title: High pressure liquid chromatographic determination of saccharin in alcoholic products.
abstract: After preliminary cleanup, sodium saccharin can be quantitatively determined in wines and proprietary drugs by using high pressure liquid chromatography. The preliminary cleanup removes materials that cause column deterioration, loss of baseline stability, and interfering peaks. The average experimental error found in analyses of 6 wines for sodium saccharin content was 2.3% and the standard deviation was 0.01. In the analysis of 10 cough medicines and vitamin preparations, the difference between declared and experimental values for sodium saccharin averaged 5.7%. The recovery for the extraction process ranged from 97.8 to 101.6%.
mesh_terms: D000434:Alcoholic Beverages / Q000032:analysis; D004304:Dosage Forms; D000431:Ethanol; D004366:Nonprescription Drugs / Q000032:analysis; D012439:Saccharin / Q000032:analysis*
chemical_list: D004304:Dosage Forms; D004366:Nonprescription Drugs; D000431:Ethanol; D012439:Saccharin