Abnormally soluble collagen produced in fibroblasts cultures.
Abnormally soluble collagen is synthesized in vitro not only by skin fibroblasts of Marfan patients but also by those of patients with Ehlers-Danlos type V and cutis laxa. The excessive solubility of collagen is corrected by the addition to the culture medium of a synthetic flavonoid, (+)- catechin.
D001578:Benzopyrans / Q000494:pharmacology; D002478:Cells, Cultured; D003094:Collagen / Q000378:metabolism*; D003483:Cutis Laxa / Q000378:metabolism*; D004535:Ehlers-Danlos Syndrome / Q000378:metabolism*; D005347:Fibroblasts / Q000378:metabolism*; D006801:Humans; D006909:Hydroxyproline / Q000378:metabolism; D008382:Marfan Syndrome / Q000378:metabolism*; D012867:Skin
D001578:Benzopyrans; D003094:Collagen; D006909:Hydroxyproline