[Mechanism of the antianginal action of nonachlazine].
Experimental data on the mechanism accounting for the action of a new antianginal drug nonachlazine are presented. Nonachlazine was found to intensively (120+/-9.5 per cent) and protractedly (30--40 min) augment the blood flow in the coronary vessels, increasing the oxygen reserve of the myocardium. The contractile function of the heart and beat ejection considerably gain in their intensity, after an initial short-lived fall (by an average of 26.5+/-3.4 per cent), with the resistance of the coronary vessels declining (21+/-1.0 per cent). Administration of nonachlazine made against the background of a propranol (0.5 mg/kg) block of the beta-adrenergic structures of that by practolol (5 mg/kg) is not accompanied by the above effects. The prevalent influence of nonachlazine on the blood circulation and the function of the heart muscle may be explained by its action on the extravascular factors of the venous blood flow regulation (changes in the metabolism activity of the heart, caused by the stimulation of the beta-adrenergic structures of the myocardium).
D000787:Angina Pectoris / Q000188:drug therapy*; D000818:Animals; D002415:Cats; D009200:Myocardial Contraction / Q000187:drug effects*; D009206:Myocardium / Q000378:metabolism*; D010101:Oxygen Consumption / Q000187:drug effects; D010640:Phenothiazines / Q000494:pharmacology / Q000627:therapeutic use*; D010879:Piperazines / Q000494:pharmacology / Q000627:therapeutic use; D014665:Vasodilator Agents / Q000494:pharmacology / Q000627:therapeutic use*
D010640:Phenothiazines; D010879:Piperazines; D014665:Vasodilator Agents
K mekhanizmu antianginal'nogo deĭstviia nonakhlazina