Surface tension lowering and dissolution rate of hydrocortisone from solid solutions of selected n-acyl esters of cholesterol.
The dissolution of hydrocortisone into simulated intestinal fluid from lipid delivery systems followed second-order kinetics. As the ratio of hydrocortisone to lipid was increased from 1:1 to 1:6, the dissolution rate decreased. Solvent deposition of solid solutions of hydrocortisone and lipid on lactose resulted in the enhancement of the dissolution rate. For the 1:1 hydrocortisone-lipid solid solutions, the rank order of the dissolution rate was hydrocortisone-cholesteryl stearate, hydrocortisone, hydrocortisone-cholesterol, hydrocortisone-cholesteryl acetate, hydrocortisone-cholesteryl palmitate, hydrocortisone-cholesteryl n-butyrate, hydrocortisone-cholesteryl laurate, and hydrocortisone-cholesteryl n-decylate. A direct correlation was found between the dissolution rate of hydrocortisone and the surface tension lowering of simulated intestinal fluid by the corticoid and various lipids.
D055598:Chemical Phenomena; D002621:Chemistry; D002788:Cholesterol Esters; D006854:Hydrocortisone / Q000032:analysis; D007419:Intestinal Secretions; D007700:Kinetics; D008055:Lipids; D012995:Solubility; D012996:Solutions; D013056:Spectrophotometry, Ultraviolet; D013500:Surface Tension
D002788:Cholesterol Esters; D008055:Lipids; D012996:Solutions; D006854:Hydrocortisone