[Effect of carbamazepine on free and protein-bound tryptophan in the blood of epileptic patients and healthy volunteers].
The Authors estimated the influence of carbamazepine on both free and linked albumin triptofane in the plasma of 6 epileptic patients and of 6 healthy volunteers, during a period of observation lasting 7 days. The relation free/linked triptofane decreased significantly in the epileptic patients after the first day of treatment, while an analogous phenomenon was observed in healthy people only after the seventh day. Part of triptofane disappeared from plasma thus suggesting a cerebral uptake of the synthesis of serotonin. Carbamazepine displaced some unknown compounds from their links with plasmatic albumin, thus allowing triptofane to link itsel. The Authors therefore confirm the role played by anticonvulsive drugs in modifying the pool of free aminoacids in plasma.
D000293:Adolescent; D000328:Adult; D002220:Carbamazepine / Q000494:pharmacology*; D004827:Epilepsy / Q000097:blood*; D005260:Female; D006801:Humans; D008297:Male; D011485:Protein Binding; D014364:Tryptophan / Q000097:blood*
D002220:Carbamazepine; D014364:Tryptophan
Influenza della carbamazepina sul triptofano libero e legato alle proteine nel plasma di pazienti epilettici e volontari sani.