Ultrastructural changes in dog thyroid follicular cells elicit by concanavalin A in vitro.
Dog thyroid follicular cells exposed to concanavalin A (Con A) in vitro showed changes in cell shape, induction of colloid droplets and alterations in the distribution of microvilli. Cells exposed to Con A plus suboptimal concentrations of TSH (thyroid stimulating hormone) showed pseudopods and their cytoplasm was virtually occupied with colloid droplets. This findings suggest that Con A potentiated pseudopod and colloid droplet formation induced by TSH.
D000818:Animals; D002478:Cells, Cultured; D003208:Concanavalin A / Q000494:pharmacology*; D004285:Dogs; D004357:Drug Synergism; D013961:Thyroid Gland / Q000166:cytology / Q000187:drug effects / Q000648:ultrastructure*; D013972:Thyrotropin / Q000494:pharmacology
D003208:Concanavalin A; D013972:Thyrotropin