Studies on drug metabolism and liver ultrastructure after conjoint treatment with pregnenolone-16alpha-carbonitrile and dl-ethionine.
Zoxazolamine paralysis, hexobarbital anesthesia and digitoxin convulsions were diminished in rats by 3 days of pretreatment with pregnenolone-16alpha-carbonitrile (PCN). Simultaneous injection of dl-ethionine did not block this effect of PCN. Dl-Ethionine decreased, while PCN or PCN + ethionene increased, zoxazolamine metabolism by the 9,000g supernatant fraction of the liver. Dl-ethionine neutralized the influence of PCN and phenobarbital on zoxazolamine metabolism in rats that were pretreated with PCN or phenobarbital for 1 day, and it inhibited the action of phenobarbital on hexobarbital anesthesia. PCN augmented the liver weight of animals given dl-ehtionine whereas dl-ethionine in itself did not. PCN produced SER proliferation in hepatocytes and dl-ethionine caused lipid accumulation, SER proliferation and myelin-figure formation. When administered conjointly, these compounds had an additive effect on the liver cell ultrastructure.
D000818:Animals; D004074:Digitoxin / Q000494:pharmacology; D004347:Drug Interactions; D005001:Ethionine / Q000494:pharmacology*; D005260:Female; D006591:Hexobarbital / Q000494:pharmacology; D066298:In Vitro Techniques; D008099:Liver / Q000187:drug effects / Q000648:ultrastructure*; D008854:Microscopy, Electron; D010243:Paralysis / Q000139:chemically induced / Q000503:physiopathology; D004364:Pharmaceutical Preparations / Q000378:metabolism*; D010634:Phenobarbital / Q000494:pharmacology; D011285:Pregnenolone Carbonitrile / Q000494:pharmacology*; D051381:Rats; D012640:Seizures / Q000139:chemically induced / Q000503:physiopathology; D012890:Sleep / Q000187:drug effects; D015049:Zoxazolamine / Q000378:metabolism / Q000494:pharmacology
D004364:Pharmaceutical Preparations; D011285:Pregnenolone Carbonitrile; D015049:Zoxazolamine; D006591:Hexobarbital; D004074:Digitoxin; D005001:Ethionine; D010634:Phenobarbital