The effect of intra-uterine contraceptive devices on the oestrogen-induced incorporation of [3H-5]uridine into RNA by the rat uterus.
A length of copper or stainless steel wire or of silk thread suture was inserted as an intra-uterine device (IUD) for 3 days in the right uterine horn of ovariectomized virgin female rats. The left horn served as a control. The control rats were ovariectomized but had no IUD inserted. The in vitro incorporation of [3H-5]uridine into uterine RNA was significantly inhibited (P less than 0.005) in copper-bearing horns compared to control horns, while silk and steel devices had no inhibitory effect, thus indicating an effect of intra-uterine copper on oestradiol-induced uterine metabolism. The insertion of an intra-uterine device had no significant effect on uterine wet weight, DNA content or on the uptake of [3H-5]uridine into the nucleotide pool.
D000818:Animals; D003300:Copper; D004247:DNA / Q000378:metabolism; D004958:Estradiol / Q000494:pharmacology; D005260:Female; D007434:Intrauterine Devices; D009929:Organ Size; D012313:RNA / Q000378:metabolism*; D051381:Rats; D013232:Steel; D013784:Textiles; D014529:Uridine / Q000378:metabolism*; D014599:Uterus / Q000378:metabolism*
D013232:Steel; D004958:Estradiol; D012313:RNA; D003300:Copper; D004247:DNA; D014529:Uridine