Cholinesterase reactivators - contribution to the study of their metabolic effects.
Cholinesterase reactivators - trimedoxim, methoxim and obidoxim - injected in the dose of 20 mg/kg s.c., increase muscle glycogen concentration in normal, but not in adrenalectomized rats. This effect may be in connection with simoultaneously found rise of serum corticosteron level. Trimedoxim decreases adrenaline, methoxim and obidoxim noradrenaline concentration in adrenals.
D000311:Adrenal Glands / Q000187:drug effects / Q000502:physiology*; D000818:Animals; D002395:Catecholamines / Q000378:metabolism; D002801:Cholinesterase Reactivators / Q000494:pharmacology*; D003345:Corticosterone / Q000097:blood; D006003:Glycogen / Q000378:metabolism*; D008099:Liver / Q000187:drug effects / Q000201:enzymology; D009132:Muscles / Q000187:drug effects* / Q000378:metabolism; D051381:Rats
D002395:Catecholamines; D002801:Cholinesterase Reactivators; D006003:Glycogen; D003345:Corticosterone