Bacteriocin (klebocin) sensitivity typing of klebsiella.
High-titer preparations of Klebsiella bacteriocins (klebocins) were obtained by using mitomycin to induce standard strains of Klebsiella. Of 296 clinical isolates of Klebsiella, 67% could be typed on the basis of their sensitivity to klebocins. The method proposed in this paper affords a standard basis for the further development of klebocin typing as a suitable procedure for hospital laboratories concerned with epidemiological investigations of hospital-associated infections. Evidence is also provided to show that high-titered klebocin typing can be used in conjunction with biochemical typing to provide a sensitive epidemiological marker for Klebsiella.
D000328:Adult; D001430:Bacteriocins / Q000096:biosynthesis / Q000494:pharmacology*; D004352:Drug Resistance, Microbial; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D007232:Infant, Newborn, Diseases / Q000382:microbiology; D007709:Klebsiella / Q000145:classification* / Q000187:drug effects / Q000378:metabolism; D007710:Klebsiella Infections / Q000382:microbiology; D008937:Mitomycins / Q000494:pharmacology; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000382:microbiology; D014466:Ultraviolet Rays
D001430:Bacteriocins; D008937:Mitomycins