title: Effects of melengestrol acetate on reproduction in the Beagle bitch.
abstract: Melengestrol acetate orally given to bitches at dose levels of 200 mug or more each day effectively inhibited estrous activity for a treatment period of 243 days and a lapsed period of more than 400 days from the preceding estrous period. The 100-mug dose of the drug, given orally once a day, starting immediately after the bitches were bred or late in gestation, had no effect on conception, pregnancy, or parturition. Gestation was prolonged in bitches given melengestrol acetate starting 1 day after breeding. Drug-polymeric implants blocked reproductive activity, and the progestogen induced cystic endometrial hyperplasia.
mesh_terms: D000818:Animals; D000831:Animals, Newborn; D001724:Birth Weight; D004285:Dogs / Q000502:physiology*; D004971:Estrus / Q000187:drug effects; D005260:Female; D007743:Labor, Obstetric / Q000187:drug effects; D008297:Male; D008552:Melengestrol Acetate / Q000008:administration & dosage / Q000494:pharmacology*; D011245:Pregnadienes / Q000494:pharmacology*; D011247:Pregnancy; D011270:Pregnancy, Animal / Q000187:drug effects; D012098:Reproduction / Q000187:drug effects*
chemical_list: D011245:Pregnadienes; D008552:Melengestrol Acetate