Effect of hemorrhagic shock on intrapulmonary right-to-left shunt (QS/QT) and dead space (VD/VT).
The effect of hemorrhagic shock on intrapulmonary right-to-left shunt and dead space ratio was investigated in spontaneously breathing dogs under barbiturate anesthesia. Intrapulmonary right-to-left shunt was reduced sufficiently to offset the marked increase in arteriovenous oxygen difference and PaO2 did not fall. Dead space ratio was increased markedly; therefore, in shock, sufficient CO2-elimination depends on severe hyperventilation. According to this empirical findings, a decrease in PaO2 in shock must not be interpreted as a consequence of the shock itself, but it implies an additional pulmonary pathology.
D000818:Animals; D002245:Carbon Dioxide / Q000097:blood; D004285:Dogs; D008168:Lung / Q000503:physiopathology*; D010100:Oxygen / Q000097:blood; D010313:Partial Pressure; D011652:Pulmonary Circulation; D012119:Respiration; D012126:Respiratory Dead Space; D012771:Shock, Hemorrhagic / Q000503:physiopathology*; D014692:Ventilation-Perfusion Ratio
D002245:Carbon Dioxide; D010100:Oxygen