title: Cefuroxime - a new cephalosporin antibiotic.
abstract: Cefuroxime is a new broad spectrum cephalosporin antibiotic for administration by injection. It is stable to most beta-lactamases. It is active against gram-positive organisms, including penicillinase-producing staphylococci, and has wide activity against gram-negative bacilli including Enterobacter and many strains of indole-positive Proteus spp. The substance is also highly active against Haemophilus influenzae and Neisseria gonorrhoeae. Studies on human volunteers showed that it produced high, long-lasting blood levels with virtually complete recovery of unchanged antibiotic in the urine. No evidence of toxicity due to cefuroxime was found. Slight, short-lived pain followed intramuscular injection, and the compound was well tolerated intravenously.
mesh_terms: D001419:Bacteria / Q000187:drug effects; D001798:Blood Proteins / Q000378:metabolism; D002510:Cephalosporinase / Q000378:metabolism; D002511:Cephalosporins / Q000378:metabolism / Q000494:pharmacology / Q000633:toxicity; D004344:Drug Incompatibility; D005663:Furans / Q000494:pharmacology; D006801:Humans; D007700:Kinetics; D011485:Protein Binding
chemical_list: D001798:Blood Proteins; D002511:Cephalosporins; D005663:Furans; D002510:Cephalosporinase