title: Complement component profiles in urticaria, dermatitis herpetiformis, and alopecia areata.
abstract: Insignificant variation was noted in the mean levels of the complement components CIQ, C4, C2, C3, C5 and C3PA between various groups of sera from patients with urticaria, angio-oedema, dermatitis herpetiformis, alopecia areata, or hay fever. No deficiencies were found. Elevated C9 levels in chronic urticaria and angio-oedema reflected its nature as an acute phase protein. The assessment of C components in single or sequential serum samples revealed only marginal variations. Similar results were recorded for plasminogen the immunoglobulins, G, A and M. Some evidence is provided for the primary involvement of the kallikrein-kinin system in urticaria.
mesh_terms: D000506:Alopecia Areata / Q000276:immunology*; D003172:Complement C1 / Q000032:analysis; D003175:Complement C2 / Q000032:analysis; D003176:Complement C3 / Q000032:analysis; D003181:Complement C4 / Q000032:analysis; D003182:Complement C5 / Q000032:analysis; D003186:Complement C9 / Q000032:analysis; D003165:Complement System Proteins / Q000032:analysis; D003874:Dermatitis Herpetiformis / Q000276:immunology*; D006801:Humans; D007136:Immunoglobulins / Q000032:analysis; D006255:Rhinitis, Allergic, Seasonal / Q000276:immunology; D014581:Urticaria / Q000276:immunology*
chemical_list: D003172:Complement C1; D003175:Complement C2; D003176:Complement C3; D003181:Complement C4; D003182:Complement C5; D003186:Complement C9; D007136:Immunoglobulins; D003165:Complement System Proteins