Effects of human chorionic gonadotropin preparations on amino acid uptake and incorporation into protein in vitro.
Human chorionic gonadotropin preparations were tested for their effect on protein metabolism by cultured fibroblasts. Commercial preparations of HCG strongly inhibit amino acid uptake and incorporation into protein by a variety of human adult and fetal fibroblast lines, whereas, highly purified HCG is without such an effect.
D000596:Amino Acids / Q000378:metabolism*; D001692:Biological Transport; D002478:Cells, Cultured; D006063:Chorionic Gonadotropin / Q000494:pharmacology*; D005333:Fetus; D005347:Fibroblasts / Q000187:drug effects / Q000378:metabolism; D006801:Humans; D008168:Lung / Q000187:drug effects / Q000378:metabolism; D014176:Protein Biosynthesis / Q000187:drug effects*; D012867:Skin / Q000187:drug effects / Q000378:metabolism
D000596:Amino Acids; D006063:Chorionic Gonadotropin