title: The interaction of ethanol and delta9-tetrahydrocannabinol in man: effects on perceptual, cognitive and motor functions.
abstract: Twelve paid student volunteers (8 male, 4 female) were used in a double-blind crossover experiment to investigate the effects of delta9-tetrahydrocannabinol (THC) alone, and in combination with ethanol, on human perceptual, cognitive and motor functions. Both THC (10 mg/70 kg) and ethanol (0-5 g/kg) had little effect when administered alone. The combination of drugs, however, induced a significnat decrement in performance in some of the tests and this interaction was considered to be at least additive. The peak blood ethanol concentration was higher (P = 0-05) when subjects received both ethanol and THC than when they received ethanol alone.
mesh_terms: D000293:Adolescent; D000328:Adult; D003071:Cognition / Q000187:drug effects*; D003864:Depression, Chemical; D013759:Dronabinol / Q000494:pharmacology*; D004357:Drug Synergism; D000431:Ethanol / Q000097:blood / Q000494:pharmacology*; D005260:Female; D006801:Humans; D008297:Male; D009048:Motor Skills / Q000187:drug effects*; D010465:Perception / Q000187:drug effects*; D010919:Placebos; D011187:Posture; D011930:Reaction Time / Q000187:drug effects
chemical_list: D010919:Placebos; D000431:Ethanol; D013759:Dronabinol