[Bacterial flora and nitrite production in the stomach after gastroenterostomy. Experimental aspects of the pathogenesis of carcinoma in the operated stomach (author's transl)].
A gastroenterostomy without enteroanastomosis leads to a change in the bacterial flora of the stomach, where-by in particular the proportion of nitrite-decomposing bacteria, is enhanced. This results in an increase of nitrite concentration in the gastric fluid, which may possibly be accompanied by an augmented production of carcinogenic nitrosoamine. This latter aspect is considered with respect to the origin of carcinoma in the operated stomach. Since the reported changes will be largely prevented by a Roux-Y-gastroenterostomy, this should be taken into consideration for reconstruction of the alimentary tract after gastric surgery.
D000818:Animals; D005750:Gastric Juice / Q000378:metabolism*; D005763:Gastroenterostomy / Q000009:adverse effects; D008297:Male; D009573:Nitrites / Q000096:biosynthesis*; D009602:Nitrosamines / Q000096:biosynthesis; D051381:Rats; D013270:Stomach / Q000382:microbiology*; D013274:Stomach Neoplasms / Q000209:etiology
D009573:Nitrites; D009602:Nitrosamines
Bakterielle Besiedlung und Nitritbildung im Magen nach Gastroenterostomie. Experimentelle Aspekte zur Pathogenese des Carcinoms im operierten Magen.