[Comparison of vaginal cytologic effects and blood elimination curves of different oestrogen drugs (author's transl)].
With different oral oestrogens it was studied, if relations are existing between pharmacokinetic and vaginal effect. By means of Karyopycnotic Index and Dynamic Oestrogenicity Index the cytological effect was quantified from a single dose of oestradiol valerianate, mestranol, ethinyloestradiol and 3 depot oestrogens proved on postmenopause women and compared with adequate pharmacocinetical investigations. The courses of oestrogen levels did not correlate with indices. Both methods of investigation do not compensate, but complete one another. Depotoestrogens and short acting oestrogens are distinguishable with regard to proliferation maxium and steepness of index decline.
D003692:Delayed-Action Preparations / Q000378:metabolism; D004958:Estradiol / Q000097:blood; D004967:Estrogens / Q000097:blood* / Q000494:pharmacology; D004997:Ethinyl Estradiol / Q000097:blood; D005260:Female; D006801:Humans; D007700:Kinetics; D008593:Menopause; D008656:Mestranol / Q000097:blood; D008875:Middle Aged; D012044:Regression Analysis; D014621:Vagina / Q000166:cytology / Q000187:drug effects / Q000378:metabolism*
D003692:Delayed-Action Preparations; D004967:Estrogens; D004997:Ethinyl Estradiol; D004958:Estradiol; D008656:Mestranol
Vergleichende Betrachtung von vaginalzytologischen Indexverläufen und Bluteliminationskurven bei verschiedenen Ostrogenen.