The metabolic effects of excess noradrenaline secretion from a pheochromocytoma.
We report a 14-year-old boy with severe hypertension who was cured by surgical removal of a pheochromocytoma. The tumor was shown biochemically and morphologically to secrete predominantly noradrenaline. The metabolic effects noted in this patient were raised free fatty acid levels and depressed insulin levels, hyperreninemia, hypercalcemia, and hypercalciuria with normal parathyroid function. All these abnormalities returned to normal after removal of the tumor. It is suggested that these effects were mediated via beta-adrenergic stimulation of the excess noradrenaline.
D000293:Adolescent; D000310:Adrenal Gland Neoplasms / Q000378:metabolism* / Q000473:pathology / Q000601:surgery; D002118:Calcium / Q000652:urine; D005230:Fatty Acids, Nonesterified / Q000097:blood*; D006801:Humans; D006934:Hypercalcemia / Q000209:etiology*; D006973:Hypertension / Q000378:metabolism / Q000503:physiopathology / Q000628:therapy; D007328:Insulin / Q000097:blood*; D008297:Male; D009638:Norepinephrine / Q000378:metabolism*; D010673:Pheochromocytoma / Q000378:metabolism* / Q000473:pathology / Q000601:surgery; D012083:Renin / Q000097:blood*
D005230:Fatty Acids, Nonesterified; D007328:Insulin; D012083:Renin; D002118:Calcium; D009638:Norepinephrine