[Speed and intensity of the immune response to the administration of inactivated influenza vaccine in relation to neuraminidase activity].
A comparative study of the rate of appearance of specific virus antigen in immune competent organs of mice immunized with inactivated influenza vaccine with active neuraminidase or a vaccine devoid of the neuraminidase activity was carried out by means of the immunofluorescence test and the serological tests. A considerable delay in the time (by 16--18 hours) of detection of virus antigen in cells of lymph nodes of mice as well as later (1--2 days) and less intensive (2--4-fold) production of specific virus antibody was demonstrated after immunization of mice with the vaccine without the active enzyme.
D000818:Animals; D000917:Antibody Formation; D007252:Influenza Vaccines; D008297:Male; D051379:Mice; D009439:Neuraminidase; D013997:Time Factors; D014613:Vaccines, Attenuated
D007252:Influenza Vaccines; D014613:Vaccines, Attenuated; D009439:Neuraminidase
Bystrota i intensivnost' immunnogo otveta na vvedenie inaktivirovannoĭ protivogrippoznoĭ vaktsiny v zavisimosti ot aktivnosti neĭraminidazy