Effect of anti-inflammatory drugs on lipase in vitro.
Mefenamic acid, and to a lesser extent, flufenamic acid have a significant inhibitory effect on lipolysis as determined by the action of mouse pancreas lipase on the dilauric (didodecanoic) acid ester of fluorescein. Ibuprofen, fenoprofen calcium, phenylbutazone, oxyphenbutazone and alclofenac had comparatively little effect.
D000818:Animals; D000893:Anti-Inflammatory Agents / Q000009:adverse effects; D003967:Diarrhea / Q000139:chemically induced; D005439:Flufenamic Acid; D006801:Humans; D066298:In Vitro Techniques; D008049:Lipase / Q000037:antagonists & inhibitors*; D008528:Mefenamic Acid; D051379:Mice
D000893:Anti-Inflammatory Agents; D008528:Mefenamic Acid; D005439:Flufenamic Acid; D008049:Lipase