Studies on the acid secretion that occurs during injury to the gastric mucosa.
When pouches of the oxyntic glandular mucosa in dogs were irrigated with 4mM dithiothreitol in acid solution the mucosa shed plasma and secreted acid. There was a linear relationship between the net addition of H+ to the lumen and the amount of plasma shed, suggesting that the mechanisms of acid secretion and plasma shedding were closely related. Atropine, metiamide, and PGE2 only partially inhibited the acid secretion. The three drugs also reduced the plasma shedding and may be useful in the management of protein-losing gastropathy in man.
D000818:Animals; D001285:Atropine / Q000494:pharmacology; D002463:Cell Membrane Permeability / Q000187:drug effects; D004229:Dithiothreitol / Q000009:adverse effects; D004285:Dogs; D005745:Gastric Acidity Determination; D005750:Gastric Juice / Q000378:metabolism*; D005753:Gastric Mucosa / Q000187:drug effects / Q000293:injuries* / Q000378:metabolism; D006859:Hydrogen / Q000378:metabolism; D008785:Metiamide; D010949:Plasma / Q000378:metabolism; D011458:Prostaglandins E / Q000494:pharmacology; D012636:Secretory Rate / Q000187:drug effects; D012964:Sodium / Q000378:metabolism; D014882:Water-Electrolyte Balance / Q000187:drug effects
D011458:Prostaglandins E; D008785:Metiamide; D001285:Atropine; D006859:Hydrogen; D012964:Sodium; D004229:Dithiothreitol