Quality assurance for 99mTc-Sn-pyrophosphate.
Because skeletal images obtained with a commercial lyophilized preparation of 99mTc-Sn-pyrophosphate were occasionally degraded by liver and spleen uptake, a method for preparing 99mTc-Sn-pyrophosphate and a system for in-house quality assurance were developed. Control of the age of the stannous chloride solution and the final pH of the 99mTc-Sn-pyrophosphate eliminated the undesirable uptake. The quality and body distribution of the in-house preparation were compared to those of the radiopharmaceutical from a commercial kit.
D000818:Animals; D004285:Dogs; D011786:Quality Control; D011817:Rabbits; D013667:Technetium
D013667:Technetium