In vivo and in vitro studies of 15alpha-hydroxyprogesterone in the human placenta.
Studies were conducted to determine the fate of 15alpha-hydroxyprogesterone in human placental tissue. Tritiated 15alpha-hydroxyprogesterone was perfused through normal human placentas in situ at the time of Cesarean section and incubated with a 10,000x g microsomal supernate of the placenta in vitro. In both systems the substrate, but no additional metabolites were identified. These findings indicate that 15alpha-hydroxyprogesterone is not metabolized during its passage in the human term placenta, and suggests that because of its fetal origin clinical measurements of 15alpha-hydroxyprogesterone may provide a valuable index to the status of fetal viability.
D003460:Crystallization; D005260:Female; D005333:Fetus / Q000378:metabolism; D006801:Humans; D006908:Hydroxyprogesterones / Q000378:metabolism*; D008861:Microsomes / Q000378:metabolism; D010477:Perfusion; D010920:Placenta / Q000378:metabolism*; D011247:Pregnancy
D006908:Hydroxyprogesterones