title: Quality control in haemoglobinometry with special reference to the stability of haemiglobincyanide reference solutions.
abstract: In haemoglobinometry grave errors are still being made even though an internationally accepted standardized method is available for the determination of the haemoglobin content of blood. Up to the present only haemiglobincyanide reference solutions have been available on a wide scale to check the measuring stage of the standardized haemiglobincyanide method. These reference solutions are shown to remain stable, under proper storage conditions, for more than 10 years. Concentrated haemoglobin solutions have become available recently, offering the possibility to control the dilution and conversion steps of the haemiglobincyanide method. Such a solution is shown to remain stable, under proper storage conditions, for at least a year. Using both haemiglobincyanide reference solutions and concentrated haemoglobin solutions, as well as having the possibility of checking the cyanide content of the reagent used, an acceptable intra-laboratory control program may now be set up.
mesh_terms: D003486:Cyanides / Q000097:blood*; D004355:Drug Stability; D005069:Evaluation Studies as Topic; D006454:Hemoglobins / Q000032:analysis*; D006461:Hemolysis; D006801:Humans; D008722:Methods; D011786:Quality Control
chemical_list: D003486:Cyanides; D006454:Hemoglobins