[Behavior of some parameters of lipid and energy metabolism. 2. Activity of citrate synthase, ATP citrate lyase, fatty acid synthase, and glucose-6-phosphate dehydrogenase in liver of growing rats on diets differing in fat content].
In continuation of previous investigations, the authors studied the behaviour of the activities of certain enzymes (citrate synthase, adenosine triphosphate citrate lyase, fatty acid synthase and glucose-6-phosphate dehydrogenase) in the livers of growing rats on diets differing in fat content. A high-fat diet resulted in a reduction of the activities of fatty acid synthase, glucose-6-phosphate dehydrogenase and adenosine triphosphate citrate lyase, whereas the activity of citrate synthase increased, which is interpreted in the sense of an acceleration of the introduction of acetyl residues into the citrate cycle for the purpose of oxidative final degradation, and as a removal of acetyl CoA for the purpose of fatty acid synthesis.
D001275:ATP Citrate (pro-S)-Lyase / Q000378:metabolism*; D000105:Acetyl Coenzyme A / Q000378:metabolism; D000818:Animals; D002950:Citrate (si)-Synthase / Q000378:metabolism*; D002952:Citric Acid Cycle; D004041:Dietary Fats; D064429:Fatty Acid Synthases / Q000378:metabolism*; D005227:Fatty Acids / Q000096:biosynthesis; D005954:Glucosephosphate Dehydrogenase / Q000378:metabolism*; D006128:Growth; D008099:Liver / Q000201:enzymology*; D008297:Male; D010084:Oxidation-Reduction; D007652:Oxo-Acid-Lyases / Q000378:metabolism*; D051381:Rats
D004041:Dietary Fats; D005227:Fatty Acids; D000105:Acetyl Coenzyme A; D005954:Glucosephosphate Dehydrogenase; D064429:Fatty Acid Synthases; D002950:Citrate (si)-Synthase; D001275:ATP Citrate (pro-S)-Lyase; D007652:Oxo-Acid-Lyases
Untersuchungen zum Verhalten einiger Kenngrössen des Lipid- und Energiestoffwechsels. 2. Mitt. Das Aktivitätsverhalten von Citratsynthase, ATP-Citratlyase, Fettsäuresynthase und Glucose-6-Phosphat-Dehydrogenase im Lebergewebe wachsender Ratten nach Fütterung unterschiedlicher Fettdiäten