Posthyperventilation apnea associated with severe hypoxemia.
We studied a 14-year-old girl who suffered fractures of her mandible and tegmen following a fall from a balance beam. Thirteen days after hospitalization, she developed severe, protracted, recurrent episodes of hyperventilation; subsequently, she suffered posthyperventilation apnea, which at times was prolonged and association with severe hypoxemia with an arterial oxygen pressure as low as 25 mm Hg. The patient was treated with added dead space and chlorpromazine hydrochloride (Thorazine). Postulated mechanisms for her disorder are discussed. The importance of close clinical and laboratory observation in similar cases is stressed.
D000293:Adolescent; D001049:Apnea / Q000209:etiology*; D001784:Blood Gas Analysis; D002746:Chlorpromazine / Q000627:therapeutic use; D005260:Female; D006801:Humans; D006985:Hyperventilation / Q000150:complications* / Q000209:etiology / Q000628:therapy; D000860:Hypoxia / Q000209:etiology*; D008337:Mandibular Fractures / Q000150:complications; D011602:Psychophysiologic Disorders / Q000188:drug therapy / Q000209:etiology; D012121:Respiration, Artificial; D012887:Skull Fractures / Q000150:complications
D002746:Chlorpromazine