title: [Nicotine metabolism in the pig (author's transl)].
abstract: After i.v. injection of 0.33 mg nicotine/kg the elimination of unchanged nicotine as well as nicotine-N-oxide, cotinine, nornicotine and norcotinine was determined in the urine of pigs dependent on time. In female pigs 16.3% and in male pigs 25.9% of the applied nicotine were recovered in form of the mentioned compounds within 31h. Nicotine elimination essentially stopped in the collecting period 3-8 h. The main decomposition products nicotine-N-oxide and cotinine were eliminated to a significant extent also 8-23 h after application.
mesh_terms: D000818:Animals; D003367:Cotinine / Q000652:urine; D005260:Female; D008297:Male; D009538:Nicotine / Q000031:analogs & derivatives / Q000378:metabolism* / Q000652:urine; D012737:Sex Factors; D013552:Swine; D013997:Time Factors
chemical_list: D009538:Nicotine; D003367:Cotinine
vernacular_title: Uber den Nikotinstoffwechsel beim Schwein