Influence of staphylococcal enterotoxin on water and electrolyte transport in the small intestine.
The direct and indirect effects of staphylococcal enterotoxins A and C on the flux of water, sodium, and potassium have been studied in paired Thiry Vella fistulae in dogs. Administration of toxin resulted in a significant decrease in absorption, both in the loop to which the toxin had been administered and its pair. This decrease in absorption was associated with a decrease in movement out of the lumen, movement into the lumen remaining relatively unchanged. The mechanism of action of staphylococcal enterotoxins is discussed, and comparisons made with other enterotoxins.
D000818:Animals; D001692:Biological Transport / Q000187:drug effects; D004285:Dogs; D004768:Enterotoxins / Q000494:pharmacology*; D007082:Ileum / Q000187:drug effects / Q000378:metabolism; D007408:Intestinal Absorption / Q000187:drug effects; D007421:Intestine, Small / Q000187:drug effects* / Q000378:metabolism; D007583:Jejunum / Q000187:drug effects / Q000378:metabolism; D011188:Potassium / Q000378:metabolism*; D012964:Sodium / Q000378:metabolism*; D013210:Staphylococcus; D014867:Water / Q000378:metabolism*
D004768:Enterotoxins; D014867:Water; D012964:Sodium; D011188:Potassium