The pharmacokinetics of ephedrine after oral dosage in asthmatics receiving acute and chronic treatment.
1 Ephedrine plasma levels have been measured in ten asthmatic patients given a singel dose of ephedrine hydrochloride (22 mg) along and in combination with theophylline and a barbiturate. 2 Pharmacokinetic assessment of the data indicated no significant intra-subject changes in kinetic parameters before or after chronic treatment with ephedrine HCl (11 mg three times a day) alone or in combination. 3 Tolerance to these therapeutic doses, if it occurs, is therefore not disposition-related but rather to pharmacodynamic changes.
D000284:Administration, Oral; D000328:Adult; D001249:Asthma / Q000188:drug therapy*; D001682:Biological Availability; D004359:Drug Therapy, Combination; D004361:Drug Tolerance; D004809:Ephedrine / Q000097:blood / Q000494:pharmacology / Q000627:therapeutic use*; D005260:Female; D006207:Half-Life; D006801:Humans; D008297:Male; D008875:Middle Aged; D010634:Phenobarbital / Q000627:therapeutic use; D013806:Theophylline / Q000627:therapeutic use
D013806:Theophylline; D004809:Ephedrine; D010634:Phenobarbital