[Rat jejunal xylose and galactose absorption dependent on the intestinal bacterial flora and after cytostatics administration].
The influence of the bacterial flora of the intestine and of cytostatic drugs on the intestinal xylose and glucose absorption in the rat is studied by a perfusion technique in vivo. Conventional, germfree and decontaminated animals show no different xylose absorption rates while the galactose absorption is decreased in germfree and decontaminated animals compared to conventional rats. Three days after a single injection of cytostatic drugs the xylose absorption is diminished in conventional and decontaminated animals compared to untreated rats. In germfree rats no effect of cytostatics on the xylose absorption can be proved. The galactose absorption is unchanged after cytostatics in conventional and decontaminated animals, but increased in germfree rats.
D000818:Animals; D000900:Anti-Bacterial Agents / Q000494:pharmacology; D000970:Antineoplastic Agents / Q000494:pharmacology*; D003630:Daunorubicin / Q000494:pharmacology; D004755:Enterobacteriaceae / Q000302:isolation & purification; D005690:Galactose; D005856:Germ-Free Life; D007408:Intestinal Absorption / Q000187:drug effects; D007422:Intestines / Q000382:microbiology*; D011241:Prednisone / Q000494:pharmacology; D051381:Rats; D014750:Vincristine / Q000494:pharmacology; D014994:Xylose
D000900:Anti-Bacterial Agents; D000970:Antineoplastic Agents; D014750:Vincristine; D014994:Xylose; D011241:Prednisone; D005690:Galactose; D003630:Daunorubicin
Jejunale Xylose- und Galaktoseabsorption der Ratte in Abhängigkeit von der bakteriellen Darmflora und nach Zytostatikagabe