Analysis of the cross-reactive immune suppression induced by the random copolymers L-glutamic acid50-L-tyrosine50 (GT), L-glutamic acid60-L-alanine40 and L-glutamic acid60-L-alanine30-L-tyrosine10 (GAT).
Cross-reactivity in the induction of immune suppression by the structurally related polymers of L-glutamic acid, L-alanine, and/or L-tyrosine (GAT, GA, GT) was studied. SJL (H-2S) and DBA/1 (H-2q) mice are nonresponders to GAT and GT, whereas SJL, but not DBA/1 responds to GA. Both strains respond to these polymers when complexed to the immunogenic carrier methylated bovine serum albumin (MBSA). Preimmunization with GA suppresses GA-MBSA as well as GAT-MBSA and GT-MBSA plaque-forming cell (PFC) responses in DBA/1 mice. Likewise, GAT suppresses GAT-MBSA and GA (SJL) and GA-MBSA (DBA/1) PFC responses in both strains while being totally ineffective on GT-MBSA responses. GT preimmunization suppressed GA, GAT-MBSA, and GT-MBSA PFC responses in SJL but not DBA/1 responses. This study demonstrates that cross-reactive immune suppression does not follow predictable patterns based upon cross-reactivity of specific antibodies and that cross-suppression is not reciprocal.
D000409:Alanine / Q000276:immunology*; D000818:Animals; D000917:Antibody Formation; D003429:Cross Reactions; D005260:Female; D005971:Glutamates / Q000276:immunology*; D007114:Immunization; D007074:Immunoglobulin G; D007165:Immunosuppression Therapy; D008297:Male; D051379:Mice; D008811:Mice, Inbred DBA; D008815:Mice, Inbred Strains; D011108:Polymers / Q000276:immunology*; D012710:Serum Albumin, Bovine / Q000276:immunology; D014443:Tyrosine / Q000276:immunology*
D005971:Glutamates; D007074:Immunoglobulin G; D011108:Polymers; D012710:Serum Albumin, Bovine; D014443:Tyrosine; D000409:Alanine