title: Polychlorobornane components of toxaphene: structure-toxicity relations and metabolic reductive dechlorination.
abstract: 2,2,5-endo,6-exo,8,9,10-Heptachlorobornane and four derivatives of this heptachlorobornane, with an additional chlorine atom at position 3-exo,8,9, or 10, account for a major portion of the acute toxicity of toxaphene and for up to 23 percent of toxaphene composition as analyzed by open tubular column gas-liquid chromatography with an electron capture detector. Both in several organisms and model environmental systems and on photolysis, this heptachlorobornane undergoes facile reductive dechlorination at the geminal-dichloro group and sometimes dehydrochlorination.
mesh_terms: D000818:Animals; D055598:Chemical Phenomena; D002621:Chemistry; D007306:Insecticides / Q000031:analogs & derivatives; D051379:Mice; D051381:Rats; D013329:Structure-Activity Relationship; D014112:Toxaphene / Q000031:analogs & derivatives / Q000378:metabolism / Q000633:toxicity
chemical_list: D007306:Insecticides; D014112:Toxaphene