[Cytogenetic study of the mutagenic properties of the repellents dimethyl phthalate and phenoxyacetic acid N,N-diethylamide].
Animal experiments ascertained that the repellent N,N-diethylamide of phenoxyacetic acid (P-203) increases the frequency of chromosomal aberration in the bone marrow cells of mice following its intraperitoneal introduction and also in the cells of a regenerating liver of rats after its repeated skin application. Dimethylphthalate displayed a mutagenic action only with respect to the rats' hepatocytes when applied repeatedly to the skin.
D000287:Administration, Topical; D000818:Animals; D001853:Bone Marrow / Q000187:drug effects; D001854:Bone Marrow Cells; D002869:Chromosome Aberrations; D006016:Glycolates / Q000633:toxicity*; D007274:Injections, Intraperitoneal; D007302:Insect Repellents / Q000008:administration & dosage / Q000633:toxicity*; D008099:Liver / Q000187:drug effects; D008115:Liver Regeneration; D008297:Male; D051379:Mice; D010642:Phenoxyacetates / Q000008:administration & dosage / Q000633:toxicity*; D010795:Phthalic Acids / Q000008:administration & dosage / Q000633:toxicity*
D006016:Glycolates; D007302:Insect Repellents; D010642:Phenoxyacetates; D010795:Phthalic Acids
Tsitogeneticheskoe issledovanie mutagennykh svoĭstv repellentov dimetilftalata i N,N-diétilamida fenoksiuksusnoĭ kisloty.