Blockade of the behavioral effects of 5-HTP by the decarboxylase inhibitor Ro 4-4602.
Twenty male rats were trained to press a bar on a fixed-ratio (FR 32) schedule of water reinforcement. The behavioral effects of 5-HTP (50 mg/kg) were studied following pretreatment with small (50 mg/kg) and large (400 mg/kg) doses of the decarboxylase inhibitor Ro 4-4602. It was found that both doses of the pretreatment agent blocked the disruptive effects of 5-HTP. This result suggests that at least some of the effects of 5-HTP may be mediated peripherally.
D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects*; D001545:Benserazide / Q000494:pharmacology*; D003216:Conditioning, Operant / Q000187:drug effects; D006834:Hydrazines / Q000494:pharmacology*; D008297:Male; D051381:Rats; D012702:Serotonin Antagonists; D013997:Time Factors
D006834:Hydrazines; D012702:Serotonin Antagonists; D001545:Benserazide