Biochemical effect of ozone exposure in rats exposed to cigarette smoke.
Rats were exposed to three cigarettes per day for 35 days, under realistic conditions. Pulmonary glucose-6-phosphate dehydrogenase (G-6-PD) activity in the exposed animals increased 27% over control values (P less than .05). Subsequent exposure to acute, high-dose ozone (3 ppm for 4 hr) decreased the augmented G-6-PD activities to near normal levels, whereas ozone exposures in animals not exposed to cigarette smoke caused mild decreases in pulmonary G-6-PD activities. The importance of these findings with respect to the susceptibility of the smoker to oxidant exposures is unknown.
D000818:Animals; D004781:Environmental Exposure; D005954:Glucosephosphate Dehydrogenase / Q000378:metabolism*; D008168:Lung / Q000201:enzymology*; D008954:Models, Biological; D010126:Ozone / Q000494:pharmacology*; D051381:Rats; D012907:Smoking; D013997:Time Factors
D010126:Ozone; D005954:Glucosephosphate Dehydrogenase