title: A specific receptor for retinol binding protein as detected by the binding of human and bovine retinol binding protein to pigment epithelial cells.
abstract: By means of autoradiographic techniques the specific plasma carrier of retinol, namely retinol binding protein (RBP) in a radioactive form (retinol-125I.RBP), bound specifically in vivo to the choroidal surface of intact, isolated bovine pigment epithelial cells. The retinol-125I.RBP did not bind to the retinal surface of the pigment epithelial cells nor did not bind to photoreceptors. Retinol is normally provided to the retina from the blood via a specific complex formation with a receptor on the chordial surface of the pigment epithelial cells. Retinol metabolism might be deranged in some diseases through a defect in the pigment epithelial receptor for RBP.
mesh_terms: D000818:Animals; D001345:Autoradiography; D002417:Cattle; D006801:Humans; D010857:Pigment Epithelium of Eye / Q000166:cytology* / Q000378:metabolism; D011955:Receptors, Drug; D012177:Retinol-Binding Proteins / Q000378:metabolism; D054839:Retinol-Binding Proteins, Plasma
chemical_list: D011955:Receptors, Drug; D012177:Retinol-Binding Proteins; D054839:Retinol-Binding Proteins, Plasma