title: [Calcium absorption by the rat from various milks in relation to their total phosphorus and lactose contents].
abstract: The absorption of calcium corresponds to a strictly determined mechanism inhibited by phosphates and activited by carbohydrates. We investigate in what extent the absorption of milk calcium from various species has the same proceeding. 4 months old rats are given orally solutions of CaCl2 alone or in combination with sodium dihydrogen phosphate or lactose or these both compounds. We compare calcium absorption of these solutions to that of milk from woman, cow or sow, or to dilutions of these two latter milks. All these fluids are dosed so that they correspond each other by their respective content in total calcium, total phosphorus and lactose. Each solution contains 45Ca. Blood samples 1,30, 4, 6 and 24 hours after ingestion allow establishing the variations of plasma radioactivity. Rats are sacrified after 24 hours. In certain cases, samples from digestive tube contents and feces provide a coefficient of calcium absorption. The osseous retention is obtained from femur radioactivity. In breif, we may consider that milks from cow and sow provide calcium the absorption of which is settled after their respective content of total phosphorus and lactose. Opposed effects of these inhibitors and activators of calcium absorption compensate so that calcium from these milks is just a little better utilized by adult rat than calcium from an isocalcic solution of CaCl2. Calcium from woman milk, rich in carbohydrates, poor in total phosphorus is better absorbed than that from the two latters, however less than we might expect from its high lactose content. We may wonder that calcium utilization from cow milk is as moderate as that of a solution of CaCl2. But skeleton mineralization which may be fulfilled by milk is made better because of that: it is not chloride but calcium phosphate which ensures this mineralization, a phosphate which alone would impair this mineralization without the compensative role of lactose.
mesh_terms: D000818:Animals; D001842:Bone and Bones / Q000378:metabolism; D002118:Calcium / Q000378:metabolism*; D002122:Calcium Chloride / Q000378:metabolism; D002130:Calcium Phosphates / Q000378:metabolism; D002417:Cattle; D005243:Feces / Q000032:analysis; D005260:Female; D006801:Humans; D007408:Intestinal Absorption; D007785:Lactose / Q000032:analysis / Q000378:metabolism; D008892:Milk / Q000032:analysis; D008895:Milk, Human / Q000032:analysis; D010710:Phosphates / Q000378:metabolism; D010758:Phosphorus / Q000032:analysis; D011247:Pregnancy; D051381:Rats; D013045:Species Specificity; D013552:Swine
chemical_list: D002130:Calcium Phosphates; D010710:Phosphates; D010758:Phosphorus; D007785:Lactose; D002122:Calcium Chloride; D002118:Calcium
vernacular_title: L'Absorption, par le rat, du calcium de divers laits examinée en fonction de leur teneur en phosphore total et en lactose