Protective effects of 3-hydroxy-3-methylglutaric acid in alcohol-induced lipemia.
Oral administration of l g of 3-hydroxy-3-methylglutaric acid (HMG) before the ingestion of whiskey and a fatty meal markedly reduced the elevation of serum triglycerides, beta-lipoproteins, phospholipids, and cholesterol in man. In rats receiving an ethanol and corn oil mixture, HMG also inhibited the increase in postprandial serum and liver lipids. A comparative study of HMG and nicotinic acid in rats showed that, therapeutically, 50 mg MHG/kg body weitht is equivalent to 200 mg nicotinic acid/kg body weight in offering almost total protection against lipemic effects of ethanol.
D000328:Adult; D000434:Alcoholic Beverages; D000818:Animals; D002784:Cholesterol / Q000097:blood / Q000378:metabolism; D000431:Ethanol; D005977:Glutarates / Q000494:pharmacology*; D006801:Humans; D006880:Hydroxy Acids / Q000494:pharmacology*; D006949:Hyperlipidemias / Q000139:chemically induced / Q000378:metabolism*; D050356:Lipid Metabolism; D008099:Liver / Q000187:drug effects / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D010743:Phospholipids / Q000097:blood / Q000378:metabolism; D051381:Rats; D014280:Triglycerides / Q000097:blood / Q000378:metabolism
D005977:Glutarates; D006880:Hydroxy Acids; D010743:Phospholipids; D014280:Triglycerides; D000431:Ethanol; D002784:Cholesterol