Toxicity of selected antibiotics in vitreous replacement fluid.
Experiments with rabbits demonstrated no toxic effects on the retina after vitrectomy when the infusion fluid contained either 20 microgram/ml chloramphenicol saline, 10 microgram/ml amikacin saline, 10 microgram/ml tobramycin saline, or 10 microgram/ml clindamycin saline. We found abnormal electroretinograms and abnormal histologic findings in eyes receiving vitreous replacement with these same drugs in higher concentrations.
D000583:Amikacin / Q000633:toxicity; D000818:Animals; D000900:Anti-Bacterial Agents / Q000633:toxicity*; D001672:Biocompatible Materials / Q000633:toxicity; D002701:Chloramphenicol / Q000633:toxicity; D002981:Clindamycin / Q000633:toxicity; D011817:Rabbits; D012160:Retina / Q000187:drug effects*; D012965:Sodium Chloride / Q000008:administration & dosage*; D014031:Tobramycin / Q000633:toxicity; D014822:Vitreous Body / Q000601:surgery*
D000900:Anti-Bacterial Agents; D001672:Biocompatible Materials; D002981:Clindamycin; D012965:Sodium Chloride; D002701:Chloramphenicol; D000583:Amikacin; D014031:Tobramycin