Biotin status and lipid metabolism in adult obese hypercholesterolemic inbred rats.
A statistically significant inverse association was generally found between plasma total lipid, cholesterol, or phospholipid and biotin status of 300-day-old male inbred BHE (IN-BHE) rats. Plasma, liver, and carcass lipid of both sexes generally had a significant direct association with liver lactate dehydrogenase activity; an inverse association in males resulted with improved biotin status. Elevated plasma lactate indicative of anaerobic glycolysis was found. It is proposed that an increased reductive environment - a consequence of accumulated NADH - could account for enhanced triglyceride synthesis and that this effect could explain the obesity in the IN-BHE rats. After the injection of 300 mug of biotin, plasma levels of lactate and pyruvate fell in male rats, indicating a stimulatory effect of biotin upon the oxidative pathways in these animals.
D000818:Animals; D001710:Biotin / Q000097:blood / Q000378:metabolism* / Q000494:pharmacology; D002784:Cholesterol / Q000097:blood; D002952:Citric Acid Cycle; D005260:Female; D006937:Hypercholesterolemia / Q000097:blood / Q000378:metabolism*; D007770:L-Lactate Dehydrogenase / Q000378:metabolism; D007773:Lactates / Q000097:blood; D050356:Lipid Metabolism; D008055:Lipids / Q000097:blood; D008099:Liver / Q000201:enzymology; D008297:Male; D009765:Obesity / Q000097:blood / Q000378:metabolism*; D011773:Pyruvates / Q000097:blood; D051381:Rats; D011919:Rats, Inbred Strains
D007773:Lactates; D008055:Lipids; D011773:Pyruvates; D001710:Biotin; D002784:Cholesterol; D007770:L-Lactate Dehydrogenase