Serum bile acids in man during vitamin C supplementation and restriction.
A daily dosage of 5 g ascorbate was given to 14 persons during one month. Various routine biochemical parameters were studied and the concentrations of individual bile acids in serum were determined. A significant increase in chenodeoxycholic acid concentration was found on interruption of vitamin C supplementation, whereas no other changes in bile acid concentrations were significant. One person, used to a large ascorbate intake (1 g/day), was deprived of ascorbate. On resuming the high ascorbate intake, serum bile acid concentrations showed an increasing trend. Urinary oxalate excretion and concentrations were impressively increased during vitamin C supplementation but no effects on kidney function were observed.
D000328:Adult; D001205:Ascorbic Acid / Q000008:administration & dosage; D001647:Bile Acids and Salts / Q000097:blood*; D003404:Creatinine / Q000652:urine; D006801:Humans; D008297:Male; D010070:Oxalates / Q000652:urine; D010710:Phosphates / Q000097:blood; D013997:Time Factors
D001647:Bile Acids and Salts; D010070:Oxalates; D010710:Phosphates; D003404:Creatinine; D001205:Ascorbic Acid