Dermatopharmacology of salicylic acid. III. Topical contra-inflammatory effect of salicylic acid and other drugs in animal experiments.
The acute contra-inflammatory effects of salicylic acid, three standard dermatocorticoids and four contact antiphlogistics have been investigated by means of a UV dermatitis inhibition test in the guinea pig. The substances tested had a distinct inhibitory effect on the development of erythema and can be ranked in the following ascending order of activity (percent of maximum possible score): bufexamac = 36%, salicylic acid = 37%, hydrocortisone = 44%, acetylsalicylic acid = 48%, flumethasone pivalate = 51%, fluocinolone acetonide = 51%, phenylbutazone = 56%, and indomethacin = 58%.
D000287:Administration, Topical; D000818:Animals; D001241:Aspirin / Q000008:administration & dosage / Q000627:therapeutic use; D002019:Bufexamac / Q000008:administration & dosage / Q000627:therapeutic use; D003872:Dermatitis / Q000188:drug therapy*; D005443:Flumethasone / Q000008:administration & dosage / Q000627:therapeutic use; D005446:Fluocinolone Acetonide / Q000008:administration & dosage / Q000627:therapeutic use; D006168:Guinea Pigs; D006854:Hydrocortisone / Q000008:administration & dosage / Q000627:therapeutic use; D007213:Indomethacin / Q000008:administration & dosage / Q000627:therapeutic use; D008297:Male; D010653:Phenylbutazone / Q000008:administration & dosage / Q000627:therapeutic use; D012459:Salicylates / Q000008:administration & dosage / Q000627:therapeutic use*
D012459:Salicylates; D005446:Fluocinolone Acetonide; D002019:Bufexamac; D010653:Phenylbutazone; D005443:Flumethasone; D001241:Aspirin; D006854:Hydrocortisone; D007213:Indomethacin