Hemodynamic drug interaction: peridural lidocaine and intravenous ephedrine.
Hypotension following peridural anesthesia with lidocaine was treated by intravenous injection of ephedrine. The ephedrine relieved the cardiovascular depression, but was associated with a concomitant increase in plasma lidocaine concentrations. This increase may push the plasma lidocaine concentration into the toxic region.
D000328:Adult; D000767:Anesthesia, Epidural; D001794:Blood Pressure / Q000187:drug effects*; D002302:Cardiac Output / Q000187:drug effects; D004357:Drug Synergism; D004809:Ephedrine / Q000627:therapeutic use*; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D008012:Lidocaine / Q000009:adverse effects* / Q000097:blood / Q000494:pharmacology; D008297:Male
D008012:Lidocaine; D004809:Ephedrine