[Hyperoxaluriaas a complication of intestinal diseases (author's transl)].
Urinary oxalate excretion was measured in healthy persons and patients with Crohn's disease, colitis ulcerosa, sprue and other diseases accompanied with malabsorption, and patients with insufficiency of the exocrine pancreas gland. Further measurements were made in patients after resection of parts of the small intestine or the colon. We found a clear increase of urinary oxalate excretion in patients with resected parts of the small intestine, sprue or other malabsorption syndromes. In 4 patients with resected parts of small intestine or pancreas we even found urolithiasis. Urinary oxalate excretion correlated significantly with steatorrhoea and increased if larger parts of small intestine were resected. Increased resorption of oxalate from food causes increased urinary excretion. Details about the patho-mechanism of this increased excretion are not known yet; an important factor seems to be the reduced absorption of fat in the small intestine.
D000328:Adult; D002446:Celiac Disease / Q000652:urine; D003093:Colitis, Ulcerative / Q000652:urine; D003424:Crohn Disease / Q000652:urine; D005243:Feces / Q000032:analysis; D005260:Female; D006801:Humans; D007410:Intestinal Diseases / Q000150:complications / Q000652:urine*; D007420:Intestine, Large / Q000601:surgery; D007421:Intestine, Small / Q000601:surgery; D008055:Lipids / Q000032:analysis; D008286:Malabsorption Syndromes / Q000652:urine; D008297:Male; D008875:Middle Aged; D010070:Oxalates / Q000652:urine*; D010182:Pancreatic Diseases / Q000652:urine; D014545:Urinary Calculi / Q000209:etiology / Q000517:prevention & control
D008055:Lipids; D010070:Oxalates
Hyperoxalurie als Komplikation bei Darmerkrankungen