Persisting cyclic ovarian activity in cervical cancer after surgical transposition of the ovaries and pelvic irradiation.
The effect of surgical transposition of the ovaries on gonadal function was investigated in ten young women with carcinoma of the uterine cervix, stages I and II. Gonadotrophin-, oestradiol- and progesterone-levels were determined before and during pelvic irradiation. A control group consisted of seven patients with cervical cancer who did not undergo ovaria transposition. In the control group gonadotrophins began to rise after radiation doses of 560-2400 rad (FSH) and 1130-2600 rad (LH) respectively. The excessive secretion was not seen in patients who had ovarian lifting. Ovulatory cycles occurred during or after pelvic irradiation in seven women of the study group, either spontaneously or induced by clomiphene treatment. This indicates that transposition preceding radiotherapy is an effective means of preserving ovarian secretion in young women in whom malignancies of the pelvic region demand irradiation.
D000328:Adult; D000367:Age Factors; D002996:Clomiphene / Q000494:pharmacology; D004958:Estradiol / Q000097:blood; D005260:Female; D005640:Follicle Stimulating Hormone / Q000097:blood; D006062:Gonadotropins / Q000378:metabolism; D006801:Humans; D007986:Luteinizing Hormone / Q000097:blood; D008722:Methods; D010053:Ovary / Q000503:physiopathology / Q000601:surgery*; D010060:Ovulation / Q000187:drug effects; D010388:Pelvis; D011374:Progesterone / Q000097:blood; D013268:Stimulation, Chemical; D002583:Uterine Cervical Neoplasms / Q000532:radiotherapy*
D006062:Gonadotropins; D002996:Clomiphene; D011374:Progesterone; D004958:Estradiol; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone