title: Two new antibiotics, A-218 and K-41. Isolation and characterization.
abstract: Two new antibiotics, A-218 and K-41, were isolated from strains identified as Streptomyces hygroscopicus. The antibiotics are characterized as polycyclic polyether compounds and are active against gram-positive bacteria.
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000096:biosynthesis / Q000302:isolation & purification / Q000494:pharmacology; D001419:Bacteria / Q000187:drug effects; D002264:Carboxylic Acids / Q000302:isolation & purification; D004987:Ethers / Q000302:isolation & purification; D051379:Mice; D012995:Solubility; D013290:Streptococcal Infections / Q000188:drug therapy; D013302:Streptomyces / Q000378:metabolism
chemical_list: D000900:Anti-Bacterial Agents; D002264:Carboxylic Acids; D004987:Ethers