title: Ultrastructural observations on differentiating human preadipocytes cultured in vitro.
abstract: A cell type, preadipocytes, isolated from the stroma of adult human adipose tissue appears capable of differentiating, in culture, into a cell with morphological features similar to that observed in terminally differentiated human adipocytes cultured under similar conditions. During this process of differentiation, preadipocytes develop extensive rough endoplasmic reticulum with prominent cisternae, the chromatin of most nuclei becomes decondensed and lipid bodies accumulate to levels observed in cultured adipocytes. Fibroblasts derived from non-adipose tissue do not undergo the same morphological changes when cultured under similar conditions.
mesh_terms: D000273:Adipose Tissue / Q000648:ultrastructure*; D002454:Cell Differentiation; D002467:Cell Nucleus / Q000648:ultrastructure; D002478:Cells, Cultured; D002843:Chromatin / Q000648:ultrastructure; D003470:Culture Media; D003594:Cytoplasmic Granules / Q000648:ultrastructure; D004721:Endoplasmic Reticulum / Q000648:ultrastructure; D005227:Fatty Acids; D005347:Fibroblasts / Q000648:ultrastructure; D006801:Humans
chemical_list: D002843:Chromatin; D003470:Culture Media; D005227:Fatty Acids