title: Amniotic fluid lecithin/sphingomyelin ratio changes related to centrifugal force.
abstract: Lecithin/sphingomyelin ratio (L/S ratio) in amniotic fluid has gained wide clinical acceptance as an index of fetal lung maturity. We determined L/S ratios of amniotic fluids centrifuged at various "g-forces." Our studies demonstrate that the L/S ratio value is highly dependent on the g-force used to prepare the fluid. We recommend standardization of the g-force, time, and temperature used in preparation of the amniotic fluid for L/S ratio determination.
mesh_terms: D000653:Amniotic Fluid / Q000032:analysis*; D002498:Centrifugation; D005188:False Negative Reactions; D005189:False Positive Reactions; D005260:Female; D005865:Gestational Age; D006112:Gravitation; D006801:Humans; D007231:Infant, Newborn; D008168:Lung / Q000196:embryology; D010713:Phosphatidylcholines / Q000032:analysis*; D011247:Pregnancy; D011296:Prenatal Diagnosis; D012127:Respiratory Distress Syndrome, Newborn / Q000175:diagnosis; D013109:Sphingomyelins / Q000032:analysis*
chemical_list: D010713:Phosphatidylcholines; D013109:Sphingomyelins