Teratogenicity of adenine arabinoside (Ara-A).
The potentially teratogenic effect of antiviral drugs, particularly when given systemically, prompted the evaluation of the teratogenic effect of Ara-A when given systemically in doses significantly higher than those used clinically. Under the conditions of this study, neither teratogenic nor embryocidal effects of Ara-A were observed.
D000014:Abnormalities, Drug-Induced / Q000209:etiology; D000818:Animals; D011684:Purine Nucleosides / Q000633:toxicity*; D011817:Rabbits; D012272:Ribs / Q000002:abnormalities; D013723:Teratogens; D014740:Vidarabine / Q000633:toxicity*
D011684:Purine Nucleosides; D013723:Teratogens; D014740:Vidarabine