[Testosterone and prostatic cancer (author's transl)].
Hormono-dependent epithelial cells of the prostate gland loose their histologic and cytologic differentiation when becoming neoplastic. Such loss of differentiation is related to a change in testosterone metabolism measured by the testosterone metabolites ratio (17 beta-hydroxy/17-oxometabolites). This ratio decreases with differentiation losses and increasing independence from androgenic steroids. Knowledge of that ratio is suggested, prior to the starting of antiandrogenic therapies.
D001706:Biopsy; D002295:Carcinoma, Transitional Cell / Q000378:metabolism; D006801:Humans; D008297:Male; D011467:Prostate / Q000378:metabolism*; D011471:Prostatic Neoplasms / Q000175:diagnosis / Q000188:drug therapy / Q000378:metabolism*; D013739:Testosterone / Q000378:metabolism*
D013739:Testosterone
Testostérone et cancer de la prostate.