title: Permeability of human chorion laeve to diazepam and meperidine.
abstract: In vitro placental permeability to diazepam (Valium) and meperidine (Demerol) in excess of that measured for antipyrine, suggest that these compounds will diffuse across placental tissue in vivo at a maximal or perfusion-limited rate. Such findings correspond to the high fetal blood levels reported for these substances following maternal administration and indicate that these lipid-soluble analgesics cross this tissue by transcellular as well as extracellular pathways.
mesh_terms: D000618:Aminohippuric Acids / Q000378:metabolism; D000983:Antipyrine / Q000378:metabolism; D002463:Cell Membrane Permeability; D002823:Chorion / Q000378:metabolism*; D003975:Diazepam / Q000032:analysis / Q000378:metabolism*; D004058:Diffusion; D005321:Extraembryonic Membranes / Q000378:metabolism*; D005260:Female; D005312:Fetal Blood / Q000032:analysis; D006801:Humans; D066298:In Vitro Techniques; D008431:Maternal-Fetal Exchange; D008614:Meperidine / Q000032:analysis / Q000378:metabolism*; D010920:Placenta / Q000378:metabolism; D011247:Pregnancy
chemical_list: D000618:Aminohippuric Acids; D008614:Meperidine; D003975:Diazepam; D000983:Antipyrine