Naloxone-reversible peripheral electroanalgesia in intact and spinal rats.
Peripheral electrical stimulation of the rat produced a "dose-dependent" analgesia both in intact and in spinal animals. Naloxone, a narcotic antagonist, almost completely reversed this analgesia. It is felt that peripheral electroanalgesia acts via the release of endogenous narcotic-like substances, the enkephalins, at spinal and supraspinal centres.
D000698:Analgesia / Q000379:methods*; D000818:Animals; D004560:Electricity; D008297:Male; D009020:Morphine / Q000494:pharmacology; D009270:Naloxone / Q000494:pharmacology*; D051381:Rats; D013116:Spinal Cord / Q000502:physiology
D009270:Naloxone; D009020:Morphine