Potential antitumor agents. 17. 9-Anilino-10-methylacridinium salts.
9-Anilino-10-methylacridinium salts result from reaction of substituted anilines and 9-chloro-10-methylacridinium salts in turn prepared from the 10-methyl-9(10H)-acridones and SOCl2 or POCl3. Antileukemic (L1210) activities of the quaternary salts were uniformly depressed compared to their unquaternized counterparts. If drug-solvent partition properties (log P) of the cations were considered, log P-activity relationships were similar for both base and quaternary salt series. Substituent effects on antitumor activity were similar in both series.
D000166:Acridines / Q000138:chemical synthesis* / Q000627:therapeutic use; D000814:Aniline Compounds / Q000138:chemical synthesis / Q000627:therapeutic use; D000818:Animals; D000970:Antineoplastic Agents / Q000138:chemical synthesis*; D007939:Leukemia L1210 / Q000188:drug therapy; D051379:Mice; D008809:Mice, Inbred C3H; D008811:Mice, Inbred DBA; D000644:Quaternary Ammonium Compounds / Q000138:chemical synthesis / Q000627:therapeutic use; D013329:Structure-Activity Relationship
D000166:Acridines; D000814:Aniline Compounds; D000970:Antineoplastic Agents; D000644:Quaternary Ammonium Compounds