Comparison of stability-indicating assay methods: ultraviolet, high pressure liquid chromatography and acid dye.
Three techniques--ultraviolet, high pressure liquid chromatography (HPLC) and acid dye--were compared as stability-indicating assay methods. Investigations on six drugs (codeine phosphate, ephedrine hydrochloride, morphine sulfate, procaine hydrochloride, pyrilamine maleate and thiamine hydrochloride) indicate that HPLC is the most reliable method.
D002851:Chromatography, High Pressure Liquid; D003061:Codeine / Q000032:analysis; D004396:Coloring Agents; D004355:Drug Stability; D004809:Ephedrine / Q000032:analysis; D005470:Fluorometry; D008722:Methods; D009020:Morphine / Q000032:analysis; D011343:Procaine / Q000032:analysis; D011738:Pyrilamine / Q000032:analysis; D013056:Spectrophotometry, Ultraviolet; D013831:Thiamine / Q000032:analysis
D004396:Coloring Agents; D011343:Procaine; D009020:Morphine; D004809:Ephedrine; D011738:Pyrilamine; D003061:Codeine; D013831:Thiamine