Anatomo-clinical correlations in normotensive hydrocephalus. Reports on three cases.
The brains of 3 adult subjects suffering from normotensive hydrocephalus have been examined pathologically. The diagnosis of normotensive hydrocephalus was based on clinical symptoms, pneumoencephalography and isotope cisternography, in 1 case integrated with the results of the constant-infusion manometric test. Part of the neuropathological findings were common to the 3 patients: leptomeningeal non-obstructive fibrosis, ventricular ependymal disruption, subependymal glial reaction, periventricular demyelination and spongiosis. Other neuropathological abnormalities were peculiar to each patient: leptomeningeal signs of previous subarachnoid haemorrhage; arteriosclerosis and multiple brain cystic infarcts; Alzheimer's plaques in the gray matter. The possible pathogenetic significance of the neuropathological findings summarized above in relation to the development of normotensive hydrocephalus is discussed.
D000328:Adult; D000544:Alzheimer Disease / Q000150:complications; D001921:Brain / Q000473:pathology*; D002561:Cerebrovascular Disorders / Q000150:complications; D006801:Humans; D006849:Hydrocephalus / Q000473:pathology*; D006850:Hydrocephalus, Normal Pressure / Q000209:etiology / Q000473:pathology*; D002537:Intracranial Arteriosclerosis / Q000150:complications; D008297:Male; D008875:Middle Aged; D010841:Pia Mater / Q000473:pathology