title: [The jimpy mouse].
abstract: Ultrastructural study of the Jimpy mice shows lack of myelin in the central nervous system: low density of glial cells, defect of maturation of oligodendrocytes and deficiency in axonal growth. The lack of myelin is more proeminent in late myelinating structures: corpus callosum and corticospinal fasciculus. Failure in myelin is rather the consequence of an early interruption of myelination as that of demyelination (a destruction of the sheats).
mesh_terms: D000375:Aging; D000818:Animals; D001369:Axons / Q000473:pathology / Q000502:physiology; D003337:Corpus Callosum / Q000254:growth & development / Q000473:pathology; D003711:Demyelinating Diseases / Q000473:pathology / Q000662:veterinary*; D051379:Mice / Q000033:anatomy & histology*; D009186:Myelin Sheath / Q000166:cytology* / Q000502:physiology / Q000648:ultrastructure; D009413:Nerve Fibers, Myelinated / Q000473:pathology / Q000502:physiology; D009434:Neural Pathways; D009457:Neuroglia / Q000473:pathology; D012376:Rodent Diseases / Q000209:etiology / Q000473:pathology*; D013116:Spinal Cord / Q000473:pathology
vernacular_title: La souris jimpy.