Myodystrophy, a new myopathy on chromosome 8 of the mouse.
A new recessive mutation, myd, causing a diffuse and progressive myopathy in the mouse is described. Histopathological comparisons with normal littermates showed widely distributed focal lesions in all skeletal muscles of myd/myd. Body and organ weights of affected mice were considerably less than those of normal littermates and the mean lifespan of myodystrophic mice that survived weaning was 17 weeks with a range of 5 to 39 weeks. Myodystrophy is located on chromosome 8; it is linked to Os with about 6 percent and to Eso with about 37 percent recombination.
D000818:Animals; D002874:Chromosome Mapping; D003433:Crosses, Genetic; D005260:Female; D005796:Genes; D005808:Genes, Recessive; D008040:Genetic Linkage; D008297:Male; D051379:Mice; D009135:Muscular Diseases / Q000235:genetics / Q000662:veterinary*; D009154:Mutation; D010641:Phenotype; D010858:Pigmentation; D012376:Rodent Diseases / Q000235:genetics*