Failure to induce hepatic pathology in animals sensitized to a halothane metabolite and subsequently challenged with halothane.
The results of this animal study confirm the induction of delayed hypersensitivity to a halothane metabolite, but the sensitization does not cause hepatic damage on subsequent halothane exposures. Before the hypothesis that hepatic necrosis following halothane has an immunologic basis can be accepted or rejected, more critical studies with different approaches must be made.
D000818:Animals; D056486:Chemical and Drug Induced Liver Injury / Q000209:etiology* / Q000276:immunology; D004195:Disease Models, Animal; D005260:Female; D005463:Fluoroacetates / Q000009:adverse effects*; D006221:Halothane / Q000009:adverse effects* / Q000276:immunology; D006501:Hepatic Encephalopathy / Q000139:chemically induced / Q000276:immunology; D006968:Hypersensitivity, Delayed / Q000276:immunology; D008099:Liver / Q000187:drug effects*; D008297:Male; D012882:Skin Tests; D014269:Trifluoroacetic Acid / Q000009:adverse effects*
D005463:Fluoroacetates; D014269:Trifluoroacetic Acid; D006221:Halothane