Azoxymethane-induced liver hemangiosarcomas in inbred strain-2 guinea pigs.
Intrarectal administration of 0.5 ml of a 0.2% solution of azoxymethane twice weekly for 33 weeks to female inbred strain-2 guinea pigs specifically induced multiple liver hemangiosarcomas in 15 of 16 animals 32-54 weeks after the first treatment. No neoplasms and preneoplastic changes were found in the large intestine.
D000818:Animals; D001391:Azo Compounds / Q000633:toxicity*; D001397:Azoxymethane / Q000633:toxicity*; D006168:Guinea Pigs; D006394:Hemangiosarcoma / Q000139:chemically induced*; D007267:Injections; D008113:Liver Neoplasms / Q000139:chemically induced*; D009374:Neoplasms, Experimental / Q000139:chemically induced; D012007:Rectum
D001391:Azo Compounds; D001397:Azoxymethane