Distribution and occurrence of amphetamine and p-hydroxyamphetamine in tissues of the rat after injection of d-amphetamine sulfate.
The distribution of amphetamine and the formation and distribution of its principal metabolite p-hydroxyamphetamine after the injection of relatively small amounts of d-amphetamine was examined in the rat. Amphetamine entered all organs readily and was rapidly eliminated. p-Hydroxyamphetamine was rapidly synthesised and it is suggested that substrate inhibition of hepatic hydroxylating enzymes occurs. In the brain, amphetamine was homogeneously distributed between the seven brain regions examined whereas p-hydroxyamphetamine was predominantly concentrated in the striatum.
D000661:Amphetamine / Q000378:metabolism*; D000662:Amphetamines / Q000378:metabolism*; D000818:Animals; D001921:Brain / Q000378:metabolism; D003619:Dansyl Compounds; D003913:Dextroamphetamine / Q000378:metabolism*; D008297:Male; D051381:Rats; D013997:Time Factors; D010136:p-Hydroxyamphetamine / Q000378:metabolism*
D000662:Amphetamines; D003619:Dansyl Compounds; D000661:Amphetamine; D010136:p-Hydroxyamphetamine; D003913:Dextroamphetamine