Suppression of the progress of necrosis after coronary artery ligation in the dog by pharmacologic interventions.
A study was carried out of a therapy supporting the anaerobic glycolysis and coronary perfusion of ischemic myocardium and preserving its potassium and magnesium contents, which consisted in combined administration of hyaluronidase, glucose, insulin, Tris, methoxamine, and potassium and magnesium aspartate. The drugs were administered to Beagle dogs between 30 minutes and 20 hours after the ligation of the left anterior descending coronary artery. The size of infarction was determined by the Nachlas method, which is based on the detection of activities of dehydrogenases in heart slices. Treated animals showed a reduced infarction size (p less than 0.001). The evidence of the favourable effect of the therapy used was brought also by hemodynamic measurements. The heart rate was slower (p less than 0.02) and the mean arterial blood pressure was higher (p less than 0.001) in treated animals than in control ones (as evaluated at the end of the experimental period). Significant correlation between the infarction size and the heart rate on the one hand and the mean arterial pressure on the other hand was found (r = 0.59, p less than 0.01; r=--0.47, p less than 0.05, respectively).
D000818:Animals; D004195:Disease Models, Animal; D004285:Dogs; D004359:Drug Therapy, Combination; D005947:Glucose / Q000627:therapeutic use*; D006821:Hyaluronoglucosaminidase / Q000627:therapeutic use*; D007328:Insulin / Q000627:therapeutic use*; D008274:Magnesium / Q000008:administration & dosage; D008729:Methoxamine / Q000627:therapeutic use*; D009203:Myocardial Infarction / Q000517:prevention & control*; D009336:Necrosis / Q000517:prevention & control; D011188:Potassium / Q000008:administration & dosage; D014325:Tromethamine / Q000627:therapeutic use*
D007328:Insulin; D014325:Tromethamine; D006821:Hyaluronoglucosaminidase; D008729:Methoxamine; D008274:Magnesium; D005947:Glucose; D011188:Potassium