Rolling hairpin model for replication of parvovirus and linear chromosomal DNA.
A novel, quasicircular scheme is proposed for the replication of parvovirus DNA. Daughter strands are initiated after the copying and rearrangement of a terminal palindromic sequence, a process termed 'hairpin transfer'. Such a process may be involved in the replication of other viruses and host cell DNA.
D001483:Base Sequence; D002875:Chromosomes / Q000378:metabolism; D004261:DNA Replication; D004277:DNA, Single-Stranded / Q000096:biosynthesis* / Q000378:metabolism; D004279:DNA, Viral / Q000096:biosynthesis* / Q000378:metabolism; D008915:Minute Virus of Mice / Q000378:metabolism*; D008954:Models, Biological; D010321:Parvoviridae / Q000378:metabolism*; D014779:Virus Replication
D004277:DNA, Single-Stranded; D004279:DNA, Viral