Genetic composition of a high-yielding influenza A virus recombinant: a vaccine strain against "Swine" influenza.
Analysis of the RNA migration pattern of a high-yielding influenza virus recombinant, X-53, used in vaccine production, reveals that only the two genes coding for hemagglutinin and neuraminidase antigens were derived from the "swine" influenza virus parent. A/New Jersey/11/76, while six were acquired from the A/PR/8/34 (HON1) parent, donor of the high yield characteristic.
D000956:Antigens, Viral / Q000032:analysis; D005796:Genes; D006389:Hemagglutinins, Viral / Q000032:analysis; D006824:Hybridization, Genetic; D009980:Influenza A virus / Q000032:analysis* / Q000276:immunology; D009439:Neuraminidase / Q000276:immunology / Q000378:metabolism; D009975:Orthomyxoviridae / Q000032:analysis*; D012367:RNA, Viral / Q000032:analysis*; D014764:Viral Proteins / Q000378:metabolism; D014776:Virus Cultivation
D000956:Antigens, Viral; D006389:Hemagglutinins, Viral; D012367:RNA, Viral; D014764:Viral Proteins; D009439:Neuraminidase