title: An analysis of the effect of random and ageing mechanisms on the survival of platelets.
abstract: Human platelets survival curves make it possible to estimate two factors which could be held responsible for the disappearance of cells: a) random destruction b) ageing of the platelets. This study was devoted to non-thrombocytopenic patients with chronic vascular disease. In 40% of the cases, the platelet destruction was found to be due to normal ageing of the cells combined with a random destruction process. The estimation of both of these parameters is of interest for the clinical survey of these patients. The statistical analysis of the remaining 60% of the cases presented here has demonstrated a pure linear disappearance of the labelled platelets. This obsveration favours ageing as the cause of the destruction of the platelets.
mesh_terms: D000368:Aged; D001792:Blood Platelets; D002470:Cell Survival; D006801:Humans; D008433:Mathematics