Studies of blood clotting system during dissociative anaesthesia with ketamine.
The effect of ketamine administered to 20 rabbits in a single dose and in fractionated doses on the blood clotting system was studied. The following blood clotting indices were determined: thrombelastography (TEG), plasma thrombin time, platelet count, euglobulin lysis time. No statistically significant differences were observed in the activity of clotting and fibrinolysis systems in the group of animals receiving a single dose of ketamine and in the group receiving fractionated doses. The obtained results suggest that ketamine as an agent used for dissociative anaesthesia can be administered safely in serious conditions associated with disturbances in the haemostasis system.
D000758:Anesthesia / Q000379:methods*; D000818:Animals; D001777:Blood Coagulation / Q000187:drug effects*; D005174:Factor XII / Q000502:physiology; D005260:Female; D005342:Fibrinolysis / Q000187:drug effects*; D007649:Ketamine / Q000494:pharmacology*; D008297:Male; D011817:Rabbits
D007649:Ketamine; D005174:Factor XII