Ganglioside pattern and neuraminic acid content of human gastric and colonic carcinoma.
Twenty-five human gastric and 11 human colonic adenocarcinomas were analysed for their ganglioside pattern and for their content of lipid-bound and protein-bound neuraminic acid. In most carcinomas the content of both lipid-bound and protein-bound neuraminic acid was increased by an average of four- and two-fold, respectively. The ganglioside pattern of all the carcinomas resembled that of normal tissue. In six gastric carcinomas the content of lipid-bound neuraminic acid and the ratio of lipid-bound neuraminic acid to protein-bound neuraminic acid (L/P ratio) were lower than those of normal gastric mucosa. These carcinomas were significantly larger than the rest of the tumours.
D000230:Adenocarcinoma / Q000378:metabolism*; D003110:Colonic Neoplasms / Q000378:metabolism*; D005732:Gangliosides / Q000378:metabolism*; D006801:Humans; D009363:Neoplasm Proteins / Q000378:metabolism; D012794:Sialic Acids / Q000378:metabolism*; D013274:Stomach Neoplasms / Q000378:metabolism*
D005732:Gangliosides; D009363:Neoplasm Proteins; D012794:Sialic Acids