[Actions of carbocromen of toxic effects of digitalis (author's transl)].
Experiments an anaesthetized dogs, rabbits and guinea pigs show that with clinically relevant doses of 3-(2-diethyl-aminoethyl)-4-methyl-7-(carbethoxy-methoxy)-2-oxo-1,2-chromene-hydrochloride (carbocromen, Intensain¿) the LD100 of digoxin (+50%) and ouabain (+60%) considerably increase. The positive inotropic effect of digoxin is not influenced by carbocromen. The appearance of arrhythmias is significantly delayed, the coupling between atrial and ventricular activity continues for a longer time. Besides effects on myocardial metabolism a membrane effect of carbocromen could be responsible for the improvement of the therapeutic range of digoxin and ouabain.
D000818:Animals; D001145:Arrhythmias, Cardiac / Q000139:chemically induced; D001794:Blood Pressure / Q000187:drug effects; D002866:Chromonar / Q000494:pharmacology*; D003374:Coumarins / Q000494:pharmacology*; D004077:Digoxin / Q000633:toxicity*; D004285:Dogs; D004347:Drug Interactions; D005260:Female; D006168:Guinea Pigs; D006321:Heart / Q000187:drug effects*; D006339:Heart Rate / Q000187:drug effects; D008297:Male; D009200:Myocardial Contraction / Q000187:drug effects; D011817:Rabbits
D003374:Coumarins; D004077:Digoxin; D002866:Chromonar
Wirkungen von Carbocromen auf toxische Digitaliseffekte