On the mechanism of pyrogenic action of ricin.
The incubation of rabbit white blood cells with ricin, the toxic protein of castor oil seeds, leads to the production of endogenous pyrogens. This induction can be inhibited by the antibiotics actinomycin D or cycloheximide. The results are discussed in terms of disturbed corticosteroid- and Mg2+-levels.
D000818:Animals; D002478:Cells, Cultured; D003513:Cycloheximide / Q000494:pharmacology*; D003609:Dactinomycin / Q000494:pharmacology*; D005334:Fever / Q000209:etiology; D007962:Leukocytes / Q000187:drug effects* / Q000378:metabolism; D010940:Plant Proteins / Q000494:pharmacology*; D011749:Pyrogens; D011817:Rabbits; D012276:Ricin / Q000494:pharmacology*
D010940:Plant Proteins; D011749:Pyrogens; D003609:Dactinomycin; D012276:Ricin; D003513:Cycloheximide