[Experimental studies on diffusion of gentamicin into body fluids (author's transl)].
For the purpose of measuring concentrations of gentamicin (GM) into body fluids (pancreatic juice, abdominal cavity, and bile) after intramuscular injection, the authors conducted experiments using adult mongrel dogs with following results. 1) The highest concentration in pancreatic juice was observed 1 approximately 1.5 hours after single intramuscular administration of 4 mg/kg. The highest concentration was 51.3% of that in blood. 2) The highest concentration in bile was observed 30 minutes approximately 1 hour after single intramuscular administration of GM. The concentration was about 50% of that in blood. 3) The diffusion of GM into the abdominal cavity was good after single intramuscular administration. 4) The rate of urinary excretion was high as is generally known.
D000293:Adolescent; D000328:Adult; D000818:Animals; D001202:Ascitic Fluid / Q000032:analysis; D001646:Bile / Q000032:analysis; D001826:Body Fluids / Q000032:analysis*; D002648:Child; D004285:Dogs; D005260:Female; D005839:Gentamicins / Q000009:adverse effects / Q000378:metabolism* / Q000627:therapeutic use; D006801:Humans; D007273:Injections, Intramuscular; D008297:Male; D008875:Middle Aged; D010189:Pancreatic Juice / Q000032:analysis; D013530:Surgical Wound Infection / Q000188:drug therapy; D014552:Urinary Tract Infections / Q000188:drug therapy
D005839:Gentamicins