Cannabinoid induced behavioral convulsions in rabbits.
A population of New Zealand White rabbits has been found to exhibit behavioral convulsions when given low intravenous doses of psychoactive cannabinoids of marijuana. The behavioral convulsions decrease in severity and then disappear after the long-term administration of delta9-tetrahydrocannabinol. The extreme sensitivity of these rabbits to the stimulant action of cannabinoids suggests that the population might serve as a model in studies of the stimulant action of cannabinoids.
D000818:Animals; D002186:Cannabinoids / Q000378:metabolism / Q000633:toxicity; D013759:Dronabinol / Q000633:toxicity*; D004361:Drug Tolerance; D005796:Genes; D011817:Rabbits; D012640:Seizures / Q000139:chemically induced*
D002186:Cannabinoids; D013759:Dronabinol