[Controlled study of oral administration of antibiotics in the preparation of digestive surgery (author's transl)].
Between November 30, 1971 and March 15, 1976, 46 patients underwent surgery on the colon or rectum. They were randomized into 2 groups, one receiving a mechanical preparation together with lincomycline, neomycine, polymyxine, kanamycine, bacitracine and nystatine, the other a mechanical preparation alone. Analysis of results reveals no statistically significant difference in the frequency of infections, neither local (11/24 with antibiotics vis 13/22 without; chi2 = 0.25) neither general (16/24 and 9/22; chi2 = 0.92). Nor was the postoperative use of antibiotics for local or general infection different in the 2 groups. No influence of age or preoperative radio-therapy could be shown. This randomized trial suggests that there is little advantage in associating antibiotics to mechanical preparation before colorectal surgery. The authors contemplate a new randomized trial in high-risk patients suffering from cancer.
D000005:Abdomen / Q000601:surgery*; D000284:Administration, Oral; D000328:Adult; D000368:Aged; D000900:Anti-Bacterial Agents / Q000008:administration & dosage* / Q000627:therapeutic use; D003082:Colectomy; D003125:Colostomy; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011183:Postoperative Complications; D011300:Preoperative Care
D000900:Anti-Bacterial Agents
Etude contrôlée de l'administration orale d'antibiotiques comme préparation à la chirurgie digestive.