Alkaloids of Thalictrum. XV. Isolation and identification of the hypotensive alkaloids of the root of Thalictrum lucidum.
Sixteen alkaloids, namely homoaromoline, obaberine, O-methyl-thalicberine, oxyberberine, thalidasine, thaliglucinone, thalrugosine, obamegine, oxyacanthine, berberine, columbamine, jatrorrhizine, magnoflorine, palmatine, thalifendine and base A chloride, plus the artifact, 8-trichloromethyldihydroberberine, were isolated from the alkaloid fraction of the roots of Thalictrum lucidum L. Of these, obamegine, thalrugosine, O-methylthalicberine, thaliglucinone, obaberine and homoaromoline were found to possess hypotensive activity in normotensive dogs. Thalidasine, homoaromoline, thalrugosine, thaliglucinone, obamegine, jatrorrhizine, and columbamine were found to possess antimicrobial activity against Mycobacterium smegmatis at a concentration of 100 mug/ml or less.
D000470:Alkaloids / Q000032:analysis* / Q000494:pharmacology; D000818:Animals; D000900:Anti-Bacterial Agents / Q000032:analysis / Q000302:isolation & purification / Q000494:pharmacology; D001599:Berberine / Q000031:analogs & derivatives / Q000032:analysis; D001794:Blood Pressure / Q000187:drug effects*; D004285:Dogs; D008826:Microbial Sensitivity Tests; D009161:Mycobacterium / Q000187:drug effects; D010946:Plants, Medicinal / Q000032:analysis*
D000470:Alkaloids; D000900:Anti-Bacterial Agents; D001599:Berberine