title: Single mitotic center for rodent cochlear duct.
abstract: The pattern of terminal mitosis in mouse otocyst observed by Ruben led him to postulate the existence of a growth zone at the junction of saccular and cochlear primordia. With the use of colchicine, an antimitotic drug, a localized zone of mitotic activity has been demonstrated at this predicted site.
mesh_terms: D000818:Animals; D003051:Cochlea / Q000196:embryology*; D003078:Colchicine / Q000494:pharmacology; D004423:Ear / Q000196:embryology; D005260:Female; D051379:Mice; D008938:Mitosis / Q000187:drug effects; D011247:Pregnancy
chemical_list: D003078:Colchicine