[Effect of hydrocortisone and actinomycin D at different time of the day on incorporation of labeled precursor into the nuclear proteins of intact rat liver].
Variations in the incorporation of labelled precursor into nuclear rat liver proteins during a day in normal conditions and in the presence of hydrocortisone and actinomycin D are studied. Synthesis of nuclear proteins is found to have a fluctuating character. Hydrocortisone and actinomycin D, injected at different day time, induce changes in the character of nuclear proteins synthesis , which are more pronounced for histones. The effect of the hormone and the antibiotic is tightly bound with the functional state of liver cells at given moment.
D000818:Animals; D002467:Cell Nucleus / Q000378:metabolism; D003609:Dactinomycin / Q000494:pharmacology*; D006657:Histones / Q000096:biosynthesis; D006854:Hydrocortisone / Q000494:pharmacology*; D008099:Liver / Q000378:metabolism / Q000648:ultrastructure*; D008297:Male; D009698:Nucleoproteins / Q000096:biosynthesis*; D051381:Rats; D013997:Time Factors
D006657:Histones; D009698:Nucleoproteins; D003609:Dactinomycin; D006854:Hydrocortisone
Vliianie gidrokortizona i aktinomitsina D v raznoe vremia sutok na vkliuchenie mechenogo predshestvennika v iadernye belki intaktnoĭ pecheni krys