Profiles of ultraviolet-absorbing components of urine from autistic children, as obtained by high-resolution ion-exchange chromatography.
Urines from 19 autistic children (3 female, 16 male) were analyzed by high-resolution, high-pressure anion-exchange chromatography. The results showed abnormalities in the excretion of hippuric acid, 4-hydroxyhippuric acid, and N1-methyl-2-pyridone-5-carboxamide, the end product of the nicotinic acid pathway. Considerations as the metabolic origin on the 4-hydroxyhippuric acid are discussed and related to the possibility of bacterial action and malabsorption.
D001321:Autistic Disorder / Q000188:drug therapy / Q000652:urine*; D001419:Bacteria / Q000378:metabolism; D002648:Child; D002851:Chromatography, High Pressure Liquid; D002852:Chromatography, Ion Exchange; D004064:Digestive System / Q000382:microbiology; D005260:Female; D006626:Hippurates / Q000652:urine*; D006801:Humans; D008286:Malabsorption Syndromes / Q000652:urine; D008297:Male; D009539:Nicotinic Acids / Q000378:metabolism; D013056:Spectrophotometry, Ultraviolet; D014118:Toxins, Biological / Q000096:biosynthesis; D014815:Vitamins / Q000627:therapeutic use
D006626:Hippurates; D009539:Nicotinic Acids; D014118:Toxins, Biological; D014815:Vitamins