Kallikrein and renal enzyme excretion in rats.
Using the model of renal enzyme excretion in rats it was investigated whether a chemically defined kininogenase (kallikrein) exerts shock-inducing activity. Following i.p. injections of kallikrein in doses of 1000 or 7000 KU/kg body weight, an increase in urinary AP- and LAP-activities was encountered as well as an increase in creatinine excretion. These effects were attributable to increased diuresis and could not be related to any anaphylactoid activity (elicitation of vascular shock) of the injected enzyme preparation. According to these experimental results, kallikrein may not be considered as anaphylactoid drug, at least not in the rat.
D000469:Alkaline Phosphatase / Q000652:urine; D000707:Anaphylaxis / Q000139:chemically induced* / Q000652:urine; D000818:Animals; D003404:Creatinine / Q000652:urine; D007610:Kallikreins / Q000494:pharmacology*; D007668:Kidney / Q000187:drug effects / Q000201:enzymology*; D007931:Leucyl Aminopeptidase / Q000652:urine; D008297:Male; D051381:Rats
D003404:Creatinine; D000469:Alkaline Phosphatase; D007931:Leucyl Aminopeptidase; D007610:Kallikreins