[Physiology and biochemistry of streptomycetes. X. Biological degradation of paromomycin and alkaline phosphatase activity depending on antibiotic production by Streptomyces albus var. metamycinus nov. var].
After adding 14C-paromomycin to the fermentation broth we observed a varying course of decomposition of the antibiotic, which is dependent on the intensity of paromomycin biosynthesis running simultaneously. At a reduced rate of antibiotic biosynthesis, the activity of alkaline phosphatase is lower than with an increased rate of production. This applies for mycelium as well as for broth.
D000469:Alkaline Phosphatase / Q000378:metabolism*; D001673:Biodegradation, Environmental; D003470:Culture Media; D005285:Fermentation; D005947:Glucose / Q000378:metabolism; D010303:Paromomycin / Q000096:biosynthesis / Q000378:metabolism*; D013302:Streptomyces / Q000378:metabolism*
D003470:Culture Media; D010303:Paromomycin; D000469:Alkaline Phosphatase; D005947:Glucose
Physiologie und Biochemie der Streptomyceten. X. Biologischer Abbau des Paromomycins und Aktivität der alkalischen Phosphatase in Abhängigkeit von der Antibioticumbildung bei Streptomyces albus var. metamycinus nov. var.