Uricosuric effects of niridazole.
Niridazole, an antischistosomal drug, caused a 44% decrease in the serum uric acid (SUA) concentration in 11 patients with schistosomiasis. The mean SUA (+/- SE) was 6.3 +/- 1.4 mg/100 ml at baseline and 3.5 +/- 1.5 mg/100 ml (p less than 0.01) on day 7 of treatment. There was a significant increase in the urinary uric acid/creatinine ratio, from 0.446 +/- 0.165 at baseline to 0.550 +/- 0.145 on day 3. There was no significant difference on day 7. The fractional clearance of uric acid rose from 7.2 +/- 6.8% to 13.9 +/- 17.3% (p less than 0.01), indicating a uricosuric effect. Oxypurine excretion was unchanged. In a separate study on 7 other patients, the SUA remained low for 4 to 7 days after the last dose. Niridazole, although not an organic acid, has uricosuric effects.
D003404:Creatinine / Q000652:urine; D003864:Depression, Chemical; D006801:Humans; D009560:Niridazole / Q000494:pharmacology*; D013997:Time Factors; D014527:Uric Acid / Q000097:blood / Q000652:urine; D014528:Uricosuric Agents
D014528:Uricosuric Agents; D014527:Uric Acid; D003404:Creatinine; D009560:Niridazole