Autoimmune hemolytic anemia with anti Jka specificity in a patient taking aldomet.
Autoimmune hemolytic anemia (hemoglobin 5.2 g, reticulocyte count 31.0 per cent) developed in a 53-year-old hypertensive woman who was taking Aldomet. Both the patient's serum and the eluate prepared from her red blood cells contained an antibody with anti-Jka specificity. Rapid sustained improvement in the anemia occurred after cessation of Aldomet and a two week course of prednisone therapy. Eight months later, anti-Jka was no longer detectable in the patient's serum and the direct antiglobulin test was nonreactive.
D000373:Agglutinins; D000744:Anemia, Hemolytic, Autoimmune / Q000097:blood / Q000139:chemically induced*; D001789:Blood Group Antigens; D005260:Female; D006801:Humans; D007667:Kidd Blood-Group System; D008750:Methyldopa / Q000009:adverse effects*; D008875:Middle Aged
D000373:Agglutinins; D001789:Blood Group Antigens; D007667:Kidd Blood-Group System; D008750:Methyldopa