title: [Binding of cortisol, fluocortolone and difluocortolone to human plasma proteins (author's transl)].
abstract: The binding properties of [3H]cortisol, [3H]fluocortolone and [3H]difluocortolone by human plasma, human albumin, human- beta- and gamma-globulins have been studied by equilibrium dialysis. Cortisol, in physiological concentrations (0,4 micromol/l), is 98% bound in human plasma at 25 degrees C, fluocortolone 96% and diflucortolone 85%. Uncer physiological conditions cortisol is mainly bound to the corticosteroid binding globulin (transcortin). 2/3 of fluocortolone is bound to transcortin and 1/3 to albumin and globulins, whereas difluocortolone is mainly bound to albumin and to globulins but not to transcortin. The binding affinities of beta- and gamma-globulins are -ery low for the corticoids investigated, but they are higher for fluocortolone and difluocortolone than for cortisol.
mesh_terms: D002352:Carrier Proteins / Q000097:blood*; D005448:Fluocortolone / Q000031:analogs & derivatives / Q000097:blood*; D006801:Humans; D006854:Hydrocortisone / Q000097:blood*; D007700:Kinetics; D011244:Pregnadienediols / Q000097:blood*; D012709:Serum Albumin / Q000378:metabolism; D012712:Serum Globulins / Q000378:metabolism; D013329:Structure-Activity Relationship
chemical_list: D002352:Carrier Proteins; D011244:Pregnadienediols; D012709:Serum Albumin; D012712:Serum Globulins; D005448:Fluocortolone; D006854:Hydrocortisone
vernacular_title: Bindung von cortisol, Fluocortolon und Difluocortolon an Humanplasmaproteine.