Prostaglandins, indomethacin and dysmenorrhea.
Uterine contractility was recorded during the period of menstruation in six dysmenorrheic women. A variable high tonus was observed in each case. Uterine recordings were repeated during the subsequent menstruation following pre-treatment with indomethacin at an oral dose of 75 mg or 200 mg per day beginning one day before the expected onset of menstruation. A lower uterine tonus was found in all indomethacin-treated cycles. Complete alleviation of spasmodic pain was obtained in the six subjects. The endogenous concentration of 15-keto-13, 14-dihydro PGF2alpha was determined by the gas chromatography-mass spectrometry method and observed to be relatively high in women with dysmenorrhea.
D003967:Diarrhea / Q000139:chemically induced; D004412:Dysmenorrhea / Q000188:drug therapy* / Q000503:physiopathology; D005260:Female; D006801:Humans; D007213:Indomethacin / Q000009:adverse effects / Q000494:pharmacology / Q000627:therapeutic use*; D008598:Menstruation; D009325:Nausea / Q000139:chemically induced; D011460:Prostaglandins F / Q000097:blood*; D014590:Uterine Contraction / Q000187:drug effects*; D014839:Vomiting / Q000139:chemically induced
D011460:Prostaglandins F; D007213:Indomethacin