Exocrine pancreatic enzymes in cycloheximide treated rats.
Cycloheximide, even in a dose of 0.25 mg/kg administered s.c. to rats stimulated by pancreozymin and secretin, inhibited lipase activity in pancreatic juice. Lipase activity in serum of control animals was inhibited by cycloheximide. The secretion of trypsin and chymotrypsin was also decreased.
D000818:Animals; D002766:Cholecystokinin / Q000494:pharmacology; D002918:Chymotrypsin / Q000378:metabolism*; D002919:Chymotrypsinogen / Q000378:metabolism; D003513:Cycloheximide / Q000494:pharmacology*; D008049:Lipase / Q000097:blood / Q000378:metabolism*; D008297:Male; D010179:Pancreas / Q000187:drug effects / Q000201:enzymology* / Q000378:metabolism; D051381:Rats; D012633:Secretin / Q000494:pharmacology; D014357:Trypsin / Q000378:metabolism*; D014362:Trypsinogen / Q000378:metabolism
D012633:Secretin; D014362:Trypsinogen; D002766:Cholecystokinin; D002919:Chymotrypsinogen; D003513:Cycloheximide; D008049:Lipase; D002918:Chymotrypsin; D014357:Trypsin