A diagnostic triad for portal cirrhosis.
Abnormal serum aminotransferase activities with dominance of aspartate aminotransferase over alanine aminotransferase activity, and elevated serum adenosine deaminase activity and immunoglobulin. A concentration, were commonly encountered among patients with portal cirrhosis. The full triad was present in 31 of 49 cases (63%). As isolated abnormalities, these features were not uncommon in patients with other diseases of the liver and biliary tree, but the full triad was found only in 11 of 163 such cases (6.8%). The presence of this triad in a patient with unexplained hepatomegaly is indicative of portal cirrhosis.
D000243:Adenosine Deaminase / Q000097:blood*; D000410:Alanine Transaminase / Q000097:blood*; D001219:Aspartate Aminotransferases / Q000097:blood*; D004796:Clinical Enzyme Tests; D003937:Diagnosis, Differential; D006801:Humans; D008103:Liver Cirrhosis / Q000175:diagnosis* / Q000201:enzymology; D008107:Liver Diseases / Q000175:diagnosis; D009700:Nucleoside Deaminases / Q000097:blood*
D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase; D009700:Nucleoside Deaminases; D000243:Adenosine Deaminase