Effect of perfusion of bile salts solutions into the oesophagus of hiatal hernia patients and controls.
Tests of the response to perfusion of the oesophagus were made in 54 patients divided into three groups. Group I consisted of patients with symptomatic hiatal hernia, group II hiatal hernia patients with peptic stricture, and group III normal individuals. Each individual oesophagus was perfused at a rate of 45-65 drops per minute over 25 minutes with six solutions: normal saline, N/10 HCl, taurine conjugates of bile salts in normal saline, taurine conjugates of bile salts in N/10 HCl, glycine conjugates of bile salts in normal saline, and taurine and glycine conjugates in a ratio of 1 to 2 in normal saline. It was found that acidified taurine solutions were more irritating than acid alone. With a 2mM/l solution of taurine in acid, symptoms are produced even in controls. With a 1 mM/l solution of the same conjugates, the majority of normal people feel slight heartburn or nothing, and therefore perfusion into the oesophagus of such a solution could be used as a test for oesophagitis.
D001647:Bile Acids and Salts / Q000494:pharmacology*; D004941:Esophagitis / Q000175:diagnosis; D004947:Esophagus / Q000187:drug effects*; D006356:Heartburn / Q000139:chemically induced; D006548:Hernia, Diaphragmatic / Q000503:physiopathology*; D006551:Hernia, Hiatal / Q000503:physiopathology*; D006801:Humans; D006851:Hydrochloric Acid / Q000494:pharmacology; D009325:Nausea / Q000139:chemically induced; D013654:Taurine / Q000494:pharmacology; D013997:Time Factors; D014839:Vomiting / Q000139:chemically induced
D001647:Bile Acids and Salts; D013654:Taurine; D006851:Hydrochloric Acid