[Lymph node and spleen morphology in gnotobiotic rats].
The lymph nodes, the spleen and the adrenal cortex were studied in 12 gnotobiotic and 12 control Wistar rats by routine histological and histochemical methods. It was shown that the absence of normal microbial flora suppressed the development of zone B of the lymphocytes in the lymph nodes; it was accompanied by an increase in the thickness of the adrenal cortex and of the lipid inclusions in its cells, but had no influence on the lymph follicles of the spleen. A conclusion was drawn that inhibition of lymphopoiesis in the lymph nodes occurred as a result of absence of a direct microbial stimulation and was mediated via the hormonal factors; this failed to influence the lymphopoiesis of the spleen maintained by stimulation within the organ itself.
D000302:Adrenal Cortex / Q000166:cytology; D000818:Animals; D005856:Germ-Free Life; D008198:Lymph Nodes / Q000166:cytology*; D051381:Rats; D013154:Spleen / Q000166:cytology*
Morfologiia limfaticheskogo uzla i selezenki gnotobioticheskoĭ krysy