title: Localized mutagenesis in Streptomyces coelicolor A3 (2).
abstract: Nutritional mutants (co-mutants) were scored among nitrosoguanidine-induced revertants of four mutations in Streptomyces coelicolor A3 (2). All co-mutations were due to mutations in genes linked to the revertant locus. The co-mutant loci were located in a region of about 20 map units around the revertant locus (co-mutation region). Revertants for different loci showed co-mutation patterns different from each other and from that of random nitrosoguanidine-induced forward mutations. Mutations appeared to be completely abolished outside the co-mutation region (mutation restriction).
mesh_terms: D002467:Cell Nucleus; D002874:Chromosome Mapping; D002875:Chromosomes; D005809:Genes, Regulator; D008040:Genetic Linkage; D006579:Heterozygote; D006639:Histidine / Q000378:metabolism; D008769:Methylnitronitrosoguanidine / Q000494:pharmacology*; D009153:Mutagens; D009154:Mutation / Q000187:drug effects*; D009604:Nitrosoguanidines / Q000494:pharmacology*; D013302:Streptomyces / Q000166:cytology / Q000378:metabolism*
chemical_list: D009153:Mutagens; D009604:Nitrosoguanidines; D008769:Methylnitronitrosoguanidine; D006639:Histidine