title: Lung morphology in experimental uremia.
abstract: The investigations were performed on 15 dogs with experimental uremia, but free of overhydration and circulatory insufficiency. Parahilar lungs areas showed numerous atelectatic foci, the peripheral part--conpensatory marginal emphusema. Light microscopy revealed a decreased number of granular cells, electron microscopy the "empty" appearance of the lamellar structures, and decrease or absence of the Hale-positive layer of alveolar lining film. The inhibition of cells controlling the alveolar surgace tension seems to be crucial in the pathomechanism of development of uremic lung lesions.
mesh_terms: D000818:Animals; D004285:Dogs; D008168:Lung / Q000473:pathology*; D008854:Microscopy, Electron; D001261:Pulmonary Atelectasis / Q000209:etiology / Q000473:pathology; D011654:Pulmonary Edema / Q000209:etiology / Q000473:pathology; D011656:Pulmonary Emphysema / Q000209:etiology / Q000473:pathology; D014511:Uremia / Q000150:complications / Q000473:pathology*