[Studies on calcium absorption out of a calcium-vitamin-D-preparation using calcium-47 (author's transl)].
Calcium absorption in man was studied by means of labelling an ampoule of Frubiase Calcium forte with calcium-47. For comparative purpose a solution containing the same amount of calcium salts as the ampoule was labelled as well. Already 10 minutes after oral administration of Ca-47 in 10 ml of Frubiase Calcium forte radioactivity was statistically significant measurable in blood. At the same time there was no significant radioactivity demonstrable out of the calcium salt solution. Between 45 and 120 minutes following oral application of the isotope both groups showed a statistically significant difference concerning the measurable blood activity. The Frubiase Calcium forte values were always higher, especially one and two hours after administration of the radiocalcium (up to 40%). The levels at these times correlate well with the total calcium absorption. Measurements over the compact bone region of the ankle demonstrated significantly higher values of calcium-47 in case of Frubiase Calcium forte compared with the calcium salt solution. These findings indicate in the case of Frubiase Calcium forte a higher bone mineral accretion. There is a good direct proportionality between the amount of these values and the total calcium absorption.
D000328:Adult; D001682:Biological Availability; D001702:Biopharmaceutics; D001842:Bone and Bones / Q000378:metabolism; D002118:Calcium / Q000097:blood / Q000378:metabolism*; D002132:Calcium Radioisotopes; D004338:Drug Combinations; D004357:Drug Synergism; D005260:Female; D006801:Humans; D007408:Intestinal Absorption / Q000187:drug effects*; D008297:Male; D014807:Vitamin D / Q000494:pharmacology*
D002132:Calcium Radioisotopes; D004338:Drug Combinations; D014807:Vitamin D; D002118:Calcium
Untersuchungen mit Calcium-47 zur Calciumresorption aus einem Calcium-Vitamin-D-Kombinationspräparat