Isolation of brevistin, a new peptide antibiotic. Studies on antibiotics from the genus Bacillus. IX.
A new peptide antibiotic, brevistin, was isolated from the culture broth of Bacillus brevis 342-14. Brevistin is an acylpeptide with an approximate empirical formula of C63H91N15O18 containing aspartic acid, threonine, glycine, valine, isoleucine, phenylalanine, tryptophan and 2,4-diaminobutyric acid. The antibiotic is soluble in acid and alkaline water. Its hydrochloride is soluble in methanol. Brevistin is active against Ggam-positive bacteria in vitro and in vivo, and is of low toxicity to mice.
D000818:Animals; D000900:Anti-Bacterial Agents / Q000096:biosynthesis / Q000302:isolation & purification / Q000494:pharmacology; D001407:Bacillus / Q000145:classification / Q000378:metabolism; D001419:Bacteria / Q000187:drug effects; D001424:Bacterial Infections / Q000188:drug therapy; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D005285:Fermentation; D007928:Lethal Dose 50; D051379:Mice; D008813:Mice, Inbred ICR; D010455:Peptides / Q000302:isolation & purification; D010456:Peptides, Cyclic / Q000096:biosynthesis / Q000494:pharmacology
D000900:Anti-Bacterial Agents; D010455:Peptides; D010456:Peptides, Cyclic