Demethylation in rats chronically treated with cocaine.
Norcocaine was prepared from cocaine utilizing diethyl azodicarboxylate. The rate of demethylation of 14C-cocaine in rats receiving either chronic or acute dosages of the drug was investigated. No significant difference in the rate of 14CO2 exhalation from the two groups was observed.
D000818:Animals; D002245:Carbon Dioxide / Q000378:metabolism; D003042:Cocaine / Q000008:administration & dosage / Q000378:metabolism*; D008297:Male; D008861:Microsomes / Q000378:metabolism; D010089:Oxidoreductases, N-Demethylating / Q000378:metabolism; D051381:Rats
D002245:Carbon Dioxide; D010089:Oxidoreductases, N-Demethylating; D003042:Cocaine