title: [Adrenaline application by intraperitoneal depot capsule -- effects in the heart (author's transl)].
abstract: An intraperitoneal depot capsule was developed to improve the hitherto used in vivo test methods for chronic action of water soluble substances (repeated injections or permanent infusion which immobilizes the experimental animals). The capsule allows free movement of the animal and guarantees long-term continuous output of the substance. The effectiveness of the capsule was examined using adrenaline as test substance. In these experiments the maximum period of effectiveness and the consequences of permanent occupation of the receptors due to continued supply of adrenaline were studied.
mesh_terms: D000818:Animals; D004343:Drug Implants; D004837:Epinephrine / Q000008:administration & dosage* / Q000378:metabolism / Q000494:pharmacology; D006321:Heart / Q000187:drug effects; D009206:Myocardium / Q000473:pathology; D009929:Organ Size; D010537:Peritoneum; D011674:Pulse; D051381:Rats; D013997:Time Factors
chemical_list: D004343:Drug Implants; D004837:Epinephrine
vernacular_title: Adrenalinapplikation durch eine intraperitoneale Depotkapsel -- Wirkungen auf das Herz.