[Prolactin secretion and synthesis by human somatotropin adenomas: in vitro effect of somatostatin (SRIF) (author's transl)].
Human somatotropin secreting adenomas removed from acromegalic patients were submitted to organ culture for periods of up 1 to 4 hours and 1 to 2 weeks. Prolactin (PRL) secretion increased in most of the experiments during the different culture times while growth hormone (GH) secretion decreased slowly in some of them. After incorporation of 3H leucine, 3H GH and 3H PRL were obtained in short and long term organ culture giving evidence for "de novo" synthesis. SRIF inhibited PRL as well as GH secretion after 1 to 4 hours incubation.
D000172:Acromegaly / Q000150:complications / Q000378:metabolism*; D000236:Adenoma / Q000150:complications / Q000378:metabolism*; D013006:Growth Hormone / Q000096:biosynthesis; D006801:Humans; D009924:Organ Culture Techniques; D011388:Prolactin / Q000096:biosynthesis / Q000378:metabolism*; D013004:Somatostatin / Q000378:metabolism / Q000494:pharmacology*
D013004:Somatostatin; D011388:Prolactin; D013006:Growth Hormone
Secrétion et synthèse de la prolactine par les adénomes somatotropes humains en culture organotypique. Effet de la somatostatine (SRIF).