The effect of hypertonic ointments on corneal alkali burns.
Alkali-burned rabbit corneas were treated with 40% glucose or 5% sodium chloride ophthalmic ointments 3 times daily for 6 weeks and examined clinically and histologically. Treatment with hypertonic ointment as compared to untreated controls demonstrated decreased corneal neovascularization and ulceration. The possible nutritional advantage of hypertonic glucose did not prove beneficial compared to hypertonic sodium chloride.
D000468:Alkalies / Q000009:adverse effects*; D000818:Animals; D002057:Burns, Chemical / Q000150:complications / Q000188:drug therapy*; D002386:Cataract / Q000139:chemically induced; D003315:Cornea / Q000098:blood supply; D065306:Corneal Injuries; D003320:Corneal Ulcer / Q000139:chemically induced; D004487:Edema / Q000139:chemically induced; D005069:Evaluation Studies as Topic; D005126:Eye Burns / Q000150:complications / Q000188:drug therapy*; D005654:Fundus Oculi; D005947:Glucose / Q000627:therapeutic use*; D009824:Ointments; D011817:Rabbits; D012965:Sodium Chloride / Q000627:therapeutic use*
D000468:Alkalies; D009824:Ointments; D012965:Sodium Chloride; D005947:Glucose