[Extra-cardial rise of the CPK in the screening of urgent diagnostic (among others, a case of anaesthesia induced myoglobinuria and a case of malignant hypertermia) (author's transl)].
Tests are being carried out on 37 patients and healthy volunteers, to differentiate the various, from heart independent, creatin-phosphokinase (CPK) increases, in order to recognize anaesthesia-endangered patients. A rise of the serum-CPK-level, dependent on trauma is insignificant for the anaesthesia. A significant rise of the CPK during a gener al anaesthesia and particularly extreme high values after 24 hours, (example, more than 10 000 U/l) is reason to think of a course of a malignant hyperthermia or myoglobinuria in a subclinical form. Relatives of hyperthermia- or myoglobinuria suspected families are in all cases anaesthesia-endangered, even with a very small rise of CPK-values. The knowledge of these connections is highly important also for internal medical spheres.
D000208:Acute Disease; D000293:Adolescent; D000328:Adult; D000768:Anesthesia, General / Q000009:adverse effects*; D003402:Creatine Kinase / Q000097:blood*; D005260:Female; D006801:Humans; D008297:Male; D008305:Malignant Hyperthermia / Q000201:enzymology*; D009212:Myoglobinuria / Q000201:enzymology* / Q000209:etiology; D014947:Wounds and Injuries / Q000201:enzymology
D003402:Creatine Kinase
Extrakardiale CPK-Erhöhung im Screening der Notfalldiagnostik. Fälle von anästhesieinduzierter akuter Myoglobinurie und maligner Hyperthermie.