Binding of morphine by serum globulins from morphine-treated rabbits. II. Antibody nature of the binding globulins.
Data are presented which show that the increased binding of morphine by sera from rabbits which had been treated with morphine in an appropriate manner is mediated by immunoglobulins and is specific. These observations, together with findings reported in the preceding paper, suggest that morphine or one of its derivatives can evoke specific immune responses. It seems most likely that the response is evoked by a complex, formed in vivo, of a tissue or serum protein and morphine or one of its metabolites.
D000818:Animals; D000918:Antibody Specificity; D001666:Binding Sites, Antibody; D001667:Binding, Competitive; D002499:Centrifugation, Density Gradient; D005591:Chemical Fractionation; D002848:Chromatography, DEAE-Cellulose; D004587:Electrophoresis, Agar Gel; D009020:Morphine / Q000276:immunology* / Q000378:metabolism; D011817:Rabbits; D012712:Serum Globulins / Q000276:immunology / Q000378:metabolism*
D012712:Serum Globulins; D009020:Morphine