[Mechanism of the damaging effect of chloridine on white rat embryos].
A study was made of the dynamics of pathohistological changes occurring in the embryos of albino rats under conditions of a single action of teratogenic doses of daraprim of the 9th day of pregnancy. Decidual tissue proved to be the most sensitive to daraprim the first disturbances in this tissue were noted to soon as one hour after the injection. Cells of various embryonic tissues reacted to daraprim differently. Most pronounced cytotoxic effect of daraprim is seen on the embryonic mesoderm and on the extraembryonic ectoderm. A conclusion was drawn on a significant role played by hemodynamic changes associated with disturbances of decidual tissue in the mechanism of the pathogenic action of some chemical teratogens on mammalian embryos.
D000014:Abnormalities, Drug-Induced / Q000196:embryology*; D000818:Animals; D003656:Decidua / Q000473:pathology; D005260:Female; D011247:Pregnancy; D011739:Pyrimethamine; D051381:Rats
D011739:Pyrimethamine
O mekhanizme povezhdaiushchego deĭstviia khloridina na zarodyshi belykh krys