title: Monoamine acid metabolites in ventricular CSF of patients with brain tumours.
abstract: Homovanillic acid (HVA) and 5-hydroxyindolacetic acid (5-HIAA) in ventricular CSF were determined in 19 patients (12 female 7 male) with brain tumours. No relationship was found between ventricular fluid pressure (VFP) and levels of HVA and 5-HIAA. A relationship was observed between ventricular CSF, HVA concentrations and tumour induced alterations in CSF dynamics. HVA concentrations were very high in patients whose tumours involved the third ventricle, the aqueduct, or the fourth ventricle, producing marked alterations in CSF flow. HVA concentrations significantly lower than in controls were observed in cases where tumours involved the lateral ventricles. Concentrations of acid metabolites in patients with little or no alteration in CSF dynamics corresponded with those in patients with other neurosurgical disorders.
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D001932:Brain Neoplasms / Q000134:cerebrospinal fluid* / Q000150:complications; D002551:Cerebral Ventricle Neoplasms / Q000134:cerebrospinal fluid; D002552:Cerebral Ventricles; D002648:Child; D002675:Child, Preschool; D005260:Female; D006719:Homovanillic Acid / Q000134:cerebrospinal fluid*; D006801:Humans; D006849:Hydrocephalus / Q000134:cerebrospinal fluid / Q000209:etiology; D006897:Hydroxyindoleacetic Acid / Q000134:cerebrospinal fluid*; D007427:Intracranial Pressure; D008297:Male; D008875:Middle Aged; D010648:Phenylacetates / Q000134:cerebrospinal fluid*
chemical_list: D010648:Phenylacetates; D006897:Hydroxyindoleacetic Acid; D006719:Homovanillic Acid