The metabolism of primidone in non-pregnant and 14-day pregnant mice.
1. Non-pregnant and day-14 pregnant mice treated with a single dose of primidone (5 to 150 mg/kg) by gastric intubation were bled at 1 and 4 h after dosage, and the plasma analysed for primidone, phenobarbitone and phenylethylmalondiamide (PEMA) by g.l.c. 2. Marked differences in the rate of metabolism were observed between the non-pregnant and day-14 pregnant mouse. Plasma levels of primidone and PEMA, but not phenobarbitone, were much lower in the day-14 pregnant mouse than in the non-pregnant animal.
D000818:Animals; D005260:Female; D051379:Mice; D010634:Phenobarbital / Q000097:blood; D010657:Phenylethylmalonamide / Q000097:blood; D011247:Pregnancy; D011270:Pregnancy, Animal; D011324:Primidone / Q000097:blood / Q000378:metabolism*; D013723:Teratogens / Q000378:metabolism
D013723:Teratogens; D011324:Primidone; D010657:Phenylethylmalonamide; D010634:Phenobarbital