title: Tonic pupil: a simple screening test.
abstract: The tonic pupil has a typical appearance and characteristic reactions to both light and the near reflex. Testing with Mecholyl (methacholine) is not possible since the drug is no longer manufactured. The reactions of a group of 25 patients with tonic pupil were studied using dilute pilocarpine, and compared with the pupil responses of a separate control group. We found that concentrations of 0.2% pilocarpine produced too many false-positive reactions in the control group and that 0.05% pilocarpine produced an insufficient response. The 0.1% concentration seemed suitable for ordinary clinical examinations and is recommended for pharmacologic confirmation of the diagnosis of tonic (Adie's) pupil.
mesh_terms: D000270:Adie Syndrome / Q000175:diagnosis*; D000328:Adult; D005189:False Positive Reactions; D005260:Female; D006801:Humans; D008297:Male; D010862:Pilocarpine / Q000008:administration & dosage
chemical_list: D010862:Pilocarpine