Imipramine enhancement of pentobarbital toxicity in rats.
The toxicity of pentobarbital was examined in male Wistar rats pretreated with a non-toxic dose of imipramine (10 mg/kg, po). Pentobarbital (70 mg/kg, ip) lethality was enhanced up to 6 hr after imipramine administration, and pentobarbital (45 mg/kg, ip) sleeping time was prolonged up to 12 hr after imipramine. Physiological measurements showed that imipramine pretreatment 2 hr prior to pentobarbital (70 mg/kg, ip) enhanced barbiturate depression in mean blood pressure, oxygen consumption and respiration rate, but not in heart rate or back skin temperature. Analysis of brain radioactivity after [14C] pentobarbital indicated that these effects of imipramine were not solely the result of inhibition of liver metabolism.
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D001921:Brain / Q000378:metabolism; D004334:Drug Administration Schedule; D004357:Drug Synergism; D006339:Heart Rate / Q000187:drug effects; D007099:Imipramine / Q000097:blood / Q000494:pharmacology*; D008297:Male; D010101:Oxygen Consumption / Q000187:drug effects; D010424:Pentobarbital / Q000378:metabolism / Q000633:toxicity*; D051381:Rats; D012119:Respiration / Q000187:drug effects; D012881:Skin Temperature / Q000187:drug effects; D012890:Sleep / Q000187:drug effects; D013997:Time Factors
D010424:Pentobarbital; D007099:Imipramine