title: [The estradiol and estrone esters of [103Ru]ruthenocenecarboxylic acid. Synthesis, excretion and organ distribution (author's transl)].
abstract: The synthesis of the estradiol-17beta and estrone esters of ferrocenecarboxylic acid is described. The exchange reaction of these compounds with [103Ru]RuCl3 produced the corresponging [103Ru]ruthenocene compounds. The excretion and organ distribution of these estrogen esters in mice were quite different from those of [103Ru]ruthenocenecarboxylic acid and its methyl ester. The 103Ru-labelled estrogen esters are compared to 125I or 135I-labelled derivatives with respect to possible applications.
mesh_terms: D000818:Animals; D004958:Estradiol / Q000031:analogs & derivatives* / Q000378:metabolism; D004970:Estrone / Q000031:analogs & derivatives* / Q000378:metabolism; D005260:Female; D007700:Kinetics; D008722:Methods; D051379:Mice; D012428:Ruthenium; D014018:Tissue Distribution
chemical_list: D004970:Estrone; D004958:Estradiol; D012428:Ruthenium
vernacular_title: Ostradiol- und Ostron-Ester der [103Ru]Ruthenocencarbonsäure. Synthese, Exkretion und Organverteilung.