Mianserin hydrochloride: a novel antidepressant.
The antidepressant activities of mianserin hydrochloride were investigated and compared with those of amitriptyline. The therapeutic efficacy of the two drugs appeared similar, but the incidence of side-effects was significantly higher with amitriptyline. Plasma levels of mianserin were determined during the trial and were not related to the therapeutic activity of the drug.
D000275:Adjustment Disorders / Q000188:drug therapy; D000639:Amitriptyline / Q000009:adverse effects / Q000097:blood / Q000627:therapeutic use; D003863:Depression / Q000188:drug therapy*; D003984:Dibenzazepines / Q000627:therapeutic use*; D004341:Drug Evaluation; D005260:Female; D006801:Humans; D008297:Male; D008803:Mianserin / Q000009:adverse effects / Q000097:blood / Q000627:therapeutic use*; D008875:Middle Aged; D013997:Time Factors
D003984:Dibenzazepines; D000639:Amitriptyline; D008803:Mianserin