The suppressive effect of the interferon on the ability of mouse spleen cells synthesizing IgE to sensitize rat skin for heterologous adoptive cutaneous anaphylaxis.
Mouse spleen cells which are synthesizing IgE can sensitize rat skin for HACA. When such cells are treated with mouse interferon, their ability to sensitize rat skin is reduced or completely inhibited. Two hundred PRD50 units of interferon reduced HACA reactions by more than 50%; 600 units gave complete inhibition. Interferon may act by inhibiting IgE synthesis and/or release.
D000818:Animals; D004306:Dose-Response Relationship, Immunologic; D007073:Immunoglobulin E / Q000096:biosynthesis*; D007166:Immunosuppressive Agents; D007372:Interferons / Q000494:pharmacology*; D051379:Mice; D010047:Ovalbumin / Q000494:pharmacology; D010323:Passive Cutaneous Anaphylaxis; D011817:Rabbits; D051381:Rats; D013045:Species Specificity; D013154:Spleen / Q000276:immunology*; D013997:Time Factors
D007166:Immunosuppressive Agents; D007073:Immunoglobulin E; D010047:Ovalbumin; D007372:Interferons