title: Kinetic evaluation of thiopentone sodium stability in aqueous and propylene glycol medium.
abstract: Stability of thiopentone sodium (TP) was investigated by means of accelerated testing at elevated temperature and pH ca. 10. The experiments carried out do not argue for propylene glycol as a good solvent for the preparations of an injectable TP solution because the shelf-life time predicted is more favourable for the aqueous solution.
mesh_terms: D004355:Drug Stability; D007700:Kinetics; D011409:Propylene Glycols; D013056:Spectrophotometry, Ultraviolet; D013696:Temperature; D013816:Thermodynamics; D013874:Thiopental / Q000032:analysis*; D014867:Water
chemical_list: D011409:Propylene Glycols; D014867:Water; D013874:Thiopental