Failure of pyridoxine to improve glucose tolerance in gestational diabetes mellitus.
Intrigued by the potential simplicity and far-reaching benefits of the amelioration or prevention of gestational diabetes mellitus by pyridoxine, as reported by others, an attempt to confirm this effect was made. No beneficial effects on abnormal glucose tolerance in pregnancy was demonstrated in 4 cases studied. It is likely that the dietary alterations made during pyridoxine therapy in the previous report had a greater effect on outcome than the authors had suspected. The failure to confirm their results was statistically significant (P = 0.005).
D000328:Adult; D005260:Female; D005947:Glucose / Q000378:metabolism*; D005951:Glucose Tolerance Test; D006801:Humans; D007408:Intestinal Absorption / Q000187:drug effects; D011247:Pregnancy; D011254:Pregnancy in Diabetics / Q000188:drug therapy* / Q000517:prevention & control; D011736:Pyridoxine / Q000494:pharmacology / Q000627:therapeutic use*
D005947:Glucose; D011736:Pyridoxine