[Comparative pharmacological effects of dl-amphetaminil and dl-amphetamine in the rat].
The present investigation shows that amphetamine and amphetaminil produce identical pharmacological effects (increase in motility and body temperature, anorexia, stereotypic behaviour). There was neither a qualitative difference under "open field" conditions nor a difference in the capacity of modifying the reserpine induced syndrome. In isomolar doses amphetamine was somewhat more effective. Almost the same amounts of amphetamine were found in blood and brain following amphetamine or amphetaminil administration, with exception of somewhat higher peak levels after amphetamine. These results favor the hypothesis that amphetaminil effects are produced by the amphetamine molecule.
D000097:Acetonitriles / Q000494:pharmacology*; D000607:Aminoacetonitrile / Q000031:analogs & derivatives / Q000378:metabolism / Q000494:pharmacology*; D000661:Amphetamine / Q000494:pharmacology*; D000818:Animals; D001066:Appetite / Q000187:drug effects; D001522:Behavior, Animal / Q000187:drug effects*; D001831:Body Temperature / Q000187:drug effects; D001921:Brain / Q000378:metabolism; D004305:Dose-Response Relationship, Drug; D006801:Humans; D008297:Male; D009043:Motor Activity / Q000187:drug effects; D051381:Rats; D012110:Reserpine / Q000037:antagonists & inhibitors; D013239:Stereotyped Behavior
D000097:Acetonitriles; D000607:Aminoacetonitrile; D012110:Reserpine; D000661:Amphetamine
Vergleich pharmakologischer Effekte von dl-Amphetaminil und dl-Amphetamin bei der Ratte