Renal venous output of kinins in patients with hypertension and unilateral renal artery stenosis.
In four patients with hypertension and angiographically pronounced unilateral renal artery stenosis, kallikrein activity was estimated in each kidney separately by the determination of kinin output in the renal veins. All patients showed suppression of renin release from the kidney with a non-stenotic artery. Accordingly, plasma flow from the kidney with artery stenosis could be estimated. The ratio of venous output of kinins between the kidney with a non-stenotic artery and the one with artery stenosis was 2.6-6.5. This indicates that renal artery stenosis leads to diminished intrarenal kinin generation. Reduced kinin formation may explain the low diuresis and natriuresis found in the kidney with artery stenosis.
D000328:Adult; D005260:Female; D006801:Humans; D006977:Hypertension, Renal / Q000378:metabolism*; D007610:Kallikreins / Q000378:metabolism*; D007668:Kidney / Q000098:blood supply / Q000378:metabolism*; D007705:Kinins / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D012078:Renal Artery Obstruction / Q000378:metabolism*; D012083:Renin / Q000378:metabolism
D007705:Kinins; D007610:Kallikreins; D012083:Renin