Carrageenin-induced arthritis. I. The effect of intraarticular carrageenin on the chemical composition of articular cartilage.
A single intraarticular injection of carrageenin into rabbit knee joints initiated a localized synovial inflammatory response. This response was accompanied by a 20% loss of proteoglycan from the articular cartilage within 24 hours and by a further 30-60% loss within 5-7 days. The chondrocytes replaced the lost proteoglycan within 42 days. More than two injections caused only a further small decrease in proteoglycan content; the cartilage was then unable to replace the lost proteoglycan. The absence of recovery coincided with the appearance of erosion of the cartilage surface.
D000818:Animals; D001168:Arthritis / Q000139:chemically induced*; D002351:Carrageenan / Q000008:administration & dosage; D002358:Cartilage, Articular / Q000032:analysis / Q000187:drug effects*; D003094:Collagen / Q000032:analysis; D005260:Female; D006025:Glycosaminoglycans / Q000032:analysis; D006603:Hexuronic Acids / Q000032:analysis; D006909:Hydroxyproline / Q000032:analysis; D007270:Injections, Intra-Articular; D007719:Knee Joint; D011509:Proteoglycans / Q000032:analysis / Q000378:metabolism; D011817:Rabbits; D013582:Synovial Fluid
D006025:Glycosaminoglycans; D006603:Hexuronic Acids; D011509:Proteoglycans; D002351:Carrageenan; D003094:Collagen; D006909:Hydroxyproline