title: Persistence of a basal lamina-like structure following DOCA-induced myofibrillar degeneration in rats.
abstract: It is known that the myocardial necrosis of potassium depletion heals by reconstitution and not by scarring, when animals are replenished with potassium. In the course of studies on DOCA-induced myofibrillar degeneration, we found that a membrane-like structure persisted in the area where the disintegrating myofiber was being removed by macrophages. This structure resembled the basal lamina, and enclosed a space in which macrophages with phagosomes containing disintegrating myofibral constituents were seen in association with undifferentiated cells. We postulate that this basal lamina-like structure along with the undifferentiated cells, play a role in the reconstitution of the myocardium during the stage of potassium repletion, and that the scaffolding by basal lamina may be effective in myocardial reconstitution.
mesh_terms: D000818:Animals; D009202:Cardiomyopathies / Q000139:chemically induced / Q000473:pathology*; D003900:Desoxycorticosterone; D008264:Macrophages / Q000648:ultrastructure; D008297:Male; D009206:Myocardium / Q000378:metabolism / Q000648:ultrastructure*; D009210:Myofibrils / Q000187:drug effects / Q000648:ultrastructure*; D011188:Potassium / Q000378:metabolism; D011191:Potassium Deficiency / Q000139:chemically induced / Q000473:pathology*; D051381:Rats
chemical_list: D003900:Desoxycorticosterone; D011188:Potassium