title: Microsomal hexobarbital metabolizing enzymes in regenerating cholestatic rat liver.
abstract: Microsomal changes were studied in regenerating liver cholestatic rats by measuring hexobarbital metabolzing capacity (HMC) in vitro. Total extrahepatic biliary obstruction was induced by ligating the common duct, 3 days later, a 70% liver resection was performed. Sham-operated animals served as controls. Analysis of HMC showed a similar pattern of microsomal regeneration in cholestatic as in sham-operated rats. This indicates that in the rat, cholestasis per se does not interfere with the development of this enzyme system during regeneration.
mesh_terms: D000469:Alkaline Phosphatase / Q000097:blood; D000818:Animals; D001663:Bilirubin / Q000097:blood; D002779:Cholestasis / Q000201:enzymology*; D006591:Hexobarbital / Q000378:metabolism*; D008115:Liver Regeneration; D008297:Male; D008862:Microsomes, Liver / Q000201:enzymology* / Q000378:metabolism; D051381:Rats
chemical_list: D006591:Hexobarbital; D000469:Alkaline Phosphatase; D001663:Bilirubin