The effect of phenobarbital on patients with Dubin-Johnson syndrome.
11 patients with jaundice of Dubin-Johnson type were treated for 2 weeks with phenobarbital. Serum bilirubin diminished and hepatic clearance of sulfobromophthalein was variably enhanced; other measures of hepatic function were not significantly changed during therapy.
D000293:Adolescent; D000328:Adult; D001663:Bilirubin / Q000097:blood; D004341:Drug Evaluation; D005260:Female; D006801:Humans; D007566:Jaundice, Chronic Idiopathic / Q000097:blood / Q000188:drug therapy* / Q000503:physiopathology; D008099:Liver / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D010634:Phenobarbital / Q000627:therapeutic use*; D013448:Sulfobromophthalein
D013448:Sulfobromophthalein; D001663:Bilirubin; D010634:Phenobarbital