The morphologic similarities of human and canine globoid leukodystrophy. Thin section and freeze-fracture studies.
Human and canine globoid leukodystrophy are shown to be indistinguishable morphologically. Both have characteristic deposits with polygonal cross-sectional profiles in addition to twisted ribbon-like structures. The specificity of the deposits is emphasized, and their laminated nature is corroborated by the freeze-fracture studies. Their apparently hollow profiles in cross section are thought to be produced by the tight arrangement of the bilayers that prevent penetration of the stain.
D000818:Animals; D001344:Autopsy; D001921:Brain / Q000473:pathology* / Q000648:ultrastructure; D003593:Cytoplasm / Q000648:ultrastructure; D004283:Dog Diseases / Q000473:pathology*; D004285:Dogs; D005260:Female; D005614:Freeze Fracturing; D006801:Humans; D007223:Infant; D007965:Leukodystrophy, Globoid Cell / Q000473:pathology* / Q000662:veterinary; D008297:Male; D009940:Organoids / Q000648:ultrastructure