title: The pathology of americium 241.
abstract: Male CBA-mice were injected intraperitoneally with different doses of 241Am-citrate (16, 8, 0.4, 0.2, 0.04 muCi/kg). The two highest doses were highly destructive of the haematopoietic tissues, testes and bone tissue. The highest frequency of induced tumours of the skeleton and haematopoietic tissue was found in the 8 muCi group. In the liver, adrenal glands, kidney and heart degenerative lesions were found mainly in the higher dose groups. In the lower dose groups degenerative lesions seemed to appear earlier and at a higher frequency than in the control group.
mesh_terms: D000311:Adrenal Glands / Q000528:radiation effects; D000576:Americium; D000818:Animals; D001853:Bone Marrow / Q000528:radiation effects; D001859:Bone Neoplasms / Q000209:etiology / Q000473:pathology; D001842:Bone and Bones / Q000528:radiation effects; D006321:Heart / Q000528:radiation effects; D007668:Kidney / Q000528:radiation effects; D008099:Liver / Q000528:radiation effects; D008113:Liver Neoplasms / Q000209:etiology / Q000473:pathology; D008175:Lung Neoplasms / Q000209:etiology / Q000473:pathology; D008228:Lymphoma, Non-Hodgkin / Q000209:etiology / Q000473:pathology; D008297:Male; D051379:Mice; D008808:Mice, Inbred CBA; D009374:Neoplasms, Experimental; D009381:Neoplasms, Radiation-Induced; D013737:Testis / Q000528:radiation effects
chemical_list: D000576:Americium