The molecular weight of aspermatogenic antigen as determined by equilibrium ultracentrifugation.
The extraction of antigen from testis and sperm is described. This antigen, when administered in microgram amounts in a single injection, induces aspermatogenesis in 100% of guinea pigs so treated. The deletion of the seminiferous cell line is specific (no cross-reactions) and provides a tool for investigating inhibition of cell replication as well as reproductive control. The antigen is a polypeptide-polysaccharide complex and has been determined to have a molecular weight of 10,520, using the equilibrium ultracentrifugation method.
D000818:Animals; D000941:Antigens; D002460:Cell Line; D006168:Guinea Pigs; D008297:Male; D008970:Molecular Weight; D012670:Seminiferous Epithelium / Q000276:immunology; D013091:Spermatogenesis; D014461:Ultracentrifugation
D000941:Antigens