Prevention of intraperitoneal adhesions by dextran. Hydrocortisone and chymotrypsin. An experimental study.
The purpose of an experimental study in guineapigs was to prevent adhesion formation in the intra-abdominal space by simultaneous intraperitoneal infusion of hydrocortisone, dextran and chymotrypsin. An examination made three weeks after the operation revealed a highly significant (p less than 0.001) difference in favour of the dextran, dextran-chymotrypsin and dextran-chymotrypsin-hydrocortisone groups when compared with the NaC1 and control groups.
D000818:Animals; D002918:Chymotrypsin / Q000008:administration & dosage / Q000627:therapeutic use*; D003911:Dextrans / Q000008:administration & dosage / Q000627:therapeutic use*; D004359:Drug Therapy, Combination; D006168:Guinea Pigs; D006854:Hydrocortisone / Q000008:administration & dosage / Q000627:therapeutic use*; D007274:Injections, Intraperitoneal; D008297:Male; D010532:Peritoneal Diseases / Q000517:prevention & control*; D011183:Postoperative Complications / Q000517:prevention & control*; D000267:Tissue Adhesions
D003911:Dextrans; D002918:Chymotrypsin; D006854:Hydrocortisone