title: Effect of parenteral zinc on paraquat toxicity in the rat.
abstract: The purpose of this study was to determine if elevating lung zinc would prevent the lethal effect of paraquat. Several doses of zinc sulfate (20, 40, and 80 mg/kg) were administered intraperitoneally for 7 days and lung ainc measured. Only 80 mg/kg produced a significantly increase. Acute administration of 80 mg/kg zinc sulfate produced an 81% elevation in lung zinc within 4 hr. Animals were treated with zinc sulfate (80 mg/kg) followed 4 hr later by paraquat (42.5 mg/kg). They also received 2 additional doses of zinc during the next 48 hr. Zinc treated animals were not protected against the lethal effect of paraquat but, instead, had a higher fatality rate than animals treated with paraquat alone.
mesh_terms: D000818:Animals; D004357:Drug Synergism; D008168:Lung / Q000378:metabolism; D008171:Lung Diseases / Q000139:chemically induced / Q000517:prevention & control*; D010269:Paraquat / Q000037:antagonists & inhibitors* / Q000633:toxicity; D051381:Rats; D013997:Time Factors; D015032:Zinc / Q000378:metabolism / Q000494:pharmacology* / Q000633:toxicity
chemical_list: D015032:Zinc; D010269:Paraquat