Isolation and characterization of a novel trisialoganglioside, GT1a, from human brain.
A novel trisialoganglioside has been isolated from normal adult human brain in a yield of 0.6% of the total gangkioside. By graded neuraminidase treatment, mild acid hydrolysis and periodate oxidation analysis, the ganglioside was identified as GT1a having the following structure: NeuAc(alpha, 2-8)NeuAc(alpha, 2-3)Gal(beta, 1-3)GalNAc(beta, 1-4) [NeuAc(alpha, 2-3)]Gal(beta, 1-4)Glc(1-1)ceramide.
D001923:Brain Chemistry; D005732:Gangliosides / Q000302:isolation & purification*; D006801:Humans; D008297:Male; D008875:Middle Aged; D012794:Sialic Acids / Q000032:analysis*
D005732:Gangliosides; D012794:Sialic Acids