Transapical left ventricular bypass (TALVB) without an auxiliary ventricle.
A simple transapical left ventricular bypass system employing a roller pump, transapical LV withdrawal catheter, and outflow filter for continuous blood filtration, has been developed and evaluated in unanesthetized sheep for periods beyond 2 wks. The system provides continuous partial LV bypass and is capable of totally maintaining the circulation in the presence of a vasodilator or when total bypass is desired. Blood damage is minimal and blood transfusions have not been required. The transapical withdrawal catheter has been left in the LV apex beyond 4 mos and demonstrates thrombus formation and myocardial histological changes which suggest this catheter should be removed after pumping or long-term anticoagulation provided.
D000818:Animals; D001243:Assisted Circulation / Q000009:adverse effects / Q000295:instrumentation*; D006328:Cardiac Catheterization / Q000009:adverse effects; D006439:Hemodynamics; D006461:Hemolysis; D012756:Sheep; D013997:Time Factors