Serum somatomedin peptides measured by somatomedin A radioreceptor assay in chronic liver disease.
The levels of serum somatomedin peptides were determined with a somatomedin A radioreceptor assay utilizing human placental membranes. Low levels were found in 25 patients with liver cirrhosis and 28 patients with chronic hepatitis with the mean of 0.47 +/- 0.05 and 0.60 +/- 0.04 U/ml, respectively. There was a positive correlation between somatomedin A on one hand and serum albumin, cholinesterase, total cholesterol and thrombotest on the other. There was a negative correlation between somatomedin A and the indocyanine green retention test. These findings confirm earlier results obtained with bioassay.
D000328:Adult; D000368:Aged; D002784:Cholesterol / Q000097:blood; D002802:Cholinesterases / Q000097:blood; D005260:Female; D006505:Hepatitis / Q000097:blood*; D006801:Humans; D008103:Liver Cirrhosis / Q000097:blood*; D008297:Male; D008875:Middle Aged; D011869:Radioligand Assay; D012709:Serum Albumin; D013002:Somatomedins / Q000097:blood*
D012709:Serum Albumin; D013002:Somatomedins; D002784:Cholesterol; D002802:Cholinesterases