Toxicity of Callilepis laureola.
Callilepis laureola, which has been found to cause fatal liver necrosis in the Black population of Natal, is widely used as a herbal medicine. Chemical extraction has yielded a product, identified as atractyloside, which is responsible for the nephrotoxic and hypoglycaemic effects of Callilepis laureola. The hepatotoxic principle has not yet been isolated.
D000818:Animals; D001278:Atractyloside / Q000302:isolation & purification / Q000633:toxicity; D056486:Chemical and Drug Induced Liver Injury / Q000209:etiology; D007683:Kidney Tubular Necrosis, Acute / Q000139:chemically induced; D000432:Methanol; D009336:Necrosis / Q000139:chemically induced; D010936:Plant Extracts / Q000032:analysis / Q000633:toxicity*; D010946:Plants, Medicinal / Q000032:analysis; D051381:Rats; D013019:South Africa
D010936:Plant Extracts; D001278:Atractyloside; D000432:Methanol