Quantitative aspects of transplantation of experimentally induced tumors of the nervous system.
Quantitative aspects of transplantation have been studied experimentally in ethylnitrosourea-induced nervous system tumors. The number of cells needed for successful transplantation, the biological behaviour-increase of malignancy-of the tumor in relation to the number of cells used during the various passages, and the relationship between number of grafted cells and induction time have been examined. A "critical" number of cells was necessary to ensure a positive result; thereafter, the induction time was directly related to the logarithm of the number of cells implanted.
D000818:Animals; D002452:Cell Count; D005038:Ethylnitrosourea; D005910:Glioma / Q000473:pathology; D009368:Neoplasm Transplantation; D009374:Neoplasms, Experimental / Q000139:chemically induced / Q000473:pathology*; D009422:Nervous System Diseases / Q000139:chemically induced / Q000473:pathology*; D051381:Rats; D013997:Time Factors; D014184:Transplantation, Homologous
D005038:Ethylnitrosourea