Surface markers of human eosinophils.
Peripheral blood eosinophils from patients with eosinophilia and from healthy subjects were studied for surface immunoglobulins, receptors for the Fc region of IgG, complement receptors, and spontaneous rosette formation with sheep and mouse erythrocytes. Eosinophils were found to have receptors for complement and for aggregated IgG, and to have the same two types of complement receptors as do lymphocytes and monocytes. Immune adherence type receptors were specific for C4 or C3b, while C3d receptors were specific for C3d but unreactive with C4. Eosinophils differed from fully mature neutrophils in that the former had C3d receptors and relatively weak immune adherence (C4 or C3b) receptors, while the later did not have the C3d receptors and had strong immune adherence receptors. Eosinophil phagocytosis of complement-receptor bound erythrocytes was dependent on the presence of IgG in the antibody coating the red blood cells; this requirement for IgG resembled that found in neutrophil phagocytosis. No surface Ig or spontaneous erythrocyte rosette formation was observed with eosinophils.
D001666:Binding Sites, Antibody; D003165:Complement System Proteins / Q000378:metabolism; D004804:Eosinophils / Q000276:immunology*; D006801:Humans; D007104:Immune Adherence Reaction; D010587:Phagocytosis; D011947:Receptors, Antigen, B-Cell / Q000032:analysis
D011947:Receptors, Antigen, B-Cell; D003165:Complement System Proteins