Influence of uridine-5-monophosphate on 3H-leucine incorporation into hippocampal neurons during learning.
The influence of UMP (injected intraventricularly) on the incorporation of 3H-leucine (injected intraperitoneally) was studied in rats using the microautoradiographic technique. Under the conditions of a brightness discrimination, the incorporation of labeled leucine into hippocampal neurons was significantly increased by UMP pretreatment, whereas under control conditions UMP caused only a tendency of increase without any statistical significance. It is suggested, that under learning conditions UMP substitution increases RNA synthesis, which would yield an enhanced protein synthesis.
D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects; D004193:Discrimination Learning / Q000187:drug effects; D004597:Electroshock; D006624:Hippocampus / Q000378:metabolism*; D007276:Injections, Intraventricular; D007858:Learning / Q000502:physiology*; D007930:Leucine / Q000378:metabolism*; D008297:Male; D009474:Neurons / Q000378:metabolism*; D051381:Rats; D014500:Uracil Nucleotides / Q000008:administration & dosage / Q000494:pharmacology*
D014500:Uracil Nucleotides; D007930:Leucine