[Experimental model of bronchial asthma (author's transl)].
Allergic asthma-like attacks were induced in guinea pigs by intraperitoneal injections of Ovalbumin and following inhalation of Ovalbumin aerosol. The animals were narcotized, tracheotomized and a small catheter was placed in mid-oesophagus. The quantities: oesophageal pressure, respiratory flow and tidal volume were measured and recorded on magnetic tape during spontaneous breathing. A technique was applied for automated computation of the parameters of respiratory mechanics using a digital computer. The parameters compliance, resistance, work of breathing and power of breathing showed typical pathological variances and characteristic response-curves in the experimental phases during and after the asthma attacks. These parameters became normal after the injection of Alupent.
D000818:Animals; D001249:Asthma / Q000503:physiopathology*; D003201:Computers; D004195:Disease Models, Animal; D006168:Guinea Pigs; D008170:Lung Compliance; D008448:Maximal Expiratory Flow Rate; D012115:Residual Volume; D014692:Ventilation-Perfusion Ratio; D014939:Work of Breathing
Tierexperimentelles Modell des Asthma bronchiale