[Contribution to stability test of daunoblastin solutions (author's transl)].
It is known that drugs are not unlimitedly stable. Dilutions of the antineoplastic agent daunoblastin used in the clinic and experimental work, were examined, whether they could be stored for several days. By means of impulscytophotometry, spectral-photometric measurements, counting of surviving cells and estimation of DNA-synthesis after culturing pieces of tissue in the presence of daunoblastin it could be established that this drug, diluted even four days ago, still possesses sufficient activity.
D000818:Animals; D002286:Carcinoma, Ehrlich Tumor / Q000188:drug therapy / Q000473:pathology; D002478:Cells, Cultured / Q000187:drug effects; D003630:Daunorubicin / Q000494:pharmacology* / Q000627:therapeutic use; D004355:Drug Stability; D004356:Drug Storage; D051379:Mice; D009924:Organ Culture Techniques; D012996:Solutions; D013997:Time Factors
D012996:Solutions; D003630:Daunorubicin
Beitrag zur Uberprüfung der Stabilität von Daunoblastinlösungen