Evaluation of the humoral immune response of children with low lead exposure.
Twelve lead-exposed children, with evidence of metabolic impairment, and seven non-lead exposed children were examined for evidence of impairment of their immunological response. There were no differences between the control group and the lead exposed group with reference to complement levels, immunoglobulins, or anamnestic response to the tetanus toxoid antigen. It remains to be demonstrated whether or not there is deficient response to primary immunization, whether other antigens are more affected by lead, or whether impairment of humoral immune response requires a more serious degree of lead intoxication.
D002648:Child; D002675:Child, Preschool; D003176:Complement C3 / Q000032:analysis; D003165:Complement System Proteins / Q000032:analysis; D006801:Humans; D007109:Immunity / Q000187:drug effects*; D007070:Immunoglobulin A / Q000032:analysis; D007074:Immunoglobulin G / Q000032:analysis; D007075:Immunoglobulin M / Q000032:analysis; D007136:Immunoglobulins / Q000032:analysis; D007854:Lead / Q000494:pharmacology*; D013743:Tetanus Antitoxin / Q000032:analysis; D013745:Tetanus Toxoid / Q000494:pharmacology
D003176:Complement C3; D007070:Immunoglobulin A; D007074:Immunoglobulin G; D007075:Immunoglobulin M; D007136:Immunoglobulins; D013743:Tetanus Antitoxin; D013745:Tetanus Toxoid; D007854:Lead; D003165:Complement System Proteins