[Effect of long-term vitamin A administration on the acid fastness and biochemical properties of erythrocytes].
A long-term administration of retinol in a dose exceeding 15-fold the diurnal requirement to rats weighing 170-200 g provoked a diminution of the erythrocytes resistance to an acid hemolytic, an intensified uptake of glucose, and increased activity of glycolytic enzymes (hexokinase, aldolase, phosphohexoisomerase), accumulation of lactate, along with changes in the redox enzymes activity, suppression of the catalase and intensification of peroxidase activity. The content of microergic nucleotides and electrolites (Na+ and K+) remained unchanged.
D000818:Animals; D004912:Erythrocytes / Q000187:drug effects* / Q000201:enzymology / Q000378:metabolism; D051381:Rats; D014801:Vitamin A / Q000494:pharmacology*
D014801:Vitamin A
Vliianie dlitel'nogo vvedeniia vitamina A na killotnuiu rezistentnost' i biokhimicheskie svoĭstva éritrotsitov