Effects of manganese on substrate oxidation and oxidative phoshorylation in rat liver mitochondria.
In vitro Mn2+ decreases respiration at metabolic state III and at the uncoupled state. Pretreatment with Mn2+ decreased also ADP to oxygen ratio in rat liver and brain mitochondria. The mechanism of manganese toxicity involving suppression of substrate oxidation and decrease of oxidative phosphorylation efficiency in brain mitochondria is discussed.
D000818:Animals; D001921:Brain / Q000648:ultrastructure*; D002118:Calcium / Q000494:pharmacology; D066298:In Vitro Techniques; D008345:Manganese / Q000494:pharmacology*; D008928:Mitochondria / Q000187:drug effects / Q000378:metabolism*; D008930:Mitochondria, Liver / Q000187:drug effects / Q000378:metabolism*; D010084:Oxidation-Reduction; D010085:Oxidative Phosphorylation / Q000187:drug effects*; D010101:Oxygen Consumption / Q000187:drug effects; D051381:Rats; D013386:Succinates / Q000378:metabolism
D013386:Succinates; D008345:Manganese; D002118:Calcium