[Complex compounds with lipids in the evolution of metalloenzymes].
The change of the role of metals in the evolution of enzymes was going on from the formation by them first of labile compounds during activation by ions of various reactions to the formation of more stable complexes in active centres. During the transition from anaerobiosis to aerobiosis in oxidoreductases with the participation of metals an increase of the oxidationreduction potential values (E'O) occurred. A simultaneous accomplishment of reactions in the cells at strongly differing values of the potential became possible owing to the formation of complexes with lipids by metalloenzymes being active at high E'O. Entering the membranes of subcellular structures these metalloenzymes form complex compounds with various groups of lipids-phospholipids neutral lipids, glycolipids. These are compounds with Fe, Ti, Cu, Mn and other polyvalent metals; they regulate the transfer of electrons and its changes in the evolution of the main fermentative processes of living cells, as for example respiration and assimilation of carbon dioxide.
D000818:Animals; D005075:Biological Evolution; D055598:Chemical Phenomena; D002621:Chemistry; D004798:Enzymes; D008055:Lipids; D008670:Metals
D004798:Enzymes; D008055:Lipids; D008670:Metals
Kompleksnye soedineniia s lipidami v évoliutsii metallofermenotov