[Goodpasture's syndrome and nephrocalcinosis].
In comparison with literary data is reported on 3 young men with a Goodpasture syndrome. Immunohistologically in all cases a glomerulonephritis of the type of basal membrane antibodies was proved, in one patient also still 14 months after having reached the terminal stage of the renal insufficeincy. In every case the disease led to the dialytic treatment without the necessity of nephrectomies for commanding haemmorrhages of the lungs. The longest survival time was 3 years. -- In 1 patient within metastatic calcifications a pronounced nephrocalcinosis developed. Massive depositions of calcium were found in the basal membranes of the glomeruli and tubuli. It is discussed on the genesis of nephrocalcinosis, in which case a secondary hyperparathyrodism, an elevation of the calcium-phosphate-product, an alkalotic metabolic position as well as the dystrophic renal parenchyma of the rapidly progressing glomerulonephritis of Goodpasture's syndrome are taken into consideration.
D000293:Adolescent; D000328:Adult; D019867:Anti-Glomerular Basement Membrane Disease / Q000150:complications*; D001485:Basement Membrane / Q000276:immunology; D001862:Bone Resorption; D002114:Calcinosis / Q000209:etiology; D003165:Complement System Proteins; D006801:Humans; D006947:Hyperkalemia / Q000209:etiology; D006961:Hyperparathyroidism / Q000209:etiology; D007136:Immunoglobulins; D007674:Kidney Diseases / Q000209:etiology*; D007678:Kidney Glomerulus / Q000276:immunology; D008297:Male; D006435:Renal Dialysis
D007136:Immunoglobulins; D003165:Complement System Proteins
Goodpasture-Syndrom und Nephrokalzinose.