Inhibitory effect of histone on the peroxidase activity of the Hp/Hb complex.
The human leukocyte nuclear histones can bind to haptoglobin (Hp), and thus interfere with subsequent binding of Hb. The Hp/Hb complex possesses peroxidase activity, but a Hp/histone complex does not. The inhibitory effect of histone molecules depends directly on the Hp and Hb, as well as the histone concentrations. The biological significance of the complex Hp/Hb as a measure of intravascular hemolysis and the interference of histones in this assay is briefly discussed.
D006242:Haptoglobins / Q000378:metabolism*; D006454:Hemoglobins / Q000378:metabolism*; D006657:Histones / Q000097:blood / Q000494:pharmacology*; D006801:Humans; D066298:In Vitro Techniques; D010544:Peroxidases / Q000037:antagonists & inhibitors*; D011485:Protein Binding / Q000187:drug effects
D006242:Haptoglobins; D006454:Hemoglobins; D006657:Histones; D010544:Peroxidases