[Insulin secretion and catecholamine content in the blood plasma in initial stages of cardiac insufficiency].
Test for glucose tolerance was performed in 28 patients with ischemic heart disease and stage IIA circulatory insufficiency and repeated in 17 of them after treatment with cardiac glycosides. The blood collected on an empty stomach, 60 and 120 min after oral administration of 50 g of glucose was tested for the sugar content and the plasma for the content of immunoreactive insulin. In some of these patients the plasma of blood collected on an empty stomach was tested for the contents of noradrenaline and adrenaline. No statistically reliable difference was revealed in the plasma immunoreactive insulin level in patients with ischemic heart disease and stage IIA circulatory insufficiency before and after treatment and also as compared to that in patients with ischemic heart disease but no clinical signs of circulatory insufficiency. In patients with circulatory insufficiency the content of noradrenaline and adrenaline in blood plasma was higher before treatment than after it, but the difference was statistically reliable only in the case of noradrenaline. The degree of intensification of the activity of the sympathicoadrenal system in patients with ischemic heart disease and initial stages of circulatory insufficiency is evidently not sufficient for inhibiting insulin secretion.
D000328:Adult; D000368:Aged; D001775:Blood Circulation; D002395:Catecholamines / Q000097:blood*; D003327:Coronary Disease / Q000503:physiopathology*; D005260:Female; D006801:Humans; D007328:Insulin / Q000378:metabolism*; D000078790:Insulin Secretion; D008297:Male; D008875:Middle Aged; D013997:Time Factors
D002395:Catecholamines; D007328:Insulin
Sekretsiia insulina i soderzhanie katekholaminov v plazme krovi pri nachal'nykh stadiiakh serdechnoĭ nedostatochnosti.