[Influence of inflammation on prostaglandin metabolism in rat skin (author's transl)].
Influence of inflammation on prostaglandin metabolism in rat abdominal skin was studied. Prostaglandin F2alpha content was determined by the radioisotope dilution method. Prostaglandin F2alpha content in rat abdominal skin was increased by thermal burn and application of 2, 4-dinitrochlorobenzene. The incorporation of 3H-arachidonic acid into prostaglandin F2alpha in rat abdominal skin was not increased by inflammation. Indomethacin caused a significant reduction of prostaglandin F2alpha content. These results suggest that the prostaglandin may play an important role in the inflammatory process of rat skin.
D000818:Animals; D001095:Arachidonic Acids / Q000378:metabolism; D002056:Burns / Q000378:metabolism; D004137:Dinitrochlorobenzene; D007213:Indomethacin / Q000494:pharmacology; D007249:Inflammation / Q000139:chemically induced / Q000378:metabolism*; D008297:Male; D011460:Prostaglandins F / Q000096:biosynthesis / Q000378:metabolism*; D051381:Rats; D012867:Skin / Q000378:metabolism*
D001095:Arachidonic Acids; D004137:Dinitrochlorobenzene; D011460:Prostaglandins F; D007213:Indomethacin