Reagents which inhibit disulphide bond formation stabilize human fibroblast interferon.
Fibroblast interferon may be stabilized against many inactivating influences by the addition of certain simple sulphydryl reagents. The use of such easily removable and relatively non-toxic stabilizers should help in the preparation and purification of fibroblast interferon for clinical use.
D002460:Cell Line; D003545:Cysteine / Q000031:analogs & derivatives / Q000494:pharmacology; D004355:Drug Stability; D005347:Fibroblasts; D006801:Humans; D007372:Interferons / Q000096:biosynthesis / Q000494:pharmacology*; D008168:Lung / Q000196:embryology; D010421:Pentanoic Acids / Q000494:pharmacology; D013314:Stress, Mechanical; D013439:Sulfhydryl Reagents / Q000494:pharmacology*
D010421:Pentanoic Acids; D013439:Sulfhydryl Reagents; D007372:Interferons; D003545:Cysteine