Humoral antibody response in mice after single dose exposure to lead or cadmium.
A single dose of lead administered orally or intraperitoneally (IP) to mice stimulated formation of IgM antibody. Cadmium caused an increase in IgM antibody formation when injected ip but resulted in a slight decrease when given orally. Lead, orally or ip, significantly reduced IgG antibody but the IgG antibody response decreased only when cadmium was given orally and increased when injected ip. Since responses vary according to route of administration, experiments should be designed so that experimental exposure will simulate natural exposure in order to develop comparable data.
D000284:Administration, Oral; D000818:Animals; D000917:Antibody Formation / Q000187:drug effects*; D000921:Antibody-Producing Cells / Q000378:metabolism; D002104:Cadmium / Q000008:administration & dosage / Q000378:metabolism / Q000494:pharmacology*; D007074:Immunoglobulin G / Q000096:biosynthesis; D007075:Immunoglobulin M / Q000096:biosynthesis; D007156:Immunologic Memory / Q000187:drug effects; D007274:Injections, Intraperitoneal; D007668:Kidney / Q000378:metabolism; D007854:Lead / Q000008:administration & dosage / Q000378:metabolism / Q000494:pharmacology*; D051379:Mice
D007074:Immunoglobulin G; D007075:Immunoglobulin M; D002104:Cadmium; D007854:Lead