Isolation of a new antibiotic, laterosporamine. Studies on antibiotics from the genus Bacillus. XIII.
A new antibiotic, named laterosporamine, was isolated from the culture broth of Bacillus laterosporus 340-19. The antibiotic is active against Gram-positive and Gram-negative bacteria in vitro and in vivo. It is a water-soluble basic substance, positive to ninhydrin, SAKAGUCHI'S and DRAGENDORFF'S reagents. A non-peptidic structure with an approximate empirical formula C17H35N7O4 was suggested.
D000818:Animals; D000900:Anti-Bacterial Agents / Q000032:analysis / Q000096:biosynthesis / Q000494:pharmacology; D001407:Bacillus / Q000378:metabolism; D001419:Bacteria / Q000187:drug effects; D001424:Bacterial Infections / Q000188:drug therapy; D055598:Chemical Phenomena; D002621:Chemistry; D051379:Mice; D008813:Mice, Inbred ICR; D014780:Viruses / Q000187:drug effects
D000900:Anti-Bacterial Agents