[Investigations of the mode action of buformin using a 3H-labelled glucose in people with a healthy metabolism (author's transl)].
In a total of 13 volunteers the changes in carbohydrate metabolism was investigated after administration of prednisolone, of buformin, and of a combination of prednisolone and buformin using 3H-labelled glucose. Under steady-state-conditions the glucose-turnover was estimated. Although, the changes of glucose assimilation of labelled and unlabelled glucose was observed to see the magnitude of glucose utilisation and of gluconeogenesis. It was concluded that biguanides enhance the glucose utilisation. Depending on the glucose level at the same time the gluconeogenesis is stimulated or inhibited.
D001645:Biguanides / Q000494:pharmacology*; D001786:Blood Glucose / Q000378:metabolism; D002026:Buformin / Q000494:pharmacology*; D004347:Drug Interactions; D005943:Gluconeogenesis / Q000187:drug effects*; D005947:Glucose / Q000037:antagonists & inhibitors / Q000378:metabolism*; D005951:Glucose Tolerance Test; D006207:Half-Life; D006801:Humans; D011239:Prednisolone / Q000494:pharmacology; D014316:Tritium
D001645:Biguanides; D001786:Blood Glucose; D014316:Tritium; D011239:Prednisolone; D005947:Glucose; D002026:Buformin
Untersuchungen zum Wirkungsmechanismus von Buformin mit Hilfe tritiierter Glucose bei stoffwechselgesunden Personen