Potential long-acting anticonvulsants. 2. Synthesis and activity of succinimides containing an alkylating group on nitrogen or at the 3 position.
The synthesis of succinimide derivatives in which alkylating groups have been attached to the imide nitrogen or to the 3 position of the ring is described. The synthesis of one bis-alkylating derivative 19 is also described. The alkylating groups used were (a) alpha-haloacetyl, (b) alpha-haloacetamido, (c) maleamyl, and (d) maleimido. These compounds were prepared as potential long-acting anticonvulsants. None of the compounds showed activity against maximal electroshock or metrazole-induced seizures.
D000477:Alkylating Agents / Q000138:chemical synthesis*; D000818:Animals; D002626:Chemistry, Pharmaceutical; D008297:Male; D051379:Mice; D012640:Seizures / Q000188:drug therapy; D013329:Structure-Activity Relationship; D013388:Succinimides / Q000138:chemical synthesis / Q000627:therapeutic use
D000477:Alkylating Agents; D013388:Succinimides