Effect of beta-endorphin on striatal dopamine metabolism.
Acute intraventricular administration of human beta-endorphin increased 3,4-dihydroxyphenylacetic acid (DOPAC) and homovanillic acid (HVA) concentrations in rat striatum at a time when the catatonic effect was also present. This effect of beta-endorphin is compatible with increased striatal dopamine turnover and is similar to the effect noted previously with morphine administration.
D015102:3,4-Dihydroxyphenylacetic Acid / Q000378:metabolism; D000818:Animals; D003342:Corpus Striatum / Q000187:drug effects / Q000378:metabolism*; D004298:Dopamine / Q000378:metabolism*; D004723:Endorphins / Q000494:pharmacology*; D006719:Homovanillic Acid / Q000378:metabolism; D008297:Male; D051381:Rats; D013997:Time Factors
D004723:Endorphins; D015102:3,4-Dihydroxyphenylacetic Acid; D004298:Dopamine; D006719:Homovanillic Acid