Kinetic evaluation of thiopentone sodium stability in aqueous and propylene glycol medium.
Stability of thiopentone sodium (TP) was investigated by means of accelerated testing at elevated temperature and pH ca. 10. The experiments carried out do not argue for propylene glycol as a good solvent for the preparations of an injectable TP solution because the shelf-life time predicted is more favourable for the aqueous solution.
D004355:Drug Stability; D007700:Kinetics; D011409:Propylene Glycols; D013056:Spectrophotometry, Ultraviolet; D013696:Temperature; D013816:Thermodynamics; D013874:Thiopental / Q000032:analysis*; D014867:Water
D011409:Propylene Glycols; D014867:Water; D013874:Thiopental