Intraocular IgE antibody induced in guinea pigs with Ascaris suum larvae.
The systemic and local (intraocular) IgE antibody responses to infective and heat-killed Ascaris suum larvae were examined in guinea pigs. IgE antibody, demonstrated by the 6-day P-K test, was found in anterior chamber fluid following primary intravitreal injection of live second-stage A. suum larvae and in some instances occurred when no serum P-K activity was demonstrable. No intraocular IgE antibody was induced by primary intravitreal injection of heat-killed larvae. A brisk intraocular and systemic IgE antibody response followed the secondary intravitreal injection of either live or heat-killed larvae into animals systemically infected with A. suum. The guinea pig system promises to be a useful model for studying the immunopathology of human ocular parasite infections.
D000818:Animals; D001082:Aqueous Humor / Q000276:immunology; D001196:Ascariasis / Q000276:immunology*; D001200:Ascaris / Q000276:immunology*; D004195:Disease Models, Animal; D004285:Dogs; D005123:Eye / Q000276:immunology* / Q000473:pathology; D005260:Female; D006168:Guinea Pigs; D006801:Humans; D007073:Immunoglobulin E / Q000032:analysis*; D007814:Larva / Q000276:immunology; D007815:Larva Migrans / Q000276:immunology; D014822:Vitreous Body / Q000276:immunology
D007073:Immunoglobulin E