Increase of phagocytic activity and new appearance of a C4b (guinea pig) recognizing capability in peritoneal macrophages from Corynebacterium parvum and thioglycollate-stimulated mice.
Activated mouse macrophages displayed enhanced phagocytic activity towards particles opsonized with IgG antibody and homologous C3. In addition, they were able to recognize guinea pig C4b. It is concluded that activated macrophages develop phagocytically active receptors for heterologous C4b.
D000818:Animals; D001665:Binding Sites; D003176:Complement C3 / Q000378:metabolism; D003181:Complement C4 / Q000378:metabolism*; D004912:Erythrocytes / Q000276:immunology; D006168:Guinea Pigs; D007140:Immunoglobulin Fab Fragments; D007074:Immunoglobulin G; D008264:Macrophages / Q000276:immunology*; D051379:Mice; D010587:Phagocytosis; D011425:Propionibacterium acnes; D012756:Sheep; D013864:Thioglycolates / Q000494:pharmacology*; D015054:Zymosan / Q000494:pharmacology
D003176:Complement C3; D003181:Complement C4; D007140:Immunoglobulin Fab Fragments; D007074:Immunoglobulin G; D013864:Thioglycolates; D015054:Zymosan