Effects of ADH on the activity and function of the renin-angiotensin-aldosterone system in infants and in children.
In babies ranging in age from 1 to 25 weeks and in children between 1 and 14 years, plasma renin activity and urinary aldosterone activity were determined in relation to urinary sodium excretion. A reciprocal correlation was found demonstrating that the hyperactivity of the renin-angiotensin-aldosterone system is stimulated in infants by a low sodium intake. A second stimulus was observed in the influence of the hypothalamo-neurohypophyseal system, when the plasma renin activity was suppressed by administration of antidiuretic hormone and sodium excretion increased due to a decreased aldosterone activity. Our study suggests that there exists a feedback between the renin-angiotensin-aldosterone system and ADH release and that this feedback plays an important role in the regulation of water and electrolyte balance in the young infant.
D000293:Adolescent; D000450:Aldosterone / Q000652:urine*; D000804:Angiotensin II / Q000097:blood*; D002648:Child; D002675:Child, Preschool; D005246:Feedback; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D009318:Natriuresis; D012083:Renin / Q000097:blood*; D014667:Vasopressins / Q000502:physiology*
D014667:Vasopressins; D000804:Angiotensin II; D000450:Aldosterone; D012083:Renin