title: [Effects of dextran, gelatine and homologous plasma on circulation in shock caused by severe anemia in the dog].
abstract: Irreversible shock is produced in 28 anaesthetized mongrel dogs by withdrawal of erythrocytes and substitution by dextran, gelatine or plasma to an average Hb of 4.5g%. In contrast to other shock models cardiac output and perfusion pressure are not decreased by this preparation. In order to maintain arterial blood pressue above 90 mm Hg significantly more gelatine than dextran or serum has to be infused. There is no difference in hemodynamic responses after treatment with dextran or gelatine respectively. Both groups treated with colloidal solutions have the same survival rate of 38%. In the serum substituted dogs, however,survival rate is significantly greater (83%). Very likely this is due to a greater buffer capacity preventing severe acidosis, which is observed in the animals treated with colloidal solutions.
mesh_terms: D000740:Anemia; D000818:Animals; D001692:Biological Transport; D001794:Blood Pressure; D002302:Cardiac Output; D003911:Dextrans / Q000627:therapeutic use; D004285:Dogs; D005260:Female; D005780:Gelatin / Q000627:therapeutic use; D006339:Heart Rate; D006400:Hematocrit; D006454:Hemoglobins; D008297:Male; D010101:Oxygen Consumption; D010949:Plasma; D010952:Plasma Substitutes / Q000627:therapeutic use*; D012771:Shock, Hemorrhagic / Q000628:therapy*
chemical_list: D003911:Dextrans; D006454:Hemoglobins; D010952:Plasma Substitutes; D005780:Gelatin
vernacular_title: Die Wirkung von Dextran, Gelatine und homologem Blutplasma auf den Kreislauf im Schock durch hochgradige Anämie am Hund