Genetic lipoprotein variation and lipid levels in man.
Analyses of 12 population samples have revealed that the total serum cholesterol level is significantly higher in Lp(a +) than in Lp(a -) individuals. The difference is more pronounced in middle-aged and other people than in young persons, and the difference between Lp(a +) and Lp(a -) individuals is larger when LDL cholesterol rather than total serum cholesterol is considered. Lp(a -) individuals have a significantly higher triglyceride level than Lp(a +) individuals. The Lp(a) variation is genetically controlled. Thus, the present study has revealed a small but significant effect of a single, autosomal locus on lipids implicated in atherosclerosis. An association between the phenotype Lp(a +) and coronary heart disease has been demonstrated previously.
D000293:Adolescent; D000328:Adult; D000368:Aged; D001161:Arteriosclerosis / Q000209:etiology / Q000235:genetics; D002784:Cholesterol / Q000097:blood; D003327:Coronary Disease / Q000209:etiology / Q000235:genetics; D005260:Female; D014644:Genetic Variation; D006801:Humans; D008074:Lipoproteins / Q000097:blood*; D008297:Male; D008875:Middle Aged; D010641:Phenotype; D014280:Triglycerides / Q000097:blood
D008074:Lipoproteins; D014280:Triglycerides; D002784:Cholesterol