Serum and glomerular complement in 205 cases of glomerulonephritis.
In 205 cases of GN the glomerular deposits of C3, C1q, C4, and C3A and the serum levels of the same complement components at the time of biopsy were studied. Alterations of serum complement profile were found only in acute GN, membranoproliferative GN and lupus nephritis, while glomerular deposition was observed with a different incidence and intensity in all nephropathies. A strict correlation between the intensity of deposits and the degree of hypocomplementaemia was found only in early acute GN and in active lupus nephritis.
D003172:Complement C1 / Q000378:metabolism; D003176:Complement C3 / Q000378:metabolism; D003181:Complement C4 / Q000378:metabolism; D003165:Complement System Proteins / Q000378:metabolism*; D004792:Enzyme Precursors / Q000378:metabolism; D005921:Glomerulonephritis / Q000276:immunology*; D006801:Humans; D007678:Kidney Glomerulus / Q000276:immunology; D008180:Lupus Erythematosus, Systemic / Q000150:complications; D009393:Nephritis / Q000209:etiology / Q000276:immunology; D012712:Serum Globulins / Q000378:metabolism
D003172:Complement C1; D003176:Complement C3; D003181:Complement C4; D004792:Enzyme Precursors; D012712:Serum Globulins; D003165:Complement System Proteins