[A preliminary study on the changes of calcium (Ca) and phosphorus (P) contents in serum following intravenous administration of lead acetate (author's transl)].
We investigated the mechanisms of interaction between lead acetate (Pb-Ac) and bone minerals. One hundred and eighteen male rats were used and the following experiments were carried out: (1) determination of changes in serum Ca and P following intravenous injection of Pb-Ac or sodium acetate(Na-Ac) as the control for acetate, (2) to ascertain the deposition of lead at the calcifying site of bone immediately after Pb-Ac administration. The serum Ca and P levels increased with time after Pb-Ac administration and the maximum values were noted after 1 hour in Ca (17 mg%) and 30 minutes in P (13.5mg%), respectively. Both Ca and P levels reverted to the normal range within 12 hours. The net increasing rates in both Ca and P were calculated from each value in the Pb-Ac and Na-Ac groups. Those maximum rates were found immediately after the Pb-Ac administration (0 approximately 30 sec). At the same time, deposition of lead was evident at the calcifying site of bone and insicor dentine.
D000818:Animals; D001842:Bone and Bones / Q000378:metabolism; D002118:Calcium / Q000097:blood*; D006651:Histocytochemistry; D007275:Injections, Intravenous; D007854:Lead / Q000008:administration & dosage / Q000097:blood / Q000378:metabolism / Q000494:pharmacology*; D008297:Male; D010758:Phosphorus / Q000097:blood*; D051381:Rats; D012964:Sodium / Q000494:pharmacology; D013997:Time Factors
D010758:Phosphorus; D007854:Lead; D012964:Sodium; D002118:Calcium