Differential effect of raised Mg2+ concentration of K+ ion movement and on swelling in the isolated perfused rat liver poisoned by phalloidin.
The K+ release from the isolated perfused rat liver induced by phalloidin was strongly inhibited on raising the Mg2+ concentration of the perfusion medium from 0.5-40mM while, in contrast, the phalloidin induced swelling of the organ and the vasuolisation of the liver tissue was not affected.
D000818:Animals; D001692:Biological Transport / Q000187:drug effects; D056486:Chemical and Drug Induced Liver Injury / Q000378:metabolism*; D004487:Edema / Q000139:chemically induced; D066298:In Vitro Techniques; D008099:Liver / Q000378:metabolism*; D008274:Magnesium / Q000494:pharmacology*; D008297:Male; D009842:Oligopeptides / Q000506:poisoning*; D009929:Organ Size / Q000187:drug effects; D010590:Phalloidine / Q000506:poisoning*; D011188:Potassium / Q000378:metabolism*; D051381:Rats
D009842:Oligopeptides; D010590:Phalloidine; D008274:Magnesium; D011188:Potassium