Prolonged survival of hypertransfused NZB/NZW mice.
(NZB X NZW)F1 hybrid female mice were transfused fortnightly with 1 ml of packed buffy-coat-poor syngeneic erythrocytes, beginning at 3--4 months of age, in an effort to suppress erythropoiesis selectively and perhaps limit availabiliity of DNA for immune complex formation. The mean increase in survival was about 8 weeks (P less than 0-05). Repeatedly phlebotomized donor female mice tended to sicken earlier and die at younger ages. This is initial support for the hypothesis that erythroblast DNA may be involved in this SLE-like disease.
D000818:Animals; D000936:Antigen-Antibody Complex; D001803:Blood Transfusion; D004920:Erythropoiesis; D005260:Female; D007668:Kidney / Q000473:pathology; D008136:Longevity; D008180:Lupus Erythematosus, Systemic / Q000235:genetics / Q000628:therapy; D051379:Mice; D008814:Mice, Inbred NZB; D008815:Mice, Inbred Strains
D000936:Antigen-Antibody Complex