[Changes of triglycerid-fatty acids in healthy volunteers during acute ethanol ingestion with and without blocking peripheral lipolysis (author's transl)].
This investigation decided to answer the question of the origin of fatty acids for the increased synthesis of triglycerides in acute ethanol-induced hyperlipoproteinemia. Healthy persons ingested 0.5 g of ethanol/kg body weight initially and 0,15 g of ethanol/kg and hour for 12 hours. The fatty acids of plasma triglycerides were determined before and after ingestion of ethanol in persons fasting and nourished isocaloricaly, with and without blocking peripheral lipolysis by nicotinic acid and with addition of glucose. The fasting persons triglycerides fatty acids increased to 165.7 % of the initial value after 12 hours of ethanol ingestion, with a preferential increase in palmitic-, oleic- and stearic acid. When lipolysis in adipose tissue was blocked by 0.5 g of nicotinic adic/hour the triglyceride-fatty acids reached only 116.2% after 12 hours, with a decrease in oleic acid, which is present in adipose tissue to a higher degree than in plasma triglycerides. When nourished isocaloricaly, the enhancement of plasma triglyceride-fatty acids could not be suppressed by nicotinic acid. The changes in concentration and pattern of triglyceride-fatty acids announce that the fatty acids used for increased synthesis of triglycerides in fasting persons come from adipose tissue preferentially. In contrast ethanol-ingested hyperlipoproteinemia during ingestion of a food which cannot be suppressed by nicotinic acid, seems to orginate from fatty acids of the food and for de novo synthesis of fatty acids in the liver.
D000273:Adipose Tissue / Q000378:metabolism; D000293:Adolescent; D000328:Adult; D004041:Dietary Fats; D000431:Ethanol / Q000494:pharmacology*; D005215:Fasting; D005227:Fatty Acids / Q000097:blood*; D005260:Female; D005947:Glucose / Q000494:pharmacology; D006801:Humans; D008099:Liver / Q000378:metabolism; D008297:Male; D009539:Nicotinic Acids / Q000494:pharmacology; D014280:Triglycerides / Q000096:biosynthesis / Q000097:blood*
D004041:Dietary Fats; D005227:Fatty Acids; D009539:Nicotinic Acids; D014280:Triglycerides; D000431:Ethanol; D005947:Glucose
Verhalten der Triglycerid-Fettsäuren bei fastenden und isokalorischen ernährten Versuchspersonen unter akuter Athanolbelastung. Einfluss der Lipolysehemmung durch Nikotinsäure und Glucose