Cloxacillin penetration.
We investigated the intraocular penetration of cloxacillin in 14 patients undergoing surgery for senile cataract after intramuscular and subconjunctival injections of the drug. No antibiotic level was detected in the aqueous humor when cloxacillin was administered intramuscularly in a dose that ranged between 1 and 4 g. With subconjunctival injection, therapeutically effective cloxacillin activity was detected in the aqueous humor only after a dose of 250 mg.
D001082:Aqueous Humor / Q000378:metabolism*; D002387:Cataract Extraction; D003023:Cloxacillin / Q000008:administration & dosage / Q000378:metabolism* / Q000627:therapeutic use; D005128:Eye Diseases / Q000188:drug therapy; D005260:Female; D006801:Humans; D007239:Infections / Q000188:drug therapy; D007273:Injections, Intramuscular; D008297:Male
D003023:Cloxacillin