Stereochemical requirements for intercalation of platinum complexes into double-stranded DNA's.
The complexes 1,10-phenanthrolineethylenediamineplatinum(II) and 2,2'-bipyridineethylenediamineplatinum(II) have a planar, aromatic ligand system that facilitates intercalation, as shown by their ability to unwind closed circular duplex DNA. Nonbonded steric interactions can rotate the pryidine ligands out of the coordination plane in bis(pyridine)ethylenediamineplatinum(II), thus preventing intercalation. Fiber x-ray diffraction patterns of the two metallointeracalators indicate that the binding is governed by the neighbor exclusion principle.
D004247:DNA; D004270:DNA, Circular; D005029:Ethylenediamines; D008024:Ligands; D009690:Nucleic Acid Conformation / Q000187:drug effects*; D010618:Phenanthrolines; D010984:Platinum / Q000494:pharmacology; D011725:Pyridines; D013329:Structure-Activity Relationship; D014961:X-Ray Diffraction
D004270:DNA, Circular; D005029:Ethylenediamines; D008024:Ligands; D010618:Phenanthrolines; D011725:Pyridines; D010984:Platinum; D004247:DNA