[Lactic acidosis and biguanid therapy (author's transl)].
Ten case histories of patients with lactic acidosis and biguanide therapy are presented. 6 patients received phenformin, 4 buformin. The symptomatology was characterized by somnolence or unconsciousness with hyperventilation, renal insufficiency, signs of infection occasionally with detection of gram negative rods and in later stages circulatory insufficiency with high central venous pressure. Glucose, insulin, bicarbonate, dialysis, antibiotics and katecholamines were the therapeutic measurements. It is the proposal of this communication to call attention again to the potential toxicity of biguanids which makes necessary the strict observation of contraindications.
D000138:Acidosis / Q000139:chemically induced* / Q000150:complications / Q000628:therapy; D000368:Aged; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D001639:Bicarbonates / Q000627:therapeutic use; D001645:Biguanides / Q000009:adverse effects* / Q000627:therapeutic use; D002021:Buffers; D002026:Buformin / Q000009:adverse effects; D003920:Diabetes Mellitus / Q000188:drug therapy; D005260:Female; D005947:Glucose / Q000627:therapeutic use; D006801:Humans; D007049:Iatrogenic Disease; D007328:Insulin / Q000627:therapeutic use; D007773:Lactates / Q000097:blood*; D008297:Male; D008875:Middle Aged; D010629:Phenformin / Q000009:adverse effects; D006435:Renal Dialysis; D014552:Urinary Tract Infections / Q000150:complications
D000900:Anti-Bacterial Agents; D001639:Bicarbonates; D001645:Biguanides; D002021:Buffers; D007328:Insulin; D007773:Lactates; D010629:Phenformin; D005947:Glucose; D002026:Buformin
Biguanidtherapie und Lactatacidose