A serial study of coagulation factors XII, XI and X in plasma in normal pregnancy and in pregnancy complicated by pre-eclampsia.
A serial study of coagulation factors XII, XI and X in plasma has been carried out on 60 primigravidae, prospectively comparing those who remained normal with those who developed pre-eclampsia. In the normal group of 48 patients, the levels of all factors rose as pregnancy advanced, a secondary increase in factors XI and X occurring in the puerperium. Cord levels of all three factors were depressed. In the pre-eclampsia group of 12 patients, factor XII was significantly higher than in the normal group throughout the study, while factors XI and X were slightly lower. Observed changes failed to support the idea of a strong primary role for the coagulation mechanism in the pathogenesis of pre-eclampsia.
D005170:Factor X / Q000032:analysis*; D005172:Factor XI / Q000032:analysis*; D005174:Factor XII / Q000032:analysis*; D005260:Female; D005312:Fetal Blood / Q000032:analysis; D006801:Humans; D049590:Postpartum Period; D011225:Pre-Eclampsia / Q000097:blood*; D011247:Pregnancy; D013997:Time Factors
D005170:Factor X; D005174:Factor XII; D005172:Factor XI