A method for detecting 8-methoxypsoralen in the ocular lens.
The use of 8-methoxypsoralen for treating psoriasis could prove hazardous if this photosensitizing agent enters the ocular lens. Phosphorescence spectra of intact rat lenses reveal concentrations of 8-methoxypsoralen on the order 10(-5)M after intraperitoneal injection of 8-methoxypsoralen. There is evidence that this drug can function as a photosensitizing agent, enhancing ultraviolet-induced changes within the lens.
D000818:Animals; D003374:Coumarins / Q000032:analysis*; D005363:Ficusin / Q000032:analysis* / Q000378:metabolism; D011564:Furocoumarins; D007908:Lens, Crystalline / Q000032:analysis* / Q000378:metabolism; D049449:Luminescence; D010777:Photochemistry; D051381:Rats; D013050:Spectrometry, Fluorescence; D014466:Ultraviolet Rays
D003374:Coumarins; D011564:Furocoumarins; D005363:Ficusin