title: [Cytocarcinogenesis of the rat hepatoma induced by N-nitrosomorpholine].
abstract: In experiments carried out on Wistar rats ultrastructrual charges of hepatocytes were studied during long-term carcinogenesis due to N-Nitrosomorpholine administered as a 20 mg% solution in drinking water. Carcinoma usually developed after the 20th week of the experiment. The development of the tumour was preceded by early dystrophic changes and, later, by a precancerous posttoxic "glycogenosis". The structural alterations as observed during the precancerous stage were rather noncharacteristic so that they did not permit to disclose the exact point of neoplastic change of the hepatocytes. Nevertheless, the model of carcinogenesis as demonstrated here appears to be a rather standard one and seems to be suitable for studying oncological problems of general character.
mesh_terms: D000818:Animals; D002273:Carcinogens; D002471:Cell Transformation, Neoplastic / Q000187:drug effects*; D004721:Endoplasmic Reticulum; D008113:Liver Neoplasms / Q000139:chemically induced / Q000473:pathology*; D008930:Mitochondria, Liver; D008938:Mitosis; D009025:Morpholines / Q000009:adverse effects*; D009603:Nitroso Compounds / Q000009:adverse effects; D051381:Rats
chemical_list: D002273:Carcinogens; D009025:Morpholines; D009603:Nitroso Compounds
vernacular_title: Cytokarcinogeneze hepatomu krysy vyvolaného N-nitrózomorfolinem