Age-related changes in the reducible cross-links of human dermis collagen.
Samples of normal human dermis of different ages are reduced with tritiated sodium borohydride and changes of major reducible cross-links are compared as a function of chronological age. While lysinorleucine practically remains constant, reduced desmosine changes slightly, hydroxylysinoroleucine and dihydroxylysinonorleucine display a marked decrease with age. An unknown compound is shown to increase with aging. The data suggest a correlation between the change of aldimine cross-links and the structural and/or biochemical changes occurring with increase in age.
D000328:Adult; D000367:Age Factors; D000368:Aged; D000375:Aging; D001894:Borohydrides; D002675:Child, Preschool; D003094:Collagen / Q000378:metabolism*; D003895:Desmosine / Q000032:analysis; D006801:Humans; D007231:Infant, Newborn; D008239:Lysine / Q000032:analysis; D008875:Middle Aged; D009646:Norleucine / Q000032:analysis; D012867:Skin / Q000378:metabolism*
D001894:Borohydrides; D003895:Desmosine; D009646:Norleucine; D003094:Collagen; D008239:Lysine