[Reversible suppression of cellular aggregation by cytochalasin B and kolkhamin].
Aggregation of normal mouse fibroblast-like cells plated on the surface of millipore filter was studied quantitatively. It was shown that addition of 10 mug/ml of cytochalasin B (a drug which blocked active cell locomotion) or 0.1 mug/ml of colcemid (a drug which destroyed polarization processes in the cells and therefore interfered with the oriented cell movement) completely inhibited such aggregation. This inhibition was reversible: after the drugs were washed off the cells did aggregate. It was concluded that cell aggregation in this experimental system required active cell movement and cell polarization.
D000818:Animals; D002449:Cell Aggregation / Q000187:drug effects*; D002478:Cells, Cultured; D003078:Colchicine / Q000494:pharmacology*; D003571:Cytochalasin B / Q000494:pharmacology*; D003864:Depression, Chemical; D051379:Mice
D003571:Cytochalasin B; D003078:Colchicine
Obratimoe podavlenie kletochnoĭ agregatsii tsitokhalazinom B i kolkhaminom