Reagin synthesis in inbred rats. II. Genetic control of reaginic antibody synthesis.
Specific reaginic (IgE) and hemagglutinating (IgG) antibodies were quantified after immunization with ovalbumin aluminum hydroxide gel in BN and ACI inbred rats, as well as their F1, F1 X BN backcross, F2, and F3, and F3 progeny. The dissimilarity of these immune responses indicated that reaginic (IgE) antibody synthesis was influenced by polygenic factors, but not sex, and was controlled by loci different from that governing hemagglutinating (IgG) antibody synthesis. In addition, tissue typing of the BN, ACI, F1, and F3 hybrids suggested that reaginic antibody synthesis was not linked to the major rat histocompatibility locus.
D000818:Animals; D000917:Antibody Formation; D005260:Female; D005796:Genes; D006650:Histocompatibility Testing; D006824:Hybridization, Genetic; D007274:Injections, Intraperitoneal; D008297:Male; D010047:Ovalbumin / Q000008:administration & dosage; D051381:Rats; D011912:Rats, Inbred ACI; D011914:Rats, Inbred BN; D011935:Reagins / Q000096:biosynthesis*
D011935:Reagins; D010047:Ovalbumin