Synthesis and properties of [11-serine]alpha-melanotropin.
[Ser11]alpha-melanotropin has been prepared and its melanotropic activity compared with that of alpha-melanotropin and several known analogues. Full activity does not depend on the positive charge of 11-lysine in alpha-melanotropin but on the hydrophilic character of the amino group or a corresponding residue. A shift, or even more, a loss of such a group decreases the melanotropic activity.
D000595:Amino Acid Sequence; D009074:Melanocyte-Stimulating Hormones / Q000031:analogs & derivatives* / Q000138:chemical synthesis; D008722:Methods; D012694:Serine; D013329:Structure-Activity Relationship
D012694:Serine; D009074:Melanocyte-Stimulating Hormones