[Mechanism of action of nonachlazin on nervous regulation of coronary circulation].
In experiments on cats and dogs under general anesthesia nonachlazine, a new antianginal agent, depressed the reflex decrease of the blood flow to the coronary arteries (electromagnetic recording). Nonachlazine also depressed the reflex decrease of the blood flow in the system of common carotic artery, and the pressure vasomotor reflexes. During recording the tonic and reflex activity in the heart sympathetic nerves nonachlazine proved to selectively inhibit the vasoconstrictor impulses from Adelta-afferent fibers of the spinal nerves, that is it influenced the vasomotor component of the "primary" pain reaction. This mechanism could underlie the block by nonachlazine of the pain syndrome during the heart ischemia disease.
D000818:Animals; D002339:Carotid Arteries / Q000294:innervation; D002415:Cats; D003326:Coronary Circulation / Q000187:drug effects*; D003331:Coronary Vessels / Q000294:innervation*; D003864:Depression, Chemical; D004285:Dogs; D010146:Pain; D010640:Phenothiazines / Q000494:pharmacology*; D010879:Piperazines / Q000494:pharmacology*; D012018:Reflex / Q000187:drug effects*; D013127:Spinal Nerves / Q000502:physiology; D014665:Vasodilator Agents / Q000494:pharmacology; D014666:Vasomotor System / Q000187:drug effects*
D010640:Phenothiazines; D010879:Piperazines; D014665:Vasodilator Agents
O mekhanizme deĭstviia nonakhlazina na nervnuiu reguliatsiiu koronarnogo krovoobrashcheniia