Colorimetric assay of noramidopyrine methanesulfonate sodium in formulations and in blood and urine samples.
A simple, rapid, specific and sensitive colorimetric method is proposed for the quantitative estimation of noramido-pyrine methanesulfonate sodium in different dosage forms as well as in blood and urine samples. The method is based on the reaction of 3-sulfonic-5-amino-alpha-naphthol with formaldehyde liberated from noramidopyrine methanesulfonate sodium after treatment with conc. sulfuric acid where a yellow colour appeared immediately which turned to blue on dilution with water. The blue colour obeyed Beer's law (10--400 microgram) and remained stable for more than 1 h. The effect of other drugs, tablet excipients, parentral vehicles and suppository bases was studied.
D000632:Aminopyrine / Q000031:analogs & derivatives*; D003124:Colorimetry / Q000379:methods*; D004177:Dipyrone / Q000032:analysis* / Q000097:blood / Q000652:urine; D006801:Humans; D007267:Injections; D013488:Suppositories; D013607:Tablets
D013488:Suppositories; D013607:Tablets; D000632:Aminopyrine; D004177:Dipyrone