title: Studies of respiratory morbidity in rubber workers. Part IV. Respiratory morbidity in talc workers.
abstract: Pulmonary function tests, chest x-rays, and respiratory questionnaires were administered to eighty talc workers and 189 non-exposed rubber workers from three rubber tire manufacturing plants. The talc workers, who were exposed to talc at levels below the current threshold limit value (TLV) of 20 mppcf for nonfibrous talc, had a statistically significantly greater prevalence of productive cough and of positive criteria for chronic obstructive lung disease (COLD) than did the control workers. The talc workers with more than 10 years of exposure had significantly decreased residual FEV 1.0. Multiple regression analysis of FEV 1.0 in the talc workers estimated that each year of exposure to talc dust reduced the FEV 1.0 by 26 ml. Talc workers had a clear increase in respiratory morbidity, despite the absence of chest roentgenographic changes. Based on this study, a safe exposure level for talc appears to be 25 mg/m3 as a time-weighted average.
mesh_terms: D001991:Bronchitis / Q000139:chemically induced; D002908:Chronic Disease; D004781:Environmental Exposure; D005541:Forced Expiratory Volume; D006801:Humans; D008173:Lung Diseases, Obstructive / Q000139:chemically induced; D008452:Maximum Allowable Concentration; D009784:Occupational Diseases / Q000139:chemically induced* / Q000000981:diagnostic imaging / Q000453:epidemiology; D011859:Radiography; D012044:Regression Analysis; D012129:Respiratory Function Tests; D012140:Respiratory Tract Diseases / Q000139:chemically induced* / Q000000981:diagnostic imaging / Q000453:epidemiology; D012907:Smoking / Q000150:complications; D013627:Talc / Q000009:adverse effects*; D014797:Vital Capacity
chemical_list: D013627:Talc