[Comparative evaluation of the action of clofeline and isoglaucon on the eye].
In experiments on rabbits it was found that the developed clofelin eyedrops in the shape of 0.125, 0.25 and 0.5 percent solutions with a rated storage time of 2 years display a hypotensive action. The fall of the intra-ocular pressure following instillation of the drug may be put down to the inhibition of the sympathetic nervous system coming as a result of the central action, as well as to the local alpha-adrenomimetic effect that brings with it a diminished secretion and improved outflow of the aqueous humor. A comparison of the effects produced by clofelin and isoglaucon on the intraocular pressure, hydro- and hemodynamics of the eyes did not reveal any essential differences between these drugs.
D000818:Animals; D003000:Clonidine / Q000494:pharmacology*; D003864:Depression, Chemical; D004305:Dose-Response Relationship, Drug; D005123:Eye / Q000187:drug effects*; D006439:Hemodynamics / Q000187:drug effects; D007429:Intraocular Pressure / Q000187:drug effects; D009883:Ophthalmic Solutions; D011817:Rabbits; D013997:Time Factors; D014065:Tonometry, Ocular
D009883:Ophthalmic Solutions; D003000:Clonidine
Sravnitel'naia otsenka deĭstviia klofelina i izoglaukona na glaz.