Collagen synthesis and deposition in cartilage during disrupted proteoglycan production.
A simple system was developed to investigate in vitro the possible relationship between collagen and proteoglycan synthesis in cartilage. When production of complete proteoglycan molecules was effectively inhibited with 4-methylumbelliferyl beta-D-xyloside collagen synthesis and distribution were virtually unaffected.
D000818:Animals; D002356:Cartilage / Q000187:drug effects / Q000378:metabolism*; D003094:Collagen / Q000096:biosynthesis*; D006025:Glycosaminoglycans / Q000032:analysis; D006027:Glycosides / Q000494:pharmacology*; D006923:Hymecromone / Q000031:analogs & derivatives / Q000494:pharmacology*; D066298:In Vitro Techniques; D011509:Proteoglycans / Q000096:biosynthesis*; D013552:Swine; D014468:Umbelliferones / Q000494:pharmacology*
D006025:Glycosaminoglycans; D006027:Glycosides; D011509:Proteoglycans; D014468:Umbelliferones; D006923:Hymecromone; D003094:Collagen