Central tyramine prevents hypertension in uninephrectomized DOCA-saline treated rats.
Prevention of high blood pressure in uninephrectomized, DOCA-saline treated rats was observed after treatment with central tyramine precursors. We suggest that the high blood pressure is either due to relative lack of tyrosine, which might be caused by the hyperactivity of tyrosine hydroxylase, or to hypoactivity of the decarboxylase: in both cases the result is diminished tyramine synthesis.
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects*; D001923:Brain Chemistry; D003900:Desoxycorticosterone / Q000494:pharmacology*; D006973:Hypertension / Q000517:prevention & control; D008297:Male; D008781:Methyltyrosines / Q000494:pharmacology; D009392:Nephrectomy; D051381:Rats; D014439:Tyramine / Q000494:pharmacology*; D014443:Tyrosine / Q000494:pharmacology
D008781:Methyltyrosines; D003900:Desoxycorticosterone; D014443:Tyrosine; D014439:Tyramine