A30641, a new epidithiodiketopiperazine with antifungal activity.
A new antibiotic, designated A30641, having in vitro activity against Gram-positive bacteria and fungi has been isolated from a strain of Aspergillus tamarii. Chemical and physical characterization indicate that it is a member of the class of antibiotics containing the epidithiodiketopiperazine moiety.
D000818:Animals; D000935:Antifungal Agents / Q000032:analysis / Q000096:biosynthesis / Q000494:pharmacology; D001230:Aspergillus / Q000378:metabolism; D001419:Bacteria / Q000187:drug effects; D005658:Fungi / Q000187:drug effects; D007928:Lethal Dose 50; D051379:Mice; D010879:Piperazines / Q000096:biosynthesis / Q000378:metabolism / Q000494:pharmacology
D000935:Antifungal Agents; D010879:Piperazines