title: Evidence for the presence of a vasoactive substance (possibly involved in the aetiology of cerebral arterial spasm) in cerebrospinal fluid from patients with subarachnoid haemorrhage.
abstract: Cerebrospinal fluid from patients with subarachnoid haemorrhage and cerebral arterial spasm contracted the isolated basilar artery and potentiated contractions produced by 5-hydroxytryptamine, noradrenaline, and six prostaglandins. The unidentified substance in cerebrospinal fluid probably plays a role in the aetiology of cerebral arterial spasm.
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D001488:Basilar Artery / Q000187:drug effects; D002118:Calcium / Q000494:pharmacology; D005260:Female; D006801:Humans; D066298:In Vitro Techniques; D002532:Intracranial Aneurysm / Q000150:complications / Q000503:physiopathology; D002546:Ischemic Attack, Transient / Q000134:cerebrospinal fluid / Q000209:etiology*; D008274:Magnesium / Q000494:pharmacology; D008297:Male; D008875:Middle Aged; D009638:Norepinephrine / Q000494:pharmacology; D011188:Potassium / Q000494:pharmacology; D011453:Prostaglandins / Q000494:pharmacology; D012701:Serotonin / Q000494:pharmacology; D013345:Subarachnoid Hemorrhage / Q000134:cerebrospinal fluid* / Q000150:complications; D014662:Vasoconstrictor Agents / Q000037:antagonists & inhibitors / Q000494:pharmacology
chemical_list: D011453:Prostaglandins; D014662:Vasoconstrictor Agents; D012701:Serotonin; D008274:Magnesium; D011188:Potassium; D002118:Calcium; D009638:Norepinephrine