Interactions between alcohol and other drugs on open-field and temperature measurements in gerbils.
Open-field activity and rectal temperature were measured in mongolian gerbils treated with alcholol (1 and 2 g/kg) only and when alcohol was combined with bemegride (20 and 40 mg/kg), DH-524 (20 mg/kg), or d-amphetamine (8 mg/kg). None of the purported antagonists normalized the alcholol-produced changes in the open-field test, nor did they reverse the alcohol-induced hypothermia. However, alcohol offered protection against bemegride-induced convulsion and death. When compared with pervious data (1) it is suggested that alcohol is differentiated from pentobarbital and diazepam on the basis of their interactional effects with bemegride.
D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects*; D001534:Bemegride / Q000494:pharmacology; D001831:Body Temperature / Q000187:drug effects*; D003913:Dextroamphetamine / Q000494:pharmacology; D004347:Drug Interactions; D000431:Ethanol / Q000494:pharmacology*; D005260:Female; D005849:Gerbillinae; D007093:Imidazoles / Q000494:pharmacology; D009043:Motor Activity / Q000187:drug effects; D010647:Phenyl Ethers / Q000494:pharmacology
D007093:Imidazoles; D010647:Phenyl Ethers; D000431:Ethanol; D001534:Bemegride; D003913:Dextroamphetamine