Plasma and organ counts of 3H in normal or immune mice and sheep injected with 3H-epsilon-dinitrophenyl-lysine.
Mice and sheep with circulating antibody to dinitrophenol (Dnp) retained injected 3H-epsilon-Dnp-lysine in their circulation for three and seven days respectively. In normal mice and sheep the 1 h post injection counts of 3H/g of kidney were higher than those per ml of plasma. In immune mice, plasma 3H counts were always higher than kidney counts, whereas at 1 h in immune sheep, plasma and kidney counts were similar. Liver, spleen and lung counts were also made in some experiments. Increased 3h counts could be demonstrated in mice treated passively with sheep anti-Dnp serum and then given 3h-epsilon-Dnp-lysine. The fast gamma-globulin of sheep antiserum is mainly responsible for retention of hapten in mouse plasma.
D000818:Animals; D000906:Antibodies / Q000032:analysis; D004140:Dinitrophenols / Q000276:immunology*; D005260:Female; D006241:Haptens; D007116:Immunization, Passive; D007668:Kidney / Q000276:immunology; D008099:Liver / Q000276:immunology; D008168:Lung / Q000276:immunology; D008239:Lysine / Q000276:immunology*; D051379:Mice; D012756:Sheep / Q000276:immunology*; D013154:Spleen / Q000276:immunology
D000906:Antibodies; D004140:Dinitrophenols; D006241:Haptens; D008239:Lysine