[Hypotensive effect of intensifying aldosterone metabolism in dogs with vasorenal hypertension].
The mechanisms of hypotensive effect of the portacaval transposition of the vessels in dogs with vaso-renal hypertension were studied. The direction of renal and adrenal venous blood to the liver in hypertensive dogs led to an increase in aldosterone metabolism, and, at the same time, to a rise of the hormone secretion by the adrenal glands; as a result the steroid level in the peripheral blood remained unchanged. Elimination of the syndrome of secondary hyperaldosteronism with the aid of porta-caval transposition occurred on account of an increase in aldosterone metabolism and led to the arterial pressure normalization.
D000450:Aldosterone / Q000378:metabolism* / Q000502:physiology; D000818:Animals; D004285:Dogs; D005260:Female; D006977:Hypertension, Renal / Q000378:metabolism*; D007022:Hypotension / Q000378:metabolism*; D008297:Male; D008657:Metabolic Clearance Rate; D011167:Portacaval Shunt, Surgical; D012078:Renal Artery Obstruction / Q000378:metabolism; D012083:Renin / Q000097:blood; D013997:Time Factors
D000450:Aldosterone; D012083:Renin
Gipotenzivnyĭ éffekt usileniia metabolizma al'dosterona u sobak s vazorenal'noĭ gipertonieĭ.