Prostaglandin and nerve-mediated response of the rabbit eye to argon laser irradiation of the iris.
Irradiation of the pigmented rabbit iris with a moderately low dose of argon laser light (5 applications of 750 mW, 500 micron, 0.5 sec) caused an immediate ocular response consisting of miosis, a rise of intra-ocular pressure and is accompanied by a disruption of the blood-aqueous barrier. Prostaglandin-like material was present in the aqueous humour withdrawn 60 minutes after irradiation. Prior treatment with indomethacin intravenously (20 mg/kg) or benoxinate topically (Novesine; 0.4%) greatly reduced the response and the combined use of the two drugs virtually abolished the ocular changes.
D000287:Administration, Topical; D000779:Anesthetics, Local / Q000494:pharmacology*; D000818:Animals; D001082:Aqueous Humor / Q000032:analysis; D005451:Fluorescein Angiography; D007213:Indomethacin / Q000008:administration & dosage / Q000494:pharmacology*; D007275:Injections, Intravenous; D007429:Intraocular Pressure / Q000187:drug effects; D007498:Iris / Q000187:drug effects / Q000293:injuries*; D007500:Iritis / Q000209:etiology; D007834:Lasers / Q000009:adverse effects*; D011453:Prostaglandins / Q000032:analysis / Q000378:metabolism*; D011817:Rabbits
D000779:Anesthetics, Local; D011453:Prostaglandins; D007213:Indomethacin