title: Results of a two year chronic toxicity study with hexachlorobutadiene in rats.
abstract: Lifetime ingestion by rats of 0.2 mg/kg/day of hexachlorobutadiene caused no discernible ill effects. Slight degrees of primarily renal toxicity occurred with 2 mg/kg/day; 20 mg/kg/day caused multiple toxic effects, including renal tubular neoplasms.
mesh_terms: D000230:Adenocarcinoma / Q000139:chemically induced; D000236:Adenoma / Q000139:chemically induced; D000818:Animals; D001835:Body Weight / Q000187:drug effects; D002070:Butadienes / Q000008:administration & dosage / Q000633:toxicity*; D003306:Coproporphyrins / Q000652:urine; D004032:Diet; D005260:Female; D007668:Kidney / Q000187:drug effects / Q000473:pathology; D007680:Kidney Neoplasms / Q000139:chemically induced*; D007684:Kidney Tubules; D008297:Male; D009369:Neoplasms / Q000209:etiology; D009929:Organ Size / Q000187:drug effects; D051381:Rats
chemical_list: D002070:Butadienes; D003306:Coproporphyrins