Association between subcellular proliferating membranes and mitochondria in dog thyroid follicular cells induced by synthetic double-stranded RNA administration.
The administration of polyriboinosinic-polyribocytidylic acid [poly(rI:rC)], an interferon inducer and antitumour agent, induced proliferating intracellular membranes as well as a characteristic association between those membranes and mitochondria. The membrane-mitochondrion association was most often observed in small mitochondria lying close to the basal cell membrane. Although the meaning of this differential response is not known, these findings might be explained by an actual biogenesis of the mitochondria from subcellular membranes induced by poly (rI:rC), either directly or secondary to its toxic effects.
D000818:Animals; D002462:Cell Membrane / Q000187:drug effects*; D004285:Dogs; D004721:Endoplasmic Reticulum / Q000187:drug effects; D011070:Poly I-C / Q000494:pharmacology*; D013961:Thyroid Gland / Q000187:drug effects / Q000648:ultrastructure*
D011070:Poly I-C