title: Efficacy of herpesvirus of turkeys vaccine against challenge with Marek's disease tumor cells.
abstract: Tests were made of the effectiveness of herpesvirus of turkeys (HVT) vaccine in preventing tumorigenesis following challenge with a neoplastically transformed Marek's disease tumor cell line (MSB-1). HVT vaccine prevented tumors due to MSB-1 inoculation whereas 21.4% of unvaccinated controls had tumors. The results support, but do not prove, the theory that HVT acts through enhancement of cell-mediated immunity against MDV-transformed cells. The drawbacks of using MSB-1 cells in this experiment and the need for true Marek's transplantable tumor cells are discussed.
mesh_terms: D000818:Animals; D002471:Cell Transformation, Neoplastic; D002645:Chickens; D006564:Herpesviridae / Q000276:immunology*; D008380:Marek Disease / Q000276:immunology / Q000473:pathology / Q000517:prevention & control*; D014422:Turkeys; D014765:Viral Vaccines
chemical_list: D014765:Viral Vaccines