Splenectomy or radiation and splenectomy for hypersplenism in lymphosarcoma.
This is a retrospective study of 14 patients with lymphosarcoma with hypersplenism. Eight patients received radiation to the spleen followed by splenectomy for recurrence of hypersplenism. Six patients underwent primary splenectomy for hypersplenism. Radiation decreases the size of the spleen but recurrence of hypersplenism is seen in an average of 8 mo. Splenectomy in these cases improves the hematological picture. Average postsplenectomy survival is 27.6 mo. Splenectomy alone in hypersplenism also improves the hematological picture. Postsplenectomy survival in this group is 13 mo. One case of primary lymphosarcoma of the spleen is reported.
D000328:Adult; D000368:Aged; D001803:Blood Transfusion; D006801:Humans; D006971:Hypersplenism / Q000532:radiotherapy / Q000601:surgery*; D008228:Lymphoma, Non-Hodgkin / Q000150:complications* / Q000401:mortality; D008875:Middle Aged; D011183:Postoperative Complications / Q000628:therapy; D011879:Radiotherapy Dosage; D012008:Recurrence; D012189:Retrospective Studies; D013156:Splenectomy; D013921:Thrombocytopenia / Q000532:radiotherapy