4-Substituted semicarbazones of mono- and dichlorobenzaldehydes as antihypertensive agents.
Twelve 4-substituted semicarbazone derivatives of o- and p-chloro- as well as 2,6-dichlorobenzaldehyde were synthesized and investigated for antihypertensive activity in spontaneously hypertensive rats. Several of the compounds synthesized (viz. 1, 6, 7, and 15) exhibited potent antihypertensive effects when orally administered. The same compounds were not hypotensive in the normotensive dog.
D000818:Animals; D000959:Antihypertensive Agents / Q000138:chemical synthesis* / Q000627:therapeutic use; D001547:Benzaldehydes / Q000138:chemical synthesis* / Q000627:therapeutic use; D004285:Dogs; D006973:Hypertension / Q000188:drug therapy; D051381:Rats; D012664:Semicarbazones / Q000138:chemical synthesis / Q000627:therapeutic use; D013329:Structure-Activity Relationship
D000959:Antihypertensive Agents; D001547:Benzaldehydes; D012664:Semicarbazones