The significance of serum oestradiol and progesterone levels in evaluating the response to clomiphene citrate.
In practice, the prediction of ovulation after the administration of clomiphene citrate (Clomid) has been based on measurement of biphasic basal body temperature and menstrual changes. In this article a protocol is presented to gauge adequately the extent of the response to the drug and to monitor reliably the occurrence of ovulation. The measurement of oestradiol levels at two different times, coupled with a single progesterone estimation, has proved the method of choice in monitoring Clomid response. These assays may provide reliable criteria for establishing suitable doses for individual patients.
D000293:Adolescent; D000328:Adult; D000568:Amenorrhea / Q000097:blood / Q000188:drug therapy; D000858:Anovulation / Q000097:blood / Q000188:drug therapy; D002996:Clomiphene / Q000494:pharmacology* / Q000627:therapeutic use; D004958:Estradiol / Q000097:blood*; D005260:Female; D006801:Humans; D010060:Ovulation / Q000187:drug effects*; D010061:Ovulation Detection / Q000379:methods; D011374:Progesterone / Q000097:blood*
D002996:Clomiphene; D011374:Progesterone; D004958:Estradiol