Results of the first 1000 radioreceptorassays for the determination of human chorionic gonadotropin: a new, rapid, reliable, and sensitive pregnancy test.
One thousand radioreceptorassays for human chorionic gonadotropin (hCG) for the diagnosis of pregnancy were analyzed under eight categories. The high sensitivity (50 pg/ml) and specificity, coupled with performance time of the assay (1 hour), provided a new modality for the early diagnosis and management of normal and abnormal pregnancy in the first trimester. The radioreceptorassay becomes positive 1 week after conception. In the normal pregnancy this assay has been 100% correct at the time of the first missed menses. All ectopic pregnancies demonstrated positive tests, and no false negatives occurred. On the other hand, a negative assay excluded ectopic pregnancy.
D000027:Abortion, Incomplete / Q000175:diagnosis; D000818:Animals; D002822:Choriocarcinoma / Q000175:diagnosis; D006063:Chorionic Gonadotropin / Q000097:blood*; D005069:Evaluation Studies as Topic; D005260:Female; D006801:Humans; D008593:Menopause; D010061:Ovulation Detection; D011247:Pregnancy; D011258:Pregnancy Tests / Q000379:methods*; D011271:Pregnancy, Ectopic / Q000175:diagnosis; D011869:Radioligand Assay; D013045:Species Specificity
D006063:Chorionic Gonadotropin