title: PGE2: opposite effect on catecholamine release from phaeochromocytoma and adrenal medulla.
abstract: The effect of PGE2 on catecholamine release from human adrenal medulla and phaechromocytoma was studied in slices incubated in vitro. In each of 3 normal human adrenal medullae PGE2 (10(-7) M) caused a significant inhibition of the release of catecholamines in in vitro incubation. In each of 3 phaechromocytomas studied PGE2 (10(-7) M) caused a significant increase of catecholamine release in in-vitro incubation. The possible relevance of this mechanism to the regulation of catecholamine release in phaeochromocytoma is discussed.
mesh_terms: D000293:Adolescent; D000310:Adrenal Gland Neoplasms / Q000378:metabolism*; D000313:Adrenal Medulla / Q000378:metabolism*; D000328:Adult; D002395:Catecholamines / Q000378:metabolism*; D005260:Female; D006801:Humans; D066298:In Vitro Techniques; D008297:Male; D008875:Middle Aged; D010673:Pheochromocytoma / Q000378:metabolism*; D011458:Prostaglandins E / Q000494:pharmacology*; D012636:Secretory Rate / Q000187:drug effects
chemical_list: D002395:Catecholamines; D011458:Prostaglandins E