title: Radiation injuries to the bowel associated with the treatment of carcinoma of the cervix.
abstract: Advances in radiation techniques and increased dosage have improved the cure rate of patients with cancer of the cervix to 65 percent. Associated with this increased dosage (betatron, 5,250 r and intracavitary 137-cesium, 4,000 r at point A) has been a serious complication incidence of 10 percent. Major intestinal complications usually become manifest within an 8 to 24 month period following radiation. Few are associated with tumor and the majority are amenable to surgical correction. Rectosigmoid stenosis is a common and frequently unrecognized complication. The 8 to 12 cm. segment of rectosigmoid, with its rigid wall and narrowed lumen, can be recognized on barium examination. The symptoms are those on incomplete obstruction and deterioration, frequently confused with tumor progression. Thirty-one patients have been treated by resection and low anterior anastomosis with relief of symptoms. Rectosigmoid stenosis progressing to necrosis, perforation, or fistula (an additional 29 patients) is treated best by the Hartmann operation as a first stage. This procedure has been less complicated than either colostomy alone or resection and anastomosis. Fifteen patients with low level rectovaginal fistula or stenosis were treated by defunctioning sigmoid colostomy. A loop transverse colostomy was unsatisfactory. Ileorectovaginal fistulas occurred in an additional six patients. Preoperative investigation should establish the presence or absence of an ileal component in all fistulas. Radiation ileitis is rare as an isolated finding but frequently is associated with severe rectosigmoid damage. Surgical treatment is seldom necessary but, if indicated (ten patients), resection appears to be preferable to bypass.
mesh_terms: D003082:Colectomy; D003092:Colitis / Q000000981:diagnostic imaging; D005260:Female; D006801:Humans; D007079:Ileitis / Q000601:surgery; D007410:Intestinal Diseases / Q000601:surgery*; D007415:Intestinal Obstruction / Q000000981:diagnostic imaging / Q000601:surgery; D007416:Intestinal Perforation / Q000000981:diagnostic imaging / Q000601:surgery; D009336:Necrosis; D011349:Proctitis / Q000000981:diagnostic imaging; D011832:Radiation Injuries / Q000601:surgery*; D011859:Radiography; D011878:Radiotherapy / Q000009:adverse effects*; D012006:Rectovaginal Fistula / Q000000981:diagnostic imaging / Q000601:surgery; D012007:Rectum / Q000601:surgery; D001747:Urinary Bladder Fistula / Q000601:surgery; D002583:Uterine Cervical Neoplasms / Q000532:radiotherapy