[Excretion of 3,4-dimethoxy phenylethylamine in the urine of schizophrenics].
According to the hypothesis of Osmond, Harley-Mason and Smythies on abnormal methylation products in the catecholamine metabolism in schizophrenics, the excretion of 3,4-dimethoxyphenylethylamine (3,4-DMPEA) in the urine was examined in 80 patients with endogenous psychoses and in 20 normal persons. In 38% of the patients 3,4-DMPEA was found, whereas no 3,4-DMPEA was found in normal persons. When the biochemical findings obtained are correlated to the corresponding diagnoses the highest incidence of positive findings was observed in paranoid-hallucinatory schizophrenics with 71% in males and 75% in females. The signification of controls during the course of the experiments is emphasized.
D000293:Adolescent; D000328:Adult; D000368:Aged; D001714:Bipolar Disorder / Q000652:urine; D055598:Chemical Phenomena; D002621:Chemistry; D004118:Dimethoxyphenylethylamine / Q000378:metabolism / Q000652:urine*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D008956:Models, Chemical; D010627:Phenethylamines / Q000652:urine*; D012559:Schizophrenia / Q000378:metabolism / Q000652:urine*; D012560:Schizophrenia, Catatonic / Q000652:urine; D012562:Schizophrenia, Disorganized / Q000652:urine; D012563:Schizophrenia, Paranoid / Q000652:urine; D012569:Schizotypal Personality Disorder / Q000652:urine; D012737:Sex Factors
D004118:Dimethoxyphenylethylamine; D010627:Phenethylamines
Uber die Ausscheidung von 3,4-Dimethoxyphenyläthylamin im Urin von Schizophrenen