[Deafness due to topical neomycin (author's transl)].
Today neomycin is almost exclusively given as an ointment in combination with other antibiotics, because of its known oto- and nephrotoxicity. Topical application in high dosage can cause ototoxicity as proved by one patient from this clinic. After laryngectomy and neck dissection for an extensive carcinoma of the epiglottis a 2 X 2 cm dehiscent pyocyaneus infected wound was treated daily with neomycin sulphate solution. A total of 30 gm was given over 3 months during which time the patient became deaf neomycin caused the deafness.
D002277:Carcinoma / Q000601:surgery; D003638:Deafness / Q000139:chemically induced*; D005931:Glottis; D006801:Humans; D007822:Laryngeal Neoplasms / Q000601:surgery; D008297:Male; D008875:Middle Aged; D037981:Neck Dissection; D009355:Neomycin / Q000009:adverse effects* / Q000627:therapeutic use; D011183:Postoperative Complications / Q000188:drug therapy; D011552:Pseudomonas Infections / Q000188:drug therapy
D009355:Neomycin
Taubheit nach lokaler Neomycinapplikation