17beta-ol androgens and free index in hirsute and hirsute obese women.
We have found the mean levels of combined serum testosterone and dihydrotestosterone (T+DHT) and the free index (FI) to be significantly higher and the mean dihydrotestosterone precipitation index (DHT-PI) to be significantly lower in hirsute women than in normal women. Although the mean T+DHT values of the different groups of hirsute patients were comparable, the FI value of the oligomenorrheic and/or obese patient was higher than that of the nonobese, normally menstruating group. In addition, the mean DHT-PI level of obese patients was significantly lower than that of nonobese patients. The lowest androgen binding was found in obese patients with oligomenorrhea. In our experience, hirsutism is associated with T+DHT values of 150 ng/dl or lower. Measurement of androgen binding and androgen levels in unchromatographed serum extracts provides valuable information in the treatment of hirsute women.
D000293:Adolescent; D000328:Adult; D000728:Androgens / Q000097:blood*; D013196:Dihydrotestosterone / Q000097:blood; D005260:Female; D006628:Hirsutism / Q000097:blood*; D006801:Humans; D008875:Middle Aged; D009765:Obesity / Q000097:blood*; D009839:Oligomenorrhea / Q000097:blood; D011233:Precipitin Tests; D013739:Testosterone / Q000097:blood
D000728:Androgens; D013196:Dihydrotestosterone; D013739:Testosterone