Effect of thiopentone on myocardial function.
In a canine preparation designed to separate myocardial from peripheral cardiovascular effects of the drug. It was found that thiopentone produced minimal depression of the heart. Only in much greater concentrations was significant depression found. It is concluded that the cardiovascular effects of thiopentone i.v. are not a direct effect on the heart.
D000818:Animals; D003864:Depression, Chemical; D004285:Dogs; D006321:Heart / Q000187:drug effects*; D006439:Hemodynamics / Q000187:drug effects; D009200:Myocardial Contraction / Q000187:drug effects; D013874:Thiopental / Q000494:pharmacology*
D013874:Thiopental