DNA damage produced by povidone-iodine in cultured human diploid cells.
Povidone-iodine is capable of selective altering the DNA of human diploid cells growing in culture. This finding extends to eukaryotic cells, the previously reported DNA-modifying activity of this agent for bacteria. In view of the known relationship between DNA-modifying activity and potential carcinogenicity, the results suggest that the potential hazards posed by the widespread use of this agent be evaluated.
D002478:Cells, Cultured; D002499:Centrifugation, Density Gradient; D004247:DNA / Q000032:analysis / Q000302:isolation & purification; D004171:Diploidy; D006801:Humans; D011205:Povidone / Q000031:analogs & derivatives*; D011206:Povidone-Iodine / Q000494:pharmacology*
D011206:Povidone-Iodine; D004247:DNA; D011205:Povidone