[Effect of cerebrosides on the oxidative phosphorylation and translocation of hydrogen ions in the brain and liver mitochondria of rats].
Oxidative phosphorylation and translocation of hydrogen ions in the brain and liver mitochondria of albino rats were studied as affected by cerebrosides with their chronic intraperitoneal injection. Cerebrosides are shown to inhibit the rate of respiration in the brain and liver mitochondria with the presence of ADP as well as that of substrate respiration in the liver mitochondria. A decrease in the phosphorylation rate is observed in the brain and liver mitochondria. When studying kinetics of hydrogen ions translocation in the brain and liver mitochondria it was found out that fixation of hydrogen ions induced by ADP is unchanged quantitatively though the fixation time is prolonged. Release of hydrogen ions under the effect of CaCl2 decreases in the liver mitochondria.
D000244:Adenosine Diphosphate / Q000378:metabolism; D000818:Animals; D001667:Binding, Competitive / Q000187:drug effects; D001692:Biological Transport / Q000187:drug effects*; D001921:Brain / Q000378:metabolism / Q000648:ultrastructure*; D002122:Calcium Chloride / Q000494:pharmacology; D002417:Cattle; D002554:Cerebrosides / Q000494:pharmacology*; D006859:Hydrogen / Q000378:metabolism*; D007700:Kinetics; D008099:Liver / Q000378:metabolism; D008297:Male; D008928:Mitochondria / Q000187:drug effects*; D008930:Mitochondria, Liver / Q000187:drug effects*; D010085:Oxidative Phosphorylation / Q000187:drug effects*; D051381:Rats; D013997:Time Factors
D002554:Cerebrosides; D000244:Adenosine Diphosphate; D006859:Hydrogen; D002122:Calcium Chloride
Vliiani tserebrotsidov na okislitel'noe fosforilirovanie i translokatsiiu ionov vodoroda v mitokhondriiakh mozga i pecheni krys