title: The gastrointestinal myoelectric response to 13-Nle-motilin infusion during interdigestive and digestive states in the conscious dog.
abstract: Gastrointestinal myoelectric activity was studied in three conscious fasted dogs with electrodes surgically implanted in the stomach and small intestine, during separate and combined intravenous infusions of 13-norleucine motilin (13-nle-motilin) and pentagastrin (PG). Basal recordings confirmed the presence of regular interdigestive myoelectric complexes (MC's). 13-nle-motilin infusion below 50 ng/kg-h was without effect: higher doses up to 400 ng/kg-h resulted in the interpolation of one or more MC's in the spontaneous sequence. The rate of aboral transit of 13-nle-molitin-induced MC's did not differ significantly from that of spontaneous MC's. When MC's were abolished by feeding or PG infusion, simultaneous 13-nle-motilin administration was without effect on spike activity, but slightly attenuated the accelerating effect of gastrin on the gastric pacemaker frequency. The myoelectric events triggered by 13-nle-motilin suggest that in the conscious dog the polypeptide may not act directly on the smooth muscle cell, as it does in vitro, but through an extra-enteric neural control mechanism which is uncoupled by gastrin.
mesh_terms: D000614:Aminocaproates / Q000494:pharmacology*; D000818:Animals; D003243:Consciousness; D004063:Digestion; D004285:Dogs; D004576:Electromyography; D004594:Electrophysiology; D005260:Female; D005768:Gastrointestinal Hormones / Q000494:pharmacology*; D005769:Gastrointestinal Motility / Q000187:drug effects*; D008297:Male; D009037:Motilin / Q000494:pharmacology*; D009646:Norleucine / Q000494:pharmacology*; D010418:Pentagastrin / Q000494:pharmacology; D013268:Stimulation, Chemical
chemical_list: D000614:Aminocaproates; D005768:Gastrointestinal Hormones; D009037:Motilin; D009646:Norleucine; D010418:Pentagastrin