Indolic tryptophan metabolism in uraemia.
Tryptophan and some indolic metabolites were studied in urine, plasma and dialysate of uraemic patients using thin-layer- and high-pressure liquid chromatography. Some new metabolites: indole-3-carboxylic acid, indole-3-carbaldehyde, indolelactic acid and N-acetyltryptophan were detected. Levels of the latter two metabolites in urine, dialysate and especially plasma suggest increased transamination of tryptophan and a possible defect in renal amino acid acylase in uraemia.
D000447:Aldehydes / Q000378:metabolism; D002264:Carboxylic Acids / Q000378:metabolism; D002851:Chromatography, High Pressure Liquid; D002855:Chromatography, Thin Layer; D006801:Humans; D007211:Indoles / Q000378:metabolism*; D007668:Kidney / Q000201:enzymology; D007676:Kidney Failure, Chronic / Q000378:metabolism; D014364:Tryptophan / Q000031:analogs & derivatives / Q000378:metabolism*; D014511:Uremia / Q000378:metabolism*
D000447:Aldehydes; D002264:Carboxylic Acids; D007211:Indoles; C012382:indole-3-carboxylic acid; C012381:indole-3-carbaldehyde; D014364:Tryptophan