Reduction of amphotericin B nephrotoxicity with mannitol.
Amphotericin B in combination with mannitol was given to a patient who had mucocutaneous candidiasis and moderate renal insufficiency. Previously, amphotericin B alone had induced an abrupt increase in serum creatinine and urea nitrogen, but when mannitol was given concurrently there was no worsening of renal function. Thus, amphotericin B with mannitol appears to offer a less nephrotoxic but equally candicidal therapeutic regimen in the renal compromised patient requiring parenteral candicidal therapy.
D000293:Adolescent; D000328:Adult; D000666:Amphotericin B / Q000009:adverse effects* / Q000037:antagonists & inhibitors / Q000627:therapeutic use; D002177:Candidiasis / Q000150:complications / Q000188:drug therapy; D002648:Child; D002675:Child, Preschool; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007668:Kidney / Q000187:drug effects*; D008353:Mannitol / Q000494:pharmacology* / Q000627:therapeutic use; D009395:Nephritis, Interstitial / Q000150:complications; D009397:Nephrocalcinosis / Q000150:complications; D012874:Skin Diseases, Infectious / Q000188:drug therapy; D014165:Transfer Factor / Q000008:administration & dosage
D014165:Transfer Factor; D008353:Mannitol; D000666:Amphotericin B