Ticarcillin: pharmacokinetics in man according to different administration schedules.
The pharmacokinetic characteristics of ticarcillin, a semisynthetic penicillin more active than carbenicillin against Pseudomonas, were studied. Following a rapid intravenous infusion of 1 g, 2 g, 5 g and 10 g ticarcillin respectively the serum half-life was 72-4 minutes independent of the dosage administered. If ticarcillin is administered under steady-state conditions, e.g. continuous infusion of either 2g/hr or 1g/hr following a loading dose of 1g (total dose 5 g) the average steady-state serum concentrations are 125 microgram/ml and 105 microgram/ml respectively.
D005260:Female; D006207:Half-Life; D006801:Humans; D007275:Injections, Intravenous; D008297:Male; D010406:Penicillins / Q000008:administration & dosage*; D013982:Ticarcillin / Q000008:administration & dosage* / Q000097:blood / Q000378:metabolism; D013997:Time Factors
D010406:Penicillins; D013982:Ticarcillin