The binding of 3-14C-coumarin to serum proteins in the rat: a comparison between in vitro and in vivo estimations.
Like other benzo-pyrones, coumarin has been shown to bind to serum proteins. Under in vitro conditions irrespective of the dose which ranged from 50--3.31 microgramm/ml, the binding remained at approximately 40%. With intravenous administration an average of 4.6% of the injected dose remained in the vascular system, of this an average of 37% was bound to serum albumins. With intraperitoneal administration an average of 4% of the injected dose entered the vascular system of which an average of 36.5% was in the bound form.
D000818:Animals; D002250:Carbon Radioisotopes; D003374:Coumarins / Q000008:administration & dosage / Q000097:blood*; D005260:Female; D066298:In Vitro Techniques; D007274:Injections, Intraperitoneal; D007275:Injections, Intravenous; D011485:Protein Binding; D051381:Rats; D012709:Serum Albumin / Q000378:metabolism
D002250:Carbon Radioisotopes; D003374:Coumarins; D012709:Serum Albumin