title: Skeletal uptake of 99mTc-diphosphonate in relation to local bone blood flow.
abstract: The right/left ratios of tibial uptake of 99mTc-diphosphonate (EHDP) and relative blood flow (based on microsphere distribution) were determined in control rats and rats with a ligated right femoral artery or a healing right tibial fracture. Correlation between 99mTc-EHDP uptake and relative blood flow was highly significant (r=0.917; P less than 0.0001) for relative flow ratios less than 1.7. When the ratio was greater than 1.7, there was little further increase in 99mTc-EHDP uptake. Ligation of the femoral artery in rats with healing fractures resulted in a more marked reduction of blood flow than of 99mTc-EHDP uptake. These results suggest that regional bone blood flow is a major determinant of 99mTc-EHDP uptake, though changes in regional tracer extraction efficiency are also important.
mesh_terms: D000818:Animals; D001842:Bone and Bones / Q000098:blood supply / Q000378:metabolism*; D005263:Femoral Artery / Q000601:surgery; D008297:Male; D051381:Rats; D012039:Regional Blood Flow; D013667:Technetium / Q000378:metabolism*; D013978:Tibial Fractures / Q000503:physiopathology
chemical_list: D013667:Technetium