Acidosis, local anesthetics, and the newborn.
Four newborn infants were studied following maternal epidural block with lidocaine or mepivacaine. Each of these neonates, born with a pH of 7.23 or below in the umbilical vein blood, showed an elevated fetal-to-maternal concentration ratio, a possible manifestation of ion trapping of a weak base.
D000138:Acidosis / Q000209:etiology*; D000767:Anesthesia, Epidural / Q000009:adverse effects; D000773:Anesthesia, Obstetrical / Q000009:adverse effects*; D005260:Female; D005312:Fetal Blood / Q000032:analysis; D005318:Fetal Heart / Q000503:physiopathology; D006801:Humans; D007231:Infant, Newborn; D007232:Infant, Newborn, Diseases / Q000209:etiology*; D008012:Lidocaine / Q000009:adverse effects; D008297:Male; D008431:Maternal-Fetal Exchange / Q000187:drug effects; D008619:Mepivacaine / Q000009:adverse effects; D008991:Monitoring, Physiologic; D011247:Pregnancy
D008012:Lidocaine; D008619:Mepivacaine