Biochemical effects of asbestiform minerals on lung fibroblast cultures.
The ability of different types of asbestiform minerals to enhance or suppress the levels of fibrous collagen in cultures of lung fibroblasts was tested. All commercially important asbestos dusts produced both effects, a lower dose favouring a fibrogenic response whereas a higher dose favoured an opposite effect.
D000818:Animals; D001194:Asbestos / Q000494:pharmacology*; D002478:Cells, Cultured; D002807:Chondroitin / Q000031:analogs & derivatives*; D003094:Collagen / Q000378:metabolism*; D004247:DNA / Q000378:metabolism*; D003871:Dermatan Sulfate / Q000378:metabolism*; D005347:Fibroblasts / Q000187:drug effects / Q000378:metabolism*; D006820:Hyaluronic Acid / Q000378:metabolism*; D006909:Hydroxyproline / Q000378:metabolism*; D008168:Lung / Q000187:drug effects / Q000378:metabolism*; D012313:RNA / Q000378:metabolism*; D011817:Rabbits
D001194:Asbestos; D003871:Dermatan Sulfate; D012313:RNA; D006820:Hyaluronic Acid; D002807:Chondroitin; D003094:Collagen; D004247:DNA; D006909:Hydroxyproline