Experimentally induced osteoarthrosis in the temporomandibular joint of the mouse.
(1) 6-week-old ICR mice were injected daily with pharmacologic doses of triamcinolone diacetate (1.5 mg/kg body weight) for 8 consecutive weeks. (2) The temporomandibular joint served as a model for histological and histochemical examinations concerning the effect of glucocorticoid hormone upon bone and cartilage. (3) Histochemical reactions indicated a large number of lipid droplets within the peripheral vasculature. (4) Histological examinations revealed pathologic features, indicative of primary osteoarthrosis.
D000818:Animals; D002358:Cartilage, Articular / Q000187:drug effects / Q000378:metabolism / Q000473:pathology; D005260:Female; D050356:Lipid Metabolism; D008297:Male; D008335:Mandibular Condyle / Q000187:drug effects / Q000378:metabolism / Q000473:pathology; D051379:Mice; D008815:Mice, Inbred Strains; D010003:Osteoarthritis / Q000139:chemically induced* / Q000378:metabolism / Q000473:pathology; D013704:Temporomandibular Joint / Q000187:drug effects / Q000378:metabolism / Q000473:pathology*; D014221:Triamcinolone
D014221:Triamcinolone