title: Free cortisol in obesity; effect of fasting.
abstract: Plasma and urinary corticosteroids were measured in 13 obese subjects before and after high and low protein diets, and after fasting. During isocaloric high and low protein diets, urinary 17-oxogenic steroids and to a lesser extent urinary free cortisol excretion rose and fell in parallel with protein intake. Plasma unbound cortisol levels were not much changed by high or low protein intake. However, during 7 to 11 days total fasting, there was a highly significant rise in plasma unbound cortisol at 24.00. A smaller rise occurred at 09.00. The overall effect was a considerable diminution of the day-night variation of plasma unbound coritsol levels during fasting, and a rise in prevailing unbound cortisol levels and urinary free cortisol excretion. In 3 subjects tested these changes were reversed immediately by glucose re-feeding.
mesh_terms: D015068:17-Ketosteroids / Q000652:urine; D002940:Circadian Rhythm; D004044:Dietary Proteins; D005215:Fasting; D006801:Humans; D006854:Hydrocortisone / Q000097:blood / Q000378:metabolism* / Q000652:urine; D009765:Obesity / Q000097:blood* / Q000178:diet therapy
chemical_list: D015068:17-Ketosteroids; D004044:Dietary Proteins; D006854:Hydrocortisone