Carbohydrate and lipid metabolic studies before and after one year of treatment with ethynodiol diacetate in "normal" women.
A 3-hour oral glucose tolerance test was conducted in "normal" women before and after 12 months of contraceptive treatment with daily 0.25-mg ethynodiol diacetate tablets. There was no significant change in the subjects' weight between the two tests. All but the 3-hour individual group glucose values were significantly elevated at the 1-year test, and 16.7% of the tolerance curves became "borderline abnormal". The group plasma insulin values for the 0.5-, 1-, and 2-hour samples during the 1-year test were also significantly elevated. There was a significant decrease in the group fasting triglyceride levels but no change in the fasting cholesterol levels. These data suggest that some of the 19-norprogestogens may adversely affect carbohydrate metabolism.
D000328:Adult; D001786:Blood Glucose / Q000032:analysis; D002241:Carbohydrates / Q000097:blood*; D002784:Cholesterol / Q000097:blood; D005040:Ethynodiol Diacetate / Q000494:pharmacology*; D005260:Female; D006801:Humans; D007328:Insulin / Q000097:blood; D008055:Lipids / Q000097:blood*; D014280:Triglycerides / Q000097:blood
D001786:Blood Glucose; D002241:Carbohydrates; D007328:Insulin; D008055:Lipids; D014280:Triglycerides; D005040:Ethynodiol Diacetate; D002784:Cholesterol