Metabolism of catechol estrogen by human erythrocytes.
In a study designed to evaluate the kinetics of catechol estrogen formation from plasma estrone in vivo, we obtained evidence that the red blood cell (RBC) enzyme, catechol-O-methyl transferase, catalyzes the transformation of 2-hydroxyestrone to 2-methoxyestrone. Under in vitro conditions, the rate of conversion of 2-hydroxyestrone to 2-methoxyestrone by human RBC's was such that 7 nmol of 2-methoxyestrone were formed per h per ml of RBC.
D002394:Catechol O-Methyltransferase / Q000378:metabolism*; D004912:Erythrocytes / Q000201:enzymology*; D004970:Estrone / Q000097:blood / Q000378:metabolism*; D005260:Female; D006801:Humans; D006894:Hydroxyestrones / Q000097:blood / Q000378:metabolism; D066298:In Vitro Techniques; D008297:Male
D006894:Hydroxyestrones; D004970:Estrone; D002394:Catechol O-Methyltransferase