title: 4-nitro-2-phenoxymethanesulfonanilide (R-805): a chemically novel anti-inflammatory agent.
abstract: The anti-inflammatory activity of the sulfonanilide, 4-nitro-2-phenoxymethanesulfonanilide (R-805) has been demonstrated in conventional models (carrageenan-induced edema of the rat's paw, UV-induced erythema of guinea-pig skin, adjuvant-induced arthritis of the rat). R-805 differs from most currently available acidic anti-inflammatory drugs in that its functional acidic group is not carboxyl. The relative anti-inflammatory potency of R-805 is comparable to indomethacin. Calculation of acute therapeutic indices (LD50/ED50) for 8 acidic anti-inflammatory drugs show R-805 to possess a more favourable index than the other drugs examined.
mesh_terms: D000818:Animals; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use* / Q000633:toxicity; D001172:Arthritis, Rheumatoid / Q000188:drug therapy; D004487:Edema / Q000188:drug therapy; D004890:Erythema / Q000188:drug therapy; D007928:Lethal Dose 50; D008297:Male; D051381:Rats; D013449:Sulfonamides / Q000627:therapeutic use* / Q000633:toxicity
chemical_list: D000893:Anti-Inflammatory Agents; D013449:Sulfonamides; C012655:nimesulide