Penetration of tobramycin sulfate in the aqueous humor of the rabbit.
The intraocular penetration of tobramycin sulfate, a new aminoglycoside antibiotic, was evaluated in rabbits following subconjunctival injection. The mean tobramycin sulfate concentration in the aqueous humor 60 minutes after a single 5-mg dose was 5.5 mug/ml, as compared to a mean concentration of 6.7 mug/ml following a single 10-mg dose. These levels exceed the minimal inhibitory concentration (MIC) for most Pseudomonas species and a variety of other Gram-negative bacilli recovered from clinical infection. No anterior segment changes that may be attributed to the antibiotic could be demonstrated in the injected eye.
D000818:Animals; D000900:Anti-Bacterial Agents / Q000378:metabolism*; D001082:Aqueous Humor / Q000187:drug effects / Q000378:metabolism*; D003228:Conjunctiva; D004305:Dose-Response Relationship, Drug; D007267:Injections; D011817:Rabbits; D014031:Tobramycin / Q000097:blood / Q000378:metabolism* / Q000494:pharmacology
D000900:Anti-Bacterial Agents; D014031:Tobramycin