Serum and lung tissue levels of cephradine in thoracic surgery.
Serum and lung tissue levels in fifteen patients who underwent thoracic surgery were determined by the agar-diffusion plate method after i.m. administration of cephradine (500 mg). The mean value of the serum level 30 to 120 min after administration was 6.5 mug/ml, the mean lung tissue level was 2.6 mug/g. The lung tissue levels reached 40% of the simultaneous serum level. Four patients received cephradine for the treatment of post-operative chest infections. This antibiotic has an important therapeutic role in cases of thoracic-surgical infections.
D000328:Adult; D001682:Biological Availability; D002511:Cephalosporins / Q000032:analysis*; D002515:Cephradine / Q000032:analysis* / Q000097:blood / Q000627:therapeutic use; D005260:Female; D006801:Humans; D008168:Lung / Q000032:analysis* / Q000601:surgery; D008297:Male; D008875:Middle Aged; D013530:Surgical Wound Infection / Q000188:drug therapy; D013903:Thoracic Surgery; D013909:Thorax / Q000601:surgery
D002511:Cephalosporins; D002515:Cephradine