Protection of rats against nippostrongylus brasiliensis with worm antigens by oral administration.
Different types of antigens collected from adult Nippostrongylus brasiliensis were used to vaccinate rats against this parasite: somatic worm homogenate, secretory antigens and whole fixed worms. After challenge infection there was a significant reduction of worm number in immunized rats. However, vaccination with secretory antigens only induced a high level of immunity, indicating that protective antigens were probably worm metabolites.
D000284:Administration, Oral; D000723:Ancylostomatoidea / Q000276:immunology*; D000818:Animals; D000941:Antigens; D005260:Female; D006725:Hookworm Infections / Q000517:prevention & control*; D007814:Larva; D009559:Nippostrongylus / Q000276:immunology*; D051381:Rats; D014611:Vaccination; D014612:Vaccines / Q000008:administration & dosage
D000941:Antigens; D014612:Vaccines