Intestinal calcium-binding protein 3 months after massive small bowel resection in the piglet.
Changes in intestinal calcium-binding protein and calcium binding activity were studied at resection and 3 months after 90% small bowel resection in piglets and one adult pig. A calcium-binding protein (MW congruent to 11.000) with calcium-dependent eletrophoretic mobility was partially purified from mucosal extract of proximal jejunum, mid-gut, and ileum. The concentration of calcium-binding protein and the calcium-binding activity of the intact animals were found highest in the proximal jejunal segment, lowest in the ileal segment. After resection in the four surviving animals out of nine, a significant increase in calcium-binding activity was observed in the proximal jejunum and in the distal ileal segment. The change in calcium-binding activity was much more marked in the ileum than the jejunum. These data demonstrate that pig intestinal mucosa possesses an adaptive capacity to increase the synthesis of calcium-binding protein after massive small bowel resection.
D000222:Adaptation, Physiological; D000818:Animals; D002118:Calcium / Q000378:metabolism*; D002352:Carrier Proteins / Q000378:metabolism*; D007082:Ileum / Q000502:physiology; D007413:Intestinal Mucosa / Q000502:physiology; D007421:Intestine, Small / Q000502:physiology* / Q000601:surgery; D007583:Jejunum / Q000502:physiology; D008297:Male; D011485:Protein Binding; D013552:Swine / Q000378:metabolism*
D002352:Carrier Proteins; D002118:Calcium