Platelets, acute inflammation and inflammatory mediators.
The anti-inflammatory activity of aspirin-like drugs could derive, at least in part, by inhibiting synthesis and release of prostaglandins or rabbit aorta-contracting substance from platelets. Indeed, aggregation of platelets and the consequent release of inflammatory mediators has been frequently evoked as a factor in the development of the inflammatory reaction. The participation of platelets in acute inflammation was tested in three types of trauma in rats rendered thrombocytopenic with anti-platelet serum. Oedema in response to carrageenin, anti-platelet serum or passive cutaneous anaphylaxis was no different from the controls in thrombocytopenic rats.
D000208:Acute Disease; D000818:Animals; D001792:Blood Platelets / Q000276:immunology / Q000502:physiology*; D002351:Carrageenan; D004487:Edema / Q000097:blood; D007106:Immune Sera; D007249:Inflammation / Q000503:physiopathology*; D010047:Ovalbumin; D010323:Passive Cutaneous Anaphylaxis; D051381:Rats; D013921:Thrombocytopenia / Q000097:blood
D007106:Immune Sera; D002351:Carrageenan; D010047:Ovalbumin