Diuretic effect of furosemide in acute glomerulonephritis.
Twenty-five children with the diagnosis of acute glomerulonephritis were treated with oral or intravenous doses of furosemide. The intravenous administration of 1 mg/kg or greater resulted in an increase in urine volume in all patients. Oral doses of less than 2 mg/kg were not as effective, but there was wide variation in diuretic response to the drug. In 13 patients, plasma concentrations of furosemide were measured. The plasma half-life varied from 2.3 to 4.4 hours after intravenous administration of the drug. The plasma concentration of furosemide did not correlate with diuretic response.
D000208:Acute Disease; D000284:Administration, Oral; D000293:Adolescent; D001806:Blood Urea Nitrogen; D002648:Child; D002675:Child, Preschool; D004231:Diuresis / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D005665:Furosemide / Q000008:administration & dosage / Q000097:blood / Q000627:therapeutic use*; D005921:Glomerulonephritis / Q000097:blood / Q000188:drug therapy*; D006207:Half-Life; D006801:Humans; D007275:Injections, Intravenous
D005665:Furosemide