[Glutathione peroxidase and glutathione reductase activity in the rat liver after the administration of sodium selenite].
Sodium selenite 24h after its single administration to rats causes an increase in the activity of glutathione peroxidase and glutathione reductase in the liver tissue. 6 h after the selenium administration the enzymes activity does not differ from the control. Doses of 0.15, 0.3, 0.5 and 1 mg of selenium per 1 kg of the animal weight were investigated. 0.3 mg proved to be the least effective dose. An increase in the enzyme activity after administering 0.5 mg of selenium is retained for 6 days and 14 days after it does not differ from the control. The liver relative weight 24 h after administration of 0.5 mg of selenium per 1 kg of animal weight proved to be higher but three days later it did not differ from the control. After administering selenium in a dose of 1 mg/kg the liver relative weight was higher for 6 days. Actinomycin D administered in a dose of 0.5 mg/kg simultaneously with selenite prevents the rise in the enzyme activity and relative weight of the liver caused only by a single injection of selenium in the same dose.
D000818:Animals; D003609:Dactinomycin / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D004347:Drug Interactions; D004789:Enzyme Activation / Q000187:drug effects; D005260:Female; D005979:Glutathione Peroxidase / Q000378:metabolism*; D005980:Glutathione Reductase / Q000378:metabolism*; D008099:Liver / Q000187:drug effects / Q000201:enzymology*; D010544:Peroxidases / Q000378:metabolism*; D051381:Rats; D012643:Selenium / Q000494:pharmacology*; D013268:Stimulation, Chemical; D013438:Sulfhydryl Compounds / Q000378:metabolism; D013997:Time Factors
D013438:Sulfhydryl Compounds; D003609:Dactinomycin; D010544:Peroxidases; D005979:Glutathione Peroxidase; D005980:Glutathione Reductase; D012643:Selenium
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