[Study of methods of inactivating a concentrated, purified cultured antirabies vaccine].
Two methods of inactivation, with ultraviolet (UV) and gamma (gamma) rays, of the concentrated purified tissue culture rabies vaccine from the Vnukovo-32 strain were studied. Under the optimal conditions of treatment of 100-fold concentrated purified virus-containing suspension, a completely inactivated vaccine with high immunogenicity indices (4.1 to 78) was obtained. Both the inactivation methods were found to be of equal value.
D000917:Antibody Formation / Q000187:drug effects; D005720:Gamma Rays; D008722:Methods; D011819:Rabies Vaccines / Q000302:isolation & purification / Q000528:radiation effects*; D014466:Ultraviolet Rays; D014613:Vaccines, Attenuated / Q000528:radiation effects
D011819:Rabies Vaccines; D014613:Vaccines, Attenuated
Izuchenie metodov inaktivatsii kontsentrirovannoĭ ochishchennoĭ kul'tural'noĭ antirabicheskoĭ vaktsiny.