Interactions of indomethacin with lysosomes and proteins.
The stabilizing action of indomethacin on lysosomes and protein in vivtro was studied. The magnitude of the stabilizing action on lysosomes was greater than that of aspirin or oxyphenbutazone, similar to that of phenylbutazone, but less than that of prednisolone. The stabilizing action of indomethacin on lysosomes possibly may contribute to its anti-inflammatory  properties.
D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology; D066298:In Vitro Techniques; D007213:Indomethacin / Q000494:pharmacology*; D008247:Lysosomes / Q000187:drug effects*; D010047:Ovalbumin / Q000378:metabolism*; D051381:Rats
D000893:Anti-Inflammatory Agents; D010047:Ovalbumin; D007213:Indomethacin