title: [Synthesis and preliminary pharmacological characteristics of various derivatives of 1,2,5-oxadiazole (furazan)].
abstract: The synthesis, the chemical properties, the acute toxicity, the action of frog flexor reflex of 4-methylfurazan-3-N-methylcarboxamide (II), 4-methylfurazan-3-N-isopropylcarboxamide (III), 3-methyl-4-morpholinocarbonylfurazan (IV), 3-methyl-4-pyrrolidinocarbonylfurazan (V), 3-amino-4-methylfurazan (VI), 3-acetylamino-4-methylfurazan (VII), are reported. LD50 decrease in the following order: (VI), (II), (IV), (III), (VII), (V). All compounds, except (VII), depressed frog flexor reflexes.
mesh_terms: D000818:Animals; D001001:Anura; D007422:Intestines / Q000187:drug effects; D008099:Liver / Q000187:drug effects; D051379:Mice; D010069:Oxadiazoles / Q000138:chemical synthesis* / Q000494:pharmacology / Q000633:toxicity; D012018:Reflex / Q000187:drug effects
chemical_list: D010069:Oxadiazoles
vernacular_title: Sintesi e notizie preliminari farmacologiche di alcuni derivati dell'1,2,5-oxadiazolo (furazano).