title: [Electron microscopic study of the kinetics of smallpox vaccine interaction with alveolar macrophages when administered intratracheally].
abstract: Electron microscopy was applied to the study of the dynamics of endocytosis of smallpox vaccine by alveolar macrophages in intratracheal immunization of guinea pigs; 5 to 15 minutes after administration of smallpox vaccine the viruses were absorbed on the macrophage surface, penetrated into the cells by invagination and vesiculation. A possibility of adaption of smallpox virus in the alveolar macrophages 12 hours after the vaccination was confirmed documentally.
mesh_terms: D000284:Administration, Oral; D000336:Aerosols; D000818:Animals; D006168:Guinea Pigs; D007114:Immunization; D007700:Kinetics; D008264:Macrophages / Q000187:drug effects*; D008854:Microscopy, Electron; D011650:Pulmonary Alveoli / Q000648:ultrastructure*; D011817:Rabbits; D012900:Smallpox Vaccine / Q000494:pharmacology*; D013997:Time Factors
chemical_list: D000336:Aerosols; D012900:Smallpox Vaccine
vernacular_title: Elektronnomikroskopicheskoe izuchenie kinetiki vzaimodeĭstviia ospovaktsiny s al'veoliarnymi makrofagami pri intratrakheal'nom vvedenii