title: Effect of low-dose propantheline on food-stimulated gastric acid secretion: comparison with an "optimal effective dose" and interaction with cimetidine.
abstract: We evaluated the widely held notion that anticholinergic drugs must be used in near toxic doses to inhibit gastric acid secretion effectively. Nine patients with duodenal ulcer were studied after a low dose (15 mg) and after a near toxic dose (averaging 48 mg) of the anticholinergic, propantheline. Mean (+/- S.E.) inhibition of food-stimulated acid secretion was identical with the two doses of propantheline: 29 +/- 10 and 29 +/- 11 per cent, respectively. In addition, when 15 mg of propantheline was combined with the histamine H2-receptor antagonist, cimetidine, acid secretion was suppressed to a greater degree than with either drug alone. A low dose of propantheline is as effective as a near toxic dose in suppressing food-stimulated acid secretion and augments the inhibitory effect of cimetidine.
mesh_terms: D000328:Adult; D002927:Cimetidine / Q000008:administration & dosage* / Q000494:pharmacology / Q000627:therapeutic use; D004341:Drug Evaluation; D004359:Drug Therapy, Combination; D004381:Duodenal Ulcer / Q000188:drug therapy*; D005502:Food; D005750:Gastric Juice / Q000378:metabolism*; D005755:Gastrins / Q000097:blood; D006146:Guanidines / Q000008:administration & dosage*; D006801:Humans; D008875:Middle Aged; D011413:Propantheline / Q000008:administration & dosage* / Q000494:pharmacology / Q000627:therapeutic use
chemical_list: D005755:Gastrins; D006146:Guanidines; D011413:Propantheline; D002927:Cimetidine