Bone histology in incipient and advanced renal failure.
Quantitative bone histology (micromorphometry of undecalcified sections, analysis under polarized light; fluorescence microscopy with tetracycline double labelling) as well as serum and urinary chemistry (creatinine clearance, parathyroid hormone, ionized Ca, bone phosphatase, pH), were studied in 50 patients with incipient to advanced (glomerular filtration rate, 80 to 6 ml/min x 1.73 m2 renal insufficiency. In incipient renal failure, indirect evidence of parathyroid hormone excess was found in the skeleton (empty osteoclastic lacunae, woven osteoid). Osteoclastic surface resorption was  abnormally high when GFR fell below 50ml/min x 1.73 m2. With the tetracycline double-labelling technique, a mineralization defect was demonstrable in many but not all patients.
D000138:Acidosis / Q000097:blood; D000328:Adult; D000469:Alkaline Phosphatase / Q000097:blood; D001857:Bone Matrix / Q000473:pathology; D001862:Bone Resorption / Q000473:pathology; D002118:Calcium / Q000097:blood; D012080:Chronic Kidney Disease-Mineral and Bone Disorder / Q000473:pathology*; D003720:Densitometry; D005260:Female; D005919:Glomerular Filtration Rate; D006801:Humans; D007085:Ilium / Q000032:analysis / Q000473:pathology*; D007676:Kidney Failure, Chronic / Q000097:blood / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D008903:Minerals / Q000032:analysis; D010010:Osteoclasts / Q000473:pathology; D010026:Osteosclerosis / Q000473:pathology; D010281:Parathyroid Hormone / Q000097:blood
D008903:Minerals; D010281:Parathyroid Hormone; D000469:Alkaline Phosphatase; D002118:Calcium