title: Comparative chromosome study of normal mammary tissue, carcinogen-induced mammary tumors, and hyperplastic alveolar nodules in the rat: Brief communication.
abstract: The chromosome constituents of 101 normal mammary gland cells, 122 hyperplastic alveolar nodule (HAN) cells, and 360 cells from eleven 7,12-dimethylbenz[a]anthracene (DMBA)-induced mammary tumors in the WF rat were examined. Both mammary gland and HAN had normal diploid karyotype patterns, whereas mammary tumors showed frequent (approximately 30%) abnormalities, e.g., aneuploidy, pseudodiploidy, polyploidy, and structural aberrations such as breakage and translocation. These results suggested that chromosome constituents of HAN cells are essentially the same as those of the normal mammary epithelial cells.
mesh_terms: D000818:Animals; D002869:Chromosome Aberrations; D004967:Estrogens / Q000494:pharmacology; D005260:Female; D006965:Hyperplasia; D008321:Mammary Glands, Animal / Q000187:drug effects / Q000648:ultrastructure*; D008325:Mammary Neoplasms, Experimental / Q000235:genetics* / Q000473:pathology; D011003:Ploidies; D011230:Precancerous Conditions / Q000235:genetics* / Q000473:pathology; D051381:Rats; D011920:Rats, Inbred WF
chemical_list: D004967:Estrogens