72-hr canine kidney preservation without continuous perfusion.
A new flushing solution consisting of electrolytes and mannitol has provided successful 3 day canine kidney preservation evidenced by immediate life-supporting renal function. In our experiments the solutions described by Sacks and Collins have failed to achieve this prolonged renal storage but have been successful in storing canine kidneys for 2 days. This relatively simple new hypertonic solution does not require additives and has been successfully used in clinical renal transplantation.
D000818:Animals; D002951:Citrates; D004285:Dogs; D005260:Female; D007668:Kidney; D008297:Male; D009926:Organ Preservation / Q000379:methods*; D010477:Perfusion; D012996:Solutions; D013997:Time Factors; D014021:Tissue Preservation / Q000379:methods*
D002951:Citrates; D012996:Solutions