Gastric secretory response to cholinergic stimulation in rats chronically pretreated with pentagastrin or histamine in depot form.
Rats pretreated by daily depot injections of pentagastric for 24 days, responded with a significant increase of gastric secretion volume, and HC1 concentration and output, when infused intravenously with bethanechol chloride. In these rats, the total weight of the stomach and the height of the fundic mucosa were also increased. Pretreatment with histamine had no effect on rat gastric tissue or gastric secretion, under identical conditions of stimulation.
D000818:Animals; D001626:Bethanechol Compounds / Q000494:pharmacology*; D003692:Delayed-Action Preparations; D004347:Drug Interactions; D005745:Gastric Acidity Determination; D005750:Gastric Juice / Q000378:metabolism*; D005753:Gastric Mucosa / Q000187:drug effects / Q000378:metabolism*; D006632:Histamine / Q000008:administration & dosage / Q000494:pharmacology*; D008297:Male; D009929:Organ Size / Q000187:drug effects; D010418:Pentagastrin / Q000008:administration & dosage / Q000494:pharmacology*; D051381:Rats; D011950:Receptors, Cholinergic / Q000187:drug effects*; D012636:Secretory Rate / Q000187:drug effects; D013270:Stomach / Q000187:drug effects
D001626:Bethanechol Compounds; D003692:Delayed-Action Preparations; D011950:Receptors, Cholinergic; D006632:Histamine; D010418:Pentagastrin