The effect of insulin on lung metabolism in the rat.
A new model has been established for the perfused in situ rat lung. During perfusion with glucose at 4 mmol/l, physiological concentrations of insulin (50 mu/l) caused an initial 1.5 fold increase in lactate production; the increase being sustained at 30% for the 4 h of perfusion. The observation that the lung responds to physiological concentrations of insulin could have important implications with respect to whole body carbohydrate metabolism.
D000818:Animals; D007328:Insulin / Q000494:pharmacology*; D007773:Lactates / Q000096:biosynthesis; D008168:Lung / Q000187:drug effects / Q000378:metabolism*; D008954:Models, Biological; D010477:Perfusion / Q000379:methods; D051381:Rats
D007328:Insulin; D007773:Lactates