title: [Nonspecific cell-mediated immunity in chronic hepatitis studied in vitro].
abstract: A considerable damage of immunogenesis with involving both humoral and cellular immunity was recently established in certain forms of chronic hepatitis. The investigation of nonspecific cellular immunity of following-up the transformation activity of lymphocytes in vitro in stimulation with PHA provides data for the inhibition of that immunity in chronic agressive hepatitis with manifestations of hypersplenia. In the progress of the disease, the increase or decrease of the transformation activity of lymphocytes correspond to the improvement or deterioration of the disease. After splenectomy transformation activity of lymphocytes is increased parallelly with the favourable effect as regards the basic ailment and the hematological indices.
mesh_terms: D000328:Adult; D001772:Blood Cell Count; D001798:Blood Proteins / Q000032:analysis; D002478:Cells, Cultured; D002908:Chronic Disease; D005260:Female; D006505:Hepatitis / Q000276:immunology* / Q000628:therapy; D006801:Humans; D007111:Immunity, Cellular / Q000187:drug effects; D066298:In Vitro Techniques; D037102:Lectins / Q000494:pharmacology; D007958:Leukocyte Count; D008213:Lymphocyte Activation / Q000187:drug effects; D008214:Lymphocytes / Q000187:drug effects / Q000276:immunology; D008297:Male; D008875:Middle Aged; D013156:Splenectomy; D013997:Time Factors
chemical_list: D001798:Blood Proteins; D037102:Lectins
vernacular_title: Nespetsifichen kletuchno-oposredstvuvan imunnitet pri niakoi khronichni khepatiti, izsledvan in vitro