A new antifungal antibiotic, trichostatin.
A new antibiotic, trichostatin, was isolated from the metabolites of strains of Streptomyces hygroscopicus. It is active against trichophytons and some fungi. The structure was determined to be a derivative of a primary hydroxamic acid by chemical and spectroscopic evidences.
D000107:Acetylation; D000935:Antifungal Agents / Q000096:biosynthesis / Q000302:isolation & purification / Q000494:pharmacology; D055598:Chemical Phenomena; D002621:Chemistry; D005658:Fungi / Q000187:drug effects; D006877:Hydroxamic Acids / Q000032:analysis / Q000302:isolation & purification; D013302:Streptomyces / Q000378:metabolism
D000935:Antifungal Agents; D006877:Hydroxamic Acids