The effect of verapamil on intestinal calcium transport.
Verapamil (1.5 mM) completely inhibits active calcium transport by everted rat duodenum sacs and depresses oxygen consumption by duodenal rings. Increasing the Ca2+ concentration in the incubation medium from 0.4 mM 5.0 mM reverses the inhibition of oxygen consumption by verapamil but is without effect on the extent of inhibition of calcium active transport.
D000818:Animals; D001693:Biological Transport, Active / Q000187:drug effects; D002118:Calcium / Q000378:metabolism*; D004386:Duodenum / Q000187:drug effects / Q000378:metabolism*; D066298:In Vitro Techniques; D010101:Oxygen Consumption / Q000187:drug effects; D051381:Rats; D014700:Verapamil / Q000494:pharmacology*
D014700:Verapamil; D002118:Calcium