Bilateral renal calculi in patients receiving methyldopa.
Two patients with bilateral kidney stones had been taking methyldopa for 8 years and 10 years respectively. Their urine contained a brown pigment which darkened and precipitated on standing. This substance was identified as methlydopa. No other cause for stone formation was found, so it is suggested that the methyldopa, because of its poor solubility, provided a nidus for stone formation.
D000328:Adult; D005260:Female; D006801:Humans; D007669:Kidney Calculi / Q000139:chemically induced*; D008750:Methyldopa / Q000009:adverse effects*; D008875:Middle Aged
D008750:Methyldopa