[Effect of sarcolysin and asalin on the incorporation of thymidine-H3 in the DNA of sarcoma 45 and tissues of tumor-bearing rats].
A comparison was made of the action of sarcolysin and asalin on the synthesis of DNA in sarcoma 45, the spleen, thymus, bone marrow and liver of tumour-bearing rats depending of the time of administration of the preparation. There was seen a direct relationship between the selectivity of sarcolysin and asalin action with a different bearer structure and the capacity of these perparations to depress DNA synthesis in the tumour and in normal tissues.
D000818:Animals; D001853:Bone Marrow / Q000187:drug effects / Q000378:metabolism; D004247:DNA / Q000096:biosynthesis*; D004273:DNA, Neoplasm / Q000096:biosynthesis*; D008099:Liver / Q000187:drug effects / Q000378:metabolism; D008297:Male; D008558:Melphalan / Q000031:analogs & derivatives* / Q000494:pharmacology*; D051381:Rats; D012513:Sarcoma, Experimental / Q000378:metabolism*; D013154:Spleen / Q000187:drug effects / Q000378:metabolism; D013936:Thymidine / Q000378:metabolism; D013950:Thymus Gland / Q000187:drug effects / Q000378:metabolism; D013997:Time Factors
D004273:DNA, Neoplasm; D004247:DNA; D008558:Melphalan; D013936:Thymidine
Deĭstivie sarkolizina i asalina na vkliuchenie timidina-H3 v DNK sarkomy 45 i tkaneĭ krys-opukholenositeleĭ