Association between HLA-B7 and allergic reactions to insulin in insulin-dependent diabetes mellitus.
Forty-four cases of insulin-dependent diabetes mellitus with cutaneous allergic reactions to insulin were typed for HLA-A and -B antigens. HLA-B7, which commonly is negatively associated with insulin-dependent diabetes mellitus, showed a positive association with insulin allergy. A second antigen, HLA-Bw21 may also be positively associated with local insulin allergy. These data were discussed in relation to heterogeneity of insulin-dependent diabetes mellitus and to the existence of B7-associated immune response genes for allergic-immunoreactivity to insulin.
D000293:Adolescent; D000328:Adult; D000368:Aged; D002648:Child; D003920:Diabetes Mellitus / Q000188:drug therapy / Q000276:immunology*; D004342:Drug Hypersensitivity; D005260:Female; D006680:HLA Antigens / Q000032:analysis; D006801:Humans; D007328:Insulin / Q000276:immunology* / Q000627:therapeutic use; D007330:Insulin Antibodies; D008297:Male; D008875:Middle Aged
D006680:HLA Antigens; D007328:Insulin; D007330:Insulin Antibodies