L-Tryptophan administration in man: effects on gonadotrophin, growth hormone and cortisol secretion and on sexual motivation.
Long-lasting administration of L-tryptophan in neurologic patients caused a slight reduction of plasma luteinizing hormone levels without modifications of sexual motivation. Plasma follicle stimulating hormone concentrations were not altered by L-tryptophan. Short-lasting loading of L-tryptophan caused a statistically significant increase of plasma growth hormone levels, and a fall of plasma cortisol values in neurologic patients without neuroendocrine disorders. The pattern of plasma cortisol response to L-tryptophan loading was different in patients with neuroendocrine disorders. Plasma gonadotrophins seemed to be slightly reduced after the L-tryptophan loading.
D003864:Depression, Chemical; D005260:Female; D005640:Follicle Stimulating Hormone / Q000097:blood; D006062:Gonadotropins / Q000378:metabolism*; D013006:Growth Hormone / Q000378:metabolism*; D006801:Humans; D006854:Hydrocortisone / Q000378:metabolism*; D007986:Luteinizing Hormone / Q000097:blood; D008297:Male; D009042:Motivation; D012725:Sexual Behavior / Q000187:drug effects*; D013997:Time Factors; D014364:Tryptophan / Q000494:pharmacology*
D006062:Gonadotropins; D014364:Tryptophan; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone; D013006:Growth Hormone; D006854:Hydrocortisone