Thymosin induced changes in the cell cycle of lymphocytes from aging neonatally thymectomized rats.
The potential role of the endocrine thymus on the cell cycle of lymphocytes from aging neonatally thymectomized rats (LAT cells) was investigated using thymosin fraction 5. Thymosin rendered LAT cells similar to normal lymphocytes with regard to reconstituting the median S+G2 phase of the LAT cell. This is the first study to demonstrate an effect of thymosin on the cell cycle of lymphocyte populations.
D000375:Aging; D000818:Animals; D000831:Animals, Newborn; D002455:Cell Division / Q000187:drug effects*; D002478:Cells, Cultured; D005260:Female; D037102:Lectins; D008198:Lymph Nodes / Q000166:cytology; D008213:Lymphocyte Activation / Q000187:drug effects; D008214:Lymphocytes / Q000502:physiology*; D008727:Methotrexate; D051381:Rats; D013934:Thymectomy; D013947:Thymosin / Q000494:pharmacology*; D013951:Thymus Hormones / Q000494:pharmacology*
D037102:Lectins; D013951:Thymus Hormones; D013947:Thymosin; D008727:Methotrexate