Collaborative study of a spectrophotometric determination of ferric, ferrous, and total iron in drugs by reaction with  alpha,alpha'-dipyridyl.
A spectrophotometric method for determining Fe2+, Fe3+, and total Fe in drugs has been developed, using alpha,alpha'-dipyridyl as the colorimetric reagent. The method is applicable to tablets elixirs, injectables, and bulk powder. Eight collaborates analyzed a synthetic iron preparation and 7 commercial samples. For the synthetic iron preparation, the average recovery was 100.3% and the coefficient of variation was 1.02%. For 7 commercial samples, the average coefficient of variation was 1.44%. The method has been adopted as official first action.
D015082:2,2'-Dipyridyl; D003124:Colorimetry; D005290:Ferric Compounds / Q000032:analysis; D005296:Ferrous Compounds / Q000032:analysis; D007202:Indicators and Reagents; D007501:Iron / Q000032:analysis*; D011208:Powders; D011725:Pyridines; D012996:Solutions; D013053:Spectrophotometry; D013607:Tablets
D005290:Ferric Compounds; D005296:Ferrous Compounds; D007202:Indicators and Reagents; D011208:Powders; D011725:Pyridines; D012996:Solutions; D013607:Tablets; D015082:2,2'-Dipyridyl; D007501:Iron