Nonspecific effect of bis(2-ethylhexyl) phthalate on hexobarbital sleep time.
The data presented suggest that the intravenous or intraperitoneal administration of bis(2-ethylhexyl) phthalate prolongs hexobarbital sleep time in mice and rats by enlarging the lipophilic pool, a phenomenon that can be replicated by pretreatment of the animals with olive oil. These results call attention to the importance of considering the physical characteristics of a substance when evaluating its effect on a pharmacologically active agent.
D000818:Animals; D006591:Hexobarbital / Q000097:blood / Q000378:metabolism / Q000494:pharmacology*; D008099:Liver / Q000378:metabolism; D008297:Male; D051379:Mice; D010795:Phthalic Acids / Q000494:pharmacology*; D051381:Rats; D012890:Sleep / Q000187:drug effects*; D013997:Time Factors
D010795:Phthalic Acids; D006591:Hexobarbital