Prostatic fluid and tissue concentrations of ampicillin after administration of hetacillin ester (BL-P1761).
Ampicillin concentrations in prostatic fluid and tissue were studied in dogs after constant intravenous infusion of ampicillin (three dogs) and a lipid-soluble methoxymethyl ester of hetacillin, BL-P1761 (six dogs). Prostatic fluid ampicillin concentrations as determined by bioassay were found to be approximately 15 times higher after administration of hetacillin than after a similar amount of ampicillin. The prostatic fluid concentrations after hetacillin ester administration were approximately one-half of the simultaneous plasma concentrations. This hetacillin ester is thus the first penicillin compound shown to be penetrating the blood-prostatic fluid barrier, resulting in clinically relevant prostatic fluid concentrations.
D000667:Ampicillin / Q000097:blood / Q000378:metabolism*; D000818:Animals; D004285:Dogs; D004952:Esters; D006868:Hydrolysis; D008297:Male; D010406:Penicillins / Q000378:metabolism*; D010862:Pilocarpine / Q000494:pharmacology; D011467:Prostate / Q000378:metabolism*; D013268:Stimulation, Chemical
D004952:Esters; D010406:Penicillins; D010862:Pilocarpine; D000667:Ampicillin