title: Intracranial calcifications in childhood leukemia. An association with systemic chemotherapy.
abstract: Children with acute lymphocytic leukemia were examined for evidence of intracranial calcifications with roentgenograms of the skull and computerized tomography. Of 39 children in their initial complete remission, ten were found to have subcortical cerebral calcifications. Significant associations were found between the presence of cerebral calcifications and systemic treatment with large cumulative doses of methotrexate.
mesh_terms: D000293:Adolescent; D001927:Brain Diseases / Q000139:chemically induced* / Q000000981:diagnostic imaging; D002114:Calcinosis / Q000139:chemically induced* / Q000000981:diagnostic imaging; D003561:Cytarabine / Q000009:adverse effects* / Q000627:therapeutic use; D006801:Humans; D007945:Leukemia, Lymphoid / Q000188:drug therapy*; D008727:Methotrexate / Q000009:adverse effects* / Q000627:therapeutic use; D011859:Radiography; D012075:Remission, Spontaneous
chemical_list: D003561:Cytarabine; D008727:Methotrexate