Effect of parathyroid hormone and volume expansion on jejunal calcium, sodium, and water transport in the rat.
The effects of PTH on jejunal calcium, sodium, and water transport were studied in the rat in situ. In TPTx rats, as well as in normal rats, bovine PTH induced a decrease in net calcium, sodium, and water absorption. Additionally, lumen-to-plasma calcium flux was found decreased in both groups. Stimulation of endogenous PTH secretion by calcium-poor hyperoncotic albumin resulted in a similar decrease in net calcium, sodium, and water absorption. It is suggested that PTH has a direct inhibitory effect on jejunal calcium, sodium, and water absorption.
D000418:Albumins / Q000494:pharmacology; D000818:Animals; D001810:Blood Volume; D002118:Calcium / Q000097:blood / Q000378:metabolism*; D003864:Depression, Chemical; D007408:Intestinal Absorption / Q000187:drug effects; D007583:Jejunum / Q000378:metabolism*; D008297:Male; D010281:Parathyroid Hormone / Q000378:metabolism / Q000494:pharmacology*; D051381:Rats; D012964:Sodium / Q000378:metabolism*; D013965:Thyroidectomy; D014867:Water / Q000378:metabolism*; D014882:Water-Electrolyte Balance
D000418:Albumins; D010281:Parathyroid Hormone; D014867:Water; D012964:Sodium; D002118:Calcium