The effect on cortical mirror foci produced by ouabain of gamma-aminobutyric acid, dopamine and haloperidol injected into the rabbit caudate nucleus.
Epileptiform activity is inhibited by injection of dopamine, and potentiated by injections of haloperidol into the caudate nucleus. gamma-Aminobutyric acid (GABA) initially potentiates, and shortly after that inhibits the epileptoform activity in the cortex. The authors discuss a possibility of combined treatment of seizure states with dopamine-mimetic and GABA-mimetic agents.
D000613:Aminobutyrates / Q000494:pharmacology*; D000818:Animals; D002421:Caudate Nucleus; D004298:Dopamine / Q000008:administration & dosage / Q000494:pharmacology*; D004569:Electroencephalography; D006220:Haloperidol / Q000008:administration & dosage / Q000494:pharmacology*; D007267:Injections; D008297:Male; D010042:Ouabain / Q000494:pharmacology*; D011817:Rabbits; D013997:Time Factors; D005680:gamma-Aminobutyric Acid / Q000008:administration & dosage / Q000494:pharmacology*
D000613:Aminobutyrates; D005680:gamma-Aminobutyric Acid; D010042:Ouabain; D006220:Haloperidol; D004298:Dopamine