The influence of age on the renal response to water deprivation in man.
Alterations in urine concentrating ability with age were examined in 98 active community-dwelling volunteers (aged 20-79 years) who were free from evidence of diseases known to adversely affect renal function. There was a significant decrease in urine osmolality reached after 12 h dehydration with advancing age, which could not be correlated with the age-related decline in creatinine clearance. A significant age-related diminution in the ability to conserve solute was also observed. This inability to conserve solute may result in diminished medullary tonicity and impaired urinary concentrating ability.
D000328:Adult; D000368:Aged; D000375:Aging; D003404:Creatinine; D005919:Glomerular Filtration Rate; D006801:Humans; D007668:Kidney / Q000502:physiology*; D007671:Kidney Concentrating Ability; D008875:Middle Aged; D009994:Osmolar Concentration; D014554:Urination; D014868:Water Deprivation
D003404:Creatinine