Opposite effects of spironolactone and amiloride on potassium excretion in a patient with ascites due to liver cirrhosis.
Potassium excretion was enhanced by spironolactone and it was inhibited by amiloride in a patient with ascites. One drug's effect was counteracted by the other when they were used in combination. Individual variation in the sites of action of antikaluretic drugs might be a possible explanation for the unpredictable changes in potassium excretion induced by these agents.
D000584:Amiloride / Q000494:pharmacology*; D001201:Ascites / Q000652:urine*; D004347:Drug Interactions; D005260:Female; D006801:Humans; D008103:Liver Cirrhosis / Q000652:urine*; D008875:Middle Aged; D011188:Potassium / Q000652:urine*; D011719:Pyrazines / Q000494:pharmacology*; D013148:Spironolactone / Q000494:pharmacology*
D011719:Pyrazines; D013148:Spironolactone; D000584:Amiloride; D011188:Potassium