Effect of dopamine in stress ulcer of rats.
The effect of dopamine in stress-induced ulceration of stomach mucosa employing a hypoxia-immobilisation stress, was investigated in rats. Intravenous administration of small doses of dopamine (3 mug/kg body weight/min) significantly lowered the development of mucosa erosions. A bilious reflux which was observed after dopamine infusion but not in controls may be considered as a side effect of this agent.
D000818:Animals; D004298:Dopamine / Q000008:administration & dosage / Q000627:therapeutic use*; D007263:Infusions, Parenteral; D008297:Male; D051381:Rats; D013276:Stomach Ulcer / Q000209:etiology / Q000517:prevention & control*; D013312:Stress, Physiological / Q000150:complications*
D004298:Dopamine