The glycerylphosphorylcholine content of the rat epididymis after injecting alpha-chlorohydrin and ligating the vasa efferentia.
The concentration of GPC in the 4 segments (initial segment, caput, corpus and cauda) of the rat epididymis was examined at various times (4 hours. 2, 5, 10 and 20 days) following injection of a lesion-forming dose (90 mg/kg body weight) of alpha-chlorohydrin and bilateral ligation of the vasa efferentia. There was a reduction in the overall GPC concentration of the epididymis 2 days after both treatments and a further decrease until 20 days when a slight increase occurred. It is suggested that a lesion-forming dose of alpha-chlorohydrin, like ligation of the vasa efferentia, could inhibit the synthesis and/or release of GPC within the epididymis by blocking off androgen supply in the testicular fluid.
D000818:Animals; D002728:Chlorohydrins / Q000494:pharmacology*; D004822:Epididymis / Q000187:drug effects / Q000378:metabolism*; D005997:Glycerylphosphorylcholine / Q000096:biosynthesis*; D008026:Ligation; D008297:Male; D051381:Rats; D012671:Seminiferous Tubules / Q000601:surgery*; D013737:Testis / Q000601:surgery*; D013739:Testosterone / Q000378:metabolism; D013997:Time Factors
D002728:Chlorohydrins; D013739:Testosterone; D005997:Glycerylphosphorylcholine