An in vivo stathmokinetic study of cell proliferation in human gastric carcinoma and gastric mucosa.
Cell production rates were studied in a group of eleven patients with carcinoma of the stomach using an in vivo technique with vincristine. In normal pyloric mucosa estimates ranged from 8 to 15 cells/1000 cells/hr, and in the carcinomas from 3 to 24 cells/1000 cells/hr. Because of the very large variation in the data, comparison between individual tumours and normal mucosa is not regarded as being worth-while at this stage. The implications of these results for previous human in vivo stathmokinetic experiments are also discussed.
D000230:Adenocarcinoma / Q000378:metabolism / Q000473:pathology*; D001706:Biopsy; D002453:Cell Cycle / Q000187:drug effects; D005753:Gastric Mucosa / Q000166:cytology* / Q000378:metabolism; D006801:Humans; D007700:Kinetics; D008940:Mitotic Index; D013274:Stomach Neoplasms / Q000378:metabolism / Q000473:pathology*; D014750:Vincristine / Q000008:administration & dosage / Q000494:pharmacology*
D014750:Vincristine