title: Pharmacokinetic model for serum concentrations of ampicillin in the newborn infant.
abstract: The time course of ampicillin concentrations in the sera of three newborn infants during and upon termination of intravenous infusion at a constant rate can be described by a two-compartment pharmacokinetic model. The parameters of the model were determined by simultaneously fitting the serum concentration data obtained during and after the infusion by means of a nonlinear regression program with the aid of a digital computer. The half-life of ampicillin in the infants ranged from 2.1 to 2.9 hr; these values are more than twice those observed in adults with normal renal function.
mesh_terms: D000667:Ampicillin / Q000097:blood*; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D008954:Models, Biological; D011247:Pregnancy
chemical_list: D000667:Ampicillin