title: Discrimination of narcotic drugs on 3H-fentanyl receptor binding.
abstract: Stereospecific opiate receptor binding was measured using specifically labeled fentanyl in the presence of an excess of either dextromoramide or levomoramide, only the former being the analgesic isomer. In a very large series of chemically related drugs, but of different pharmacological activity, it was possible to recognize compounds endowed with a potential morphine-like activity. Attempts were made to localize the opiate receptors within the neuronal cell.
mesh_terms: D000818:Animals; D001921:Brain / Q000648:ultrastructure; D003593:Cytoplasm / Q000378:metabolism; D004192:Discrimination, Psychological / Q000187:drug effects*; D005283:Fentanyl / Q000378:metabolism / Q000494:pharmacology*; D066298:In Vitro Techniques; D009294:Narcotics / Q000494:pharmacology*; D051381:Rats; D011955:Receptors, Drug / Q000187:drug effects; D013329:Structure-Activity Relationship; D013347:Subcellular Fractions / Q000378:metabolism
chemical_list: D009294:Narcotics; D011955:Receptors, Drug; D005283:Fentanyl