Free phenols in chronic renal failure.
Serum total free phenols are elevated in chronic renal failure, acute renal failure and hepatic coma. Being partly protein-bound, phenols behave during dialysis in a similar manner to considerably larger molecules which are not protein-bound. In view of their potential toxicity they should be considered as an alternative to 'middle molecules'. Patients on regular hemodialysis have retention of phenols if their post-dialysis serum creatinine is above 6-7 mg/dl. Patients on short time dialysis have high pre-dialysis neutral phenol levels. Such levels are sufficiently high to suggest a role in the genesis of neurological symptoms, anemia and bone disease. Certainly pre-dialysis free phenols reflect adequacy of dialysis.
D058186:Acute Kidney Injury / Q000097:blood; D003404:Creatinine / Q000097:blood; D006501:Hepatic Encephalopathy / Q000097:blood; D006801:Humans; D007676:Kidney Failure, Chronic / Q000097:blood* / Q000628:therapy; D010636:Phenols / Q000097:blood*; D006435:Renal Dialysis; D013997:Time Factors
D010636:Phenols; D003404:Creatinine