title: [Humoral and cell-mediated immune reactions in chronic posttraumatic osteomyelitis (author's transl)].
abstract: The humoral and cell mediated immune response was investigated in 90 patients suffering from chronic posttraumatic osteomyelitis. In 10-20% of the patients the serum IgG and IgM was increased, in 5-10% the levels were decreased. The values were compared with those of a control group of 35 normal healthy volunteers. Of 55 patients with staphylococcal infection only 25 had a positive antistaphylolysin titer. Eleven out of 25 patients with staphylococcal osteomyelitis showed a positive in vitro lymphocyte transformation after stimulation with alpha-staphylolysin (mean transformation rate 5.4 equal to or less than 0.9). The phytohemagglutinin and the pokeweed-mitogen response were normal. A comparison of the immunological reactivity of the patients and the clinical severity of the disease showed that patients with established delayed-type hypersensitivity phenomena suffered a significantly worse clinical course of the disease.
mesh_terms: D000917:Antibody Formation; D000918:Antibody Specificity; D001424:Bacterial Infections / Q000150:complications; D002908:Chronic Disease; D005260:Female; D006801:Humans; D007111:Immunity, Cellular; D007136:Immunoglobulins / Q000302:isolation & purification; D008213:Lymphocyte Activation; D008297:Male; D010019:Osteomyelitis / Q000209:etiology / Q000276:immunology*; D013997:Time Factors; D014947:Wounds and Injuries / Q000150:complications*
chemical_list: D007136:Immunoglobulins
vernacular_title: Humorale und zelluläre Immunphänomene im klinischen Verlauf der chronischen posttraumatischen Osteomyelitis