The mode of action of aescin and the release of prostaglandins.
The horse-chestnut saponin Aescin, an anti-exudative compound, induces contraction of isolated portal vein of rat and rabbit. This effect appears to be mediated by Prostaglandins of Falpha type. The ability of Aescin to stimulate generation and release of Prostaglandins has been demonstrated in isolated lung of the rat. Mass-fragmentographic analysis of the lung effluent indicate that when Aescin is perfused through this organ the release of PGF2alpha is increased. The capability of Aescin to generate Prostaglandins is discussed in connection with its anti-exudative activity.
D000818:Animals; D004928:Escin / Q000494:pharmacology*; D008168:Lung / Q000378:metabolism; D008297:Male; D009119:Muscle Contraction / Q000187:drug effects; D009130:Muscle, Smooth / Q000187:drug effects; D010477:Perfusion; D011169:Portal Vein / Q000187:drug effects; D011460:Prostaglandins F / Q000378:metabolism*; D011817:Rabbits; D051381:Rats; D011919:Rats, Inbred Strains; D012503:Saponins / Q000494:pharmacology*; D012636:Secretory Rate / Q000187:drug effects
D011460:Prostaglandins F; D012503:Saponins; D004928:Escin