title: A comparison for use in radiotherapy of neutron beams generated with 16 and 42 MeV deuterons on beryllium.
abstract: The physical and radiobiological properties of two neutron beams have been compared. The beams were generated by deuterons of 16 MeV at Hammersmith Hospital and 42 MeV at Harwell, in both cases falling on a Be/Cu target. The dose-rate and depth-dose characteristics at the higher energy were found to be superior to those at the lower energy. Collimation and shielding at the higher energy are facilitated by the greater degree of forward-peaking and by the fact that a higher dose-rate allows longer collimators to be used. Attenuation in iron was found to be similar at the two energies. The radiobiological properties of the two neutron beams are very similar. There is a difference of about 20 per cent in RBE for effects on mammalian tissues for doses between 300 and 2,000 rad of neutrons. The OER and the sparing effect of two large fractions are the same for the two beams.
mesh_terms: D000818:Animals; D001608:Beryllium; D002286:Carcinoma, Ehrlich Tumor; D002460:Cell Line; D002470:Cell Survival / Q000528:radiation effects; D003903:Deuterium; D004307:Dose-Response Relationship, Radiation; D005214:Fast Neutrons; D005260:Female; D007082:Ileum / Q000528:radiation effects; D007583:Jejunum / Q000528:radiation effects; D007945:Leukemia, Lymphoid; D051379:Mice; D009502:Neutrons; D011830:Radiation Effects; D011878:Radiotherapy / Q000379:methods; D012867:Skin / Q000528:radiation effects
chemical_list: D003903:Deuterium; D001608:Beryllium