Comparison of ocular prostaglandin synthesis inhibitors.
A comparative study was carried out of the inhibitory effect of 14 nonsteroidal anti-inflammatory compounds, administered topically, on the intraocular pressure and aqueous humor protein elevation induced by arachidonic acid in rabbits. The most effective agents were flurbiprofen solution and suspensions of indoxole (polysorbate-dispersed), meclofenamic acid, indomethacin, and clonixin.
D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology; D001082:Aqueous Humor / Q000187:drug effects / Q000378:metabolism; D001095:Arachidonic Acids / Q000009:adverse effects / Q000037:antagonists & inhibitors; D004305:Dose-Response Relationship, Drug; D005136:Eye Proteins / Q000096:biosynthesis*; D005901:Glaucoma / Q000139:chemically induced; D007429:Intraocular Pressure / Q000187:drug effects; D011448:Prostaglandin Antagonists / Q000494:pharmacology*; D011453:Prostaglandins / Q000096:biosynthesis*; D011817:Rabbits
D000893:Anti-Inflammatory Agents; D001095:Arachidonic Acids; D005136:Eye Proteins; D011448:Prostaglandin Antagonists; D011453:Prostaglandins