Modulation of C3b hemolytic activity by a plasma protein distinct from C3b inactivator.
A human plasma protein binds to cell-bound C3b, the major cleavage product of the third component of complement. Consequent upon this binding, C3b no longer functions in either the classical or alternative pathways. This C3b inhibitory activity is a property of a protein previously designated beta 1H on the basis of its electrophoretic mobility.
D001798:Blood Proteins / Q000378:metabolism* / Q000494:pharmacology; D003176:Complement C3 / Q000378:metabolism* / Q000494:pharmacology; D003181:Complement C4 / Q000378:metabolism; D003165:Complement System Proteins / Q000378:metabolism*; D006461:Hemolysis / Q000187:drug effects*; D006801:Humans; D011485:Protein Binding
D001798:Blood Proteins; D003176:Complement C3; D003181:Complement C4; D003165:Complement System Proteins