Comparison of furazolidone and carbadox in the feed for treatment of Salmonella choleraesuis in swine.
Furazolidone and carbadox, as feed additives, were only partially effective for the treatment of experimentally induced infections of Salmonella choleraesuis var kunzendorf in swine. There was little difference in mortality between the medicated exposed and the nonmedicated exposed swine, and medication did not markedly decrease rectal temperature. In experiment I, the mortality in groups fed furazolidone was lower than in those fed carbadox, but higher than in the nonmedicated exposed. In experiment II, there was little difference in mortality between the medicated and the nonmedicated exposed swine. In both experiments, however, exposed swine that survived had body weight gains significantly (P less than 0.05) higher in 3 of the 4 medicated exposed groups than in the nonmedicated groups. With the exception of the swine fed carbadox for 2 weeks, the feed and water consumption of the survivors in the medicated exposed groups during the recovery phase was higher (but not significantly (P greater than 0.05) higher) than that of the nonmedicated exposed groups. The problems with medicating in feed for treatment of S choleraesuis were that the infected swine frequently vomited the feed and became partially anorectic.
D000284:Administration, Oral; D000821:Animal Feed; D000818:Animals; D001835:Body Weight; D002218:Carbadox / Q000008:administration & dosage / Q000627:therapeutic use*; D003967:Diarrhea / Q000188:drug therapy / Q000662:veterinary; D004326:Drinking; D005664:Furazolidone / Q000008:administration & dosage / Q000627:therapeutic use*; D011810:Quinoxalines / Q000627:therapeutic use*; D012481:Salmonella Infections, Animal / Q000188:drug therapy*; D013552:Swine; D013553:Swine Diseases / Q000188:drug therapy*
D011810:Quinoxalines; D005664:Furazolidone; D002218:Carbadox