[Effect of total gamma-irradiation on the rate of steroid hormone hydroxylation by rat liver microsomes].
gamma-irradiation in doses of over 600 r proved to decrease the rate of androgen hydroxylation significantly; the rate of hydroxylation of the estrogens under study altered but little. Under the mentioned irradiation conditions the content of cytochrome P-450 in rat hepatic microsomes diminished. A reduction of the hydroxylation rate of steroid hormones by rat hepatic microsomes under the effect of total gamma-irradiation apparently depended on the qualitative changes of cytochrome P-450.
D000818:Animals; D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism; D006728:Hormones / Q000378:metabolism*; D006900:Hydroxylation; D008297:Male; D008862:Microsomes, Liver / Q000378:metabolism*; D011830:Radiation Effects; D051381:Rats; D013256:Steroids / Q000378:metabolism*
D006728:Hormones; D013256:Steroids; D003577:Cytochrome P-450 Enzyme System
Vliianie obschchego gamma-oblucheniia na skorost' gidroksilirovaniia steroidnykh gormonov mikrosomami pecheni krys