Carcinogenic activity of 2-(2-furyl)-3-(5-nitro-2-furyl)-acrylamide, a food additive, in mice and rats.
The carcinogenicity of a food additive, 2-(2-furyl)-3-(5-nitro-2-furyl)acrylamide (AF-2), was studied in Wistar rats and CDF1 mice. The rats developed mammary tumors; the first appearing 9 months after the start of the experiment. In mice fed AF-2 diet, squamous cell carcinoma of the forestomach was observed in the 11th month. Some mice had metastases in the liver, spleen, lymph nodes and peritoneal cavity.
D000230:Adenocarcinoma / Q000139:chemically induced; D000818:Animals; D002273:Carcinogens; D002294:Carcinoma, Squamous Cell / Q000139:chemically induced; D005260:Female; D005503:Food Additives / Q000009:adverse effects*; D005668:Furylfuramide / Q000009:adverse effects*; D008297:Male; D008325:Mammary Neoplasms, Experimental / Q000139:chemically induced; D051379:Mice; D009374:Neoplasms, Experimental / Q000139:chemically induced*; D009581:Nitrofurans / Q000009:adverse effects*; D010212:Papilloma / Q000139:chemically induced; D051381:Rats; D013274:Stomach Neoplasms / Q000139:chemically induced
D002273:Carcinogens; D005503:Food Additives; D009581:Nitrofurans; D005668:Furylfuramide