Biotransformation, a new approach to aminoglycoside biosynthesis: II. Gentamicin.
Utilizing a paromamine-producing mutant of Micromonospora purpurea blocked in the production of gentamicin, bioconversion of various minor gentamicin components into the gentamicin C complex was demonstrated. The compounds tested were structurally related to the gentamicin C's and are found as minor components in the gentamicin fermentation. Based upon the bioconversions detected, a branched pathway for the biosynthesis of the gentamicin C components is proposed.
D001711:Biotransformation; D003470:Culture Media; D005839:Gentamicins / Q000031:analogs & derivatives* / Q000032:analysis / Q000096:biosynthesis; D008847:Micromonospora / Q000378:metabolism*; D009154:Mutation; D010070:Oxalates / Q000378:metabolism
D003470:Culture Media; D005839:Gentamicins; D010070:Oxalates