Methadone and brain development.
The effect of maternally administered methadone hydrochloride (5 mg/kg) on brain development of offspring treated during gestation and/or lactation was studied in 21-day-old rats. Animals treated during gestation or lactation were the most severely affected, with reductions in brain weights (12% and 30%, respectively), and DNA values (50% and 34%, respectively) observed.
D000818:Animals; D001921:Brain / Q000254:growth & development*; D001923:Brain Chemistry; D004247:DNA / Q000032:analysis; D005260:Female; D005865:Gestational Age; D007774:Lactation; D008431:Maternal-Fetal Exchange; D008691:Methadone / Q000008:administration & dosage / Q000494:pharmacology*; D009929:Organ Size; D011247:Pregnancy; D051381:Rats
D004247:DNA; D008691:Methadone