Relevance of dimethylamine to mechanism studies of DIC (DTIC, NSC 45388).
Monolayer cultures of Chinese hamster ovary (CHO) cells take up the photo-decomposition products of DIC more readily than DIC itself. Dimethylamine, an immediate product of this degradative pathway, can ultimately become associated with the DNA, RNA, and protein of the cells as demonstrated by selective enzymatic degradation of macromolecules and isopycnic centrifugation. The relevance of these observations to mechanism studies of DIC is discussed.
D000818:Animals; D002460:Cell Line; D006224:Cricetinae; D004247:DNA; D003606:Dacarbazine / Q000378:metabolism / Q000528:radiation effects; D004123:Dimethylamines / Q000378:metabolism; D008027:Light; D046911:Macromolecular Substances; D014226:Triazenes / Q000378:metabolism
D004123:Dimethylamines; D046911:Macromolecular Substances; D014226:Triazenes; D003606:Dacarbazine; D004247:DNA