[Effect of a polyvitamin preparation on the immune response to antibodies. Demonstration of the immunostimulating activity of propylene glycol].
Humoral antibody to sheep erythrocytes was studied by plaque forming cell and hemagglutinin assays in mice receiving a polyvitaminic preparation containing vitamins A, D, E, and C. A statistically significant increase in PFC on days 6, 12 and 18 after immunization, and an increase in hemagglutinin titers was observed in animals treated with this vitamin containing solution. These results are interpreted as an immunostimulating activity of the preparation. Nevertheless, as shown by the results obtained with each component injected separately, a major proportion of the immunostimulating activity seems to be related to propylene glycol, a simple compound contained as an hydrodispersant in the preparation. Further studies of the immunostimulating properties of propylene glycol are now in progress in our laboratory.
D000276:Adjuvants, Immunologic; D000818:Animals; D000917:Antibody Formation / Q000187:drug effects*; D001205:Ascorbic Acid / Q000494:pharmacology; D005260:Female; D007110:Immunity, Active / Q000187:drug effects*; D007274:Injections, Intraperitoneal; D007279:Injections, Subcutaneous; D051379:Mice; D011409:Propylene Glycols / Q000494:pharmacology*; D013268:Stimulation, Chemical; D014801:Vitamin A / Q000494:pharmacology; D014807:Vitamin D / Q000494:pharmacology; D014810:Vitamin E / Q000494:pharmacology; D014815:Vitamins / Q000494:pharmacology*
D000276:Adjuvants, Immunologic; D011409:Propylene Glycols; D014815:Vitamins; D014801:Vitamin A; D014807:Vitamin D; D014810:Vitamin E; D001205:Ascorbic Acid
Activité d'une préparation polyvitaminique sur la réponse immunitaire à anticorps. Mise en évidence de l'activité immuno-stimulante du propylène-glycol