The determination of progesterone receptors in breast cancer and their relationship to estrogen receptors.
A simple method for the assay of specific progesterone receptors in breast cancer tissue is described. Progesterone receptors were detected in 63 of 74 breast cancer specimens (85%). Estrogen receptor positive tumors had a wide range of progesterone receptor concentrations, but in 77% of cases the level was above 3 fmol/mg protein. The progesterone receptor level was generally low in tumors lacking estrogen receptors, 75% of the samples having concentrations between 0 and 3 fmol/mg protein. Unlike estrogen receptors, age had no influence on the number of progesterone receptors in breast cancer tissue.
D000328:Adult; D000368:Aged; D001943:Breast Neoplasms / Q000378:metabolism*; D002467:Cell Nucleus / Q000378:metabolism; D003593:Cytoplasm / Q000378:metabolism; D005260:Female; D006801:Humans; D006854:Hydrocortisone / Q000494:pharmacology; D008875:Middle Aged; D009640:Norethindrone / Q000378:metabolism; D011374:Progesterone / Q000378:metabolism; D011485:Protein Binding; D014156:Transcortin / Q000378:metabolism
D011374:Progesterone; D014156:Transcortin; D009640:Norethindrone; D006854:Hydrocortisone