Genetic control of the immune response to ferritin in mice.
The immune response to the antigen horse spleen ferritin was tested in sixteen inbred strains of mice. Using a fixed antigen percentage  bound isotope technique, it was found that the quantity of antibody produced was related to the genetic status of the responding animal. A continuous distribution of responses was obtained, which were found to be linked to H-2 loci and the 2 non-H-2 loci 'Tla' and 'Theta' and these responses are detectable following primary immunization. It is suggested that the continuous distribution of quantitative antibody responses to ferritin, is compatible either with a large number of IR-genes or with a cross tolerance hypothesis requiring no IR-genes at all.
D000704:Analysis of Variance; D000818:Animals; D000917:Antibody Formation; D005260:Female; D005293:Ferritins / Q000276:immunology*; D005796:Genes; D051379:Mice; D008815:Mice, Inbred Strains; D013045:Species Specificity
D005293:Ferritins