The spinal abnormalities in thalidomide embryopathy.
In 1968 a study was made of the spinal changes in 32 children with multiple congenital abnormalities due to thalidomide. Twenty-eight of these children have been traced and their spinal changes reviewed. Only four patients had normal spines on radiography. In eight children, scoliosis was present and had progressed though it was still of mild degree. Disc and end-plate abnormalities were seen in 14 children, and in some appeared to be progressive, leading to intervertebral fusion.
D000014:Abnormalities, Drug-Induced / Q000000981:diagnostic imaging*; D000015:Abnormalities, Multiple; D000293:Adolescent; D002648:Child; D005500:Follow-Up Studies; D006801:Humans; D011859:Radiography; D012600:Scoliosis / Q000151:congenital / Q000000981:diagnostic imaging; D013131:Spine / Q000002:abnormalities*; D013792:Thalidomide / Q000009:adverse effects*
D013792:Thalidomide