Reduction by propranolol of raised urinary output of MHPG in hyperactive rats.
Prolonged isolation of rats resulted in hyperactivity in the open field and a significant increase in 24 hr urinary excretion of MHPG (3-methoxy-4-hydroxyphenylglycol). Exploratory activity of group-housed rats in open field was not associated with raised MHPG excretion, compared with that of rats remaining in home cages. Exposure of group-housed rats to 4 degrees C for 2 hr also increased urinary excretion of MHPG. Pretreatment of isolated rats with dl-, d-propranolol or practolol abolished hyperactivity of isolated rats and reduced MHPG output in these rats and in rats exposed to cold. dl-Propranolol did not reduce activity of group-housed rats in open field or their urinary excretion of MHPG. It is suggested that propranolol may have a selective inhibitory effect on stress-induced increases in noradrenaline turnover.
D000818:Animals; D003080:Cold Temperature; D005106:Exploratory Behavior / Q000187:drug effects*; D006018:Glycols / Q000652:urine*; D008297:Male; D008734:Methoxyhydroxyphenylglycol / Q000652:urine*; D009043:Motor Activity / Q000187:drug effects*; D011433:Propranolol / Q000494:pharmacology*; D051381:Rats; D012934:Social Isolation
D006018:Glycols; D008734:Methoxyhydroxyphenylglycol; D011433:Propranolol