Aspermia and recovery of spermatogenesis in cancer patients following incidental gonadal irradiation during treatment: a progress report.
The 11 patients in this study who received incidental gonadal irradiation from clinical therapy all became aspermic within 8-34 weeks following treatment. The estimated gonadal dose was 118-228 rads. Five of these patients have shown recovery of spermatogenesis; 3 of these have reached fertilizable concentrations. Recovery of semen sperm was noted at 44-77 weeks following treatment. The other 2 patients, after 110-176 weeks, have sub-fertile concentrations of semen sperm. Five patients have not been followed for a sufficient length of time to permit recovery to be noted.
D000293:Adolescent; D000328:Adult; D006801:Humans; D007248:Infertility, Male / Q000209:etiology*; D008297:Male; D008875:Middle Aged; D009845:Oligospermia / Q000209:etiology; D011832:Radiation Injuries; D011878:Radiotherapy / Q000009:adverse effects*; D013091:Spermatogenesis / Q000528:radiation effects; D013737:Testis / Q000528:radiation effects