title: Effects of nicotinic acid on plasma volume loss of experimental dysbarism.
abstract: Two groups of dogs anesthetized with sodium pentobarbital were subjected to compression of 60 psig for 60 min and decompressed at the rate of 10 psi/min without staging. Plasma volume was measured in each group by I131-tagged albumin dilution technique prior to compression, 10 min and 60 min after decompression. One group of animals received no other treatment and the other group received 15 mg/kg of body weight of nicotinic acid by intravenous injection immediately prior to compression and an additional 7.5 mg/kg of body weight of nicotinic acid 30 min after decompression. Both the untreated and the nicotinic acid-treated animals lost significant plasma volume at both the 10- and 60-min postdecompression measurements. Nicotinic acid-treated animals lost significantly less plasma.
mesh_terms: D000818:Animals; D003665:Decompression Sickness / Q000097:blood*; D004195:Disease Models, Animal; D004285:Dogs; D004341:Drug Evaluation; D009539:Nicotinic Acids / Q000494:pharmacology*; D010953:Plasma Volume / Q000187:drug effects*; D011453:Prostaglandins / Q000494:pharmacology
chemical_list: D009539:Nicotinic Acids; D011453:Prostaglandins