Delta 9-Tetrahydrocannabinol, ethanol, and amphetamine as discriminative stimuli-generalization tests with other drugs.
Three groups of rats (A, B, C) were trained in a T-maze discriminate between drug-and control solution-induced internal discriminative stimuli. The drugs used to induce discriminative stimuli were: delta 9-THC, 5.0 mg/kg (Group A); ethanol, 1.2 g/kg (Group B), and amphetamine, 1.0 mg/kg(Group C). After discrimination acquisition several drugs were tested for generalization in each group. Group A was tested with delta 8-THC, CBD, CBN, ethanol, pentobarbital,chlorpromazine, amphetamine, and apomorphine; only delta8-THC and CBN induced delta9-THC-like responses. Group B was tested with delta 9-THC, delta 8-THC, CBD, CBN, pentobarbital, and amphetamine; pentobarbital induced ethanol-like response. Group C was tested with delta 9-THC, apomorphine, and ethanol; delta 9-THC and apomorphine elicited amphetamine-like responses.
D000818:Animals; D002185:Cannabidiol / Q000494:pharmacology; D002188:Cannabis / Q000494:pharmacology*; D003463:Cues; D003913:Dextroamphetamine / Q000494:pharmacology*; D004192:Discrimination, Psychological; D013759:Dronabinol / Q000494:pharmacology*; D000431:Ethanol / Q000494:pharmacology*; D005795:Generalization, Stimulus / Q000187:drug effects*; D008297:Male; D051381:Rats
D002185:Cannabidiol; D000431:Ethanol; D013759:Dronabinol; D003913:Dextroamphetamine