Effects of excess vitamin A on the cranial neural crest in the chick embryo.
Experiments on fertile hens' eggs have shown that an excess of vitamin A has a highly specific effect on the migration of cranial neural crest cells in the early stages of chick embryogenesis. Migration is disrupted and retarded. This is consistent with the causal mechanism proposed by Poswillo for the Treacher Collins syndrome.
D000818:Animals; D002465:Cell Movement / Q000187:drug effects; D002642:Chick Embryo; D005724:Ganglia / Q000166:cytology; D008342:Mandibulofacial Dysostosis / Q000209:etiology; D009420:Nervous System / Q000187:drug effects / Q000196:embryology*; D014801:Vitamin A / Q000494:pharmacology*
D014801:Vitamin A