title: Regulation of mammalian protein synthesis in vivo. Protein synthesis in rat liver and kidney after the administration of sublethal doses of cyclohyximide.
abstract: Protein synthesis in vivo was studied at various times after the administration of sublethal doses of cycloheximide to rats. Cycloheximide caused an inhibition, followed by a dose-and time-dependent stimulation, of incorportation of labelled precursor into proteins of the liver and kidney. The stimulation of protein synthesis at 24h was not due to a change of precursor  pool or the specific radioactivity of the precursor used. During the stimulatory period, leucine incorporation into various cellular protein fractions varied; incorporation into total nuclear protein was the most affected.
mesh_terms: D000596:Amino Acids / Q000097:blood; D000818:Animals; D003513:Cycloheximide / Q000494:pharmacology*; D007668:Kidney / Q000378:metabolism*; D007930:Leucine / Q000378:metabolism; D008099:Liver / Q000378:metabolism*; D008297:Male; D014176:Protein Biosynthesis; D051381:Rats; D013347:Subcellular Fractions / Q000378:metabolism; D013997:Time Factors
chemical_list: D000596:Amino Acids; D003513:Cycloheximide; D007930:Leucine