title: Renal function, protein binding and pharmacological response to diazoxide.
abstract: 1 The effect of rapid (10s) injections of diazoxide was studied in ten hypertensive patients with varying degrees of impairment of renal function. 2 There was a significant correlation between the patient's plasma urea concentration and reduction in mean arterial blood pressure. Diazoxide was also shown to be less highly protein bound in patients with renal failure. 3 It is suggested that the explanation for the increased hypotensive effect of diazoxide observed in patients with reduced renal function is related to higher unbound drug concentrations.
mesh_terms: D000328:Adult; D001794:Blood Pressure / Q000187:drug effects; D003981:Diazoxide / Q000097:blood / Q000494:pharmacology* / Q000627:therapeutic use; D005260:Female; D006801:Humans; D006973:Hypertension / Q000188:drug therapy; D007676:Kidney Failure, Chronic / Q000097:blood / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged; D011485:Protein Binding; D006435:Renal Dialysis
chemical_list: D003981:Diazoxide