[Renal prostaglandins in DOCA-sodium chloride-induced hypertension in rats].
The changes in arterial pressure, sodium excretion, diuresis, and content of renal prostaglandins were studied in rats with COD-salt hypertension. The administration of DOC to rats with unilateral nephrectomy resulted in more distinct hypertension than in those with both kidneys preserved. Arterial pressure elevation was accompanied by a gradual reduction of renal prostaglandins concentration, the removal of one kidney causing an earlier and more distinct reduction of their content. Unilateral nephrectomy (without DOC administration) resulted in a reduction of prostaglandins concentration in the remaining kidney, but their total content in the medullar layer of this kidney practically did not change.
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D003900:Desoxycorticosterone; D004231:Diuresis / Q000187:drug effects; D006977:Hypertension, Renal / Q000139:chemically induced / Q000503:physiopathology*; D007668:Kidney / Q000503:physiopathology*; D008297:Male; D009392:Nephrectomy; D011453:Prostaglandins / Q000378:metabolism*; D051381:Rats; D012964:Sodium / Q000652:urine; D012965:Sodium Chloride / Q000494:pharmacology
D011453:Prostaglandins; D003900:Desoxycorticosterone; D012965:Sodium Chloride; D012964:Sodium
Pochechnye prostaglandiny pri DOKA-solevoĭ gipertonii u krys