Effect of LATS, TSH and cholera toxin on the thyroid gland in nude mice.
Three thyroid stimulators; LATS, TSH, and cholera toxin, have been tested by bioassay using congenitally athymic homozygous mice (nu/nu), nude mice and control littermates (nu/+) possessing normal thymic function. nu/+ Animals showed a response to LATS similarly to normal white mice of the ddN strain. The assay response to LATS in nu/nu animals was about half that in normal mice. TSH also showed a less stimulating action in nude mice. Cholera toxin made a long acting response similarly to LATS. The response to cholera toxin in nude mice was about half that of normal control mice. The thyroid of nude mice has a receptor for LATS-immunoglobulin, TSH or cholera toxin, which is similar to that of normal mice.
D000818:Animals; D001681:Biological Assay; D002772:Cholera Toxin / Q000097:blood / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D005260:Female; D008135:Long-Acting Thyroid Stimulator / Q000097:blood / Q000494:pharmacology*; D051379:Mice; D008819:Mice, Nude; D013961:Thyroid Gland / Q000187:drug effects*; D013972:Thyrotropin / Q000097:blood / Q000494:pharmacology*
D013972:Thyrotropin; D002772:Cholera Toxin; D008135:Long-Acting Thyroid Stimulator