title: The influence of prostaglandin E2 on the electroencephalogram of normal subjects and epileptic patients.
abstract: In 1973 R.C. Lyneham and others warned against the possible epileptogenic effect of prostaglandins. We studied the influence of this substance on the electroencephalogram of 53 subject (31 non-epileptics and 22 epileptics) before and during the administration of PG E2. Forty-eight tracings remained unchanged, four showed a slight improvement and one showed some worsening during infusion of PG E2. One patient, suffering from daily psychomotor attacks had, accidentally a fit during the trial. It can be concluded that PG E2 does not alter the electroencephalogram in a significant way and that it does not induce epileptic seizures.
mesh_terms: D004827:Epilepsy / Q000139:chemically induced*; D005260:Female; D006801:Humans; D008297:Male; D011247:Pregnancy; D011458:Prostaglandins E / Q000494:pharmacology*
chemical_list: D011458:Prostaglandins E