Intracisternal virus-like particles in two guinea pig mammary adenocarcinomas.
Virus-like particles were found in spontaneously arising mammary adenocarcinomas from 2 male guinea pigs. The type-B particles were 100 nm in diameter and budded from the apex of stalks into cisternae. Examination of normal and neoplastic tissues from other guinea pigs failed to reveal similar particles. A review of the literature revealed that of the 16 known cases of mammary adenocarcinomas in guinea pigs, 5 have occurred in male animals. The apparent propensity for spontaneous mammary adenocarcinomas in males of this species is discussed in relation to the possible etiologic agents responsible for them.
D000230:Adenocarcinoma / Q000382:microbiology / Q000662:veterinary*; D000818:Animals; D005260:Female; D006168:Guinea Pigs; D007181:Inclusion Bodies, Viral; D008297:Male; D008321:Mammary Glands, Animal / Q000382:microbiology / Q000648:ultrastructure; D009369:Neoplasms / Q000382:microbiology / Q000662:veterinary*; D012376:Rodent Diseases / Q000382:microbiology*