The electrophysiological effects of ionophore X-537A on cardiac purkinje fibres.
Using classical microelectrode techniques in canine cardiac Purkinje fibres, calcium ionophore X-537A was shown to shorten the action potential, hyperpolarizing the membrane and lowering the plateau, suggesting that intracellular calcium controls membrane permeability to potassium in this preparation.
D000200:Action Potentials / Q000187:drug effects; D000818:Animals; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D004285:Dogs; D006329:Heart Conduction System / Q000187:drug effects*; D066298:In Vitro Techniques; D007832:Lasalocid / Q000494:pharmacology*; D008564:Membrane Potentials / Q000187:drug effects; D011217:Practolol / Q000494:pharmacology; D011690:Purkinje Fibers / Q000187:drug effects* / Q000502:physiology
D000900:Anti-Bacterial Agents; D011217:Practolol; D007832:Lasalocid