Increase in sialic acids removable by neuraminidase during the shape change of platelets.
Human or rabbit platelets were activated by ADP or 5-hydroxytrypatamine and rapidly fixed with glutaraldehyde. The shape change associated with activation gave rise to an increase in sialic acids removable by neuraminidase. This increase, like the shape change, was prevented by adenosine or methysergide added before ADP or 5-hydroxytryptamine respectively. The results indicate the exposure of additional glycoprotein(s) on the platelet surface.
D000244:Adenosine Diphosphate; D000818:Animals; D001792:Blood Platelets / Q000166:cytology / Q000378:metabolism*; D002462:Cell Membrane / Q000032:analysis; D006801:Humans; D066298:In Vitro Techniques; D008784:Methysergide; D009439:Neuraminidase / Q000378:metabolism; D011817:Rabbits; D012701:Serotonin; D012794:Sialic Acids / Q000097:blood* / Q000378:metabolism
D012794:Sialic Acids; D012701:Serotonin; D000244:Adenosine Diphosphate; D009439:Neuraminidase; D008784:Methysergide