title: [Clinico-biochemical study of epileptic children and adolescents and their relatives].
abstract: The observations were convened in the framework of clinico-genetical study of epilepsy. It was established that in the blood serum of epileptic children and adolescents and their relatives there is an increase of general activity of LDH. With the aid of electrophoresis in agar and polyacrylamid gel it was possible to show an increase in the content of LDH-1 and a drop in LDH-3. These shifts are more expressed in the blood serum of patients and sibs, rather than in parents. It is assumed that an increase of general LDH and LDH-1 activity are conditioned by an increased membrane permeability of brain cells. There were no differences in the degree of these indices depending upon the genesis, sex and frequency of paroxysms.
mesh_terms: D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D004827:Epilepsy / Q000097:blood / Q000201:enzymology / Q000235:genetics*; D005260:Female; D006801:Humans; D007527:Isoenzymes; D007770:L-Lactate Dehydrogenase / Q000097:blood*; D008297:Male
chemical_list: D007527:Isoenzymes; D007770:L-Lactate Dehydrogenase
vernacular_title: Kliniko-biokhimicheskoe izuchenie bol'nykh épilepsieĭ deteĭ i podrostkov i ikh rodstvennikov