The fate of the orally administered bile acid sequestrant, polidexide, in humans.
1. The metabolic fate of the insoluble bile acid sequestrant polidexide, (poly-[2-(diethylamino)ethyl] polyglycerylenedextran hydrochloride), was studied in four adult humans following the oral administration of the 14C-labelled substance. 2. The mean cumulative recovery of 14C in faeces was 95-3% (s.e.m. = 1-1) of the administered dose, while mean cumulative recovery in urine was 0-37% (s.e.m. = 0-13) of the oral dose. 3. Only background levels of radioactivity were detectable in plasma samples taken 1-3 days after administration of tracer. 4. The findings suggested that polidexide was not absorbed from the gastrointestinal in man to any significant degree.
D000328:Adult; D003637:DEAE-Dextran / Q000031:analogs & derivatives* / Q000032:analysis / Q000378:metabolism; D003911:Dextrans / Q000031:analogs & derivatives*; D005243:Feces / Q000032:analysis; D005260:Female; D006801:Humans; D008297:Male; D008895:Milk, Human / Q000378:metabolism
D003911:Dextrans; D003637:DEAE-Dextran