The effects of anti-rheumatoid drugs on the in vitro activity of human serum hyaluronidase.
Fourteen antirheumatoid drugs were tested for their effects on the in vitro hyaluronidase activity of normal human serum. Four drugs produced significant changes in enzyme activity. Different results were obtained with ovine testicular hyaluronidase when diluted with either saline or inactivated human serum. No increase in serum hyaluronidase activity was found in patients with rheumatoid arthritis. There was no evidence for the existence of tissue specific isoenzymes of hyaluronidase in the serum of either normal subjects or patients with rheumatoid arthritis.
D000700:Analgesics / Q000494:pharmacology* / Q000627:therapeutic use; D000893:Anti-Inflammatory Agents / Q000494:pharmacology* / Q000627:therapeutic use; D001172:Arthritis, Rheumatoid / Q000188:drug therapy*; D004588:Electrophoresis, Cellulose Acetate; D005260:Female; D006801:Humans; D006821:Hyaluronoglucosaminidase / Q000097:blood*; D008297:Male; D013050:Spectrometry, Fluorescence
D000700:Analgesics; D000893:Anti-Inflammatory Agents; D006821:Hyaluronoglucosaminidase