title: Rheumatoid arthritis treated with chlorambucil: a five-year follow-up.
abstract: The results of a five-year study of chlorambucil in patients suffering from rheumatoid arthritis are presented. The effect of treatment was to allow a reduction in corticosteroid dosage and a sustained remission of disease activity in patients. Three patients of the series of 22 developed neoplastic disease, and the signficance of this is discussed.
mesh_terms: D000208:Acute Disease; D000368:Aged; D001172:Arthritis, Rheumatoid / Q000188:drug therapy*; D002699:Chlorambucil / Q000009:adverse effects / Q000627:therapeutic use*; D002908:Chronic Disease; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D009369:Neoplasms / Q000139:chemically induced; D011241:Prednisone / Q000627:therapeutic use; D012075:Remission, Spontaneous
chemical_list: D002699:Chlorambucil; D011241:Prednisone