Chromosome aberrations in oocytes of NMRI mice and bone marrow cells of Chinese hamsters induced with 3,4-benzpyrene.
This paper deals with mutagenicity tests with 3,4-benzpyrene in mice oocytes of the strain NMRI and Chinese hamster bone-marrow cells. The mutagenic effect of this hydrocarbon was observed in both test systems. Investigations of bone-marrow chromosomes clearly show dose-response curves.
D000818:Animals; D001580:Benzopyrenes / Q000494:pharmacology*; D001853:Bone Marrow / Q000187:drug effects*; D001854:Bone Marrow Cells; D002869:Chromosome Aberrations; D006224:Cricetinae; D004305:Dose-Response Relationship, Drug; D005260:Female; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D009153:Mutagens; D009865:Oocytes / Q000187:drug effects*; D010063:Ovum / Q000187:drug effects*
D001580:Benzopyrenes; D009153:Mutagens