Effect of 6-hydroxydopamine pretreatment on spontaneous convulsions induced by barbital withdrawal.
Following withdrawal from chronic barbital administration, 6-hydroxydopamine pretreated rats show a greater number and an earlier onset of spontaneous convulsive seizures than do rats pretreated with the saline-ascorbic acid vehicle.
D000818:Animals; D001205:Ascorbic Acid; D001462:Barbital; D001463:Barbiturates; D001835:Body Weight / Q000187:drug effects; D004298:Dopamine / Q000378:metabolism; D006801:Humans; D006892:Hydroxydopamines / Q000494:pharmacology; D008297:Male; D009638:Norepinephrine / Q000378:metabolism; D051381:Rats; D012640:Seizures / Q000139:chemically induced*; D013375:Substance Withdrawal Syndrome; D019966:Substance-Related Disorders / Q000378:metabolism; D013687:Telencephalon / Q000187:drug effects / Q000378:metabolism
D001463:Barbiturates; D006892:Hydroxydopamines; D001462:Barbital; D001205:Ascorbic Acid; D004298:Dopamine; D009638:Norepinephrine