[Angioimmunoblastic lymphadenopathies with autoimmune anemia and polyclonal hyperimmunoglobulinemia].
The study concerned 13 cases of angio-immunoblastic lymphadenopathy. This systemic lymphoid disorder has been identified only recently and is surely more common than has been thought. It is characterised by specific changes in the lymph nodes, which are infiltrated by plasmocytic and immunoblastic cells, associated with a marked degree of vascular neogenesis. This anatomical involvement is accompanied by numerous immunological manifestations, the most important of which are a positive Coombs test and a polyclonal hyperimmunoglobulinaemia. Despite the severe course of the disorder, its benign or malignant nature is uncertain and the therapeutic approach remains a subject of discussion.
D000368:Aged; D000744:Anemia, Hemolytic, Autoimmune / Q000175:diagnosis* / Q000276:immunology; D001772:Blood Cell Count; D001796:Blood Protein Disorders / Q000209:etiology; D001854:Bone Marrow Cells; D003298:Coombs Test; D005260:Female; D006801:Humans; D006942:Hypergammaglobulinemia / Q000175:diagnosis* / Q000276:immunology; D007074:Immunoglobulin G; D008198:Lymph Nodes / Q000473:pathology; D008206:Lymphatic Diseases / Q000175:diagnosis* / Q000276:immunology; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D012877:Skin Manifestations
D007074:Immunoglobulin G
Adénopathies angio-immunoblastiques avec anémie auto-immune et hyperimmunoglobulinémie polyclonale