The synergistic effect of calcium and prostaglandin F2alpha in second trimester abortion. A pilot study.
A clinical use of the basic science phenomenon that prostaglandin is synergistic with calcium in increasing uterine contractility has been demonstrated. Twenty-five women had midtrimester abortions induced with intraamniotic calcium gluconate followed by prostaglandin F2alpha. All patients aborted within 21 hours with minimal toxicity. The mean injection-to-abortion interval was 13.5 hours in the group of women without a preinjection laminaria and 10.1 hours in patients when a laminaria was included in the protocol.
D000028:Abortion, Induced / Q000379:methods; D000328:Adult; D002118:Calcium / Q000627:therapeutic use*; D004357:Drug Synergism; D005260:Female; D006801:Humans; D010944:Plants; D011247:Pregnancy; D011262:Pregnancy Trimester, Second; D011460:Prostaglandins F / Q000627:therapeutic use*; D013997:Time Factors
D011460:Prostaglandins F; D002118:Calcium