title: The effect of isosorbide dinitrate following experimental coronary occlusion.
abstract: The results of the present investigation indicate that ISDN infusion following experimental coronary occlusion in anesthetized dogs (1) lowers systemic, cardiac, and pulmonary blood pressures; (2) decreases systemic resistance; (3) has no significant effect on cardiac output, heart rate, and stroke volume; (4) decreases serum CPK levels; and (5) has little effect on blood biochemical parameters. These results suggest that ISDN may have a minimal effect on the ischemic heart by means of a slight decrease in peripheral vascular resistance and systemic blood pressure.
mesh_terms: D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D002302:Cardiac Output / Q000187:drug effects; D003327:Coronary Disease / Q000097:blood / Q000188:drug therapy* / Q000209:etiology / Q000401:mortality; D003402:Creatine Kinase / Q000097:blood; D004195:Disease Models, Animal; D004285:Dogs; D004353:Drug Evaluation, Preclinical; D007548:Isosorbide Dinitrate / Q000627:therapeutic use*; D008297:Male; D014655:Vascular Resistance / Q000187:drug effects
chemical_list: D003402:Creatine Kinase; D007548:Isosorbide Dinitrate