Glucose-6-phosphate dehydrogenase deficiency and lobar pneumonia. Fine structure of the liver.
Ultrastructural changes appeared in liver biopsy specimens from eight patients with glucose-6-phosphate dehydrogenase deficiency who developed jaundice during the course of lobar pneumonia. The observed changed indicate that the hyperbilirubinemia and jaundice that develop in patients with glucose-6-phosphate dehydrogenase deficiency with lobar pneumonia are caused partly by hemolysis and partly by intrahepatic cholestasis. The cholestasis may be caused by a genetic predisposition in enzyme-deficient individuals; the hemolysis may be induced by pulmonary infection in individuals with an enzyme deficiency.
D002196:Capillaries / Q000648:ultrastructure; D002467:Cell Nucleus / Q000648:ultrastructure; D002779:Cholestasis / Q000150:complications; D004721:Endoplasmic Reticulum / Q000648:ultrastructure; D005955:Glucosephosphate Dehydrogenase Deficiency / Q000150:complications / Q000473:pathology*; D006801:Humans; D007501:Iron / Q000378:metabolism; D007565:Jaundice / Q000150:complications / Q000473:pathology; D007728:Kupffer Cells / Q000648:ultrastructure; D008099:Liver / Q000098:blood supply / Q000378:metabolism / Q000473:pathology*; D008112:Liver Glycogen / Q000378:metabolism; D008930:Mitochondria, Liver / Q000648:ultrastructure; D010587:Phagocytosis; D011018:Pneumonia, Pneumococcal / Q000150:complications* / Q000473:pathology
D008112:Liver Glycogen; D007501:Iron