beta-Endorphin secretion of arginine vasopressin in vivo.
The effect of beta-endorphin upon plasma arg8-vasopressin release was studied in vivo in rabbits and in vitro in rat neural lobes. Following intravenous administration of 200 mug/kg synthetic beta-endorphin plasma AVP rose significantly by five minutes after injection and remained elevated for twenty-five minutes compared to controls. In contrast beta-endorphin had no significant effect on AVP release from isolated rat neural lobes in vitro. beta-Endorphin stimulates AVP secretion in vivo, but this is not due to a direct action upon the neural lobe.
D000818:Animals; D001127:Arginine Vasopressin / Q000097:blood / Q000378:metabolism*; D004723:Endorphins / Q000494:pharmacology*; D066298:In Vitro Techniques; D010904:Pituitary Gland, Posterior / Q000187:drug effects / Q000378:metabolism*; D011817:Rabbits; D051381:Rats; D014667:Vasopressins / Q000031:analogs & derivatives*
D004723:Endorphins; D014667:Vasopressins; D001127:Arginine Vasopressin