Potentiation by lithium and protection by rubidium of digitalis intoxication.
Investigating the effects of Li and Rb on the toxicity of digoxin and ouabain revealed Li to be a potentiator while Rb to be a protector. The effects of Rb in this respect are, more or less, qualitatively comparable to those of K; the intensity of Rb effects is more than that of K. In case of digoxin the effect produced from the combined use of both Rb and K is more than each individual effect. With ouabain, however, whereas Rb offered protection K failed to do so. Electrolyte changes in cardiac tissue showed that Li increased the tissue content of Ca while Rb produced the opposite effect. In comparing Rb with K, both increased the K level in the cardiac muscle. However, in the case of ouabain the infusion of K failed to decrease the Ca level and this might explain its failure to protect against ouabain toxicity. This points to the importance of Ca, rather than K, in controlling the excitability of the cardiac muscle and in effecting the toxicity of cardiac glycosides. Evidences presented indicate the superiority of Rb over K and propose its trial in clinical practice.
D000818:Animals; D004071:Digitalis Glycosides / Q000097:blood; D004077:Digoxin / Q000037:antagonists & inhibitors / Q000633:toxicity*; D004357:Drug Synergism; D004573:Electrolytes / Q000378:metabolism; D005260:Female; D006168:Guinea Pigs; D007928:Lethal Dose 50; D008094:Lithium / Q000494:pharmacology*; D008297:Male; D009206:Myocardium / Q000378:metabolism; D010042:Ouabain / Q000633:toxicity; D011188:Potassium / Q000494:pharmacology; D012413:Rubidium / Q000494:pharmacology*
D004071:Digitalis Glycosides; D004573:Electrolytes; D010042:Ouabain; D004077:Digoxin; D008094:Lithium; D012413:Rubidium; D011188:Potassium