Renal cortical blood redistribution after bumetanide related to heterogenicity of cortical prostaglandin metabolism in dogs.
Bumetanide is shown to increase renal blood flow and to augment the proportion of the cortical blood flow to middle cortex. This redistribution still takes place even when renal blood flow is maintained constant by renal artery clamping. Indomethacin pretreatment inhibits the increase of renal blood flow as well as the cortical blood redistribution. In vitro examinations of canine kidney tissue slices suggest that outer cortex and papillar are sites of prostaglandin synthesis. No differences in prostaglandin E degradation are observed within the cortex. This suggests a relative autonomy for prostaglandins in the outer cortex, whilst inner cortical areas are dependent on medullary/papillary prostaglandin E supply. The renal hemodynamic effect of bumetanide is therefore thought to be a result of a stimulation of mainly medullary/papillary prostaglandin synthesis.
D000818:Animals; D001095:Arachidonic Acids / Q000378:metabolism; D001794:Blood Pressure / Q000187:drug effects; D002034:Bumetanide / Q000494:pharmacology*; D004231:Diuresis / Q000187:drug effects; D004232:Diuretics / Q000494:pharmacology*; D004285:Dogs; D005260:Female; D007213:Indomethacin / Q000494:pharmacology; D007672:Kidney Cortex / Q000098:blood supply* / Q000378:metabolism; D011458:Prostaglandins E / Q000096:biosynthesis / Q000378:metabolism*; D012039:Regional Blood Flow / Q000187:drug effects
D001095:Arachidonic Acids; D004232:Diuretics; D011458:Prostaglandins E; D002034:Bumetanide; D007213:Indomethacin