DNA repair enzymes in ataxia telangiectasia and Bloom's syndrome fibroblasts.
Ataxia telangiectasia, Bloom's syndrome and normal fibroblasts were compared as to the capacity of their cellular extracts to enhance the priming activity of gamma-irradiated colicin E1 DNA for purified DNA polymerase. It was found that an ataxia strain had substantially lower, and a Bloom's syndrome strain had slightly lower capacity than a normal strain; while the activities of apurinic site specific endonuclease in these extracts were comparable.
D001260:Ataxia Telangiectasia / Q000201:enzymology*; D003087:Colicins; D004247:DNA / Q000528:radiation effects; D004260:DNA Repair; D004259:DNA-Directed DNA Polymerase / Q000378:metabolism*; D005347:Fibroblasts / Q000201:enzymology; D006801:Humans; D007700:Kinetics; D013577:Syndrome; D013684:Telangiectasis / Q000201:enzymology*; D013698:Templates, Genetic
D003087:Colicins; D004247:DNA; D004259:DNA-Directed DNA Polymerase