title: Subchronic inhalation toxicity of azinphos-methyl in rats.
abstract: Azinphos-methyl was evaluated for its subchronic inhalation toxicity. The exposure of rats to concentrations of 0.195, 1.24, and 4.72 mg/m3, respectively, for 12 weeks, 6 hrs daily, 5 times weekly, resulted in effects only in those animals which inhaled aerosols of the highest concentration. This group showed a significant depression of the cholinesterase activity in plasma and erythrocytes. The males of this group had a lower body weight gain. The results are in agreement with the established maximum allowable concentration of 0.2 mg/m3.
mesh_terms: D000336:Aerosols; D000393:Air Pollutants / Q000633:toxicity; D000818:Animals; D001387:Azinphosmethyl / Q000633:toxicity*; D001835:Body Weight / Q000187:drug effects; D002802:Cholinesterases / Q000097:blood; D005260:Female; D007306:Insecticides / Q000633:toxicity*; D008297:Male; D008452:Maximum Allowable Concentration; D051381:Rats
chemical_list: D000336:Aerosols; D000393:Air Pollutants; D007306:Insecticides; D001387:Azinphosmethyl; D002802:Cholinesterases