Gas embolism due to intravenous FC 80 liquid fluorocarbon.
Lethal gas embolism always occurs after FC 80 liquid fluorocarbon is injected intravenously (0.1 ml/kg body mass) in dogs breathing room air but not in dogs breathing oxygenated FC 80 liquid fluorocarbon. Gas embolism is not prevented in dogs that have been injected intravenously with FC 80 when they are exposed to 2 ATA (atmospheres absolute) 20% 02-80% N2, 9 ATA 5% O2-95% He, or 1 ATA 100%, O2. In dogs that die of FC 80-induced gas embolism, free gas in the right atrium contains approximately 0.5 g FC 80/liter, and Po2 and Pco2 in the gas are in equilibrium with their corresponding tensions in right atrial blood. These observations are consistent with the hypothesis that PFC 80 in alveolar gas does not equilibrate with PFC 80 (55 mmHg) in blood. The total gas tension in pulmonary capillary blood containing FC 80 and its vapor thus exceeds the total tension of alveolar gases (atmospheric pressure). Bubbles of O2, CO2, N2, FC 80, and water vapor form in the regions of the pulmonary capillary bed where the total tension of gases dissolved in blood exceeds the absolute blood pressure.
D000818:Animals; D002245:Carbon Dioxide / Q000097:blood; D002463:Cell Membrane Permeability; D004285:Dogs; D004618:Embolism, Air / Q000139:chemically induced* / Q000503:physiopathology; D005465:Fluorocarbon Polymers / Q000633:toxicity*; D005466:Fluorocarbons / Q000008:administration & dosage / Q000378:metabolism / Q000494:pharmacology / Q000633:toxicity*; D007275:Injections, Intravenous; D010100:Oxygen / Q000097:blood; D010313:Partial Pressure; D011650:Pulmonary Alveoli / Q000502:physiology; D012119:Respiration
D005465:Fluorocarbon Polymers; D005466:Fluorocarbons; D002245:Carbon Dioxide; D010100:Oxygen