The effect of zinc on anaphylaxis in vivo in the guinea-pig.
The protective effects of pretreatment with zinc sulphate aerosols against bronchoconstriction induced by egg albumen or histamine aerosols were assessed in sensitized or non-sensitized guinea-pigs respectively. Pretreatment with an adequate concentration of zinc sulphate aerosol significantly prolonged the time of onset of bronchoconstriction in sensitized guinea-pigs challenged with egg albumen, but did not appreciably alter the onset time of histamine-induced bronchoconstriction in non-sensitized animals. These findings suggest that zinc aerosols may be of prophylactic value against bronchoconstriction of allergic origin.
D000336:Aerosols; D000707:Anaphylaxis / Q000503:physiopathology*; D000818:Animals; D001986:Bronchial Spasm / Q000517:prevention & control*; D005260:Female; D006168:Guinea Pigs; D006632:Histamine / Q000494:pharmacology; D008297:Male; D010047:Ovalbumin / Q000276:immunology; D015032:Zinc / Q000008:administration & dosage / Q000494:pharmacology*
D000336:Aerosols; D006632:Histamine; D010047:Ovalbumin; D015032:Zinc