title: In vivo incorporation of glucose carbon into brain and liver proteins in biotin-deficient rats.
abstract: The in vivo utilization of D[U-14C]glucose with particular reference to its incorporation into brain and liver proteins was studied in biotin-deficient rats. The data show a significant reduction in the incorporation of glucose carbon into brain and liver proteins. A disturbance in the intermediary metabolism of glucose to be one of the factors responsible for the decreased incorporation of the label into proteins in biotin deficiency.
mesh_terms: D000818:Animals; D001710:Biotin / Q000172:deficiency*; D001835:Body Weight; D001921:Brain / Q000378:metabolism*; D005947:Glucose / Q000378:metabolism*; D008099:Liver / Q000378:metabolism*; D008297:Male; D009419:Nerve Tissue Proteins / Q000096:biosynthesis; D014176:Protein Biosynthesis; D051381:Rats; D013997:Time Factors; D014804:Vitamin B Deficiency / Q000378:metabolism
chemical_list: D009419:Nerve Tissue Proteins; D001710:Biotin; D005947:Glucose