Enterotoxin B production by Staphylococcus aureus under controlled fatty acid nutrition induced by cerulenin.
Cells of Staphylococcus aureus, strain S-6, can grow in the presence of 100 microgram of cerulenin/ml if the basal medium is supplemented with certain saturated or unsaturated fatty acids. The production of enterotoxin B (SEB) is markedly influenced by both the ratio of saturated to unsaturated fatty acid and by the melting point of the unsaturated fatty acid supplement. The results presented suggest that a certain degree of membrane fluidity promotes maximum SEB production and that greater or lesser degrees of membrane fluidity prohibit substantial SEB formation but fail to affect final growth density.
D000935:Antifungal Agents / Q000494:pharmacology*; D002462:Cell Membrane / Q000378:metabolism; D002569:Cerulenin / Q000494:pharmacology*; D004768:Enterotoxins / Q000096:biosynthesis*; D005227:Fatty Acids / Q000378:metabolism*; D005231:Fatty Acids, Unsaturated / Q000378:metabolism; D009829:Oleic Acids / Q000378:metabolism; D010169:Palmitic Acids / Q000378:metabolism; D013211:Staphylococcus aureus / Q000187:drug effects / Q000378:metabolism*
D000935:Antifungal Agents; D004768:Enterotoxins; D005227:Fatty Acids; D005231:Fatty Acids, Unsaturated; D009829:Oleic Acids; D010169:Palmitic Acids; D002569:Cerulenin