title: Genetic factors in the development of atheroma and on serum total cholesterol levels in inbred mice and their hybrids.
abstract: There is a consistent genetic relationship between the development of atheromata in the aortic sinus wall and serum total cholesterol levels using inbred strains of male mice. This relationship is dependent on a multifactorial (polygenic) type of inheritance that is more complicated than the simple additive-dominance model. There is no special maternal or paternal influence on serum total cholesterol levels or on the development of atheromata.
mesh_terms: D000818:Animals; D001158:Arteries / Q000473:pathology; D001161:Arteriosclerosis / Q000235:genetics* / Q000473:pathology; D002784:Cholesterol / Q000097:blood*; D003433:Crosses, Genetic; D004036:Diet, Atherogenic; D005260:Female; D005796:Genes; D006937:Hypercholesterolemia / Q000235:genetics*; D008297:Male; D051379:Mice; D008808:Mice, Inbred CBA; D008815:Mice, Inbred Strains
chemical_list: D002784:Cholesterol