title: Aldosterone secretion during high sodium cerebrospinal fluid perfusion of the brain ventricles.
abstract: Conscious sheep with permanent indwelling cannulae in the lateral ventricles and the cisterna magna were Na depleted and then perfused for 9 h with an artificial CSF solution. There were 3 experimental groups: Group I (n=5) received perfusion with aritifical CSF containing NA 170 MEq./1, Group II (n=7) received perfusion with artificial CSF containing Na 145 mEq./1, Group III (n=7) received no perfusion. In Group I the blood aldosterone level fell from 26.4 +/- 7.4 to 8.6 +/- 2.3 ng/100 ml by 9 h after perfusion. There was no significant change in plasma [Na] or [K], blood angiotensin II or plasma renin concentration. Blood cortisol and corticosterone levels rose. There was also a fall in post-perfusion. Group III showed no significant change in blood aldosterone concentration. Multivariate statistical analysis showed that the fall in aldosterone levels during 170 mEq./l Na perfusion could not be accounted for by changes, either alone or together, of ACTH as evidenced by alteration in blood cortisol or corticosterone, or by change of plasma [Na], [K] or renin concentrations. This data supports the hypothesis of an additional factor which may be of CNS origin being involved in the control of aldosterone secretion.
mesh_terms: D000450:Aldosterone / Q000378:metabolism*; D000804:Angiotensin II / Q000097:blood; D000818:Animals; D002552:Cerebral Ventricles; D002555:Cerebrospinal Fluid; D003345:Corticosterone / Q000097:blood; D005260:Female; D006854:Hydrocortisone / Q000097:blood; D008297:Male; D010477:Perfusion; D011188:Potassium / Q000097:blood; D012083:Renin / Q000097:blood; D012756:Sheep; D012964:Sodium / Q000494:pharmacology*
chemical_list: D000804:Angiotensin II; D000450:Aldosterone; D012964:Sodium; D012083:Renin; D011188:Potassium; D003345:Corticosterone; D006854:Hydrocortisone