Influence of altered CSF solute composition on parotid salivary secretion in goats.
Infusions of hypertonic NaCl solution into the CSF of the lateral cerebral ventricle of the goat caused a marked reduction in parotid salivary flow concomitant with a rise in salivary [Na+]. Corresponding infusions of iso- or hypertonic glucose and glycerol solutions affected salivary secretion in the opposite direction. The possibility is discussed that a periventricular sodium-sensitive mechanism, which is of importance in the central control of fluid balance, also may participate in the regulation of parotid secretion in the goat. This interpretation of the results is to some extent obscured by the observation of a high incidence of intermittent rumination during the intraventricular infusions of glucose and glycerol solution.
D000818:Animals; D002555:Cerebrospinal Fluid; D005260:Female; D005947:Glucose / Q000008:administration & dosage / Q000494:pharmacology; D005990:Glycerol / Q000008:administration & dosage / Q000494:pharmacology; D006041:Goats; D007276:Injections, Intraventricular; D009994:Osmolar Concentration; D010306:Parotid Gland / Q000378:metabolism*; D011188:Potassium / Q000032:analysis; D012462:Saline Solution, Hypertonic / Q000008:administration & dosage / Q000494:pharmacology*; D012463:Saliva / Q000032:analysis / Q000378:metabolism*; D012636:Secretory Rate / Q000187:drug effects; D012964:Sodium / Q000032:analysis; D012965:Sodium Chloride / Q000494:pharmacology*; D014882:Water-Electrolyte Balance / Q000187:drug effects
D012462:Saline Solution, Hypertonic; D012965:Sodium Chloride; D012964:Sodium; D005947:Glucose; D005990:Glycerol; D011188:Potassium