Prevention of stress ulcer by somatostatin in rats.
In animal experiments it was examined, to what extent prophylactic application of Somatostatin is able to prevent the stress-induced ulcer of the rat. 32 male Wistar rats were exposed to a combined immobilisation-hypoxia-stress. Somatostatin was given intraperitoneally as bolus and intravenously as a continuous infusion. The results indicated that Somatostatin lowers significantly the incidence rate of stress-induced gastric ulcers in the rat.
D000818:Animals; D000860:Hypoxia / Q000150:complications; D008297:Male; D010437:Peptic Ulcer / Q000209:etiology / Q000517:prevention & control*; D051381:Rats; D013004:Somatostatin / Q000008:administration & dosage*; D013312:Stress, Physiological / Q000150:complications*
D013004:Somatostatin