Role and mechanism of peripheral fatty acid mobilization in 2-mercaptoethanol-induced fatty liver.
2-Mercaptoethanol-induced fatty liver involves an increased free fatty acid mobilization which is primarily due to an inhibition of free fatty acid reesterification in adipose tissue. Furthermore, increased free fatty acid mobilization as well as fatty liver induction are not induced by 2-mercaptoethanol per se but result most probably from 2-mercaptoacetate through oxidation of 2-mercaptoethanol.
D000255:Adenosine Triphosphate / Q000378:metabolism; D000273:Adipose Tissue / Q000378:metabolism; D000818:Animals; D005230:Fatty Acids, Nonesterified / Q000378:metabolism*; D005234:Fatty Liver / Q000139:chemically induced / Q000378:metabolism*; D005260:Female; D008053:Lipid Mobilization / Q000187:drug effects*; D008099:Liver / Q000187:drug effects / Q000378:metabolism; D008623:Mercaptoethanol / Q000494:pharmacology*; D011720:Pyrazoles / Q000494:pharmacology; D051381:Rats; D014280:Triglycerides / Q000378:metabolism
D005230:Fatty Acids, Nonesterified; D011720:Pyrazoles; D014280:Triglycerides; D008623:Mercaptoethanol; D000255:Adenosine Triphosphate