Ascorbic acid and cholesterol: effect of graded oral intakes on cholesterol conversion to bile acids in guinea-pigs.
A significant correlation between liver ascorbic acid (AA) and total bile acids or liver bile acids has been established in guinea-pigs by direct determination of the bile acids, confirming an earlier hypothesis. The oxidation of cholesterol to bile acids is dependent on the AA status, but it cannot be further stimulated by AA when the animals are already on an adequate intake of the vitamin. This suggests that AA has a hypocholesterolaemic effect over a limited range of AA status.
D000818:Animals; D001205:Ascorbic Acid / Q000378:metabolism* / Q000494:pharmacology*; D001206:Ascorbic Acid Deficiency / Q000378:metabolism*; D001647:Bile Acids and Salts / Q000378:metabolism*; D002784:Cholesterol / Q000378:metabolism*; D005230:Fatty Acids, Nonesterified / Q000097:blood; D005704:Gallbladder / Q000378:metabolism; D006168:Guinea Pigs; D007421:Intestine, Small / Q000378:metabolism; D008099:Liver / Q000187:drug effects / Q000378:metabolism*; D008297:Male; D009928:Organ Specificity; D014280:Triglycerides / Q000097:blood
D001647:Bile Acids and Salts; D005230:Fatty Acids, Nonesterified; D014280:Triglycerides; D002784:Cholesterol; D001205:Ascorbic Acid