O-methylation and decarboxylation of alpha-methyldopa in brain and spinal cord: depletion of S-adenosylmethionine and accumulation of metabolites in catecholaminergic neurones.
D000818:Animals; D001921:Brain / Q000378:metabolism*; D002395:Catecholamines / Q000502:physiology*; D003653:Decarboxylation; D003864:Depression, Chemical; D006892:Hydroxydopamines / Q000008:administration & dosage / Q000494:pharmacology; D007276:Injections, Intraventricular; D008297:Male; D008745:Methylation; D008750:Methyldopa / Q000378:metabolism* / Q000494:pharmacology; D051379:Mice; D009474:Neurons / Q000378:metabolism*; D051381:Rats; D012436:S-Adenosylmethionine / Q000378:metabolism*; D013116:Spinal Cord / Q000378:metabolism*
D002395:Catecholamines; D006892:Hydroxydopamines; D008750:Methyldopa; D012436:S-Adenosylmethionine