Controlled demonstration of metrazol kindling.
Convulsive responses elicited in rats by intraperitoneal injections of metrazol were intensified following a seriew of metrazol injections administered once every three days. However, neither handling alone nor placebo injections increased the susceptibility of control rats to metrazol-induced convulsive symptoms. Thus, although increases in the susceptibility to metrazol seizures following periodic placebo injections have been reported by others, such increases do not appear to be a critical factor in metrazol kindling.
D000818:Animals; D008297:Male; D010433:Pentylenetetrazole / Q000008:administration & dosage / Q000494:pharmacology*; D051381:Rats; D012640:Seizures / Q000139:chemically induced* / Q000503:physiopathology; D013997:Time Factors
D010433:Pentylenetetrazole