title: [Regulation of respiration under conditions of inhibition of carbonic anhydrase activity by diamox].
abstract: The functional state of the respiratory center and the mechanism of increase in pulmonary ventilation before and after inhibition of activity of carbonic anhydrase by diamox were studied in anesthetized cats. During the inhibition, activity of bulbar inspiratory neurons functionally connected with motoneurons of the diaphragm was markedly reduced and that of the neurons connected with motoneurons of intercostal muscles was sharply increased. A steady thoracic respiration occurred. The aferents from the carotid sinus nerve and vagus nerve did not affect the steady thoracic respiration. Increased efferent influence upon the intercostal muscles led to forced thoracic respiration which ensured a high pulmonary ventilation during the whole period of action of the diamox.
mesh_terms: D000086:Acetazolamide / Q000494:pharmacology*; D000136:Acid-Base Equilibrium / Q000187:drug effects; D000818:Animals; D002245:Carbon Dioxide / Q000097:blood; D002346:Carotid Sinus / Q000502:physiology; D002415:Cats; D004594:Electrophysiology; D010100:Oxygen / Q000097:blood; D012119:Respiration / Q000187:drug effects*; D012125:Respiratory Center / Q000187:drug effects*; D014628:Vagotomy
chemical_list: D002245:Carbon Dioxide; D000086:Acetazolamide; D010100:Oxygen
vernacular_title: Reguliatsiia dykhaniia v usloviiakh tormozheniia aktivnosti fermenta karboangidrazy diamoksom