Protective effects of cholestyramine in rats fed a low-fiber diet containing toxic doses of sodium cyclamate or amaranth.
Immature male rats were fed a purified, low-fiber diet containing massive doses of sodium cyclamate or amaranth (FD and C Red No. 2). Sodium cyclamate when incorporated at a 5% level in the purified, low-fiber diet resulted in toxic manifestations which were counteracted by the concurrent administration of the anion exchange resin cholestyramine at a 2 1/2% level in the diet. Other anion exchange resins were also active in this regard. Cholestyramine at a 2 1/2% level of supplementation was also active in counteracting the toxic effects induced by amaranth when the latter was incorporated at a 5% level in the purified, low-fiber diet.
D000548:Amaranth Dye / Q000633:toxicity*; D000818:Animals; D000837:Anion Exchange Resins / Q000627:therapeutic use; D001391:Azo Compounds / Q000633:toxicity*; D001835:Body Weight; D002792:Cholestyramine Resin / Q000627:therapeutic use*; D003494:Cyclamates / Q000633:toxicity*; D004032:Diet; D008297:Male; D011620:Psyllium / Q000627:therapeutic use; D051381:Rats
D000837:Anion Exchange Resins; D001391:Azo Compounds; D003494:Cyclamates; D002792:Cholestyramine Resin; D011620:Psyllium; D000548:Amaranth Dye