The effect of ascorbic acid supplementation on some parameters of the human immunological defence system.
We have investigated the effect of ascorbic acid (vitamin C) supplementation on some parameters of the human immune defence system in a group of 25 healthy, male university students. The subjects ingested 1 g ascorbic acid per day for a period of 75 days. Serum levels of IgA, IgG, IgM, C-3 complement component, cortisol and transcortin were measured before and after the ascorbic acid course. Corresponding measurements were performed on a control group of 20 healthy, male university students receiving no extra-dietary vitamin C. Our results showed that ascorbic acid supplementation caused a statistically significant increase in the serum levels of IgA, IgM and C-3 complement. Our study does not permit of conclusions regarding the mechanisms of action of ascorbic acid.
D000293:Adolescent; D000328:Adult; D001205:Ascorbic Acid / Q000494:pharmacology*; D003176:Complement C3 / Q000032:analysis; D006801:Humans; D006854:Hydrocortisone / Q000097:blood*; D007070:Immunoglobulin A / Q000032:analysis; D007074:Immunoglobulin G / Q000032:analysis; D007075:Immunoglobulin M / Q000032:analysis; D007136:Immunoglobulins / Q000032:analysis; D008297:Male; D014156:Transcortin / Q000097:blood*
D003176:Complement C3; D007070:Immunoglobulin A; D007074:Immunoglobulin G; D007075:Immunoglobulin M; D007136:Immunoglobulins; D014156:Transcortin; D001205:Ascorbic Acid; D006854:Hydrocortisone