An analysis of the effect of random and ageing mechanisms on the survival of platelets.
Human platelets survival curves make it possible to estimate two factors which could be held responsible for the disappearance of cells: a) random destruction b) ageing of the platelets. This study was devoted to non-thrombocytopenic patients with chronic vascular disease. In 40% of the cases, the platelet destruction was found to be due to normal ageing of the cells combined with a random destruction process. The estimation of both of these parameters is of interest for the clinical survey of these patients. The statistical analysis of the remaining 60% of the cases presented here has demonstrated a pure linear disappearance of the labelled platelets. This obsveration favours ageing as the cause of the destruction of the platelets.
D000368:Aged; D001792:Blood Platelets; D002470:Cell Survival; D006801:Humans; D008433:Mathematics