Pathologic effects of antimetabolites on the hippocampus of diet controlled mice.
Marked histological changes are observed in the hippocampi of mice maintained on a niacin deficient diet following a single injection of 3-acetylpyridine (antimetabolite of nicatinamide). Extensive neuronal damage occurs in areas H2, H3 and to a lesser degree in the dentate gyrus. The neurons appear to be shrunken, deeply basophilic and exhibit a loss of intracellular architecture. The neuronal response in pyridoxine deficient mice treated with 4-methoxypyridoxine (antimetabolite of pyridoxine) is not remarkable.
D000818:Animals; D006624:Hippocampus / Q000187:drug effects* / Q000378:metabolism / Q000473:pathology; D008297:Male; D051379:Mice; D009539:Nicotinic Acids / Q000172:deficiency*; D011736:Pyridoxine / Q000031:analogs & derivatives* / Q000494:pharmacology; D026681:Vitamin B 6 Deficiency / Q000473:pathology*
D009539:Nicotinic Acids; D011736:Pyridoxine