[Model of a chronic Vibrio cholerae carrier based on gnotobiotic rats].
Germ-free monoflora (contaminated with nonpathogenic spore-bearing bacillus) and common albino rats (OFA) were infected with V. cholera El Tor, of Ogava and Inaba serological types (6 milliard microbial cells per 1.5 ml of physiological solution per rat). Approximately one week after the infection the number of vibrios reached hundreds of millions per 1 g of feces and persisted at this level for over 100 days (observation period). Newborn rats were infected by natural way from adult vibrio carriers and also became vibrio-carriers. The number of vibrios excretedby the animals which were germ-free and monoflora before the infection was approximately the same. Cholera vibrios perished completely in the enteric tract and were never revealed in the feces of common (control) rats.
D000818:Animals; D002353:Carrier State; D002771:Cholera; D004195:Disease Models, Animal; D005856:Germ-Free Life; D051381:Rats
Model' khronicheskogo kholernogo vibriononostiel'stva na krysakh-gnotobiontakh