Influence of training on myocardial responses of rats subjected to conditions of ischaemia and hypoxia.
Physical training has been advocated to minimize the problems associated with coronary heart disease; however, the responsible mechanisms are obscure. Rats trained to run on a treadmill were subjected to acute conditions of hypoxia and myocardial ischaemia. Trained rats were better able to maintain a higher level of cardiac performance (dP/dt max) after hypoxia than non-trained rats, but no advantages were apparent after ischaemia. Biochemical data showed no myocardial differences between the groups in oxygen utilization or energy availability.
D000255:Adenosine Triphosphate / Q000378:metabolism; D000818:Animals; D001794:Blood Pressure; D003327:Coronary Disease / Q000378:metabolism / Q000503:physiopathology*; D006321:Heart / Q000503:physiopathology*; D006339:Heart Rate; D000860:Hypoxia / Q000378:metabolism / Q000503:physiopathology*; D007773:Lactates / Q000378:metabolism; D008297:Male; D008931:Mitochondria, Muscle / Q000378:metabolism; D009206:Myocardium / Q000378:metabolism*; D010725:Phosphocreatine / Q000378:metabolism; D010805:Physical Conditioning, Animal; D051381:Rats
D007773:Lactates; D010725:Phosphocreatine; D000255:Adenosine Triphosphate