Evidence for a noncovalent intermolecular interaction of opiates with thiamine.
Opiate agonists and antagonists formed reversible molecular complexes with thiamine. The absorption maxima of these complexes were at wavelengths longer than those of the individual components and their intensities depended on the concentration and nature of the opiate component. The possible implications of such an interaction are discussed.
D055598:Chemical Phenomena; D002621:Chemistry; D009292:Narcotic Antagonists; D009294:Narcotics / Q000032:analysis; D013056:Spectrophotometry, Ultraviolet; D013831:Thiamine / Q000032:analysis; D013844:Thiazoles
D009292:Narcotic Antagonists; D009294:Narcotics; D013844:Thiazoles; D013831:Thiamine