title: Barbital alteration of central nervous system sensitivity to hexobarbital in the rat.
abstract: Alteration in central nervous system (CNS) sensitivity to the hypnotic effect of the hexobarbital was assessed by analytical, electroencephalographic, and pharmacokinetic techniques in barbital-treated rats. Each of these conceptually diverse experimental methodologies yielded similar conclusions concerning the alteration of CNS sensitivity by barbital treatment.
mesh_terms: D000818:Animals; D001462:Barbital / Q000494:pharmacology*; D001463:Barbiturates / Q000494:pharmacology*; D001921:Brain / Q000378:metabolism; D002490:Central Nervous System / Q000187:drug effects*; D004361:Drug Tolerance; D004569:Electroencephalography; D006591:Hexobarbital / Q000378:metabolism / Q000494:pharmacology*; D007700:Kinetics; D008099:Liver / Q000378:metabolism; D008297:Male; D051381:Rats; D012890:Sleep / Q000187:drug effects
chemical_list: D001463:Barbiturates; D001462:Barbital; D006591:Hexobarbital