title: Disposition of sulfonamides in food-producing animals V: Disposition of sulfathiazole in tissue, urine, and plasma of sheep following intravenous administration.
abstract: The plasma, urine, and tissue sulfathiazole concentrations were determined at various times following intravenous administration to 12 sheep. The plasma and urine data were consistent with a one-compartment pharmacokinetic model, with an elimination half-life of 1.1 hr and a volume of distribution of 0.39 liter/kg. Sulfathiazole was eliminated by excretion of unchanged drug in urine (67%) and by formation of two metabolites. The data obtained from eight tissue sites were consistent with the one-compartment pharmacokinetic model presented and confirmed that tissue residues of sulfathiazole can be calculated from serum and urine drug concentration.
mesh_terms: D000818:Animals; D005260:Female; D007275:Injections, Intravenous; D007700:Kinetics; D008954:Models, Biological; D012756:Sheep / Q000378:metabolism*; D013432:Sulfathiazoles / Q000008:administration & dosage / Q000378:metabolism*; D013997:Time Factors; D014018:Tissue Distribution
chemical_list: D013432:Sulfathiazoles