Effects of 6-aminochrysene on liver microsomal enzyme activity.
1. No transformation of 6-aminochrysene took place during its incubation with rat liver microsomes under oxygen or anaerobic conditions. 2. 6-Aminochrysene inhibited the hydroxylation of aniline, O-demethylation of p-nitroanisole, and N-demethylation of aminopyrine by rat liver microsomes. 3. Pre-treatment of rats with 6-aminochrysene markedly decreased the N-demethylation in vitro but significantly increased the hydroxylation and the O-demethylation. Similar effects were observed also with microsomal preparations from livers perfused with 6-aminochrysene.
D000633:Aminopyrine N-Demethylase / Q000378:metabolism*; D000815:Aniline Hydroxylase / Q000378:metabolism*; D000818:Animals; D008099:Liver / Q000201:enzymology; D008297:Male; D008862:Microsomes, Liver / Q000187:drug effects / Q000201:enzymology*; D006899:Mixed Function Oxygenases / Q000378:metabolism*; D010089:Oxidoreductases, N-Demethylating / Q000378:metabolism*; D010477:Perfusion; D010616:Phenanthrenes / Q000494:pharmacology*; D051381:Rats
D010616:Phenanthrenes; D006899:Mixed Function Oxygenases; D000815:Aniline Hydroxylase; D010089:Oxidoreductases, N-Demethylating; D000633:Aminopyrine N-Demethylase