Effects of human and experimental cancer on the conversion of 14C tripalmitin to 14CO2.
14C Tripalmitin was administered intraperitoneally to control mice and to mice bearing subcutaneous Krebs-2 carcinoma. The rate of excretion of 14CO2 was studied. The presence of a tumor induced a greater than 80% suppression of the formation of 14CO2 within 24 hours from the implantation of the tumor, thus allowing unambiguous identification of the tumor-bearing mice. When cancer patients were studied, along with normal volunteers and patients with non-neoplastic diseases, 14CO2 excretion data could be used to identify the cancer patients with an overall accuracy of 84%.
D000818:Animals; D002245:Carbon Dioxide / Q000096:biosynthesis; D002287:Carcinoma, Krebs 2 / Q000378:metabolism*; D005260:Female; D006801:Humans; D008297:Male; D051379:Mice; D009369:Neoplasms / Q000378:metabolism*; D010101:Oxygen Consumption; D010169:Palmitic Acids / Q000378:metabolism*
D010169:Palmitic Acids; D002245:Carbon Dioxide