Dibenz[b,e]oxepinalkanoic acids as nonsteroidal antiinflammatory agents. 3. omega-(6,11-Dihydro-11-oxodibenz[b,e]oxepin-2-yl)alkanoic acids.
Omega-(6,11-Dihydro-11-oxodibenz[b,e]oxepin-2-yl)butyric, -hexanoic, and -octanoic acids were evaluated in the carrageenan paw edema assay. The most active compound, the butyric acid analogue, was 1.80 times more potent than the hexanoic compound, 1.15 times more potent than the octanoic analogue, and 0.43 times as potent as indomethacin.
D000818:Animals; D000893:Anti-Inflammatory Agents / Q000138:chemical synthesis* / Q000627:therapeutic use; D002264:Carboxylic Acids / Q000138:chemical synthesis / Q000627:therapeutic use; D003990:Dibenzoxepins / Q000138:chemical synthesis* / Q000627:therapeutic use; D004487:Edema / Q000188:drug therapy; D051381:Rats; D013329:Structure-Activity Relationship
D000893:Anti-Inflammatory Agents; D002264:Carboxylic Acids; D003990:Dibenzoxepins