title: Iodine-125-digoxin radioimmunoassay: comparison of commercial kits.
abstract: Iodine-125-digoxin radioimmunoassay kits available from Abbott Diagnostics (AD), Dade Division (D), Schwarz/Mann (SM), and Clinical Assays (CA) were evaluated with respect to assay quality. The kit accuracies did not differ significantly at 2.0 ng/ml and the interassay coefficients of variation ranged from 9% (AD) to 21.4% (CA) The accuracy for all kits above 4 ng/ml is questionable, and since serum-dilution values correlated well with undiluted serum values, the dilution method of dose quantitation is preferable for levels above 4 ng/ml. Although all the kits were adequate, for evaluating digoxin at the 2ng/ml level, the Abott kit seems to be of slightly better quality.
mesh_terms: D004077:Digoxin / Q000097:blood*; D006801:Humans; D066298:In Vitro Techniques; D007457:Iodine Radioisotopes; D011863:Radioimmunoassay / Q000295:instrumentation*
chemical_list: D007457:Iodine Radioisotopes; D004077:Digoxin