title: Mutagenicity and toxicity of amitrole. II. Human lymphocyte culture tests.
abstract: Effects of amitrole (3-amino-1,2,4-triazole) on human leucocytes in culture were investigated. Amitrole interfered with lymphoblast transformation and inhibited cell growth in concentrations of 0.2% w/v and higher. Selected metaphases were examined for the presence of chromosome and chromatid aberrations. No clastogenic effects were observed.
mesh_terms: D000640:Amitrole / Q000494:pharmacology* / Q000633:toxicity; D002869:Chromosome Aberrations; D004305:Dose-Response Relationship, Drug; D005260:Female; D006801:Humans; D008213:Lymphocyte Activation / Q000187:drug effects*; D008214:Lymphocytes / Q000648:ultrastructure; D009153:Mutagens; D014230:Triazoles / Q000494:pharmacology*
chemical_list: D009153:Mutagens; D014230:Triazoles; D000640:Amitrole