title: 4-amino-6-(trichloroethenyl)-1,3-benzenedisulfonamide, a new, potent fasciolicide.
abstract: The synthesis and fasciolicidal activity of 4-amino-6-(trichloroethenyl)-1,3-benzenedisulfonamide are reported. A single dose of 15 mg/kg was effective in removing over 90% of immature Fasciola hepatica from sheep (6 weeks after infection) and calves (8 weeks after infection). A 2.5 mg/kg dose removed over 90% of mature (16 weeks old) liver fluke from sheep. Single oral doses up to 400 mg/kg were tolerated by sheep without gross toxic symptoms.
mesh_terms: D000818:Animals; D000871:Anthelmintics / Q000138:chemical synthesis / Q000627:therapeutic use* / Q000633:toxicity; D002417:Cattle; D005210:Fasciola hepatica; D005211:Fascioliasis / Q000188:drug therapy*; D012756:Sheep; D013424:Sulfanilamides; D013449:Sulfonamides / Q000138:chemical synthesis / Q000627:therapeutic use* / Q000633:toxicity; D014241:Trichloroethylene / Q000031:analogs & derivatives / Q000138:chemical synthesis / Q000627:therapeutic use
chemical_list: D000871:Anthelmintics; D013424:Sulfanilamides; D013449:Sulfonamides; D014241:Trichloroethylene; C015675:clorsulon