[Comparison of the antitussive effect of two different drugs regarding frequency and strength of cough attacks (author's transl)].
The antitussive effect of two different drugs A (Codeine, Phenyltoloxamine) and B (Dihydrocodeine, Remedacen) was compared in a double blind clinical trial by measuring the frequency and strength of cough attacks for 7 hours. The cough attacks were measured by a pressure-monitoring device which was externally fastened to the throat. Drug B suppressed the strenght and frequency for at least 9 hours after application while the effectiveness of drug A lasted only for about 6 hours after application. In any case the respiratory drive was unaffected.
D000328:Adult; D000368:Aged; D000996:Antitussive Agents / Q000627:therapeutic use*; D001559:Benzhydryl Compounds / Q000627:therapeutic use; D003061:Codeine / Q000031:analogs & derivatives / Q000627:therapeutic use; D003371:Cough / Q000188:drug therapy*; D004341:Drug Evaluation; D005021:Ethylamines / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D013997:Time Factors
D000996:Antitussive Agents; D001559:Benzhydryl Compounds; D005021:Ethylamines; C008865:phenyltoloxamine; C014481:dihydrocodeine; D003061:Codeine
Vergleich der antitussiven Wirksamkeit von zwei verschiedenen Medikamenten bezogen auf Hustenfrequenz und -stärke.