Effect of propranolol on the release of choline from guinea-pig small intestine in vitro.
1. Choline was released into the fluid bathing the serosal surface of segments of guinea-pig small intestine. The mean rate of release (nmol choline per cm of intestine per h) in the first hour was 10-2 and in the second hour 8-0. 2. Propranolol 1 mM in the mucosal fluid caused a significant (P less than 0-01) increase in the rate at which choline was released into the serosal fluid. The mean rates were 15-4 and 19-2 for the first and second hour, respectively. 3. It is suggested that the effect of propranolol observed in the present study is likely to be due to a non-specific direct action on biological membranes.
D000818:Animals; D001826:Body Fluids / Q000378:metabolism; D002794:Choline / Q000378:metabolism*; D005260:Female; D006168:Guinea Pigs; D066298:In Vitro Techniques; D007413:Intestinal Mucosa / Q000187:drug effects; D007421:Intestine, Small / Q000187:drug effects / Q000378:metabolism*; D008297:Male; D011433:Propranolol / Q000494:pharmacology*; D013997:Time Factors
D011433:Propranolol; D002794:Choline