[Effect of a beta-adrenergic blocking agent on erythropoietin production in the mouse (author's transl)].
The effects of the beta-adrenergic blocking agent (propranolol) on erythropoietin production in carbon monoxide intoxicated mice were studied. The raise in plasma erythropoietin after a 4 hour intoxication with carbon monoxide was 47% less in the propranolol treated group. A decrease of 65% in the endogenous erythropoietic response after 75 minutes of carbon monoxide intoxication was found in policithemic treated mice, as against the untreated ones. The tissue oxygen tension was reduced in the propranolol treated group. No changes was found in the hemoglobin oxygen affinity.
D000818:Animals; D002249:Carbon Monoxide Poisoning / Q000188:drug therapy / Q000378:metabolism; D004920:Erythropoiesis / Q000187:drug effects*; D004921:Erythropoietin / Q000096:biosynthesis*; D007504:Iron Radioisotopes; D051379:Mice; D008809:Mice, Inbred C3H; D010101:Oxygen Consumption; D010313:Partial Pressure; D011433:Propranolol / Q000378:metabolism / Q000494:pharmacology* / Q000627:therapeutic use
D007504:Iron Radioisotopes; D004921:Erythropoietin; D011433:Propranolol
Efecto de un bloqueador beta-adrenérgico sobre la producción de eritropoyetina en el ratón