Nature of lethality of t mutations in embryos.
Mutations in the genes of the T complex in mice can lead to death at various stages of embryogenesis. It has been suggested that the T genes specify cell surface antigens which are essential for normal organisation of certain cells within the embryo. But, there is now evidence that at least some of these T complex mutations are simply generalised cell lethals.
D000818:Animals; D001755:Blastocyst / Q000166:cytology; D002454:Cell Differentiation; D004477:Ectogenesis; D004707:Endoderm / Q000166:cytology; D005804:Genes, Lethal; D005865:Gestational Age; D051379:Mice / Q000196:embryology / Q000235:genetics*; D009154:Mutation; D014327:Trophoblasts / Q000166:cytology