[Decrease of disaccharidase activity following application of bencyclan-hydrogenfumarate (author's transl)].
The disaccharidase activity of the small bowel mucosa of the rat is decreased by intraperitoneal application of Bencyclan-hydrogenfumarate. The doses applied were 10, 50 and 100 mg/kg body weight. The decrease rate after 100 mg/kg attained up to 50% of the control values. Furthermore, a reduction of villous height and an increase of the crypt depth has been observed in correlation with the enzyme activity decrease. Though functional and morphological alterations show a correlation, they cannot be explained by an antimetabolic-like effect because of the fact that the enzyme function recovers 72 h after application of the drug. Whilst our results do not sustain a cytostatic effect of Bencyclan-hydrogenfumarate, there is no doubt that the intraperitoneally applied drug influences the disaccharidase activity. These facts have to be considered in clinical therapy.
D000818:Animals; D000963:Antimetabolites; D001537:Bencyclane / Q000494:pharmacology*; D003508:Cycloheptanes / Q000494:pharmacology*; D004186:Disaccharidases / Q000037:antagonists & inhibitors*; D005260:Female; D007413:Intestinal Mucosa / Q000201:enzymology* / Q000473:pathology; D007421:Intestine, Small / Q000201:enzymology* / Q000473:pathology; D051381:Rats
D000963:Antimetabolites; D003508:Cycloheptanes; D001537:Bencyclane; D004186:Disaccharidases
Depression der Disaccharidaseaktivitäten unter Bencyclan-Hydrogenfumarat