Alpha-flupenthixol-induced hyperactivity by chronic dosing in rats.
Socially reared and isolation-reared rats treated chronically since weaning with alpha-flupenthixol showed elevated levels of spontaneous locomotor activity compared with control treated rats. However, chronic apomorphine treatment had no effect on spontaneous locomotor activity. Chronic alpha-flupenthixol treatment enhanced stereotyped behaviour after 1.5 mg/kg d-amphetamine or 0.5 mg/kg apomorphine in the socially reared condition. 'Spontaneous stereotypies' were also observed in the chronic alpha-flupenthixol-treated animals. Chronic apomorphine treatment did not affect stereotyped responding. The results are discussed in terms of 'behavioural supersensitivity'.
D000818:Animals; D001058:Apomorphine / Q000494:pharmacology; D001835:Body Weight / Q000187:drug effects; D003913:Dextroamphetamine / Q000494:pharmacology; D005260:Female; D005475:Flupenthixol / Q000494:pharmacology*; D006801:Humans; D009043:Motor Activity / Q000187:drug effects*; D051381:Rats; D012931:Social Environment; D012934:Social Isolation; D013239:Stereotyped Behavior / Q000187:drug effects; D013268:Stimulation, Chemical; D013892:Thioxanthenes / Q000494:pharmacology*
D013892:Thioxanthenes; D005475:Flupenthixol; D001058:Apomorphine; D003913:Dextroamphetamine