Resistance of purified cholera toxin to enzymatic treatment with pancreatic elastase and papain.
Treatment of Cholera toxin with pancreatic elastase and papain in vitro showed a high resistance of the toxin molecule to these enzymes, under non-denaturing conditions or in the presence of 2 M urea. These experiments support the hypothesis of a particularly stable molecular structure of the toxin, as an explanation of its activity in the intestinal lumen where the pancreatic proteases are active.
D010196:Pancreatic Elastase / Q000378:metabolism; D010206:Papain / Q000378:metabolism; D014118:Toxins, Biological / Q000378:metabolism*; D014508:Urea; D014734:Vibrio cholerae
D014118:Toxins, Biological; D014508:Urea; D010196:Pancreatic Elastase; D010206:Papain