Immune complexes in chronic hepatitis.
Rheumatoid factors were present in 33.2%, crioglobulins in 47.6%, and anticomplementary assay in 34.2% of cases with chronic active hepatitis. No statistically significant loss of total complement was observed, but its components especially C1 and C3, exhibited lowered titers in 48.6% and respectively 45.7% of 160 cases. The origin, significance and pathogenicity of these factors are discussed in connection with the presence and possible role of the immunologic complexes to the development of chronic liver injury.
D000936:Antigen-Antibody Complex; D002908:Chronic Disease; D003169:Complement Inactivator Proteins; D003165:Complement System Proteins / Q000032:analysis; D003450:Cryoglobulins / Q000032:analysis; D006505:Hepatitis / Q000276:immunology*; D006801:Humans; D012217:Rheumatoid Factor / Q000032:analysis
D000936:Antigen-Antibody Complex; D003169:Complement Inactivator Proteins; D003450:Cryoglobulins; D003165:Complement System Proteins; D012217:Rheumatoid Factor