Blood pressure fall by angiotensin II antagonist in patients with Bartter's syndrome.
Intravenous infusion of 600 ng/kg/min of 1-sarcosine, 8-isoleucine-angiotensin II, an angiotensin II antagonist, caused a marked blood pressure fall and a decrease in plasma aldosterone in 3 patients with Bartter's syndrome. These results indicate that proximal cause of Bartter's syndrome is an arteriolar hyporesponsiveness to angiotensin II and that this angiotensin II analogue has an antagonist activity on peripheral arterioles as well as adrenal cortex.
D000328:Adult; D000450:Aldosterone / Q000097:blood; D000804:Angiotensin II / Q000031:analogs & derivatives* / Q000037:antagonists & inhibitors / Q000627:therapeutic use; D001477:Bartter Syndrome / Q000097:blood / Q000188:drug therapy*; D001794:Blood Pressure; D002648:Child; D006801:Humans; D006854:Hydrocortisone / Q000097:blood; D006929:Hyperaldosteronism / Q000188:drug therapy*; D008297:Male; D010455:Peptides / Q000097:blood
D010455:Peptides; D000804:Angiotensin II; D000450:Aldosterone; D006854:Hydrocortisone