Benign osteoblastoma as a cause of osteomalacia. A report of two cases.
Two patients, a Japanese man and woman both aged eighteen, developed symptoms and signs of osteomalacia over a period of five years. Each of them had a benign osteoblastoma, one in the right fourth metacarpal and the other in the uppermost third of the right humerus. Resection of the tumours without any treatment by vitamin D resulted in rapid cure of the osteomalacia. Attempts to prove a phosphaturic humoral substance or vitamin D antagonist in the osteoblastoma of the humerus were unsuccessful, probably due to prompt excretion from the tumour cells.
D000293:Adolescent; D001859:Bone Neoplasms / Q000150:complications* / Q000601:surgery; D005260:Female; D006801:Humans; D006811:Humerus / Q000000981:diagnostic imaging / Q000601:surgery; D008297:Male; D008663:Metacarpus / Q000000981:diagnostic imaging / Q000601:surgery; D008856:Microscopy, Fluorescence; D010017:Osteoma, Osteoid / Q000150:complications* / Q000601:surgery; D010018:Osteomalacia / Q000000981:diagnostic imaging / Q000209:etiology*; D011859:Radiography; D014807:Vitamin D / Q000037:antagonists & inhibitors
D014807:Vitamin D