Value of lymphoblast transformation test in cow's milk protein intestinal intolerance.
Lymphoblast transformation tests were carried out in the presence of alpha-lactalbumin and beta-lactoglobulin. In patients with cow's milk protein intestinal intolerance in seventeen of forty-five (37.8%) the lymphoblast transformation tests were positive. Sensitization in the first month of life seemed to favour lymphoblast transformation. In control children in only four of forty-three (9.5%) the lymphoblast transformation tests were positive, the difference from intolerant patients being significant 0.01 less than P less than 0.001. Lymphoblast transformation tests were negative in the seven children with active coeliac disease. Although a negative test does not exclude cow's milk protein intolerance, lymphoblast transformation tests can be considered a useful aid in diagnosis because of its specificity.
D000485:Allergens; D000818:Animals; D002417:Cattle; D002675:Child, Preschool; D005260:Female; D006801:Humans; D006967:Hypersensitivity / Q000175:diagnosis*; D007223:Infant; D007410:Intestinal Diseases / Q000175:diagnosis* / Q000276:immunology; D008213:Lymphocyte Activation; D008297:Male; D008894:Milk Proteins / Q000276:immunology*
D000485:Allergens; D008894:Milk Proteins