Metiamide inhibits canine gastric acid secretion evoked by sham feeding.
A continuous intravenous infusion of metiamide markedly inhibited the gastric acid secretory response to sham feeding in two dogs provided with Pavlov pouches and gastric fistulae. The results show that an antagonist of histamine H2-receptors is capable of inhibiting a vagally activated secretion evoked by sham feeding, which may be considered a physiological vagal stimulus.
D000818:Animals; D003864:Depression, Chemical; D004285:Dogs; D005750:Gastric Juice / Q000378:metabolism*; D005753:Gastric Mucosa / Q000378:metabolism*; D008785:Metiamide / Q000494:pharmacology*; D012636:Secretory Rate / Q000187:drug effects; D013270:Stomach / Q000502:physiology; D013890:Thiourea / Q000031:analogs & derivatives*; D014630:Vagus Nerve / Q000502:physiology
D008785:Metiamide; D013890:Thiourea