Pleuromutilins. Fermentation, structure and biosynthesis.
Derivatives of pleuromutilin, formed during the fermentation of pleuromutilin, were isolated and their structure determined. 14-Acetyl-mutilin and mutilin as well as different unsaturated fatty acid esters of pleuromutilin were identified. The proportion of each derivative formed depends to a considerable degree on the conditions of the fermentation process. The possible biosynthetic pathways are shown.
D000363:Agaricales / Q000378:metabolism; D000900:Anti-Bacterial Agents / Q000032:analysis / Q000096:biosynthesis* / Q000302:isolation & purification; D055598:Chemical Phenomena; D002621:Chemistry; D002855:Chromatography, Thin Layer; D004224:Diterpenes / Q000032:analysis / Q000096:biosynthesis* / Q000302:isolation & purification; D005285:Fermentation; D011083:Polycyclic Compounds; D013997:Time Factors; D000097567:Pleuromutilins
D000900:Anti-Bacterial Agents; D004224:Diterpenes; D011083:Polycyclic Compounds; D000097567:Pleuromutilins