Copper supplementation in quaking mutant mice: reduced tremors and increased brain copper.
Mice homozygous for the mutant gene quaking (qk) with a high frequency of axial tremors had a low concentration of copper in the brain. Supplementation during pregnancy and lactation with a high level of dietary copper greatly reduced the frequency of tremors and brought brain copper level to normal in the off-spring. It is suggested that qk affects copper metabolism.
D000818:Animals; D001921:Brain / Q000033:anatomy & histology / Q000378:metabolism*; D003300:Copper / Q000378:metabolism / Q000627:therapeutic use*; D005260:Female; D007774:Lactation; D051379:Mice; D009154:Mutation; D009929:Organ Size; D011247:Pregnancy; D014202:Tremor / Q000178:diet therapy* / Q000235:genetics / Q000378:metabolism
D003300:Copper