Effects of prostaglandin E1 and indomethacin on the stimulation-evoked overflow of 3H-noradrenaline from guinea-pig taenia.
Prostaglandin E1 (5.8 X 10(-8) M) markedly and reversibly reduced the stimulation-evoked overflow of total tritium, while it had no effects on basal outflow. Indomethacin (8.4 X 10(-6) M) increased the stimulation-evoked overflow of total tritium at low frequencies (2--5 HZ), while it had no effect at high frequencies of stimulation (more than 10 HZ). It was concluded that endogenous prostaglandin E1 also plays a regulatory role in adrenergic inhibitory neurotransmission by inhibiting the noradrenaline release from adrenergic nerve terminals of the guinea-pig taenia caecum.
D000818:Animals; D002432:Cecum / Q000187:drug effects / Q000378:metabolism*; D004558:Electric Stimulation; D006168:Guinea Pigs; D066298:In Vitro Techniques; D007213:Indomethacin / Q000494:pharmacology*; D008297:Male; D009638:Norepinephrine / Q000378:metabolism*; D011458:Prostaglandins E / Q000494:pharmacology*; D013997:Time Factors
D011458:Prostaglandins E; D009638:Norepinephrine; D007213:Indomethacin