Radiologic and scintiscan findings in HLA-B27 negative patients with ankylosing spondylitis.
Of 189 consecutive patients seen with definite ankylosing spondylitis, 17 did not possess the transplantation antigen HLA-B27. These 17 patients had less severe radiological evidence of disease than the group as a whole, or a sub-group matched for age, sex, and duration of disease. This supports the suggestion that the HLS-B27 antigen itself may play a role in the pathogenesis of the disease, and does not serve merely as a marker for a linked immune response gene.
D000328:Adult; D005260:Female; D006680:HLA Antigens; D006649:Histocompatibility Antigens; D006801:Humans; D008297:Male; D008875:Middle Aged; D011859:Radiography; D011877:Radionuclide Imaging; D013167:Spondylitis, Ankylosing / Q000175:diagnosis / Q000000981:diagnostic imaging / Q000276:immunology*
D006680:HLA Antigens; D006649:Histocompatibility Antigens