[Effect of non-radioactive thymidine on mitosis in bone marrow].
Intraperitoneal administration of thymidine into albino mouse (strains CD-1) at dose of 4.8 mg (180 mg/kg) increases mitotic rate in bone marrow at 6, 9 and 12 hours; this effect begins at 3 hours and disappears at 24 hours. It is suggested that thymidine increases mitotic rate by an indirect mechanism, stimulating DNA synthesis during S phase through activation of thymidoquinase. Control group (saline solution without thymidine) showed reduction in mitotic rate; such a finding has no explanation as yet.
D000818:Animals; D001853:Bone Marrow / Q000187:drug effects*; D004247:DNA / Q000096:biosynthesis; D008938:Mitosis / Q000187:drug effects*; D051381:Rats; D013936:Thymidine / Q000494:pharmacology*; D013937:Thymidine Kinase / Q000494:pharmacology
D004247:DNA; D013937:Thymidine Kinase; D013936:Thymidine
Efecto de la timidina no radiactiva en la mitosis de médula ósea.