Effects of nomifensine in vitro on uptake of 5-hydroxytryptamine and dopamine into human platelets.
1. The effect of nomifensine on the uptake of 5-hydroxytryptamine (5-HT) and dopamine (DA) into human platelet-rich plasma has been studied. 2. A significant inhibition of DA uptake was observed at nomifensine 10(-6) M. 3. 5-HT uptake was significantly inhibited only at nomifensine 10(-4) M or more. 4. These results are consistent with those from previous animal experiments and suggest that the human platelet may be used as a model for studying DA uptake as well as that of 5-HT.
D001792:Blood Platelets / Q000187:drug effects* / Q000378:metabolism; D002997:Clomipramine / Q000494:pharmacology; D004298:Dopamine / Q000097:blood*; D005260:Female; D006801:Humans; D066298:In Vitro Techniques; D007546:Isoquinolines / Q000494:pharmacology*; D008297:Male; D009627:Nomifensine / Q000494:pharmacology*; D012701:Serotonin / Q000097:blood*
D007546:Isoquinolines; D009627:Nomifensine; D012701:Serotonin; D002997:Clomipramine; D004298:Dopamine