[Comparative study of the antiviral activity of rimantadine and bonafton].
The results of the study on toxicity and the antiviral activity of bonaphthone and rimantadine are presented. A high toxicity of bonaphthone for developing chick embryos was demonstrated, the maximum non-toxic dose of bonaphthone being about 10 microgram/embryo, while for rimantadine it was above 1000 microgram/embryo. In white mice, however, the toxicity of these two drugs was approximately similar. The minimal single lethal dose for mice by the oral route was 400-500 mg/kg for rimantadine and bonaphthone, by the intraperitoneal route 65 mg/kg for bonaphthone and 125 mg/kg for rimantadine. Bonaphthone had a slight prophylactic activity protecting mice inoculated with A2/Bethesda/63 influenza virus. The index of effectiveness of bonaphthone was about 40%, that of rimantadine under similar experimental conditions over 90%. Bonaphthone had no therapeutic effect. It inhibited multiplication of A2/Hong Kong/68 influenza virus in the lungs of mice inoculated with minimal doses of the virus, but was inactive in case of infection of mice with A/Port Chalmers/73 virus. Thus, the comparative study of bonaphthone and rimantadine revealed no superiority of bonaphthone.
D000218:Adamantane / Q000031:analogs & derivatives / Q000627:therapeutic use*; D000547:Amantadine / Q000627:therapeutic use; D000818:Animals; D000998:Antiviral Agents / Q000494:pharmacology / Q000627:therapeutic use* / Q000633:toxicity; D001952:Bridged-Ring Compounds / Q000627:therapeutic use*; D002642:Chick Embryo; D009980:Influenza A virus / Q000187:drug effects*; D051379:Mice; D009285:Naphthoquinones / Q000627:therapeutic use*; D009976:Orthomyxoviridae Infections / Q000517:prevention & control / Q000628:therapy*
D000998:Antiviral Agents; D001952:Bridged-Ring Compounds; D009285:Naphthoquinones; D000547:Amantadine; D000218:Adamantane
Sravnitel'noe izuchenie protivovirusnoĭ aktivnosti rimantadina i bonaftona.