The investigation of collagen induced platelet aggregation by the screen filtration pressure technique.
A modification of the screen filtration pressure technique has been developed to allow platelet response to collagen to be measured. Using a commercial collagen suspension this method has been found to be both simple to perform and to give highly reproducible results. Changes in platelet response to collagen after administration of acetylsalicyclic acid were clearly detected and this suggests that collagen screen filtration pressure may provide a sensitive method for evaluating the effect of platelet release inhibiting drugs.
D001241:Aspirin / Q000494:pharmacology; D001772:Blood Cell Count; D003094:Collagen / Q000494:pharmacology*; D004906:Erythrocyte Count; D005374:Filtration / Q000379:methods*; D006801:Humans; D010974:Platelet Aggregation / Q000187:drug effects*; D011312:Pressure; D013696:Temperature; D013997:Time Factors
D003094:Collagen; D001241:Aspirin