Fluctuation and relaxation analysis of monazomycin-induced conductance in black lipid membranes.
Fluctuation and relaxation analyses were performed on monazomycin-induced conductance of lipid bilayer membranes. With both methods a slow (sec) and a fast (msec) current component are apparent; however, the amplitude of the slow, voltage-dependent process is greater than that of the fast component in the step relaxation experiment and less in the fluctuation experiment. The fluctuation analysis showed principally a rapid voltage-dependent process which appears to be related to the multistate character of the conducting channel. The experimental results are interpreted in terms of a simplified kinetic model which is used to calculate relaxation and noise amplitudes.
D000408:Alamethicin; D000900:Anti-Bacterial Agents; D001665:Binding Sites; D002784:Cholesterol; D004553:Electric Conductivity; D007700:Kinetics; D008433:Mathematics; D008567:Membranes, Artificial; D008954:Models, Biological; D010713:Phosphatidylcholines
D000900:Anti-Bacterial Agents; D008567:Membranes, Artificial; D010713:Phosphatidylcholines; D000408:Alamethicin; D002784:Cholesterol