Effects of diuretics on thyroid function of guinea pigs.
Uptake of radioiodide by the isolated thyroid and serum concentrations of thyroxine (T4) and tri-iodothyronine (T3) were determined in guinea pigs pretreated with ethacrynic acid (20 mg/kg), furosemide (40 mg/kg) or hydrochlorothiazide (40 mg/kg). It was found that both ethacrynic acid and furosemide suppressed the 131I uptake by the isolated thyroid tissues. In addition, thyroid weight and serum T3 concentration were lower in ethacrynic acid-treated animals. It seems that some diuretics, particularly ethacrynic acid, depressed the function of thyroidal follicular cells.
D000818:Animals; D004232:Diuretics / Q000494:pharmacology*; D006168:Guinea Pigs; D007457:Iodine Radioisotopes; D008297:Male; D013960:Thyroid Function Tests; D013961:Thyroid Gland / Q000187:drug effects*; D013974:Thyroxine / Q000097:blood; D014284:Triiodothyronine / Q000097:blood
D004232:Diuretics; D007457:Iodine Radioisotopes; D014284:Triiodothyronine; D013974:Thyroxine