New compounds: organoboron derivatives of tetracyclines I: synthesis of carboxamido derivative of tetracycline with perhydro-2-phenyl-1,3,6,2-dioxazaborocine.
An organoboron carboxamido derivative of tetracycline, designed for use in the 105B-thermal neutron-capture treatment of cancer, was synthesized under the conditions of the Mannich reaction using perhydro-2-phenyl-1,3,6,2-dioxazaborocine as the amine component. Spectral data (UV, IR, and NMR) for the compound and its hydrolytic stability are discussed.
D001896:Boron Compounds / Q000138:chemical synthesis*; D009682:Magnetic Resonance Spectroscopy; D012270:Ribosomes / Q000378:metabolism; D013055:Spectrophotometry, Infrared; D013056:Spectrophotometry, Ultraviolet; D013754:Tetracyclines / Q000032:analysis / Q000138:chemical synthesis*
D001896:Boron Compounds; D013754:Tetracyclines