title: The relationship between measles virus infection and subacute sclerosing panencephalitis (SSPE).
abstract: On theoretical grounds we propose that the essential step in the development of subacute sclerosing panencephalitis (SSPE) after measles virus infection involves a reverse transcriptase-mediated change to a DNA form, probably brought about by co-infection with a leukovirus at a critical point in time. We further suggest that this new DNA then replicates either as the core of a new slow virus or as a membrane-attached viroid exhibiting a form of non-structural integration with host cell DNA resembling that found with the herpes viruses.
mesh_terms: D004261:DNA Replication; D004279:DNA, Viral / Q000096:biosynthesis; D006801:Humans; D008457:Measles / Q000150:complications*; D008459:Measles virus / Q000472:pathogenicity*; D008954:Models, Biological; D012367:RNA, Viral / Q000096:biosynthesis; D013344:Subacute Sclerosing Panencephalitis / Q000382:microbiology*; D014779:Virus Replication
chemical_list: D004279:DNA, Viral; D012367:RNA, Viral