The significance of embryonic reexpression in cancer.
Irradiated syngeneic mouse testicular cells and the first-trimester human fetal tissue cells protect mice partially against tumors induced by methylcholanthrene or against a syngeneic transplantable mouse tumor, Meth A, respectively. For future research it is suggested that experiments should have a therapeutic rather than a prophylactic design and that the induction of tolerance to fetal antigens could be a highly informative procedure.
D000818:Animals; D000941:Antigens; D000951:Antigens, Neoplasm; D003429:Cross Reactions; D004622:Embryo, Mammalian / Q000276:immunology*; D006649:Histocompatibility Antigens; D006801:Humans; D007167:Immunotherapy; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D009369:Neoplasms / Q000276:immunology* / Q000628:therapy; D013737:Testis / Q000276:immunology
D000941:Antigens; D000951:Antigens, Neoplasm; D006649:Histocompatibility Antigens