Destruction of the endolymphatic sac in the cat.
The endolymphatic duct and sac were destroyed by drilling in a cat that was sacrificied after 2 3/4 years. Histological examination of the temporal bones showed marked endolymphatic hydrops; degeneration of the stria vascularis in the upper coil; degeneration of the organ of Corti and spiral ganglion in the upper and middle coils; and degeneration of the macula of the saccule. It is probable that, in some cases at least, the primary pathology of Menière's disease is in the endolymphatic sac.
D000818:Animals; D002415:Cats; D007758:Ear, Inner / Q000473:pathology; D004487:Edema / Q000209:etiology / Q000473:pathology; D004710:Endolymph; D007759:Labyrinth Diseases / Q000150:complications*; D009925:Organ of Corti / Q000473:pathology; D012444:Saccule and Utricle / Q000473:pathology; D013997:Time Factors