title: Continuous methotraxate intra-arterial infusion in the treatment of head and neck cancer.
abstract: Fifty-nine patients with malignant tumours on the head and neck area, were treated with continuous intra-arterial infusion of methotrexate into the external carotid artery from a catheter introduced through the superficial temporal artery. Each patient received intramuscular injections of folinic acid in a dosage of 6mg every 6 hours, and a total dose of 250mg of methotrexate during a five day treatment period. The patients had received no previous chemotherapy, radiotherapy nor surgery. Forty-four of the fifty-nine patients (74.5%) responded partially to treatment and three had complete remissions. No recurrence was observed after a follow-up of more than eight months. Twelve patients showed no response at all.
mesh_terms: D000328:Adult; D000368:Aged; D002342:Carotid Artery, External; D005260:Female; D006258:Head and Neck Neoplasms / Q000188:drug therapy*; D006801:Humans; D007263:Infusions, Parenteral; D008297:Male; D008727:Methotrexate / Q000008:administration & dosage* / Q000627:therapeutic use; D008875:Middle Aged
chemical_list: D008727:Methotrexate