Enzyme induction by oral testosterone.
Six normal male volunteers ingested a dose of 400 mg free testosterone daily as tablets over 21 days. By the end of treatment intravenous antipyrine half-life had decreased significantly from 8.0 +/- 2.7 to 5.7 +/- 2.6 hr. The subjects eliminated testosterone from serum more rapidly on the twenty-first day of testosterone ingestion than on the first day. Serum albumin, bilirubin, prothrombin, alanine-amino-transferase, and alkaline phosphatases were unchanged during the experiment. It is concluded that oral testosterone treatment induces the hepatic drug-metabolizing system including that of testosterone.
D000284:Administration, Oral; D000328:Adult; D000983:Antipyrine / Q000097:blood; D003864:Depression, Chemical; D004790:Enzyme Induction / Q000187:drug effects*; D006207:Half-Life; D006801:Humans; D008111:Liver Function Tests; D008297:Male; D013739:Testosterone / Q000008:administration & dosage / Q000378:metabolism / Q000494:pharmacology*; D013997:Time Factors
D013739:Testosterone; D000983:Antipyrine