Lithium-induced nephrogenic diabetes insipidus.
The etiology, diagnosis and management of lithium-induced diabetes insipidus (LIDI) is discussed, including the presentation of a case report. It is suggested that lithium provokes LIDI by decreasing the responsive ness of the kidney to the antidiuretic hormone. Lithium-induced polyuria may be managed by concomitant treatment with a thiazide diuretic or discontinuation of the lithium. Caution must be employed, however, when using thiazides with lithium as these diuretics decrease renal clearance of lithium.
D000328:Adult; D000818:Animals; D001001:Anura; D001581:Benzothiadiazines; D003919:Diabetes Insipidus / Q000139:chemically induced* / Q000188:drug therapy / Q000503:physiopathology; D004232:Diuretics; D006801:Humans; D066298:In Vitro Techniques; D008094:Lithium / Q000009:adverse effects*; D008297:Male; D049993:Sodium Chloride Symporter Inhibitors / Q000627:therapeutic use; D001743:Urinary Bladder / Q000502:physiology; D014667:Vasopressins / Q000627:therapeutic use
D001581:Benzothiadiazines; D004232:Diuretics; D049993:Sodium Chloride Symporter Inhibitors; D014667:Vasopressins; D008094:Lithium