Clinical course and management of accidental adriamycin extravasation.
Adriamycin infiltration into subcutaneous tissues during intravenous administration results in an intense inflammatory response, which may progress to full-thickness skin ioss and irreversible damage to underlying tendons and neurovascular structures. An analysis of 10 patients seen with Adriamycin in filtration indicated that healing of ulcerated lesions is often prolnged and associated with significant morbidity. Seven patients suffered skin ulcerations and three had severe functional impairment due to joint contractures. Adriamycin should not be infused near joints if possible . Surgical excision of ulcers is advocated if healing is prolonged. Proper local therapy, as well as early attention to proper splinting and physical therapy, can help reduce ultimate functional disability.
D000293:Adolescent; D000328:Adult; D004317:Doxorubicin / Q000009:adverse effects*; D005260:Female; D006801:Humans; D007249:Inflammation / Q000139:chemically induced / Q000628:therapy; D007275:Injections, Intravenous / Q000009:adverse effects*; D007596:Joints / Q000187:drug effects; D008297:Male; D008875:Middle Aged; D009336:Necrosis / Q000139:chemically induced / Q000628:therapy; D012883:Skin Ulcer / Q000139:chemically induced / Q000628:therapy
D004317:Doxorubicin