The effects of chronic administration of cyclophosphamide on haemopoietic stem cells.
The effects of cyclophosphamide given for 18 weeks in small daily doses on CFU-S, CFU-C, and CFU-E content in mice bone marrow and spleen were studied. In the bone marrow, after an initial drop, the stem cell content rises above the normal values and remains there throughout a long period. In the spleen the stem cell content shows an initial several fold increase followed by a steady decline. It seems possible that this behaviour reflects a compensative effect to the toxic action of the drug at more differentiated levels of the haemopoietic cells.
D000818:Animals; D001772:Blood Cell Count; D001853:Bone Marrow / Q000187:drug effects; D001854:Bone Marrow Cells; D002455:Cell Division / Q000187:drug effects; D003520:Cyclophosphamide / Q000008:administration & dosage / Q000494:pharmacology*; D005260:Female; D006412:Hematopoietic Stem Cells / Q000187:drug effects*; D008297:Male; D051379:Mice; D008809:Mice, Inbred C3H; D008810:Mice, Inbred C57BL; D013154:Spleen / Q000166:cytology / Q000187:drug effects; D013997:Time Factors
D003520:Cyclophosphamide