The adsorption of sympathomimetic agents by activated carbon hemoperfusion.
Sympathomimetic agents with mixed and pure alpha and beta adrenergic activity are adsorbed by coconut shell activated carbon from blood, sufficiently rapidly to markedly reduce the activity of these agents. The results of this study suggest that the site of injection of sympathomimetic agents being considered for correcting hypotension during activated carbon hemoperfusion be selected to permit systemic mixing before circulation into the adsorption device.
D000327:Adsorption; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D002244:Carbon; D003059:Cocos; D004285:Dogs; D004298:Dopamine / Q000378:metabolism / Q000494:pharmacology; D004837:Epinephrine / Q000097:blood / Q000494:pharmacology; D005112:Extracorporeal Circulation; D005898:Glass; D006339:Heart Rate / Q000187:drug effects; D007545:Isoproterenol / Q000097:blood / Q000494:pharmacology; D007700:Kinetics; D008297:Male; D008729:Methoxamine / Q000097:blood / Q000494:pharmacology; D009638:Norepinephrine / Q000097:blood / Q000494:pharmacology; D013566:Sympathomimetics / Q000097:blood*
D013566:Sympathomimetics; D002244:Carbon; D008729:Methoxamine; D007545:Isoproterenol; D004298:Dopamine; D009638:Norepinephrine; D004837:Epinephrine