title: Partition coefficients of selected pyridine carbamates and comparisons with their acetylcholinesterase and butyrylcholinesterase inhibitory potencies.
abstract: Partition coefficients of a series of 2-substituted 3-(N,N-dimethyl)carbamyloxypyridines were determined in an octanol-buffer (pH 7.4) system. The values obtained were compared with the ihnibitory potencies of acetylcholinesterase and butyrylcholinesterase. No significant difference was found for the role of hydrophobicity in the two enzyme systems.
mesh_terms: D002219:Carbamates / Q000494:pharmacology; D055598:Chemical Phenomena; D002621:Chemistry; D002800:Cholinesterase Inhibitors; D011725:Pyridines / Q000494:pharmacology; D012995:Solubility
chemical_list: D002219:Carbamates; D002800:Cholinesterase Inhibitors; D011725:Pyridines