Adenine metabolism during and after exchange transfusions in newborn infants with CPD-adenine blood.
CPD-adenine blood (adenine in a final concentration of 0.25 mmol/1) was used in exchange transfusions in four newborn infants. The amount of adenine in one exchange transfusion ranged from 27 to 29 mumol per kg bodyweight. The maximum P-adenine concentration during the exchange transfusions ranged from 4 to 8 mumol/1 but decreased to pretransfusion levels 20 minutes after the exchange transfusions. During a 24-hour period following the exchange transfusions, the total urine excretion of adenine and 2,8-dihydroxyadenine corresponded to 0.5 to 1.3 per cent of the given adenine dose calculated on a molar basis. Accumulated data indicate that CPD-adenine blood can be used even in repeated exchange transfusions in newborn infants.
D000225:Adenine / Q000031:analogs & derivatives / Q000378:metabolism* / Q000652:urine; D001793:Blood Preservation; D002951:Citrates; D004899:Erythroblastosis, Fetal / Q000628:therapy*; D005078:Exchange Transfusion, Whole Blood; D005260:Female; D005947:Glucose; D006801:Humans; D007231:Infant, Newborn; D010710:Phosphates; D011247:Pregnancy; D013997:Time Factors
D002951:Citrates; D010710:Phosphates; D005947:Glucose; D000225:Adenine