title: A prosthetic vas deferens.
abstract: Six dogs were implanted with the synthetic vas deferens device as part of our continuing research into the development of a reversible occlusive device for implant in the transected vas deferens. The experimental objectives were to assess the effects of sperm path length and duration of aspermia on total sperm count and motility by implanting three different lengths of the device in animals with different degrees of aspermic duration induced by bilateral vasectomy. Device lengths varied from 1.55 cm to 4.3 cm including the pilot tubes. The prosthesis is fabricated entirely of silicone rubber with Dacron velour tissue ingrowth material bonded to the outside surface of the ring to which vas ends are sutured. The pilot tubes extend 4 mm beyond the suture rings and are 0.6 mm OD with a 0.3 mm ID that extends through the entire length of the device. The flexible pilot tubes are an important feature of this design and insert into the vas lumen ensuring alignment between the device and the vas deferens while maintaining the necessary resiliency to adapt to the inherent movements of the vas without perforation. All animals included in these experiments were carefully selected and conditioned before implant. The evaluation of performance was based on semen samples collected at one week intervals. Sperm subsequently appeared in the ejaculate of all 6 dogs, demonstrating that the restoration of sperm transport can be restored after bilateral vasectomy through the implantation of a prosthetic vas deferens. The potential application of this device to the human male for the restoration of fertility appears excellent.
mesh_terms: D000818:Animals; D002516:Ceramics; D004285:Dogs; D008297:Male; D011140:Polyurethanes; D019736:Prostheses and Implants; D012826:Silicone Elastomers; D013075:Sperm Capacitation; D013081:Sperm Motility; D013083:Sperm Transport; D013193:Stainless Steel; D013243:Sterilization Reversal / Q000295:instrumentation*; D014649:Vas Deferens
chemical_list: D011140:Polyurethanes; D012826:Silicone Elastomers; D013193:Stainless Steel