A new semisynthetic 7alpha-methoxycephalosporin, CS-1170: 7beta-((cyanomethyl)thio)acetamido)-7alpha-methoxy-3-((1-methyl-1H-tetrazol-5-yl)thio)methyl)-3-cephem-4-carboxylic acid.
The synthesis and antimicrobial activity of a new semisynthetic 7alpha-methoxycephalosporin,7beta [[(cyanomethyl)thiol]acetamidol]-7alpha-methoxy-3-[[(1-methyl-1H-tetrazol-5-yl)thio]-methyl]-3-cephem-4-carboxylic acid (CS-1170), are described. This compound shows interesting antibacterial activity when compared to cefoxitin and cephalothin.
D001419:Bacteria / Q000187:drug effects; D002440:Cefoxitin / Q000494:pharmacology; D002511:Cephalosporins / Q000032:analysis / Q000138:chemical synthesis / Q000494:pharmacology; D002512:Cephalothin / Q000494:pharmacology
D002511:Cephalosporins; D002440:Cefoxitin; D002512:Cephalothin