Antibiotic DE-3936, a polyether antibiotic identical with lonomycin. Taxonomy, fermentation, isolation and characterization.
Antibiotic DE-3936 was isolated from the fermentation broth of a streptomycete No. 9735-1, which is identified as a strain of Streptomyces hygroscopicus. The antibiotic is a hydrophobic compound having the molecular formula of of C44H75O14Na and is  active against Gram-positive bacteria, mycobacteria, mycoplasma and protozoa, especially coccidia. Its chemical and biological properties indicate that antibiotic DE-3936 belongs to the group of polyether antibiotics and is identical with lonomycin.
D000818:Animals; D000900:Anti-Bacterial Agents / Q000032:analysis / Q000096:biosynthesis / Q000494:pharmacology; D001419:Bacteria / Q000187:drug effects; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D003460:Crystallization; D004987:Ethers / Q000032:analysis / Q000096:biosynthesis / Q000494:pharmacology; D005285:Fermentation; D005658:Fungi / Q000187:drug effects; D051379:Mice; D009550:Nigericin / Q000031:analogs & derivatives; D013302:Streptomyces / Q000378:metabolism
D000900:Anti-Bacterial Agents; D004987:Ethers; C012410:lonomycin; D009550:Nigericin