[Effect of the combined action of rimantadin and dimethyl sulfoxide on phage reproduction].
Separate and combined action of Dimethylsulfoxid (DMSO) and Rimantadin on the reproduction of phages T--3, T--4, T--7 and lambda was studied. The maximum activation of reproduction of phages T--3 and T--7 by DMSO was observed for 6 minutes of latent period. At the same time this compound did not render the action on reproduction phages T--4 and, because they utilize cell RNA-polimerase. It was shown that DMSO stimulated the synthesis of T--3 phage DNA by action on T--3 phage RNA-polymerase. Combined application of both DMSO and Rimantadin eleminated in some degree its reciprocal effect on T--3 phage macromoelecules synthesis and complet eliminated inhibitory action of Rimantidin on infective phage T--3 production.
D000218:Adamantane / Q000031:analogs & derivatives / Q000494:pharmacology*; D001952:Bridged-Ring Compounds / Q000494:pharmacology*; D003090:Coliphages / Q000187:drug effects*; D012321:DNA-Directed RNA Polymerases / Q000378:metabolism; D004121:Dimethyl Sulfoxide / Q000494:pharmacology*; D004347:Drug Interactions; D014764:Viral Proteins / Q000096:biosynthesis; D014779:Virus Replication / Q000187:drug effects*
D001952:Bridged-Ring Compounds; D014764:Viral Proteins; D012321:DNA-Directed RNA Polymerases; D000218:Adamantane; D004121:Dimethyl Sulfoxide
Effekt kombinirovannogo deĭstviia rimantadina i dimetilsul'foksida na reproduktsiiu fagov