Isolation of 10, 11-epoxide of protriptyline in rat urine after protriptyline administration.
The 10, 11-epoxide, 10-hydroxy, and 10, 11-dihydrodiol metabolites of protriptyline were identified in rat urine collected after the administration of 40 mg/kg ip of protriptyline. Mass spectrometric characterization confirmed the structure of these metabolites.
D000818:Animals; D002849:Chromatography, Gas; D002855:Chromatography, Thin Layer; D003986:Dibenzocycloheptenes / Q000031:analogs & derivatives*; D004852:Epoxy Compounds / Q000652:urine; D005966:Glucuronidase; D006868:Hydrolysis; D008297:Male; D013058:Mass Spectrometry; D011530:Protriptyline / Q000031:analogs & derivatives* / Q000652:urine; D051381:Rats
D003986:Dibenzocycloheptenes; D004852:Epoxy Compounds; D011530:Protriptyline; D005966:Glucuronidase