title: Technetium-99m-kethoxal-bis(thiosemicarbazone), an uncharged complex with a tetravalent 99mTc state, and its excretion into the bile.
abstract: Technetium-99m-kethoxal-bis (thiosemicarbazone) complex (99mTc-KTS), a potentially useful radiopharmaceutical for cholescintigraphy, is prepared by the reaction of KTS with 99mTcO4- in the presence of stannous chloride. Under the described conditions, a complex extractable with organic solvent was detected. Thin-layer chromatography, electrophoresis, and spectrometric analysis indicate the formation of an uncharged 99mTc(IV) complex. Organ distribution and biliary excretion studies are described. The complex showed a marked highly reproducible accumulation in the gallbladder.
mesh_terms: D000447:Aldehydes / Q000378:metabolism; D000818:Animals; D001646:Bile / Q000378:metabolism*; D007553:Isotope Labeling; D008297:Male; D051379:Mice; D011877:Radionuclide Imaging; D051381:Rats; D013667:Technetium; D013882:Thiosemicarbazones / Q000378:metabolism
chemical_list: D000447:Aldehydes; D013882:Thiosemicarbazones; D013667:Technetium