A comparison of survival and repair of UV-induced DNA damage in cultured insect versus mammalian cells.
Survival and unscheduled DNA synthesis (UDS) were measured in a cultured insect cell line, TN-368, and a cultured mammalian cell line, V-79-4, following exposure to several fluences of ultraviolet light. TN-368 cells were approximately seven times more resistant to the lethal effects of UV than V-79 cells, as determined by colony formation. The amount of UDS per unit amount of DNA is about the same in both cell types 4 hr after 10-50 J/m2 UV irradiations.
D000818:Animals; D002470:Cell Survival; D002478:Cells, Cultured; D006224:Cricetinae; D004247:DNA / Q000096:biosynthesis / Q000528:radiation effects*; D004260:DNA Repair; D066298:In Vitro Techniques; D007313:Insecta / Q000235:genetics; D013997:Time Factors; D014466:Ultraviolet Rays
D004247:DNA