Identification and quantitative GLC determination of iproniazid in human urine.
A GLC method for the specific identification and quantitation of iproiazid, a potent monamine oxidase inhibitor drug, is described. The free drug isolated from urine samples by two-phase extraction reinforced with salting out. Identification and quantitative determination at the microgram level are done on aliquots of the chloroform extract by GLC, using the 2-butyl analog as an internal standard. Iproniazid and potentially interfering compounds present in the extracts are also identified by GLC-mass spectrometry and TLC for supporting evidence of the GLC method's specificity.
D000368:Aged; D002849:Chromatography, Gas; D002855:Chromatography, Thin Layer; D005260:Female; D006801:Humans; D007490:Iproniazid / Q000627:therapeutic use / Q000652:urine*; D008297:Male; D013058:Mass Spectrometry; D001523:Mental Disorders / Q000188:drug therapy; D008875:Middle Aged; D013997:Time Factors
D007490:Iproniazid