[Effects of oxyfedrine on sino-atrial function and on conduction in patients with sinus node and/or atrial dysrhythmias (author's transl)].
The electrophysiological effects of Oxyfedrine on sino-atrial function and on A-V junctional and subjunctional conduction have been studied in 16 patients with sinus node and/or atrial dysrhythmias. The following effects have been observed: --a positive chronotropic effect on the sinus node; --an essentially indirect (rate-dependent) shortening of the Functional and Effective Refractory Periods (FRP and ERP) of the atria without variation of the Intra-Atrial Conduction Time (HRA-LRA). There was no significant shortening of the Maximal Atrial Latency (max AL), of the Corrected Sinus Node Recovery Time (CSNRT) and of the Sino-Atrial Conduction Time (SACT). The limits of Zones I, II, III of the sinus node response to atrial extra-stimuli were reduced with no significant change in their duration, expressed as percentage of the Sinus Cycle Length (SCL); --an improvement in the A-V junctional conduction (shortening of the A-H interval for comparable cycle lengths) due to a relatively shortened A-V junctional ERP. The use of the drug in patients with sinus bradycardia and/or atrial dysrhythmias and conduction disturbances, is proposed.
D000328:Adult; D000368:Aged; D001919:Bradycardia / Q000188:drug therapy; D004341:Drug Evaluation; D004562:Electrocardiography; D005260:Female; D006327:Heart Block / Q000188:drug therapy*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010099:Oxyfedrine / Q000627:therapeutic use*; D011427:Propiophenones / Q000627:therapeutic use*; D012848:Sinoatrial Block / Q000188:drug therapy* / Q000503:physiopathology; D012849:Sinoatrial Node / Q000187:drug effects*; D013997:Time Factors
D011427:Propiophenones; D010099:Oxyfedrine
Effetti dell'ossifedrina sulla funzione seno-atriale e sulla conduzione in pazienti con disritmie sinusali e/o atriali.