[Experimental coronary stenoses and occlusions].
A constrictor for experimentally inducing stenoses and obstructions of the coronary artery is described. Smallness, good adaptability to every vascular diameter, atraumatic insertion, and slow swelling are its advantages. Within 12 months a coronary artery could be constricted by two thirds. In one third of the cases the lumen was narrowed by more than 75 per cent. Just 50 per cent of the cases showed chronic infarction after coronary obstruction, the other half developed differently marked myocardiac fibrosis. At high-degree narrowing of the arteries, 75 per cent of the cases showed disseminated myocardiac fibrosis. The occlusion of the vessel is caused by constrictor, by fibroplastic alteration of the vascular wall, and by thrombosis. Different degrees of myocardiac ischemia are sequelae of different development of collaterals. The constrictor may be used for studies on the development of collaterals as well as on therapeutic measures in chronic ischemia of the myocardium.
D000818:Animals; D002364:Caseins; D003097:Collateral Circulation; D003326:Coronary Circulation; D003327:Coronary Disease / Q000209:etiology* / Q000503:physiopathology; D004195:Disease Models, Animal; D004285:Dogs; D005260:Female; D008297:Male; D009203:Myocardial Infarction / Q000209:etiology; D010969:Plastics
D002364:Caseins; D010969:Plastics
Experimentelle Erzeugung von Koronargefässstenosen und -verschlüssen.