title: The urethral closure pressure profile. A new technique using gas and simultaneous EMG-recording from the urethra.
abstract: A new technique for recording of the urethral closure pressure profile using gas-inflation and simultaneous EMG-recording from the urethra is described. With the present technique, the parameters of the urethral closure pressure profile in healthy volunteers were in accordance with previous reports using water-infusion. The effect of alpha-adrenergic blockade on the pressure profile was studied in a series of patients. Half of the patients showed a marked reduction of the intraurethral pressure in the presphincteric part of the profile after alpha-adrenergic blockade. This indicated that sympathetic innervated smooth musculature gives a significant contribution to the total intraurethral pressure.
mesh_terms: D002245:Carbon Dioxide; D004576:Electromyography / Q000379:methods*; D005260:Female; D006801:Humans; D008297:Male; D010646:Phentolamine / Q000494:pharmacology; D011312:Pressure; D014521:Urethra / Q000187:drug effects / Q000502:physiology*
chemical_list: D002245:Carbon Dioxide; D010646:Phentolamine