Antibacterial activity of marine violet-pigmented Alteromonas with special reference to the production of brominated compounds.
The synthesis of several types of antibiotics was investigated in four strains of violet-pigmented bacteria belonging to the species Alteromonas luteo-violaceus. Two of the strains simultaneously produce an antibiotic polyanionic polysaccharide, weakly bound to the cells and diffusing throughout the medium, and two intracellular brominated bactericidal substances. The third strain only synthesizes the polyanionic antibiotic. The fourth one is totally inactive. The macromolecular antibiotic, probably responsible for the autointoxication of the bacteria in their cultures, acts at the respiratory level; it induces an increase of oxygen uptake and the production of peroxides by test bacteria. Thus, its activity is inhibited by catalase and peroxidase.
D000900:Anti-Bacterial Agents / Q000032:analysis / Q000096:biosynthesis* / Q000494:pharmacology; D001419:Bacteria / Q000032:analysis / Q000187:drug effects / Q000378:metabolism*; D001966:Bromine / Q000032:analysis / Q000378:metabolism*; D002861:Chromobacterium / Q000378:metabolism; D006861:Hydrogen Peroxide / Q000378:metabolism; D010101:Oxygen Consumption / Q000187:drug effects; D012623:Seawater; D013045:Species Specificity; D013210:Staphylococcus / Q000187:drug effects / Q000378:metabolism; D014871:Water Microbiology
D000900:Anti-Bacterial Agents; D006861:Hydrogen Peroxide; D001966:Bromine