[Biological effects of radiomimetic compounds: quantitative studies of changes in the urinary excretion of creatine and creatinine in rats treated with HN-2].
Urinary creatine and creatinine excretion in rats treated by HN-2 ("bb'-dichlorodiethyl-N-methylamine") has been studied as function of dose and time from administration. Experimental results obtained in treated animals show an increased urinary excretion for creatine and decreased urinary excretion for creatinine. The variations are correctly related with the dose. Observed modifications are compared with the informations about urinary creatine and creatinine excretion after ionizing radiations exposure. Within research bounds, experimental results let to regard studied compounds as a possible biological dose indicators in the HN-2 intoxication.
D000818:Animals; D003401:Creatine / Q000652:urine*; D003404:Creatinine / Q000652:urine*; D004305:Dose-Response Relationship, Drug; D008297:Male; D008744:Methylamines / Q000008:administration & dosage / Q000494:pharmacology*; D009153:Mutagens / Q000494:pharmacology*; D011832:Radiation Injuries / Q000652:urine; D051381:Rats
D008744:Methylamines; D009153:Mutagens; D003404:Creatinine; D003401:Creatine
Effetti biologici di composti ad azione radiomimetica. Studi quantitativi sulle modificazioni dell'escrezione urinaria di creatina e creatinina in ratti trattati con HN-2