Effect of maternally administered heroin on the motor activity of rat offspring.
The behavioral of 21-day old rats whose mothers were administered heroin (5 mg/kg daily) throughout gestation and lactation was studied utilizing an activity wheel, activity cage, open field test, and step-down latency times from an elevated platform. The total score of all behavioral tasks of offspring from heroin-injected females was statistically different from that of pups from saline-injected mothers, with heroin-treated animals appearing more active.
D000818:Animals; D001724:Birth Weight / Q000187:drug effects; D005260:Female; D003932:Heroin / Q000494:pharmacology*; D008431:Maternal-Fetal Exchange; D009043:Motor Activity / Q000187:drug effects*; D011247:Pregnancy; D051381:Rats; D013997:Time Factors
D003932:Heroin