Effects of dextran 40 on the proximal renal tubule. Studies on transfer maxima of glucose and hippuran in the rat.
The effect of a single large dose of dextran 40 on transfer maxima for glucose and hippuran was studied in the rat. A close relationship between these transfer maxima and the glomerular filtration rate and/or transport of water and electrolytes was demonstrated. Despite the presence of dextran 40-induced "osmotic nephrosis" the observed parameters, expressed as mg/ml glomerular filtrate, were unchanged.
D000818:Animals; D001692:Biological Transport / Q000187:drug effects; D001834:Body Water / Q000378:metabolism; D003911:Dextrans / Q000008:administration & dosage / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D005919:Glomerular Filtration Rate / Q000187:drug effects; D005947:Glucose / Q000378:metabolism*; D007465:Iodohippuric Acid / Q000378:metabolism*; D007687:Kidney Tubules, Proximal / Q000187:drug effects* / Q000378:metabolism; D008297:Male; D051381:Rats
D003911:Dextrans; D007465:Iodohippuric Acid; D005947:Glucose