Juvenile glaucoma associated with goniodysgenesis.
Clinicopathologic studies, including electron microscopy, of trabeculectomy and peripheral iridectomy specimens from three patients with "juvenile" glaucoma revealed varying forms of maldevlopment of the chamber angle in all cases. A 20-year-old white woman (Case 1) had associated iridogoniodysgenesis with a pseudopolycoria-like iris pattern. In a 39-year-old white woman (Case 2), goniodysgenesis was associated with degenerated cell remnants in the angle "cleavage" area. A 15-year-old mentally retarded white boy (Case 3) displayed features of juvenile pigmentary glaucoma with associated goniodysgenesis and megalocornea.
D000293:Adolescent; D000328:Adult; D000867:Anterior Chamber / Q000002:abnormalities*; D002648:Child; D002675:Child, Preschool; D003315:Cornea / Q000473:pathology; D003316:Corneal Diseases / Q000150:complications; D003886:Descemet Membrane / Q000473:pathology / Q000648:ultrastructure; D005260:Female; D005901:Glaucoma / Q000150:complications / Q000473:pathology*; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007498:Iris / Q000473:pathology / Q000648:ultrastructure; D008297:Male; D014602:Uvea / Q000473:pathology / Q000648:ultrastructure