Vinyl chloride-induced depression of hepatic non-protein sulfhydryl content and effects on bromosulphalein (BSP) clearance in rats.
Rats were exposed to atmospheres of 2000, 1000, 250, 150, 50 and 10 ppm vinyl chloride (VC) for 1-7 h to determine the effect of VC on the hepatic non-protein sulhydryl content, Exposure to 2000, 1000, 250 and 150 ppm VC caused a progressive depression of the hepatic non-protein sulfhydryl content. Following exposure to 50 ppm VC for 7 h the depression was inconsistent, and no depression was observed after 10 ppm VC for 7 h. Also, exposure to 1000 ppm VC did not alter the serum clearance of bromosulphalein (BSP).
D000818:Animals; D003864:Depression, Chemical; D008099:Liver / Q000187:drug effects / Q000378:metabolism*; D008111:Liver Function Tests; D008297:Male; D051381:Rats; D013438:Sulfhydryl Compounds / Q000378:metabolism*; D013448:Sulfobromophthalein / Q000378:metabolism*; D013997:Time Factors; D014752:Vinyl Chloride / Q000494:pharmacology*; D014753:Vinyl Compounds / Q000494:pharmacology*
D013438:Sulfhydryl Compounds; D014753:Vinyl Compounds; D013448:Sulfobromophthalein; D014752:Vinyl Chloride