Thrombocytopoiesis in W/Wv mice.
W/Wv mice are genetically anemic, but usually have normal numbers of circulating granulocytes and platelets. An intrinsic stem cell defect has been suggested by numerous experiments, and a reduced number of megakaryocytes has been found in the bone marrow. Platelet production in W/Wv mice and +/+ litter mate controls was studied by measurement of the incorporation of 75Se-methionine (SeM) into platelets after intravenous injection of 2 muCi of SeM. Mean incorporation of SeM into platelets of W/Wv mice was 17 per cent greater than that of +/+ controls at 66 hours. Mean platelet counts of W/Wv mice were not different from controls. Recovery from thrombocytopenia resulted in a greater proportion of labeled platelets in W/Wv mice, and a slight delay in recovery of the platelet count. These results suggest that W/Wv mice have a normal overall rate of thrombopoiesis despite having a decreased megakaryocyte mass.
D000748:Anemia, Macrocytic / Q000235:genetics / Q000378:metabolism / Q000662:veterinary; D000818:Animals; D001772:Blood Cell Count; D001792:Blood Platelets / Q000378:metabolism*; D005838:Genotype; D006400:Hematocrit; D006410:Hematopoiesis; D008297:Male; D008715:Methionine / Q000378:metabolism; D051379:Mice; D008815:Mice, Inbred Strains; D013921:Thrombocytopenia / Q000378:metabolism
D008715:Methionine