[Effect of a number of sulfur-containing radioprotective agents on the evacuatory function of the stomach in mice].
Tests staged on mongrel albino mice demonstrated that sulphur-containing radioprotectors used in doses two orders below those exercising a radioprotective action with their peroral administration are apt to significantly modify the evacuative function of the stomach. This properties of the sulphur-containing radioprotectors depends upon their chemical structure. A particularly strong influence on the evacuative function of the stomach in mice exerts cystamine dichlorohydrate, aminoalkylamino-alkylthiophosphates and mercaptoamidines. This property is less pronounced in cystaphos and cysteamine chlorhydrate. The least effect on the delayed evacuation was found in cysteamine bitartrate and in the disodium salt-4, 4(1)-trithiobis (butane-sulphonate). These data allow it to explain the specificity of the toxic and radioprotective action produced by diverse drugs with their peroral administration.
D000818:Animals; D005260:Female; D005769:Gastrointestinal Motility / Q000187:drug effects*; D008297:Male; D051379:Mice; D009499:Neutral Red; D011837:Radiation-Protective Agents / Q000494:pharmacology*; D013270:Stomach / Q000187:drug effects*; D013329:Structure-Activity Relationship; D013455:Sulfur; D013997:Time Factors
D011837:Radiation-Protective Agents; D009499:Neutral Red; D013455:Sulfur
Vliianie na évakuatornuiu funksiiu zheludka mysheĭ riada sersoderzhashchikh radioprotektorov.