title: The influence of hepatic microsomal amidopyrine demethylase activity on halothane hepatotoxicity in the horse.
abstract: The hepatotoxic effect of oral halothane in the horse is increased by pretreatment with phenobarbitone or DDT but not by chlorpromazine. Phenobarbitone and DDT increase the activity of hepatic amidopyrine N-demethylase but chlorpromazine does not. Carbon disulphide protects the liver of the horse against halothane.
mesh_terms: D000633:Aminopyrine N-Demethylase / Q000037:antagonists & inhibitors / Q000378:metabolism*; D000818:Animals; D002246:Carbon Disulfide / Q000494:pharmacology; D056486:Chemical and Drug Induced Liver Injury; D002746:Chlorpromazine / Q000494:pharmacology; D003634:DDT / Q000494:pharmacology; D006221:Halothane / Q000633:toxicity*; D006736:Horses / Q000378:metabolism*; D008099:Liver / Q000187:drug effects* / Q000201:enzymology; D008862:Microsomes, Liver / Q000201:enzymology*; D009336:Necrosis; D010634:Phenobarbital / Q000494:pharmacology
chemical_list: D003634:DDT; D000633:Aminopyrine N-Demethylase; C019666:amidopyrine N-demethylase; D002246:Carbon Disulfide; D002746:Chlorpromazine; D006221:Halothane; D010634:Phenobarbital