Histofluorescence studies on the effect of 1,3-dimethyl-5-adamantanamine (D-145) on serotonin neurons in midbrain raphe nuclei.
1,3-Dimethyl-5-adamantanamine (D-145), a dopamine system stimulating agent, given at doses of 10-40 mg/kg ip, 2-5 hr before sacrifice, depressed the intensity of serotonin fluorescence in the rat midbrain raphe nuclei. Spiroperidol, 2 mg/kg ip, given 5 min before D-145, prevented the depression of serotonin fluorescence in the dorsal raphe nucleus (NDR), but not in the other groups of serotonin midbrain neurons. The results suggest a functional interaction between dopaminergic neurons and serotoninergic neurons in NDR.
D000547:Amantadine / Q000031:analogs & derivatives*; D000818:Animals; D002395:Catecholamines / Q000096:biosynthesis; D004298:Dopamine / Q000502:physiology; D005453:Fluorescence; D006651:Histocytochemistry; D008297:Male; D008559:Memantine / Q000494:pharmacology*; D008636:Mesencephalon / Q000187:drug effects*; D009474:Neurons / Q000378:metabolism*; D051381:Rats; D011955:Receptors, Drug / Q000187:drug effects; D012701:Serotonin / Q000378:metabolism*; D013997:Time Factors
D002395:Catecholamines; D011955:Receptors, Drug; D012701:Serotonin; D000547:Amantadine; D004298:Dopamine; D008559:Memantine