[Protection of the mouse digestive tract from the toxic effect of cytosine-arabinoside].
Comparative experiments have demonstrated a qualitative difference of protective effects, observed in peroral application of 2'-desoxycytidine molecular solution and activated carbon suspension with 2'-desoxycytidine molecules adsorbed onto its particles with regard to the toxicity of intraperitoneal injections of cytosine arabinoside in female C57bl/6j mice. In contrast to 2'-deosyxycytidine molecular solution, which reduced all toxic manifestations and protected animals from death, the corpuscular form of the  protector only the toxic effect of the antimetabolite on the intestine without affecting other toxic manifestations, the inhibition of hemopoiesis in particular.
D000818:Animals; D003561:Cytarabine / Q000008:administration & dosage / Q000494:pharmacology*; D003841:Deoxycytidine / Q000008:administration & dosage / Q000494:pharmacology; D004064:Digestive System / Q000187:drug effects*; D004338:Drug Combinations; D004347:Drug Interactions; D005260:Female; D051379:Mice; D008810:Mice, Inbred C57BL; D013535:Suspensions; D013997:Time Factors
D004338:Drug Combinations; D013535:Suspensions; D003561:Cytarabine; D003841:Deoxycytidine
Zashchita pishchevaritel'nogo trakta mysheĭ ot toksicheskogo vliianiia tsitozin-arabinozida.