The excretion and distribution of inorganic mercury in the rat as influenced by several chelating agents.
Among 15 chelating agents tested, sodium-2,3-dimercaptopropane 1 sulfonate (DMPS), 2,3-dimercaptopropanol (BAL), sodium-mercaptoethyliminodiacetate (MEIDA), and D-penicillamine (PA) exerted an influence on the excretion of Hg and its distribution in the organs. The excretion pattern however, is different for these compounds, and, from the practical point of view, a favourable effect is exhibited only by DMPS which enhances the urinary excretion rate and lowers the Hg-concentration in all organs.
D000818:Animals; D002614:Chelating Agents / Q000627:therapeutic use*; D004112:Dimercaprol / Q000627:therapeutic use; D004195:Disease Models, Animal; D005243:Feces / Q000032:analysis; D007668:Kidney / Q000378:metabolism; D008024:Ligands / Q000627:therapeutic use; D008297:Male; D008628:Mercury / Q000378:metabolism / Q000652:urine; D008630:Mercury Poisoning / Q000188:drug therapy*; D010396:Penicillamine / Q000627:therapeutic use; D051381:Rats; D013438:Sulfhydryl Compounds / Q000627:therapeutic use
D002614:Chelating Agents; D008024:Ligands; D013438:Sulfhydryl Compounds; D004112:Dimercaprol; D008628:Mercury; D010396:Penicillamine