The mechanism of the inactivation of human fibroblast interferon by mechanical stress.
Interferon derived from human fibroblasts is readily inactivated during agitation and filtration. This inactivation has been shown to be largely a product of mechanical stress, and has been studied in detail by subjecting interferon to controlled shear stress using a rotational viscometer. The possible mechanism of this phenomenon is discussed.
D002460:Cell Line; D003588:Cytopathogenic Effect, Viral / Q000187:drug effects; D004355:Drug Stability; D005347:Fibroblasts; D006801:Humans; D007372:Interferons / Q000096:biosynthesis / Q000494:pharmacology*; D007962:Leukocytes; D008168:Lung / Q000196:embryology; D012845:Sindbis Virus / Q000187:drug effects / Q000254:growth & development; D013314:Stress, Mechanical
D007372:Interferons