Synthesis and characterization of blood compatible surfaces. Part I. Dynamic tube test applied to heparinized surfaces.
A 3 yr study has shown that this test procedure can monitor subtle differences in surface chemistry with a high degree of reproducibility. Based on the present studies, the test appears to be a valid screening tool for examining materials in a dynamic flow situation without the need for animal sacrifice often associated with blood testing. Also, due to the small amount of blood required, numerous samples can be run on the same animal which is extremely advantageous when comparing treatment methods. In addition, the simplicity of the test should make it easily adaptable to most blood testing laboratories.
D000818:Animals; D001672:Biocompatible Materials; D001769:Blood; D001777:Blood Coagulation / Q000187:drug effects; D004285:Dogs; D006493:Heparin / Q000494:pharmacology; D013499:Surface Properties
D001672:Biocompatible Materials; D006493:Heparin