The total eosinophil count in asthmatic children.
The diurnal variation in total eosinophil count (TEC) in asthmatic children not on medications or on thophylline-containing bronchodilators orally every 6 hr is similar to that reported in normal subjects, with a decrease in TEC in the morning and an increase in the evening. Asthmatic children taking prednisone in 8:00 A.M. on alternate days have diurnal variations in TEC on the "day off" prednisone similar to those on normal children. On the "day on" prednisone, administered either on a daily or alternate-day basis, TECs approach zero 4 to 8 hr after prednisone is taken. The TEC then increases in the evening as it does in children not taking prednisone.
D000293:Adolescent; D000628:Aminophylline / Q000627:therapeutic use; D001249:Asthma / Q000097:blood* / Q000188:drug therapy; D002648:Child; D002940:Circadian Rhythm; D004804:Eosinophils; D006801:Humans; D007958:Leukocyte Count; D011239:Prednisolone / Q000627:therapeutic use
D000628:Aminophylline; D011239:Prednisolone