Evaluation in dogs of cross-circulation in the treatment of acute hepatic necrosis induced by yellow phosphorus.
The efficacy of cross-circulation in the treatment of acute liver failure has been evaluated in dogs. Four of 5 dogs administered a dose of yellow phosphorus that is lethal 90% of the time survived after treatment by cross-circulation of whole blood for between 1 and 8 hr with a normal dog. In 2 normal unmatched dogs plasma cross-circulations were performed over a period of 31 days without any clinical or laboratory manifestation of hypersensitivity except for lymphocytotoxic antibody titer rise. The results suggest that whole blood cross-circulation is effective and imply that a single donor could be utilized for prolonged periods of plasma cross-circulation with avoidance of immunological consequences of whole blood exchange.
D000208:Acute Disease; D000818:Animals; D001783:Blood Flow Velocity; D056486:Chemical and Drug Induced Liver Injury / Q000209:etiology / Q000473:pathology / Q000628:therapy*; D003427:Cross Circulation; D003601:Cytotoxicity Tests, Immunologic; D004285:Dogs; D004305:Dose-Response Relationship, Drug; D007279:Injections, Subcutaneous; D008099:Liver / Q000473:pathology; D008111:Liver Function Tests; D008115:Liver Regeneration / Q000187:drug effects; D008214:Lymphocytes / Q000276:immunology; D009336:Necrosis; D010227:Parabiosis; D010758:Phosphorus / Q000633:toxicity*; D011517:Prothrombin Time
D010758:Phosphorus