Intraventricular 6-hydroxydopamine lowers isolation-induced fighting behavior in male mice.
Male mice with high isolation-induced fighting tendencies were administered 200 mug 6-OHDA or vehicle intraventricularly and tested for fighting tendency for up to 10 weeks until sacrifice, and assayed for brain NE levels. A strong correlation was found between NE depletion and reduced fighting tendency after 6-OHDA treatment. The depressed fighting by mice with less than 200 ng. NE/g persisted throughout a series of test fights, indicating no recovery in fighting behavior throughout the survival time.
D000374:Aggression / Q000187:drug effects*; D000818:Animals; D001923:Brain Chemistry / Q000187:drug effects; D004298:Dopamine / Q000032:analysis; D005260:Female; D006801:Humans; D006892:Hydroxydopamines / Q000008:administration & dosage / Q000494:pharmacology*; D007276:Injections, Intraventricular; D008297:Male; D051379:Mice; D009638:Norepinephrine / Q000032:analysis; D012934:Social Isolation
D006892:Hydroxydopamines; D004298:Dopamine; D009638:Norepinephrine