Steroid-protein binding: from circulating blood to target cell nucleus.
The concept of protein binding of steroid hormones is traced from its origins through the period of confirmation and initial extension. Further considerations include cell surface recognition sites, subcellular sources of binding protein, and the new evidence that lysosomes participate in the translocation and intranuclear penetration of the hormone in steroid target cells. This short review thus aims to provide a link between current investigations and the ideas upon which they have been based.
D000818:Animals; D001665:Binding Sites; D001798:Blood Proteins / Q000378:metabolism; D002467:Cell Nucleus / Q000378:metabolism; D004967:Estrogens / Q000378:metabolism; D006801:Humans; D008247:Lysosomes / Q000378:metabolism; D011485:Protein Binding; D013256:Steroids / Q000378:metabolism*
D001798:Blood Proteins; D004967:Estrogens; D013256:Steroids