[DNA synthesis by granulation tissue fibroblasts under conditions of stimulation of the wound process].
The changes in the DNA synthesis in the granulation  tissue fibroblasts in the wounds of adult animals given potassium orotate and in controls were studied. For this purpose a daily autoradiographic examination of the wound areas were conducted in the both groups of animals. It appeared that under the effect of potassium orotate (0.2 ml of 2% solution) there was more frequent involvement of fibroblasts  into  the DNA synthesis; under conditions of the wound process stimulation there occurred an increase of the proliferative activity of these cells.
D000818:Animals; D004247:DNA / Q000096:biosynthesis*; D005347:Fibroblasts / Q000378:metabolism*; D006097:Granulation Tissue / Q000166:cytology / Q000378:metabolism*; D051379:Mice; D009963:Orotic Acid / Q000494:pharmacology*; D011188:Potassium / Q000494:pharmacology; D012867:Skin / Q000293:injuries / Q000378:metabolism; D013268:Stimulation, Chemical; D013997:Time Factors; D014945:Wound Healing / Q000187:drug effects*
D009963:Orotic Acid; D004247:DNA; D011188:Potassium
Osobennosti sinteza DNK fibroblastami granuliatsionnoĭ tkani v usloviiakh stimuliatsii ranevogo protsessa.