The effect of alpha-1-acetylmethadol hydrochloride on rat hepatic aryl hydrocarbon hydroxylase and epoxide hydrase.
Male and female Wistar rats were administered alpha-1-acetylmethadol via their drinking water for one to two weeks. Hepatic aryl hydrocarbon hydroxylase, cytochrome P-450 and epoxide hydrase activities were measured after various doses of this drug. In female rats, a significant increase in aryl hydrocarbon hydroxylase and cytochrome P-450 occurred at doses as low as 4.7 mg/Kg/day. However, no change in epoxide hydrase activity occurred. In male rats, a significant increase in epoxide hydrase activity occurred at all doses tested. From these results, it is concluded that alpha-1-acetylmethadol induces a number of hepatic drug metabolizing enzyme systems.
D000818:Animals; D001189:Aryl Hydrocarbon Hydroxylases / Q000378:metabolism*; D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism; D004851:Epoxide Hydrolases / Q000378:metabolism*; D005260:Female; D066298:In Vitro Techniques; D008297:Male; D008691:Methadone / Q000031:analogs & derivatives*; D008692:Methadyl Acetate / Q000494:pharmacology*; D008862:Microsomes, Liver / Q000187:drug effects / Q000201:enzymology*; D009043:Motor Activity / Q000187:drug effects; D051381:Rats; D013268:Stimulation, Chemical
D003577:Cytochrome P-450 Enzyme System; D001189:Aryl Hydrocarbon Hydroxylases; D004851:Epoxide Hydrolases; D008692:Methadyl Acetate; D008691:Methadone