title: [Microbiologic transformation of microcrystalline cortisone acetate into prednisone].
abstract: The process of transformation of microcystalline acetate cortisone by two mycobacteria (Mycobacterium album and Mycobacterium globiforme) has been studied. Optimal conditions for the process have been established: amount of biomass of both cultures, concentration of the initial substrate and required concentration of the surfactant--antifoamsilane. The anzymic activity of the cultures reaches maximum if the following three requirements are met: utilization of cells separated from the medium, substrate in the microcrystalline state and surfactant of the antifoamsilane type.
mesh_terms: D003348:Cortisone / Q000378:metabolism*; D009161:Mycobacterium / Q000378:metabolism*; D011241:Prednisone / Q000096:biosynthesis*
chemical_list: D003348:Cortisone; D011241:Prednisone
vernacular_title: Mikrobiologicheskaia transformasiia mikrokristallicheskogo atsetata kortizona v prednizon