Long-term assessment of children exposed in utero to carbimazole.
Twenty-five children aged 3 to 13 years who had been exposed in utero to carbimazole were assessed physically and psychologically to evaluate the long-term effects of the drug on growth and development. 2 children had congenital malformations but all had normal pituitary-thyroid function and appeared to have grown and developed normally.
D000014:Abnormalities, Drug-Induced; D000293:Adolescent; D001824:Body Constitution; D002231:Carbimazole / Q000009:adverse effects* / Q000627:therapeutic use; D002386:Cataract / Q000209:etiology; D002648:Child; D002653:Child Behavior Disorders / Q000209:etiology; D002675:Child, Preschool; D005260:Female; D005333:Fetus / Q000187:drug effects*; D005500:Follow-Up Studies; D006801:Humans; D006980:Hyperthyroidism / Q000188:drug therapy; D007360:Intelligence; D017880:Limb Deformities, Congenital; D008297:Male; D008431:Maternal-Fetal Exchange; D010902:Pituitary Gland / Q000187:drug effects*; D011247:Pregnancy; D011248:Pregnancy Complications / Q000188:drug therapy*; D013960:Thyroid Function Tests; D013961:Thyroid Gland / Q000187:drug effects*
D002231:Carbimazole