Permeability of the mitochondrial membrane to bicarbonate ions.
Osmotic-swelling techniques show that HCO3- enters mitochondria by an electrogenic process, effectively HCO3- uniport, under non-energized conditions. This mode of translocation accounts for previous reports of non-entry of HCO3- in experiments with energy-linked Ca2+ uptake. The effects of HCO3- on mitochondrial respiration are reported and discussed.
D000818:Animals; D001639:Bicarbonates / Q000378:metabolism*; D066298:In Vitro Techniques; D008564:Membrane Potentials; D008930:Mitochondria, Liver / Q000378:metabolism*; D008933:Mitochondrial Swelling; D010539:Permeability; D051381:Rats
D001639:Bicarbonates