title: Abnormal tissue distribution of lead in amyotrophic lateral sclerosis.
abstract: The lead content of cerebrospinal fluid (CSF) was found to be significantly elevated in 12 patients with amyotrophic lateral sclerosis, when compared to 28 control subjects having non-degenerative neurological disorders. The difference could not be explained as being merely secondary to blood-CSF barrier damage. A hypothetical model of the pathogenesis of the disease is advanced and the results are discussed in relation to this model.
mesh_terms: D000328:Adult; D000368:Aged; D000418:Albumins / Q000134:cerebrospinal fluid; D000690:Amyotrophic Lateral Sclerosis / Q000134:cerebrospinal fluid*; D001812:Blood-Brain Barrier; D005260:Female; D006801:Humans; D007854:Lead / Q000134:cerebrospinal fluid*; D008297:Male; D008875:Middle Aged; D008959:Models, Neurological
chemical_list: D000418:Albumins; D007854:Lead