Mechanisms of action of the antifertility agents U11, 100A and U11,555A in the rat.
Mature female rats were given U11,555A and U11,100A on orally on Day 2 of pregnancy and the number of implantations counted on Day 9. Using doses which reduced the implantation number to approximately 40% that of the controls, it was shown that the reduced number was not due to an effect on egg transport or to a delay of implantation.
D000818:Animals; D003281:Contraceptives, Postcoital / Q000494:pharmacology*; D003283:Contraceptives, Postcoital, Synthetic / Q000494:pharmacology*; D010064:Embryo Implantation / Q000187:drug effects*; D005260:Female; D007192:Indenes / Q000494:pharmacology*; D009256:Nafoxidine / Q000494:pharmacology*; D009929:Organ Size / Q000187:drug effects; D010066:Ovum Transport / Q000187:drug effects*; D011759:Pyrrolidines / Q000494:pharmacology*; D051381:Rats; D014599:Uterus / Q000187:drug effects
D003281:Contraceptives, Postcoital; D003283:Contraceptives, Postcoital, Synthetic; D007192:Indenes; D011759:Pyrrolidines; D009256:Nafoxidine