[In vivo and in vitro cytospectrophotometric studies of DNA in the cells of human neuroectrodermal brain tumors].
A rather distinct correlation in the content and distribution of DNA with the grade of malignancy was estabilished for the following series: normal astrocytes, and oligodendrocytes, typical astrocyfomas and oligodendrogliomas atypical astrocytomas and oligodendrogliomas. For glioblastomas this correlation is impaired, because the polymorphic variant of glioblastoma is characterized by particularly great disturbances in the content and distribution of DNA in the form of polyploidy and aneuploidy which, in this case, reflects not only the grade of malignancy, but also a pronounced polymorphism of tumour cells. The content of DNA in rapidly growing malignant tumours is not only an expressions of real deviation to the side of polyploidy and the mitotic cycle. In neuroectodermal tumours growing in the condition of cell culture, the similar regularity was observed, although the phenomena of aneuploidy were more distinctly expressed in the majority of tumours.
D000782:Aneuploidy; D001254:Astrocytoma / Q000378:metabolism; D001932:Brain Neoplasms / Q000235:genetics / Q000378:metabolism*; D002478:Cells, Cultured; D004273:DNA, Neoplasm / Q000378:metabolism*; D004806:Ependymoma / Q000378:metabolism; D006651:Histocytochemistry; D006801:Humans; D008527:Medulloblastoma / Q000378:metabolism; D009837:Oligodendroglioma / Q000378:metabolism
D004273:DNA, Neoplasm
Tsitospektrofotometricheskoe izuchenie DNK v kletkakh neĭroéktodermal'nykh opukholeĭ golovnogo mozga cheloveka in vivo i in vitro