Topical cycloheximide in psoriasis.
Cycloheximide is an antimitotic and an inhibitor of the synthesis of both DNA and protein. Topical application in low concentrations (0.1%-0.2%) resulted in definite involution of psoriatic plaques. Because of its potency this experimental drug - not yet available for clinical use - was employed on small areas only and with extreme caution. Results of a full evaluation for safety, currently in progress, are being awaited with interest.
D000287:Administration, Topical; D055598:Chemical Phenomena; D002621:Chemistry; D003513:Cycloheximide / Q000008:administration & dosage* / Q000627:therapeutic use; D004341:Drug Evaluation; D006801:Humans; D011565:Psoriasis / Q000188:drug therapy*
D003513:Cycloheximide