Estrogenic sensitivity of alpha-receptors in the urethra musculature.
Estrogene has a tonicising effect upon urethra musculature. There is also the same demonstrable influence of alpha-receptor stimulating drugs upon the urethra pressure profile. After preliminary treatment with estrogene, there is a considerably stronger tonicising effect of alpha-stimulating drugs than without such a treatment. So the combination of estrogene and alpha-stimulating drugs seems a useful addition to the conservative treatment of stress incontinence.
D004967:Estrogens / Q000494:pharmacology* / Q000627:therapeutic use; D005260:Female; D006801:Humans; D008297:Male; D009129:Muscle Tonus / Q000187:drug effects; D010656:Phenylephrine / Q000494:pharmacology / Q000627:therapeutic use; D011312:Pressure; D011941:Receptors, Adrenergic / Q000187:drug effects*; D013578:Synephrine / Q000494:pharmacology / Q000627:therapeutic use; D014521:Urethra / Q000187:drug effects* / Q000503:physiopathology; D014550:Urinary Incontinence, Stress / Q000188:drug therapy
D004967:Estrogens; D011941:Receptors, Adrenergic; D010656:Phenylephrine; D013578:Synephrine