Effect of norepinephrine on gastric wound healing.
Lavage of the stomach with norepinephrine has been suggested as a temporary means of controlling upper gastrointestinal tract bleeding. The effect of norepinephrine on the healing of a standard gastric incision in the rat was studied using irrigation topically. When compared with those rats in the control study that were irrigated with a saline solution alone, no significant difference was found in the tensile strength, local inflammatory response or synthesis of new collagen, as determined by the hydroxyproline-proline ratio. There would appear to be no adverse effect on gastric wound healing as a result of preliminary irrigation of the gastric mucosa with norepinephrine given topically in a concentration of 16 milligrams per liter.
D000818:Animals; D003094:Collagen / Q000096:biosynthesis; D005260:Female; D005753:Gastric Mucosa / Q000378:metabolism; D008297:Male; D009638:Norepinephrine / Q000494:pharmacology*; D051381:Rats; D013270:Stomach / Q000293:injuries* / Q000473:pathology; D013718:Tensile Strength / Q000187:drug effects; D014945:Wound Healing / Q000187:drug effects*
D003094:Collagen; D009638:Norepinephrine