Comparison of observed and predicted first-pass metabolism of imipramine in humans.
The first-pass metabolism of imipramine was calculated based on the dose, hepatic blood flow, and total area under the plasma-time curve after oral administration of 0.71 +/- 0.03 mg/kg of imipramine to four individuals suffering from mild depression. The predicted values of first-pass metabolism ranged from 37 to 68%, consistent with experimentally derived estimates.
D000328:Adult; D001682:Biological Availability; D005260:Female; D006801:Humans; D007099:Imipramine / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D013997:Time Factors
D007099:Imipramine