Differing estrogenic activities for the enantiomers of o, p'-DDT in immature female rats.
Female rats (20-21 days) were given single intraperitoneal injections of (+/-)-o,p'-DDT, (--)-o,p'-DDT, or (+)-o,p'-DDT. At 18 h their uteri were excised and the estrogen sensitive parameters, uterine wet weight, and uterine glycogen content were measured. For o,p'-DDT, the levo enantiomer is the more active estrogen in immature female rats. Optical resolutions of other racemic environmental xenobiotics may be important in the evaluation of their biological effects.
D000818:Animals; D003634:DDT / Q000494:pharmacology*; D004967:Estrogens; D005260:Female; D006003:Glycogen / Q000378:metabolism; D007536:Isomerism; D009929:Organ Size / Q000187:drug effects; D051381:Rats; D014599:Uterus / Q000187:drug effects* / Q000378:metabolism
D004967:Estrogens; D006003:Glycogen; D003634:DDT