title: HLA antigens in Japanese populations.
abstract: HLA antigens in 841 healthy, unrelated Japanese from nine widely separated geographic localities were studied. The five most common antigens observed in order of decreasing frequency were for the HLA-A locus: HLA-A9, A2, A10, AW32 and A11; and for the HLA-B locus: HLA-'B5' (= HLA-B5+B17), BW40, B12, B14 and B8. The allelic frequency of undetected antigens of the HLA-A locus was .14-.37, and that of the HLA-B locus, .32-.67, indicating that there were serological difficulties in typing for Japanese antigens using antisera from Caucasians. Marked gene frequency clines were observed for HLA-A9 and HLA-A2 from south (Okinawa) to north (Nagoya). Two haplotypes, HLA-A9, B5 and HLA-A10, BW40 were shown to be in linkage disequilibrium in four of the nine subpopulations.
mesh_terms: D000483:Alleles; D044466:Asian People; D005260:Female; D005787:Gene Frequency; D006680:HLA Antigens; D006649:Histocompatibility Antigens; D006801:Humans; D007564:Japan; D008297:Male
chemical_list: D006680:HLA Antigens; D006649:Histocompatibility Antigens