Influence of WA-335, a factor which blocks serotonin receptors, on neuroleptic-induced catalepsy.
In a previous study, anticataleptic action of cyproheptadine was reported. The present investigation deals with the influence of WA-335 (9,10-dihydro-10-(1-methyl-4-piperidylidene)-9-anthrol), another antagonist of serotonin, on catalepsy induced in rats with spiroperidol, pimozide, fluphenazine and reserpine. WA-335 antagonized catalepsy induced by these neuroleptics (the effect on reserpine-induced catalepsy was weakest). Joint administration of WA-335 and L-DOPA with an inhibitor of peripheral decarboxylase, or WA-335 and amantadine produced a stronger antagonistic effect (spiroperidol catalepsy) than either of these substances separately. WA-335 did not prevent catalepsy induced with physostigmine.
D000547:Amantadine / Q000494:pharmacology; D000818:Animals; D000873:Anthracenes / Q000494:pharmacology* / Q000627:therapeutic use; D002375:Catalepsy / Q000139:chemically induced / Q000188:drug therapy*; D004357:Drug Synergism; D005260:Female; D006801:Humans; D007980:Levodopa / Q000494:pharmacology; D008297:Male; D010830:Physostigmine / Q000494:pharmacology; D010880:Piperidines / Q000494:pharmacology* / Q000627:therapeutic use; D051381:Rats; D011955:Receptors, Drug / Q000187:drug effects*; D012110:Reserpine / Q000009:adverse effects / Q000037:antagonists & inhibitors; D012701:Serotonin / Q000378:metabolism*; D014149:Tranquilizing Agents / Q000009:adverse effects / Q000037:antagonists & inhibitors*
D000873:Anthracenes; D010880:Piperidines; D011955:Receptors, Drug; D014149:Tranquilizing Agents; D012701:Serotonin; D007980:Levodopa; D012110:Reserpine; D010830:Physostigmine; D000547:Amantadine