The importance of angiotensin II formation in the CNS in angiostensin I - elicited thirst.
The drinking response produced by direct injection of angiotensin I and II into the brain of the rat, was studied, using the angiotensin blocking agents SQ-20,881 (SQ) and P-113 (Saralasin). SQ inhibits angiotensin converting enzyme, preventing formation of angiotensin II, while P-113 is an analogue and competitive inhibitor of angiotensin II. SQ blocked central angiotensin I drinking, but only when the enzyme inhibitor was injected into the ventricle. Angiotensin II induced thirst was not blocked by SQ. P-113 inhibited angiotensin I and II drinking responses in both the preoptic area of the hypothalamus and the lateral ventricle. These data indicate that conversion of angiotensin I to angiotensin II is important in angiotensin-induced drinking, although an independent action of angiotensin I on drinking can not be ruled out at this time.
D000804:Angiotensin II / Q000096:biosynthesis* / Q000494:pharmacology*; D000818:Animals; D001921:Brain / Q000378:metabolism*; D003864:Depression, Chemical; D004327:Drinking Behavior / Q000187:drug effects; D007031:Hypothalamus; D007267:Injections; D007276:Injections, Intraventricular; D008297:Male; D051381:Rats; D012504:Saralasin / Q000494:pharmacology; D013722:Teprotide / Q000008:administration & dosage / Q000494:pharmacology; D013894:Thirst / Q000187:drug effects*
D000804:Angiotensin II; D013722:Teprotide; D012504:Saralasin