title: [Mosaic (Chimeric) animals: their experimental production and application (author's transl)].
abstract: A method introduced by Tarkowski permits the aggregation (mosaic-like fusion) of mammalian eggs in the early stages of division. In this paper, a modification of the Tarkowski method designed to create multiparental (mostly quadriparental) chimeric mice is discussed. The method described is simple, more practical and time-saving. The problems in analysing clonal processes of development in mammals and the mechanisms connected with sex differentiation and tumour development are discussed.
mesh_terms: D000818:Animals; D002678:Chimera; D002999:Clone Cells; D004622:Embryo, Mammalian; D005828:Genetics, Population; D005838:Genotype; D006824:Hybridization, Genetic; D051379:Mice; D009030:Mosaicism; D009369:Neoplasms / Q000235:genetics; D012733:Sex Differentiation
vernacular_title: Mosaikindividuen (Chimären): Experimentelle Herstellung und Verwendung