[Correlation of tetratogenic and antimitotic activity of a number of derivatives of 2,4-diaminopyrimidine].
The effect of 6 substances, analogues of the antimalarial drug chloridine, on the mitotic activity of liver cells in rat embryos and cells of corneal epithelium in adult rats has been studied. A definite correlation was established between the antimitotic activity and the chemical structure of the drugs under study, and namely the length of alkyl radical in the position 6 of pyrimidine ring. The full correlation was noted between the teratogenic and antimitoic activities of these drugs.
D000014:Abnormalities, Drug-Induced / Q000473:pathology*; D000818:Animals; D003315:Cornea / Q000166:cytology; D004622:Embryo, Mammalian / Q000166:cytology; D005260:Female; D008099:Liver / Q000166:cytology; D008938:Mitosis / Q000187:drug effects*; D008940:Mitotic Index / Q000187:drug effects; D011247:Pregnancy; D011739:Pyrimethamine / Q000009:adverse effects / Q000031:analogs & derivatives* / Q000494:pharmacology; D051381:Rats
D011739:Pyrimethamine
O korreliatsii teratogennoĭ i antimitoticheskoĭ aktivnosti riada proizvosnykh 2,4-diaminopirimidina