Excision of ultraviolet and gamma ray products of the 5,6-dihydroxy-dihydrothymine type by nuclear preperations of xeroderma pigmentosum cells.
Monomeric products of the 5,6-dihydroxy-dihydrothymine type are produced in the DNA by both ultraviolet and ionizing radiations. The capacity of nuclear preparations from normal and Xeroderma pigmentosum (XP) cells (Complementation groups A, B, C and D) to excise such products from ultraviolet or gamma-irradiated T7DNA was comparable and was independent of radiation induced strand breaks.
D002467:Cell Nucleus / Q000528:radiation effects*; D003090:Coliphages; D004247:DNA / Q000528:radiation effects*; D004260:DNA Repair; D004279:DNA, Viral / Q000528:radiation effects; D005347:Fibroblasts / Q000528:radiation effects; D005720:Gamma Rays; D013941:Thymine / Q000031:analogs & derivatives* / Q000378:metabolism; D014466:Ultraviolet Rays; D014983:Xeroderma Pigmentosum / Q000378:metabolism*
D004279:DNA, Viral; D004247:DNA; D013941:Thymine