[Behavior of some parameters of lipid and energy metabolism. 1. Behavior of the stationary concentrations of acetyl CoA, acetoacetate and adenosine phosphates in liver, as well as oxygen consumption and P/O ratios in liver homogenates of growing rats on diets differing in fat content].
Young rats were maintained on diets differing in fat content. The determination of certain parameters of the lipid and the energy metabolism in the liver showed that a high-fat diet resulted in a reduction of the stationary level of acetyl CoA, an increase in the concentration of acetoacetate and a reduction of the adenosine triphosphate content and the so-called energy charge. In case of intact respiratory chain phosphorylation, the oxygen consumption of the respective liver homogenates was simultaneously increased. The results obtained with a high-fat diet are indicative of the attainment of a metabolic state which seems to be typical of metabolic regulations in growing rats subjected to anabolic lipometabolism.
D000090:Acetoacetates / Q000378:metabolism*; D000105:Acetyl Coenzyme A / Q000378:metabolism*; D000227:Adenine Nucleotides / Q000378:metabolism*; D000818:Animals; D001823:Body Composition; D003065:Coenzyme A / Q000031:analogs & derivatives*; D004041:Dietary Fats; D004044:Dietary Proteins; D004734:Energy Metabolism; D006128:Growth; D050356:Lipid Metabolism; D008099:Liver / Q000378:metabolism*; D008297:Male; D010085:Oxidative Phosphorylation; D010101:Oxygen Consumption; D051381:Rats
D000090:Acetoacetates; D000227:Adenine Nucleotides; D004041:Dietary Fats; D004044:Dietary Proteins; D000105:Acetyl Coenzyme A; D003065:Coenzyme A
Untersuchungen zum Verhalten einiger Kenngrössen des Lipid- und Energiestoffwechsels. 1. Mitt. Das Verhalten der stationären Konzentrationen von Acetyl-CoA, Acetoacetat und Adenosinphosphaten im Lebergewebe sowie Sauerstoffaufnahme und P/O-Quotienten in Leberhomogenaten wachsender Ratten nach Fütterung unterschiedlicher Fettdiäten