Fibrin thrombi, a cause of clindamycin-associated colitis?
Rectal biopsies from five patients with clindamycin-associated colitis were studied with the intention of identifying fibrin thrombi in capillaries. Capillary thrombosis was present in all five cases, three with pseudomembranous colitis and two with non-specific colitis. The significance of capillary thrombosis and its relationship to other ischaemic lesions of the gut are discussed.
D000368:Aged; D001706:Biopsy; D002981:Clindamycin / Q000009:adverse effects*; D003092:Colitis / Q000139:chemically induced* / Q000473:pathology; D003967:Diarrhea / Q000139:chemically induced; D005260:Female; D005337:Fibrin; D006801:Humans; D007413:Intestinal Mucosa / Q000473:pathology; D008297:Male; D008875:Middle Aged; D012007:Rectum / Q000473:pathology; D013927:Thrombosis / Q000139:chemically induced*
D002981:Clindamycin; D005337:Fibrin