Prednisolone bioavailability in the dog.
With a fasted dog as an animal model, the bioavailability and pharmacokinetics of prednisolone were studied following rapid intravenous injection and oral dosing of a prednisolone sodium phosphate solution and also following oral doses of prednisolone as tablets and a slurry. Hydrolysis of the phosphate ester to prednisolone in the body is extremely rapid and complete, thus permitting accurate calculation of the distribution volume of prednisolone. Enteral absorption of prednisolone from a slurry is superior to that from prednisolone tablets and from a prednisolone sodium phosphate solution. Reduced absorption from tablets, compared to the slurry, is probably due to tablet disintegration characteristics; reduced absorption from the solution is probably due to poor membrane permeability of the ionized drug. Information obtained from a single animal may indicate the need for expanded studies in humans.
D000284:Administration, Oral; D000818:Animals; D001682:Biological Availability; D004285:Dogs; D004305:Dose-Response Relationship, Drug; D007275:Injections, Intravenous; D007700:Kinetics; D008297:Male; D011239:Prednisolone / Q000008:administration & dosage / Q000378:metabolism*; D012996:Solutions; D013535:Suspensions; D013607:Tablets
D012996:Solutions; D013535:Suspensions; D013607:Tablets; D011239:Prednisolone