Dopamine enhances the action of prolactin on rat blood vessels. Implications for dopamine effects on plasma prolactin.
It has been claimed that dopamine enhances peripheral uptake of prolactin. Dopamine at 2.1 x 10(-9)M, a concentration which had no effect by itself, enhanced both the potentiation of rat mesenteric vascular reactivity caused by 50ng/ml ovine prolactin and the inhibition of reactivity caused by 500ng/ml prolactin. These observations are consistent with the proposal that dopamine can interact peripherally with prolactin.
D000818:Animals; D004298:Dopamine / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D008297:Male; D008638:Mesenteric Arteries / Q000187:drug effects; D009638:Norepinephrine / Q000494:pharmacology; D011388:Prolactin / Q000097:blood / Q000494:pharmacology; D051381:Rats; D014661:Vasoconstriction / Q000187:drug effects
D011388:Prolactin; D004298:Dopamine; D009638:Norepinephrine