Change in antikaliuretic response to potassium-sparing diuretics in patients with cirrhotic ascites.
In 2 elderly patients with ascites due to hepatic cirrhosis, potassium excretion decreased during re-administration of potassium-sparing diuretics after recurrence of ascites following withdrawal of previous prolonged treatment. An exaggerated antikaliuretic response and a paradoxic rise in potassium excretion are "unpredictable" changes which may occur during administration of potassium-sparing diuretics at different times in the same patient treated with the same drug.
D000368:Aged; D001201:Ascites / Q000188:drug therapy* / Q000209:etiology / Q000652:urine; D004232:Diuretics / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D008103:Liver Cirrhosis / Q000150:complications* / Q000652:urine; D008297:Male; D008875:Middle Aged; D011188:Potassium / Q000008:administration & dosage / Q000378:metabolism* / Q000652:urine
D004232:Diuretics; D011188:Potassium