Effect of physostigmine on Y-maze discrimination retention in the rat.
A series of experiments was designed to assess the effect of physostigmine on the retention of an appetitively-reinforced Y-maze discrimination. The results supported in part the model of cholinergic involvement in long-term memory as proposed by Deutsch, in that physostigmine respectively impaired and enhanced well-remembered and poorly-remembered responses. However a modification of the model was presented to accommodate futher findings that variations in both dose-level of administered physostigmine and initial leraning ability influenced subsequent retention, depending on the training-testing interval.
D000818:Animals; D004193:Discrimination Learning / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D008297:Male; D008568:Memory / Q000187:drug effects*; D010275:Parasympathetic Nervous System / Q000502:physiology; D010830:Physostigmine / Q000494:pharmacology*; D051381:Rats; D012153:Retention, Psychology / Q000187:drug effects* / Q000502:physiology; D013997:Time Factors
D010830:Physostigmine