title: Intraoperative and postoperative esophageal manometric findings with Collis gastroplasty and Belsey hiatal hernia repair for gastroesophageal reflux.
abstract: The combination of a Collis gastroplasty with a Belsey Mark IV fundoplication has proved clinically effective in the management of certain patients with complications of gastroesophageal reflux. The present study measured the effect of gastroplasty and Belsey repair on intraluminal pressure changes in the gastroplasty and lower esophagus. Manometric studies were performed preoperatively, intraoperatively, and postoperatively. In each case the gastroplasty segment of the esophagus was found to function as a high pressure zone (HPZ). The pressure in this zone further increased following the fundoplication. It could be diminished with intravenous administration of Buscopan and augmented with intravenously given pentagastrin. The original lower esophageal sphincter in most instances was included in the upper segment of the gastroplasty tube, but the entire length of the gastroplasty tube functioned as an HPZ, and pressures in the tube were considerably higher than those originally present in the lower esophageal sphincter. These studies provide a physiological rationale for the effectiveness of gastroplasty and fundoplication.
mesh_terms: D000818:Animals; D002086:Butylscopolammonium Bromide / Q000494:pharmacology; D004943:Esophagogastric Junction / Q000601:surgery; D004947:Esophagus / Q000187:drug effects / Q000601:surgery; D005764:Gastroesophageal Reflux / Q000601:surgery*; D006548:Hernia, Diaphragmatic / Q000601:surgery*; D006551:Hernia, Hiatal / Q000601:surgery*; D006801:Humans; D008365:Manometry; D010418:Pentagastrin / Q000494:pharmacology; D011312:Pressure; D013270:Stomach / Q000601:surgery*; D014159:Transducers
chemical_list: D002086:Butylscopolammonium Bromide; D010418:Pentagastrin