title: Effects of platinum and palladium salts on parameters of drug metabolism in rat liver.
abstract: The effects of various salts of platinum of palladium were determined on the parameters of the microsomal mixed-function oxidase system from rat liver. The intraperitoneal injection of PtCl4 or Pd(NO3)2 increased the hexobarbital-induced sleeping time in vivo and generally decreased the aminopyrine demethylase and the content of cytochrome P-450 in isolated hepatic microsomes. The dietary administration of various salts of platinum or palladium for 1 wk generally decreased or had no effect on the parameters of drug metabolism by isolated microsomes and after 4 or more wk generally had no effect on, or increased, the parameters. The addition of 0.15-0.2 mM PtCl4 or 0.2-0.3 mM Pd(NO3)2 to the incubation medium (containing 5 mM MgCl2) inhibited the aminopyrine demethylase of isolated hepatic microsomes by 50%.
mesh_terms: D000633:Aminopyrine N-Demethylase / Q000378:metabolism; D000818:Animals; D004032:Diet; D008099:Liver / Q000187:drug effects / Q000378:metabolism*; D008297:Male; D008862:Microsomes, Liver / Q000201:enzymology / Q000378:metabolism; D010165:Palladium / Q000494:pharmacology*; D004364:Pharmaceutical Preparations / Q000378:metabolism*; D010984:Platinum / Q000494:pharmacology* / Q000506:poisoning / Q000627:therapeutic use; D011041:Poisoning / Q000517:prevention & control; D051381:Rats
chemical_list: D004364:Pharmaceutical Preparations; D010984:Platinum; D010165:Palladium; D000633:Aminopyrine N-Demethylase