[Specific assessment of the cerebral and cardiac effects of asphyxic hypoxia. Application to the study of substances with protective activity].
The influence of asphyxia on electrocorticogram (E. Co. G.) and electrocardiogram (E. C. G.) has been studied in curarized rats. The delay between the heightening of the ST component of E. C. G. and the disappearance of E. Co. G. pattern was measured. It provided more useful information on cerebral survival during asphyxia than the only study of E. Co. G. did. This delay was increased (cerebral antihypoxic effect) after intravenous treatment with pyritinol (50 mg/kg), vincamine (5 mg/kg) or propranolol (1 mg/kg), but it was not influenced by pentobarbital (60 mg/kg).
D000818:Animals; D001237:Asphyxia / Q000503:physiopathology*; D001921:Brain / Q000503:physiopathology*; D002540:Cerebral Cortex / Q000503:physiopathology; D004562:Electrocardiography; D004569:Electroencephalography; D006321:Heart / Q000503:physiopathology*; D006439:Hemodynamics / Q000187:drug effects; D000860:Hypoxia / Q000503:physiopathology*; D008297:Male; D010424:Pentobarbital / Q000494:pharmacology; D011433:Propranolol / Q000494:pharmacology; D011746:Pyrithioxin / Q000494:pharmacology; D051381:Rats; D014748:Vinca Alkaloids / Q000494:pharmacology
D014748:Vinca Alkaloids; D011433:Propranolol; D011746:Pyrithioxin; D010424:Pentobarbital
Appréciation distincte des effets cérébraux et cardiaques d'une hypoxie asphyxique. Application à l'étude des substances à activité protectrice