Polymorphonuclear leukocytes: possible mechanism of accumulation in psoriasis.
Extracts of involved and uninvolved skin from nine patients with untreated psoriasis were studied for chemotactic activity. Psoriatic plaque contains increased amounts of a complement-dependent chemotactic factor that is inhibited by diisopropyl fluorophosphate. This factor may be human skin serine proteinase.
D000818:Animals; D001681:Biological Assay; D002634:Chemotaxis, Leukocyte / Q000187:drug effects; D003165:Complement System Proteins / Q000378:metabolism*; D006801:Humans; D007531:Isoflurophate / Q000494:pharmacology; D051379:Mice; D009504:Neutrophils / Q000276:immunology*; D010447:Peptide Hydrolases / Q000378:metabolism; D011480:Protease Inhibitors; D011565:Psoriasis / Q000201:enzymology / Q000276:immunology*
D011480:Protease Inhibitors; D007531:Isoflurophate; D003165:Complement System Proteins; D010447:Peptide Hydrolases