[Condensed and dispersed chromatin in the nuclei of thyroid follicular cells under normal conditions and following thyrotropic stimulation].
The author examined the changes in the nuclear size, in its form and optical density as well as the changes in the condensed and dispersed chromatin of the follicular cells of the thyroid gland after thyroid stimulation by means of the method of scanning cytophotometry. He found that after a 20-day treatment of the animals with methythyouracyl-an agent, which blocks thyroid hormonal synthesis and in this way raised the level of the thyreothropic hormone in circulation, the size of the cell nuclei was increased and at the same time its concentration of DNA was reduced. The amount of the particles of the condensed chromatin after thyreotropic stimulation diminished, but the integral space remained unchanged and the area of the dispersed chromatine was mainly increased. The obtained data are discussed in view of the possibilities of the scanning cytophotometry for evaluation of the functional activity of the cell.
D000818:Animals; D002467:Cell Nucleus / Q000378:metabolism / Q000648:ultrastructure*; D002843:Chromatin / Q000648:ultrastructure*; D004247:DNA / Q000378:metabolism; D005260:Female; D006651:Histocytochemistry; D008779:Methylthiouracil / Q000494:pharmacology; D051381:Rats; D013961:Thyroid Gland / Q000378:metabolism / Q000648:ultrastructure*; D013972:Thyrotropin / Q000502:physiology*
D002843:Chromatin; D013972:Thyrotropin; D004247:DNA; D008779:Methylthiouracil
Kondenziran i dispergiran khromatin v iadroto na folikulnite kletki na shchitovidnata zhleza pri norma i tireotropna stimulatsiia.