[Effect of schizophrenic patients' serum on DNA synthesis in cultures of PHA stimulated lymphocytes].
The authors studied the influence of the blood sera of schizophrenic patients on the DNA synthesis in a PHA stimulated lymphocyte culture of normal donors. It was established that in 13 of the 15 studied patients the blood sera contained factors, inhibiting the DNA synthesis in lymphocytes in normals. The reactivity of lymphocytes on the PHA was in an inverse correlation with the figure of the cytotoxic index. The assumption is being made that the inhibiting action of the serum is conditioned by the presence of antibodies to thymocytes and T-lymphocytes.
D002478:Cells, Cultured; D004247:DNA / Q000096:biosynthesis*; D006801:Humans; D007106:Immune Sera / Q000494:pharmacology*; D037102:Lectins / Q000494:pharmacology; D008213:Lymphocyte Activation; D008214:Lymphocytes / Q000378:metabolism*; D012559:Schizophrenia / Q000276:immunology*
D007106:Immune Sera; D037102:Lectins; D004247:DNA
Izuchenie vliianiia syvorotki krovi bol'nykh shizofrenieĭ na sintez DNK v kul'turakh limfotsitov, stimulirovannykh FGA.