title: Etomidate: an ultrashort-acting nonbarbiturate agent for anesthesia induction.
abstract: Clinical evaluation of etomidate, an ultrashortacting nonbarbiturate hypnotic agent, shows it to be useful for anesthetic induction in adults. It produces sleep in 1 arm-brain circulation time, metabolites apparently peaking at 7 minutes postinjection. Cardiovascular and respiratory systems appear minimally affected and there is no indication of organ toxicity or other biochemical or hematologic drug-induced disturbances. Moderate pain on injection at some sites and transient myoclonia were the principal disadvantages observed.
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000777:Anesthetics / Q000008:administration & dosage / Q000009:adverse effects; D006801:Humans; D007093:Imidazoles / Q000008:administration & dosage / Q000009:adverse effects; D007267:Injections; D008297:Male; D008875:Middle Aged; D009207:Myoclonus / Q000139:chemically induced; D013874:Thiopental; D013997:Time Factors
chemical_list: D000777:Anesthetics; D007093:Imidazoles; D013874:Thiopental