Biotransformation of sisomicin to gentamicin C2b.
Sisomicin was transformed to gentamicin C(2b) by Micromonospora rhodorangea NRRL 5326. The mechanisms involved in the biotransformation are the 6'-N-methylation and the (4'-5')-reduction. The progression of the methylation was followed by the isotope technique, but the reduction reaction was not monitored.
D005839:Gentamicins / Q000378:metabolism*; D008745:Methylation; D008847:Micromonospora / Q000378:metabolism*; D010084:Oxidation-Reduction; D012853:Sisomicin / Q000378:metabolism*
D005839:Gentamicins; D012853:Sisomicin