Ultrastructure of the stroma of nasal polyps: cilia in stromal fibroblasts.
Ultrastructural examination of the stroma of simple nasal polyps was shown that there is an edematous framework of fibroblasts with abundant interdigitating cytoplasmic processes, a plexus of inflamed blood vessels, and a mixed infiltrate of active inflammatory cells. Solitary cilia were seen to arise from the stromal mesenchymal cells; no mycoplasma or viral inclusions were present. These features may have a relationship to the pathogenesis of nasal polyps. An immunologically induced liberation of vasoactive amines from mast cells results in increased capillary permeability and a consequent excess of intracellular fluid; the stromal cells attempt to check this expansion by an increase in collagen synthesis.
D001485:Basement Membrane / Q000648:ultrastructure; D002196:Capillaries / Q000648:ultrastructure; D002462:Cell Membrane / Q000648:ultrastructure; D002923:Cilia / Q000648:ultrastructure*; D003238:Connective Tissue / Q000648:ultrastructure; D004727:Endothelium / Q000648:ultrastructure; D005347:Fibroblasts / Q000648:ultrastructure*; D006801:Humans; D007365:Intercellular Junctions / Q000648:ultrastructure; D007962:Leukocytes / Q000648:ultrastructure; D009297:Nasal Mucosa / Q000098:blood supply / Q000648:ultrastructure; D009298:Nasal Polyps / Q000098:blood supply / Q000648:ultrastructure*