Weak inhibitory behavioral effects of postnatal! preweaning taurine injections in rats.
The behavior of rats injected once every 2 days between Postnatal Days 4 and 20 with 62.5 mug/g or 125 mug/g body weight of taurine was compared with saline- or .5 M NaCl-injected litter-mate controls. Taurine-injected rats ran significantly less in the running wheel test and displayed lower response/reinforcement ratios following step-like changes in DRL reinforcement schedules. The quicker adjustments to the changes in DRL schedules did not occur immediately but during sessions following the change. We concluded that taurine administration during early juvenile development could weakly influence adult inhibitory behavior.
D000818:Animals; D000831:Animals, Newborn / Q000254:growth & development*; D001522:Behavior, Animal / Q000187:drug effects*; D003216:Conditioning, Operant / Q000187:drug effects; D005260:Female; D008297:Male; D009043:Motor Activity / Q000187:drug effects; D051381:Rats; D012054:Reinforcement, Psychology; D013654:Taurine / Q000494:pharmacology*
D013654:Taurine