Convulsive seizure induced by intracerebral injection of semicarbazide (an anti-vitamin B6) in the mouse.
The direct injection of semicarbazide (SC), an antivitamin B6 (anti-B6), into the lateral ventricle of the mouse brain induced convulsion and tremors at a smaller dose after a shorter latent period than that in systemic administration. The symptoms were prevented by pyridoxine, aminooxyacetic acid or acetone, while they enhanced by pyridoxal, pyridoxal phosphate, or some other anti-B6. In mice fed a vitamin B6 (B6)-deficient diet, convulsion and tremors occurred at smaller doses of SC than those in mice given control food, and were counteracted by pyridoxine. On the other hand, mice into which SC had been injected in the neighboring site of the lambda first showed running fits, which was followed by convulsion and tremors.
D000818:Animals; D000963:Antimetabolites / Q000008:administration & dosage; D004305:Dose-Response Relationship, Drug; D004357:Drug Synergism; D007276:Injections, Intraventricular; D008297:Male; D051379:Mice; D011736:Pyridoxine / Q000627:therapeutic use; D012640:Seizures / Q000139:chemically induced* / Q000188:drug therapy / Q000209:etiology; D012663:Semicarbazides / Q000008:administration & dosage; D014202:Tremor / Q000139:chemically induced* / Q000188:drug therapy / Q000209:etiology; D026681:Vitamin B 6 Deficiency / Q000150:complications
D000963:Antimetabolites; D012663:Semicarbazides; D011736:Pyridoxine