Clinical correlates of in vitro effect of adriamycin on advanced lung carcinoma.
The effect of 1.38 X 10(-5) M adriamycin on tritiated uridine incorporation was studied after 3 hours treatment of suspensions of 25 advanced human lung carcinomas in vitro. The results were correlated with the responses to clinical therapy. All tumours which showed an inhibition of uridine incorporation in vitro of more than 40% were also sensitive to clinical treatment with adriamycin.
D002478:Cells, Cultured; D004317:Doxorubicin / Q000627:therapeutic use*; D004341:Drug Evaluation / Q000379:methods; D006801:Humans; D066298:In Vitro Techniques; D008175:Lung Neoplasms / Q000188:drug therapy* / Q000378:metabolism; D012334:RNA, Neoplasm / Q000096:biosynthesis
D012334:RNA, Neoplasm; D004317:Doxorubicin