Effect of leukocytic endogenous mediator (LEM) on zinc absorption in the rat.
Leukocytic endogenous mediator (LEM) was shown to produce a significant increase in the intestinal absorption of zinc within 7 hr after its administration to normal rats. Consistent with earlier studies, LEM also produced a significant decrease in the plasma zinc concentration and an increased hepatic uptake of this metal which further demonstrates that LEM may be a key intermediate in altering zinc homeostasis during inflammation.
D000818:Animals; D005753:Gastric Mucosa / Q000378:metabolism; D007408:Intestinal Absorption; D008099:Liver / Q000378:metabolism*; D008297:Male; D009504:Neutrophils / Q000378:metabolism*; D011506:Proteins / Q000494:pharmacology*; D011817:Rabbits; D051381:Rats; D015032:Zinc / Q000378:metabolism*
D011506:Proteins; D015032:Zinc