title: Radical surgical treatment of craniopharyngioma.
abstract: There is evidence from this publication and those of Matson and colleagues that a determined effort at total excision of these tumors as the initial therapy is a tenable course of action. The main bases for this concept are: (1) that the dense gliosis characteristically intervening between these epithelial tumors and normal brain constitutes a margin of safety for the surgeon at least for the first several years such tumors are growing in the 3rd ventricle; (2) improved early diagnosis and better operative instruments, magnification, lighting, and technique are decreasing operative morbidity and mortality; and (3) new knowledge and new replacement therapy are reducing the burden of the metabolic and endocrine defects. Competing with this is the concept that rotationally delivered or even more precisely focused high energy photons and intracavitary beta-radiation have lower morbidity and mortality. The detailed and long term data on which to draw conclusions are not yet available. My medical colleagues and I are preparing case-by-case tables with all of the relevant facts to supply one component of the total picture.
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D001932:Brain Neoplasms / Q000401:mortality / Q000503:physiopathology / Q000601:surgery*; D002551:Cerebral Ventricle Neoplasms / Q000601:surgery; D002648:Child; D003397:Craniopharyngioma / Q000401:mortality / Q000503:physiopathology / Q000601:surgery*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011182:Postoperative Care