title: Serum concentrations and bioavailability of rifampicin and isoniazid in combination.
abstract: The bioavailability of rifampicin and isoniazid from formulations containing these drugs in combination has been compared to that from formulations containing either drug alone. No formulation-related differences in either rates or extent of bioavailability were found after administration of each formulation. Mean peak serum concentrations of rifampicin (8.2-11.7 mug/ml) occurring 2 to 4 h after doses of 600 mg, and isoniazid (3.6-4.8 mug/ml) occurring 0.5 to 1 h after doses of 300 mg, were similar to those reported in the literature.
mesh_terms: D000293:Adolescent; D000328:Adult; D001682:Biological Availability; D004338:Drug Combinations; D005260:Female; D006207:Half-Life; D006801:Humans; D007538:Isoniazid / Q000008:administration & dosage / Q000097:blood*; D008297:Male; D008875:Middle Aged; D012293:Rifampin / Q000008:administration & dosage / Q000097:blood*
chemical_list: D004338:Drug Combinations; D007538:Isoniazid; D012293:Rifampin