title: [Effect of obsidan on the systemic hemodynamics of dogs in ontogeny].
abstract: Investigations on dogs of different age have brought evidence that intravenous administration of 2 mg/kg of obsidan (propranolol hydrochloride) causes in 18-22-day old puppies a fall of arterial pressure due to a reduced cardiac ejection with little changing total vascular peripheral resistance. The frequency of the rhythm and conduction in the heart are slowed down. In dogs aged 3-5 years the arterial pressure remains unchanged, since the diminution of the cardiac output is attended by a greater vascular resistance.
mesh_terms: D000367:Age Factors; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D002306:Cardiac Volume / Q000187:drug effects; D004285:Dogs; D006339:Heart Rate / Q000187:drug effects; D006439:Hemodynamics / Q000187:drug effects*; D011433:Propranolol / Q000494:pharmacology*; D014655:Vascular Resistance / Q000187:drug effects
chemical_list: D011433:Propranolol
vernacular_title: Vliianie obzidana na sistemnuiu gemodinamiku u sobak v ontogeneze.