title: [Research on monoamine oxidase inhibitors: synthesis of N-alkyl and N-aralkyl substituted ethylsyringoylhydrazides].
abstract: In continuation of previous work on compounds with anti-MAO activity, some alkyl and aralkyl-hydrazides of ethylsyringic acid (3,5-dimethoxy-4-ethoxybenzoic acid) were synthesized. Pharmacological examination showed that branching of the alkyl radical on the beta nitrogen to the carbonyl group increases anti-MAO activity which appears to be linked with the molecular dimensions of the alkyl group.
mesh_terms: D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D002560:Cerebrovascular Circulation / Q000187:drug effects; D005707:Gallic Acid / Q000031:analogs & derivatives* / Q000138:chemical synthesis; D006834:Hydrazines / Q000138:chemical synthesis* / Q000494:pharmacology; D008297:Male; D008996:Monoamine Oxidase Inhibitors / Q000138:chemical synthesis* / Q000494:pharmacology; D051381:Rats
chemical_list: D006834:Hydrazines; D008996:Monoamine Oxidase Inhibitors; D005707:Gallic Acid