Morphine suppression of ethanol withdrawal in mice.
The acute administration of morphine, alcohol or dopamine results in a pronounced suppression of the convulsions produced by alcohol in mice. The suppressive action of morphine on alcohol withdrawal in the mouse apparently is not a product of morphine intoxication, but rather to some other specific interaction between alcohol and morphine in the central nervous system. The conclusion suggest that dopamine may play a significant role as a modulator in convulsions produced during alcohol withdrawal.
D000437:Alcoholism; D000818:Animals; D001921:Brain; D002555:Cerebrospinal Fluid / Q000502:physiology; D004298:Dopamine / Q000008:administration & dosage / Q000627:therapeutic use; D000431:Ethanol / Q000008:administration & dosage; D006801:Humans; D007267:Injections; D051379:Mice; D009020:Morphine / Q000008:administration & dosage / Q000627:therapeutic use*; D012640:Seizures / Q000188:drug therapy; D013375:Substance Withdrawal Syndrome / Q000188:drug therapy*
D000431:Ethanol; D009020:Morphine; D004298:Dopamine