Clinical and biochemical parameters during neuroleptic treatment. III. Primitive reflexes during neuroleptic treatment.
Palmomental reflex, glabellar reflex and oral responses were studied in the course of a treatment with Haloperidol in 14 psychotic patients with a chronic organic brain damage. An increase of the three responses was found; maximum intensity and frequency of the primitive reflexes were reached during the first 5 days of treatment. There was no correlation found between the intensity of primitive reflexes and changes of psychopathological symptoms, of extrapyramidal scores and of homovanillic acid (=HVA) and 5-hydroxyindoleacetic acid (5=5-HIAA) concentration in cerebrospinal fluid (=CSF). The presence of primitive responses is interpreted as a "decompensation phenomenon" induced by neuroleptics, probably in relation to an effect on the central nervous system (=CNS) dopamine receptors. It is suggested that the appearance of several definite, primitive reflexes during neuroleptic therapy may have some diagnostic and prognostic significance.
D000328:Adult; D000368:Aged; D001925:Brain Damage, Chronic / Q000503:physiopathology; D002680:Chin; D005260:Female; D005546:Forehead; D006220:Haloperidol / Q000494:pharmacology*; D006225:Hand; D006801:Humans; D008046:Lip; D008297:Male; D008875:Middle Aged; D012018:Reflex / Q000187:drug effects*
D006220:Haloperidol