Synthesis of 1- and 2-substituted indazoles as anthelmintic agents.
Selective synthesis of 1- and 2-acyl-, alkoxycarbonyl-, and carbamoylindazoles are described. Spectroscopic data which were the basis for structural assignments are presented. These compounds, particularly methyl 2H-indazole-2-carboxylate and N-heptyl-N-methyl-2H-indazole-2-carboxamide, lack the spectrum of anthelmintic activity of the benzimidazole and benzotriazole anthelmintics to which they are structurally related.
D000818:Animals; D000871:Anthelmintics / Q000138:chemical synthesis* / Q000627:therapeutic use; D007191:Indazoles / Q000138:chemical synthesis* / Q000627:therapeutic use; D007536:Isomerism; D009682:Magnetic Resonance Spectroscopy; D051379:Mice; D009349:Nematode Infections / Q000188:drug therapy / Q000662:veterinary; D011720:Pyrazoles / Q000138:chemical synthesis*; D012756:Sheep; D012757:Sheep Diseases / Q000188:drug therapy; D013056:Spectrophotometry, Ultraviolet; D014235:Trichinellosis / Q000188:drug therapy
D000871:Anthelmintics; D007191:Indazoles; D011720:Pyrazoles