title: Peculiar pharmacokinetics of brallobarbital as a source of complications in Vesparax intoxication.
abstract: 1. The rate of elimination of brallobarbital, a component of Vesparax depends on the route of administration. The half-life following oral administration is considerably longer than after intravenous injection. This corresponds with longer sleeping times. 2. The half-life of brallobarbital administered intravenously could be increased by administration of its metabolites. This suggests that a metabolite, formed especially after oral administration, is responsible for the retarded elimination of brallobarbital. 3. The presence of the other components of Vesparax, namely secobarbital and hydroxyzine also increases the half-life of brallobarbital. 4. Brallobarbital, rather than the other components of Vesparax is primarily responsible for the problems in Vesparax intoxication.
mesh_terms: D000284:Administration, Oral; D000818:Animals; D001463:Barbiturates / Q000008:administration & dosage / Q000378:metabolism*; D004338:Drug Combinations; D006207:Half-Life; D006919:Hydroxyzine / Q000008:administration & dosage / Q000378:metabolism*; D007275:Injections, Intravenous; D007700:Kinetics; D008099:Liver / Q000378:metabolism; D008297:Male; D010477:Perfusion; D010634:Phenobarbital / Q000494:pharmacology; D051381:Rats; D012631:Secobarbital / Q000008:administration & dosage / Q000506:poisoning; D012890:Sleep
chemical_list: D001463:Barbiturates; D004338:Drug Combinations; D012631:Secobarbital; D006919:Hydroxyzine; C012790:brallobarbital; D010634:Phenobarbital