Pharmacokinetics of skin penetration.
A model for estimating in vivo skin permeability coefficients is presented. Explicit expressions are derived for the permeability coefficient in terms of excretion rates and tissue absorption. The excretion rate has a linear asymptotic limit from which the permeability coefficient can be determined. The usefulness of the model is demonstrated with existing literature data.
D000287:Administration, Topical; D001692:Biological Transport; D001702:Biopharmaceutics; D007700:Kinetics; D008433:Mathematics; D008954:Models, Biological; D010539:Permeability; D004364:Pharmaceutical Preparations / Q000378:metabolism; D012869:Skin Absorption
D004364:Pharmaceutical Preparations