title: Effects of iron deficiency on the absorption and distribution of lead and cadmium in rats.
abstract: In order to evaluate the effects of iron deficiency on the absorption of pollutant metals, an iron-deficient diet was fed to young rats until their tissue-iron stores were depleted. Prior to the development of anemia, the iron-deficient rats and littermate controls were administered an intragastric gavage of lead-210 or cadmium-109 and were killed 48 hr later. The body burden of lead was approximately 6 times greater, and that of cadmium approximately 7 times greater, in iron-deficient rats than in the controls. No consistent effects were observed on concentrations of serum total lipids or serum proteins nor on protein electrophoretic patterns in rats with a deficit in iron stores.
mesh_terms: D000747:Anemia, Hypochromic / Q000378:metabolism*; D000818:Animals; D001798:Blood Proteins / Q000378:metabolism; D001822:Body Burden; D002104:Cadmium / Q000378:metabolism*; D005260:Female; D006400:Hematocrit; D007408:Intestinal Absorption; D007854:Lead / Q000378:metabolism*; D008055:Lipids / Q000097:blood; D051381:Rats; D014018:Tissue Distribution
chemical_list: D001798:Blood Proteins; D008055:Lipids; D002104:Cadmium; D007854:Lead