title: [Effect of nerobol on the water-electrolyte balance and kidney function in man during 120-day hypokinesia].
abstract: The influence of anabolic steroids on the fluid-electrolyte metabolism and renal function of man was studied during a prolonged bed rest experiment. Seven test subjects were kept under surveillance. Three test subjects were given nerobol and four subjects served as controls. The fluid-electrolyte metabolism and the osmoregulatory function of the kidneys were studied. Nerobol induced a decreased excretion of sodium, potassium, calcium, chlorides and osmotically active substances. Nerobol produced the most pronounced effect on the calcium and potassium metabolism. The effect of the drug used during the prolonged bed rest experiment depended on the time and dosage as well as on the state of fluid-eletrolyte metabolism and the renal function.
mesh_terms: D000328:Adult; D045930:Anabolic Agents / Q000494:pharmacology*; D002118:Calcium / Q000652:urine; D004231:Diuresis / Q000187:drug effects; D005919:Glomerular Filtration Rate / Q000187:drug effects; D006801:Humans; D007103:Immobilization; D007668:Kidney / Q000187:drug effects / Q000502:physiology*; D008297:Male; D009318:Natriuresis / Q000187:drug effects; D011188:Potassium / Q000652:urine; D013997:Time Factors; D014882:Water-Electrolyte Balance / Q000187:drug effects*
chemical_list: D045930:Anabolic Agents; D011188:Potassium; D002118:Calcium
vernacular_title: Vliianie nerobola na vodno-solevoĭ obmen i funktsiiu pochek cheloveka pri 120-sutochnoĭ gipokinezii