Outcome of pregnancy after clomiphene therapy.
Of 159 pregnancies conceived after clomiphene therapy, 141 ended in childbirth, including seven sets of twins. There was a probable increase in the number of infants born with major malformations. These were exclusively to women who had not previously borne a normal infant. The incidence of malformed infants compares well with that published after gonadotropin therapy. The possibly higher incidence of malformations seen after drug-induced ovulation would therefore seem to be due to the underlying subfertility state and thus not a direct drug effect.
D000014:Abnormalities, Drug-Induced; D000858:Anovulation / Q000188:drug therapy*; D002996:Clomiphene / Q000009:adverse effects* / Q000627:therapeutic use; D005260:Female; D006801:Humans; D011247:Pregnancy; D011248:Pregnancy Complications / Q000139:chemically induced; D011272:Pregnancy, Multiple; D013723:Teratogens; D014427:Twins
D013723:Teratogens; D002996:Clomiphene