title: Atopic disease in seven-year-old children. Incidence in relation to family history.
abstract: The incidence of atopic disease and its relation to the family history was studied by questionnaire in 1325 children, 7 years of age. A higher incidence of bronchial asthma (2.7%) was found than in a previous Swedish study. The total incidence of atopic disease in the children was 15.1% with a higher level when there was a double parental history of such disease (42.6%) as compared with a single such history (19.8%). When both parents had an identical type of atopic disease, i.e. respiratory or skin, the incidence of atopic disease was higher (72.2%) than when non-identical types occurred in the parents (20.8%). The findings support theories of a polygenic transmission of atopic disease as well as a genetic influence on symptom specificity in such disease and may be of value in genetic counselling.
mesh_terms: D000367:Age Factors; D001249:Asthma / Q000453:epidemiology / Q000235:genetics; D002648:Child; D003876:Dermatitis, Atopic / Q000453:epidemiology / Q000235:genetics; D005260:Female; D006801:Humans; D006969:Hypersensitivity, Immediate / Q000453:epidemiology* / Q000235:genetics; D008297:Male; D010033:Otitis Media / Q000453:epidemiology / Q000235:genetics; D006255:Rhinitis, Allergic, Seasonal / Q000453:epidemiology / Q000235:genetics; D013548:Sweden; D014581:Urticaria / Q000453:epidemiology / Q000235:genetics