Ferrihemoglobin formation by monohydroxy aniline derivatives in erythrocytes of some avian species in comparison with mammals.
Ferrihemoglobin formation nitrosobenzene and p-, m- and o-animophenol was studied in erythrocyte supspensions from a number of avian and mammalian species. Compared with the mammalian erythrocytes, bird red cells show little species differences in susceptibility. In birds, dose-effect relationship are different for nitrosobenzene and the aminophenols: using low concentration nitrosobenzene is more active than the aminophenols, while at higher concentrations o-aminophenol is at least equally effective. In birds, o-aminophenol is about eight times more potent than p-aminophenol. m-Anminophenol is not an inducer of ferrihemoglobin in erythrocytes of the cat, the goat and the Japanese quail.
D000814:Aniline Compounds / Q000494:pharmacology*; D000818:Animals; D001717:Birds / Q000097:blood*; D002415:Cats; D002645:Chickens; D010856:Columbidae; D003370:Coturnix; D004285:Dogs; D004912:Erythrocytes / Q000378:metabolism*; D006041:Goats; D006736:Horses; D008706:Methemoglobin / Q000096:biosynthesis*; D009603:Nitroso Compounds / Q000494:pharmacology; D013045:Species Specificity; D014422:Turkeys
D000814:Aniline Compounds; D009603:Nitroso Compounds; D008706:Methemoglobin; C012456:nitrosobenzene