Granuloma formation in lungs of mice after intravenous administration of emulsified trehalose-6,6'-dimycolate (cord factor): reaction intensity depends on size distribution of the oil droplets.
The intensity of the granulomatous reaction evoked in lungs of mice by trehalose-6,6'-dimycolate administered intravenously in oil-water emulsion depended on the size distribution of the oil droplets. Emulsions containing the greatest number of the largest oil droplets were the most granulomagenic.
D000818:Animals; D003311:Cord Factors / Q000008:administration & dosage; D004655:Emulsions; D006017:Glycolipids / Q000008:administration & dosage; D006099:Granuloma / Q000139:chemically induced*; D007275:Injections, Intravenous; D008171:Lung Diseases / Q000139:chemically induced*; D008297:Male; D051379:Mice; D009821:Oils; D010316:Particle Size; D011136:Polysorbates
D003311:Cord Factors; D004655:Emulsions; D006017:Glycolipids; D009821:Oils; D011136:Polysorbates