title: Stimulation of albumin synthesis by keto analogues of amino acids.
abstract: (1) The effect of ketoanalogues of branched-chain amino acids on albumin synthesis was examined in two biological systems using the [14C]carbonate technique. (2)alpha-Ketocaproic acid, the ketoanalogue of leucine, was able to reverse the reduced synthesis rate observed when isolated livers, from well-nourished animals were perfused with blood from rats deprived of dietary protein for 48 h. (3) A mixture of ketoanalogues of the three branched-chain amino acids, leucine, isoleucine and valine, was able to increase albumin synthesis per unit dry liver weight to above normal levels when administered intragastrically to rats 16 h after partial hepatectomy.
mesh_terms: D000418:Albumins / Q000096:biosynthesis*; D000818:Animals; D004044:Dietary Proteins; D006498:Hepatectomy; D007532:Isoleucine / Q000031:analogs & derivatives* / Q000494:pharmacology; D007651:Keto Acids / Q000494:pharmacology*; D007930:Leucine / Q000031:analogs & derivatives* / Q000494:pharmacology; D008099:Liver / Q000187:drug effects / Q000378:metabolism* / Q000502:physiology; D008297:Male; D051381:Rats; D013329:Structure-Activity Relationship; D014633:Valine / Q000031:analogs & derivatives* / Q000494:pharmacology
chemical_list: D000418:Albumins; D004044:Dietary Proteins; D007651:Keto Acids; D007532:Isoleucine; D007930:Leucine; D014633:Valine