Effects of drugs modifying brain levels of catecholamines on photically induced epilepsy in Papio papio.
The behavioral and electrographic effects of DL-amphetamine, disulfiram, FLA-63, and propranolol on the photically induced epilepsy of the Senegalese baboon were evaluated. Amphetamine produced somatic hypokinesia with enhancement of eye movements, diminution of spontaneous paroxysmal activity, and little change in photosensitivity. The acute effects of disulfiram and FLA-63 were poor, but the latter was lethal in the days following administration. Propranolol showed no consistent effects. Participation of catecholamine processes in this type of experimental reflex epilepsy are discussed.
D000661:Amphetamine / Q000494:pharmacology; D000818:Animals; D005406:Bis(4-Methyl-1-Homopiperazinylthiocarbonyl)disulfide / Q000494:pharmacology; D001921:Brain / Q000187:drug effects / Q000378:metabolism*; D002395:Catecholamines / Q000378:metabolism*; D004221:Disulfiram / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D004569:Electroencephalography; D004827:Epilepsy / Q000188:drug therapy / Q000209:etiology / Q000378:metabolism*; D005133:Eye Movements / Q000187:drug effects; D008027:Light; D010215:Papio; D011433:Propranolol / Q000494:pharmacology
D002395:Catecholamines; D005406:Bis(4-Methyl-1-Homopiperazinylthiocarbonyl)disulfide; D011433:Propranolol; D000661:Amphetamine; D004221:Disulfiram