title: Detection of receptors for immunoglobulin on human placenta by EA rosette formation.
abstract: Direct evidence for the existence of Fc receptors on the surface of first trimester and term human placental cells has been obtained by the use of an antibody-coated red cell (EA) rosette assay. The modification of a Ficoll density gradient separation procedure for placental cell population in conjunction with dye uptake experiments, cytocentrifuge preparations and cytological analysis has enabled an identification of the rosette-forming cells in the mature placenta as predominantly, if not entirely, syncytiotrophoblastic. The significance of these findings, together with those demonstrating the presence of cell-surface Fc receptors on the chorionic membrane, are considered in relation to the transmission of immunoglobulin from mother to foetus and to the protection of the foetus as an intra-uterine allograft.
mesh_terms: D002462:Cell Membrane / Q000276:immunology; D002469:Cell Separation; D002823:Chorion / Q000276:immunology; D005260:Female; D005865:Gestational Age; D006801:Humans; D007104:Immune Adherence Reaction; D007141:Immunoglobulin Fc Fragments; D010920:Placenta / Q000276:immunology*; D011247:Pregnancy; D011947:Receptors, Antigen, B-Cell
chemical_list: D007141:Immunoglobulin Fc Fragments; D011947:Receptors, Antigen, B-Cell