Antifilarial agents. 3-Aminopyrrolidine and 1,4-diazabicyclo[3.2.1]octane derivatives as analogues of diethylcarbamazine.
3-Aminopyrrolidines bearing acyl substituents on either nitrogen and N-acylated 1,4-diazabicyclo[3.2.1]octanes are potent microfilaricides in the Litomosoides carinii gerbil test system but have no effect on adult worms. The high activity of the pyrrolidine derivatives establishes that diethylcarbamazine (DEC) like antifilarial activity does not require that both pharmacophores be incorporated into one ring. Results with the 1,4-diazabicyclo[3.2.1]octanes establish that an axial conformation of the alkyl substituent corresponding to the equatorial N-methyl group of diethylcarbamazine is fully consistent with high activity. Other conformational consideration pertinent to DEC analogues are discussed.
D000818:Animals; D000871:Anthelmintics / Q000138:chemical synthesis*; D001643:Bridged Bicyclo Compounds / Q000138:chemical synthesis / Q000494:pharmacology; D004049:Diethylcarbamazine / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000494:pharmacology; D005368:Filariasis / Q000188:drug therapy; D005369:Filaricides / Q000138:chemical synthesis*; D005849:Gerbillinae; D008968:Molecular Conformation; D011759:Pyrrolidines / Q000138:chemical synthesis / Q000494:pharmacology; D013329:Structure-Activity Relationship
D000871:Anthelmintics; D001643:Bridged Bicyclo Compounds; D005369:Filaricides; D011759:Pyrrolidines; D004049:Diethylcarbamazine