[Investigations for using cell- and organ culture in sensibility tests for cytostatics in human ovarial-carcinomas (author's transl)].
Comparison was proved from meaning of cell culture and organ culture in therapeutic sensibility tests for cytostatics in ten human ovarial-carcinomas. The sensibility for cytostatics was determined with morphological criteria in cell culture and with the activity-patterns of some enzymes (lactate-dehydrogenase, NADH-diahorase) in organ culture. In these investigations the tumors have shown approximate conformity in the state to cytostatic-sensibility as seen with the two different methods. It seems to be possible, according to these investigations, to use enzyme-histochemical parameters from organ culture for inquiry of cytostatic-sensibility of tumors.
D000970:Antineoplastic Agents / Q000494:pharmacology* / Q000627:therapeutic use; D002462:Cell Membrane / Q000187:drug effects; D002478:Cells, Cultured / Q000187:drug effects; D005260:Female; D006801:Humans; D008854:Microscopy, Electron; D009924:Organ Culture Techniques; D010051:Ovarian Neoplasms / Q000188:drug therapy* / Q000473:pathology
D000970:Antineoplastic Agents
Untersuchungen zum Einsatz von Zell- und Organkultur bei Zytostatika-Sensibilitätstestungen an menschlichen Ovarialkarzinomen