Resting muscle levels and the influence of exercise on serum amino acid-arylpeptidase activity in man.
Activities of amino acid arylamidases in skeletal muscle and serum of healthy male subjects were investigated using various substrates (Ala-, Leu-, Phe- and S-benxylcysteine-4-nitroanilides). At rest, there is no agreement between muscle and serum activity patterns. After physical exercise, the serum increase of Ala-, Leu- and Phe-AP activities is closely correleated to their respective activities in resting muscles. Since there is no relationship of the postexercise increase of amino acid arylpeptidase activitiy and exercise-induced intrasvascular haemolysis, it appears highly probable that the origin of the serum activity increase after physical work is skeletal muscle.
D000293:Adolescent; D000328:Adult; D000626:Aminopeptidases / Q000097:blood / Q000378:metabolism*; D000813:Anilides; D010122:Cystinyl Aminopeptidase / Q000097:blood; D005080:Exercise Test; D006461:Hemolysis; D006801:Humans; D008297:Male; D008875:Middle Aged; D009132:Muscles / Q000201:enzymology*; D005082:Physical Exertion; D013329:Structure-Activity Relationship
D000813:Anilides; D000626:Aminopeptidases; D010122:Cystinyl Aminopeptidase