[The effect of cytostatic therapy with vincristin sulphate on disaccarchidases of rat intestinal mucosa (author's transl)].
This report shows that appropriate doses of vincristin sulphate may decrease disaccharidase activities of intestinal mucosa. With the higher doses of the cytostatic drug, the drastic drop of enzyme activities is associated with morphological alterations of the mucosa; disacchardiase activities remain depressed at least for a couple of days even after full morphological restoration of the mucosa. Studies in man should reveal whether similar intestinal lesions occur due to therapeutic doses of vincristin sulphate.
D000818:Animals; D003864:Depression, Chemical; D004186:Disaccharidases / Q000378:metabolism*; D004305:Dose-Response Relationship, Drug; D004386:Duodenum / Q000201:enzymology / Q000473:pathology; D007413:Intestinal Mucosa / Q000187:drug effects* / Q000201:enzymology / Q000473:pathology; D007583:Jejunum / Q000201:enzymology; D008297:Male; D051381:Rats; D013393:Sucrase / Q000378:metabolism; D013997:Time Factors; D014750:Vincristine / Q000494:pharmacology*
D014750:Vincristine; D004186:Disaccharidases; D013393:Sucrase
Disaccharidasen der Dünndarmschleimhaut der Ratte unter zytostatischer Behandlung mit Vincristinsulfat