Linoleic acid and susceptibility to fatal ventricular fibrillation in rats.
The effect of linoleic acid on the induction of fatal ventricular fibrillation by intravenous CaCl2 (10%), was studied in rats fed for a month from weaning on a diet with either a high or low content of linoleic acid. Studies were performed in the basal state and after pretreatment with noradrenaline, which increased the sensitivity to CaCl2 equally in animals from both diet groups. Despite considerable differences in the linoleic acid levels in the plasma and myocardium, the two groups did not differ in the incidence of fatal ventricular fibrillation. Our conclusions concerning the effect of linoleic acid on cardiac arrhythmias, and sudden death in particular, are compared with those from other studies.
D000818:Animals; D002122:Calcium Chloride; D004041:Dietary Fats / Q000378:metabolism; D005230:Fatty Acids, Nonesterified / Q000097:blood; D006321:Heart / Q000187:drug effects; D008041:Linoleic Acids / Q000378:metabolism*; D008297:Male; D009638:Norepinephrine / Q000494:pharmacology; D051381:Rats; D014280:Triglycerides / Q000097:blood; D014693:Ventricular Fibrillation / Q000139:chemically induced / Q000209:etiology*
D004041:Dietary Fats; D005230:Fatty Acids, Nonesterified; D008041:Linoleic Acids; D014280:Triglycerides; D002122:Calcium Chloride; D009638:Norepinephrine