Alteration of cholesterol synthesis in rat liver as induced by 4-methyl-5-hydroxy valeric acid.
The rate of cholesterogenesis in rat liver, measured by the incorporation of labelled acetate or mevalonate into cholesterol, was significantly supressed by the use of 4-methyl-5-hydroxy valeric acid sodium salt. This effect cannot be explained by changes in HMG CoA reductase activity.
D000085:Acetates / Q000378:metabolism; D000818:Animals; D002784:Cholesterol / Q000096:biosynthesis* / Q000097:blood; D002791:Cholesterol, Dietary; D004305:Dose-Response Relationship, Drug; D006880:Hydroxy Acids / Q000494:pharmacology*; D006903:Hydroxymethylglutaryl CoA Reductases / Q000378:metabolism; D008099:Liver / Q000187:drug effects / Q000378:metabolism*; D008297:Male; D008798:Mevalonic Acid / Q000378:metabolism; D008862:Microsomes, Liver / Q000201:enzymology; D051381:Rats; D013150:Spirostans / Q000494:pharmacology
D000085:Acetates; D002791:Cholesterol, Dietary; D006880:Hydroxy Acids; D013150:Spirostans; D002784:Cholesterol; D006903:Hydroxymethylglutaryl CoA Reductases; D008798:Mevalonic Acid