[Interaction of tricyclic antidepressants with noradrenaline and 5-hydroxytryptamine in peripheral preparations of the rat].
The potentiation of the noradrenaline (NA) actions by antidepressant drugs was studied in vitro on the rat vas deferens and in vivo on the rat blood pressure. A new dibenzazepine compound, LM 208, and two antiparkinsonian drugs, orphenadrine and its demethylated derivative, were compared to well known antidepressants. The modification by all these agents of the rat uterus response to 5-hydroxytryptamine (5-HT) was also investigated. The possible use of these interactions as models for NA and 5-HT uptake inhibition is discussed.
D000818:Animals; D000929:Antidepressive Agents, Tricyclic / Q000494:pharmacology*; D001794:Blood Pressure / Q000187:drug effects; D004347:Drug Interactions; D004357:Drug Synergism; D005260:Female; D066298:In Vitro Techniques; D008297:Male; D009119:Muscle Contraction / Q000187:drug effects; D009130:Muscle, Smooth / Q000187:drug effects; D009638:Norepinephrine / Q000494:pharmacology*; D051381:Rats; D012701:Serotonin / Q000494:pharmacology*; D012702:Serotonin Antagonists; D014599:Uterus / Q000187:drug effects; D014649:Vas Deferens / Q000187:drug effects
D000929:Antidepressive Agents, Tricyclic; D012702:Serotonin Antagonists; D012701:Serotonin; D009638:Norepinephrine
Interaction des antidépresseurs tricycliques avec la noradrénaline et la 5-hydroxytryptamine sur des préparations périphériques chez le rat