[The influence on the speed of epithelialisation of rabbit's eyes of IDU- and tromantadine-containing eye ointments (author's transl)].
The viro-static drugs IDU and tromantadin were tested in view of their influence on epithelial regeneration. IDU slows down the speed of epithelisation only slightly, and produces no irreversible damage in the corneal stroma, Descemet's membrane and endothelium of the rabbit eye. Tromantadin, however, slows down the speed of epithelisation quite a lot, even if the dosis is relatively small. We also found substantial changes in corneal stroma and Descemet's membrane, which have been partly recognized histologically as fibrous tissue. Application of these medicaments is recommended only if the relation between side effects and viro-static potency has been carefully rated.
D000547:Amantadine / Q000494:pharmacology*; D003886:Descemet Membrane / Q000187:drug effects*; D004848:Epithelium / Q000187:drug effects*; D006801:Humans; D007065:Idoxuridine / Q000494:pharmacology*; D009824:Ointments; D012038:Regeneration / Q000187:drug effects*
D009824:Ointments; D000547:Amantadine; D007065:Idoxuridine
Beeinflussung der Epithelisierungsgeschwindigkeit beim Kaninchenauge durch IDU- und tromantadinhaltige Augensalben