title: Enhancement of tubular organic base accumulation in renal cortical slices by repeated administrations of Tris-hydroxymethyl aminomethane, tromethamol (THAM) to rats of different ages.
abstract: After repeated THAM administrations to rats of different ages, an enhancement of THAM accumulation in renal cortical slices was observed, except in newborns. This effect can be interpreted as a specific substrate stimulation of the organic base transport system.
mesh_terms: D000367:Age Factors; D000818:Animals; D000831:Animals, Newborn; D001693:Biological Transport, Active / Q000187:drug effects; D004140:Dinitrophenols / Q000494:pharmacology; D005260:Female; D007672:Kidney Cortex / Q000378:metabolism*; D007684:Kidney Tubules / Q000378:metabolism*; D008297:Male; D009584:Nitrogen / Q000494:pharmacology; D051381:Rats; D014325:Tromethamine / Q000378:metabolism* / Q000494:pharmacology
chemical_list: D004140:Dinitrophenols; D014325:Tromethamine; D009584:Nitrogen