Spontaneous hypertension and hypertensive vascular disease in the NZB strain of mice.
NZB nice spontaneously develop a high blood pressure and hypertensive vascular disease in the heart and the kidney. Treatment with cyclophosphamide decreased the level of blood pressure; congenital athymic nude NZB mice failed to develop a high blood pressure. These findings suggest that thymus and the thymus-dependent immune reactions have pathogenic importance for the spontaneous hypertension in these mice.
D000818:Animals; D002318:Cardiovascular Diseases / Q000209:etiology* / Q000473:pathology; D003520:Cyclophosphamide / Q000494:pharmacology; D005260:Female; D006973:Hypertension / Q000209:etiology / Q000473:pathology / Q000662:veterinary*; D008297:Male; D051379:Mice; D008814:Mice, Inbred NZB; D008819:Mice, Nude; D012376:Rodent Diseases; D013950:Thymus Gland / Q000502:physiology / Q000637:transplantation
D003520:Cyclophosphamide