Genetic control of two different types of antibody responses to oxazolone.
The genetic control of antibody responses induced by contact sensitization with oxazolone and immunization with an oxazolone-mouse serum albumin conjugate was studied in inbred, H-2 congenic and nude mice. Both types of antibody responses are T cell-dependent and regulated by immune response genes mapping at the I-B subregion of the H-2 complex. The relative magnitude of antibody responses induced by the two methods of immunization is governed by a gene or genes mapping at the I-B subregion of the H-2 complex. Presentation of antigen by these two methods gives H-2-dependent distributions of high and low responsiveness which are exactly opposite. Non-H-2 genes affect the overall level of antibody response but not the relative magnitude of the responses.
D000818:Animals; D000917:Antibody Formation; D001435:Bacteriophages; D002874:Chromosome Mapping; D005260:Female; D005796:Genes; D006386:Hemagglutination Tests; D006968:Hypersensitivity, Delayed / Q000276:immunology; D007074:Immunoglobulin G / Q000096:biosynthesis; D007075:Immunoglobulin M / Q000096:biosynthesis; D051379:Mice; D008815:Mice, Inbred Strains; D008819:Mice, Nude; D010080:Oxazoles / Q000276:immunology*; D010081:Oxazolone / Q000276:immunology*
D007074:Immunoglobulin G; D007075:Immunoglobulin M; D010080:Oxazoles; D010081:Oxazolone