The relationship between hydrocortisone acetate distribution and efficacy in inflamed eyes: continuous vs intermittent delivery.
Hydrocortisone acetate was administered to rabbit eyes intermittently in 250mug doses (given twice daily or once hourly) or continuously at 10mug/hr from an experimental ocular therapeutic system. Tissue drug distribution was measured over a 1 to 4 day period in experimental conjunctivitis. Anti-inflammatory efficacy was evaluated over a 4 day period in the same model. Statistically significant improvement in inflammation was observed 48 hours after initiation of continuous delivery treatment and after 4 days of the twice daily eyedrop regimen. Drug uptake by ocular tissues correlated with drug efficacy. Continuous delivery at 10mug/hr produced conjunctival steriod concentrations exceeding 1mug/g during 8 through 24 hours of treatment, and average levels of 1mug/g from days 2 through 4. Conjunctival steroid concentations generally did not exceed 1mug/g in eyedrop treated eyes until the fourth treatment day, when their clinical improvement matched that observed in the continuously treated eyes.
D000287:Administration, Topical; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000378:metabolism* / Q000627:therapeutic use; D003228:Conjunctiva / Q000378:metabolism; D003231:Conjunctivitis / Q000188:drug therapy*; D005123:Eye / Q000378:metabolism*; D006854:Hydrocortisone; D007908:Lens, Crystalline / Q000378:metabolism; D009883:Ophthalmic Solutions; D011817:Rabbits; D012590:Sclera / Q000378:metabolism; D013997:Time Factors
D000893:Anti-Inflammatory Agents; D009883:Ophthalmic Solutions; D006854:Hydrocortisone