title: [Central action of a new cholinesterase reactivator, diethyxime].
abstract: In anesthetized cats, whose peripheral muscarinic-cholinorecptors are blocked by m-cholinolytics (benzilyl choline) failing to penetrate into the brain, the cholinesterases reactivator diethyxime debars the centrally caused fall of the arterial pressure produced by armine, an inhibitor of cholinesterases readily gaining access into the brain. Diethyxime is also capable of abolishing the depression of the phrenic nerve action potentials produced by armine. Dipyroxime-a quaternary diethyxime analogue and also a quaternary cholinesterase reactivator fails to produce such an effect.
mesh_terms: D000200:Action Potentials / Q000187:drug effects; D000818:Animals; D001812:Blood-Brain Barrier / Q000187:drug effects; D002415:Cats; D002496:Central Venous Pressure / Q000187:drug effects*; D002800:Cholinesterase Inhibitors / Q000494:pharmacology; D002801:Cholinesterase Reactivators / Q000494:pharmacology*; D009578:Nitrobenzenes / Q000494:pharmacology; D009943:Organophosphorus Compounds / Q000494:pharmacology; D010091:Oximes / Q000494:pharmacology*; D010791:Phrenic Nerve / Q000187:drug effects; D011950:Receptors, Cholinergic / Q000187:drug effects
chemical_list: D002800:Cholinesterase Inhibitors; D002801:Cholinesterase Reactivators; D009578:Nitrobenzenes; D009943:Organophosphorus Compounds; D010091:Oximes; D011950:Receptors, Cholinergic; C012284:diethyxime
vernacular_title: O tsentral'nom deĭstvii novogo reaktivatora kholinésteraz diétiksima.