Specificity of the digoxin radioimmunoassay with respect to dihydrodigoxin.
An investigation was conducted to determine the specificity of the digoxin antibody provided in a commercially available radioimmunoassay kit with respect to dihydrodigoxin. Over the concentration range of 0.5 to 8.0 ng./ml. dihydrodigoxin displaced the 125I digoxin derivative from the antibody to a degree that could be significant at clinically observed serum and urine digoxin concentrations.
D000918:Antibody Specificity; D003429:Cross Reactions; D004077:Digoxin / Q000031:analogs & derivatives / Q000032:analysis*; D006801:Humans; D007457:Iodine Radioisotopes; D011863:Radioimmunoassay
D007457:Iodine Radioisotopes; D004077:Digoxin