title: [Transport RNA in early embryogenesis of fish. 3. Certain problems of regulation of RNA synthesis at the early stages of development of the loach (Misgurnus fossilis (1)].
abstract: tRNA synthesis in the early loach embryos of different ploidy and factors of the activation of synthesis and the maturation of tRNA molecules at the mid-blastula stage have been studied. tRNA synthesis is activated at the early- and mid-blastula and in the beginning of gastrulation. The normal activation of synthesis and maturation of tRNA molecules require the embryo to be maintained in the contact with the yolk at the earlier developmental stages. The methionine starvation may be one of the factors limiting the rate of tRNA maturation. The activity of tRNA synthesis during blastulation was shown to depend on gene dosage. At this stage the paternal and maternal tRNA genes are transcribed independently. In the beginning of gastrulation, the type of tRNA synthesis control markedly changes and the effect of gene dose compensation manifests itself, that is typical for the control of rRNA synthesis as well. The data obtained are discussed with respect to the state of protein synthesizing system at the moment of activation of specific protein syntheses with the onset of morphogenesis.
mesh_terms: D000818:Animals; D001756:Blastoderm / Q000378:metabolism; D004171:Diploidy; D004625:Embryo, Nonmammalian / Q000378:metabolism*; D005260:Female; D005399:Fishes / Q000196:embryology*; D005809:Genes, Regulator; D006238:Haploidy; D008297:Male; D009024:Morphogenesis; D012313:RNA / Q000096:biosynthesis*; D013997:Time Factors; D014158:Transcription, Genetic
chemical_list: D012313:RNA
vernacular_title: Transportnye RNK v rannem embriogeneze ryb. Soobshchenie 3. Nekotorye voprosy reguliatsii sinteza tRNK na rannykh stadiiakh razvitiia Bìuna Misgurnus fossilis (1)