Influence of phosphoserine on the performance of rats on the rotarod.
The anti-fatigue effect of phosphoserine, L-serine and a mixture of sodium phosphate and L-serine has been studied in rats. Phosphoserine orally administered induced a statistically significant anti-fatigue effect in rats of both sexes submitted to a training test by rotarod, with 14 sessions in 3 days. Furthermore, phosphoserine was utilized better than the mixture of sodium phosphate and L-serine, whereas L-serine alone induced no effect. Therefore the effect of phosphoserine seems to be due to the phosphoryl bond.
D000818:Animals; D005221:Fatigue; D005260:Female; D008297:Male; D009943:Organophosphorus Compounds / Q000494:pharmacology; D010710:Phosphates / Q000494:pharmacology; D005082:Physical Exertion / Q000187:drug effects*; D051381:Rats; D012694:Serine / Q000031:analogs & derivatives* / Q000494:pharmacology; D012964:Sodium / Q000494:pharmacology; D013997:Time Factors
D009943:Organophosphorus Compounds; D010710:Phosphates; D012694:Serine; D012964:Sodium