The serotonin retaining effect of lithium in the rat thyroid.
The hypothesis of a lithium induced serotonin retention in the rat thyroid has been tested. It has been found that the thyroid in rats treated with lithium contains double the amount of serotonin compared with glands from untreated animals. The ability of TSH to stimulate serotonin release is inhibited by lithium. The ability of serotonin to stimulate thyroid hormone secretion in vitro is documented. The inhibitory action of lithium on both TSH and serotonin stimulation of hormone release is documented. The serotonin retaining effect of lithium as part of the goitrogenic effect of this ion is discussed.
D000818:Animals; D008094:Lithium / Q000494:pharmacology*; D008297:Male; D008856:Microscopy, Fluorescence; D051381:Rats; D012636:Secretory Rate / Q000187:drug effects; D012701:Serotonin / Q000378:metabolism* / Q000494:pharmacology; D013961:Thyroid Gland / Q000187:drug effects / Q000378:metabolism*; D013972:Thyrotropin / Q000494:pharmacology; D013974:Thyroxine / Q000494:pharmacology
D012701:Serotonin; D013972:Thyrotropin; D008094:Lithium; D013974:Thyroxine