title: [Antiviral activity of a poly A-poly U complex administered by various routes].
abstract: Interferon-inducing and antiviral activity of a synthetic polyribonucleotide, polyaenylic and polyuridylic acid complex (poly A--poly U) was studied comparatively on a model of experimental infection of albino mice caused by Venezuela Horse Encephalomyeliti Viruos (VHEV) using oral and intraperitoneal administration of the complex. It was shown that dm-interferon induction and antiviral effect comparatively high doses of poly A--poly U (Reanal) were required (1 mg/mouse). The highest antiviral effect was observed after a two-fold administration of the drug (24 hours and immediately before infection). It was more evident after intraperitoneal administration of the inductor. The interferon titers in the animal blood serum after intraperitoneal or oral administration of poly A--poly U were almost the same 58=60+/- +/- 18.9 IU50/ml).
mesh_terms: D000284:Administration, Oral; D000818:Animals; D000998:Antiviral Agents / Q000008:administration & dosage*; D004666:Encephalitis Virus, Venezuelan Equine / Q000187:drug effects; D004685:Encephalomyelitis, Venezuelan Equine / Q000188:drug therapy; D007274:Injections, Intraperitoneal; D007369:Interferon Inducers / Q000627:therapeutic use; D007928:Lethal Dose 50; D051379:Mice; D011063:Poly A-U / Q000008:administration & dosage*; D014779:Virus Replication / Q000187:drug effects
chemical_list: D000998:Antiviral Agents; D007369:Interferon Inducers; D011063:Poly A-U
vernacular_title: Protivovirusnaia aktivnost' kompleksa poli A-poli U pri razlichnykh putiakh vvedeniia