A dopaminergic mechanism in mania.
The authors present a case study that explores the relationship of dopamine function and manic illness through the use of two drugs with relatively specific effects in stimulating and blocking dopamine receptors--piribedil (ET--495) and pimozide, respectively. Piribedil, as well as d-amphetamine, was associated with manic episodes, while pimozide had an antimanic effect. These observations suggest that dopaminergic mechanisms may be involved in the mediation of manic episodes in at least some patients.
D001714:Bipolar Disorder / Q000188:drug therapy / Q000378:metabolism*; D003863:Depression / Q000188:drug therapy; D004298:Dopamine / Q000378:metabolism*; D006719:Homovanillic Acid / Q000134:cerebrospinal fluid; D006801:Humans; D006897:Hydroxyindoleacetic Acid / Q000134:cerebrospinal fluid; D008094:Lithium / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged; D010868:Pimozide / Q000494:pharmacology; D010891:Piribedil / Q000494:pharmacology; D011569:Psychiatric Status Rating Scales; D014268:Trifluoperazine / Q000627:therapeutic use
D010868:Pimozide; D014268:Trifluoperazine; D006897:Hydroxyindoleacetic Acid; D008094:Lithium; D010891:Piribedil; D004298:Dopamine; D006719:Homovanillic Acid