Induction of avidin in the chick oviduct by tissue damage. Effect of promethazine chloride, CaCl2 and hydrocortisone on local induction.
The local effect of the mechanical induction of avidin by ligature was studied in diethylstilbestrol-primed chicks. The highest induction of avidin was always found in the immediate vicinity of the silk ligature of the oviduct. The locality of the induction was highly dependent on the position of the ligature. The nonligated parts of the ligated oviduct also showed a slight avidin induction. These results indicate a strictly local effect of avidin induction by ligature. An antihistamine, promethazine chloride, has a potentiating effect on the avidin induction by ligature when administered after the ligature. On the other hand, membrane stabilization by hydrocortisone or CaCl2 did not influence the ligature-induced avidin synthesis. On the basis of these results it is concluded that the avidin induction is not mediated by histamine activation or membrane damage.
D000818:Animals; D001360:Avidin / Q000096:biosynthesis*; D002122:Calcium Chloride / Q000494:pharmacology*; D002645:Chickens; D004054:Diethylstilbestrol / Q000494:pharmacology; D005260:Female; D006854:Hydrocortisone / Q000494:pharmacology*; D010047:Ovalbumin / Q000031:analogs & derivatives*; D010057:Oviducts / Q000187:drug effects / Q000378:metabolism* / Q000502:physiology; D011398:Promethazine / Q000494:pharmacology*
D001360:Avidin; D004054:Diethylstilbestrol; D010047:Ovalbumin; D011398:Promethazine; D002122:Calcium Chloride; D006854:Hydrocortisone