Effects of local corticosteroids in skin infections.
Glucocorticoids exert valuable therapeutic activities in skin infections, although their use is limited by the occurrence of undesiderable effects: glucocorticoids depress the local defense mechanisms and in low concentrations, stimulate microbiol metabolism. For these reasons, combined preparations containing an antimicrobiol substance besides the glucocorticoid are recommended. However, interactions between the steroids and the antimicrobiols must be ruled out beforehand, i.e. the unimpaired activity of both steroid and antimicrobial must be assured. Examples of such investigations are reported for the most widely used compounds for topical therapy. The simultaneous use of a glucocorticoid and an antimicrobial is not recommended in only a few instances.
D000287:Administration, Topical; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D000893:Anti-Inflammatory Agents / Q000494:pharmacology / Q000627:therapeutic use*; D001419:Bacteria / Q000187:drug effects; D004336:Drug Antagonism; D004338:Drug Combinations; D004341:Drug Evaluation; D004347:Drug Interactions; D004352:Drug Resistance, Microbial; D004357:Drug Synergism; D005658:Fungi / Q000187:drug effects; D005938:Glucocorticoids; D006801:Humans; D012874:Skin Diseases, Infectious / Q000188:drug therapy*; D014780:Viruses / Q000187:drug effects
D000900:Anti-Bacterial Agents; D000893:Anti-Inflammatory Agents; D004338:Drug Combinations; D005938:Glucocorticoids