Splanchnic vascular responses to the infusion of prostaglandins A1, A2 and B1.
The effects of PGA1, PGA2 and PGB1 on the vasculature of the liver and small intestine were studied in 73 dogs. Infusions were made into a branch of the superior mesenteric artery, the hepatic artery, portal vein or femoral vein. They decreased systemic arterial pressure and dilated the hepatic arterial and prehepatic splanchnic (small intestinal) vascular beds, PGA being most active. Dilator response was not decreased by beta-adrenergic blockade. Compounds appear to be inactivated by liver and decreased systemic pressure less when infused directly into liver circulation. Dilator response was transient, particulary in small intestine, and abated or even converted to constriction when infusion was continued for a period of time. Intrahepatic portal venous vasculature appeared to be constricted by PGA.
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D004285:Dogs; D007421:Intestine, Small / Q000098:blood supply*; D008099:Liver / Q000098:blood supply*; D008102:Liver Circulation / Q000187:drug effects*; D011169:Portal Vein / Q000187:drug effects; D011453:Prostaglandins / Q000494:pharmacology*; D011454:Prostaglandins A / Q000494:pharmacology*; D012039:Regional Blood Flow / Q000187:drug effects; D014655:Vascular Resistance / Q000187:drug effects
D011453:Prostaglandins; D011454:Prostaglandins A