The metabolism of isopropylantipyrine in the rat and man.
1. The major urinary metabolite of isopropylantipyrine in the rat and man was an enol glucuronide of N-desmethyl isopropylanipyrine, which comprised about 80% of the whole urinary metabolites. 2. Six other minor metabolites occurred in rat urine; all lacked the N-methyl group of the parent drug, and some had undergone further oxidation at the isopropyl group, the phenyl group or in the C-4 position.
D000818:Animals; D000983:Antipyrine / Q000031:analogs & derivatives* / Q000378:metabolism / Q000652:urine; D002855:Chromatography, Thin Layer; D005965:Glucuronates / Q000652:urine; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D051381:Rats
D005965:Glucuronates; D000983:Antipyrine