Effects of pyridinolcarbamate on the cardiovascular system of the anesthetized dog after bilateral cervical vagotomy.
Pyridinolcarbamate (PDC) was injected at a dose of 10 mg/Kg of body weight into the femoral vein of anesthetized dogs with a bilateral cervical vagosympathotomy. At this dose, it produced a transitory decrease in systolic, diastolic, and mean arterial pressure and an increase in heart rate. In addition, it produced a more prolonged increase in stroke volume, peak aortic flow, cardiac output, and left ventricular minute work. It also lowered peripheral resistance and apparently decreased the vaso-constrictor action of injected norepinephrine (1 mug of active base/Kg of body weight). These data are consistent with the view that PDC has a direct action on the heart that is similar to that of norepinephrine and that PDC blocks the alpha adrenergic receptors of the systemic resistance vessels.
D000758:Anesthesia; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D002219:Carbamates / Q000494:pharmacology*; D002302:Cardiac Output / Q000187:drug effects; D002319:Cardiovascular System / Q000187:drug effects*; D004285:Dogs; D006321:Heart / Q000187:drug effects; D006339:Heart Rate / Q000187:drug effects; D006439:Hemodynamics / Q000187:drug effects*; D008297:Male; D009638:Norepinephrine / Q000494:pharmacology; D011727:Pyridinolcarbamate / Q000494:pharmacology*; D012039:Regional Blood Flow / Q000187:drug effects; D014628:Vagotomy; D014655:Vascular Resistance / Q000187:drug effects
D002219:Carbamates; D011727:Pyridinolcarbamate; D009638:Norepinephrine