title: Metoclopramide metabolism and determination by high-pressure liquid chromatography.
abstract: A high-pressure liquid chromatographic method suitable for determining plasma metoclopramide levels at normal (10-20 mg) doses is  described. Eight metabolites as well as metclopramide were isolated and identified in rat, dog. and human urine. The only common metabolite in these species is 2-[(4-amino-5-chloro-2-methoxybenzoyl)-amino] acetic acid. N-Deethylation is a major pathway for metoclopramide metabolism in the lower animals but not in humans. Metoclopramide is excreted mainly unchanged or as its conjugates by humans.
mesh_terms: D000818:Animals; D001711:Biotransformation; D002851:Chromatography, High Pressure Liquid; D002855:Chromatography, Thin Layer; D004285:Dogs; D005260:Female; D006801:Humans; D008297:Male; D013058:Mass Spectrometry; D008787:Metoclopramide / Q000378:metabolism*; D051381:Rats
chemical_list: D008787:Metoclopramide