[Effect of puromycin and cycloheximide on the course of audiogenic epileptic seizures in rats].
Puromycin was injected intraventricularly and cyclohexymid subcutaneously into rats with a hereditary predisposition to audiogenic epileptiform seizures. The injections inhibited the intensity of protein synthesis in the brain by 40 to 65%. Resistance to acoustic stimuli which appeared in 24% of the experimental animals did not correlate with the degree of protein synthesis inhibition in the brain.
D000161:Acoustic Stimulation; D000818:Animals; D001921:Brain / Q000378:metabolism; D003513:Cycloheximide / Q000627:therapeutic use*; D008297:Male; D009419:Nerve Tissue Proteins / Q000096:biosynthesis; D011691:Puromycin / Q000627:therapeutic use*; D051381:Rats; D011930:Reaction Time; D012640:Seizures / Q000209:etiology / Q000378:metabolism / Q000517:prevention & control*
D009419:Nerve Tissue Proteins; D011691:Puromycin; D003513:Cycloheximide
Vliianie puromitsina i tsiklogeksimida na techenie audiogennykh épilepticheskikh pripadkov u krys