Sub-acute toxicity of xylitol in rats; absence of hepatotoxicity.
Some workers have suggested that 6 days xylitol administration to rats results in hepatic dysfunction. In our study xylitol was administered to rats by daily gastric intubation for a period of 14 days. Dose levels were 1.25, 2.5, 5 and 10 g/kg. During treatment (2, 5 and 14 days), animals were submitted to careful clinical examinations and to blood serum analysis related to hepatic functions. They were sacrificed after 2, 5, and 14 days treatment. In the 2 and 5 days treatment groups, main organs were submitted to histological study. This examination was only performed on liver in the 14 days treatment group. No evidence of hepatotoxicity was recorded. Serum levels of all parameters measured were within normal limits (including bilirubin and serum alkaline phosphatase (SAP). No anomalies were shown histologically.
D000818:Animals; D001835:Body Weight / Q000187:drug effects; D005260:Female; D008099:Liver / Q000187:drug effects* / Q000502:physiology / Q000503:physiopathology; D008111:Liver Function Tests; D008297:Male; D051381:Rats; D014993:Xylitol / Q000633:toxicity*
D014993:Xylitol