The hemolytic activity of heterocyclic n-alkyl amine oxides.
The N-alkyl derivatives of morpholine-, pyrrolidine-, piperidine- and perhydroasepine-N-oxides caused the rapid, temperature-dependent, hemolysis of human red blood cells. The most hemolytic were the amine oxides with alkyl groups having 14-18 carbon atoms.
D003497:Cyclic N-Oxides / Q000494:pharmacology*; D004910:Erythrocyte Membrane / Q000187:drug effects; D006460:Hemolysin Proteins; D006801:Humans; D009025:Morpholines / Q000494:pharmacology; D010880:Piperidines / Q000494:pharmacology; D011759:Pyrrolidines / Q000494:pharmacology
D003497:Cyclic N-Oxides; D006460:Hemolysin Proteins; D009025:Morpholines; D010880:Piperidines; D011759:Pyrrolidines