Elevated fecal levels of endogenous pancreatic endopeptidases after antibiotic treatment.
Feces from normal and antibiotic-treated persons were analyzed for the content of immunoreactive trypsin and elastase. In the control group the mean concentration of immunoreactive trypsin was 13 microgram per g feces as compared to 147 in the antibiotic-treated group. Elastase was demonstrable in only 3 of 30 samples in the control group but in 20 of 26 in the antibiotic-treated group. The decreased inactivation of pancreatic proteases must depend on an altered intestinal microflora. The results suggest that reestablishment of a normal enteric flora may take months after the short time oral administration of antibiotics.
D000900:Anti-Bacterial Agents / Q000009:adverse effects* / Q000627:therapeutic use; D004318:Doxycycline / Q000009:adverse effects; D005243:Feces / Q000201:enzymology*; D006801:Humans; D010196:Pancreatic Elastase / Q000032:analysis*; D010189:Pancreatic Juice / Q000201:enzymology*; D010406:Penicillins / Q000009:adverse effects; D013752:Tetracycline / Q000009:adverse effects; D014357:Trypsin / Q000032:analysis*
D000900:Anti-Bacterial Agents; D010406:Penicillins; D010196:Pancreatic Elastase; D014357:Trypsin; D013752:Tetracycline; D004318:Doxycycline