Normal response to pilocarpine and phenylephrine.
Fifty-eight eyes from 58 patients in which there was no evidence of glaucoma were provoked with pilocarpine and phenylephrine drops. The result was a significant reduction in intraocular pressure and a significant increase in outflow facility. The 58 eyes were randomised and 19 submitted to a 'dummy' provocative test. There was no significant change in either pressure or outflow facility. The effect of the pilocarpine/phenylephrine provocative test in normal eyes is to produce a response that is the opposite of a positive provocative test in eyes at risk of developing closed-angle glaucoma.
D004338:Drug Combinations; D005901:Glaucoma / Q000175:diagnosis; D006801:Humans; D007429:Intraocular Pressure / Q000187:drug effects*; D010656:Phenylephrine / Q000494:pharmacology*; D010862:Pilocarpine / Q000494:pharmacology*
D004338:Drug Combinations; D010862:Pilocarpine; D010656:Phenylephrine