title: Some examples of dose-response studies in chemical carcinogenesis.
abstract: Three studies of DRUCKREY and his group, on diethylnitrosamine and 4-dimethylaminostilbene, are described. In a recent experiment, urethane was given chronically to rats and mice, at doses between 100 and 12,500 mug/kg/day. The results in rats were evaluated with the Mantel-Bryan procedure; risk estimates greatly differed, depending on the slope used for calculation.
mesh_terms: D000818:Animals; D004052:Diethylnitrosamine; D004305:Dose-Response Relationship, Drug; D051379:Mice; D009374:Neoplasms, Experimental / Q000139:chemically induced*; D009602:Nitrosamines; D051381:Rats; D012306:Risk; D013267:Stilbenes; D013997:Time Factors; D014520:Urethane
chemical_list: D009602:Nitrosamines; D013267:Stilbenes; C007466:4-dimethylaminostilbene; D014520:Urethane; D004052:Diethylnitrosamine