Radiation necrosis of the brain following radiotherapy of extracerebral neoplasms.
Two patients developed necrosis of the brain 12-32 months subsequent to irradiation of extracerebral tumors. The pathology and probably pathogenesis are discussed. Craniotomy with excision of necrotic brain may be lifesaving.
D000238:Adenoma, Chromophobe / Q000532:radiotherapy; D001927:Brain Diseases / Q000209:etiology* / Q000473:pathology; D001929:Brain Edema / Q000209:etiology; D002277:Carcinoma / Q000532:radiotherapy; D002540:Cerebral Cortex / Q000473:pathology; D005260:Female; D006258:Head and Neck Neoplasms / Q000532:radiotherapy; D006801:Humans; D007049:Iatrogenic Disease; D008297:Male; D008875:Middle Aged; D009336:Necrosis / Q000209:etiology* / Q000473:pathology; D010911:Pituitary Neoplasms / Q000532:radiotherapy; D011832:Radiation Injuries; D011878:Radiotherapy / Q000009:adverse effects*; D012888:Skull Neoplasms / Q000532:radiotherapy