Effect of cyclophosphamide on interstitial nephritis and tubule cell proliferation in NZB/NZE mice.
The effect of cyclophosphamide on renal interstitial mononuclear cell infiltration and renal tubule cell (TC) proliferation has been examined in (NZB x NZW)F1 hybrid (B/W) and control mice. TC proliferation was measured by tritiated thymidine (3/Tdr) injection, autoradiographic examination of kidney sections, and enumeration of labeled tubular cells. Cyclophosphamide administered 2 months before sacrifice virtually obliterated interstitial infiltration and significantly decreased tubule cell proliferation at 3, 5, 7, 9, and 12 months of age.
D000375:Aging; D000818:Animals; D002455:Cell Division / Q000187:drug effects; D003433:Crosses, Genetic; D003520:Cyclophosphamide / Q000627:therapeutic use*; D005260:Female; D007668:Kidney / Q000473:pathology; D007684:Kidney Tubules / Q000166:cytology / Q000187:drug effects*; D051379:Mice; D008814:Mice, Inbred NZB; D009395:Nephritis, Interstitial / Q000188:drug therapy*
D003520:Cyclophosphamide