Mechanisms of resistance to Corynebacterium kutscheri in mice.
Involvement of the mononuclear phagocyte system in the mechanism of resistance to Corynebacterium kutscheri was studied in C57B1/6 and Swiss Lynch mice. A major difference between the two mouse strains was that the phagocytic cells of the livers of C57B1/6 mice destroyed the bacteria with much greater efficiency. There was no evidence of serum factors which might have led to this greater bacterial killing observed in the C57B1/6 mice, and in vivo phagocytosis of C. kutscheri was identical in both mouse strains. Resistance to C. kutscheri could be transferred with spleen and/or bone marrow cells from resistant (Swiss Lynch X C57B1/6) F1 mice to 650-rad irradiated susceptible Swiss Lynch mice. Nonspecific and acquired mechanisms of resistance to C. kutscheri are discussed.
D000818:Animals; D001769:Blood / Q000382:microbiology; D001770:Blood Bactericidal Activity; D001853:Bone Marrow / Q000276:immunology; D001854:Bone Marrow Cells; D003352:Corynebacterium / Q000276:immunology / Q000302:isolation & purification; D003354:Corynebacterium Infections / Q000276:immunology*; D007109:Immunity; D007116:Immunization, Passive; D008099:Liver / Q000276:immunology / Q000382:microbiology; D051379:Mice; D008815:Mice, Inbred Strains; D009000:Monocytes / Q000276:immunology; D010587:Phagocytosis; D013045:Species Specificity; D013154:Spleen / Q000276:immunology