title: [Stability of glucose-6-phosphate dehydrogenase in aging of human diploid cells and the laboratory mouse].
abstract: Glucose 6-phosphate dehydrogenase (E. C. 1.1.1.49) was found to be inactivated by 30% for 25 min the incubation at 37 degrees C in extracts of human diploid cells and mouse liver, and the stability of the enzyme was found to reduce in aging of human diploid cells and mouse. The stability of dehydrogenase of mice treated with "geroprotector", 2-ethyl-6-methyl-3-hydroxypyridine, exceeds the control level.
mesh_terms: D000375:Aging; D000818:Animals; D004171:Diploidy; D004355:Drug Stability; D005954:Glucosephosphate Dehydrogenase / Q000378:metabolism*; D006801:Humans; D008099:Liver / Q000201:enzymology*; D051379:Mice; D010847:Picolines / Q000031:analogs & derivatives* / Q000494:pharmacology
chemical_list: D010847:Picolines; D005954:Glucosephosphate Dehydrogenase; C009820:6-methyl-2-ethyl-3-hydroxypyridine
vernacular_title: Izmenenie stabil'nosti gliukozo-6-fosfat-degidrogenazy pri starenii diploidnykh kletok cheloveka i laboratornykh myshei.