Linear and nonlinear assessment of tolmetin pharmacokinetics.
Plasma concentration-time data in man after oral dosing of the nonsteroidal antiinflammatory agent, tolmetin sodium, were fitted to both linear and nonlinear pharmacokinetic equations. The apparent elimination half-life of tolmetin is shown to be 4.5 to 6.0 hours. An analytical method is presented which allows measurement of plasma concentrations for at least 32 hr (compared with a previous limit of about 8 hr) after a single oral dose of the equivalent of 400 mg of tolmetin acid.
D000328:Adult; D001682:Biological Availability; D006207:Half-Life; D006801:Humans; D007668:Kidney / Q000378:metabolism; D007700:Kinetics; D008297:Male; D008722:Methods; D008954:Models, Biological; D011758:Pyrroles / Q000378:metabolism*; D013997:Time Factors; D014046:Tolmetin / Q000097:blood / Q000378:metabolism* / Q000652:urine
D011758:Pyrroles; D014046:Tolmetin