Pertussis vaccine pleurisy: a model of delayed hypersensitivity.
Male Wistar rats have been sensitized to Bordetella pertussis using a mixture of Freund's incomplete adjuvant and pertussis organisms. Intrapleural challenge 12 days later with pertussis produced a marked delayed inflammatory response, maximal at 48 hours and dominated by influx of mononuclear cells. Dosing with D-penicillamine (25 mg/kg) and levamisole (5 mg/kg) at the time of challenge produced a significant enhancement of the reaction. A long period of dosing with either drug, or treatment with indomethacin (3 mg/kg), suppressed the response. The relevance of this to the testing and mode of action of antirheumatic drugs is discussed.
D000818:Animals; D004195:Disease Models, Animal; D004334:Drug Administration Schedule; D005620:Freund's Adjuvant / Q000494:pharmacology; D006968:Hypersensitivity, Delayed / Q000139:chemically induced* / Q000276:immunology; D007213:Indomethacin / Q000276:immunology / Q000494:pharmacology; D007978:Levamisole / Q000276:immunology / Q000494:pharmacology; D008297:Male; D010396:Penicillamine / Q000276:immunology / Q000494:pharmacology; D010567:Pertussis Vaccine / Q000494:pharmacology*; D010998:Pleurisy / Q000209:etiology*; D051381:Rats; D011919:Rats, Inbred Strains; D013997:Time Factors
D010567:Pertussis Vaccine; D007978:Levamisole; D005620:Freund's Adjuvant; D010396:Penicillamine; D007213:Indomethacin