Rheological evaluation of hog gastric mucin as a model mucus system.
The rheological evaluation of preparations containing 10, 15, 20, and 25% powdered hog gastric mucin was carried out over the 13-48 degrees temperature range using rotational and creep viscometry. The preparations were almost viscous, and no elastic behavior was demonstrated. The addition of borate ions frequently produced a slight decrease in viscosity. Tetracycline hydrochloride decreased the viscosity of the 10 and 25% materials, although the addition of this compound to fresh gastric and bronchial mucous gels markedly increased viscosity. The model is, therefore, only suitable in limited circumstances as a basis for the evaluation of the effect of drugs on gastric mucus.
D000818:Animals; D001881:Borates; D005752:Gastric Mucins; D066298:In Vitro Techniques; D008954:Models, Biological; D009093:Mucus; D012212:Rheology; D013552:Swine; D013696:Temperature; D013752:Tetracycline; D013997:Time Factors; D014783:Viscosity
D001881:Borates; D005752:Gastric Mucins; D013752:Tetracycline