title: Reduction by coenzyme Q10 of the acute toxicity of adriamycin in mice.
abstract: Pretreatment for four days with coenzyme Q10 (COQ10) reduced the acute toxicity in mice treated with adriamycin. In two sequential protocols, adriamycin allowed only 36 and 42% survival, respectively. Pretreatment with COQ10 allowed 80 and 86% survival, respectively. The differences are significant, p less than 0.05. The mechanism for this reduction in the acute toxicity may be based upon the prevention by the supplementary COQ10 of the inhibition caused by adriamycin to COQ10-dependent enzymes in cardiac and and other tissues. The prospect of diminishing the toxicity of adriamycin in cancer patients remains promising and important.
mesh_terms: D000818:Animals; D004317:Doxorubicin / Q000037:antagonists & inhibitors* / Q000633:toxicity; D008297:Male; D051379:Mice; D013997:Time Factors; D014451:Ubiquinone / Q000494:pharmacology*
chemical_list: D014451:Ubiquinone; D004317:Doxorubicin