The effect of oxygen on the enzymes concerned in the metabolism of 5-hydroxytryptamine by rat brain and liver preparations.
1. The effect of oxygen concentration at 1 atm on rat enzyme systems concerned in the synthesis and degradation of 5-hydroxytryptamine was studied in vitro. 2. Oxygen activated tryptophan hydroxylase and the deamination of both 5-hydroxytryptamine and tyramine by monoamine oxidase. 3. Oxygen did not affect the activities of 5-hydroxytryptophan decarboxylase or peroxidase.
D000388:Air; D000818:Animals; D001921:Brain / Q000201:enzymology*; D004296:Dopa Decarboxylase / Q000378:metabolism; D005968:Glutamate Decarboxylase / Q000378:metabolism; D066298:In Vitro Techniques; D008099:Liver / Q000201:enzymology*; D008297:Male; D008995:Monoamine Oxidase / Q000378:metabolism; D010100:Oxygen / Q000494:pharmacology*; D010544:Peroxidases / Q000378:metabolism; D011506:Proteins / Q000378:metabolism; D051381:Rats; D012701:Serotonin / Q000378:metabolism*; D013268:Stimulation, Chemical; D014365:Tryptophan Hydroxylase / Q000378:metabolism
D011506:Proteins; D012701:Serotonin; D010544:Peroxidases; D014365:Tryptophan Hydroxylase; D008995:Monoamine Oxidase; D004296:Dopa Decarboxylase; D005968:Glutamate Decarboxylase; D010100:Oxygen