Quantification of studies of blood flow in growing and irradiated tumors in C3H mice.
An approach to quantification of blood flow in growing malignant tumors, by relating the specific rate of change of flow to the specific rate of change of tumor weight or volume, was discussed. This model, previously noted to hold for many animal tumors, offers a good description of blood flow in the KHT sarcoma in C3H mice. The same tumor responds to radiation therapy, and simple expressions were given of the relationship of flow per unit volume, at 2 points in time, to the original radiation dose. Since most animal tumors show a nonviable or necrotic volume, a description of the phenomenon was given for the C3H/Bi mammary carcinoma by noting that the percent of nonviable tissue approaches a limiting (asymptomic)value.
D000818:Animals; D004307:Dose-Response Relationship, Radiation; D008433:Mathematics; D051379:Mice; D008809:Mice, Inbred C3H; D008954:Models, Biological; D009336:Necrosis; D009369:Neoplasms / Q000098:blood supply* / Q000473:pathology / Q000532:radiotherapy; D012513:Sarcoma, Experimental