[The extrathyroid effect of methylmercaptoimidazole. The effect of methylmercaptoimidazole on the isoenzyme distribution of tissue aspartate transaminase in thyroidectomized guinea pigs].
Administration of methylmercaptoimidazol to thyroidectomized guinea pigs decreased the activity and altered the isoenzymatic distribution of aspartic transaminase in the liver, myocardium and the brain tissue. The activity of the isoenzyme of the cytoplasm fell in all the three tissues under study. The activity of the isoenzyme of the mitochondria decreased in the liver, remained unchanged in the myocardium and increased in the brain tissue. The detected changes are associated with the direct action of methylmercaptoimidazol on the level of soluble cell proteins and on the energic metabolism in the mitochondria.
D000818:Animals; D001219:Aspartate Aminotransferases / Q000378:metabolism*; D001921:Brain / Q000201:enzymology; D006168:Guinea Pigs; D007093:Imidazoles / Q000494:pharmacology*; D007527:Isoenzymes / Q000378:metabolism*; D008099:Liver / Q000201:enzymology; D008928:Mitochondria / Q000201:enzymology; D009206:Myocardium / Q000201:enzymology; D013438:Sulfhydryl Compounds / Q000494:pharmacology*; D013965:Thyroidectomy
D007093:Imidazoles; D007527:Isoenzymes; D013438:Sulfhydryl Compounds; D001219:Aspartate Aminotransferases
Ekstratireoidnyi éffekt metilmerkaptoimidazola. Vliianie metilmerkaptoimidazola na izofermentnoe raspredelenie tkanevoĭ aspartat-transaminazy u tireoidéktomirovannykh morskikh svinok