[Investigation of the c. s. fluid levels of two newer antibiotics; cefazolin and sisomicin (author's transl)].
In ten patients continuous estimations of the C.S.F. and serum levels were performed after the administration of a Cephalosporin derivative (Cefazolin - 4 cases) and a new alpha-amino-glycoside antibiotic (Sisomicin - 6 cases). After the evaluation of the results some doubts must be cast on the value of both these antibiotics for the treatment of meningitis or for per-operative chemo-prophylaxis in neurosurgical procedures. The values found were compared with those well-known in the literature, regarding the cephalosporins and the alpha-amino-glycoside Gentamycin.
D000293:Adolescent; D000328:Adult; D000900:Anti-Bacterial Agents / Q000134:cerebrospinal fluid*; D002437:Cefazolin / Q000097:blood / Q000134:cerebrospinal fluid*; D002511:Cephalosporins / Q000134:cerebrospinal fluid*; D002648:Child; D002675:Child, Preschool; D005839:Gentamicins / Q000134:cerebrospinal fluid; D006801:Humans; D008875:Middle Aged; D012853:Sisomicin / Q000097:blood / Q000134:cerebrospinal fluid*
D000900:Anti-Bacterial Agents; D002511:Cephalosporins; D005839:Gentamicins; D002437:Cefazolin; D012853:Sisomicin
Liquorspiegeluntersuchung zwei neuerer Antibiotika Cefazolin und Sisomicin.