title: Allosteric linkage and phase transition.
abstract: The thermodynamics of allosteric linkage are observed to be analogous to those of a phase transition. When a phenomenological theory of phase transitions is applied to the allosteric interactions in hemoglobin, a generalized Hill equation is arrived at, including an explicit dependence on temperature. This result is in good agreement with experiments.
mesh_terms: D000494:Allosteric Regulation; D000818:Animals; D001669:Biochemical Phenomena; D001671:Biochemistry; D006454:Hemoglobins; D007700:Kinetics; D008433:Mathematics; D010100:Oxygen / Q000097:blood; D013696:Temperature; D013816:Thermodynamics
chemical_list: D006454:Hemoglobins; D010100:Oxygen