Cardiovascular toxicity of dihydroxytryptamines.
A comparison of the acute toxicity and a histological examination of the toxic effects in mouse of 4,7-; 5,6-; 5,7- and 6,7-dihydroxytryptamines and related compounds are present. A time and dose dependent induction of subepicardial lesions by 5,6-dihydroxytryptamine is demonstrated. The development of ischemic necrosis of the vaculature of the tail following 6,7-dihydroxytryptamine is described. The toxic effects of these tryptamines are discussed with regard to the phenomena of specific neurodegeneration induced by 5,6- and 5,7-dihydroxytryptamines.
D015115:5,6-Dihydroxytryptamine / Q000633:toxicity; D000818:Animals; D006321:Heart / Q000187:drug effects*; D006331:Heart Diseases / Q000139:chemically induced; D008099:Liver / Q000187:drug effects; D008297:Male; D051379:Mice; D009206:Myocardium / Q000473:pathology; D009336:Necrosis / Q000139:chemically induced / Q000473:pathology; D012701:Serotonin / Q000031:analogs & derivatives* / Q000633:toxicity; D013997:Time Factors
D012701:Serotonin; D015115:5,6-Dihydroxytryptamine