title: [Use of citiolone in chronic hepatitides. Results of a research with clinical and laboratory controls].
abstract: The therapeutic possibilities offered by the use of a new substance, 3-acetamido-2-oxo-tetrahydro-thiophene or citiolone, in two groups of patients, the first suffering from persistent chronic hepatitis, the second from aggressive chronic hepatitis and-or compensated cirrhosis diagnosed on the basis of clinical, laboratory, and bioptic findings have been studied. The experiment was of "between patients" pattern and findings were obtained with the double-blind method. Tests were compared with a placebo and all patients were treated with a basic therapy consisting of a polyvitaminic complex. In both groups, the results confirmed the therapeutic effectiveness of the new substance and this was demonstrable, including statistically, in an improvement in the clinical picture and, above all, in certain liver function exploration tests. At termination of the treatment cycle, liver biopsies were carried out in certain patients and these showed an improvement in the liver cell picture.
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D002908:Chronic Disease; D004341:Drug Evaluation; D005260:Female; D006505:Hepatitis / Q000188:drug therapy* / Q000201:enzymology; D006525:Hepatitis, Viral, Human / Q000188:drug therapy; D006801:Humans; D007770:L-Lactate Dehydrogenase / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D012106:Research; D013876:Thiophenes / Q000008:administration & dosage / Q000627:therapeutic use*; D000637:Transaminases / Q000378:metabolism
chemical_list: D013876:Thiophenes; C000486:citiolone; D007770:L-Lactate Dehydrogenase; D000637:Transaminases
vernacular_title: Impiego del citiolone nelle epatiti croniche. Risultato di una ricerca con controlli clinici e laboratoristici.