Angiotensin II metabolism and blood pressure in chronic renal disease.
A direct positive correlation has been found between mean blood pressure (MBP) and angiotensin II metabolic clearance rate (AII MCR) (p is less than 0.001) in 12 hypertensive patients with chronic renal disease (CRD) while it is not discernible in nine normals. A strong positive correlation appears between angiotensin II arterio-venous extraction (AII E) and total peripheral resistance in the two groups when analysed both jointly or separately (p is less than 0.001 in all instances). As MBP equals cardiac output (CO) x TPR and AII MCR equals CO x AII E percent, the only parameter which makes the two groups different in the relation MBP/AII MCR is the impairment of CO autoregulation in CRD cases. AII peripheral extraction and degradation is closely linked to the control of peripheral vascular resistance in the two groups.
D000804:Angiotensin II / Q000378:metabolism*; D001794:Blood Pressure; D002302:Cardiac Output; D006801:Humans; D007674:Kidney Diseases / Q000378:metabolism / Q000503:physiopathology*; D014655:Vascular Resistance
D000804:Angiotensin II