title: [Teratogenic and mutagenic studies with caffeine in the animal experiment].
abstract: Principles of teratogenic and mutagenic actions are defined. The recent experimental studies with laboratory animals, and our investigations with caffeine-sodium benzoicum and with soluble coffee in pregnant rats and mice showed no teratogenicity. The results are compared with specific teratogenic effects of cytostatic agents. A teratogenicity of caffeine can be excluded, a mutagenicity in animal experiments can also not be proved.
mesh_terms: D000014:Abnormalities, Drug-Induced / Q000209:etiology*; D000818:Animals; D000970:Antineoplastic Agents / Q000009:adverse effects; D001565:Benzoates / Q000009:adverse effects; D002110:Caffeine / Q000009:adverse effects*; D005260:Female; D007928:Lethal Dose 50; D051379:Mice; D009153:Mutagens; D051381:Rats; D013723:Teratogens
chemical_list: D000970:Antineoplastic Agents; D001565:Benzoates; D009153:Mutagens; D013723:Teratogens; D002110:Caffeine
vernacular_title: Teratogenetische und mutagenetische Untersuchungen mit Coffein im Tierexperiment