Pharmacokinetics of bendroflumethiazide.
Bendroflumethiazide (bft), 10 mg, was administered orally to 9 healthy volunteers. The concentrations of the diuretic in plasma and urine were determined by gas-liquid chromatography (GLC). Peak plasma levels (86 +/- 18 ng/ml) of bft were reached at 2 +/- 0.4 hr. The concentration declined with a mean t1/2 of 3.0 hr. The apparent volume of distribution averaged 1.48 L/kg. The major part of the drug was eliminated via nonrenal mechanisms, the nonrenal clearance being estimated to 269 +/- 77 ml/min and renal clearance to 105 +/- 24 ml/min. Urinary recovery of the thiazide averaged 30%.
D000293:Adolescent; D000328:Adult; D001539:Bendroflumethiazide / Q000378:metabolism* / Q000494:pharmacology; D002118:Calcium / Q000652:urine; D002849:Chromatography, Gas; D004231:Diuresis / Q000187:drug effects; D005260:Female; D006801:Humans; D007700:Kinetics; D008274:Magnesium / Q000652:urine; D008297:Male; D009318:Natriuresis / Q000187:drug effects; D011188:Potassium / Q000652:urine; D013997:Time Factors
D001539:Bendroflumethiazide; D008274:Magnesium; D011188:Potassium; D002118:Calcium