Ruptured appendicitis in children: continuing controversy over antibiotic combinations.
A prospective study has been made of 36 children with ruptured appendicitis. Alternate patients were managed with a standard protocol of therapy differing only in the antibiotics used. One group received a combination of penicillin/streptomycin/sulfadiazine while the other children were treated with cephalothin (Keflin) and cephalexin (Keflex). No major infections complications occurred in the P/S/S study group but there were four in the C/C patients. No serious adverse reactions due to the antibiotics occurred in either group.
D000293:Adolescent; D000367:Age Factors; D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D001064:Appendicitis / Q000150:complications / Q000188:drug therapy; D002512:Cephalothin / Q000627:therapeutic use; D002648:Child; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D007416:Intestinal Perforation / Q000188:drug therapy* / Q000209:etiology; D008297:Male
D000900:Anti-Bacterial Agents; D002512:Cephalothin