Glycoprotein alterations in human colonic adenocarcinoma.
A marked diminution in membrane glycoproteins containing blood group A activity was observed in colonic cancer tissues. This change was associated with a reduction of the enzyme responsible for its biosynthesis and a decreased concentration of N-acetylgalactosamine in the cancer tissues. Glycosidase activities were unchanged. In addition to the changes associated with blood group A, we also found a decrease in sugar content, alterations in other antigens, and changes in the levels of several glycosyltransferases in cancerous tissues.
D000230:Adenocarcinoma / Q000378:metabolism*; D001789:Blood Group Antigens; D050260:Carbohydrate Metabolism; D003110:Colonic Neoplasms / Q000378:metabolism*; D006020:Glycopeptides / Q000378:metabolism; D006023:Glycoproteins / Q000096:biosynthesis*; D006026:Glycoside Hydrolases / Q000378:metabolism; D006385:Hemagglutination Inhibition Tests; D006602:Hexosyltransferases / Q000378:metabolism; D006801:Humans; D007413:Intestinal Mucosa / Q000201:enzymology
D001789:Blood Group Antigens; D006020:Glycopeptides; D006023:Glycoproteins; D006602:Hexosyltransferases; D006026:Glycoside Hydrolases