title: [1st studies on the problem of rectal resorption of MPS in the treatment of arthroses].
abstract: Ten patients suffering from degenerative arthropathies were treated to demonstrate a significant influence of suppositoroes containing 500 mg mucopolysaccharide polysulfuric acid ester on certain clotting parameters such as plasma recalcification time, partial thromboplastin time and thrombin time. These investigations had been preceeded by blank determinations and tests with suppositories containing 250 and 400 mg resp. of active substance. It could be shown that the active substance is absorbed even if the substance is applied rectally in form of suppositories if these contain sufficient doses of MPS. Consequently, suppositories containing MPS could be used for a therapy of degenerative arthropathies whenever intraarticular and periarticular or intramuscular administration are not possible.
mesh_terms: D000368:Aged; D001777:Blood Coagulation / Q000187:drug effects; D006025:Glycosaminoglycans / Q000627:therapeutic use*; D006801:Humans; D007408:Intestinal Absorption; D007592:Joint Diseases / Q000188:drug therapy*; D012007:Rectum; D013488:Suppositories
chemical_list: D006025:Glycosaminoglycans; D013488:Suppositories
vernacular_title: Erste Untersuchungen zur Frage einer rektalen Resorption von MPS in der Arthrose-Behandlung.