[Comparison of lipid concentrations in lung homogenates of newborns with and without hyaline membrane disease (author's transl)].
Quantitative and qualitative studies on lipids of the lungs were performed in babies who died during the perinatal period. The lungs were divided into organs with and without hyaline membranes respectively. Total lipids, phospholipids, neutral lipids, lecithins and sphingomyelins were determined. The fatty acid composition of total phospholipids and of lecithins is reported. A multivariate analysis of variance was used for the verification of significant differences in lipid content and in fatty acid composition with regard to the histological diagnosis. Taking at least two parameters (total phospholipids and C: 14-fatty acid or lecithin and C: 14-fatty acid into account, the two groups (lungs with and without hyaline membranes) were significantly different at the 5% level. The results are compared as well with the lipid content and composition of fatty acids of normal neonatal lung tissue as with observations regarding the lipids in amniotic fluid. The data obtained are discussed with regard to the development of lung maturity.
D000653:Amniotic Fluid / Q000032:analysis; D000704:Analysis of Variance; D005227:Fatty Acids / Q000032:analysis; D005260:Female; D006651:Histocytochemistry; D006801:Humans; D006819:Hyaline Membrane Disease / Q000378:metabolism* / Q000473:pathology; D007231:Infant, Newborn; D008055:Lipids / Q000032:analysis*; D008168:Lung / Q000032:analysis*; D009227:Myristic Acids / Q000032:analysis; D010713:Phosphatidylcholines / Q000032:analysis; D010743:Phospholipids / Q000032:analysis; D011247:Pregnancy; D013109:Sphingomyelins / Q000032:analysis
D005227:Fatty Acids; D008055:Lipids; D009227:Myristic Acids; D010713:Phosphatidylcholines; D010743:Phospholipids; D013109:Sphingomyelins
Vergleichende Untersuchungen der Lipide mit Darstellung des Fettsäuremusters der Gesamtphosphatide und des Lecithins im Lungengewebe postpartal an einem Atemnotsyndrom verstorbener Neugeborener