Toxicity and plant growth regulator effects of cytochalasin H isolated from Phomopsis sp.
A biologically active metabolite was found in crude extracts of an unidentified species of Phomopsis isolated from weevil-damaged pecans. Purified metabolite was toxic to day-old cockerels, with an LD50 of 12.5 mg/kg, and was markedly inhibitory to growth the floral development of tobacco plants at concentrations of 10(-2) to 10(-4) M. IR and 1H-nmr spectra indicated an alkylpheny moiety with a single nitrogen atom present as a secondary amide; and acetate ester, OH, CH3, and a trans-double bond function. Elemental and high-resolution mass-spectral analysis indicated a formula of C30H39NO5 and a molecular weight of 493.2886. The metabolite was identified as cytochalasin H.
D000818:Animals; D002645:Chickens; D003572:Cytochalasins / Q000096:biosynthesis / Q000494:pharmacology* / Q000633:toxicity; D008297:Male; D003904:Mitosporic Fungi / Q000378:metabolism; D063245:Plant Development
D003572:Cytochalasins