Effects of DL-ethionine on mouse liver tRNA base composition.
Treatment of mice with DL-ethionine and adenine causes a reduction of all methylated bases of liver tRNA. This effect is dose-dependent and specific for the methylated bases. Individual methylated components are affected to different extents, m22G being most sensitive to inhibition.
D000225:Adenine / Q000494:pharmacology; D000818:Animals; D004305:Dose-Response Relationship, Drug; D005001:Ethionine / Q000494:pharmacology*; D005260:Female; D008099:Liver / Q000378:metabolism*; D008745:Methylation; D051379:Mice; D008807:Mice, Inbred BALB C; D012343:RNA, Transfer / Q000032:analysis / Q000378:metabolism*; D012263:Ribonucleosides / Q000032:analysis
D012263:Ribonucleosides; D012343:RNA, Transfer; D000225:Adenine; D005001:Ethionine