A preliminary report on the antiarrhythmic action of some newly synthesized glutarimide compounds.
The effects of a new series of glutarimide compounds have been studied in acetylcholine induced auricular fibrillation in anaesthetized cats and epinephrine induced ventricular arrhythmmias in conscious pigeons. Some of the compounds showed varying degree of protective action against experimental arrhythmias. However these compounds were found to be less potent than quinidine. The mechanism of antiarrhythmic action has been discussed.
D000109:Acetylcholine; D000772:Anesthesia, Local; D000818:Animals; D000889:Anti-Arrhythmia Agents / Q000627:therapeutic use*; D001281:Atrial Fibrillation / Q000139:chemically induced / Q000188:drug therapy; D002415:Cats; D010856:Columbidae; D004837:Epinephrine; D005260:Female; D006168:Guinea Pigs; D007094:Imides / Q000627:therapeutic use; D008297:Male; D010880:Piperidines / Q000627:therapeutic use*; D010881:Piperidones / Q000627:therapeutic use*; D011817:Rabbits; D014693:Ventricular Fibrillation / Q000139:chemically induced / Q000188:drug therapy
D000889:Anti-Arrhythmia Agents; D007094:Imides; D010880:Piperidines; D010881:Piperidones; C007864:glutarimide; D000109:Acetylcholine; D004837:Epinephrine