title: Episodic nocturnal wanderings responsive to anticonvulsant drug therapy.
abstract: Six patients between the ages of 17 and 32 years presented with unusual sleep-walking epidodes characterized by screaming or unintelligible vocalizations; complex, often violent automatisms; and ambulation. Two or more attacks could occur in a single night and were most common in the early morning hours. Family and personal histories did not show epilepsy, psychiatric disorders, or (with 1 exception) previous somnambulism. Electrographic investigation revealed that all patients had normal waking-sleep cycles but that 4 of them had epileptiform abnormalities on their electroencephalograms. All patients were treated with either phenytoin or carbamazepine, with cessation of the abnormal nocturnal behavior during follow-up periods ranging from 9 to 48 months. This syndrome appears to be distinct from more typical non-rapid eye movement dyssomnias and suggests an atypical form of epilepsy.
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D002220:Carbamazepine / Q000627:therapeutic use*; D004569:Electroencephalography; D006801:Humans; D008297:Male; D010672:Phenytoin / Q000627:therapeutic use*; D012894:Sleep Stages; D013009:Somnambulism / Q000188:drug therapy* / Q000503:physiopathology; D013577:Syndrome; D014851:Wakefulness
chemical_list: D002220:Carbamazepine; D010672:Phenytoin