Dose-response effects of prostaglandin F2alpha on the rabbit oviduct: reproductive endocrine influence and tachyphylaxis.
The dose-response effect of PGF2alpha on the perfused oviduct of estrous and ovariectomized rabbits was determined. The oviducts of ovariectomized rabbits were more sensitive to the contractile effects of PGF2alpha than those of estrous rabbits. This was demonstrated by a significant difference in the slope of the dose-response curves and in the magnitude of the maximum responses between the two groups. Blood pressure responses (depressor) to PGF2alpha were not affected by the reproductive hormonal status of the rabbits. The oviduct (estrous rabbits) developed tachyphylaxis to the effect of PGF2alpha. It was concluded that the response of the rabbit oviduct to PGF2alpha is dependent on the reproductive hormone status of the animal and that the oviduct becomes insensitive to the effects of PGF2alpha with repeated administration.
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D004971:Estrus / Q000187:drug effects; D005187:Fallopian Tubes / Q000187:drug effects*; D005260:Female; D007213:Indomethacin / Q000494:pharmacology; D010053:Ovary / Q000502:physiology; D011247:Pregnancy; D011460:Prostaglandins F / Q000008:administration & dosage / Q000494:pharmacology*; D011817:Rabbits; D013618:Tachyphylaxis
D011460:Prostaglandins F; D007213:Indomethacin