title: [The reactions of embryonic tissues and cells to xantinol-nicotinate in the culture (author's transl)].
abstract: The influence of xantinol-nicotinate (Complamin) or with its chemical designation 7-[2-hydroxy-3-(N-2-hydroxy-ethyl-N-methylamino) propyl]-1,3-dimethylxanthinepyridine-3-carboxylate and its formula: C19H26N6O6, on 2500 tissue cultures of embrynic epithelium, bone and connective tissues from the domestic chicken was examined. It was found that xantine-nicotinate at high concentrations strongly inhibits cell proliferation. It seems possible that this substance is insolubly bound to the nucleic acids. With the diminution of the concentration to values corresponding those in the human organism, the stimulation effects on mitosis and cell proliferation were striking, in bone and connective tissues stronger than in the epithelial tissues. In tissue culture there appeared eventually remarkable effects with very high doses not applied in human medicine.
mesh_terms: D000818:Animals; D001842:Bone and Bones / Q000187:drug effects / Q000196:embryology*; D002455:Cell Division / Q000187:drug effects; D002642:Chick Embryo; D003238:Connective Tissue / Q000187:drug effects / Q000196:embryology*; D003331:Coronary Vessels / Q000187:drug effects / Q000196:embryology; D046508:Culture Techniques; D004848:Epithelium / Q000187:drug effects / Q000196:embryology*; D006321:Heart / Q000196:embryology; D008099:Liver / Q000196:embryology; D008168:Lung / Q000187:drug effects / Q000196:embryology; D008938:Mitosis / Q000187:drug effects; D012867:Skin / Q000196:embryology; D013131:Spine / Q000196:embryology; D013806:Theophylline / Q000031:analogs & derivatives*; D014059:Tongue / Q000196:embryology; D014971:Xanthinol Niacinate / Q000494:pharmacology*
chemical_list: D014971:Xanthinol Niacinate; D013806:Theophylline
vernacular_title: Die Reaktionen von embryonalen Geweben und Zellen auf Xantinol-nicotinat in Kultur