Effect of triamcinolone on the ultrastructure of mouse hepatocytes.
Premature female mice were injected daily with 1.5 mg/kg body weight of triamcinolone diacetate for 10 and 21 consecutive days. Electron-microscopic study of hepatocytes indicated the formation of 'giant' mitochondria concomitant with a marked increase in the number and size of lipid droplets. Hypertrophied mitochondria and enlarged lipid droplets were found to be in a close topographical association. The mechanism of mitochondrial enlargement is discussed as well as the latters' role in the hepatocytes' lipid metabolism.
D000818:Animals; D003593:Cytoplasm / Q000378:metabolism / Q000648:ultrastructure; D005260:Female; D050356:Lipid Metabolism; D008099:Liver / Q000187:drug effects* / Q000648:ultrastructure; D051379:Mice; D008930:Mitochondria, Liver / Q000187:drug effects / Q000648:ultrastructure; D014221:Triamcinolone / Q000494:pharmacology*
D014221:Triamcinolone