[Effect of a new hypoglycemic drug on the blood sugar in rats].
A sesquiterpenic lactone has been isolated from an extract of Artemisia cannariensis Lee by Clark's method and column chromatography. The hypoglycemic effects of the drug have been assayed in rats, as compared to different doses of insulin and a known sulphonylures drug. The subatance, which has been identified as vulgarine by professor Gonzalez, has highly significant hypoglycemic effects when administered orally or intravenously in relation to glycemia curves of rats previously injected with saline.
D000284:Administration, Oral; D000818:Animals; D001786:Blood Glucose / Q000378:metabolism*; D007004:Hypoglycemic Agents / Q000008:administration & dosage / Q000494:pharmacology*; D007275:Injections, Intravenous; D007328:Insulin / Q000008:administration & dosage / Q000378:metabolism*; D007783:Lactones / Q000008:administration & dosage / Q000494:pharmacology*; D010936:Plant Extracts; D051381:Rats
D001786:Blood Glucose; D007004:Hypoglycemic Agents; D007328:Insulin; D007783:Lactones; D010936:Plant Extracts
Acción de un nuevo hipoglucemiante natural sobre glucemia en ratas