Modification of procine stress ulceration by methylprednisolone, vitaminA and methysergide treatment.
Using a swine shock ulcer model, three pharmacological agents, methylprednisolone, vitamin A and methysergide were evaluated, as they protect gastric mucosa against acute ulceration. Following haemorrhagic shock (3 h duration; mean arterial pressure 40 mm Hg) nine of the ten control animals (90%) developed gastric ulceration. Of the six test animals treated with intravenous methylprednisolone during the shock, only one (17%) developed gastric lesions (p less than 0.02; x2 = 5.76). Of the ten test animals pretreated with massive doses of parenteral vitamin A, only three (30%) developed lesions (p less than 0.05; x2 = 5.21). In contrast to this, treatment with methysergide, a serotonin antagonist, did not significantly effect the ulceration rate, since four of the six test animals (67%) had gastric lesions. The results suggest that methylprednisolone and vitamin A do protect the gastric mucosa from experiment stress ulceration, but their mechanism of action remain obscure and further investigation is needed to judge their value in clinical use.
D000818:Animals; D008775:Methylprednisolone / Q000627:therapeutic use*; D008784:Methysergide / Q000627:therapeutic use*; D012771:Shock, Hemorrhagic / Q000150:complications*; D013276:Stomach Ulcer / Q000209:etiology / Q000517:prevention & control*; D013552:Swine; D014801:Vitamin A / Q000627:therapeutic use*
D014801:Vitamin A; D008775:Methylprednisolone; D008784:Methysergide