[Inhibitor participation in the regulation of serum RNAse activity in the formation of immunity against influenza].
It was shown that parenteral administration of lead ions caused in the blood serum of albino mice a significant decrease in the amount of the bound RNA-ase 1 inhibitor and a simultaneous increase in the activity of this enzyme. Consequently, this inhibitor served as a regulator of the serum RNA-ase 1 activity. A considerable increase in the amount of the bound and free RNA-ase 1 inhibitor was noted in the serum in the process of triple immunization of persons with live influenza vaccine; this was accompanied by a significant reduction of the free RNA-ase 1 activity. This indicated that along with other mechanisms the inhibitor apparently participated in the processes of formation of immunity against influenza.
D000293:Adolescent; D000818:Animals; D000914:Antibodies, Viral / Q000032:analysis; D001666:Binding Sites, Antibody; D005609:Free Radicals; D006801:Humans; D007109:Immunity; D007114:Immunization; D007251:Influenza, Human / Q000276:immunology*; D051379:Mice; D010919:Placebos; D011485:Protein Binding; D012260:Ribonucleases / Q000037:antagonists & inhibitors*; D013053:Spectrophotometry; D013997:Time Factors
D000914:Antibodies, Viral; D005609:Free Radicals; D010919:Placebos; D012260:Ribonucleases
Uchastie ingibitora v reguliatsii aktivnosti syvorotochnoĭ RNK-azy pri formirovanii imuniteta protiv grippa