[Treatment of haemophilia with factor VIII inhibitor by giving isoagglutinin-free factor VIII concentrate (author's transl)].
Two nine-year-old boys with haemophilia A and circulating inhibitor against factor VIII were given large doses of commercial AHG concentrates to control bleeding. But the isoagglutinins in the AHG concentrates caused haemolysis in both patients. When AHF (Immuno) from AB donors - a cryoprecipate without isoagglutinins - was used no further inhibitor activity was detectable, previously observed anaphylactoid reactions no longer occurred and usual doses of AHG were now sufficient to control bleeding.
D002648:Child; D005169:Factor VIII / Q000627:therapeutic use*; D006461:Hemolysis; D006467:Hemophilia A / Q000188:drug therapy* / Q000209:etiology; D006801:Humans; D007518:Isoantibodies / Q000032:analysis; D008297:Male
D007518:Isoantibodies; D005169:Factor VIII
Therapie von Hemmkörperhämophilie mit isoagglutininfreiem Faktor-VIII-Konzentrat