Increased phenytoin metabolism in rabbits after phenytoin pretreatment.
The serum half-life of phenytoin in rabbits after a single intravenous dose was significantly shortened by pretreating the rabbits with daily oral doses of phenytoin. This suggests that in vivo phenytoin induces its own metabolism.
D000818:Animals; D006207:Half-Life; D010672:Phenytoin / Q000378:metabolism* / Q000494:pharmacology; D011817:Rabbits; D013997:Time Factors
D010672:Phenytoin