Prolonged survival of AKR mice treated with the saponin adjuvant Quil A.
Treatment of AKR mice with the saponin Quil A delayed their death in spontaneous leukaemia. In vitro tests did not demonstrate any influence on infection of rat cells with Kirsten sarcoma virus. Quil A in the concentration nanogram/ml doubled the mitogen response of AKR spleen cells to lipopolysaccharide.
D000276:Adjuvants, Immunologic / Q000627:therapeutic use*; D000818:Animals; D005260:Female; D007942:Leukemia, Experimental / Q000188:drug therapy* / Q000473:pathology; D007958:Leukocyte Count; D051379:Mice; D008806:Mice, Inbred AKR; D008938:Mitosis / Q000187:drug effects; D012503:Saponins / Q000494:pharmacology / Q000627:therapeutic use*; D012513:Sarcoma, Experimental / Q000188:drug therapy
D000276:Adjuvants, Immunologic; D012503:Saponins