title: [Experiment with rats on a 22-day flight on the "Kosmos-605" biological satellite (objectives and methods)].
abstract: In 1974 a rat experiment was carried out onboard the Cosmos-605 biosatellite. Inflight Wistar rats were kept unrestrained in small cages. The cages were equipped with a feeder, water supply, light source and a ventilation device. The state of the animals was assessed with respect to their motor activity. The flight experiment was preceded by a number of preparatory runs and testinns that were completed with an end-to-end experiment in a biosatellite mockup. The flight experiment was paralleled by the ground-based synchroneous experiment which simulated almost entirely the flight profile. For each experiment rats were selected and trained during a month's observation. Postflight rats were exposed to clinical, physiological, morphological, cytochemical and biochemical investigations. Tissue examinations were performed on the 2nd-3rd day (20 rats) and 26-27th day (12 rats) after flight. Four rats were kept to study remote aftereffects.
mesh_terms: D000222:Adaptation, Physiological; D000818:Animals; D001522:Behavior, Animal; D001773:Blood Cells; D001835:Body Weight; D004435:Eating; D008297:Male; D009043:Motor Activity; D009929:Organ Size; D051381:Rats; D013026:Space Flight; D013154:Spleen; D013950:Thymus Gland; D013997:Time Factors
vernacular_title: Eksperiment s krysami v 22-sutochnom polete na biologicheskom sputnike "Kosmos-605" (zadachi i metody)