[Clinico-experimental evaluation of therapeutic effectiveness of 1-dihydroxyphenylalanine in circulatory insufficiency].
The indices of central hemodynamics and myocardial contractility were studied by poly- and mechanocardiography in 25 patients with stage I-IIA circulatory insufficiency prior to and after treatment with 1-dioxyphenlalanine. The content of lactic and pyruvic acids in the blood and erythrocyte permeability to 32P were determined at the same time. The activity of the redox enzymes was studied in rats with experimentally induced circulatory insufficiency on the background of 1-DOPA medication. It was established that contractility of the heart and indices of central hemodynamics improved due to the effect of 1-DOPA. A decrease in the lactate concentration and an elevation of the pyruvate level in the blood of patients were noted. In animal experiments increased activity of cytochrome oxidase, succinic dehydrogenase, and alkaline and acid phosphatase in the myocardium was demonstrated.
D000818:Animals; D001775:Blood Circulation; D003327:Coronary Disease / Q000188:drug therapy* / Q000503:physiopathology; D004295:Dihydroxyphenylalanine / Q000627:therapeutic use*; D004341:Drug Evaluation; D006439:Hemodynamics; D006801:Humans; D009200:Myocardial Contraction; D051381:Rats; D012214:Rheumatic Heart Disease / Q000188:drug therapy* / Q000503:physiopathology
D004295:Dihydroxyphenylalanine
Kliniko-eksperimental'naia otsenka terapevticheskoĭ effektivnosti 1-dioksifenilalanina pri nedostatochnosti krovoobrashcheniia.