Treatment of hypercholesterolemia with Secholex. A long-term clinical trial and comparison with cholestyramine.
The efficacy of an anion-exchange gel, Secholex, as a hypocholesterolemic agent was assessed in 46 patients in 4 different studies and the effects were compared with those of cholestyramine. All patients had severe Type II-a or II-b hyperlipoproteinemia. In short-term metabolic studies Secholex (15 g/day) and cholestyramine (16 g/day) decreased serum cholesterol levels and increased total fecal sterol output and serum methyl sterol concentration to a similar extent, but cholestyramine was more effective than Secholex in increasing fecal bile acid excretion. In crossover studies, the two drugs appeared to be equally effective in lowing serum cholesterol levels but the patients mostly preferred Secholex. Twenty patients were treated with Secholex over a two-year period. The average decrease in serum cholesterol levels from the mean pretreatment value of 406 mg/100 ml was 15% during the first year, and 13% during the second year. In 5 patients the serum cholesterol was permanently lowered by more than 20% (good responders), while in 7 patients the average reduction of serum cholesterol level during Secholex administration was less than 10% (non-responders). The serum triglyceride level was slightly decreased by Secholex in Type II-b patients but was unaltered in Type II-a patients. At the end of the treatment period, serum iron and vitamin B12 levels were normal but the serum folic acid concentration was reduced in eight of 20 patients. A dose--response study indicated that a similar cholesterol-lowering effect was obtained with daily doses of 9 and 15 g of Secholex. It is concluded that Secholex is a relatively safe drug which effectively reduces serum cholesterol levels in two-thirds of patients with severe hypercholesterolemia.
D000045:Acacia; D000328:Adult; D000837:Anion Exchange Resins / Q000627:therapeutic use*; D002784:Cholesterol / Q000097:blood; D002792:Cholestyramine Resin / Q000627:therapeutic use*; D003637:DEAE-Dextran / Q000031:analogs & derivatives / Q000627:therapeutic use*; D003911:Dextrans / Q000031:analogs & derivatives*; D004305:Dose-Response Relationship, Drug; D004338:Drug Combinations; D005243:Feces / Q000032:analysis; D005260:Female; D006801:Humans; D006937:Hypercholesterolemia / Q000097:blood / Q000188:drug therapy*; D007475:Ion Exchange Resins / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D013256:Steroids / Q000378:metabolism; D013261:Sterols / Q000097:blood; D014280:Triglycerides / Q000097:blood
D000837:Anion Exchange Resins; D003911:Dextrans; D004338:Drug Combinations; D007475:Ion Exchange Resins; D013256:Steroids; D013261:Sterols; D014280:Triglycerides; D002792:Cholestyramine Resin; C008093:Secholex; D003637:DEAE-Dextran; D002784:Cholesterol