[Effect of several tropane derivatives on noradrenaline absorption by hypothalamic synaptic vesicles].
The influence of some tropan derivatives on the absorption of exogenous norepinephrine was studied in experiments on the isolated synaptic vesicles of the hypothalamus. LK II (beta-morpholinopropionic acid tropine ester dihydrochloride) at the concentration of 1. -5M decreased (like cocaine) the passive consumption of norephinephrine. The dependence of this effect on the transmitter concentration in the incubation medium was demonstrated.
D000818:Animals; D003864:Depression, Chemical; D007031:Hypothalamus / Q000187:drug effects / Q000378:metabolism*; D009638:Norepinephrine / Q000378:metabolism*; D051381:Rats; D013572:Synaptic Vesicles / Q000378:metabolism*; D014326:Tropanes / Q000494:pharmacology*
D014326:Tropanes; D009638:Norepinephrine
Vliianie nekotorykh proizvodnykh tropana na pogloschchenie noradrenalina sinapticheskimi puzyr'kami gipotalamusa