[Effect of glutamine, thymidine and orotate on the nucleic acid content in the cell nuclei of the regenerating liver in sodium fluoride poisoning].
Sodium fluoride inhibits an increase of nucleic acids in the cells nuclei of the rat liver after a partial resection of this organ. Introduction of thymidine to the animals poisoned with sodium fluoride, contrary to glutamine and orotate, causes a sharp decrease in the amount of nuclei in 1 mg of tissue and normalization of the nucleic acid content in them. Changes in the mitotic activity may be connected with a disturbance in the normal ratio of the nucleic acids synthesis precursors.
D000818:Animals; D002467:Cell Nucleus / Q000032:analysis / Q000187:drug effects*; D004247:DNA / Q000032:analysis / Q000096:biosynthesis*; D005260:Female; D005458:Fluoride Poisoning / Q000378:metabolism*; D005973:Glutamine / Q000494:pharmacology*; D006498:Hepatectomy; D008115:Liver Regeneration / Q000187:drug effects*; D008297:Male; D009963:Orotic Acid / Q000494:pharmacology*; D012313:RNA / Q000032:analysis / Q000096:biosynthesis*; D051381:Rats; D013936:Thymidine / Q000494:pharmacology*; D013997:Time Factors
D005973:Glutamine; D009963:Orotic Acid; D012313:RNA; D004247:DNA; D013936:Thymidine
Vplyv hlutaminu, tymidynu ĭ orotatu na vmist nukleĭnovykh kyslot u iadrakh klityn regeneruiuchoĭ pechinky za intoksykatsiĭ ftorydom natriiu