Electron-microscopic study of collagenous fibers of cultures of bone marrow from healthy children.
Bundles of collagenous fibers have been detected by means of the electron microscope in the intercellular space among hematogenic and stromal cells of 9- and 13-day cultures of bone marrow of two 6-year-old healthy children in course of formation of fibroblast-like cells. Detection of the latter in the cultures during growth gives rise to the suggestion that collagen-producing cells (true fibroblasts) may be formed in vitro. The data obtained are discussed in connection with the question of fibroblast-like cells transformed in vitro to true fibroblasts.
D001853:Bone Marrow / Q000648:ultrastructure; D001854:Bone Marrow Cells; D002478:Cells, Cultured; D002648:Child; D003094:Collagen; D003238:Connective Tissue / Q000648:ultrastructure*; D003239:Connective Tissue Cells; D004547:Elastic Tissue / Q000166:cytology / Q000648:ultrastructure; D005347:Fibroblasts / Q000648:ultrastructure; D006801:Humans
D003094:Collagen