[Pathomorphologic changes in the organs of rats following chronic inhalation exposure to liquid polyethylsiloxane].
A chronic 90-day inhalation of polyethylsiloxane fluid at a concentration of 10 and 2 mg/m3 produced local irritation and general toxic effect on rats. Local irritation induced catarrhal-desqueamative tracheitis that was accompanied by a microfocal interstitial process in the lungs. The general toxic effect gave rise to interstitial myocarditis that was followed by focal cardiosclerosis and dystrophic lesions of vascular walls and areas of liver parenchyma. Changes in the thymus-lymph system and adrenal structure suggested prolonged protective tension of the animal body. A chronic 90-day inhalation of polyethylsiloxane at a concentration of 0.2 mg/m3 brought about no pathological lesions in the microstructure of animal organs.
D000311:Adrenal Glands / Q000473:pathology; D000818:Animals; D001808:Blood Vessels / Q000473:pathology; D001980:Bronchi / Q000473:pathology; D002540:Cerebral Cortex / Q000473:pathology; D007668:Kidney / Q000473:pathology; D008297:Male; D008407:Mast Cells / Q000648:ultrastructure; D009206:Myocardium / Q000473:pathology; D051381:Rats; D012828:Silicones / Q000506:poisoning*; D012833:Siloxanes / Q000506:poisoning*; D014132:Trachea / Q000473:pathology
D012828:Silicones; D012833:Siloxanes
Patomorfologicheskie izmeneniia v organakh krys pri khronicheskom ingaliatsionnom vozdeĭstvii poliétilsiloksanovoĭ zhidkosti