title: Inhibition of acetylcholinesterase by derivatives of 1,3,2-dioxaphosphorinane 2-oxide.
abstract: Cholinesterases are inhibited by 2-fluoro-1,3,2-dioxaphosphorinane 2-oxide by a mechanism that involves a slow association step followed by a very slow phosphorylation step. No phosphorylation step was observed for the interaction between acetylcholinesterase and 2-S-[2'-(NN-diethylamino)ethyl]thio-1,3,2-dioxaphosphorinane 2-oxide.
mesh_terms: D002800:Cholinesterase Inhibitors / Q000494:pharmacology; D003498:Cyclic P-Oxides / Q000494:pharmacology; D007700:Kinetics; D009943:Organophosphorus Compounds / Q000494:pharmacology*
chemical_list: D002800:Cholinesterase Inhibitors; D003498:Cyclic P-Oxides; D009943:Organophosphorus Compounds