[Radioimmunological and biochemical study of the reaction of the adenohypophysis, testes and adrenals in rats and guinea pigs to the administration of the antiandrogen, 4-nitro-3-trifluoromethylisobutyranilide].
A study was made of the influence of antiandrogen 4'-nitro-3'-trifluorome-thylisobutyranilide (niftolide) on the content of the luteinizing hormone, testosterone and corticosterone in the rat blood plasma, the content of testosterone in the blood plasma and on the 17-OCS and 17-KS urinary excretion in guinea pigs. The data obtained pointed to a marked intensification of lutropin and testosterone secretion. The observed changes are explained by the capacity of niftolide to block the inhibitory influence of the androgens of the feed-back mechanism of the gonadotropin secretion control. It is suggested that niftolide can be used for the investigation of the functional condition of the hypothalamo-hypophysio-testicular system. Niftolide had no effect on the indices of the glucocorticoid activity of the adrenal glands in rats and guinea pigs.
D015065:17-Hydroxycorticosteroids / Q000652:urine; D015068:17-Ketosteroids / Q000652:urine; D000302:Adrenal Cortex / Q000187:drug effects*; D000813:Anilides / Q000494:pharmacology*; D000818:Animals; D002850:Chromatography, Gel; D002940:Circadian Rhythm; D005485:Flutamide / Q000494:pharmacology*; D006168:Guinea Pigs; D007986:Luteinizing Hormone / Q000097:blood; D008297:Male; D009929:Organ Size / Q000187:drug effects; D010903:Pituitary Gland, Anterior / Q000187:drug effects*; D011863:Radioimmunoassay; D051381:Rats; D013737:Testis / Q000187:drug effects*; D013739:Testosterone / Q000097:blood; D013997:Time Factors
D015065:17-Hydroxycorticosteroids; D015068:17-Ketosteroids; D000813:Anilides; D013739:Testosterone; D005485:Flutamide; D007986:Luteinizing Hormone
Radioimmunologicheskoe i biokhimicheskoe issledovanie reaktsii adenogipofiza, semennikov i nadpochechnikov krys i morskikh svinok na vvedenie antiandrogena 4-nitro-3-triftormetilizobutiranilida.