[Imidazole nucleosides, III. Nucleosides of 4(5)-aminoimidazole-5(4)-carboxamide (author's transl)].
The synthesis and properties of 13 nucleosides derived from 5-aminoimidazole-4-carboxamide and from 4-aminoimidazole-5-carboxamide are described. The isomers were oriented by comparison of their spectra and colour reactions. All compounds were tested for anticancer activity. 4-Amino-1-(alpha-D-arabinopyranosyl)-imidazole-5-carboxamide significantly inhibits the growth of Ehrlich ascites carcinoma (fluid form) in mice.
D000620:Aminoimidazole Carboxamide / Q000031:analogs & derivatives / Q000627:therapeutic use; D000818:Animals; D002286:Carcinoma, Ehrlich Tumor / Q000188:drug therapy; D007093:Imidazoles / Q000031:analogs & derivatives / Q000138:chemical synthesis / Q000627:therapeutic use; D051379:Mice; D009705:Nucleosides / Q000138:chemical synthesis / Q000627:therapeutic use; D013329:Structure-Activity Relationship
D007093:Imidazoles; D009705:Nucleosides; D000620:Aminoimidazole Carboxamide
Imidazolnucleoside, III. Nucleoside des 4(5)-Aminoimidazol-5(4)-carboxamids.