Use of esterified retinol to trace the degradation of chylomicrons in cholesterol-fed rabbits.
Moderately hypercholesterolemic rabbits hydrolyzed chylomicron TG at the same rate as normal animals, but were found to accumulate partially degraded intestinal lipoproteins of Sf 100-400 and Sf 20-100. These results support the hypothesis that the hypercholesterolemia induced by cholesterol feeding results at least in part from an inability to clear chylomicron remnants in proportion to the rate of their formation.
D000818:Animals; D002788:Cholesterol Esters / Q000097:blood*; D002791:Cholesterol, Dietary / Q000378:metabolism*; D002914:Chylomicrons / Q000097:blood*; D008074:Lipoproteins / Q000097:blood*; D008099:Liver / Q000378:metabolism*; D008657:Metabolic Clearance Rate; D011817:Rabbits; D014801:Vitamin A / Q000031:analogs & derivatives* / Q000097:blood
D002788:Cholesterol Esters; D002791:Cholesterol, Dietary; D002914:Chylomicrons; D008074:Lipoproteins; D014801:Vitamin A