Psychiatric symptoms with initiation of carbidopa-levodopa treatment.
Two patients who had had no previous psychiatric symptoms became psychotic after their antiparkinsonism medication was changed from levodopa alone to a combination of levodopa and carbidopa, despite adherence to the appropriate and recommended dosage. Psychiatric symptoms disappeared after treatment with levodopa alone was resumed.
D000368:Aged; D002230:Carbidopa / Q000008:administration & dosage / Q000009:adverse effects* / Q000627:therapeutic use; D004359:Drug Therapy, Combination; D006801:Humans; D006834:Hydrazines / Q000009:adverse effects*; D007980:Levodopa / Q000008:administration & dosage / Q000009:adverse effects* / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged; D010300:Parkinson Disease / Q000188:drug therapy; D011605:Psychoses, Substance-Induced / Q000209:etiology*
D006834:Hydrazines; D007980:Levodopa; D002230:Carbidopa