title: 1,8-disubstituted analogues of (Ile5) and (Val5)angiotensin II: difference in potency and specificity of angiotensin II-antagonistic activity.
abstract: Depending on the species, position 5 in angiotensin II is occupied by isoleucine or valine. 1,8-disubstituted analogues of [Ile5]angiotensin II show distinct differences from the corresponding [Val5]angiotensin II analogues in the potency and specificity of their inhibitory action. The syntheses of new analogues are described.
mesh_terms: D000804:Angiotensin II / Q000031:analogs & derivatives* / Q000037:antagonists & inhibitors* / Q000494:pharmacology; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D006168:Guinea Pigs; D006977:Hypertension, Renal / Q000517:prevention & control; D007082:Ileum / Q000187:drug effects; D066298:In Vitro Techniques; D008297:Male; D009119:Muscle Contraction / Q000187:drug effects; D051381:Rats; D012083:Renin / Q000097:blood; D013329:Structure-Activity Relationship; D013997:Time Factors
chemical_list: D000804:Angiotensin II; D012083:Renin