title: The influence of disulfiram on the half life and metabolic clearance rate of diphenylhydantoin and tolbtamide in man.
abstract: Diphenylhydantoin (DPH) and tolbutamide serum levels were studied in ten volunteers before and after 4 days of disulfiram treatment. The mean DPH half life increased significantly from 11.0 +/- a.2 h to 19.0 +/- 3.3 h, and the mean DPH metabolic clearance rate decreased significantly from 51.2 +/- 17.2 ml/min to 33.9 +/- 12.0 ml/min during medication. No significant changes in the half life or metabolic clearance rate of tolbutamide was observed.
mesh_terms: D000328:Adult; D000368:Aged; D004221:Disulfiram / Q000494:pharmacology*; D004347:Drug Interactions; D005260:Female; D006207:Half-Life; D006801:Humans; D007700:Kinetics; D008297:Male; D008657:Metabolic Clearance Rate / Q000187:drug effects; D008875:Middle Aged; D010672:Phenytoin / Q000097:blood*; D014044:Tolbutamide / Q000097:blood*
chemical_list: D010672:Phenytoin; D014044:Tolbutamide; D004221:Disulfiram