Metabiolic products of microorganisms. Tirandamycin B(author's transl).
Streptomyces flaveolus, strain Tü 1240 produces besides Tirandamycin A, a hitherto unknown antibiotic, which is closely related to Tirandamycin A. The new antibiotic Tirandamycin B contains one additional hydroxylgroup. Both antibiotics exhibit a similar antimicrobial spectrum and they seem to have the same mechanism of action. According to the data obtained from mass spectrometry, 13C-and 1H-NMR spectra formula II could be deduced for Tirandamycin B.
D000617:Aminoglycosides; D000900:Anti-Bacterial Agents / Q000096:biosynthesis / Q000494:pharmacology; D001419:Bacteria / Q000187:drug effects; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D012321:DNA-Directed RNA Polymerases / Q000037:antagonists & inhibitors; D005285:Fermentation; D008826:Microbial Sensitivity Tests; D008968:Molecular Conformation; D011760:Pyrrolidinones / Q000096:biosynthesis / Q000494:pharmacology; D012329:RNA, Bacterial / Q000096:biosynthesis; D013302:Streptomyces / Q000378:metabolism
D000617:Aminoglycosides; D000900:Anti-Bacterial Agents; D011760:Pyrrolidinones; D012329:RNA, Bacterial; C003608:tirandamycin A; C021492:tirandamycin B; D012321:DNA-Directed RNA Polymerases
Stoffwechselprodukte von Mikroorganismen. 158. Mitteilung. Tirandamycin B.