[Effect of striatectomy on the course of corazole seizures in rats].
Behaviouristic and EEG-manifestations of pentylentetrazol convulsions were studied in unrestrained rats with preliminarily destroyed striatum. The operation caused no significant disturbance of the appearance of the spike-wave activity, but sharply inhibited provocation of myoclonic and their change into tonico-clonic convulsions. Besides, there was an increase in the threshold, the duration and the severity of the attack; an epileptic status was even observed in 50% of these rats. Striatectomy eliminated the action of catecholaminergic agents (apomorphine, DOPA, haloperidol, chlorpromazine) on the thresholds of myclonic jerks and the attack.
D000818:Animals; D001058:Apomorphine / Q000627:therapeutic use; D002746:Chlorpromazine / Q000627:therapeutic use; D003342:Corpus Striatum / Q000601:surgery*; D004569:Electroencephalography; D005260:Female; D006220:Haloperidol / Q000627:therapeutic use; D007980:Levodopa / Q000627:therapeutic use; D008297:Male; D009207:Myoclonus / Q000601:surgery; D010433:Pentylenetetrazole; D051381:Rats; D012640:Seizures / Q000139:chemically induced / Q000175:diagnosis / Q000188:drug therapy / Q000601:surgery*
D007980:Levodopa; D006220:Haloperidol; D001058:Apomorphine; D002746:Chlorpromazine; D010433:Pentylenetetrazole
Vliianie striatéktomii na techenie korazolovykh sudorog u krys