Cardiac mutant salamanders: evidence for heart induction.
Homozygosity for gene c in Ambystoma mexicanum results in no detectable heartbeat in situ. Alteration of the cardiac environment through organ culture results in rapid initiation of spontaneous heartbeat, indicating that absence of cardiac function in situ is not the result of failure of embryonic induction.
D000557:Ambystoma / Q000196:embryology* / Q000235:genetics; D000818:Animals; D004627:Embryonic Induction; D004707:Endoderm / Q000502:physiology; D005808:Genes, Recessive; D006321:Heart / Q000196:embryology*; D009154:Mutation; D009200:Myocardial Contraction; D009924:Organ Culture Techniques