title: [The use of inhalation tests for the diagnostick of chronic bronchitis in children (author's transl)].
abstract: In chronic non-specific lung diseases (CNSLD) an increased bronchial reaction to histamine aerosol inhalation is already well known. It was decided then to study the reactivity of bronchi to histamine inhalation in children within the epidemiological investigation on the influence of air pollution on the respiratory system of children. The aim of the study was to determine how in healthy population of children, living only in differently polluted environments, the frequency of the positive tests correlates with history of lung diseases, some pathological symptoms, level of air pollution etc. Results of the inhalation tests were also compared with other functional results of respiratory system, like: spirometrical, pneumo-tachographical, body-plethysmographical measurements, tests of mechanics of respiration, determination of lung transfer factor for CO etc. Numerous other laboratory determinations (level of alpha-antitrypsine, and x-ray examinations) were also performed and compared with the inhalation tests. In spite of expectations in the so called epidemiological "positives" as absolute lack of reaction to histamine was observed more frequently. Children with initial airways resistances were also weeker reacting to histamine provocation. Some parameters of lung function in children with hyperreactivity to histamine proved to be initially somewhat worse. The authors assume that some environmental factors may influence by occurrence the reactivity of air-ways provocation by inhalation. The need of general agreement and unification for the technique and interpretation of provocation tests was stressed out. The usefulness of the application of inhalatory tests in epidemiological studies on healthy populations needs further discussion.
mesh_terms: D000336:Aerosols; D000397:Air Pollution; D000403:Airway Resistance; D001980:Bronchi / Q000187:drug effects; D001991:Bronchitis / Q000175:diagnosis* / Q000209:etiology; D002648:Child; D002908:Chronic Disease; D006632:Histamine / Q000008:administration & dosage / Q000494:pharmacology; D006801:Humans; D010993:Plethysmography, Whole Body; D012129:Respiratory Function Tests / Q000379:methods*; D013268:Stimulation, Chemical
chemical_list: D000336:Aerosols; D006632:Histamine
vernacular_title: Die Anwendbarkeit von Inhalationstests in der Diagnostik der chronischen Bronchitis bei Kindern