Isolations of a cartilage factor that inhibits tumor neovascularization.
A cartilage fraction isolated by guanidine extraction and purified by affinity chromatography inhibits tumor-induced vascular proliferation and consequently restricts tumor growth. This fraction contains several different proteins; the major one has a molecular weight of about 16,000. The fraction strongly inhibits protease activity.
D002277:Carcinoma / Q000098:blood supply; D002356:Cartilage / Q000032:analysis; D003315:Cornea; D004791:Enzyme Inhibitors / Q000302:isolation & purification; D009368:Neoplasm Transplantation; D009374:Neoplasms, Experimental / Q000098:blood supply*; D011480:Protease Inhibitors
D004791:Enzyme Inhibitors; D011480:Protease Inhibitors