Screening large numbers of compounds in a model based on mortality of Trypanosoma rhodesiense infected mice.
A test system has been developed to evaluate the trypanosomicidal activity of large numbers of candidate drugs. Based on mortality of mice with blood induced Trypanosoma rhodesiense infections, it serves as a primary screen or as a secondary and confirmatory test for active compounds. Over 5,500 selected compounds have been tested; more than 6% were active.
D000818:Animals; D004195:Disease Models, Animal; D004353:Drug Evaluation, Preclinical; D051379:Mice; D012556:Schistosomicides / Q000627:therapeutic use; D013266:Stilbamidines / Q000627:therapeutic use; D014344:Trypanocidal Agents / Q000627:therapeutic use*; D014345:Trypanosoma / Q000187:drug effects*; D014352:Trypanosomiasis / Q000188:drug therapy* / Q000401:mortality
D012556:Schistosomicides; D013266:Stilbamidines; D014344:Trypanocidal Agents