title: Morphologic alteration of Paranaplasma caudata following treatment of calves with oxytetracycline.
abstract: The morphologic features of Paranaplasma caudata were determined in whole blood, blood clots, and liver biopsy specimens after treating infected calves with oxytetracycline. Following staining of blood smears with new methylene blue, light microscopy showed that paranaplasma bodies in erythrocytes of treated calves were vacuolated, but tails were normal in appearance. By electron microscopic examination of parasitized erythrocytes of treated calves, paranaplasma bodies were found to be degenerated (aggregation of nucleoprotein granules in initial bodies and condensation and coalescence of initial bodies), but tails were normal. The identical degenerative changes of paranaplasma bodies and lack of alteration of tails were evident in erythrocytes in sinusoids of liver biopsy specimens from treated calves.
mesh_terms: D000710:Anaplasmataceae / Q000648:ultrastructure*; D000712:Anaplasmosis / Q000188:drug therapy / Q000382:microbiology*; D000818:Animals; D002417:Cattle; D002418:Cattle Diseases / Q000188:drug therapy / Q000382:microbiology*; D004912:Erythrocytes / Q000382:microbiology; D008099:Liver / Q000382:microbiology; D010118:Oxytetracycline / Q000627:therapeutic use*
chemical_list: D010118:Oxytetracycline