Anti-drug-related antibodies in nonthrombocytopenic cardiac patients.
Drug-related antibodies (quinidine, hydrochlorothiazide, and digoxin) were studied using the 51Cr platelet lysis test and a recently introduced simplified platelet factor 3 assay in a total of 109 patients admitted to a coronary care unit. Quinidine antibodies were found in 16 (14.7%), hydrochlorothiazide antibodies in six (5.5%) and digoxin antibodies in two (1.8%) of 109 patients. All patients had normal hematologic data, including platelet counts. There was a significantly high incidence of quinidine antibodies in male patients (p less than 0.02), despite the previous report that quinidine-induced purpura was seen predominantly in female patients. Ten patients (9.2%) had antiplatelet antibodies. The simplified platelet factor 3 assay can easily be done in most laboratories and appears as sensitive as the 51Cr platelet lysis test. The high incidence of drug-related or antiplatelet antibodies in hematologically asymptomatic patients may indicate the presence of an insidious, compensated thrombolytic state in many patients.
D000328:Adult; D000368:Aged; D000906:Antibodies; D001792:Blood Platelets / Q000276:immunology; D002860:Chromium Radioisotopes; D004077:Digoxin / Q000276:immunology*; D005260:Female; D006801:Humans; D006852:Hydrochlorothiazide / Q000276:immunology*; D008297:Male; D008875:Middle Aged; D010977:Platelet Factor 3 / Q000378:metabolism; D011696:Purpura, Thrombocytopenic / Q000276:immunology; D011802:Quinidine / Q000276:immunology*
D000906:Antibodies; D002860:Chromium Radioisotopes; D006852:Hydrochlorothiazide; D010977:Platelet Factor 3; D004077:Digoxin; D011802:Quinidine