Failure to produce atherosclerosis in Macaca radiata on a high-methionine, high-fat, pyridoxine-deficient diet.
Accelerated atherosclerotic lesions are observed in genetic defects characterised by marked homocystinaemia as a result of low levels of cystathionine synthase, a pyridoxal phosphate-dependent enzyme. Attempts were therefore made to induce atherosclerosis in Macaca radiata, maintained on a high-protein, high-methionine and high-fat diet by inducing pyridoxine deficiency with deoxypyridoxine. Pyridoxine deficient monkeys failed to show any biochemical or pathological evidence of atherosclerosis, despite a significant decrease in the activity of hepatic cystathionine synthase.
D000410:Alanine Transaminase / Q000378:metabolism; D000818:Animals; D001011:Aorta / Q000378:metabolism; D001161:Arteriosclerosis / Q000209:etiology* / Q000378:metabolism; D001219:Aspartate Aminotransferases / Q000378:metabolism; D004036:Diet, Atherogenic; D004041:Dietary Fats / Q000378:metabolism; D006441:Hemoglobin A / Q000378:metabolism; D050356:Lipid Metabolism; D008055:Lipids / Q000097:blood; D008099:Liver / Q000201:enzymology; D008255:Macaca radiata; D008297:Male; D008715:Methionine / Q000378:metabolism; D011736:Pyridoxine / Q000378:metabolism; D026681:Vitamin B 6 Deficiency / Q000150:complications / Q000378:metabolism*
D004041:Dietary Fats; D008055:Lipids; D006441:Hemoglobin A; D008715:Methionine; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase; D011736:Pyridoxine