title: The efficacy of intravaginal 15 methyl prostaglandin F2alpha methyl ester in first and second trimester abortion.
abstract: Fifteen methyl prostaglandin F2alpha methyl ester prepared within a silastic device for intravaginal administration appears to be advantageous. This study describes the technique carried out and the results observed in 50 patients. The analogue is prepared in 1.0% and 0.5% delivery systems. Twenty-four patients received the 1.0% dosage schedule and all twenty-four patients aborted. Twenty-six patients received 0.5% and twenty-three patients aborted. The coagulation millieu and other parameters were similar to that reported for other prostaglandins.
mesh_terms: D000028:Abortion, Induced; D003692:Delayed-Action Preparations; D004305:Dose-Response Relationship, Drug; D004341:Drug Evaluation; D005260:Female; D006801:Humans; D010298:Parity; D011247:Pregnancy; D011261:Pregnancy Trimester, First; D011262:Pregnancy Trimester, Second; D011460:Prostaglandins F / Q000008:administration & dosage / Q000009:adverse effects; D012826:Silicone Elastomers; D014590:Uterine Contraction / Q000187:drug effects; D014621:Vagina
chemical_list: D003692:Delayed-Action Preparations; D011460:Prostaglandins F; D012826:Silicone Elastomers