title: Some effects of phenacetin on the rat.
abstract: Rats aged from 2 to 4 mth were given phenacetin 100 mg/kg/day and 1-14 g/kg/day, orally, for up to 26 1/2 wk and 3 wk, respectively. Signs of premature ageing such as senile plagues, neurofibrillary tangles and lipofucsin pigment were not demonstrated in the brains of these animals.
mesh_terms: D000818:Animals; D001921:Brain / Q000187:drug effects* / Q000378:metabolism; D003490:Cyanosis / Q000139:chemically induced; D005260:Female; D007668:Kidney / Q000187:drug effects*; D008062:Lipofuscin / Q000378:metabolism; D008297:Male; D010615:Phenacetin / Q000633:toxicity*; D051381:Rats
chemical_list: D008062:Lipofuscin; D010615:Phenacetin