A soluble mepartricin complex (SPA-S-222) of potential oral and parenteral utility in fungal and protozoal infections.
Acute toxicity and absorption data of a soluble complex of mepartricin with sodium laurylsulphate (SPA-S-222) active against C. albicans and T. vaginalis are reported. The results demonstrate an improved bioavailability with respect to the insoluble substance. Preliminary clinical trials proved the good tolerance of the substance and its effectiveness in oral treatment of vaginal trichomoniasis.
D000284:Administration, Oral; D000818:Animals; D002181:Candidiasis, Vulvovaginal / Q000188:drug therapy*; D004357:Drug Synergism; D005260:Female; D007275:Injections, Intravenous; D008613:Mepartricin / Q000008:administration & dosage / Q000031:analogs & derivatives / Q000627:therapeutic use* / Q000633:toxicity; D051379:Mice; D011090:Polyenes / Q000627:therapeutic use*; D011817:Rabbits; D051381:Rats; D012967:Sodium Dodecyl Sulfate; D014247:Trichomonas Vaginitis / Q000188:drug therapy*
D011090:Polyenes; D008613:Mepartricin; D012967:Sodium Dodecyl Sulfate