Fibrin/fibrinogen degradation products (FDP) in urine and serum after prolonged heavy exercise.
The presence of FDP in the urine, known to be a sensitive indicator of various kidney disorders, was studied in 14 well-trained men participating in a 70-km cross-country ski race. None of the urine samples contained FDP on the day before the race. Immediately after the race, 4 samples contained FDP. High molecular weight FDP were found in 2 of them, whereas 2 others contained low molecular weight products only. 2 days after the race, 1 of these subjects still had FDP in the urine. In addition, 2 newly FDP positives were observed. Serum FDP were slightly elevated in 2 subjects before the race, and in another subject immediately after the race. The presence of urinary FDP did not correlate either with urinary albumin or uromucoid, or with serum FDP. A drop in plasma fibrinogen immediately after the race was noted in all subjects. It is suggested that the present observations may reflect a transient hyperproteolysis (coagulation and fibrinolysis) in the glomerular circulation, including fibrin formation and dissolution, associated with a transient damage of glomerular capillaries.
D000328:Adult; D000419:Albuminuria; D005338:Fibrin Fibrinogen Degradation Products / Q000032:analysis / Q000097:blood / Q000652:urine; D005340:Fibrinogen / Q000378:metabolism; D006801:Humans; D008297:Male; D009088:Mucoproteins / Q000652:urine; D009994:Osmolar Concentration; D005082:Physical Exertion; D012709:Serum Albumin / Q000378:metabolism; D013997:Time Factors
D005338:Fibrin Fibrinogen Degradation Products; D009088:Mucoproteins; D012709:Serum Albumin; D005340:Fibrinogen