Inhibitory effect of decidua on fibrinolysis induced by urokinase and by the fibrinolytic activity of the rat ovum.
With the use of a technique, which permits the study of fibrinolytic enzymes and inhibitors in organ culture, human decidua was found to produce inhibitors capable of inhibiting plasminogen activation induced by urokinase as well as activators released from kidney explants. Also the medium in which rat and human decidua had been cultured was found to inhibit fibrinolytic activity of the rat ovum. The inhibitors emanating from the decidua are presumably of importance for facilatating the implantation of ova.
D000818:Animals; D003470:Culture Media; D003656:Decidua / Q000378:metabolism*; D003864:Depression, Chemical; D010450:Endopeptidases / Q000494:pharmacology*; D005260:Female; D005337:Fibrin / Q000378:metabolism; D005340:Fibrinogen / Q000378:metabolism; D005342:Fibrinolysis / Q000187:drug effects; D006801:Humans; D007668:Kidney / Q000378:metabolism; D009924:Organ Culture Techniques; D010063:Ovum / Q000378:metabolism*; D010958:Plasminogen / Q000378:metabolism; D011247:Pregnancy; D051381:Rats; D014568:Urokinase-Type Plasminogen Activator / Q000494:pharmacology*
D003470:Culture Media; D005337:Fibrin; D005340:Fibrinogen; D010958:Plasminogen; D010450:Endopeptidases; D014568:Urokinase-Type Plasminogen Activator