Saving the aortic and pulmonary artery valves with total heart replacement.
The natural aortic and pulmonary artery valves can be saved with excision of the ventricles and inflow valves. These valves remain functional and unaltered with implantation of an artificial heart, when pumped for 96 and 122 days. The capacity of the artificial heart to meet the physiological needs of the animal, during exercise and body growth, over 3 and 4 mos has been documented. All of the parameters monitored in 2 experiments for 3 mos (and continuing) and 4 mos clearly demonstrates the efficacy of meeting the cardiac needs with an artificial heart.
D000818:Animals; D001021:Aortic Valve / Q000502:physiology; D001344:Autopsy; D001772:Blood Cell Count; D001774:Blood Chemical Analysis; D002417:Cattle; D006354:Heart, Artificial; D008297:Male; D010101:Oxygen Consumption; D005082:Physical Exertion; D010974:Platelet Aggregation; D011651:Pulmonary Artery / Q000502:physiology; D011664:Pulmonary Valve / Q000502:physiology; D012756:Sheep