[Effect of immobilized noradrenaline on the contact phase of blood coagulation].
Specificity of interaction between factors of contact phase of blood coagulation and noradrenaline was studied. Human blood plasma lost the capacity to contact activation after chromatography on a column with noradrenaline-Sepharose. High specificity in binding of factors of contact phase with ligand-noradrenaline, "utilization" of factor XII during interaction with the ligand, the high specific activity of factor XII bound to noradrenaline-Sepharose were observed.
D001777:Blood Coagulation / Q000187:drug effects*; D001966:Bromine; D055598:Chemical Phenomena; D002621:Chemistry; D003486:Cyanides; D005174:Factor XII / Q000378:metabolism*; D006801:Humans; D009638:Norepinephrine / Q000494:pharmacology*; D012685:Sepharose
D003486:Cyanides; D005174:Factor XII; D012685:Sepharose; D001966:Bromine; D009638:Norepinephrine
Vliianie immobilizovannogo noradrenalina na kontaktnuiu fazu svertyvaniia krovi.