Effects of splenectomy on production of poly I:C induced serum interferon in rabbits.
Splenectomy in rabbits causes a temporary reduction in interferon responding capacity of Poly I:C, followed by a period of hyperreactivity. At the same time a fraction of interferon with slightly different physiocochemical properties emerges. This could indicate that the spleen plays a relatively important role in the interferon response to Poly I:C. Splenectomy could be followed by the development of a compensatory cell population responsible for the production of interferon with slightly different molecular weight, isoelectric point and stability in urea.
D000818:Animals; D004355:Drug Stability; D005260:Female; D007372:Interferons / Q000032:analysis / Q000097:blood*; D007526:Isoelectric Point; D008297:Male; D008970:Molecular Weight; D011070:Poly I-C / Q000494:pharmacology*; D011817:Rabbits; D013154:Spleen / Q000502:physiology*; D013156:Splenectomy; D014508:Urea / Q000494:pharmacology
D014508:Urea; D007372:Interferons; D011070:Poly I-C