title: Melanotic tumours (Blue Naevi) of spinal nerve roots.
abstract: Four cases interpreted as intraspinal blue naevi are reported. The patients were adults females with an age range between 22 and 60 yr. In three there was a single tumour arising from the cervical posterior nerve roots and in the fourth there were multiple tumours arising from the posterior nerve roots of the spinal cord and occurring within the cerebello--pontine angle. The histological appearances of the tumours were similar in every way to those of dermal blue naevi. One was of the more common spindle-celled type and three of the cellular variant. The tumours contained melanin-pigment, and spindle cells with dendritic bipolar processes of the type described in dermal blue naevi. One was of the more common spindle-celled type and three of the cellular variant. The tumours contained melanin pigment, and spindle cells with dendritic bipolar processes of the type described in dermal blue naevi. Definite evidence of malignant tranformation was found in two cases and in a third, the appearances were suggestive for early malignant change. Therefore, unlike their dermal equivalents, intraspinal blue naevi appear to have a greater propensity for malignant transformation. In each case a careful clinical examination failed to reveal any evidence of a primary malignant melanoma. In the one case who died and on whom necropsy was performed, the failure to identify a primary cutaneous, mucosal or ocular melanoma substantiated our contention that these tumours were primary.
mesh_terms: D000328:Adult; D002471:Cell Transformation, Neoplastic; D005260:Female; D006801:Humans; D008543:Melanins; D008875:Middle Aged; D009508:Nevus, Pigmented / Q000473:pathology*; D013120:Spinal Cord Neoplasms / Q000473:pathology*; D013126:Spinal Nerve Roots / Q000473:pathology*
chemical_list: D008543:Melanins