Application of trichloroacetyl isocyanate to NMR analysis of steroids of pharmaceutical interest I: corticosteroids and chemically related compounds.
The trichloroacetyl carbamates of 38 corticosteroids and chemically related compounds were prepared, and their NMR spectra in deuterochloroform were obtained. The effects of the introduction of a number of functional groups on the chemical shift of the carbamate proton signals were determined.
D000107:Acetylation; D000305:Adrenal Cortex Hormones / Q000032:analysis*; D002219:Carbamates; D055598:Chemical Phenomena; D002621:Chemistry; D003485:Cyanates; D006914:Hydroxysteroids / Q000032:analysis; D009682:Magnetic Resonance Spectroscopy; D008722:Methods
D000305:Adrenal Cortex Hormones; D002219:Carbamates; D003485:Cyanates; D006914:Hydroxysteroids