[Reversal of the pressor effect of PGF2alpha in the rat (author's transl)].
In normal rats, prostaglandin F2alpha is a potent vasoconstrictor. The corresponding systemic hypertension is progressively attenuated by tachyphylaxis, revealing a longlasting fall of blood pressure. Tachyphylaxis is accelerated by previous injection of arachidonic acid and bradyskinin. The vasodepressive activity of PGF2alpha is inhibited by indomethacin.
D000818:Animals; D001095:Arachidonic Acids / Q000494:pharmacology; D001794:Blood Pressure / Q000187:drug effects*; D001920:Bradykinin / Q000494:pharmacology; D007213:Indomethacin / Q000494:pharmacology; D011458:Prostaglandins E / Q000494:pharmacology; D011460:Prostaglandins F / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D051381:Rats; D013618:Tachyphylaxis
D001095:Arachidonic Acids; D011458:Prostaglandins E; D011460:Prostaglandins F; D001920:Bradykinin; D007213:Indomethacin
Sur l'inversion de l'action hypertensive de la prostaglandine F2alpha, chez le rat