[Cytogenetic investigations in patients receiving an intraarticular injection of gold-198 (author's transl)].
The chromosomes of lymphocyte cultures from the peripheral blood were investigated in 10 patients (rheumatoid arthritis, ankylosing spondylitis, osteoarthrosis of the knee) before and at short-term intervals (1 day, 3 to 4 days, 14 to 18 days) after the injection of gold-198 (5 to 20 mC; usually 8 mC; average particle size 300 A) into the knee-joint. The number of structural chromosomal abberrations increased markedly in 4 of the 10 patients. On the first day after the gold injection the mean aberration rate was significantly higher than the control value (Chi2-5.18; df=1; P less than 0.05). Most of the observed aberrations were chromatid aberrations and this finding is discussed.
D000368:Aged; D001172:Arthritis, Rheumatoid / Q000188:drug therapy; D002478:Cells, Cultured; D002869:Chromosome Aberrations; D005260:Female; D006048:Gold Colloid, Radioactive / Q000009:adverse effects / Q000627:therapeutic use*; D006801:Humans; D007270:Injections, Intra-Articular; D008214:Lymphocytes; D008297:Male; D008875:Middle Aged; D010003:Osteoarthritis / Q000188:drug therapy; D013167:Spondylitis, Ankylosing / Q000188:drug therapy
D006048:Gold Colloid, Radioactive
Chromosomenuntersuchungen nach intraartikulärer Injektion von Gold-198