[Effect of drug preparation combinations on intrauterine development].
On the 13th day of pregnancy chloridine (50 mg/kg) or 6-mercaptopurine (60 mg/kg) was administered to rats. Thirty minutes before this the anomals received insulin (40 IU/kg), pentoxyl (100 mg/kg), ethonium (15 mg/kg), dimexide (5500 mg/kg), or magnesium sulphate (250 mg/kg). Oi the 20th day of preganancy the animals were sacrificed. While chloridine and 6-mercaptopurine caused abnormal development in all live embryos, their damaging (teratogenic and embryolethal) and action was sharply reduced when teratogens were used in combination with other drugs. The author feels that the normalizing effect of the study agents is due to the influence of these compounds on the functioning of the lysosome-segregational system.
D000014:Abnormalities, Drug-Induced / Q000209:etiology*; D000818:Animals; D004338:Drug Combinations; D004347:Drug Interactions; D005260:Female; D005313:Fetal Death / Q000139:chemically induced; D005333:Fetus / Q000187:drug effects*; D005865:Gestational Age; D008247:Lysosomes / Q000187:drug effects; D015122:Mercaptopurine / Q000494:pharmacology*; D011247:Pregnancy; D011739:Pyrimethamine / Q000494:pharmacology*; D051381:Rats; D013723:Teratogens; D013997:Time Factors
D004338:Drug Combinations; D013723:Teratogens; D015122:Mercaptopurine; D011739:Pyrimethamine
Vliianie nekotorykh sochetaniĭ lekarstvennykh preparatov na vnutriutrobnoe razvitie.