title: The cholinergic component in the reflex vasodilatation elicited by stimulation of the depressor nerves in the rabbit.
abstract: 1 The effects of the stimulation of the cephalic endings of the depressor nerve on the resistance in the perfused hindlimb were studied in the rabbit. 2 The vasodilatation thus elicited in the perfused hindlimb was reduced either by administration of guanethidine or by sympathectomy and abolished by subsequent treatment with atropine. 3 These data confirm the existence of two components in the genesis of the reflex vasodilatation: a passive component, due to the inhibition of sympathetic discharge, and an active component which in the rabbit is cholinergic in nature.
mesh_terms: D000818:Animals; D001285:Atropine / Q000494:pharmacology; D001794:Blood Pressure / Q000187:drug effects; D004558:Electric Stimulation; D006145:Guanethidine / Q000494:pharmacology; D006614:Hindlimb / Q000502:physiology; D006632:Histamine / Q000494:pharmacology; D008297:Male; D009573:Nitrites / Q000494:pharmacology; D010275:Parasympathetic Nervous System / Q000502:physiology*; D011817:Rabbits; D012018:Reflex; D012039:Regional Blood Flow / Q000187:drug effects; D013564:Sympathetic Nervous System / Q000502:physiology; D014665:Vasodilator Agents / Q000494:pharmacology*
chemical_list: D009573:Nitrites; D014665:Vasodilator Agents; D001285:Atropine; D006632:Histamine; D006145:Guanethidine