title: Cytoplasmic aldo-keto reductases: a class of drug metabolizing enzymes.
abstract: Aldehyde and ketone xenobiotic substances are preferentially reduced to alcohols by cytoplasmic enzymes in mammals. These enzymes are widely distributed in the tissues, have broad substrate specificities, have similar physical-chemical characteristics, and require reduced nicotinamide adenine dinucleotide as cofactor for the reductions. These reductases define a system of detoxification for aldehyde and ketone groups.
mesh_terms: D000445:Aldehyde Oxidoreductases / Q000378:metabolism*; D000818:Animals; D002417:Cattle; D002645:Chickens; D003593:Cytoplasm / Q000201:enzymology*; D004285:Dogs; D006168:Guinea Pigs; D006736:Horses; D006801:Humans; D008658:Inactivation, Metabolic; D007658:Ketone Oxidoreductases / Q000378:metabolism*; D007668:Kidney / Q000201:enzymology; D008099:Liver / Q000201:enzymology; D051379:Mice; D011817:Rabbits; D013552:Swine; D014422:Turkeys
chemical_list: D000445:Aldehyde Oxidoreductases; D007658:Ketone Oxidoreductases