[Effect of hypothalamic differentation on the functional state of the hypohyseal-adrenal system].
It was shown in experiments on rats that the hypothalamus, isolated from the afferent influences of the overlying structures of the brain, could maintain the ACTH-glucocorticoid secretion at the normal level, but under these conditions there was an increase of its sensitivity to noradrenaline and serotonin, and also to single immobilization; there was also a reduction of the adrenocorticotropic activity of the adenohypophysis and a reduction of the rate of corticosteroid secretion by the adrenal glands into the blood.
D015062:11-Hydroxycorticosteroids / Q000097:blood; D000302:Adrenal Cortex / Q000378:metabolism; D000305:Adrenal Cortex Hormones / Q000097:blood; D000344:Afferent Pathways / Q000502:physiology*; D000818:Animals; D001115:Arecoline / Q000494:pharmacology; D003714:Denervation; D003907:Dexamethasone / Q000494:pharmacology; D006632:Histamine / Q000494:pharmacology; D007031:Hypothalamus / Q000502:physiology*; D007103:Immobilization; D007276:Injections, Intraventricular; D008297:Male; D009638:Norepinephrine / Q000494:pharmacology; D010913:Pituitary-Adrenal System / Q000187:drug effects / Q000502:physiology*; D051381:Rats; D012701:Serotonin / Q000494:pharmacology; D013997:Time Factors
D015062:11-Hydroxycorticosteroids; D000305:Adrenal Cortex Hormones; D012701:Serotonin; D001115:Arecoline; D003907:Dexamethasone; D006632:Histamine; D009638:Norepinephrine
Vliianie deafferentatsii gipotalamusa na funktsional'noe sostoianie gipofizarno-nadpochechnikovoĭ sistemy.