Serum cortisol and 11-desoxycortisol levels in hirsute premenopausal women.
It has been postulated that hirsute patients may have a relative deficiency in 11beta-hydroxylase activity of the adrenal cortex. In order to test this postulate, we have measured the serum levels of cortisol (Cp F) and 11-desoxycortisol (Cp S) and estimated the Cp S/Cp F ratio in 9 nonhirsute and 34 hirsute premenopausal women. As a group, the hirsute patients had significantly elevated (P less than 0.05) mean Cp F and Cp S levels but the mean Cp S/Cp F ratio was not significantly different from normal. Considered individually, only 3 hirsute patients had a Cp S/Cp F ratio greater than 2 SD above the mean normal levels. These ratios were 0.0218, 0.0139, and 0.023. If there is indeed an 11beta-hydroxylase deficiency in these 3 patients, it must be relatively minor, since a patient with documented 11beta-hydroxylase deficiency had Cp S levels of 218 ng/ml and a Cp S/Cp F ratio of 0.7. Our data suggest that 11beta-hydroxylase deficiency is not a common cause of hirsutism.
D015065:17-Hydroxycorticosteroids / Q000097:blood*; D000328:Adult; D002845:Chromatography / Q000379:methods; D003350:Cortodoxone / Q000097:blood*; D005260:Female; D006628:Hirsutism / Q000097:blood*; D006801:Humans; D006854:Hydrocortisone / Q000097:blood*; D008297:Male; D008797:Metyrapone / Q000494:pharmacology; D006899:Mixed Function Oxygenases / Q000172:deficiency; D011863:Radioimmunoassay
D015065:17-Hydroxycorticosteroids; D006899:Mixed Function Oxygenases; D003350:Cortodoxone; D006854:Hydrocortisone; D008797:Metyrapone