A study of chromosomes of schistosomiasis patients under oxaminiquine (UK 4271) treatment.
Blood samples from 24 patients infested with Schistosoma mansoni were drawn immediately before and 2 days after the administration of a single therapeutic dose of 12-15 mg/kg oral oxaminiquine. Two-day lymphocyte cultures were obtained and about 100 mitoses from each blood sample were analyzed for chromosome aberrations. No significant differences were observed between the "before" and "after" cultures in the frequencies of aberrations resulting from spindle, chromatidic, or chromosome events. It is concluded that there is no reason to fear harmful effects on the chromosomes of patients from treatment with oxaminiquine.
D002842:Chromatids / Q000187:drug effects; D002875:Chromosomes / Q000187:drug effects*; D006801:Humans; D008214:Lymphocytes / Q000648:ultrastructure; D009600:Nitroquinolines / Q000009:adverse effects*; D010073:Oxamniquine / Q000009:adverse effects* / Q000627:therapeutic use; D012550:Schistosoma mansoni; D012552:Schistosomiasis / Q000188:drug therapy*
D009600:Nitroquinolines; D010073:Oxamniquine