Method of constructing a dose-response curve for normal cells in situ.
A method is presented for planning experiments and analysing data with a view to determining in detail the shape of a single-dose survival curve for normal cells exposed in situ to relatively low doses of radiation. Applying this method to data published on the responses of gastric mucosal and colonic stem cells showed that the single-dose survival curves for these cells were linear up to about 250 rads, after which they bent downwards. Some applications of this method are discussed.
D000818:Animals; D002470:Cell Survival / Q000528:radiation effects; D003106:Colon / Q000528:radiation effects*; D004307:Dose-Response Relationship, Radiation; D004848:Epithelium / Q000528:radiation effects; D005753:Gastric Mucosa / Q000528:radiation effects*; D008722:Methods; D051379:Mice; D011830:Radiation Effects