[Morphologic changes in the urinary bladder of mice induced by metabolites of tryptophan and tyrosine].
45-day-old 229 mice of lines C57Bl and CC57Br were injected subcutaneously water solutions of tryptophan and thyrosine metabolites 2.5 mg twice a week, the total dosage being 45-50 mg per mouse. For the control mice of the same line were taken. Within the period from 3.5 to 19 months following injection of the metabolites in the urinary bladder of animals, there were observed focal proliferates of the epithelium not infrequently with its atypism, and also lymphoid infiltration of submucous and muscle layers, reticulosarcomas, papillomas, precancerous conditions and cancer. The question of the importance of endogenous blastomogenic substances in the development of "spontaneous" tumors of the urinary bladder in man is discussed.
D015095:3-Hydroxyanthranilic Acid / Q000633:toxicity; D000098:Acetophenones / Q000633:toxicity; D000179:Acrylates / Q000633:toxicity; D000818:Animals; D002273:Carcinogens; D007211:Indoles / Q000633:toxicity; D007773:Lactates / Q000633:toxicity; D051379:Mice; D008810:Mice, Inbred C57BL; D008815:Mice, Inbred Strains; D009374:Neoplasms, Experimental; D010212:Papilloma / Q000139:chemically induced; D010636:Phenols / Q000633:toxicity; D010667:Phenylpyruvic Acids / Q000633:toxicity; D011230:Precancerous Conditions / Q000139:chemically induced; D014364:Tryptophan / Q000031:analogs & derivatives* / Q000633:toxicity; D014443:Tyrosine / Q000031:analogs & derivatives* / Q000633:toxicity; D001749:Urinary Bladder Neoplasms / Q000139:chemically induced*
D000098:Acetophenones; D000179:Acrylates; D002273:Carcinogens; D007211:Indoles; D007773:Lactates; D010636:Phenols; D010667:Phenylpyruvic Acids; D015095:3-Hydroxyanthranilic Acid; D014443:Tyrosine; D014364:Tryptophan
Morfologicheskie izmeneniia mochevogo puzyria u mysheĭ, vyzvannye metabolitami triptofana i tirozina