title: Abnormalities of sodium excretion and other disorders of renal function in fulminant hepatic failure.
abstract: Renal function was evaluated in 40 patients with fulminant hepatic failure, They were divided into two groups on the basis of glomerular filtration rates greater than 40 ml/min or less than 25 ml/min. A number of patients in group 1 had markedly abnormal renal retention of sodium together with a reduced free water clearance and low potassium excretion which could be explained by increased proximal tubular reabsorption of sodium. The patients in group 2 had evidence that renal tubular integrity was maintained when the glomerular filtration rate was greater than or equal ml/min (functional renal failure), but evidence of tubular damage was present when this was less than 3 ml/min (acute tubular necrosis).
mesh_terms: D000293:Adolescent; D000328:Adult; D005260:Female; D005919:Glomerular Filtration Rate; D006501:Hepatic Encephalopathy / Q000150:complications / Q000378:metabolism / Q000503:physiopathology*; D006801:Humans; D007668:Kidney / Q000378:metabolism / Q000503:physiopathology*; D008297:Male; D008875:Middle Aged; D011188:Potassium / Q000652:urine; D012964:Sodium / Q000378:metabolism* / Q000652:urine
chemical_list: D012964:Sodium; D011188:Potassium