title: [Effect of dextran of 250.000 molecular weight on experimental cholesterin-sclerosis in rabbits].
abstract: Effect of dextran of 250000 molecular weight on experimental cholesterin-sclerosis of rabbits was studied. Doses of 120 (mg/week) kg and 1200 (mg/week) kg administered during 12 weeks have resulted a protective effect. When doses of 1200 (mg/week) kg have been administered--in the aortic adventitia intensive cellular reaction, no hitherto described was revealed, which was considered to be a sing of the exhaustion of RES. This publication authors regard as a preliminary one. To clear whether the cellular reaction observed is a dextran-specific or macro-moleculespecific one further investigations are needed.
mesh_terms: D000818:Animals; D000924:Anticholesteremic Agents; D001161:Arteriosclerosis / Q000139:chemically induced* / Q000517:prevention & control; D002784:Cholesterol / Q000008:administration & dosage*; D003911:Dextrans / Q000008:administration & dosage / Q000494:pharmacology*; D004036:Diet, Atherogenic; D008970:Molecular Weight; D011817:Rabbits
chemical_list: D000924:Anticholesteremic Agents; D003911:Dextrans; D002784:Cholesterol
vernacular_title: 250000 molekulasúlyú dextran hatása nyulak kísérletes cholesterinsclerosisára