Vascular reactions to horseradish peroxidase in the guinea pig.
Albino guinea pigs were given intradermal injections of the protein tracer horseradish peroxidase. In a 0.1 mM concentration the tracer did not increase vascular permeability to Evans blue-labelled plasma proteins. In a 1 mM concentration, however, the peroxidase induced a local vascular leakage. This leakage was almost totally inhibited by pretreating the animals with acetylsalicylic acid, while antihistamine had only a weak inhibitory effect. We therefore believe that prostaglandins are important mediators in this HRP-induced vascular reaction.
D000818:Animals; D002199:Capillary Permeability / Q000187:drug effects*; D005260:Female; D006168:Guinea Pigs; D006632:Histamine; D006651:Histocytochemistry; D006735:Horseradish Peroxidase / Q000494:pharmacology*; D008297:Male; D010544:Peroxidases / Q000494:pharmacology*; D011738:Pyrilamine / Q000494:pharmacology; D012867:Skin / Q000098:blood supply*
D006632:Histamine; D006735:Horseradish Peroxidase; D010544:Peroxidases; D011738:Pyrilamine