Chemotherapy of childhood medulloblastoma.
A number of chemotherapeutic agents have been shown to have anti-tumor activity against childhood medulloblastoma. Ten-year survival with optimal surgery and radiation therapy ranges from 5% to 25%. Carefully controlled clinical trials utilizing a combination of surgery, radiation therapy, and chemotherapy should be employed in the early stages of the disease in an attempt to define which drugs are most effective, and to improve the survival rate.
D000293:Adolescent; D000328:Adult; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D001932:Brain Neoplasms / Q000188:drug therapy* / Q000532:radiotherapy; D002648:Child; D003520:Cyclophosphamide / Q000627:therapeutic use; D003907:Dexamethasone / Q000627:therapeutic use; D004317:Doxorubicin / Q000627:therapeutic use; D005260:Female; D006050:Gold Radioisotopes / Q000627:therapeutic use; D006801:Humans; D008297:Male; D008527:Medulloblastoma / Q000188:drug therapy* / Q000532:radiotherapy; D008727:Methotrexate / Q000627:therapeutic use; D009607:Nitrosourea Compounds / Q000627:therapeutic use; D011034:Podophyllotoxin / Q000627:therapeutic use; D011344:Procarbazine / Q000627:therapeutic use; D011867:Radioisotope Teletherapy; D012673:Semustine / Q000627:therapeutic use; D013866:Thioguanine / Q000627:therapeutic use; D014265:Triethylenemelamine / Q000627:therapeutic use; D014750:Vincristine / Q000627:therapeutic use
D000970:Antineoplastic Agents; D006050:Gold Radioisotopes; D009607:Nitrosourea Compounds; D012673:Semustine; D011344:Procarbazine; D014750:Vincristine; D003907:Dexamethasone; D004317:Doxorubicin; D003520:Cyclophosphamide; D014265:Triethylenemelamine; D013866:Thioguanine; D011034:Podophyllotoxin; D008727:Methotrexate