Clinical pharmacology of hexachlorophene in newborn infants.
Bathing with soap containing hexachlorophene was instituted during two major staphylococcal epidemics in a Neonatal Intensive Care Unit. Infants who weighed less than 1,200 gm, those with a postconceptional age of less than 35 weeks, and those with large areas of abraded skin were at highest risk to achieve elevated blood HCP concentrations. T 1/2 of HCP ranged from 6.1 to 44.2 hours and appeared to follow first order kinetics. Time of peak blood concentrations of HCP following a bath ranged from 6 to 10 hours. One infant with liver disease achieved a concentration of HCP of 4,350 ng/ml after seven baths and developed clinical symptoms consistent with HCP toxicity.
D001344:Autopsy; D001494:Baths; D001724:Birth Weight; D004196:Disease Outbreaks / Q000517:prevention & control; D005260:Female; D005865:Gestational Age; D006207:Half-Life; D006582:Hexachlorophene / Q000009:adverse effects / Q000378:metabolism*; D006801:Humans; D007231:Infant, Newborn; D007232:Infant, Newborn, Diseases / Q000517:prevention & control; D007362:Intensive Care Units; D007700:Kinetics; D008107:Liver Diseases / Q000209:etiology; D009725:Nurseries, Hospital; D013203:Staphylococcal Infections / Q000517:prevention & control
D006582:Hexachlorophene