Secretion of gastrin and calcitonin after ingestion of meat extract in patients with peptic ulcer.
Serum gastrin and calcitonin were determined after administration of meat extract to patients with peptic ulcer in order to investigate what role gastrin and calcitionin are playing in peptic ulcer. Serum gastrin levels were elevated after ingestion of meat extract in 9 out of 11 patients with peptic ulcer. Serum calcitonin (CT) levels were elevated rather gradually in 7 subjects. It was suggested that increased endogenous gastrin levels may have stimulated the release of CT. When salmon calcitonin (SCT) was admininstered intravenously at a dose of 100 MRCu before administration of meat extract, the rise of gastrin and CT was suppressed in 67% of cases as to gastrin and in 43% as to CT.
D000328:Adult; D000368:Aged; D000818:Animals; D002116:Calcitonin / Q000097:blood / Q000378:metabolism* / Q000494:pharmacology; D004435:Eating; D005755:Gastrins / Q000097:blood / Q000378:metabolism*; D006801:Humans; D008460:Meat; D008875:Middle Aged; D010437:Peptic Ulcer / Q000097:blood / Q000503:physiopathology*; D012474:Salmon
D005755:Gastrins; D002116:Calcitonin