Treatment of vaccinial keratitis with vidarabine.
Vaccinial epithelial keratitis was produced in rabbits. When the therapeutic effect of vidarabine on the experimentally-induced disease was evaluated and compared to the effect of idoxuridine, vidarabine was found to be highly effective, substantially more effective than idoxuridine, and nontoxic to the eye.
D000818:Animals; D003320:Corneal Ulcer / Q000175:diagnosis; D004195:Disease Models, Animal; D005452:Fluoresceins; D007065:Idoxuridine / Q000627:therapeutic use; D007634:Keratitis / Q000188:drug therapy*; D011684:Purine Nucleosides / Q000627:therapeutic use*; D011817:Rabbits; D014616:Vaccinia virus / Q000187:drug effects* / Q000302:isolation & purification; D014740:Vidarabine / Q000009:adverse effects / Q000627:therapeutic use*; D014777:Virus Diseases / Q000188:drug therapy*
D005452:Fluoresceins; D011684:Purine Nucleosides; D014740:Vidarabine; D007065:Idoxuridine