Prevention of thiopental and thiopental/halothane cardiac sensitization to epinephrine in the sheep.
The effects of epinephrine (5 microgram/kg of body weight) on ten unanesthetized sheep were experimentally tested: all sheep displayed serious arrhythmias. Sheep anesthetized with thiopental and thiopental/halothane combination displayed cardiac arrhythmias of the order of 10% and 20% respectively. Challenge injections of epinephrine (5 microgram/kg of body weight) to ten sheep anesthetized with thiopental, and to the same number of animals after 45 minutes of anesthesia with thiopental/halothane, produced serious arrhythmias. However, following preanesthetic treatment with acepromazine maleate (0.5 mg/kg) to 15 sheep, serious arrhythmias were prevented in all of them when they were given arrhythmic doses of epinephrine.
D000075:Acepromazine / Q000494:pharmacology; D000758:Anesthesia / Q000009:adverse effects*; D000818:Animals; D001145:Arrhythmias, Cardiac / Q000139:chemically induced; D004357:Drug Synergism; D004837:Epinephrine / Q000009:adverse effects* / Q000037:antagonists & inhibitors; D005260:Female; D006221:Halothane; D006321:Heart / Q000187:drug effects*; D008297:Male; D011229:Preanesthetic Medication; D012756:Sheep; D013874:Thiopental
D000075:Acepromazine; D013874:Thiopental; D006221:Halothane; D004837:Epinephrine