A man with presumptive Y/Y translocation, observed in a forensic psychiatric department.
A man charged with a sexual offence was found to have complex karyotype anomaly, including a Y-chromosome of aberrant structure. Other features were: very small stature, skeletal deformities and obscure neurological defects. There were no gross psychiatric symptoms, nor was there mental retardation. Q- and G-banding and photometric scanning of the chromosomes of the propositus and his three healthy brothers indicated that the aberrant Y-chromosome probably arose from a reciprocal translocation, which may be written: t(Y: Y) (qter leads to p11: : q11 leads to qter). Fibroblast cultures differed from the lymphocytes: in the former the majority of the cells lacked the abnormal Y-chromosome, their karyotype being 45,X0.
D000015:Abnormalities, Multiple / Q000235:genetics; D000368:Aged; D002869:Chromosome Aberrations; D004392:Dwarfism / Q000235:genetics; D005347:Fibroblasts / Q000648:ultrastructure; D006801:Humans; D008214:Lymphocytes / Q000648:ultrastructure; D008297:Male; D012730:Sex Chromosomes; D012742:Sex Offenses; D014178:Translocation, Genetic