Fundamental studies on physiological and pharmacological actions of L-ascorbate 2-sulfate. I. On the hypolipidemic effects.
The effects of L-ascorbate 2-sulfate (AAS) on the lipid metabolism were examined in Triton-induced hyperlipemic mice, hypercholesterolemic and normal rats, the following results being obtained. 1) In Triton-induced hyperlipemic mice, AAS (300 mg/kg) significantly decreased the serum cholesterol level, while L-ascorbate (AA, 175 mg/kg) was found ineffective. 2)In hypercholesterolemic rats fed 0.5% cholesterol diet, the consecutive administration of AAS decreased the level of serum cholesterol and liver triacylglycerols. AA only slightly affected these levels. However, both AAS and AA prevented the unordinal increase in the liver weight caused by cholesterol feeding. 3)In normal rats, the administration of AAS over a 4-week period decreased the levels of serum cholesterol and liver triacylglycerols.
D000818:Animals; D000924:Anticholesteremic Agents / Q000494:pharmacology; D001205:Ascorbic Acid / Q000031:analogs & derivatives* / Q000494:pharmacology; D002784:Cholesterol / Q000378:metabolism; D002994:Clofibrate / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D005260:Female; D006937:Hypercholesterolemia / Q000188:drug therapy; D006949:Hyperlipidemias / Q000139:chemically induced / Q000188:drug therapy*; D050356:Lipid Metabolism; D008099:Liver / Q000187:drug effects / Q000378:metabolism*; D008297:Male; D051379:Mice; D011092:Polyethylene Glycols; D051381:Rats; D012737:Sex Factors; D014280:Triglycerides / Q000378:metabolism
D000924:Anticholesteremic Agents; D014280:Triglycerides; D011092:Polyethylene Glycols; D002784:Cholesterol; D002994:Clofibrate; D001205:Ascorbic Acid