U-43,120; a new antitumor antibiotic. I. Production, biological activity, microbiological assay and taxonomy of the producing microorganism.
A new antitumor antibiotic, U-43,120 was discovered. It is produced by fermentation of a new species of Streptomyces, designated Streptomyces paulus DIETZ sp. n. Its antimicrobial activity is limited to bacteria. A microbiological assay with Bacillus subtilis was developed that can be detect concentrations of 1 approximately 2 mug/ml of the drug in fermentation liquors. U-43,120 was active in vivo against P-388 leukemia in mice.
D000818:Animals; D000903:Antibiotics, Antineoplastic / Q000096:biosynthesis / Q000494:pharmacology / Q000627:therapeutic use; D001419:Bacteria / Q000187:drug effects; D005285:Fermentation; D007942:Leukemia, Experimental / Q000188:drug therapy; D051379:Mice; D013302:Streptomyces / Q000145:classification / Q000254:growth & development / Q000378:metabolism; D013997:Time Factors
D000903:Antibiotics, Antineoplastic