Pregnancy following 2-bromo-alpha-ergocryptine (CB-154)-induced ovulation in an acromegalic patient with galactorrhea and amenorrhea.
An acromegalic patient with galactorrhea-amenorrhea who conceived following long-term 2-bromo-alpha-ergocryptine (CB-154) therapy is described. During CB-154 therapy, determinations of serum prolactin (PRL), luteinizing hormone (LH)-human chorionic gonadotropin, follicle-stimulating hormone a reduction in PRL level followed by an LH peak, a rise in basal body temperature and menstruation. The patient became pregnant during the next cycle, but therapeutic abortion was performed because of the active acromegaly. These results demonstrate that CB-154 can restore ovulatory function not only to the patient with a hypothalamic disorder but also to the acromegalic patient with an enlarged sella turcica.
D000172:Acromegaly / Q000150:complications*; D000328:Adult; D000568:Amenorrhea / Q000097:blood / Q000150:complications* / Q000188:drug therapy; D001971:Bromocriptine / Q000494:pharmacology* / Q000627:therapeutic use; D006063:Chorionic Gonadotropin / Q000097:blood; D005260:Female; D005640:Follicle Stimulating Hormone / Q000097:blood; D005687:Galactorrhea / Q000097:blood / Q000150:complications* / Q000188:drug therapy; D013006:Growth Hormone / Q000097:blood; D006801:Humans; D007775:Lactation Disorders / Q000150:complications*; D007980:Levodopa / Q000627:therapeutic use; D007986:Luteinizing Hormone / Q000097:blood; D010060:Ovulation / Q000187:drug effects*; D011247:Pregnancy; D011248:Pregnancy Complications / Q000097:blood; D011388:Prolactin / Q000097:blood
D006063:Chorionic Gonadotropin; D001971:Bromocriptine; D007980:Levodopa; D011388:Prolactin; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone; D013006:Growth Hormone