title: Epileptiform seizures in domestic fowl. VI. Plasma phenobarbital concentrations and anticonvulsant activity.
abstract: The relationship between plasma phenobarbital concentrations and anticonvulsant activity was determined against seizures induced in epileptic chickens by intermittent photic stimulation (IPS). Intraperitoneally administered phenobarbital produced a plasma-concentration-dependent reduction in both the incidence and severity of seizures. Complete protection against IPS-induced seizures was observed for a period of 6 h after acute phenobarbital administration during which the mean plasma phenobarbital concentrations were between 16.2 +/- 0.91 and 13.6 +/- 1.0 microgram/lm. Plasma phenobarbital concentrations below 3.6 +/- 0.06 microgram/ml had no measurable effect.
mesh_terms: D000818:Animals; D000927:Anticonvulsants; D002645:Chickens / Q000378:metabolism / Q000502:physiology*; D004827:Epilepsy / Q000097:blood / Q000503:physiopathology / Q000662:veterinary*; D010634:Phenobarbital / Q000097:blood / Q000494:pharmacology*; D010775:Photic Stimulation; D011201:Poultry Diseases / Q000097:blood / Q000503:physiopathology*; D013997:Time Factors
chemical_list: D000927:Anticonvulsants; D010634:Phenobarbital