Hepatic fibrinogen deposits in pre-eclampsia. Immunofluorescent evidence.
To investigate if fibrin (or fibrinogen), immunoglobulins and complement were present in the liver of patients with toxemia of pregnancy, we performed immunofluorescence studies on needle biopsies of pre-eclamptic women. Fibrin (or fibrinogen) outlining the hepatic sinusoids was found in all 12 cases; in two of them there were also large nodular deposits of fibrin (or fibrinogen) and to a lesser extent of IgG, IgM and C3 in areas of necrosis. Immunofluorescence study of 13 control liver biopsies, six from pregnant women, was negative. Our findings suggest that the factors involved in glomerular and hepatic injury are similar. To explain the predominant involvement of liver and kidney, we propose that in these organs, the vasospasm characteristic of toxemia is more severe; this enhanced severity, in the presence of a systemic yet mild blood hypercoagulability, would create adequate local conditions for the precipitation of fibrin-fibrinogen.
D000293:Adolescent; D000328:Adult; D003176:Complement C3 / Q000378:metabolism; D005260:Female; D005337:Fibrin / Q000378:metabolism*; D005340:Fibrinogen / Q000378:metabolism*; D006801:Humans; D007074:Immunoglobulin G / Q000378:metabolism; D007075:Immunoglobulin M / Q000378:metabolism; D007136:Immunoglobulins / Q000378:metabolism; D007770:L-Lactate Dehydrogenase / Q000097:blood; D008099:Liver / Q000378:metabolism* / Q000473:pathology; D011225:Pre-Eclampsia / Q000276:immunology / Q000378:metabolism* / Q000473:pathology; D011247:Pregnancy
D003176:Complement C3; D007074:Immunoglobulin G; D007075:Immunoglobulin M; D007136:Immunoglobulins; D005337:Fibrin; D005340:Fibrinogen; D007770:L-Lactate Dehydrogenase