[Erythropoiesis in the mouse following chronic administration of small doses of busulphan (author's transl)].
After both splenectomized and non-splenectomized mice had received a total amount of five doses of Busulfan at a rate of 0.14 mg/48 h, the recovery of their erythropoietic organs through the addition of 59Fe was investigated, after the cytostatic treatment had been cut off. In the non-splenectomized animals recovery was clear, keeping high 59Fe uptake values, significantly above normal, throughout the 21 days of the experiment. In the splenectomized mice, 59Fe uptake reached a peak of 38 per cent three days after the supply had been cut off, and from then on it descended to subnormal values.
D000818:Animals; D002066:Busulfan / Q000008:administration & dosage / Q000494:pharmacology*; D004920:Erythropoiesis / Q000187:drug effects*; D005260:Female; D007501:Iron / Q000378:metabolism*; D051379:Mice; D013154:Spleen / Q000502:physiology*; D013156:Splenectomy; D013268:Stimulation, Chemical
D007501:Iron; D002066:Busulfan
Hematopoiesis en el ratón después de la administración de busulfán.