title: [Studies on the tolerance of the organism to X 5 CrNiMo 18.10 steel (Königsee). I. Detection of chrome and nickel traces in the spleen, liver, kidney and in the tissues surrounding metallic implants (X 5 CrNiMo 18.10 steel) in guinea pigs by means of flameless atomic absorption spectrophotometry].
abstract: Small bars of X 5 CrNiMo 18.10-steel were implanted under the dorsal muscles of 60 guinea-pigs, a number of which was preoperatively sensibilized against potassium-bichromate or nickel-II-sulfate. After various times of surviving the traces of chromium and nickel were assessed in the tissue around the graft, in spleen, liver, and kidney. The resulting values ranged widely, there was a tendency to increased values the longer the implantates remained in the tissue. Traces of the elements were also found in the organs of the guinea-pigs. After sensibilization, the animals showed no more aggressive behavior against the implantates than without sensibilization. The quality of the implantates' surface is more important - as to coming-off parts of the alloy by corroding - than the preoperative immune condition of the organism.
mesh_terms: D001672:Biocompatible Materials; D002857:Chromium / Q000032:analysis; D004342:Drug Hypersensitivity / Q000276:immunology*; D004343:Drug Implants; D007668:Kidney / Q000032:analysis; D008099:Liver / Q000032:analysis; D008670:Metals / Q000032:analysis*; D009132:Muscles / Q000032:analysis; D009532:Nickel / Q000032:analysis; D013054:Spectrophotometry, Atomic; D013154:Spleen / Q000032:analysis
chemical_list: D001672:Biocompatible Materials; D004343:Drug Implants; D008670:Metals; D002857:Chromium; D009532:Nickel
vernacular_title: Untersuchungen zur Verträglichkeit des X 5 CrNiMo 18.10 Stahls (Königsee) im Organismus. Teil I: Bestimmung von Chrom- und Nickelspuren in der Milz, Leber, Niere und im Umgebungsgewebe metallischer Implantate (X 5 CrNiMo 18.10 Stahl) von Meerschweinchen mit Hilfe der flammenlosen Atomabsorptionsspektralphotometrie.