title: Metabolism of prostaglandin F2alpha in early human placenta in vitro.
abstract: The authors were investigating the metabolism of prostaglandin F2alpha in human early placenta, in in vitro incubation experiments. They have identified both major metabolites, 15-keto-PGF2alpha and 15-keto-13,14 dehydro PGF2alpha. They have examined the change in the percentage of these, taken as a function of time. They have established that the main site of inactivating the endogenous PGF2alpha is the early human placenta. They suppose that the considerable Pg-inactiviting effect of the placenta has a part which acts as a protecting mechanism in preventing the uterotonic influence of the endogenous prostaglandins.
mesh_terms: D005260:Female; D006801:Humans; D066298:In Vitro Techniques; D007700:Kinetics; D010920:Placenta / Q000378:metabolism*; D011247:Pregnancy; D011261:Pregnancy Trimester, First; D011460:Prostaglandins F / Q000378:metabolism*
chemical_list: D011460:Prostaglandins F