Quantitation in plasma and urine of acebutolol and a major metabolite with preliminary observations on their disposition kinetics in man.
An acetyl-homologue-metabolite, present in concentrations of up to ten times those of the unchanged drug, in the plasma of patients receiving oral doses of acebutolol, is reported. Combined gas chromatography--mass spectrometry has been utilized to determine the structure of the acetyl-metabolite. This acetyl-metabolite has been measured as acebutolol by previously published non-specific methods for the determination of acebutolol in biological fluids. A specific and sensitive gas chromatographic method is described for the separate quantitation of acebutolol and its acetyl-metabolite in plasma and urine. Using our method, preliminary data on the disposition kinetics of acebutolol are presented. The difficulties in interpreting previously published pharmacokinetic data for acebutolol, based on a non-specific method of analysis, are emphasized.
D000070:Acebutolol / Q000097:blood / Q000378:metabolism* / Q000652:urine; D000085:Acetates / Q000032:analysis; D000368:Aged; D002849:Chromatography, Gas; D006801:Humans; D013058:Mass Spectrometry; D008875:Middle Aged
D000085:Acetates; D000070:Acebutolol