title: Relative lipolytic activities of selected catecholamines in the mouse.
abstract: The adipokinetic activities, relative to isoproterenol as 1,000, in sedated, phenoxybenzamine pretreated unfasted mice were: norepinephrine 540, epinephrine 330, N-t-butylnorepinephrine 130, isoetharine 30 and N-cyclopentylbutanefrine 10. These relative activities correlate (r=0.88) with the medians of some previously defined beta1-adrenoceptor activities, but not (r=less than 0.1) with the medians of some previously defined beta2-adrenoceptor activities. These findings are in accord with the previously suggested view that an alpha, beta1-, beta2-, adrenoceptor concept is in better accord with experimental evidence that is an alpha- and beta-adrenoceptor one.
mesh_terms: D000605:Amino Alcohols / Q000494:pharmacology*; D000818:Animals; D004118:Dimethoxyphenylethylamine / Q000031:analogs & derivatives / Q000494:pharmacology; D007528:Isoetharine / Q000494:pharmacology*; D007545:Isoproterenol / Q000494:pharmacology*; D008053:Lipid Mobilization / Q000187:drug effects*; D008297:Male; D051379:Mice; D008771:Nordefrin / Q000031:analogs & derivatives; D009638:Norepinephrine / Q000031:analogs & derivatives / Q000494:pharmacology*; D011941:Receptors, Adrenergic / Q000187:drug effects
chemical_list: D000605:Amino Alcohols; D004118:Dimethoxyphenylethylamine; D011941:Receptors, Adrenergic; C000542:N-cyclopentylbutanephrine; C011595:colterol; D007545:Isoproterenol; D008771:Nordefrin; D009638:Norepinephrine; D007528:Isoetharine