Biliary metabolites of estriol in the rat.
Following the subcutaneous administration of estriol-6,7-3H to rats, biliary metabolites were identified and quantitated. Approximately 70% of the metabolites were excreted in the form of "glucosiduronate" conjugates. 3,17beta-Dihydroxy-2-methoxy-1,3,5(10)-estratrien-16-one was the major metabolite in this conjugate fraction. Significant amounts of 3,17beta-dihydroxy-1,3,5(10)-estratrien-16-one and 2,3,17beta-trihydroxy-1,3,5(10)-estratrien-16-one, as well as smaller quantities of 1,3,5(10)-estratriene-2,316alpha,17beta, tetrol and 2-methoxy-1,3,5(10)-estratriene-3, 16alpha, 17beta-triol, were also found. In 17alpha-ethinylestradiol-treated animals, the rate of excretion of radioactivity and the proportion of 16-oxo-17beta-ol metabolites found in the "glucosiduronate" fraction were reduced.
D000818:Animals; D001646:Bile / Q000032:analysis / Q000378:metabolism*; D004964:Estriol / Q000378:metabolism*; D004997:Ethinyl Estradiol / Q000378:metabolism; D005260:Female; D005965:Glucuronates / Q000378:metabolism; D051381:Rats; D013431:Sulfates / Q000378:metabolism; D013997:Time Factors
D005965:Glucuronates; D013431:Sulfates; D004997:Ethinyl Estradiol; D004964:Estriol