The action of cycloheximide on the action potential and protein synthesis in medullated Xenopus axons.
Cycloheximide depresses maximum rate of change in membrane potential observed during the rising phase of the action potential in single medullated axons of Xenopus. To,e course of depression is independent of cycloheximide concentration over a range that almost completely inhibits leucine incorporation into axonal proteins.
D000200:Action Potentials / Q000187:drug effects*; D000818:Animals; D001369:Axons / Q000187:drug effects*; D003513:Cycloheximide / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D004553:Electric Conductivity; D009419:Nerve Tissue Proteins / Q000096:biosynthesis*; D012964:Sodium / Q000378:metabolism; D014981:Xenopus
D009419:Nerve Tissue Proteins; D003513:Cycloheximide; D012964:Sodium