Prostaglandin-induced diarrhoea.
A child with chronic diarrhoea since birth responded to the prostaglandin synthetase inhibitors aspirin and indomethacin. During a period without treatment, raised levels of prostaglandins F2alpha and E2 were observed. No source for these raised prostaglandins was shown, and it is suggested that she may have an inborn defect of prostaglandin metabolism.
D001241:Aspirin / Q000627:therapeutic use; D002675:Child, Preschool; D003967:Diarrhea / Q000188:drug therapy / Q000209:etiology* / Q000378:metabolism; D005260:Female; D006801:Humans; D007213:Indomethacin / Q000627:therapeutic use; D011453:Prostaglandins / Q000097:blood / Q000378:metabolism*
D011453:Prostaglandins; D001241:Aspirin; D007213:Indomethacin