title: Ten cases of malignant hyperthermia in Norway.
abstract: Data are presented on ten cases of anaesthesia-induced malignant hyperthermia in Norway. Seven of the patients died, three recovered. The fatal cases were all boys in the age group 11-20 years. This age and sex distribution suggests that puberty with the increase in androgens is a precipitating factor in malignant hyperthermia. One of the victims who survived was a 4 1/2-year-old pseudohermaphrodite girl with the adrenogenital syndrome. The coincidence of malignant hyperthermia in a patient with such a rare syndrome points to the excessive formation of androgens in patients with this syndrome as a predisposing factor. The indications for surgery were traumatic injuries in five cases, congenital abnormalities in three and appendicitis in two cases. These conditions in themselves may cause an increased sensitivity to suxamethonium. One patient received only hexobarbitone, halothane and suxamethonium. After the last drug jaw rigidity and temperature rise to 41.3 degrees C prompted the anaesthetist to end the anaesthetic. The fact that the patient survived proves that suxamethonium induced jaw rigidity is valuable as a warning. The absence of cardiovascular depression after procaine 3.5 g in one patient is ascribed to the correction of acidosis at the time of infusion of this drug. It is suggested that procaine should be withheld until other measures such as cooling, correction of acidosis and steroid therapy have been tried.
mesh_terms: D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000768:Anesthesia, General; D000818:Animals; D002648:Child; D003402:Creatine Kinase / Q000097:blood; D005260:Female; D006801:Humans; D006979:Hyperthermia, Induced; D008297:Male; D008305:Malignant Hyperthermia / Q000188:drug therapy / Q000401:mortality; D009664:Norway; D011229:Preanesthetic Medication; D011343:Procaine / Q000627:therapeutic use; D012737:Sex Factors; D013256:Steroids / Q000627:therapeutic use; D013514:Surgical Procedures, Operative
chemical_list: D013256:Steroids; D011343:Procaine; D003402:Creatine Kinase