[Echocardiographic evaluation of left ventricular function during therapy with cardiovascularly effective drugs].
The task of this study was to examine the feasibility of applying echocardiography in determining alterations of left ventricular performance during administration of vasoactive drugs. Patients suffering from congestive heart failure were treated with Digitalis, other patients with normal hearts were subjected to infusion therapy of Isoproterenol, Propranolol, Verapamil and Calcium chloride. A new concept for interpretation of function curves relating the velocity of circumferential fiber shortening (VCF) and time was introduced to establish the inotropic, bathmotropic and chronotropic effects of vasoactive drugs to the myocardium. It can be concluded that echocardiography is a feasible tool in determining changes of left ventricular dynamics during administration of vasoactive drugs, in indicating the individual dosage of a vasoactive drug in each patient and the follow-up the course of the therapeutic success.
D004077:Digoxin / Q000031:analogs & derivatives / Q000494:pharmacology; D004452:Echocardiography; D006321:Heart / Q000187:drug effects; D006333:Heart Failure / Q000503:physiopathology; D006352:Heart Ventricles / Q000503:physiopathology*; D006801:Humans; D007545:Isoproterenol / Q000494:pharmacology; D011433:Propranolol / Q000494:pharmacology; D011442:Proscillaridin / Q000494:pharmacology; D014700:Verapamil / Q000494:pharmacology
D004077:Digoxin; D011433:Propranolol; D014700:Verapamil; D011442:Proscillaridin; D007545:Isoproterenol
Neue Gesichtspunkte in der echokardiographischen Beurteilung der linksventrikulären Funktion unter Therapie mit herz-kreislauf-wirksamen Pharmaka