Fibrin clots in the choriocapillaris and serous detachment of the retina.
Clot formation occurs preferentially in the choriocapillaris. With intraocular inflammation this clotting begins along the inner surface of the choriocapillaris suggesting that dilatation of the vessels and opening of the endothelial fenestra have initiated the process. With the systemic coagulopathy of thrombotic thrombocytopenia (TTP) and disseminated intravascular coagulopathy (DIC) clotting occurs preferentially in the submacular choriocapillaris, sometimes associated with choroidal hemorrhage and detachment of the retina. These complications are illustrated in the present paper by a patient with TTP showing relatively chronic coagulopathy and by three patients with DIC showing variations of acute coagulopathy.
D000328:Adult; D002829:Choroid / Q000098:blood supply*; D004211:Disseminated Intravascular Coagulation / Q000150:complications*; D005260:Female; D005337:Fibrin; D006801:Humans; D008297:Male; D008875:Middle Aged; D011247:Pregnancy; D011697:Purpura, Thrombotic Thrombocytopenic / Q000150:complications*; D012163:Retinal Detachment / Q000209:etiology*
D005337:Fibrin