Convulsive thresholds and the activity of anticonvulsants in electroseizure test. The role of serotoninergic system.
The effect of different compounds modifying the activity of serotoninergic system on the convulsive threshold and on anticonvulsant action of phenyltoin (PHEN) phenobarbital (PHB), m-bromophenyl succinimide (BPHSI) and acetazolamide (ACA) in electroseizure test was studied. The obtained results suggest that 5-HT plays a significant role in the convulsive threshold and in ACA anticonvulsant action. No correlation, however, was observed between anticonvulsant action of the studied drugs and their influence on 5-HT level in brain.
D000818:Animals; D000927:Anticonvulsants / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D001923:Brain Chemistry / Q000187:drug effects; D004298:Dopamine / Q000378:metabolism; D004597:Electroshock; D006897:Hydroxyindoleacetic Acid / Q000032:analysis; D008297:Male; D051379:Mice; D009638:Norepinephrine / Q000378:metabolism; D011955:Receptors, Drug / Q000187:drug effects; D012640:Seizures / Q000503:physiopathology*; D012701:Serotonin / Q000032:analysis / Q000378:metabolism / Q000502:physiology*
D000927:Anticonvulsants; D011955:Receptors, Drug; D012701:Serotonin; D006897:Hydroxyindoleacetic Acid; D004298:Dopamine; D009638:Norepinephrine