[Effect of cholerogen on tissue culture cells].
A study was made of various series of cholerogen on the cultures of human continuous cells of normal (F1, Rh) and tumour nature (HeLa). Cholerogen proved to produce a marked toxic action on the cultures of F1, Rh and HeLa cells causing a reduction of the number of living cells, depression of mitotic activity, a reduction of the intensity of staining on the sum total protein and RNA, a reduction of the activity in the cells of acid phosphatase and succinic dehydrogenase, and also a reduction of production of protein-polysaccharide layer. Different cholerogens produced a different toxic action on the cells of the same type.
D000135:Acid Phosphatase / Q000378:metabolism; D000942:Antigens, Bacterial; D002478:Cells, Cultured; D003601:Cytotoxicity Tests, Immunologic; D006367:HeLa Cells; D008938:Mitosis; D011506:Proteins / Q000378:metabolism; D012313:RNA / Q000378:metabolism; D013385:Succinate Dehydrogenase / Q000378:metabolism; D014734:Vibrio cholerae / Q000276:immunology*
D000942:Antigens, Bacterial; D011506:Proteins; D012313:RNA; D013385:Succinate Dehydrogenase; D000135:Acid Phosphatase
Deĭstvie kholerogena na kletki tkanevykh kul'tur