title: Absence of autoregulation in peripheral nerve blood flow.
abstract: Blood flow was measured in the sciatic nerve of cats utilizing the method of hydrogen polarography. The mean baseline blood flow for all animals was found to be 47.1 ml/100 g/min +/- 14.9 SD. The flow changes produced by lowering the blood pressure by exsanguination and elevation by the use of angiotensin were then evaluated. The highest (normal) levels of blood flow were observed between the mean blood pressures of 80-110 mm Hg. At mean systemic arterial pressures of less than 85, there was a marked decrease in peripheral nerve blood flow with no detectable flow being measured below mean systemic pressures of 50 mm Hg. Above 105 mm Hg mean arterial pressure, there was a very gradual and progressive decline in blood flow to the levels measured at 200 mm Hg. These findings indicate a complete absence of vascular autoregulation in the peripheral nerve trunks.
mesh_terms: D000818:Animals; D001794:Blood Pressure; D001808:Blood Vessels / Q000502:physiology*; D002415:Cats; D006706:Homeostasis; D010525:Peripheral Nerves / Q000098:blood supply*; D012039:Regional Blood Flow; D014650:Vasa Nervorum / Q000502:physiology*