title: The role of movement in the development of a digital flexor tendon.
abstract: D-tubocurarine was injected into the air sac of 8-day chick embryos to prevent movement of the digits of the hind limb. The embryos were paralyzed from the tenth to the eighteenth day, when the experiment was terminated. The immobilization of the flexor digitorum profundus tendons in the tarsus resulted in a loss of specialized structures around and on this tendon, as determined by light and electron microscopy. Specialized areas observed in the normal chick (synovial cavity, fibrocartilaginous area, and elastic vinculum) failed to form, as a result of the paralysis of the digit. Several authors have shown previously that movement is a requirement for the molding and maintenance of joint cavities in vivo, in ovo and in vitro (see text for references). We have shown that movement of the tendon is required to produce a functional tendon apparatus in the embryo and predict that movement is also required for regeneration after injury.
mesh_terms: D000818:Animals; D002642:Chick Embryo; D005528:Foot; D009068:Movement; D010243:Paralysis / Q000139:chemically induced / Q000196:embryology; D013583:Synovial Membrane / Q000196:embryology / Q000648:ultrastructure; D013710:Tendons / Q000196:embryology* / Q000648:ultrastructure; D014403:Tubocurarine
chemical_list: D014403:Tubocurarine