Treatment of extrahepatic occlusive jaundice with activated charcoal hemoperfusion in dogs.
To find the feasibility of treatment for congenital bile duct atresia, we studied the usefullness of extracorporeal hemoperfusion over activated charcoal in canine obstructive jaundice. One, three and five weeks after ligation and disection of common bile duct in 5 dogs we performed the hemoperfusion over activated charcoal extracorporeally (group 3). In this animals we examined hematological and blood coagulation studies, serum electrolyte levels, kidney function tests and liver chemistries. As control in 5 animals we carried out after sham operation the perfusion without common bile duct ligation (group 2) and in 5 animals only common bile duct ligation without perfusion (group 1). In the liver chemistries we found 2 weeks after 2nd and 3rd perfusion (5 and 7 weeks after bile duct ligation) lower levels of serum bilirubin, GOT, GPT and SDH in treated group than in non-treated jaundiced animals. It suggest the effectiveness of hemoperfusion with activated charcoal in the treatment of occlusive jaundice. There were no alteration in the hematological studies, serum electrolyte levels and kidney function tests. PT and PTT was prolonged in the jaundiced animals there were no significant differences with and without hemoperfusion.
D000818:Animals; D001663:Bilirubin / Q000032:analysis; D001779:Blood Coagulation Factors / Q000032:analysis; D002606:Charcoal / Q000627:therapeutic use*; D002779:Cholestasis / Q000097:blood / Q000201:enzymology / Q000628:therapy*; D003135:Common Bile Duct / Q000002:abnormalities / Q000601:surgery; D000013:Congenital Abnormalities / Q000628:therapy; D004195:Disease Models, Animal; D004285:Dogs; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D011516:Prothrombin / Q000032:analysis; D006435:Renal Dialysis / Q000379:methods*
D001779:Blood Coagulation Factors; D002606:Charcoal; D011516:Prothrombin; D001663:Bilirubin