Effect of metyrapone on cortisol binding capacity in plasma.
Metyrapone was added in vivo to six different samples of normal plasma (0.1 mg/ml plasma) and administered orally (30 mg/kg) to 5 adrenalectomized patients. An increased ratio free, non protein-bound cortisol: total cortisol in plasma was demonstrated after metyrapone in all six in vitro studies and in 4 of the 5 adrenalectomized patients. These findings may explain the accelerating effect of metyrapone on cortisol metabolism.
D000315:Adrenalectomy; D006801:Humans; D006854:Hydrocortisone / Q000097:blood*; D008797:Metyrapone / Q000494:pharmacology*; D012709:Serum Albumin / Q000378:metabolism; D014156:Transcortin / Q000378:metabolism
D012709:Serum Albumin; D014156:Transcortin; D006854:Hydrocortisone; D008797:Metyrapone