Repair excision of alkylated bases from DNA in vivo.
Recent experiments are reviewed which indicate that O6-alkylation of guanine in nuclear DNA constitutes a promutagenic lesion possibly implicated in malignant transformation by monofunctional alkylating carcinogens. The differential capacity of various organs to enzymically excise O6-alkylguanine from their DNA seems to correlate with the organ specificity of the carcinogenic effect.
D000477:Alkylating Agents / Q000494:pharmacology; D000818:Animals; D001921:Brain / Q000187:drug effects / Q000201:enzymology; D002273:Carcinogens; D004260:DNA Repair; D006147:Guanine / Q000378:metabolism*; D007668:Kidney / Q000187:drug effects / Q000201:enzymology; D008099:Liver / Q000187:drug effects / Q000201:enzymology; D008770:Methylnitrosourea; D009374:Neoplasms, Experimental / Q000139:chemically induced; D009602:Nitrosamines; D051381:Rats
D000477:Alkylating Agents; D002273:Carcinogens; D009602:Nitrosamines; D006147:Guanine; D008770:Methylnitrosourea