[Determination of plasma digoxin in newborn infants. Practical applications].
Measurement of plasma digoxin concentrations in infants after three increasing dosage levels shows that the optimal dose of this glycoside in 20 microgram/kg/day, i.e. a loading dose of 20 microgram/kg followed every 8 hours by a maintenance dose of 7 microgram/kg. The plateau concentration achieved is 3.0 +/- 0,5 ng/ml 8 hours after the last administration. When digoxin levels exceed 5 ng/ml (overdosage, renal failure or low body weight), toxic manifestations occur.
D004077:Digoxin / Q000008:administration & dosage / Q000097:blood* / Q000506:poisoning; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D008297:Male
D004077:Digoxin
Le dosage de la digoxine plasmatique chez le nouveau-né. Applications pratiques.