title: LDH isoenzyme pattern of uninvolved gastric mucosa of patients with gastric carcinoma and benign gastric disease.
abstract: The LDH isoenzyme pattern of the uninvolved mucosa of gastric cancer patients differs as regards the LDH isoenzyme pattern from that of similar tissue of patients with benign gastric disease; the former tissue is characterised by a high M/H ratio of the LDH isoenzymes (M and H sub-units). A high M/H ratio characterises antral mucosa when the latter is compared with fundic mucosa. Mucosa showing superficial and atrophic gastritis also has a higher M/H ratio, whereas the presence of intestinal metaplasia does not appear to influence the M/H ratio. These observations are consistent with the concept that the tissue from which the cancer arose may possess a pre-malignant biochemical lesion.
mesh_terms: D004381:Duodenal Ulcer / Q000201:enzymology; D005753:Gastric Mucosa / Q000201:enzymology*; D005756:Gastritis / Q000201:enzymology; D006801:Humans; D007410:Intestinal Diseases / Q000201:enzymology; D007527:Isoenzymes; D007770:L-Lactate Dehydrogenase / Q000032:analysis; D008679:Metaplasia; D013272:Stomach Diseases / Q000201:enzymology*; D013274:Stomach Neoplasms / Q000201:enzymology*; D013276:Stomach Ulcer / Q000201:enzymology
chemical_list: D007527:Isoenzymes; D007770:L-Lactate Dehydrogenase