Assessment of conventional criteria for the early diagnosis of thrombophlebitis with the 125I-fibrinogen uptake test.
Analysis of 55 positive tests of a total of 300 tests by conventional criteria revealed that 125I-fibrinogen provides useful information early enough for clinical management. Of the tests which were ultimately interpreted as positive by conventional criteria, at least one was positive at 3-4 hours in 67% of the tests and 98% of the tests were positive at 24 hours after the administration of 125I-fibrinogen. A 20% difference between contralateral identical locations of the legs and a 20% difference between adjacent locations of the ipsilateral leg were found with almost equal frequency in the positive tests, whereas a 20% increase at the same location was less sensitive. The 125I-fibrogen uptake test is a simple and accurate technique for early diagnosis of active thrombophlebitis.
D005340:Fibrinogen / Q000378:metabolism; D006801:Humans; D007457:Iodine Radioisotopes; D007866:Leg / Q000098:blood supply; D011877:Radionuclide Imaging; D013924:Thrombophlebitis / Q000000981:diagnostic imaging* / Q000378:metabolism
D007457:Iodine Radioisotopes; D005340:Fibrinogen