Ouabain-induced release of extraneuronal catecholamine in the isolated guinea-pig vas deferens.
It was found that ouabain (10(-5) M) was effective in releasing the extraneuronal catecholamine which was taken up by uptake 2 process in the guinea-pig vas deferens. This result shows that a Na-K ATPase is essential for the storage of catecholamine in the extraneuronal site.
D000818:Animals; D001949:Bretylium Compounds / Q000494:pharmacology; D002395:Catecholamines / Q000502:physiology*; D003900:Desoxycorticosterone / Q000494:pharmacology; D004837:Epinephrine / Q000494:pharmacology; D006168:Guinea Pigs; D066298:In Vitro Techniques; D008297:Male; D008676:Metanephrine / Q000494:pharmacology; D009119:Muscle Contraction / Q000187:drug effects*; D009130:Muscle, Smooth / Q000187:drug effects / Q000502:physiology*; D009638:Norepinephrine / Q000494:pharmacology; D010042:Ouabain / Q000494:pharmacology*; D010118:Oxytetracycline; D010646:Phentolamine / Q000494:pharmacology; D012110:Reserpine / Q000494:pharmacology; D014649:Vas Deferens
D001949:Bretylium Compounds; D002395:Catecholamines; D003900:Desoxycorticosterone; D008676:Metanephrine; D010042:Ouabain; D012110:Reserpine; D010118:Oxytetracycline; D009638:Norepinephrine; D004837:Epinephrine; D010646:Phentolamine