The intestinal phase of gastric secretion. Response to liver extract infusion into the proximal jejunum of healthy human subjects.
A Levine tube was placed under radiological control in the stomach, and a thin polyethylene tube in the proximal jejunum of 6 healthy volunteers. The stomach and proximal part of jejunum were perfused for 2 hours with 1% acetylcholine, 20% meat extract (Bovril), and 15% liver extract (LE) alone and in combination with simultaneous infusion of different doses of exogenous pentagastrin intravenously. A significant increase in serum gastrin concentration was found with antral perfusion of LE only, whereas perfusion of the proximal jejunum did not change the basal level of the serum gastrin concentration. No change from control values was observed in gastric acid, and pepsin output on perfusing proximal jejunum with LE alone, or in combination with pentagastrin. Reflux to the stomach varied between 0-1.4%, as determined by addition of radioactive B12 to the perfusates. The experiments showed that gastrin was released from the antrum of the stomach by perfusion with 15 per cent LE, but not from the jejunum under the present experimental conditions. In the present experiments Bovril and acetylcholine perfusions did not cause significant responses from the antrum or from the proximal jejunum.
D000109:Acetylcholine / Q000008:administration & dosage / Q000494:pharmacology; D005750:Gastric Juice / Q000032:analysis / Q000378:metabolism*; D005755:Gastrins / Q000097:blood; D006801:Humans; D007275:Injections, Intravenous; D007583:Jejunum / Q000502:physiology*; D008110:Liver Extracts / Q000008:administration & dosage / Q000494:pharmacology*; D010418:Pentagastrin / Q000008:administration & dosage / Q000494:pharmacology; D010477:Perfusion; D012636:Secretory Rate
D005755:Gastrins; D008110:Liver Extracts; D010418:Pentagastrin; D000109:Acetylcholine