The effect of lithium chloride on the activity of some psychotropic drugs.
LiCl administered for 4 days enhances amphetamine-induced locomotor stimulation, increases amphetamine toxicity in aggregated mice but does not affect amphetamine stereotypy. Administered together with nialamide, LiCl increase locomotor activity of mice and rats. The administration of this compound together with reserpine reverses central effects of its action (hypothermia, decreased motility, enhancement of hexobarbital activity).
D000662:Amphetamines / Q000494:pharmacology / Q000633:toxicity; D000818:Animals; D001831:Body Temperature / Q000187:drug effects; D004347:Drug Interactions; D005260:Female; D006591:Hexobarbital / Q000494:pharmacology; D006801:Humans; D008094:Lithium / Q000494:pharmacology*; D008297:Male; D051379:Mice; D009043:Motor Activity / Q000187:drug effects; D009526:Nialamide / Q000494:pharmacology; D011619:Psychotropic Drugs / Q000494:pharmacology*; D051381:Rats; D012110:Reserpine / Q000494:pharmacology; D013239:Stereotyped Behavior / Q000187:drug effects
D000662:Amphetamines; D011619:Psychotropic Drugs; D012110:Reserpine; D008094:Lithium; D006591:Hexobarbital; D009526:Nialamide