title: Splenic artery ligation in experimental hypersplenism.
abstract: The effects of splenic artery ligation (SAL) were examined in Sprague-Dawley rats with methyl-cellulose-induced hypersplenism. When performed close to the splenic hilium, SAL effectively reduced functioning splenic mass and raised peripheral counts of leukocytes and platelets, a response similar to that following total splenectomy. In hypersplenism, therefore, a satisfactory hematologic response may not necessary require total ablation of the spleen but merely substantial reduction of functioning splenic tissue.
mesh_terms: D000818:Animals; D001772:Blood Cell Count; D001792:Blood Platelets; D001835:Body Weight; D006400:Hematocrit; D006971:Hypersplenism / Q000097:blood / Q000139:chemically induced / Q000601:surgery*; D007958:Leukocyte Count; D008026:Ligation; D008297:Male; D008747:Methylcellulose; D051381:Rats; D013156:Splenectomy; D013157:Splenic Artery / Q000601:surgery*
chemical_list: D008747:Methylcellulose