Neurobehavioral responses and drug concentrations in newborns after maternal epidural anesthesia with bupivacaine.
The neurobehavioral status of 20 newborn infants was evaluated after two to four hours of life following maternal epidural anesthesia with bupivacaine for labor and vaginal delivery. All infants were normal products of uncomplicated full-term gestations. The 20 infants, whose mothers had received continuous lumbar epidural anesthesia with bupivacaine, demonstrated no measurable difference from control infants and did not have the decrease in muscle tone and strength observed in infants whose mothers had received continuous lumbar epidural anesthesia with lidocaine or mepivacaine in a previous study.
D000767:Anesthesia, Epidural; D000773:Anesthesia, Obstetrical; D001519:Behavior / Q000187:drug effects; D001921:Brain / Q000187:drug effects; D002045:Bupivacaine / Q000097:blood; D004305:Dose-Response Relationship, Drug; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D008012:Lidocaine / Q000494:pharmacology; D008431:Maternal-Fetal Exchange; D008619:Mepivacaine / Q000494:pharmacology; D011247:Pregnancy
D008012:Lidocaine; D008619:Mepivacaine; D002045:Bupivacaine