title: Therapeutic activity of sulphadimethoxine and bifuran against E. tenella and effect of medication on the development of immunity.
abstract: Therapeutic activity of sulphadimethoxine and Bifuran in drinking water against different levels of infection (5,000 10,000, 25,000 and 50,000 oocysts per chick) with Eimeria tenella and effect of medication on development of immunity was assessed. Medication was started after 96 hours of the infection. Sulphadimethoxine gave better control (performance indices: 234, 193, 155 and 112, respectively) than Bifuran (performance indices: 194, 129, 74 and 40, respectively) against all levels of the infection tested. Effectiveness of both the drugs decreased with increasing levels of the infection. Both the drugs interfered in the development of immunity which was inversely proportionate to the level of infection. Interference in development of immunity was more with sulphadimethoxine but these chicks were still solidly immune to the challenge infection.
mesh_terms: D000818:Animals; D002645:Chickens; D003048:Coccidiosis / Q000188:drug therapy* / Q000276:immunology; D004195:Disease Models, Animal; D004338:Drug Combinations; D004353:Drug Evaluation, Preclinical; D004539:Eimeria / Q000187:drug effects / Q000302:isolation & purification; D005243:Feces / Q000382:microbiology; D005664:Furazolidone / Q000627:therapeutic use*; D009583:Nitrofurazone / Q000627:therapeutic use*; D013412:Sulfadimethoxine / Q000627:therapeutic use*; D013607:Tablets; D014881:Water Supply
chemical_list: D004338:Drug Combinations; D013607:Tablets; D013412:Sulfadimethoxine; D005664:Furazolidone; D009583:Nitrofurazone