title: The thyroidal response to chronic goitrogenic stimulation and the persistence of effects of early goitrogenic stimulation.
abstract: The effects of overstimulation of the thyroid gland induced by the feeding or rapeseed meal or thiouracil during the growing period persisted for as long as 75 weeks after withdrawal of the source of goitrogen from the diet. Thyroid weight, thyroid iodine content and radioiodine uptake were all increased in birds which had received goitrogen during the growing period. Follicle diameter was greater and the height of epithelial cells was lower than in control birds. The thyroid changes in these birds were deduced to be compensatory because production characteristics were normal and distribution of a dose of radioiodine into thyronines (T3 + T4) was similar in the birds which had received goitrogen during the growing period and in the control birds. Birds which were being fed rapeseed meal at the time the thyroid gland were examined showed effects which varied in magnitude according to the length of time over which rapeseed meal had been fed. Thyroid weight, follicle diameter, amount of epithelial tissue present and the total amount of iodine in the thyroid glands increased, whereas coupling efficiency (radioiodine-labelled T3 + T4)/(monoiodotyrosine/diiodotyrosine) declined with time.
mesh_terms: D000818:Animals; D002645:Chickens; D004032:Diet; D006042:Goiter / Q000139:chemically induced*; D007455:Iodine / Q000378:metabolism; D007457:Iodine Radioisotopes; D008297:Male; D009929:Organ Size / Q000187:drug effects; D010080:Oxazoles / Q000494:pharmacology*; D013268:Stimulation, Chemical; D013961:Thyroid Gland / Q000033:anatomy & histology / Q000187:drug effects* / Q000378:metabolism; D013997:Time Factors
chemical_list: D007457:Iodine Radioisotopes; D010080:Oxazoles; D007455:Iodine