title: [Distribution of radioactive tetanus toxin at the subcellular level].
abstract: Experiments were carried out on rabbits for detecting the distribution of radioactive tetanotoxin between subcellular fractions of tissues of the central nervous system. It has been found out that a parenteral administration of tetanotoxin-35S results in a quick rise of the tissue radioactivity. The radioactivity of the free ribosome fraction remained most constant and high, which might be an indication of a high acceptory capacity of these organelles to tetanotoxin. For some periods of an acute tetanus intoxication, a rather high tropism of tetanotoxin of synaptosome, microsome and myelinic fragments was found.
mesh_terms: D000818:Animals; D002490:Central Nervous System / Q000378:metabolism / Q000648:ultrastructure*; D011817:Rabbits; D012270:Ribosomes / Q000378:metabolism; D013574:Synaptosomes / Q000378:metabolism; D013744:Tetanus Toxin / Q000378:metabolism*
chemical_list: D013744:Tetanus Toxin
vernacular_title: K voprosu o raspredelenii radioaktivnogo stolbniachnogo toksina na subkletochnom urovne.