Effects of levamisole on the ultrastructure of mitochondria in the liver of Beagle dogs.
Purebred Beagle dogs were treated daily for 6 days with levamisole in oral doses of 10 mg/kg body weight. Liver biopsies taken before and after treatment showed no ultrastructural differences. Intramitochondrial paracrystalline inclusions before, as well as after, the drug administration were rare. Other minor abnormalities, in a few mitochondria, were as frequent before as after the drug treatment.
D000818:Animals; D004285:Dogs / Q000033:anatomy & histology; D005260:Female; D007978:Levamisole / Q000494:pharmacology*; D008297:Male; D008930:Mitochondria, Liver / Q000187:drug effects* / Q000648:ultrastructure
D007978:Levamisole