[Parameters of the elimination of phenolsulfonphthaleine (phenolred) in children (author's transl)].
The elimination of phenol-red was examined in 124 children without renal diseases. The normal values of the kinetic parameters were determined after intravenous injection of 3-4 mg dye per kg bodyweight. The elimination-half-life, which is independent from bodyweight and length was used as measure for the renal tubular secretion. In newborns (85,8 min) and young infants up to the age of 6 months (25,4 min) elimination-half-lives were longer than in older ones. After the second year of life (19,7 min) normal values of adults could be determined. The total clearance of phenol-red is smaller in newborns (185 ml/kg/h) than in children older than one year (643 ml/kg/h). Prematures had a longer elimination-half-life and a smaller total clearance than mature newborns.
D000367:Age Factors; D001827:Body Height; D001835:Body Weight; D002675:Child, Preschool; D005919:Glomerular Filtration Rate; D006207:Half-Life; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007234:Infant, Premature; D007275:Injections, Intravenous; D010635:Phenolphthaleins / Q000378:metabolism*; D010637:Phenolsulfonphthalein / Q000378:metabolism* / Q000652:urine
D010635:Phenolphthaleins; D010637:Phenolsulfonphthalein
Kinetische Parameter der Phenolrotelimination beim Kind