Potentiating effect of (+)-sotalol and deoxysotalol on prostaglandin-evoked contractions of the isolated rat uterus.
The effect of (+)-sotalol and deoxysotalol on prostaglandin (PGF2a and 15-methyl PGF2alpha)-evoked contractions was studied using the isolated rat uterus. After control responses to prostaglandins had been obtained the uterus was exposed to the nutrient fluid containing 10 microgram/ml of (+)-sotalol, deoxysotalol or (--) sotalol. 30 min later the responses to prostaglandins were again recorded. Both (+)-sotalol and deoxysotalol potentiated PGF2alpha as well as 15-methyl PGF2alpha-induced contractions. (--)-Sotalol did not potentiate the PGF2alpha-evoked contractions of the isolated rat uterus. The possible clinical significance of the results is discussed.
D000818:Animals; D004357:Drug Synergism; D005260:Female; D066298:In Vitro Techniques; D011461:Prostaglandins F, Synthetic / Q000494:pharmacology*; D051381:Rats; D013015:Sotalol / Q000031:analogs & derivatives* / Q000494:pharmacology*; D013237:Stereoisomerism; D014590:Uterine Contraction / Q000187:drug effects*
D011461:Prostaglandins F, Synthetic; D013015:Sotalol