title: [Metabolic diseases and fatty liver].
abstract: Issuing from the first observations which gave rise to suppose a connection between the fatty degeneration of the liver and the diabetic disturbances of metabolism the at present existing opinions on the development of the fatty degeneration of the liver, its frequency and treatment are demonstrated. According to recent investigation there is a fundamental difference in the regulation of the accumulation of the triglycerides between the healthy persons with normal weight and diabetics as well as the persons with overweight after addition of carbohydrate. While in persons with normal weight the accumulation of triglycerides is reduced by carbohydrates, on account of the overweight a disturbance is produced in the liver which is characterized by inversion and decrease of the elimination activity of triglycerides. Neither the diabetes nor the fatty acids in the blood nor the carbohydrate or fat accumulation primarily cause a fatty degeneration of the liver. The disturbance of the elimination activity is evoked by the overweight. In dependence upon the body-weight the metabolism of the diabetics with overweight and underweight also differs concerning the insulin secretion and by the size of the glycogen accumulation and the behaviour in the degradation of the glycogen of the liver (decreased degradation in diabetics with overweight). The fatty degeneration of the liver as an expression of a disturbance of the regulation as a consequence of the overweight justifies the old classification of the diabetes in an insulin deficiency diabetes and a counter-regulation diabetes.
mesh_terms: D001835:Body Weight; D005234:Fatty Liver / Q000209:etiology* / Q000378:metabolism; D006801:Humans; D007328:Insulin / Q000378:metabolism; D008112:Liver Glycogen / Q000378:metabolism; D009765:Obesity / Q000150:complications* / Q000378:metabolism; D014280:Triglycerides / Q000378:metabolism
chemical_list: D007328:Insulin; D008112:Liver Glycogen; D014280:Triglycerides
vernacular_title: Erkrankungen des Stoffwechsels und die Fettleber.