Electron microscopic effects of thallium poisoning on the rat hypothalamus and hippocampus: biochemica changes in the cerebrum.
Rats were given thallous acetate (5 mg elemental thallium/kg body weight) IP daily for 7 days and prepared for electron microscopy (perfusion-fixation) and for biochemical study. Increased incidence of Golgi zones and electron-dense bodies were observed in the anterior hypothalamus and hippocampus. Sequestrated axons were seen in the hypothalamus. Depletion of succinic dehydrogenase and guanine deaminase occurred in the cerebrum.
D000818:Animals; D002540:Cerebral Cortex / Q000187:drug effects / Q000201:enzymology; D004721:Endoplasmic Reticulum / Q000648:ultrastructure; D006056:Golgi Apparatus / Q000648:ultrastructure; D006148:Guanine Deaminase / Q000032:analysis; D006624:Hippocampus / Q000187:drug effects / Q000648:ultrastructure*; D007031:Hypothalamus / Q000648:ultrastructure*; D007032:Hypothalamus, Anterior / Q000187:drug effects / Q000648:ultrastructure*; D008297:Male; D008928:Mitochondria / Q000648:ultrastructure; D051381:Rats; D013385:Succinate Dehydrogenase / Q000032:analysis; D013572:Synaptic Vesicles / Q000648:ultrastructure; D013793:Thallium / Q000506:poisoning*
D013793:Thallium; D013385:Succinate Dehydrogenase; D006148:Guanine Deaminase