Neonatal thyrotoxicosis is associated with transplacental passage of human thyroid stimulating immunoglobulin (HTSI).
A woman who developed thyrotoxicosis during pregnancy had a high level of HTSI at the time of delivery. The baby had high levels of HTSI initially but, unlike the mother, the levels fell, giving a half-life of HTSI of 10 days.
D000328:Adult; D005260:Female; D005312:Fetal Blood / Q000032:analysis; D006801:Humans; D006980:Hyperthyroidism / Q000151:congenital* / Q000188:drug therapy; D007136:Immunoglobulins / Q000032:analysis; D007223:Infant; D007231:Infant, Newborn; D007232:Infant, Newborn, Diseases / Q000209:etiology*; D008135:Long-Acting Thyroid Stimulator / Q000097:blood; D008431:Maternal-Fetal Exchange; D011247:Pregnancy; D011248:Pregnancy Complications / Q000188:drug therapy; D011433:Propranolol / Q000627:therapeutic use; D013961:Thyroid Gland / Q000276:immunology*
D007136:Immunoglobulins; D008135:Long-Acting Thyroid Stimulator; D011433:Propranolol