Action of 5-(2-thienyl)valeric acid as a biotin antagonist.
5-(2-Thienyl)valeric acid (TVA), a biotin analogue which can be easily prepared through chemical process, inhibited the growth of a biotin synthesizing Rhodotorula glutinis. The growth inhibition was reversed by the addition of biotin. Among biotin intermediates, dethiobiotin and 7,8-diaminopelargonic acid reversed the inhibition by TVA, while 7-keto-8-amino-pelargonic acid and pimelic acid did not. From these results, it was concluded that TVA is a biotin antagonist which probably acts as an inhibitor of biotin biosynthesis.
D001710:Biotin / Q000037:antagonists & inhibitors* / Q000378:metabolism; D010421:Pentanoic Acids / Q000494:pharmacology*; D012248:Rhodotorula / Q000187:drug effects / Q000254:growth & development; D013876:Thiophenes / Q000494:pharmacology; D014631:Valerates / Q000494:pharmacology*
D010421:Pentanoic Acids; D013876:Thiophenes; D014631:Valerates; C015538:5-(2-thienyl)valeric acid; D001710:Biotin