title: On the cause of the increased Heidenhain pouch secretion and serum gastrin concentration after gastrojejunostomy in dogs. With a statistical appendix.
abstract: In 10 dogs with Heidenhain pouches (HP) a gastrojejunostomy (GEA) was constructed and later converted into a Roux en-Y anastomosis in order to abolish or reduce transstomal reflux. Next, duodenal inhibition was abolished by duodenal transection, and finally the duodenal bulb was excised. Twenty-four hour HP acid output increased after GEA, some 70% of the increase being attributable to transstomal reflux, the rest to decreased duodenal inhibition. Abolished duodenal inhibition caused a new rise, not significantly different from that caused by the combined effect of reflux and decreased duodenal inhibition after GEA. Twenty-four hour fasting HP acid output and 5 hr food-stimulated HP acid output rose after GEA by the same amount as that caused by abolished duodenal inhibition. A significant correlation was found between integrated gastrin and total HP acid output after food stimulation. Both fasting and food-stimulated gastrin concentration rose after GEA, the latter caused by reflux alone. Elimination of duodenal inhibition caused an unexpected rise in both fasting and food-stimulated gastrin concentration.
mesh_terms: D000818:Animals; D004285:Dogs; D004386:Duodenum / Q000601:surgery; D005215:Fasting; D005502:Food; D005746:Gastric Emptying; D005750:Gastric Juice / Q000378:metabolism*; D005755:Gastrins / Q000097:blood*; D005763:Gastroenterostomy; D005769:Gastrointestinal Motility; D007583:Jejunum / Q000601:surgery; D013223:Statistics as Topic; D013270:Stomach / Q000601:surgery
chemical_list: D005755:Gastrins