title: A new in vivo method of quantitating the rate of magnitude of mineralization of an experimental osseous defect.
abstract: An in vivo, quantitative, non-destructive method of measuring bone mineral deposition in a repairing osseous defect has been developed. A circular osteotomy, used as a controlled fracture, was found to be extremely reproducible, and could be introduced with a minimum of trauma. The rate and magnitude of mineralization of the osteotomy was directly related to the attenuation of a highly collimated photon beam produced by Iodine-125. Changes in bone mineral content of 4% can be detected using this system.
mesh_terms: D000818:Animals; D002113:Calcification, Physiologic; D002645:Chickens; D050723:Fractures, Bone; D007457:Iodine Radioisotopes; D008722:Methods; D014945:Wound Healing
chemical_list: D007457:Iodine Radioisotopes