[False radioimmuno-assay of thyroxine and triiodothyronine in the presence of hormone-binding autoantibodies in serum (author's transl)].
Radioimmunoassay of thyroxine and triiodothyronine in a 14-year-old girl with primary hypothyroidism and nodular goitre as a result of Hashimoto's thyroiditis gave falsely low values due to the presence of hormone-binding antibodies. Such antibodies occur in Hashimoto's thyroiditis and thyroid carcinoma. Their presence requires special methods for determining these hormones.
D000293:Adolescent; D000917:Antibody Formation; D001323:Autoantibodies; D003951:Diagnostic Errors; D005189:False Positive Reactions; D005260:Female; D006044:Goiter, Nodular / Q000097:blood / Q000276:immunology*; D006801:Humans; D007037:Hypothyroidism / Q000097:blood / Q000276:immunology*; D011863:Radioimmunoassay; D013967:Thyroiditis, Autoimmune / Q000188:drug therapy; D013974:Thyroxine / Q000097:blood* / Q000627:therapeutic use; D014284:Triiodothyronine / Q000097:blood*
D001323:Autoantibodies; D014284:Triiodothyronine; D013974:Thyroxine
Radioimmunologische Fehlbestimmung von Thyroxin und Trijodthyronin bei Anwesenheit hormonbindender Autoantikörper im Serum