Effect of propylthiouracil on intestinal tumor formation by azoxymethane in rats.
Treatment with propylthiouracil (PTU) resulted in a significant decrease in azoxymethane-induced intestinal tumors, total concentration of fecal bile acids as well as the fecal neutral steroids, cholesterol and coprostanol. Thus, a hypothyroid state induced by PTU treatment may affect intestinal carcinogenesis in this animal model by lowering the concentration of fecal bile acids and neutral steroids.
D000230:Adenocarcinoma / Q000139:chemically induced*; D000818:Animals; D001391:Azo Compounds; D001397:Azoxymethane; D001647:Bile Acids and Salts / Q000032:analysis; D005243:Feces / Q000032:analysis; D007414:Intestinal Neoplasms / Q000139:chemically induced*; D008297:Male; D011441:Propylthiouracil / Q000494:pharmacology*; D051381:Rats; D013256:Steroids / Q000032:analysis
D001391:Azo Compounds; D001647:Bile Acids and Salts; D013256:Steroids; D011441:Propylthiouracil; D001397:Azoxymethane