title: Further studies on the mode of action of isoprenaline on gastric secretion in the conscious rat.
abstract: 1 The effect of isoprenaline on gastric secretion evoked by various means has been studied in conscious rats provided with Pavlov and Heidenhain pouches. 2 Interdigestive acid secretion in the Pavlov pouch was reduced by isoprenaline, whereas pepsin secretion was unaltered. 3 Central vagal stimulation effected by 2-deoxy-D-glucose injection evoked a gastric secretory response that was substantially reduced by isoprenaline. 4 2-Deoxy-D-glucose increased the mobilization of gastric mucosal histamine, an effect that was prevented by isoprenaline. 5 Isoprenaline infusion alone induced a slight increase in histamine mobilization and also a considerable elevation of immunoreactive serum gastrin concentration. 6 The secretory response to food in the Pavlov pouch was almost abolished by isoprenaline. 7 Although the acid response to histamine in the Heidenhain pouch was susceptible to isoprenaline inhibition, that to methacholine was not. 8 Pepsin secretion in the Heidenhain pouch preparation stimulated by histamine or methacholine seemed to be enhanced by isoprenaline.
mesh_terms: D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D003847:Deoxyglucose / Q000494:pharmacology; D004347:Drug Interactions; D004435:Eating; D005260:Female; D005753:Gastric Mucosa / Q000378:metabolism*; D005755:Gastrins / Q000097:blood; D006632:Histamine / Q000378:metabolism / Q000494:pharmacology; D007545:Isoproterenol / Q000494:pharmacology*; D008688:Methacholine Compounds / Q000494:pharmacology; D051381:Rats; D013997:Time Factors
chemical_list: D001786:Blood Glucose; D005755:Gastrins; D008688:Methacholine Compounds; D006632:Histamine; D003847:Deoxyglucose; D007545:Isoproterenol