Early biochemical response of pulmonary tissue to manganese dioxide.
The biochemical response of pulmonary tissue to MnO2 dust burden of 30 days duration was studied in rats. The activities of enzymes from isolated fractions of rat lungs were not significantly altered, even though manganese content was increased significantly in tissues remote from lungs, indicating translocation of the dust from its intrapulmonary location.
D000818:Animals; D004195:Disease Models, Animal; D004391:Dust; D008168:Lung / Q000201:enzymology / Q000378:metabolism / Q000473:pathology; D008297:Male; D008345:Manganese / Q000378:metabolism; D011009:Pneumoconiosis / Q000201:enzymology / Q000473:pathology; D011506:Proteins / Q000378:metabolism; D051381:Rats; D014018:Tissue Distribution
D004391:Dust; D011506:Proteins; D008345:Manganese