title: Suppression and control of experimentally induced procine coccidiosis with chlortetracycline combination, buquinolate, and lincomycin hydrochloride.
abstract: Weaned pigs were divided into nonmedicated control and medicated principal groups and 3 days later were exposed to infective oocysts comprised of mixed species of swine origin. In separate experiments, a chlortetracycline combination (plus sulfamethazine and penicilin), buquinolate, or lincomycin was administered prophylactically to the principals, starting 3 days before they were exposed to infection, and then was evaluated for efficacy against the experimental exposures. Comparisons between control and principal groups were made on the basis of fecal oocyst counts, fecal consistencies, and body weight gains. On the basis of oocyst counts, both chlortetracycline combination and buquinolate minimized the development of coccidial populations in groups given medicated feed; nonmedicated controls discharged substantial numbers of oocysts. Lincomycin medication was not effective in pigs given 111 mg/kg of feed; it was effective at dose levels of 330 mg/kg of feed and at 22 mg/kg body weight, intramuscularly. Medicated principals always gained more weight on the average than did their infected nonmedicated controls during the experiments. The data on oocyst production support the position that the 3 compounds can function as coccidiostats in swine.
mesh_terms: D000818:Animals; D002751:Chlortetracycline / Q000008:administration & dosage / Q000627:therapeutic use*; D003048:Coccidiosis / Q000469:parasitology / Q000517:prevention & control / Q000662:veterinary*; D004359:Drug Therapy, Combination; D005243:Feces / Q000469:parasitology; D006912:Hydroxyquinolines / Q000627:therapeutic use*; D008034:Lincomycin / Q000627:therapeutic use*; D013552:Swine; D013553:Swine Diseases / Q000469:parasitology / Q000517:prevention & control*
chemical_list: D006912:Hydroxyquinolines; D008034:Lincomycin; D002751:Chlortetracycline