Hemoglobin synthesis in somatic cell hybrids: independent segregation of the human alpha- and beta-globin genes.
Hybrid somatic cells containing a partial complement of human chromosomes were used to demonstrate that the human alpha- and beta-globin genes are located on different chromosomes. Two cell lines consisting of a cross of mouse with human fibroblasts contained the human alpha- and not the beta-globin gene, while a cross of human marrow cells with mouse erythroleukemia cells expressed the human beta- but not the alpha-globin gene.
D000818:Animals; D002874:Chromosome Mapping; D002875:Chromosomes / Q000378:metabolism*; D005796:Genes; D006454:Hemoglobins / Q000096:biosynthesis*; D006822:Hybrid Cells / Q000378:metabolism; D051379:Mice; D009693:Nucleic Acid Hybridization
D006454:Hemoglobins