[Effect of droperidol on corticofugal influences in food motivated responses].
The influences of droperidol (butyrophenon derivative) on feeding reaction evoked by electrical stimulation of the hypothalamic "feeding centre" were investigated in unrestricted rabbits. Intravenous injection of droperidol (0.3 mg/kg) decreased the threshold of evoked feeding. Inhibitory influences of the anterior areas of the brain cortex on feeding reactions were absent in the animals under droperidol, but the facilitating influences of the posterior areas of the brain cortex on feeding reactions were retained or even became stronger. These findings are explained by dophamine-negative action of droperidol and by disturbances of the inhibitory system of the brain.
D000818:Animals; D001931:Brain Mapping; D002540:Cerebral Cortex / Q000187:drug effects*; D003864:Depression, Chemical; D004329:Droperidol / Q000494:pharmacology*; D005247:Feeding Behavior / Q000187:drug effects*; D005625:Frontal Lobe / Q000187:drug effects; D007031:Hypothalamus / Q000187:drug effects*; D009778:Occipital Lobe / Q000187:drug effects; D011817:Rabbits
D004329:Droperidol
Deĭstvie droperidola na kortikofugal'nye vliianiia v pishchevykh motivatsionnykh reaktsiiakh