Effects of acute administration of delta9-tetrahydrocannabinol on pulmonary hemodynamics of anesthetized dogs.
I.v. administration of delta9-THC (2.5 mg/kg) To anesthetized dogs resulted in a decrease in heart rate, pulmonary blood flow (PBF), and a significant increase in pulmonary artery pressure (PAP) and total pulmonary vascular resistance (PVR). The increase in PVR to delta9-THC was significantly reduced by cardiac pacing, and was virtually abolished either by bilateral vagotomy or by pretreatment with hexamethonium. The data indicated the delta9-THC induced elevation of PVR was mediated via reflexogenic mechanisms involving afferent vagi and efferent autonomic pathways.
D000818:Animals; D002188:Cannabis / Q000494:pharmacology*; D004285:Dogs; D013759:Dronabinol / Q000494:pharmacology*; D006439:Hemodynamics / Q000187:drug effects*; D008168:Lung / Q000098:blood supply*; D012039:Regional Blood Flow / Q000187:drug effects
D013759:Dronabinol