Effect of chain length on critical micelle formation and protein binding of quaternary ammonium compounds.
The micelle formation tendency (log 1/CMC)) of a series of alkyldimethylbenzylammonium compounds is shown to be linearly dependent on the alky chain length, indicating no curling of the side chain up to C19. Protein binding of these charged molecules on the primary binding site for sulfaethiodole is shown to be parabolically dependent on the chain length with an optimal chain length around C16.
D001665:Binding Sites; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D003102:Colloids; D007700:Kinetics; D008823:Micelles; D011485:Protein Binding; D000644:Quaternary Ammonium Compounds / Q000378:metabolism*; D012044:Regression Analysis; D012710:Serum Albumin, Bovine / Q000378:metabolism; D013329:Structure-Activity Relationship
D003102:Colloids; D008823:Micelles; D000644:Quaternary Ammonium Compounds; D012710:Serum Albumin, Bovine