[Study of glucagon secretion in patients with hemochromatosis].
Diabetes in idiopathic hemochromatosis has been considered to be secondary to islet cell damage resulting from the iron deposits. Plasma glucagon was measured by immunoassay using the pancreas specific 30-K antiserum, and was found to be normal or slightly elevated during arginine-infusion tests in patients exhibiting both hemochromatosis and pathological glucose tolerance. This suggests that diabetes in hemochromatosis is not due to a lesion resulting from the iron deposits. The two affections appear to be merely associated and are possibly genetically linked.
D003920:Diabetes Mellitus / Q000209:etiology / Q000235:genetics; D005934:Glucagon / Q000378:metabolism*; D006432:Hemochromatosis / Q000235:genetics / Q000503:physiopathology*; D006801:Humans
D005934:Glucagon
Etude de la sécrétion de glucagon chez des patients atteints d'hémochromatose.