title: CGP 9000: a new orally active, broad-spectrum cephalosporin.
abstract: CGP 9000, (7-[D-2-amino-2-(1,4-cyclohexadienyl)-acetamido]-3-methoxy-3-cephem-4-carboxylic acid), is a new broad-spectrum cephalosporin antibiotic. Its antibacterial activity in vitro (MIC) is similar, but its bactericidal efficacy superior to that of cephalexin and cephradine. Upon oral administration to mice infected with various bacteria, CGP 9000 is, in general, 2 to 7 times more effective than either cephalexin or cephradine.
mesh_terms: D000818:Animals; D001419:Bacteria / Q000187:drug effects*; D001424:Bacterial Infections / Q000188:drug therapy; D002506:Cephalexin / Q000494:pharmacology / Q000627:therapeutic use / Q000633:toxicity; D002511:Cephalosporins / Q000494:pharmacology* / Q000627:therapeutic use / Q000633:toxicity; D002515:Cephradine / Q000494:pharmacology / Q000627:therapeutic use; D005260:Female; D007928:Lethal Dose 50; D051379:Mice; D013997:Time Factors
chemical_list: D002511:Cephalosporins; D002515:Cephradine; D002506:Cephalexin