title: [Studies on absorption and excretion of cyclacillin granules (vastcillin granules 'Takeda') (author's transl)].
abstract: Vastcillin granules 'Takeda', a cyclacillin (AC-PC) preparation for children were orally administered to nine children at a single dose of 10 mg/kg and its blood concentrations and urinary excretion were studied. From the results obtained, the following conclusions were obtained as to clinical dose and indications. (1) Absorption of AC-PC of Vastcillin granules is excellent . At 15 minutes after administration, 9.3 mcg/ml of AC-PC blood level was attained and its peak appeared 30 minutes after administration. The mean peak level was 17.6 mcg/ml.
mesh_terms: D000293:Adolescent; D002648:Child; D003493:Cyclacillin / Q000008:administration & dosage / Q000378:metabolism*; D004304:Dosage Forms; D005260:Female; D006801:Humans; D007408:Intestinal Absorption; D008297:Male; D010406:Penicillins / Q000378:metabolism*
chemical_list: D004304:Dosage Forms; D010406:Penicillins; D003493:Cyclacillin