title: Utilization of a low-lactose milk.
abstract: This study was undertaken to determine if a milk containing prehydrolyzed lactose, yet affording full nutritional benefits, could be ingested by a milk intolerant (MI) population without the symptoms of lactose intolerance. MI was defined by the failure of serum glucose to rise greater than 20 mg/100 ml after ingestion of 50 gm of lactose as well as by subjective and objective symptoms and signs after consumption of both 12.5 gm of lactose in water and 250 ml of skim milk. Lactose tolerance (LT) was evidenced by both lack of symptoms and a concomitant rise in serum glucose of greater than 20 mg/100 ml after ingestion of 50 gm lactose in water. A series of four, two hr tolerance tests were given to 12 MI patients and 12 LT controls. The following solutions were employed: 12.5 gm lactose, 250 ml skim milk. 250 ml low-lactose skim milk, and 6 gm glucose plus 6 gm galactose. In the MI group, significant differences were apparent between the tolerance test utilizing skim milk and that using low-lactose skim milk; no such differences were observed in the LT group. These observations indicate that in the MI population the lactose in skim milk was poorly absorbed or tolerated, but after hydrolysis the low-lactose skim milk was well tolerated. A MI individual then, appears able to absorb the monosaccharides of the prehydrolyzed milk and can, furthermore, tolerate the low-lactose skim milk without suffering from symptoms normally associated with lactose intolerance.
mesh_terms: D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D003967:Diarrhea / Q000209:etiology; D005215:Fasting; D005414:Flatulence / Q000209:etiology; D005696:Galactosidases; D005767:Gastrointestinal Diseases / Q000209:etiology; D006801:Humans; D006868:Hydrolysis; D007785:Lactose / Q000009:adverse effects / Q000032:analysis; D007787:Lactose Intolerance / Q000178:diet therapy*; D007789:Lactose Tolerance Test; D008892:Milk / Q000009:adverse effects / Q000032:analysis
chemical_list: D001786:Blood Glucose; D005696:Galactosidases; D007785:Lactose