Genetic control of the immune response to the radom linear terpolymer of L-glutamic acid, L-lysine and L-leucine (GLleu) by complementing Ir genes.
Three levels of humoral responsiveness (none, high or marginal) were noted following secondary immunization with random linear terpolymer of L-glutamic acid, L-lysine and L-leucine (GLleu). These immune responses were under dual H-2-linked Ir gene control. Gene complementation was observed in appropriate F1 offspring between two nonresponder strains and in selected intra-I region recombinants derived from crossing over between nonresponder parental haplotypes. One of the Ir-GLleu genes, beta, was localized within the I-A or I-B subregions. The other Ir-GLleu locus, termed alpha, was mapped in the I-C or S subregions. Differences in the strain distribution of immune responsiveness to GLleu and related terpolymer GLphe (which is also under complementing Ir gene control) are primarily attributable to differences among the Ir-GLleu and Ir-GLphe beta alleles. A correlation exists between the presence of the Ir-GLleu alpha(¿allele and the gene coding for specificity Ia.7.
D000483:Alleles; D000818:Animals; D000917:Antibody Formation; D000941:Antigens; D005260:Female; D005796:Genes; D005816:Genetic Complementation Test; D008040:Genetic Linkage; D005971:Glutamates / Q000276:immunology; D006649:Histocompatibility Antigens; D007930:Leucine / Q000276:immunology; D008239:Lysine / Q000276:immunology; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D011108:Polymers / Q000276:immunology*
D000941:Antigens; D005971:Glutamates; D006649:Histocompatibility Antigens; D011108:Polymers; D007930:Leucine; D008239:Lysine