The influence of synthetic corticoids on the isolated vas deferens of the rat.
The influence of corticosteroids on the tone of isolated smooth muscle (vas deferens of the rat) is reported. Corticoids alone are without effect on the muscle tone, but they potentiate the constrictor effect of catecholamines. Fluorinated synthetic steroids exhibit a more pronounced effect than non-halogenated ones.
D000287:Administration, Topical; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology*; D003907:Dexamethasone / Q000494:pharmacology; D005447:Fluocinonide / Q000494:pharmacology; D005938:Glucocorticoids; D006854:Hydrocortisone; D008297:Male; D009130:Muscle, Smooth / Q000187:drug effects; D011239:Prednisolone; D051381:Rats; D014649:Vas Deferens / Q000187:drug effects*
D000893:Anti-Inflammatory Agents; D005938:Glucocorticoids; D005447:Fluocinonide; D003907:Dexamethasone; D011239:Prednisolone; D006854:Hydrocortisone