Distribution and arteriovenous shunting of gastric blood flow in the baboon: effect of epinephrine and vasopressin infusions.
The effects of 60-min intraarterial infusion of vasopressin (0.005 U per kg-min) and epinephrine (0.05 mu per kg-min) on gastric hemodynamics were studied in anesthetized baboons. Total gastric blood flow was measured electromagnetically and radioactive microspheres (15 +/- 5 mu) with three labels were used to determine regional distribution of gastric blood flow and arteriovenous shunting. Control flow was 55 +/- 8 ml per min, with 77.4 +/- 2.7% of flow going to the gastric mucosa and 1.7 +/- 0.4% of injected spheres appearing in the liver. Epinephrine infusion resulted in a sustained vasoconstriction to 18 +/- 5 ml per min with no autoregulatory escape and no changes in arterial pressure or cardiac output. Vasopressin resulted in a decrease in flow to 14 +/- 3 ml per min with no excape. Whereas cardiac output did not change, there was a singificant hypertensive effect during the vasopressin infusion. There was neither redistribution of flow nor change in arteriovenous shunting with either epinephrine or vasopressin. Transmucosal electrical potential difference was 62 +/- 8 mv and did not change significantly with either infusion.
D000818:Animals; D001163:Arteriovenous Anastomosis / Q000187:drug effects*; D001783:Blood Flow Velocity; D001794:Blood Pressure / Q000187:drug effects; D002245:Carbon Dioxide / Q000097:blood; D002302:Cardiac Output; D004837:Epinephrine / Q000494:pharmacology*; D005753:Gastric Mucosa / Q000098:blood supply; D006439:Hemodynamics / Q000187:drug effects*; D008564:Membrane Potentials / Q000187:drug effects; D010100:Oxygen / Q000097:blood; D010215:Papio; D012039:Regional Blood Flow; D013270:Stomach / Q000098:blood supply*; D014667:Vasopressins / Q000494:pharmacology*
D014667:Vasopressins; D002245:Carbon Dioxide; D010100:Oxygen; D004837:Epinephrine