Anthelmintic efficacy of mebendazole for pinworm infection of mice.
A series of 6 experiments was conducted to test the efficacy of mebendazole in eliminating naturally occurring pinworm infections from mice. Subjects treated with from 40-500 mg/kg of the drug harbored markedly fewer parasites than untreated controls. Treatment at 10 mg/kg appeared to be less effective. No mortality or overt signs of toxicity were observed in any of the experimental subjects.
D000818:Animals; D001562:Benzimidazoles / Q000627:therapeutic use*; D008463:Mebendazole / Q000627:therapeutic use*; D051379:Mice; D009349:Nematode Infections / Q000188:drug therapy / Q000662:veterinary*; D010123:Oxyuriasis / Q000188:drug therapy / Q000662:veterinary; D010124:Oxyuroidea; D012376:Rodent Diseases / Q000188:drug therapy*
D001562:Benzimidazoles; D008463:Mebendazole