[Influence of acute alcohol intoxication on the synthesis of RNA and proteins in the liver of rats at various times of the day].
An acute alcoholic poisoning occurring 12 hours after intragastric administration of a 40 degrees ethanol (1.5 ml/kg) produced at 9 and 21 hours an inhibitory action on the incorporation of H3-uridine in the nuclei and cytoplasm, as well as of S35-methionine in the cytoplasm of the hepatic cells in rats. An alcohol inhibition of the RNA and protein synthesis at different time of the day proved dissimilar. Intact animals demonstrated significant diurnal variations in the intensity of the isotopes incorporation in the nuclei and cytoplasm of hepatocytes which continued after the action of alcohol, with the incorporation maximum at 21 and minimum at 9 hours.
D000208:Acute Disease; D000435:Alcoholic Intoxication / Q000378:metabolism*; D000818:Animals; D002467:Cell Nucleus / Q000187:drug effects; D056486:Chemical and Drug Induced Liver Injury / Q000378:metabolism*; D002940:Circadian Rhythm / Q000187:drug effects*; D003593:Cytoplasm / Q000187:drug effects; D006801:Humans; D008099:Liver / Q000378:metabolism*; D008715:Methionine / Q000378:metabolism; D014176:Protein Biosynthesis; D012313:RNA / Q000096:biosynthesis*; D051381:Rats; D014529:Uridine / Q000378:metabolism
D012313:RNA; D008715:Methionine; D014529:Uridine
Vliianie ostroĭ alkogol'noĭ intoksikatsii na sintez RNK i belkov v pecheni krys v raznoe vremia sutok