Ribostamycin, as an intermediate in the biosynthesis of neomycin.
A mutant of a neomycin-producting Streptomyces fradiae was found which synthesizes ribostamycin instead of neomycin. After a reverse mutation new colonies were obtained producting neomycin again. Ribostamycin might thus be considered as an intermediate in the biosynthesis of neomycin.
D000900:Anti-Bacterial Agents / Q000096:biosynthesis*; D001419:Bacteria / Q000187:drug effects; D005285:Fermentation; D009154:Mutation; D009355:Neomycin / Q000096:biosynthesis* / Q000494:pharmacology; D012271:Ribostamycin / Q000096:biosynthesis*; D013302:Streptomyces / Q000378:metabolism*
D000900:Anti-Bacterial Agents; D012271:Ribostamycin; D009355:Neomycin