Carcinogenicity of Benzo(a)pyrene and dusts in the hamster lung (instilled intratracheally with titanium oxide, aluminum oxide, carbon and ferric oxide).
The possible carcinogenic or fibrogenic effects of intratracheal instillation of a polycyclic hydrocarbon, benzo(a) pyrene (B(a)P), alone or in combination with several dusts - titanium dioxide (TiO2), aluminum oxide (Al2O3), carbon (C), and ferric oxide (Fe3O3) - were investigated in hamsters. When administered alone, the dusts induced interstitial cell proliferation, bronchial epithelial alterations and a few granulomatous changes in the pulmonary system, but no tumors. B(a)P alone induced only two tracheal papillomas. However, combined treatment with B(a)P and the dusts caused a number of tumors, dependent upon the dust used. B(a)P plus TiO2 in a small particle size (below 0.5mu) induced papillomas, squamous cell carcinomas and a few adenomas and adenocarcinomas of the larynx, trachea and lungs. These were morpholoigcally similar to neoplasms found after B(a)P and Fe2O3 treatment. B(a)P, combined with C or Al2O3, induced mainly laryngeal and tracheal papillomas. B(a)P- and C-treated hamsters also showed a few lung adenocarcinomas.
D000230:Adenocarcinoma / Q000139:chemically induced; D000397:Air Pollution; D000535:Aluminum; D000818:Animals; D001580:Benzopyrenes; D001980:Bronchi / Q000648:ultrastructure; D002244:Carbon; D002294:Carcinoma, Squamous Cell / Q000139:chemically induced; D006224:Cricetinae; D004391:Dust; D004781:Environmental Exposure; D005290:Ferric Compounds; D007822:Laryngeal Neoplasms / Q000139:chemically induced; D008175:Lung Neoplasms / Q000139:chemically induced* / Q000648:ultrastructure; D009374:Neoplasms, Experimental / Q000139:chemically induced; D010212:Papilloma / Q000139:chemically induced; D012907:Smoking; D014025:Titanium; D014134:Tracheal Neoplasms / Q000139:chemically induced
D001580:Benzopyrenes; D004391:Dust; D005290:Ferric Compounds; D002244:Carbon; D000535:Aluminum; D014025:Titanium