Magnesium concentrations in plasma and bone following enteral administration of Br-, Cl- and Mg++ in the form of different compounds and combinations.
In accordance with the results achieved in previous experiments the intestinal absorption of magnesium and its uptake into bone of rats were significantly improved when MgCl2 or mono-magnesium-mono-aspartate-hydrochloride (Mg asp. HCl) were used instead of mono-magnesium-di-l-aspartate (Mg asp.). Treatment with mono-magnesium-mono-aspartate-hydrobromide (Mg asp. HBr) resulted in remarkably elevated magnesium concentrations in plasma and bone. Since the animals were strongly sedated at the same time, we had to differentiate the influence of anesthesia from unspecific distress and specific actions of bromide and chloride, e.g. on intestinal uptake and/or renal excretion of Mg. Experiments in which the narcotic effect of bromide was reduced to moderate sedation by additional treatment with chloride would appear to suggest that both specific and unspecific mechanisms were involved. In additional experiments it was shown that the effects of Mg asp. plus KBr or Mg asp. plus KCl or CaCl2 were similar to those of the corresponding magnesium aspartate hydrohalogenides.
D000284:Administration, Oral; D000777:Anesthetics; D000818:Animals; D001224:Aspartic Acid / Q000008:administration & dosage; D001842:Bone and Bones / Q000032:analysis*; D001965:Bromides / Q000008:administration & dosage / Q000494:pharmacology*; D002415:Cats; D002712:Chlorides / Q000494:pharmacology*; D007408:Intestinal Absorption / Q000187:drug effects; D007441:Intubation, Gastrointestinal; D008274:Magnesium / Q000008:administration & dosage / Q000032:analysis* / Q000097:blood / Q000494:pharmacology; D008297:Male; D051381:Rats
D000777:Anesthetics; D001965:Bromides; D002712:Chlorides; D001224:Aspartic Acid; D008274:Magnesium