title: [LDH isoenzymes and gastrin in achlorhydri (author's transl)].
abstract: Several haematological findings (especially the values of serum LDH and its isoenzymes) were compared with changes in the gastrin level in pernicious anaemia. While vitamin B12 substitution therapy led to normalization of the anaemia and of the enzyme levels, gastric atrophy and, hence, the elevation in serum gastrin levels remained unchanged. Determination of serum gastrin, therefore, provides a valuable tool for the verification of the diagnosis of pernicious anaemia in treated cases.
mesh_terms: D000126:Achlorhydria / Q000097:blood / Q000175:diagnosis*; D000752:Anemia, Pernicious / Q000097:blood / Q000188:drug therapy / Q000201:enzymology; D000818:Animals; D004796:Clinical Enzyme Tests; D005755:Gastrins / Q000097:blood*; D006801:Humans; D007527:Isoenzymes; D007770:L-Lactate Dehydrogenase / Q000097:blood*; D011817:Rabbits; D011863:Radioimmunoassay; D014805:Vitamin B 12 / Q000627:therapeutic use
chemical_list: D005755:Gastrins; D007527:Isoenzymes; D007770:L-Lactate Dehydrogenase; D014805:Vitamin B 12
vernacular_title: LDH-Isoenzyme und Gastrin bei Achlorhydrie