The effect of pretreatment with reserpine on the diastolic potential of guinea-pig atrial cells.
It has previously been suggested that the reserpine-induced nonspecific increase in sensitivity of the guinea-pig heart to the chronotropic effect od drugs occurs as a result of an alteration in the electrophysiological properties of the cell membrane. The results obtained in the present study provide support for this suggestion. The diastolic potential of atrial cells of perfused hearts obtained from guinea pigs treated with rerpine (0.1 mg/kg/day) for 7 days was significantly less than control. This treatment schedule of reserpine results in a significant increase in the sensitivity of perfoused hearts to the chronotropic effects of drugs...
D000200:Action Potentials / Q000187:drug effects; D000818:Animals; D016275:Atrial Function; D004305:Dose-Response Relationship, Drug; D006168:Guinea Pigs; D006321:Heart / Q000187:drug effects; D006339:Heart Rate / Q000187:drug effects; D066298:In Vitro Techniques; D008297:Male; D008564:Membrane Potentials / Q000187:drug effects*; D009200:Myocardial Contraction / Q000187:drug effects*; D009638:Norepinephrine / Q000494:pharmacology; D010477:Perfusion; D012110:Reserpine / Q000494:pharmacology*; D012996:Solutions
D012996:Solutions; D012110:Reserpine; D009638:Norepinephrine