title: Comparative pharmacology of josamycin and erythromycin stearate.
abstract: Two macrolide antibiotics, josamycin and erythromycin stearate, were administered orally to healthy, adult male volunteers for a comparative study of their pharmacological properties. In comparable doses, josamycin and erythromycin produced similar plasma concentrations, with similar half-lives and elimination constants. An initial loading dose of 1.5 g of josamycin produced greater peak concentrations of antibiotic throughout a 10-day period with a regimen of every 6 h. In addition, josamycin tended to reach higher peak and trough concentrations after regimens of every 6 or 8 h were maintained for 2 days. Josamycin penetrated into saliva, sweat, and tears, and it was better tolerated in fasting subjects than was erythromycin stearate.
mesh_terms: D000328:Adult; D000900:Anti-Bacterial Agents / Q000378:metabolism*; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D004917:Erythromycin / Q000008:administration & dosage / Q000009:adverse effects / Q000031:analogs & derivatives* / Q000097:blood; D006207:Half-Life; D006801:Humans; D007700:Kinetics; D007933:Leucomycins / Q000008:administration & dosage / Q000009:adverse effects / Q000378:metabolism*; D008297:Male; D012463:Saliva / Q000378:metabolism; D013542:Sweat / Q000378:metabolism; D013666:Tears / Q000378:metabolism
chemical_list: D000900:Anti-Bacterial Agents; D007933:Leucomycins; D004917:Erythromycin