title: Soluble factors in tolerance and contact sensitivity to DNFB in mice. II. Genetic requirements for suppression of contact sensitivity by soluble suppressor factor.
abstract: Active suppression of contact sensitivity to DNFB in mice is mediated by a soluble suppressor factor (SSF) which is released in vitro by cultures of LN cells that contain antigen-specific suppressor T cells. For SSF-mediated suppression to occur, identity is required among genes in the H-2 complex between the donor of SSF and the donar of DNFB-immune LN cells. Identity in either the left half or right half of the H-2 complex was found to be both sufficient and required. Additional experiments using congeneic strains with intra-H-2 recombinants showed that the genetic homology which was required mapped to genes contained in the H-2K and/or H-2D regions of the H-2 complex.
mesh_terms: D000818:Animals; D000941:Antigens; D002874:Chromosome Mapping; D003877:Dermatitis, Contact / Q000276:immunology*; D004136:Dinitrobenzenes / Q000276:immunology; D005796:Genes; D008040:Genetic Linkage; D006183:H-2 Antigens; D007108:Immune Tolerance; D051379:Mice; D008805:Mice, Inbred A; D008809:Mice, Inbred C3H; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D011995:Recombination, Genetic; D013045:Species Specificity
chemical_list: D000941:Antigens; D004136:Dinitrobenzenes; D006183:H-2 Antigens