Inactivation of the phosphoenolpyruvate-dependent phosphotransferase system in various species of bacteria by vinylglycolic acid.
The alkenoic hydroxyacid 2-hydroxy-3-butenoic acid (vinylglycolate) specifically inhibited the phosphotransferase system in a variety of bacteria while not affecting respiration-coupled transport systems.
D001419:Bacteria / Q000201:enzymology* / Q000378:metabolism; D002462:Cell Membrane / Q000201:enzymology / Q000378:metabolism; D003437:Crotonates / Q000378:metabolism; D003847:Deoxyglucose / Q000378:metabolism; D004794:Enzyme Repression; D005947:Glucose / Q000378:metabolism; D006880:Hydroxy Acids / Q000494:pharmacology*; D008757:Methylglucosides / Q000378:metabolism; D010728:Phosphoenolpyruvate / Q000378:metabolism; D010770:Phosphotransferases / Q000378:metabolism*; D013045:Species Specificity; D013395:Sucrose / Q000378:metabolism; D013862:Thiogalactosides / Q000378:metabolism
D003437:Crotonates; D006880:Hydroxy Acids; D008757:Methylglucosides; D013862:Thiogalactosides; D013395:Sucrose; C009670:vinylglycolic acid; D010728:Phosphoenolpyruvate; D003847:Deoxyglucose; D010770:Phosphotransferases; D005947:Glucose