[Strophanthin sensitivity of animals after coronary artery occlusion and pharmacological action on adrenergic innervation of the heart].
In 95 feline experiments it was established that coronary artery occlusion does not affect the Strophantin lethal dose, but it increases the sensitivity to the arrhythmogenic effect of the cardiac glycoside after 24-48 hours. Premedication of intact animals with such a beta-adrenergic blocking agent as Anapriline (Inderal) significantly increases the toolerance of Strophantin while the stimulation of the beta-adrenergic structures with Isadrine, on the contrary, decreases the arrhythmogenic and lethal dose of Strophantin. In coronary circulation disorders the pharmacological block of the adrenergic heart innervation did not produce any significant reduction of the sensitivity to the cardiac glycoside.
D000818:Animals; D001145:Arrhythmias, Cardiac / Q000139:chemically induced; D002415:Cats; D003327:Coronary Disease; D004336:Drug Antagonism; D004357:Drug Synergism; D006321:Heart / Q000187:drug effects* / Q000294:innervation; D007545:Isoproterenol / Q000494:pharmacology; D010042:Ouabain / Q000494:pharmacology* / Q000633:toxicity; D011433:Propranolol / Q000494:pharmacology
D010042:Ouabain; D011433:Propranolol; D007545:Isoproterenol
Chuvstvitel'nost' zhivotnykh k strofantinu posle okkliuzii koronarnoĭ arterii i farmakologicheskikh vozdeistviĭ na adrenergicheskuiu