Synthesis of 2,3-dinor-PGFalpha metabolites.
This report describes the preparation of various 2,3-dinor-PGFalpha prostaglandins. Of particular importance is the synthesis of 2,3-dinor-15(S)-15-methyl PGF2alpha, the primary metabolite in the enzymatic degradation of 15(S)-15-methyl-PGF2alpha (1). Introduction of the three carbon beta,gamma-unsaturated carboxyl side chain was achieved in a one-step Wittig reaction. The 2,3-dinor structural assignments were established by carbon magnetic resonance (cmr) spectroscopy.
D055598:Chemical Phenomena; D002621:Chemistry; D008722:Methods; D011460:Prostaglandins F / Q000378:metabolism; D011461:Prostaglandins F, Synthetic / Q000138:chemical synthesis*
D011460:Prostaglandins F; D011461:Prostaglandins F, Synthetic