[Peculiarities of the action of protein positively reacting in the sedimentation test for cancer on the activity of glycolytic enzymes].
Blood serum of oncologic patients due to immunoglobulin involved in its composition, activates glycolysis in the soluble fraction of muscles when using starch, glycogen and glucose as substrates. The activation is registered under both aerobic and anaerobic conditions. When elucidating the immunoglobulin effect in a glycolytic chain under aerobic conditions it is shown that its activating effect in the incomplete incubation system is manifested with such glycolysis substrates as fructose-6-phosphate and 2-phosphoglyceric acid. Glycolysis activation with serum is insignificant or absent at all with the presence of glucose-6-phosphate, fructose-1,6-diphosphate, 3-phosphoglyceric aldehide, 3-phosphoglyceric acid, phosphoenolpyruvic acid, sodium pyruvate. Immunoglobulin isolated from the blood serum of oncologic patients does not affect the activity of purified preparations of hexokinase, glycerinaldehydephosphate dehydrogenase, lactate dehydrogenase under aerobic and anaerobic conditions. When using the air as a gas medium lactate dehydrogenase is activated by immunoglobulin. Lactate dehydrogenase activity under aerobic and anaerobic conditions is essentially lower than in the case when the air serves as a gas medium.
D000332:Aerobiosis; D000693:Anaerobiosis; D004789:Enzyme Activation; D006019:Glycolysis; D006801:Humans; D007136:Immunoglobulins / Q000378:metabolism*; D007700:Kinetics; D007770:L-Lactate Dehydrogenase / Q000378:metabolism; D009132:Muscles / Q000201:enzymology; D009369:Neoplasms / Q000276:immunology*
D007136:Immunoglobulins; D007770:L-Lactate Dehydrogenase
Osoblivosti diĭ bilka, shcho pozitivno reague v osadoviĭ reaktsiĭ na rak, na aktivnist' fermentiv glikolizu.