title: Heritable chromosome aberrations in mammals after exposure to chemicals.
abstract: The observation of dividing spermatocytes is routinely used to detect the induction of heritable chromosome aberrations such as reciprocal translocations in the treated animals or in their F1 offspring. 37 compounds have so far been tested for the induction of chromosome rearrangements in spermatogonia. Only 9 gave positive results. However, positive results were observed for all alkylating agents in the F1 test. From these observations it can be concluded that the spermatogonia which are the main germ cell type at risk represent a relatively safe germ cell stage.
mesh_terms: D000348:Aflatoxins; D000477:Alkylating Agents; D000634:Aminoquinolines; D000818:Animals; D000962:Antimalarials; D002110:Caffeine; D002869:Chromosome Aberrations; D003494:Cyclamates; D003543:Cysteamine; D004006:Dichlorvos; D004996:Ethidium; D006826:Hycanthone; D007306:Insecticides; D007538:Isoniazid; D008238:Lysergic Acid Diethylamide; D008297:Male; D008463:Mebendazole; D008670:Metals; D008937:Mitomycins; D009153:Mutagens; D010653:Phenylbutazone; D013093:Spermatogonia / Q000187:drug effects*; D013094:Spermatozoa / Q000187:drug effects*; D013307:Streptomycin; D014178:Translocation, Genetic; D000338:beta-Aminoethyl Isothiourea
chemical_list: D000348:Aflatoxins; D000477:Alkylating Agents; D000634:Aminoquinolines; D000962:Antimalarials; D003494:Cyclamates; D007306:Insecticides; D008670:Metals; D008937:Mitomycins; D009153:Mutagens; D000338:beta-Aminoethyl Isothiourea; D006826:Hycanthone; D002110:Caffeine; D003543:Cysteamine; D004006:Dichlorvos; D008463:Mebendazole; D008238:Lysergic Acid Diethylamide; D004996:Ethidium; D010653:Phenylbutazone; D007538:Isoniazid; D013307:Streptomycin