Robertsonian fusion leading to the formation of stable dicentric chromosome in an ascites cell line of the mouse.
The dicentric nature of a marker metacentric chromosome originated by robertsonian fusion has been established in the ascites cells of mouse sarcoma 180. C-banding analysis has revealed that the metacentric is actually a dicentric with 2 closely situated C-positive heterochromatic zones. The nature of the centromeres and the NF value of the cell indicate that this meta-dicentric marker has originated by breakage and fusion within each of the short arms of 2 acrocentric chromosomes.
D000818:Animals; D002459:Cell Fusion; D002460:Cell Line; D002503:Centromere / Q000648:ultrastructure; D002875:Chromosomes / Q000648:ultrastructure*; D051379:Mice; D012510:Sarcoma 180 / Q000235:genetics / Q000648:ultrastructure*