title: Hydrolysis of carbon-labeled cocaine in human serum.
abstract: Hydrolysis of 14C-cocaine in human serum, separation of the metabolites on TLC, and subsequent identification on GLC is described. AT 1 H, 20 percent of the cocaine was metabolized to benzoylecgonine, ecgonine and ecgonine methylester. At this time interval the highest percent of product was in the form of the ecogonine methyl ester, a metabolite not previously reported in humans. After 4 h, 67 percent of the cocaine was hydrolyzed; of this, 45 percent was benzoylecgonine and ecgonine in a ratio of 1.6 to 1. The half-life for cocaine hydrolyzed in human serum was approximately 2.5 h.
mesh_terms: D003042:Cocaine / Q000031:analogs & derivatives / Q000097:blood*; D006207:Half-Life; D006801:Humans; D006868:Hydrolysis; D066298:In Vitro Techniques; D013997:Time Factors
chemical_list: D003042:Cocaine