[Results of repeated IgE titre determinations for the early diagnosis of tumour recurrence in the otolaryngological area (author's transl)].
Repeated serum IgE determinations in 292 tumour patients, in parallel with clinical check-ups, show the great diagnostic significance of the serum IgE level. The IgE titre variations give an insight into the tumour-host relationship and, in particular, into the current state of activity of the tumour patients who were found to be tumour-free after specific therapy have constant serum IgE values on repeated examination. The serum IgE level declines significantly during radiotherapy and after operative therapy. Tumour recurrence or metastases cause a sharp increase in the serum IgE level already before clinical manifestations can be ascertained. Hence, this method contributes through continued immunological checks towards an early diagnosis of tumour activity.
D000912:Antibodies, Neoplasm / Q000032:analysis; D000917:Antibody Formation; D004428:Ear Neoplasms / Q000276:immunology*; D006801:Humans; D007073:Immunoglobulin E / Q000302:isolation & purification*; D007822:Laryngeal Neoplasms / Q000276:immunology*; D009669:Nose Neoplasms / Q000276:immunology*; D010610:Pharyngeal Neoplasms / Q000276:immunology*; D011863:Radioimmunoassay; D013997:Time Factors
D000912:Antibodies, Neoplasm; D007073:Immunoglobulin E
Ergebnisse laufender IgE-Titerbestimmungen zur Frühdiagnostik bei Tumorerkrankungen im HNO-Bereich