title: [Postimplantation development of rat embryos following application of injurious agents to male gametes].
abstract: It was shown that in the embryos whose fathers had been subjected to x-ray irradiation, there appeared pathological alterations involving all parts of the embryo, resulting in high postimplantation mortality. In contrast to x-ray irradiation, chloridine affecting male gametes did not result in the increased embryonic death rate and disorders in embryogenesis as compared with controls. It permitted a conclusion of the process of rat spermatogenesis being resistant to this preparation.
mesh_terms: D000014:Abnormalities, Drug-Induced; D000818:Animals; D000013:Congenital Abnormalities / Q000209:etiology*; D010064:Embryo Implantation; D005260:Female; D005313:Fetal Death / Q000139:chemically induced / Q000209:etiology*; D008297:Male; D011247:Pregnancy; D011739:Pyrimethamine / Q000633:toxicity*; D011833:Radiation Injuries, Experimental / Q000235:genetics*; D051381:Rats; D013094:Spermatozoa / Q000528:radiation effects
chemical_list: D011739:Pyrimethamine
vernacular_title: Izuchenie postimplantatsionnogo razvitiia zarodysheĭ krys posle deĭstviia povredaiushchikh agentov na muzhskie gamety