Intraocular penetrating of amoxicillin.
The enucleated eyes of New Zealand albino rabbits were injected with 50, 100, 250, and 500 mg/kg of amoxicillin to determine the drug penetration into the aqueous humor, vitreous humor, serum, and other ocular tissues after oral administration. Detectable levels were achieved after each specific dose for at least five hours. In the aqueous humor, drug levels were present at 15 minutes, peaked at 1.5 and two hours, and were present at leave five hours after oral administration.
D000658:Amoxicillin / Q000097:blood / Q000378:metabolism*; D000667:Ampicillin / Q000031:analogs & derivatives*; D000818:Animals; D001082:Aqueous Humor / Q000378:metabolism; D005123:Eye / Q000378:metabolism*; D011817:Rabbits; D014822:Vitreous Body / Q000378:metabolism
D000667:Ampicillin; D000658:Amoxicillin