Sebaceous gland inhibition from combined glucocorticoid-estrogen treatment.
Sebum production in seven hirsute women was found to be markedly inhibited by low-dosage glucocorticoid therapy, usually 5 to 10 mg of prednisone daily, combined with the cyclic administration of ethinyl estradiol, either 80mug or 100mug daily, in the form of oral contraceptive medication. The average reduction of sebum secretion was 85.7%, from a pretreatment mean value of 3.07 mg of sebum to an average treatment level of 0.44 mg.
D000328:Adult; D004967:Estrogens / Q000627:therapeutic use*; D004997:Ethinyl Estradiol / Q000627:therapeutic use; D005260:Female; D005938:Glucocorticoids / Q000627:therapeutic use*; D006628:Hirsutism / Q000188:drug therapy*; D006801:Humans; D008656:Mestranol / Q000627:therapeutic use; D011241:Prednisone / Q000627:therapeutic use; D012627:Sebaceous Glands / Q000187:drug effects*; D012629:Sebum / Q000378:metabolism*
D004967:Estrogens; D005938:Glucocorticoids; D004997:Ethinyl Estradiol; D008656:Mestranol; D011241:Prednisone