The influence of prostaglandin E2 on the electroencephalogram of normal subjects and epileptic patients.
In 1973 R.C. Lyneham and others warned against the possible epileptogenic effect of prostaglandins. We studied the influence of this substance on the electroencephalogram of 53 subject (31 non-epileptics and 22 epileptics) before and during the administration of PG E2. Forty-eight tracings remained unchanged, four showed a slight improvement and one showed some worsening during infusion of PG E2. One patient, suffering from daily psychomotor attacks had, accidentally a fit during the trial. It can be concluded that PG E2 does not alter the electroencephalogram in a significant way and that it does not induce epileptic seizures.
D004827:Epilepsy / Q000139:chemically induced*; D005260:Female; D006801:Humans; D008297:Male; D011247:Pregnancy; D011458:Prostaglandins E / Q000494:pharmacology*
D011458:Prostaglandins E