphincterotomy. 3. Group C (n = 6): Progressive impairment in upper urinary tract dilatation was observed in four out of six children with high intravesical and low intraurethral pressures. In these children we prefer the urinary diversion. 4. Group D (n = 6): A dangerous impairment in upper urinary tract dilatation was found in four out of six children with high intravesical und high intraurethral pressures. When phenoxybenzamin therapy fails urinary diversion is the treatment of choice in this group.
mesh_terms: D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007223:Infant; D007674:Kidney Diseases / Q000209:etiology; D008297:Male; D008365:Manometry; D008591:Meningomyelocele / Q000150:complications / Q000503:physiopathology*; D010643:Phenoxybenzamine / Q000627:therapeutic use; D011312:Pressure; D011379:Prognosis; D014515:Ureteral Diseases / Q000209:etiology; D014521:Urethra / Q000503:physiopathology*; D001743:Urinary Bladder / Q000503:physiopathology*; D001745:Urinary Bladder Diseases / Q000209:etiology; D001750:Urinary Bladder, Neurogenic / Q000175:diagnosis / Q000503:physiopathology*; D014547:Urinary Diversion; D014555:Urination Disorders / Q000188:drug therapy / Q000503:physiopathology / Q000601:surgery; D014567:Urography
chemical_list: D010643:Phenoxybenzamine
vernacular_title: Manometrische Befunde in Blase und Harnröhre und ihre Bedeutung für Prognose und Behandlung bei Kindern mit Myelomeningozele.