title: A matrix method for calculating recurrence risks of unilocal disorders for genetic counselling.
abstract: A matrix method to calculate conditional likelihoods in a pedigree and use them to determine recurrence risks for unilocal disorders in genetic risks is presented in this paper. Different matrices are assigned to individual members of the pedigree and combined into matrix expressions. The method is explained for X-linked recessive conditions and autosomal dominant conditions with incomplete penetrance.
mesh_terms: D005260:Female; D005799:Genes, Dominant; D005808:Genes, Recessive; D005817:Genetic Counseling; D030342:Genetic Diseases, Inborn / Q000453:epidemiology*; D006801:Humans; D008297:Male; D008396:Maryland; D009154:Mutation; D010375:Pedigree; D011336:Probability; D012008:Recurrence