title: Ion binding by X-537A. Equilibrium and rate of complexation of Co(2+) in methanol.
abstract: The reaction of X-537A (XH) with Co(2+) in methanol to form the complex CoX(+) has been studied fluorometrically to determine the equilibrium constant as a function of temperature. The effect of complexation on the proton NMR spectrum of the X-537A was studied to determine the kinetics of complex formation. Comparing the data for the reaction XM(+) leads to X(-) + M(2+) in methanol at 25 degrees for several M(2+) we find that the equilibrium constants increase in the order CoX(+) less than MnX(+) and span only a factor of 5 while the rate constants increase in the order NiX(+) less than CoX(+) less than MnX(+) and span a factor of more than 100.
mesh_terms: D000900:Anti-Bacterial Agents; D003035:Cobalt; D007477:Ions; D007832:Lasalocid; D000432:Methanol
chemical_list: D000900:Anti-Bacterial Agents; D007477:Ions; D003035:Cobalt; D007832:Lasalocid; D000432:Methanol