Kinetics of DNA repair synthesis in guinea-pig pancreatic slices following in vitro exposure to N-methyl-N-nitrosourethane.
In vitro exposure of guinea-pig pancreatic slices to NMUT resulted in an increase in hydroxyurea-insensitive 3H-TdR incorporation into DNA; this represents DNA repair synthesis following NMUT-induced DNA damage. The kinetics of this hydroxyurea-insensitive 3H-TdR incorporation suggest that the NMUT-induced DNA damage is largely repaired within 2 hours.
D000818:Animals; D004260:DNA Repair / Q000187:drug effects; D004261:DNA Replication / Q000187:drug effects; D006168:Guinea Pigs; D006918:Hydroxyurea / Q000494:pharmacology; D066298:In Vitro Techniques; D007700:Kinetics; D008297:Male; D009605:Nitrosomethylurethane / Q000494:pharmacology*; D010179:Pancreas / Q000378:metabolism; D014520:Urethane / Q000031:analogs & derivatives*
D014520:Urethane; D009605:Nitrosomethylurethane; D006918:Hydroxyurea