Post-mortem survival of hippuric acid formation in rat and human cadaver tissue samples.
1. A rapid and sensitive semi-micro method for the determination of hippuric acid formation by tissue samples in vitro is described and applied to the determination of the post-mortem survival of hippuric acid formation in rat and human cadaver tissue samples. 2. Hippuric acid formation survived in rat and human cadaver liver for at least 72 h when corpses were stored at 4 degrees. 3. Hippuric acid formation was detected in human cadaver liver and kidney samples and was absent from brain, intestine, heart and lung. 4. Post-mortem liver samples from a case of acute pancreatitis failed to form hippuric acid as did kidney samples from a case of systemic lupus erythematosus with renal involvement.
D000328:Adult; D000368:Aged; D000818:Animals; D001921:Brain / Q000378:metabolism; D005260:Female; D006626:Hippurates / Q000378:metabolism*; D006801:Humans; D007231:Infant, Newborn; D007234:Infant, Premature; D007421:Intestine, Small / Q000378:metabolism; D007668:Kidney / Q000378:metabolism; D008099:Liver / Q000378:metabolism; D008168:Lung / Q000378:metabolism; D008875:Middle Aged; D009928:Organ Specificity; D010195:Pancreatitis / Q000378:metabolism; D011180:Postmortem Changes; D011247:Pregnancy; D051381:Rats; D013045:Species Specificity
D006626:Hippurates