Pentose phosphate pathway and testicular steroidogenesis in rats following oxythiamine treatment.
Suppression of delta5-3beta-hydroxy steroid dehydrogenase (delta5-3beta-OHD) and glucose-6-phosphate dehydrogenase (G-6-P-D) activities along with concomitant stimulation of succinic dehydrogenase (SDH) activity were observed in the rat testicular tissues following treatment with oxythiamine HC1, an inhibitor of pentose phosphate pathway. The same treatment also resulted in an accumulation of cholesterol and ascorbic acid in the gland associated with a decrease in the weights of seminal vesicle and prostate. The results suggest a diminution in testicular steroid biogenesis following an alteration of pentose phosphate pathway.
D015096:3-Hydroxysteroid Dehydrogenases / Q000378:metabolism*; D000818:Animals; D001205:Ascorbic Acid / Q000378:metabolism; D002784:Cholesterol / Q000378:metabolism; D005954:Glucosephosphate Dehydrogenase / Q000378:metabolism*; D006651:Histocytochemistry; D007985:Leydig Cells / Q000201:enzymology; D008297:Male; D009929:Organ Size / Q000187:drug effects; D010119:Oxythiamine / Q000494:pharmacology*; D010428:Pentosephosphates / Q000378:metabolism*; D011467:Prostate / Q000033:anatomy & histology / Q000187:drug effects; D051381:Rats; D012669:Seminal Vesicles / Q000033:anatomy & histology; D013385:Succinate Dehydrogenase / Q000378:metabolism; D013737:Testis / Q000187:drug effects / Q000378:metabolism*; D013844:Thiazoles / Q000494:pharmacology*
D010428:Pentosephosphates; D013844:Thiazoles; D010119:Oxythiamine; D002784:Cholesterol; D015096:3-Hydroxysteroid Dehydrogenases; D005954:Glucosephosphate Dehydrogenase; D013385:Succinate Dehydrogenase; D001205:Ascorbic Acid