Blockade of delta9-thc induced hypothermia in rats.
Pretreatment of rats with 6-hydroxydopamine over a narrow dose range (100 mg/kg i.p.), attenuated the hypothermic response elicited by administration of delta9-tetrahydrocannabinol (delta9-THC) (10 mg/kg i.p.). Pretreatment with hexamethonium (10 mg/kg i.p.) also attenuated the response. These findings suggest that the hypothermic response produced by delta9-THC administration in the rat is related to alteration of autonomic outflow.
D000818:Animals; D001831:Body Temperature / Q000187:drug effects*; D003864:Depression, Chemical; D013759:Dronabinol / Q000037:antagonists & inhibitors* / Q000494:pharmacology; D006584:Hexamethonium Compounds / Q000494:pharmacology*; D006892:Hydroxydopamines / Q000494:pharmacology*; D066298:In Vitro Techniques; D008297:Male; D009200:Myocardial Contraction / Q000187:drug effects; D051381:Rats; D013997:Time Factors; D014439:Tyramine / Q000494:pharmacology
D006584:Hexamethonium Compounds; D006892:Hydroxydopamines; D013759:Dronabinol; D014439:Tyramine