[Electron microscopic study of intestinal auto-, allo- and xenotransplants in the 1st hours following extracorporeal perfusion].
Mucous membrane ultrastructure was studied after extracorporeal perfusion of the small intestine under auto- (12 experiments), allo- (10 experiments) and xenotransplantations (4 experiments). In all mucosal structures the lesions are demonstrated to depend on nonspecific factors on the one hand, and on genetically foreigh tissue, on the other hand. In every experimental group, the earliest changes occur in microcirculatory bed. Disorders in vessel and blood flow tone lymphotasis and interstitial edema result in disturbances of capillary-epithelial interrelations and metabolic processes. Destructive changes are followed by tissue neutrophilosis, activation of macrophages and plasmocytic cells, degranulation of eosinophil, enterochromaffin and mast cells, profound mucin excretion. Unlike autoperfusion, alloperfusion is characterized by massive neutrophillic degranulation and more severe lesions of mucosal structures. At allotransplantation, neutrophil cell reaction (nonspecific by its nature) is supposed to be the earliest and primary in the course of establishing transplantation immunity. At xenotransplantation, intestinal destruction, developing and rapidly progressing, is connected with the influence of natural antibodies.
D000818:Animals; D002417:Cattle; D003594:Cytoplasmic Granules; D004285:Dogs; D004759:Enterochromaffin Cells / Q000648:ultrastructure; D007413:Intestinal Mucosa / Q000098:blood supply / Q000648:ultrastructure*; D007421:Intestine, Small / Q000637:transplantation*; D008208:Lymphatic System / Q000648:ultrastructure; D008407:Mast Cells / Q000648:ultrastructure; D008833:Microcirculation / Q000648:ultrastructure; D008854:Microscopy, Electron; D014181:Transplantation Immunology; D014182:Transplantation, Autologous; D014183:Transplantation, Heterologous; D014184:Transplantation, Homologous
Elektronnomikroskopicheskoe issledovanie kishechnogo auto-, allo- i ksenotransplantatov v pervye chasy posle ékstrakorporal'noĭ perfuzii.