[Brucellosis protective antigen, its chemical and immunobiological characteristics].
The data on brucella nontoxic protective antigen without any sensitizing properties isolated from the cell wall of brucella are presented. The antigen had a marked protective effect against the experimental infection for 3-4 months after a single immunization of guinea pigs.Molecular heterogeneity of the antigen, which is mainly a protein-polysaccharide complex, is given. High- and low-molecular fractions detected by gel filtration technique differed according to the chemical and immunobiological characteristics. The high-molecular fraction of the antigen was found to be highly immunogenic and serologically active.
D000818:Animals; D000917:Antibody Formation; D000942:Antigens, Bacterial; D002004:Brucella Vaccine; D002006:Brucellosis / Q000517:prevention & control*; D006168:Guinea Pigs; D014611:Vaccination
D000942:Antigens, Bacterial; D002004:Brucella Vaccine
Brutselleznyĭ protektivnyĭ antigen, ego khimicheskaia i immunologicheskaia kharakteristika