Haemodynamic side effects of antilymphocyte serum.
Haemodynamic side effects of antilymphocyte serum (ALS) have been studied in six dogs treated with equine anti-dog ALS. All animals responded with a severe but transient reduction of cardiac output and, in most cases, a drop in aortic pressure. This effect is best explained by a direct negative inotropic action followed by secondary vasoconstriction. An indirect effect of ALS by release of cardiotoxic substances from damaged blood cells seems to be a more probable explanation than a direct action of ALS on cardiac cell membranes.
D000818:Animals; D000961:Antilymphocyte Serum / Q000009:adverse effects*; D001011:Aorta; D001794:Blood Pressure / Q000187:drug effects*; D002302:Cardiac Output / Q000187:drug effects*; D004285:Dogs; D009200:Myocardial Contraction / Q000187:drug effects; D011651:Pulmonary Artery; D013997:Time Factors; D014655:Vascular Resistance / Q000187:drug effects
D000961:Antilymphocyte Serum