title: The natural history of chronic otitis media.
abstract: A retrospective study was made of 200 chronic otitis media patients. Simple chronic otitis media was observed in 76 per cent of cases; the rest were associated with cholesteatoma. In about one third of the patients, the contralateral ear showed some inflammatory middle ear disease as well. The average time lapse between initial symptoms and hospitalization was about 10 years. The events leading to the tympanic perforation were difficult to ascertain, but included probably acute otitis media, possibly external otitis, trauma, and a rather large group (35-40 per cent) of insidious 'essential perforations'. The aetiology of the 'essential perforations' is so far not known, but might be non-inflammatory in nature but related to insufficient middle ear aeration and hypo-pneumatization as well as to what is termed atelectatic ears. The bacteria isolated from chronic otitis media ears (usually gram negative bacteria and staphylococcus aureus) are usually not the types of micro-organisms found in association with any primary or acute otitis media. It is proposed that the bacterial infection encountered in what is termed 'chronic otitis media' is often a secondary infection of a primary perforated tympanic membrane, the perforation originating or persisting in underventilated ears, and having arisen from various causes--some of them as yet unknown.
mesh_terms: D000293:Adolescent; D000328:Adult; D000367:Age Factors; D002781:Cholesteatoma / Q000150:complications; D002908:Chronic Disease; D004427:Ear Diseases / Q000150:complications; D004432:Ear, Middle; D006801:Humans; D007239:Infections / Q000150:complications; D010033:Otitis Media / Q000150:complications / Q000209:etiology*; D013997:Time Factors