Gas chromatographic trace analysis of beta-propiolactone in sterilized serum proteins.
A method for detecting traces of beta-propiolactone, which was previously described by Schmitz-Masse, has been modified and adapted to the analysis of protein solutions. Using this method, the rate of hydrolysis of beta-propiolactone (beta-P1) was examined and beta-P1 sterilized commercial products were analyzed for possible residual nonhydrolyzed beta-P1.
D001798:Blood Proteins / Q000032:analysis; D002849:Chromatography, Gas; D006801:Humans; D006868:Hydrolysis; D007136:Immunoglobulins / Q000032:analysis*; D007783:Lactones / Q000097:blood*; D011420:Propiolactone / Q000097:blood*; D012996:Solutions; D013242:Sterilization
D001798:Blood Proteins; D007136:Immunoglobulins; D007783:Lactones; D012996:Solutions; D011420:Propiolactone