Disappearance rate of endogenous human C-peptide from blood.
Glucagon (1 mg) and glucose (60 ml of 50% solution) were infused over 60 min to three normal and one obese subjects and two insulinoma patients. Plasma C-peptide immunoreactivity (CPR) and immunoreactive insulin (IRI) increased during the infusion. Half time of CPR after cessation of the infusion was 20.1 +/- 4.0 min, and that of IRI 9.8 +/- 1.3 min, respectively. This difference partly explains the higher molar concentration in plasma of CPR than IRI.
D002096:C-Peptide / Q000097:blood*; D005934:Glucagon / Q000494:pharmacology; D005947:Glucose / Q000494:pharmacology; D006207:Half-Life; D006801:Humans; D007328:Insulin / Q000097:blood; D010455:Peptides / Q000097:blood*
D002096:C-Peptide; D007328:Insulin; D010455:Peptides; D005934:Glucagon; D005947:Glucose