DNA-mediated transformation in the platyfish-swordtail melanoma system.
A genetic marker, the tumor gene Tu, which causes the formation of abnormal melanophores, the T-melanophores, in the skin of Xiphophorine fish has been transferred by donor DNA from a Tu genotype to recipient embryos lacking Tu. Abnormal melanophores which are identical to the T-melanophores of the donor genotype occurred only in recipients treated with Tu-DNA and not in those treated with Tu-free control DNA.
D000818:Animals; D004247:DNA; D005399:Fishes / Q000196:embryology; D005796:Genes; D008545:Melanoma / Q000235:genetics*; D008547:Melanophores; D009374:Neoplasms, Experimental / Q000235:genetics; D012878:Skin Neoplasms / Q000235:genetics*; D014170:Transformation, Genetic
D004247:DNA