Influence of lipophilic substances on fungal infections of the human skin. I. What constitutes a good lipid extractant?
A three-factor factorial experiment was performed to assess the efficiency of lipid extraction from the back of human volunteers. Chloroform-methanol (2:1 v/v) proved substantially superior to acetone or diethyl ether. The latter two solvents were also significantly more efficient than n-hexane. The implication of the findings is discussed with regard to the isolation and characterization of fungistatic and bacteriostatic agents on the surface of the skin.
D000473:Alkanes; D000704:Analysis of Variance; D002725:Chloroform; D003881:Dermatomycoses / Q000378:metabolism*; D004986:Ether; D006801:Humans; D008055:Lipids / Q000032:analysis*; D008297:Male; D012867:Skin / Q000032:analysis*; D012997:Solvents
D000473:Alkanes; D008055:Lipids; D012997:Solvents; D004986:Ether; D002725:Chloroform