title: Renal and intrarenal blood flow distribution in swine during severe exercise.
abstract: It is known that a compensatory reduction and diversion of renal flow occurs in severe exercise in humans but not in dogs. We investigated this in miniature swine by measuring changes in total renal blood flow (TRF) and intra-renal blood flow (IRBF) distribution with tracer microspheres (15 +/- 5 mum) at rest and during steady-state exercise at 4.8-7.2 kph and 0% grade, and during severe exercise at 4.8-7.2 kph and 10% grade. We measured heart rate and cardiac output (Q) via implanted probes. TRF was determined as a percent of Q and as ml/100 g per min. IRBF was determined for the outer cortex, inner cortex, outer medulla, and inner medulla. Our results show that renal blood flow is significantly (P less than 0.05) reduced in pigs with exercise. Steady-state exercise reduced flow to about 66% of control and severe exercise reduced renal flow to 30% of control. IRBF was unchanged throughout. These results show that the exercising pig augments blood flow to skeletal muscle by reducing blood flow to kidneys, a response known to occur in man.
mesh_terms: D000818:Animals; D004558:Electric Stimulation; D006439:Hemodynamics; D007668:Kidney / Q000098:blood supply*; D009132:Muscles / Q000098:blood supply; D005082:Physical Exertion; D012039:Regional Blood Flow; D013552:Swine / Q000502:physiology*; D014655:Vascular Resistance