title: Plasma, bone, hip capsule, synovial and drain fluid concentrations of lincomycin during total hip replacement.
abstract: 1 Lincomycin (600 mg) was given 6 h preoperatively by intramuscular injection, as an intravenous infusion over 30 min and for 72 h postoperatively in twelve patients having total hip replacement. 2 The plasma, bone, hip capsule, synovial and drain fluid concentrations of lincomycin were almost always above the M.I.C. of lincomycin against penicillinase producing Staphylococcus aureus. 3 There was a good correlation between the estimated concentrations of lincomycin in bone by the grinding and agitation methods of analysis. 4 Two patients developed pseudomembranous colitis after parenteral lincomycin.
mesh_terms: D000328:Adult; D000368:Aged; D001826:Body Fluids / Q000378:metabolism*; D001842:Bone and Bones / Q000378:metabolism*; D005260:Female; D006621:Hip Joint / Q000378:metabolism / Q000601:surgery*; D006801:Humans; D008034:Lincomycin / Q000097:blood / Q000378:metabolism* / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged; D013530:Surgical Wound Infection / Q000517:prevention & control; D013582:Synovial Fluid / Q000378:metabolism*; D013997:Time Factors
chemical_list: D008034:Lincomycin