title: Convulsive thresholds and the activity of anticonvulsants in electroseizure test. The role of serotoninergic system.
abstract: The effect of different compounds modifying the activity of serotoninergic system on the convulsive threshold and on anticonvulsant action of phenyltoin (PHEN) phenobarbital (PHB), m-bromophenyl succinimide (BPHSI) and acetazolamide (ACA) in electroseizure test was studied. The obtained results suggest that 5-HT plays a significant role in the convulsive threshold and in ACA anticonvulsant action. No correlation, however, was observed between anticonvulsant action of the studied drugs and their influence on 5-HT level in brain.
mesh_terms: D000818:Animals; D000927:Anticonvulsants / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D001923:Brain Chemistry / Q000187:drug effects; D004298:Dopamine / Q000378:metabolism; D004597:Electroshock; D006897:Hydroxyindoleacetic Acid / Q000032:analysis; D008297:Male; D051379:Mice; D009638:Norepinephrine / Q000378:metabolism; D011955:Receptors, Drug / Q000187:drug effects; D012640:Seizures / Q000503:physiopathology*; D012701:Serotonin / Q000032:analysis / Q000378:metabolism / Q000502:physiology*
chemical_list: D000927:Anticonvulsants; D011955:Receptors, Drug; D012701:Serotonin; D006897:Hydroxyindoleacetic Acid; D004298:Dopamine; D009638:Norepinephrine