[The role of reduction of the heart rate in the favorable effect of the beta blockers on myocardial ischemia due to isoprenalin in patients with angina pectoris].
In the patient suffering from angina, the protective effect of oxprenolol in the isoprenaline test is demonstrated by the reduction of disappearance of ischemic-type electrocardiographic alterations and of angina and rhythm disturbances. In our study, these results were obtained in spite of neutralization of the negative chronotropic effect of the beta-blocker through the use of an endo-auricular pacemaker. This points indirectly to the role played by the contractile state of the myocard in catecholamine-induced modifications of the oxygen intake of cardiac muscle.
D000328:Adult; D000368:Aged; D000787:Angina Pectoris / Q000188:drug therapy*; D003327:Coronary Disease / Q000139:chemically induced*; D005260:Female; D006801:Humans; D007545:Isoproterenol / Q000009:adverse effects; D008297:Male; D008875:Middle Aged; D010096:Oxprenolol / Q000627:therapeutic use*; D010138:Pacemaker, Artificial; D013610:Tachycardia / Q000139:chemically induced
D010096:Oxprenolol; D007545:Isoproterenol
Le rôle du ralentissement de la fréquence cardiaque dans l'effet favorable des béta-bloquants sur l'ischémie du myocarde provoquée par l'isoprénaline chez l'angineux.