title: Renal sugar transport in the winter flounder. I. Renal clearance studies.
abstract: The renal handling of several sugars was examined using clearance techniques in the winter flounder Pseudopleuronectes americanus. The nonmetabolizable sugar alpha-methyl-D-glucoside was extensively reabsorbed, with consequent accumulation in renal tissue to nearly twice plasma concentration. Both glucose and phlorizin abolished reabsorption and reduced tissue-to-plasma ratios (T/P). D-Galactose was reabsorbed. However, the T/P for free galactose was only 0.6 (total sugar was 1.7). Glucose and phlorizin produced only a transient decrease in reabsorption and no change in T/P. 2-Deoxy-D-glucose showed neither net reabsorption nore secretion. Nevertheless, kidney T/P were inexcess of 6 for total sugar and 1.2 for free sugar, indicating entry through the peritubular face of the tubule. Neither glucose nor phlorizin altered 2-deoxy-D-glucose clearance, but both reduced T/P for total sugar (2.4) and free sugar (0.7). Thus, several systems govern the handling of these sugars at the luminal membrane of the renal tubule, just as has been previously demonstrated at the peritubular membrane in this species.
mesh_terms: D000818:Animals; D003837:Deoxy Sugars / Q000378:metabolism*; D003847:Deoxyglucose / Q000097:blood / Q000378:metabolism*; D005399:Fishes / Q000378:metabolism*; D005690:Galactose / Q000378:metabolism*; D005693:Galactosemias; D005919:Glomerular Filtration Rate; D005947:Glucose / Q000494:pharmacology; D007684:Kidney Tubules / Q000378:metabolism*; D008757:Methylglucosides / Q000097:blood / Q000378:metabolism*; D008759:Methylglycosides / Q000378:metabolism*; D010695:Phlorhizin / Q000494:pharmacology
chemical_list: D003837:Deoxy Sugars; D008757:Methylglucosides; D008759:Methylglycosides; D003847:Deoxyglucose; D010695:Phlorhizin; D005947:Glucose; D005690:Galactose