Derivatives of 3, 3-spirobi-5-methyltetrahydrofuranone-2 as potential neurotropic agents. Part I.
Starting from 3,3'-spirobi-5-bromomethyltetrahydrofuranone-2 (2) the amino derivatives 3a--g were obtained. The pharmacological examination showed that the new compounds are deprived of the hypnotic activity characteristic for 3,3'-spirobi-5-methyltetrahydrofuranone-2 (2) and behaved in most tests as tranquillizers.
D000818:Animals; D005663:Furans / Q000138:chemical synthesis / Q000494:pharmacology; D006993:Hypnotics and Sedatives / Q000494:pharmacology; D013141:Spiro Compounds / Q000138:chemical synthesis* / Q000494:pharmacology; D014149:Tranquilizing Agents / Q000138:chemical synthesis / Q000494:pharmacology
D005663:Furans; D006993:Hypnotics and Sedatives; D013141:Spiro Compounds; D014149:Tranquilizing Agents