[Consumption coagulopathy in a patient with metastatic renal carcinoma (author's transl)].
Chronic disseminated intravascular coagulation with secondary hyperfibrinolysis occurred in a patient with metastatic renal carcinoma. In the beginning the treatment with heparin was successfull. Heparindosage up to 35 000 E/day could never suppress this process completely. The value of determining thrombintime, concentration of fibrin splitting products, coagulation factors II, V, VII, IX, X and XIII, antithrombins II and III in controlling heparintherapy is discussed. Besides thrombintime and platelets the determination of fibrin splitting products is another substantial factor in controlling treatment of chronic intravascular coagulation. The patient died of myocardial rupture with heart tamponade, caused by a great intramyocardial metastasis.
D000230:Adenocarcinoma / Q000097:blood / Q000150:complications*; D000368:Aged; D002908:Chronic Disease; D004211:Disseminated Intravascular Coagulation / Q000097:blood / Q000150:complications* / Q000188:drug therapy; D005342:Fibrinolysis; D006338:Heart Neoplasms; D006493:Heparin / Q000008:administration & dosage / Q000627:therapeutic use; D006801:Humans; D007680:Kidney Neoplasms / Q000097:blood / Q000150:complications*; D008297:Male; D009362:Neoplasm Metastasis
D006493:Heparin
Chronische Verbrauchskoagulopathie bei metastasierendem Hypernephrom