Memory: proline induces retrograde amnesia in chicks.
Intracerebral injection of L-proline, 1 minute after one-trial avoidance training of chicks, impaired memory 24 hours later. Chicks injected with proline 1 or 4 hours after training and controls injected with L-isoleucine at intervals after training, showed no impairment of memory 24 hours after training. The retrograde impairment of long-term memory induced by proline occurred without the convulsions or electrographic events usually associated with retrograde amnesic treatments.
D000647:Amnesia / Q000139:chemically induced*; D000648:Amnesia, Retrograde / Q000139:chemically induced*; D000818:Animals; D002645:Chickens; D006801:Humans; D007532:Isoleucine / Q000494:pharmacology; D008297:Male; D008568:Memory / Q000187:drug effects* / Q000502:physiology; D008959:Models, Neurological; D011392:Proline / Q000008:administration & dosage / Q000494:pharmacology; D013997:Time Factors
D007532:Isoleucine; D011392:Proline