Chemical mutagenesis: an emerging issue for public health.
Chemical mutagens are recognized as prevalent in the environment and a potential threat to the health of future generations. This paper presents an overview of chemical mutagenesis as an issue for public health. Several problems in the determination of risk to human populations are discussed, including difficulties of extrapolating scientific data to humans, the latency period between exposure and recognizable genetic damage, and the large number of chemicals which must be tested. Test systems are described. Possibilities of control through federal regulation are discussed.
D000014:Abnormalities, Drug-Induced / Q000235:genetics; D000818:Animals; D002273:Carcinogens / Q000032:analysis; D004353:Drug Evaluation, Preclinical; D004781:Environmental Exposure; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D007880:Legislation, Drug; D008452:Maximum Allowable Concentration; D008722:Methods; D009153:Mutagens / Q000009:adverse effects* / Q000032:analysis; D009154:Mutation / Q000187:drug effects; D009784:Occupational Diseases / Q000235:genetics; D011247:Pregnancy; D011634:Public Health; D012306:Risk
D002273:Carcinogens; D009153:Mutagens