High incidence of spontaneous cervical and vaginal tumors in an inbred strain of Brown Norway rats (BN/Bi).
The incidence of spontaneously occurring tumors of the cervix and vagina was unusually high in an inbred strain of Brown Norway rats (BN/Bi). Fifty-four tumors were diagnosed in the cervixes or vaginas of 252 rats. Of the tumors, 7 were squamous cell carcinomas, 4 were leiomyomas, and the rest were sarcomas. These tumors were found in nearly 20% of all female rats that died naturally.
D000818:Animals; D005260:Female; D051381:Rats; D011914:Rats, Inbred BN; D011919:Rats, Inbred Strains; D012376:Rodent Diseases / Q000453:epidemiology* / Q000473:pathology; D002583:Uterine Cervical Neoplasms / Q000453:epidemiology / Q000473:pathology / Q000662:veterinary*; D014625:Vaginal Neoplasms / Q000453:epidemiology / Q000473:pathology / Q000662:veterinary*