Tumor promoting constituent of Euphorbia serrata L. latex.
Euphorbia serrata latex has initially ingenol-3-palmitate, which by action of silica gel is converted to ingenol-20-palmitate. The former is responsible for the irritant and cocarcinogenic activity of the latex on mouse ear and on mice back skin.
D000818:Animals; D001415:Back; D002273:Carcinogens; D002850:Chromatography, Gel; D004224:Diterpenes / Q000633:toxicity*; D004305:Dose-Response Relationship, Drug; D004423:Ear; D005260:Female; D007509:Irritants; D008297:Male; D051379:Mice; D010169:Palmitic Acids / Q000633:toxicity; D010947:Plants, Toxic / Q000032:analysis*; D012408:Rubber / Q000633:toxicity*; D012878:Skin Neoplasms / Q000139:chemically induced
D002273:Carcinogens; D004224:Diterpenes; D007509:Irritants; D010169:Palmitic Acids; D012408:Rubber