title: Precautionary note for use of bisulfite in pharmaceutical formulations.
abstract: The effect of sodium bisulfite on aspirin hydrolysis was studied at 40 degrees in the pH range of 6.5-7.5. Significant catalytic activity by the sulfite ion was observed. Second-order rate constants were calculated for this catalysis and compared to other buffer species. The sulfite ion was a much more efficient catalyst than acetate, phosphate, or carbonate.
mesh_terms: D000975:Antioxidants; D001241:Aspirin; D002384:Catalysis; D055598:Chemical Phenomena; D002621:Chemistry; D006868:Hydrolysis; D007700:Kinetics; D013447:Sulfites
chemical_list: D000975:Antioxidants; D013447:Sulfites; D001241:Aspirin