Effect of isoproterenol on urinary function in goats.
Intraventricular administration of small doses (6.3-19-58 ng/kg/min) of isoproterenol (ISO) in non-hydrated goats produced a diuretic response, a decrease in urinary Na+, K+ and Cl- excretion and an increase in free water clearance. The diuretic response of ISO could be blocked by propranolol, but not by phentolamine. The data suggest that hypothalamic beta-adrenoceptors are involved in the inhibition of ADH release.
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D004231:Diuresis / Q000187:drug effects*; D005260:Female; D006041:Goats; D007276:Injections, Intraventricular; D007545:Isoproterenol / Q000008:administration & dosage / Q000494:pharmacology*; D011433:Propranolol / Q000494:pharmacology; D013997:Time Factors; D014882:Water-Electrolyte Balance / Q000187:drug effects
D011433:Propranolol; D007545:Isoproterenol