title: [Toxicity and antitumor activity of the antibiotic rubomycin and dipin in combination with diuretics (diacarb)].
abstract: Rubomycin or dipin in combination with diacarb had higher toxicity and antitumor activity as compared to administration of the cytostatic agents alone to mice with transplanted lymphosarcoma, strain L10-1. The chemotherapeutic indices of the combinations did not differ or were somewhat lower as compared to the same indices of the cytostatic agents used alone.
mesh_terms: D000086:Acetazolamide / Q000627:therapeutic use / Q000633:toxicity*; D000818:Animals; D000903:Antibiotics, Antineoplastic / Q000627:therapeutic use; D001388:Aziridines; D003498:Cyclic P-Oxides / Q000627:therapeutic use / Q000633:toxicity*; D003630:Daunorubicin / Q000627:therapeutic use / Q000633:toxicity*; D004353:Drug Evaluation, Preclinical; D004359:Drug Therapy, Combination; D005260:Female; D007928:Lethal Dose 50; D008228:Lymphoma, Non-Hodgkin / Q000188:drug therapy; D051379:Mice; D009368:Neoplasm Transplantation; D009374:Neoplasms, Experimental / Q000188:drug therapy; D010879:Piperazines / Q000627:therapeutic use / Q000633:toxicity*
chemical_list: D000903:Antibiotics, Antineoplastic; D001388:Aziridines; D003498:Cyclic P-Oxides; D010879:Piperazines; C007526:dipin; D000086:Acetazolamide; D003630:Daunorubicin
vernacular_title: Toksichnost' i protivoopukholevaia aktivnost' antibiotika rubomitsina i dipina pri sochetanii ikh s diuretikami (diakarbom)