A combined use of triphenyl phosphite and 2,2'-dipyridyl diselenide as a coupling reagent in oligonucleotide synthesis.
Oligonucleotides and nucleoside phosphoramidates can be synthesized in high yields by a combined use of triphenyl phosphite and 2,2'-dipyridyl diselenide as a coupling reagent.
D015082:2,2'-Dipyridyl / Q000031:analogs & derivatives; D000577:Amides; D055598:Chemical Phenomena; D002621:Chemistry; D008722:Methods; D009705:Nucleosides; D009841:Oligonucleotides / Q000138:chemical synthesis*; D009943:Organophosphorus Compounds; D016566:Organoselenium Compounds; D017905:Phosphites; D011725:Pyridines; D012643:Selenium
D000577:Amides; D009705:Nucleosides; D009841:Oligonucleotides; D009943:Organophosphorus Compounds; D016566:Organoselenium Compounds; D017905:Phosphites; D011725:Pyridines; D015082:2,2'-Dipyridyl; C012945:2,2'-dipyridyl diselenide; C013318:triphenyl phosphite; D012643:Selenium