(Vinylaryloxy)acetic acids. A new class of diuretic agents. 4. Various ((2-substituted and 2,2-disubstituted vinyl)aryloxy)acetic acids.
A variety of [(2-substituted and 2,2-disubstituted vinyl)aryloxy]acetic acids was synthesized in which the substituents were primarily electron-withdrawing groups. These compounds were tested in dogs for their saluretic and diuretic properties. Many of the compounds exhibited significant activity; however, they were generally less potent than those reported in the three earlier papers in this series.
D000085:Acetates / Q000008:administration & dosage / Q000138:chemical synthesis* / Q000494:pharmacology; D000284:Administration, Oral; D000818:Animals; D002712:Chlorides / Q000652:urine; D004231:Diuresis / Q000187:drug effects; D004232:Diuretics / Q000008:administration & dosage / Q000138:chemical synthesis*; D004285:Dogs; D005260:Female; D007275:Injections, Intravenous; D011188:Potassium / Q000652:urine; D012964:Sodium / Q000652:urine; D013329:Structure-Activity Relationship; D014753:Vinyl Compounds / Q000008:administration & dosage / Q000138:chemical synthesis / Q000494:pharmacology
D000085:Acetates; D002712:Chlorides; D004232:Diuretics; D014753:Vinyl Compounds; D012964:Sodium; D011188:Potassium