[The frequency and form of manifestation of liver damage under INH therapy].
It is reported on 305 clinically examined patients with the diagnosis of a functional colon syndrome. In 65 patients somatic diseases were found to be the possible triggering factors. In contrast to a comparative group in the other 240 patients in the former anamnesis more frequently allergies, appendectomies and chronic application of purgatives were to be established. The most frequent complaints were irregularity of defaecation in form of spastic obstipation (62.9%) or diarrhoea (35.4%), intolerance to foodstuff (100%), pain in the colon(66.7%) and meteorism (65.4%). The 4th decennium was most frequently concerned in men as well as in women.
D000437:Alcoholism / Q000175:diagnosis; D000469:Alkaline Phosphatase / Q000378:metabolism; D001663:Bilirubin / Q000097:blood; D002779:Cholestasis / Q000139:chemically induced; D006529:Hepatomegaly / Q000139:chemically induced; D006801:Humans; D007538:Isoniazid / Q000009:adverse effects*; D008099:Liver / Q000187:drug effects*; D000637:Transaminases / Q000378:metabolism; D014397:Tuberculosis, Pulmonary / Q000188:drug therapy
D000637:Transaminases; D000469:Alkaline Phosphatase; D001663:Bilirubin; D007538:Isoniazid
Uber die Häufigkeit und Manifestationsform von Leberschädigungen unter INH-Therapie