Bioavailability of sulfadiazine in rabbits using tablets prepared by direct compression and fluidized-bed granulation.
Experimental sulfadiazine tablets prepared by direct compression, using a commercially available direct compression tablet mass, were compared with experimental sulfadiazine tablets prepared by fluidized-bed granulation and commercially available sulfadiazine tablets USP. The values for friability and the time required to release 10 and 50% of the direct compression tablets were between those of the fluidized-bed tablets and the commercial product. With the commercial tablet as a standard, the extent of bioavailability was determined in rabbits; it was slightly higher for both the direct compression and fluidized-bed tablets. A statistically significant difference was found between the direct compression tablets and the standard with respect to the extent of bioavailability and the time of the peak.
D000818:Animals; D001682:Biological Availability; D004339:Drug Compounding / Q000379:methods; D007700:Kinetics; D008297:Male; D011208:Powders; D011817:Rabbits; D013411:Sulfadiazine / Q000378:metabolism*; D013607:Tablets; D013997:Time Factors
D011208:Powders; D013607:Tablets; D013411:Sulfadiazine