title: Differences in cell surface proteins of drug resistant and sensitive cell lines.
abstract: Lactoperoxidase catalyzed iodination of cell surface proteins has been used to compare theophylline and ouabain resistant variants with the drug sensitive parental cell lines. In cells showing contact inhibition a high molecular weight protein was observed to be preferentially labelled. In contrast this was not observed for non contact inhibited cells. These results support a previously suggested correlation between growth regulation and the exposure of this cell surface protein.
mesh_terms: D000818:Animals; D002455:Cell Division; D002460:Cell Line; D002462:Cell Membrane / Q000032:analysis / Q000502:physiology*; D003260:Contact Inhibition; D004351:Drug Resistance; D007784:Lactoperoxidase; D051379:Mice; D008968:Molecular Conformation; D008970:Molecular Weight; D009374:Neoplasms, Experimental; D010042:Ouabain / Q000494:pharmacology; D010954:Plasmacytoma; D011506:Proteins / Q000032:analysis / Q000502:physiology*; D013806:Theophylline / Q000494:pharmacology
chemical_list: D011506:Proteins; D010042:Ouabain; D013806:Theophylline; D007784:Lactoperoxidase