Clofibrate-induced myopathy in the rat.
Rats were given daily injections of 0.2 or 0.5 g/kg chlorophenoxyisobutyrate (clofibrate) for 9 to 46 days. Lower leg muscles were studied with light and electron microscopy. Daily treatment with 0.5 g/kg of the drug for 26--46 days caused myopathic changes.
D000818:Animals; D002994:Clofibrate; D005260:Female; D008854:Microscopy, Electron; D009132:Muscles / Q000473:pathology; D009135:Muscular Diseases / Q000139:chemically induced / Q000473:pathology; D051381:Rats; D013997:Time Factors
D002994:Clofibrate