title: Intolerance to aspirin: clinical and immunological studies.
abstract: Skin-tests, patch-tests, Prausnitz-Küstner reactions, passive cutaneous anaphylaxis in guinea pigs according to Ovary and lymphocyte proliferation tests in vitro using thymidine 2-C14 have been carried out in 31 patients with aspirin intolerance. Acetylsalicyclic acid, aspiryl-polylysine, lysine acetylsalicylate, and sodium salicylate were used in these investigations. Collagen-induced platelet aggregation according to BORN in the presence of aspirin was also studied. An immunological mechanism was revealed in only a small percentage of the patients studied, indicating in the remaining cases the possible role of nonimmunological processes or the inadequacy of the test technique employed.
mesh_terms: D000293:Adolescent; D000328:Adult; D001241:Aspirin / Q000276:immunology* / Q000494:pharmacology; D001249:Asthma / Q000276:immunology; D002648:Child; D004247:DNA / Q000096:biosynthesis; D004342:Drug Hypersensitivity; D005260:Female; D006801:Humans; D008239:Lysine; D008297:Male; D008875:Middle Aged; D009298:Nasal Polyps / Q000276:immunology; D010085:Oxidative Phosphorylation / Q000187:drug effects; D010101:Oxygen Consumption / Q000187:drug effects; D010974:Platelet Aggregation / Q000187:drug effects; D012980:Sodium Salicylate / Q000276:immunology
chemical_list: D004247:DNA; D008239:Lysine; D001241:Aspirin; D012980:Sodium Salicylate