[Intestinal absorption of radiocalcium after long-term treatment with sodium fluoride in senile osteoporpsis].
Prolonged administration of sodium fluoride (NaF) in patients suffering from osteoporosis or Paget's disease leads to a positive calcium balance together with positivization of the calcium balance may mean an ins, intestinal absorption of calcium was evaluated directly with the oral rrotic patients; 6 months treatment with NaF led to a significant imprt is difficult to say how this finding is connected with the drug's actide apatite crystals; the crystals' greater stability probably leads to greater resistance of fluorated bone to the action of parathormone, thus bring on hypocalcaemia which homeostatically stimulates parathyroid hyperiirect pointer to parathyroid hyperincretion. The therapeutic effectiveness of NaF in diffuse decalcifying osteopathies is, however, limited by the drug's toxicity.
D000367:Age Factors; D000368:Aged; D001842:Bone and Bones / Q000378:metabolism; D002118:Calcium / Q000378:metabolism*; D005260:Female; D006801:Humans; D007408:Intestinal Absorption; D008875:Middle Aged; D010024:Osteoporosis / Q000188:drug therapy*; D010280:Parathyroid Glands / Q000378:metabolism; D010281:Parathyroid Hormone / Q000378:metabolism; D013997:Time Factors
D010281:Parathyroid Hormone; D002118:Calcium
L'assorbimento intestinale del radiocalcio dopo trattamento a lungo termine con fluoruro di sodio nell'osteoporosi senile