[Transformation of monocytes into fibroblasts in wound healing (author's transl)].
Recent investigations of HELPAP and CREMER 1972 seem to confirm the supposition of COHNHEIM 1867 that monocytes of the peripheral blood are transformed into firbroblasts in healing wounds. The view of VIRCHOW 1871, MARCHAND 1901 and ASCHOFF 1924 that the fibroblasts in healing wounds are of local origin seems to be supported by the invesigation on parabiotic inbred rats of ROSS et al. 1970. We thought that irradiating the whole body of rabbits could be of value in resolving these apparent contradictions about the origin of fibroblasts in healing wounds.
D000818:Animals; D002454:Cell Differentiation; D005347:Fibroblasts / Q000502:physiology*; D005720:Gamma Rays; D008297:Male; D009000:Monocytes / Q000502:physiology*; D011817:Rabbits; D014945:Wound Healing / Q000528:radiation effects
Zur Frage der Umwandlung haematogener Monozyten zu Fibroblasten in heilenden Wunden