[Vasoactive intestinal polypeptide (VIP) tissue distribution in the rat as measured by radioimmunoassay and by radioreceptorassay (author's transl)].
A new radioimmunoassay which allows the measurement of the rat vasoactive intestinal polypeptide, was performed. VIP is present in the whole digestive tract of rat, mainly between the duodenum and the colon. 1.5% of the total VIP is present in brain. The VIP-like immunoreactivity appears to correspond to biologically active molecule since a radioreceptorassay using liver plasma membranes as the target tissue, gives the same results as the radioimmunoassay.
D000818:Animals; D001681:Biological Assay; D001923:Brain Chemistry; D002462:Cell Membrane / Q000378:metabolism; D004064:Digestive System / Q000032:analysis*; D005768:Gastrointestinal Hormones / Q000032:analysis*; D008099:Liver / Q000378:metabolism; D009928:Organ Specificity; D011863:Radioimmunoassay; D011869:Radioligand Assay; D051381:Rats; D011955:Receptors, Drug / Q000378:metabolism; D014660:Vasoactive Intestinal Peptide / Q000032:analysis* / Q000378:metabolism
D005768:Gastrointestinal Hormones; D011955:Receptors, Drug; D014660:Vasoactive Intestinal Peptide
Distribution du peptide intestinal vasoactif (VIP), chez le rat. Dosage par radioimmunologie et par radiorécepteurs.