Influence of middle-sized molecule aggregates from dialysate of uremic patients on lymphocyte transformation in vitro.
It was found that middle-sized molecules obtained from dialysate of uremic patients caused suppression of PHA-induced lymphocyte transformation. This was expressed by the lowering of labeled leucine incorporation and by the suppression of lymphocyte transformation as morphologically assessed. In view of the presented data middle-sized molecules seem to be biologically active substances.
D037102:Lectins / Q000494:pharmacology; D008213:Lymphocyte Activation; D008970:Molecular Weight; D010316:Particle Size; D010455:Peptides / Q000494:pharmacology; D006435:Renal Dialysis; D014511:Uremia / Q000276:immunology* / Q000628:therapy
D037102:Lectins; D010455:Peptides