[Repeated immune response in gnotobiotic rats].
Repeated immune response to diphtheria toxoid was investigated in monocontaminated rats. It was shown that repeated immunization of these animals led to a sufficiently intensive immune response by the secondary type, but it ended much earlier than in the usual animals (by the 12th day). A supposition is put forward that earlier termination of the secondary response in gnotobionts is caused by the absence in their lymph nodes of an additional differentiation of cell-precursors at the late periods of secondary immune response.
D000818:Animals; D000917:Antibody Formation; D004165:Diphtheria / Q000276:immunology*; D005856:Germ-Free Life; D007156:Immunologic Memory; D008198:Lymph Nodes / Q000276:immunology; D008297:Male; D051381:Rats; D014611:Vaccination
Osobennosti povtornogo immunnogo otveta u krys-gnotobiontov