Inhibition of prostaglandin F2alpha-induced reflex bradycardia and hypotension by meclofenamic acid.
Intravenous injection of prostaglandin F2alpha (4-15 mug/kg, i.v.) produces an increase in pulmonary arterial pressure in conjunction with reflex bradycardia and hypotension in the anesthetized cat. Meclofenamic acid (30 mg/kg, i.v.) inhibited the bradycardia and the reflex contribution to the systemic hypotension. Neither the PGF2alpha-induced pulmonary vasoconstriction nor the direct systemic vasodilator actions of PGF2alpha were blocked by meclofenamate. In addition, the reflex responses caused by i.v. veratrine and 5-HT were not inhibited by meclofenamate. These results suggest that meclofenamic acid selectively blocks the afferent mechanism by which PGF2alpha induces reflex bradycardia and hypotension in the cat.
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects*; D002415:Cats; D004305:Dose-Response Relationship, Drug; D005260:Female; D006339:Heart Rate / Q000187:drug effects*; D008297:Male; D008469:Meclofenamic Acid / Q000494:pharmacology*; D011460:Prostaglandins F / Q000008:administration & dosage / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D011651:Pulmonary Artery; D012701:Serotonin / Q000494:pharmacology; D014702:Veratrine / Q000494:pharmacology; D062367:ortho-Aminobenzoates / Q000494:pharmacology*
D011460:Prostaglandins F; D062367:ortho-Aminobenzoates; D012701:Serotonin; D008469:Meclofenamic Acid; D014702:Veratrine