[The effect of silymarin-N-methylglucamine salt and silybin-dihemisuccinate on (1-14C)-acetate incorporation in rat liver lipids (author's transl)].
60 min after i.v. application of 140.5 mg silymarin-N-methylglucamine salt/kg body weight dissolved in 4% polyvinylpyrrolidone solution, and 30 min after i.p. administration [1-14C]-acetate, compared to rats treated with solvent only, a statistically significant increase of specific radioactivities in total lipids, triglycerides, total phospholipids as well as in the phosphatidylcholine fraction and a decrease of specific activities in the free cholesterol fraction of the liver can be determined. 70 min after i.p. application of 140.5 mg silybin-dihemisuccinate/kg body weight dissolved in phosphate buffer, and 10 min after i.v. administration of [1-14C]-acetate in comparison with rats treated with solvent only, a statistically significant enhancement of specific activities of total liver lipids, free hepatic cholesterol, liver triglycerides, total liver phospholipids, and the hepatic fraction of phosphatidyl ethanolamine can be measured. Silybin also produces an increased specific radioactivity of the serum triglyceride fraction.
D000085:Acetates / Q000378:metabolism*; D000818:Animals; D002784:Cholesterol / Q000378:metabolism; D005419:Flavonoids / Q000494:pharmacology*; D007274:Injections, Intraperitoneal; D007275:Injections, Intravenous; D008055:Lipids / Q000032:analysis / Q000096:biosynthesis*; D008099:Liver / Q000187:drug effects / Q000378:metabolism*; D010713:Phosphatidylcholines / Q000378:metabolism; D010714:Phosphatidylethanolamines / Q000378:metabolism; D010743:Phospholipids / Q000378:metabolism; D051381:Rats; D012838:Silymarin / Q000008:administration & dosage / Q000031:analogs & derivatives / Q000494:pharmacology*; D014280:Triglycerides / Q000378:metabolism
D000085:Acetates; D005419:Flavonoids; D008055:Lipids; D010713:Phosphatidylcholines; D010714:Phosphatidylethanolamines; D010743:Phospholipids; D012838:Silymarin; D014280:Triglycerides; D002784:Cholesterol
Die Wirkung von Silymarin-N-methylglucamin-Salz und Silybin-dihemisuccinat auf den Einbau von (1-14C)-Acetat in die Lipide der Rattenleber