3-hydroxy-3-methylglutaric acid and experimental atherosclerosis in rats.
In rats 3-hydroxy-3-methylglutaric acid effectively counteracts the lipemic and atherosclerotic response of massive doses of vitamin D2. It regressed the formation of atheromatous arterial lesions. Furthermore the significant decrease in serum beta-lipoprotein levels on HMG treatment could be due to decrease in VLDL triglyceride and cholesterol levels.
D000818:Animals; D001161:Arteriosclerosis / Q000097:blood / Q000378:metabolism / Q000517:prevention & control*; D002784:Cholesterol / Q000378:metabolism; D004036:Diet, Atherogenic; D005971:Glutamates / Q000627:therapeutic use*; D008297:Male; D010743:Phospholipids / Q000378:metabolism; D051381:Rats; D014280:Triglycerides / Q000378:metabolism
D005971:Glutamates; D010743:Phospholipids; D014280:Triglycerides; D002784:Cholesterol