Biochemical studies on peptide alkaloids: induction of ion selective mitochondrial swelling.
The effect of frangulanine, a cyclopeptide alkaloid isolated from Hovenia dulcis Thunb., on mitochondrial swelling was studied. Frangulanine induced mitochondrial swelling in 0.15 M KCl solution at the concentration of 6.5 muM. The alkaloid showed ion selectivity on the induction of mitochondrial swelling. Upon addition of frangulanine, mitochondria underwent swelling in 0.15 M KCl or RbCl solution but in neither NaCl nor LiCl solution.
D000470:Alkaloids / Q000494:pharmacology*; D000818:Animals; D002414:Cations, Monovalent; D007476:Ionophores; D008930:Mitochondria, Liver / Q000187:drug effects*; D010456:Peptides, Cyclic / Q000494:pharmacology*; D051381:Rats
D000470:Alkaloids; D002414:Cations, Monovalent; D007476:Ionophores; D010456:Peptides, Cyclic; C015229:frangulanine