Biphasic kinetic profile for carbamazepine epoxide formation.
The formation of the stable 10,11-epoxide from carbamazepine by rat liver microsomes was studied. A biphasic activity-substrate profile was consistently found with microsomes from both control and phenobarbital pretreated rats. These data could either indicate epoxide formation by multiple catalytic sites with differential substrate affinity or a solvent effect on the enzyme or its environment.
D000818:Animals; D002220:Carbamazepine / Q000378:metabolism*; D004852:Epoxy Compounds / Q000378:metabolism; D066298:In Vitro Techniques; D007700:Kinetics; D008930:Mitochondria, Liver / Q000378:metabolism*; D051381:Rats
D004852:Epoxy Compounds; D002220:Carbamazepine