Intermittent meningitic reaction with severe basophilia and eosinophilia in CNS leukaemia.
Light- and electron-microscope studies were performed on CSF cells from a patient with CNS leukaemia presenting with an intermittent meningitic reaction. Numerous fully matured basophilic and eosinophilic granulocytes with excess glycogen content accompained undifferentiated leukaemic blast cells in the CSF. Such a CSF cell reaction has not been previously reported. It is suggested that this isolated CSF reaction represents a special type of immediate hypersensitivity reaction triggered by an abnormal leukaemic giant cell clone, and mitigated by the accompanying eosinophilic granulocytes.
D000208:Acute Disease; D000293:Adolescent; D001491:Basophils; D002555:Cerebrospinal Fluid / Q000166:cytology; D004804:Eosinophils; D006801:Humans; D006969:Hypersensitivity, Immediate; D007938:Leukemia / Q000134:cerebrospinal fluid* / Q000150:complications / Q000276:immunology; D008297:Male; D008581:Meningitis / Q000134:cerebrospinal fluid* / Q000209:etiology / Q000276:immunology