The effect of angiotensin II and indomethacin on immunoreactive prostaglandin "A" levels in man.
The effect of angiotensin II on peripheral levels of immunoreactive prostaglandin A2 (IR-PGA) was determined in 17 normal male volunteers. IR-PGA rose from 338 +/-65 (SE) pg/ml to 635+/-142 in response to pressor infusions of angiotensin II (p less than 0.05 on paired analysis). This increase was not observed when indomethacin, 75 mg p.o., was given to 8 patients two hours prior to a repeat infusion. Five patients of the original group were placed on a low sodium diet (10-20 mEg). The response to angiotensin was now exaggerated (278+/-52 pg/ml to 916+/-284). These five patients were kept on a low sodium intake and given indomethacin 50 mg p.o. g 6 hourly for 4 days. There was no significant rise with angiotensin infusion (106+/-31 pg/ml to 120+/-70). Pressor infusions of angiotensin II raise peripheral levels of IR-PGA, and this response is exaggerated by a low sodium diet and blocked by either acute or chronic indomethacin administration. This data supports the concept that vasodilatory prostaglandins may be released by endogenous angiotensin and thus provide a dynamic antagonism to the renin angiotensin system in man.
D000804:Angiotensin II / Q000494:pharmacology*; D004039:Diet, Sodium-Restricted; D004347:Drug Interactions; D006801:Humans; D007213:Indomethacin / Q000494:pharmacology*; D008297:Male; D011454:Prostaglandins A / Q000097:blood*
D011454:Prostaglandins A; D000804:Angiotensin II; D007213:Indomethacin