Endogenous motilin and lower esophageal sphincter pressure in man: clue to an association.
In man (n = 5), after intraduodenal instillation of 50 ml of 0.1 N hydrochloric acid the lower esophageal sphincter pressure (LESP) and plasma motilin concentrations rise concomitantly exceeding basal by about 80% (p less than 0.025) and 90% (p less than 0.05), respectively, at 3 to 4 minutes. These results suggest that the increase in LESP after duodenal acidification may be brought about by endogenously released motilin.
D000328:Adult; D004386:Duodenum; D004943:Esophagogastric Junction / Q000187:drug effects / Q000502:physiology*; D005768:Gastrointestinal Hormones / Q000502:physiology*; D005769:Gastrointestinal Motility / Q000187:drug effects*; D006801:Humans; D006851:Hydrochloric Acid / Q000008:administration & dosage / Q000494:pharmacology; D008297:Male; D008365:Manometry
D005768:Gastrointestinal Hormones; D006851:Hydrochloric Acid