Cholinomimetic teratogens. III. Interaction with amino acids known as neurotransmitters.
The amino acids gamma-aminobutyric acid, taurocholate, guanidine, glycine, and beta-alanine, known to have putative functions as neurotransmitters, when given as supplement to carbachol or decamethonium, greatly reduced the incidence of malformations produced in chicken embryos by these depolarizing cholinomimetic teratogens. In combination with the nondepolarizing teratogens neostigmine and pyridostigmine similarly beneficial effects occurred only by supplementation with gamma-aminobutyric acid.
D000409:Alanine / Q000494:pharmacology; D000818:Animals; D002217:Carbachol / Q000633:toxicity; D002642:Chick Embryo; D003650:Decamethonium Compounds / Q000633:toxicity; D005260:Female; D005313:Fetal Death / Q000139:chemically induced; D005998:Glycine / Q000494:pharmacology; D006146:Guanidines / Q000494:pharmacology; D009388:Neostigmine / Q000633:toxicity; D010277:Parasympathomimetics / Q000633:toxicity*; D011247:Pregnancy; D011729:Pyridostigmine Bromide / Q000633:toxicity; D013656:Taurocholic Acid / Q000494:pharmacology; D013723:Teratogens / Q000037:antagonists & inhibitors*; D005680:gamma-Aminobutyric Acid / Q000494:pharmacology
D003650:Decamethonium Compounds; D006146:Guanidines; D010277:Parasympathomimetics; D013723:Teratogens; D009388:Neostigmine; D005680:gamma-Aminobutyric Acid; D013656:Taurocholic Acid; D002217:Carbachol; D011729:Pyridostigmine Bromide; D000409:Alanine; D005998:Glycine