title: Mammalian toxicity of helenalin, the toxic principle of Helenium microcephalum CD (smallhead sneezeweed).
abstract: Studies with smallhead sneezeweed (Helenium microcephalum DC) indicated that a sesquiterpene lactone, helenalin, is the only significant toxic constituent present. The oral median lethal dose of helenalin for 5 mammalian species was between 85 and 105 mg/kg.
mesh_terms: D000818:Animals; D006224:Cricetinae; D007783:Lactones / Q000633:toxicity*; D051379:Mice; D010936:Plant Extracts / Q000633:toxicity*; D010947:Plants, Toxic; D011817:Rabbits; D051381:Rats; D012717:Sesquiterpenes / Q000633:toxicity*; D045789:Sesquiterpenes, Guaiane; D012756:Sheep; D012757:Sheep Diseases / Q000139:chemically induced
chemical_list: D007783:Lactones; D010936:Plant Extracts; D012717:Sesquiterpenes; D045789:Sesquiterpenes, Guaiane; C001329:helenalin