Treatment of candidal urinary tract infection with nifuratel.
Three patients with candidal urinary tract infections were successfully treated with oral nifuratel, a nitrofuran antimicrobial agent active against yeast and Trichomonas as well as urinary bacterial pathogens. The recommended dose is 400 mg thrice daily for a week. No side effects that could be attributed to the treatment were noted. Minimum ibhibitory concentration determinations for nifuratel against Candida strains of five species showed that 48 out of 59 organisms were inhibited by 50 mg/1 or less, the three strains of Candida species eliminated from our treated patients having MICs of nifuratel in the range of 10-50 mg/1.
D000284:Administration, Oral; D000368:Aged; D002175:Candida / Q000187:drug effects; D002177:Candidiasis / Q000188:drug therapy*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009545:Nifuratel / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*; D009581:Nitrofurans / Q000627:therapeutic use*; D014552:Urinary Tract Infections / Q000188:drug therapy*
D009581:Nitrofurans; D009545:Nifuratel