title: [Clinical studies with minocycline intravenous instillation. Chemotherapy in patients with renal impairment (author's transl)].
abstract: In the present studies, we had an opportunity to review the effects of minocycline intravenous instillation for the treatment of moderate disorder of renal functions. No accumulation of minocycline was observed in the repeated administration of this drug instilled intravenously up to 7 days in the patients with moderate disorder of the renal functions. Also, no particular abnormality was observed in the tests of the liver, kidney and hematology. For patients with moderate Ccr 30 approximately 60 ml/min, as entered into the present study, the usual dosage of minocycline intravenous instillation for less than 7 days would not cause adverse reaction on renal functions.
mesh_terms: D000328:Adult; D000368:Aged; D000818:Animals; D004285:Dogs; D005260:Female; D006801:Humans; D007275:Injections, Intravenous; D007674:Kidney Diseases / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D008911:Minocycline / Q000008:administration & dosage* / Q000009:adverse effects / Q000097:blood; D013754:Tetracyclines / Q000008:administration & dosage*
chemical_list: D013754:Tetracyclines; D008911:Minocycline