[Thyroxine induction of aminotransferases in subcellular fractions of rat heart].
Administration of thyroxine toxic doses to rats results in a considerable increase in the alanine aminotransferase and aspartate aminotransferase activity in nuclear, mitochondrial and supernatant fractions of the rat heart. The hormone action is more pronounced in the mitochondrial fraction. A simultaneous administration of thyroxine and actinomycin D decreases the hormone effect in case of nuclear and supernatant enzymes. The enzymes of mitochondrial fractions do not change after actinomycin D injection. It is possible to suggest that in mitochondria there occurs a synthesis of some enzymes.
D000410:Alanine Transaminase / Q000096:biosynthesis*; D001219:Aspartate Aminotransferases / Q000096:biosynthesis*; D002467:Cell Nucleus / Q000201:enzymology; D003609:Dactinomycin / Q000494:pharmacology; D006321:Heart / Q000187:drug effects; D008929:Mitochondria, Heart / Q000187:drug effects / Q000201:enzymology; D009206:Myocardium / Q000201:enzymology*; D013347:Subcellular Fractions / Q000201:enzymology; D013974:Thyroxine / Q000494:pharmacology*
D003609:Dactinomycin; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase; D013974:Thyroxine
Indutsirovanie tiroksinom aminotransferaz subkletochnykh fraktsiĭ miokarda krys.