title: [Effect of interferon inducers on the development of specific resistance to tick-borne encephalitis].
abstract: Various natural and synthetic interferon inducers stimulate postvaccination immunity to tick-borne encephalitis virus in mice. This capacity was found not only in macromolecular synthetic polyribonucleotides such as (poly I)-(poly C), (poly G)-(poly C), (poly A)-(poly U) and substances with  much lower molecular weight such as copolymers of vinylpyrrolidone with maleic anhydride, crotonic acid or metacrylic acid but also in a low molecular interferon inducer tiloron. These and other interferon inducers examined (endotoxin S-typhi, statolon) exhibited no parallelism between the intensity of their stimulating effect of immunogenesis and levels of interferon production induced in mice and the associated resistance to tick-borne encephalitis. The results indicate a possibliity of using various interferon inducers for stimulation of post-vaccination immunity to tick-borne encephalitis.
mesh_terms: D000818:Animals; D000917:Antibody Formation / Q000187:drug effects*; D004675:Encephalitis, Tick-Borne / Q000517:prevention & control*; D007369:Interferon Inducers / Q000627:therapeutic use*; D051379:Mice; D011063:Poly A-U / Q000627:therapeutic use; D011070:Poly I-C / Q000627:therapeutic use; D011134:Polysaccharides / Q000627:therapeutic use; D013994:Tilorone / Q000627:therapeutic use; D014611:Vaccination; D014765:Viral Vaccines
chemical_list: D007369:Interferon Inducers; D011134:Polysaccharides; D014765:Viral Vaccines; D011063:Poly A-U; D013994:Tilorone; D011070:Poly I-C
vernacular_title: Vliianie induktorov interferona na formirovanie spetsificheskoĭ rezistentnosti k kleshchevomu éntsefalitu