Smooth muscle cell response to endothelial injury.
Electron microscopy and autoradiography with 3H-thymidine have been employed to study the cellular dynamic of intimal thickening occurring in the rabbit carotid artery after selective endothelial injury. The results obtained suggest that migration of SMC of the tunica media rather than proliferation is the key event in the development of the intimal thickening.
D000818:Animals; D001158:Arteries / Q000293:injuries* / Q000473:pathology; D002455:Cell Division; D004727:Endothelium / Q000473:pathology; D005260:Female; D008297:Male; D008854:Microscopy, Electron; D009130:Muscle, Smooth / Q000473:pathology; D011817:Rabbits