Characterization of methylumbilliferone (mendiaxon r)-induced choleresis in the isolated perfused rat liver.
The influence of the choleretic drug methylumbilliferone on bile formation in the isolated perfused rat liver is characterized. The compound induces rapidly an elevation of bile flow, bile acid secretion and soium excretion. The increased production of bile is of canalicular origin. The choleretic effect was defined as "bile acid like" choleresis due to excretion of the drug into the bile. It is discussed that the excretion of methylumbilliferone can influence the transport of bile in form of a positive cooperation on transport mechanism.
D000818:Animals; D001646:Bile / Q000187:drug effects* / Q000378:metabolism; D001647:Bile Acids and Salts / Q000378:metabolism; D002756:Cholagogues and Choleretics; D006923:Hymecromone / Q000494:pharmacology*; D008099:Liver; D008297:Male; D010477:Perfusion; D051381:Rats; D012636:Secretory Rate / Q000187:drug effects; D014468:Umbelliferones / Q000494:pharmacology*
D001647:Bile Acids and Salts; D002756:Cholagogues and Choleretics; D014468:Umbelliferones; D006923:Hymecromone