Regression of a hamster melanoma with intralesional Corynebacterium granulosum.
The present study was undertaken to compare the antitumour effects of intralesionally administered Corynebacterium granulosum, Corynebacterium parvum, BCG and saline on a hamster melanoma. Forty-eight golden hamsters were inoculated subcutaneously with Forthers melanotic melanoma no. 1. Twenty-four animals bore palpable tumours which were excised. No non-excised group animal showed primary tumour regression. In the excised group, the tumours generally recurred at the excision site in the C. parvum, BCG and saline-treated animals. By contrast, the incidence of recurrence was significantly reduced by intralesional injections of C. granulosum.
D000818:Animals; D001500:BCG Vaccine / Q000627:therapeutic use; D003352:Corynebacterium / Q000276:immunology*; D006224:Cricetinae; D005260:Female; D008175:Lung Neoplasms / Q000517:prevention & control; D008545:Melanoma / Q000276:immunology / Q000601:surgery / Q000628:therapy*; D009362:Neoplasm Metastasis; D009364:Neoplasm Recurrence, Local; D009374:Neoplasms, Experimental / Q000601:surgery / Q000628:therapy; D011425:Propionibacterium acnes / Q000276:immunology
D001500:BCG Vaccine