beta-Adrenoceptor blocking activity and duration of action of pindolol and propranolol in healthy volunteers.
The beta-adrenoceptor blocking activities of pindolol and propranolol have been investigated in healthy male volunteers. Pindolol was about forty times more potent than propranolol in reducing isoprenaline-induced tachycardia. Pindolol (5 mg) and propranolol (u99 mg) were approximately equiactive in reducing exercise-induced tachycardia, 2 h after oral administration. The duration of action of pindolol is significantly longer than that of propranolol; 24 h after pindolol (kmg), 36+/-5% of the masimum effect were still present, and after propranolol (100 mg) 16+/-4% remained. Despite the long duration of action of pindolol, there was no evidence for cumulation during oral administration of 5 mg t.d.s. for 5 days.
D000328:Adult; D004305:Dose-Response Relationship, Drug; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D007545:Isoproterenol / Q000037:antagonists & inhibitors*; D008297:Male; D005082:Physical Exertion; D010869:Pindolol / Q000494:pharmacology*; D010919:Placebos; D011433:Propranolol / Q000494:pharmacology*; D012146:Rest
D010919:Placebos; D011433:Propranolol; D010869:Pindolol; D007545:Isoproterenol