[The effect of oxytocin and dihydrostilbestrol on various uterine cations (author's transl)].
The effect of dihydrostilbestrol diacetate and oxytocin on the Na+, K+, Ca++ and Mg++ content in uterine Wistar rats has been studied. A bilateral ovariectomy on the animals was performed. After seven days dihydrostibestrol (0.25 mg/kg a day) and oxytocine (0.025 U.I./kg a day) were administered separately and simultaneously i.p. during a period of five days. Twenty four hours after the first, third and fifth administration, five rats from each group were decapited and the above uterine cation content was determined by atomic absorption spectrometry. Dihydrostibestrol induced a marked increase and a slight decrease in K+ and Na+ contents respectively, lowering the Na/K ration. It also increased greatly Ca++ and Mg++ content. Oxytocin induced a Na+ and K+ increase, a Ca++ decrease, and slight changes in Mg++. These results partially confirmed the bioelectric and biomechanic alterations produced by the above hormones on the uterine cells.
D000818:Animals; D004573:Electrolytes / Q000032:analysis* / Q000378:metabolism; D005260:Female; D006589:Hexestrol / Q000494:pharmacology*; D010121:Oxytocin / Q000494:pharmacology*; D051381:Rats; D013268:Stimulation, Chemical; D014599:Uterus / Q000032:analysis / Q000378:metabolism*
D004573:Electrolytes; D006589:Hexestrol; D010121:Oxytocin
Efecto de la oxitocina y dihidroestilbestrol sobre el contenido uterino de diversos cationes