title: Cell surface immunoglobulin. XV. The presence of IgM and an IgD-like molecule on the same cell in murine lymphoid tissue.
abstract: The present studies were designed to determine whether IgM and "IgD" are on the same cell in the mouse. Thus, radioiodinated murine lymphocytes were treated with anti-mu and complement to kill IgM-bearing cells. The dead cells were removed by gradient centrifugation. Results indicate that a portion of the IgD is removed by depleting IgM-bearing cells. Using cells from thoracic duct or lymph nodes but not spleen, it was evident that some of the double bearers are large lymphocytes.
mesh_terms: D000818:Animals; D007072:Immunoglobulin D / Q000032:analysis*; D007075:Immunoglobulin M / Q000032:analysis*; D008198:Lymph Nodes / Q000276:immunology; D051379:Mice; D008805:Mice, Inbred A; D011947:Receptors, Antigen, B-Cell / Q000032:analysis*; D013154:Spleen / Q000276:immunology
chemical_list: D007072:Immunoglobulin D; D007075:Immunoglobulin M; D011947:Receptors, Antigen, B-Cell