title: The binding of chloramphenicol to serum proteins in patients with chronic renal insufficiency.
abstract: The binding (r) of chloramphenicol to serum proteins is significantly lower in patients with chronic renal failure than in normal subjects. Before hemodialysis, the mean r value in patients with chronic renal insufficiency was 0.165 mg/g (+/-0.003) versus 0.188 mg/g (+/-0.004) in healthy individuals. Hemodialysis produced a significant rise in r (to 0.182 mg/g, +/-0.004). Decrease in the serum concentration of albumin in patients with chronic renal insufficiency does not seem to be the sole factor responsible for decreased r.
mesh_terms: D000328:Adult; D001798:Blood Proteins / Q000378:metabolism*; D001806:Blood Urea Nitrogen; D002701:Chloramphenicol / Q000097:blood*; D003404:Creatinine / Q000097:blood; D005921:Glomerulonephritis / Q000097:blood; D006801:Humans; D007676:Kidney Failure, Chronic / Q000097:blood*; D008875:Middle Aged; D007690:Polycystic Kidney Diseases / Q000097:blood; D011485:Protein Binding; D011704:Pyelonephritis / Q000097:blood; D006435:Renal Dialysis
chemical_list: D001798:Blood Proteins; D002701:Chloramphenicol; D003404:Creatinine