Lordosis behaviour in male, female and androgenized female rats.
Sex differences in the lordodis response of adult rats to ovarian hormones were studied in a series of experiments. Male rats were less sensitive to oestradiol benzoate (OB, a single injection of 10, 100 or 1000 mug/kg or seven daily injections of 2, 10, or 50mglkg)then were female rats.  Oestradiol benzoate-primed (10 mglkg)female, but not male, rats showed dose-dependent responses to progesterone (0-4, 2-0 or 10-0 mg/kg/. male rats responded clearly to progesterone (2 mg/rat) only when primed with a high dose of OB (100 mug/rat). Display of the whole pattern of female sexual behaviour was induced in male rats by treatment with 100 mug OB and 2 mg progesterone. Female rats treated with 1 mg testosterone propionate (TP) on day 4 of life, ovariectomized as adults and tested under the same endocrine conditions as the rats described above, retained behavioural OB sensitivity but responded poorly to progesterone. Evidence is presented that ovarian secretions during development significantly modify the response of neonatally TP-treated and normal female rats to OB in adulthood.
D000818:Animals; D002369:Castration; D004305:Dose-Response Relationship, Drug; D004357:Drug Synergism; D004958:Estradiol / Q000008:administration & dosage / Q000494:pharmacology; D005260:Female; D008297:Male; D010053:Ovary / Q000502:physiology; D010812:Physical Stimulation; D011187:Posture; D011374:Progesterone / Q000494:pharmacology; D051381:Rats; D012727:Sex Characteristics / Q000187:drug effects; D012737:Sex Factors; D012726:Sexual Behavior, Animal / Q000187:drug effects; D013739:Testosterone / Q000494:pharmacology
D013739:Testosterone; D011374:Progesterone; D004958:Estradiol