Effects of angiotensin and prostaglandin A2 in perfused isolated kidneys of dogs.
Simultaneous recordings of pressure and flow were made from the renal artery in perfused isolate canine kidneys. The system was perturbated by the administration of angiotensin and prostaglandin A2. The data were recorded on frequency-modulated analog tape and converted to digital form, and a Fast Fourier Transform program was used to calculate input impedance. Changes in total renal volume and renal arterial pressure data were used to determine compliance values. in compliance were found, along with changes in both magnitude of impedance and phase angle, as a result of the perturbations introduced. Seemingly, renal vascular compliance has an important role in the autoregulatory mechanisms of the kidney.
D000804:Angiotensin II / Q000494:pharmacology*; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D004285:Dogs / Q000502:physiology*; D006400:Hematocrit; D066298:In Vitro Techniques; D007668:Kidney / Q000187:drug effects*; D010477:Perfusion; D011454:Prostaglandins A / Q000494:pharmacology*; D012039:Regional Blood Flow / Q000187:drug effects; D012077:Renal Artery / Q000187:drug effects / Q000502:physiology; D012082:Renal Veins / Q000187:drug effects / Q000502:physiology; D014556:Urine / Q000502:physiology; D014655:Vascular Resistance / Q000187:drug effects; D014690:Venous Pressure / Q000187:drug effects
D011454:Prostaglandins A; D000804:Angiotensin II