[Effect of cycloleucine on renal uptake of dibasic amino acids and cystine].
Cycloleucinead ministration (a synthetic amino acid) to rats produces a selective hyperaminoaciduria bearing on dibasic amino acids (lysine, arginine, ornithine) and cystine. Interference of cycloleucine with tubular reabsorption of these amino acids was studied "in vitro", using rat kidney cortex slices. When dibasic amino acids and cystine are at physiological concentrations, the data indicate that cycloleucine decreases their intracellular accumulation. However, effect of cycloleucine "in vitro" is not specific whatsoever its concentration; similar results are obtained with neutral amino acids such as alpha-alanine and valine. Inhibitory effects are not modified by the presence of several amino acids in the incubation medium. The results are interpreted as evidence for a dissociation between "in vitro" cellular accumu-lation and "in vivo" transepithelial transport.
D000596:Amino Acids / Q000378:metabolism* / Q000652:urine; D000818:Animals; D001120:Arginine / Q000378:metabolism*; D003515:Cycloleucine / Q000378:metabolism*; D003553:Cystine / Q000378:metabolism*; D006801:Humans; D007668:Kidney / Q000187:drug effects / Q000378:metabolism*; D008239:Lysine / Q000378:metabolism*; D009952:Ornithine / Q000378:metabolism*; D051381:Rats
D000596:Amino Acids; D003515:Cycloleucine; D003553:Cystine; D001120:Arginine; D009952:Ornithine; D008239:Lysine
Effet de la cycloleucine sur la captation rénale des acides aminés dibasiques et de la cystine