Potentiation of isoproterenol effect by ascorbic acid.
Intraduodenal administration of isoproterenol together with ascorbic acid caused a much greater increase in the heart rate and pulse pressure, and a greater decrease in the mean blood pressure of anesthetized dogs than was observed after intraduodenal administration of isoproterenol alone. No potentiating effect was observed when isoproterenol and the vitamin were injected intravenously.
D000818:Animals; D001205:Ascorbic Acid / Q000008:administration & dosage / Q000494:pharmacology*; D001794:Blood Pressure / Q000187:drug effects; D004285:Dogs; D004357:Drug Synergism; D004386:Duodenum; D005260:Female; D006339:Heart Rate / Q000187:drug effects; D007441:Intubation, Gastrointestinal; D007545:Isoproterenol / Q000008:administration & dosage / Q000494:pharmacology*; D008297:Male; D013997:Time Factors
D007545:Isoproterenol; D001205:Ascorbic Acid