Isolation of a new antibiotic 333-25, related to antibiotic EM 49. (Studies on antibiotics from the genus Bacillus. XI).
A new antibiotic, 333-25, active against Gram-positive and Gram-negative bacteria, was isolated from the culture broth of Bacillus circulans 333-25. The antibiotic is a basic acylpeptide containing 2,4-diaminobutyric acid (5), leucine (2), phenylalanine (1) and a fatty acid. It is closely related to antibiotic EM 49, but can be differentiated by chromatographic behaviour.
D000818:Animals; D000900:Anti-Bacterial Agents / Q000032:analysis / Q000096:biosynthesis / Q000494:pharmacology; D001407:Bacillus / Q000145:classification / Q000166:cytology / Q000378:metabolism; D001419:Bacteria / Q000187:drug effects; D001424:Bacterial Infections / Q000188:drug therapy; D055598:Chemical Phenomena; D002621:Chemistry; D006868:Hydrolysis; D007928:Lethal Dose 50; D051379:Mice; D008813:Mice, Inbred ICR; D010456:Peptides, Cyclic / Q000032:analysis / Q000096:biosynthesis / Q000494:pharmacology
D000900:Anti-Bacterial Agents; D010456:Peptides, Cyclic