A comparison of three ventricles used for left ventricular bypass in the calf.
Long-term synchronized left ventricular bypass has been performed in calves using pneumatically powered pumps having a smooth lining fabricated of segmented polyurethane. Three different pump designs have been employed: a) sac pump, b) longitudinal tethered sac pump, and c) transverse tethered sac pump. Sizeable thrombi occurred in the apex of the sac and longitudinal tethered sac pumps. In the transverse tethered sac pumps, a considerably smaller thrombus was seen only at the flexion point on the inlet side of the pump. Thrombi occurred in areas of low flow velocity and were not prevented by anticoagulation or surface coating techniques. This study indicates the importance of ventricle design in the development of thrombus free pumps and suggests modifications to the present pumps to reduce or eliminate thrombus formation.
D000818:Animals; D001243:Assisted Circulation / Q000295:instrumentation*; D001698:Biomedical Engineering; D001777:Blood Coagulation; D002404:Catheterization; D002417:Cattle; D006354:Heart, Artificial / Q000295:instrumentation*