[Histocompatibility-(HLA) antigens in patients with HBsAg positive and negative hepatitis and healthy carriers of HBsAg and anti-HBs. (author's transl)].
New own data and a survey of published data concerning the frequencies of 23 HLA antigens in patients with HBsAg positive and negative chronic active hepatitis (CAH) and healthy carriers of Hepatitis-surface antigen (HBsAg) and high titers of antibodies to HBaAg (Anti-HBs) allow to conclude as follows: 1. Patients with CAH and persistence of HBsAg show a normal frequency of HLA-B8. 2. There is no increased frequency of HLA-B8 in HBsAg negative CAH without autoimmune antibodies. 3. Only in patients with HBsAg negative CAH with autoimmune antibodies is the frequency of HLA-B8 is statistically significantly increased (p less than 0.01 after correction for the number of antigens and different groups of patients compared). These are patients with the autoimmune form of CAH. 4. There exist no significant differences in the frequencies of the HLA antigens tested in patients with HBsAg positive CAH and healthy carriers of HBsAg and Anti-HBs. Thus no indications could be found for HLA-associated factors in the different behaviour to the hepatitis-B virus.
D000328:Adult; D001323:Autoantibodies / Q000032:analysis; D002353:Carrier State / Q000276:immunology*; D002908:Chronic Disease; D006680:HLA Antigens / Q000032:analysis*; D006505:Hepatitis / Q000276:immunology*; D006509:Hepatitis B / Q000276:immunology*; D006649:Histocompatibility Antigens / Q000032:analysis*; D006801:Humans
D001323:Autoantibodies; D006680:HLA Antigens; D006649:Histocompatibility Antigens
Histokompatibilitäts-(HLA) Antigene bei Patienten mit HBsAg-positiver und -negativer chronisch aktiver Hepatitis und gesunden Trägern von HBsAg und anti-HBs