Phenobarbital-induced brain growth retardation in artificially reared rat pups.
Phenobarbital was administered daily to rat pups during the period of their brain growth spurt. A new technique for artificially rearing rat pups, using chronic intragastric feeding cannulas, was used to prevent drug-induced undernutrition. Rats, receiving neonatal phenobarbital, experienced a marked interruption of early brain growth, although their body weights reflected normal growth.
D000818:Animals; D000831:Animals, Newborn; D001835:Body Weight / Q000187:drug effects; D001921:Brain / Q000187:drug effects / Q000254:growth & development*; D008297:Male; D009929:Organ Size / Q000187:drug effects; D010634:Phenobarbital / Q000008:administration & dosage / Q000494:pharmacology*; D051381:Rats
D010634:Phenobarbital