On the role of serotonin in the pathogenesis of pulmonary hypertension induced by anorectic drugs; an experimental study in the isolated perfused rat lung, II. Fenfluramine, mazindol, mefenorex, phentermine and R 800.
1. The influence of the anorectic drugs fenfluramine, mazindol, mefenorex, phentermine and R 800, an experimental compound, on pulmonary vascular resistance has been studied in the isolated, perfused rat lung. 2. R 800 caused a strong vasoconstriction, which was not antagonized by methysergide of phentolamine; the other drugs listed did not alter vascular resistance. 3. Mazindol and phentermine significantly prolonged the vasoconstrictive effect of serotonin due to inhibition of its metabolic breakdown. 4. Although fenfluramine inhibited serotonin metabolism it also prevented the vasoconstrictive effect of serotonin, due to its ability to act as a serotonin antagonist. 5. Mefenorex did not affect pulmonary vascular resistance, either directly or indirectly via a serotoninergic mechanism.
D000662:Amphetamines; D000818:Animals; D001067:Appetite Depressants / Q000494:pharmacology*; D002839:Chromans; D004347:Drug Interactions; D005277:Fenfluramine / Q000494:pharmacology; D006976:Hypertension, Pulmonary / Q000139:chemically induced*; D066298:In Vitro Techniques; D008168:Lung / Q000187:drug effects*; D008454:Mazindol / Q000494:pharmacology; D010477:Perfusion; D010627:Phenethylamines / Q000494:pharmacology; D010645:Phentermine / Q000494:pharmacology; D051381:Rats; D012701:Serotonin / Q000378:metabolism / Q000502:physiology*; D013997:Time Factors
D000662:Amphetamines; D001067:Appetite Depressants; D002839:Chromans; D010627:Phenethylamines; D005277:Fenfluramine; D012701:Serotonin; D010645:Phentermine; C012654:fenisorex; D008454:Mazindol; C000450:mefenorex