Synthesis and characterization of alpha-phenyl-gamma-butyrolactone, a metabolite of glutethimide, phenobarbital and primidone, in human urine.
A novel metabolite, alpha-phenyl-gamma-butyfolactone has been isolated in urine samples of patients severely intoxicated by either glutethimide, phenobarbital, or primidone. This lactone was prepared synthetically and its spectral data and chromatographic properties were compared to those data obtained from the urine samples of drug overdosed victims. The results of these comparisons confirm the presence of this lactone in human urine following the ingestion of large amounts of the parent drug.
D005984:Glutethimide / Q000378:metabolism* / Q000506:poisoning; D006801:Humans; D010634:Phenobarbital / Q000378:metabolism* / Q000506:poisoning; D011324:Primidone / Q000378:metabolism* / Q000506:poisoning
D011324:Primidone; D005984:Glutethimide; D010634:Phenobarbital