Tolbutamide treatment of pregnant mice: repeated administration reduces fetal lethality.
Pretreatment of pregnant BALB/c mice with several low doses of tolbutamide protected against the fetolethal effects of a high dose. Pregnant mice were given single ip injections of 400 mg/kg in saline on day 13; 100 mg/kg/day on days 10, 11, 12, and 13; or 100 mg/kg/day on days 10, 11, and 12 and 400 mg/kg on day 13. On day 16 the single-treatment group had a significantly higher resorption rate than any other group. Fetolethality was not related to hypoglycemia. The protective effect of pretreatment may have been due to induction of maternal microsomal enzymes.
D000014:Abnormalities, Drug-Induced; D000818:Animals; D004790:Enzyme Induction; D005260:Female; D005313:Fetal Death / Q000139:chemically induced*; D005327:Fetal Resorption / Q000139:chemically induced; D005333:Fetus / Q000033:anatomy & histology; D007003:Hypoglycemia / Q000139:chemically induced; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D011247:Pregnancy; D012965:Sodium Chloride; D012996:Solutions; D013997:Time Factors; D014044:Tolbutamide / Q000008:administration & dosage / Q000494:pharmacology / Q000633:toxicity*; D014867:Water
D012996:Solutions; D014867:Water; D012965:Sodium Chloride; D014044:Tolbutamide