Absorption of ampicillin derivatives from the bovine udder.
The rates at which ampicillin, amoxycillin, metampicillin, hetacillin, and pivampicillin are absorbed from the bovine udder were compared, with the absorption rate of (14C)urea as reference. Straight-line semilogarithmic plots of the percentage of unabsorbed drug against time were obtained, suggesting first-order kinetics for the absorption process. Ampicillin, metampicillin and hetacillin were most slowly absorbed. Amoxycillin was absorbed twice as fast as ampicillin. Pivampicillin was absorbed most rapidly-at more than three times the rate of ampicillin.
D000658:Amoxicillin / Q000378:metabolism; D000667:Ampicillin / Q000031:analogs & derivatives* / Q000378:metabolism; D000818:Animals; D002417:Cattle; D006801:Humans; D008321:Mammary Glands, Animal / Q000378:metabolism*; D010406:Penicillins / Q000378:metabolism; D010917:Pivampicillin / Q000378:metabolism
D010406:Penicillins; D010917:Pivampicillin; D000667:Ampicillin; D000658:Amoxicillin