title: Increased glutathione peroxidase activity in alpha-thalassemia.
abstract: Glutathione peroxidase (GSHPx) activity was found to be greatly elevated in members of a family with alpha-thalassemia. Eleven other families with proven alpha-thalassemia were investigated, and all but one subject with hemoglobin H disease had increased red cell GSHPx. Most persons with alpha-thalassemia trait also had increased activity of red cell GSHPx. In contrast, only very modest increases in glutathione peroxidase activity were observed in subjects with various forms of beta-thalassemia.
mesh_terms: D055598:Chemical Phenomena; D002621:Chemistry; D004592:Electrophoresis, Starch Gel; D005979:Glutathione Peroxidase / Q000097:blood*; D006447:Hemoglobin H; D006801:Humans; D010375:Pedigree; D010544:Peroxidases / Q000097:blood*; D013789:Thalassemia / Q000097:blood* / Q000235:genetics
chemical_list: D006447:Hemoglobin H; D010544:Peroxidases; D005979:Glutathione Peroxidase