Effect of "3-oxauracil" (2,3-dihydro-1,3-6H-oxazine-dione) in L1210 leukemia.
2.3-Dihydro-1,3-6H-oxazine-dione ("3-oxauracil") was tested against L1210 leukemia. The compound exhibited significant growth-inhibiting effect against this tumor both in vitro and also in vivo following daily intraperitoneal application.
D000818:Animals; D005260:Female; D066298:In Vitro Techniques; D007939:Leukemia L1210 / Q000188:drug therapy*; D051379:Mice; D008811:Mice, Inbred DBA; D010078:Oxazines / Q000008:administration & dosage / Q000378:metabolism / Q000627:therapeutic use*; D013997:Time Factors; D014498:Uracil / Q000031:analogs & derivatives* / Q000378:metabolism / Q000627:therapeutic use
D010078:Oxazines; C015409:3-oxauracil; D014498:Uracil