[Effectiveness of the inhalatory administration of chlolincocin in experimental staphylococcal pneumonia].
Administration of chlolincocin (7-chlor-7-desoxylincomycin) in the form of inhalation aerosol to albino mice in a dose of 200 Units/mouse provided the drug therapeutic concentrations in the lung tissue. The antibiotic was well adsorbed and detected in the blood, liver, kidneys and other biological substrates. Penetration of chlolincocin and lincomycin from the lungs into the blood was better in healthy animals. In animals with experimental staphylococcal infection their blood levels were 1.5--2 times lower. Repeated inhalations of chlolincocin resulted in an increase resulted in its levels in the lung tissue up to 8--10 Units/ml, however, its blood levels increased insignificantly. When chlolincocin and lincomycin were administered intravenously, their concentrations in the lung tissue were lower and detected for a shorter period of time than after the inhalation administration. The aerosols of chlolincocin markedly inhibited the growth of Staph. aureus in the lungs. The drug was 3--5 times more active than lincomycin. Inhalation administration of chlolincocin aerosol is supposed to be expedient for the treatment of inflammatory diseases of the respiratory organs caused by lincomycin sensitive flora.
D000818:Animals; D001682:Biological Availability; D002981:Clindamycin / Q000627:therapeutic use*; D004353:Drug Evaluation, Preclinical; D007275:Injections, Intravenous; D008034:Lincomycin / Q000008:administration & dosage; D008168:Lung / Q000382:microbiology; D051379:Mice; D008815:Mice, Inbred Strains; D011023:Pneumonia, Staphylococcal / Q000188:drug therapy*; D012138:Respiratory Therapy; D013211:Staphylococcus aureus / Q000302:isolation & purification
D002981:Clindamycin; D008034:Lincomycin
Effektivnost' ingaliatsionnogo vvedeniia khlolinkomitsina pri éksperimental' noĭ stafilokkovoĭ pnevmonii