[Comparative in vitro action of various antimitotic agents on cell lines established from human brain neoplasms].
The effects of six chemotherapeutic drugs currently used in human gliomas treatment were tested with an in vitro cytotoxicity test. Out of six, VM 26 proved to be the most potent against tumor cells along with a moderate cytotoxicity against normal brain or embryonnic human cells. This specificity did not seem to be related to differences in cellular growth rates.
D000970:Antineoplastic Agents / Q000494:pharmacology*; D001921:Brain / Q000166:cytology; D001932:Brain Neoplasms; D002455:Cell Division / Q000187:drug effects; D002460:Cell Line; D002478:Cells, Cultured / Q000187:drug effects*; D004622:Embryo, Mammalian / Q000166:cytology; D005910:Glioma; D006801:Humans; D066298:In Vitro Techniques; D008579:Meningioma; D013713:Teniposide / Q000494:pharmacology
D000970:Antineoplastic Agents; D013713:Teniposide
Action comparative in vitro de divers agents anti-mitotiques sur des lignées cellulaires établies ã partir de tumeurs cérébrales humaines