Spindle-cell tumours and hypoglycaemia.
The light microscopy and clinical features of two patients with extrapancreatic tumours and hypoglycaemic episodes are described-together with the electron microscopy findings in one patient. The primary tumour of one patient arose within the skull and later metastasized to the liver, while the other patient had a locally recurrent intrathoracic tumour. Neither the intracranial origin nor the ultrastructural features support the concept of a mesothelial origin for these tumours, and they should be referred to as spindle-cell tumours associated with hypoglycaemia. There are ultrastructural similarities between these neoplasms and those of the pancreatic beta cells.
D000328:Adult; D000368:Aged; D001921:Brain / Q000473:pathology; D001932:Brain Neoplasms / Q000150:complications*; D005260:Female; D006394:Hemangiosarcoma / Q000150:complications*; D006801:Humans; D007003:Hypoglycemia / Q000150:complications* / Q000209:etiology; D008099:Liver / Q000473:pathology; D008113:Liver Neoplasms / Q000150:complications*; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000473:pathology; D010994:Pleura / Q000648:ultrastructure; D010997:Pleural Neoplasms / Q000473:pathology*; D011247:Pregnancy; D011248:Pregnancy Complications / Q000473:pathology