Familial balanced reciprocal translocation t(1;16) (q12;p13) ascertained because of multiple abortions in a carrier.
A familial balanced reciprocal translocation was ascertained through a female carrier whose last three pregnancies ended in missed abortions. Five translocation carriers were detected in three generations among 9 family members investigated. The translocation could be the cause for the abortions of the proposita and her cousin's wife.
D000030:Abortion, Missed / Q000235:genetics*; D002900:Chromosomes, Human, 1-3; D002901:Chromosomes, Human, 13-15; D002906:Chromosomes, Human, 6-12 and X; D005260:Female; D006801:Humans; D011247:Pregnancy; D014178:Translocation, Genetic