Urothelial hyperplasia of the renal papillae in female Sprague-Dawley rats induced by long term feeding of phenacetin.
Twenty-one of 40 rats fed phenacetin in the diet for up to 86 weeks developed urothelial hyperplasia of the renal papillae. Two of 30 rats in the control group had similar changes associated with chronic pyelitis. The difference is statistically significant (p less than 0.01).
D000818:Animals; D002908:Chronic Disease; D005260:Female; D006965:Hyperplasia; D007680:Kidney Neoplasms / Q000139:chemically induced / Q000473:pathology; D007682:Kidney Pelvis / Q000187:drug effects / Q000473:pathology*; D010615:Phenacetin / Q000008:administration & dosage / Q000633:toxicity*; D011702:Pyelitis / Q000139:chemically induced; D051381:Rats
D010615:Phenacetin