[Study of solubility rate of polysaccharide carriers for prolonlonging the effect of drugs in chronic experiment].
To study the process of dissolving polysaccharide carriers in the body used to prolong the action of drugs microspheric preparations of aldehyde-sephadexes of different degrees of oxidation containing I131-labelled covalently bound human serum albumin were synthesized. A radioisotope study of the rate of solution of the mentioned preparations injected by way of catheterization into the myocardial capillary network was conducted. The obtained carriers were shown to be harmless capable of prolonged retention of the bound protein at the site of injection, the rate of their solution in vivo and in vitro being nearly equal.
D000447:Aldehydes / Q000378:metabolism*; D000818:Animals; D001711:Biotransformation; D003331:Coronary Vessels / Q000378:metabolism; D004285:Dogs; D014677:Pharmaceutical Vehicles; D011134:Polysaccharides / Q000378:metabolism*; D011485:Protein Binding; D012711:Serum Albumin, Radio-Iodinated; D012995:Solubility
D000447:Aldehydes; D014677:Pharmaceutical Vehicles; D011134:Polysaccharides; D012711:Serum Albumin, Radio-Iodinated
Izuchenie skorosti rastvoreniia polisakharidnykh nositeleĭ dlia prolongirovaniia deĭstviia lekarstvennykh preparatov v khronicheskom eksperimente