Hapten-specific lymphocyte transformation in humans sensitized with NDMA or DNCB.
The primary immune response to a contact sensitizing dose of para-N-dimethylnitrosaniline (NDMA) and dinitrochlorobenzene (DNCB) was obtained in humans and measured in vitro by increased thymidine incorporation into sensitized lymphocytes. No cross-reaction was found between these two haptens, and it is thus possible on two separate occasions to quantify and follow the primary cellular immune response in man.
D000814:Aniline Compounds / Q000276:immunology*; D000917:Antibody Formation; D002478:Cells, Cultured; D003429:Cross Reactions; D004137:Dinitrochlorobenzene / Q000276:immunology*; D006241:Haptens; D006801:Humans; D007111:Immunity, Cellular; D007114:Immunization; D008213:Lymphocyte Activation; D009578:Nitrobenzenes / Q000276:immunology*; D009603:Nitroso Compounds
D000814:Aniline Compounds; D004137:Dinitrochlorobenzene; D006241:Haptens; D009578:Nitrobenzenes; D009603:Nitroso Compounds