[The effect of extracts from Fallopian tube tissues, uterine fibromas and uterine adenocarcinomas on the growth and capacity for cell division of a human cell line].
Effects of the extracts prepared from tissues of fallopian tubes, uterine fibroid and uterine adenocarcinoma on mitotic activity and amitotic division in culture Tg33 were studied. Extracts with two protein concentrations, 25 and 100 mkg/ml, resp., were used. Differences were found between effects of extracts from malignant tissue and those of histologically unchanged fallopian tube extracts, and also the extract from tissues of uterine fibroid. The extracts from fallopian tubes removed during operation of the ovarian cyst and uterine fibroid (protein concentration 25 and 100 mkg/ml), and the extract of uterine fibroid (100 mkg/ml) caused the increase in mitotic activity. The extract from malignant tissues of adenocarcinoma (protein concentration 25 mkg/ml) and fallopian tubes (25 and 100 mkg/ml) caused no increase in the number of mitoses. The extract from tissues of uterine adenocarcinoma (protein concentration 100 mkg/ml) inhibited the number of mitoses in the culture. The above extracts effecting Tg33 cells caused the increase in the number of amitoses. The number of pathological mitoses did not increase under the influence of all the tested extracts.
D000230:Adenocarcinoma; D002455:Cell Division / Q000187:drug effects*; D002460:Cell Line; D005187:Fallopian Tubes; D005260:Female; D006801:Humans; D007889:Leiomyoma; D008938:Mitosis / Q000187:drug effects*; D014020:Tissue Extracts / Q000494:pharmacology*; D014594:Uterine Neoplasms
D014020:Tissue Extracts
Vliianie ékstraktov iz tkaneĭ fallopievykh trub, fibromy matki i adenokartsinomy matki na rost i sposoby kletochnogo deleniia linii kletok cheloveka