Thyroxine-induced activation of hypothalamo-hypophysial axis in neotenic salamander larvae.
Thyroxine injected into the hypothalamus of neotenic Ambystoma tigrinum induces metamorphosis by activating hypothalamo-hypophysial stimulatory control of thyroid activity, thereby removing the hypothalamic block to metamorphosis.
D000557:Ambystoma / Q000502:physiology*; D000818:Animals; D007031:Hypothalamus / Q000187:drug effects*; D007457:Iodine Radioisotopes / Q000378:metabolism; D007814:Larva; D008675:Metamorphosis, Biological / Q000187:drug effects*; D011388:Prolactin / Q000494:pharmacology; D013961:Thyroid Gland / Q000378:metabolism; D013974:Thyroxine / Q000494:pharmacology*
D007457:Iodine Radioisotopes; D011388:Prolactin; D013974:Thyroxine