In vivo dopamine release and prostaglandin E2.
Cerebroventricular perfusion of cats pretreated with H3-dopamine was used to monitor the neuronal release of dopamine. Infusion of prostaglandin E2 (PGE2, 10-6M) has no effect upon this release. Electrical stimulation in the region of the ascending dopamine containing fibers in the lateral hypothalamus results in a marked increase in H3-dopamine release. Infusion of PGE2 during electrical stimulation does not alter this release either in the presence of normal (1.16 mM) or elevated (7.5 mM) Ca++. Under the conditions of these experiments, PGE2 does not modulate dopamine release to any measureable degree.
D000818:Animals; D002118:Calcium / Q000494:pharmacology; D002415:Cats; D004298:Dopamine / Q000378:metabolism*; D004558:Electric Stimulation; D005260:Female; D007031:Hypothalamus / Q000502:physiology; D008297:Male; D011458:Prostaglandins E / Q000494:pharmacology*; D013569:Synapses / Q000187:drug effects / Q000378:metabolism
D011458:Prostaglandins E; D002118:Calcium; D004298:Dopamine