Oral terbutaline sulfate--amelioration of exercise-induced bronchospasm.
Bronchospasm can be induced in asthmatics when exercised according to a multistage branching treadmill protocol that allows them to achieve 80 per cent of their age-predicted maximal heart rate. This present study was undertaken to investigate the effect of oral terbutaline sulfate in ameliorating exercise-induced bronchospasm. Ten asthmatics were exercised, and FEV1.0 and MMEFR were assessed while standing, using a Jones Pulmonar II waterless spirometer at 5, 15, and 30 minutes after exercise. Three hours before exercise, the subjects received no medication, oral placebo, or 5 mg terbutaline sulfate orally. At all time intervals after exercise, the pulmonary function of the group pretreated with oral terbutaline was superior when compared to the no-medication group (P less than 0.01) and to the placebo-treated group (P less than 0.05). Oral terbutaline appeared to normalize the exercise tolerance of the asthmatics and restore physiologic pulmonary airway conductance by the parameters of FEV1.0 and MMEFR.
D000284:Administration, Oral; D000328:Adult; D001249:Asthma / Q000188:drug therapy; D001986:Bronchial Spasm / Q000188:drug therapy*; D005541:Forced Expiratory Volume; D006801:Humans; D008450:Maximal Midexpiratory Flow Rate; D008875:Middle Aged; D005082:Physical Exertion; D010919:Placebos; D013726:Terbutaline / Q000008:administration & dosage / Q000627:therapeutic use*; D013997:Time Factors
D010919:Placebos; D013726:Terbutaline