[Delayed-type hypersensitivity induced by digestive immunization and suppression of this induction by antigen-antibody complexes (author's transl)].
BALB/c mice were immunized by intragastric administration of sheep red blood cells or horse red blood cells repeated daily for 4 days. The immunized animals when skin tested with an urea extract of the corresponding antigen showed a delayed-type hypersensitivity reaction. This reaction was observed for 4 weeks after the immunization. This result demonstrates that digestive immunization may induce cellular immunity. When serum from intragastrically immunised mice containing antigen-antibody complexes was administered intraperitoneally 8 hours before the onset of digestive immunization, the subsequent delayed-type hypersensitivity reaction was suppressed or considerably depressed.
D000284:Administration, Oral; D000818:Animals; D000936:Antigen-Antibody Complex; D000941:Antigens / Q000008:administration & dosage; D004912:Erythrocytes / Q000276:immunology*; D006968:Hypersensitivity, Delayed / Q000276:immunology*; D007165:Immunosuppression Therapy; D051379:Mice; D008807:Mice, Inbred BALB C; D012882:Skin Tests
D000936:Antigen-Antibody Complex; D000941:Antigens
Induction d'une hypersensibilité cutanée retardée par immunisation par voie digestive et suppression de cette induction par les complexes antigène-anticorps