The binding of chloramphenicol to serum proteins in patients with chronic renal insufficiency.
The binding (r) of chloramphenicol to serum proteins is significantly lower in patients with chronic renal failure than in normal subjects. Before hemodialysis, the mean r value in patients with chronic renal insufficiency was 0.165 mg/g (+/-0.003) versus 0.188 mg/g (+/-0.004) in healthy individuals. Hemodialysis produced a significant rise in r (to 0.182 mg/g, +/-0.004). Decrease in the serum concentration of albumin in patients with chronic renal insufficiency does not seem to be the sole factor responsible for decreased r.
D000328:Adult; D001798:Blood Proteins / Q000378:metabolism*; D001806:Blood Urea Nitrogen; D002701:Chloramphenicol / Q000097:blood*; D003404:Creatinine / Q000097:blood; D005921:Glomerulonephritis / Q000097:blood; D006801:Humans; D007676:Kidney Failure, Chronic / Q000097:blood*; D008875:Middle Aged; D007690:Polycystic Kidney Diseases / Q000097:blood; D011485:Protein Binding; D011704:Pyelonephritis / Q000097:blood; D006435:Renal Dialysis
D001798:Blood Proteins; D002701:Chloramphenicol; D003404:Creatinine