[Inhibition of ultraviolet irradiation response of human skin by topical phlogostatic compounds (author's transl)].
By adaption of the model of UV dermatitis in human skin a test procedure has been developed, which facilitates realistic assessment of topical contrainflammatory activity of steroidal as well as non-steroidal compounds. Six typical skin drug agents exhibited reaction inhibition effects (percent of theoretical maximum) as follows: hydrocortisone = 7%, bufexamac = 11%, oxyphenbutazone = 15%, indometacin = 21%, flumethasone pivalate = 43%, fluocinolone acetonide = 44%.
D002019:Bufexamac / Q000494:pharmacology; D005443:Flumethasone / Q000494:pharmacology; D005446:Fluocinolone Acetonide / Q000494:pharmacology; D006801:Humans; D006854:Hydrocortisone / Q000494:pharmacology; D007213:Indomethacin / Q000494:pharmacology; D010113:Oxyphenbutazone / Q000494:pharmacology; D013471:Sunburn / Q000517:prevention & control*; D013473:Sunscreening Agents / Q000494:pharmacology*; D014466:Ultraviolet Rays
D013473:Sunscreening Agents; D005446:Fluocinolone Acetonide; D002019:Bufexamac; D010113:Oxyphenbutazone; D005443:Flumethasone; D006854:Hydrocortisone; D007213:Indomethacin
Hemmung der Ultraviolettstrahlenreaktion menschlicher Haut durch externe Phlogostatika.