Effect of malononitrile dimer on RNA concentration of neurons as demonstrated by azure B staining.
Malononitrile dimer was administered to mice by single or by chronic (40 day) injections. The concentration of RNA in neurons of the brain was determined on histological sections by means of azure B staining. The nucleolus and Nissl substance of the several types of large neurons studied had a significantly higher concentration of RNA in the drug-injected than in the control animals.
D000818:Animals; D001399:Azure Stains; D001921:Brain / Q000378:metabolism / Q000648:ultrastructure; D001923:Brain Chemistry; D002466:Cell Nucleolus / Q000378:metabolism / Q000648:ultrastructure; D005260:Female; D051379:Mice; D009474:Neurons / Q000378:metabolism* / Q000648:ultrastructure; D009562:Nissl Bodies / Q000378:metabolism / Q000648:ultrastructure; D009570:Nitriles / Q000494:pharmacology*; D010640:Phenothiazines; D012313:RNA / Q000032:analysis / Q000378:metabolism*; D013116:Spinal Cord / Q000378:metabolism / Q000648:ultrastructure
D001399:Azure Stains; D009570:Nitriles; D010640:Phenothiazines; D012313:RNA