Antibody-induced killing in vivo of L1210/MTX-R cells quantitated in passively immunized mice with 131I-iododeoxyuridine-labeled cells and whole-body measurement of retained radioactivity.
The killing of the LR subline of the DBA/2J leukemia L1210/MTX by passive antibody was followed in vivo with 131I-iododeoxyuridine-labeled cells and whole-body measurement of retained radioactivity. The in vivo killing of LR cells was proportional to the in vitro 2-mercaptoethanol resistant titer, independent of the complement system, and radioresistant. Although a large percentage of the leukemic cells was killed in passively immunized mice, the protective effect of the passive antiserum was dependent on the active immune response of the host.
D000818:Animals; D000912:Antibodies, Neoplasm / Q000008:administration & dosage; D002470:Cell Survival; D003165:Complement System Proteins / Q000378:metabolism; D003601:Cytotoxicity Tests, Immunologic; D005260:Female; D007065:Idoxuridine; D007110:Immunity, Active / Q000528:radiation effects; D007116:Immunization, Passive; D007074:Immunoglobulin G; D007075:Immunoglobulin M; D007167:Immunotherapy; D007700:Kinetics; D007939:Leukemia L1210 / Q000276:immunology* / Q000628:therapy; D008623:Mercaptoethanol; D051379:Mice; D011830:Radiation Effects
D000912:Antibodies, Neoplasm; D007074:Immunoglobulin G; D007075:Immunoglobulin M; D008623:Mercaptoethanol; D003165:Complement System Proteins; D007065:Idoxuridine