title: [Studies on the interactions of phenprocoumon with chlordiazepoxide in rats (author's transl)].
abstract: The influence of Chlordiazepoxide (Librium) on the anticoagulating activity of Phenprocoumon (Marcumar) was investigated in rats. It was found that this psychotropic drug influences neither the anticoagulating activity nor the normal prothrombin-time when it is applied alone or together with Phenprocoumon. However, the prothrombin-time is shortened when Chlordiazepoxide is withdrawn and the feeding of Phenprocoumon is continued.
mesh_terms: D015110:4-Hydroxycoumarins / Q000494:pharmacology*; D000818:Animals; D002707:Chlordiazepoxide / Q000494:pharmacology*; D004347:Drug Interactions; D005260:Female; D007700:Kinetics; D008297:Male; D010644:Phenprocoumon / Q000494:pharmacology*; D011517:Prothrombin Time; D051381:Rats
chemical_list: D015110:4-Hydroxycoumarins; D002707:Chlordiazepoxide; D010644:Phenprocoumon
vernacular_title: Zur Interaktion von Phenoprocoumon mit Chlordiazepoxid.