title: [Assessment of the safety of nonachlazin during long term administration].
abstract: Tests were set up on rats, guinea pigs and dogs to look into the cronic toxicity of nonachlazine, an effective antianginal agent, used for a space of 6 months in doses of 10 and 35 mg/kg, by far superior to the ones effectively employed clinically. The results of hematological, morphological and biochemical investigations bear evidence to a low toxicity of nonachlozine, which gives good reason to presume the drug to be safe for the use in medical practice.
mesh_terms: D000311:Adrenal Glands / Q000473:pathology; D000818:Animals; D056486:Chemical and Drug Induced Liver Injury; D004285:Dogs; D006168:Guinea Pigs; D006331:Heart Diseases / Q000139:chemically induced; D006965:Hyperplasia / Q000139:chemically induced; D007674:Kidney Diseases / Q000139:chemically induced; D008206:Lymphatic Diseases / Q000139:chemically induced; D051381:Rats; D013950:Thymus Gland; D014665:Vasodilator Agents / Q000633:toxicity*
chemical_list: D014665:Vasodilator Agents
vernacular_title: K otsenke bezopasnosti nonakhlazina pri ego dlitel'nom primenenii.