A search for new anticonvulsant compounds among 3-aryl-5-benzylidene derivatives of 2-thiohydantoin.
13 New 3-aryl-5-benzylidene-2-thiohydantoins were obtained by condensation of 3-o-tolyl- and 3-m-tołyl-2--thiohydantoin with aromatic aldehydes. The structure of the obtained compounds was confirmed by IR spectra. Derivatives of 2-thiohydantoin 1-13 show weak anticonvulsant activity in pentetrazole test and show no protecting activity against the maximal electric shock.
D000818:Animals; D000927:Anticonvulsants; D055598:Chemical Phenomena; D002621:Chemistry; D004597:Electroshock; D005260:Female; D006827:Hydantoins / Q000494:pharmacology*; D007928:Lethal Dose 50; D008297:Male; D051379:Mice; D010433:Pentylenetetrazole / Q000037:antagonists & inhibitors; D010672:Phenytoin / Q000494:pharmacology; D013867:Thiohydantoins / Q000138:chemical synthesis / Q000494:pharmacology* / Q000633:toxicity
D000927:Anticonvulsants; D006827:Hydantoins; D013867:Thiohydantoins; D010672:Phenytoin; D010433:Pentylenetetrazole