Pertussis vaccine oedema: an experimental model for the action of penicillamine-like drugs.
A delayed hypersensitivity response was induced in the rat paw using pertussis vaccine. Oedema was measured after the challenging injection. D-penicillamine and levamisole enhanced the response, while indomethacin suppressed it. This model is useful to distinguish the effects of anti-inflammatory drugs from those like D-Penicillamine which have a specific activity in rheumatoid arthritis.
D000818:Animals; D004195:Disease Models, Animal; D004334:Drug Administration Schedule; D004487:Edema / Q000209:etiology*; D005260:Female; D005620:Freund's Adjuvant / Q000494:pharmacology; D006968:Hypersensitivity, Delayed / Q000139:chemically induced* / Q000276:immunology; D007213:Indomethacin / Q000276:immunology / Q000494:pharmacology; D007978:Levamisole / Q000276:immunology / Q000494:pharmacology; D008297:Male; D010396:Penicillamine / Q000276:immunology / Q000494:pharmacology*; D010567:Pertussis Vaccine / Q000494:pharmacology*; D051381:Rats; D013045:Species Specificity; D013268:Stimulation, Chemical; D013997:Time Factors
D010567:Pertussis Vaccine; D007978:Levamisole; D005620:Freund's Adjuvant; D010396:Penicillamine; D007213:Indomethacin