Kinetic and metabolic studies of 15-methyl-prostaglandin F2alpha administered intra-amniotically for induction of abortion.
The metabolism of tritium labeled 15-methyl-PGF2alpha, administered intra-amniotically, was studied in seven cases of mid-trimester abortion. The disappearance of the compound from the amniotic sac was a very slow process. A metabolite, dinor-15-methyl-PGF2alpha, was found in small amounts in the amniotic and kidney. Plasma levels of 15-methyl-PGF2alpha in the maternal circulation were determined.
D000028:Abortion, Induced; D000650:Amnion; D000653:Amniotic Fluid / Q000378:metabolism; D005260:Female; D005333:Fetus / Q000378:metabolism; D006207:Half-Life; D006801:Humans; D007267:Injections; D010920:Placenta / Q000378:metabolism; D011247:Pregnancy; D011262:Pregnancy Trimester, Second; D011460:Prostaglandins F / Q000008:administration & dosage / Q000378:metabolism* / Q000627:therapeutic use
D011460:Prostaglandins F