Myofibrillar protein pattern in experimental myotonia in rats.
Experimental myotonia was induced in rats by long-term administration of 20,25-diazacholesterol. Electrophysiological, morphological and biochemical investigations were carried out on m. soleus, m. extensor digitorum longus and m. gastrocnemius. The effect of 20,25-diazacholesterol administration on myofibrillar proteins was studied and a significant rise in the concentration of a protein presumed to be alpha-actinin was demonstrated in m. gastrocnemius. A change of the same character, not statistically significant, was observed in the m. extensor digitorum longus.
D000185:Actinin / Q000032:analysis; D000199:Actins / Q000032:analysis; D000818:Animals; D004195:Disease Models, Animal; D008297:Male; D009124:Muscle Proteins / Q000032:analysis*; D009132:Muscles / Q000473:pathology; D009210:Myofibrils / Q000032:analysis*; D009218:Myosins / Q000032:analysis; D009222:Myotonia / Q000378:metabolism* / Q000473:pathology; D051381:Rats
D000199:Actins; D009124:Muscle Proteins; D000185:Actinin; D009218:Myosins