title: Physical aspects of wet granulations I: distribution kinetics of water.
abstract: The kinetics of wetting during the process of making tablet granulations were studied; the process progresses through an intermediate (overwetted) nonequilibrium granule to a final, equilibrated granule. In systematic formulation changes, there is an optimum composition from the point of view of hardness and content of equilibrium granules.
mesh_terms: D004339:Drug Compounding; D006244:Hardness; D007700:Kinetics; D007785:Lactose; D010316:Particle Size; D011208:Powders; D013213:Starch; D013395:Sucrose; D013499:Surface Properties; D013997:Time Factors; D014867:Water
chemical_list: D011208:Powders; D014867:Water; D013395:Sucrose; D013213:Starch; D007785:Lactose