Hypertrophic osteoarthropathy and rheumatoid arthritis: simultaneous occurrence in association with diffuse interstitial fibrosis.
A patient is described who was treated with high-dose prednisone in an attempt to halt progressive respiratory insufficiency associated with diffuse interstitial fibrosis. On cessation of steroid therapy the patient was noted to have radiologic manifestations of hypertrophic osteoarthropathy (HOA) as well as clinical and laboratory features of rheumatoid arthritis (RA). Subsequently a diffuse vasculitis developed with bowel perforation and sepsis leading to death.
D001172:Arthritis, Rheumatoid / Q000000981:diagnostic imaging* / Q000188:drug therapy; D004334:Drug Administration Schedule; D005260:Female; D006801:Humans; D008875:Middle Aged; D010005:Osteoarthropathy, Secondary Hypertrophic / Q000000981:diagnostic imaging* / Q000188:drug therapy; D011241:Prednisone / Q000627:therapeutic use; D011658:Pulmonary Fibrosis / Q000150:complications* / Q000188:drug therapy; D011859:Radiography; D013582:Synovial Fluid / Q000032:analysis; D013585:Synovitis / Q000000981:diagnostic imaging
D011241:Prednisone