The effect of sodium taurocholate on biliary iodipamide excretion in the dog.
The effect of sodium taurocholate in stepwise increasing infusion rates, 0.3 to 9.6 mumoles per min per kg, on the biliary excretion rate of iodipamide was investigated in 6 dogs (10 experiments) with complete bile diversion under general anesthesia. Iodipamide was administered intravenously with an initial priming dose of 33 mumoles per kg followed by a constant infusion of 1.3 mumoles per min per kg. Although the bile flow continuously increased with an increasing taurocholate dose, the iodipamide excretion rate reached a plateau with a 0.6 mumoles per min per kg of taurcholate infusion, which was 20% higher than with the lowest taurocholate dose. With a taurocholate dose over 2.4 mumoles per min per kg, a significant decrease in the iodipamide rate was found, amounting to 22% of its maximum value with the largest taurocholate dose. The bile iodipamide concentration was already at its maximum with the lowest taurocholate dose, and it decreased with an increasing taurocholate dose. Since the bile iodipamide concentration is probably the most important determinant in clinical cholangiography, low bile salt plasma levels should result in the best radiographic visualization of the biliary tree.
D000818:Animals; D001646:Bile / Q000378:metabolism*; D001692:Biological Transport; D002758:Cholangiography; D004285:Dogs; D004305:Dose-Response Relationship, Drug; D007458:Iodipamide / Q000008:administration & dosage / Q000378:metabolism*; D008099:Liver / Q000378:metabolism; D008297:Male; D013656:Taurocholic Acid / Q000008:administration & dosage / Q000494:pharmacology*
D013656:Taurocholic Acid; D007458:Iodipamide