title: [Metabolism of methiothepin in the rat, dog and man].
abstract: Report is given on a metabolic investigation with non-radioactive and 14C-labelled methiothepin(1-[10',11'-dihydro-8'-(methylthio)-dibenzo mean value of b,f thiepin-10'yl]-4-methyl-piperazine) in rat, dog, and man. After i.p. and oral administration of the drug to the rat, the metabolites of methiothepin were excreted fecally. In the same species, a considerable biliary secretion of the compounds has been demonstrated. In dog and in man, excreted metabolites have been found both in urine and feces after oral application of the drug. The biotransformation of methiothepin within the species investigated proceeds via hydroxylation, sulfoxidation, O-methylation, N-demethylation, N-oxidation and formation of conjugates. The large number of metabolites is due to the various sites of action within the molecule, that are accessible to in vivo oxidation. Of a large number of isolated positionally isomeric compounds, merely the basal structures could be clarified. Possibly the mode of biotransformation to which methiothepin is subjected in the organism, proves determinant for the way of excretion. In the rat, all metabolites are hydroxylated and reach the intestinal tract as conjugates with the bile. In dog and man, however, non-hydroxylated, sulfoxidized metabolites were likewise found, which were excreted mainly renally in both species.
mesh_terms: D000284:Administration, Oral; D000818:Animals; D001646:Bile / Q000378:metabolism; D001711:Biotransformation; D002852:Chromatography, Ion Exchange; D002855:Chromatography, Thin Layer; D003988:Dibenzothiepins / Q000378:metabolism*; D004285:Dogs; D005243:Feces / Q000032:analysis; D005260:Female; D006801:Humans; D006900:Hydroxylation; D007274:Injections, Intraperitoneal; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D013058:Mass Spectrometry; D008719:Methiothepin / Q000008:administration & dosage / Q000378:metabolism*; D008745:Methylation; D008875:Middle Aged; D010084:Oxidation-Reduction; D051381:Rats; D013045:Species Specificity; D013997:Time Factors
chemical_list: D003988:Dibenzothiepins; D008719:Methiothepin
vernacular_title: Zum Metabolismus von Methiothepin bei Ratte, Hund und Mensch