title: Immunogenetic factors in aetiology of pre-eclampsia/eclampsia (gestosis).
abstract: The evidence that genetic and immunogenetic influences operate in the causation of pre-eclampsia/eclampsia (gestosis) is reviewed. The problems of definitive diagnosis are discussed along with the possibility of a multifactorial aetiology. The difficulties of differentiating trigger and effector mechanisms are also considered. It is concluded that there is evidence for a predisposition, probably genetic, operating in some cases, an immunogenetic mechanism in others, and chromosomal factors in a small group.
mesh_terms: D000782:Aneuploidy; D004461:Eclampsia / Q000209:etiology* / Q000235:genetics / Q000276:immunology; D005260:Female; D006680:HLA Antigens; D006801:Humans; D007125:Immunogenetics; D011225:Pre-Eclampsia / Q000209:etiology* / Q000235:genetics / Q000276:immunology; D011247:Pregnancy; D012744:Sex Ratio; D014427:Twins
chemical_list: D006680:HLA Antigens