[Change in specific antigen binding by rabbit lymphocytes during immunization with human serum albumin].
Dynamics of specific binding of the antigen with rabbit blood lymphocytes in the process of immunization was studied by radioimmunochemical method with the use of human serum albumin, I125-labeled. Three types of response to the antigenic stimulant were revealed: biphasic with two maximal of the antigen-binding activity -- on the 5th--10th and the 15th--20th day; uniphasic -- with the maximum activity on the 15th--20th day, the absence of increase of the antigen-binding activity of blood lymphocytes and a high mean level of specific antigens; the absence of primary cell reaction to the administration of the antigen and low level of specific antibodies. A correlation was revealed between the intensity of the humoral response and the sum total amount of the immunocompetent lymphocytes entering the circulation in the course of the whole immunization period.
D000818:Animals; D000917:Antibody Formation; D000918:Antibody Specificity; D001666:Binding Sites, Antibody; D006801:Humans; D008214:Lymphocytes / Q000276:immunology*; D011817:Rabbits; D012709:Serum Albumin / Q000276:immunology*
D012709:Serum Albumin
Izmenenie spetsificheskogo sviazyvaniia antigena limfotsitami krolika v protsesse immunizatsii syvorotochnymi al'buminom cheloveka