Overdiagnosis and overtreatment of pulmonary embolism: the emperor may have no clothes.
Pulmonary embolism is being overdiagnosed and overtreated, especially in previously normal women using oral contraceptives, with undesirable consequences in heparin treatment. This is in part a consequences of high estimates of its occurrence based on postmortem data and in part of technologic developments in diagnostic methods. Blood gas data are not diagnostically very helpful. Perfusion scans should be used, largely to exclude the diagnosis. Ventilation scans are only occasionally helpful and are expensive. Pulmonary angiography is the most accurate diagnostic means currently available. Further studies are needed to elucidate the prevalence and natural life history of pulmonary embolism in the previously healthy person.
D000792:Angiography / Q000009:adverse effects; D000925:Anticoagulants / Q000009:adverse effects; D001777:Blood Coagulation; D003280:Contraceptives, Oral, Synthetic / Q000009:adverse effects; D003951:Diagnostic Errors; D005260:Female; D006801:Humans; D010100:Oxygen / Q000097:blood; D011247:Pregnancy; D011651:Pulmonary Artery / Q000000981:diagnostic imaging; D011655:Pulmonary Embolism / Q000139:chemically induced / Q000175:diagnosis / Q000000981:diagnostic imaging / Q000453:epidemiology / Q000628:therapy; D011877:Radionuclide Imaging; D012119:Respiration; D013300:Streptokinase / Q000009:adverse effects; D014568:Urokinase-Type Plasminogen Activator / Q000009:adverse effects
D000925:Anticoagulants; D003280:Contraceptives, Oral, Synthetic; D013300:Streptokinase; D014568:Urokinase-Type Plasminogen Activator; D010100:Oxygen