A pharmacological study of SRS-A on the bovine cutaneous vasculature.
Bovine slow-reacting substance of anaphylaxis (SRS-A) is capable of producing dose-dependent vascular permeability changes in the skin of calves. The wheals are well-defined indurations, similar to wheals induced by histamine but different from those induced by prostaglandin (PG) E2. Three proposed SRS-A receptor blockers (i.e., FPL 55712, PR-D-92-EA, and sodium meclofenamate) were studied with respect to their antagonism of wheals induced by SRS-A, histamine, and PGE2. PR-D-92-EA and FPL 55712 antagonized SRS-A, and also histamine and PGE2 at high concentrations. Meclofenamate was ineffective against SRS-A but antagonized histamine and PGE2 at higher concentrations. The significance of these results, especially with respect to passive cutaneous anaphylaxis, is discussed.
D000818:Animals; D002199:Capillary Permeability / Q000187:drug effects*; D002417:Cattle; D006168:Guinea Pigs; D006632:Histamine / Q000494:pharmacology; D006633:Histamine Antagonists; D007082:Ileum / Q000187:drug effects; D066298:In Vitro Techniques; D008297:Male; D008469:Meclofenamic Acid / Q000494:pharmacology; D009119:Muscle Contraction / Q000187:drug effects; D009130:Muscle, Smooth / Q000187:drug effects; D010323:Passive Cutaneous Anaphylaxis / Q000187:drug effects; D011458:Prostaglandins E / Q000037:antagonists & inhibitors / Q000494:pharmacology; D013189:SRS-A / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D012867:Skin / Q000098:blood supply*
D006633:Histamine Antagonists; D011458:Prostaglandins E; D013189:SRS-A; D008469:Meclofenamic Acid; D006632:Histamine