[Galanthamine interaction with mouse brain acetylcholinesterase in in vivo experiments].
Armine treatment of mice against the background of preliminary galanthamine injection diminished the inhibition of the acetylcholinesterase of the brain caused by a reversible inhibitor. This effect was connected with the acetylcholine accumulation and the displacement by it of galanthamine from the active centres of the enzyme. Thus, a competitive character of galanthamine-acetylcholinesterase interaction was shown in vivo.
D000818:Animals; D001921:Brain / Q000201:enzymology*; D002800:Cholinesterase Inhibitors; D004347:Drug Interactions; D005702:Galantamine / Q000494:pharmacology*; D051379:Mice; D009578:Nitrobenzenes / Q000494:pharmacology; D009943:Organophosphorus Compounds / Q000494:pharmacology*
D002800:Cholinesterase Inhibitors; D009578:Nitrobenzenes; D009943:Organophosphorus Compounds; D005702:Galantamine
Izuchenie osobennosteĭ vzaimodeĭstviia galantamina s atsetilkholinésterazoĭ mozga v opytakh in vivo