Antiserum to brain gangliosides produces recurrent epileptiform activity.
A single injection of 10 microliters of antiserum to total brain ganglioside onto (and into) the sensorimotor cortex of the rat resulted in recurrent spiking in the cortical electroencephalogram, lasting from 7 to 17 days. Absorption of antibody with pure monosialoganglioside (GM1) completely abosished the effect. Spiking was reactivated after 4 weeks by intramuscular injection of pentylenetetrazole.
D000200:Action Potentials / Q000187:drug effects; D000818:Animals; D000906:Antibodies; D000937:Antigen-Antibody Reactions; D001921:Brain / Q000276:immunology / Q000473:pathology / Q000502:physiology*; D004487:Edema; D005732:Gangliosides / Q000276:immunology / Q000502:physiology*; D007249:Inflammation; D008297:Male; D010433:Pentylenetetrazole / Q000494:pharmacology; D051381:Rats; D012640:Seizures / Q000209:etiology / Q000503:physiopathology*
D000906:Antibodies; D005732:Gangliosides; D010433:Pentylenetetrazole