title: [Effects of fractionated whole body X-irradiation on the CNS of fetal mouse. Topographic and quantitative micromorphologic characterisation (author's transl)].
abstract: Whole body X-irradiation of pregnant NMRI-mice between day 11--13 after conception results in pathological morphogenesis of the CNS. These effects are reduction of dimensions of forebrain, desorganisation of structure and occurrence of spherical cell arrangements, the so called rosettes. These can be especially found in dorsal parts of the hemispheres and have been registered qualitatively by its number and dimension in the dose range between 3 X 110 R and 3 X 120 R. A clear correlation between the number of rosettes and the reduction of thickness of the hemisphere-walls can be demonstrated. These results will be fundamental for further studies concerning with reparation processes of the irradiation damage in postnatal stages.
mesh_terms: D000818:Animals; D001921:Brain / Q000002:abnormalities* / Q000473:pathology / Q000528:radiation effects; D005260:Female; D051379:Mice; D011247:Pregnancy; D011829:Radiation Dosage; D011833:Radiation Injuries, Experimental / Q000473:pathology*; D013997:Time Factors
vernacular_title: Missbildungen des ZNS fetaler Mäuse nach fraktionierter Ganzkörper-Röntgenbestrahlung, Topographische und quantitative mikromorphologische Charakterisierung.