A sensitive method for the determination of amitriptyline and nortriptyline in human plasma.
A highly sensitive and reproducible GLC technique for the quantitation of amitriptyline and nortriptyline is described. The lower limit of detection is less than 1 ng/ml. 5 ng/ml samples (3 ml aliquots) can be accurately quantified (C of V less than 5%). Steady state data are reported together with data on amitriptyline and nortriptyline levels obtained in a volunteer who ingested a single oral dose (25 mg) of amitriptyline (Elavil).
D000328:Adult; D000639:Amitriptyline / Q000097:blood*; D002849:Chromatography, Gas; D006801:Humans; D008297:Male; D008722:Methods; D009661:Nortriptyline / Q000097:blood*; D013997:Time Factors
D000639:Amitriptyline; D009661:Nortriptyline