Tubulointerstitial and glomerular nephritis associated with rifampin. Report of a case.
In a patient with tuberculosis and acute renal failure related to administration of therapeutic rifampin, treatment was discontinued for five weeks. It was reinstituted three weeks later. Unlike other patients previously described, the expected adverse renal reaction occurred only gradually and without symptoms, although tubular and glomerular disease developed. Also unique was a striking deposition of immunoglobulin about the tubules. This finding, in association with interstitial nephritis and tubular glycosuria, is similar to an experimental autologous renal disease mediated by antibody to tubular basement membrane.
D058186:Acute Kidney Injury / Q000139:chemically induced*; D001323:Autoantibodies / Q000032:analysis; D001485:Basement Membrane / Q000276:immunology; D003176:Complement C3 / Q000032:analysis; D003404:Creatinine / Q000097:blood; D005340:Fibrinogen / Q000032:analysis; D005921:Glomerulonephritis / Q000139:chemically induced*; D006029:Glycosuria / Q000139:chemically induced; D006801:Humans; D007070:Immunoglobulin A / Q000032:analysis; D007074:Immunoglobulin G / Q000032:analysis; D007684:Kidney Tubules / Q000276:immunology; D008297:Male; D008722:Methods; D008875:Middle Aged; D009395:Nephritis, Interstitial / Q000139:chemically induced*; D012293:Rifampin / Q000008:administration & dosage / Q000009:adverse effects* / Q000627:therapeutic use; D013997:Time Factors; D014397:Tuberculosis, Pulmonary / Q000188:drug therapy
D001323:Autoantibodies; D003176:Complement C3; D007070:Immunoglobulin A; D007074:Immunoglobulin G; D005340:Fibrinogen; D003404:Creatinine; D012293:Rifampin