Effect of indomethacin on pulmonary vasomotor response in patients with mitral stenosis.
In 10 patients with mitral stenosis, ingestion of 125 mg indomethacin over a 24-h period had no effect on the elevated pressure in pulmonary artery. It did, however, in all patients, slightly potentiate a fall in pulmonary pressure induced by breathing of 100% oxygen. The results do not suggest that a prostaglandin mechanism is involved in chronic pulmonary vasoconstriction or that this mechanism is responsible for acute vasodilatation of the pulmonary bed induced by oxygen inhalation.
D000328:Adult; D001794:Blood Pressure / Q000187:drug effects; D005260:Female; D006801:Humans; D007213:Indomethacin / Q000494:pharmacology*; D008297:Male; D008875:Middle Aged; D008946:Mitral Valve Stenosis / Q000503:physiopathology*; D011453:Prostaglandins / Q000502:physiology; D011652:Pulmonary Circulation / Q000187:drug effects*; D014666:Vasomotor System / Q000187:drug effects*
D011453:Prostaglandins; D007213:Indomethacin