title: Rectification in the smooth muscle cell membrane of rabbit aorta.
abstract: 1. The current-voltage relation of the smooth muscle cell membrane of rabbit aorta was determined by the partition method. 2. No anomalous rectification was observed in any of the following solutions: normal Krebs, Na free choline, Na sulphate, and high K-Na free sulphate. 3. Delayed rectification was seen on application of depolarizing current in both normal Krebs solution and Na free choline solution. 4. High concentration of K made the steady-state current-voltage relation almost linear in a voltage range of about 0 to -20mV. This effect, and steady-state cathodal rectification which was seen in physiological solution, could be explained qualitatively by constant field theory without involving channels capable of anomalous rectification. 5. A slow decrease in K conductance, during application of large and long-lasting hyperpolarizing currents, which occurs in skeletal muscle and is attributed to the tubule system, was never observed in the arteries either in Krebs, Na-free choline, or Na sulphate solution.
mesh_terms: D000818:Animals; D001011:Aorta / Q000502:physiology*; D002462:Cell Membrane / Q000502:physiology; D002794:Choline / Q000494:pharmacology; D004553:Electric Conductivity; D008564:Membrane Potentials / Q000187:drug effects; D008954:Models, Biological; D009130:Muscle, Smooth / Q000502:physiology; D011188:Potassium / Q000494:pharmacology; D011817:Rabbits; D012964:Sodium / Q000494:pharmacology; D012965:Sodium Chloride / Q000494:pharmacology
chemical_list: D012965:Sodium Chloride; D012964:Sodium; D002794:Choline; D011188:Potassium