Comparison of observed and predicted first-pass metabolism of nortriptyline in humans.
The extent of first-pass metabolism of nortriptyline, calculated by comparing the areas under the plasma concentration-time curves following intravenous and oral dosing in six individuals, varied from 41 to 54%. Theoretically predicted values ranged from 41 to 61% based on a plasma flow model, indicating that the clearance takes place mainly from the plasma, which does not represent the whole blood concentration.
D006801:Humans; D007700:Kinetics; D008954:Models, Biological; D009661:Nortriptyline / Q000097:blood / Q000378:metabolism*; D012039:Regional Blood Flow
D009661:Nortriptyline