The occurence of collagen type II in bronchogenic carcinoma.
It has been evidenced in a single case of bronchogenic carcinoma, that the proportion of collagen type II is increased in the diseased tissue. During the experimental work the collagenous stroma was isolated, subjected to cyanogen bromide cleavage and the relative proportion of individual types of collagen was judged according to the occurence of alpha1(I)CB3 and alpha1 (II)CB3 peptides. The nature of these peptides was proved by the chromatographic behavior during CM-cellulose chromatography, Ultrogel AcA 54 separation and by their amino acid composition.
D000596:Amino Acids / Q000032:analysis; D000818:Animals; D002266:Carboxymethylcellulose Sodium; D002283:Carcinoma, Bronchogenic / Q000378:metabolism*; D002845:Chromatography; D003094:Collagen / Q000302:isolation & purification / Q000378:metabolism*; D006801:Humans; D008175:Lung Neoplasms / Q000378:metabolism*; D051381:Rats; D012867:Skin / Q000378:metabolism
D000596:Amino Acids; D003094:Collagen; D002266:Carboxymethylcellulose Sodium