Lack of gastric effects of S-(carboxy-methyl)-L-cysteine.
In 10 male subjects, the effects of oral S-(carboxy-methyl)-L-cysteine (SCMC) -- a mucolytic agent useful in the treatment of chronic obstructive bronchitis -- on gastric secretion of acid and N-acetylneuraminic acid (NANA) containing glycoproteins were investigated. Gastric acid outputs and mucus secretory rates remained unchanged during a 10-day period of daily administration of SCMC. Thus, the receptors of SCMC in the bronchial system appear to differ basically from those in the stomach.
D002233:Carbocysteine / Q000494:pharmacology*; D003545:Cysteine / Q000031:analogs & derivatives*; D005750:Gastric Juice / Q000378:metabolism; D005752:Gastric Mucins / Q000378:metabolism; D005753:Gastric Mucosa / Q000187:drug effects* / Q000378:metabolism; D006801:Humans; D008297:Male; D012794:Sialic Acids / Q000378:metabolism
D005752:Gastric Mucins; D012794:Sialic Acids; D002233:Carbocysteine; D003545:Cysteine