title: Complications following parametrial radiogold treatment for cervical carcinoma.
abstract: Between January 1950 and March 1965, 382 patients with carcinoma of the uterine cervix were treated with parametrial radiogold injections. One hundred and ninety-two patients are known to have survived 5 or more years after the treatment without evidence of recurrence. Major complications with significant morbidity requiring hospitalization or additional surgery was observed in 9.4% of the patients. Parametrial radiogold injection is associated with a high incidence of major lower urinary tract complications, including an increased incidence of ureteral obstruction as a result of radiation fibrosis, Heterogenous distribution of radioactive material with localized areas of heavy irradiation is probably responsible for the development of late major complications.
mesh_terms: D001956:Broad Ligament; D005260:Female; D005767:Gastrointestinal Diseases / Q000209:etiology; D006048:Gold Colloid, Radioactive / Q000008:administration & dosage / Q000009:adverse effects* / Q000627:therapeutic use; D006801:Humans; D007267:Injections; D008923:Missouri; D013997:Time Factors; D014570:Urologic Diseases / Q000209:etiology; D002583:Uterine Cervical Neoplasms / Q000188:drug therapy / Q000401:mortality / Q000532:radiotherapy*
chemical_list: D006048:Gold Colloid, Radioactive