title: Effect of phenylbutazone on the metabolic disposition of warfarin in the dog.
abstract: Phenylbutazone has been shown to modify the physiologic disposition of warfarin in the dog. Dogs pretreated with phenylbutazone for a week, and permitted to remain drug-free for an additional week, eliminated warfarin from plasma 2-3 times faster than non-pretreated controls with an average half-life of 7.8 hours. In-vitro hepatic microsomal metabolism of warfarin and cytochrome P-450 content were greater for hepatic microsomes derived from phenylbutazone pretreated animals.
mesh_terms: D000818:Animals; D004285:Dogs; D005470:Fluorometry; D006207:Half-Life; D008297:Male; D008862:Microsomes, Liver / Q000378:metabolism; D010653:Phenylbutazone / Q000494:pharmacology*; D014859:Warfarin / Q000032:analysis / Q000378:metabolism*
chemical_list: D014859:Warfarin; D010653:Phenylbutazone