Alpha-and beta-halomorphides: stereochemistry, analgesic potency, toxicity, and interaction with narcotic receptors in vitro.
The configuration of the halogen on  the C-ring of several alpha- and beta-halomorphides was determined by NMR. The analgesic potencies of these halomorphides and their interactions with narcotic receptors in a rat brain homogenate were measured, as was the toxicity of the alpha- and beta-chloromorphides. The halomorphides were examined as possible irreversible binders to the narcotic receptor.
D000700:Analgesics; D000818:Animals; D001921:Brain / Q000378:metabolism; D055598:Chemical Phenomena; D002621:Chemistry; D006219:Halogens; D066298:In Vitro Techniques; D009682:Magnetic Resonance Spectroscopy; D051379:Mice; D009020:Morphine / Q000494:pharmacology; D009022:Morphine Derivatives / Q000494:pharmacology* / Q000633:toxicity; D051381:Rats; D011930:Reaction Time / Q000187:drug effects; D011955:Receptors, Drug / Q000187:drug effects; D013329:Structure-Activity Relationship; D013997:Time Factors
D000700:Analgesics; D006219:Halogens; D009022:Morphine Derivatives; D011955:Receptors, Drug; C010887:chloromorphide; D009020:Morphine