title: Histopathologic considerations in the management of skin cancer.
abstract: A knowledge of the pathology and biologic behavior of skin cancers is essential for accurate diagnosis and effective treatment. The dual nature and newer concepts of squamous-cell carcinoma and basal-cell epithelioma are reviewed. Some difficulties encountered in differentiating the two are discussed, including the "basosquamous" problem, squamous metaplasia, and pseudoepitheliomatous hyperplasia. Sclerosis within basal-cell epitheliomas is discussed, specifically relating to its importance in treatment. Follicular involvement in epidermal malignant and pre-malignant lesions is presented as a possible cause of recurrence.
mesh_terms: D002280:Basal Cell Carcinoma / Q000209:etiology / Q000473:pathology*; D002281:Carcinoma, Basosquamous / Q000473:pathology; D002294:Carcinoma, Squamous Cell / Q000209:etiology / Q000473:pathology*; D006801:Humans; D007642:Keratosis / Q000473:pathology; D011230:Precancerous Conditions / Q000473:pathology; D012598:Sclerosis; D012878:Skin Neoplasms / Q000209:etiology / Q000473:pathology*; D013472:Sunlight