Inhibition of human neutrophil chemotaxis and chemiluminescence by amphotericin B.
The effect of the antifungal drugs amphotericin B, fluocytosine, miconazole, griseofulvin, and nystatin on the chemotactic responsiveness of human neutrophils was studied. Amphotericin B in a concentration of 2 mug/ml inhibited chemotatic responsiveness, and in a concentration of 5 mug/ml it also inhibited chemiluminescence. The inhibition of chemotaxis could be reversed by washing the cells. The other antifungal drugs did not inhibit chemotaxis even in concentrations much higher than those obtained in human serum during treatment.
D000666:Amphotericin B / Q000494:pharmacology*; D002478:Cells, Cultured; D002633:Chemotaxis / Q000187:drug effects*; D005437:Flucytosine / Q000494:pharmacology; D006118:Griseofulvin / Q000494:pharmacology; D006801:Humans; D008163:Luminescent Measurements; D008825:Miconazole / Q000494:pharmacology; D009504:Neutrophils / Q000187:drug effects / Q000502:physiology*; D009761:Nystatin / Q000494:pharmacology; D010587:Phagocytosis; D015054:Zymosan
D009761:Nystatin; D006118:Griseofulvin; D008825:Miconazole; D000666:Amphotericin B; D015054:Zymosan; D005437:Flucytosine