Preparation and properties of a neurotoxin purified from the venom of black widow spider (Latrodectus mactans tredecimguttatus).
A neurotoxin of the venom of the spider Latrodectus mactans tredecimguttatus, has been prepared in a homogeneous form and examined by a variety of techniques. The protein has a molecular weight of 130 000 and its toxicity in mice is about 49 000 LD50 mg pure protein/g body weight. The toxin releases norepinephrine from synaptosomes prepared from rat brain and shows most of the toxic effects of the crude venom preparation.
D000596:Amino Acids / Q000032:analysis; D000818:Animals; D001740:Black Widow Spider / Q000032:analysis*; D001921:Brain / Q000187:drug effects / Q000378:metabolism; D004837:Epinephrine / Q000378:metabolism; D007700:Kinetics; D008970:Molecular Weight; D051381:Rats; D013112:Spiders / Q000032:analysis*; D013574:Synaptosomes / Q000187:drug effects / Q000378:metabolism; D014118:Toxins, Biological / Q000302:isolation & purification / Q000494:pharmacology
D000596:Amino Acids; D014118:Toxins, Biological; D004837:Epinephrine