Threonine catabolism in Trypanosoma brucei.
L-Threonine is catabolized by Trypanosoma brucei to give equimolar quantities of glycine and acetate. The pathway, which involves the two enzymes L-threonine dehydrogenase (EC 1.1.1.103) and aminoacetone synthase (acetyl-CoA:glycine C-acetyltransferase, EC 2.3.1.29) and subsequent hydrolysis of the acetyl-CoA, is most active in cultured trypanosomes but is also present in bloodstream forms. L-Threonine dehydrogenase from both culture and bloodstream forms of trypanosomes has an apparent molecular weight of between 28 000 and 38 000, and is sensitive to a wide range of sulphydryl reagents.
D000096:Acetone / Q000031:analogs & derivatives; D000123:Acetyltransferases / Q000378:metabolism; D000429:Alcohol Oxidoreductases / Q000037:antagonists & inhibitors / Q000378:metabolism; D004221:Disulfiram / Q000494:pharmacology; D013912:Threonine / Q000378:metabolism*; D014346:Trypanosoma brucei brucei / Q000201:enzymology / Q000378:metabolism*
D000096:Acetone; D013912:Threonine; D000429:Alcohol Oxidoreductases; D000123:Acetyltransferases; D004221:Disulfiram