Cortisol and GH responses to D- and L-amphetamine in monkeys.
Equimolar doses of D-amphetamine and L-amphetamine, and a water placebo were injected intravenously on different days into rhesus monkeys, and their plasma cortisol and GH responses were determined over a 3-hour period. D- and L-amphetamine (but not the placebo) equally suppressed plasma cortisol concentration and equally increased plasma GH concentration. Pretreatment of the monkeys with large doses of pimozide, a specific dopamine receptor blocker, did not appear to block the hormonal responses to either isomer of amphetamine. The results suggest that the hormonal responses to both D- and L-amphetamine were mediated by noradrenergic neurones stimulatory to GH and inhibitory to ACTH, and that D- and L-amphetamine exert equipotent noradrenergic effects in the neuroendocrine system.
D000661:Amphetamine / Q000494:pharmacology*; D000818:Animals; D003913:Dextroamphetamine / Q000494:pharmacology; D005260:Female; D013006:Growth Hormone / Q000097:blood*; D006854:Hydrocortisone / Q000097:blood*; D008032:Limbic System / Q000378:metabolism; D008253:Macaca mulatta; D008297:Male; D010868:Pimozide / Q000494:pharmacology
D010868:Pimozide; D013006:Growth Hormone; D000661:Amphetamine; D003913:Dextroamphetamine; D006854:Hydrocortisone