Hepatic functional deterioration after portacaval shunt in the rat. Effects on sulfobromophthalein transport-maximum, indocyanine green clearance and galactose elimination capacity.
The consequences of a portacaval shunt on liver function were studied in male Sprague-Dawley rats. Fourteen days after an end-to-side portacaval anastomosis the galactose elimination capacity and the plasma clearance of indocyanine green were reduced in proportion to the approximately 50% loss in liver mass. The biliary transport maximum for sulfobromophthalein, on the other hand, decreased by almost 70% from 153 to 52 nmoles per min per min per 100 g after portacaval anastomosis. This reduction of sulfobromophthalein excretion was accompained by a significant decrease in the hepatic conjugation of the dye to glutathione. Our findings demonstrate that a quantitative and qualitative functional deterioration of previously normal livers results from portal blood deprivation.
D000818:Animals; D001646:Bile / Q000378:metabolism; D001692:Biological Transport; D001794:Blood Pressure; D001835:Body Weight; D005690:Galactose / Q000378:metabolism*; D007208:Indocyanine Green / Q000378:metabolism*; D008099:Liver / Q000378:metabolism*; D008111:Liver Function Tests; D008297:Male; D008657:Metabolic Clearance Rate; D009929:Organ Size; D011167:Portacaval Shunt, Surgical / Q000009:adverse effects*; D011183:Postoperative Complications / Q000378:metabolism*; D051381:Rats; D013448:Sulfobromophthalein / Q000378:metabolism*
D013448:Sulfobromophthalein; D007208:Indocyanine Green; D005690:Galactose