Effect of sexual steroid hormones and of clomiphene on the behavioral response to L-dopa in mice.
The scope of the present work was to ascertain the effects of some steroid hormones on the behavioral response of mice to L-Dopa. The drugs considered were: testosterone, mesterolone, cyproterone, estradiol, progesterone and clomiphene. The male sex steroids, having either androgen or antiandrogen properties, were able to potentiate the behavioral effect of L-Dopa in mice, while female sex steroids failed to demonstrate this activity. Clomiphene proved to be the most active in enhancing the behavioral effects of L-Dopa in mice.
D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects*; D002996:Clomiphene / Q000494:pharmacology*; D003534:Cyproterone / Q000494:pharmacology; D004347:Drug Interactions; D004958:Estradiol / Q000494:pharmacology; D012739:Gonadal Steroid Hormones / Q000494:pharmacology*; D007980:Levodopa / Q000494:pharmacology*; D008297:Male; D008655:Mesterolone / Q000494:pharmacology; D051379:Mice; D010293:Pargyline / Q000494:pharmacology; D011374:Progesterone / Q000494:pharmacology; D012997:Solvents / Q000494:pharmacology; D013739:Testosterone / Q000494:pharmacology
D012739:Gonadal Steroid Hormones; D012997:Solvents; D008655:Mesterolone; D002996:Clomiphene; D013739:Testosterone; D007980:Levodopa; D011374:Progesterone; D004958:Estradiol; D010293:Pargyline; D003534:Cyproterone