Hypertension as complication of vesicoureteral reflux in children.
Eight cases are reported of female children presenting with hypertension and found to have primary vesicoureteral reflux with chronic pyelonephritis. In 6 patients renal function was essentially normal while 2 had azotemia and progessive renal deterioration. As a result of early surgical intervention in the form of antireflux procedures, occasionally combined with unilateral nephrectomy for renin-dependent lesions, 5 of the 8 had complete disappearance or amelioration of hypertension with stabilization of renal function. The interactions of each member of the triad--vesicoureteral reflux, pyelonephritis, and hypertension--are reviewed with emphasis on pertinent pathophysiologic concepts regarding their roles in the production of progressive renal deterioration.
D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D002908:Chronic Disease; D005260:Female; D006801:Humans; D006973:Hypertension / Q000209:etiology* / Q000628:therapy; D009392:Nephrectomy; D011704:Pyelonephritis / Q000150:complications / Q000601:surgery; D014567:Urography; D014718:Vesico-Ureteral Reflux / Q000150:complications* / Q000601:surgery