Medical therapy of experimental infection stones.
Struvite bladder calculi were induced in rats with an intrarenal injection of urease-producing human T mycoplasma strain T960. Acetohydroxamic acid was effective in inhibiting calculous formation. Methylene blue, tetracycline, orthophosphate, diphosphonate, and hydrochlorothiazide had no inhibitory effect.
D000818:Animals; D004164:Diphosphonates / Q000627:therapeutic use; D006852:Hydrochlorothiazide / Q000627:therapeutic use; D006877:Hydroxamic Acids / Q000627:therapeutic use; D008297:Male; D008751:Methylene Blue / Q000627:therapeutic use; D009174:Mycoplasma; D010710:Phosphates / Q000627:therapeutic use; D051381:Rats; D013752:Tetracycline / Q000627:therapeutic use; D001744:Urinary Bladder Calculi / Q000188:drug therapy* / Q000209:etiology
D004164:Diphosphonates; D006877:Hydroxamic Acids; D010710:Phosphates; D006852:Hydrochlorothiazide; C006358:acetohydroxamic acid; D013752:Tetracycline; D008751:Methylene Blue