Metabolism of PG in man: effect of furosemide on the excretion of the main metabolite of PG F2alpha.
The excretion rates of main urinary metabolite of PG F2alpha were measured radioimmunologically in 4 healthy persons and in 13 essential hypertensives. The resting values were 9.3+/-0.73 in the former and 10.4+/-2.17 ng/min in the latter. There was no significant differences between them. The excretion of the metabolite decreased prominently after the administration of furosemide. The percent decrease was 57% in healthy persons and 70% in essential hypertension. The percent result supports that furosemide inhibit the catabolism of PG F2alpha.
D003864:Depression, Chemical; D005227:Fatty Acids / Q000652:urine*; D005665:Furosemide / Q000494:pharmacology*; D006801:Humans; D006973:Hypertension / Q000652:urine; D009318:Natriuresis / Q000187:drug effects; D011460:Prostaglandins F / Q000378:metabolism*; D011466:Prostanoic Acids / Q000652:urine*
D005227:Fatty Acids; D011460:Prostaglandins F; D011466:Prostanoic Acids; D005665:Furosemide