The synthesis of total and specific glycosaminoglycans during development of experimental liver cirrhosis.
During hepatic fibrogenesis induced by long-term administration of thioacetamide, the synthesis of chondroitin 4,6-sulfate and hyaluronic acid was strongly enhanced; the formation of heparan sulfate comprising at least 70% of total liver GAG synthesis and of a keratan-sulfate-like fraction was stimulated 1.7 fold. Formation of dermatan-sulfate in liver could not be detected.
D000818:Animals; D002807:Chondroitin / Q000096:biosynthesis; D006025:Glycosaminoglycans / Q000096:biosynthesis*; D006497:Heparan Sulfate / Q000096:biosynthesis; D006820:Hyaluronic Acid / Q000096:biosynthesis; D007632:Keratan Sulfate / Q000096:biosynthesis; D008099:Liver / Q000378:metabolism*; D008106:Liver Cirrhosis, Experimental / Q000378:metabolism*; D008297:Male; D051381:Rats; D013997:Time Factors
D002807:Chondroitin; D006025:Glycosaminoglycans; D006497:Heparan Sulfate; D006820:Hyaluronic Acid; D007632:Keratan Sulfate