Experiences with physostigmine in the reversal of adverse post-anaesthetic effects.
Physostigmine salicylate has proved to be a very useful agent for use in the recovery room. All but two of our first 110 patients receiving it were returned to full consciousness, whether they had been comatose or agitated. In our hands it has been used to reverse the adverse central effects of tranquilizers, antihistamines and belladonna alkaloids.
D000293:Adolescent; D000328:Adult; D000368:Aged; D001285:Atropine / Q000037:antagonists & inhibitors; D001533:Belladonna Alkaloids / Q000037:antagonists & inhibitors*; D055598:Chemical Phenomena; D002621:Chemistry; D003243:Consciousness / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009949:Orientation / Q000187:drug effects; D010830:Physostigmine / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D011182:Postoperative Care; D012601:Scopolamine / Q000037:antagonists & inhibitors; D014149:Tranquilizing Agents / Q000037:antagonists & inhibitors
D001533:Belladonna Alkaloids; D014149:Tranquilizing Agents; D001285:Atropine; D010830:Physostigmine; D012601:Scopolamine