Hypomagnesemia in relation to digoxin intoxication in children.
Serum magnesium estimation was done in 19 children who had heart failure of varied etiology. Five of nine toxic patients and three of 10 nontoxic ones had magnesium deficiency (serum magnesium less than 1.5 mEq. per liter). Mean serum magnesium level was significantly lowered (P less than 0.01) in 19 children and it was further lowered in nine toxic patients (P less than 0.001) as well as in eight hypomagnesemic patients (P less than 0.001) than in healthy control subjects. Mean serum digoxin level in toxic patients was significantly higher than in nontoxic ones (P less than 0.05). In three cases magnesium sulfate was successfully used for the management of cardiac arrhythmias.
D000293:Adolescent; D001145:Arrhythmias, Cardiac / Q000139:chemically induced* / Q000188:drug therapy; D002648:Child; D002675:Child, Preschool; D004077:Digoxin / Q000097:blood / Q000506:poisoning* / Q000627:therapeutic use; D006330:Heart Defects, Congenital / Q000188:drug therapy; D006333:Heart Failure / Q000188:drug therapy*; D006801:Humans; D008274:Magnesium / Q000097:blood*; D008275:Magnesium Deficiency / Q000209:etiology; D008278:Magnesium Sulfate / Q000627:therapeutic use; D012214:Rheumatic Heart Disease / Q000188:drug therapy
D004077:Digoxin; D008278:Magnesium Sulfate; D008274:Magnesium