Drug induction and experimental cholestasis.
The occlusion of bile duct reduced the microsomal cytochrome P-450 activity in the liver of rats. However, the effects of the inducer drug, phenobarbital, were not abolished.
D000410:Alanine Transaminase / Q000097:blood; D000818:Animals; D001219:Aspartate Aminotransferases / Q000097:blood; D001663:Bilirubin / Q000097:blood; D002779:Cholestasis / Q000097:blood / Q000378:metabolism*; D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism; D004347:Drug Interactions; D004790:Enzyme Induction; D005260:Female; D007770:L-Lactate Dehydrogenase / Q000097:blood; D008297:Male; D008862:Microsomes, Liver / Q000378:metabolism; D010424:Pentobarbital / Q000494:pharmacology; D010634:Phenobarbital / Q000494:pharmacology; D051381:Rats
D003577:Cytochrome P-450 Enzyme System; D007770:L-Lactate Dehydrogenase; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase; D010424:Pentobarbital; D001663:Bilirubin; D010634:Phenobarbital