title: Friedreich's disease--a family study.
abstract: Friedreich's disease occurring in 4 male siblings in a sibship of seven caused cardiac and neurological abnormalities and one twin of an affected member died in cardiac failure; at autopsy characteristic pathological features of Friedreich's disease were demonstrated in the nervous system and heart. One female sibling had a patent ductus arteriosus which was treated surgically and a continuous murmur was present in another sister but cardiac catheterization in childhood had been normal.
mesh_terms: D000328:Adult; D005260:Female; D006331:Heart Diseases / Q000150:complications / Q000235:genetics* / Q000473:pathology; D006801:Humans; D008297:Male; D009206:Myocardium / Q000473:pathology; D009207:Myoclonus / Q000150:complications / Q000235:genetics* / Q000473:pathology