Correlation between myocardial and plasma concentration of digitoxin and its metabolites with special reference to digitoxin radio-immunoassay.
According to our prevous study, the metabolites of digitoxin show nearly dentical affinity with digitoxin antibody. The present study reveals relatively constant ratio of heart to plasma in total 3H-counts, and the concentration of metabolites are ver similar between the two throughout the time investigated which indicates digitoxin concentration of plasma as determined by radioimmunoassay reflects well that of myocardium, although it may contain metabolites.
D000818:Animals; D002415:Cats; D002855:Chromatography, Thin Layer; D004074:Digitoxin / Q000097:blood / Q000378:metabolism* / Q000506:poisoning; D009206:Myocardium / Q000378:metabolism*; D011863:Radioimmunoassay
D004074:Digitoxin