Effect of charcoal-broiled beef on phenacetin metabolism in man.
When charcoal-broiled beef was fed to human volunteers, who were then given phenacetin orally, the concentration of phenacetin in the plasma was lowered, but its half-life in the plasma was not changed. The data suggest that feeding charcoal-broiled beef enhances the metabolism of orally administered phenacetin in the intestine or during its first pass through the liver, or both.
D000328:Adult; D002606:Charcoal; D004032:Diet; D004064:Digestive System / Q000378:metabolism; D005260:Female; D006801:Humans; D008099:Liver / Q000378:metabolism; D008297:Male; D008460:Meat; D008657:Metabolic Clearance Rate; D010615:Phenacetin / Q000378:metabolism*
D002606:Charcoal; D010615:Phenacetin