Effects of L-glutamine on various gastric lesions in rats and guinea pigs.
Effects of L-glutamine on gastric lesion models in rats and guinea pigs were studied. Shay ulceration in rats was not inhibited by oral L-glutamine. Although stress-induced gastric lesions in intact rats were not inhibited by L-glutamine, a strong antagonism of gastric lesions was induced in pylorus-ligated rats under the same stress by the amino acid. Histamine-induced gastric lesions in intact rats and guinea pigs were also markedly inhibited by L-glutamine. L-Glutamine inhibited the gastric lesions in rats induced by compound 48/80 but not significantly. Reserpine- or serotonin-induced gastric lesions in rats were not affected by L-glutamine. The mechanism of L-glutamine protection was discussed.
D000818:Animals; D001241:Aspirin; D004353:Drug Evaluation, Preclinical; D005973:Glutamine / Q000627:therapeutic use*; D006168:Guinea Pigs; D006632:Histamine; D008026:Ligation; D008297:Male; D011708:Pylorus / Q000502:physiology; D051381:Rats; D012110:Reserpine; D012701:Serotonin; D013276:Stomach Ulcer / Q000139:chemically induced / Q000188:drug therapy* / Q000209:etiology; D013312:Stress, Physiological / Q000150:complications; D003189:p-Methoxy-N-methylphenethylamine
D005973:Glutamine; D012701:Serotonin; D003189:p-Methoxy-N-methylphenethylamine; D006632:Histamine; D012110:Reserpine; D001241:Aspirin