[The thrombocyte aggregating effect of phosphatidic acids and their lyso-derivatives (DAS)].
In aged plasma or serum phosphatidic and lysophosphatidic acids (DAS) may occur which have been found to induce platelet aggregation in human and feline PRP (platelet rich plasma). Experiments performed on cats demonstrate that the lethal effect frequently following the i.v. injection of these substances into cats with high platelet counts is mediated via massive pulmonary microembolization. It remains to be elucidated whether the in vivo formation of these phospholipids may be of clinical interest.
D000818:Animals; D001049:Apnea / Q000139:chemically induced; D001794:Blood Pressure / Q000187:drug effects; D001919:Bradycardia / Q000139:chemically induced; D002415:Cats; D010712:Phosphatidic Acids / Q000494:pharmacology*; D010713:Phosphatidylcholines / Q000494:pharmacology; D010974:Platelet Aggregation / Q000187:drug effects*
D010712:Phosphatidic Acids; D010713:Phosphatidylcholines
Zur Thrombozyten-aggregierenden Wirkung von Phosphatidsäuren und deren Lyso-Derivaten (DAS).