The oestrogenic activity of danazol in the female gerbil (Meriones hurrianae Jerdon).
Antifertility and estrogenic effects of Danazol have been studied in female gerbils. Danazol brings about supression of ovarian weight, presumably by inhibiting gonadotrophin secretion. Enlargement of uterine horns and well defined vaginal keratinization was seen in Danazol treated ovariectomized animals. The results were similar to that of oestradiol dipropionate confirming the oestrogenic activity of Danazol.
D000818:Animals; D002369:Castration; D003613:Danazol / Q000494:pharmacology*; D004958:Estradiol / Q000494:pharmacology; D005260:Female; D005849:Gerbillinae; D006651:Histocytochemistry; D009929:Organ Size / Q000187:drug effects; D010053:Ovary / Q000033:anatomy & histology* / Q000187:drug effects; D011245:Pregnadienes / Q000494:pharmacology*; D014599:Uterus / Q000033:anatomy & histology* / Q000187:drug effects; D014621:Vagina / Q000033:anatomy & histology* / Q000187:drug effects
D011245:Pregnadienes; D004958:Estradiol; D003613:Danazol