Ethchlorvynol (Placidyl)-induced pulmonary edema.
Two patients experienced severe nonhemodynamic pulmonary edema following the intravenous injection of 25 and 40 mg/kg of body weight of ethchlorvynol (Placidyl). The pulmonary edema cleared rapidly. Injection of Placidyl (12 to 80 mg/kg of body weight) intravenously into dogs caused acute, severe, nonhemodynamic pulmonary edema (as evidenced by markedly elevated lung weights and microscopic evidence of intra-alveolar edema), hypotension with a relative bradycardia, and a decreased cardiac output. Injection of polyethylene glycol, the vehicle in which ethchlorvynol is diluted, did not reproduce the syndrome.
D000328:Adult; D000818:Animals; D004195:Disease Models, Animal; D004285:Dogs; D004305:Dose-Response Relationship, Drug; D004984:Ethchlorvynol / Q000008:administration & dosage / Q000494:pharmacology / Q000506:poisoning*; D005260:Female; D006439:Hemodynamics / Q000187:drug effects; D006801:Humans; D007275:Injections, Intravenous; D008168:Lung; D008297:Male; D009929:Organ Size; D011092:Polyethylene Glycols / Q000494:pharmacology; D011654:Pulmonary Edema / Q000139:chemically induced*; D019966:Substance-Related Disorders
D011092:Polyethylene Glycols; D004984:Ethchlorvynol