Quantitative characterization of THC and ethanol interaction.
The anticonvulsant activity of ethanol, delta9-tetrahydrocannabinol and their combinations was measured in the maximal electroshock seizure test. The determined median anticonvulsant doses (ED50) of drug combinations were compared with those calculated on the assumption of additivity of doses. No significant difference was found between the determined and expected values. It is concluded that in this test ethanol and THC may interact additively.
D000818:Animals; D000927:Anticonvulsants; D004347:Drug Interactions; D004597:Electroshock; D000431:Ethanol / Q000494:pharmacology*; D008297:Male; D051379:Mice
D000927:Anticonvulsants; D000431:Ethanol