Changes in hepatic fatty acid degradation and blood lipid and ketone body content during development of the rat.
The following have been measured during the development of the laboratory rat: the rate of oxidation of palmitoylcarnitine, decanoylcarnitine, and 14C-palmitate by liver mitochondria; the concentrations of ketone bodies in the blood; the plasma concentrations of non-esterified fatty acids, glycerol, and triglyceride. In each case, a rise after birth and a fall at weaning were observed. These changes can be correlated with the dietary changes which occur at these times. However, during the suckling period, when a constant high fat content diet is consumed, further marked changes in the parameters measured were observed which cannot be related to nutritional factors.
D000367:Age Factors; D000818:Animals; D000831:Animals, Newborn; D002331:Carnitine / Q000031:analogs & derivatives / Q000378:metabolism; D005227:Fatty Acids / Q000378:metabolism*; D005230:Fatty Acids, Nonesterified / Q000097:blood; D005260:Female; D005333:Fetus / Q000378:metabolism; D005990:Glycerol / Q000097:blood; D007657:Ketone Bodies / Q000097:blood*; D008055:Lipids / Q000097:blood*; D008930:Mitochondria, Liver / Q000378:metabolism*; D010168:Palmitates / Q000378:metabolism; D011247:Pregnancy; D051381:Rats; D014280:Triglycerides / Q000097:blood
D005227:Fatty Acids; D005230:Fatty Acids, Nonesterified; D007657:Ketone Bodies; D008055:Lipids; D010168:Palmitates; D014280:Triglycerides; D005990:Glycerol; D002331:Carnitine