title: Comparative pharmacology of cefaclor and cephalexin.
abstract: Two cephalosporin antibiotics, cefaclor and cephalexin, were administered orally to healthy, adult male volunteers for comparison of their pharmacological properties. In doses of 250 mg orally, cefaclor produced a peak serum concentration of 6.01 +/- 0.55 (standard deviation [SD]) mug/ml compared with 9.43 +/- 2.36 mug/ml for cephalexin (P < 0.01). The half-lives were 0.58 +/- 0.07 (SD) h and 0.80 +/- 0.12 (SD) h, and elimination constants were 1.22 +/- 0.15 and 0.88 +/- 0.13 h(-1) for cefaclor and cephalexin, respectively (P < 0.001). Neither drug showed accumulation over the dosing period, and both were well tolerated.
mesh_terms: D000328:Adult; D002506:Cephalexin / Q000009:adverse effects / Q000378:metabolism*; D002511:Cephalosporins / Q000009:adverse effects / Q000378:metabolism*; D006207:Half-Life; D006801:Humans; D007408:Intestinal Absorption; D008297:Male; D013997:Time Factors
chemical_list: D002511:Cephalosporins; D002506:Cephalexin