Prostaglandins and leucocyte migration in inflammatory reactions.
The effects of a variety of particulate irritants on the prostaglandin content, protein concentration and the leucocyte counts in the exudate of implanted inert sponges and on the development of paw oedema in the rat have been studied. Variations in prostaglandin accumulation and leucocyte migration were not related but irritants causing a long-standing paw oedema increased both parameters.
D000818:Animals; D001798:Blood Proteins / Q000378:metabolism; D002351:Carrageenan / Q000494:pharmacology; D002465:Cell Movement; D005260:Female; D007249:Inflammation / Q000503:physiopathology*; D007509:Irritants / Q000494:pharmacology; D007962:Leukocytes / Q000502:physiology*; D011453:Prostaglandins / Q000378:metabolism*; D051381:Rats; D013997:Time Factors; D015054:Zymosan / Q000494:pharmacology
D001798:Blood Proteins; D007509:Irritants; D011453:Prostaglandins; D002351:Carrageenan; D015054:Zymosan