title: Mianserin in the prophylactic treatment of bipolar affective illness.
abstract: Mianserin in a dosage of 20 mg 3 times daily, was given to 13 patients with bipolar affective illness, who were previously maintained on lithium. 3 patients left the trial at their own request within a few days due to drowsiness in 2 cases and insomnia in the third. Of the remaining 10 patients, 6 became manic within the 3-month trial period. This result indicates that mianserin may be capable of precipitating mania in susceptible subjects with bipolar affective illness. This may be a general property of antidepressants, since it has been previously described with other groups of antidepressants.
mesh_terms: D000328:Adult; D000342:Affective Symptoms / Q000188:drug therapy* / Q000517:prevention & control; D001714:Bipolar Disorder / Q000188:drug therapy; D003984:Dibenzazepines / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D008297:Male; D008803:Mianserin / Q000009:adverse effects / Q000627:therapeutic use*; D008875:Middle Aged
chemical_list: D003984:Dibenzazepines; D008803:Mianserin