The effects of antipyretics on metabolic processes in rat liver mitochondria. Part II. The action of sodium salicylate, and pyrazolones on oxidation of alpha-ketoglutarate.
The effect of sodium salicylate (SS), phenazone (Ph), and amiphenazone (APh) on the uptake of alpha-ketoglutarate (alpha-KG) by the rat liver mitochondria was studied in vitro. The investigated antipyretics inhibited the uptake of alpha-KG in the state 3 of respiration, and significantly increased it in state 4. This results and those of the preceding paper show that alpha-KG taken up by the mitochondrial preparations in respiratory state 4 is not utilized in the oxidative processes of the respiratory chain.
D000632:Aminopyrine / Q000494:pharmacology; D000700:Analgesics / Q000494:pharmacology*; D000818:Animals; D000983:Antipyrine / Q000494:pharmacology; D004140:Dinitrophenols / Q000494:pharmacology; D066298:In Vitro Techniques; D007656:Ketoglutaric Acids / Q000378:metabolism*; D008930:Mitochondria, Liver / Q000187:drug effects / Q000378:metabolism*; D010084:Oxidation-Reduction; D010101:Oxygen Consumption / Q000187:drug effects; D010710:Phosphates / Q000378:metabolism; D051381:Rats; D012459:Salicylates / Q000494:pharmacology; D013268:Stimulation, Chemical
D000700:Analgesics; D004140:Dinitrophenols; D007656:Ketoglutaric Acids; D010710:Phosphates; D012459:Salicylates; D000632:Aminopyrine; D000983:Antipyrine