title: The effect of food on procainamide absorption.
abstract: The effect of food on the absorption characteristics of procainamide was assessed after oral administration of the drug to eight male patients in the fasting and postprandial states. Serum concentration-time curves showed no significant difference in peak serum levels of procainamide, in the time the peak value was reached, or in the area under the serum concentration-time curves, indicating the total amount of procainamide present in the serum. The bioavailability of procainamide appears not to be significantly altered by taking an oral dose with food.
mesh_terms: D000042:Absorption; D000284:Administration, Oral; D001702:Biopharmaceutics; D004339:Drug Compounding; D004347:Drug Interactions; D005215:Fasting; D005502:Food; D006801:Humans; D007408:Intestinal Absorption; D008297:Male; D011342:Procainamide / Q000008:administration & dosage / Q000097:blood / Q000378:metabolism*
chemical_list: D011342:Procainamide