title: Symptoms and immunology of the Henoch-Schönlein-syndrome.
abstract: The Henoch-Schönlein-syndrome, or anaphylactoid purpura, is usually a childhood disease. The progess of this syndrome in adults was observed in 4 cases at our clinic. An elevated IgA level in the serum with a normal complement value seems to be of immunological interest. By immunohistological methods fibrin and IgA could be demonstrated in skin and kidney biopsies; in glomerulae C3c was observed, occasionally accompanied by Properdin-factor-B. These findings differentiate this disease from other allergic superficial vasculitids by the detection of IgG and complement; while at the same time some similarities are indicated to the so called "Berger Nephritis" with comparable kidney findings.
mesh_terms: D000328:Adult; D000368:Aged; D001808:Blood Vessels / Q000276:immunology / Q000473:pathology; D003165:Complement System Proteins / Q000032:analysis; D005260:Female; D005337:Fibrin / Q000032:analysis; D006801:Humans; D011695:IgA Vasculitis / Q000276:immunology* / Q000473:pathology; D007136:Immunoglobulins / Q000032:analysis; D007678:Kidney Glomerulus / Q000276:immunology / Q000473:pathology; D008297:Male; D011414:Properdin / Q000032:analysis; D012867:Skin / Q000098:blood supply
chemical_list: D007136:Immunoglobulins; D011414:Properdin; D005337:Fibrin; D003165:Complement System Proteins