[Polyneuropathy caused by tuberculostatics. Study of motor nerve conduction in 29 patients].
The electroneurographic study in 29 patients, during treatment with isoniazid for pulmonary tuberculosis in 12 months period is reported. The patients age were between 16 and 70 years. During the study period motor nerve conduction velocity was done every two months in the median, ulnar and peroneal nerves. The statistical analysis in a 6 months period, revealed p greater than 0.05 (nonsignificant) at the median and peroneal nerves, in spite of the lowering of the motor nerve conduction in a 12 months period. The same findings were observed with the ulnar nerve, but p less than 0.01 (significant). It was impossible to establish a correlation between the motor nerve conduction velocities and the clinical findings observed in the patients. This paper, in the author's opinion, shows that the nerve motor conduction technique is worthless in the follow up of isoniazid patients.
D000293:Adolescent; D000328:Adult; D000368:Aged; D000995:Antitubercular Agents / Q000009:adverse effects; D004341:Drug Evaluation; D005260:Female; D006801:Humans; D008297:Male; D008475:Median Nerve / Q000187:drug effects; D008875:Middle Aged; D009046:Motor Neurons / Q000187:drug effects*; D009431:Neural Conduction / Q000187:drug effects*; D009461:Neurologic Manifestations; D010543:Peroneal Nerve / Q000187:drug effects; D014397:Tuberculosis, Pulmonary / Q000188:drug therapy*; D014459:Ulnar Nerve / Q000187:drug effects
D000995:Antitubercular Agents
Polineuropathisa determinadas por tuberculostaticos. Estudo da conducão nervosa motora em 29 pacientes