Effect of levamisole on malignant experimental neurinoma grown subcutaneously in a young rat: brief communication.
Levamisole, a drug that stimulates the immunologic defenses of the host, was tested on the experimental malignant neurinoma grown subcutaneously in young female inbred CDF rats in 3-month trial. The drug resulted in prevention of tumor growth in 80% of the treated animals, whereas tumors grew in 100% of the controls. After discontinuation of the drug, none of the animals in the treated group showed evidence of tumor growth upon clinical and pathologic examination 1 month after drug treatment was terminated. Treated animals failed to show any side effects related to levamisole upon clinical and pathologic examination.
D000818:Animals; D004353:Drug Evaluation, Preclinical; D007167:Immunotherapy / Q000379:methods*; D066298:In Vitro Techniques; D007978:Levamisole / Q000627:therapeutic use*; D009368:Neoplasm Transplantation; D009374:Neoplasms, Experimental / Q000276:immunology / Q000473:pathology / Q000517:prevention & control; D009442:Neurilemmoma / Q000276:immunology / Q000473:pathology / Q000517:prevention & control*; D051381:Rats; D011919:Rats, Inbred Strains
D007978:Levamisole