Intrathecal tolerance of metrizamide in chloralose anesthetized cats.
The water soluble radiopaque medium, metrizamide (Amipaque) was introduced into the lumbar subarachnoid space in chloralose anesthetized cats at a standard volume of 0.35 cc/kg in concentrations of 300 mgI/cc to 500 mgI/cc during EMG recording. These animals did not differ from controls which received cerebrospinal fluid under otherwise identical conditions; both groups usually showed some mild and occasional muscle fasciculations or mild spasms. Treatment with metrizamide appeared to be a less deleterious procedure than that using hyperosmotic sucrose (1.32 M) as judged from EMG records. In contrast, equivalent amounts of neglumine iothalamate produced frank convulsions in 7 of 15 cases and a range of hyperirritability in the remaining 8.
D000758:Anesthesia; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D002415:Cats; D002698:Chloralose; D003287:Contrast Media / Q000008:administration & dosage / Q000633:toxicity*; D005260:Female; D006339:Heart Rate / Q000187:drug effects; D007278:Injections, Spinal; D007463:Iodobenzoates / Q000633:toxicity*; D007482:Iothalamate Meglumine / Q000633:toxicity; D008297:Male; D008793:Metrizamide / Q000008:administration & dosage / Q000633:toxicity*; D012119:Respiration / Q000187:drug effects; D012640:Seizures / Q000139:chemically induced*; D013346:Subarachnoid Space
D003287:Contrast Media; D007463:Iodobenzoates; D002698:Chloralose; D008793:Metrizamide; D007482:Iothalamate Meglumine