Antiarrhythmic effect of solvents: propylene glycol, benzyl alcohol.
Propylene glycol and benzyl alcohol, the main constituents of most solvent vehicles, display a pronounced antiarrhythmic-antifibrillatory effects, when injected intravenously into animals (dogs, rats) with spontaneous or drug-induced arrhythmias. The antiarrhythmic dose for propylene glycol amounts to 0.2-0.3 ml/kg of a 70 per cent solution and, for benzyl alcohol to 0.2-0.4 ml/kg of a 4 per cent solution in physiologic saline, respectively. Similar effects were also obtained by the combined injection of propylene glycol + benzyl alcohol, in proportions which correspond to the formulae of numerous commercial "solvents" (vehicles): 2 to 20 per cent solutions of benzyl alcohol in 70 per cent propylene glycol (0.05-0.2 ml/kg). The mechanisms which might be responsible for the antiarrhythmic activity of solvents are discussed: lengthening of the effective refractory period, local and general anaesthetic effects, changes of osmolarity. The intravenous injection of propylene glycol and/or benzyl alcohol, in high doses, produces intravascular haemolysis. Clinical investigations are recommended as to the potential, beneficial or toxic effects of drug solvents, especially upon the cardiocirculatory system.
D000818:Animals; D000889:Anti-Arrhythmia Agents / Q000494:pharmacology*; D001592:Benzyl Alcohols / Q000008:administration & dosage / Q000494:pharmacology*; D001593:Benzyl Compounds / Q000494:pharmacology*; D004285:Dogs; D005260:Female; D006461:Hemolysis; D007275:Injections, Intravenous; D008297:Male; D011409:Propylene Glycols / Q000008:administration & dosage / Q000494:pharmacology*; D051381:Rats
D000889:Anti-Arrhythmia Agents; D001592:Benzyl Alcohols; D001593:Benzyl Compounds; D011409:Propylene Glycols