[Changes in monoamine oxidase activity and catecholamine content in the tissues of guinea pigs saturated with ascorbic acid under the influence of actinomycin D, tetracycline and cycloheximide].
A short-time saturation of guinea pigs with ascorbic acid (100 mg per 1 kg of weight every hour for 5 h) causes its accumulation in the adrenals and blood, an increase in the monoaminooxidase activity in the liver and in the content of adrenaline in the adrenals. The content of noradrenaline in the liver and brain does not change. Inhibitors of protein synthesis, actinomycin D, tetracycline and cycloheximide, have a different effect on the increase in the monoaminooxidase activity evoked by introduction of ascorbic acid: tetracycline blocks the increase in the enzyme activity, actinomycin D has no effect on it. Cycloheximide introduced against a background of chronic saturation of guinea pigs with ascorbic acid also blocks the increase in the monoaminooxidase activity in the liver mitochondria.
D000311:Adrenal Glands / Q000201:enzymology; D000818:Animals; D001205:Ascorbic Acid / Q000378:metabolism*; D001921:Brain / Q000201:enzymology; D002395:Catecholamines / Q000378:metabolism*; D003513:Cycloheximide / Q000494:pharmacology*; D003609:Dactinomycin / Q000494:pharmacology*; D004347:Drug Interactions; D004789:Enzyme Activation / Q000187:drug effects; D004837:Epinephrine / Q000378:metabolism; D006168:Guinea Pigs; D008099:Liver / Q000201:enzymology; D008297:Male; D008995:Monoamine Oxidase / Q000378:metabolism*; D008996:Monoamine Oxidase Inhibitors / Q000494:pharmacology; D009638:Norepinephrine / Q000378:metabolism; D013752:Tetracycline / Q000494:pharmacology*; D013997:Time Factors
D002395:Catecholamines; D008996:Monoamine Oxidase Inhibitors; D003609:Dactinomycin; D003513:Cycloheximide; D008995:Monoamine Oxidase; D013752:Tetracycline; D001205:Ascorbic Acid; D009638:Norepinephrine; D004837:Epinephrine
Zminy monoaminoksydaznoï aktyvnosti ta vmistu katekholaminiv u tkanynakh mors'kykh svynok, nasychenykh askorbinovoiu kyslotoiu, pid vplyvom aktynomitsynu D, tetratsyklinu i tsykloheksymidu