Effect of dantrolene sodium upon the activity of the hind leg muscle of the cat with local tetanus.
Cats with local tetanus were i.v. injected with dantrolene sodium. There is no effect of dantrolene sodium on the electromyogram in response to indirect stimulation of the non-poisoned muscle nor on the increased spontaneous activity of the poisoned muscle. The tension of the muscle, however, was strongly reduced.
D000200:Action Potentials / Q000187:drug effects; D000818:Animals; D002415:Cats; D003620:Dantrolene / Q000494:pharmacology*; D006614:Hindlimb; D006827:Hydantoins / Q000494:pharmacology*; D009046:Motor Neurons / Q000187:drug effects; D009119:Muscle Contraction / Q000187:drug effects*; D013742:Tetanus / Q000503:physiopathology*; D013744:Tetanus Toxin
D006827:Hydantoins; D013744:Tetanus Toxin; D003620:Dantrolene