The inhibitory effect of vitamin E on desferrioxamine-induced iron excretion in rats.
The influence of vitamin E on the mobilization and excretion of storage iron induced by DF was studied in normal and iron-overloaded rats. Vitamin E administration in pharmacologic doses resulted in complete inhibition of the effect of DF on storage iron in iron-overloaded rats while no such effect could be demonstrated in rats with normal iron stores. The mechanism of the observed inhibition of DF action by vitamin E is at present unknown. Nevertheless this drug interaction has to be considered in view of ongoing therapeutic trials where both antioxidants and iron chelating drugs are administered simultaneously to thalassemic patients with transfusion induced iron overload.
D000818:Animals; D003676:Deferoxamine / Q000037:antagonists & inhibitors / Q000494:pharmacology* / Q000627:therapeutic use; D005260:Female; D005293:Ferritins / Q000378:metabolism; D007501:Iron / Q000097:blood / Q000378:metabolism* / Q000652:urine; D008099:Liver / Q000378:metabolism; D051381:Rats; D013154:Spleen / Q000378:metabolism; D013789:Thalassemia / Q000628:therapy; D014810:Vitamin E / Q000494:pharmacology* / Q000627:therapeutic use
D014810:Vitamin E; D005293:Ferritins; D007501:Iron; D003676:Deferoxamine