Piromidic acid and its ethylic ester: absorption, distribution, excretion.
The absorption, distribution and excretion of piromidic acid and its ethyl ester were investigated in the rat. When administered orally the ethyl ester was well absorbed and subsequently hydrolysed, giving much higher blood and tissue concentration than a corresponding dose of the parent compound. The antimicrobial activity of urine and bile samples was also investigated.
D000818:Animals; D055598:Chemical Phenomena; D002621:Chemistry; D007408:Intestinal Absorption; D009539:Nicotinic Acids / Q000378:metabolism*; D011759:Pyrrolidines / Q000378:metabolism*; D051381:Rats
D009539:Nicotinic Acids; D011759:Pyrrolidines