[Determination of intra-uterine oxygen tension in rats after biovariectomy between the 7th and 12th day of gestation].
In pregnant female rat, oxygen tension was measured in vivo with an oxygen microelectrode and the following statistically significant data (Student's test) were obtained: -- not significant variability in four groups of six control rats; -- highly significant decrease of oxygen tension twenty-four hours after biovariectomy in four groups of six operated rats; -- in twelve operated and treated by substitutive hormonotherapy rats, pO2 was at the same level than in control rats; -- in eighteen operated rats, the oxygen tension measured after embryonic death was identical to control rats. These experiments clearly demonstrate twenty four hours after biovariectomy a decreased oxygen tension. Simultaneously to this decrease, a diminution of uterine blood flow takes place. This pO2 diminution should be dependent on decrease of ovarian hormones since the substitutive hormonotherapy prevents its appearance. A good explanation of this phenomenon is the high requirement of hypoxic embryo for oxygen; moreover after the embryonic death, the intra-uterine pO2 increases.
D000818:Animals; D002369:Castration; D005260:Female; D010100:Oxygen / Q000097:blood*; D010313:Partial Pressure; D011247:Pregnancy; D011270:Pregnancy, Animal; D051381:Rats; D014599:Uterus / Q000098:blood supply*
D010100:Oxygen
Mesure de la tension intra-utérine d'oxygène chez la ratte après biovariectomie entre le 7e et 12e jour de la gestation.