The effect of leukocyte-induced degradation products of albumin on the analgesic action of morphine.
The effect of leukocyte-induced human albumin degradation products (LPAD) on the analgesic potency of morphine was investigated. The degradation products given alone to the rats did not affect pain threshold; while combined with morphine, they potentiated its analgesic action. Moreover, the degradation products increased the concentration of morphine in the brain tissue.
D000418:Albumins / Q000378:metabolism*; D000700:Analgesics; D000818:Animals; D004357:Drug Synergism; D007962:Leukocytes / Q000201:enzymology*; D008297:Male; D009020:Morphine / Q000494:pharmacology*; D010455:Peptides / Q000008:administration & dosage / Q000494:pharmacology*; D051381:Rats
D000418:Albumins; D000700:Analgesics; D010455:Peptides; D009020:Morphine