The role of calcium in the negative inotropic effect of lanthanum.
Lanthanum reduces the rate of calcium fast exchanging processes, whereas the slowly exchanging phase is not modified. Experimental data also confirm the importance of calcium fast exchanging fraction in regulating contractile force of cardiac muscle.
D000818:Animals; D001692:Biological Transport / Q000187:drug effects; D002118:Calcium / Q000378:metabolism*; D006168:Guinea Pigs; D006325:Heart Atria; D066298:In Vitro Techniques; D007811:Lanthanum / Q000494:pharmacology*; D009200:Myocardial Contraction / Q000187:drug effects*; D009206:Myocardium / Q000378:metabolism*
D007811:Lanthanum; D002118:Calcium