[The effect of specific immunization and BCG vaccine on the growth of Krebs-2 ascitic tumor in mice].
Immunization of CC57Br mice with irradiated Krebs-2 carcinoma cells renders no influence on the rate of ascites aggravation in subsequent transplantation of the tumor but increases considerably life-terms of tumor-bearing animals. Immunization with tumor cells in combination with not high doses of BCG results in a reverse development of ascites in some mice and a complete disappearance of tumor in them. With increased dosage of the vaccine the number of animals with ascites regression is increased, but their life-terms are reduced due to reactivation of the tumor process and, presumably, to the development of autoimmune lesions.
D000818:Animals; D001500:BCG Vaccine; D002287:Carcinoma, Krebs 2 / Q000517:prevention & control*; D005260:Female; D051379:Mice; D009368:Neoplasm Transplantation; D010534:Peritoneal Neoplasms / Q000517:prevention & control
D001500:BCG Vaccine
Vliianie spetsificheskoĭ immunizatsii i vaktsiny BTsZh na rost astsitnoĭ opukholi Krebs-2 u mysheĭ