Enhanced induction of immune resistance by concanavalin A-bound L1210 vaccine and an immunopotentiator prepared from Coriolus versicolor.
Combined administration of a vaccine consisting of a small number (2 X 10(6)) of L1210 murine leukemic cells treated with glutaraldehyde and concanavalin A and a protein-bound polysaccharide preparation of Coriolus versicolor induced synergistic resistance to L1210 leukemia in BALB/c X DBA/2CrF1 mice. This effect was dependent on the dose and timing of the administration of the protein-bound polysaccharide preparation, being most effective at the time of or 1 day after the second vaccination. Induced resistance was not cross-reactive with P388 murine leukemia, indicating specificity of resistance. This immunopotentiation by the protein-bound polysaccharide did not occur when L1210 cells treated with glutaraldehyde, but not with concanavalin A, were used as a vaccine.
D000818:Animals; D000951:Antigens, Neoplasm / Q000008:administration & dosage*; D001487:Basidiomycota / Q000276:immunology*; D003208:Concanavalin A / Q000494:pharmacology*; D007109:Immunity; D007167:Immunotherapy; D007939:Leukemia L1210 / Q000276:immunology* / Q000628:therapy; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D008811:Mice, Inbred DBA; D011134:Polysaccharides / Q000276:immunology; D013997:Time Factors
D000951:Antigens, Neoplasm; D011134:Polysaccharides; D003208:Concanavalin A