Regional variations in cell proliferation and matrix formation in the cartilaginous nasal septum of the rat. [3H]-Thymidine and [35S]-sulfate incorporation studies.
The anterior, middle and posterior regions of the cartilaginous nasal septum were studied using [3H]-thymidine and [35S]-sulfate incorporation. Varying intensity in both cell proliferation and matrix formation were found at different developmental stages. Taking the whole experimental period under consideration (from 0-21 days) the greatest proliferative activities were found in the anterior and posterior regions respectively, whereas the greatest activities in matrix formation were found in the middle and posterior regions (cpm [3H]-thymidine/DNA and cpm [35S]-sulfate/DNA). An increase in proliferation was followed shortly after by an increase in matrix formation.
D000818:Animals; D000831:Animals, Newborn; D001345:Autoradiography; D002807:Chondroitin / Q000031:analogs & derivatives*; D002809:Chondroitin Sulfates / Q000378:metabolism*; D004247:DNA / Q000378:metabolism*; D005260:Female; D008297:Male; D009300:Nasal Septum / Q000254:growth & development*; D051381:Rats; D012588:Scintillation Counting; D013462:Sulfur Radioisotopes; D013936:Thymidine / Q000378:metabolism; D014316:Tritium
D013462:Sulfur Radioisotopes; D014316:Tritium; D002807:Chondroitin; D002809:Chondroitin Sulfates; D004247:DNA; D013936:Thymidine