Use of high-pressure liquid chromatography for quantitative structure-activity relationship studies of sulfonamides and barbiturates.
Retention volumes for a group of sulfonamides obtained on three different HPLC columns were correlated with log P, pKa, and biological activity. Depending on the chromatographic system, good correlations can be obtained with log P or with biological activity, but not necessarily both, using the same chromatographic data.
D000818:Animals; D001463:Barbiturates / Q000494:pharmacology*; D001921:Brain / Q000378:metabolism; D002455:Cell Division / Q000187:drug effects; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D002851:Chromatography, High Pressure Liquid; D002855:Chromatography, Thin Layer; D004447:Echinodermata; D005260:Female; D066298:In Vitro Techniques; D008722:Methods; D010063:Ovum / Q000187:drug effects; D010101:Oxygen Consumption / Q000187:drug effects; D051381:Rats; D013329:Structure-Activity Relationship; D013449:Sulfonamides / Q000494:pharmacology*
D001463:Barbiturates; D013449:Sulfonamides