[The antiarrhythmic effects of verapamil in acute myocardial infarction. Considerations on the possible action mechanism (author's transl)].
In 12 patients affected by acute myocardial infarction complicated only by ventricular extrasystoles, verapamil was highly effective in the control of the arrhythmias. This result is in agreement with the experimental finding that ischemia inactivates partially or totally early Na+ inward currents, so that fast fibers become slow fibers. The efficacy of verapamil stresses the importance of these fibers which have acquired a slow response in the genesis of arrhythmias due to acute coronary attacks and opens interesting therapeutical prospects.
D000208:Acute Disease; D000368:Aged; D001145:Arrhythmias, Cardiac / Q000188:drug therapy* / Q000209:etiology; D004341:Drug Evaluation; D006801:Humans; D008875:Middle Aged; D009203:Myocardial Infarction / Q000150:complications*; D014700:Verapamil / Q000009:adverse effects / Q000627:therapeutic use*
D014700:Verapamil
Azione antiaritmica del verapamil nell'infarto miocardico acuto. Considerazioni sul possibile meccanismo d'azione.