Effects of chronic beta-glycerophosphate administration on growth rate and serum, liver and bile lipid composition in the rat--a toxicity study.
The possible toxic effects of a high dose of orally administered disodium beta-glycerophosphate to the rat for a period of 33 weeks has been investigated. The studies revealed taht beta-glycerophosphate administration had no effect on either survival rat, body weight, hematological and liver function tests or on serum and liver lipids concentrations. All organ weights were similar in the control and experimental rats excepts for the kidneys which were significantly heavier in the beta-glycerophosphate-fed rats. The biliary phospholipids concentrations was significantly increased in the treated group as observed previously during short-term treatments. Histological examination of liver and kidneys did not reveal any pathological findings. These results suggest that long-term administration of beta-glycerophosphate did not induce any toxic manifestations. The observed hyperplasia of the kidneys was attributed to the effect of the sodium content of beta-glycerophosphate.
D000818:Animals; D001646:Bile / Q000187:drug effects / Q000378:metabolism*; D001835:Body Weight / Q000187:drug effects; D002784:Cholesterol / Q000378:metabolism; D005994:Glycerophosphates / Q000633:toxicity*; D006439:Hemodynamics; D050356:Lipid Metabolism; D008055:Lipids / Q000097:blood; D008099:Liver / Q000187:drug effects / Q000378:metabolism*; D008111:Liver Function Tests; D008297:Male; D009929:Organ Size / Q000187:drug effects; D010743:Phospholipids / Q000378:metabolism; D051381:Rats
D005994:Glycerophosphates; D008055:Lipids; D010743:Phospholipids; D002784:Cholesterol