The effects of AMP on the potential of rat cerebral cortical neurones.
Intracellular recordings have shown that AMP, applied extracellularly, consistently produces a hyperpolarization in the absence of any pronounced alterations in membrane conductance and causes a reduction in spontaneously occurring and evoked postsynaptic potentials. Potential mechanisms of action of AMP are discussed, including the possibility that it may depress transmitter release from presynaptic nerve terminals.
D000249:Adenosine Monophosphate / Q000494:pharmacology*; D000818:Animals; D002540:Cerebral Cortex / Q000166:cytology*; D008564:Membrane Potentials / Q000187:drug effects; D009474:Neurons / Q000502:physiology*; D051381:Rats; D005680:gamma-Aminobutyric Acid / Q000494:pharmacology
D000249:Adenosine Monophosphate; D005680:gamma-Aminobutyric Acid