title: Cardiovascular function during sustained +Gz stress.
abstract: The development of aerospace systems capable of very high levels of positive (+Gz) stress, has created a need for a better understanding of the cardiovascular responses to acceleration. Using a canine model, the heart and cardiovascular system were instrumented to continuously measure coronary blood flow, cardiac output, left ventricular and aortic root pressure, and oxygen saturation in the aorta, coronary sinus, and right ventricle. The animals were exposed to acceleration profiles up to +6 Gz, 120 s at peak G; a seatback angle of 45 degrees was simulated in some experiments. Radiopaque contrast medium was injected to visualize the left ventricular chamber, coronary vasculature, aorta, and branches of the aorta. The results suggest mechanisms responsible for arrhythmias which may occur, and subendocardial hemorrhage which has been reported in other animals.
mesh_terms: D001794:Blood Pressure; D002319:Cardiovascular System / Q000503:physiopathology*; D003326:Coronary Circulation; D004562:Electrocardiography; D006112:Gravitation; D006321:Heart / Q000503:physiopathology; D006801:Humans; D008297:Male; D013026:Space Flight; D013312:Stress, Physiological / Q000503:physiopathology*