Synthesis and properties of 35S, 14C and 3H labeled S-alkyl glycerol ethers and derivatives.
Radioactive S-alkyl glycerol ethers have been synthesized with 35S, 14C and 3H labels as well as 3H/35S double labels. The synthesized compounds were converted to various derivatives which can serve to characterize the S-alkyl glycerol ethers. These included the isopropylidene derivative, oxidation with periodate to the aldehyde followed by reduction with LiAlH4 to the alcohol, and reaction of the alcohol with acetic anhydride to form the acetate derivative. Chemical analysis, IR, NMR, zonal TLC profile scans and GLC showed all the products to be greater than 99% pure. The GLC behavior of the aldehyde and acetate derivatives of both S-alkyl glycerol ethers and O-alkyl glycerol ethers on EGSS-X was compared.
D002250:Carbon Radioisotopes; D002849:Chromatography, Gas; D002855:Chromatography, Thin Layer; D004987:Ethers / Q000138:chemical synthesis; D005989:Glycerides / Q000138:chemical synthesis*; D007553:Isotope Labeling; D009682:Magnetic Resonance Spectroscopy; D008722:Methods; D013438:Sulfhydryl Compounds / Q000138:chemical synthesis; D013462:Sulfur Radioisotopes; D014316:Tritium
D002250:Carbon Radioisotopes; D004987:Ethers; D005989:Glycerides; D013438:Sulfhydryl Compounds; D013462:Sulfur Radioisotopes; D014316:Tritium