title: Artificial donor insemination with frozen human semen.
abstract: This study describes the experience with artificial donor insemination (AID) using frozen semen in 227 women who began therapy in 1974 and were followed until March 31, 1976. Ninety-one women (40%) conceived during this period. Sixty-five women (37.9%) failed to continue treatment after three or fewer cycles; follow-up on these patients was incomplete and it is presumed that most did not conceive. The cumulative pregnancy rate was 56.5% among women who persisted in AID for four or more cycles. Additional causes for infertility were found in 53 women. Excluding these, the pregnancy rate was 67.4% for apparently fertile women who had had four or more cycles of AID. Fifty-eight per cent of conceptions occurred within the first three cycles and eighty-five per cent within the first six cycles. The pregnancy rate was not significantly affected by age, occupation, cigarette smoking, or prior fertility. The large number of dropouts after a few cycles of AID suggests a need for intensive and continuous educational, emotional, and psychologic support.
mesh_terms: D000293:Adolescent; D000328:Adult; D005260:Female; D005615:Freezing; D006801:Humans; D007315:Insemination, Artificial / Q000523:psychology; D007316:Insemination, Artificial, Heterologous / Q000523:psychology; D010352:Patient Dropouts; D011247:Pregnancy; D012662:Semen Preservation; D013315:Stress, Psychological