title: [Studies of the chronic toxicity of mold pectinase].
abstract: Studied was the action of mould pectinase produced in this country, using Asp. niger. Rats and guinea pigs were subject to the testing through continuous oral treatment. The preparation was mixed with feed at 0.1 and 0.2 ratio percents (1000 and 2000 ppm)--with the rats for a period of 90 days, and with the guinea pigs--in the course of 180 days. It was found that the enzyme preparation stimulates the growth (more strongly expressed in rats), showing no adverse effect on the appetite and behaviour as well as on the tested clinical and biochemical indices of the blood and urine and the structure and development of viscera and the reproductive capacity of the test animals. The positive effect on the growth of animals is explained by the better utilization of the nutrient components of the ration, and the harmlessness of the preparation--by its weak resorption in the digestive tract (resorption index 13) and the fact that it is not able to attack animal tissues having no pectin substances.
mesh_terms: D000284:Administration, Oral; D000818:Animals; D001066:Appetite / Q000187:drug effects; D001230:Aspergillus / Q000201:enzymology*; D001234:Aspergillus niger / Q000201:enzymology*; D004305:Dose-Response Relationship, Drug; D005260:Female; D006026:Glycoside Hydrolases / Q000633:toxicity*; D006128:Growth / Q000187:drug effects; D006168:Guinea Pigs; D008297:Male; D011096:Polygalacturonase / Q000633:toxicity*; D011247:Pregnancy; D051381:Rats; D013997:Time Factors
chemical_list: D006026:Glycoside Hydrolases; D011096:Polygalacturonase
vernacular_title: Prouchvaniia vurkhu khronichnata toksichnost na plesennata perktinaza.