[Electron-microscopic study of changes in the myocyte ultrastructure under the effect of hyaluronidase in experimental myocardial infarct].
The myocardium of 60 rabbits with experimental myocardial infarction induced by ligation of the anterior interventricular branch of the left coronary artery was studied by electron microscopy. The main group of animals received hyaluronidase. The size of the infarct was judged by the ECG recorded with 15 precordial leads. Normalization of myocytes in the non-ischemic zone of the left ventricle in the treated animals revealed. Better intactness of myocytes in the peri-infarction and non-ischemic zones was noted, which may apparently accelerate ECG dynamics, change the total balance of necrotic material in the direction of its decrease, and, consequently, influence the indices of blood plasma creatine phosphokinase.
D000818:Animals; D004341:Drug Evaluation; D006821:Hyaluronoglucosaminidase / Q000627:therapeutic use*; D008297:Male; D008854:Microscopy, Electron; D009203:Myocardial Infarction / Q000188:drug therapy / Q000473:pathology*; D009206:Myocardium / Q000473:pathology / Q000648:ultrastructure*; D011817:Rabbits
D006821:Hyaluronoglucosaminidase
Elektronno-mikroskopicheskoe issledovanie izmeneniĭ ul'trastruktury miotsitov pod vliianiem gialuronidazy pri eksperimental'nom infarkte miokarda.