Pharmacoangiography in experimental tumours. Evaluation of vasoactive drugs.
Pharmacoangiography with four vasoactive drugs was performed in experimental renal and hepatic tumours in rats in order to compare their ability to demonstrate tumour vascularity. Three vasoconstrictors, angiotensin, norepinephrine and vasopressin, and one vasodilator, tolazoline, were tested, vasoconstrictors giving most diagnostic information and the difference in effect among these sometimes being small and probably dose-related. This diagnostic effect is based upon the primitive character of tumour vessels, being unable to react upon a vasoactive stimulus. Angiotensin turned out to be the superior drug which corresponds to clinical experiences of this drug.
D000792:Angiography; D000804:Angiotensin II / Q000494:pharmacology*; D000818:Animals; D003110:Colonic Neoplasms / Q000098:blood supply / Q000000981:diagnostic imaging / Q000473:pathology; D007680:Kidney Neoplasms / Q000098:blood supply / Q000000981:diagnostic imaging* / Q000473:pathology; D008113:Liver Neoplasms / Q000098:blood supply / Q000000981:diagnostic imaging* / Q000473:pathology; D009368:Neoplasm Transplantation; D009374:Neoplasms, Experimental / Q000000981:diagnostic imaging; D009638:Norepinephrine / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D012513:Sarcoma, Experimental / Q000098:blood supply / Q000000981:diagnostic imaging / Q000473:pathology; D014043:Tolazoline / Q000494:pharmacology*; D014667:Vasopressins / Q000494:pharmacology*
D014667:Vasopressins; D000804:Angiotensin II; D014043:Tolazoline; D009638:Norepinephrine