Rapid, sensitive gas-liquid chromatographic method for determination of amitryptyline and nortriptyline in plasma using a nitrogen-sensitive detector.
A simple gas chromatographic method for determination of amitriptyline and nortriptyline in plasma using a nitrogen-sensitive detector is described. Concentrations of both drugs as low as 10 ng per ml plasma were measured. The precision and accuracy of the method are within acceptable limits.
D000639:Amitriptyline / Q000097:blood*; D002849:Chromatography, Gas / Q000379:methods; D006801:Humans; D007202:Indicators and Reagents; D008832:Microchemistry; D009584:Nitrogen; D009661:Nortriptyline / Q000097:blood*; D013329:Structure-Activity Relationship
D007202:Indicators and Reagents; D000639:Amitriptyline; D009661:Nortriptyline; D009584:Nitrogen