5-Hydroxytryptamine extraction by the lung.
Both 5-hydroxytryptamine and norepinephrine are removed from blood during a single passage through the pulmonary vasculature of the dog; 5-hydroxytryptamine is removed to a greater degree than is norepinephrine. The magnitude of extraction of both 5-hydroxytryptamine and norepinephrine is similar to that previously determined in man. In the intact dog, imipramine inhibits the uptake of 5-hydroxytryptamine by the lung in a dose-dependent manner.
D000818:Animals; D002250:Carbon Radioisotopes; D004285:Dogs; D004305:Dose-Response Relationship, Drug; D007099:Imipramine / Q000494:pharmacology; D008168:Lung / Q000378:metabolism*; D009638:Norepinephrine / Q000097:blood; D012701:Serotonin / Q000097:blood*; D014316:Tritium
D002250:Carbon Radioisotopes; D014316:Tritium; D012701:Serotonin; D007099:Imipramine; D009638:Norepinephrine