title: Structural basis of ventricular arrhythmias in human myocardial infarction: a hypothesis.
abstract: The present study was undertaken using light and electron microscopic techniques to determine whether Purkinje fibers survive in the subendocardial region of anteroseptal infarcts in humans. Tissue was obtained for this purpose from 11 patients with 12 documented infarctions at the time of autopsy; six patients died within 72 hours of the infarction and five had healed infarcts. Seven of the 11 patients had ventricular arrhythmias. Light microscopic study indicated that intact cells with a normal appearance remained on the subendocardial surface, although the underlying ventricular muscle either was necrotic or was replaced by fibrous tissue. Electron microscopy demonstrated that these intact surviving cells over the surface of the infarct had few randomly oriented myofibrils, abundant glycogen, and other characteristics of Purkinje fibers. These cells could be readily distinguished from normal or infarcted ventricular muscle cells. Purkinje fibers, the most peripheral part of the conduction system, survive in extensive anteroseptal infarcts and may be the site of origin of ventricular arrhythmias.
mesh_terms: D000818:Animals; D001145:Arrhythmias, Cardiac / Q000473:pathology* / Q000503:physiopathology; D001329:Autolysis / Q000473:pathology; D004285:Dogs; D006329:Heart Conduction System / Q000648:ultrastructure; D006352:Heart Ventricles; D006801:Humans; D009203:Myocardial Infarction / Q000473:pathology* / Q000503:physiopathology; D009206:Myocardium / Q000648:ultrastructure; D010210:Papillary Muscles / Q000648:ultrastructure; D011690:Purkinje Fibers / Q000648:ultrastructure