An assessment of the generation times of neuronal precursors in the sensory retina and subventricular zone of the newborn rat.
Generation times and the times for their respective phases were determined for neuronal precursors in the sensory retina and subventricular zone of the brain of newborn CD rats. These regions can be induced to form retinoblastoma and medulloepitheliomas, respectively, following injection of adenovirus-12. Through use of autoradiographic techniques, it was shown that the cell cycle duration in the subventricular zone was almost twice as long as in the sensory retinal layer. The G1 phase durations were found to account for the majority of the time difference.
D000256:Adenoviridae; D000818:Animals; D001345:Autoradiography; D001921:Brain / Q000166:cytology*; D001932:Brain Neoplasms / Q000209:etiology; D002455:Cell Division; D005134:Eye Neoplasms / Q000209:etiology; D008527:Medulloblastoma / Q000209:etiology; D008938:Mitosis; D051381:Rats; D012160:Retina / Q000166:cytology*; D012175:Retinoblastoma / Q000209:etiology; D013997:Time Factors; D014412:Tumor Virus Infections / Q000209:etiology*