[Reaction of peripheral veins and arteries following administration of beta-active agents. Studies on isoproterenol, propranolol, and practolol].
The local effect on veins and arteries of isoprenaline, propranolol and practolol was investigated in the human after intra-arterial application at the forearm. The injection of isoprenaline was followed by a dilatation of the arteries and veins. This effect was inhibited by propranolol, but not by practolol. The results demonstrate, that the peripheral vasoactive beta-stimulatory effect is mediated by so-called beta2-receptors, which were not influenced by a selective beta1-blocking agent like practolol. The results were discussed in respect to their clinical relevance.
D000328:Adult; D001808:Blood Vessels / Q000187:drug effects*; D001993:Bronchodilator Agents; D004347:Drug Interactions; D005260:Female; D005542:Forearm / Q000098:blood supply; D006801:Humans; D007545:Isoproterenol / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D008297:Male; D008875:Middle Aged; D011217:Practolol / Q000009:adverse effects / Q000494:pharmacology*; D011433:Propranolol / Q000494:pharmacology*; D011941:Receptors, Adrenergic / Q000187:drug effects*; D012039:Regional Blood Flow / Q000187:drug effects
D001993:Bronchodilator Agents; D011941:Receptors, Adrenergic; D011433:Propranolol; D007545:Isoproterenol; D011217:Practolol
Die Reaktion der arteriellen und venösen Gefässperipherie auf beta-aktive Substanzen. Untersuchungen mit Isoproterenol, Propranolol und Practolol