Diallylnitrosamine: a potent respiratory carcinogen in Syrian golden hamsters: brief communication.
Diallylnitrosamine (DAN), one of the few nitrosamines tested thus far that has not induced neoplasms in rats, caused a high incidence of respiratory tract tumors in Syrian golden hamsters treated sc with single or weekly doses of the compound. The effect was dose-dependent. The nasal cavity, larynx, and trachea were the most affected by DAN; most drug-induced tumors at those sites were adenocarcinomas and papillary polyps.
D000818:Animals; D002273:Carcinogens; D006224:Cricetinae; D005260:Female; D007822:Laryngeal Neoplasms / Q000139:chemically induced; D008297:Male; D008647:Mesocricetus; D009296:Nasal Cavity; D009374:Neoplasms, Experimental / Q000139:chemically induced; D009602:Nitrosamines / Q000008:administration & dosage / Q000633:toxicity; D009669:Nose Neoplasms / Q000139:chemically induced; D051381:Rats; D012142:Respiratory Tract Neoplasms / Q000139:chemically induced*; D013045:Species Specificity; D014134:Tracheal Neoplasms / Q000139:chemically induced
D002273:Carcinogens; D009602:Nitrosamines; C015125:diallylnitrosamine