[Study of the virustatic action of rimantadine based on a phage-bacterium model].
The action of rimantadin on the lambda phages was studied. The maximal inhibitory effect on the compound was observed on the 1st-6th minutes after the infection. There was no such effect on the T-4 and lambda phage replication. According to the data of incorporation of the radioactive precursors into the phage DNA,  RNA,  and proteins, and the manifestation of the rimantadin action on phage replication it was supposed that the inhibitory effect of rimantadin was determined by its influence on the RNA-polymerases, preponderantly on the phage RNA-polymerase.
D000218:Adamantane / Q000031:analogs & derivatives / Q000494:pharmacology*; D000998:Antiviral Agents / Q000494:pharmacology*; D001426:Bacterial Proteins / Q000096:biosynthesis; D001952:Bridged-Ring Compounds / Q000494:pharmacology*; D003090:Coliphages / Q000187:drug effects*; D004269:DNA, Bacterial / Q000096:biosynthesis; D004279:DNA, Viral / Q000096:biosynthesis; D012329:RNA, Bacterial / Q000096:biosynthesis; D012367:RNA, Viral / Q000096:biosynthesis; D014764:Viral Proteins / Q000096:biosynthesis; D014779:Virus Replication / Q000187:drug effects*
D000998:Antiviral Agents; D001426:Bacterial Proteins; D001952:Bridged-Ring Compounds; D004269:DNA, Bacterial; D004279:DNA, Viral; D012329:RNA, Bacterial; D012367:RNA, Viral; D014764:Viral Proteins; D000218:Adamantane
Izuchenie virostaticheskogo deĭstviia rimantadina na modeli fag-bakteriia