Bile acids: co-mutagenic activity in the Salmonella-mammalian-microsome mutagenicity test: brief communication.
Of 30 bile acids tested, none was mutagenic in the Salmonella-mammalian-microsome test with indicator strains G46, TA1530, TA1535, TA1536, TA1537, TA1538, TA98, or TA100. However, when lithocholic acid or one of its conjugates was tested with suboptimal amounts of 2-aminoanthracene and phenobarbital-stimulated rat liver homogenate, enhancement and co-mutagenesis were observed if TA1538 was the indicator strain.
D000818:Animals; D000873:Anthracenes / Q000494:pharmacology; D001647:Bile Acids and Salts / Q000378:metabolism / Q000494:pharmacology*; D002273:Carcinogens / Q000494:pharmacology; D003840:Deoxycholic Acid / Q000494:pharmacology; D066298:In Vitro Techniques; D008095:Lithocholic Acid / Q000494:pharmacology; D008862:Microsomes, Liver / Q000378:metabolism*; D009153:Mutagens; D051381:Rats; D012475:Salmonella / Q000187:drug effects*; D013045:Species Specificity; D013658:Taurolithocholic Acid / Q000494:pharmacology
D000873:Anthracenes; D001647:Bile Acids and Salts; D002273:Carcinogens; D009153:Mutagens; D003840:Deoxycholic Acid; D013658:Taurolithocholic Acid; D008095:Lithocholic Acid; C006593:2-anthramine