title: Levels of immunoglobulin E (IgE) in paired examinations of serum and synovial fluid in rheumatoid arthritis and reactive synovitis of local origin.
abstract: Levels of IgE were examined in pairs of serum and synovial fluid of the knee joint in a series of 78 patients with rheumatoid arthritis (RA), reactive synovitis during osteoarthrosis, and after injury. The IgE levels in synovial fluid were significantly lower (p less than 0.05) in all groups; in RA, they were in significant correlation (r=0.6208, p less than 0.0001) and in direct linear regression to the levels in serum. In 5 patients of the whole series, however, the IgE levels in serum were lower by one order of magnitude as compared with synovial fluid. Serum levels of IgE in RA were in significant correlation and in direct linear regression to the titres of rheumatoid factors according to the latex-fixation test (r=0.3688, p=0.0249) and the haemagglutination test with sheep red cells (r=0.3721, p=0.0235).
mesh_terms: D000328:Adult; D000368:Aged; D001172:Arthritis, Rheumatoid / Q000097:blood / Q000378:metabolism*; D001847:Bone Diseases / Q000150:complications; D005260:Female; D006801:Humans; D007073:Immunoglobulin E / Q000032:analysis*; D007592:Joint Diseases / Q000150:complications; D007718:Knee Injuries / Q000150:complications; D008297:Male; D008875:Middle Aged; D013582:Synovial Fluid / Q000032:analysis*; D013585:Synovitis / Q000097:blood / Q000209:etiology / Q000378:metabolism*
chemical_list: D007073:Immunoglobulin E