Release of protein and cations from the lens in the presence of different antigen-antibody interactions.
Rabbit lenses exposed to unrelated Ag/Ab interactions and to heterologous anti-lens and anti-uveo-retinal antibodies show alterations of their permeability with loss of Rb+ followed by efflux of macromolecular intracellular constituents; these phenomena take place also without complement when the ratio of the unrelated Ag/ab is in Ag excess, while complement is strictly required for the action of anti-tissue antibodies. The possible role of these findings as regards the pathogenesis of complicated cataracts in uveitis and the self-maintenance of recurrent uveitis is briefly discussed.
D000818:Animals; D000906:Antibodies; D000910:Antibodies, Heterophile; D000937:Antigen-Antibody Reactions; D002413:Cations, Divalent; D002417:Cattle; D003459:Crystallins / Q000276:immunology / Q000378:metabolism*; D006168:Guinea Pigs; D010539:Permeability; D011817:Rabbits; D012160:Retina / Q000276:immunology; D014602:Uvea / Q000276:immunology; D014605:Uveitis / Q000276:immunology
D000906:Antibodies; D000910:Antibodies, Heterophile; D002413:Cations, Divalent; D003459:Crystallins