title: Adamantane and protoadamantanealkanamines as potential anti-Parkinson agents.
abstract: The synthesis of 2-halo-1-adamantanemethanamines, 4-protoadamantanemethanamines, and 4-protoadamantaneamines is described. The anti-Parkinson activity of these amines in terms of reversal of reserpine-induced catalepsy in rats has been evaluated and compared with amantadine. 2-Bromo- and 2-chloro-1-adamantanemethanamines are shown to be twice as active as amantadine.
mesh_terms: D000218:Adamantane / Q000031:analogs & derivatives / Q000138:chemical synthesis* / Q000494:pharmacology / Q000633:toxicity; D000588:Amines / Q000138:chemical synthesis / Q000494:pharmacology / Q000633:toxicity; D000818:Animals; D000978:Antiparkinson Agents / Q000138:chemical synthesis* / Q000633:toxicity; D001831:Body Temperature / Q000187:drug effects; D001952:Bridged-Ring Compounds / Q000138:chemical synthesis*; D007928:Lethal Dose 50; D051379:Mice; D009043:Motor Activity / Q000187:drug effects; D051381:Rats; D012110:Reserpine / Q000037:antagonists & inhibitors
chemical_list: D000588:Amines; D000978:Antiparkinson Agents; D001952:Bridged-Ring Compounds; D012110:Reserpine; D000218:Adamantane