[Effect of psychostimulants on the relearning by rats of the avoidance direction in a U-shaped labyrinth].
The capacity of rats to relearning the direction of the avoidance in a U-shaped maxe was determined. Four traning sessions--each time in a new direction (to the right, or to the left) of running were conducted. D, 1-amphetamine given in low and medium doses (0.5 and 2 mg/kg) shortened the latent response periods and failed to influence the relearning of the animals. A high dose of the drug (5 mg/kg) led to reduction of the latency of the responses, but at the same time inhibited the reconstruction of the avoidance habit; this distinctly correlated with the intensification of space preference. Caffine (25 and 50 mg/kg) failed to influence the relearning of rats.
D000661:Amphetamine / Q000494:pharmacology*; D000818:Animals; D001362:Avoidance Learning / Q000187:drug effects*; D002110:Caffeine / Q000494:pharmacology*; D005260:Female; D008297:Male; D051381:Rats; D011930:Reaction Time / Q000187:drug effects
D002110:Caffeine; D000661:Amphetamine
Vliianie psikhostimuliatorov na pereobuchenie krys napravleniiu izbeganiia v U-OBRAZNOM LABIRINTE