Blood compatibility of silicone rubber chemically coated with cross-linked albumin.
A new method is reported for chemically coating cross-linked albumin onto silicone rubber in an attempt to improve the blood compatibility of the material. Promising results were obtained in an evaluation using both vena cava and renal embolus antithrombogenicity tests ondogs. Coated silicone rubber rings induced much less renal emboli than uncoated ones after one week implantation.
D000418:Albumins; D000818:Animals; D001012:Aorta, Abdominal; D001672:Biocompatible Materials; D001769:Blood; D001777:Blood Coagulation; D001807:Blood Vessel Prosthesis; D004285:Dogs; D004617:Embolism / Q000517:prevention & control; D005260:Female; D008297:Male; D010973:Platelet Adhesiveness; D012826:Silicone Elastomers; D013927:Thrombosis / Q000517:prevention & control; D014684:Venae Cavae
D000418:Albumins; D001672:Biocompatible Materials; D012826:Silicone Elastomers