[Comparative activity of ethaverine and papaverine on chronotropic and dromotropic cardiac functions in the anesthetized dog].
Ethaverine inhibits both atrioventricular conduction and heart rate, starting at a dosage of 1 mg/kg, injected i.v. into the anaesthetized dog. In the experimental conditions used, ethaverine is clearly different from papaverine, which stimulates both at a dosage between 1 and 10 mg/kg, and which only produces an inhibitory effect starting at a dosage of 20 mg/kg, with the appearance of cardiotoxic phenomena. After total cardiac denervation the inhibitory action of ethaverine persists partially, especially at the atrioventricular level, which is probably due to a direct effect on the heart muscle. The observed differences can hardly be explained by a more pronounced cardiac toxicity. Consequently, the ethyl-derivative of papaverine constitutes, in certain aspects, a molecule with original pharmacological properties.
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D004285:Dogs; D005260:Female; D006329:Heart Conduction System / Q000187:drug effects*; D006339:Heart Rate / Q000187:drug effects*; D008297:Male; D010208:Papaverine / Q000031:analogs & derivatives* / Q000494:pharmacology*; D013997:Time Factors; D014628:Vagotomy
C007639:ethaverine; D010208:Papaverine
Activit comparée de l'ethavérine et de la papavérine sur les fonctions cardiaques chronotrope et dromotrope chez le chien anesthésié