Brain and spinal cord lesions in the newborn rat.
Previous studies involving the induction of central nervous system lesions in animals have required complex, expensive equipment including sterotaxis and an operating microscope. This study describes a technique for producing telencephalic (forebrain) lesions in the developing rat by the use of copper wire. In addition, a nonvisual method of producing spinal cord transections in the young rat is discussed. Both techniques have a high succes rate and minimal mortality.
D000818:Animals; D000831:Animals, Newborn; D001927:Brain Diseases / Q000209:etiology / Q000473:pathology / Q000662:veterinary*; D051381:Rats; D012376:Rodent Diseases / Q000209:etiology* / Q000473:pathology; D013116:Spinal Cord / Q000473:pathology; D013118:Spinal Cord Diseases / Q000209:etiology / Q000473:pathology / Q000662:veterinary*; D013687:Telencephalon / Q000473:pathology