The stability of synthetic substance P in blood.
Experiments with synthetic substance P incubated in whole blood show that apart from a moderate loss of activity immediately on exposure of the peptide to whole blood, it is inactivated slowly in this tissue, approximately 25% of control activity remaining after 30 min incubation. Incubation with plasma did not result in the degradation of substance P. The attenuation of substance P activity in blood may be due to enzymatic destruction within erythrocytes.
D000818:Animals; D004285:Dogs; D004355:Drug Stability; D004910:Erythrocyte Membrane; D006461:Hemolysis; D006801:Humans; D066298:In Vitro Techniques; D010949:Plasma; D011817:Rabbits; D013373:Substance P / Q000097:blood*; D013997:Time Factors
D013373:Substance P