title: Vagal influence on serotonin concentration in enterochromaffin cells in the cat.
abstract: The intracellular concentrations of 5-HT in enterochromaffin cells of the jejunum, midgut and ileum of the cat have been estimated by a cytofluorimetric method before and after various periods of peripheral vagal nerve stimulation. The fluorescence intensities in randomized cell samples were measured photometrically after a standard illumination time before and after nerve stimulation. A significant decrease in 5-HT concentration in the enterochromaffin cells all through the small intestine could be demonstrated, which is in support of the hypothesis of a neurogenic release of 5-HT from enterochromaffin cells, possibly caused by vagal adrenergic fibres.
mesh_terms: D000818:Animals; D002415:Cats; D002838:Chromaffin System / Q000378:metabolism*; D004558:Electric Stimulation; D004759:Enterochromaffin Cells / Q000378:metabolism*; D005260:Female; D005470:Fluorometry; D006651:Histocytochemistry; D007082:Ileum / Q000378:metabolism; D007421:Intestine, Small / Q000378:metabolism*; D007583:Jejunum / Q000378:metabolism; D008297:Male; D012701:Serotonin / Q000378:metabolism*; D013997:Time Factors; D014630:Vagus Nerve / Q000502:physiology*
chemical_list: D012701:Serotonin