title: [Adaptational behaviour of peripheral and central acoustic responses in guinea pigs under the influence of various fractions of an extract from Gingko biloba (author's transl)].
abstract: Experimental studies on 114 guinea pigs proved definitely the influence of an extract from Ginkgo biloba batch no. 02 on the acoustic system. Experiments with animals ensured that the adaptation of excitation of the organ of Corti is significantly influenced. This result is shown by registrations of the acoustic nerve potentials in the adapted and nonadapted state. The relation of excitation to adaptation is significantly changed. Under adaptation of excitation an influence on the metabolism of involution is probable. The slow evoked potentials of the acoustic cortex showed no additional influence on the central auditory pathways. With the Ginkgo biloba extract it is probably possible to diminish sound damages caused by white noise. Further experiments on animals are necessary to ensure the application of this pharmaceutical preparation for clinical use.
mesh_terms: D000161:Acoustic Stimulation; D000200:Action Potentials / Q000187:drug effects*; D000818:Animals; D001303:Auditory Cortex / Q000187:drug effects* / Q000502:physiology; D005071:Evoked Potentials / Q000187:drug effects; D005419:Flavonoids / Q000494:pharmacology*; D006168:Guinea Pigs; D014665:Vasodilator Agents / Q000494:pharmacology*; D000159:Vestibulocochlear Nerve / Q000187:drug effects* / Q000502:physiology
chemical_list: D005419:Flavonoids; D014665:Vasodilator Agents
vernacular_title: Adaptationsverhalten peripherer und zentraler akustischer Reizantworten des Meerschweinchens unter dem Einfluss verschiedener Fraktionen eines Extraktes aus Ginkgo biloba