title: [Histamine levels in the blood of humans experimental animals under normal conditions and following vaccination].
abstract: The authors present the results of study of the blood histamine content in intact rabbits and in the animals to which commercial vaccines with a different degree of reactogenic property for man were administered. The blood histamine level was also studied in practically healthy individuals and in those vaccinated with inactivated tick-borne encephalitis vaccine. The blood histamine content varied in intact rabbits from 4 to 10 microgram/ml, averaging 6.4 +/- 0.09 microgram/ml. Animal immunization caused elevation of the blood histamine content correlating with the reactogenic properties of the preparations for man: vaccines with low reactogenic properties--inactivated encephalitis and live measles vaccine produced no significant changes in the index under study; as to the typhoid vaccine with sextatoxoid, and smallpox vaccine with marked reactogenic properties--they stimulated significant histaminemia in rabbits. Revaccination of man against tick-borne encephalitis with  the inactivated cultural vaccine caused an increase in the blood histamine content.
mesh_terms: D000818:Animals; D002682:Chinchilla; D004165:Diphtheria / Q000517:prevention & control; D004675:Encephalitis, Tick-Borne / Q000097:blood / Q000517:prevention & control*; D006632:Histamine / Q000097:blood*; D008457:Measles / Q000517:prevention & control; D011817:Rabbits; D011818:Rabies / Q000517:prevention & control; D012899:Smallpox / Q000517:prevention & control; D013742:Tetanus / Q000517:prevention & control; D014435:Typhoid Fever / Q000517:prevention & control; D014611:Vaccination; D014917:Whooping Cough / Q000517:prevention & control
chemical_list: D006632:Histamine
vernacular_title: Uroven' gistamina v krovi liudeĭ i éksperimental'nykh zhivotnykh v norme i pri vaktsinatsii.