Pharmacodynamics and pharmacokinetics of psycholeptic drugs in the course of radiation disease.
The effect of metanabol (1 mg per kg) applicated to rats during 10 days before irradiation (600 R) on pharmacodynamics and some indices of thioridazine kinetics was investigated. It was found that the increased cataleptic action of thioridazine (20 mg per kg), during radiation disease was inhibited ater metanabol premedication. The protective effect of metanabol was found to be due to shortening of the half-life time of thioridazine (from 5.5 h in irradiated to 2.38 h in irradiated premedicated animals) as well as to lowering of thioridazine content in the brain tissue.
D000818:Animals; D001646:Bile / Q000032:analysis; D001923:Brain Chemistry; D006207:Half-Life; D007700:Kinetics; D008297:Male; D008696:Methandrostenolone / Q000494:pharmacology*; D011833:Radiation Injuries, Experimental / Q000378:metabolism*; D011837:Radiation-Protective Agents / Q000494:pharmacology*; D051381:Rats; D013881:Thioridazine / Q000032:analysis / Q000037:antagonists & inhibitors* / Q000097:blood
D011837:Radiation-Protective Agents; D008696:Methandrostenolone; D013881:Thioridazine