Lack of amyloidosis and renal disease in A strain mice.
Amyloid deposition in two sublines of the A strain mouse, a reputedly reliable murine model of spontaneous amyloidosis, was reevaluated using combined green polarization birefringence after Congo red staining and a fibrillar ultrastructure for amyloid identification. Both sublines were found to be devoid of amyloid at an age when the A strain mouse had been reported to have a high incidence of papillonephritis, amyloidosis, and death. This finding indicates a need for reassessment of this and other traditional models of spontaneous amyloidosis.
D000311:Adrenal Glands / Q000473:pathology; D000686:Amyloidosis / Q000473:pathology*; D000818:Animals; D003224:Congo Red; D003238:Connective Tissue / Q000648:ultrastructure; D003239:Connective Tissue Cells; D004195:Disease Models, Animal / Q000473:pathology*; D005189:False Positive Reactions; D005260:Female; D006651:Histocytochemistry; D007668:Kidney / Q000473:pathology; D007674:Kidney Diseases / Q000473:pathology*; D008297:Male; D051379:Mice; D008805:Mice, Inbred A; D012376:Rodent Diseases / Q000473:pathology*; D014059:Tongue / Q000473:pathology
D003224:Congo Red