title: Effect of varying vitamin B6 intake of early-weaned piglets on urinary xanthurenic and kynurenic acid excretion, serum transaminase activity and urea concentration.
abstract: In a bipartite rearing experiment (day 1-24 and 24-45) 72 early-weaned piglets were used to study the effect of varying dietary vitamin B6 contents on renal excretion of xanthurenic and kynurenic acid after a tryptophan load, on urea concentration and activities of two transaminases in serum at the end of each period. The animals, divided into 6 groups, were fed ad libitum a prestarter and a starter in period I and II, respectively, each containing 0.5, 1.2, 2.0, 2.8, 3.5 or 6.6 mg vitamin B6 per kg dry matter. The urinary xanthurenic acid excretion was elevated especially at the vitamin B6 supply of 0.5 ppm and rose severalfold with increasing depletion time (period II). In both periods, the smallest amount was excreted by piglets supplemented with 2.8 ppm. In comparison to groups B (1.2 ppm) and C (2.0 ppm), their average excretion rate was reduced by 29% and 15%, respectively, in period I and by 50% and 22%, respectively, in period II. Analogously to xanthurenic acid, the smallest amount of kynurenic acid was excreted by group D (2.8 ppm). Starting from the lowest vitamin B6 supply, the activity of SGPT showed an almost linear increase in both experimental periods. In contrast, SGOT already reached an upper activity level with the dietary vitamin B6 content of 3.5 and 2.8 ppm at the end of period I and II, respectively. The concentration of serum urea was influenced only by the lowest vitamin B6 supply of 0.5 ppm.
mesh_terms: D000410:Alanine Transaminase / Q000097:blood*; D000818:Animals; D001219:Aspartate Aminotransferases / Q000097:blood*; D004032:Diet; D005260:Female; D007736:Kynurenic Acid / Q000652:urine*; D008297:Male; D011736:Pyridoxine / Q000008:administration & dosage / Q000494:pharmacology*; D013552:Swine; D014508:Urea / Q000097:blood*; D014886:Weaning; D014977:Xanthurenates / Q000652:urine*
chemical_list: D014977:Xanthurenates; D014508:Urea; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase; D007736:Kynurenic Acid; D011736:Pyridoxine