Emetic and refusal activity of deoxynivalenol to swine.
The minimum emetic dose of deoxynivalenol to swine weighing 9 to 10 kg was 0.05 mg/kg of body weight intraperitoneally and 0.1 to 0.2 mg/kg orally. There was no emesis by undosed pigs consuming vomitus from pigs orally dosed with deoxynivalenol or penned with such pigs without access to vomitus. Analysis by gas-liquid chromatography of a sample of Gibberella zeae-infected corn containing about 25% visually damaged kernels indicated 12 ppm of deoxynivalenol. Deoxynivalenol added to feed reduced feed consumption of 20- to 45-kg pigs, ranging from a 20% decrease with 3.6 ppm to 90% reduction with 40 ppm. Loss in weight was associated with feed refusal. Feed refusal, however, was much greater for naturally infected corn samples than for feeds with equal concentrations of the pure compound added, indicating the involvement of an additional factor(s) in the swine refusal response.
D000818:Animals; D001835:Body Weight; D004305:Dose-Response Relationship, Drug; D005247:Feeding Behavior / Q000187:drug effects*; D005506:Food Contamination; D005874:Gibberella / Q000302:isolation & purification; D012717:Sesquiterpenes / Q000633:toxicity*; D013552:Swine; D014255:Trichothecenes / Q000633:toxicity*; D014839:Vomiting / Q000139:chemically induced*; D003313:Zea mays / Q000382:microbiology
D012717:Sesquiterpenes; D014255:Trichothecenes; C007262:deoxynivalenol