Activation of neurons in the cerebellar nuclei and ascending reticular formation by stimulation of the cerebellar surface.
Electrical stimulation of the cerebellar surface has been used therapeutically for the control of certain epileptic seizure and motor disorders. Recent hypotheses suggest that the therapeutic results in the treatment of epilepsy might be a consequence of the activation of Purkinje cells which subsequently inhibit the epileptic activity in the cerebrocellular loop. These experiments establish that an anatomical substrate exists whereby the effects of stimulating the cerebellar surface might be mediated by the ascending reticular formation and the non-specific thalamic nuclei. Specifically, the stimulation of the cerebellar surface activates not only Purkinje cells but also cerebellar afferent systems, climbing fibers and mossy fibers, and neurons in the cerebellar nuclei and reticular formation. In addition, recordings from neurons in the ascending reticular formation suggest that stimulation of the cerebellar surface can affect processing of ascending sensory information, thus influencing neural integration of non-specific sensory system.
D000344:Afferent Pathways / Q000502:physiology*; D000818:Animals; D002415:Cats; D002525:Cerebellar Cortex / Q000502:physiology*; D002529:Cerebellar Nuclei / Q000166:cytology / Q000502:physiology*; D004558:Electric Stimulation; D005071:Evoked Potentials; D009474:Neurons / Q000502:physiology; D009847:Olivary Nucleus / Q000502:physiology; D011689:Purkinje Cells / Q000502:physiology; D011930:Reaction Time; D012154:Reticular Formation / Q000166:cytology / Q000502:physiology*