[Kinetics of the distribution of azabutyrone in the organism of rats].
Spectrophotometry was employed in enquiring into the pharmacokinetics of azabutyrone in the organs of rats. With its intravenous or peroral administration the drug was found to quickly penetrate the cerebral tissues of rats and to accumulate therein. A direct relation between the dosage, the azabutyrone concentration in the cerebral tissues and the duration of the antiphenamine effect was disclosed. The cataleptic action correlates well with the drug concentration in the brain. No correlation between the level of the drug in the brain and the intensity of thiopental sodium anesthesia is observed.
D000818:Animals; D001921:Brain / Q000378:metabolism*; D002090:Butyrophenones / Q000008:administration & dosage / Q000378:metabolism* / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D004347:Drug Interactions; D010879:Piperazines / Q000008:administration & dosage / Q000378:metabolism / Q000494:pharmacology; D051381:Rats; D013874:Thiopental / Q000494:pharmacology
D002090:Butyrophenones; D010879:Piperazines; C011672:azabutyrone; D013874:Thiopental
Kinentika raspredeleniia v organizme krys azabutirona