[The effect of vinblastine on DNA metabolism in turnover cells (author's transl)].
Studies on the effect of Vinblastine on normal and tumour cell show that semi-conservative DNA synthesis correlates with the enzymatic activity of thymidine kinase. DNA repair investigations performed with Yoshida-Ascites cells indicate an inhibitory effect on the ligase system after Vinblastine treatment and gamma irradiation.
D000818:Animals; D001943:Breast Neoplasms / Q000378:metabolism / Q000473:pathology; D002478:Cells, Cultured; D004260:DNA Repair / Q000187:drug effects; D004273:DNA, Neoplasm / Q000378:metabolism*; D005260:Female; D006801:Humans; D051381:Rats; D012517:Sarcoma, Yoshida / Q000201:enzymology / Q000378:metabolism / Q000473:pathology; D014747:Vinblastine / Q000494:pharmacology*
D004273:DNA, Neoplasm; D014747:Vinblastine
Uber den Einfluss von Vinblastin auf den DNA-Stoffwechsel in Tumorzellen