title: [Effects of hepato-biliary diseases on drug metabolism (author's transl)].
abstract: Drug metabolism may be impaired in patients with hepato-biliary diseases. Hepatocellular failure may decrease the rate of drug biotransformation; cholestasis may decrease 1) the absorption of lipid soluble drugs, 2) the rate of drug biotransformation, and 3) the biliary excretion of drugs. Activity and/or toxicity are modified variously as either the drug or a metabolite of it is the active and/or toxic compound. Although there is an obvious need for an adapted posology in patients with liver diseases, only suggestions can be drawn from presently limited data.
mesh_terms: D001646:Bile / Q000378:metabolism; D001660:Biliary Tract Diseases / Q000378:metabolism*; D001711:Biotransformation; D002779:Cholestasis / Q000378:metabolism; D006801:Humans; D008107:Liver Diseases / Q000378:metabolism*; D004364:Pharmaceutical Preparations / Q000378:metabolism*
chemical_list: D004364:Pharmaceutical Preparations
vernacular_title: Effets des maladies du foie et des voies biliaires sur le métabolisme des médicaments.