[Stimulation by the propranolol-glucagon test of somatotropin secretion in 71 children. Results, statistical study and comparison with the insulin-arginine test].
Two tests of stimulation: insulin + arginine and propranolol + glucagon were successively performed in 62 children who were either normal or had essential growth retardation. Average peak value was 10.6 +/- 1.1 ng/ml in the first test and 22.8 +/- 1.4 ng/ml in the second. In 56 cases the response obtained with propranolol + glucagon was higher than that obtained with insulin + arginine. Twenty-four false negative results were obtained employing insulin + arginine, stimulation by propranolol + glucagon resulting in normal values. The determination of the confidence interval at 95% and of the 3rd percentile did not allow to establish the lower threshold for the insulin + arginine test. For the propranolol + glucagon test 7.6 ng/ml for the interval at 95% and 8 ng/ml for 3rd percentile were found as minimal threshold. Therefore, a response below 8 ng/ml should be considered as pathological with the latter test.
D000293:Adolescent; D001120:Arginine; D002648:Child; D002675:Child, Preschool; D005260:Female; D005934:Glucagon; D006130:Growth Disorders / Q000175:diagnosis / Q000503:physiopathology*; D013006:Growth Hormone / Q000378:metabolism*; D006801:Humans; D007223:Infant; D007328:Insulin; D008297:Male; D010902:Pituitary Gland / Q000378:metabolism*; D010903:Pituitary Gland, Anterior / Q000378:metabolism*; D011433:Propranolol
D007328:Insulin; D013006:Growth Hormone; D005934:Glucagon; D001120:Arginine; D011433:Propranolol
Stimulation par le test propranolol--glucagon de la secretion somatotrope chez 71 enfants. Resultats. etude statistique et comparaison avec le test insuline-arginine