Regulation of progesterone biosynthesis in human placental mitochondria by Krebs cycle metabolites.
1. 2-Oxoglutarate, succinate, fumarate, malate and citrate, cis-aconitate and isocitrate stimulate conversion of cholesterol to progesterone in human placental mitochondria. 2. The stimulatory effect of dicarboxylic and tricarboxylic acids depends on the activity of malate dehydrogenase (decarboxylating) (NADP+) (EC 1.1.1.40) and isocitrate dehydrogenase (NADP+) (EC 1.1.1.42), respectively.
D000156:Aconitic Acid / Q000494:pharmacology; D002951:Citrates / Q000494:pharmacology; D002952:Citric Acid Cycle; D004357:Drug Synergism; D005260:Female; D005650:Fumarates / Q000494:pharmacology; D006801:Humans; D007521:Isocitrate Dehydrogenase / Q000378:metabolism; D007523:Isocitrates / Q000494:pharmacology; D007656:Ketoglutaric Acids / Q000494:pharmacology; D008291:Malate Dehydrogenase / Q000378:metabolism; D008293:Malates / Q000494:pharmacology; D008314:Malonates / Q000494:pharmacology; D008345:Manganese / Q000494:pharmacology; D008928:Mitochondria / Q000187:drug effects / Q000378:metabolism*; D010920:Placenta / Q000378:metabolism*; D011247:Pregnancy; D011374:Progesterone / Q000096:biosynthesis*; D013386:Succinates / Q000494:pharmacology
D002951:Citrates; D005650:Fumarates; D007523:Isocitrates; D007656:Ketoglutaric Acids; D008293:Malates; D008314:Malonates; D013386:Succinates; D008345:Manganese; D011374:Progesterone; D000156:Aconitic Acid; D008291:Malate Dehydrogenase; D007521:Isocitrate Dehydrogenase