A diminution of enzyme release in the anoxic guinea-pig heart observed after cardoiplegic treatment.
1. Under anaerobic conditions there was an increase in the release of malate dehydrogenase, lactate dehydrogenase and creatine phosphokinase from isolated perfused guinea-pig hearts. 2. The increased enzyme releases were significantly reduced by pretreatment with cardioplegic solution. 3. This finding suggests a relationship between myocardial energy metabolism and enzyme release or retention.
D000818:Animals; D003402:Creatine Kinase / Q000378:metabolism; D006168:Guinea Pigs; D000860:Hypoxia / Q000201:enzymology*; D066298:In Vitro Techniques; D007770:L-Lactate Dehydrogenase / Q000378:metabolism; D008291:Malate Dehydrogenase / Q000378:metabolism; D009206:Myocardium / Q000201:enzymology*; D010101:Oxygen Consumption; D010477:Perfusion; D013997:Time Factors
D007770:L-Lactate Dehydrogenase; D008291:Malate Dehydrogenase; D003402:Creatine Kinase