title: Effects of d-amphetamine and chlordiazepoxide on positive conditioned suppression.
abstract: Six rats lever-pressed under a variable-interval 80-sec food reinforcement schedule. After responding had stabilized, an 8-sec tone terminating with food delivery was superimposed on the variable-interval schedule on the average once every five minutes without regard to the animal's behavior. This positive conditioned suppression procedure consistently reduced responding during the pre-food stimulus (tone). Neither d-amphetamine (0.5, 1.0, 2.0 mg/kg) nor chlordiazepoxide (7.5, 15, 30 mg/kg) significantly affected the relative suppression produced by the tone. Instead, both drugs produced generally non-selective effects, similarly affecting response rate in the presence and absence of the tone.
mesh_terms: D000818:Animals; D002707:Chlordiazepoxide / Q000494:pharmacology*; D003216:Conditioning, Operant / Q000187:drug effects*; D003913:Dextroamphetamine / Q000494:pharmacology*; D005508:Food Deprivation; D008297:Male; D051381:Rats; D012055:Reinforcement Schedule
chemical_list: D002707:Chlordiazepoxide; D003913:Dextroamphetamine