title: [Purpura fulminans associated with varicella and polyvalent protective inoculations (author's transl)].
abstract: We report about a 10 5/12 years old boy, who developed the rare disease of Purpura fulminans following Varicella, after having received the trivalent Poliomyelitis vaccine of Sabin and a diphtheria-tetanus booster during the incubation period of Varicella. The acute stage of the disease was overcome by symptomatic therapy; extensive skin necrosis especially in the lower extremities had to be treated surgically. The etiology of Purpura fulminans has not yet been established. Since diffuse intravascular clotting (DIC) plays an essential part in the pathogenesis of this disease. Heparintherapy is now used as the treatment of choice. At the present state of knowledge we believe that the protective inoculations given in the incubation period of Varicella possibly provoced Purpura fulminans as a rare complication of Varicella.
mesh_terms: D002644:Chickenpox / Q000150:complications*; D002648:Child; D004165:Diphtheria / Q000517:prevention & control; D006493:Heparin / Q000627:therapeutic use; D006801:Humans; D008297:Male; D009336:Necrosis; D011051:Poliomyelitis / Q000517:prevention & control; D011693:Purpura / Q000150:complications* / Q000188:drug therapy; D012871:Skin Diseases / Q000150:complications; D013742:Tetanus / Q000517:prevention & control; D014611:Vaccination / Q000009:adverse effects*
chemical_list: D006493:Heparin
vernacular_title: Purpura fulminans nach Varizellen und polyvalenter Impfung