[Cancer risk of the stomach resected for ulcer. The role of duodenogastric reflux (author's transl)].
The purpose of this study was to find whether the reflux of bile and pancreatic juices following stomach resection (duodenogastric reflux) enhances the incidence of carcinomas near the gastroenteric anastomosis. 72 male Wistar rats were subjected to stomach resection. The gastroenteric anastomosis (GE) was performed either as short loop anastomosis (Billroth II; n = 39), thus providing a continuous duodenogastric reflux, or as Y-shaped GE (according to Roux; n = 33). By the latter technique, bile and pancreatic juices are derived quantitatively into the jejunum without coming into contact with the remaining part of the stomach. During a period of 33 weeks, operated rats as well as intact animals were given the carcinogen N-methyl-N'-nitro-N-nitrosoguanidine (NG; 120 mg/l) in the drinking water. At autopsy, 33 to 36 weeks after daily oral administration of NG, most of the tumours were found in operated rats undergoing continuous reflux (Billroth II group). In contrast to these findings, the incidence or carcinomas was significantly lower in animals without reflex (Roux group or intact control rats).-The results of our experiments demonstrate that, in rats, the duodenogastric reflux contributes substantially to the development of carcinomas of the resected stomach.
D000230:Adenocarcinoma / Q000473:pathology; D000818:Animals; D001646:Bile; D005743:Gastrectomy / Q000009:adverse effects; D005764:Gastroesophageal Reflux / Q000150:complications*; D009374:Neoplasms, Experimental / Q000139:chemically induced; D009604:Nitrosoguanidines; D010189:Pancreatic Juice; D051381:Rats; D013274:Stomach Neoplasms / Q000209:etiology* / Q000473:pathology
D009604:Nitrosoguanidines
Das Krebsrisiko im Resektionsmagen. Zur Bedeutung des duodenogastrischen Refluxes bei verschiedenen gastroenteralen Anastomosen.