[Role of the hydrophobicity of polymethylene-bis-quaternary ammonium compounds in the mechanism of their curare-like action].
Lengthening of the N-alkyl radical (from--C2H5 to C10H21) in the series of polymethylene-bis-quaternary ammonium compounds was found to result in an increased hydrophobic properties of the compounds. In the presence of the N-butyl radical the mode of the action exerted by the substances changes, viz. from depolarizing they turn into antidepolarizing ones. A substitution of polyalicyclic radicals (cyclohexyl, 1-adamantyl) for methyl groups at the nitrogen atoms in the series of polymethylene-bis-quaternary ammonium compounds proved that in order to changed the mode of action hydrophobic properties of the cyclohexyl radicals appear to be good enough.
D000818:Animals; D001001:Anura; D004123:Dimethylamines / Q000494:pharmacology; D008968:Molecular Conformation
D004123:Dimethylamines
O roli gidrofobnosti polimetilen-bis-chetvertichnykh ammonievykh soedineniĭ v mekhanizme ikh kurarepodobnogo deĭstviia