Adrenergic and cholinergic stimulation and blockade of the human bladder base.
The response of muscle strips from the human anterior and posterior bladder base to autonomic stimulation and blockade was studied. The human bladder base, like that of the dog, possesses an abundance of cholinergic and alpha-adrenergic receptor sites. Neuropharmacologically, the musculature of the anterior base is similar to that of the posterior base (trigone plus detrusor musculature).
D000109:Acetylcholine / Q000494:pharmacology; D001341:Autonomic Nervous System / Q000502:physiology; D001665:Binding Sites; D006801:Humans; D066298:In Vitro Techniques; D009119:Muscle Contraction; D009130:Muscle, Smooth / Q000294:innervation; D009388:Neostigmine / Q000494:pharmacology; D009638:Norepinephrine / Q000494:pharmacology; D011941:Receptors, Adrenergic / Q000187:drug effects; D011950:Receptors, Cholinergic / Q000187:drug effects; D001743:Urinary Bladder / Q000187:drug effects / Q000294:innervation*
D011941:Receptors, Adrenergic; D011950:Receptors, Cholinergic; D009388:Neostigmine; D000109:Acetylcholine; D009638:Norepinephrine