title: Tumoral calcinosis: a manifestation of extreme metastatic calcification occurring with 1, alpha-hydroxycholecalciferol therapy.
abstract: Two cases are reviewed, both of which developed tumoral calcinosis whilst receiving 1, alpha-hydroxy-cholecalciferol therapy. Tumoral calcinosis is an extreme form of peri-articular calcification, and its occurrence in patients with chronic renal failure is unusual. These peri-articular masses developed around the shoulders in both patients, and the action of 1, alpha-hydroxycholecalciferol as a possible factor promoting this form of metastatic calcification is discussed.
mesh_terms: D000328:Adult; D002114:Calcinosis / Q000209:etiology*; D005260:Female; D005921:Glomerulonephritis / Q000188:drug therapy; D006801:Humans; D006887:Hydroxycholecalciferols / Q000009:adverse effects* / Q000627:therapeutic use; D007676:Kidney Failure, Chronic / Q000150:complications*; D008297:Male; D008875:Middle Aged; D011859:Radiography; D012782:Shoulder / Q000000981:diagnostic imaging
chemical_list: D006887:Hydroxycholecalciferols