Early radiographic manifestations of secondary hyperparathyroidism associated with chronic renal disease.
The hands of 29 chronic dialysis patients were evaluated every 3 months for subperiosteal, intracortical, and endosteal bone resorption using fine-detail radiography and optical magnification. All patients with significant endosteal resorption also had progressive subperiosteal resorption and substantial or progressive intracortical resorption. All patients with a significantly elevated parathyroid hormone or alkaline phosphatase level had radiographic evidence of progressive bone loss. Fourteen (61%) of the 23 patients with well-controlled serum phosphate levels (mean 4.7 +/- 0.2 mg/dl) treated with supplemental calcium and dihydrotachysterol nevertheless had increased subperiosteal or endosteal resorption. Serial radiography proved to be a valuable method of evaluating progressive bone resorption.
D000293:Adolescent; D000328:Adult; D000368:Aged; D001862:Bone Resorption; D005260:Female; D006801:Humans; D006962:Hyperparathyroidism, Secondary / Q000097:blood / Q000000981:diagnostic imaging* / Q000209:etiology; D007676:Kidney Failure, Chronic / Q000097:blood / Q000150:complications*; D008297:Male; D008663:Metacarpus / Q000000981:diagnostic imaging*; D008875:Middle Aged; D010281:Parathyroid Hormone / Q000097:blood; D011859:Radiography
D010281:Parathyroid Hormone