Malignant histiocytosis: complete remission with combination chemotherapy.
A case of a 16-year-old girl with malignant histiocytosis involving the lymph nodes, bone marrow, peripheral blood, liver, and spleen is described. This patient achieved a complete remission with cyclic quadruple chemotherapy consisting of cyclophosphamide, vincristine, procarbazine, and prednisone (COPP). She is alive and free of disease more than 4 years after the completion of COPP and after having had maintenance treatment with a small dose of cyclophosphamide for 2 3/4 years. Such good results with the COPP regimen in malignant histiocytosis have not been reported previously, and it is suggested that this modality of treatment warrants further trial.
D000293:Adolescent; D003520:Cyclophosphamide / Q000008:administration & dosage*; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D008206:Lymphatic Diseases / Q000188:drug therapy* / Q000473:pathology; D011241:Prednisone / Q000008:administration & dosage*; D011344:Procarbazine / Q000008:administration & dosage*; D012075:Remission, Spontaneous; D014750:Vincristine / Q000008:administration & dosage*
D011344:Procarbazine; D014750:Vincristine; D003520:Cyclophosphamide; D011241:Prednisone