Excretion of Dische positive compounds in rats after irradiation and after administration of some cytostatic drugs.
In order to verify some pathophysiological aspects in radio- and chemotherapy of tumors the excretion of Dische positive compounds in rats was followed. During fractionated whole-body irradiation of animals it was found that up to the exposure with 50 R/day the organism is able to repair the disturbances provoked by irradiation for a certain time and that within the course of irradiation a permanently higher excretion of Dische positive compounds occurs. On the contrary, following the exposure of 100 R/day after a short increase continual decrease occurs lasting until the death of the animal. The excretion of Dische positive compounds in rats was followed also after the application of Cyclophosphamide, cis-dichlorodiammineplatinum (II) and Vinblastine. All these three cytostatic drugs produce an increased excretion of Dische positive compounds on the first day after the application. In the case of Cyclophosphamide, it was demonstrated that the excreted amount of Dische positive compounds was dose dependent.
D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology*; D002945:Cisplatin / Q000494:pharmacology*; D003520:Cyclophosphamide / Q000494:pharmacology; D003841:Deoxycytidine / Q000652:urine; D004305:Dose-Response Relationship, Drug; D004307:Dose-Response Relationship, Radiation; D008297:Male; D011741:Pyrimidine Nucleosides / Q000652:urine*; D011830:Radiation Effects; D051381:Rats; D014747:Vinblastine / Q000494:pharmacology; D014965:X-Rays
D000970:Antineoplastic Agents; D011741:Pyrimidine Nucleosides; D003841:Deoxycytidine; D014747:Vinblastine; D003520:Cyclophosphamide; D002945:Cisplatin