Is feminine differentiation of the brain hormonally determined?
The androgen insensitive, genetically male rat pseudohermaphrodite displays neither masculine or feminine sexual behavior when primed with the appropriate sex hormones. Although in the absence of androgen imprinting the animal develops anatomically as female, our results suggest that feminine differentiation of the brain requires active imprinting by perinatal hormone(s), possibly adrenal progesterone.
D000818:Animals; D000831:Animals, Newborn; D001921:Brain / Q000187:drug effects*; D002369:Castration; D012734:Disorders of Sex Development / Q000503:physiopathology; D004958:Estradiol / Q000494:pharmacology; D005260:Female; D005262:Feminization; D012739:Gonadal Steroid Hormones / Q000494:pharmacology*; D006801:Humans; D008297:Male; D011187:Posture; D011374:Progesterone / Q000494:pharmacology; D012733:Sex Differentiation / Q000187:drug effects*; D012726:Sexual Behavior, Animal / Q000187:drug effects*; D013739:Testosterone / Q000494:pharmacology
D012739:Gonadal Steroid Hormones; D013739:Testosterone; D011374:Progesterone; D004958:Estradiol