title: Effect of thymoanaleptic agents on the course of experimental arterial hypertension and catecholamine content in tissues and urine.
abstract: Experimental hypertension was induced in rats by two methods. In the course of hypertension development the rats of experimental groups were treated with following tricyclic antidepressive agents: Imipramine, Opipramol, Amitriptylline and Nortriptylline injected in doses of 5.0 or 0.5 mg per 1 kg of body weight. Higher doses of the above drugs inhibited the development of hypertension, whereas the lower doses had no effect on arterial blood pressure.
mesh_terms: D000818:Animals; D000928:Antidepressive Agents / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D001011:Aorta / Q000378:metabolism; D001794:Blood Pressure / Q000187:drug effects*; D001923:Brain Chemistry; D002395:Catecholamines / Q000037:antagonists & inhibitors / Q000378:metabolism* / Q000652:urine; D004305:Dose-Response Relationship, Drug; D006339:Heart Rate / Q000187:drug effects; D006973:Hypertension / Q000188:drug therapy* / Q000503:physiopathology; D009206:Myocardium / Q000378:metabolism; D051381:Rats; D014655:Vascular Resistance / Q000187:drug effects
chemical_list: D000928:Antidepressive Agents; D002395:Catecholamines