Use of dantrolene sodium in external sphincter spasm.
In various neurologic and non-neurologic diseases inappropriate hypertonicity of the external sphincter during micturition may cause outlet obstruction. Heretofore therapy for these disorders has been surgical: pudenal neurectomy or external sphincterotomy. These procedures are not without complication (incontinence, impotence, hemorrhage). A medical approach to this disorder is therefore warranted. In a selected group of patients with external sphincter spasm diagnosed by concitant sphincter electromyography, cystometrography, and voiding cystourethrography, dantrolene sodium (Dantrium) therapy was instituted. Follow-up studies have shown this drug to be effective in treating this disorder.
D003620:Dantrolene / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D006827:Hydantoins / Q000627:therapeutic use*; D008297:Male; D013035:Spasm / Q000188:drug therapy; D014521:Urethra / Q000502:physiology; D014525:Urethral Stricture / Q000188:drug therapy*; D001743:Urinary Bladder / Q000502:physiology; D001750:Urinary Bladder, Neurogenic / Q000188:drug therapy; D014555:Urination Disorders / Q000188:drug therapy*
D006827:Hydantoins; D003620:Dantrolene