title: GLC determination of urinary chlorthalidone levels.
abstract: A sensitive and specific GLC method for the determination of urinary chlorthalidone levels was developed using on-column methylation. Chlorthalidone is converted to a tetramethylated derivative with trimethylanilinium hydroxide in methanol. This method which permits the determination of as little as 0.1 microgram of chlorthalidone/ml of dog urine, should be adequate for use with human subjects receiving a clinical dose.
mesh_terms: D000818:Animals; D002752:Chlorthalidone / Q000652:urine*; D002849:Chromatography, Gas; D004285:Dogs; D006801:Humans; D008297:Male; D013058:Mass Spectrometry; D008722:Methods
chemical_list: D002752:Chlorthalidone