Inhibitory effect of furosemide on glucose transport.
The carrier-mediated glucose transport function in the intact human erythrocytes and also that of their isolated membranes is markedly inhibited in the presence of furosemide in vitro. A noncompetitive process is believed to be involved since the transport inhibition was not affected by the presence of high concentrations of glucose in the medium. The inhibition developed slowly over 2 hours. Most of the inhibition was slowly reversed during a 3-hour incubation in medium free of the drug. It is concluded that furosemide inhibits the glucose transport function directly in absence of insulin-mediated transduction mechanism and independently of any interference with intracellular glycolysis.
D001693:Biological Transport, Active / Q000187:drug effects; D002462:Cell Membrane / Q000378:metabolism; D002463:Cell Membrane Permeability / Q000187:drug effects; D002740:Chlorothiazide / Q000494:pharmacology; D003981:Diazoxide / Q000494:pharmacology; D004912:Erythrocytes / Q000378:metabolism; D005665:Furosemide / Q000494:pharmacology*; D005947:Glucose / Q000378:metabolism*; D006801:Humans; D011485:Protein Binding / Q000187:drug effects; D014882:Water-Electrolyte Balance
D002740:Chlorothiazide; D005665:Furosemide; D005947:Glucose; D003981:Diazoxide