Hormonal control of vitellogenin synthesis in avian liver.
Estradiol induces the synthesis of vitellogenin in the avian liver. We describe the precursor-product relationship between vitellogenin and the yolk proteins phosvitin and lipovitellin. The high rate of vitellogenin synthesis is a consequence of the accumulation of a stable messenger RNA. We suggest that estradiol acts at the level of the genome by opening a hitherto non-transcribed gene.
D000818:Animals; D002645:Chickens; D004958:Estradiol / Q000494:pharmacology*; D005260:Female; D007700:Kinetics; D008074:Lipoproteins / Q000096:biosynthesis*; D008099:Liver / Q000187:drug effects / Q000378:metabolism*; D008297:Male; D008970:Molecular Weight; D010053:Ovary / Q000378:metabolism; D010441:Peptide Chain Elongation, Translational / Q000187:drug effects; D010442:Peptide Chain Initiation, Translational / Q000187:drug effects; D010446:Peptide Fragments / Q000032:analysis; D012270:Ribosomes / Q000187:drug effects / Q000378:metabolism; D014158:Transcription, Genetic / Q000187:drug effects; D014357:Trypsin; D014819:Vitellogenins / Q000096:biosynthesis*
D008074:Lipoproteins; D010446:Peptide Fragments; D014819:Vitellogenins; D004958:Estradiol; D014357:Trypsin