Collagen diseases and the biosynthesis of collagen.
Increasing knowledge concerning the molecular structure of collagen and the steps involved in its biosynthesis provides the basis for a new look at the collagen diseases. Some, like the Ehlers-Danlos syndrome, are now known to be the expression of primary molecular defects; others, such as scurvy and scleroderma, appear to be secondary to some process that disrupts normal controls over collagen synthesis or deposition.
D000595:Amino Acid Sequence; D003094:Collagen / Q000096:biosynthesis*; D003095:Collagen Diseases / Q000378:metabolism*; D004535:Ehlers-Danlos Syndrome / Q000378:metabolism; D004721:Endoplasmic Reticulum / Q000378:metabolism; D005110:Extracellular Space / Q000378:metabolism; D006801:Humans; D006900:Hydroxylation; D008968:Molecular Conformation; D011347:Procollagen / Q000378:metabolism; D014176:Protein Biosynthesis; D012333:RNA, Messenger / Q000502:physiology; D012595:Scleroderma, Systemic / Q000378:metabolism; D013329:Structure-Activity Relationship
D011347:Procollagen; D012333:RNA, Messenger; D003094:Collagen