title: [Immunization of ewes against experimental Brucella melitensis infection: comparison of eleven vaccines].
abstract: A comparative study of 11 antibrucellic vaccines has been carried out in the Limousin region of 360 ewe-lambs divided into groups of 30, a 12th group serving as control. After being vaccinated at 8 months, the ewe-lambs were covered between 9 1/2 and 10 1/2 months, then infected at 11 months with Br. melitensis strain 53 H 38 by instillation of 4 x 10(6) germs on the conjonctiva. Six of these vaccines reduced the number of abortions and the excretion of brucella at parturition: three consisted of an inactivated suspension of a virulent S strain of Br. melitensis in oily adjuvant, another consisted of an inactivated suspension of a modified non-agglutinogenic strain of Br. melitensis also in oily adjuvant, the fifth was prepared from Br. melitensis H 105 and Br. abortus B 112 with saponin and the sixth from a strain of Br. melitensis modified with aluminium hydroxide as adjuvant.
mesh_terms: D000034:Abortion, Veterinary / Q000517:prevention & control; D000276:Adjuvants, Immunologic; D000818:Animals; D000907:Antibodies, Bacterial / Q000096:biosynthesis; D002002:Brucella / Q000276:immunology*; D002004:Brucella Vaccine; D002006:Brucellosis / Q000276:immunology / Q000517:prevention & control / Q000662:veterinary*; D003168:Complement Fixation Tests; D005260:Female; D006386:Hemagglutination Tests; D011247:Pregnancy; D012756:Sheep; D012757:Sheep Diseases / Q000517:prevention & control*; D014611:Vaccination
chemical_list: D000276:Adjuvants, Immunologic; D000907:Antibodies, Bacterial; D002004:Brucella Vaccine
vernacular_title: Immunisation de la brebis contre l'infection expérimentale à Brucella melitensis: comparison de onze vaccins