Defective PGE reactivity in leucocytes of multiple sclerosis patients.
Leucocyte migration inhibition in vitro, in response to antigen or mitogen, is suppressed by PGE2 (0.01-1.0 mug/ml). The susceptibility of leucocytes to such inhibition by PGE2 has been compared using cell preparations obtained from normal individuals, multiple sclerosis patients and from patients with other neurological diseases. The results indicate defective reactivity of leucocytes from multiple sclerosis patients.
D000328:Adult; D000942:Antigens, Bacterial; D002464:Cell Migration Inhibition; D004305:Dose-Response Relationship, Drug; D005260:Female; D006801:Humans; D037102:Lectins / Q000494:pharmacology; D007962:Leukocytes / Q000276:immunology*; D008297:Male; D008875:Middle Aged; D009103:Multiple Sclerosis / Q000276:immunology*; D011458:Prostaglandins E / Q000008:administration & dosage / Q000494:pharmacology*
D000942:Antigens, Bacterial; D037102:Lectins; D011458:Prostaglandins E