[Immunostimulation of the growth of a syngeneic sarcoma primarily induced in mice by simian adenovirus SA7(C8)].
Transplantation of splenic cells from CBA mice bearing primary sarcoma SA7(C8) together with autologous sarcoma cells (in the ratio 1 : 1 and 10 : 1) into syngeneic recipients, irradiated with 600 rad, resulted in a marked decrease of the latent period of tumor development. Syngeneic splenocytes of normal mice would enhance the tumor growth with the ratio 10 : 1. Preliminary treatment of tumor-bearing and normal mice with hydrocortisone in the dosage of 6 mg per 100 g of weight fails to reduce the capacity of splenic cells to induce immunostimulation of tumor growth.
D000256:Adenoviridae / Q000472:pathogenicity*; D000261:Adenoviruses, Simian / Q000472:pathogenicity*; D000818:Animals; D003601:Cytotoxicity Tests, Immunologic; D005260:Female; D006854:Hydrocortisone / Q000494:pharmacology; D007111:Immunity, Cellular / Q000187:drug effects / Q000528:radiation effects; D008214:Lymphocytes / Q000276:immunology; D051379:Mice; D008808:Mice, Inbred CBA; D009368:Neoplasm Transplantation; D012513:Sarcoma, Experimental / Q000276:immunology*; D013154:Spleen / Q000166:cytology / Q000276:immunology; D013997:Time Factors; D014185:Transplantation, Isogeneic
D006854:Hydrocortisone
Immunostimuliatsiia rosta singennoĭ sarkomy, pervichno indutsirovannoĭ u mysheĭ adenovirusom obez'ian SA7(C8).