Studies of possible absorption of a flame retardant from treated fabrics worn by rats and humans.
An investigation was made of the possible migration of a flame retardant, tris (2,3-dibromopropyl) phosphate (TBPP), commercially used in childrens sleepwear, to the skin of rats and humans and subsequent absorption. When the pure chemical was applied directly to the shaved skin of a rat, the hydrolysis product, 2,3-dibromopropanol (DBP), appeared in the urine. The 10,000 X g supernatant fraction of rat liver hydrolyzed TBPP to DBP. When TBPP-finished fabrics were worn by a rat, an adult male and a 5-year-old boy for up to 9 days, DBP was not detected in the urine.
D000818:Animals; D002675:Child, Preschool; D002849:Chromatography, Gas; D003020:Clothing; D006801:Humans; D006842:Hydrocarbons, Brominated / Q000378:metabolism / Q000652:urine; D066298:In Vitro Techniques; D008297:Male; D008862:Microsomes, Liver / Q000378:metabolism; D010755:Organophosphates / Q000378:metabolism* / Q000652:urine; D051381:Rats; D012869:Skin Absorption
D006842:Hydrocarbons, Brominated; D010755:Organophosphates; C012085:tris(2,3-dibromopropyl)phosphate