Further studies on the histological cytological and cytogenetic effects of nogalamycin in mammals.
The histological, cytological and cytogenetic effects of nogalamycin were studied in rats, mice and cultured human leukocytes. Four standard test systems were used in the cytological studies: (1)analysis of spermatogonial cells, (2)cytological evaluation of bone marrow metaphase plates, (3)micronucleus test in polychromatic erythrocytes, and (4)determination of chromosomal aberrations in cultured human leukocytes. The results of the studies indicated that the types and frequenices of cytological errors induced by the drug were not significantly different from the concurrent control. The reduced incidence of fertile matings from 22 to 35 days after treatment is attributed to the cytostatic effect of nogalamycin (NM) on spermatogonia and spermatocytes. Subsidence of NM-induced inhibition of spermatogonium differentiation and spermatocyte maturation occurred 37 days post-treatment. Accordingly, fertile matings, which had reached a zero level by 23rd day, occurred 35 days after treatment, and reached the control level between 47 and 49 days post-treatment.
D000818:Animals; D001853:Bone Marrow / Q000648:ultrastructure; D001854:Bone Marrow Cells; D002869:Chromosome Aberrations; D005260:Female; D006801:Humans; D007274:Injections, Intraperitoneal; D008213:Lymphocyte Activation / Q000187:drug effects*; D008297:Male; D009153:Mutagens; D009279:Naphthacenes / Q000494:pharmacology*; D009621:Nogalamycin / Q000008:administration & dosage / Q000494:pharmacology*; D013045:Species Specificity; D013090:Spermatocytes / Q000187:drug effects; D013091:Spermatogenesis / Q000187:drug effects*
D009153:Mutagens; D009279:Naphthacenes; D009621:Nogalamycin