In vivo percutaneous penetration of corticoids in man and unresolved problems in their efficacy.
This paper review the percutaneous penetration of corticosteroids in vivo in man utilizing urinary excretion of 14C-hydrocortisone as the experimental method. In general corticosteroids are only minimally absorbed from most areas of glabrous skin. Increasing the amount that penetrates-by use of occlusion-and increasing concentration provides the most practical method currently available for increasing efficacy in treatment-resistant dermatoses. Some practical research problems relevant to topical corticoid efficacy are discussed.
D000096:Acetone; D000287:Administration, Topical; D000305:Adrenal Cortex Hormones / Q000378:metabolism*; D001681:Biological Assay; D001682:Biological Availability; D004121:Dimethyl Sulfoxide; D004126:Dimethylformamide; D006207:Half-Life; D006801:Humans; D006854:Hydrocortisone / Q000008:administration & dosage / Q000378:metabolism* / Q000652:urine; D007271:Injections, Intradermal; D007275:Injections, Intravenous; D008744:Methylamines; D014677:Pharmaceutical Vehicles; D011409:Propylene Glycols; D012867:Skin / Q000378:metabolism; D013997:Time Factors; D014508:Urea
D000305:Adrenal Cortex Hormones; D008744:Methylamines; D014677:Pharmaceutical Vehicles; D011409:Propylene Glycols; D000096:Acetone; D004126:Dimethylformamide; D014508:Urea; D006854:Hydrocortisone; D004121:Dimethyl Sulfoxide