title: Primary malignant tumors of the thyroid gland: a clinicopathologic study of 254 cases.
abstract: Of 254 primary malignant tumors of the thyroid gland diagnosed in the pathology department of the University of Cape Town, 212 (83.5%) were differentiated carcinomas. In this differentiated group, tumors composed exclusively of papillary structures exhibited the most favorable prognosis; local recurrences and/or spread were noted in tumors with a mixed papillary and follicular pattern and, more commonly association with 21 tumors (8.3%) but an associated multinodular goitre was found in only nine patients (3.5%). In addition to the well-known preponderance of thyroid carcinoma in women, a majority of lesions occurred in white patients in this series despite a higher hospital admission rate for coloreds (mulattos).
mesh_terms: D000230:Adenocarcinoma / Q000473:pathology; D000328:Adult; D000367:Age Factors; D000368:Aged; D002291:Carcinoma, Papillary / Q000473:pathology; D002648:Child; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D009362:Neoplasm Metastasis; D009364:Neoplasm Recurrence, Local; D011379:Prognosis; D044469:Racial Groups; D012737:Sex Factors; D013019:South Africa; D013964:Thyroid Neoplasms / Q000453:epidemiology / Q000473:pathology*