Observations of increased levels of blood coagulation factors and other plasma proteins in cholestatic liver disease.
One group of 8 patients with primary biliary cirrhosis and one group of 7 patients with common duct stone both had generally high levels of blood coagulation factors and a wide range of other plasma proteins. In contrast, one group of 6 patients with chronic active hepatitis generally had low levels of the same coagulation factors and plasma proteins. Analyses of factor II-VII-X, plasminogen, ceruloplasmin, beta1C/1A-globulin, IgG and IgM are especially helpful in the differentiation between primary biliary cirrhosis and chronic active hepatitis. The data are interpreted as suggesting a generally increased synthesis of liver-produced proteins in cholestasis, although more specific factors may modify the degree of increase of the individual proteins.
D000328:Adult; D000368:Aged; D001779:Blood Coagulation Factors / Q000032:analysis; D001798:Blood Proteins / Q000032:analysis; D002908:Chronic Disease; D005260:Female; D042882:Gallstones / Q000097:blood*; D006505:Hepatitis / Q000097:blood*; D006801:Humans; D008105:Liver Cirrhosis, Biliary / Q000097:blood*; D008297:Male; D008875:Middle Aged
D001779:Blood Coagulation Factors; D001798:Blood Proteins