Self-stimulation of the subfornical organ and lateral hypothalamus: differential effects of atropine and methysergide.
The effects of cholinergic blockade of neurons by atropine or serotonergic blockade by methysergide was investigated in rats responding for brain-stimulation reward. Bipolar stimulating electrodes were placed either in the subfornical organ (SFO) or the lateral hypothalamus (LH). Atropine sulphate and methysergide significantly suppressed self-stimulation of the SFO but not of the LH, suggesting that cholinergic and serotonergic neurons are involved in brain-stimulation reward associated with this site.
D000661:Amphetamine / Q000494:pharmacology; D000818:Animals; D001285:Atropine / Q000494:pharmacology*; D001921:Brain / Q000033:anatomy & histology; D003913:Dextroamphetamine / Q000494:pharmacology; D007031:Hypothalamus / Q000502:physiology*; D008297:Male; D008784:Methysergide / Q000494:pharmacology*; D009490:Neurosecretory Systems / Q000502:physiology*; D010424:Pentobarbital / Q000494:pharmacology; D051381:Rats; D012653:Self Stimulation / Q000187:drug effects*; D013356:Subfornical Organ / Q000502:physiology*
D001285:Atropine; D000661:Amphetamine; D010424:Pentobarbital; D003913:Dextroamphetamine; D008784:Methysergide