title: [Metabolism of the neuroleptic azabutyrone in the human body].
abstract: Thin-layer and gas chromatography, spectrophotometry and mass-spectrometry were employed in studying metabolism of the neuroleptic azabutyron in man. It was ascertained that azabutyron is eliminated from the human organism in 24 hours unchanged (10 per cent of the dose administered). The main ways of its metabolism are oxidative N-dealkylation, reduction of the carboxylic group in the molecule, N-oxidation and conjugation of the drug.
mesh_terms: D001372:Aza Compounds / Q000378:metabolism; D001711:Biotransformation; D002090:Butyrophenones / Q000378:metabolism*; D006801:Humans; D014149:Tranquilizing Agents / Q000378:metabolism*
chemical_list: D001372:Aza Compounds; D002090:Butyrophenones; D014149:Tranquilizing Agents
vernacular_title: Metabolizm neĭroleptika azabutirona v organizme cheloveka.