title: Nephropathy caused by methicillin therapy for staphylococcal septicemia.
abstract: Nephropathy, eosinophilia and fever were observed in an 18-year-old man being treated for staphylococcal septicemia. Parenteral challenge with suspected sensitizing agents confirmed methicillin as the likely offender. Review of the literature relating to methicillin-induced nephropathy suggests a hypersensitivity origin for this disorder, but immunologic and ultrastructural investigation to date has failed to elucidate pathogenesis.
mesh_terms: D000293:Adolescent; D002981:Clindamycin / Q000009:adverse effects; D003429:Cross Reactions; D004342:Drug Hypersensitivity; D004802:Eosinophilia / Q000139:chemically induced; D005334:Fever / Q000139:chemically induced; D006801:Humans; D007674:Kidney Diseases / Q000139:chemically induced* / Q000276:immunology / Q000473:pathology; D008297:Male; D008712:Methicillin / Q000009:adverse effects* / Q000276:immunology / Q000627:therapeutic use; D018805:Sepsis / Q000188:drug therapy; D013203:Staphylococcal Infections / Q000188:drug therapy / Q000401:mortality
chemical_list: D002981:Clindamycin; D008712:Methicillin