[Dynamics of lipid concentration changes in the livers of rats on biosatellites "Cosmos-605" and "Cosmos-782"].
Histological and histochemical investigation was carried out with rat liver specimens taken 9-11 h (from 6 rats), 24 (from 7 rats), 48 h (from 8 rats), and 25 (from 5 rats) and 27 days (from 7 rats) after the completion of 19.5- and 22.5-day of space bioflights in "Cosmos-605" and "Cosmos-782". The same number of specimens was investigated from corresponding models of the experiments carried out in the laboratory and from the control rats. The investigations demonstrated that in the rats sacrificed during the first two days, and in 25 and 27 days after the completion of the flight, no morphological changes developed in comparison with the control and with the animals from the laboratory experiments. Only some fluctuations in lipid content could be noticed in connection with the time of samples taking after the completion of the experiments. The greatest amount of lipids in the liver was observed in the rats sacrified 9-11 h after the completion of the flight, in 24 h the lipid level was still rather high, and in 48 h there was a tendency to their decrease. In 25 and 27 days the livers of the animals from the experimental group did not differ in their lipid content from those of the control animals. The changes in the lipid content observed in the liver during 8-48 h after the flight completion and during the period of afteraction indicate the reversibility of the adipose infiltration process, connected with lipid mobilization, dependent on stress-reaction.
D000818:Animals; D006651:Histocytochemistry; D050356:Lipid Metabolism; D008099:Liver / Q000378:metabolism*; D051381:Rats; D013026:Space Flight; D013997:Time Factors
Odinamike izmeneniĭ soderzhaniia lipidov v pecheni krys, éksponirovannykh na biosputnikakh "Kosmos-605" i "Kosmos-782".