title: [Effect of podophyllin resine on the mobility of langerhans cells (author's transl)].
abstract: The application of an alcoholic solution of podophyllin resin at concentrations above 10 p. 100 on guinea-pig udders, produces in epidemic Langerhans cells the same cytological effects as those by colchicine and vinca alcaloid in culture cells. The Langerhans cells are a suitable experimental model in vivo because of its easy ultrastructural identification, its migratory character and its preferential localization in epidermis.
mesh_terms: D000818:Animals; D002465:Cell Movement / Q000187:drug effects*; D002478:Cells, Cultured; D003078:Colchicine / Q000494:pharmacology; D003593:Cytoplasm / Q000648:ultrastructure; D004721:Endoplasmic Reticulum / Q000648:ultrastructure; D006168:Guinea Pigs; D066298:In Vitro Techniques; D007801:Langerhans Cells / Q000187:drug effects* / Q000648:ultrastructure; D011033:Podophyllin / Q000494:pharmacology*; D012116:Resins, Plant; D013268:Stimulation, Chemical; D014748:Vinca Alkaloids / Q000494:pharmacology
chemical_list: D012116:Resins, Plant; D014748:Vinca Alkaloids; D011033:Podophyllin; D003078:Colchicine
vernacular_title: Effet de la résine de podophylline sur la mobilité des cellules de Langerhans.