[Specific stimulation of the lymphocyte blast transformation reaction in patients with rheumatism under conditions of exposure to delagil, mephenaminic acid and amidopyrine].
Antirheumatic preparations chiefly inhibited (in vitro) the specific microbial stimulation of the reaction of blast transformation of lymphocytes (RBL) in the patients with torpid rheumocarditis caused by addition of streptococcus nucleoproteid into the medium. Specifically stimulated RBL became intensified in healthy donors on addition to the culture medium of amidopyrin and mephenaminic acid; as to delagil, it depressed the specifically stimulated RBL both in healthy donors and in patients.
D000632:Aminopyrine / Q000627:therapeutic use*; D002738:Chloroquine / Q000627:therapeutic use*; D006801:Humans; D008213:Lymphocyte Activation; D009966:Orphenadrine / Q000627:therapeutic use*; D012214:Rheumatic Heart Disease / Q000188:drug therapy* / Q000276:immunology; D013291:Streptococcus / Q000276:immunology
D000632:Aminopyrine; D002738:Chloroquine; D009966:Orphenadrine
Spetsificheskaia stimuliatsiia reaktsii blasttransformatsii limfotsitov u bol'nykh revamtizmom v usloviiakh vozdeĭstviia delagilom, mefaminovoĭ kislotoĭ i amidopirinom