[Cholesterol-7-alpha-hydroxylase activity in cholelithiasis].
The physiopathological mechanism of cholesterol supersaturation in the bile was investigated by determining cholesterol-7-alpha-hydroxylase activity in 5 normal controls and 8 subjects with cholesterol gallstones. Bile lipids were also evaluated. Hydroxylase values were higher (though not significantly) in the controls. A linear correlation (r = 0.797) between the hydroxylase and bile acid concentration was noted in both groups.
D000328:Adult; D001646:Bile / Q000378:metabolism*; D001647:Bile Acids and Salts / Q000378:metabolism; D002769:Cholelithiasis / Q000201:enzymology*; D002790:Cholesterol 7-alpha-Hydroxylase / Q000378:metabolism*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D013250:Steroid Hydroxylases / Q000378:metabolism*
D001647:Bile Acids and Salts; D013250:Steroid Hydroxylases; D002790:Cholesterol 7-alpha-Hydroxylase
L'attività colesterols-7-alfa-idrossilasi nella colelitiasi.