title: Transnasal hypophysectomy.
abstract: A transnasal trans-sphenoidal surgical approach to the pituitary gland is described. The operative and post-operative experiences with the use of this technique on 21 patients with hormone-dependent malignant disease are reported. In 2 patients the procedure was abandoned because of intrasellar haemorrhage and in 1 an empty sella was found. Fifteen patients developed diabetes insipidus and 1 patient died in the postoperative period.
mesh_terms: D000328:Adult; D000368:Aged; D001943:Breast Neoplasms / Q000628:therapy; D003919:Diabetes Insipidus / Q000209:etiology; D005260:Female; D006801:Humans; D007016:Hypophysectomy / Q000009:adverse effects / Q000379:methods*; D008297:Male; D008875:Middle Aged; D009666:Nose; D011471:Prostatic Neoplasms / Q000628:therapy; D012075:Remission, Spontaneous