title: [Change in the normal microflora of the intestinal tract of rats in the process of their decontamination].
abstract: The authors studied a possibility of decontamination of animals by using antibiotics and a sterile diet, and also a combination of both methods. A reduction of the species composition of the intestinal microbial flora was noted in rats on sterile diet kept under conditions limiting the penetration of microbes into the organism from the external environment. Its greatest rarefaction -- practically to individual species -- was observed when the antibiotics were used in combination with a partial gnotobiotic isolation. In studying the action of antibiotics on the bacterial flora it is recommended to use the gnotobiotic isolation chamber to prevent the entrance of vulgar microbial flora from the surrounding environment.
mesh_terms: D000821:Animal Feed; D000818:Animals; D000900:Anti-Bacterial Agents / Q000494:pharmacology; D003666:Decontamination / Q000379:methods*; D004032:Diet; D004305:Dose-Response Relationship, Drug; D004755:Enterobacteriaceae / Q000187:drug effects; D005243:Feces / Q000382:microbiology; D005856:Germ-Free Life / Q000187:drug effects; D006799:Housing, Animal; D007422:Intestines / Q000382:microbiology*; D009929:Organ Size; D051381:Rats; D013997:Time Factors
chemical_list: D000900:Anti-Bacterial Agents
vernacular_title: Izmenenie normal'noĭ mikroflory kishechnogo trakta krys v protsesse ikh dekontaminatsii.