[Effect of diazepam on the properties of an erythrocyte-plasma protein complex and the development of shock during the transfusion of heterogenic blood].
Preliminary administration of 2 mg/kg of diazepam eliminated the pyrogenic reaction and increased survival of rabbits following intravenous injection of cat blood to them. A study of physico-chemical properties of the blood by measurement of the ionization balance in thermal denaturing demonstrated that injection of heterogenous blood to rabbits and suspension of rabbit erythrocytes in cat plasma in vitro led to a sharp reduction of the rate of proton binding with plasma proteins in the presence of foreign erythrocytes. Preliminary administration of diazepam to rabbits, and diazepam addition to the cat plasma in vitro prevented such changes and promoted retention of normal blood properties. Addition of diazepam in a concentration of about 10--4 M to the heterogenous plasma decreased erythrocyte agglutination considerably.
D000818:Animals; D001787:Blood Group Incompatibility / Q000188:drug therapy; D001798:Blood Proteins / Q000494:pharmacology*; D002415:Cats; D003975:Diazepam / Q000494:pharmacology*; D004353:Drug Evaluation, Preclinical; D004912:Erythrocytes / Q000187:drug effects*; D066298:In Vitro Techniques; D011817:Rabbits; D012769:Shock / Q000188:drug therapy*; D065227:Transfusion Reaction; D014183:Transplantation, Heterologous
D001798:Blood Proteins; D003975:Diazepam
Vliianie diazepama na svoĭstva kompleksa éritrotsity-belki plazmy i razvitie shoka pri perelivanii geterogennoĭ krovi.