Effects of tham, isoprenaline and propranolol on blood flow and vascular resistances of the liver after in- and outflow occlusion. Relation with the splanchnic shock.
The responsibility of the portal and the hepatic artery circulations during shock states has been established by studying the effects of a 15-min occlusion of two of the following blood vessels on 23 dogs: inferior vena cava below the diaphragm, portal vein and hepatic artery. Intrahepatic vascular resistances were computed from blood pressure records in these vessels and transhepatic blood flow studies using the 133Xe clearance method. The animals were treated with THAM, plasmagel, isoprenaline, and propranolol. The tolerance of the occlusion is significantly improved when the animals are treated with the association of the four drugs. The portal and the systemic arterial blood pressures return to normal more promptly. Sinusoid and peribiliary resistances are remarkably stable if compared to the changes occurring in the control animals. The well-known benefit of THAM is improved by the apparently paradoxical association of isoprenaline and propranolol. In fact, at the doses which have been used, they counterbalance their mutual disadvantages. Finally, the analysis of the hepatic blood flow rates and vascular resistances suggests that the splanchnic shock has two components: hepatic and visceral.
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D004285:Dogs; D004347:Drug Interactions; D005260:Female; D005780:Gelatin / Q000494:pharmacology; D006400:Hematocrit; D006499:Hepatic Artery / Q000502:physiology; D007545:Isoproterenol / Q000494:pharmacology*; D008026:Ligation; D008102:Liver Circulation / Q000187:drug effects*; D008297:Male; D011169:Portal Vein / Q000502:physiology; D011433:Propranolol / Q000494:pharmacology*; D012769:Shock / Q000503:physiopathology; D014325:Tromethamine / Q000494:pharmacology*; D014655:Vascular Resistance / Q000187:drug effects*; D014682:Vena Cava, Inferior / Q000502:physiology
D014325:Tromethamine; D005780:Gelatin; D011433:Propranolol; D007545:Isoproterenol