Cellular hypersensitivity in rheumatoid arthritis, ankylosing spondylitis, and anterior nongranulomatous uveitis.
The humoral and cellular responses to normal human ocular and joint tissue antigens were studied in rheumatoid arthritis, ankylosing spondylitis, and anterior non-granulomatous uveitis. No free-circulating autoantibodies could be detected by hemagglutination, immunodiffusion, and immunofluorescence. Uvea-retina, synovial membrane, and articular cartilage antigen preparations inhibited the migration of leukocytes from patients with rheumatoid arthritis. In ankylosing spondylitis inhibition could be induced only by synovial membrane antigens. Patients with anterior nongranulomatous uveitis were hypersensitive to uvea-retina antigens alone.
D001172:Arthritis, Rheumatoid / Q000276:immunology*; D001323:Autoantibodies / Q000032:analysis; D002358:Cartilage, Articular / Q000276:immunology; D002464:Cell Migration Inhibition; D006801:Humans; D006968:Hypersensitivity, Delayed / Q000276:immunology*; D007111:Immunity, Cellular; D007962:Leukocytes / Q000276:immunology; D013167:Spondylitis, Ankylosing / Q000276:immunology*; D013583:Synovial Membrane / Q000276:immunology; D014020:Tissue Extracts / Q000276:immunology; D014602:Uvea / Q000276:immunology; D014605:Uveitis / Q000276:immunology*
D001323:Autoantibodies; D014020:Tissue Extracts