Regulation of acetylcholine synthesis: does cytoplasmic acetylcholine control high affinity choline uptake?
When brain synaptosomes are obtained from animals that have been injected intravenously with [2H4]choline 1 minute before being killed, their high affinity [3H] choline uptake is correlated inversely with their acetylcholine content and directly with the rate at which they synthesize [2H4]acetylcholine. The control of such choline uptake by the cytoplasmic acetylcholine concentration is proposed as a mechanism regulating acetylcholine synthesis in cholinergic nerve terminals.
D000109:Acetylcholine / Q000096:biosynthesis* / Q000378:metabolism; D000818:Animals; D001285:Atropine / Q000494:pharmacology; D001693:Biological Transport, Active / Q000187:drug effects; D001921:Brain / Q000378:metabolism*; D002794:Choline / Q000378:metabolism*; D004597:Electroshock; D051379:Mice; D010095:Oxotremorine / Q000494:pharmacology; D010424:Pentobarbital / Q000494:pharmacology; D010433:Pentylenetetrazole / Q000494:pharmacology; D013574:Synaptosomes / Q000378:metabolism
D010095:Oxotremorine; D001285:Atropine; D010424:Pentobarbital; D002794:Choline; D000109:Acetylcholine; D010433:Pentylenetetrazole