title: Selectivity of 4-methoxyphenethylamine derivatives as inhibitors of monoamine oxidase.
abstract: It has been established that the oxidative deamination of tyramine by monoamine xodase is inhibited by (+/-)-4-methoxy-beta-hydroxyphenethylamine and its N-methylated derivatives. This particular series of compounds does not inhibit the action of monoamine oxidase when tryptamine is used as the substrate. In contrast, 4-methoxyphenethylamine and its N-methylated homologs inhibit the monoamine oxidase-catalyzed deamination of both tyramine and tryptamine.
mesh_terms: D000818:Animals; D001921:Brain / Q000648:ultrastructure; D005260:Female; D066298:In Vitro Techniques; D008365:Manometry; D008722:Methods; D008928:Mitochondria / Q000201:enzymology; D008996:Monoamine Oxidase Inhibitors; D010627:Phenethylamines / Q000138:chemical synthesis / Q000494:pharmacology*; D051381:Rats; D014363:Tryptamines / Q000378:metabolism; D014439:Tyramine / Q000378:metabolism
chemical_list: D008996:Monoamine Oxidase Inhibitors; D010627:Phenethylamines; D014363:Tryptamines; D014439:Tyramine