title: [Pharmacokinetics of a combination of magnesium-chlorophenoxy-isobutyrate and meso-inositol hexanicotinate].
abstract: The absorption, blood level and renal excretion of chlorphenoxyisobutyric acid (clofibric acid) were examined following oral dosage of the magnesium salt (magnesium clofibrate) in a combination preparation containing meso-inositol hexanicotinate. Absorption of clofibric acid was found to be identical with that obtained with ethyl-alpha-p-chlorphenoxyisobutyrate (Clofibrate) reaching almost 100%. After dosage with the combination preparation, the maximum blood level of clofibric acid was achieved after 2 hours, in contrast to 4 hours for Clofibrate. No accumulation of clofibric acid in the blood was found after 60 days treatment with combination preparation at a daily dosage of 3 tablets. Urinary excretion of clofibric acid for both the combination drug and Clofibrate was 90% in 48 hours.
mesh_terms: D000328:Adult; D000368:Aged; D001702:Biopharmaceutics; D002994:Clofibrate / Q000008:administration & dosage / Q000378:metabolism* / Q000494:pharmacology; D004338:Drug Combinations; D006801:Humans; D007294:Inositol / Q000008:administration & dosage / Q000494:pharmacology*; D008297:Male; D008875:Middle Aged; D009539:Nicotinic Acids / Q000008:administration & dosage / Q000097:blood / Q000494:pharmacology*
chemical_list: D004338:Drug Combinations; D009539:Nicotinic Acids; D007294:Inositol; D002994:Clofibrate
vernacular_title: Pharmakokinetik einer Kombination von Magnesium-Chlorphenoxy-Isobutyrat und dem Hexanikotinsäureester des meso-Inosits.