RNA synthesis in alpha-amanitin-poisoned rats: prevention of recovery by inhibition of protein synthesis.
The treatment with cycloheximide of rats previously poisoned with alpha-amanitin hinders the recovery of RNA synthesis observed in the liver of rats treated with alpha-amanitin alone. The recovery of RNA synthesis can be ascribed to the capability of poisoned rats to synthesize new RNA-polymerase II.
D000546:Amanitins / Q000633:toxicity*; D000818:Animals; D002467:Cell Nucleus / Q000378:metabolism; D003513:Cycloheximide / Q000494:pharmacology; D008099:Liver / Q000187:drug effects / Q000378:metabolism* / Q000648:ultrastructure; D008297:Male; D009963:Orotic Acid / Q000378:metabolism; D012313:RNA / Q000096:biosynthesis*; D051381:Rats; D013997:Time Factors
D000546:Amanitins; D009963:Orotic Acid; D012313:RNA; D003513:Cycloheximide