[Excretion of D-glucaric-acid in newborns with non-hemolytic hyperbilirubinemia after phenobarbital treatment (author's transl)].
The excretion of D-glucaric-acid during 24 hours in the urine, which is a measure for the activity of microsomal liver enzymes, was determined in 33 newborns. From 22 newborns with non-hemolytic unconjugated hyperbilirubinemia 11 were treated with 7.5 mg phenobarbital per kilogram bodyweight 5 days and afterwards the excretion of D-glucaric-acid was measured. In contrast to the untreated newborns there was a significant decrease of the bilirubin concentration in the serum and a concomitant increase of the D-glucaric acid excretion from 0,052 mumol/day/kg to 0,388 mumol/day/kg (mean values). A negative correlation (r = -0,51) could be calculated between the bilirubin concentration in the serum and the excretion of D-glucaric-acid after treatment with phenobarbital.
D001663:Bilirubin / Q000097:blood; D005260:Female; D005937:Glucaric Acid / Q000652:urine*; D006801:Humans; D006932:Hyperbilirubinemia / Q000097:blood / Q000188:drug therapy* / Q000652:urine; D007231:Infant, Newborn; D008297:Male; D010634:Phenobarbital / Q000627:therapeutic use*; D013400:Sugar Acids / Q000652:urine*; D013997:Time Factors
D013400:Sugar Acids; D005937:Glucaric Acid; D001663:Bilirubin; D010634:Phenobarbital
D-Glukarsäureausscheidung bei Neugeborenen mit transitorischer Hyperbilirubinämie nach Phenobarbitalbehandlung.