Efficiency of praziquantel, a new cesticide, against Taenia hydatigena in the dog.
Praziquantel (2 - cyclohexylcarbonyl - 1,3,4,6,7,11b - hexahydro - 2H - pyrazino (2,1 - a) isoquinolin - 4 - one) was tested against artificially established infections of Taenia hydatigena in 39 dogs. The formulation used was a 660 mg tablet containing 50 mg of active ingredient (ai). A single oral dose at 1 mg/kg ai completely removed 14-day-old infections in all dogs. 2.5 mg/kg ai praziquantel was completely effective against 7, 14 and 28-day-old worms. 5 mg/kg ai completely removed two-day-old infestations. No side effects were seen in any treated dog.
D000818:Animals; D000923:Anticestodal Agents / Q000627:therapeutic use*; D004283:Dog Diseases / Q000188:drug therapy*; D004285:Dogs; D007546:Isoquinolines / Q000627:therapeutic use*; D011719:Pyrazines / Q000627:therapeutic use; D013622:Taeniasis / Q000188:drug therapy / Q000662:veterinary*
D000923:Anticestodal Agents; D007546:Isoquinolines; D011719:Pyrazines