[Pulse cytophotometric investigations concerning the biological behaviour of laryngeal carcinomas (author's transl)].
25 laryngeal carcinomas were investigated by pules cytophotometry, stained with ethidium bromide after pepsination. The karyograms were interpreted as DNA-distribution curves. In diploid populations the height  of the 4c-peak was taken as a measure of proliferation rate. Aneuploidy and polyploidy were estimated by camparison with human diploid material . In our material we found 13 polyploid tumors (under them 6 aneuploid populations from 7 at all). After dividing the cases into two groups (1: with slow, 2: with rapid progression) the moiety of polyploid and aneuploid tumors and the height of the 4c-peak was significantly higher in group 2. The pulse cytophotometry gives reliable additional informations showing the great variability of biological characteristics of laryngeal carcinomas. Possibly this is a basis of a more differentiated therapy.
D000782:Aneuploidy; D004273:DNA, Neoplasm / Q000032:analysis; D006801:Humans; D007620:Karyometry; D007822:Laryngeal Neoplasms / Q000473:pathology*; D010783:Photometry; D011123:Polyploidy
D004273:DNA, Neoplasm
Impulszytophotometrische Untersuchungen zum biologischen Verhalten von Larynxkarzinomen.