title: Pharmacology of procaine in the horse: a preliminary report.
abstract: Rapid intravenous injection of 1 g of procaine hydrochloride in Thoroughbred mares produced variable signs of central nervous system excitation for as long as 4 minutes. Plasma concentrations of procaine were similarly variable and transient, decreasing with a half-life of approximately 25 minutes. In vitro, plasma from freshly collected equine blood hydrolyzed procaine with a half-life of approximately 7.5 minutes. This hydrolysis was apparently due to plasma esterases. Penicillin, when added free or complexed as procaine-penicillin, did not protect procaine against hydrolysis by these plasma esterases at pH 7.4.
mesh_terms: D000818:Animals; D002490:Central Nervous System / Q000187:drug effects; D005260:Female; D006736:Horses / Q000097:blood*; D007273:Injections, Intramuscular; D007275:Injections, Intravenous; D010402:Penicillin G Procaine / Q000097:blood; D011343:Procaine / Q000008:administration & dosage / Q000097:blood / Q000494:pharmacology*
chemical_list: D010402:Penicillin G Procaine; D011343:Procaine