Study of mitomycin C-induced chromosomal exchange.
Mitomycin C-induced sister chromatic exchange and quadriradial formation were studied in chromosomes from Muntiacus muntjac fibroblasts and A9, a transformed mouse cell line. We present the first direct cytological evidence for the induction of true somatic recombination involving homologous chromosomes. Analysis of the quadriradials from Muntjac cells indicates a non-random distribution with respect to the chromosomes involved and with respect to the points of conjunction. Sister chromatid exchange and quadriradial formation may reflect the outcome of repair processes involving a high frequency of homologous exchanges in the interphase nucleus.
D000818:Animals; D002842:Chromatids / Q000187:drug effects; D003434:Crossing Over, Genetic / Q000187:drug effects; D004260:DNA Repair; D003670:Deer; D051379:Mice; D008937:Mitomycins / Q000494:pharmacology*; D011995:Recombination, Genetic / Q000187:drug effects*
D008937:Mitomycins