Comparison in mice of the amnestic effects of cycloheximide and 6-hydroxydopamine in a one-trial passive avoidance task.
To test further the hypothesis that cycloheximide (CXM)-induced amnesia is due in part to its effects on the central adrenergic system, a comparison was made in mice of the effects of the antibiotic and of 6-hydroxydopamine (6-OHDA) on memory of a one-trial passive avoidance task. Both drugs produced anmesia 24 hr after training but unlike CXM, 6-OHDA had no effect on memory 20 min after training.
D000818:Animals; D001362:Avoidance Learning / Q000187:drug effects*; D001923:Brain Chemistry / Q000187:drug effects; D003513:Cycloheximide / Q000494:pharmacology*; D003864:Depression, Chemical; D004298:Dopamine / Q000032:analysis; D006892:Hydroxydopamines / Q000494:pharmacology*; D008297:Male; D008568:Memory / Q000187:drug effects*; D051379:Mice; D008810:Mice, Inbred C57BL; D009638:Norepinephrine / Q000032:analysis
D006892:Hydroxydopamines; D003513:Cycloheximide; D004298:Dopamine; D009638:Norepinephrine