[Pseudolupus induced by a vasculotropic drug (author's transl)].
The authors report eight cases of women suffering from pseudolupus erythematosus, with positive antimitochondrial antibodies. In six in the past history, a vasculotropic drug, Venocuran or Venopyridum, had been taken. All the patients had had episodes of fever, a pericarditis and/or myocarditis. A pleural effusion was present in six and pulmonary infiltrates in four. The course of the disease was for a limited period (1 to 3 months) in four cases and was chronic in the other four. One patient developed severe mitral incompetence and a cardiomyopathy.
D000328:Adult; D000368:Aged; D001323:Autoantibodies / Q000032:analysis*; D002301:Cardiac Glycosides / Q000009:adverse effects* / Q000627:therapeutic use; D002908:Chronic Disease; D003937:Diagnosis, Differential; D004338:Drug Combinations; D005260:Female; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000139:chemically induced* / Q000175:diagnosis; D008875:Middle Aged; D008928:Mitochondria / Q000276:immunology*; D010936:Plant Extracts / Q000009:adverse effects / Q000627:therapeutic use; D011720:Pyrazoles / Q000009:adverse effects* / Q000627:therapeutic use; D014665:Vasodilator Agents / Q000009:adverse effects* / Q000627:therapeutic use; D014689:Venous Insufficiency / Q000188:drug therapy
D001323:Autoantibodies; D002301:Cardiac Glycosides; D004338:Drug Combinations; D010936:Plant Extracts; D011720:Pyrazoles; D014665:Vasodilator Agents; C010644:Venocuran
Pseudo-lupus induit par un médicament vasculotrope.