Destruction of joint homografts. An experimental study.
The host synovium undergoes a striking transformation at about 26 weeks after joint homografting. Histologically the synovium invaded and destroyed the graft with which it came in contact, becoming markedly hypercellular; the infiltrate consisted mainly of plasma cells and lymphocytes. The synovium at this stage closely resembled a rheumatoid pannus. The cartilage in contact with this invasive synovium lost its staining qualities, failed to take up S-35, and was gradually destroyed. The mechanism causing this transformation remains unclear. It is postulated that these changes could be due to an inflammatory or immune response.
D000818:Animals; D002356:Cartilage / Q000473:pathology; D004285:Dogs; D006084:Graft Rejection; D007719:Knee Joint / Q000473:pathology / Q000637:transplantation*; D008214:Lymphocytes / Q000276:immunology; D010950:Plasma Cells / Q000276:immunology; D013583:Synovial Membrane / Q000276:immunology; D014184:Transplantation, Homologous