title: [Effects of dimethylsulfoxide and salicine on the delayed adaption on sorbose and dulcitol of Salmonellae (author's transl)].
abstract: Among the majority of Salmonella strains splitting sorbose or dulcitol with delay dimethylsulfoxide shortens the latent period preceding acid formation and abolishes the deceleration of sorbose adaption caused by salicine. In other strains, especially S. paratyphi B cultures, DMSO doesn't touch sorbose adaption directly but amplifies the restraing effect of salicine. From the whole of our findings it can be concluded that in the first group of strains sorbose adaption starts with segregation of adaptive sorbose permease positive mutants, followed by the - salicin-sensitive - induction of this permease, the appearance of mutants aditionally metabolizing sorbose constitutively, and, finally, the substrate-promoted particular growth of adapted cells. The latter category of strains, however, apparently possesses a wild type (constitutive or adaptive?) sorbose permease but splits off mutants with adaptive metabolizing enzymes the induction of which is salicine-sensitive. The amplification of the salicine effect by DMSO found in these strains might be refered to an enhancement of salicine uptake caused by DMSO.
mesh_terms: D000222:Adaptation, Physiological / Q000187:drug effects; D004121:Dimethyl Sulfoxide / Q000494:pharmacology*; D004376:Galactitol / Q000494:pharmacology*; D006027:Glycosides / Q000494:pharmacology*; D009154:Mutation / Q000187:drug effects; D012475:Salmonella / Q000187:drug effects* / Q000235:genetics / Q000378:metabolism / Q000502:physiology; D013013:Sorbose / Q000494:pharmacology*; D013402:Sugar Alcohols / Q000494:pharmacology*; D013997:Time Factors
chemical_list: D006027:Glycosides; D013402:Sugar Alcohols; D004376:Galactitol; D013013:Sorbose; D004121:Dimethyl Sulfoxide
vernacular_title: Wirkungen von Dimethylsulfoxid und Salicin auf die verzögerte Sorbose- und Dulcit-Anpassung der Salmonellen.