title: [Effect of 6beta-Methoxy-9beta,10alpha-pregna-4,6-diene-3,20-dione (Ro 6-1963) on the steroid reductases in rat liver].
abstract: 6beta-Methoxy-9beta,10 alpha-pregna-4,6-diene-3,20-dione inhibits the delta4-3-oxosteroid-5alpha-reduction in microsomes and the delta4-3-oxosteroid-5beta-reduction in the soluble fraction of male rat liver. The 3alpha- and 3beta-hydroxysteroid dehydrogenase are not inhibited by these substances.
mesh_terms: D058891:5-alpha Reductase Inhibitors; D000818:Animals; D003600:Cytosol / Q000201:enzymology; D006913:Hydroxysteroid Dehydrogenases / Q000378:metabolism; D007700:Kinetics; D008099:Liver / Q000201:enzymology*; D008297:Male; D008862:Microsomes, Liver / Q000201:enzymology; D010088:Oxidoreductases / Q000037:antagonists & inhibitors*; D011245:Pregnadienes / Q000494:pharmacology*; D051381:Rats
chemical_list: D058891:5-alpha Reductase Inhibitors; D011245:Pregnadienes; C012683:6 beta methoxy-9 beta,10 alpha-pregna-4,6-dien-3,20-dione; D010088:Oxidoreductases; D006913:Hydroxysteroid Dehydrogenases
vernacular_title: Wirkung von 6beta-Methoxy-9beta,10alpha-pregna-4,6-dien-3,20-dion (Ro 6-1963) auf die Steroidreduktasen in der Rattenleber