Arthritis Rounds: Ascites as the major manifestation of systemic lupus erythematosus.
It is uncommon for ascites secondary to severe peritoneal inflammation to be the major manifestation of systemic lupus erythematosus. Chronic nonspecific inflammation with a granular type immunofluorescent staining along the mesothelial layer of the peritoneum and peritoneal blood vessels was demonstrated in peritoneal tissue obtained at laparotomy. Paramyxovirus-like structures were seen within vascular endothelium. The ascites diminished with high-dose prednisone and cyclophosphamide therapy.
D000328:Adult; D001201:Ascites / Q000209:etiology* / Q000473:pathology; D001379:Azathioprine / Q000627:therapeutic use; D003520:Cyclophosphamide / Q000627:therapeutic use; D004351:Drug Resistance; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000150:complications* / Q000473:pathology; D010532:Peritoneal Diseases / Q000150:complications / Q000209:etiology / Q000473:pathology; D011241:Prednisone / Q000627:therapeutic use; D012700:Serositis / Q000150:complications / Q000209:etiology / Q000473:pathology
D003520:Cyclophosphamide; D001379:Azathioprine; D011241:Prednisone