Methamphetamine self-administration in the cat.
A procedure for studing intravenous drug self-administration in the cat is described. Ten cats were given 24-h access to methamphetamine reinforcement (0.04 mg/kg/inj). The subjects maintained a significantly higher response rate for drug reinforcement than for saline. The pattern of self-administration over days alternated between periods of high and low drug intake. Six additional cats were used to study the effect of dose per injection on methamphetamine self-administration under conditions of limited access. When methamphetamine was subtituted at various doses per infusion in animals maintained on cocaine reinforcement, response rate was shown to be an inverted U-shaped function of dose. These studies demonstrate that methamphetamine is a reinforcer in the cat and its patterns of intake under conditions of 24-h and limited access resemble other species.
D000818:Animals; D002415:Cats; D003042:Cocaine / Q000008:administration & dosage; D005260:Female; D007263:Infusions, Parenteral; D008694:Methamphetamine / Q000008:administration & dosage* / Q000494:pharmacology; D011600:Psychopharmacology / Q000379:methods; D012054:Reinforcement, Psychology; D012653:Self Stimulation
D008694:Methamphetamine; D003042:Cocaine