The ralationship between changes in 5-HT induced platelet aggregation and clinical state in patients treated with fluphenazine.
Platelet aggregation responses to 5-HT and adenosine diphosphate were examined in a population of eighteen patients treated with fluphenazine decanoate for longer than one year. 5-HT induced aggregation was enhanced in ten subjects. This enhancement was similar to that previously described in patients receiving chlorpromazine. Patients who showed enhanced 5-HT induced aggregation showed less rateable psychopathology and less extrapyramidal side-effects than patients who did not show enhancement. These findings suggest that platelet aggregation responses could be used to identify patients who could be safely withdrawn from long-term neuroleptic therapy.
D000328:Adult; D002746:Chlorpromazine / Q000494:pharmacology; D005476:Fluphenazine / Q000009:adverse effects / Q000494:pharmacology*; D006801:Humans; D008875:Middle Aged; D010974:Platelet Aggregation / Q000187:drug effects*; D012559:Schizophrenia / Q000188:drug therapy; D012702:Serotonin Antagonists
D012702:Serotonin Antagonists; D005476:Fluphenazine; D002746:Chlorpromazine