Cardiac biopsy in skeletal myopathy: report of a case with myocardial mitochondrial abnormalities.
Transvenous right ventricular endomyocardial biopsy in an 11-yr-old boy with a proximal skeletal myopathy and a cardiomyopathy, has shown a major increase in mitochondrial size and numbers on electron-microscopic morphometry, with formation of unique ring-shaped mitochondria in cardiac muscle cells. The significance of this finding and the use of cardiac biopsy in children are discussed.
D009202:Cardiomyopathies / Q000473:pathology; D002648:Child; D006003:Glycogen / Q000378:metabolism; D006801:Humans; D008297:Male; D008870:Microtubules; D008931:Mitochondria, Muscle / Q000648:ultrastructure*; D009135:Muscular Diseases / Q000473:pathology*; D009206:Myocardium / Q000378:metabolism / Q000648:ultrastructure*; D009210:Myofibrils
D006003:Glycogen