title: Variations in rat liver chromatin composition during growth and the heterotic response.
abstract: The manifestation of hybrid vigor with regard to the inheritance of body weight was established as a postweaning phenomenon in rats. Liver weight gain generally corresponded to body weight gain and also reflected hybrid vigor. The protein/DNA ratios of the chromatin from livers of inbred and heterotic hybrid male rats were found to increase with increasing age in growing rats. Hybrid chromatin had higher protein/DNA ratios throughout the age range studies. The difference between hybrids and inbreds were greatest in the early postweaning stages of growth and maturation. The RNA/DNA ratios of chromatin from livers of inbred and hybrid male rats were also found to exhibit trends within certain developmental periods.
mesh_terms: D000375:Aging; D000818:Animals; D002843:Chromatin / Q000378:metabolism*; D004247:DNA / Q000378:metabolism; D005260:Female; D006823:Hybrid Vigor; D008099:Liver / Q000254:growth & development / Q000378:metabolism*; D008297:Male; D009698:Nucleoproteins / Q000378:metabolism; D009929:Organ Size; D012313:RNA / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains
chemical_list: D002843:Chromatin; D009698:Nucleoproteins; D012313:RNA; D004247:DNA