title: Ineffectiveness of heparin treatment in burn shock in the guinea pig.
abstract: The cardiovascular and metabolic responses during burn shock were characterized in 10 guinea pigs burned to the xyphoid process for 3 s in boiling water. This produced a burn of approximately 70% of the body surface. Their responses were compared to the values obtained at corresponding times in a group of unburned controls (n=10). The effect of Heparin treatment on burn shock was evaluated in another group (n=8) of guinea pigs burned to the xyphoid process and injected subcutaneously with 50,000 U Heparin/kg immediately after being burned. In the burned, untreated (BUT) animals, cardiac output was reduced more than 50% at 15 mins post-burn, and cardiac output remained depressed for the  next 8 h. Mean arterial blood pressure was initially maintained in the BUT animals, but started to fall after 3 h. Heart rate, oxygen consumption and core temperature all decreased progressively in the BUT group. Hemoconcentration was evident in the BUT animals, and there was an elevation in the post-burn glucose and lactate levels, a decrease in pH, and no change in free fatty acids. Heparin treatment did not significantly modify 24-h survival, and the post-burn cardiovascular responses of the Heparin-treated animals were similar to those of the BUT animals. Metabolically, the Heparin-treated animals had a significant elevation in free fatty acids post-burn, but otherwise closely resembled the BUT animals.
mesh_terms: D000818:Animals; D001786:Blood Glucose; D002056:Burns / Q000188:drug therapy*; D002302:Cardiac Output; D004195:Disease Models, Animal; D005230:Fatty Acids, Nonesterified / Q000097:blood; D005260:Female; D006168:Guinea Pigs; D006339:Heart Rate; D006400:Hematocrit; D006493:Heparin / Q000494:pharmacology*; D007773:Lactates / Q000097:blood; D008297:Male; D010101:Oxygen Consumption; D012772:Shock, Septic / Q000188:drug therapy*
chemical_list: D001786:Blood Glucose; D005230:Fatty Acids, Nonesterified; D007773:Lactates; D006493:Heparin