Excretion of neuraminic acid-containing trisaccharides in the urine during pregnancy.
The excretion of neuraminic acid-containing trisaccharides in the urine during the course of normal pregnancy was studied. Neuraminyl-lactose and neuraminyl-galactosyl-(l led to 4)-N-acetylglucosamine were identified, and their excretion patterns were analyzed by thin-layer and gas chromatography. A progressive increase in the outputs of these acidic oligosaccharides was observed during the course of pregnancy in all cases studied. Neuraminyl-lactose excretion increased threefold, from 13.7 +/- 1.75 to 37.1 +/- 2.56 mg/24 h, and neuraminyl-galactosyl-N-acetylglucosamine twofold, from 8.4 +/- 1.27 to 15.3 +/- 2.21 mg/24 h (Mean +/- S.E.).
D000117:Acetylglucosamine / Q000652:urine; D005260:Female; D005690:Galactose / Q000652:urine; D006801:Humans; D007785:Lactose / Q000652:urine; D009438:Neuraminic Acids / Q000652:urine*; D009844:Oligosaccharides / Q000652:urine*; D011247:Pregnancy; D014312:Trisaccharides / Q000652:urine*
D009438:Neuraminic Acids; D009844:Oligosaccharides; D014312:Trisaccharides; D007785:Lactose; D000117:Acetylglucosamine; D005690:Galactose