Primary leucocyte alkaline phosphatase deficiency in an adult with repeated infections.
An individual with repeated bacterial infections, eczema, hyperimmunoglobulin E, and a primary deficiency of leucocyte alkaline phosphatase is described. The Lap-deficient neutrophils from this patient had marginally deficient bactericidal activity particularly when challenged with high ratios of bacteria per neutrophil. Leucotactic, metabolic and morphologic features of the neutrophils from the patient were normal. Evidence is presented which contrasts this patient's condition with previously described primary or secondary deficiencies of LAP.
D000328:Adult; D000469:Alkaline Phosphatase / Q000172:deficiency*; D001424:Bacterial Infections / Q000201:enzymology*; D004485:Eczema / Q000201:enzymology; D006801:Humans; D006942:Hypergammaglobulinemia; D007073:Immunoglobulin E; D008297:Male; D009504:Neutrophils / Q000166:cytology / Q000201:enzymology* / Q000378:metabolism; D010101:Oxygen Consumption; D010641:Phenotype; D013577:Syndrome
D007073:Immunoglobulin E; D000469:Alkaline Phosphatase