[Myocardial changes in rats after considerable physical exertion and the effect of pyridoxilate on the severity of these changes].
Under significant physical exercises the myocardium of rats displays distinct enzymopathy, increased permeability of the cell membranes with a considerable dispersion of plasma proteins and damage to the ultrastructures of the myocytes. The employment of pyridoxilate reduces the severity of the damaging reaction, and to some extent normalizes the structure of the cellular and sub-cellular elements of the myocardium. This indicates to the prospects of using the regulators of cellular respiration under total and tissue hypoxia.
D000818:Animals; D004338:Drug Combinations; D005993:Glycerolphosphate Dehydrogenase / Q000378:metabolism; D006003:Glycogen / Q000378:metabolism; D006038:Glyoxylates / Q000494:pharmacology; D006321:Heart / Q000503:physiopathology*; D000860:Hypoxia / Q000503:physiopathology*; D007770:L-Lactate Dehydrogenase / Q000378:metabolism; D008297:Male; D009206:Myocardium / Q000378:metabolism*; D005082:Physical Exertion; D011736:Pyridoxine / Q000031:analogs & derivatives* / Q000494:pharmacology; D011767:Pyruvate Decarboxylase / Q000494:pharmacology; D051381:Rats; D013385:Succinate Dehydrogenase / Q000378:metabolism; D000637:Transaminases / Q000494:pharmacology
D004338:Drug Combinations; D006038:Glyoxylates; C001310:pyridoxilate; D006003:Glycogen; D005993:Glycerolphosphate Dehydrogenase; D007770:L-Lactate Dehydrogenase; D013385:Succinate Dehydrogenase; D000637:Transaminases; D011767:Pyruvate Decarboxylase; D011736:Pyridoxine
Izmeneniia miokarda u krys pri znachitel'noĭ fizicheskoĭ nagruzke i vliianie piridoksilata na vyrazhennost' etikh izemeniĭ