Modification of brain deoxyribonucleic acid base content with maturation in normal and malnourished rats.
The mol percentage of 5-hydroxymethylcytosine is 2.2 times greater in the adult than in 2-day-old rat brain DNA. The concentration of 5-hydroxymethylcytosine falls in corresponding liver DNA preparations. This normal increase in brain 5-hydroxymethylcytosine is abolished in rats placed on an 8%-protein diet 5 days after birth.
D000367:Age Factors; D000818:Animals; D000831:Animals, Newborn; D001483:Base Sequence; D001921:Brain / Q000254:growth & development / Q000378:metabolism*; D003596:Cytosine / Q000032:analysis; D004247:DNA / Q000378:metabolism*; D005260:Female; D008099:Liver / Q000032:analysis; D008297:Male; D009748:Nutrition Disorders / Q000378:metabolism*; D011488:Protein Deficiency / Q000378:metabolism; D051381:Rats
D003596:Cytosine; D004247:DNA