Interaction of somatostatin and pentagastrin on lower oesophageal sphincter pressure (LESP) in man.
The effect of intravenous somatostatin on basal and gastrin-stimulated human lower esophageal sphincter pressure (LESP) was examined with the rapid pull-through technique. In a group of 7 healthy volunteers LESP was not influenced under basal conditions, but there was an augmented response to pulse-doses of pentagastrin (0.6 mug/kg) during infusion of somatostatin (250 mug/kg-h). The physiological importance of these findings still has to be evaluated.
D004357:Drug Synergism; D004943:Esophagogastric Junction / Q000187:drug effects*; D005260:Female; D006801:Humans; D008297:Male; D010418:Pentagastrin / Q000494:pharmacology*; D011312:Pressure; D013004:Somatostatin / Q000494:pharmacology*
D013004:Somatostatin; D010418:Pentagastrin