Preferential inhibition by poly(adenylic acid) of minus-strand synthesis by bacteriophage Qbeta ribonucleic acid replicase.
Among the homopolymers examined, poly(A) was found to inhibit preferentially the synthesis of the minus strand by bacteriophage Qbeta RNA replicase in the presence of host factor. A specific interaction of poly(A) with the host factor is suggested to be a principal cause for the observed preferential inhibition by poly(A) of the host-factor-requiring Qbeta RNA replicase reaction.
D000249:Adenosine Monophosphate / Q000494:pharmacology; D003090:Coliphages / Q000201:enzymology; D007700:Kinetics; D011061:Poly A / Q000494:pharmacology*; D011066:Poly C / Q000494:pharmacology; D011072:Poly U / Q000494:pharmacology; D012316:RNA Nucleotidyltransferases / Q000037:antagonists & inhibitors*; D012367:RNA, Viral / Q000096:biosynthesis*; D012324:RNA-Dependent RNA Polymerase / Q000037:antagonists & inhibitors*; D014764:Viral Proteins / Q000037:antagonists & inhibitors
D012367:RNA, Viral; D014764:Viral Proteins; D011061:Poly A; D011072:Poly U; D011066:Poly C; D000249:Adenosine Monophosphate; D012316:RNA Nucleotidyltransferases; D012324:RNA-Dependent RNA Polymerase