[Striato-nigral degeneration. Clinical and anatomic study of a case which responded favorably to L-Dopa].
The authors have reported the case of a 65 year old woman followed for almost 4 years with an akineticrigid Parkinsonian syndrome which responded well to levodopa. Waning of response finally occurred and despite the addition of a peripheral dopa decarboxylase inhibitor the patient died suddenly. Autopsy examination revealed pure nigro-striatal degeneration without any additional pathology. The report deals primarily with purity of the Parkinsonian picture and especially with the conspicuous and prolonged effect of levodopa.
D000368:Aged; D001927:Brain Diseases / Q000188:drug therapy* / Q000473:pathology; D002540:Cerebral Cortex / Q000473:pathology; D003342:Corpus Striatum / Q000473:pathology; D005260:Female; D006801:Humans; D007980:Levodopa / Q000627:therapeutic use*; D010300:Parkinson Disease / Q000188:drug therapy; D013378:Substantia Nigra / Q000473:pathology
D007980:Levodopa
Dégénérescence striato-nigrique. Etude clinique et anatomique d'un cas ayant réagi très favorablement à la L-Dopa.