title: [Course observations of hypertrophic obstructive myocardiopathy].
abstract: The course of HOCM is characterized by a slow progression. Symptoms can often be influenced favourably by medical treatment. Altogether there is some difference between the course of untreated and the propranolol-treated patient groups which is, however, not statistically significant. Furthermore, the rate of sudden death is uninfluenced. Comparing clinical and haemodynamic results in medicically treated patients we find a reduction of the outflow tract obstruction in case with clinical improvement but not a reduction of the enddiastolic pressure. Independent on the clinical course there was a significant increase of the enddiastolic pressure after 5.5 years. We may conclude that there is a progredient process of hypertrophy which is uninfluenced by the obstruction and by conservative management. The best results are obtained in the operated group. According to our results a surgical intervention should possibly be considereed more generously.
mesh_terms: D000293:Adolescent; D000328:Adult; D000367:Age Factors; D009202:Cardiomyopathies / Q000150:complications / Q000175:diagnosis* / Q000188:drug therapy / Q000601:surgery; D006350:Heart Valve Prosthesis; D006801:Humans; D008722:Methods; D008943:Mitral Valve; D008944:Mitral Valve Insufficiency / Q000150:complications; D011379:Prognosis; D011433:Propranolol / Q000627:therapeutic use; D013997:Time Factors
chemical_list: D011433:Propranolol
vernacular_title: Verlaufsbeobachtungen der hypertrophischen obstruktiven Myokardiopathie (HOCM)