Suppression of ethanol withdrawal by dopamine.
An ethanol-inhalation technique was used to determine a potential relationship between dopamine and central nervous effects produced by alcohol. Both L-DOPA and intracranially injected dopamine resulted in attenuation of ethanol-induced withdrawal convulsion scores, whereas, haloperidol, a known dopaminergic blocker was found to significantly increase convulsion scores.
D000818:Animals; D004298:Dopamine / Q000627:therapeutic use*; D000431:Ethanol; D006220:Haloperidol / Q000494:pharmacology; D006801:Humans; D007980:Levodopa / Q000627:therapeutic use; D051379:Mice; D012640:Seizures / Q000188:drug therapy; D013375:Substance Withdrawal Syndrome / Q000188:drug therapy; D013997:Time Factors
D000431:Ethanol; D007980:Levodopa; D006220:Haloperidol; D004298:Dopamine