Quantitation of ineffective erythropoiesis from the incorporation of [15N] delta-aminolaevulinic acid and [15N] glycine into early labelled bilirubin. I. Normal subjects.
The incorporation of [15N] glycine into early labelled bilirubin and haemoglobin haem was measured in four haematologically normal subjects, using the clearance of [14C] bilirubin to measure total bilirubin production rate. Hepatic haem turnover was calculated from the incorporation of [15N]=sigma-aminolaevulinic acid into early labelled bilirubin. From the exprimental data previously published data in normal subjects a method is derived for the quantitation of ineffective erythropoiesis which can be applied to similar studies in patients with haematological disorders.
D000368:Aged; D000622:Aminolevulinic Acid / Q000378:metabolism*; D001663:Bilirubin / Q000096:biosynthesis* / Q000378:metabolism; D004920:Erythropoiesis; D005260:Female; D005998:Glycine / Q000378:metabolism*; D006418:Heme / Q000096:biosynthesis; D006801:Humans; D007982:Levulinic Acids / Q000378:metabolism*; D008297:Male; D008722:Methods; D008875:Middle Aged
D007982:Levulinic Acids; D006418:Heme; D000622:Aminolevulinic Acid; D001663:Bilirubin; D005998:Glycine