[The influence of biophysical factors on biological oxidation and redox processes. 16. The possibility of influencing flavine coenzymes in liver mitochondria by means of ultrasonic treatment (author's transl)].
The quantity of FAD and FMN in mitochondria isolated from the liver of albino rats was determined before and after application of ultrasonic energy with the intensities 0,2,0,6 and 1,0 w/cm2 in a short-term test, and the intensity 0,2 w/cm2 applied at ten successive days in a long-term test. The total amount of the two coenzymes as well as their percentages were ascertained. The following results derive from our experiments: 1. A quantitative increase of FAD in liver mitochondria. This suggests that the capacity of the shortened respiratory chain has increased, since redox systems represent a factor determining its stage. 2. The flavine-mononucleotide responds to ultrasonics as a relatively instable biological macromolecule. 3. The total amount of flavine coenzymes is influenced especially by the quantity of FAD, and, correspondingly, by changes of the latter.
D000818:Animals; D005486:Flavin Mononucleotide / Q000378:metabolism*; D005182:Flavin-Adenine Dinucleotide / Q000378:metabolism*; D066298:In Vitro Techniques; D008930:Mitochondria, Liver / Q000201:enzymology*; D051381:Rats; D014465:Ultrasonics
D005182:Flavin-Adenine Dinucleotide; D005486:Flavin Mononucleotide
Der Einfluss biophysikalischer Faktoren auf die biologische Oxidation und die Redoxprozesse 16. Uber die Möglichkeit einer Beeinflussung der Flavin-Coenzyme in den Mitochondrien der Leber durch Ultraschallapplikation.