Effect of clonidine on the noradrenergic cyclic AMP generating system in the limbic forebrain and on medial forebrain bundle self-stimulation behavior.
The present results show that clonidine does not mimic the agonist action of norepinephrine (NE) on the noradrenergic cyclic AMP generating system of the limbic forebrain, but antagonizes the stimulatory effect of NE while not influencing the action of isoprenaline. In self-stimulation behavior, clonidine decreases responding and blocks the facilitation caused by d-amphetamine.
D000249:Adenosine Monophosphate / Q000096:biosynthesis*; D000818:Animals; D003000:Clonidine / Q000494:pharmacology*; D003913:Dextroamphetamine / Q000037:antagonists & inhibitors; D008032:Limbic System / Q000187:drug effects*; D008297:Male; D009638:Norepinephrine / Q000037:antagonists & inhibitors; D051381:Rats; D012653:Self Stimulation / Q000187:drug effects*
D000249:Adenosine Monophosphate; D003000:Clonidine; D003913:Dextroamphetamine; D009638:Norepinephrine