Acute inhalation toxicity of cotton plant dusts.
The number of free lung-cells was studied in guinea-pigs after acute exposure to extracts of various cotton dusts. A good correlation was found between the increase in number of leucocytes in the airways and the number of Gram-negative bacteria in the different dusts. Experiments using the Shwartzmann reaction and the Limulus titration test demonstrated a relationship between the content of different endotoxins in the dusts and the pulmonary reaction. A model for the acute exposure effects after exposure to cotton dust is proposed.
D000818:Animals; D004391:Dust / Q000032:analysis*; D004731:Endotoxins / Q000032:analysis; D003368:Gossypium; D006088:Gram-Negative Aerobic Bacteria; D006168:Guinea Pigs; D007958:Leukocyte Count; D008168:Lung / Q000166:cytology; D008264:Macrophages; D008954:Models, Biological
D004391:Dust; D004731:Endotoxins