Antiradiation compounds XVI: N-heterocyclic aminoethyl disulfides and aminoethanethiosulfuric acids.
A series of N-heterocyclic and N-heterocyclic alkyl derivatives of bis(2-aminoethyl) disulfide and aminoethanethiosulfuric acid was synthesized as potential antiradiation and anticancer agents. The compounds were prepared by the reactions of the heterocyclic halides with bis(2-aminoethyl) disulfide and aminoethanethiosulfuric acid. A dithio acid derivative, 3,3-dimercapto-2-cyanoacryloylpyrrolidide, was also prepared. Several compounds, including the dithio acid derivative, provided good radiation protection to mice. None of the compounds screened showed appreciable anticancer activities in two leukemia systems.
D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology; D055598:Chemical Phenomena; D002621:Chemistry; D006571:Heterocyclic Compounds / Q000138:chemical synthesis / Q000494:pharmacology*; D051379:Mice; D011830:Radiation Effects; D011837:Radiation-Protective Agents / Q000138:chemical synthesis / Q000494:pharmacology*; D013885:Thiosulfates / Q000138:chemical synthesis / Q000494:pharmacology*
D000970:Antineoplastic Agents; D006571:Heterocyclic Compounds; D011837:Radiation-Protective Agents; D013885:Thiosulfates