Does the pro-inflammatory factor in lymphocytes (LpIF) explain the role of these cells in acute inflammation?
Lymphocytes produce a pro-inflammatory factor, which modulates the development of acute inflammation. Injection of lymphocytes or products, obtained from either rats, dogs or rabbits, caused a restoration of inflammatory responses in leukopenic rats which are hyporeactive to various inflammatory stimuli. In vitro incubation of viable lymphocytes with homologous and heterologous anti-lymphocyte sera abolished the ability of the cells to restore the inhibited inflammatory reactions.
D000818:Animals; D000918:Antibody Specificity; D002351:Carrageenan; D004285:Dogs; D006736:Horses / Q000276:immunology; D066298:In Vitro Techniques; D007249:Inflammation / Q000139:chemically induced / Q000503:physiopathology*; D008214:Lymphocytes / Q000276:immunology / Q000502:physiology*; D008297:Male; D011817:Rabbits / Q000276:immunology; D051381:Rats; D013997:Time Factors
D002351:Carrageenan