Clinical use of a totally heparin grafted hemodialysis system in uremic patients.
1. A totally heparin grafted dialysis system shows great promise in the treatment of chronic uremia associated with bleeding risk. 2. Long-term treatment of chronic uremia with this system has to await: a) Further studies of the chronic toxicity of CPC. b) Evaluation of performance which may be achieved by using a more homogeneous heparin with higher bioactivity. 3. Detailed studies of platelet factor 4 release with subsequent heparin neutralization to determine the importance of this variable in its effect on system performance.
D001778:Blood Coagulation Disorders / Q000517:prevention & control; D001780:Blood Coagulation Tests; D002908:Chronic Disease; D006493:Heparin / Q000009:adverse effects / Q000097:blood; D006801:Humans; D006435:Renal Dialysis; D014511:Uremia / Q000097:blood / Q000628:therapy*
D006493:Heparin