Effect of prostaglandins on vascular resistance and adrenergic vasoconstrictor responses in the canine uterus.
Prostaglandins appear to play an important role in a number of reproductive processes. The effect of prostaglandins on numerous vascular beds has been extensively studied, but the effects on uterine hemodynamics have not. The present study was designed to determine the effects of prostaglandins of the A and E series on uterine vascular resistance and responses to adrenergic nerve stimulation in the canine uterus. PGE1, PGE2 and PGA1 were found to be potent uterine vasodilators. In addition, these agents were able to modify adrenergic vasoconstrictor responses. These effects on uterine vascular resistance and adrenergic vasoconstrictor responses were separable. The results of these studies suggest that prostaglandins of the A and E series may play an important role in regulating uterine blood flow in the nonpregnant animal.
D000818:Animals; D004285:Dogs; D005260:Female; D009638:Norepinephrine / Q000494:pharmacology; D011453:Prostaglandins / Q000494:pharmacology*; D011454:Prostaglandins A / Q000494:pharmacology; D011458:Prostaglandins E / Q000494:pharmacology; D013564:Sympathetic Nervous System / Q000187:drug effects; D014590:Uterine Contraction / Q000187:drug effects; D014599:Uterus / Q000098:blood supply / Q000187:drug effects*; D014655:Vascular Resistance / Q000187:drug effects*
D011453:Prostaglandins; D011454:Prostaglandins A; D011458:Prostaglandins E; D009638:Norepinephrine