title: Effect of perfusion of bile salts solutions into the oesophagus of hiatal hernia patients and controls.
abstract: Tests of the response to perfusion of the oesophagus were made in 54 patients divided into three groups. Group I consisted of patients with symptomatic hiatal hernia, group II hiatal hernia patients with peptic stricture, and group III normal individuals. Each individual oesophagus was perfused at a rate of 45-65 drops per minute over 25 minutes with six solutions: normal saline, N/10 HCl, taurine conjugates of bile salts in normal saline, taurine conjugates of bile salts in N/10 HCl, glycine conjugates of bile salts in normal saline, and taurine and glycine conjugates in a ratio of 1 to 2 in normal saline. It was found that acidified taurine solutions were more irritating than acid alone. With a 2mM/l solution of taurine in acid, symptoms are produced even in controls. With a 1 mM/l solution of the same conjugates, the majority of normal people feel slight heartburn or nothing, and therefore perfusion into the oesophagus of such a solution could be used as a test for oesophagitis.
mesh_terms: D001647:Bile Acids and Salts / Q000494:pharmacology*; D004941:Esophagitis / Q000175:diagnosis; D004947:Esophagus / Q000187:drug effects*; D006356:Heartburn / Q000139:chemically induced; D006548:Hernia, Diaphragmatic / Q000503:physiopathology*; D006551:Hernia, Hiatal / Q000503:physiopathology*; D006801:Humans; D006851:Hydrochloric Acid / Q000494:pharmacology; D009325:Nausea / Q000139:chemically induced; D013654:Taurine / Q000494:pharmacology; D013997:Time Factors; D014839:Vomiting / Q000139:chemically induced
chemical_list: D001647:Bile Acids and Salts; D013654:Taurine; D006851:Hydrochloric Acid