title: 17-Deoxygenation: a new pathway of cortisol metabolism. Isolation of 17-deoxycortolonic acids.
abstract: The existence of a 17-deoxylation pathway in the metabolism of cortisol has been established by isolation of two 17-deoxy metabolites of cortisol. They have been identified as the 20alpha and 20beta-hydroxy isomers of 3alpha,20-dihydroxy, 11-oxo-5beta-pregnan-21-oic acids by comparison of the nuclear magnetic resonance spectra (nmr) and high resolution mass spectra of their methyl esters with authentic samples and confirmed by reverse isotope dilution.
mesh_terms: D006801:Humans; D006854:Hydrocortisone / Q000378:metabolism*; D007536:Isomerism; D009682:Magnetic Resonance Spectroscopy; D008968:Molecular Conformation; D011276:Pregnanediol / Q000031:analogs & derivatives* / Q000096:biosynthesis
chemical_list: C012874:17-deoxycortolonic acid; D011276:Pregnanediol; D006854:Hydrocortisone