Comparative effects of various naturally occurring cannabinoids on food, sucrose and water consumption by rats.
The effects of intraperitoneally injected detla9-tetrahydrocannabinol (THC), cannabinol (CBN) and cannabidiol (CBD) were compared to d-amphetamine sulfate (d-AMP) on food and water consumption and intake of two different concentrations of sucrose solutions. Three groups of rats were given the following dietary regimens within a 6-hr feed period day: 1 - water and dry food; 2 - water, dry food and five percent sucrose solution; 3 - water, dry food and 20% sucrose solution. Food and water consumption were dramatically reduced by each test drug at feeding periods immediately following and in some instances up to 4 days after dosing in all 3 groups. However, sucrose consumption was much less affected by each cannabinoid, inidcating a preference for sweet calories, whereas d-AMP had an equal anorexic action on both food and sucrose consumption. These data suggest for the first time in rats that a preference for sweet calories occurs during an overall anorexic effect of THC, CBN and CBD.
D000818:Animals; D002185:Cannabidiol / Q000494:pharmacology; D002188:Cannabis / Q000494:pharmacology*; D003864:Depression, Chemical; D003913:Dextroamphetamine / Q000494:pharmacology; D004327:Drinking Behavior / Q000187:drug effects*; D013759:Dronabinol / Q000494:pharmacology; D005247:Feeding Behavior / Q000187:drug effects*; D008297:Male; D051381:Rats; D013395:Sucrose; D013997:Time Factors
D002185:Cannabidiol; D013395:Sucrose; D013759:Dronabinol; D003913:Dextroamphetamine