Metabolism of  three cyclic nitrosamines in Sprague-Dawley rats.
The metabolism of three cyclic nitrosamines has been studied in Sprague-Dawley rats. The compounds were nitrosopyrrolidine, nitrosohexamethyleneimine, and nitrosohepatamethyleneimine and were labeled at the alpha carbon with 14C. At low doses (2 to 4 mg/animal) the compounds were metabolized to 14CO2 to the extent of 77, 43, and 27%, respectively, after 24 hr. At doses closer to the 50% lethal dose of the compounds (70 to 160 mg/animal) the metabolism values were only 14, 4, and 8%, respectively, after 24 hr. The significance of these results is discussed.
D000388:Air / Q000032:analysis; D000818:Animals; D001381:Azepines / Q000378:metabolism; D001392:Azocines / Q000378:metabolism; D002245:Carbon Dioxide / Q000032:analysis / Q000652:urine; D004305:Dose-Response Relationship, Drug; D005260:Female; D007928:Lethal Dose 50; D009602:Nitrosamines / Q000008:administration & dosage / Q000378:metabolism*; D011759:Pyrrolidines / Q000378:metabolism; D051381:Rats
D001381:Azepines; D001392:Azocines; D009602:Nitrosamines; D011759:Pyrrolidines; D002245:Carbon Dioxide