[Incorporation of 4-14C-labeled cholesterol into the cholesterol ester fractions of plasma lipoproteins in patients with cirrhosis of the liver (author's transl)].
In vivo incorporation studies with 4-14C-cholesterol were performed in five patients with cirrhosis of the liver. All patients showed low concentrations of total cholesterol, esterified cholesterol, and a low activity of the lecithin: cholesterol acyltransferase activity (LCAT). The pattern of incorporation corresponded to the results known from hypercholesterolemic, normocholesterolemic and hypertriglyceridemic patients. Low cholesterol ester concentrations and low LCAT activity do not modify the pattern of incorporation into the lipoprotein ester fractions.
D002784:Cholesterol / Q000097:blood*; D002788:Cholesterol Esters / Q000097:blood; D006801:Humans; D008074:Lipoproteins / Q000097:blood*; D008103:Liver Cirrhosis / Q000097:blood* / Q000201:enzymology; D007862:Phosphatidylcholine-Sterol O-Acyltransferase / Q000097:blood
D002788:Cholesterol Esters; D008074:Lipoproteins; D002784:Cholesterol; D007862:Phosphatidylcholine-Sterol O-Acyltransferase
Einbau von 4-14C-markiertem Cholesterol in die Cholesterol-Ester-Fraktion der Plasma-Lipoproteine bei Lebercirrhotikern