title: Pathologic correlations in a case of complete heart block with split His potentials resulting from a stab wound of the heart.
abstract: A 23 year old previously healthy man was stabbed in the anterior chest. This resulted in a ventricular septal defect and complete atrioventricular (A-V) block. The electrocardiogram revealed complete A-V block with a QRS pattern of right bundle branch block. His bundle recordings 26 days later revealed A-V dissociation with split His potentials (P-H1 interval of 100 msec and H2-V interval of 40 msec). During the study the escape QRS shifted from right to left bundle branch block with H2 potentials still preceding each QRS interval with H2-V intervals of 40 msec. A permanent pacemaker was implanted because of persistent congestive heart failure and bradycardia due to A-V block. The patient subsequently became asymptomatic. He died suddenly 3 1/2 years later. Pathologically there were sizable openings in both the tricuspid and mitral valve substance and a ventricular septal defect involving the pars membranacea and part of the adjacent muscular septum. Serial sections of the conduction system revealed total destruction and fibrous replacement of the bifurcation and beginning of the right and left bundle branches and subtotal fibrous replacement of the branching bundle. Thus, the bifurcation of the bundle of His was totally absent at autopsy despite apparent electrophysiologic evidence of its existence 26 days after the stab wound. A possible explanation for this discrepancy is the subsequent fibrosis of the bifurcation produced by hemodynamic changes at the lower margin of the ventricular septal defect.
mesh_terms: D000200:Action Potentials; D000328:Adult; D002036:Bundle of His / Q000293:injuries*; D002037:Bundle-Branch Block / Q000209:etiology; D004562:Electrocardiography; D006327:Heart Block / Q000209:etiology* / Q000473:pathology; D006329:Heart Conduction System / Q000293:injuries* / Q000473:pathology; D006335:Heart Injuries / Q000150:complications* / Q000473:pathology; D006346:Heart Septum / Q000293:injuries / Q000473:pathology; D006351:Heart Valves / Q000473:pathology; D006801:Humans; D008297:Male; D010138:Pacemaker, Artificial; D014951:Wounds, Stab / Q000150:complications* / Q000473:pathology