Morphine metabolism in opiate dependent and normal men by double isotope techniques.
A mixture of morphine-63H and morphine-N-14CH3 was administered to an opiate dependent and to a normal male subject. In both subjects the urinary excretion of radioactivity was rapid and exceeded 85% of the dose over 72 hours. The extent and time pattern of N-demethylation differed in the two subjects with N-demethylation of morphine being slower and less in the opiate addict. The use of the double isotope technique in detecting small changes in morphine metabolism is discussed.
D000328:Adult; D002250:Carbon Radioisotopes; D004361:Drug Tolerance; D006801:Humans; D006868:Hydrolysis; D008297:Male; D009020:Morphine / Q000378:metabolism* / Q000652:urine; D019966:Substance-Related Disorders / Q000378:metabolism*; D013997:Time Factors; D014316:Tritium
D002250:Carbon Radioisotopes; D014316:Tritium; D009020:Morphine