Factors influencing the phagocytosis-stimulated glucose oxidation in porcine leukocytes.
The stimulation of the D-(1-14C)glucose and D-(6-14C)glucose metabolism in pig leucocytes during the phagocytosis of bacteria and inert particles was studied. The following results were obtained: 1. The magnitude of phagocytosis-stimulated glucose oxidation is directly related to the nature and number of particles added. 2. Live bacteria stimulate the glucose metabolism to a greater extent than do a similar number of heat-killed organisms. As to the extent of the stimulation the species of bacteria offered for phagocytosis is crucial. 3. After in vitro addition of a lipopolysaccharide a stimulating effect is observed, a depression has been shown after the addition of hydrocortisone.
D000818:Animals; D001419:Bacteria; D001786:Blood Glucose / Q000378:metabolism*; D005260:Female; D006854:Hydrocortisone / Q000494:pharmacology; D007700:Kinetics; D007962:Leukocytes / Q000378:metabolism / Q000502:physiology*; D008070:Lipopolysaccharides / Q000494:pharmacology; D010084:Oxidation-Reduction; D010587:Phagocytosis; D011135:Polysaccharides, Bacterial / Q000494:pharmacology; D013552:Swine
D001786:Blood Glucose; D008070:Lipopolysaccharides; D011135:Polysaccharides, Bacterial; D006854:Hydrocortisone