Effect of liquid diet on serum protein binding and prednisolone concentrations after oral prednisone.
After prednisone (two 5 mg tablets) was given to each of six normal volunteers with water or with a liquid meal, standard pharmacokinetic parameters of prednisolone metabolism were similar, except that peak serum prednisolone concentrations occurred later after the meal. We conclude that prednisone can be given with a meal without significantly affecting the metabolism of prednisone or prednisolone.
D000284:Administration, Oral; D004032:Diet; D004326:Drinking; D006801:Humans; D008657:Metabolic Clearance Rate; D011239:Prednisolone / Q000097:blood*; D011241:Prednisone / Q000008:administration & dosage* / Q000378:metabolism; D011485:Protein Binding
D011239:Prednisolone; D011241:Prednisone