[Monamine oxidase activity of the brain and liver mitochondria under the action of high-pressure oxygen on animals].
The monoamine oxidase (MAO) activity with tryptamine, 5-hydroxytryptamine and noreponephrine as substrates was studied as affected by different conditions of hyperbaric oxygenation. Exposure of rats to oxygenation at 1 ati resulted in a 75% activation of the brain mitochondria. MAO activity with norepinephrine and in an insignificant increase in the activity with the other substrates. Oxygenation at 2,4 and 6 ati decreased the brain MAO activity with all the substrates. The reduciton in the activity correlated with oxygen tension increase and with exposure time. The MAO 100% inhibition observed in some animals at 4 ati and ain most animals at 6 ati. In the liver the activity changes to a less extent than in the brain. At 1 ati it is somewhat increased and at 2, 4 and 6 ati it decreases.
D000818:Animals; D001921:Brain / Q000201:enzymology; D005029:Ethylenediamines / Q000494:pharmacology; D006016:Glycolates / Q000494:pharmacology; D006931:Hyperbaric Oxygenation; D008099:Liver / Q000201:enzymology; D008297:Male; D008928:Mitochondria / Q000187:drug effects / Q000201:enzymology*; D008930:Mitochondria, Liver / Q000187:drug effects / Q000201:enzymology*; D008995:Monoamine Oxidase / Q000378:metabolism*; D010100:Oxygen / Q000097:blood / Q000494:pharmacology*; D051381:Rats; D013997:Time Factors
D005029:Ethylenediamines; D006016:Glycolates; D008995:Monoamine Oxidase; D010100:Oxygen
Monaminoksidaznaia aktivnost' mitokhondriĭ mozga i pecheni pri deĭstvii na zhivotnykh kisloroda pod povyshennym davleniem