Spironolactone: relationship between concentrations of dethioacetylated metabolite in human serum and milk.
The concentration of canrenone, a principal metabolite of spironolactone, was determined in human serum and milk. The milk to serum concentration ratios of this metabolite were 0.72 at 2 hr and 0.51 at 14.5 hr after ingestation of spironolactone. It was estimated that the maximum quantity of canrenone ingested daily by a human infant via its mother's milk would be approximately 0.2% of the daily dose of spironolactone given to the mother.
D000328:Adult; D002192:Canrenone / Q000032:analysis* / Q000097:blood; D005260:Female; D006801:Humans; D008895:Milk, Human / Q000737:chemistry*; D011245:Pregnadienes / Q000032:analysis*; D013148:Spironolactone / Q000097:blood; D013997:Time Factors
D011245:Pregnadienes; D013148:Spironolactone; D002192:Canrenone