Sea-blue histiocytosis associated with hyperlipidaemia.
A patient with sea-blue histiocytosis in spleen and bone marrow with an accompanying hyperlipidaemia is described. The hyperlipidaemia was due to an increase in "free" cholesterol, lecithin, and triglycerides. Despite these findings lecithin-cholesterol acyl transferase activity was normal. Although the precise biochemical defect was not identified, there was a failure of transport of cholesterol from chylomicrons in vitro. We propose that the sea-blue histiocyte is a marker, in some cases, of abnormal lipid metabolism.
D000328:Adult; D001853:Bone Marrow / Q000648:ultrastructure*; D001854:Bone Marrow Cells; D002784:Cholesterol / Q000097:blood / Q000378:metabolism; D003594:Cytoplasmic Granules; D006644:Histiocytes; D006801:Humans; D006949:Hyperlipidemias / Q000150:complications*; D008074:Lipoproteins / Q000032:analysis; D008297:Male; D013154:Spleen / Q000648:ultrastructure*; D013163:Splenomegaly / Q000150:complications*; D014280:Triglycerides / Q000097:blood
D008074:Lipoproteins; D014280:Triglycerides; D002784:Cholesterol