Protective effect of mucin on experimental gastric cancer induced by N-methyl-N'-nitro-N-nitrosoguanidine plus sodium chloride in rats.
Studies were made on the effect of mucin on the induction of gastric carcinomas by N-methyl-N'-nitro-N-nitrosoguanidine (MNNG), with or without sodium chloride, in male Wistar rats. Seven groups of rats were treated as follows: Group 4 was given continuously 50 mg MNNG/liter solution to drink and 1 ml of saturated sodium chloride once a week and fed on stock diet supplemented with 4% mucin. Group 2 was given 50 mg MNNG/liter solution and fed on stock diet supplemented with 4% mucin. Group 3 received 1 ml of saturated sodium chloride once a week and 50 mg MNNG/liter solution to drink. Group 1 was treated with MNNG only. Group 5 was fed on stock diet supplemented with 4% mucin. Group 6 was given sodium chloride only. Group 7 was untreated. The incidence of gastric cancer in Group 3 was significantly higher than that in Group 4 (P less than 0.05) or in Group 1 (P less than 0.05). The difference in the incidence of gastric cancer in Groups 2 and 4, and of intestinal tumors in Groups 1 to 4 were not statistically significant. No malignant tumors were seen in Groups 5, 6, and 7. Thus mucin reduced the high incidence of gastric cancer induced by MNNG and sodium chloride to the level induced by MNNG alone, but it had no effect on the incidence of intestinal tumors. The effect of mucin in preventing destruction of the gastric mucosal barrier by sodium chloride and so reducing the induction of gastric cancer is discussed.
D000230:Adenocarcinoma / Q000139:chemically induced; D000818:Animals; D001835:Body Weight / Q000187:drug effects; D002277:Carcinoma / Q000139:chemically induced; D004357:Drug Synergism; D005753:Gastric Mucosa / Q000187:drug effects; D007414:Intestinal Neoplasms / Q000139:chemically induced; D008297:Male; D008769:Methylnitronitrosoguanidine / Q000633:toxicity; D009077:Mucins / Q000494:pharmacology*; D009374:Neoplasms, Experimental / Q000139:chemically induced; D009604:Nitrosoguanidines / Q000633:toxicity; D051381:Rats; D012513:Sarcoma, Experimental / Q000139:chemically induced; D012965:Sodium Chloride / Q000633:toxicity; D013274:Stomach Neoplasms / Q000139:chemically induced*
D009077:Mucins; D009604:Nitrosoguanidines; D008769:Methylnitronitrosoguanidine; D012965:Sodium Chloride