[Influence of uncoupling agents on the capacity of transamidinase in kidney and pancreas].
It was found in white rats that hyperthyreosis (0.5% thyreoidin in dry food), respectively 2,4-dinitrophenol (30 mg/kg body weight/day i. p.), deficiency of the vitamins K and E or complete fasting increase the content of creatine in muscle, plasma and urine, but reduce the concentration of creatinine. Simultaneously the elevated creatine level of blood causes a repression of transamidinase in kidneys and pancreas. The common mode of action of the mentioned agents is seen in a decoupling of the oxidative phosphorylation, and in an insufficient availability of ATP, respectively.
D000255:Adenosine Triphosphate / Q000378:metabolism; D000579:Amidinotransferases / Q000378:metabolism*; D000818:Animals; D003401:Creatine / Q000378:metabolism; D003404:Creatinine / Q000378:metabolism; D004140:Dinitrophenols / Q000494:pharmacology; D005215:Fasting; D006980:Hyperthyroidism / Q000201:enzymology; D007668:Kidney / Q000187:drug effects / Q000201:enzymology*; D010085:Oxidative Phosphorylation / Q000187:drug effects; D010179:Pancreas / Q000187:drug effects / Q000201:enzymology*; D051381:Rats; D014475:Uncoupling Agents / Q000494:pharmacology*; D014811:Vitamin E Deficiency / Q000201:enzymology; D014813:Vitamin K Deficiency / Q000201:enzymology
D004140:Dinitrophenols; D014475:Uncoupling Agents; D000255:Adenosine Triphosphate; D003404:Creatinine; D000579:Amidinotransferases; D003401:Creatine
Einfluss entkoppelnder Agentien auf die Transamidinase-Kapazität von Nieren und Pankreas