title: Muscle changes in acromegaly.
abstract: Muscle biopsy specimens were obtained from 18 patients with acromegaly of varying degrees of severity. Half the specimens showed hypertrophy of type 1 fibres, while atrophy was most often seen in type 2 fibres. A direct correlation between muscle appearances and growth hormone levels was not observed. The needle biopsy technique is particularly suitable for determining the natural history of acrometalic myopathy.
mesh_terms: D000172:Acromegaly / Q000097:blood / Q000473:pathology*; D000328:Adult; D000368:Aged; D001284:Atrophy / Q000473:pathology; D001707:Biopsy, Needle; D005260:Female; D013006:Growth Hormone / Q000097:blood; D006801:Humans; D006984:Hypertrophy / Q000473:pathology; D008297:Male; D008875:Middle Aged; D009132:Muscles / Q000473:pathology*
chemical_list: D013006:Growth Hormone