A "natural" anti-HLA-A2 antibody reacting with homozygous cells.
In the serum of a young normal male, never transfused, a cold cytotoxic IgM antibody was found reacting exclusively with A2 homozygous cells on a French panel, as shown by population and family studies. This antibody needs about two to five times more lymphocytes or platelets to be absorbed than an immune anti-A2 of the same titre. The antigen recognized by this antibody seems to be covered by the same molecule as HLA-A2, according to redistribution experiments.
D000328:Adult; D000906:Antibodies / Q000032:analysis; D000918:Antibody Specificity; D001792:Blood Platelets / Q000276:immunology; D005828:Genetics, Population; D006680:HLA Antigens / Q000032:analysis; D006649:Histocompatibility Antigens / Q000032:analysis; D006720:Homozygote; D006801:Humans; D007075:Immunoglobulin M / Q000032:analysis; D008214:Lymphocytes / Q000276:immunology; D008297:Male; D010375:Pedigree
D000906:Antibodies; D006680:HLA Antigens; D006649:Histocompatibility Antigens; D007075:Immunoglobulin M