title: Effects of prednisolone metasulfabenzoate on the induction of DNase II in comparison to alkaline phosphatase and acid phosphatase activities in cultures of HeLa S3 cells.
abstract: Cultures of HeLa S3 cells were treated with prednisolone metasulfobenzoate (Na), a derivative of prednisolone which is readily soluble in water. The steroid induced an increase in DNase II, a lysosomal enzyme which was not used previously in enzyme induction by steroids. Alkaline phosphatase, a known inducible enzyme by other steroids and acid phosphatase, a known uninducible enzyme by other steroids, were included for comparative reasons.
mesh_terms: D000135:Acid Phosphatase / Q000096:biosynthesis*; D000469:Alkaline Phosphatase / Q000096:biosynthesis*; D003851:Deoxyribonucleases / Q000096:biosynthesis*; D004305:Dose-Response Relationship, Drug; D004790:Enzyme Induction; D006367:HeLa Cells / Q000201:enzymology; D011239:Prednisolone / Q000031:analogs & derivatives* / Q000494:pharmacology; D012995:Solubility; D013997:Time Factors
chemical_list: C013218:prednisolone 21-3-sulfobenzoate; D011239:Prednisolone; D003851:Deoxyribonucleases; D000469:Alkaline Phosphatase; D000135:Acid Phosphatase