title: T1Wh, a promising mouse strain with chromosomal markers for cleft palate research.
abstract: Attainment of the horizontal position by the secondary palatal shelves and fusion in relationship to morphological and chronological ages in T1Wh, and albino strain of mice homozygous for a 5;19 Robertsonian translocation, was found to be late and slow in comparison to other strains previously investigated. Spontaneous and cortisone-induced cleft palate frequencies of 3.5% and 100% respectively, were found in this strain. Its slow and late palatal closure, high susceptibility to cortisone, obvious marker chromosomes, and good breeding performance promise to make T1Wh a useful strain for cleft palate research.
mesh_terms: D000014:Abnormalities, Drug-Induced; D000818:Animals; D002869:Chromosome Aberrations; D002972:Cleft Palate / Q000139:chemically induced*; D003348:Cortisone / Q000009:adverse effects*; D005260:Female; D051379:Mice; D008815:Mice, Inbred Strains / Q000033:anatomy & histology*; D011247:Pregnancy; D014178:Translocation, Genetic
chemical_list: D003348:Cortisone