Infection of newborn and fetal hamsters induced by inoculation of LuIII parvovirus.
The LuIII parvovirus was adapted to the newborn hamster and produced a systemic infection with massive intestinal hemorrhage. Inoculation of pregnant hamsters lead to transplacental infection of the fetuses and abortion. Most fetal deaths were observed in animals inoculated on days 8 and 10 of gestation. Virus was recovered from dead fetuses, placentas, and viable fetuses. Histological lesions were found in the heart, liver, kidney and CNS of infected fetuses.
D000818:Animals; D000831:Animals, Newborn; D006224:Cricetinae; D005260:Female; D005315:Fetal Diseases / Q000382:microbiology / Q000635:transmission*; D005333:Fetus / Q000382:microbiology; D008431:Maternal-Fetal Exchange; D009928:Organ Specificity; D010321:Parvoviridae / Q000302:isolation & purification; D010920:Placenta / Q000382:microbiology; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000382:microbiology; D014777:Virus Diseases / Q000635:transmission*