title: [Combined chemotherapy of neuroblastoma. 1st results in 40 children with metastatic form].
abstract: 40 PATIENTS WITH METASTATIC NEUROBLASTOMA HAVE BEEN Treated by a sequential multichemotherapy made of vincristine, adriamycin and cyclophosphamide. Results of pre-treated complementary investigations are reported and discussed. Criterias are proposed to distinguish four evolutive types and their appreciation is done after three months. The chemotherapy used has no pronounced haematological toxicity, but one varicella and two interstitial pneumonias ended with death. Nearly 2/3 of these streated tumors are drug-responders : 15 complete apparent remissions which are lasting in 11 patients since four to eighteen months; and 13 good partial remissions. One third of the patients are drug-non responders. Actuarial survival of the whole group is 67% at 12 months.
mesh_terms: D000008:Abdominal Neoplasms / Q000188:drug therapy; D000293:Adolescent; D000328:Adult; D002648:Child; D002675:Child, Preschool; D003520:Cyclophosphamide / Q000627:therapeutic use; D004317:Doxorubicin / Q000627:therapeutic use; D004359:Drug Therapy, Combination; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007223:Infant; D008297:Male; D009362:Neoplasm Metastasis / Q000188:drug therapy*; D009447:Neuroblastoma / Q000188:drug therapy* / Q000401:mortality; D012075:Remission, Spontaneous; D013899:Thoracic Neoplasms / Q000188:drug therapy; D014750:Vincristine / Q000627:therapeutic use
chemical_list: D014750:Vincristine; D004317:Doxorubicin; D003520:Cyclophosphamide
vernacular_title: Chimiothérapie lourde dans le neuroblastome. Premiers resultats chez 40 enfants porteurs d'une forme metastatique