Tamoxifen inhibition of an in vitro oestradiol-induced surface coat change on mouse blastocysts.
1. Eighty-nine hour post-coitus mouse blastocysts cultured in the presence of oestradiol-17beta underwent a histochemically detectable surface coat change. 2. Tamoxifen was found to inhibit this in vitro-induced change. The role of Tamoxifen as an inhibitor of implantation is discussed.
D000818:Animals; D001755:Blastocyst / Q000187:drug effects / Q000648:ultrastructure*; D004958:Estradiol / Q000494:pharmacology; D004965:Estrogen Antagonists; D066298:In Vitro Techniques; D051379:Mice; D013629:Tamoxifen / Q000494:pharmacology*; D013997:Time Factors
D004965:Estrogen Antagonists; D013629:Tamoxifen; D004958:Estradiol