Effects of lithium on foot shock-induced aggressive behavior in rats.
The effects of lithium chloride (LiC1; 1, 2, 3 mEq/kg, i.p.) were studied on foot shock-induced aggressive behavior categorized as 'hyperreactivity' 'pre-attack' and actual 'fight' or 'attack' scores in rats. The attack score was significantly decreased at all doses between 2 to 48 hr post-drug intervals. LiCl also antagonized both amphetamine-induced facilitation and scopolamine-induced suppression of the shock-induced aggression; these effects suggest a probable role of lithium in normalizing induced disturbances of both central adrenergic and cholinergic mechanisms and may at least partly be responsible for its psychotherapeutic efficacy as a "mood normalizer".
D000374:Aggression / Q000187:drug effects*; D000818:Animals; D003913:Dextroamphetamine / Q000494:pharmacology; D004347:Drug Interactions; D004597:Electroshock; D006801:Humans; D008094:Lithium / Q000494:pharmacology*; D008297:Male; D009043:Motor Activity / Q000187:drug effects; D051381:Rats; D012601:Scopolamine / Q000494:pharmacology; D013997:Time Factors
D008094:Lithium; D012601:Scopolamine; D003913:Dextroamphetamine