[The action of pilocarpine on the metabolism of surviving lens epithelium and iris cells (author's transl)].
In tissue culture, lens epithelia and iris cells survive concentrations of 0.5 mg pilocarpine/100 ml TCM, even better those of 0.25 mg/100 ml. By means of the Warburg-method and Boehringer's Glukotest, the consumption of oxygen and glucose were measured without and with the addition of pilocarpine. The oxygen-uptake of the epithelia decreased to one third after addition of the drug, while it doubled in the iris cells. This reveals a compensating effect of the iris tissue protecting the epithelia. Pilocarpine inhibited the consumption of glucose in both tissues, but not significantly. Consequently, we are not dealing with a cataractogenuous substance. This gives new light upon Hockwin's so-called "Additions-katarakt".
D002386:Cataract / Q000139:chemically induced; D002470:Cell Survival; D002478:Cells, Cultured; D004847:Epithelial Cells; D005901:Glaucoma / Q000188:drug therapy; D006801:Humans; D007498:Iris / Q000187:drug effects / Q000378:metabolism*; D007908:Lens, Crystalline / Q000187:drug effects / Q000378:metabolism*; D010862:Pilocarpine / Q000009:adverse effects / Q000494:pharmacology*
D010862:Pilocarpine
Wirkung des Pilocarpins auf den Stoffwechsel von überlebenden Linsenepithelien und Irisgewebe