N-phenylglycolhydroxamate production by the action of transketolase on nitrosobenzene.
The incubation of nitrosobenzene with yeast transketolase and D-xylulose 5-phosphate resulted in the production of N-phenylglycolhydroxamic acid. The addition of D-ribose 5-phosphate decreased the amount of hydroxamic acid that was produced. This conversion of nitrosobenzene into the glycollic acid-derived hydroxamic acid was shown to be an enzymic process, and a chemical mechanism for the conversion was proposed.
D006877:Hydroxamic Acids / Q000096:biosynthesis*; D009603:Nitroso Compounds / Q000378:metabolism*; D010428:Pentosephosphates; D012267:Ribosemonophosphates / Q000494:pharmacology; D014174:Transketolase / Q000378:metabolism*
D006877:Hydroxamic Acids; D009603:Nitroso Compounds; D010428:Pentosephosphates; D012267:Ribosemonophosphates; C015437:N-phenylglycolhydroxamate; D014174:Transketolase; C012456:nitrosobenzene