[Mechanism of the anti-inflammatory action of immunodepressants].
The effectiveness of immunodepressants in lingering exudative processes, their inhibitory action in the proliferative phase of inflammation, depression of the phagocytic activity of leucocytes, as well as suppressive influence on the development of a toxic pulmonary edema and upon generalized anaphylaction reaction was demonstrated in tests staged on rats and mice. The antiphlogistic action of immunodepressants was not abolished during the first hours after their administration by specific metabolites, but was suppressed at the peak of the cytostatic effect together with the latter. The phlogolytic effect was not mediated through the hypophysis-adrenal system and did not include the lienic factor.
D000707:Anaphylaxis / Q000188:drug therapy; D000818:Animals; D000893:Anti-Inflammatory Agents; D004305:Dose-Response Relationship, Drug; D004353:Drug Evaluation, Preclinical; D004359:Drug Therapy, Combination; D005472:Fluorouracil / Q000627:therapeutic use; D006099:Granuloma / Q000188:drug therapy; D007166:Immunosuppressive Agents / Q000627:therapeutic use*; D015122:Mercaptopurine / Q000627:therapeutic use; D008727:Methotrexate / Q000627:therapeutic use; D010587:Phagocytosis / Q000187:drug effects; D011654:Pulmonary Edema / Q000188:drug therapy; D051381:Rats; D013997:Time Factors
D000893:Anti-Inflammatory Agents; D007166:Immunosuppressive Agents; D015122:Mercaptopurine; D005472:Fluorouracil; D008727:Methotrexate
K mekhanizmu protivovspalitel'nogo deĭstviia nekotorykh immunodepressantov.