title: Investigation of exocrine pancreatic function by continuous infusion of caerulein and secretin in normal subjects and in chronic pancreatitis.
abstract: Exocrine pancreatic function has been evaluated in 24 controls and 29 patients with confirmed chronic pancreatitis by continuous infusion (90 min) of synthetic caerulein, 100 ng/kg/h, plus GIH secretin, 1 CU/kg/h. Mean secretory values of the controls were comparable to those obtained by others using maximal doses of secretin and CCK. Unlike the controls, patients suffering from chronic pancreatitis demonstrated a progressive reduction in secretion during infusion. Thus, the comparison of responses for the final 30-min period gave much clearer and more complete discrimination between normal and abnormal pancreatic function than the preceding 30-min period.
mesh_terms: D000293:Adolescent; D000328:Adult; D001639:Bicarbonates / Q000378:metabolism; D002108:Ceruletide; D002908:Chronic Disease; D002918:Chymotrypsin / Q000378:metabolism; D005260:Female; D006801:Humans; D007275:Injections, Intravenous; D008049:Lipase / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D010179:Pancreas / Q000378:metabolism*; D010195:Pancreatitis / Q000503:physiopathology*; D012633:Secretin / Q000008:administration & dosage; D012636:Secretory Rate / Q000187:drug effects; D014357:Trypsin / Q000378:metabolism
chemical_list: D001639:Bicarbonates; D012633:Secretin; D002108:Ceruletide; D008049:Lipase; D002918:Chymotrypsin; D014357:Trypsin