title: The effects of the sub-chronic administration of an anti-histamine, clemastine, on tests of car driving ability and psychomotor performance.
abstract: A double-blind placebo-controlled crossover trial was carried out in 21 normal volunteers to study the effects of sub-chronic administration of clemastine on car driving ability and psychomotor performance. Subjects were assessed on 5 tests representing various aspects of everyday car driving experience, and on subjective rating scales for mood, sleep, and psychomotor integration. The results showed that repeated doses of 1 mg clemastine b.d. for 3 days had no significant consistent effect on any of the parameters measured.
mesh_terms: D001334:Automobile Driving; D002974:Clemastine / Q000008:administration & dosage / Q000494:pharmacology*; D006801:Humans; D011581:Psychological Tests; D011759:Pyrrolidines / Q000494:pharmacology*
chemical_list: D011759:Pyrrolidines; D002974:Clemastine