Rocket propellant inhalation in the Apollo-Soyuz astronauts.
Acute exposure to monomethylhydrazine and dinitrogen tetroxide, the principal toxic irritants in rocket fuels, is described with particular attention to the development of pulmonary edema as a herbinger of more severe central nervous system toxicity. An acute respiratory embarrassment is documented and possible means of therapy based on animal experimental models is suggested. Early clinical and radiographic examination as a baseline for further evaluation is essential, with follow-up radiographs recommended for assessment of possible developing chronic lung disease.
D000328:Adult; D004127:Dimethylhydrazines / Q000009:adverse effects; D006801:Humans; D006834:Hydrazines / Q000009:adverse effects*; D008297:Male; D008875:Middle Aged; D009002:Monomethylhydrazine / Q000009:adverse effects*; D009589:Nitrogen Oxides / Q000009:adverse effects*; D011654:Pulmonary Edema / Q000139:chemically induced* / Q000000981:diagnostic imaging; D011859:Radiography; D013026:Space Flight; D014586:USSR; D014481:United States
D004127:Dimethylhydrazines; D006834:Hydrazines; D009589:Nitrogen Oxides; C015167:nitrogen tetroxide; D009002:Monomethylhydrazine