Clinical use of tobramycin in patients with surgical infections due to gram-negative bacilli.
Twenty-three patients with acute peritonitis, intraabdominal abscess, wound infections (including infection of serious burns), sepsis accompanying renal transplantation, or urinary tract infection associated with cancer were treated with various dosage regimens of tobramycin, and their clinical responses were analysed. For the conditions studied, the optimal regimen was 3 mg/kg per day in three divided doses. No clinical effectiveness was noted in this study for doses of greater than or equal to 4 mg/kg per day.
D000368:Aged; D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D001424:Bacterial Infections / Q000188:drug therapy*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011552:Pseudomonas Infections / Q000188:drug therapy; D013530:Surgical Wound Infection / Q000188:drug therapy*; D014031:Tobramycin / Q000627:therapeutic use*
D000900:Anti-Bacterial Agents; D014031:Tobramycin