Blockade of apomorphine-induced aggression by morphine or neuroleptics: differential alteration by antimuscarinics and naloxone.
Both morphine and the neuroleptics, haloperidol and oxyperomide, dose-dependently reduce the aggression in rats produced by 20 mg/kg of apomorphine, a dopamine receptor stimulant. The narcotics antagonist, naloxone, prevents this effect of morphine but not the effect of neuroleptics. Dexetimide, a centrally acting antimuscarnic drug, antagonizes the reduction in aggression produced by the neuroleptics, but does not affect morphine's action. The cholinergic agonist, pilocarpine, enhances this action of oxyperomide. These results suggest that a cholinergic component contributes to the anti-agression action of neuroleptics and demonstrates a difference in the mechanism of action between neuroleptics and morphine.
D000374:Aggression / Q000187:drug effects*; D000818:Animals; D001058:Apomorphine / Q000037:antagonists & inhibitors*; D004347:Drug Interactions; D006801:Humans; D008297:Male; D009020:Morphine / Q000494:pharmacology*; D009270:Naloxone / Q000494:pharmacology*; D010276:Parasympatholytics / Q000494:pharmacology*; D010862:Pilocarpine / Q000494:pharmacology; D051381:Rats; D013997:Time Factors; D014149:Tranquilizing Agents / Q000494:pharmacology*
D010276:Parasympatholytics; D014149:Tranquilizing Agents; D010862:Pilocarpine; D009270:Naloxone; D009020:Morphine; D001058:Apomorphine