[Mechanisms of release of adrenaline and noradrenaline from the caudal mesenteric ganglion of dogs].
Adrenaline (A) and noradrenaline (N) release from the caudal mesenteric ganglion (CMG) during preganglionic nerve stimulation is due to acetylcholine action on N--and M-cholinoreceptors of ganglion's adrenergic structures (GAS) and probably, primarily on SIF--cells, whereas during peripheral reflexes of CMG it is related to the excitation of noncholinergic afferent neurons which affect the corresponding receptors of GAS. A and N release is inhibited via M-receptors. There is a complex relationship between receptor fields of GAS. Hemicholinium as well as N--cholinoblocking agents, during first minutes of their application to the ganglion elicit A and N release both before and after preganglionic fiber degeneration, which indicates their postsynaptic effect on the cholinoreceptors. Changes in A and N in the ganglion during peripheral reflexes are increased after prolonged action of hemicholinium and chronic decentralisation of CMG.
D000109:Acetylcholine / Q000494:pharmacology; D000818:Animals; D001338:Autonomic Fibers, Postganglionic / Q000502:physiology; D001339:Autonomic Fibers, Preganglionic / Q000502:physiology; D004285:Dogs; D004558:Electric Stimulation; D004837:Epinephrine / Q000378:metabolism*; D005725:Ganglia, Autonomic / Q000378:metabolism*; D006426:Hemicholinium 3 / Q000494:pharmacology; D009388:Neostigmine / Q000494:pharmacology; D009638:Norepinephrine / Q000378:metabolism*; D011976:Receptors, Muscarinic; D011978:Receptors, Nicotinic
D011976:Receptors, Muscarinic; D011978:Receptors, Nicotinic; D006426:Hemicholinium 3; D009388:Neostigmine; D000109:Acetylcholine; D009638:Norepinephrine; D004837:Epinephrine
Mekhanizmy vydeleniia adrenalina i noradrenalina iz kaudal'nogo bryzheechnogo gangliia sobaki.