Cortisol stimulation of parathyroid hormone secretion by rat parathyroid glands in organ culture.
Addition of cortisol (10(-6) to 10(-8) M) and related glucocorticoid congeners to cultures of rat parathyroid glands stimulated dose-related increases in parathyroid hormone secretion; the addition of deoxycorticosterone or cortexolone was without effect. Cortexolone, however, inhibited the stimulatory activity of cortisol when both were added to the culture medium. This direct stimulatory effect of cortisol on parathyroid gland secretion may account in part for the increased concentration of parathyroid hormone in the serum of cortisol-treated animals.
D000596:Amino Acids / Q000378:metabolism; D000818:Animals; D001692:Biological Transport / Q000187:drug effects; D002118:Calcium / Q000494:pharmacology; D003345:Corticosterone / Q000494:pharmacology; D003907:Dexamethasone / Q000494:pharmacology; D006854:Hydrocortisone / Q000494:pharmacology*; D008297:Male; D009924:Organ Culture Techniques; D010280:Parathyroid Glands / Q000187:drug effects* / Q000378:metabolism; D010281:Parathyroid Hormone / Q000096:biosynthesis / Q000378:metabolism*; D051381:Rats; D012636:Secretory Rate / Q000187:drug effects
D000596:Amino Acids; D010281:Parathyroid Hormone; D003907:Dexamethasone; D002118:Calcium; D003345:Corticosterone; D006854:Hydrocortisone