Effect of methionine on the brain biogenic monoamines and on the cortical bioelectrical activity of rabbits.
Methionine (150 and 300 mg/kg ip for 3 days) did not change the concentrations of striatal DA. It was also without effect on the levels of NA and 5-HT in the diencephalon and in the brain stem, while the 5-HIAA content was significantly increased in both structures after the dose 300 mg/kg. The single injection of methionine in doses of 10--300 mg/kg iv provoked dose-dependent changes in cortical bioelectrical activity. It was observed a considerable increase in the number of spindles, an increase in the amplitude and number of waves composing the spindles as well as a rise in their frequency characteristic.
D000818:Animals; D001679:Biogenic Amines / Q000378:metabolism*; D001921:Brain / Q000187:drug effects* / Q000378:metabolism; D001933:Brain Stem / Q000378:metabolism; D002540:Cerebral Cortex / Q000187:drug effects; D003342:Corpus Striatum / Q000378:metabolism; D004027:Diencephalon / Q000378:metabolism; D004298:Dopamine / Q000378:metabolism; D005260:Female; D006897:Hydroxyindoleacetic Acid / Q000378:metabolism; D008297:Male; D008715:Methionine / Q000494:pharmacology*; D009638:Norepinephrine / Q000378:metabolism; D011817:Rabbits; D012701:Serotonin / Q000378:metabolism
D001679:Biogenic Amines; D012701:Serotonin; D006897:Hydroxyindoleacetic Acid; D008715:Methionine; D004298:Dopamine; D009638:Norepinephrine