Pityriasis rubra pilaris. A clinico-pathological study with a special reference to autoradiography and histocompatibility antigens.
In a clinical study, 27 of 31 cases of pityriasis rubra pilaris (PRP) had two or more of the following clinical features: erythroderma, well-confined healthy islands inside the inflammatory areas, keratoderma of the palms and soles, or visible follicular hyperkeratosis. Histological features were: perifollicular parakeratosis in 26 cases, hyperkeratosis in 27 cases; the number of granular layers varied greatly from case to case and within one specimen; acanthosis was eczematous in 20 cases and psoriasiform in 8 cases. Erythroderma in PRP  in this study was self-healing, lasting 2-6 months with one exception, but PRP must as a whole be considered a mild, chronic disease lasting on average 5.7 years. Complete recovery occurred in only 8 patients and 5 of these had had an erythrodermic onset. Serum vitamin A level and tolerance test were normal. No immunological aberrations could be found. The HLA phenotype frequencies in PRP patients did not differ significantly from those in a Finnish control population. The autoradiographic study of the epidermal cells showed an increase in the cell production in the epidermis.
D000293:Adolescent; D000328:Adult; D000368:Aged; D000906:Antibodies; D001345:Autoradiography; D002648:Child; D002675:Child, Preschool; D005260:Female; D005787:Gene Frequency; D006649:Histocompatibility Antigens; D006801:Humans; D008297:Male; D008875:Middle Aged; D010641:Phenotype; D010916:Pityriasis Rubra Pilaris / Q000175:diagnosis* / Q000235:genetics / Q000276:immunology / Q000473:pathology; D011379:Prognosis; D012867:Skin / Q000473:pathology; D014801:Vitamin A / Q000097:blood
D000906:Antibodies; D006649:Histocompatibility Antigens; D014801:Vitamin A