[Immunodepressive activity of phenobarbital chemically bound to the protein carrier].
Experiments conducted on mice immunized with sheep's erythrocytes proved that phenobarbital, even in toxic doses does not produce any immunodepressive effect. But when it is covalently bound by the diazo-method with a protein-carrier phenobarbital becomes a strong immunodepressant. Then, however, it does not affect the central nervous system, nor influence the immunodepressive activity of cyclophosphamide--an agent metabolically activated in the liver. Free phenobarbital mitigates the effect of cyclophosphamide on the immunological response in mice.
D000818:Animals; D000917:Antibody Formation / Q000187:drug effects; D000921:Antibody-Producing Cells / Q000187:drug effects; D002352:Carrier Proteins / Q000276:immunology*; D003520:Cyclophosphamide / Q000276:immunology; D004305:Dose-Response Relationship, Drug; D004347:Drug Interactions; D007166:Immunosuppressive Agents / Q000276:immunology*; D008297:Male; D051379:Mice; D008805:Mice, Inbred A; D008807:Mice, Inbred BALB C; D008810:Mice, Inbred C57BL; D010634:Phenobarbital / Q000138:chemical synthesis / Q000276:immunology*; D011485:Protein Binding; D013329:Structure-Activity Relationship
D002352:Carrier Proteins; D007166:Immunosuppressive Agents; D003520:Cyclophosphamide; D010634:Phenobarbital
Immunodepressivnaia aktivnost' fenobarbitala, khimicheski sviazannogo s belkom-nositelem