title: Specific metabolic effects imposed by Streptococcus pneumoniae upon the response to femoral fracture in the rat.
abstract: The possible potentiation of an infection upon the metabolic consequences of trauma was tested in rats using a 2 X 2 block design which included control, femoral fracture, pneumococcal infection, and fracture plus infection groups. Infection introduced unique metabolic effects different from those of starvation, femoral fracture, or both together. Infection-induced effects included an accelerated conversion of 14C-alanine to glucose, higher serum haptoglobin, alpha2-macrofetoprotein, copper, and ceruloplasmin values, and lower serum iron, zinc, and transferrin concentrations. The first three of these infection-induced effects were diminished in rats with a femoral fracture. No measured effect of infection was increased in traumatized rats.
mesh_terms: D000818:Animals; D001798:Blood Proteins / Q000378:metabolism; D005264:Femoral Fractures / Q000150:complications / Q000378:metabolism*; D005943:Gluconeogenesis; D011008:Pneumococcal Infections / Q000150:complications / Q000378:metabolism*; D051381:Rats
chemical_list: D001798:Blood Proteins