title: The stress-related emotional lability syndrome. II. A multicentre evaluation of Orap.
abstract: This four-week study included 336 patients aged eleven to 80 years with complaints suggestive of stress-related emotional lability, and was intened to discover a possible relationship between the effects of pimozide and the initial psychic defence phenomena in this condition: the discouragement type of reaction was registered in 243 cases, overcompensation in 80, and a mixture of the two in the remaining 13. In most cases, the daily dose of pimozide remained close to the initial 2 mg, and treatment could be entirely discontinued after three-four weeks in five patients. Control evaluation after two and four weeks revealed a significant improvement of all pathological scores of a 17-item questionnaire, but failed to show any susbstantial difference between the three subgroups. No side-effects were reported.
mesh_terms: D000293:Adolescent; D000328:Adult; D000342:Affective Symptoms / Q000188:drug therapy*; D000368:Aged; D002648:Child; D004341:Drug Evaluation; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010868:Pimozide / Q000009:adverse effects / Q000627:therapeutic use*; D013315:Stress, Psychological / Q000187:drug effects*
chemical_list: D010868:Pimozide