Preparation of phase 1Q fever antigen suitable for vaccine use.
Five lots of phase 1 Q fever antigen suitable for use as vaccine were prepared utilizing the Freon-brushite method of antigen purification. Antigen concentration levels were initially adjusted turbidimetrically and later confirmed by antibody response in guinea pigs. Data showed that all lots were essentially identical in purity and antigenicity.
D000818:Animals; D000942:Antigens, Bacterial / Q000302:isolation & purification*; D001428:Bacterial Vaccines; D003381:Coxiella / Q000276:immunology*; D006168:Guinea Pigs; D006801:Humans; D008722:Methods; D011778:Q Fever / Q000517:prevention & control*
D000942:Antigens, Bacterial; D001428:Bacterial Vaccines