title: The selective induction of cellular damage within neoplasia in situ; a putative role for sympathomimetic agents.
abstract: Cancerous cells can be selectively injured within a host by various means. The effects generally appear to be manifested indirectly, and are consistent with the concept that uptake from the plasma of non-esterified fatty acids (NEFAs) by malignant tissue leads to an increase in uncoupling of oxidative phosphorylation. Certain lipolytic agents are already known to cause selective damage to cancerous growths in situ. The employment of appropriate sympathomimetic agents to accentuate the nocturnal rise in plasma NEFA concentrations may permit the management and control of a variety of human neoplasia.
mesh_terms: D005230:Fatty Acids, Nonesterified / Q000097:blood; D008053:Lipid Mobilization / Q000187:drug effects; D009369:Neoplasms / Q000188:drug therapy* / Q000378:metabolism; D010085:Oxidative Phosphorylation / Q000187:drug effects; D013566:Sympathomimetics / Q000494:pharmacology / Q000627:therapeutic use*
chemical_list: D005230:Fatty Acids, Nonesterified; D013566:Sympathomimetics