title: Current clotting concepts in urology.
abstract: A modern outline of the physiology of coagulation, a simple approach to the use of laboratory investigation for patients with possible clotting disorders in unexplained hematuria and several illustrative cases are presented. The diagnosis and management of localized fibrinolysis in the genitourinary tract and intravascular coagulation as possible causes of post-prostatectomy hemorrhage are discussed. A minimum of a platelet count, fibrinogen assay and, if possible, measurement of fibrinogen-related antigens should be obtained before administration of epsilon aminocaproic acid.
mesh_terms: D000328:Adult; D000368:Aged; D000614:Aminocaproates / Q000627:therapeutic use; D001772:Blood Cell Count; D001777:Blood Coagulation; D001778:Blood Coagulation Disorders / Q000175:diagnosis*; D001779:Blood Coagulation Factors / Q000032:analysis; D001780:Blood Coagulation Tests; D001792:Blood Platelets; D005260:Female; D005340:Fibrinogen / Q000032:analysis; D005342:Fibrinolysis; D006417:Hematuria / Q000175:diagnosis* / Q000188:drug therapy; D006467:Hemophilia A / Q000175:diagnosis; D002836:Hemophilia B / Q000175:diagnosis; D006470:Hemorrhage / Q000175:diagnosis; D006487:Hemostasis; D006801:Humans; D008297:Male; D008875:Middle Aged; D011183:Postoperative Complications / Q000175:diagnosis; D011468:Prostatectomy
chemical_list: D000614:Aminocaproates; D001779:Blood Coagulation Factors; D005340:Fibrinogen