Bone-resorbing activity in the sera of patients with rheumatoid arthritis.
1. Foetal rat hemi-calvaria were incubated in organ culture with sera from patients with active rheumatoid arthritis. 2. Increased 45Ca resorption was produced by sera from patients who were hypercalcaemic. 3. This bone-resorbing effect could be inhibited by calcitonin.
D000818:Animals; D001172:Arthritis, Rheumatoid / Q000097:blood / Q000503:physiopathology*; D001862:Bone Resorption; D001842:Bone and Bones / Q000187:drug effects / Q000502:physiology / Q000503:physiopathology; D002116:Calcitonin / Q000494:pharmacology; D002118:Calcium / Q000378:metabolism / Q000494:pharmacology; D005260:Female; D005333:Fetus; D010281:Parathyroid Hormone / Q000494:pharmacology; D011247:Pregnancy; D051381:Rats
D010281:Parathyroid Hormone; D002116:Calcitonin; D002118:Calcium