title: Increased phenytoin metabolism in rabbits after phenytoin pretreatment.
abstract: The serum half-life of phenytoin in rabbits after a single intravenous dose was significantly shortened by pretreating the rabbits with daily oral doses of phenytoin. This suggests that in vivo phenytoin induces its own metabolism.
mesh_terms: D000818:Animals; D006207:Half-Life; D010672:Phenytoin / Q000378:metabolism* / Q000494:pharmacology; D011817:Rabbits; D013997:Time Factors
chemical_list: D010672:Phenytoin