Suppressed tumor growth and metastasis by vitamin A + BCG in Lewis lung tumor bearing mice.
The anti-tumor effect of vitamin A and/or BCG was investigated in Lewis lung tumor system. Tumor growth and lung metastases were significantly suppressed, when tumor cells were mixed with BCG and inoculated subcutaneously into vitamin A-treated animals. Survival time was also prolonged by the same treatment. Vitamin A alone, without BCG, showed no effect on tumour growth, lung metastases or survival time.
D000818:Animals; D001500:BCG Vaccine / Q000627:therapeutic use*; D007109:Immunity / Q000187:drug effects; D008175:Lung Neoplasms / Q000276:immunology / Q000628:therapy*; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D008811:Mice, Inbred DBA; D009362:Neoplasm Metastasis / Q000628:therapy; D009374:Neoplasms, Experimental / Q000628:therapy; D014801:Vitamin A / Q000627:therapeutic use*
D001500:BCG Vaccine; D014801:Vitamin A