Fletcher factor deficiency and myocardial infarction.
The case of a patient who, while being treated for an acute myocardial infarction, was found to have Fletcher factor deficiency with a Fletcher factor concentration of less than 1% of normal is described. Fletcher factor deficiency is associated with defects in several interrelated systems, including clotting, fibrinolysis and kinin generation, all of which play a role in the pathogenesis and evolution of infarction. The development of myocardial infarction in a patient who had severe Fletcher factor deficiency emphasizes the importance of alternate pathways for activation of these systems.
D000328:Adult; D001778:Blood Coagulation Disorders / Q000150:complications / Q000175:diagnosis*; D001779:Blood Coagulation Factors / Q000032:analysis; D004562:Electrocardiography; D006801:Humans; D007610:Kallikreins / Q000172:deficiency*; D008297:Male; D009203:Myocardial Infarction / Q000097:blood* / Q000175:diagnosis / Q000209:etiology; D011288:Prekallikrein / Q000172:deficiency*; D013925:Thromboplastin / Q000032:analysis
D001779:Blood Coagulation Factors; D013925:Thromboplastin; D011288:Prekallikrein; D007610:Kallikreins