Toxicity of poly(rI).poly(rC) for interferon-treated cells. An ultrastructural evaluation.
The cytotoxic effect of poly(rI).poly(rC) for interferon-treated cells is preceded by discrete ultrastructural alterations in (1) the mitochondria: swelling of the cristae and increased density of their matrix, (2) the nucleus: disorganization of the structure, and (3) the endoplasmic reticulum: slight dilatation with disorganization and depletion of the filament bundles. Our results do not allow us to conclude whether any of these alterations is a primary effect of the treatment. Possibly they are secondary to some, as yet unknown, functional defect, and only reflect incipient cell death.
D000818:Animals; D002467:Cell Nucleus / Q000648:ultrastructure; D004721:Endoplasmic Reticulum / Q000648:ultrastructure; D007372:Interferons / Q000494:pharmacology*; D007739:L Cells / Q000187:drug effects / Q000648:ultrastructure*; D051379:Mice; D008928:Mitochondria / Q000648:ultrastructure; D008933:Mitochondrial Swelling; D011070:Poly I-C / Q000633:toxicity*; D014617:Vacuoles / Q000648:ultrastructure
D007372:Interferons; D011070:Poly I-C