Adrenergic compounds and the respiratory tract. A physiological and electron-microscopical study.
Studies were undertaken to determine the effect of several adrenergic compounds on ciliary activity and on the micromorphology of the goblet cells and mucous glands. All the substances tested, L-adrenaline, d-L-ephedrine, N-isopropyl-noradrenaline and 1-(4-amino-3, 5-dichlorphenyl)-2-tert-butyl-aminoethanol-HCl increased ciliary activity, but have markedly different effects on goblet cells, mucous glands and on the quality of the produced mucus.
D000818:Animals; D001980:Bronchi / Q000187:drug effects* / Q000648:ultrastructure; D002415:Cats; D002923:Cilia / Q000187:drug effects* / Q000502:physiology; D004809:Ephedrine / Q000494:pharmacology; D004837:Epinephrine / Q000494:pharmacology; D005260:Female; D008297:Male; D009093:Mucus / Q000187:drug effects* / Q000378:metabolism; D009638:Norepinephrine / Q000031:analogs & derivatives / Q000494:pharmacology; D051381:Rats; D013566:Sympathomimetics / Q000494:pharmacology*; D014132:Trachea / Q000187:drug effects* / Q000648:ultrastructure
D013566:Sympathomimetics; D004809:Ephedrine; D009638:Norepinephrine; D004837:Epinephrine