Immunotherapy of metastatic cancer in guinea pigs: failure of intralesional BCG to influence the results of radical surgery.
Guinea pigs with growing intradermal transplants of a syngeneic hepatoma treated by intralesional injection of living BCG at a time when lymph node metastases were detectable by palpation were not cured but survived longer than did the controls. Treatment of the animals by excision of the transplant and draining lymph nodes, instead of by BCG, resulted in a significant number of cures. The cure rate of animals receiving both treatments was not demonstrably greater than that obtained in animals receiving surgery alone.
D000818:Animals; D001500:BCG Vaccine / Q000627:therapeutic use*; D006084:Graft Rejection; D006168:Guinea Pigs; D008197:Lymph Node Excision; D008207:Lymphatic Metastasis / Q000628:therapy*; D008297:Male; D009368:Neoplasm Transplantation; D009374:Neoplasms, Experimental / Q000628:therapy; D012878:Skin Neoplasms / Q000276:immunology / Q000628:therapy*; D014185:Transplantation, Isogeneic
D001500:BCG Vaccine