[Regulation of lipid and carbohydrate metabolism of the heart by carbocromen (author's transl)].
The influence of 3-(2-diethylaminoethyl)-4-methyl-7-(carbethoxy-methoxy)-2-oxo-1,2-chromene-hydrochloride (carbocromen, Intensain) on lipid and carbohydrate metabolism of the heart was investigated. Carbocromen inhibits the incorporation of 14C-palmitate in heart slices of the rat. The degree of inhibition is dose-dependent and can reach a maximum of 30%. However, the relative concentrations of the various lipid components do not vary significantly. In the heart tissue of the mouse carbocromen increases the uptake of 14C-3-O-methyl-D-glucose by about 30% which might be due to an increased influx of glucose into the heart. The metabolic degradation of 14C-palmitate to 14CO2 decreases up to 40% in the presence of carbocromen with a parallel reduction in oxygen consumption.
D000818:Animals; D002866:Chromonar / Q000494:pharmacology*; D003374:Coumarins / Q000494:pharmacology*; D003864:Depression, Chemical; D004305:Dose-Response Relationship, Drug; D005230:Fatty Acids, Nonesterified / Q000378:metabolism; D005947:Glucose / Q000378:metabolism; D006321:Heart / Q000187:drug effects; D008297:Male; D008757:Methylglucosides / Q000378:metabolism*; D008759:Methylglycosides / Q000378:metabolism*; D051379:Mice; D009206:Myocardium / Q000378:metabolism*; D010101:Oxygen Consumption; D010168:Palmitates / Q000378:metabolism*; D010169:Palmitic Acids / Q000378:metabolism*; D010743:Phospholipids / Q000378:metabolism; D051381:Rats; D014280:Triglycerides / Q000378:metabolism
D003374:Coumarins; D005230:Fatty Acids, Nonesterified; D008757:Methylglucosides; D008759:Methylglycosides; D010168:Palmitates; D010169:Palmitic Acids; D010743:Phospholipids; D014280:Triglycerides; D005947:Glucose; D002866:Chromonar
Regulation des Fett- und Kohlenhydratstoffwechsels des Herzens durch Carbocromen