Preparation and testing of vaccines prepared from the envelopes of Venezuelan, eastern, and western equine encephalomyelitis viruses.
Envelope components were separated from Venezuelan, Eastern, and Western equine encephalomyelitis viruses after treatment of the virions with detergent. Vaccines prepared from the envelope component were capable of stimulating mice to produce humoral antibodies. Protective efficacy studies were performed using mono-, di-, and trivalent vaccine combinations. These elicited varying degrees of homologous protection, and Eastern and Venezuelan equine encephalomyelitis envelope products appeared to confer protection to mice challenged with Western equine encephalomyelitis virus.
D000818:Animals; D000914:Antibodies, Viral / Q000032:analysis; D000917:Antibody Formation; D004663:Encephalitis Virus, Eastern Equine / Q000187:drug effects / Q000276:immunology*; D004666:Encephalitis Virus, Venezuelan Equine / Q000187:drug effects / Q000276:immunology*; D004668:Encephalitis Viruses / Q000276:immunology*; D004671:Encephalitis, Arbovirus / Q000517:prevention & control; D007114:Immunization; D051379:Mice; D011092:Polyethylene Glycols / Q000494:pharmacology; D014613:Vaccines, Attenuated; D014765:Viral Vaccines
D000914:Antibodies, Viral; D014613:Vaccines, Attenuated; D014765:Viral Vaccines; D011092:Polyethylene Glycols