Synthesis of eel-calcitonin and (asu1,7)-eel-calcitonin: contribution of the disulfide bond to the hormonal activity.
Eel-calcitonin and its [asu1,7]-analog, deamino-dicarba-analog, were synthesized by the conventional solution method. The natural-type product showed 4300 MRC U/mg in the hypocalcemic potency which was comparable to that of the natural hormone isolated from eel. Hormonal activity of the Asu-analog was also as high as 3400 MRC U/mg.
D000818:Animals; D002116:Calcitonin / Q000031:analogs & derivatives* / Q000138:chemical synthesis* / Q000502:physiology; D004220:Disulfides / Q000502:physiology; D004524:Eels
D004220:Disulfides; D002116:Calcitonin