Inhibition of viral multiplication by homologous methylated ribonucleic acids. V. Inhibition of myxoviruses in mouse.
Mice respond to intravenous injection of homologous methylated RNA by the production of a circulating interferon-like substance. The treatment with modified RNA induces a significant protection against viral infection. This effect is optimum when the treatment occurs a few hours before viral infection. The protective effect is a peculiar property of homologous methylated RNA as heterologous RNAs do not induce any resistance to the infection with influenza virus.
D000818:Animals; D004305:Dose-Response Relationship, Drug; D007372:Interferons / Q000494:pharmacology; D051379:Mice; D008970:Molecular Weight; D009975:Orthomyxoviridae / Q000187:drug effects / Q000378:metabolism*; D011070:Poly I-C / Q000494:pharmacology; D012313:RNA / Q000494:pharmacology*; D014779:Virus Replication / Q000187:drug effects*
D012313:RNA; D007372:Interferons; D011070:Poly I-C