Three-year prospective study of carbohydrate metabolism in women using Ovulen.
Twenty-eight women were tested with a standard three-hour oral glucose tolerance test before and after three years of using a combination-type oral contraceptive containing mestranol and ethynodiol diacetate (Ovulen). At the three-year test time there was a significant elevation of the patients' weights and their 1-, 2-, and 3-hour blood glucose and 2- and 3-hour plasma insulin values. Pretreatment control tests had shown no "abnormal" blood glucose curves, whereas at the three-year test 17.2% of the curves were "abnormal". Serial follow-up studies in two women after stopping the medication showed that the abnormal glucose curves reverted to their pretreatment status within 12 months.
D000293:Adolescent; D000328:Adult; D001786:Blood Glucose / Q000378:metabolism*; D003277:Contraceptives, Oral, Combined / Q000009:adverse effects; D005040:Ethynodiol Diacetate / Q000009:adverse effects; D005260:Female; D005431:Florida; D005951:Glucose Tolerance Test; D006801:Humans; D008656:Mestranol / Q000009:adverse effects; D008875:Middle Aged; D011446:Prospective Studies
D001786:Blood Glucose; D003277:Contraceptives, Oral, Combined; D005040:Ethynodiol Diacetate; D008656:Mestranol