Preventive effect of riboflavin and ATP on the teratogenic effects of the phenothiazine derivative T-82.
To examine the hypothesis that the teratogenic effects of the phenothiazine derivative T-82 are due to its causing a riboflavin deficiency day 11 or 12 pregnant CB Wistar rats were each given 2,000 mg/kg T-82 po plus 100 mg/kg riboflavin ip, 12.4 mg/kg ATP ip, or both. The rates of fetal mortality and external malformations were significantly decreased in all supplementation experiments. The frequencies of cleft palate, micrognathia, and micromelia were unchanged but those of ectopic testis and hydrops fetalis were significantly increased in the group treated with T-82 and ATP on day 12.
D000014:Abnormalities, Drug-Induced / Q000517:prevention & control*; D000255:Adenosine Triphosphate / Q000008:administration & dosage / Q000494:pharmacology*; D000818:Animals; D005260:Female; D010640:Phenothiazines / Q000009:adverse effects*; D010879:Piperazines / Q000009:adverse effects; D011247:Pregnancy; D051381:Rats; D012256:Riboflavin / Q000008:administration & dosage / Q000494:pharmacology*; D012257:Riboflavin Deficiency / Q000139:chemically induced; D013723:Teratogens
D010640:Phenothiazines; D010879:Piperazines; D013723:Teratogens; C012635:T-82; D000255:Adenosine Triphosphate; D012256:Riboflavin