Identification of 10, 11-epoxide and other cyclobenzaprine metabolites isolated from rat urine.
Cyclobenzaprine (40 mg/kg ip) was administered to rats, and six urinary metabolites of this drug were identified. They were the 10, 11-epoxide, the N -oxide, the desmethyl derivative, the hydroxylated and desmethylhydroxylated compounds, and the N-oxide hydroxylated at the 10- or 11-position. Mass spectrometric analysis confirmed their structures.
D000639:Amitriptyline / Q000031:analogs & derivatives; D000818:Animals; D002849:Chromatography, Gas; D003986:Dibenzocycloheptenes / Q000378:metabolism / Q000652:urine*; D004852:Epoxy Compounds / Q000138:chemical synthesis / Q000652:urine*; D004988:Ethers, Cyclic / Q000652:urine*; D005966:Glucuronidase; D006868:Hydrolysis; D066298:In Vitro Techniques; D008297:Male; D013058:Mass Spectrometry; D008862:Microsomes, Liver / Q000378:metabolism; D051381:Rats
D003986:Dibenzocycloheptenes; D004852:Epoxy Compounds; D004988:Ethers, Cyclic; D000639:Amitriptyline; C004704:cyclobenzaprine; D005966:Glucuronidase