The effect of amino acid restricted diets on the clearance of 125I-labelled polyvinyl pyrrolidone in mice.
Impaired overall phagocytic function, as measured by clearance of radio-labelled polyvinyl pyrrolidone from the blood (KPVP), has been demonstrated in mice whose dietary intake of the essential amino acids phenylalanine and tryptophan was reduced to less than a quarter of that in a standard diet which supported optimal growth. This was associated with loss in weight of body, liver, spleen and thymus and an increase in the phagocytic index, alphaPVP.
D000596:Amino Acids / Q000097:blood / Q000172:deficiency*; D000818:Animals; D001835:Body Weight; D004032:Diet; D005260:Female; D008099:Liver / Q000033:anatomy & histology; D008264:Macrophages / Q000276:immunology*; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D009929:Organ Size; D010587:Phagocytosis; D010649:Phenylalanine / Q000172:deficiency; D011205:Povidone / Q000378:metabolism*; D013154:Spleen / Q000033:anatomy & histology; D013950:Thymus Gland / Q000033:anatomy & histology; D014364:Tryptophan / Q000172:deficiency
D000596:Amino Acids; D010649:Phenylalanine; D014364:Tryptophan; D011205:Povidone