title: [Elimination of toxic peptides from amanita phalloides by charcoal perfusion in vitro (author's transl)].
abstract: Charcoal perfusion in vitro resulted in virtually complete detoxication of an extract from 170 g of Amanita phalloides in aqueous or plasma protein solution. After 4 min of perfusion the amanitin content was reduced to 1-2% after 15 min it was less than 1% of the starting material. Under the same conditions toadstool toxin was eliminated from plasma protein solution too: after 4 min of perfusion a dose of remaining material, corresponding to the LD70 of the starting material, was nontoxic in mice.
mesh_terms: D000546:Amanitins / Q000633:toxicity*; D001798:Blood Proteins; D002606:Charcoal; D010477:Perfusion; D013997:Time Factors
chemical_list: D000546:Amanitins; D001798:Blood Proteins; D002606:Charcoal
vernacular_title: Elimination von Knollenblätterpilzgift (Amanitine) durch Kohle-Perfusion in vitro