Effects of various types of vagotomy on gastrin release and gastric secretion in dogs.
Changes of serum gastrin and acid secretory responses to histamine, feeding and insulin stimulation before and after various types of vagotomy (TV, SV, SPV and SAV) were investigated in Heidenhain pouch dogs. The following results were obtained: (1) The acid secretory response to histamine slightly decreased after various types of vagotomy. (2) The responses of serum gastrin and acid secretion to feeding were elevated after various types of vagotomy. (3) The serum gastrin response to insulin was highly increased after SPV and TV, whereas the response was slightly increased and decreased after SV and SAV, respectively. The acid secretion in response to insulin was increased only after SPV, while it was decreased after the other types of vagotomy. These results led to the condition that there might be no correlation between serum gastrin and acid secretory responses to feeding and insulin after various types of vagotomy.
D000818:Animals; D004285:Dogs; D004435:Eating; D005750:Gastric Juice / Q000378:metabolism*; D005755:Gastrins / Q000097:blood / Q000378:metabolism*; D006632:Histamine / Q000494:pharmacology; D007328:Insulin / Q000494:pharmacology; D014628:Vagotomy / Q000379:methods*
D005755:Gastrins; D007328:Insulin; D006632:Histamine