Catecholamine-sensitive adenylate cyclase of human fat cell ghosts. Inhibition of isoproterenol-stimulation by dihydroergotamine.
Isoproterenol-activation of the adenylate cyclase system of human fat cell ghosts was markedly inhibited by dihydroergotamine which had no effect on basal and NaF-stimulated enzyme activity. Our results indicate that the antilipolytic action of this substance in human adipose tissue is probably due to inhibition of catecholamine-sensitive adenylate cyclase activity.
D000262:Adenylyl Cyclases / Q000378:metabolism*; D000273:Adipose Tissue / Q000187:drug effects / Q000201:enzymology*; D001706:Biopsy; D002462:Cell Membrane / Q000187:drug effects / Q000201:enzymology; D004087:Dihydroergotamine / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D004879:Ergotamines; D006801:Humans; D007545:Isoproterenol / Q000494:pharmacology*; D012969:Sodium Fluoride / Q000494:pharmacology
D004879:Ergotamines; D004087:Dihydroergotamine; D012969:Sodium Fluoride; D000262:Adenylyl Cyclases; D007545:Isoproterenol