Enhanced efficacy of amphotericin B and rifampicin combined in treatment of murine histoplasmosis and blastomycosis.
Amphotericin B in combination with rifampicin was more effective in the treatment of murine histoplasmosis and blastomycosis than either agent alone. The increased therapeutic effects were not accompanied by an increase in toxicity.
D000666:Amphotericin B / Q000008:administration & dosage / Q000627:therapeutic use*; D000818:Animals; D001759:Blastomycosis / Q000188:drug therapy* / Q000401:mortality; D004305:Dose-Response Relationship, Drug; D004359:Drug Therapy, Combination; D005260:Female; D006660:Histoplasmosis / Q000188:drug therapy* / Q000401:mortality; D051379:Mice; D012293:Rifampin / Q000008:administration & dosage / Q000627:therapeutic use*
D000666:Amphotericin B; D012293:Rifampin