Some aspects of the pharmacology of butibufen, a non-steroidal anti-inflammatory agent.
The anti-inflammatory, analgesic and antipyretic properties of butibufen, a non-steroidal compound, were assessed by a battery of standard tests. It activity as an anti-inflammatory agent was equivalent to ibuprofen and phenylbutazone. Butibufen was within the potency range of ibuprofen as an antipyretic and analgesic agent and greater than that of acetylsalicylic acid. The compound possesses the advantage of a low order to toxicity. Its ulcerogenicity was much lower than that of phenylbutazone. Therefore, butibufen appears to offer potential safety and efficacy in the treatment of rheumatic diseases.
D000085:Acetates / Q000037:antagonists & inhibitors; D000700:Analgesics; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology* / Q000633:toxicity; D001169:Arthritis, Experimental / Q000503:physiopathology; D001241:Aspirin / Q000494:pharmacology; D004487:Edema / Q000503:physiopathology; D006097:Granulation Tissue / Q000187:drug effects; D007052:Ibuprofen / Q000494:pharmacology; D007928:Lethal Dose 50; D051379:Mice; D010653:Phenylbutazone / Q000494:pharmacology; D010654:Phenylbutyrates / Q000494:pharmacology* / Q000633:toxicity; D051381:Rats; D011930:Reaction Time / Q000187:drug effects; D013276:Stomach Ulcer / Q000139:chemically induced
D000085:Acetates; D000700:Analgesics; D000893:Anti-Inflammatory Agents; D010654:Phenylbutyrates; D010653:Phenylbutazone; C012797:butibufen; D001241:Aspirin; D007052:Ibuprofen