Blood glucose control and glomerular capillary basement membrane thickening in experimental diabetes.
Glomerular capillary basement membrane thickness (BMT) was measured in 23 rats which had had streptozocin-induced diabetes for 14 months and in 12 age-matched controls. Diabetic rats were randomly allocated to different groups, either receiving no treatment or treated with a low carbohydrate diet or insulin, or both. Control rats were randomly allocated to a normal or low carbohydrate diet. Among the diabetic rats mean plasma glucose concentrations for the groups ranged from 27-4 mmol/l (494 mg/100 ml) in the untreated rats to 9-8 mmol/l (177 mg/100 ml) in those receiving both a low carbohydrate diet and insulin. A highly significant positive relation was found between BMT and plasma glucose concentration for individual rats. When BMT was corrected for body weight a similar relation was observed.
D000818:Animals; D001485:Basement Membrane / Q000473:pathology; D001786:Blood Glucose; D001835:Body Weight; D002196:Capillaries / Q000473:pathology; D003921:Diabetes Mellitus, Experimental / Q000097:blood / Q000473:pathology*; D003925:Diabetic Angiopathies / Q000473:pathology; D004040:Dietary Carbohydrates / Q000008:administration & dosage; D007328:Insulin / Q000008:administration & dosage; D007678:Kidney Glomerulus / Q000473:pathology*; D008297:Male; D051381:Rats
D001786:Blood Glucose; D004040:Dietary Carbohydrates; D007328:Insulin