title: Reversible and irreversible glucose disposal in dogs: influence of fasting and cold exposure.
abstract: Rates of total glucose entry rate, irreversible loss, and recycling were measured in unanesthetized dogs with indwelling arterial and venous catheters. Four experimental conditions were selected: 16 or 26 hr of fasting and neutral (+25 degrees C) or cold (-21 degrees C) ambient temperatures. A mixture of U 14C-glucose and 2-3H-glucose was used as a tracer, according to the primed infusion technique. No matter what the ambient temperature was, increase of fasting time from 16 to 26 hr induced a slight, but nonsignificant, decrease in both the total glucose entry rate and the irreversible loss. At neutral ambient temperature, the amount of glucose promptly recycled was less after 16 hr than after 26 hr of fasting, while an opposite pattern was observed during cold exposure. Thus, that part of hepatic glucose entry promptly recycled was significantly increased from 22% (16 hr of fasting) to 31% (26 hr of fasting) at neutral ambient temperature. It remained almost unchanged (20% and 18%) in cold. It was, therefore, suggested that this increase might be considered as an compensatory mechanism, exerting a sparing effect on glucose utilization. This mechanism does not occur in cold ambient temperature, thus, worsening a possible shortage in glucose supply.
mesh_terms: D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D003080:Cold Temperature; D004285:Dogs; D005215:Fasting; D005260:Female; D005947:Glucose / Q000378:metabolism*; D010084:Oxidation-Reduction; D010100:Oxygen; D012768:Shivering; D013997:Time Factors
chemical_list: D001786:Blood Glucose; D005947:Glucose; D010100:Oxygen