Immunosuppressive effects of 3-methylcholanthrene given intratracheally in various inbred strains of mice.
The immunosuppressive effects of 3-methylcholanthrene (MCA) given intratracheally have been shown to correlate with susceptibility of some inbred strains of mice to MCA-induced carcinogenesis. In susceptible strains of mice, C3Hf and C57BL/6, intratracheal administration of MCA resulted in profound systemic immunodepression. This effect was not observed in resistant DBA/2 mice. This immunodepressive effect correlated with the inducibility of the aryl hydrocarbon hydroxylase enzyme complex and the inducibility of pulmonary tumors by MCA.
D000818:Animals; D001189:Aryl Hydrocarbon Hydroxylases / Q000378:metabolism; D005260:Female; D007166:Immunosuppressive Agents; D008175:Lung Neoplasms / Q000139:chemically induced* / Q000201:enzymology / Q000276:immunology; D008297:Male; D008748:Methylcholanthrene / Q000494:pharmacology*; D051379:Mice; D008815:Mice, Inbred Strains; D009374:Neoplasms, Experimental / Q000139:chemically induced; D013045:Species Specificity
D007166:Immunosuppressive Agents; D008748:Methylcholanthrene; D001189:Aryl Hydrocarbon Hydroxylases