Application of occupational exposure limits to unusual work schedules.
A one-compartment exponential models is described which predicts "equal protection", based on biological uptake rates, for unusual air contaminant exposure situations as compared to a "normal" exposure of five 8-hour days per week. This is done by equating peak body burdens resulting from a normal and an unusual exposure, in terms of an adjustment factor applied to the normal exposure limit for an air contaminant. This factor predicts the highest allowable concentration in an unusual exposure situation which will not result in a higher-than normal body accumulation of the inhaled substance. Graphs and formulae are provided for determining adjustment factors for anticipated unusual exposure schedules. The model's predictions and published data are compared.
D000393:Air Pollutants / Q000633:toxicity*; D000395:Air Pollutants, Occupational / Q000633:toxicity*; D001822:Body Burden; D006207:Half-Life; D006801:Humans; D008452:Maximum Allowable Concentration; D008954:Models, Biological; D009787:Occupational Medicine / Q000592:standards*; D013997:Time Factors
D000393:Air Pollutants; D000395:Air Pollutants, Occupational