title: Variants of the HR strain of Sindbis virus lethal for mice.
abstract: We have selected two similar variants of Sindbis HR virus which are lethal for mice. Consecutive brain to brain passage series were conducted in suckling and weanling mice. Specific anti-Sindbis HR neutralization tests and protection tests demonstrate that these viruses are derived from the parent Sindbis HR.
mesh_terms: D000818:Animals; D000956:Antigens, Viral / Q000032:analysis; D002642:Chick Embryo; D046508:Culture Techniques; D014644:Genetic Variation; D007114:Immunization; D051379:Mice; D012845:Sindbis Virus / Q000254:growth & development / Q000276:immunology / Q000472:pathogenicity*; D014774:Virulence; D014779:Virus Replication
chemical_list: D000956:Antigens, Viral