Synapse formation in retinoblastoma tumours.
Developing photoreceptor-like cells in retinoblastoma tumour fleurettes were found to contain apical tight junctions, mitochondrial-filled inner segment regions with cilia, and basally located synaptic ribbons and vesicles. Synaptic contract appeared to be established with adjacent neuronal-like elements. We suggest that photoreceptor differentiation in retinoblastoma tumours follows a sequence similar to normal human photoreceptor embryogenesis.
D006801:Humans; D008854:Microscopy, Electron; D010786:Photoreceptor Cells / Q000473:pathology / Q000648:ultrastructure; D012160:Retina / Q000473:pathology / Q000648:ultrastructure; D012175:Retinoblastoma / Q000473:pathology*; D013569:Synapses / Q000473:pathology*