[Response of cerebral vessels to noradrenaline under hypocapnic conditions and inhibition of prostaglandin biosynthesis].
Acute experiments were conducted on cats; vasoconstrictor action of noradrenaline on the cerebral vessels and arterial pressure were considerably depressed under conditions of hypocapnia. Inhibition of prostaglandin biosynthesis with indomethacin against the background of continuing hypocapnia promoted marked elevation of cerebrovascular resistance and of arterial pressure in response to intracarotid noradrenaline injection. A hypothetical scheme of prostaglandin participation in the regulation of the tone of the cerebral vessels in hypocapnia and adrenergic actions is presented.
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D002245:Carbon Dioxide; D002415:Cats; D002560:Cerebrovascular Circulation / Q000187:drug effects*; D006706:Homeostasis; D009638:Norepinephrine / Q000494:pharmacology*; D011453:Prostaglandins / Q000502:physiology*
D011453:Prostaglandins; D002245:Carbon Dioxide; D009638:Norepinephrine
Reaktsiia mozgovykh sosudov na noradrenalin v usloviiakh gipokapnii i ingibirovaniia biosinteza prostaglandinov