Segregation analysis of thalassemia in Ferrara.
Segregation analysis of 996 families in which the gene for beta-thalassemia was segregating showed no distortion of expected Mendelian ratios. No appreciable frequency of sporadic cases was detected. It was suggested that segregation distortion is not a mechanism which contributes to the maintenance of polymorphism in the beta-thalassemia system in the population of the Ferrara area.
D003201:Computers; D003433:Crosses, Genetic; D005260:Female; D006579:Heterozygote; D006801:Humans; D007558:Italy; D008297:Male; D011995:Recombination, Genetic; D013223:Statistics as Topic; D013789:Thalassemia / Q000235:genetics*