Biphasic effects of m-chlorophenyl-piperazine on 3,4-dihydroxyphenylacetic acid concentration in rat brain.
m-Chlorophenyl-piperazine dihydrochloride injected i.p. into rats caused a rapid increase and a subsequent decrease in whole brain concentration of 3,4-dihydroxyphenylacetic acid (DOPAC), a metabolite of dopamine. The increase in DOPAC at 30 min and the decrease at 3 hrs were dose-related and occurred after doses as low as 5 mg/kg of m-chlorophenyl-piperazine dihydrochloride.
D015102:3,4-Dihydroxyphenylacetic Acid / Q000032:analysis*; D000818:Animals; D001923:Brain Chemistry / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D008297:Male; D010648:Phenylacetates / Q000032:analysis*; D010879:Piperazines / Q000494:pharmacology*; D051381:Rats; D013997:Time Factors
D010648:Phenylacetates; D010879:Piperazines; D015102:3,4-Dihydroxyphenylacetic Acid