The influence of hypercalcemia on basal and cholecystokinin-stimulated pancreatic, gallbladder, and gastric functions in man.
Hypercalcemia produced in normal volunteers by intravenous infusions of CaCl2 increased outputs of pancreatic enzyme and gastric acid. Further, hypercalcemia enhanced cholecystokinin (CCK)-stimulated pancreatic enzyme secretion and gallbladder contraction. Our results suggest that hypercalcemia affects pancreatic, gallbladder, and gastric functions as well as their responses to exogenous CCK.
D000328:Adult; D001663:Bilirubin / Q000378:metabolism; D002766:Cholecystokinin / Q000494:pharmacology*; D005704:Gallbladder / Q000187:drug effects / Q000503:physiopathology*; D005750:Gastric Juice / Q000378:metabolism; D005753:Gastric Mucosa / Q000187:drug effects; D005755:Gastrins / Q000097:blood; D006801:Humans; D006934:Hypercalcemia / Q000503:physiopathology*; D008297:Male; D010179:Pancreas / Q000187:drug effects / Q000378:metabolism / Q000503:physiopathology*; D010189:Pancreatic Juice / Q000378:metabolism; D013270:Stomach / Q000503:physiopathology*
D005755:Gastrins; D002766:Cholecystokinin; D001663:Bilirubin