Testosterone and the sex difference in blood pressure in mice.
Blood pressure of adult male SWR/J mice is approximately 20 mm Hg higher than that of females. Castrating males at weaning eliminated this sex difference. Testosterone restored blood pressure of castrated mice to the level of the intact males within 10 days indicating a pressor effect of testosterone. Ovariectomy had no effect on blood pressure.
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects*; D001835:Body Weight / Q000187:drug effects; D004343:Drug Implants; D005260:Female; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D012737:Sex Factors; D013737:Testis / Q000502:physiology; D013739:Testosterone / Q000008:administration & dosage / Q000494:pharmacology*
D004343:Drug Implants; D013739:Testosterone