Structure-activity relationships for homoserine derivatives as inhibitors of the enzymatic synthesis of S-adenosyl-L-methionine.
The adenosyltransferase inhibitory activities of a series of homoserine derivatives were studied using Hansch equations and CNDO/2 calculations. Structure-activity relationships are established involving electronic and lipophilic parameters.
D006714:Homoserine / Q000031:analogs & derivatives*; D008970:Molecular Weight; D012436:S-Adenosylmethionine / Q000037:antagonists & inhibitors / Q000096:biosynthesis*; D013329:Structure-Activity Relationship
D006714:Homoserine; D012436:S-Adenosylmethionine