Effect of chronic treatment with propranolol on blood pressure and cardiovascular reactivity in spontaneously hypertensive rats.
Young SHR were treated with propranolol (16 or 64 mg/kg per day) from 6 up to 14 weeks of age. Systolic blood pressure was significantly lower in SHR treated with propranolol (64 mg/kg) than in untreated SHR; no effect was seen in SHR treated with 16 mg/kg. The hemodynamic characteristics of the hindquarter vascular beds did not significantly differ between untreated and propranolol-treated SHR. Adult SHR were given propranolol (64 mg/kg per day) from 5 up to 8 months of age. Moderate reduction of systolic blood pressure was observed from 2 to 3 months of propranolol treatment. The cardiovascular pressor response to noradrenaline decreased in propranolol-treated SHR, while the decreased responsiveness was not found after pithing.
D000315:Adrenalectomy; D000367:Age Factors; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects*; D002490:Central Nervous System / Q000502:physiology; D005260:Female; D006339:Heart Rate / Q000187:drug effects; D006439:Hemodynamics / Q000187:drug effects*; D006614:Hindlimb / Q000098:blood supply; D006892:Hydroxydopamines / Q000494:pharmacology; D006973:Hypertension / Q000503:physiopathology*; D009538:Nicotine / Q000494:pharmacology; D009638:Norepinephrine / Q000494:pharmacology; D011433:Propranolol / Q000008:administration & dosage / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D012039:Regional Blood Flow / Q000187:drug effects; D013997:Time Factors; D014655:Vascular Resistance / Q000187:drug effects
D006892:Hydroxydopamines; D009538:Nicotine; D011433:Propranolol; D009638:Norepinephrine