Effect of norleucine on mycelial fragmentation in Cephalosporium acremonium.
DL-Norleucine, which is known to replace methionine for stimulation of cephalosporin C formation, also mimics methionine's effect on arthrospore formation. Thus, hyphal fragmentation, like antibiotic biosynthesis, is divorced from a sulfur donation role.
D000164:Acremonium / Q000254:growth & development* / Q000378:metabolism; D000614:Aminocaproates / Q000494:pharmacology*; D002511:Cephalosporins / Q000096:biosynthesis; D008715:Methionine / Q000494:pharmacology; D009646:Norleucine / Q000494:pharmacology*; D013172:Spores, Fungal / Q000254:growth & development / Q000378:metabolism; D013237:Stereoisomerism; D013455:Sulfur / Q000378:metabolism
D000614:Aminocaproates; D002511:Cephalosporins; D013455:Sulfur; D009646:Norleucine; D008715:Methionine