[The effect of uncouplers of oxidative phosphorylation on granule precipitation of neutral red in normal and tumor cells].
A study of the effect of uncouplers of the oxidative phosphorylation on the interaction on neutral red with the normal mouse fibroblast and tumour L-cells showed the former to retain the capacity for the dye granule formation in the presence of 1x10 4 M 2,4-dinitrophenol (DNP). Another uncoupler of the oxidative phosphorylation - n-trifluoromethoxycarbonycyanidephenylhydrazone (FCCP) depressed the granule formation both in the tumour L-cells and in the mouse normal fibroblasts. The dye uptake in the normal fibroblasts and in the tumour L-cells was inhibited by both the DNP and the FCCR in the concentration which uncoupled the oxidative phosphorylation.
D000818:Animals; D002259:Carbonyl Cyanide p-Trifluoromethoxyphenylhydrazone / Q000031:analogs & derivatives* / Q000494:pharmacology; D003864:Depression, Chemical; D004140:Dinitrophenols / Q000494:pharmacology*; D005347:Fibroblasts / Q000187:drug effects / Q000378:metabolism; D006651:Histocytochemistry; D007739:L Cells / Q000187:drug effects* / Q000378:metabolism; D051379:Mice; D009499:Neutral Red / Q000378:metabolism*; D009570:Nitriles / Q000031:analogs & derivatives*; D010085:Oxidative Phosphorylation; D010619:Phenazines / Q000378:metabolism*
D004140:Dinitrophenols; D009570:Nitriles; D010619:Phenazines; D009499:Neutral Red; D002259:Carbonyl Cyanide p-Trifluoromethoxyphenylhydrazone
Vliianie razobshchiteleĭ okislitel'nogo fosforilirovaniia na granulootlozhenie neitral'nogo krasnogo v normal'nykh i opukholevykh kletkakh