3-Deacetoxy-7-(alpha-amino-1-cyclohexenylacetamido) cephalosporanic acid (SCE-100), a new semisynthetic cephalosporin. III. Comparative studies on absorption, distribution and excretion of SCE-100 and cephalexin (CEX) in laboratory animals.
3-Deacetoxy-7-(alpha-amino-1-cyclohexenylacetoamido) cephalosporanic acid (SCE-100) was compared to cephalexin with respect to absorption, tissue distribution, and urinary and biliary excretion in mice, rats, rabbits and dogs. The absorption of SCE-100 after oral administration is generally slower than that of cephalexin, but its disappearance from blood and tissues is delayed. The concentration of SCE-100 in the liver is distinctly higher than that of cephalexin. These properties of SCE-100 are most clearly manifested in rats. There is no significant difference in urinary excretion of the two cephalosporins in rabbits and dogs, while in rabbits, biliary excretion of SCE-100 is more intensive than that of cephalexin.
D000284:Administration, Oral; D000818:Animals; D002506:Cephalexin / Q000008:administration & dosage / Q000378:metabolism*; D002511:Cephalosporins / Q000008:administration & dosage / Q000378:metabolism*; D004285:Dogs; D005260:Female; D007275:Injections, Intravenous; D007408:Intestinal Absorption; D008297:Male; D051379:Mice; D011817:Rabbits; D051381:Rats; D013997:Time Factors
D002511:Cephalosporins; D002506:Cephalexin