Effects of stroma-free haemoglobin solution on the blood-clotting system in dogs.
The effect of transfusions of 500 ml of 5-6% stroma-free haemoglobin solutions on the blood-clotting system of dogs was studied. Slight lowering of the fibrinogen level and of the activity of clotting factors V, VII, VIII, IX and X was observed, together with some prolongation of the thrombin time. In vitro investigations indicate that prolongation of the thrombin time may depend on disturbed polymerization of fibrin monomers. After transfusion of stroma-free haemoglobin preparation, no signs of haemorrhagic diathesis were observed.
D000818:Animals; D001777:Blood Coagulation; D001803:Blood Transfusion; D004285:Dogs; D005164:Factor IX / Q000032:analysis; D005165:Factor V / Q000032:analysis; D005167:Factor VII / Q000032:analysis; D005169:Factor VIII / Q000032:analysis; D005170:Factor X / Q000032:analysis; D005338:Fibrin Fibrinogen Degradation Products / Q000097:blood; D005340:Fibrinogen / Q000032:analysis; D006454:Hemoglobins; D006474:Hemorrhagic Disorders; D010952:Plasma Substitutes; D011517:Prothrombin Time; D013997:Time Factors
D005338:Fibrin Fibrinogen Degradation Products; D006454:Hemoglobins; D010952:Plasma Substitutes; D005165:Factor V; D005167:Factor VII; D005169:Factor VIII; D005164:Factor IX; D005170:Factor X; D005340:Fibrinogen