Effect of hypercapnia and hypocapnia on myocardial blood flow and performance in anaesthetized dogs.
The effects of hypercapnia and hypocapnia on haemodynamics, coronary blood flow, and lactate metabolism were evaluated in anaesthetized closed chest dogs. Coronary flow increased with increased pCO2 and oxygen consumption and left ventricular performance were well maintained. Hypocapnia reduced coronary flow, oxygen consumption, and left ventricular functional performance.
D000758:Anesthesia; D000818:Animals; D002245:Carbon Dioxide / Q000097:blood*; D003326:Coronary Circulation; D004285:Dogs; D005260:Female; D006439:Hemodynamics; D007773:Lactates / Q000378:metabolism; D008297:Male; D009200:Myocardial Contraction; D009206:Myocardium / Q000378:metabolism*; D010100:Oxygen / Q000097:blood; D010101:Oxygen Consumption; D011773:Pyruvates / Q000378:metabolism
D007773:Lactates; D011773:Pyruvates; D002245:Carbon Dioxide; D010100:Oxygen