The relative biological effectiveness (RBE) and oxygen enhancement ratio (OER) of neon ions for the EMT6 tumor system.
EMT6 tumors were exposed to neon ions in vivo and in vitro in the plateau and spread-out Bragg peak regions of the beam. The RBE in vivo was 1.7-2.1 in the plateau region and 2.6-2.9 in the Bragg peak; the OER was 2.0 and 1.4, respectively. Neon ions have great potential in the radiotherapy of tumors because of their decreased OER and excellent depth-dose distribution in tissue.
D000818:Animals; D002588:Cesium Radioisotopes / Q000627:therapeutic use*; D004307:Dose-Response Relationship, Radiation; D008325:Mammary Neoplasms, Experimental / Q000532:radiotherapy*; D051379:Mice; D009356:Neon / Q000627:therapeutic use*; D010100:Oxygen; D011879:Radiotherapy Dosage
D002588:Cesium Radioisotopes; D009356:Neon; D010100:Oxygen