[Prevention of post-transfusional malaria by sero-detection of latent Plasmodium carriers among blood donors].
The risks of post-transfusion malaria are becoming a worry and the sero-investigation of latent carriers of plasmodium, among donors, is certainly the only efficient prophylactic measure. This is the result of an investigation carried out between October 1973 and February 1975 in 18 Blood Tranfusion Centres in France. Out of 2.997 sera studied in immuno-fluorescence of malaria, 3 to 5.2% of sero-positivity have been noticed, depending on the antigen used (P. falciparum, P. malariae and P. cynomolgi bastianellii). If the presence of fluorescent antibodies --  especially at weak titers --, does not mean compulsorily that the parasitemia persists, the serologic negativity leads to a diagnosis of exclusion. In this manner, the idea of a latent malaria is eliminated and one can determine precisely which bloods will be transfused without danger. But the required condition is that the sero-diagnosis of malaria be done on homologous antigens, which is, in spite of various technical difficulties, realizable in specialized laboratories. For material reasons, these tests cannot applied to all donors who have lived overseas. In return, it would be indubitably desired that these tests be done, among these donors, on subjects belonging to rare blood groups.
D000941:Antigens / Q000032:analysis*; D001782:Blood Donors; D002353:Carrier State; D005602:France; D006801:Humans; D008288:Malaria / Q000517:prevention & control / Q000635:transmission*; D012698:Serologic Tests / Q000379:methods*; D065227:Transfusion Reaction
D000941:Antigens
Prévention du paludisme post-transfusionnel par séro-dépistage des porteurs latents de plasmodium parmi les donneurs de sang