[The effect of clotrimazole on the pathogen of toxoplasmosis, Toxoplasma gondii].
By means of a toxoplasma infection in the mouse it was tested whether the antimycotic agent bis-phenyl-(2-chlorophenyl)-1-imidazolyl-methane (clotrimazol, Canesten¿) is also effective against the asexual stages of replication of T. gondii as they occur in man. Canesten did not influence the forms of the proliferative phase of replication of T. gondii (trophozoites, pseudocysts = tachyzoites) either in vivo in infected mice or in vitro in the tissue culture.
D000818:Animals; D003022:Clotrimazole / Q000494:pharmacology*; D046508:Culture Techniques; D007093:Imidazoles / Q000494:pharmacology*; D051379:Mice; D012100:Reproduction, Asexual / Q000187:drug effects; D014122:Toxoplasma / Q000187:drug effects*; D014124:Toxoplasmosis, Animal / Q000469:parasitology*
D007093:Imidazoles; D003022:Clotrimazole
Die Wirkung von Clotrimazol auf den Erreger der Toxoplasmose, Toxoplasma gondii