title: [An investigation into the levels of a trimethoprim-sulphamethoxazole combination in the ventricular fluid of neurosurgical patients (author's transl)].
abstract: Results of measurements of Trimethoprim-Sulphamethoxazole (Bactrim, Eusaprim) levels in the CSF of seven patients with intact meninges are reported. The maximum fluid concentration of non-protein-bound SMZ was approximately 46.5%. The TMP value was 68.9%. With this combination of drugs it is possible to achieve a high CSF level of broadspectrum chemotherapeutic substances in neurosurgical patients.
mesh_terms: D001812:Blood-Brain Barrier / Q000187:drug effects; D004359:Drug Therapy, Combination; D006801:Humans; D009493:Neurosurgery; D013420:Sulfamethoxazole / Q000008:administration & dosage / Q000097:blood / Q000134:cerebrospinal fluid*; D014295:Trimethoprim / Q000008:administration & dosage / Q000097:blood / Q000134:cerebrospinal fluid*
chemical_list: D014295:Trimethoprim; D013420:Sulfamethoxazole
vernacular_title: Liquorspiegel-Untersuchungen einer Trimethoprim-Sulfamethoxazol-Kombination im Ventrikelliquor bei neurochirurgischen Patienten.