Use of tissue culture to examine neurotoxicity of contrast media.
The effect of small concentrations of diatrizoate, ioglycamate, and iopanoate salts on cultured sympathetic ganglia was studied. Biliary contrast media in clinical blood concentrations caused severe degeneration of cultured neurons, but similar concentrations of diatrizoate caused no effect. This technique may be used to measure the direct neurotoxicity or general cytotoxicity of contrast media.
D000818:Animals; D002642:Chick Embryo; D003287:Contrast Media / Q000633:toxicity*; D046508:Culture Techniques; D003973:Diatrizoate / Q000633:toxicity; D005725:Ganglia, Autonomic / Q000187:drug effects*; D007471:Ioglycamic Acid / Q000633:toxicity; D007480:Iopanoic Acid / Q000633:toxicity; D009416:Nerve Regeneration / Q000187:drug effects; D009474:Neurons / Q000187:drug effects
D003287:Contrast Media; D003973:Diatrizoate; D007471:Ioglycamic Acid; D007480:Iopanoic Acid