The anti-inflammatory profile of proquazone.
Proquazone, 1-isopropyl-4-phenyl-7-methyl-2(1H)-quinazolinone is an orally effective anti-inflammatory analgesic and antipyretic compound in animal models. The compound is less ulcerogenic than indomethacin in the rat and appears to potentiate the anti-inflammatory and thymus involution effects of hydrocortisone in this species. That a nonacidic nonsteroidal compound would display a spectrum of anti-inflammatory activity similar to that previously found only with acidic compounds will be the subject of further investigations.
D000700:Analgesics; D000818:Animals; D000893:Anti-Inflammatory Agents; D001172:Arthritis, Rheumatoid / Q000188:drug therapy; D005260:Female; D006099:Granuloma / Q000188:drug therapy; D007213:Indomethacin / Q000009:adverse effects / Q000627:therapeutic use; D008297:Male; D011799:Quinazolines / Q000009:adverse effects / Q000627:therapeutic use*; D051381:Rats; D013276:Stomach Ulcer / Q000139:chemically induced
D000700:Analgesics; D000893:Anti-Inflammatory Agents; D011799:Quinazolines; C011385:proquazone; D007213:Indomethacin