CC14 administration to strain A/J mice or rats and the arachidonic acid content of their liver microsomal prospholipids.
CC14 administration of Sprague-Dawley male rats causes a significant decrease in the arachidonic acid content of their liver microsomal phospholipids. On the contrary, its administration to strain A/J male mice does not modify the concentration during periods of intoxication up to 24 hr. Since this strain of mice is more susceptible to CC14-induced injury than the rat, results indicate that lipid peroxidation can not be the key event in damage induced by this haloalkane.
D000818:Animals; D001095:Arachidonic Acids / Q000378:metabolism*; D002252:Carbon Tetrachloride Poisoning / Q000378:metabolism*; D005227:Fatty Acids / Q000378:metabolism; D008297:Male; D051379:Mice; D008805:Mice, Inbred A; D008862:Microsomes, Liver / Q000378:metabolism*; D010743:Phospholipids / Q000378:metabolism*; D051381:Rats; D013997:Time Factors
D001095:Arachidonic Acids; D005227:Fatty Acids; D010743:Phospholipids