Studies of the herbicide paraquat. I. Effects on the cell cycle and DNA synthesis in Vicia faba.
Vicia faba root tips were exposed to concentrations of paraquat ranging from 10-3M to 10-6M. There was a statistically significant inhibition in 3H-thymidine incorporation, and, therefore, presumably of DNA synthesis by all concentrations of paraquat studied. All concentrations of paraquat also had a statistically significant effect on the percentage of cells in division at various hours following paraquat treatment. At 10-3M and 10-4M paraquat there was an almost total inhibition in the number of cells moving from the S period and through the G2 period and into division. Cells treated with 10-6M paraquat, however, did move through the G2 period and into division. A concentration of 10-4M paraquat did not result in an increase in chromosome aberrations.
D002455:Cell Division / Q000187:drug effects; D002875:Chromosomes / Q000187:drug effects; D004247:DNA / Q000096:biosynthesis*; D010269:Paraquat / Q000494:pharmacology*; D059828:Plant Cells; D010944:Plants / Q000187:drug effects* / Q000378:metabolism; D013936:Thymidine / Q000378:metabolism
D004247:DNA; D010269:Paraquat; D013936:Thymidine