Effects on venous vasomotion from the ionic content of contrast agent solutions. An investigation on microcirculation in the bat wing.
The effects on spontaneous venous vasomotion from topical application of different contrast media were investigated in the bat wing. Spontaneous venous vasomotion could be stopped either by a high osmolality of the contrast medium or by absence of cations (Na+, K+, Ca++, Mg++) in the solution. The highest contrast medium concentration (mg I/ml), which did not stop venous vasomotion, was obtained when a non-ionic contrast medium solution with low osmolality was mixed with a solution containing Na, K, Ca, Mg-salts of an ionic medium.
D000818:Animals; D002685:Chiroptera; D002712:Chlorides / Q000494:pharmacology; D003287:Contrast Media / Q000494:pharmacology*; D005950:Glucose Solution, Hypertonic / Q000494:pharmacology; D008274:Magnesium / Q000494:pharmacology; D008793:Metrizamide / Q000494:pharmacology; D008794:Metrizoic Acid / Q000494:pharmacology; D008833:Microcirculation / Q000187:drug effects*; D009119:Muscle Contraction / Q000187:drug effects; D009130:Muscle, Smooth / Q000187:drug effects*; D009994:Osmolar Concentration; D011188:Potassium / Q000494:pharmacology; D012964:Sodium / Q000494:pharmacology; D014680:Veins / Q000187:drug effects*; D014921:Wings, Animal / Q000098:blood supply
D002712:Chlorides; D003287:Contrast Media; D005950:Glucose Solution, Hypertonic; D012964:Sodium; D008794:Metrizoic Acid; D008274:Magnesium; D008793:Metrizamide; D011188:Potassium