Distressing side-effects of minocycline hydrochloride.
Minocycline hydrochloride is a tetracycline derivative that has been advocated as the drug of choice in the treatment of meningococcal carriers. Recently, we studied a group of 30 patients who experienced a large number of side-effects after receiving minocycline for treatment of meningococcal meningitis. Twenty-seven of 30 (90%) suffered from dizziness, vertigo, ataxia, weakness, nausea, and vomiting. These symptoms appeared within the first 72 hours of taking minocycline, and disappeared within 48 hours of stopping the medication.
D000328:Adult; D001259:Ataxia / Q000139:chemically induced; D002648:Child; D005260:Female; D006801:Humans; D008297:Male; D008585:Meningitis, Meningococcal / Q000517:prevention & control*; D008911:Minocycline / Q000008:administration & dosage / Q000009:adverse effects*; D009325:Nausea / Q000139:chemically induced; D013754:Tetracyclines / Q000009:adverse effects*; D014717:Vertigo / Q000139:chemically induced; D014839:Vomiting / Q000139:chemically induced
D013754:Tetracyclines; D008911:Minocycline