The effect of isosorbide dinitrate following experimental coronary occlusion.
The results of the present investigation indicate that ISDN infusion following experimental coronary occlusion in anesthetized dogs (1) lowers systemic, cardiac, and pulmonary blood pressures; (2) decreases systemic resistance; (3) has no significant effect on cardiac output, heart rate, and stroke volume; (4) decreases serum CPK levels; and (5) has little effect on blood biochemical parameters. These results suggest that ISDN may have a minimal effect on the ischemic heart by means of a slight decrease in peripheral vascular resistance and systemic blood pressure.
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D002302:Cardiac Output / Q000187:drug effects; D003327:Coronary Disease / Q000097:blood / Q000188:drug therapy* / Q000209:etiology / Q000401:mortality; D003402:Creatine Kinase / Q000097:blood; D004195:Disease Models, Animal; D004285:Dogs; D004353:Drug Evaluation, Preclinical; D007548:Isosorbide Dinitrate / Q000627:therapeutic use*; D008297:Male; D014655:Vascular Resistance / Q000187:drug effects
D003402:Creatine Kinase; D007548:Isosorbide Dinitrate