title: Maximal bioavailability of digoxin from tablets and oral solution in steady state.
abstract: Comparison has been made between the absorption of digoxin from Lanoxin tablets and the absorption of international chemical reference substance digoxin from an oral solution. Plasma levels, areas under 24-hour plasma concentration curves and urinary excretion were similar by both formulations in steady state. 78% of the digoxin administered was absorbed from the tablets and 76% from the solution. Rapid dissolution in the intestinal fluids accounts for the high digoxin bioavailability of the tablets.
mesh_terms: D000328:Adult; D001682:Biological Availability; D004077:Digoxin / Q000008:administration & dosage / Q000097:blood / Q000378:metabolism*; D006801:Humans; D008875:Middle Aged; D012996:Solutions; D013607:Tablets
chemical_list: D012996:Solutions; D013607:Tablets; D004077:Digoxin