[Studies on inhibition of platelet aggregation by carbocromen (author's transl)].
3-(2-Diethylaminoethyl)4-methyl-7-(carbethoxy-methoxy)-2-oxo-1,2-chromene-hydrochloride (carbocromen; Intensaïn) shows dose dependent platelet aggregation inhibitory activity in vitro according to the methods of Born (following ADP, epinephrine and collagen) and of Breddin (platelet agglutination test--PAT--, adhesively). The effect was found to be more pronounced than that of acetylsalicylic acid. Furthermore, in vivo carbocromen inhibited the increased spontaneous platelet aggregation in man.
D000244:Adenosine Diphosphate / Q000494:pharmacology; D000372:Agglutination Tests; D001241:Aspirin / Q000494:pharmacology; D002866:Chromonar / Q000008:administration & dosage / Q000494:pharmacology*; D003094:Collagen / Q000494:pharmacology; D003374:Coumarins / Q000494:pharmacology*; D003864:Depression, Chemical; D004305:Dose-Response Relationship, Drug; D006801:Humans; D007263:Infusions, Parenteral; D009391:Nephelometry and Turbidimetry; D010426:Pentosan Sulfuric Polyester / Q000494:pharmacology; D010973:Platelet Adhesiveness / Q000187:drug effects; D010974:Platelet Aggregation / Q000187:drug effects*; D013997:Time Factors
D003374:Coumarins; D010426:Pentosan Sulfuric Polyester; D000244:Adenosine Diphosphate; D003094:Collagen; D002866:Chromonar; D001241:Aspirin
Untersuchungen zur Hemmung der Thrombozytenaggregation durch Carbocromen