Hemoglobin QIndia, alpha 64 (E13) Asp replaced by His, and beta-thalassemia in a Canadian family.
Cellulose acetate electrophoresis at pH 8.4 showed a hemoglobin variant with the mobility of hemoglobin S in a Canadian family. Sequence analysis revealed that histidine was substituted for aspartic acid at position 64 in the alpha-chain. This variant was found in association with a beta-thalassemia trait condition.
D000596:Amino Acids / Q000032:analysis; D002675:Child, Preschool; D006455:Hemoglobins, Abnormal / Q000032:analysis*; D006801:Humans; D007194:India; D008297:Male; D013789:Thalassemia / Q000097:blood* / Q000235:genetics
D000596:Amino Acids; D006455:Hemoglobins, Abnormal