Changes in serum and cerebrospinal fluid enzyme activity after head injury.
We studied simultaneously in serum (S) and CSF (L) the enzyme activities of GOT, GPT, LDH, ICDH, MDH, ALD, and CPK in 28 patients with head injuries divided into three groups according to the severity of the trauma. We found a correlation between severity of brain lesion and enzyme activity. The best correlation was found for SGOT, SCPK, LGOT, LLDH, LMDH and LCPK. We do not believe that enzyme activity is of prognostic value. We think that further studies should be made of the specific isoenzymes of the Central Nervous System.
D000328:Adult; D000410:Alanine Transaminase / Q000097:blood / Q000134:cerebrospinal fluid; D001219:Aspartate Aminotransferases / Q000097:blood / Q000134:cerebrospinal fluid; D001930:Brain Injuries / Q000097:blood / Q000134:cerebrospinal fluid / Q000201:enzymology*; D003402:Creatine Kinase / Q000097:blood / Q000134:cerebrospinal fluid; D005634:Fructose-Bisphosphate Aldolase / Q000097:blood / Q000134:cerebrospinal fluid; D006801:Humans; D007521:Isocitrate Dehydrogenase / Q000097:blood / Q000134:cerebrospinal fluid; D007770:L-Lactate Dehydrogenase / Q000097:blood / Q000134:cerebrospinal fluid; D008291:Malate Dehydrogenase / Q000097:blood / Q000134:cerebrospinal fluid; D008875:Middle Aged; D013997:Time Factors
D007770:L-Lactate Dehydrogenase; D008291:Malate Dehydrogenase; D007521:Isocitrate Dehydrogenase; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase; D003402:Creatine Kinase; D005634:Fructose-Bisphosphate Aldolase