Effect of norepinephrine on the phospholipid composition of blood plasma and red blood cells in anesthetized dogs.
The phospholipid composition of blood plasma and erythrocytes from artery, hepatic venous, and sagittal sinus blood was investigated in dogs under pentobarbital anesthesia both before and after continuous infusion of norepinephrine. Norepinephrine infusion caused a very significant increase of phosphatidylglycerol (GPG) in the erythrocytes and plasma from arterial blood. Other phospholipids were not affected by the infusion. Significant release of GPG across the brain and splanchnic area was noted both in plasma and erythrocytes prior to, but not following, norepinephrine infusion. The importance of the differences between the respective phospholipid compositions of erythrocytes and plasma is emphasized. The biologic significance of the changes of the phospholipids, particularly of GPG during stress, is discussed.
D000771:Anesthesia, Intravenous; D000818:Animals; D001158:Arteries; D003392:Cranial Sinuses; D004285:Dogs; D004912:Erythrocytes / Q000187:drug effects / Q000378:metabolism*; D006503:Hepatic Veins; D009638:Norepinephrine / Q000494:pharmacology*; D010424:Pentobarbital; D010715:Phosphatidylglycerols / Q000097:blood; D010743:Phospholipids / Q000097:blood*
D010715:Phosphatidylglycerols; D010743:Phospholipids; D010424:Pentobarbital; D009638:Norepinephrine