Development of the aging cell surface: a freeze-fracture analysis of gap junctions between human embryo fibroblasts aging in culture. A brief note.
Gap junctions have been identified between cells in late passage cultures of human embryo fibroblasts using techniques of freeze-fracture and electron microscopy. The junctions are sparsely distributed, which may suggest a decrease in electrotonic and metabolic coupling with increased age in culture.
D002462:Cell Membrane / Q000378:metabolism / Q000648:ultrastructure*; D002478:Cells, Cultured; D004622:Embryo, Mammalian; D005347:Fibroblasts / Q000378:metabolism / Q000648:ultrastructure; D005614:Freeze Fracturing; D006801:Humans