title: Some possibilities for prostaglandin mediation in the contractile response to ATP of the guinea-pig digestive tract.
abstract: Several contractile responses of longitudinal muscles of the guinea-pig digestive tract to exogenously applied ATP (10-300 micrometer), including "rebound" contractions, were inhibited by indomethacin (3-20 micrometer) or polyphloretin phosphate (10-100 microgram/ml). Relaxations to ATP  in stomach and large intestinal muscles were increased by these drugs. Prostaglandin release might therefore contribute to the contractile responses of the guinea-pig digestive tract to ATP.
mesh_terms: D000255:Adenosine Triphosphate / Q000494:pharmacology*; D000818:Animals; D004064:Digestive System / Q000187:drug effects; D004347:Drug Interactions; D006168:Guinea Pigs; D066298:In Vitro Techniques; D007213:Indomethacin / Q000494:pharmacology; D008297:Male; D009119:Muscle Contraction / Q000187:drug effects*; D009130:Muscle, Smooth / Q000187:drug effects*; D011121:Polyphloretin Phosphate / Q000494:pharmacology; D011453:Prostaglandins / Q000502:physiology*
chemical_list: D011453:Prostaglandins; D000255:Adenosine Triphosphate; D011121:Polyphloretin Phosphate; D007213:Indomethacin