Synthesis and pharmacological properties of some new 1,1-diarylacetic acid derivatives.
A series of 13 new 1,1-diphenylacetic acid derivatives was synthesized via common transformations of 2-phenyl-2-(p-nitrophenyl) propio- and butyronitriles. The compounds were submitted to pharmacological screening. 2-Phenyl-2-(p-aminophenyl)propionamide (VIII) showed high anticonvulsant activity.
D000927:Anticonvulsants / Q000138:chemical synthesis*; D055598:Chemical Phenomena; D002621:Chemistry; D004158:Diphenylacetic Acids / Q000138:chemical synthesis*
D000927:Anticonvulsants; D004158:Diphenylacetic Acids