Effect of an antiandrogen on the lymphoid system.
A side-effect of the administration of cyproterone acetate, an antiandrogenic steroid, to newborn, juvenile or adult male mice (in doses comparable to those used clinically) was found in a marked reduction of the white pulp of the spleen and reduced weight or even absence of the thymus.
D000367:Age Factors; D000818:Animals; D000831:Animals, Newborn; D003534:Cyproterone / Q000494:pharmacology*; D008297:Male; D051379:Mice; D009929:Organ Size / Q000187:drug effects; D013091:Spermatogenesis / Q000187:drug effects; D013154:Spleen / Q000187:drug effects*; D013737:Testis / Q000187:drug effects*; D013950:Thymus Gland / Q000187:drug effects*
D003534:Cyproterone