title: Effects of furosemide on glomerular filtration rate and clearance of practolol, digoxin, cephaloridine, and gentamicin.
abstract: Furosemide was shown to decrease inulin clearance in 20 of 27 normal subjects. The depression in inulin clearance occurred in both water-loaded and non-water-loaded subjects. The renal clearance of practolol, but not digoxin, was reduced when furosemide was given. The average total plasma clearances of gentamicin and of cephaloridine over a 6-hr period were decreased after furosemide. The reduced clearances of the antibiotics were associated with higher plasma levels, the increase in antibiotic concentration being as much as 100% at 1 hr after an intravenous bolus injection.
mesh_terms: D000328:Adult; D002509:Cephaloridine / Q000097:blood / Q000378:metabolism*; D004077:Digoxin / Q000097:blood / Q000378:metabolism*; D004347:Drug Interactions; D005665:Furosemide / Q000494:pharmacology*; D005839:Gentamicins / Q000097:blood / Q000378:metabolism*; D005919:Glomerular Filtration Rate / Q000187:drug effects*; D006801:Humans; D007444:Inulin / Q000097:blood; D007668:Kidney / Q000187:drug effects / Q000378:metabolism; D008297:Male; D011217:Practolol / Q000097:blood / Q000378:metabolism*; D013997:Time Factors
chemical_list: D005839:Gentamicins; D004077:Digoxin; D005665:Furosemide; D007444:Inulin; D002509:Cephaloridine; D011217:Practolol