Fasting (acute energy deprivation) in man: effect on blood coagulation and fibrinolysis.
Blood coagulation and fibrinolysis parameters were studied during 10 days of total fasting in healthy, normal weight males. A reduction of plasma levels of factor VIII activity with a concomitant decrease in factor VIII antigen was found, without other laboratory evidence for a disseminated intravascular coagulation. The effect of 10 days' starvation on blood coagulation appears to be small but the effect of more prolonged starvation might implicate impaired hemostasis.
D000328:Adult; D000941:Antigens / Q000032:analysis; D001777:Blood Coagulation; D004211:Disseminated Intravascular Coagulation / Q000150:complications; D005169:Factor VIII / Q000378:metabolism*; D005338:Fibrin Fibrinogen Degradation Products / Q000378:metabolism; D005340:Fibrinogen / Q000378:metabolism; D005342:Fibrinolysis; D006487:Hemostasis; D006801:Humans; D008297:Male; D013217:Starvation / Q000097:blood*
D000941:Antigens; D005338:Fibrin Fibrinogen Degradation Products; D005169:Factor VIII; D005340:Fibrinogen