Inhibition of experimental metastatic spread by nonspecific stimulants.
It has been demonstrated by a syngeneic metastatic model of the XVII mouse that pretreatment of the animals with BCG and Freund's adjuvant brings about a significant inhibition of metastatic growth. This inhibition is further increased by combined pretreatment with nonspecific stimulants and additional specific immunisation of the animals against the given tumor.
D000818:Animals; D000951:Antigens, Neoplasm / Q000008:administration & dosage; D001500:BCG Vaccine / Q000627:therapeutic use*; D005620:Freund's Adjuvant / Q000627:therapeutic use*; D007109:Immunity; D051379:Mice; D009362:Neoplasm Metastasis / Q000276:immunology / Q000628:therapy*; D012513:Sarcoma, Experimental / Q000276:immunology / Q000628:therapy*
D000951:Antigens, Neoplasm; D001500:BCG Vaccine; D005620:Freund's Adjuvant