Clinical study on the antifungal activity of griseofulvin in the presence of surfactants.
Scales were taken from 128 human volunteers suffering from ringworm infections and grown on Sabourand's media to determine the type of organisms causing the disease. Groups of 32 patients each were treated for sixty days with griseofulvin tablets containing dioctyl sodium sulfosuccinate, cetyl pyridinium chloride and polysorbate 80 respectively, while another group of 32 was given tablets containing griseofulvin only for the same period. The subjects treated with griseofulvin tablets containing surfactants showed a higher rate of cure than those treated with griseofulvin alone.
D000328:Adult; D002594:Cetylpyridinium / Q000627:therapeutic use; D004341:Drug Evaluation; D004357:Drug Synergism; D006118:Griseofulvin / Q000627:therapeutic use*; D006801:Humans; D011136:Polysorbates / Q000627:therapeutic use; D013501:Surface-Active Agents / Q000627:therapeutic use*; D014005:Tinea / Q000188:drug therapy*
D011136:Polysorbates; D013501:Surface-Active Agents; D006118:Griseofulvin; D002594:Cetylpyridinium