Urinary hydroxyproline concentration in primary hyperparathyroidism with and without renal stones.
Eleven cases with histologically confirmed primary hyperparathyroidism have been studied. Although histologically, bone turnover increased in all but 1 patient, urinary hydroxyproline excretion and serum alkaline phosphatase in patients with renal stones were within the upper normal limits of slightly elevated (27.5 mg/24 h, concentration 19.5 microgram/ml, alkaline phosphatase 35.0 IU/l). On the contrary, 3 cases without renal stones exhibited an increased urinary hydroxyproline excretion (129 mg/24 h, concentration 95.6 microgram/ml) and elevated serum alkaline phosphatase (99.9IU/l). Serum total hydroxyproline was elevated in both groups (renal stones, 2.00 mg%; no renal stones, 3.16 mg%; p = 0.006). Hydroxyproline was determined under conditions of a very low proline diet and 1.5 liters of daily fluid intake. There were no statistically significant differences between serum calcium, phosphorus, and parathormone between urinary excretion of calcium and phosphorus. Creatinine clearance was within normal limits in all patients. The possible relevance of urinary hydroxyproline for stone formation is discussed.
D000328:Adult; D000469:Alkaline Phosphatase / Q000097:blood; D002118:Calcium / Q000378:metabolism; D003404:Creatinine / Q000378:metabolism; D005260:Female; D006801:Humans; D006909:Hydroxyproline / Q000097:blood / Q000652:urine*; D006961:Hyperparathyroidism / Q000150:complications / Q000201:enzymology / Q000378:metabolism*; D007669:Kidney Calculi / Q000201:enzymology / Q000209:etiology* / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D010758:Phosphorus / Q000378:metabolism
D010758:Phosphorus; D003404:Creatinine; D000469:Alkaline Phosphatase; D006909:Hydroxyproline; D002118:Calcium