Sister chromatid exchange in dyskeratosis congenita lymphocytes.
Sister chromatid exchange (SCE) frequency in chromosomes from lymphocytes of a patient with dyskeratosis congenita was 12-2 per mitosis. Our 33 normal controls had a mean of 5-4 SCE per mitosis and 5 patients with Fanconi's anaemia averaged 7-6 SCE per mitosis. The rate of chromosome breakage was only 0-5% in the dyskeratosis congenita patient and 0 to 2-5% in controls, while the Fanconi's anaemia patients showed higher values.
D002842:Chromatids; D002877:Chromosomes, Human; D003434:Crossing Over, Genetic; D005199:Fanconi Anemia / Q000097:blood; D006801:Humans; D008214:Lymphocytes / Q000648:ultrastructure; D008297:Male; D009264:Nails, Malformed; D010198:Pancytopenia / Q000151:congenital; D010859:Pigmentation Disorders / Q000151:congenital*; D012871:Skin Diseases / Q000151:congenital*; D013577:Syndrome