title: Investigation on cyclic guanidine derivatives. Part III. Synthesis and properties of 2-piperidino and 2-homopiperidino-tetrahydropyrimidine-4,6-dione derivatives.
abstract: A series of 2-piperidino-(1a-k) and 2-homopiperidino-(2a-k)-tetrahydropyrimidine-4,6-diones was synthesized. The structure of the compounds was confirmed by elemental analysis and UV spectra. Compounds 1a, 1j, 2a and 2k showed the antidepressant activity.
mesh_terms: D000818:Animals; D004295:Dihydroxyphenylalanine / Q000494:pharmacology; D051379:Mice; D008996:Monoamine Oxidase Inhibitors; D009043:Motor Activity / Q000187:drug effects; D010880:Piperidines / Q000138:chemical synthesis / Q000494:pharmacology; D011744:Pyrimidinones / Q000138:chemical synthesis* / Q000494:pharmacology
chemical_list: D008996:Monoamine Oxidase Inhibitors; D010880:Piperidines; D011744:Pyrimidinones; D004295:Dihydroxyphenylalanine