title: Ferritin in Crohn's disease tissue: detection by electron microscopy.
abstract: Using immune electron microscopy, an attempt has been made to visualise viral particles in Crohn's disease tissue and faeces. No particles resembling viruses were observed, but in the absence of a specific antiserum a negative result does not exclude the presence of a virus, particularly if it is sparsely distributed. Compared with controls, an abundance of a 12 nm particle was found in all Crohn's disease tissue and one small intestinal lymphoma. This particle has been identified as ferritin and is unlikely to be of aetiological significance.
mesh_terms: D003106:Colon / Q000032:analysis / Q000648:ultrastructure; D003424:Crohn Disease / Q000382:microbiology / Q000473:pathology*; D005243:Feces; D005293:Ferritins / Q000032:analysis*; D006651:Histocytochemistry; D006801:Humans; D007082:Ileum / Q000032:analysis / Q000648:ultrastructure; D008223:Lymphoma / Q000473:pathology; D008854:Microscopy, Electron
chemical_list: D005293:Ferritins