title: [Clinical effects of a clonidine-chlorthalidone combination in the treatment of arterial hypertension].
abstract: Clonidine (0.075-0.225 mg/day) and chlorthalidone (0.15-0.45 mg/day) were associated in the management of 23 cases of arterial hypertension of varying nature and gravity. A significant and satisfactory decrease in pressure was accompanied by reduced cardiac frequency. Diuresis, body weight and the main biohumoral indices were not significantly affected. The mechanism of action of the two drugs is explained and the reason why success was obtained with their combination in less-than-normal doses is discussed.
mesh_terms: D000328:Adult; D002752:Chlorthalidone / Q000008:administration & dosage* / Q000009:adverse effects / Q000627:therapeutic use; D003000:Clonidine / Q000008:administration & dosage* / Q000009:adverse effects / Q000627:therapeutic use; D004341:Drug Evaluation; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D006973:Hypertension / Q000188:drug therapy*; D007022:Hypotension / Q000139:chemically induced; D008297:Male; D008875:Middle Aged; D012893:Sleep Wake Disorders / Q000139:chemically induced; D014717:Vertigo / Q000139:chemically induced
chemical_list: D003000:Clonidine; D002752:Chlorthalidone
vernacular_title: Effetti clinici dell'associazione clonidina-clortalidone nel trattamento della ipertensione arteriosa