title: [Concentration dependent effect of 5-ethyl-2'-deoxyuridine on experimental and clinical herpetic keratitis (author's transl)].
abstract: Concentration dependent effect of 5-ethyl-2'-deoxyuridine (EDU) on epithelial regeneration and on herpes keratitis in rabbit has been studied. Successfull completion of the experimental studies was followed by clinical treatment of 10 otherwise therapy resistent metaherpetic cases using 2% EDU eye drops and 0,5% subconjunctival injections. With nine patients under this therapy improvement and healing of the corneal processes was achieved.
mesh_terms: D000328:Adult; D000368:Aged; D000818:Animals; D003857:Deoxyuridine / Q000008:administration & dosage* / Q000494:pharmacology / Q000627:therapeutic use; D004341:Drug Evaluation; D005260:Female; D006801:Humans; D007635:Keratitis, Dendritic / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged; D009883:Ophthalmic Solutions; D011817:Rabbits; D012038:Regeneration / Q000187:drug effects
chemical_list: D009883:Ophthalmic Solutions; D003857:Deoxyuridine
vernacular_title: Konzentrationsabhängige Wirksamkeit von 5 Athyl-2-desoxyuridin (ADU) bei herpetischen Keratitiden im Tierexperiment und in der Klinik.