Effect of 2-chloroethanol on hepatic microsomal enzymes in the rat.
The effect of 2-chloroethanol on the activities of hepatic microsomal enzymes in the rat has been studied. A significant reduction in activities of drug-metabolizing enzymes (aminopyrine N-demethylase, coumarin 3-hydroxylase) and a marked decrease of glucose 6-phosphatase were seen in both sexes given dose levels of 20 mg/kg sc daily for 7 days. Inosine diphosphatase activity remained unaltered. In male rats given 3 or 10 mg/kg, a trend in the inhibition of drug metabolism was found. A single dose of 50 mg/kg caused no apparent change in the activities of the enzymes measured.
D000818:Animals; D002728:Chlorohydrins / Q000494:pharmacology*; D005023:Ethylene Chlorohydrin / Q000494:pharmacology*; D005260:Female; D008297:Male; D008862:Microsomes, Liver / Q000187:drug effects / Q000201:enzymology*; D051381:Rats; D012737:Sex Factors
D002728:Chlorohydrins; D005023:Ethylene Chlorohydrin