The effect of antisynaptosomal plasma membrane antibodies on memory.
Antisynaptosomal plasma membrane antibodies were introduced through an infusion cannula into rat brain and their effects on behaviour were tested. Four different learning paradigms were used, two appetitively and two aversively motivated, to show impairment in memory retrieval. No effects were found on aquisition, motor activity, or motivation.
D000818:Animals; D001323:Autoantibodies; D001362:Avoidance Learning / Q000502:physiology; D003214:Conditioning, Classical / Q000502:physiology; D004193:Discrimination Learning / Q000502:physiology; D008297:Male; D008568:Memory / Q000502:physiology*; D051381:Rats; D013570:Synaptic Membranes / Q000276:immunology*
D001323:Autoantibodies