title: Enhancement of sexual behavior in the female rat by nicotine.
abstract: The effects of nicotine alone or in combination with mecamylamine, and the effects of both in combination with DA agonists and antagonists and d-LSD (5-HT agonist) have been studied on the sexual behaviour of castrate, estrogen-treated female rats. The results show that nicotine (as low as 50 mug/kg) significantly increases sexual receptivity. The pharmacological analysis suggests this effect to be mediated by a central, nicotine-like cholinergic receptor whose relationship to DA and 5-HT pathways known to exert inhibitory influences on receptivity in the female rat is also discussed.
mesh_terms: D000818:Animals; D001058:Apomorphine / Q000494:pharmacology; D002369:Castration; D005260:Female; D008238:Lysergic Acid Diethylamide / Q000494:pharmacology; D008464:Mecamylamine / Q000494:pharmacology; D009538:Nicotine / Q000494:pharmacology*; D010868:Pimozide / Q000494:pharmacology; D051381:Rats; D011954:Receptors, Dopamine / Q000187:drug effects; D011985:Receptors, Serotonin / Q000187:drug effects; D012726:Sexual Behavior, Animal / Q000187:drug effects*; D013268:Stimulation, Chemical; D013469:Sulpiride / Q000494:pharmacology
chemical_list: D011954:Receptors, Dopamine; D011985:Receptors, Serotonin; D010868:Pimozide; D008464:Mecamylamine; D009538:Nicotine; D013469:Sulpiride; D008238:Lysergic Acid Diethylamide; D001058:Apomorphine