title: A synthesis of 7alpha-hydroxyandrost-4-ene-3,17-dione.
abstract: The first convenient chemical synthesis of 7alpha-hydroxyandrost-4-ene-3,17-dione is reported. Androsta-4,6-diene3, 17-dione was converted into its 6alpha, 7alpha-epoxy-derivative; reduction of the epoxide with aluminum amalgam gave 7alpha-hydroxyandrost-4-ene-3,17-dione. This reducing agent is more efficient than chromous acetate for the purpose.
mesh_terms: D000735:Androstenedione / Q000031:analogs & derivatives* / Q000138:chemical synthesis; D006914:Hydroxysteroids / Q000138:chemical synthesis; D008722:Methods; D010084:Oxidation-Reduction
chemical_list: D006914:Hydroxysteroids; D000735:Androstenedione