[The renin-angiotensin-aldosterone system in hypertensive patients. II. Diagnosis of primary hyperaldosteronism].
Twenty patients suffering from primary hyperaldosteronism were studied. Sixteen had a single adenoma of the adrenal and four had bilateral hyperplasia affecting both adrenals. Cases of primary hyperaldosteronism due to a tumour were characterised by a higher degree of hypermineralocorticism than was seen in the patients with hyperplasia. Plasma aldosterone, after acute volaemic expansion, did not fall below 13 ng/100 ml in the adenoma patients whilst it was lower in the case of hyperplasia. Adrenal phlebography is a useful tool in preoperative diagnosis.
D000236:Adenoma; D000293:Adolescent; D000306:Adrenal Cortex Neoplasms / Q000175:diagnosis; D000308:Adrenocortical Hyperfunction / Q000175:diagnosis; D000328:Adult; D000450:Aldosterone / Q000097:blood*; D001794:Blood Pressure / Q000187:drug effects; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D006929:Hyperaldosteronism / Q000175:diagnosis*; D006973:Hypertension / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D011187:Posture; D011188:Potassium / Q000378:metabolism; D012083:Renin / Q000097:blood; D012964:Sodium / Q000378:metabolism; D012965:Sodium Chloride / Q000494:pharmacology; D013148:Spironolactone / Q000627:therapeutic use
D013148:Spironolactone; D012965:Sodium Chloride; D000450:Aldosterone; D012964:Sodium; D012083:Renin; D011188:Potassium
Le système rénine-angiotensine-aldostérone chez les sujets hypertendus. II. Le diagnostic de l'hyperaldostéronisme primaire.