Interactions between malnutrition and primaquine studied on Wistar rats. II. Complex vitamin B deficiency and thiamine deficiency.
The action of primaquine was investigated on male Wistar rats depleted on the vitamin B complex (approximately 50% of their requirement for optimal growth), on thiamine (approximately 50% of their requirement for optimal growth), and pair-fed control animals. There was only a marginal increase in adverse primaquine reactions in the malnourished, especially in the thiamine deficient rats.
D000818:Animals; D001835:Body Weight / Q000187:drug effects; D004912:Erythrocytes / Q000201:enzymology / Q000378:metabolism; D005954:Glucosephosphate Dehydrogenase / Q000097:blood; D008099:Liver / Q000187:drug effects; D008297:Male; D008708:Methemoglobinemia / Q000378:metabolism; D009206:Myocardium; D011319:Primaquine / Q000633:toxicity*; D051381:Rats; D013832:Thiamine Deficiency / Q000097:blood / Q000201:enzymology; D014174:Transketolase / Q000097:blood; D014804:Vitamin B Deficiency / Q000097:blood / Q000201:enzymology
D005954:Glucosephosphate Dehydrogenase; D014174:Transketolase; D011319:Primaquine