Induction of microcycle sporulation in Bacillus brevis spp. AG4 by amethopterin.
Addition of amethopterin to medium before inoculation inhibited DNA synthesis and induced microcycle sporogenesis in Bacillus brevis spp. AG4. Synthesis of RNA and proteins occurred at a considerably reduced rate.
D001407:Bacillus / Q000187:drug effects* / Q000502:physiology; D001426:Bacterial Proteins / Q000096:biosynthesis; D004269:DNA, Bacterial / Q000096:biosynthesis; D008727:Methotrexate / Q000494:pharmacology*; D012329:RNA, Bacterial / Q000096:biosynthesis; D013171:Spores, Bacterial
D001426:Bacterial Proteins; D004269:DNA, Bacterial; D012329:RNA, Bacterial; D008727:Methotrexate