Acute intravenous infusion in freely moving rats through the sagittal and transverse sinuses.
A technique is described which allows drugs to be injected intravenously using the junction of the sagittal and transverse sinuses as the point of entry into the venous system. The procedure is rapid and uses conventional stereotaxic techniques. Subsequent restraint of movement during drug infusion is minimal. Using this method, 15 mug/kg d-lysergic acid diethylamide produced an increase in acoustic startle amplitide within about 1-2 min which lasted for about 25 min.
D000161:Acoustic Stimulation; D000818:Animals; D003392:Cranial Sinuses; D007274:Injections, Intraperitoneal; D007275:Injections, Intravenous / Q000379:methods*; D008238:Lysergic Acid Diethylamide / Q000008:administration & dosage / Q000494:pharmacology; D008297:Male; D051381:Rats; D013216:Reflex, Startle / Q000187:drug effects; D013997:Time Factors
D008238:Lysergic Acid Diethylamide