Fortimicins A and B, new aminoglycoside antibiotics. I. Producing organism, fermentation and biological properties of fortimicins.
A culture of Micromonospora species MK-70 was found to produce two new antibiotics, fortimicins A and B. Antibacterial and paper chromatographic data on an eluate from IRC-50 treatment of fermentation beers indicated that fortimicins A and B are new antibiotics with broad-spectrum, basic and water-soluble properties. Fortimicin A exhibited potent, unique, broad-spectrum antibacterial activity against Gram-positive and negative bacteria both in vitro and in vivo, while fortimicin B was only weakly active.
D000617:Aminoglycosides / Q000096:biosynthesis* / Q000494:pharmacology; D000818:Animals; D000900:Anti-Bacterial Agents / Q000096:biosynthesis* / Q000494:pharmacology; D001419:Bacteria / Q000187:drug effects; D002244:Carbon / Q000378:metabolism; D003470:Culture Media; D005285:Fermentation / Q000187:drug effects; D008670:Metals / Q000494:pharmacology; D051379:Mice; D008847:Micromonospora / Q000378:metabolism*; D009584:Nitrogen / Q000378:metabolism; D013997:Time Factors
D000617:Aminoglycosides; D000900:Anti-Bacterial Agents; D003470:Culture Media; D008670:Metals; D002244:Carbon; D009584:Nitrogen