title: (D-Ala2)-Met-enkephalinamide: a potent, long-lasting synthetic pentapeptide analgesic.
abstract: [D-Ala2]-Met-enkephalinamide (DALA), a synthetic enkephalin analog designed by in vitro analysis, binds to opiate receptors almost as tightly as methionine-enkephalin. Since it is not susceptible to degradation by brain enzymes, low doses (5 to 10 micrograms) cause profound, long-lasting, morphine-like analgesia when microinjected into rat brain.
mesh_terms: D000698:Analgesia; D000818:Animals; D007700:Kinetics; D008024:Ligands; D009842:Oligopeptides / Q000378:metabolism / Q000494:pharmacology*; D010447:Peptide Hydrolases / Q000378:metabolism; D051381:Rats; D011955:Receptors, Drug; D013329:Structure-Activity Relationship
chemical_list: D008024:Ligands; D009842:Oligopeptides; D011955:Receptors, Drug; D010447:Peptide Hydrolases