title: Stimulation of lower esophageal sphincter pressure (LESP) by cimetidine -- a double-blind study.
abstract: Using the rapid pull-through technique the effect of 400 mg cimetidine perorally on lower oesophageal sphincter pressure was studied in a controlled trial in 14 subjects. Cimetidine caused a significant rise of the integrated basal pressure. The response to 0.6 mug/kg pentagastrin was augmented by cimetidine whereas under atropine sulphate infusion this effect could not be demonstrated. Cimetidine may act on LESP by blocking inhibiting receptors.
mesh_terms: D001285:Atropine / Q000494:pharmacology; D004347:Drug Interactions; D004943:Esophagogastric Junction / Q000187:drug effects*; D006146:Guanidines / Q000494:pharmacology*; D006801:Humans; D007093:Imidazoles / Q000494:pharmacology*; D010418:Pentagastrin / Q000494:pharmacology; D010919:Placebos; D011312:Pressure
chemical_list: D006146:Guanidines; D007093:Imidazoles; D010919:Placebos; D001285:Atropine; D010418:Pentagastrin