title: Deficiency in renomedullary prostaglandin synthesis related to the evolution of essential hypertension.
abstract: Continued PG synthesis in the early stages of essential hypertension might reflect an activation of the renal antihypertensive function in respect to neurogenic and/or hormonal pression stimuli, subsequently a deficiency of renal PG synthesis related to irreversible changes with the kidney would lead to the prepoderance of a pressure mechanism, resulting to a further increase of blood pressure.
mesh_terms: D000328:Adult; D005260:Female; D006801:Humans; D006973:Hypertension / Q000209:etiology / Q000652:urine*; D007679:Kidney Medulla / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D011453:Prostaglandins / Q000096:biosynthesis / Q000652:urine*; D011458:Prostaglandins E / Q000652:urine; D011460:Prostaglandins F / Q000652:urine
chemical_list: D011453:Prostaglandins; D011458:Prostaglandins E; D011460:Prostaglandins F