Partial purification of rabbit aorta contracting substance-releasing factor and inhibition of its activity by anti-inflammatory steroids.
Rabbit aorta contracting substance-releasing factor (RCS-RF) is found in perfusates from guinea pig lungs during anaphylaxis. It has been identified as a small peptide which releases arachidonic acid from lung tissue, thus generating prostaglandin endoperoxides and tbromboxanes and causing bronchocconstriction. Anti-inflammatory steroids block the release of arachidonate by RCS-RF. In this activity their relative potency is very similar to their relative anti-inflammatory potency, suggesting that the two actions may be related.
D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology*; D001095:Arachidonic Acids / Q000378:metabolism; D006168:Guinea Pigs; D006880:Hydroxy Acids / Q000378:metabolism; D036341:Intercellular Signaling Peptides and Proteins; D008168:Lung / Q000032:analysis* / Q000201:enzymology / Q000378:metabolism; D008297:Male; D010455:Peptides / Q000302:isolation & purification*; D011453:Prostaglandins / Q000378:metabolism; D011714:Pyrans / Q000378:metabolism; D011817:Rabbits
D000893:Anti-Inflammatory Agents; D001095:Arachidonic Acids; D006880:Hydroxy Acids; D036341:Intercellular Signaling Peptides and Proteins; D010455:Peptides; D011453:Prostaglandins; D011714:Pyrans; C013236:RCS-RF