Lysis of donor RBC during plateletpheresis with a blood processor.
Erythrocytes of a normal volunteer blood donor were grossly hemolyzed during plateletpheresis with the use of a continuous-flow centrifuge. Extensive studies of the donor's red blood cells (RBC) showed no abnormalities. Bank blood was then processed in the centrifuge in a manner identical to the prescribed in vivo plateletpheresis. Gross hemolysis consistently resulted when the tubing on the downstream side of the blood pump was partially obstructed by a twist. This experience calls for caution when assembling the harness of an extracorporeal circuit employing a pump. The tubing should be inspected to ensure the absence of obstructions.
D000328:Adult; D001782:Blood Donors; D001792:Blood Platelets; D006461:Hemolysis; D006801:Humans; D008297:Male; D010956:Plasmapheresis / Q000009:adverse effects*