[In vitro study on effect of body weight on deiodination of L-diiodotyrosine and L-thyroxine in liver and kidney of rats on standard diets].
The effect of body weight on the deiodination of L-di-iodotyrosine and L-thyroxin in the liver and kidney was studied in vitro in male Wistar rats of same age, but differing in weight (light and heavy, respectively), which were fed a standard diet. In the livers of the heavy animals, the deiodination of L-di-iodotyrosine and L-thyroxin was significantly lower than in those of the light animals. As to the kidneys, no such difference was observed. From a comparison with literature data it is concluded that the reduction in deiodination in the livers of the heavy animals might be due to a reduction in thyroid hormone metabolism.
D000367:Age Factors; D000818:Animals; D001835:Body Weight; D004105:Diiodotyrosine / Q000378:metabolism*; D007455:Iodine / Q000378:metabolism; D007668:Kidney / Q000378:metabolism*; D008099:Liver / Q000378:metabolism*; D008297:Male; D009929:Organ Size; D051381:Rats; D013974:Thyroxine / Q000378:metabolism*
D004105:Diiodotyrosine; D007455:Iodine; D013974:Thyroxine
Einfluss des Körpergewichts auf die Dejodierung von L-Dijodtyrosin und L-Thyroxin in Leber und Niere in vitro bei Ratten unter Standardfutter