Isolation and characterization of satellite antibiotics, mimosamycin and chlorocarcins from Streptomyces lavendulae, streptothricin source.
Under novel conditions of culture, Streptomyces lavendulae No. 314 was found to produce new antibiotics, chlorocarcins and mimosamycin in addition to streptothricin. The antibiotics are extracted from culture filtrate with organic solvents and further purified by silica gel chromatography. Chlorocarcins A, B and C are closely related basic antibiotics which are active against gram-positive bacteria, EHRLICH carcinoma and L 1210 leukemia of mice. Mimosamycin is a neutral antibiotic which is mainly active against mycobacteria. Production, isolation and physicochemical properties of the antibiotics are described.
D000818:Animals; D000900:Anti-Bacterial Agents / Q000096:biosynthesis / Q000302:isolation & purification / Q000494:pharmacology; D000903:Antibiotics, Antineoplastic / Q000627:therapeutic use; D001419:Bacteria / Q000187:drug effects; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D007939:Leukemia L1210 / Q000188:drug therapy; D051379:Mice; D009161:Mycobacterium / Q000187:drug effects; D013302:Streptomyces / Q000378:metabolism*; D013997:Time Factors
D000900:Anti-Bacterial Agents; D000903:Antibiotics, Antineoplastic