Effects of corticosteroid hormone on the epiphyseal growth center of immature pregnant mice.
Immature pregnant mice treated with glucocorticoid hormone (triamcinolone hexacetonide) were killed 1 week following delivery. The epiphyseal growth plates of the humerus and their cellular constituents were analyzed quantitatively. It became evident that pregnancy per se evokes a marked suppressive effect upon young cartilage cells, thus interfering with the normal process of endochondral bone formation. Pregnant mice treated with glucocorticoid hormone experienced an even higher degree of chondrocytic derangement, however, to a lesser extent than chondroxytes of nonpregnant mice treated with the hormone. It therefore appears that pregnancy-induced elevation of systemic estrogens and progesterone provides some kind of a protection against the antianabolic activity of glucocorticoids upon chondrocytes.
D000305:Adrenal Cortex Hormones / Q000494:pharmacology*; D000818:Animals; D001835:Body Weight / Q000187:drug effects; D002356:Cartilage / Q000166:cytology / Q000254:growth & development; D002455:Cell Division / Q000187:drug effects; D004838:Epiphyses / Q000166:cytology / Q000187:drug effects* / Q000254:growth & development; D005260:Female; D006811:Humerus / Q000166:cytology / Q000254:growth & development; D051379:Mice; D011247:Pregnancy; D011270:Pregnancy, Animal; D014221:Triamcinolone / Q000494:pharmacology
D000305:Adrenal Cortex Hormones; D014221:Triamcinolone