Human breast tumour-induced osteolysis and prostaglandins.
Osteolysis effected in vitro by breast carcinomas can be inhibited by aspirin. Some prostaglandins stimulate in vitro bone resorption. Our results indicate that whilst osteolytically active PGE and PGF are released by the carcinomas in most cases, some other osteolytic principle is released as well.
D001241:Aspirin / Q000627:therapeutic use; D001862:Bone Resorption / Q000209:etiology*; D001943:Breast Neoplasms / Q000150:complications* / Q000378:metabolism; D005260:Female; D006801:Humans; D007213:Indomethacin / Q000494:pharmacology; D010014:Osteolysis / Q000188:drug therapy / Q000209:etiology* / Q000378:metabolism; D011453:Prostaglandins / Q000378:metabolism*; D011454:Prostaglandins A / Q000378:metabolism; D011458:Prostaglandins E / Q000378:metabolism; D011460:Prostaglandins F / Q000378:metabolism
D011453:Prostaglandins; D011454:Prostaglandins A; D011458:Prostaglandins E; D011460:Prostaglandins F; D001241:Aspirin; D007213:Indomethacin