Recovery of amnestic effect of alpha-amanitin by post-training administration of d-amphetamine in the rat.
alpha-Amanitin, an inhibitor of RNA polymerase II, given intraventricularly 6 or 24 h before training, impaired consolidation of both passive and active avoidance responses in rats. Administration of d-amphetamine sulfate (0.5 mg/kg intraperitoneally) immediately after training produced a clear-cut antiamnestic effect in alpha-amanitin-injected rats without modifying consolidation in control animals. Examination of several parameters of conditioning enabled the authors to rule out an impairment in locomotor performance of alpha-amanitin-treated rats both in training and in test sessions. The amnestic effect of alpha-amanitin and recovery by means of d-amphetamine were discussed in relation to RNA synthesis inhibition and a possible restoring effect of d-amphetamine upon alpha-amanitin-induced decrease of brain RNA content.
D000546:Amanitins / Q000037:antagonists & inhibitors*; D000818:Animals; D001362:Avoidance Learning / Q000187:drug effects*; D003213:Conditioning, Psychological / Q000187:drug effects; D003913:Dextroamphetamine / Q000494:pharmacology*; D006624:Hippocampus / Q000187:drug effects; D008297:Male; D008568:Memory / Q000187:drug effects*; D009419:Nerve Tissue Proteins / Q000096:biosynthesis; D012313:RNA / Q000096:biosynthesis; D051381:Rats
D000546:Amanitins; D009419:Nerve Tissue Proteins; D012313:RNA; D003913:Dextroamphetamine