Paget's osteitis deformans: a carbonate-rich calcium alkali phosphate in the pre-malignant bone mineral and implications for lymphoma production by CO2.
Comparison of powder diffraction patterns of unheated normal bone mineral with the damaged by Paget's Osteitis Deformans showed that due to a difference in the spacing of one weak inner reflection the possibility exists that carbonate-containing alpha-calcium sodium orthophosphate may be a minor constituent of the osteitic bone mineral. The chemical and physical properties of this substance make it a likely minor constituent of bone salt. The presence of this calcium alkali phosphate in the osteitic mineral was tentatively proposed after demonstrating the similarity of the diffraction patterns of synthetic mixtures of this substance with tricalcium phosphate hydrate to those of the osteitic bone salt.
D000368:Aged; D001842:Bone and Bones / Q000378:metabolism* / Q000473:pathology / Q000648:ultrastructure; D002118:Calcium / Q000378:metabolism; D002245:Carbon Dioxide; D002254:Carbonates / Q000378:metabolism*; D005260:Female; D006801:Humans; D008223:Lymphoma / Q000139:chemically induced / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D008968:Molecular Conformation; D010001:Osteitis Deformans / Q000378:metabolism* / Q000473:pathology; D010710:Phosphates / Q000378:metabolism*; D014961:X-Ray Diffraction
D002254:Carbonates; D010710:Phosphates; D002245:Carbon Dioxide; D002118:Calcium