title: A.E. Bennett Award Paper. A kinetic analysis of 5-hydroxyindoleacetic acid excretion from rat brain and csf.
abstract: Studies of neurotransmitter kinetics based on intraventricular injections of radio-labeled metabolites have been limited by several problems, including the inability of most investigators to recover more than 45% of the infected isotope from brain homogenates within several minutes after the injection...
mesh_terms: D000418:Albumins / Q000378:metabolism; D000818:Animals; D001693:Biological Transport, Active / Q000187:drug effects; D001812:Blood-Brain Barrier; D001921:Brain / Q000378:metabolism*; D001923:Brain Chemistry; D002552:Cerebral Ventricles / Q000033:anatomy & histology / Q000378:metabolism; D002946:Cisterna Magna / Q000033:anatomy & histology; D006897:Hydroxyindoleacetic Acid / Q000097:blood / Q000134:cerebrospinal fluid / Q000378:metabolism*; D007444:Inulin / Q000134:cerebrospinal fluid / Q000378:metabolism; D007700:Kinetics; D008297:Male; D008954:Models, Biological; D011339:Probenecid / Q000494:pharmacology; D051381:Rats; D013346:Subarachnoid Space / Q000378:metabolism
chemical_list: D000418:Albumins; D006897:Hydroxyindoleacetic Acid; D007444:Inulin; D011339:Probenecid