Anticholinergic exacerbation of phenothiazine-induced extrapyramidal syndrome.
The authors used tremography to record the bilateral digital tremor of a patient showing extrapyramidal system effects in response to withdrawal from phenothiazines. They found that changes in the amplitude of tremor correlated with clinical ratings of extrapyramidal disturbance. Changes in the amplitude and in the spectrum of tremor were similar to the bipolar paradoxical changes seen during intoxication with an anticholinergic psychotogen.
D000328:Adult; D001480:Basal Ganglia Diseases / Q000139:chemically induced* / Q000175:diagnosis; D002746:Chlorpromazine / Q000009:adverse effects*; D006801:Humans; D013375:Substance Withdrawal Syndrome / Q000175:diagnosis*; D014268:Trifluoperazine / Q000009:adverse effects*; D014282:Trihexyphenidyl / Q000009:adverse effects*
D014268:Trifluoperazine; D014282:Trihexyphenidyl; D002746:Chlorpromazine