title: Nuclear size classes in the follicular epithelium of lymphoid thyroiditis.
abstract: Nuclear size classes of the type originally described by Jacobj were studied in the follicular epithelium of biopsy smears from lymphoid thyroiditis. Thus, a great number of large nuclei in size classes distinct from the bulk of fairly identically sized nuclei could be clearly distinguished. By cytophotometric measurement of Feulgen-DNA, these large nuclei were found to correspond closely to nuclei in separate DNA-content-classes and they were therefore called HDC-nuclei (High DNA-quantity Class nuclei). Such nuclei proved to be more common in lymphoid thyroiditis than in normal thyroids and non-toxic goitres without lymphoid thyroiditis. Among lymphoid goitres, the percentage of HDC-nuclei was positively correlated with the age of the patients. In the present paper, the relationship between Askanazy cells and HDC-nuclei is also discussed.
mesh_terms: D002467:Cell Nucleus / Q000648:ultrastructure*; D004247:DNA / Q000378:metabolism; D004848:Epithelium / Q000648:ultrastructure; D005260:Female; D006801:Humans; D008297:Male; D013961:Thyroid Gland / Q000648:ultrastructure*; D013967:Thyroiditis, Autoimmune / Q000473:pathology*
chemical_list: D004247:DNA