Resistance of cold-exposed rats to aflatoxin.
Male rats kept at a temperature of 4 degrees-5 degrees C were refractory to a lethal dose of aflatoxin compared to animals at 20 degrees-21 degrees C which exhibited a high mortality and marked liver damage. It is suggested that this decreased susceptibility is mediated through a stimulated microsomal drug-metabolizing system in cold environment.
D000348:Aflatoxins / Q000494:pharmacology* / Q000633:toxicity; D000818:Animals; D003080:Cold Temperature; D004351:Drug Resistance; D008099:Liver / Q000033:anatomy & histology / Q000187:drug effects*; D008297:Male; D051381:Rats
D000348:Aflatoxins