title: Absorption of ampicillin derivatives from the bovine udder.
abstract: The rates at which ampicillin, amoxycillin, metampicillin, hetacillin, and pivampicillin are absorbed from the bovine udder were compared, with the absorption rate of (14C)urea as reference. Straight-line semilogarithmic plots of the percentage of unabsorbed drug against time were obtained, suggesting first-order kinetics for the absorption process. Ampicillin, metampicillin and hetacillin were most slowly absorbed. Amoxycillin was absorbed twice as fast as ampicillin. Pivampicillin was absorbed most rapidly-at more than three times the rate of ampicillin.
mesh_terms: D000658:Amoxicillin / Q000378:metabolism; D000667:Ampicillin / Q000031:analogs & derivatives* / Q000378:metabolism; D000818:Animals; D002417:Cattle; D006801:Humans; D008321:Mammary Glands, Animal / Q000378:metabolism*; D010406:Penicillins / Q000378:metabolism; D010917:Pivampicillin / Q000378:metabolism
chemical_list: D010406:Penicillins; D010917:Pivampicillin; D000667:Ampicillin; D000658:Amoxicillin