The effect of exogenous histone on the synthesis of DNA, RNA and proteins in Coxsackie B4 virus infected cells.
The incorporation of labelled precursors of DNA, RNA and proteins in F. cells infected with Coxsackie B4 virus has been traced both in the presence and absence of total histone from nucleated erythrocytes during the infectious process. In comparison with the virus infection alone, the exogenous histone supressed the incorporation of 3H-thymidine in early hours and the incorporation of 3H-uridine and 14C-leucine in the 9th hour after virus infection. The established repression of the incorporation of the labelled precurssors for RNA and proteins correlates with a drop in the order of 90 to 99% in the yield of infectious virus.
D002250:Carbon Radioisotopes; D004279:DNA, Viral / Q000096:biosynthesis; D003864:Depression, Chemical; D004770:Enterovirus / Q000187:drug effects*; D004912:Erythrocytes; D006657:Histones / Q000494:pharmacology*; D006801:Humans; D066298:In Vitro Techniques; D007930:Leucine / Q000378:metabolism; D012367:RNA, Viral / Q000096:biosynthesis; D014316:Tritium; D014529:Uridine / Q000378:metabolism; D014764:Viral Proteins / Q000378:metabolism
D002250:Carbon Radioisotopes; D004279:DNA, Viral; D006657:Histones; D012367:RNA, Viral; D014764:Viral Proteins; D014316:Tritium; D007930:Leucine; D014529:Uridine