Successful use of a totally heparin grafted hemodialysis system in sheep.
A total of 33 totally heparin-grafted dialysis systems using HFAK Cordis Dow Models 3 and 4 have been compared to a total of 23 nongrafted systems. The comparison of deltap, flow rate, FBVL and macroscopic inspection showed highly significant differences in favor of the heparin-grafted systems. The antithrombogenic performance of the totally heparin-grafted systems is mainly due to a small leakage of heparin during the experiments. A minimum of 1.35 X 10(-8) Gm/cm2/min of heparin is sufficient to prevent clotting at the blood-polymer interface.
D000818:Animals; D001775:Blood Circulation; D001777:Blood Coagulation; D002594:Cetylpyridinium; D002712:Chlorides; D006493:Heparin / Q000378:metabolism; D007688:Kidneys, Artificial; D006435:Renal Dialysis / Q000379:methods*; D012756:Sheep
D002712:Chlorides; D006493:Heparin; D002594:Cetylpyridinium