[Enhancement of the immune response following immunization with L1210 cells preliminarily incubated with interferon].
A single intraperitioneal injection of L 1210 cells preincubated in interferon or in "false interferon" was given to mice. These mice were sacrificed on the 10th day, and cytotoxicity of the sera against the L 1210 leukemic cells vas determined in the microcytotoxic test (modification of Terasaki's method). Leukemic cells treated with interferon before the immunization caused a more pronounced immune response in comparison with the cells treated under the same conditions with "false interferon". By the results of cytotoxic reaction immune response was enhanced 2-4-fold.
D000818:Animals; D000912:Antibodies, Neoplasm / Q000096:biosynthesis*; D003601:Cytotoxicity Tests, Immunologic; D005260:Female; D007372:Interferons; D007939:Leukemia L1210 / Q000276:immunology*; D008297:Male; D051379:Mice
D000912:Antibodies, Neoplasm; D007372:Interferons
Usilenie immunogo otveta pri immunizatisii kletakami L1210, predvaritel'no inkubirovannymi v interferone