[Effect of adrenaline and acetylcholine on carbohydrate metabolism indices and catecholamine balance in vessel walls].
In tests conducted with cats subject to studies was the influence of epinephrine and acetylcholine, used in various doses, on the level of "key" metabolites of the carbohydrate metabolism and upon the catecholamines content in the vascular walls at the time of the maximum bioelectric and motor responses to the vasomotor agent. It is shown that on administration of a small dose of acetylcholine there supervenes a characteristic redistribution of the study substrates of the carbohydrate metabolism, similar to the one observed after introduction of epinephrine in the same dose. It is suggested that the acetylcholine (1.5 gamma/kg) vasodilation of the blood vessels occurs through mediation of the beta-adrenergic mechanisms. The appearance of changes in the content of carbohydrate metabolites varying in their direction and intensity and occurring under the effect of different acetylcholine doses gives ground to presume the existence of alternative mechanisms accounting for regulation of vasodilatation.
D000109:Acetylcholine / Q000494:pharmacology*; D000818:Animals; D001808:Blood Vessels / Q000187:drug effects* / Q000378:metabolism; D002415:Cats; D002951:Citrates / Q000378:metabolism; D004837:Epinephrine / Q000378:metabolism / Q000494:pharmacology*; D007773:Lactates / Q000378:metabolism; D009638:Norepinephrine / Q000378:metabolism; D011773:Pyruvates / Q000378:metabolism
D002951:Citrates; D007773:Lactates; D011773:Pyruvates; D000109:Acetylcholine; D009638:Norepinephrine; D004837:Epinephrine
Vliianie adrenalina i atsetilkholina na nekotorye pokazateli uglevodnogo obmena i balans katekholaminov v sosudistoĭ stenke.