No evidence for product inhibition of the renin-angiotensinogen reaction in the rat.
The influence of the product of the renin-angiotensinogen reaction, the des-angiotensin I-substrate (des-AI-substrate) on the renin-angiotensinogen reaction has been studied. Des-AI-substrate was prepared from purified rat angiotensinogen by reaction with immobilized renin. The des-AI-substrate had no inhibitory effect on the reaction of partially purified rat renin with rat angiotensinogen at concentrations corresponding to 0.225 or 0.45 micrometer angiotensinogen.
D000803:Angiotensin I; D000808:Angiotensinogen / Q000378:metabolism*; D000809:Angiotensins / Q000378:metabolism*; D000818:Animals; D004800:Enzymes, Immobilized; D007700:Kinetics; D008297:Male; D010446:Peptide Fragments / Q000494:pharmacology; D051381:Rats; D000092502:Renin Inhibitors
D000803:Angiotensin I; D000808:Angiotensinogen; D000809:Angiotensins; D004800:Enzymes, Immobilized; D010446:Peptide Fragments; D000092502:Renin Inhibitors