Effect of calcium infusions of serum calcium and gastric acid secretion.
37 patients were studied with calcium infusions. Of these, 20 had previously undergone truncal vagotomy and pyloroplasty for duodenal ulcer disease, and 17 were unoperated patients with duodenal ulcer disease. Calcium was given intravenously either at a dose of 5 mg/kg/h for 3 h, or 4 mg/kg/h for 4 h. Gastric juice was collected by continuous suction. Results showed the 3-hour infusion raised calcium more than the 4-hour infusion. Top serum calcium achieved, however, did not correlate with calcium-stimulated gastric acid output, either with or without vagotomy. Stimulated gastric acid secretion was markedly less with vagotomy than without. It is suggested that the level of gastric acid stimulated by infusions might discriminate complete, from incomplete, vagotomies better than insulin, and that the 4-hour infusion is safer.
D002118:Calcium / Q000097:blood / Q000494:pharmacology*; D004381:Duodenal Ulcer / Q000503:physiopathology / Q000601:surgery; D005750:Gastric Juice / Q000378:metabolism*; D005753:Gastric Mucosa / Q000378:metabolism*; D005755:Gastrins / Q000097:blood; D006801:Humans; D012636:Secretory Rate / Q000187:drug effects; D013268:Stimulation, Chemical; D014628:Vagotomy
D005755:Gastrins; D002118:Calcium