title: Disseminated superficial actinic porokeratosis. Analysis of an affected family.
abstract: A family is analysed in which disseminated superficial actinic porokeratosis (DSAP) occurred in five members. All three children of one generation are affected. Clinical, histopathological and genetic aspects of DSAP are discussed. Disseminated superficial actinic porokeratosis appears to be a clinical variant of porokeratosis of Mibelli. Since DSAP is a genodermatosis inherited as an autosomal dominant it can occur in any geographical location; however excess sunlight can definitely exacerbate the condition.
mesh_terms: D000328:Adult; D000368:Aged; D001132:Arm; D004890:Erythema / Q000235:genetics; D005260:Female; D005533:Foot Dermatoses / Q000235:genetics; D006229:Hand Dermatoses / Q000235:genetics; D006801:Humans; D007642:Keratosis / Q000235:genetics* / Q000473:pathology; D007866:Leg; D008297:Male; D009333:Neck; D010375:Pedigree; D011537:Pruritus / Q000235:genetics; D013472:Sunlight; D013577:Syndrome