Synthesis of 1-hydroxy and 1-acyloxypyrrolidin-2-ones.
A series of 1-hydroxypyrrolidin-2-ones (v) has been prepared by reduction of gamma-nitrocarboxylic acid esters with Zn dust in the presence of ammonium chloride. Acylation of compounds (v) gave the corresponding 1-acyloxypyrrolidin-2-ones (VI). None of the synthesized compounds showed any significant antiflammatory activity.
D000215:Acylation; D004952:Esters; D010084:Oxidation-Reduction; D011760:Pyrrolidinones / Q000138:chemical synthesis*; D013055:Spectrophotometry, Infrared
D004952:Esters; D011760:Pyrrolidinones