title: Recurrence of astrocytoma of optic nerve after 48 years.
abstract: A tumour presumed to be a juvenile glioma of the optic nerve was removed by a Kronlein procedure from a 4-year old boy in 1925. In 1973 a severe proptosis made it necessary to remove the atrophic eye and a large retro-ocular tumour. Histological examination, supported by electron microscopy, showed the second tumour to be an anaplastic pilocytic astrocytoma. The possible histogenesis and this unusual behaviour pattern are discussed.
mesh_terms: D001254:Astrocytoma / Q000473:pathology*; D002675:Child, Preschool; D005134:Eye Neoplasms / Q000473:pathology*; D005910:Glioma / Q000473:pathology; D006801:Humans; D008297:Male; D008854:Microscopy, Electron; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000473:pathology*; D009900:Optic Nerve / Q000473:pathology* / Q000648:ultrastructure