title: [Catecholamines metabolism in extrapyramidal disorders in children].
abstract: The author examined the catecholamine metabolism in 78 children with polyetiological extrapyramidal lesions of the nervous system. Most of the cases were with the pallidnigral syndrome. A sharp drop in the catecholamine excretion, especially of the dopamine and DOPA were detected in the akinetico-rigid forms. In torsion muscular deformant dystonia there was the most expressed drop in the DOPA excretion. Under the impact of a pathogenetical treatment by L-DOPA in most of the cases there was an improvement of the clinical state and in the indices of the catecholamine metabolism. A study of the catecholamine metabolism permitted to detect certain aspects in the pathogenesis of different forms of extrapyramidal lesions in children.
mesh_terms: D000293:Adolescent; D001260:Ataxia Telangiectasia / Q000378:metabolism; D001480:Basal Ganglia Diseases / Q000378:metabolism*; D002395:Catecholamines / Q000378:metabolism*; D002648:Child; D002675:Child, Preschool; D002940:Circadian Rhythm; D004295:Dihydroxyphenylalanine / Q000378:metabolism; D004298:Dopamine / Q000652:urine; D004422:Dystonia Musculorum Deformans / Q000378:metabolism*; D004837:Epinephrine / Q000378:metabolism; D006801:Humans; D009638:Norepinephrine / Q000378:metabolism; D013577:Syndrome
chemical_list: D002395:Catecholamines; D004295:Dihydroxyphenylalanine; D004298:Dopamine; D009638:Norepinephrine; D004837:Epinephrine
vernacular_title: Obmen katekholaminov pri ékstrapiramidnykh narusheniiakh u deteĭ.