[Effect of cardiac desympathization, stimulation of the central adrenergic structures and blockade of beta-adrenergic receptors on cardiotonic and cardiotoxic effect of cardiac glycosides].
The object of study were rabbits who had been subjected to ligation of 3 or 4 large branches of the left descending coronary artery 14-20 days before the experiment. In experiments with surgical desympathization of the heart it was established that the inotropic effect of cardiac glycosides did not depend on the concentration of catecholamines in the myocardium. In stimulation of adrenergic structures of the posterior hypothalamus attended with an increase in sympathetic innervation of the cardiovascular system the cardiotoxic threshold of cardiac glycosides was considerably reduced. Propranolol (Inderal) administered in a dose which blocks the beta-adrenergic apparatus of the heart prevents the development of the positive inotropic effect of therapeutic doses of strophanthin K on a hypodynamic left ventricular myocardium.
D000818:Animals; D001145:Arrhythmias, Cardiac / Q000139:chemically induced; D003714:Denervation; D005725:Ganglia, Autonomic / Q000601:surgery*; D006321:Heart / Q000187:drug effects* / Q000294:innervation; D007031:Hypothalamus / Q000187:drug effects*; D008297:Male; D011433:Propranolol / Q000494:pharmacology*; D011817:Rabbits; D011941:Receptors, Adrenergic / Q000187:drug effects*; D013328:Strophanthins / Q000009:adverse effects / Q000494:pharmacology*
D011941:Receptors, Adrenergic; D013328:Strophanthins; D011433:Propranolol
Vliianie desimpatizatsii serdtsa, razdrazheniia tsentral'nykh adrenergicheskikh struktur i blokady beta-adrenergicheskikh retseptorov na kardiotonicheskoe i kardiotoksicheskoe deĭstvie serdechnykh glikozidov.