Investigations of black bronchoalveolar human lavage fluid.
The removal by bronchoalveolar lavage (two occasions) of 10(11) black macrophages containing crystals of aluminum silicate, large amounts of amorphous carbon, and oxidized lipids was followed by considerable improvement in gas exchange in a patient. Sixty-eight percent of these pulmonary macrophages were viable and normal, as judged by chemotatctic and phagocytic activity. Except for cigarettes, no source for the previously mentioned ingested foreign substances was found. These observations suggest that removal by lavage of nonviable macrophages laden with foreign bodies from distal portions of the lungs of pulmonary patients may be therapeutically useful.
D002244:Carbon; D002633:Chemotaxis; D005547:Foreign Bodies / Q000150:complications; D006801:Humans; D008055:Lipids / Q000032:analysis; D008264:Macrophages / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D010587:Phagocytosis; D011650:Pulmonary Alveoli / Q000473:pathology*; D011658:Pulmonary Fibrosis / Q000209:etiology / Q000473:pathology* / Q000628:therapy; D012907:Smoking / Q000150:complications; D007507:Therapeutic Irrigation
D008055:Lipids; D002244:Carbon