Clostridium perfringens infection complicating chemotherapy for choriocarcinoma.
A case of Clostridium perfringens sepsis and gas gangrene complicating chemotherapy for gestational choriocarcinoma is reported. The infection was eradicated using antibiotics, surgery, and hyperbaric oxygen therapy. The pathophysiology, diagnosis, and treatment of this unusual but often lethal complication are reviewed.
D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D002822:Choriocarcinoma / Q000150:complications* / Q000188:drug therapy; D003520:Cyclophosphamide / Q000627:therapeutic use; D003609:Dactinomycin / Q000627:therapeutic use; D004359:Drug Therapy, Combination; D005260:Female; D005738:Gas Gangrene / Q000150:complications* / Q000628:therapy; D006801:Humans; D006931:Hyperbaric Oxygenation; D008727:Methotrexate / Q000627:therapeutic use; D011247:Pregnancy
D000900:Anti-Bacterial Agents; D003609:Dactinomycin; D003520:Cyclophosphamide; D008727:Methotrexate