[Oxidative phosphorylation in the myocardium of patients with mitral valve stenosis during surgery].
In 135 patients with mitral stenosis of the III and IV stages oxidative phosphorylation in the mitochondria of the left cardiac auricle was studied by the polarographic method. A uniform lowering of the mitochondrial respiration at different metabolic states with IV stage of the affection and in patiens of a more advanced age (36-52 years) was demonstrable. In some instances the conjugation of oxidation and phosphorylation was on a decline too. A nitrous oxide anesthesia (by comparison with the ether-oxygen one) produced a substantial depression of the mitochondrial respiration, especially when alpha-ketoglutarate was used. The sensitivity to the inhibitory effect of nitrous oxide in the elderly was higher. Respiration with succinate as a substrate in the young (20-35 years) patients proved little sensitive to the suppressing action of this type of anesthesia.
D000328:Adult; D000367:Age Factors; D000769:Anesthesia, Inhalation; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D008931:Mitochondria, Muscle / Q000378:metabolism*; D008946:Mitral Valve Stenosis / Q000378:metabolism / Q000601:surgery*; D009206:Myocardium / Q000378:metabolism*; D009609:Nitrous Oxide / Q000494:pharmacology; D010085:Oxidative Phosphorylation
D009609:Nitrous Oxide
Okislitel'noe fosforilirovanie v miokarde bol'nykh mitral'nym stenozom vo vremia operatsii