In vitro effects of bone cement on S. aureus growth and phagocytosis and glucose metabolism of macrophage: a preliminary study.
A preliminary study of the effects of Surgical Simplex, mixed for various time periods, was performed on S. aureus growth rate, and phagocytosis and glucose metabolism of macrophage in vitro. Quantitatively, no significant effects of the mixture on S. aureus growth rate were observed. The cement mixed for less than 4 min tended to cause adverse effects on phagocytosis rate and hexose monophosphate shunt activity of macrophage. This information may not be directly applicable to in vivo, but in vitro the cement mixture in a certain situation can cause decreased phagocytosis and hexose monophosphate shunt activity of macrophage.
D000818:Animals; D001843:Bone Cements / Q000009:adverse effects; D005947:Glucose / Q000378:metabolism; D006600:Hexosephosphates / Q000378:metabolism; D008264:Macrophages / Q000187:drug effects* / Q000378:metabolism; D010428:Pentosephosphates / Q000378:metabolism; D010587:Phagocytosis / Q000187:drug effects; D011817:Rabbits; D013211:Staphylococcus aureus / Q000254:growth & development*
D001843:Bone Cements; D006600:Hexosephosphates; D010428:Pentosephosphates; D005947:Glucose