[Behaviour of oxytetracycline and doxycycline serum levels under forced diuresis in severe bromcarbamide intoxication (author's transl)].
A dose of 500 or 1000 ml respectively was infused at hourly intervals over 12 or 24 hours respectively, using a standardised infusion schedule. It was found that this enormous increase in renal function did not cause any changes in the behaviour of the serum levels of oxytetracycline and doxycycline as compared to normal renal excretion. This result comes hardly as a surprise in the case of doxycycline due to its high degree of protein binding, it is, however, unexpected for oxytetracycline.
D000293:Adolescent; D000328:Adult; D001835:Body Weight; D004232:Diuretics / Q000627:therapeutic use*; D004318:Doxycycline / Q000097:blood*; D005919:Glomerular Filtration Rate; D006801:Humans; D006993:Hypnotics and Sedatives / Q000506:poisoning*; D010118:Oxytetracycline / Q000097:blood*; D011041:Poisoning / Q000188:drug therapy; D011485:Protein Binding
D004232:Diuretics; D006993:Hypnotics and Sedatives; D004318:Doxycycline; D010118:Oxytetracycline
Verhalten der Serumspiegel von Oxytetracyclin und Doxycyclin unter der forcierten Diurese bei schweren Schlafmittelvergiftungen.