Effect of propranolol on rat brain norepinephrine in vitro.
At a 10(-5) to 10(-3) molar concentration range, 1-, d1- and d-propranolol were equipotent to progressively inhibit the uptake of 3H-NE into chopped rat cerebral cortex tissue. Similar concentrations of 1- and d1-, but not d-, propranolol significantly increased the amount of total deaminated catabolites (deaminated, deaminated-O-methylated) of 3H-NE; however, 10(-3) molar 1-, d1- and d-propranolol were required to increase the release of 3H-NE from rat brain in vitro.
D000818:Animals; D001921:Brain / Q000187:drug effects / Q000378:metabolism*; D002540:Cerebral Cortex / Q000378:metabolism; D003864:Depression, Chemical; D066298:In Vitro Techniques; D007536:Isomerism; D009638:Norepinephrine / Q000378:metabolism*; D011433:Propranolol / Q000494:pharmacology*; D051381:Rats
D011433:Propranolol; D009638:Norepinephrine