Immunocompetence and spontaneous regression of metastatic renal cell carcinoma.
Spontaneous remission of pulmonary metastases from renal cell carcinoma was correlated with a positive response to dinitrochlorobenzene (DNCB). When first seen, the patient was DNCB negative and a chest radiograph showed nodular densities in the right lung and left midlung. Six months after sensitization, the patient had a positive response to DNCB and no evidence of lung metastases. Three mo later, the patient developed brain metastases although X-ray examination showed no pulmonary nodules. A diminished response to DNCB noted over the next several months and chest X ray verified the return of pulmonary metastases.
D000230:Adenocarcinoma / Q000276:immunology*; D001932:Brain Neoplasms / Q000276:immunology; D004137:Dinitrochlorobenzene / Q000276:immunology; D006801:Humans; D007680:Kidney Neoplasms / Q000276:immunology*; D008175:Lung Neoplasms / Q000276:immunology; D008297:Male; D008875:Middle Aged; D009362:Neoplasm Metastasis; D009365:Neoplasm Regression, Spontaneous; D012882:Skin Tests
D004137:Dinitrochlorobenzene