Predictibility of the stability constant of a radium-cryptate by means of in vivo data from radioactive alkaline earthes.
By means of a formula, developed by J. Schubert[9] and A. Catsch, H.J. Heller[3] as well as a relation postulated by A. Catsch[1] the "thermodynamic" stability constant of the Radium (222)-cryptate (KRaRa(222) was calculated from measurements of the total body retention of the total body retention of the radioactive alkaline earthes 85SR, 140Ba and 224Ra and its (222)-cryptates in rats [5-7]. From the same in vivo data a direct lineary relationship between the log of the effectiveness quotient, log EQM(222), and the log of the "thermodynamic" stability log KMM(222) was found graphically. The values from the graph correspond with those of the calculation.
D000818:Animals; D004355:Drug Stability; D006207:Half-Life; D007726:Krypton; D008433:Mathematics; D008673:Metals, Alkaline Earth; D011883:Radium; D051381:Rats
D008673:Metals, Alkaline Earth; D007726:Krypton; D011883:Radium