GLC determination of doxepin plasma levels.
A procedure is described for extracting doxepin, a tricyclic antidepressant, from plasma and subsequently measuring its concentration by GLC. The developed technique permits the resolution and quantitative determination of the cis- and trans-isomers of doxepin as well as its desmethyl metabolite. The method allows precise, reliable measurement of the drug and one of its metabolities in concentrations as low as 10 ng/ml of plasma.
D000328:Adult; D000368:Aged; D002849:Chromatography, Gas; D003864:Depression, Chemical; D004316:Doxepin / Q000097:blood* / Q000627:therapeutic use; D005260:Female; D006801:Humans; D007536:Isomerism; D008297:Male; D008875:Middle Aged
D004316:Doxepin