Studies on cell recognition in the developing brain.
Several lines of evidence demonstrate cell-cell receptors on the surface of developing brain cells. Plasma membrane vesicles with regional and temporal binding specificities can be prepared. Active factors that block cell aggregation can be extracted from these membranes and partially purified. Quantitative studies of cell-cell adhesion demonstrate a gradient of adhesive specificity along the dorsoventral axis of the developing retina.
D000818:Animals; D001665:Binding Sites; D001921:Brain / Q000196:embryology*; D002448:Cell Adhesion; D002449:Cell Aggregation; D002462:Cell Membrane / Q000502:physiology; D002642:Chick Embryo; D009474:Neurons / Q000166:cytology*; D012160:Retina / Q000166:cytology