Metabolism of testosterone by the epididymis and ventral prostate of rat and its inhibition by cyproterone acetate.
The metabolism of 3H-testosterone by the epididymis and accessory organs of adult male rats exposed continuously to microdoses of cyproterone acetate from subcutaneous capsules were studied. The major metabolite of 3H-testosterone in the epididymis, vas deferens and ventral prostate of control rat was dihydrotestosterone while the formation of androstanediol by these tissues was low. The highest percentage of DHT was formed by the ventral prostate and cauda epididymis. In rats exposed to cyproterone acetate for four months, the conversion of testosterone to DHT was inhibited in all the tissues but maximally in the ventral prostate and cauda epididymis. In these rats, the secretory function of the ventral prostate was normal while that of the epididymis was markedly decreased. These data are discussed based on the differential thresholds of androgens required to regulate the functions of the accessory organs.
D000818:Animals; D002369:Castration; D003534:Cyproterone / Q000494:pharmacology*; D004822:Epididymis / Q000187:drug effects / Q000378:metabolism*; D008297:Male; D009928:Organ Specificity; D011467:Prostate / Q000187:drug effects / Q000378:metabolism*; D051381:Rats; D013739:Testosterone / Q000378:metabolism*; D013997:Time Factors; D014649:Vas Deferens / Q000187:drug effects / Q000378:metabolism
D013739:Testosterone; D003534:Cyproterone