title: Role of hormonal factors in the pathogenesis of postmenopausal osteoporosis.
abstract: In 47 women with postmenopausal osteoporosis, pretreatment studies by microradiography, radioimmunoassay and other methods showed increased bone resorption, normal bone formation, and decreased serum immunoreactive parathyroid hormone (PTH). In patients treated with a physiologic replacement dose of estrogen, bone resorption decreased to normal and PTH increased after short-term therapy; bone formation decreased to very low levels after long-term therapy. These data indicate that, in most patients, both an intrinsic abnormality of bone cell function and a disruption of the normal regulation of bone turnover by PTH and sex hormones, as a result of the menopause, are important in the pathogenesis of osteoporosis.
mesh_terms: D001862:Bone Resorption; D004967:Estrogens / Q000378:metabolism / Q000502:physiology* / Q000627:therapeutic use; D005260:Female; D006062:Gonadotropins / Q000097:blood; D006801:Humans; D008593:Menopause; D010024:Osteoporosis / Q000188:drug therapy / Q000209:etiology* / Q000378:metabolism; D010281:Parathyroid Hormone / Q000097:blood / Q000502:physiology*; D013739:Testosterone / Q000378:metabolism / Q000502:physiology*
chemical_list: D004967:Estrogens; D006062:Gonadotropins; D010281:Parathyroid Hormone; D013739:Testosterone