title: [Metabolism of fibrinogen in the cirrhotic patient. Dynamic study by isotope method].
abstract: The authors studied the metabolism of fibrinogen labelled with iodine 125 in 57 cirrhotic patients and 25 controls. Their results show that if the 82 subjects are grouped according to biological period values (T) and plasma pool (N.I.) of each of them, 4 distinct populations emerge. In each  of these 4 groups a physiopathological interpretation of fibrinogen metabolism may be proposed. In the context of consumption coagulopathies in cirrhosis, the examination is of real value and offers an objective criterion of therapeutic effectiveness.
mesh_terms: D001683:Biological Clocks; D004211:Disseminated Intravascular Coagulation / Q000188:drug therapy / Q000503:physiopathology; D005340:Fibrinogen / Q000378:metabolism*; D006493:Heparin / Q000627:therapeutic use; D006801:Humans; D007457:Iodine Radioisotopes; D008103:Liver Cirrhosis / Q000175:diagnosis / Q000378:metabolism* / Q000503:physiopathology
chemical_list: D007457:Iodine Radioisotopes; D005340:Fibrinogen; D006493:Heparin
vernacular_title: Métabolisme du fibrinogène chez le cirrhotique etude dynamique par méthode isotopique