Mouse hydrocephalus and encephalitis following intracerebral infection with Newcastle disease vaccine viruses.
Hydrocephalus and encephalitis in 14-day-old mice was induced by an intracerebral inoculation of a high dose of live Newcastle disease vaccine viruses. The distended lateral ventricles occurred as a result of aqueduct stenosis superimposed on ciliary degeneration and destruction of ependymal cells. The brain virus titres were high on Days 3, 5 and 7 but never exceeded the titre of the original dose given. Positive serum haemagglutination-inhibition titres persisted throughout the experiment.
D000818:Animals; D000956:Antigens, Viral / Q000032:analysis; D001921:Brain / Q000276:immunology / Q000473:pathology; D004660:Encephalitis / Q000276:immunology / Q000473:pathology; D006385:Hemagglutination Inhibition Tests; D006849:Hydrocephalus / Q000209:etiology / Q000473:pathology; D051379:Mice; D009521:Newcastle Disease / Q000276:immunology
D000956:Antigens, Viral