title: The frequency and distribution of sister chromatid exchanges in human chromosomes.
abstract: The distribution of sister chromatid exchanges (SCEs) both between and within chromosomes was studied in cultured human lymphocytes using the BRDU-Giemsa technique. In general, the distribution of SCEs between chromosomes was a function of chromosome length. However, chromosomes of the B group had more exchanges than expected on this basis, while the E, F, and G groups had less than expected. Analysis of cells showing both G-banding and sister chromatid differential staining indicates that the distribution of exchanges within the chromosomes is non-random and possible reasons for the observed distribution pattern are discussed.
mesh_terms: D002842:Chromatids; D002869:Chromosome Aberrations; D002877:Chromosomes, Human; D002902:Chromosomes, Human, 16-18; D002903:Chromosomes, Human, 19-20; D002904:Chromosomes, Human, 21-22 and Y; D002905:Chromosomes, Human, 4-5; D005260:Female; D006801:Humans; D008214:Lymphocytes; D008297:Male