[Studies on sulfhemoglobin formation by various drugs (2) (author's transl)].
Sulfhemoglobin (SHb) and methemoglobin (MHb) formations by various aniline erivatives were examined by a single and three consecutive intraperitoneal administrations to mice. It was found that with a single administraion, methemoglobinemia was induced by aniline, 2-methylaniline, 3-methylaniline, 4-methylaniline, 3-trifluoromethylaniline (3-TFMA), 4-trifluoromethylaniline (4-TFMA), 2, 3-dichloroaniline, 2-aminopehnol, acetanilide (AA), 2-hydroxyacetanilide, N-methylaniline (NMA), N,N-dimethylaniline (NDMA), N-ethylaniline (NEA) and N,N-diethylaniline, and was not observed with 2, 3-dimethylanilnie, 2-trifluoromethylaniline, 3-aminophenol, 4-aminophenol, 2. 6-dichloroaniline, 3-hydroxyacetanilide (3-HAA), 4-hydroxyacetanilide (4-HAA), 2-aminobenzoic acid, 3-aminobenzoic acid, 4-aminobenzoic acid and 4-chloro-2-aminobenzoic acid. On the other hand, sulfhemoglobinemia which appeared much more delayed than MHb, with a single administration, was found to be induced by 3-TFMA, 4-TFMA and NMA. Furthermore, with three consecutive administrations, such was induced by AA, 3-HAA, NDMA and NEA even though SHb was not demonstrated with a single administration. Structure-SHb and MHb forming property relationships were discussed.
D000814:Aniline Compounds / Q000494:pharmacology*; D000818:Animals; D008297:Male; D008706:Methemoglobin / Q000096:biosynthesis; D008708:Methemoglobinemia / Q000139:chemically induced; D051379:Mice; D013329:Structure-Activity Relationship; D013435:Sulfhemoglobin / Q000096:biosynthesis*; D013436:Sulfhemoglobinemia / Q000139:chemically induced; D013997:Time Factors
D000814:Aniline Compounds; D008706:Methemoglobin; D013435:Sulfhemoglobin