title: Intracisternal virus-like particles in brain of a multiple sclerosis patient.
abstract: Doughnut-shaped particles, 55-65 nm in diameter, were revealed by electron microscopy in the cisterns of the rough endoplasmic reticulum of cells from an active lesion in autopsied brain tissue from a multiple sclerosis patient. The morphology of the particles closely resembled that of coronaviruses.
mesh_terms: D000328:Adult; D001921:Brain / Q000648:ultrastructure*; D003332:Coronaviridae / Q000648:ultrastructure*; D005260:Female; D006801:Humans; D009103:Multiple Sclerosis / Q000209:etiology / Q000382:microbiology / Q000473:pathology*