Apomorphine self-injection is not affected by alpha-methylparatyrosine treatment: support for dopaminergic reward.
Pretreatment with AMPT at doses which markedly altered the self-injection or amphetamine did not affect the self-injection of apomorphine. These data support the idea that the self-injection of apomorphine is produced via the direct activation of dopamine receptors rather than by the release of either norepinephrine or dopamine.
D000661:Amphetamine / Q000008:administration & dosage; D000818:Animals; D001058:Apomorphine / Q000008:administration & dosage*; D003216:Conditioning, Operant / Q000187:drug effects*; D004298:Dopamine; D005260:Female; D008781:Methyltyrosines / Q000494:pharmacology*; D051381:Rats; D011955:Receptors, Drug / Q000187:drug effects*; D012055:Reinforcement Schedule; D012201:Reward; D013997:Time Factors
D008781:Methyltyrosines; D011955:Receptors, Drug; D000661:Amphetamine; D001058:Apomorphine; D004298:Dopamine