Induction of rat hepatic mixed function monooxygenases by levamisole.
The effects of levamisole administration (20 mg/kg, i.p. daily for 10 days) on various parameters of hepatic microsomal metabolism in the famale rat were examined. Levamisole pretreatment resulted in significant increases over control values in the metabolism of aminopyrine and aniline in vitro, and in microsomal content of cytochrome P-450 and cytochrome b5.
D000632:Aminopyrine / Q000378:metabolism; D000814:Aniline Compounds / Q000378:metabolism; D000818:Animals; D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism; D003580:Cytochromes / Q000378:metabolism; D004790:Enzyme Induction / Q000187:drug effects; D005260:Female; D066298:In Vitro Techniques; D007978:Levamisole / Q000494:pharmacology*; D008099:Liver / Q000201:enzymology*; D006899:Mixed Function Oxygenases / Q000378:metabolism*; D010088:Oxidoreductases / Q000378:metabolism*; D051381:Rats
D000814:Aniline Compounds; D003580:Cytochromes; D000632:Aminopyrine; D007978:Levamisole; D003577:Cytochrome P-450 Enzyme System; D006899:Mixed Function Oxygenases; D010088:Oxidoreductases