title: The effect of intrauterine fetal transfusion and a beta-sympathomimetic substance on the lecithin/sphingomyelin ratio in human amniotic fluid.
abstract: The apparently low incidence of respiratory distress syndrome in babies born prematurely after intrauterine transfusion and the simultaneous prophylactic administration of intravenous isoxsuprine (a beta-sympathomimetic agent) was investigated by serial study of amniotic fluid lecithin/sphingomyelin ratios. The ratio rose very significantly after intrauterine transfusions and significantly (but less markedly) after the administration of intravenous isoxsuprine alone.
mesh_terms: D000653:Amniotic Fluid / Q000032:analysis / Q000187:drug effects*; D001805:Blood Transfusion, Intrauterine; D004899:Erythroblastosis, Fetal / Q000378:metabolism; D005260:Female; D005865:Gestational Age; D006801:Humans; D007556:Isoxsuprine / Q000494:pharmacology*; D010713:Phosphatidylcholines / Q000032:analysis*; D011247:Pregnancy; D013109:Sphingomyelins / Q000032:analysis*
chemical_list: D010713:Phosphatidylcholines; D013109:Sphingomyelins; D007556:Isoxsuprine