Stability of [Asu1,7]-eel calcitonin and eel calcitonin in vitro and in vivo.
Stability of [Asu1,7]-eel calcitonin was compared with that of eel calcitonin by the radioimmunoassay method. [Asu1,7]-Eel calcitonin cross-reacted with anti-eel calcitonin antisera. [Asu1,7]-Eel calcitonin was as stable as eel calcitonin in rabbit liver or rabbit kidney extracts when incubated at 37 degrees C. Disappearance curves from the plasma of [Asu1,7]-eel calcitonin and eel calcitonin following iv injection in rabbits were quite similar.
D000818:Animals; D000937:Antigen-Antibody Reactions; D002116:Calcitonin / Q000031:analogs & derivatives / Q000276:immunology; D004355:Drug Stability; D004524:Eels; D006728:Hormones / Q000276:immunology; D007668:Kidney / Q000166:cytology / Q000276:immunology; D008099:Liver / Q000166:cytology / Q000276:immunology; D011817:Rabbits; D011863:Radioimmunoassay
D006728:Hormones; D002116:Calcitonin