The synthesis of prostaglandin analogs containing the (hydroxycyclooctylidene)methyl ring system.
The synthesis of prostaglandin analogs incorporating the (2-hydroxycyclooctylidene)methyl moiety in place of the natural C13-C20 sidechain has been accomplished via copper-assisted conjugate addition of the (cyclooctylidene)methyllithium 5 to the cyclopentenone intermediates 7 and 10.
D055598:Chemical Phenomena; D002621:Chemistry; D003516:Cycloparaffins / Q000138:chemical synthesis; D011453:Prostaglandins / Q000138:chemical synthesis*
D003516:Cycloparaffins; D011453:Prostaglandins