title: The effect of intravenous infusion of synthetic human gastrin-I on lower esophageal sphincter (LES) pressure in the dog and its relation to gastrin level.
abstract: To demonstrate the relation between gastrin level and lower esophageal sphincter (LES) pressure, experiments with intravenous infusions of synthetic human gastrin-I (SHG-I) were performed in anaesthetized dogs. The results show that infusions with 5 mug-kg-1-h-1 SHG-I have an initially increasing effect on LES pressure but produce unphysiologically high gastrin blood levels. Physiological levels of gastrin were measured only using an infusion dose of 0.5 mug-kg-1-h-1, which was below the threshold for increasing LES pressure.
mesh_terms: D000818:Animals; D004285:Dogs; D004943:Esophagogastric Junction / Q000187:drug effects* / Q000502:physiology; D005260:Female; D005755:Gastrins / Q000008:administration & dosage / Q000097:blood / Q000494:pharmacology*; D007275:Injections, Intravenous; D008297:Male; D011312:Pressure; D013268:Stimulation, Chemical
chemical_list: D005755:Gastrins