title: [Metabolism of essential and endogenous serum fatty acids in healthy persons, coronary disease and patients with lipid metabolism disorder. Partial aspect of high risk problem patients with age-related lipid and fatty acid concentrations in serum and regulation of long-chain products from essential and endogenous precursors in healthy subjects].
abstract: Total lipid, free and esterified cholesterol and triglycerides significantly increase in concentration with increasing age. Palmitic, palmitoleic, oleic and linoleic acid behave in the same way. Free fatty acids, phospholipids and stearic acid show the same concentrations in all groups of age. C20 fatty acids demonstrate a competitive regulatory mechanism of desaturase activity in their age dependant distribution. While the 20:3(n-9), a product of the endogenous (n-9) family, increases, the 20:3(n-6) and 20:4(n-6), both desaturation and chain elongation products of the essential n-6 family, decrease. Such behavior has been demonstrated in many feeding studies (12, 13, 15, 16, 17, 29) and is interpreted as a result of competitive substrate interaction on desaturase activity.
mesh_terms: D015126:8,11,14-Eicosatrienoic Acid / Q000097:blood; D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000368:Aged; D001095:Arachidonic Acids / Q000097:blood; D002648:Child; D002675:Child, Preschool; D002784:Cholesterol / Q000097:blood; D005227:Fatty Acids / Q000097:blood*; D005230:Fatty Acids, Nonesterified / Q000097:blood; D006801:Humans; D007223:Infant; D008041:Linoleic Acids / Q000097:blood; D008055:Lipids / Q000097:blood*; D008297:Male; D008875:Middle Aged; D009829:Oleic Acids / Q000097:blood; D010169:Palmitic Acids / Q000097:blood; D010743:Phospholipids / Q000097:blood; D012306:Risk; D013229:Stearic Acids / Q000097:blood; D014280:Triglycerides / Q000097:blood
chemical_list: D001095:Arachidonic Acids; D005227:Fatty Acids; D005230:Fatty Acids, Nonesterified; D008041:Linoleic Acids; D008055:Lipids; D009829:Oleic Acids; D010169:Palmitic Acids; D010743:Phospholipids; D013229:Stearic Acids; D014280:Triglycerides; D002784:Cholesterol; D015126:8,11,14-Eicosatrienoic Acid
vernacular_title: Zum Stoffwechsel essentieller und endogener Serumfettsäuren bei Gesunden, Koronarsklerotikern und Patienten mit Fettstoffwechselstörungen. Ein Teilaspekt des Risikofaktorenproblems. 1. Mitteilung: Altersabhängigkeit der Lipid- und Fettsäurekonzentrationen des Serums und Regulation der langkettigen Produkte aus essentiellen und endogenen Precursoren bei gesunden Probanden