title: Hodgkin's disease in American Negroes. Histologic classification of the disease in 143 untreated patients, and age distribution.
abstract: The Rye histologic classification of Hodgkin's disease has been applied to 143 previously untreated cases of Hodgkin's disease in Negro patients seen in four hospitals in Washington, D.C.,during a 16-year period (1959-1974). The frequencies and age distributions of histologic subtypes were compared with those in American and two African series. Those histologic subtypes associated with poor prognoses (mixed-cellularity and lymphocytic depletion) predominated in American Negroes and in Negroes from Ibadan, Nigeria, and Kampala, Uganda. In an American series from Connecticut (approximately 98% Caucasian) the histologic subtypes lymphocytic predominance and nodular sclerosis were preponderant. There were statistically significantly less of the nodular sclerosis subtype (P less than 0.005), and more of the mixed-cellularity subtype in American Negroes compared with the Connecticut series (P less than 0.001). In contrast to findings in predominantly Caucasian populations, there was a predilection of the nodular sclerosis subtype for males in American and in African Negroes. This study showed that Hodgkin's disease in American Negroes epidemiologically corresponds to the so-called "intermediate pattern" of the disease.
mesh_terms: D000293:Adolescent; D000328:Adult; D000349:Africa; D000367:Age Factors; D000368:Aged; D044383:Black People; D002648:Child; D002675:Child, Preschool; D005260:Female; D006680:HLA Antigens; D006689:Hodgkin Disease / Q000453:epidemiology / Q000276:immunology / Q000473:pathology*; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D008875:Middle Aged; D012737:Sex Factors; D014481:United States; D001741:Black or African American
chemical_list: D006680:HLA Antigens