Construction of a DBA/2.Fv-2r congenic strain. Apparent lethality of the homozygous Fv-2r genotype: brief communication.
From the (C57BL/6 X DBA/2)F1 cross, 13 serial backcrosses to the DBA/2 parental mouse strain were bred with selection by progeny testing in each generation for the Fv-2s/Fv-2r heterozygous genotype. Intercrossing heterozygotes of the 13th backcross generation produced no Fv-2r/Fv-2r homozygotes. Homozygosity for the Fv-2r allele thus appeared to be lethal on a DBA/2 background and in the absence of protector gene(s) of the C57BL strain.
D000818:Animals; D005260:Female; D005622:Friend murine leukemia virus / Q000235:genetics*; D005804:Genes, Lethal; D006720:Homozygote; D007178:Inbreeding; D007942:Leukemia, Experimental / Q000235:genetics* / Q000382:microbiology; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D008811:Mice, Inbred DBA / Q000235:genetics*; D013154:Spleen / Q000382:microbiology; D013489:Suppression, Genetic; D014412:Tumor Virus Infections / Q000235:genetics* / Q000382:microbiology