Comparative pharmacokinetics of coumarin anticoagulants XXIX: Elimination kinetics and anticoagulant activity of (S)-(-)-warfarin in rats before and after chronic administration.
The kinetics of elimination and the anticoagulant effect of (S)-(-)-warfarin were determined in adult male rats before and after daily drug administration for 13 days. There was a small but statistically significant (p less than 0.05) decrease in the body clearance of (S)-(-)-warfarin (from 4.84 to 4.37 ml/hr/kg) and an increase in the serum free fraction of racemic warfarin (added to serum in vitro) from 0.00850 to 0.0107 (p less than 0.05). The concentration of (S)-(-)-warfarin in serum at which the synthesis rate of prothrombin complex activity is one-half of the pre-warfarin rate increased from 0.532 to 0.655 microgram/ml on the average (p less than 0.05).
D000818:Animals; D000925:Anticoagulants; D001780:Blood Coagulation Tests; D006207:Half-Life; D007700:Kinetics; D008297:Male; D051381:Rats; D013997:Time Factors; D014859:Warfarin / Q000008:administration & dosage / Q000097:blood* / Q000494:pharmacology
D000925:Anticoagulants; D014859:Warfarin