Membrane sialic acid and behaviour in vivo of rabbit "stress" macroreticulocytes.
Membranes of rabbit reticulocytes obtained by phenylhydrazine stimulation have a chemical composition different from that of normal erythrocytes; sialic acid/protein and cholesterol/protein ratios are in fact lower than normal. In vivo study of 51Cr-labelled reticulocytes show that these cells are quickly removed from blood and, after a short "homing" in liver, return to peripheral blood. During "homing" in the liver, the sialic acid/protein ratio seems to increase.
D000818:Animals; D001772:Blood Cell Count; D002784:Cholesterol / Q000097:blood; D002860:Chromium Radioisotopes; D004910:Erythrocyte Membrane / Q000378:metabolism*; D004912:Erythrocytes / Q000378:metabolism*; D006400:Hematocrit; D008099:Liver / Q000378:metabolism; D008297:Male; D010659:Phenylhydrazines; D011817:Rabbits; D012156:Reticulocytes / Q000187:drug effects / Q000378:metabolism*; D012794:Sialic Acids / Q000097:blood*; D013154:Spleen / Q000378:metabolism
D002860:Chromium Radioisotopes; D010659:Phenylhydrazines; D012794:Sialic Acids; D002784:Cholesterol