[Stomach motility and lyspafen].
Studies of motility of the stomach in 10 test-persons resulted in a significant reduction of motility after a 2-day period of perorally intake of Lyspafen. The active motoric substance is diffenoxin-hydrochloride. An addition of 0,025 mg Atropin sulfate could increase the effect. The effect is independent of the clinical diagnose. A "runaway" could be explained by an intolerance against lactose. The waves of type I are less influenced, such as the frequency of the waves of contraction.
D001285:Atropine / Q000494:pharmacology*; D004157:Diphenoxylate / Q000031:analogs & derivatives; D004338:Drug Combinations; D004341:Drug Evaluation; D005769:Gastrointestinal Motility / Q000187:drug effects*; D006801:Humans; D007540:Isonipecotic Acids / Q000494:pharmacology*
D004338:Drug Combinations; D007540:Isonipecotic Acids; D004157:Diphenoxylate; D001285:Atropine
Magenmotilität und Lyspafen