Lipid-lowering activity of phytostanols in rats.
In the present study, the hypocholesterolemic activity of phytosterols and phytostanols was compared. Phytostanols were prepared by hydrogenating a phytosterol mixture from corn oil and were fed at different levels (0.1-1.0%) to male rats for 10 to 14 days with or without cholesterol (1.0%). In an appropriate combination with cholesterol, phytostanols showed significantly greater activity in lowering the plasma and possibly liver cholesterol levels in comparison with the corresponding phytosterols. The stanols further stimulated the fecal recovery of cholesterol. The rate of intestinal absorption of phytostanols appeared obviously lower than that of phytosterols and thus the deposition into plasma and liver lipids was almost negligible.
D000818:Animals; D000924:Anticholesteremic Agents / Q000494:pharmacology*; D002784:Cholesterol / Q000097:blood; D002788:Cholesterol Esters / Q000097:blood; D002791:Cholesterol, Dietary / Q000009:adverse effects; D004305:Dose-Response Relationship, Drug; D005243:Feces / Q000032:analysis; D006529:Hepatomegaly / Q000517:prevention & control; D006937:Hypercholesterolemia / Q000517:prevention & control; D008658:Inactivation, Metabolic; D008099:Liver / Q000378:metabolism; D008297:Male; D008657:Metabolic Clearance Rate; D010840:Phytosterols / Q000378:metabolism / Q000494:pharmacology*; D051381:Rats; D014280:Triglycerides / Q000097:blood
D000924:Anticholesteremic Agents; D002788:Cholesterol Esters; D002791:Cholesterol, Dietary; D010840:Phytosterols; D014280:Triglycerides; D002784:Cholesterol