Gene dosage effect in human triploid fibroblasts.
The activity of 13 cytoplasmic enzymes has been determined in fibroblast extracts from 9 triploid and 13 control lines. The results show a high activity for 2 X-linked enzymes, glucose 6-phosphate dehydrogenase and phosphoglycerate kinase. These data, together with cytogenetic observations, support the contention that 2 X chromosomes were active in the triploid lines.
D005347:Fibroblasts / Q000201:enzymology*; D005954:Glucosephosphate Dehydrogenase / Q000378:metabolism; D006801:Humans; D010641:Phenotype; D010735:Phosphoglycerate Kinase / Q000378:metabolism; D011123:Polyploidy; D012730:Sex Chromosomes
D005954:Glucosephosphate Dehydrogenase; D010735:Phosphoglycerate Kinase