The effects of 3-hydrazine-6[N,N-bis(2-hydroxyethyl)-amino]-pyridazine dihydrochloride (L6150) on the general and cardiac haemodynamics of the intact dog.
1. The effects of 3-hydrazine-6[N,N-bis(2-hydroxyethyl)amino]-pyridazine dihydrochloride (L6150) were studied in intact anaesthetized dogs. 2. In a dose of 1 mg/kg/(i.v.) the drug increased respiration rate, cardiac output, and left and right ventricular work. 3. It decreased femoral pressure and systemic and total pulmonary resistance. 4. It increased coronary flow and coronary sinus O2 content. 5 The drug also increased whole body glucose, lactate, pyruvate and NEFA values.
D000818:Animals; D000959:Antihypertensive Agents; D003326:Coronary Circulation / Q000187:drug effects*; D004285:Dogs; D004983:Ethanolamines / Q000494:pharmacology*; D006439:Hemodynamics / Q000187:drug effects*; D009206:Myocardium / Q000378:metabolism; D010101:Oxygen Consumption / Q000187:drug effects; D011724:Pyridazines / Q000494:pharmacology*; D012119:Respiration / Q000187:drug effects; D013997:Time Factors
D000959:Antihypertensive Agents; D004983:Ethanolamines; D011724:Pyridazines