Coronary arterial smooth muscle contraction by a substance released from platelets: evidence that it is thromboxane A2.
When human platelets are aggregated by thrombin, material is released that rapidly contracts strips of spirally cut porcine coronary artery. Prevention of the contraction by indomethacin suggested mediation by a prostaglandin. The contraction produced by aggregating platelets was unlike those produced by prostaglandins E2, F2alpha, G2, or H2, but resembled that evoked by thromboxane A2, which is formed by platelets during aggregation.
D001158:Arteries; D001792:Blood Platelets / Q000378:metabolism; D003326:Coronary Circulation / Q000187:drug effects*; D006801:Humans; D006880:Hydroxy Acids / Q000302:isolation & purification*; D008297:Male; D009119:Muscle Contraction / Q000187:drug effects; D009130:Muscle, Smooth; D010974:Platelet Aggregation; D011453:Prostaglandins / Q000097:blood* / Q000378:metabolism / Q000494:pharmacology; D011714:Pyrans / Q000302:isolation & purification*; D014662:Vasoconstrictor Agents
D006880:Hydroxy Acids; D011453:Prostaglandins; D011714:Pyrans; D014662:Vasoconstrictor Agents