title: The development of myocardial changes during intermittent high altitude hypoxia in rats.
abstract: The initial phase and the development of myocardial focal necroses were studied in 50 rats adapted successively to intermittent high altitude. The altitude hypoxia was produced in a low pressure chamber (7000 m, five days a week, four hours daily). First-minute myocardial changes detected by histochemical methods were found after 4 exposures at a level of 3000 m and distinct ones after 8 exposures at a level of 4500 m. Histologically, acute focal necroses were found after 11 exposures at a level of 6000 m. Hypoxia and stress are suggested to account for these myocardial focal changes. During further adaptation no further acute focal necroses were observed.
mesh_terms: D000135:Acid Phosphatase / Q000378:metabolism; D000531:Altitude; D000818:Animals; D009202:Cardiomyopathies / Q000201:enzymology / Q000209:etiology*; D000860:Hypoxia / Q000150:complications* / Q000201:enzymology; D008297:Male; D009336:Necrosis; D051381:Rats; D013385:Succinate Dehydrogenase / Q000378:metabolism
chemical_list: D013385:Succinate Dehydrogenase; D000135:Acid Phosphatase