title: The effect of nerve growth factor and limb regeneration on the spinal and sympathetic ganglia of Triturus.
abstract: In Triturus administration of NGF causes hypertrophy of neuronal perikarya of third dorsal root ganglia and post-subclavian sympathetic ganglia. Two classes of neurons were characterized cytologically in the third dorsal root ganglia. Some evidence is presented which indicates that Class I neurons respond more vigorously to NGF. It is suggested that Class I neurons are similar to the medio-dorsal neuroblasts of chick embryos in their response to NGF. Forelimb amputation did not cause neuronal hypertrophy in either third dorsal root ganglia or post-subclavian sympathetic ganglia. The incorporation of (3H)-uridine increases to a highly significant extent in third dorsal root ganglia following NGF treatment or limb amputation. When NGF treatment and limb amputation were combined, no further increase in (3H)-uridine incorporation was noted. This suggests that RNA synthesis is maximally stimulated by either NGF treatment alone or limb amputation alone.
mesh_terms: D000671:Amputation, Surgical; D000818:Animals; D005552:Forelimb / Q000502:physiology; D005725:Ganglia, Autonomic / Q000187:drug effects* / Q000254:growth & development; D005727:Ganglia, Spinal / Q000187:drug effects* / Q000254:growth & development; D009414:Nerve Growth Factors / Q000494:pharmacology*; D009474:Neurons / Q000187:drug effects; D012038:Regeneration; D014319:Triturus
chemical_list: D009414:Nerve Growth Factors