title: [Pathways of corticosteroid biosynthesis in human adrenals (Itsenko-Cushing disease)].
abstract: Pregnenolone and its hydroxyl derivatives are of dominant importance in cortisol and corticosterone synthesis in human adrenals (hyperplasic glands and adenomes) removed in Itsenko-Kushing disease. Progesterone is produced in minimal amounts and is nearly not used for steroidogenesis. Participation of 17,21-dihydroxypregnenolone in cortisol synthesis is demonstrated. 17-hydroxyprogesterone is found not to take an important part as cortisol precursor. 21-hydroxypregnenolone is an essential intermediate in corticosterone synthesis. 11-hydroxyprogesterone does not participate in corticosteroids formation, since the rate of progesterone 11-hydroxylation in human adrenal mitochondria is minimal.
mesh_terms: D000236:Adenoma / Q000378:metabolism; D000305:Adrenal Cortex Hormones / Q000096:biosynthesis*; D000310:Adrenal Gland Neoplasms / Q000378:metabolism; D000311:Adrenal Glands / Q000378:metabolism* / Q000473:pathology / Q000648:ultrastructure; D002784:Cholesterol / Q000378:metabolism; D003480:Cushing Syndrome / Q000378:metabolism*; D006801:Humans; D006965:Hyperplasia; D007700:Kinetics; D008928:Mitochondria / Q000378:metabolism; D011284:Pregnenolone / Q000096:biosynthesis / Q000378:metabolism; D011374:Progesterone / Q000096:biosynthesis / Q000378:metabolism
chemical_list: D000305:Adrenal Cortex Hormones; D011374:Progesterone; D011284:Pregnenolone; D002784:Cholesterol
vernacular_title: Puti biosinteza kortikosteroidov v nadpochechnikakh cheloveka (bolezn' Itsenko--Kushinga)