title: Electronmicroscopy of the replication of the ISU-2 strain of IBR/IPV-herpes virus in inoculated cultures of bovine embryo kidney (BEK) cells.
abstract: Studies on the replication of the ISU-2 strain of IBR/IPV-Herpes virus and on its behaviour in inoculated BEK cultures have shown that the replication of viral DNA as well as the production of icosahedral particles occur within the cell nucleus. Similarly like in each Herpes virus group, while passing through the nuclear envelope and the cell membrane the virus obtains an additional envelope that enlarges its diameter. The viral particles produced in a large quantity, may pass through the cell membrane into the extracellular spaces or may be caught by the cytoplasmic vacoules, where they are decomposed.
mesh_terms: D002478:Cells, Cultured; D006564:Herpesviridae / Q000254:growth & development* / Q000648:ultrastructure; D014779:Virus Replication