title: Induction of uterine ornithine decarboxylase (ODC) by antiestrogens. Inhibition of estradiol-mediated induction of ODC: a possible mechanism of action of antiestrogens.
abstract: The ability of antiestrogens (tamoxifen and nafoxidine) to affect uterine ornithine decarboxylase (ODC) in the ovariectomized rat was determined. Tamoxifen citrate (1 mg or 10 mg/kg) and nafoxidine (0.5 mg/kg) markedly elevated ODC levels. Tamoxifen (1 mg/kg) given for 4 days totally inhibited the E2 (0.5 mug/kg)-mediated induction of ODC. Similarly nafoxidine (0.5 mug/kg) given once a day for 2 days inhibited the E2-mediated induction of ODC. The relation of the inhibition of ODC induction by antiestrogens to their mechanism of action as antiestrogens is discussed.
mesh_terms: D000818:Animals; D002262:Carboxy-Lyases / Q000096:biosynthesis*; D002369:Castration; D004790:Enzyme Induction; D004958:Estradiol / Q000494:pharmacology; D005260:Female; D009256:Nafoxidine / Q000494:pharmacology*; D009955:Ornithine Decarboxylase / Q000096:biosynthesis*; D011759:Pyrrolidines / Q000494:pharmacology*; D051381:Rats; D013267:Stilbenes / Q000494:pharmacology*; D013629:Tamoxifen / Q000494:pharmacology*; D013997:Time Factors; D014599:Uterus / Q000187:drug effects / Q000201:enzymology*
chemical_list: D011759:Pyrrolidines; D013267:Stilbenes; D013629:Tamoxifen; D009256:Nafoxidine; D004958:Estradiol; D002262:Carboxy-Lyases; D009955:Ornithine Decarboxylase