An improved synthetic route to the beta-hydroxyethyl esters of 5'-nucleotides.
A simple method is described for the preparation of the beta-hydroxyethyl esters of nucleoside 5'-phosphates by treatment of the appropriate 2',3'-isopropylidene nucleoside with 2-chloro-2-oxo-1,3-dioxaphospholane. Unambigous structural assignments were based on 13C nmr spectroscopy. Chemical shifts and 13C-31P spin-spin coupling constants are discussed.
D055598:Chemical Phenomena; D002621:Chemistry; D002855:Chromatography, Thin Layer; D004590:Electrophoresis, Paper; D009682:Magnetic Resonance Spectroscopy; D008722:Methods; D008968:Molecular Conformation; D010755:Organophosphates / Q000138:chemical synthesis*; D009943:Organophosphorus Compounds / Q000138:chemical synthesis*; D012265:Ribonucleotides
D010755:Organophosphates; D009943:Organophosphorus Compounds; D012265:Ribonucleotides