[L-DOPA uptake and catecholamine synthesis in the brains of rats with altered adrenocortical hormone levels].
L-DOPA uptake by the brain and synthesis of dophamine and noradrenaline from it was studied in experiments on rats. L-DOPA (catecholamine precursor) was injected in a dose of 5 mg per 100 g of weight intraperitoneally simultaneously with hydrocortisone or 3 hours after its three-fold administration. Hydrocortisone at first intensified the uptake of L-DOPA by the brain, and, correspondingly, the dophamine synthesis. But three-fold administration of the hormone was followed by a fall of the L-DOPA and catecholamine content in the brain due to decreased L-DOPA diffusion from the blood. Oxidative catecholamine deamination was enhanced under the effect of hydrocortisone; it was prevented by prescription of nuredal, a MAO inhibitor.
D000818:Animals; D002395:Catecholamines / Q000096:biosynthesis*; D004298:Dopamine / Q000378:metabolism; D004347:Drug Interactions; D006854:Hydrocortisone / Q000494:pharmacology*; D007980:Levodopa / Q000378:metabolism*; D008996:Monoamine Oxidase Inhibitors / Q000494:pharmacology; D009638:Norepinephrine / Q000378:metabolism; D051381:Rats
D002395:Catecholamines; D008996:Monoamine Oxidase Inhibitors; D007980:Levodopa; D004298:Dopamine; D006854:Hydrocortisone; D009638:Norepinephrine
Pogloshchenie L-DOPA i sintez katekholaminov v mozge krys s izmenennym urovnem adrenokortikal'nykh gormonov.