Reevaluation of the disulfiram-alcohol reaction in man.
The intensity of the disulfiram-alcohol reaction is found to depend on the blood acetaldehyde level, a disulfiram-induced predisposition reflected by alkalosis, and an individual predisposition reflected by dopamine-beta-hydroxylase activity.
D000437:Alcoholism / Q000188:drug therapy*; D001774:Blood Chemical Analysis; D001784:Blood Gas Analysis; D001794:Blood Pressure / Q000187:drug effects; D004221:Disulfiram / Q000378:metabolism / Q000494:pharmacology / Q000627:therapeutic use*; D004341:Drug Evaluation; D004347:Drug Interactions; D000431:Ethanol / Q000378:metabolism; D006801:Humans; D011674:Pulse / Q000187:drug effects; D013997:Time Factors
D000431:Ethanol; D004221:Disulfiram