Role of histidine-decarboxylase inhibitors on gastric acid secretion in the rat.
The comparison between DL-alpha-(hydrazino)-beta-4(5)imidazolyl-propionic acid (alpha-HH) and DL-gamma-N(1,2,3,4-tetrahydroisoquinolyl)-alpha-hydrazino-butyric acid (AIS 48), a new inhibitor of histidine-decarboxylase shows that both compounds inhibit enzyme activity in vitro and lower gastric histamine content and acid secretion in vivo. The potency of AIS 48 is of the same order as that of alpha-HH while its toxicity is lower. Although AIS 48 is not a selective histidine-decarboxylase inhibitor, it does not affect tissue cathecholamine levels.
D000818:Animals; D002087:Butyrates / Q000494:pharmacology; D002262:Carboxy-Lyases / Q000037:antagonists & inhibitors*; D004298:Dopamine / Q000378:metabolism; D004305:Dose-Response Relationship, Drug; D005750:Gastric Juice / Q000378:metabolism*; D005753:Gastric Mucosa / Q000378:metabolism; D006168:Guinea Pigs; D006632:Histamine / Q000378:metabolism / Q000494:pharmacology; D006639:Histidine / Q000031:analogs & derivatives* / Q000494:pharmacology; D006640:Histidine Decarboxylase / Q000037:antagonists & inhibitors*; D006834:Hydrazines / Q000494:pharmacology*; D007546:Isoquinolines / Q000494:pharmacology*; D007668:Kidney / Q000201:enzymology; D008297:Male; D009206:Myocardium / Q000378:metabolism; D009638:Norepinephrine / Q000378:metabolism; D051381:Rats; D012110:Reserpine / Q000494:pharmacology
D002087:Butyrates; D006834:Hydrazines; D007546:Isoquinolines; D006639:Histidine; D006632:Histamine; D012110:Reserpine; D002262:Carboxy-Lyases; D006640:Histidine Decarboxylase; D004298:Dopamine; D009638:Norepinephrine