[Influence of anthraquinones on the formation of urinary calculi in experimental animals (author's transl)].
The growth-inhibiting influence of hydroxy-anthraquinone derivatives of root of rubia in various calcium offerings was investigated using a foreign-body bladder calculus model in rabbits. Following oral doses of glycoside-bound and free aglycemics a pronounced calcium-complex binding effect and a significant reduction in the growth rate of the calculi was observed. Use of anthraquinone glycosides to prevent recurrence of calcium-containing urinary stones is recommended.
D000818:Animals; D000880:Anthraquinones / Q000627:therapeutic use*; D002118:Calcium / Q000378:metabolism; D004195:Disease Models, Animal; D005260:Female; D006027:Glycosides / Q000627:therapeutic use*; D010070:Oxalates / Q000378:metabolism; D010710:Phosphates / Q000378:metabolism; D011817:Rabbits; D013329:Structure-Activity Relationship; D001744:Urinary Bladder Calculi / Q000517:prevention & control*
D000880:Anthraquinones; D006027:Glycosides; D010070:Oxalates; D010710:Phosphates; D002118:Calcium
Einfluss von Anthrachinonderivaten auf die tierexperimentelle Harnsteinbildung