Effect of hydrocortisone 17-butyrate on the percutaneous absorption of antibiotics.
Abrption of antibiotics from combined preparations containing oxytetracycline, chlortetracycline, doxycycline or gentamicin and hydrocortisone 17-butyrate into the skin of rats was examined. The penetration of antibiotics from the ointment into the skin was inhibited by 0.2% hydrocortisone 17-butyrate to a significant degree. It is suggested that this effect of hydrocortisone 17-butyrate is the consequence of its vasoconstrictor action.
D000287:Administration, Topical; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology*; D002751:Chlortetracycline / Q000008:administration & dosage / Q000378:metabolism*; D003864:Depression, Chemical; D004318:Doxycycline / Q000008:administration & dosage / Q000378:metabolism*; D005839:Gentamicins / Q000008:administration & dosage / Q000378:metabolism*; D006854:Hydrocortisone / Q000031:analogs & derivatives*; D009824:Ointments; D010118:Oxytetracycline / Q000008:administration & dosage / Q000378:metabolism*; D051381:Rats; D012867:Skin / Q000378:metabolism*
D000893:Anti-Inflammatory Agents; D005839:Gentamicins; D009824:Ointments; D004318:Doxycycline; D002751:Chlortetracycline; D006854:Hydrocortisone; D010118:Oxytetracycline