An improved model of experimentally induced ocular hypertension in the rabbit.
A model of experimentally induced ocular hypertension for the evaluation of antiglaucoma drugs in the unanesthetized rabbit is described. It is based on the intravenous infusion of suitable amounts of 5 per cent glucose solution, and advantageously substitutes the oral water load. The method is sensitive to drugs acting both on the outflow facility (2 per cent pilocarpine) and an aqueous humor formation (10 per cent guanethidine).
D000818:Animals; D004305:Dose-Response Relationship, Drug; D005260:Female; D005901:Glaucoma / Q000139:chemically induced* / Q000188:drug therapy; D005947:Glucose / Q000008:administration & dosage*; D005950:Glucose Solution, Hypertonic / Q000008:administration & dosage* / Q000009:adverse effects; D006145:Guanethidine / Q000627:therapeutic use; D007263:Infusions, Parenteral; D007429:Intraocular Pressure / Q000187:drug effects*; D008297:Male; D008954:Models, Biological; D010862:Pilocarpine / Q000627:therapeutic use; D011817:Rabbits
D005950:Glucose Solution, Hypertonic; D010862:Pilocarpine; D005947:Glucose; D006145:Guanethidine