Estrogen- and progesterone-induced uterine motility of anestrous goats.
Uterine motility was studied in the anestrous goats after a series of estradiol injections was given and after estradiol-plus-progesterone treatment was administered. Estradiol (0.1 mg/kg) given alone by intramuscular route every 6 hours for 4 continuous days produced only a moderate increase in the uterine contractions during treatment, but significantly higher amplitude and frequency of contractions occurred at 2 days after treatment was stopped. The same doses of estradiol administered for a 24-hour period and followed by 4 injections of progesterone (1.0 mg/kg) given intramuscularly once a day produced a moderate response during treatment, but depressed the amplitude and the frequency of contractions after the treatment was stopped. The results indicate that the tissues primed with estrogen produced a stimulatory effect after their estrogen contents diminished. Progesterone, likewise, produced inhibition after a decrease in the progesterone contents of the uterine tissue.
D000780:Anestrus; D000818:Animals; D004958:Estradiol / Q000494:pharmacology*; D004971:Estrus; D005260:Female; D006041:Goats / Q000502:physiology*; D011247:Pregnancy; D011374:Progesterone / Q000494:pharmacology*; D014590:Uterine Contraction / Q000187:drug effects*
D011374:Progesterone; D004958:Estradiol