Effect of age and sex on histamine-induced gastric secretion in laboratory rats.
The effect of age and sex on histamine-stimulated 24-hr gastric secretion was assessed in the rat. Secretion tests were done in rats of both sexes at 3, 6, 9, 12, 18, and 24 mo of age. The highest 24-hr volume and acid output of gastric secretion was found in both sexes in the 9-mo age group. When related to body weight the highest 24-hr gastric secretion and acid output was found in 6-mo-old males and in 9-mo-old females. This observation may have practical value when the rat is selected as an experimental tool for the study of gastric secretory function.
D000367:Age Factors; D000818:Animals; D001835:Body Weight; D005260:Female; D005750:Gastric Juice / Q000378:metabolism*; D006632:Histamine / Q000494:pharmacology*; D008297:Male; D051381:Rats / Q000502:physiology*; D012737:Sex Factors; D013270:Stomach / Q000187:drug effects
D006632:Histamine