Corticosteroid-induced cutaneous atrophy and telangiectasia. Experimental production associated with weight loss in rats.
A bioassay for the evaluation of certain adverse effects of various corticosteroids was performed. Twenty-eight daily topical applications of corticosteroids to young rats produced reduction in body-weight gain, atrophy of the skin as determined by double skin-fold thickness micrometer measurement, and mild to severe telangiectasia. This animal model demonstrates corticosteroid-induced skin atrophy and telangiectasia and the correlation of the degree of atrophy and telangiectasia to body-weight change. Nine corticosteroids were evaluated by this method and are listed in terms of increasing severity of side-effects as follows: 1.0% hydrocortisone cream, 0.1% betamethasone valerate cream, 0.025% betamethasone benzoate cream, 0.05% flurandrenolide cream, 0.05% fluocinonide cream, 0.1% dexamethasone cream, and 0.03% flumethasone pivalate cream. Triamcinolone acetonide cream, 0.5%, and 0.2% fluocinolone acetonide cream resulted in death of the animals prior to completion of 28 days of topical application.
D000287:Administration, Topical; D000305:Adrenal Cortex Hormones / Q000009:adverse effects*; D000818:Animals; D001284:Atrophy; D001623:Betamethasone / Q000009:adverse effects; D001835:Body Weight / Q000187:drug effects*; D003907:Dexamethasone / Q000009:adverse effects; D004195:Disease Models, Animal; D005443:Flumethasone / Q000009:adverse effects; D005446:Fluocinolone Acetonide / Q000009:adverse effects; D005447:Fluocinonide / Q000009:adverse effects; D005478:Flurandrenolone / Q000009:adverse effects; D006854:Hydrocortisone / Q000009:adverse effects; D008297:Male; D051381:Rats; D012871:Skin Diseases / Q000139:chemically induced*; D013684:Telangiectasis / Q000139:chemically induced*; D014221:Triamcinolone / Q000009:adverse effects
D000305:Adrenal Cortex Hormones; D005446:Fluocinolone Acetonide; D014221:Triamcinolone; D005447:Fluocinonide; D003907:Dexamethasone; D005478:Flurandrenolone; D001623:Betamethasone; D005443:Flumethasone; D006854:Hydrocortisone