Replacement of a chlorine with a methylsulfonyl group in the metabolism of propachlor (2-chloro-N-isopropylacetanilide).
Urine from rats and sheep given single doses of [14C]propachlor contained 14C metabolites in which the chlorine of propachlor was replaced by a methylsulfonyl group. Methylsulfonyl-containing metabolites were also isolated from the urine of rats given an intraperitoneal dose of the cysteine conjugate of [14C]propachlor; this indicated that the methylsulfonyl-containing metabolites resulted from metabolic reactions subsequent to the mercapturic acid pathway.
D000081:Acetamides / Q000138:chemical synthesis; D000083:Acetanilides / Q000031:analogs & derivatives* / Q000378:metabolism / Q000652:urine; D000111:Acetylcysteine / Q000378:metabolism / Q000652:urine; D000818:Animals; D002713:Chlorine / Q000378:metabolism*; D003545:Cysteine / Q000378:metabolism / Q000652:urine; D005260:Female; D051381:Rats; D012756:Sheep; D013450:Sulfones / Q000378:metabolism*
D000081:Acetamides; D000083:Acetanilides; D013450:Sulfones; C011088:propachlor; D002713:Chlorine; D003545:Cysteine; D000111:Acetylcysteine