title: The genetic instabilities of the mating type locus in fission yeast.
abstract: Certain genetic instabilities of the "mating type locus" in the yeast Schizosaccharomyces pombe are interpreted in terms of transposition: Homothallic strains are characterized by two adjacent mating type genes (mat1-mat2+) with sexually complementary functions. One of these genes (mat2+) is able to duplicate itself, and the duplicated copy maps at the position of mat1-. The former function of mat1-is lost (owing to insertion), and only becomes reactivated when the inserted sequence (mat1+) is again excised. Analyses of analogous instabilities expressed by the partially defective mutation mat2+ -B102 have substantiated this transposition scheme. Homothallism is acribed to alternate and mutually exclusive activation of mat1- or mat2+ genes.
mesh_terms: D000483:Alleles; D001203:Ascomycota; D008938:Mitosis; D008954:Models, Biological; D009154:Mutation; D010641:Phenotype; D011995:Recombination, Genetic; D012568:Schizosaccharomyces