title: Allometric method for the long term observation of adjuvant arthritis in rats.
abstract: An allometric method for estimating the volume change in inflamed paw of rats is described. The technique is effective and advantageous for long term observation of adjuvant arthritis which lacks a suitable reference criterion due to the simultaneous swelling of the control paw. In the present method, the inflammatory intensity (IF) of paw edema is estimated by means of the formula; IF(%)=(2Vr/cXd(I+Wt/aXb)-I) X 100 where Vt is the paw volume, Wt is the body weight weight and X is the tail length of the inflamed rat. The constants a, b, c, and d are obtained from tthe normal rats using the relative growth law, W=aXb and V=cXd (where W is the body weight, V is the paw volume and X is the tail length).
mesh_terms: D000276:Adjuvants, Immunologic; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use; D001168:Arthritis / Q000188:drug therapy / Q000503:physiopathology*; D001699:Biometry; D001835:Body Weight; D008297:Male; D008433:Mathematics; D051381:Rats; D013997:Time Factors
chemical_list: D000276:Adjuvants, Immunologic; D000893:Anti-Inflammatory Agents