[Radiotherapy of lymphogranulomatosis--relations between radiomyelitis and oncogenic alteration of the spinal marrow (author's transl)].
The authors compare the results of two methods of the upper and lower system irradiation in case of Hodgkin's disease with respect to the spinal marrow. The frequency of radiomyelitis is opposed to the frequency of Hodgkin-specific alterations of the spinal marrow. 74 patients were submitted to telecobalt irradiations the dosage of which was below the tolerances known for the spinal marrow. Two of them presented a radiomyelitis and two a paraplegia of Hodgkin in the irradiated region. One paraplegia caused by the formation of a tumor developed in a region next to the irradiation field; certainly this region would have been affected by a higher dosed large-field irradiation of the spinal marrow. The application of the large-field methods in 61 patients did not cause any radiomyelitis in spite of doses which were higher than the tolerance doses for the spinal marrow of Franke. Hodgkin- specific infiltrations of the spinal canal were also not observed. The large-field method can also be recommended because it seems to offer a larger therapeutic field between the risks of spinal Hodgkin manifestations and radiomyelitis.
D000328:Adult; D003037:Cobalt Radioisotopes / Q000627:therapeutic use; D005260:Female; D006689:Hodgkin Disease / Q000532:radiotherapy*; D006801:Humans; D008297:Male; D008722:Methods; D008875:Middle Aged; D009187:Myelitis / Q000209:etiology*; D009362:Neoplasm Metastasis; D010264:Paraplegia / Q000209:etiology; D011832:Radiation Injuries / Q000209:etiology*; D011867:Radioisotope Teletherapy; D011878:Radiotherapy / Q000009:adverse effects; D011879:Radiotherapy Dosage; D013125:Spinal Neoplasms / Q000150:complications
D003037:Cobalt Radioisotopes
Zur Strahlentherapie der Lymphogranulomatose--Beziehungen zwischen Strahlenmyelitis und tumoröser Rückenmarksalteration.