Respiration-dependent efflux of magnesium ions from heart mitochondria.
Energy-linked respiration causes a net movement of Mg2+ between rat heart mitochondria and the ambient medium. When the extramitochondrial concontration of Mg2+ is less that about 2.5 mM the net movement of Mg2+ constitutes an efflux, whereas a net influx of Mg2+ occurs when the external concentration of Mg2+ is greater than this. Both the efflux and the influx are induced to only a very small degree by externally added ATP. Evidence suggests that Pi may be required for the respiration-induced efflux of Mg2+.
D000244:Adenosine Diphosphate / Q000494:pharmacology; D000255:Adenosine Triphosphate / Q000494:pharmacology; D000818:Animals; D002118:Calcium / Q000494:pharmacology; D004579:Electron Transport; D066298:In Vitro Techniques; D007656:Ketoglutaric Acids / Q000494:pharmacology; D008274:Magnesium / Q000378:metabolism*; D008931:Mitochondria, Muscle / Q000378:metabolism*; D009206:Myocardium / Q000378:metabolism*; D009840:Oligomycins / Q000494:pharmacology; D010101:Oxygen Consumption; D010710:Phosphates / Q000032:analysis / Q000494:pharmacology; D051381:Rats; D012402:Rotenone / Q000494:pharmacology
D007656:Ketoglutaric Acids; D009840:Oligomycins; D010710:Phosphates; D012402:Rotenone; D000244:Adenosine Diphosphate; D000255:Adenosine Triphosphate; D008274:Magnesium; D002118:Calcium