On the origin of substance P and glutamic acid decarboxylase (GAD) in the substantia nigra.
Knife cuts in the frontal plane separating the anterior part of the caudate-putamen from the globus pallidus resulted in marked decreases in substances P levels in the reticular part of the substantia nigra. More caudal knife cuts were required in order to effect maximal decreases in nigral glutamic acid decarboxylase levels. Thus, there is a clear anatomical dissociation between the striatal neurons which project to the reticular part of the substantia nigra and which contain SP, and the more caudally located GAD-containing striatal and pallidal neurons, all of which travel through the globus pallidus on their way to the substantia nigra.
D000818:Animals; D002262:Carboxy-Lyases / Q000096:biosynthesis*; D002421:Caudate Nucleus / Q000378:metabolism; D002540:Cerebral Cortex / Q000378:metabolism; D003342:Corpus Striatum / Q000378:metabolism; D005260:Female; D005917:Globus Pallidus / Q000378:metabolism; D005968:Glutamate Decarboxylase / Q000096:biosynthesis*; D011699:Putamen / Q000378:metabolism; D051381:Rats; D013373:Substance P / Q000096:biosynthesis*; D013378:Substantia Nigra / Q000201:enzymology / Q000378:metabolism*
D013373:Substance P; D002262:Carboxy-Lyases; D005968:Glutamate Decarboxylase