title: The intravascular magnetic suspension of a test device for in vivo hemocompatibility evaluation of biomaterials.
abstract: To advance hemocompatibility evaluation techniques, a new in vivo method has been developed for the dynamic testing of candidate biomaterials in suitably-sized experimental animals. One of the salient features this method is that the material to be evaluated constitutes the blood contact surface of a slender body of revolution which is coaxially suspended in a large canine vessel by electromagnetic forces only. The insertion site of the specimen is distal and downstream to the test region, reducing the influence of thrombotic tissue substances. These experimental conditions also insure that the only chronically exposed foreign surface is that of the test material, whose interactions with blood components are not affected by contact with the vessel intima. As demonstrated in simulated Circulation Model experiments, macroscopic thromboembolic phenomena induced by the test material can be continuously monitored. Preliminary in vivo trials have verified the validity of the underlying principles; the feasibility of the required surgical techniques, and the adequate performance of the suspension system.
mesh_terms: D000818:Animals; D001013:Aorta, Thoracic; D001672:Biocompatible Materials; D001769:Blood; D004285:Dogs; D055590:Electromagnetic Phenomena; D008722:Methods
chemical_list: D001672:Biocompatible Materials