Pharmacokinetic approach to the clinical use of lidocaine intravenously.
The time course of lidocaine plasma concentrations following various modes of administration were predicted by computer. Initiating therapy with a single intravenous bolus dose was unsatisfactory; plasma levels during the first hour were potentially toxic after a 200-mg bolus and subtherapeutic after a 50- to 100-mg bolus. After two bolus doses of 100 mg, separated by 20 to 30 minutes, or a rapid loading infusion over 15 to 60 minutes, therapeutic concentrations were achieved and maintained. Pharmacokinetic principles can be of value in devising rational approaches to lidocaine dosage.
D001145:Arrhythmias, Cardiac / Q000188:drug therapy; D006801:Humans; D007263:Infusions, Parenteral; D007275:Injections, Intravenous; D007700:Kinetics; D008012:Lidocaine / Q000008:administration & dosage* / Q000097:blood / Q000633:toxicity; D008433:Mathematics; D008962:Models, Theoretical; D013997:Time Factors
D008012:Lidocaine