Radioimmunoassay of human beta-lipotropin in unextracted plasma.
A sensitive and specific radioimmunoassay for human beta-lipotropin (betah-LPH) in unextracted plasma was developed using pur betah-LPH as tracer and standard and an antiserum not cross-reacting with human beta-MSH and hACTH. In healthy volunteers plasma betah-LPH ranged from less than 20 to 150 pg/ml at 8:00 a.m. and rose after metyrapone administration. betah-LPH was very low in panhypopituitarism, normal in most patients with untreated Cushing's disease, elevated in acromegaly and extremely high in Nelson's syndrome.
D000172:Acromegaly / Q000097:blood; D003480:Cushing Syndrome / Q000097:blood; D005260:Female; D006801:Humans; D007018:Hypopituitarism / Q000097:blood; D007106:Immune Sera; D008297:Male; D008797:Metyrapone / Q000008:administration & dosage; D009347:Nelson Syndrome / Q000097:blood; D011863:Radioimmunoassay; D008083:beta-Lipotropin / Q000097:blood*
D007106:Immune Sera; D008083:beta-Lipotropin; D008797:Metyrapone