Anticonvulsant activity of enzyme inhibitors in rats.
Three liver microsomal enzyme inhibitors, proadifen, 2,4-dichloro-6-phenylphenoxyethyldiethylamine, and 2,4-dichloro-6-phenylphenoxyethylamine, and a hepatotoxic agent, carbon tetrachloride, were tested for anticonvulsant activity in adult male albino rats using the maximal electroshock seizure technique. All four substances exhibited significant anticonvulsant activity 1 hr after intraperitoneal administration. This protection was absent when tested 24 hr later.
D000818:Animals; D000927:Anticonvulsants / Q000494:pharmacology*; D002251:Carbon Tetrachloride / Q000494:pharmacology; D004791:Enzyme Inhibitors / Q000494:pharmacology*; D005029:Ethylenediamines / Q000494:pharmacology; D006614:Hindlimb / Q000187:drug effects; D008297:Male; D010627:Phenethylamines / Q000494:pharmacology; D011335:Proadifen / Q000494:pharmacology; D051381:Rats; D012018:Reflex / Q000187:drug effects
D000927:Anticonvulsants; D004791:Enzyme Inhibitors; D005029:Ethylenediamines; D010627:Phenethylamines; D011335:Proadifen; D002251:Carbon Tetrachloride