title: The effect of some glucocorticoids on hepatic microsomal hydroxylation in the rat and hamster.
abstract: The effect of some glucocorticoids on hepatic microsomal biphenyl and aniline hydroxylations were investigated in rat and hamster. Steroids were either added to the standard incubation mixture or given as a single dose intraperitoneally before preparation of the liver microsomes for enzyme determination. The addition of steroids in vitro enhanced biphenyl-2-hydroxylation activity in hepatic microsomes of rat but not of hamster and the most pronounced effect was obtained with betamethasone. A similar species difference in the effects of betamethasone on this enzyme was also observed after administration of a single dose of the steroid in vivo.
mesh_terms: D000815:Aniline Hydroxylase / Q000378:metabolism; D000818:Animals; D001189:Aryl Hydrocarbon Hydroxylases / Q000378:metabolism; D001623:Betamethasone / Q000494:pharmacology; D001713:Biphenyl Compounds / Q000378:metabolism; D006224:Cricetinae; D005938:Glucocorticoids / Q000494:pharmacology*; D006900:Hydroxylation; D008297:Male; D008862:Microsomes, Liver / Q000187:drug effects* / Q000201:enzymology / Q000378:metabolism*; D051381:Rats
chemical_list: D001713:Biphenyl Compounds; D005938:Glucocorticoids; D001623:Betamethasone; D000815:Aniline Hydroxylase; D001189:Aryl Hydrocarbon Hydroxylases