[Concordant medullary thyroid carcinoma in identical twins with discordant phaeochromocytoma (Sipple syndrome) (author's transl)].
The first case of Sipple syndrome in identical twins is reported. It is concluded that the concordant medullary carcinoma of the thyroid is the result of a germinal mutation, whilst the discordant solitary phaeochromocytoma is caused by a somatic mutation according to the two mutation model. The practical conclusion to be drawn from this report is that if one identical twin develops carcinoma of the thyroid or a phaeochromocytoma, the other twin should be throughly investigated and surgical exploration undertaken, even in the absence of clinical evidence of disease.
D000328:Adult; D004200:Diseases in Twins; D005260:Female; D006801:Humans; D008297:Male; D010282:Parathyroid Neoplasms / Q000175:diagnosis* / Q000235:genetics / Q000473:pathology; D010673:Pheochromocytoma / Q000175:diagnosis* / Q000235:genetics / Q000473:pathology; D013577:Syndrome; D013964:Thyroid Neoplasms / Q000175:diagnosis* / Q000235:genetics / Q000473:pathology
Konkordantes medulläres Schilddrüsenkarzinom bei eineiigen Zwillingen mit diskordantem Phäochromozytom (Sipple-Syndrom).