Effect of D(-)penicillamine on chronic experimental arthritis in rabbits.
Preliminary observations on the effect of D(-)penicillamine on chronic antigen-induced experimental arthritis in rabbits are reported. Daily oral administration of penicillamine, at a dose equivalent to that usually administered to rheumatoid arthritis patients, diminished the arthritis in 2 out of 3 animals as assessed by both measurement of joint circumference and histological examination.
D000818:Animals; D001168:Arthritis / Q000188:drug therapy*; D001169:Arthritis, Experimental / Q000188:drug therapy* / Q000473:pathology; D001699:Biometry; D006614:Hindlimb / Q000473:pathology; D010396:Penicillamine / Q000627:therapeutic use*; D011817:Rabbits
D010396:Penicillamine