title: [Study of the allergic properties of medicinal preparations in experiments].
abstract: Materials of an experimental study on allergenic properties of prolonged-action sulfanilamides and their semi-products are presented. Investigations involved the use of express-methods with intradermal administration of the substance into the ear and introduction of the agents together with the Freind adjuvant into the hind paw pad of a guinea pig. Experiments ascertained satisfactory dermal-allergic responses to the introduction of allergens differing in their strength by employing the above methods, as express ones for primary evaluation tof allergenic properties of drugs and their semi-products in conducting toxicological investigations.
mesh_terms: D000818:Animals; D004342:Drug Hypersensitivity; D006168:Guinea Pigs; D007668:Kidney / Q000187:drug effects; D008099:Liver / Q000187:drug effects; D011724:Pyridazines / Q000633:toxicity*; D013154:Spleen / Q000187:drug effects; D013412:Sulfadimethoxine / Q000633:toxicity*; D013424:Sulfanilamides / Q000633:toxicity*
chemical_list: D011724:Pyridazines; D013424:Sulfanilamides; D013412:Sulfadimethoxine
vernacular_title: Izuchenie allergennykh svoĭstv lekarstvennykh preparatov v éksperimente