Immunoglobinuria in the acute phase of viral hepatitis in children and the influence of HBAg antigen.
Urinary excretion of immunoglobulins of the A, G and M classes was studied in 14 children suffering from viral hepatitis without HBAg antigenemia, and in 12 children with viral hepatitis accompanied by HBAg antigenemia. The control group consisted of 11 healthy children. Over fourfold increase in excretion of IgA, and only twofold increase in IgG were observed. The difference in excretion of A and G immunoglobulins, despite their similar molecular weight, was attributed to increased active excretion of IgA by the kidneys, probably due to stimulation by the virusemia. In no case were immunoglobulins of the M class encountered in the urine.
D000208:Acute Disease; D000367:Age Factors; D002648:Child; D002675:Child, Preschool; D006506:Hepatitis A / Q000652:urine*; D006511:Hepatitis B Antigens / Q000032:analysis*; D006801:Humans; D007070:Immunoglobulin A / Q000652:urine; D007074:Immunoglobulin G / Q000652:urine; D007136:Immunoglobulins / Q000652:urine*
D006511:Hepatitis B Antigens; D007070:Immunoglobulin A; D007074:Immunoglobulin G; D007136:Immunoglobulins