[Absorption, distribution and the duration of retention of neomycin in the body of pregnant rabbits and their fetuses].
Neomycin was administered intramuscularly to rabbits in single doses of 50000 gamma/kg 24--25-day gravid rabbits were sacrificed 1.5-2-3-4-6-12-24 hours and 2-3-6 days after the drug administration. 3--4 rabbits were used in every experiment. The antibiotic concentration was determined with the agar-diffusion method. It was found that the drug was present in various bactericidal concentrations in all 55 organs, tissues and fluids of the rabbits and the fetus examined except the crystalline lens in the rabbits and the brain, liver and bile cyst of the fetus. In some material of the rabbits and their fetus, high levels of neomycin were detected during 6 days, i. e. up to the end of the experiment. The highest neomycin levels in the organs, tissues and fluids of the fetus were detected somewhat later than in those of the rabbits. However, their retention time was longer. It is necessary to forbear from using antibiotics, such as neomycin, monomycin and others, which retained for long periods of time in the organism.
D000042:Absorption; D000818:Animals; D001702:Biopharmaceutics; D005260:Female; D005333:Fetus / Q000032:analysis / Q000378:metabolism*; D008431:Maternal-Fetal Exchange / Q000187:drug effects; D009355:Neomycin / Q000032:analysis / Q000378:metabolism*; D011247:Pregnancy; D011817:Rabbits; D013997:Time Factors
D009355:Neomycin
Vsasyvanie, raspredelenie i prodolzhitel'nost' sokhraneniia neomitsina v organizme beremennykh krol'chikh i ikh plodov