Microbial transformations of natural antitumor agents. IV. Formation of N-(2)-nor-d-tetrandrine by Cunninghamella blakesleeana (ATCC 8688a).
Microbial transformation experiments have been conducted with the antitumor alkaloid, d-tetrandrine. The alkaloid is selectively demethylated at the N-(2)-position by Cunninghamella blakesleeana ATCC 8688a. The biotransformation reaction is highly selective and uncomplicated by side-product formation. N-demethylation of the alkaloid using methylchloroformate is not regio-specific. Procedures used in screening microorganisms for their abilities to yield metabolites of d-tetrandrine are evaluated.
D000470:Alkaloids / Q000378:metabolism*; D000972:Antineoplastic Agents, Phytogenic / Q000378:metabolism*; D044182:Benzylisoquinolines; D005658:Fungi / Q000378:metabolism*; D007546:Isoquinolines / Q000378:metabolism*; D009682:Magnetic Resonance Spectroscopy; D008968:Molecular Conformation; D009090:Mucorales / Q000378:metabolism*; D013045:Species Specificity; D013329:Structure-Activity Relationship
D000470:Alkaloids; D000972:Antineoplastic Agents, Phytogenic; D044182:Benzylisoquinolines; D007546:Isoquinolines; C015400:N-(2)-nor-d-tetrandrine