[Metabolic effects of acute experimental hypoxia and hypercapnia].
Hypoxia and the hypercapnia were produced in anesthetized dogs by artificial respiration with appropriate gas mixtures, and a study was conducted of the effects of these conditions on various metabolic parameters, viz. catecholamines, renin activity, lactate, pyruvate, cortisol, non-esterified free fatty acids (FFA), and ammonia, in the plasma of the arterial blood. Hypercapnia caused a distinct increase in catecholamine concentrations, renin activity and ammonia, and a decrease in lactate and pyruvate; cortisol and FFA levels were only slightly altered. Hypoxia increased lactate, pyruvate and--though only to a slight extent--FFA, cortisol and NH3. The changes induced by hypercapnia were chiefly attributable to activation of the sympathico-adrenal system; those induced by hypoxia were not.
D000641:Ammonia / Q000097:blood; D000818:Animals; D002395:Catecholamines / Q000097:blood; D004285:Dogs; D005230:Fatty Acids, Nonesterified / Q000097:blood; D006854:Hydrocortisone / Q000097:blood; D006935:Hypercapnia / Q000378:metabolism*; D000860:Hypoxia / Q000378:metabolism*; D007773:Lactates / Q000097:blood; D011773:Pyruvates / Q000097:blood; D012083:Renin / Q000097:blood
D002395:Catecholamines; D005230:Fatty Acids, Nonesterified; D007773:Lactates; D011773:Pyruvates; D000641:Ammonia; D012083:Renin; D006854:Hydrocortisone
Metabolische Auswirkungen einer akuten experimentellen Hypoxie oder Hyperkapnie.