title: N-(4-Acetamidophenyl)-anti-tricyclo [4.2.2.025-] deca-3, 9-diene-7, 8-endodicarboximide (1)--a chemically novel anticonvulsant.
abstract: The present report describes the activity of a dicarboximide in various test procedures in mice believed to define the therapeutic efficacy to compounds as antiepileptic agents. Comparative studies with diphenylhydantoin, phenobarbital and trimethadione have shown the profile of activity, potency and duration of action of the dicarboximide to closely resemble diphenylhydantoin. This dicarboximide is chemically novel in relation to presently employed therapeutic agents and could offer promise as a new class of agents with potential value in the treatment of convulsive disorders.
mesh_terms: D000818:Animals; D000927:Anticonvulsants; D001952:Bridged-Ring Compounds / Q000494:pharmacology; D004597:Electroshock; D005260:Female; D007094:Imides / Q000494:pharmacology*; D051379:Mice; D008815:Mice, Inbred Strains; D009048:Motor Skills / Q000187:drug effects; D010433:Pentylenetetrazole / Q000037:antagonists & inhibitors; D012640:Seizures / Q000209:etiology / Q000503:physiopathology
chemical_list: D000927:Anticonvulsants; D001952:Bridged-Ring Compounds; D007094:Imides; D010433:Pentylenetetrazole