Pharmacology of 9-gamma-methylaminopropyl-9,10-dihydro-9,10-methanoanthracene-HCl (ID-9206-HCl), a new potent antidepressant.
The pharmacological properties of 9-gamma-methylaminopropyl-9,10-dihydro-9,10-methanoanthracene-HCl (ID-9206-HCl) were examined in comparison with those of imipramine, amitriptyline and maprotiline in animals. ID-9206 showed the characteristic pharmacological profile of an antidepressent: anti-reserpine and anti-tetrabenazine activities, potentiation of central and peripheral actions of norepinephrine, and potentiation of methamphetamine and yohimbine actions. ID-9206 had weak peripheral anticholinergic activities and sedative effects. ID-9206 was less toxic in mice and rats than the other three antidepressants.
D000109:Acetylcholine / Q000037:antagonists & inhibitors; D000818:Animals; D000873:Anthracenes / Q000494:pharmacology*; D000929:Antidepressive Agents, Tricyclic / Q000494:pharmacology*; D001763:Blepharoptosis / Q000139:chemically induced / Q000503:physiopathology; D001831:Body Temperature / Q000187:drug effects; D004357:Drug Synergism; D006168:Guinea Pigs; D006591:Hexobarbital / Q000494:pharmacology; D008297:Male; D008694:Methamphetamine / Q000494:pharmacology; D051379:Mice; D009043:Motor Activity / Q000187:drug effects; D009119:Muscle Contraction / Q000187:drug effects; D009130:Muscle, Smooth / Q000187:drug effects; D009638:Norepinephrine / Q000494:pharmacology; D051381:Rats; D012110:Reserpine / Q000037:antagonists & inhibitors; D012890:Sleep / Q000187:drug effects; D013747:Tetrabenazine / Q000037:antagonists & inhibitors; D014203:Tremorine / Q000037:antagonists & inhibitors; D015016:Yohimbine / Q000633:toxicity
D000873:Anthracenes; D000929:Antidepressive Agents, Tricyclic; D015016:Yohimbine; D008694:Methamphetamine; C015615:9-methylaminopropyl-9,10-dihydro-9,10-methanoanthracene.HCl; D012110:Reserpine; D006591:Hexobarbital; D000109:Acetylcholine; D014203:Tremorine; D009638:Norepinephrine; D013747:Tetrabenazine