title: Total body protein catabolism in starved and infected rats.
abstract: The catabolic effects of starvation alone, or starvation in the presence of pneumococcal sepsis, were compared in rats whose skeletal muscle protein had been tagged 14 days earlier with 14C-phenylalanine. In a fed rat, protein catabolism (as estimated by expired 14CO2) is not constant throughout the day but is highest during the dark hours. Starvation is associated with accelerated protein catabolism and a gradual loss of periodicity. Infection increases the rate of catabolism still further and results in a complete loss of periodicity.
mesh_terms: D000818:Animals; D002940:Circadian Rhythm; D009124:Muscle Proteins / Q000378:metabolism; D011008:Pneumococcal Infections / Q000378:metabolism*; D011506:Proteins / Q000378:metabolism*; D051381:Rats; D013217:Starvation / Q000378:metabolism*
chemical_list: D009124:Muscle Proteins; D011506:Proteins