[Modifications of sleep "in utero" in guinea pig after maternal administration of alpha-methyl-L-DOPA (author's transl)].
Effects of maternal administration of alpha-methyl-L-DOPA on sleep in utero were studied by polygraphic method in Guinea Pig faetus from the 53th day of gestation. Maternal injection of alpha-methyl-L-DOPA (100 and 200 mg/kg) produces a typical sedative effect on the faetus from the first hour after drug administration. But, effects appear attenuated in comparison to those of the new-born Guinea Pig: a paradoxical sleep-deprivation of only 30% is observed during the 12 hours period after drug injection. Causes of the attenuation in utero of these drug effects are discussed.
D000818:Animals; D005260:Female; D005333:Fetus / Q000187:drug effects*; D006168:Guinea Pigs; D008431:Maternal-Fetal Exchange; D008750:Methyldopa / Q000008:administration & dosage / Q000494:pharmacology*; D011247:Pregnancy; D012890:Sleep / Q000187:drug effects*
D008750:Methyldopa
Modifications du sommeil "in utero" chez le cobaye après administration d'alpha-méthyl-DOPA a la mère.