Placental prostaglandin levels in pre-eclampsia.
Pre-eclampsia is characterized by uteroplacental ischemia. Prostaglandins can alter systemic blood pressure as well as regulate blood flow to the fetoplacental unit. In the present study, levels of prostaglandin E were significantly decreased in placental tissue from pre-eclamptic patients. Prostaglandin F, a potent vasoconstrictor, was markedly elevated. These observations indicate that altered placental metabolism of prostaglandins is an important factor in the pathophysiology of pre-eclampsia.
D005260:Female; D006801:Humans; D007511:Ischemia; D010920:Placenta / Q000032:analysis* / Q000098:blood supply; D011225:Pre-Eclampsia / Q000378:metabolism*; D011247:Pregnancy; D011458:Prostaglandins E / Q000032:analysis* / Q000502:physiology; D011460:Prostaglandins F / Q000032:analysis* / Q000502:physiology
D011458:Prostaglandins E; D011460:Prostaglandins F