[Intensity of phospholipid and cholesterol synthesis in the brain and spinal cord of rabbits with experimental allergic encephelomyelitis].
Experimental allergic encephalomyelitis (EAE) was induced in rabbits by inoculation of homologous spinal cord myelin with Freund's adjuvant. During the paralytic stage of EAE rabbits were injected with 2-C14-acetate and sacrificed in two hours. As revealed, the intensity of phospholipid and cholesterol synthesis decreased markedly in rabbits with EAE not only in the lumbar part of the spinal cord (where the greatest lesions of myelin were localized), but also in the brain stem (where demyelinization was absent).
D000818:Animals; D001933:Brain Stem / Q000378:metabolism*; D002784:Cholesterol / Q000096:biosynthesis*; D004681:Encephalomyelitis, Autoimmune, Experimental / Q000378:metabolism*; D010743:Phospholipids / Q000096:biosynthesis*; D011817:Rabbits; D013116:Spinal Cord / Q000378:metabolism*
D010743:Phospholipids; D002784:Cholesterol
Intensivnost' sinteza fosfolipidov i kholesterina v golovnom mozge krolikov pri éksperimental'nom allergicheskom éntsefalomielete