Clearance rate, half-life, and secretory potency of human gastrin-17-I in different species.
The clearance rates of synthetic human gastrin-17-I were measured in man, dog, and cat. Half-life of disappearance and acid secretory potency (D50) were also measured in man and dog. The clearance rates in dog and cat were, respectively, 3 and 8 times more than in man. Accordingly, the half-life of gastrin-17 in the dog (3.5 min) was 3 times shorter than in man (9.5 to 10.5 min). The D50 for acid secretion was proportional to the clearance rate and yielded approximately similar increments of serum gastrin, indicating an equal sensitivty to gastrin-17 at cellular level in the three species. An inverse allometric relation between clearance rate and body weight was consistent with the known greater efficiency of metabolic and eliminatory processes in species of small size. Recent studies of the disposal of other gastrointestinal hormones indicate that the concepts developed theoretically for secretory stimulants and confirmed experimentally for gastrin-17 may have wider applicability.
D000818:Animals; D001835:Body Weight; D002415:Cats; D004285:Dogs; D004305:Dose-Response Relationship, Drug; D005750:Gastric Juice / Q000378:metabolism; D005753:Gastric Mucosa / Q000187:drug effects / Q000378:metabolism; D005755:Gastrins / Q000008:administration & dosage / Q000097:blood* / Q000494:pharmacology; D006207:Half-Life; D006801:Humans; D007263:Infusions, Parenteral; D008297:Male; D008657:Metabolic Clearance Rate; D012636:Secretory Rate / Q000187:drug effects*; D013045:Species Specificity
D005755:Gastrins