[Experimental evaluation of therapeutic-prophylactic nutrition in exposure to acrylonitrile].
The purpose of the work was to study the prophylactic effect of a synthetic complete ration with an addition of L-cysteine in doses of 300 and 150 mg/kg and also investigation of the protective action exerted by 3 rations with varying content of protein (10, 18 and 30 per cent) and calorific value with a repeated and chronic inhalation of AAN in concentrations of 20 +/- 5 and 9 +/- 2.8 mg/m3. The effectiveness of the food rations under study was evaluated basically according to metabolic criteria. The metabolic indices were found to be the most sensitive ones and changing early following the effect of AAN. For this reason they may serve as criteria for not only assessing the noxious action of the poison, but also in devising the type of the medico-prophylactic dietary.
D000181:Acrylonitrile / Q000506:poisoning*; D000208:Acute Disease; D000818:Animals; D002908:Chronic Disease; D002940:Circadian Rhythm; D003545:Cysteine / Q000627:therapeutic use; D004035:Diet Therapy; D004044:Dietary Proteins / Q000008:administration & dosage; D004353:Drug Evaluation, Preclinical; D004781:Environmental Exposure; D007928:Lethal Dose 50; D008297:Male; D009570:Nitriles / Q000506:poisoning*; D051381:Rats; D013861:Thiocyanates / Q000652:urine; D013997:Time Factors
D004044:Dietary Proteins; D009570:Nitriles; D013861:Thiocyanates; D003545:Cysteine; D000181:Acrylonitrile
K otsenke lechebno-profilakticheskogo pitaniia pri vozdeĭstvii nitrila akrilovoĭ kisloty v éksperimente.