Intracerebral implantation of the anti-estrogen CN-69, 725-27: Effects on female sexual behavior in rats.
Ovariectomized adult female rats were stereotaxically implanted with double walled cannulas (22 ga outer and 27 ga inner) and tested for sexual receptivity (lordosis behavior) following SC estradiol benzoate and progesterone priming. Implantation of the anti-estrogen CN-69,725-27 (c. 65 mug) immediately after the first of 3 daily estrogen injections produced a dramatic inhibition of sexual receptivity when these implants were placed in the preoptic and anterior hypothalamic areas. CN-69,725-27 implants had no effect on receptivity when implanted in the middle hypothalamus, mesencephalon or frontal cortex. All inhibitory effects of the anti-estrogen were reversible within one day after removal of the CN-69,725-27 cannula from the brain.
D000818:Animals; D001921:Brain / Q000033:anatomy & histology; D004343:Drug Implants; D004965:Estrogen Antagonists; D005260:Female; D010053:Ovary / Q000502:physiology; D011187:Posture / Q000187:drug effects; D051381:Rats; D012726:Sexual Behavior, Animal / Q000187:drug effects*
D004343:Drug Implants; D004965:Estrogen Antagonists