Canine gut receptors mediating pancreatic responses to luminal L-amino acids.
Pancreatic protein and bicarbonate outputs were measured in dogs with pancreatic fistulas receiving intravenous secretin while individual L-amino acids or mixtures of L-amino acids were perfused into proximal intestine, Both phenylalanine and tryptophan were potent stimuli of pancreatic secretion; alanine, leucine, and valine increased protein outputs but their effects were small and not statistically significant. Six other amino acids were ineffective. Tryptophan perfused together with phenylalanine augmented responses to phenylalanine; methionine, ineffective when perfused alone, did not alter responses to phenylalanine when perfused with the latter. Responses to phenylalanine perfused at concentrations above 8 mM were dependent on load and were mediated by lengths of proximal bowel greater than 10 cm.
D000409:Alanine / Q000494:pharmacology; D000596:Amino Acids / Q000494:pharmacology*; D000818:Animals; D001639:Bicarbonates / Q000378:metabolism; D004285:Dogs; D007422:Intestines / Q000502:physiology*; D007930:Leucine / Q000494:pharmacology; D008715:Methionine / Q000494:pharmacology; D010179:Pancreas / Q000378:metabolism*; D010477:Perfusion; D010649:Phenylalanine / Q000494:pharmacology; D011506:Proteins / Q000378:metabolism; D011955:Receptors, Drug / Q000502:physiology*; D012633:Secretin / Q000378:metabolism; D013268:Stimulation, Chemical; D014364:Tryptophan / Q000494:pharmacology; D014633:Valine / Q000494:pharmacology
D000596:Amino Acids; D001639:Bicarbonates; D011506:Proteins; D011955:Receptors, Drug; D012633:Secretin; D010649:Phenylalanine; D014364:Tryptophan; D008715:Methionine; D007930:Leucine; D014633:Valine; D000409:Alanine