Influence of pancuronium of potassium efflux produced by succinycholine.
Serum potassium (K+) levels were measured after thiopental, succinylcholine, pancuronium, and pretreatment with pancuronium prior to succinylcholine, in 100 patients divided into 4 groups of 25 patients each. Significant increases in serum K+ were found after succinylcholine (1 mg/kg). Administration of pancuronium in small doses (20 mug/kg) prior to succinylcholine (1 mg/kg) was effective not only in complete prevention of serum K+ elevation but also produced consistent decrease in serum K+ concentration below control values. Both thiopental and pancuronium produced moderate fall in serum K+ levels. Our observations indicate that pretreatment with pancuronium may play a beneficial role in patients at risk from succinylcholine hyperkalemia.
D000771:Anesthesia, Intravenous / Q000009:adverse effects*; D006801:Humans; D006947:Hyperkalemia / Q000139:chemically induced* / Q000517:prevention & control; D010197:Pancuronium / Q000494:pharmacology* / Q000627:therapeutic use; D011188:Potassium / Q000097:blood*; D013390:Succinylcholine / Q000009:adverse effects*; D013874:Thiopental / Q000494:pharmacology
D013390:Succinylcholine; D010197:Pancuronium; D013874:Thiopental; D011188:Potassium