Therapy for disseminated coccidioidomycosis with transfer factor from a related donor.
A 17 year old caucasian woman in whom disseminated coccidioidomycosis developed with culture positive meningitis during her third trimester of pregnancy was treated with amphotericin B and subsequently with transfer factor prepared from her father's peripheral lymphocytes. Clinical response and in vivo and in vitro immunologic data indicated that this transfer factor afforded a significant contribution to her survival whereas previous therapy with transfer factor from an unrelated donor provided only transient immunologic reactivity. This experience suggests that transfer factor prepared from a related donor with positive responses to C. immitis may be more efficacious than that prepared from an unrelated donor.
D000293:Adolescent; D000666:Amphotericin B / Q000627:therapeutic use; D003047:Coccidioidomycosis / Q000188:drug therapy / Q000276:immunology / Q000628:therapy*; D005260:Female; D006801:Humans; D007111:Immunity, Cellular; D008213:Lymphocyte Activation; D010290:Parents; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000276:immunology / Q000628:therapy*; D012075:Remission, Spontaneous; D014165:Transfer Factor / Q000627:therapeutic use*
D014165:Transfer Factor; D000666:Amphotericin B