title: Experimental extracranial-intracranial anastomosis.
abstract: A new experimental model for the study of extracranial-intracranial anastomosis has been developed. Canine external ethmoidal arteries have been anastomosed to the middle cerebral arteries. A 100% patency rate has been achieved ten days after operation. The surgical techniques are described. Using this model, we studied the changes of cortical intraarterial pressure and tissue O2 tension under a variety of conditions. From the results of this experiment, it is concluded that the restoration of the cortical intra-arterial pressure may be expected after anastomosis, that tissue O2 tension value depends upon restoration of the cortical intra-arterial pressure in the acute stage, and that O2 and CO2 inhalations have little effect on the brain ten days after middle cerebral arterial occlusion in spite of recovery of intra-arterial pressure with anastomosis. The experimental results suggest that the restoration of the intra-arterial pressure after anastomosis may be of no use in supplying oxygen to ischemic cortex in the chronic stage because of dysfunction of the cortical microvasculature.
mesh_terms: D000818:Animals; D001158:Arteries / Q000502:physiology / Q000601:surgery; D001794:Blood Pressure; D001921:Brain / Q000378:metabolism; D002536:Cerebral Arteries / Q000502:physiology / Q000601:surgery*; D004285:Dogs; D005004:Ethmoid Bone / Q000098:blood supply; D010100:Oxygen / Q000008:administration & dosage / Q000378:metabolism
chemical_list: D010100:Oxygen