[In vitro and in vivo experiments on the immunosuppressive properties of cytostatic substances (author's transl)].
Various cystostatic substances are tested with the lymphocyte transformation test and compared with the effect on the experimental contact eczema of the guinea pig. Only methotrexate influences the eczematous reaction. The in vitro and in vivo effects are not identical.
D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology* / Q000627:therapeutic use; D003520:Cyclophosphamide / Q000494:pharmacology; D003877:Dermatitis, Contact / Q000139:chemically induced / Q000188:drug therapy; D005472:Fluorouracil / Q000494:pharmacology; D006168:Guinea Pigs; D007165:Immunosuppression Therapy; D066298:In Vitro Techniques; D008213:Lymphocyte Activation / Q000187:drug effects*; D008727:Methotrexate / Q000494:pharmacology; D014750:Vincristine / Q000494:pharmacology
D000970:Antineoplastic Agents; D014750:Vincristine; D003520:Cyclophosphamide; D005472:Fluorouracil; D008727:Methotrexate
In-vitro und In-vivo-Untersuchungen zur immunsuppressiven Wirkung zytostatischer Substanzen