Pharmacokinetics of lidocaine after prolonged intravenous infusions in uncomplicated myocardial infarction.
The kinetics of the elimination of lidocaine upon discontinuation of lidocaine infusions lasting more than 24 h were studied in 12 patients with uncomplicated myocardial infarctions. In this group of patients the mean half-life of the elimination phase was found to be 3.22 h. This is significantly different from the half-life of 100 min that has been reported after bolus injections or infusions lasting less than 12 h. This longer half-life should be taken into consideration in estimating the duration of toxicity and the rate of administration of the drug during and after intravenous infusions lasting 24 h or more.
D005260:Female; D006207:Half-Life; D006801:Humans; D007263:Infusions, Parenteral; D007700:Kinetics; D008012:Lidocaine / Q000008:administration & dosage / Q000009:adverse effects / Q000378:metabolism*; D008297:Male; D009203:Myocardial Infarction / Q000378:metabolism*
D008012:Lidocaine