[Influence of phenobarbital on the immunodepressive action of antitumor substances].
In the experiments on mice, immunized by mutton erythrocytes, the authors have studied the effect of phenobarbital, in the doses activating drug-metabolizing hepatic systems, on immunodepressive action of imurane, 6-mercaptopurine and cyclophosphane. It has been found that phenobarbital eliminates the immunodepression and reduces considerably the toxicity of the mentioned cytostatics. Under these conditions imurane and 6-mercaptopurine in certain doses render an immunostimulative instead of immunodepressive effect.
D000818:Animals; D000917:Antibody Formation / Q000187:drug effects*; D001379:Azathioprine / Q000037:antagonists & inhibitors*; D003520:Cyclophosphamide / Q000037:antagonists & inhibitors*; D004347:Drug Interactions; D007104:Immune Adherence Reaction; D015122:Mercaptopurine / Q000037:antagonists & inhibitors*; D051379:Mice; D010634:Phenobarbital / Q000494:pharmacology*; D013154:Spleen / Q000276:immunology
D003520:Cyclophosphamide; D015122:Mercaptopurine; D001379:Azathioprine; D010634:Phenobarbital
Vliianie fenobarbitala na immunodepressivnoe deĭstvie protivoopukholevykh sredstv