Role of catecholamines in release of gonadotrophic hormones in the rabbit.
Role of catecholamines (CA) in transmission of neurohormone releasing gonadotrophin (GnHR) from the hypothalamus to hypophysis was estimated on the basis of the hypothalamic catecholaminergic system blockade with 6-hydroxydopamine (6-OHDA) and intraventricular infusions of CA in the rabbit. 6-OHDA administered intraventricularly in doses 200-500 mug caused temporary blockade of ovulation. Intraventricular infusion of noradrenaline (NA) induced ovulation in 50% of animals tested, whereas dopamine (DA) and adrenaline (A), induced ovulation only in very few cases. It seems, that catecholaminergic system participates in transmission of neurohormones to the hypophysis, and NA plays the most important role in this process.
D000818:Animals; D002395:Catecholamines / Q000502:physiology*; D003864:Depression, Chemical; D004837:Epinephrine / Q000502:physiology; D005260:Female; D006062:Gonadotropins / Q000378:metabolism*; D006892:Hydroxydopamines / Q000008:administration & dosage / Q000494:pharmacology; D007030:Hypothalamo-Hypophyseal System / Q000502:physiology; D007278:Injections, Spinal; D009638:Norepinephrine / Q000502:physiology; D010060:Ovulation / Q000187:drug effects; D011817:Rabbits
D002395:Catecholamines; D006062:Gonadotropins; D006892:Hydroxydopamines; D009638:Norepinephrine; D004837:Epinephrine