Patches in the livers of chimaeric mice.
Sections of adult chimaeric livers have been histochemically stained for beta-glucuronidase activity and patches of two cell populations visualized. A one-dimensional clonal analysis has been used to estimate the number of coherent clones in the adult liver. The data are consistent with a total of 9-22 million regular, coherent clones, comprising 10-34 nuclei, or a smaller number of irregular, branched coherent clones. Both of these alternatives suggest considerable cell mixing during liver morphogenesis.
D000818:Animals; D002449:Cell Aggregation; D002452:Cell Count; D002465:Cell Movement; D002467:Cell Nucleus; D002678:Chimera; D002999:Clone Cells; D005966:Glucuronidase / Q000378:metabolism; D008099:Liver / Q000166:cytology* / Q000201:enzymology / Q000254:growth & development; D051379:Mice; D008809:Mice, Inbred C3H; D008810:Mice, Inbred C57BL; D009030:Mosaicism; D009929:Organ Size
D005966:Glucuronidase