Regional ventricular dysfunction in coronary artery disease.
Percentage asynergy, ejection fraction (EF), left ventricular end diastolic pressure (LVEDP) and the site of coronary artery narrowing or obstruction were measured in 69 patients with significant coronary artery disease. Complete obstruction in the first third of the left anterior descending artery (LAD) produced a mean asynergy of 49% associated with an ejection fraction of 40% and a LVEDP of 19mm Hg. The extent of asynergy was modified by the nature of the underlying coronary artery anatomy and the protective circulation. Complete obstruction in the main right coronary artery produced a mean asynergy of 20% associated with an EF of 67% and LVEDP of 6 mm Hg. Complete obstruction in the first third of the circumflex artery produced a mean asynergy of 15% associated with an EF or 74% and LVEDP  of 14mm Hg. Subtotal obstruction in the first third of the LAD produced a mean asynergy of 25% associated with an EF of 62% and LVEDP  of 7mm Hg. The damage produced by a LAD obstruction was extensive while that of a right or circumflex obstruction was mild. Patients always had a high percentage asynergy after two episodes of myocardial infarction. A negative linear relationship was found between percentage asynergy and EF. There was a rough positive linear relationship between LVEDP and percentage asynergy.
D001794:Blood Pressure; D003327:Coronary Disease / Q000503:physiopathology*; D006321:Heart / Q000503:physiopathology*; D006801:Humans; D009200:Myocardial Contraction