Penetration of phenylacetic acid across the blood-cerebrospinal fluid barrier.
Labeled phenylacetic acid (14C-PAA) penetrates blood-cerebrospinal fluid (CSF) barrier in cats only under a high gradient of concentration; under these conditions the administration of large doses of either PAA or probenecid decreases the plasma:CSF 14C-PAA ratio. 14C-PAA is quickly removed from the CSF and blood and is excreted into urine; this excretion is blocked by probenecid. It appears, therefore, that PAA crosses the blood-CSF barrier with difficulty and that is secreted by the kidney.
D000818:Animals; D001812:Blood-Brain Barrier; D002415:Cats; D005260:Female; D008297:Male; D010648:Phenylacetates / Q000378:metabolism*; D011339:Probenecid / Q000494:pharmacology; D013997:Time Factors
D010648:Phenylacetates; D011339:Probenecid