[Effect of phenformin on fat-carbohydrate metabolism in pregnant rats].
Rats given phenphormin, an antidiabetic biguanide, from the 1st (8th) day of pregnancy displayed a fall of cholesterol, phospholipids and free fatty acids in the blood; no maldevelopment of the fetus or placenta was seen. Permissibility of prescription of biguanides during pregnancy is discussed.
D000014:Abnormalities, Drug-Induced; D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D050260:Carbohydrate Metabolism; D002784:Cholesterol / Q000097:blood; D005230:Fatty Acids, Nonesterified / Q000097:blood; D005260:Female; D050356:Lipid Metabolism; D009929:Organ Size; D010629:Phenformin / Q000494:pharmacology* / Q000633:toxicity; D010743:Phospholipids / Q000097:blood; D010920:Placenta / Q000187:drug effects; D011247:Pregnancy; D011270:Pregnancy, Animal; D051381:Rats
D001786:Blood Glucose; D005230:Fatty Acids, Nonesterified; D010743:Phospholipids; D002784:Cholesterol; D010629:Phenformin
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