Positive feedback hypothesis on development of essential hypertension.
A hypothesis is presented on a possible mechanism of development of the essential hypertension. The present theoretical consideration with Laplace's law and Poiseuille's law indicates that arteriolar constriction increases, unless the blood flow is reduced, both arterial blood pressure and vascular circumferential wall tension which is considered a trigger of medial hypertrophy of the constricted arteriole. If the medial hypertrophy aggravates the vascular constriction, it all the more increases arterial pressure and wall tension. Therefore, the initial arteriolar constriction, however slight, may progressively produce hypertension and augment medial hypertrophy by such a positive feedback mechanism.
D001158:Arteries / Q000473:pathology; D001794:Blood Pressure; D003250:Constriction; D005246:Feedback; D006973:Hypertension / Q000209:etiology*; D006984:Hypertrophy / Q000209:etiology; D008433:Mathematics; D008954:Models, Biological