[Cellelectrophoretic studies of the effect of methylglyoxal-bis-guanylhydrazone on blood cells of tumour patients (author's transl)].
The effect of methylglyoxal-bis-guanylhydrazone has been studied on the electrophoretic mobility of blood cells of 10 unselected and untreated patients with preferably solid malignant diseases. Prior to the incubation with CH3-G the electrophoretic mobility of lymphocytes and erythrocytes showed increased and of platelets showed decreased rates which extend over a larger range than usual and for which reasons cannot be given till now. The incubation with CH3-G caused a concentration-dependent reduction of the electrophoretic mobility of all three tested types of blood cells. This can be estimated as an impairment of a function of surface membrane and confirms recently obtained results of activity of CH3-G on platelets' surface membrane.
D001773:Blood Cells / Q000187:drug effects*; D001792:Blood Platelets / Q000187:drug effects; D004912:Erythrocytes / Q000187:drug effects; D005260:Female; D006146:Guanidines / Q000494:pharmacology*; D006801:Humans; D008214:Lymphocytes / Q000187:drug effects; D008297:Male; D008935:Mitoguazone / Q000494:pharmacology* / Q000627:therapeutic use; D009369:Neoplasms / Q000097:blood / Q000188:drug therapy*
D006146:Guanidines; D008935:Mitoguazone
Zellelektrophoretische Studie über den Effekt von Methylglyoxal-bis-guanylhydrazon auf Blutkörpe rchen von Krebspatienten