Effects of apomorphine and of pimozide on renin secretion in the anaesthetized dog.
This paper presents the results of a study of the receptors involved in renin hypersecretion induced by dopamine. Apomorphine induces renin hypersecretion without significantly modifying the renal blood flow. This renin hypersecretion is inhibited by haloperidol. However, pimozide, a selective dopaminolytic agent, is incapable of inhibiting the renin hypersecretion induced by dopamine. These results provide supplementary evidence for the existence of renal dopaminergic receptors which would appear to differ from the central dopaminergic receptors.
D000818:Animals; D001058:Apomorphine / Q000494:pharmacology*; D004285:Dogs; D004298:Dopamine / Q000494:pharmacology; D004347:Drug Interactions; D006220:Haloperidol / Q000494:pharmacology; D007668:Kidney / Q000187:drug effects; D010868:Pimozide / Q000494:pharmacology*; D012083:Renin / Q000378:metabolism*; D013997:Time Factors
D010868:Pimozide; D012083:Renin; D006220:Haloperidol; D001058:Apomorphine; D004298:Dopamine