title: Preferential inhibition by poly(adenylic acid) of minus-strand synthesis by bacteriophage Qbeta ribonucleic acid replicase.
abstract: Among the homopolymers examined, poly(A) was found to inhibit preferentially the synthesis of the minus strand by bacteriophage Qbeta RNA replicase in the presence of host factor. A specific interaction of poly(A) with the host factor is suggested to be a principal cause for the observed preferential inhibition by poly(A) of the host-factor-requiring Qbeta RNA replicase reaction.
mesh_terms: D000249:Adenosine Monophosphate / Q000494:pharmacology; D003090:Coliphages / Q000201:enzymology; D007700:Kinetics; D011061:Poly A / Q000494:pharmacology*; D011066:Poly C / Q000494:pharmacology; D011072:Poly U / Q000494:pharmacology; D012316:RNA Nucleotidyltransferases / Q000037:antagonists & inhibitors*; D012367:RNA, Viral / Q000096:biosynthesis*; D012324:RNA-Dependent RNA Polymerase / Q000037:antagonists & inhibitors*; D014764:Viral Proteins / Q000037:antagonists & inhibitors
chemical_list: D012367:RNA, Viral; D014764:Viral Proteins; D011061:Poly A; D011072:Poly U; D011066:Poly C; D000249:Adenosine Monophosphate; D012316:RNA Nucleotidyltransferases; D012324:RNA-Dependent RNA Polymerase