[Experiments on the toxicity of intra-ocular administered Gentamycin (author's transl)].
The compatibility with Gentamycin solution used for irrigation of the anterior chamber of the eye was studied in experiments performed on rabbits. The degree of damage was measured by counting the number of the undestroyed cells of the corneal endothelium after perfusion. We compared the number of undestroyed cells after perfusion with 0.25% Gentamycin solution, 0.50% Gentamycin solution and Ringer solution. The result of these experiments showed a clear reduction of the endothelial cells using a 0.50% solution of Gentamycin. On the other hand there was not found any considerable difference between the number of cells using a 0.25% solution of Gentamycin or using Ringer solution. Using both solutions there was only a very slight degree of damage to be observed.
D000867:Anterior Chamber; D003315:Cornea / Q000187:drug effects; D005839:Gentamicins / Q000008:administration & dosage / Q000009:adverse effects*; D006801:Humans; D007507:Therapeutic Irrigation
D005839:Gentamicins
Untersuchungen zur schädigenden Wirkung von intraokular appliziertem Gentamycin