title: Anthelmintic 1-cinnamamido-2,4-imidazolidinediones.
abstract: A series of 1-(substituted cinnamamido)-2,4-imidazolidinediones has been prepared from the corresponding cinnamoyl chlorides and 1-amino-2,4-imidazolidinedione hydrochloride in pyridine. These compounds possess a significant degree of anthelmintic activity against the mouse pinworm Syphacia obvelata. The most active compounds are those substituted with halogen or cyano groups.
mesh_terms: D000818:Animals; D000871:Anthelmintics / Q000138:chemical synthesis*; D000969:Antinematodal Agents / Q000138:chemical synthesis / Q000627:therapeutic use; D002934:Cinnamates / Q000138:chemical synthesis / Q000627:therapeutic use; D007093:Imidazoles / Q000138:chemical synthesis* / Q000627:therapeutic use; D051379:Mice; D010123:Oxyuriasis / Q000188:drug therapy; D010124:Oxyuroidea
chemical_list: D000871:Anthelmintics; D000969:Antinematodal Agents; D002934:Cinnamates; D007093:Imidazoles