Gonadotropin-inhibitory contaminants in partially purified pharmaceutical preparations of human chorionic gonadotropin.
Various commercial preparations of partially purified human chorionic gonadotropin, inactivated by heating, inhibited the uterine growth induced in immature mice with the same active gonadotropins as well as spontaneous uterine growth. The more purified preparations of chorionic gonadotropin failed to produce these effects after inactivation by boiling, suggesting that the inhibitory activity is not generated from gonadotropin by the procedure but may be related to some contaminant similar to the gonadotropin-inhibitory substance previously found in human urine.
D000818:Animals; D001681:Biological Assay; D006063:Chorionic Gonadotropin / Q000032:analysis* / Q000037:antagonists & inhibitors / Q000494:pharmacology; D004340:Drug Contamination; D005260:Female; D051379:Mice; D008807:Mice, Inbred BALB C; D014599:Uterus / Q000187:drug effects / Q000254:growth & development; D014621:Vagina / Q000187:drug effects
D006063:Chorionic Gonadotropin