Urinary metabolites of amixetrine in man and in the dog.
The urinary metabolites of N-(2-phenyl-2-isoamyloxy) ethyl-pyrrolidine-hydrochloride (amixetrine) studied in man and in the dog demonstrated a comparable mode of transformation of the drugs for both species. The principal metabolites of amixetrine isolated from urine and purified with the aid of chromatographic techniques were identified by IR, NMR and mass spectrometry. Untransformed amixetrine and (1,2-phenyl-1-hydroxy)ethylpyrrolidine were found in small quantities. In man, as in the dog, the principal metabolite coming from an omega-1-oxidation of the isoamyl chain corresponded to 2-phenyl-2-butoxy-(3-methyl-3-ol)ethyl-pyrrolidine.
D000328:Adult; D000818:Animals; D002849:Chromatography, Gas; D002855:Chromatography, Thin Layer; D004285:Dogs; D005260:Female; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D013058:Mass Spectrometry; D011759:Pyrrolidines / Q000652:urine*; D013055:Spectrophotometry, Infrared
D011759:Pyrrolidines; C012181:amixetrine