Rate dependent drug effects: possible state dependency.
Of 6 rats given extensive experience responding on a fixed-interval reinforcement schedule after injections of 1 mg/kg d-amphetamine, 3 showed significant rate dependent changes in responding when presession saline was substituted for d-amphetamine. Low rates were increased and high rates decreased by the change from d-amphetamine to saline, a result commonly found when d-amphetamine is first introduced. This indicates that rate dependent changes in fixed-interval responding may be state dependent phenomena.
D000818:Animals; D003214:Conditioning, Classical / Q000187:drug effects; D003913:Dextroamphetamine / Q000494:pharmacology*; D006801:Humans; D008297:Male; D051381:Rats; D012055:Reinforcement Schedule; D019966:Substance-Related Disorders; D013997:Time Factors
D003913:Dextroamphetamine