title: Population kinetics of antral gastrin cells in the mouse.
abstract: The proliferation of antral gastrin cells has been studied in adult mice by combining their immunoperoxidase identification on semithin Epon sections with radioautography after single or multiple injections of [3H]thymidine. After a single injection, nuclear uptake of [3H]thymidine was observed in 0.25% of the well-differentiated gastrin cells. Ten days after six successive injections of the precursor, the labeling index reached 4.5%. This indicated that the renewal of the gastrin cell population was very slow. The turnover time was roughly estimated at 2 to 4 months. Analysis of the labeling index curves obtained during and after the administration of [3H]thymidine confirmed that the majority of the gastrin cells were renewed through replication of other gastrin cells. However, differentiation of a fraction of this gastrin cell population from "other" cells in the antrum could not be excluded.
mesh_terms: D000818:Animals; D001345:Autoradiography; D002465:Cell Movement; D004261:DNA Replication; D005753:Gastric Mucosa / Q000166:cytology; D005755:Gastrins; D006207:Half-Life; D008297:Male; D051379:Mice; D008938:Mitosis; D008940:Mitotic Index; D011706:Pyloric Antrum / Q000166:cytology*; D013936:Thymidine / Q000378:metabolism
chemical_list: D005755:Gastrins; D013936:Thymidine