Chronic ulcerative colitis, skin necrosis, and cryofibrinogenemia.
Necrotizing skin lesions developed in a man with chronic ulcerative colitis. No evidence of intrinsic disease of medium or small-sized vessels was found. A circulating cryofibrinogen was thought to be responsible for in situ thrombosis leading to skin infarctions. Sodium warfarin in a daily dose of 2.5 to 5 mg appears to have thwarted progression of developing lesions and the occurrence of new ones.
D001796:Blood Protein Disorders / Q000150:complications*; D002908:Chronic Disease; D003080:Cold Temperature; D003093:Colitis, Ulcerative / Q000150:complications*; D005340:Fibrinogen; D006801:Humans; D008297:Male; D008875:Middle Aged; D009336:Necrosis; D012871:Skin Diseases / Q000188:drug therapy / Q000209:etiology* / Q000473:pathology; D014859:Warfarin / Q000627:therapeutic use
D014859:Warfarin; D005340:Fibrinogen