title: The effect of isoprenaline on induction of tumours by methyl nitrosourea in the salivary and mammary glands of female wistar rats.
abstract: Pretreatment of rats with isoprenaline sulphate (IPR) stimulated DNA synthesis in both salivary and mammary gland tissues. Salivary gland tumours induced by N-methyl-N-nitrosourea (MNU) were observed for the first time in rats, but occurred only in IPR-pretreated animals given MNU during the period of IPR-stimulated DNA synthesis. The cumulative index of MNU-induced mammary tumours and the number of tumours per tumour-bearing rat were increased by IPR-pretreament only if the animals received MNU during the period of IPR-stimulated DNA synthesis.
mesh_terms: D000818:Animals; D004247:DNA / Q000096:biosynthesis; D005260:Female; D007545:Isoproterenol / Q000494:pharmacology*; D008321:Mammary Glands, Animal / Q000378:metabolism; D008325:Mammary Neoplasms, Experimental / Q000139:chemically induced*; D008770:Methylnitrosourea / Q000633:toxicity*; D009607:Nitrosourea Compounds / Q000633:toxicity*; D010307:Parotid Neoplasms / Q000139:chemically induced; D051381:Rats; D012468:Salivary Gland Neoplasms / Q000139:chemically induced*; D012469:Salivary Glands / Q000378:metabolism; D013268:Stimulation, Chemical; D013997:Time Factors
chemical_list: D009607:Nitrosourea Compounds; D008770:Methylnitrosourea; D004247:DNA; D007545:Isoproterenol