Tissue distribution studies with radioactive manganese: a potential agent for myocardial imaging.
Manganese, a trace metal, is known to localize in mitochondria. Because mitochondria are abundant in heart muscle, the possible utility of radioactive manganese as a myocardial imaging agent was examined in 25 rats and six dogs. Myocardial uptake of Mn-54 in rats was found to exceed that of thallium-201; myocardium-to-blood ratios averaged 306:1 versus 48:1 for Tl-201. In the dog, uptake of Mn-54 by ischemic myocardium was reduced by 17-75% compared with normal myocardium. Thus, radioactive manganese appears promising as an intravenous myocardial imaging agent, and might be useful in studying the function of myocardial mitochondria by external imaging.
D000818:Animals; D004285:Dogs; D008345:Manganese; D009203:Myocardial Infarction / Q000175:diagnosis*; D011868:Radioisotopes; D011877:Radionuclide Imaging; D051381:Rats
D011868:Radioisotopes; D008345:Manganese