Superiority of developed over total pressure for heart contractility indices in dogs.
The independence of indices of contractility to Starling effects was tested in 6 closed-chest dogs. After vagal and beta-receptors blockade, indices calculated with total left ventricular isometric pressure (TP), were shown to be strongly dependent of rises in end-diastolic pressure (LVEDP) induced by dextran infusion. At LVEDP of 14.6 +/- 1.5, 22.2 +/- 1.1 and 32.8 +/- 1.5 mm Hg (+/- SEM), the peak value of velocity of the contractile elements calculated with total pressure (peak VCE, TP) diminished by 21, 40 and 50%, and the extrapolated value of VCE, TP at zero total pressure (Vmax, TP) diminished by 15, 30 and 44%. In contrast, indices calculated with developed pressure (DP = TP-LVEDP) at the same LVEDP were much less influenced, particularly the extrapolated value of VCE, DP at zero DP (V max, DP5) and (peak dP/dt)/DP did not significantly change. During angiotensin infusion, expected decreases in TP indices secondary to LVEDP rises were partially masked by simultaneous increases in contractility, and DP indices tended to rise. On the  other hand, with minimal changes in LVEDP, as during calcium injection and paired stimulation, increases in TP and DP indices demonstrate inotropic effects equally well. Our study also shows that, besides Vmax calculated with DP, the instantaneous ratio of peak dP/dt and DP can also be proposed as a simpler and thus more convenient index of contractility independent of volume changes.
D000804:Angiotensin II / Q000494:pharmacology; D000818:Animals; D001285:Atropine; D001794:Blood Pressure; D002118:Calcium / Q000494:pharmacology; D002302:Cardiac Output; D002306:Cardiac Volume; D004285:Dogs; D006334:Heart Function Tests / Q000379:methods*; D009200:Myocardial Contraction / Q000187:drug effects; D011433:Propranolol; D016276:Ventricular Function
D000804:Angiotensin II; D001285:Atropine; D011433:Propranolol; D002118:Calcium