The influence of hepatic microsomal amidopyrine demethylase activity on halothane hepatotoxicity in the horse.
The hepatotoxic effect of oral halothane in the horse is increased by pretreatment with phenobarbitone or DDT but not by chlorpromazine. Phenobarbitone and DDT increase the activity of hepatic amidopyrine N-demethylase but chlorpromazine does not. Carbon disulphide protects the liver of the horse against halothane.
D000633:Aminopyrine N-Demethylase / Q000037:antagonists & inhibitors / Q000378:metabolism*; D000818:Animals; D002246:Carbon Disulfide / Q000494:pharmacology; D056486:Chemical and Drug Induced Liver Injury; D002746:Chlorpromazine / Q000494:pharmacology; D003634:DDT / Q000494:pharmacology; D006221:Halothane / Q000633:toxicity*; D006736:Horses / Q000378:metabolism*; D008099:Liver / Q000187:drug effects* / Q000201:enzymology; D008862:Microsomes, Liver / Q000201:enzymology*; D009336:Necrosis; D010634:Phenobarbital / Q000494:pharmacology
D003634:DDT; D000633:Aminopyrine N-Demethylase; C019666:amidopyrine N-demethylase; D002246:Carbon Disulfide; D002746:Chlorpromazine; D006221:Halothane; D010634:Phenobarbital