Hypertension mediated by the activation of the rat brain 5-hydroxytryptamine receptor sites.
5-Hydroxytryptamine (5-HT) administered intraventricularly (i.vent.) in rats produced hypertension without considerable changes in heart rate. After transsection of the spinal cord or i.vent. administration of methysergide, 5-HT failed to produce the pressor effect. Thus, the hypertension results from the activation of 5-HT receptor sites of the rat brain.
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects*; D005260:Female; D006339:Heart Rate / Q000187:drug effects; D007276:Injections, Intraventricular; D008297:Male; D008784:Methysergide / Q000008:administration & dosage / Q000494:pharmacology; D051381:Rats; D013116:Spinal Cord / Q000502:physiology
D008784:Methysergide