title: Strain distribution and linkage relationship of a mouse embryonic hemoglobin variant.
abstract: Search for structural variants of three globin chains (x, y, z), synthesized only during mouse embryonic hematopoiesis, was carried out by electrophoretic analysis of blood from 12-day embryos, all with C57BL/6 mothers, and fathers from 115 inbred stocks selected for their diverse genetic origins. Structure of the beta-chains of adult hemoglobins differed among the tested strains, with 57 carrying the Hbbs allele, 56 the Hbbd allele, and two the Hbbp allele. The search revealed no x- or z-chain variants but confirmed and extended knowledge of a previously described y-chain variant. Blood of all embryos sired by males from the 57 Hbbs strains contained only y'-chains, while blood of au embryos sired by Hbbd or Hbbp males contained y2-chains as well as the y1-chains inherited from their C57BL/6 mother. The locus controlling structure of the y-chain of mouse embryonic hemoglobins is thus extremely closely linked to the locus controlling structure of adult hemoglobin beta-chain, with maximum possible recombination frequency less than 0.019.
mesh_terms: D000483:Alleles; D000818:Animals; D003433:Crosses, Genetic; D004622:Embryo, Mammalian; D005260:Female; D005319:Fetal Hemoglobin; D008040:Genetic Linkage; D014644:Genetic Variation; D046911:Macromolecular Substances; D008297:Male; D051379:Mice / Q000097:blood*; D008810:Mice, Inbred C57BL / Q000097:blood; D008815:Mice, Inbred Strains / Q000097:blood; D009154:Mutation; D010641:Phenotype; D011247:Pregnancy; D011995:Recombination, Genetic; D013045:Species Specificity
chemical_list: D046911:Macromolecular Substances; D005319:Fetal Hemoglobin