Pharmacological properties of bis-beta-hydroxypropylmalonic acid dilactone derivatives.
Acute toxicity and the action on CNS (employing behavioural tests) of bis-beta-hydroxypropylmalonic acid dilactone (D1) and its four derivatives (D2--D5) were investigated (Table 1) in mice and rats. The studied compounds showed low toxicity and were sometimes active just from high doses. D1 can be regarded as a sedative--hypnotic compound. In animals, the substituted dilactones induced the symptoms similar to those of tranquilizers.
D000818:Animals; D001831:Body Temperature / Q000187:drug effects; D003216:Conditioning, Operant / Q000187:drug effects; D004347:Drug Interactions; D005260:Female; D006801:Humans; D008297:Male; D008314:Malonates / Q000494:pharmacology*; D051379:Mice; D008815:Mice, Inbred Strains; D009043:Motor Activity / Q000187:drug effects; D004856:Postural Balance / Q000187:drug effects; D051381:Rats; D012890:Sleep / Q000187:drug effects; D013239:Stereotyped Behavior / Q000187:drug effects; D013997:Time Factors
D008314:Malonates