Teratogenicity of cytochalasin D in the mouse.
Cytochalasin D, a mold metabolite identified in food, was injected intraperitoneally in doses of 0.4 to 0.9 mg per kilogram on gestational days 7 through 11 and produced evidence of teratogenicity in two out of three strains of mice. Exencephaly, hypognathia and axial skeletal defects were found in strains C57BL/6J and BALB/c while no increase in defects was observed in the Swiss Webster strain. In all three strains, a significantly increased resorption rate was found. Oral doses of approximately 7.0 mg per kg on days 7 through 11 in the BALB/c produced exencephaly in the offspring. Autoclaved cytochalasin D retained its teratogenic potential.
D000014:Abnormalities, Drug-Induced; D000015:Abnormalities, Multiple / Q000139:chemically induced*; D009008:Abnormalities, Severe Teratoid / Q000139:chemically induced; D000818:Animals; D000853:Anophthalmos / Q000139:chemically induced; D001842:Bone and Bones / Q000002:abnormalities; D001921:Brain / Q000002:abnormalities; D002972:Cleft Palate / Q000139:chemically induced; D003572:Cytochalasins / Q000008:administration & dosage / Q000009:adverse effects*; D005260:Female; D006554:Hernia, Umbilical / Q000139:chemically induced; D007274:Injections, Intraperitoneal; D007668:Kidney / Q000002:abnormalities; D008431:Maternal-Fetal Exchange; D051379:Mice; D011247:Pregnancy
D003572:Cytochalasins