Effects of DOCA on circulation, renal functions, body fluids and tissue electrolytes.
Desoxycorticosterone acetate (DOCA) was administered subcutaneously to 11 normal dogs (2 mg/kg/day) for 4 days. Few changes were observed in cardiovascular and renal functions except that the glomerular filtration rate was significantly increased. Total body water and plasma volume increased with a reduction of red blood cell volume. Hematocrit, plasma osmolality and total protein concentrations were decreased. The plasma K+ levels were lowered despite unchanged plasma concentrations of Na+, Ca++, Mg++, Cl- and phosphorus. The heart showed an increase in Na+ content and a decrease in K+, Ca++, phosphorus and total lipids. The skeletal muscle showed a decrease in Ca++ and an increase in Cl- and water content. The skin revealed a reduction of K+ and an elevation of Cl-. This study showed that a DOCA-induced depletion of K+ from skeletal muscle did not occur in normally fed dogs that did not receive a large sodium load.
D000818:Animals; D001798:Blood Proteins / Q000378:metabolism; D001826:Body Fluids / Q000187:drug effects*; D001834:Body Water / Q000187:drug effects; D001835:Body Weight / Q000187:drug effects; D003900:Desoxycorticosterone / Q000494:pharmacology*; D004285:Dogs; D004573:Electrolytes / Q000097:blood; D005260:Female; D006321:Heart / Q000187:drug effects; D006439:Hemodynamics / Q000187:drug effects*; D007668:Kidney / Q000187:drug effects* / Q000502:physiology; D050356:Lipid Metabolism; D008297:Male; D014882:Water-Electrolyte Balance / Q000187:drug effects
D001798:Blood Proteins; D004573:Electrolytes; D003900:Desoxycorticosterone