Prevention of 2-acetylaminofluorene-induced extrahepatic short-term effects by 3-methylcholanthrene.
It is well known that simultaneous application of polycyclic carcinogenic hydrocarbons, especially 3-methylcholanthrene (MC) inhibits or prevents tumorigenesis induced by carcinogenic aromatic amines or azo dyes. Short-term tests showed a mitogenic effect upon adrenal cortex 48 hours following a single dose of 2-acetylaminofluorene (AAF) among other carcinogenic substances. 6 mg/kg body weight given simultaneously prevent the proliferative response of the adrenals by AAF (60 mg/kg b.w.) in male Sprague-Dawley rats. These different effects can be assumed to depend on the production of carcinogenic derivatives or their non-production. Therefore, the positive adrenal reaction by other substances tested is probably also provoked by carcinogenic compounds. The lack of responsiveness by MC may reflect a fundamental change of AAF metabolism. The mode of action is unknown. Possible explanations are discussed.
D015073:2-Acetylaminofluorene / Q000494:pharmacology*; D000311:Adrenal Glands / Q000187:drug effects; D000818:Animals; D002273:Carcinogens; D005449:Fluorenes / Q000494:pharmacology*; D008099:Liver / Q000187:drug effects; D008297:Male; D008748:Methylcholanthrene / Q000037:antagonists & inhibitors*; D008938:Mitosis / Q000187:drug effects; D009929:Organ Size / Q000187:drug effects; D051381:Rats; D013154:Spleen / Q000187:drug effects
D002273:Carcinogens; D005449:Fluorenes; D008748:Methylcholanthrene; D015073:2-Acetylaminofluorene