title: Electron-microscopic study of collagenous fibers of cultures of bone marrow from healthy children.
abstract: Bundles of collagenous fibers have been detected by means of the electron microscope in the intercellular space among hematogenic and stromal cells of 9- and 13-day cultures of bone marrow of two 6-year-old healthy children in course of formation of fibroblast-like cells. Detection of the latter in the cultures during growth gives rise to the suggestion that collagen-producing cells (true fibroblasts) may be formed in vitro. The data obtained are discussed in connection with the question of fibroblast-like cells transformed in vitro to true fibroblasts.
mesh_terms: D001853:Bone Marrow / Q000648:ultrastructure; D001854:Bone Marrow Cells; D002478:Cells, Cultured; D002648:Child; D003094:Collagen; D003238:Connective Tissue / Q000648:ultrastructure*; D003239:Connective Tissue Cells; D004547:Elastic Tissue / Q000166:cytology / Q000648:ultrastructure; D005347:Fibroblasts / Q000648:ultrastructure; D006801:Humans
chemical_list: D003094:Collagen