Central mediated pressor effect by prostaglandins in the rat.
Extremely small concentrations (1 ng/kg/min) of prostaglandins E1, A1, and A2 elevated arterial blood pressure in the rat when infused into the carotid artery. Similar infusions into the femoral vein failed to demonstrate a pressor response. Higher concentrations of the same prostaglandins infused into the femoral vein resulted in a significant depression of blood pressure.
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects*; D002339:Carotid Arteries; D004305:Dose-Response Relationship, Drug; D005268:Femoral Vein; D007269:Injections, Intra-Arterial; D007275:Injections, Intravenous; D008297:Male; D011454:Prostaglandins A / Q000008:administration & dosage / Q000494:pharmacology*; D011458:Prostaglandins E / Q000008:administration & dosage / Q000494:pharmacology*; D051381:Rats
D011454:Prostaglandins A; D011458:Prostaglandins E