Butyrophenones and brain serotonin metaboism.
The influence of butyrophenone derivatives on the level of serotonin and 5-hydroxyindoleacetic acid in various regions of brain of normal and pargyline-treated rats was investigated. The result indicate that all butyrophenone derivatives used decrease serotonin utilization in rat brain stem while they have smaller influence on this process in the other rat brain regions examined.
D000818:Animals; D001921:Brain / Q000187:drug effects / Q000378:metabolism*; D002090:Butyrophenones / Q000494:pharmacology*; D006897:Hydroxyindoleacetic Acid / Q000378:metabolism; D008297:Male; D010293:Pargyline / Q000494:pharmacology; D051381:Rats; D012701:Serotonin / Q000378:metabolism*
D002090:Butyrophenones; D012701:Serotonin; D006897:Hydroxyindoleacetic Acid; D010293:Pargyline