title: Mesangiocapillary glomerulonephritis in lambs. III. Quantitative and qualitative aspects of immunopathology.
abstract: Newborn Finnish Landrace lambs subsequently affected with mesangiocapillary glomerulonephritis (MCGN) were deficient in the third component of complement (C'3), serum levels being approximately 5 per cent. of those in unaffected lambs. Hypocomplementaemia persisted until symptoms of renal failure occurred at around 6-8 wk of age. Immunofluorescence examinations of renal cortex with antisera specific for IgG, IgM, IgA, C'3 and fibrin supported previous morphological evidence of a strong similarity between this disease and MCGN in man. Similar examinations of choroid plexus suggested that immune complexes containing IgG, IgM and C'3 were present in the interstitium.
mesh_terms: D000818:Animals; D002831:Choroid Plexus / Q000032:analysis / Q000276:immunology / Q000473:pathology; D003126:Colostrum / Q000276:immunology; D003176:Complement C3 / Q000032:analysis; D003165:Complement System Proteins / Q000032:analysis; D005337:Fibrin / Q000032:analysis; D005921:Glomerulonephritis / Q000276:immunology / Q000473:pathology / Q000662:veterinary*; D007070:Immunoglobulin A / Q000032:analysis; D007074:Immunoglobulin G / Q000032:analysis; D007075:Immunoglobulin M / Q000032:analysis; D007136:Immunoglobulins / Q000032:analysis; D007672:Kidney Cortex / Q000032:analysis / Q000276:immunology / Q000473:pathology; D012756:Sheep; D012757:Sheep Diseases / Q000473:pathology
chemical_list: D003176:Complement C3; D007070:Immunoglobulin A; D007074:Immunoglobulin G; D007075:Immunoglobulin M; D007136:Immunoglobulins; D005337:Fibrin; D003165:Complement System Proteins