Inhibition of lactation in rabbits by 2-Br-alpha-Ergokryptine-mesilate (CB154).
The lactating rabbit responds to single injections of the inhibitor of prolactin secretion 2-Br-alpha-ergokryptine-mesilate (CB 154) by a reversible reduction in milk yield, which is dose-dependent. Inhibition of galactopoiesis by CB 154 is also observed in rats, dogs, pigs and in woman, but not in goats and cattle. This points to a difference in prolactin dependence of galactopoiesis in the two groups.
D000818:Animals; D000831:Animals, Newborn / Q000254:growth & development; D001835:Body Weight / Q000187:drug effects; D001971:Bromocriptine / Q000494:pharmacology*; D003864:Depression, Chemical; D004305:Dose-Response Relationship, Drug; D004873:Ergolines / Q000494:pharmacology*; D005260:Female; D007408:Intestinal Absorption / Q000187:drug effects; D007774:Lactation / Q000187:drug effects*; D008892:Milk / Q000378:metabolism; D008893:Milk Ejection / Q000187:drug effects; D011247:Pregnancy; D011388:Prolactin / Q000378:metabolism; D011817:Rabbits; D013045:Species Specificity
D004873:Ergolines; D001971:Bromocriptine; D011388:Prolactin