title: Possibility of isoproterenol therapy with soft contact lenses: ocular hypotension without systemic effects.
abstract: An experimental investigation performed in the rabbit pointed out the possibility of administering isoproterenol at low concentrations with the aid of soft contact lenses presoaked in 0.2% isoproterenol for 60 to 120 minutes. A reduction in intraocular pressure ranging from 23% to 32% was observed in 21 out of 24 glaucomatous patients. Duration of hypotension in 50% of eyes treated was more than 8 hours. Thus, a therapeutic effect was obtained with a concentration (0.2%) approximately 50 times lower than that previously employed clinically (2.4%). No systemic side effects, such as arterial hypotension and increase in heart rate, were noted.
mesh_terms: D000818:Animals; D003263:Contact Lenses, Hydrophilic; D003864:Depression, Chemical; D005901:Glaucoma / Q000188:drug therapy*; D006801:Humans; D007545:Isoproterenol / Q000008:administration & dosage* / Q000009:adverse effects / Q000627:therapeutic use; D011817:Rabbits
chemical_list: D007545:Isoproterenol