Wheat-based diets: effect of short-term consumption on serum cholesterol and triglyceride levels in infants.
The effect of consumption of wheat-based diets on serum cholesterol and triglyceride levels was studied in eight previously malnourished children. While consuming a control diet of casein, soy-cottonseed oil blend, and a mixture of sucrose and starch, the serum cholesterol level was 169 +/- 42 mg/dl (mean +/- SD). This decreased significantly (P less than .001) to 108 +/- 30 mg/dl after nine days' consumption of an isoenergetic-isonitrogenous diet in which whole wheat or white flour provided all the protein and +/- 50% of carbohydrate, and remained at this level for the 27-day dietary period. On changing again to the casein-based diet, the serum cholesterol level rose within nine days to 154 +/- 42 mg/dl. There was no similar diet-related change in serum triglyceride values. None of the known mechanisms whereby diet affects serum cholesterol adequately explains these findings.
D001835:Body Weight; D002364:Caseins; D002784:Cholesterol / Q000097:blood*; D004032:Diet; D004043:Dietary Fiber; D005243:Feces; D006801:Humans; D007223:Infant; D014280:Triglycerides / Q000097:blood*; D014908:Triticum
D002364:Caseins; D004043:Dietary Fiber; D014280:Triglycerides; D002784:Cholesterol