title: ["De novo substituent constants" in the study of quantitative structure-activity relationship].
abstract: The basic features of the Free-Wilson method for assigning additivity constants to structural features of related compounds is described. The method is presented in considerable operational detail with special emphasis on its development. An original example is discussed. Showing that the substituent  constants can be related to more fundamental physico-chemical substituent parameters such as the hydrophobic constants pi.
mesh_terms: D006801:Humans; D010118:Oxytetracycline / Q000037:antagonists & inhibitors / Q000494:pharmacology; D013211:Staphylococcus aureus / Q000187:drug effects; D013329:Structure-Activity Relationship
chemical_list: D010118:Oxytetracycline
vernacular_title: "De novo substituent constants" nello studio delle correlazioni quantitative struttura chimica-attività biologica