Tolerance of rodent tails to necrosis after "daily" fractionated X rays or D-T neutrons.
The rat tail has been used as a model system to study the necrosis of an organized tissue following fractionated doses of collimated D-T neutrons or 290 kV X rays. RBE values for tail tolerance - 10 per cent of tails necrosing after the early skin reactions - rise from about 1-7 (single doses) to about 3-1 (16 fractions in 22 days). Neutron tolerance doses are almost independent of fractionation from 2 to 16 fractions. The tissues at risk are shown to be rather hypoxic. Early skin reaction levels can be used to predict the fraction of tails that will necrose. Early peak reactions for a given fraction of necrotic tails were slightly higher for neutrons than for X rays, and this difference was consistent for all the dose fractionation schedules employed.
D000818:Animals; D004307:Dose-Response Relationship, Radiation; D005214:Fast Neutrons; D005260:Female; D008297:Male; D051379:Mice; D009336:Necrosis; D010100:Oxygen / Q000494:pharmacology; D011829:Radiation Dosage; D011833:Radiation Injuries, Experimental; D051381:Rats; D012867:Skin / Q000528:radiation effects; D013623:Tail / Q000528:radiation effects*; D013696:Temperature; D013997:Time Factors; D014945:Wound Healing; D014965:X-Rays
D010100:Oxygen