title: Initial observations on the administration of thymus extract (TFX) in patients with alimentary tract neoplasms.
abstract: The administration of thymus extract (TFX) has been performed in 35 patients suffering from malignancies of the alimentary tract. TFX, being a calf thymuses extract prepared by Jelenia Góra Drug Producers "Polfa" was given in the dose of 0.5 mg in 3 or 7-day intervals during several months. The immunological condition of patients was checked by many tests: E-rosettes, DLT (direct lymphocytotoxicity test) determination of absolute number of peripheral blood lymphocytes and skin tests (RT-23, PHA and TFX). Our observations revealed that TFX is biologically active also in humans, increases cell-mediated immunity and may restore the immune capability of patients operated due to malignancies of the alimentary tract.
mesh_terms: D000328:Adult; D000368:Aged; D005770:Gastrointestinal Neoplasms / Q000188:drug therapy* / Q000276:immunology; D006801:Humans; D008875:Middle Aged; D013949:Thymus Extracts / Q000276:immunology / Q000627:therapeutic use*
chemical_list: D013949:Thymus Extracts