Inhibition of drug metabolism by fluoxetine.
Fluoxetine hydrochloride (Lilly 110140: 3-p-trifluoromethylphenoxy-3-phenyl-N-methyl-propylamine hydrochloride) inhibited the metabolism of hexobarbital and ethinamate in rodents and prolonged the hypnotic effects of these drugs.
D000818:Animals; D001923:Brain Chemistry / Q000187:drug effects; D002219:Carbamates / Q000494:pharmacology; D006591:Hexobarbital / Q000032:analysis / Q000494:pharmacology; D051379:Mice; D010647:Phenyl Ethers / Q000494:pharmacology; D011437:Propylamines / Q000494:pharmacology*; D012890:Sleep / Q000187:drug effects; D013997:Time Factors
D002219:Carbamates; D010647:Phenyl Ethers; D011437:Propylamines; D006591:Hexobarbital