title: [Physiopathological effects or erucic acid-poor rapeseed oil on rat adrenal glands].
abstract: The authors explored the influence of colza oils containing variable proportions of erucic acid ("Sinus", containing about 15 p. 100 erucic acid and K-20-40 oil, containing 0,5 p. 100) on adrenal function in the rat. The assays were performed on white male Wistar rats, aged 2.5 to 3 months. For a period of 6-10 weeks, groups of animals were maintained on diets containing 30 and 50 p. 100 of their caloric value as "Sinus" oil, and on diets containing 30 p. 100 of their caloric value as "Zero" oil (K-20-40). Control groups were placed on diets with the same percentages of normal colza or sunflower oils. Corticosterone was assayed in the adrenals and the plasma of treated and control animals. Cholesterol was assayed in the adrenals and in the serum of the same animals. It was found that the functional modifications of the adrenals in male Wistar rats are characteristic for erucic acid. The amount of functional damage to these glands is proportional to the level of erucic acid in the diet.
mesh_terms: D000311:Adrenal Glands / Q000187:drug effects / Q000502:physiology*; D000818:Animals; D001937:Brassica; D002784:Cholesterol / Q000378:metabolism; D003345:Corticosterone / Q000378:metabolism; D004041:Dietary Fats / Q000032:analysis; D004883:Erucic Acids / Q000032:analysis / Q000494:pharmacology; D005231:Fatty Acids, Unsaturated / Q000032:analysis; D006368:Helianthus; D008297:Male; D009821:Oils / Q000032:analysis / Q000494:pharmacology; D051381:Rats
chemical_list: D004041:Dietary Fats; D004883:Erucic Acids; D005231:Fatty Acids, Unsaturated; D009821:Oils; D002784:Cholesterol; D003345:Corticosterone
vernacular_title: Recherches sur les effets physiopathologiques des huiles de colza pauvres en acide érucique au niveau des surrénales chez le rat.