The endogenous--neurotic distinction as a predictor of response to antidepressant drugs.
An inverse factor analysis of 880 depressed inpatients on 33 endogenous-neurotic variables yielded four patient types. Type 3 resembled the endogenous depressions and Type 2 the neurotic depressions. Type 3 patients responded well to both imipramine and chlorpromazine and did poorly on a placebo. Type 2 patients showed the greatest overall improvement at three weeks irrespective of treatment received, including a placebo.
D000275:Adjustment Disorders / Q000188:drug therapy; D000293:Adolescent; D000328:Adult; D000368:Aged; D000928:Antidepressive Agents / Q000627:therapeutic use*; D001007:Anxiety / Q000188:drug therapy; D002746:Chlorpromazine / Q000627:therapeutic use; D003863:Depression / Q000188:drug therapy*; D003975:Diazepam / Q000627:therapeutic use; D005260:Female; D006801:Humans; D007099:Imipramine / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged; D010624:Phenelzine / Q000627:therapeutic use; D010919:Placebos; D011379:Prognosis; D011569:Psychiatric Status Rating Scales; D011618:Psychotic Disorders / Q000188:drug therapy; D012647:Self-Assessment; D012744:Sex Ratio; D013997:Time Factors
D000928:Antidepressive Agents; D010919:Placebos; D010624:Phenelzine; D007099:Imipramine; D003975:Diazepam; D002746:Chlorpromazine