The renin-angiotensin system, dietary salt, and increased sensitivity to noradrenaline in mesenteric vasculature preparations from renal/salt hypertensive rats.
Exogenous angiotensin II causes noradrenaline supersensitivity in rat mesenteric vasculature preparations. The noradrenaline supersensitivity of tissues from renal/salt hypertensive rats, with low plasma renin activity, is not caused by endogenous angiotensin II since it was unaffected by Sar1 Ileu8 angiotensin II. Dietary salt-loading caused a small increase in noradrenaline sensitivity.
D000804:Angiotensin II / Q000037:antagonists & inhibitors / Q000097:blood / Q000494:pharmacology*; D000818:Animals; D001808:Blood Vessels / Q000187:drug effects; D004032:Diet; D004357:Drug Synergism; D005260:Female; D006977:Hypertension, Renal / Q000097:blood / Q000503:physiopathology*; D066298:In Vitro Techniques; D008643:Mesentery / Q000098:blood supply*; D009638:Norepinephrine / Q000494:pharmacology*; D051381:Rats; D012083:Renin / Q000097:blood*; D012965:Sodium Chloride / Q000494:pharmacology*
D000804:Angiotensin II; D012965:Sodium Chloride; D012083:Renin; D009638:Norepinephrine