Study of two different subpopulations of anti-acetylcholine receptor antibodies in a rabbit with experimental auto-immune myasthenia gravis.
Two different subpopulations of anti-acetylcholine receptor antibodies were studied during the evolution of experimental autoimmune myasthenia in one rabbit immunized with Torpedo acetylcholine receptor. The results show that the subpopulation of antibodies directed against the toxin-binding site of the receptor might play a role in the appearance of the paralysis observed in this particular case.
D000109:Acetylcholine / Q000378:metabolism*; D000818:Animals; D000906:Antibodies; D000917:Antibody Formation; D001327:Autoimmune Diseases / Q000276:immunology*; D003964:Diaphragm / Q000276:immunology; D004546:Elapid Venoms / Q000276:immunology; D007106:Immune Sera / Q000494:pharmacology; D051379:Mice; D008809:Mice, Inbred C3H; D009157:Myasthenia Gravis / Q000276:immunology*; D011817:Rabbits; D011950:Receptors, Cholinergic / Q000276:immunology*
D000906:Antibodies; D004546:Elapid Venoms; D007106:Immune Sera; D011950:Receptors, Cholinergic; D000109:Acetylcholine