Polymorphism of erythromycin studied by differential thermal analysis.
The polymorphism of erythromycin has been studied by differential thermal analysis. Three main forms, two crystalline (I and SI) and one amorphous have been characterized. Solvation and imbibition water can be differentiated. Solvates from 2-propanol (SII), trichloromethane (SIII) and tetrachloromethane (SIV) have been characterized. The physical stability of the various forms both in the dry state and in aqueous suspension are discussed.
D055598:Chemical Phenomena; D002627:Chemistry, Physical; D003460:Crystallization; D004355:Drug Stability; D004917:Erythromycin / Q000032:analysis*; D013055:Spectrophotometry, Infrared; D013535:Suspensions; D013696:Temperature; D013816:Thermodynamics
D013535:Suspensions; D004917:Erythromycin