Action of testosterone in melanin metabolism in liver of toad (Bufo melanostictus).
The melanin content of liver of male toad was altered by testosterone injection. A single injection of testosterone at a dose of 1 microgram/g or 2 microgram/g of body weight caused an increase in melanin content of liver of male toad on the 3rd and 5th day after injection. With lower doses (0.1 microgram/g and 0.5 microgram/g), however, there was no alteration of melanin content of liver. Compared to the results obtained with 1 microgram of testosterone per g of body weight, the degree of response with respect to the melanin content with 2 microgram/g tended to be higher, but the difference was not statistically significant. The female toads remained unaffected with respect to melanin content of liver with these doses of testosterone used.
D000818:Animals; D002025:Bufonidae; D005260:Female; D007700:Kinetics; D008099:Liver / Q000187:drug effects / Q000378:metabolism*; D008297:Male; D008543:Melanins / Q000378:metabolism*; D012737:Sex Factors; D013739:Testosterone / Q000494:pharmacology*
D008543:Melanins; D013739:Testosterone