Suppression of interferon production by vitamin A.
Vitamin A (retinoic acid) suppressed interferon production by L cells infected with Newcastle disease virus (NDV). This suppression was maximal when cells were treated with retinoic acid for 2 h after NDV adsorption, indicating that the inhibitory step was an early event. It was not due to inhibition of total RNA synthesis. Retinoic acid treatment caused both a delay in appearance of interferon and a reduced rate of synthesis thereafter.
D000327:Adsorption; D007372:Interferons / Q000096:biosynthesis*; D007739:L Cells; D009522:Newcastle disease virus / Q000254:growth & development; D012313:RNA / Q000096:biosynthesis; D014212:Tretinoin / Q000494:pharmacology*; D014801:Vitamin A / Q000031:analogs & derivatives*
D014801:Vitamin A; D014212:Tretinoin; D012313:RNA; D007372:Interferons