[Effect of glucocorticoids on the pharmacokinetics of kanamycin in rabbits].
The effect of hydrocortisone on kanamycin pharmacokinetics in rabbits treated with the drugs administered intramuscularly in two different syringes simultaneously and in one syringe was studied. When the drugs were administered in two different syringes, there were no changes in the antibiotic pharmacokinetics as compared to the control group, while administration of the drugs in one syringe resulted in decreased excretion of the antibiotic with urine and a significant increase of its levels in the blood, liquor and tissues.
D000818:Animals; D001702:Biopharmaceutics; D004338:Drug Combinations; D004347:Drug Interactions; D006854:Hydrocortisone / Q000494:pharmacology*; D007273:Injections, Intramuscular; D007612:Kanamycin / Q000032:analysis / Q000494:pharmacology*; D007700:Kinetics; D011817:Rabbits; D013997:Time Factors
D004338:Drug Combinations; D007612:Kanamycin; D006854:Hydrocortisone
K voprosu o vliianii gliukokortikoidov na farmakokinetiku kanamitsina u krolikov