[Immunogenic activity of cultural antirabies vaccine inactivated by gamma-rays].
Experimental lyophilized tissue culture rabies vaccine inactivated with gamma-rays was prepared from the Vnukovo-32 strain and showed a sufficiently high immunogenic activity. Complete inactivation of the virus and the immunogenic potency of the vaccine depended upon the dose of irradiation and temperature during irradiation. The virus lost infectivity at 18 degrees C when irradiated with 2.6 X 10(6) r and at --70 degrees C with 4.55 X 10(6) r. However, the immunogenic potency of the vaccine inactivated at minus temperature without thawing was significantly higher.
D000818:Animals; D000956:Antigens, Viral / Q000528:radiation effects; D004307:Dose-Response Relationship, Radiation; D005720:Gamma Rays; D051379:Mice; D011818:Rabies / Q000517:prevention & control; D011819:Rabies Vaccines / Q000528:radiation effects*; D011820:Rabies virus / Q000472:pathogenicity / Q000528:radiation effects; D013696:Temperature; D014611:Vaccination
D000956:Antigens, Viral; D011819:Rabies Vaccines
Immunogennaia aktivnost' kul'tural'noĭ antirabicheskoĭ vaktsiny, inaktivirovannoĭ gamma-luchami.