The influence of smoking on the intersubject variation in pentazocine elimination.
The cumulative urinary excretion over 24 h of pentazocine, under conditions of acidic urinary pH, has been measured in smokers and non-smokers using both male and female subjects (seventy subjects in total). A restricted urban population was studied. An overall three-fold inter-subject variation in elimination was observed. The cumulative urinary excretion of pentazocine was normally distributed in both smokers and non-smokers. Smokers metabolize 40% more pentazocine than non-smokers. It is concluded that induction is principally responsible for the observed subject variability.
D000328:Adult; D004777:Environment; D005260:Female; D006801:Humans; D008297:Male; D010423:Pentazocine / Q000008:administration & dosage / Q000378:metabolism* / Q000652:urine; D012907:Smoking
D010423:Pentazocine