title: [Undifferentiated X-linked oligophrenias].
abstract: In the course of investigation of 262 families with non-differentiated forms of oligophrenias it is established that in 48 families (18.3%) mental deficiency in sibs is caused by pathological mutations in the X-chromosome. Besides, it is not excluded that in certain inbred families oligophrenia in female persons is also, due to mutations linked with X-chromosome. This is supported by the dependence established between the frequency of the cases of oligophrenia among female persons and the inbreeding coefficient for the X-linked loci. The possibility of manifestation of the recessive genes of oligophrenia linked with X-chromosomes in heterozygous state is discussed.
mesh_terms: D005260:Female; D006801:Humans; D007178:Inbreeding; D008607:Intellectual Disability / Q000235:genetics*; D008297:Male; D012729:Sex Chromosome Aberrations; D012730:Sex Chromosomes; D014960:X Chromosome
vernacular_title: Nedifferentsirovannye X-stseplennye oligofrenii.