Possible linkage between the major histocompatibility complex and the immune response to factor VIII in classic haemophilia.
The pattern of HLA segregation was analyzed in 10 sibships of haemophilia A patients, each of which included 1 or 2 haemophilic brothers with an antibody to factor VIII. The observed HLA distribution is suggestive of a linkage between the major histocompatibility complex and a gene responsible for immune response to isologous factor VIII.
D005169:Factor VIII / Q000276:immunology*; D008040:Genetic Linkage; D006680:HLA Antigens; D006238:Haploidy; D006467:Hemophilia A / Q000276:immunology*; D006801:Humans
D006680:HLA Antigens; D005169:Factor VIII