title: Cytochrome P-450-mediated oxidation of 2-hydroxyestrogens to reactive intermediates.
mesh_terms: D000332:Aerobiosis; D000693:Anaerobiosis; D000818:Animals; D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism*; D004958:Estradiol / Q000031:analogs & derivatives / Q000378:metabolism; D004967:Estrogens / Q000378:metabolism*; D004970:Estrone / Q000031:analogs & derivatives / Q000378:metabolism; D004997:Ethinyl Estradiol / Q000031:analogs & derivatives / Q000378:metabolism; D006914:Hydroxysteroids / Q000378:metabolism*; D008297:Male; D008862:Microsomes, Liver / Q000187:drug effects / Q000201:enzymology*; D010634:Phenobarbital / Q000494:pharmacology; D011285:Pregnenolone Carbonitrile / Q000494:pharmacology; D051381:Rats; D013482:Superoxide Dismutase / Q000494:pharmacology
chemical_list: D004967:Estrogens; D006914:Hydroxysteroids; D011285:Pregnenolone Carbonitrile; D004970:Estrone; D004997:Ethinyl Estradiol; D004958:Estradiol; D003577:Cytochrome P-450 Enzyme System; D013482:Superoxide Dismutase; D010634:Phenobarbital