Red cell organic phosphates during administration of salicylates.
The effect of salicylates on erythrocyte 2,3-diphosphoglycerate (2,3-DPG) and adenosine triphosphate (ATP) was studied in vivo in 3 groups of healthy subjects receiving acetylsalicyclic acid (18 persons), sodium salicylate (5 persons) and salicylamide (7 persons) in therapeutic dosage. No effect was found on 2,3-DPG in any of the 3 groups. ATP was significantly decreased (p less than 0.05) when acetylsalicylic acid or sodium salicylate was given.
D000255:Adenosine Triphosphate / Q000097:blood*; D000293:Adolescent; D000328:Adult; D000636:Aminosalicylic Acids / Q000494:pharmacology; D001241:Aspirin / Q000494:pharmacology; D004163:Diphosphoglyceric Acids / Q000097:blood*; D004912:Erythrocytes / Q000378:metabolism*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D012459:Salicylates / Q000494:pharmacology*; D012980:Sodium Salicylate / Q000494:pharmacology
D000636:Aminosalicylic Acids; D004163:Diphosphoglyceric Acids; D012459:Salicylates; D000255:Adenosine Triphosphate; D001241:Aspirin; D012980:Sodium Salicylate