title: Malignant cold thyroid nodules in hyperthyroidism.
abstract: In 65 hyperthyroid patients with a cold nodule a carcinoma was found at operation in 14 cases, i.e. a malignancy incidence of 21-5 per cent. In 859 euthyroid cases with a cold thyroid nodule 104 malignant lesions (12-1 per cent) were found. The difference is statistically significant. Surgery in cases with a cold thyroid nodule is strongly indicated if this occurs in a hyperthyroid gland.
mesh_terms: D000328:Adult; D000367:Age Factors; D000368:Aged; D005260:Female; D006801:Humans; D006980:Hyperthyroidism / Q000150:complications* / Q000601:surgery; D008297:Male; D008875:Middle Aged; D013964:Thyroid Neoplasms / Q000150:complications*