Measurement of closing volume in apneic subjects.
Closing volume measurement was adapted for application in apneic intubated, artifically ventilated subjects. A bolus of nitrogen was used as the marker gas. Inspiration and exhalation at a slow, uniform rate between residual volume and total lung capacity was provided by a 7000-ml syringe. Closing volumes in seven anesthetized subjects were similar to those reported for supine, conscious individuals by previous investigators. This adaptation of closing volume measurement should be useful in studying pulmonary dysfunction during anesthesia and during artificial ventilation of patients in respiratory failure.
D000328:Adult; D000768:Anesthesia, General; D001049:Apnea / Q000503:physiopathology*; D005260:Female; D006801:Humans; D008176:Lung Volume Measurements / Q000379:methods*; D008297:Male; D008875:Middle Aged; D012123:Pulmonary Ventilation / Q000379:methods; D012121:Respiration, Artificial