Barbital alteration of central nervous system sensitivity to hexobarbital in the rat.
Alteration in central nervous system (CNS) sensitivity to the hypnotic effect of the hexobarbital was assessed by analytical, electroencephalographic, and pharmacokinetic techniques in barbital-treated rats. Each of these conceptually diverse experimental methodologies yielded similar conclusions concerning the alteration of CNS sensitivity by barbital treatment.
D000818:Animals; D001462:Barbital / Q000494:pharmacology*; D001463:Barbiturates / Q000494:pharmacology*; D001921:Brain / Q000378:metabolism; D002490:Central Nervous System / Q000187:drug effects*; D004361:Drug Tolerance; D004569:Electroencephalography; D006591:Hexobarbital / Q000378:metabolism / Q000494:pharmacology*; D007700:Kinetics; D008099:Liver / Q000378:metabolism; D008297:Male; D051381:Rats; D012890:Sleep / Q000187:drug effects
D001463:Barbiturates; D001462:Barbital; D006591:Hexobarbital