A new broad spectrum aminoglycoside antibiotic, G-52, produced by Micromonospora zionensis.
G-52 is a new broad spectrum aminoglycoside produced by a species of the genus Micromonospora, Micromonospora zionensis. It has been differentiated from other known related antibiotics by a variety of chemical and biological methods. Its in vitro and in vivo spectrum of activity appears to be quite similar to that of verdamicin and gentamicin but is differentiated from them by its increased activity against 6'-N-acetylating strains.
D000818:Animals; D000900:Anti-Bacterial Agents / Q000031:analogs & derivatives*; D001424:Bacterial Infections / Q000188:drug therapy; D001681:Biological Assay; D006868:Hydrolysis; D007928:Lethal Dose 50; D008297:Male; D051379:Mice; D008847:Micromonospora / Q000254:growth & development / Q000378:metabolism*; D012853:Sisomicin / Q000031:analogs & derivatives* / Q000096:biosynthesis / Q000302:isolation & purification / Q000494:pharmacology; D013210:Staphylococcus / Q000187:drug effects
D000900:Anti-Bacterial Agents; D012853:Sisomicin