title: Changes of the CO-diffusing components of the lung in patients with coronary artery disease (author's transl).
abstract: In 32 patients with angiographically proved CAD the diffusion parameters of the lung (intracapillary pulmonary blood volume, Vc, and diffusion capacity of the alveolo-capillary membrane, Dm, respectively the reciprocal value membrane resistance) were measured. As reference the pre-a-LVDP was used, as it represents more adequately than the LVEDP the pressure acting on the alveolo-capillary membrane. There was a significant positive correlation between the Vc and the pre-a-LVDP as well as a highly significant positive correlation between the diffusion resistance of the alveolo-capillary membrane and the pre-a-LVDP. This corresponds to a pulmonary congestion with an increase of Vc and an interstitial edema with an increase of the diffusion resistance of the alveolo-capillary membrane. The Dco may be unchanged in spite of a marked increase of LVDP, since the decrease of the membrane component is accompanied by an increase of the blood component of diffusion. Only the differentiation of the CO-transfer in its components Vc and Dm gives an information about changes of the hemodynamics in CAD.
mesh_terms: D001794:Blood Pressure; D002245:Carbon Dioxide; D003327:Coronary Disease / Q000175:diagnosis*; D006801:Humans; D011652:Pulmonary Circulation; D011653:Pulmonary Diffusing Capacity
chemical_list: D002245:Carbon Dioxide
vernacular_title: Veränderungen der Diffusionsparameter der Lunge bei der koronaren Herzerkrankung (KHK).