[Adhesive properties of the upper surface of fibroblasts and epithelium in cultures].
Adhesive properties of the upper surface of cultured normal and neoplastic epithelial cells and of fibroblasts were studied. It was shown that the attachment of prelabeled homo- and heterologous cells introduced into epithelial sheets were very low as compared with the free substratum and dense cultures of fibroblasts. The upper surface of cells of cultured anaplastic hepatoma 22a was adhesive for prelabeled cells. Morphological characteristics of the studied cultures were compared. It was found that low adhesiveness of the upper surface of epithelial sheets correlated with the formation of firm intercellular contacts which remained unbroken during migration into the wound. It is suggested that when epithelial cells make contacts with each other, their surface is subdivided into two types of regions: areas of low adhesiveness (the upper surface), and those of firm intercellular contacts. This may cause the formation of monolayer epithelial sheet.
D002448:Cell Adhesion; D002478:Cells, Cultured; D004848:Epithelium; D005347:Fibroblasts; D009374:Neoplasms, Experimental
Adgezivnye svoĭstva verkhneĭ poverkhnosti fibroblastov i épiteliia v kul'turakh