title: Critical tests of anthelmintic activity of a paste formulation of thiabendazole in horses.
abstract: Critical tests of the activity on large strongyles, ascarids, mature pinworms, and bots were carried out in 11 horses intraorally treated with a paste formulation of thiabendazole. The dose level of 44 mg/kg was administered to 3 horses, and the dose level of 88 mg/kg to 8 horses. Removals of Strongylus vulgaris and mature Oxyuris equi were 100% at the 2 dose levels, and efficacy against Strongylus edentatus varied from 95 to 99% and 89 to 100% for the 44- and the 88-mg/kg dose levels, respectively. Strongylus equinus was completely removed from the 1 infected horse treated at the dose level of 88 mg/kg. Activity of the smaller dose against Parascaris equorum was 46%, and that of the larger dose varied from 32 to 100%. The drug was inactive on Gasterophilus intestinalis and Gasterophilus nasalis.
mesh_terms: D000284:Administration, Oral; D000818:Animals; D004175:Diptera; D004304:Dosage Forms; D006734:Horse Diseases / Q000188:drug therapy*; D006736:Horses; D009349:Nematode Infections / Q000188:drug therapy / Q000662:veterinary*; D010123:Oxyuriasis / Q000188:drug therapy / Q000662:veterinary; D010272:Parasitic Diseases / Q000188:drug therapy; D010273:Parasitic Diseases, Animal; D013319:Strongyle Infections, Equine / Q000188:drug therapy; D013827:Thiabendazole / Q000008:administration & dosage* / Q000627:therapeutic use
chemical_list: D004304:Dosage Forms; D013827:Thiabendazole