Antiarrhythmic effect of hypertonic sodium bicarbonate and sodium chloride in ouabain-induced arrhythmias.
Ouabain-induced tachyarrhythmias in cats can be abolished by bolus injection of NaHCO3 solution. This effect is consistent, rapid and of short duration. The antiarrhythmic effect appears to be due to high sodium concentration of this solution, as hypertonic NaCl solution with equal concentration of sodium exerts the same effect. Alkalinity and hyper-osmolality cannot account for the antiarrhythmic effect of NaHCO3 as respiratory alkalosis and mannitol solution with equal osmolality did not relieve the arrhythmias. Overdrive suppression is not responsible for this effect as the heart rate slows down during normalization of the cardiac rhythm. It is postulated that high Na+ concentration abolished ouabain-induced arrhythmias by competition with calcium ion in the myocardial cell sarcotubular system thus replacing it. This hypothesis is supported by the known effect of other agents such as sodium-EDTA and magnesium chloride, in digitalis-induced arrhythmias, which exert their antiarrhythmic properties by removal or displacement of calcium in the myocardial cells.
D000818:Animals; D001145:Arrhythmias, Cardiac / Q000139:chemically induced* / Q000188:drug therapy; D001639:Bicarbonates / Q000627:therapeutic use*; D002415:Cats; D004195:Disease Models, Animal; D004562:Electrocardiography; D008353:Mannitol / Q000627:therapeutic use; D009994:Osmolar Concentration; D010042:Ouabain / Q000008:administration & dosage; D010546:Perphenazine / Q000627:therapeutic use; D011398:Promethazine / Q000627:therapeutic use; D012462:Saline Solution, Hypertonic / Q000627:therapeutic use*; D012964:Sodium / Q000378:metabolism; D012965:Sodium Chloride / Q000627:therapeutic use*; D013610:Tachycardia / Q000139:chemically induced
D001639:Bicarbonates; D012462:Saline Solution, Hypertonic; D008353:Mannitol; D012965:Sodium Chloride; D010042:Ouabain; D012964:Sodium; D011398:Promethazine; D010546:Perphenazine