[Effect of serotonin and monoamine oxidase inhibitors on corneal anesthesia produced by celnovocaine and novocaine].
In experiments on guinea pigs it is shown that a preliminary intraperitoneal administration of monoamine oxidase inhibitors (MAOI) -- transamine (10 mg/kg) or malic acid benzyldihydrazide (50 mg/kg) antagonizes the local anesthetic action of celnovocaine (CC) and novocaine (NC). An analogous effect is also observed following instillation of transamine (a 0.1% solution) and malic acid benzyldihydrazide (a 0.23% solution) into the eye 10 minutes before administration of the anesthetic. Instillation of a 0.1% serotonin creatinine sulphate solution also antagonizes anesthesia produced by CC and NC, while MAOI potentiates the effect of serotonin.
D000772:Anesthesia, Local; D000818:Animals; D003315:Cornea / Q000187:drug effects*; D006016:Glycolates / Q000037:antagonists & inhibitors; D006168:Guinea Pigs; D006834:Hydrazines / Q000494:pharmacology; D008293:Malates / Q000494:pharmacology; D008996:Monoamine Oxidase Inhibitors / Q000494:pharmacology*; D011343:Procaine / Q000037:antagonists & inhibitors* / Q000031:analogs & derivatives; D012701:Serotonin / Q000494:pharmacology*; D014191:Tranylcypromine / Q000494:pharmacology
D006016:Glycolates; D006834:Hydrazines; D008293:Malates; D008996:Monoamine Oxidase Inhibitors; D012701:Serotonin; C006942:celnovocaine; D014191:Tranylcypromine; D011343:Procaine
Vliianie serotonina i ingibitorov monaaminaksidazy no anesteziiu rogovitsy, vyzyvaemuiu tselnovokainom i novokainom.