Inhibition of arachidonic acid induced mortality in rabbits with several non-steroidal anti-inflammatory agents.
The intravenous administration of arachidonic acid to rabbits is an effective in vivo model for evaluating potential anti-thrombotic drugs. Most of the non-steroidal anti-inflammatory agents (NSAIFA) inhibit this arachidonic acid induced mortality (except sodium salicylate and acetaminophen). However, there is a lack of correlation between the relative potencies from various assays (rabbit anti-thrombotic, anti-inflammatory, alalgesic, ulcerogenic and inhibition of prostaglandin synthetase evaluations). These studies imply other actions with NSAIFA than an effect solely on the prostaglandin biosynthetic pathway.
D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology*; D001095:Arachidonic Acids / Q000037:antagonists & inhibitors* / Q000633:toxicity; D007928:Lethal Dose 50; D008297:Male; D011453:Prostaglandins / Q000096:biosynthesis; D011817:Rabbits
D000893:Anti-Inflammatory Agents; D001095:Arachidonic Acids; D011453:Prostaglandins