title: Studies on the effect of tobacco smoke on the biotransformation of vasoactive substances in the isolated perfused rabbit lung. I. Prostaglandin F2alpha.
abstract: Cigarette smoke administration was previously found to have a pronounced  inhibitory effect on metabolism of nicotine and benzo[a]pyrene in the isolated perfused rabbit lung. These observations suggest the possibility of tobacco smoke inhibition of biotransformations associated with non-ventilatory pulmonary functions such as metabolic clearance of endogenous vasoactive substances. However, studies of the effect of smoke on uptake and metabolism of PGF2alpha in isolated perfused rabbit lungs provide no evidence of inhibition of these processes.
mesh_terms: D000818:Animals; D001711:Biotransformation; D006207:Half-Life; D066298:In Vitro Techniques; D008168:Lung / Q000378:metabolism*; D008297:Male; D010477:Perfusion; D011460:Prostaglandins F / Q000378:metabolism*; D011817:Rabbits; D012907:Smoking / Q000378:metabolism*; D013997:Time Factors
chemical_list: D011460:Prostaglandins F