title: Treatment of digitalis intoxication by charcoal hemoperfusion (CHP).
abstract: In the present communication, we demonstrate the removal of digoxin both in vitro and in vivo from digoxin intoxicated dogs by use of hemoperfusion over activated charcoal. In vitro drug removal was 33 ml/min at mean blood flow rates of 160 ml/min. By 30 mins of in vitro perfusion 51% of drug was removed from the reservoir and by 2 1/2 hrs 83%. In vivo clearance in dogs was 55 ml/min at blood flow rates of 150 ml/min. In view of the poor success that has been encountered in the treatment of digoxin intoxication with other modalities, charcoal hemoperfusion may represent an effective method of rapid digoxin removal from blood.
mesh_terms: D000818:Animals; D001769:Blood; D002606:Charcoal; D004071:Digitalis Glycosides / Q000506:poisoning*; D004074:Digitoxin / Q000506:poisoning; D004077:Digoxin / Q000097:blood; D004285:Dogs; D010477:Perfusion
chemical_list: D004071:Digitalis Glycosides; D002606:Charcoal; D004077:Digoxin; D004074:Digitoxin