The effect of vincristine on haemoglobin synthesis.
Vincristine in a concentration of 0.5 and 4 X 10--(5) M causes a decrease of 16% and 73% respectively, in the synthesis of globin by peripheral blood reticulocytes. At the higher drug concentration alpha/beta ratio is significantly lower than the normal ratio of unity and is 0.83 +/- 0.09. These effects of vincristine are probably related to the ability of the vinca alkaloids to bind to ribosomes and their subunits.
D003864:Depression, Chemical; D006454:Hemoglobins / Q000096:biosynthesis*; D006801:Humans; D012156:Reticulocytes / Q000378:metabolism*; D014750:Vincristine / Q000494:pharmacology*
D006454:Hemoglobins; D014750:Vincristine