[Allergic delayed reactions of the skin: the role of the antigen histotopy].
Delayed skin reaction to tuberculin were elicited in 10 healthy persons by patch testing and intracutaneous application of the antigen (Tine-Test). Biopsies revealed basically identical tissue reactions. After intracutaneous injection of the antigen as well as after Tine-testing the changes were solely found in the dermis, while after patch testing dermal and epidermal alterations were prominent. The type of response elicited by the same allergen in man-the so called tuberculin type of the eczematous type-therefore are due to a differential localization of the antigen.
D004485:Eczema; D004487:Edema; D006801:Humans; D006968:Hypersensitivity, Delayed / Q000276:immunology / Q000473:pathology*; D012867:Skin / Q000473:pathology; D012882:Skin Tests; D014374:Tuberculin Test
Allergische Spätreaktionen der Haut: die Rolle der Antigenhistotopie