Biological equivalence of ophthalmic prednisolone acetate suspensions.
We compared both concentrations (0.125 and 1.0%) of two widely used commmerical brands of prednisolone acetate suspensions. We investigated the concentration that each product attained in the cornea and aqueous humor, and each product's anti-inflammatory effectiveness in the cornea. There was no statistically significant difference in the corticosteroid levels measured in cornea or aqueous humor after administration of the two suspensions. Similarly, there was no significant difference in the ability of the two commercial preparations to suppress corneal inflammation.
D000085:Acetates / Q000378:metabolism*; D000287:Administration, Topical; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000378:metabolism* / Q000627:therapeutic use; D001082:Aqueous Humor / Q000378:metabolism*; D003315:Cornea / Q000378:metabolism*; D007634:Keratitis / Q000188:drug therapy; D009883:Ophthalmic Solutions; D011239:Prednisolone; D011817:Rabbits; D013810:Therapeutic Equivalency
D000085:Acetates; D000893:Anti-Inflammatory Agents; D009883:Ophthalmic Solutions; D011239:Prednisolone