title: Differences in muscle blood flow in upper and lower extremities of patients after correction of coarctation of the aorta.
abstract: Using the method 133Xe clearance we investigated blood flow and calculated vascular resistances simultaneously in the muscles of the upper and lower extremities in 58 patients following successful surgical correction of aortic coarctation carried out at age 11.5 (+/- 2.9) years. The interval from operation to investigation was 11.5 (+/- 4.5) years. Resting and maximal ischemic exercise blood flows in the upper extremity were decreased and the duration of maximal blood flow was shortened. Values recorded from the lower extremities did not differ from normal controls. The difference between upper and lower extremities was statistically significant. Vascular resistance during maximal blood flow was higher in the upper extremities than in the lower. Differences between upper and lower extremities did not change after vasodilation elicited by amyl nitrite. The degree of differences was not dependent upon the age at operation, the age of the patients at investigation, or on the time interval between operation and investigation.
mesh_terms: D000328:Adult; D000680:Amyl Nitrite / Q000494:pharmacology; D001017:Aortic Coarctation / Q000601:surgery*; D001783:Blood Flow Velocity; D001794:Blood Pressure / Q000187:drug effects; D005260:Female; D005542:Forearm / Q000098:blood supply*; D006439:Hemodynamics / Q000187:drug effects; D006801:Humans; D007866:Leg / Q000098:blood supply*; D008297:Male; D009132:Muscles / Q000098:blood supply*; D011183:Postoperative Complications / Q000503:physiopathology*; D012039:Regional Blood Flow; D013997:Time Factors; D014655:Vascular Resistance / Q000187:drug effects
chemical_list: D000680:Amyl Nitrite