Potentiation of the effects of topical epinephrine on the pupil and intraocular pressure in the sympathetically denervated rabbit eye by a catechol-O-methyl transferase inhibitor.
Dose-response curves of increase in pupil size and decrease in intraocular pressure with topical epinephrine have been determined in the sympathetically denervated rabbit eye. Topical pretreatment with the catechol-O-methyl transferase inhibitor U-0521 potentiated the effects of epinephrine on both the pupil and pressure. These observations suggest a possible role for catechol-O-methyl transferase in the aqueous humor dynamics of the supersensitive eye. The possible use of the denervated rabbit eye as an experimental model for the glaucomatous eye in evaluating the ocular effects of adrenergic agents is discussed.
D000287:Administration, Topical; D000818:Animals; D065098:Catechol O-Methyltransferase Inhibitors; D003714:Denervation; D004305:Dose-Response Relationship, Drug; D004357:Drug Synergism; D004837:Epinephrine / Q000008:administration & dosage / Q000494:pharmacology*; D005123:Eye / Q000294:innervation; D007429:Intraocular Pressure / Q000187:drug effects*; D011292:Premedication; D011427:Propiophenones / Q000008:administration & dosage / Q000494:pharmacology; D011680:Pupil / Q000187:drug effects*; D011817:Rabbits; D013562:Sympathectomy
D065098:Catechol O-Methyltransferase Inhibitors; D011427:Propiophenones; D004837:Epinephrine