The effect of dimethylphenylpiperazinium on the amine uptake process.
Dimethylphenylpiperazinium (DMPP) potentiated the contractile response of rat isolated vas deferens to norepineprine and decreased that to tyramine. This action of DMPP is explained by the observation that it inhibited the uptake of 3H-norepinephrine and 3H-tyramine into adrenergic nerve terminals.
D000818:Animals; D004246:Dimethylphenylpiperazinium Iodide / Q000494:pharmacology*; D004347:Drug Interactions; D066298:In Vitro Techniques; D008297:Male; D009119:Muscle Contraction / Q000187:drug effects; D009130:Muscle, Smooth / Q000187:drug effects; D009474:Neurons / Q000187:drug effects / Q000378:metabolism*; D009638:Norepinephrine / Q000378:metabolism* / Q000494:pharmacology; D010879:Piperazines / Q000494:pharmacology*; D051381:Rats; D013564:Sympathetic Nervous System / Q000187:drug effects / Q000378:metabolism*; D014439:Tyramine / Q000378:metabolism* / Q000494:pharmacology; D014649:Vas Deferens / Q000187:drug effects
D010879:Piperazines; D004246:Dimethylphenylpiperazinium Iodide; D009638:Norepinephrine; D014439:Tyramine