title: Inhibition of spontaneous contractility of the human and the rabbit fallopian tube by potassium.
abstract: Spontaneous contractions of circular and longitudal muscle of the ampulla and isthmus of human and rabbit Fallopian tubes were recorded isometrically. Addition of K+ to tissue in K+-free medium always caused immediate inhibition of spontaneous contractility. K+-induced inhibition was prevented by ouabain and reversed by removal of K+. It is suggested that K+ caused inhibition of contractility by activating electrogenic Na+ pumping with resultant hyperpolarization of the muscle cells.
mesh_terms: D000818:Animals; D005187:Fallopian Tubes / Q000187:drug effects* / Q000502:physiology; D005260:Female; D006801:Humans; D009130:Muscle, Smooth / Q000187:drug effects; D010042:Ouabain / Q000494:pharmacology; D010066:Ovum Transport; D011188:Potassium / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D011817:Rabbits; D012964:Sodium / Q000378:metabolism
chemical_list: D010042:Ouabain; D012964:Sodium; D011188:Potassium