Structure of locust adipokinetic hormone, a neurohormone that regulates lipid utilisation during flight.
Adipokinetic hormone, isolated from locust corpora cardiaca, has been identified as a blocked peptide: PCA-Leu-Asn-Phe-Thr-Pro-Asn-Trp-Gly-Thr-NH2. The detailed structure is based on mass spectrometric data, substantiated in part by dansyl-Edman and carboxypeptidase data on thermolytic fragments. This is the first peptide hormone from an insect neuroendocrine organ to be fully characterised.
D000595:Amino Acid Sequence; D000596:Amino Acids / Q000032:analysis; D000818:Animals; D005426:Flight, Animal; D006110:Grasshoppers / Q000032:analysis; D007301:Insect Hormones / Q000032:analysis* / Q000502:physiology; D007447:Invertebrate Hormones / Q000032:analysis*; D050356:Lipid Metabolism; D008297:Male; D013058:Mass Spectrometry; D013329:Structure-Activity Relationship; D014364:Tryptophan / Q000032:analysis
D000596:Amino Acids; D007301:Insect Hormones; D007447:Invertebrate Hormones; D014364:Tryptophan