The effect of isoprenaline on induction of tumours by methyl nitrosourea in the salivary and mammary glands of female wistar rats.
Pretreatment of rats with isoprenaline sulphate (IPR) stimulated DNA synthesis in both salivary and mammary gland tissues. Salivary gland tumours induced by N-methyl-N-nitrosourea (MNU) were observed for the first time in rats, but occurred only in IPR-pretreated animals given MNU during the period of IPR-stimulated DNA synthesis. The cumulative index of MNU-induced mammary tumours and the number of tumours per tumour-bearing rat were increased by IPR-pretreament only if the animals received MNU during the period of IPR-stimulated DNA synthesis.
D000818:Animals; D004247:DNA / Q000096:biosynthesis; D005260:Female; D007545:Isoproterenol / Q000494:pharmacology*; D008321:Mammary Glands, Animal / Q000378:metabolism; D008325:Mammary Neoplasms, Experimental / Q000139:chemically induced*; D008770:Methylnitrosourea / Q000633:toxicity*; D009607:Nitrosourea Compounds / Q000633:toxicity*; D010307:Parotid Neoplasms / Q000139:chemically induced; D051381:Rats; D012468:Salivary Gland Neoplasms / Q000139:chemically induced*; D012469:Salivary Glands / Q000378:metabolism; D013268:Stimulation, Chemical; D013997:Time Factors
D009607:Nitrosourea Compounds; D008770:Methylnitrosourea; D004247:DNA; D007545:Isoproterenol