Plasma levels of the methyl ester of 15-methyl PGF2alpha in connection with intravenous and vaginal administration to the human.
After intravenous injection of the methyl ester of 15-methyl-PGF2alpha the drug initially disappeared faster than the corresponding free acid, but still after one hour, about 1% of the active drug is circulating in plasma. Vaginal administration of single suppositories containing 1 mg of 15-methyl-PGF2alpha methyl ester and determination of plasma levels using gas chromatography-mass spectrometry demonstrated that the highest plasma levels were reached after 1.5-3 hours. Vaginal suppositories were administered according to different dose schedules for induction of abortion and plasma levels of 15-methyl-PGF2alpha and it's ester were determined. There seemed to be a gross correlation between given doses and obtained plasma level. The data will serve as basis for further development of vaginal delivery devices.
D000032:Abortion, Therapeutic; D000143:Acids / Q000097:blood; D002845:Chromatography; D002849:Chromatography, Gas; D002853:Chromatography, Liquid; D004952:Esters / Q000097:blood; D005260:Female; D006801:Humans; D007275:Injections, Intravenous; D013058:Mass Spectrometry; D011247:Pregnancy; D011460:Prostaglandins F / Q000008:administration & dosage / Q000097:blood* / Q000627:therapeutic use; D013488:Suppositories; D014621:Vagina
D000143:Acids; D004952:Esters; D011460:Prostaglandins F; D013488:Suppositories