Treatment of advanced breast cancer with chemotherapeutics and inhibition of coagulation and fibrinolysis.
A case of advanced breast cancer with cerebral metastasis and pleurisy is reported in which irradiation and cytostatics had failed to retard progressive growth and spread of the tumour. Adjuvant therapy with heparin combined with the fibrinolytic inhibitor tranexamic acid was followed by regression of the cerebral metastasis as well as the pleurisy. When last seen one year later, the patient was free from symptoms.
D000925:Anticoagulants / Q000627:therapeutic use; D000933:Antifibrinolytic Agents / Q000627:therapeutic use; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D001777:Blood Coagulation / Q000187:drug effects*; D001932:Brain Neoplasms / Q000188:drug therapy; D001943:Breast Neoplasms / Q000188:drug therapy*; D005260:Female; D005342:Fibrinolysis / Q000187:drug effects*; D006493:Heparin / Q000627:therapeutic use; D006801:Humans; D008875:Middle Aged; D009362:Neoplasm Metastasis; D010998:Pleurisy / Q000188:drug therapy; D014148:Tranexamic Acid / Q000627:therapeutic use
D000925:Anticoagulants; D000933:Antifibrinolytic Agents; D000970:Antineoplastic Agents; D014148:Tranexamic Acid; D006493:Heparin