Acidosis, alkalosis, and aqueous humor dynamics in rabbits.
Systemic acidosis induced by intravenous administration of hydrochloric acid lowered intraocular pressure in unanesthetized rabbits. Aqueous humor flow was reduced by approximately 50%, as measured by the iodide method and as calculated from tonographic data. Outflow facility, episcleral venous pressure, plasma osmolality, blood pressure, pulse, and body temperature were not altered by systemic acidosis. Systemic alkalosis induced by intravenously administered sodium bicarbonate was associated with an increased intraocular pressure. Aqueous humor flow following systemic alkalosis was increased by approximately 100%, as measured by the iodide method and as calculated from tonographic data. Alkalosis was not associated with alterations in outflow facility, episcleral venous pressure, plasma osmality, blood pressure, pulse, or rectal temperature.
D000138:Acidosis / Q000139:chemically induced*; D000471:Alkalosis / Q000139:chemically induced*; D000818:Animals; D001082:Aqueous Humor / Q000502:physiology*; D001639:Bicarbonates / Q000494:pharmacology; D001794:Blood Pressure / Q000187:drug effects; D001831:Body Temperature / Q000187:drug effects; D006851:Hydrochloric Acid / Q000494:pharmacology; D007429:Intraocular Pressure / Q000187:drug effects*; D008297:Male; D009994:Osmolar Concentration; D011674:Pulse / Q000187:drug effects; D011817:Rabbits; D014690:Venous Pressure / Q000187:drug effects
D001639:Bicarbonates; D006851:Hydrochloric Acid