Drug exposure and the acquisition and retention of a conditioned taste aversion.
Two experiments examined the effects of preexposure and postexposure to a drug on the acquisition and retention of a conditioned taste aversion induced by that drug. Experiment 1 demonstrated that although drug preexposure attenuated a subsequent conditioned aversion, repeated taste-drug pairings reversed the initial attenuation effect and resulted in nearly complete avoidance of consumption. Experiment 2, however, demonstrated that drug postexposure did not alter a previously established conditioned aversion, although the postexposure experiences were effective in attenuating a conditioned aversion to a second novel solution. It was suggested that conditioned aversions are mediated by ACTH and that preexposure to a drug results in tolerance to that drug, yielding a smaller ACTH response and thereby a weaker aversion.
D000818:Animals; D001362:Avoidance Learning / Q000187:drug effects*; D003214:Conditioning, Classical / Q000187:drug effects*; D003216:Conditioning, Operant / Q000187:drug effects; D004327:Drinking Behavior / Q000187:drug effects; D004361:Drug Tolerance; D005260:Female; D007274:Injections, Intraperitoneal; D008094:Lithium / Q000494:pharmacology* / Q000506:poisoning; D051381:Rats; D012153:Retention, Psychology / Q000187:drug effects; D012439:Saccharin; D013649:Taste / Q000187:drug effects*; D013997:Time Factors; D014867:Water
D014867:Water; D008094:Lithium; D012439:Saccharin