Interaction of aflatoxin B1 with some biologically important substances.
The interaction of aflatoxin B1 with a number of biologically important substances has been investigated by spectrophotometric and fluorimetric techniques. The ultra-violet absorption of tryptophan, adenosine, RNA and DNA were altered by the addition of aflatoxin B1. Some amino-acids, purine and pyrimidine derivatives, bovine-serum albumin and DNA quenched the fluorescence of aflatoxin B1. Fluorescence polarization data suggested that the interaction of aflatoxin B1 with bovine-serum albumin was stronger than that with DNA.
D000241:Adenosine / Q000494:pharmacology; D000348:Aflatoxins / Q000378:metabolism / Q000494:pharmacology*; D004247:DNA / Q000494:pharmacology; D004347:Drug Interactions; D005453:Fluorescence; D012313:RNA / Q000494:pharmacology; D014364:Tryptophan / Q000494:pharmacology
D000348:Aflatoxins; D012313:RNA; D014364:Tryptophan; D004247:DNA; D000241:Adenosine