[Insufficiency of the exocrine pancreas in Wilson's disease (author's transl)].
The function of the exocrine pancreas was examined by the secretin-pancreozymin-test in 3 patients with Wilson's disease. In all cases we found a partial insufficiency. At the time of investigation the patients were 6(7)/12, 11(6)/12 and 21 years old. The youngest one was examined before therapy with D-Penicillamin. We suppose that storage of copper in lysosomes causes a cytotoxic damage of the exocrine part of the pancreas requiring substitution therapy in advanced cases.
D000328:Adult; D002570:Ceruloplasmin / Q000032:analysis; D002648:Child; D002918:Chymotrypsin / Q000378:metabolism; D003300:Copper / Q000378:metabolism / Q000652:urine; D006527:Hepatolenticular Degeneration / Q000150:complications / Q000188:drug therapy / Q000503:physiopathology*; D006801:Humans; D008247:Lysosomes / Q000378:metabolism; D008297:Male; D010179:Pancreas / Q000378:metabolism / Q000503:physiopathology*; D010182:Pancreatic Diseases / Q000209:etiology; D010396:Penicillamine / Q000627:therapeutic use; D014357:Trypsin / Q000378:metabolism
D003300:Copper; D002570:Ceruloplasmin; D002918:Chymotrypsin; D014357:Trypsin; D010396:Penicillamine
Exokrine Pankreasinsuffizienz bei Morbus Wilson