Effect of pregnenolone-16alpha-carbonitrile on the rat liver.
In female rats, pregnenolone-16alpha-carbonitrile [PCN (a known microsomal enzyme inducer)] augmented liver weight and significantly increased hepatic protein, total lipid, phospholipid and ATP concentrations. These changes were correlated with hepatic drug-metabolizing enzyme induction. PCN did not alter body weight, or water, ash, triglyceride and cholesterol levels in the liver, but caused a mild reduction of hepatic glycogen.
D000255:Adenosine Triphosphate / Q000378:metabolism; D000818:Animals; D005260:Female; D050356:Lipid Metabolism; D008099:Liver / Q000187:drug effects* / Q000378:metabolism; D008112:Liver Glycogen / Q000378:metabolism; D008862:Microsomes, Liver / Q000378:metabolism; D009929:Organ Size / Q000187:drug effects; D010743:Phospholipids / Q000378:metabolism; D011285:Pregnenolone Carbonitrile / Q000494:pharmacology*; D011506:Proteins / Q000378:metabolism; D051381:Rats
D008112:Liver Glycogen; D010743:Phospholipids; D011506:Proteins; D011285:Pregnenolone Carbonitrile; D000255:Adenosine Triphosphate