title: Reserpine-induced dissociation of canine pancreatic secretion.
abstract: In five dogs, provided with chronic pancreatic and gastric fistulas (Thomas' cannula), the effects on exocrine pancreatic secretion of an intravenous continuous perfusion of gastrin (Eurorga, hog gastrin I-II, 6 mug./kg./hr.) and secretin (GIH, 0.5 C.U./kg.hr.) was studied before and after 48 hours of reserpine treatment (0.1 mg./kg./24 hr.). When compared with the pretreated plateau levels, reserpine induced a significant pancreatic secretion dissociation, a depressive of the alkaline and a rising of the protein component. The former phenomenon suggests a participation of a catecholamines in the secretin-elicited pancreatic electrolyte secretion. The latter, an enhanced sensitivity of intranpancreatic and/or acinar cells of the "pancreon" to gastrin stimulation.
mesh_terms: D000818:Animals; D001639:Bicarbonates / Q000378:metabolism; D004285:Dogs; D005755:Gastrins; D010179:Pancreas / Q000378:metabolism* / Q000502:physiology; D011506:Proteins / Q000378:metabolism; D012110:Reserpine / Q000494:pharmacology*; D012633:Secretin
chemical_list: D001639:Bicarbonates; D005755:Gastrins; D011506:Proteins; D012633:Secretin; D012110:Reserpine