Tumor inhibitors. 114. Aloe emodin: antileukemic principle isolated from Rhamnus frangula L.
A systematic fractionation of an ethanol-water (1:1) extract of the seeds of Rhamnus frangula L., guided by assays for tumore-inhibitory activity, led to the isolation of aloe emodin (1). This compound was found to show significant antileukemic activity against the P-388 lymphocytic leukemia in mice. A note-worthy vehicle-dependence of the testing results is reported. In the light of this vehicle-dependence, the re-examination of other anthraquinone derivatives is recommended.
D000504:Aloe; D000818:Animals; D000880:Anthraquinones / Q000302:isolation & purification; D000972:Antineoplastic Agents, Phytogenic / Q000302:isolation & purification / Q000627:therapeutic use; D004642:Emodin / Q000031:analogs & derivatives / Q000302:isolation & purification / Q000627:therapeutic use; D007942:Leukemia, Experimental / Q000188:drug therapy; D007945:Leukemia, Lymphoid / Q000188:drug therapy*; D051379:Mice; D008517:Phytotherapy; D010946:Plants, Medicinal / Q000032:analysis*
D000880:Anthraquinones; D000972:Antineoplastic Agents, Phytogenic; C518327:aloe emodin; D004642:Emodin