Prostaglandins and congeners. 14. Synthesis and bronchodilator activity of dl-16,16-trimethyleneprostaglandins.
The interesting bronchodilator activity of novel dl-16,16-trimethyleneprostaglandin congeners and their preparation via the conjugate addition of the appropriate vinyl lithiocuprate reagent to several cyclopentenones are described. Also discussed is the preparation of the key intermediate vinyl iodine 7.
D000109:Acetylcholine / Q000494:pharmacology; D000818:Animals; D001986:Bronchial Spasm / Q000139:chemically induced / Q000503:physiopathology; D001993:Bronchodilator Agents / Q000138:chemical synthesis*; D005260:Female; D006632:Histamine / Q000494:pharmacology; D008297:Male; D051379:Mice; D011458:Prostaglandins E / Q000138:chemical synthesis / Q000494:pharmacology; D011465:Prostaglandins, Synthetic / Q000138:chemical synthesis* / Q000494:pharmacology; D012701:Serotonin / Q000494:pharmacology
D001993:Bronchodilator Agents; D011458:Prostaglandins E; D011465:Prostaglandins, Synthetic; D012701:Serotonin; D006632:Histamine; D000109:Acetylcholine