Viability of extracorporeally perfused dog livers.
The possibility of structural and functional preservation of the isolated liver has been studied in dog experiments. A sterile liver preparation left in situ was worked out, having practically no ischaemic period, except during perfusion. Nevertheless, well-defined lesions (perivascular and interstitial oedema, dissociated contraction of the smooth muscle elements of the veins, cellula accumulation in the sinusoids) appeared, accompanied by a gradual reduction (microcirculatory disorders, enzyme derailment) of the function of hepatocytes.
D000818:Animals; D004285:Dogs; D008099:Liver / Q000033:anatomy & histology / Q000378:metabolism / Q000502:physiology; D010101:Oxygen Consumption; D010477:Perfusion; D014022:Tissue Survival