[The effect of taurine on the carbohydrate metabolism of diabetic animals].
A study was made of a new antidiabetic preparation--taurin in various methods of its administration to rats and rabbits with alloxan and ditisone model of diabetes. A short-term restoration of carbohydrate metabolism was seen after intraperitoneal and intravenous injection in a dose of 200 mg/kg. Oral use of aqueous taurin solution in the same dose failed to produce the desirable result. Microcapsulated taurin with acetylcellulose in the capacity of a filler given per os in a dose of 300 mg/kg restored to the normal glycogen content in the liver and leukocytes, blood and urine sugar level, and the insulin-like activity of blood plasma. Taurin (in a concentration of 3 mg/ml) possessed an insulinogenic action in experiments on fragments of the pancreas isolated from diabetia animals.
D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D002214:Capsules; D003920:Diabetes Mellitus / Q000139:chemically induced / Q000188:drug therapy*; D003921:Diabetes Mellitus, Experimental / Q000188:drug therapy; D004230:Dithizone; D006003:Glycogen / Q000378:metabolism; D007962:Leukocytes / Q000378:metabolism; D008112:Liver Glycogen / Q000378:metabolism; D011817:Rabbits; D051381:Rats; D013654:Taurine / Q000008:administration & dosage / Q000627:therapeutic use*
D001786:Blood Glucose; D002214:Capsules; D008112:Liver Glycogen; D013654:Taurine; D004230:Dithizone; D006003:Glycogen
Vliianie taurina na uglevodnyĭ obmen diabeticheskikh zhivotnykh