Clonal origin of inherited medullary thyroid carcinoma and pheochromocytoma.
A black female with inherited medullary thyroid carcinoma and pheochromocytoma was a mosaic for glucose-6-phosphate dehydrogenase types A and B in normal tissues (blood, thyroid, and adrenal gland); both the medullary carcinoma and pheochromocytoma tissue showed a B pattern only. This finding suggests a single clone origin for each of the tumors. Other inherited tumors similarly studied in man have appeared to be multiclonal in origin.
D000328:Adult; D044383:Black People; D002999:Clone Cells; D005260:Female; D005954:Glucosephosphate Dehydrogenase / Q000378:metabolism; D006801:Humans; D009154:Mutation; D009420:Nervous System / Q000196:embryology; D010375:Pedigree; D010673:Pheochromocytoma / Q000201:enzymology / Q000235:genetics*; D013577:Syndrome; D013964:Thyroid Neoplasms / Q000201:enzymology / Q000235:genetics*
D005954:Glucosephosphate Dehydrogenase