Modification by diazepam or thioridazine of the psychomotor skills related to driving: a subacute trial in neurotic out-patients.
Forty-five out-patients with clinically manifested anxiety were tested in order to study the effects of 2 weeks' treatment with placebo, diazepam (5-10 mg three times daily) or thioridazine (25-50 mg three times daily) on their psychomotor skills related to driving. When compared with placebo, diazepam increased the number of mistakes in reaction and co-ordination tests and also decreased ability to discriminate the fusion of flickering light. When compared to other groups, reactive and co-ordinative skills were more impaired in patients treated with thioridazine which also impaired divided attention. Aubjectively thioridazine was not experienced as effective an anxiolytic as diazepam.
D000328:Adult; D000553:Ambulatory Care; D001008:Anxiety Disorders / Q000188:drug therapy*; D001288:Attention / Q000187:drug effects; D001334:Automobile Driving; D003975:Diazepam / Q000097:blood / Q000494:pharmacology*; D005260:Female; D006801:Humans; D008297:Male; D009048:Motor Skills / Q000187:drug effects*; D010919:Placebos; D011930:Reaction Time / Q000187:drug effects; D013881:Thioridazine / Q000097:blood / Q000494:pharmacology*; D014796:Visual Perception / Q000187:drug effects
D010919:Placebos; D013881:Thioridazine; D003975:Diazepam