HLA-A3 linked C3 deficiency in multiple sclerosis.
Many workers claim variations in quantity of functional activity of several components in the complement system in M.S. patients. Studies were performed in 58 M.S. patients, typing for HLA-SD specifities and C'3 complement component. We have been able to confirm a significant correlation between the hypocomplementaemic group (31.03%) with HLA-A3. In this connection we present some considerations on complement system and M.S.
D003176:Complement C3 / Q000172:deficiency*; D005260:Female; D006680:HLA Antigens; D006801:Humans; D008297:Male; D009103:Multiple Sclerosis / Q000276:immunology*
D003176:Complement C3; D006680:HLA Antigens