The appearance of nonlinear deposits of immunoglobulins in Goodpasture's syndrome.
A twenty year old woman presented with pulmonary hemorrhage and glomerulonephritis with linear deposition of IgG on the glomerular capillary basement membrane, and high titer of antiglomerular basement membrane antibody in her serum. Without treatment, renal function, which was transiently impaired, has improved, pulmonary hemorrhage subsided, and repeat renal biopsies have revealed the appearance of nonlinear in addition to the linear deposition of IgG on the glomerular capillary basement membrane in the face of diminished serum antiglomerular basement membrane antibody titer.
D000328:Adult; D019867:Anti-Glomerular Basement Membrane Disease / Q000276:immunology* / Q000473:pathology; D000906:Antibodies; D000936:Antigen-Antibody Complex; D001485:Basement Membrane / Q000276:immunology / Q000473:pathology; D005260:Female; D006801:Humans; D007074:Immunoglobulin G; D007136:Immunoglobulins; D007678:Kidney Glomerulus / Q000276:immunology / Q000473:pathology; D012075:Remission, Spontaneous
D000906:Antibodies; D000936:Antigen-Antibody Complex; D007074:Immunoglobulin G; D007136:Immunoglobulins