Variants of the HR strain of Sindbis virus lethal for mice.
We have selected two similar variants of Sindbis HR virus which are lethal for mice. Consecutive brain to brain passage series were conducted in suckling and weanling mice. Specific anti-Sindbis HR neutralization tests and protection tests demonstrate that these viruses are derived from the parent Sindbis HR.
D000818:Animals; D000956:Antigens, Viral / Q000032:analysis; D002642:Chick Embryo; D046508:Culture Techniques; D014644:Genetic Variation; D007114:Immunization; D051379:Mice; D012845:Sindbis Virus / Q000254:growth & development / Q000276:immunology / Q000472:pathogenicity*; D014774:Virulence; D014779:Virus Replication
D000956:Antigens, Viral