Inhibition of parental tumor colony formation by cells from a semi allogeneic mixed spleen cell reaction.
Cells capable of inhibiting colony formation by the DBA/2 fibrosarcoma SaD2-AG and mammary adenocarcinoma CaD2 are generated in vitro during semiallogeneic histoincompatibility reactions between DBA/2 and (C3H/He X DBA/2)F1 hybrid spleen cells. These colony-inhibiting cells adhere strongly to plastic, develop from nonadherent precursors, and retain colony-inhibiting ability even after receiving 5,000 rads of ionizing radiation.
D000230:Adenocarcinoma / Q000276:immunology*; D000818:Animals; D002448:Cell Adhesion; D002454:Cell Differentiation / Q000528:radiation effects; D002471:Cell Transformation, Neoplastic; D002478:Cells, Cultured; D008325:Mammary Neoplasms, Experimental / Q000276:immunology*; D051379:Mice; D008811:Mice, Inbred DBA; D012513:Sarcoma, Experimental / Q000276:immunology*; D013154:Spleen / Q000166:cytology*