Tobramycin and cephalothin sodium in treatment of infected patients with acute leukemia.
Tobramycin has been shown to be safe and effective when given intravenously in combination antibiotic therapy for infected patients with acute leukemia or other profound pancytopenic states. Tobramycin in combination with one or more antibiotics (usually cephalothin) produced satisfactory clinical results in 21 of 30 episodes of fever. Toxic effects were minimal and were limited to occasional mild thrombophlebitis.
D000208:Acute Disease; D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D001424:Bacterial Infections / Q000150:complications / Q000188:drug therapy*; D002512:Cephalothin / Q000627:therapeutic use*; D004359:Drug Therapy, Combination; D006801:Humans; D007710:Klebsiella Infections / Q000188:drug therapy; D007938:Leukemia / Q000150:complications*; D011552:Pseudomonas Infections / Q000188:drug therapy; D014031:Tobramycin / Q000627:therapeutic use*
D000900:Anti-Bacterial Agents; D002512:Cephalothin; D014031:Tobramycin