Potential antitumor agents: a cytotoxic cardenolide from Coronilla varia L.
An alcoholic extract of the seeds of Coronilla varia L. showed inhibitory activity against KB cells in culture and was fractionated through a series of partitions, column chromatography, and preparative layer chromatography to yield hyrcanoside, daphnoretin, scopoletin, and umbelliferone. Hyrcanoside was also tested in the PS mouse leukemia assay and showed borderline activity.
D000818:Animals; D000970:Antineoplastic Agents; D002297:Cardanolides / Q000302:isolation & purification / Q000494:pharmacology*; D007942:Leukemia, Experimental / Q000188:drug therapy; D010936:Plant Extracts / Q000032:analysis / Q000494:pharmacology*; D012639:Seeds
D000970:Antineoplastic Agents; D002297:Cardanolides; D010936:Plant Extracts