Actions of growth hormone-release inhibiting hormone (somatostatin) on the renin aldosterone system.
Administration of growth hormone-release inhibiting hormone (GH-RIH, somatostatin), as a 90 minute infusion (10 mug/min), to 3 healthy young men under conditons of active renin secretion acheived by pretreatment with furosemide (80 mg daily for 5 days), caused a mean 30% fall in plasma renin activity, which returned to basal levels immediately after stopping the GH-RIH infusion. Plasma aldosterone levels were not affected during the course of this experiment.
D000328:Adult; D000450:Aldosterone / Q000097:blood*; D000804:Angiotensin II / Q000097:blood; D003864:Depression, Chemical; D005665:Furosemide / Q000494:pharmacology; D006801:Humans; D007263:Infusions, Parenteral; D008297:Male; D012083:Renin / Q000097:blood*; D012964:Sodium / Q000378:metabolism; D013004:Somatostatin / Q000008:administration & dosage / Q000494:pharmacology*; D013997:Time Factors
D000804:Angiotensin II; D000450:Aldosterone; D013004:Somatostatin; D005665:Furosemide; D012964:Sodium; D012083:Renin