Pirimicarb induced immune haemolytic anaemia in dogs.
The feeding of pirimicarb (2-dimethylamino-5,6-dimethylpyrimidin-4-yl dimethylcarbamate) to normal beagle dogs resulted in anaemia in a small number of animals. Dosing studies confirmed pirimicarb as the causative agent and the anaemia was characterised as haemolytic. Serological tests revealed the presence of an IgG antibody active only in the presence of pirimicarb. The level of antibody detected was related to the dose of pririmicarb given.
D000743:Anemia, Hemolytic / Q000139:chemically induced* / Q000276:immunology; D000818:Animals; D002219:Carbamates; D055598:Chemical Phenomena; D002621:Chemistry; D003298:Coombs Test; D004285:Dogs; D004305:Dose-Response Relationship, Drug; D005260:Female; D007074:Immunoglobulin G / Q000032:analysis; D007306:Insecticides / Q000008:administration & dosage / Q000633:toxicity*; D008297:Male; D011743:Pyrimidines / Q000008:administration & dosage / Q000633:toxicity
D002219:Carbamates; D007074:Immunoglobulin G; D007306:Insecticides; D011743:Pyrimidines; C011994:pirimicarb