Characterization of Orungo virus, an orbivirus from Uganda and Nigeria.
Orungo virus was studied in cell culture and mice by light and electron microscopy. The virus developed in the cytoplasm of infected cells in mouse brain and cell culture in association with a specific viral granular matrix and accompanying filaments. Virus particle size was 63 nm with a core diameter of 34 nm. Most particles were released from infected cells by lysis, but some budded through membranes and assumed a "pseudoenvelope". In its morphology and mode of morphogenesis, Orungo virus was indistinguishable from other described orbiviruses.
D000818:Animals; D001921:Brain / Q000382:microbiology / Q000473:pathology; D002460:Cell Line; D002462:Cell Membrane / Q000382:microbiology; D006224:Cricetinae; D003588:Cytopathogenic Effect, Viral; D003593:Cytoplasm / Q000382:microbiology; D051379:Mice; D008928:Mitochondria / Q000382:microbiology; D009024:Morphogenesis; D009549:Nigeria; D012328:RNA Viruses / Q000254:growth & development / Q000648:ultrastructure; D014454:Uganda; D014779:Virus Replication