Renal handling of [(14)C]mannose.
The uptake of D-[(14)C]mannose by adult rat kidney cortex slices has been examined. The process involved appeared to be saturable and oxygen dependent and to be inhibited by glucose, galactose, chi-methyl-D-glucoside, and phlorizin. Extensive metabolism of the sugar occurred. (14)CO(2) was produced to an extent comparable to that from D-glucose. Radioactive compounds accumulated in the tissue, approximately 50% of which were in the form of phosphorylated or other polar intermediates. The remaining neutral fraction consisted of mannose with a small amount of label in glucose and an unidentified compound which behaves like an alditol. Mannose concentration in the intracellular fluid was never greater than that of the medium.
D000693:Anaerobiosis; D000818:Animals; D001692:Biological Transport; D003864:Depression, Chemical; D005690:Galactose / Q000378:metabolism; D005947:Glucose / Q000378:metabolism; D066298:In Vitro Techniques; D007672:Kidney Cortex / Q000378:metabolism*; D008297:Male; D008358:Mannose / Q000378:metabolism*; D010695:Phlorhizin / Q000494:pharmacology; D051381:Rats
D010695:Phlorhizin; D005947:Glucose; D008358:Mannose; D005690:Galactose