Acute clinical hypocalcemic myocardial depression during rapid blood transfusion and postoperative hemodialysis: a preventable complication.
Despite experimental evidence that myocardial depression resulting from rapid transfusion of ACD blood (citrate binds ionic calcium) is avoidable by simultaneous calcium administration, most hypovolemic patients receive calcium either after transfusion or not at all. Similar iatrogenic hypocalcemic myocardial depression occurs in normovolemic patients with known myocardial damage who are dialyzed for acute uremia when ACD blood prime is used at high initial flow rates (350 c.c. per minute) and when dialysis is performed against low calcium dialysate (2.5 mEq. per liter or less). This study tests the hypotheses that (1) rapid transfusion of as little as one unit of CPD blood causes a significant reduction in ionized calcium, (2) the depressive effect of CPD blood is significant and similar to that of ACD blood, (3) rapid blood transfusion (ACD or CPD) is safe if calcium is given simultaneously, (4) addition of calcium to the extracorporeal heparinized blood prime used in dialysis prevents initial depression, and (5) hemodynamic instability during dialysis is prevented when the dialysate is normocalcemic. From the results of our study, we made the following conclusions: (1) Ionized calcium is reduced significantly by rapid transfusion of CPD blood; (2) acute myocardial depression noted with CPD blood is similar to that previously observed with ACD blood and is prevented during transfusion of either type of blood by simultaneous calcium administration; and (3) hemodialysis in patients who have had cardiac surgery is safe if calcium is added to blood prime and dialysate is made normocalcemic.
D001793:Blood Preservation; D002118:Calcium / Q000008:administration & dosage; D002302:Cardiac Output / Q000187:drug effects; D002951:Citrates / Q000008:administration & dosage; D006439:Hemodynamics / Q000187:drug effects; D006488:Hemostasis, Surgical; D006801:Humans; D006996:Hypocalcemia / Q000517:prevention & control*; D009200:Myocardial Contraction / Q000187:drug effects; D009204:Myocardial Revascularization; D006435:Renal Dialysis / Q000009:adverse effects*; D065227:Transfusion Reaction; D014511:Uremia / Q000628:therapy
D002951:Citrates; D002118:Calcium