title: Sudden death in the laboratory rat.
abstract: Vulnerability to sudden death was produced in laboratory rats by manipulating their developmental history. Rats who were reared in isolation died suddenly when placed in a stressful swimming situation. Handling of these singly-housed rats from 25 to 100 days of age potentiated the phenomenon. However, animals who were group housed did not die even when they had been previously handled.
mesh_terms: D000818:Animals; D003423:Critical Period, Psychological; D006234:Handling, Psychological; D006801:Humans; D008297:Male; D051381:Rats; D012934:Social Isolation; D013315:Stress, Psychological; D013550:Swimming