A hypothesis: the role of a high-risk male in the etiology of cervical carcinoma: a correlation of epidemiology and molecular biology.
Certain impressive epidemiological evidence appearing in the last few years leads to the conclusion that some males are more prone to have a spouse with squamous cancer of the cervix than others. Advances in knowledge in other fields, especially at the molecular biological level, enable speculation on reasons for this curious conclusion. These readily testable theories, together with an outline of the evidence on which they rest, form the substance of this hypothesis.
D002294:Carcinoma, Squamous Cell / Q000209:etiology*; D002449:Cell Aggregation / Q000187:drug effects; D004273:DNA, Neoplasm / Q000378:metabolism; D005260:Female; D006657:Histones / Q000494:pharmacology; D006801:Humans; D008297:Male; D008393:Marriage; D008967:Molecular Biology; D010412:Penile Neoplasms / Q000473:pathology*; D011471:Prostatic Neoplasms / Q000473:pathology*; D012306:Risk; D002583:Uterine Cervical Neoplasms / Q000209:etiology*
D004273:DNA, Neoplasm; D006657:Histones