Offset-induced audiogenic seizures.
A relatively stereotyped seizure reaction can be triggered by the "offset" of an intense bell sound in C57BL/6J mice. Susceptibility to this offset-induced audiogenic seizure was found to depend upon the age of the animals tested (higher in older mice) and the duration of the noise exposure (more effective with longer exposure).
D000161:Acoustic Stimulation / Q000009:adverse effects*; D000375:Aging; D000818:Animals; D003213:Conditioning, Psychological; D051379:Mice; D008810:Mice, Inbred C57BL; D012640:Seizures / Q000209:etiology*; D013997:Time Factors