Activated charcoal-carboxymethylcellulose gel formulation as an antidotal agent for orally ingested aspirin.
The in vivo effect on aspirin absorption of a potentially more palatable form of activated charcoal was compared to that of a simple aqueous slurry of activated charcoal. The experimental formulation consisted of 20.0 g of activated charcoal, 2.25 g of carboxymethylcellulose (CMC) and 42.8 ml of water; it was tested with and without chocolate syrup as a flavoring agent added just prior to administration. Six subjects were treated in crossover fashion following an aspirin dose of 972 mg. Total urinary excretion of salicylate was measured over 48 hours. Although all three treatments appeared to be effective in reducing the rate and extent of aspirin absorption, the slurry was significantly more effective in reducing the total amount absorbed than the charcoal-CMC gel with chocolate syrup. The slight difference in effectiveness between the gel formulation with and without the chocolate syrup was not significant.
D000328:Adult; D000931:Antidotes / Q000494:pharmacology*; D001241:Aspirin / Q000378:metabolism* / Q000652:urine; D002266:Carboxymethylcellulose Sodium / Q000494:pharmacology*; D002606:Charcoal / Q000494:pharmacology; D003864:Depression, Chemical; D004338:Drug Combinations; D005782:Gels; D006801:Humans; D007408:Intestinal Absorption / Q000187:drug effects; D008297:Male; D008747:Methylcellulose / Q000031:analogs & derivatives*; D013997:Time Factors
D000931:Antidotes; D004338:Drug Combinations; D005782:Gels; D002606:Charcoal; D008747:Methylcellulose; D002266:Carboxymethylcellulose Sodium; D001241:Aspirin