The influence of some antidepressant drugs on cardiac function. IV. Influence of blood supply of the heart in situ.
In in situ experiments with cats, impiramine, nortriptyline and amitriptyline depressed arterial blood pressure, diminished coroncary flow and amplitude of the heart's contraction, and slowed cardiac action.
D000639:Amitriptyline / Q000494:pharmacology*; D000818:Animals; D002415:Cats; D003326:Coronary Circulation / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D005260:Female; D006321:Heart / Q000187:drug effects*; D006339:Heart Rate; D007099:Imipramine / Q000494:pharmacology*; D008297:Male; D009200:Myocardial Contraction / Q000187:drug effects; D009661:Nortriptyline / Q000494:pharmacology*
D000639:Amitriptyline; D009661:Nortriptyline; D007099:Imipramine