title: [Clinical experiences with the serum digitalis concentration. 1006 radioimmunological determinations].
abstract: Serum digitalis concentration was measured radioimmunologically on 1006 patients in the period from 1974-1976. The serum levels were correlated with the clinical signs of digitalis toxicity and the indications for determination of the serum digoxin concentration were established. Clinical signs of toxicity appear at a serum level of digoxin above 2.5 ng/ml. Therapeutic limits (range) are most influenced by individual factors. Serum digoxin determination is especially necessary in patients with renal failure and in undisciplined patients with erratic digitalis intake. It is a useful aid in controlling the course of digitalis intoxication, in "low dosage" digitalization and in the case of possible drug interactions.
mesh_terms: D001145:Arrhythmias, Cardiac / Q000139:chemically induced; D004071:Digitalis Glycosides / Q000097:blood*; D004077:Digoxin / Q000097:blood / Q000633:toxicity; D005132:Eye Manifestations; D005767:Gastrointestinal Diseases / Q000139:chemically induced; D006333:Heart Failure / Q000175:diagnosis; D006801:Humans; D010349:Patient Compliance
chemical_list: D004071:Digitalis Glycosides; D004077:Digoxin
vernacular_title: Klinische Erfahrungen mit der Serum-Digitaliskonzentration. 1006 radioimmunologische Bestimmungen.