Hyperimmunoglobulinemia E in a child with allergic bronchopulmonary aspergillosis and bronchiectasis.
A 12-year-old boy was hospitalized for resection of a bronchiectatic lesion. Investigation of an elevated cencentration of serum IgE led to a diagnosis of allergic bronchopulmonary aspergillosis. ABPA has rarely been described in the pediatric age group. This hypersensitivity lung disease is characterized by intermittent wheezing, fever, recurrent pulmonary infiltrates, eosinophilia, hyperimmunoglobulinemia E, and Type I (allergic) skin reactivity to aspergillus extract. Hyphae of aspergillus may also be found in expectorated brown mucus plugs. Type III (Arthus) skin test response and presence of precipitating antibody to this fungus may be demonstrated. Central bronchiectasis or pulmonary fibrosis may result from uncontrolled progression of this disease.
D001228:Aspergillosis / Q000150:complications* / Q000276:immunology; D001982:Bronchial Diseases / Q000150:complications / Q000276:immunology; D001987:Bronchiectasis / Q000150:complications* / Q000473:pathology; D002648:Child; D006801:Humans; D006942:Hypergammaglobulinemia / Q000150:complications* / Q000276:immunology; D007073:Immunoglobulin E; D008168:Lung / Q000473:pathology; D008172:Lung Diseases, Fungal / Q000150:complications* / Q000276:immunology / Q000473:pathology; D008297:Male; D012130:Respiratory Hypersensitivity / Q000150:complications* / Q000276:immunology; D012882:Skin Tests
D007073:Immunoglobulin E