The oxidative metabolism of alpha-chlorohydrin and the chemical induction of spermatocoeles.
alpha-Chlorohydrin (I) is oxidatively metabolized to beta-chlorolactic acid (III) and oxalic acid (IV). Deposition of calcium oxalate within the renal tubules is responsible for the toxic effects of alpha-chlorohydrin and a similar action on the epididymis or epididymal blood vessels could initiate the formation of spermatocoeles from this and other male antifertility agents.
D000818:Animals; D001002:Anuria / Q000139:chemically induced; D004231:Diuresis / Q000187:drug effects; D007676:Kidney Failure, Chronic / Q000139:chemically induced; D007684:Kidney Tubules / Q000032:analysis; D007773:Lactates / Q000378:metabolism / Q000494:pharmacology; D008297:Male; D010070:Oxalates / Q000032:analysis / Q000378:metabolism / Q000494:pharmacology; D051381:Rats; D013088:Spermatocele / Q000139:chemically induced*
D007773:Lactates; D010070:Oxalates