title: Vitiligo and juvenile diabetes mellitus.
abstract: Five juvenile diabetics had vitiligo. In two children, the vitiligo preceded the onset of diabetes. Four of the five patients had thyroid, adrenal, or gastric antibodies or a combination of these. In three children HLA-B8 antigens were detected, and one additional patient had HLA-Bw15. Of eight nondiabetic children with vitiligo, one had abnormal glucose tolerance. To the evidence supporting an autoimmune form of diabetes mellitus we add another observation: the association of insulin-dependent diabetes and childhood vitiligo.
mesh_terms: D000293:Adolescent; D000328:Adult; D001323:Autoantibodies / Q000032:analysis; D002648:Child; D002675:Child, Preschool; D003922:Diabetes Mellitus, Type 1 / Q000097:blood / Q000150:complications* / Q000276:immunology; D005260:Female; D005951:Glucose Tolerance Test; D006680:HLA Antigens / Q000145:classification; D006801:Humans; D008297:Male; D014820:Vitiligo / Q000097:blood / Q000150:complications* / Q000276:immunology
chemical_list: D001323:Autoantibodies; D006680:HLA Antigens