Effect of cytostatic agents on salivary gland tissue of the rat. The influence of 5-fluorouracil.
Application of 5-fluorouracil (5FU) for 3 weeks considerably decreased submaxillary gland weight but had no apparent influence on amylase and protein concentrations in gland extracts and isoamylase distribution patterns as revealed by electrophoresis. After another 3 weeks during which no 5FU was administered, an overproduction of protein synthesis (especially amylase) was observed.
D000818:Animals; D005260:Female; D005472:Fluorouracil / Q000494:pharmacology*; D007517:Isoamylase / Q000378:metabolism; D009929:Organ Size / Q000187:drug effects; D014176:Protein Biosynthesis; D051381:Rats; D012469:Salivary Glands / Q000033:anatomy & histology / Q000187:drug effects* / Q000378:metabolism; D013268:Stimulation, Chemical
D007517:Isoamylase; D005472:Fluorouracil