[Mechanism of action of benzene on hematopoiesis (a study of hematopoietic stem cells)].
A study was made of the effect of benzol on the colony-forming activity in the spleen and the bone marrow of mice in 4 different experimental variants. In benzol hypoplasia of hemopoiesis there was a decrease in the number of the CFU in the hemopoietic organs without any changes in the distribution of their cell types. Incubation of the cells of normal mouse bone marrow with benzol did not induce any decrease of the colony-forming efficiency. Administration of benzol to the lethally irradiated mice after the transplantation of normal bone marrow suspension led to a sharp decrease in the number of CFU with a preponderant depression of the granulocytic colony formation. These data afford to suppose the change in the properties of microenvironment of the hemopoietic stem cells in experimental benzol poisoning.
D000367:Age Factors; D000818:Animals; D001554:Benzene / Q000494:pharmacology*; D001853:Bone Marrow / Q000187:drug effects*; D001854:Bone Marrow Cells; D002999:Clone Cells; D005260:Female; D006410:Hematopoiesis / Q000187:drug effects*; D006412:Hematopoietic Stem Cells / Q000187:drug effects; D008297:Male; D051379:Mice; D008808:Mice, Inbred CBA; D013154:Spleen / Q000187:drug effects*
D001554:Benzene
K mekhanizmu deĭstviia benzola na krovetvorenie (issledovanie gemopoéticheskikh stvolovykh kletok)