title: Subjective and physiologic effects of morphine, pentobarbital, and meprobamate.
abstract: These studies extend previous observations on the effects of pentobarbital on subjective states and postrotational nystagmus in postaddict subjects. Pentobarbital (150 mg) induced a degree of liking and an elevation of the morphine-benzedrine group (MBG) scale score equivalent to 24 mg of morphine. The effects of pentobarbital and meprobamate on postrotational nystagmus were studied using electro-oculography. Both drugs increased the frequency and prolonged the duration of postrotational nystagmus in a dose-related manner. Meprobamate was about 1/15 as potent as pentobarbital in enhancing postrotational nystagmus and producing signs of sedation.
mesh_terms: D004585:Electrooculography; D006801:Humans; D006993:Hypnotics and Sedatives; D008620:Meprobamate / Q000494:pharmacology*; D009020:Morphine / Q000494:pharmacology*; D010424:Pentobarbital / Q000494:pharmacology*; D012438:Saccades / Q000187:drug effects; D011795:Surveys and Questionnaires
chemical_list: D006993:Hypnotics and Sedatives; D009020:Morphine; D008620:Meprobamate; D010424:Pentobarbital