Direct toxic effect of isoproterenol on cultured cardiac muscle cells.
Isoproterenol at relatively high doses (2.5 mg/ml) has a marked toxic effect on rat heart muscle cells cultivated in vitro. This effect is not prevented by propranolol and therefore is not mediated by beta adrenergic receptors.
D000818:Animals; D000831:Animals, Newborn; D002478:Cells, Cultured; D006321:Heart / Q000187:drug effects*; D007545:Isoproterenol / Q000633:toxicity*; D051381:Rats
D007545:Isoproterenol