[The effect of gamma-OH on cerebral metabolism and blood flow in human patients (author's transl)].
The effects of gamma-OH on cerebral blood flow (CBF) and metabolism were analysed in 10 neurosurgical patients, 15 min after a 60 mg/kg injection, both blood flow and oxygen consumption demonstrates a disconnection between blood flow and metabolism which appears an advantage and hence the interest in using this agent in anaesthesia and neurosurgical intensive care. 1 h40 min later no rebound effect was found; the metabolic reduction persisted whereas the CBF had returned to its resting level. Under gamma-OH CO2 production does not parallel O2 consumption and this could be interpreted as a sign that glucose-6-phosphate is metabolising via pentose.
D000293:Adolescent; D000328:Adult; D000368:Aged; D001921:Brain / Q000187:drug effects / Q000378:metabolism*; D002245:Carbon Dioxide / Q000378:metabolism; D002560:Cerebrovascular Circulation / Q000187:drug effects*; D005260:Female; D005947:Glucose / Q000378:metabolism; D006801:Humans; D006885:Hydroxybutyrates / Q000494:pharmacology*; D008297:Male; D008875:Middle Aged; D010101:Oxygen Consumption / Q000187:drug effects; D013997:Time Factors
D006885:Hydroxybutyrates; D002245:Carbon Dioxide; D005947:Glucose
Action du gamma-OH sur le métabolisme et le début cérébral en clinique humaine.