Drug therapy for postragotomy gastric stasis.
An unusual but well-recognized complication of truncal vagotomy with a drainage procedure is severe gastric stasis (atony). In 6 patients presenting with this problem drug therapy was initiated after mechanical obstruction of the gastric outlet was excluded by radiology. Bethanechol chloride was successful in stimulating gastric peristalsis in all the patients, with consequent improvement of symptoms in 5 out of the 6 subjects. Metoclopramide alone was of no value in starting peristalsis but of pssible benefit once gastric motility had begun.
D000328:Adult; D000368:Aged; D001626:Bethanechol Compounds / Q000008:administration & dosage / Q000627:therapeutic use*; D004322:Drainage; D005260:Female; D005769:Gastrointestinal Motility / Q000187:drug effects*; D006801:Humans; D008297:Male; D008787:Metoclopramide / Q000008:administration & dosage / Q000627:therapeutic use*; D008875:Middle Aged; D013272:Stomach Diseases / Q000188:drug therapy* / Q000209:etiology; D014628:Vagotomy / Q000009:adverse effects*
D001626:Bethanechol Compounds; D008787:Metoclopramide