Hypothermia dn alphamethyldopa treatment.
The hypotensive drug alphamethyldopa, an inhibitor of serotonin synthesis, caused significant hypothermia ranging from 33.4 to 34.8 degrees C (t=3.09 at P less than 0.05) in four out of nine hypertensive patients, with evidence of cerebral atherosclerosis. The anti-serotonin effect of alphamethyldopa correlated with statistically significant (t=6.8 at P less than 0.001) fall in the 24 hour urinary 5-hydroxyindoleacetic acid on the third day of the therapy. The possible mode of hypothermic side effect is discussed.
D000293:Adolescent; D000328:Adult; D000368:Aged; D006801:Humans; D006897:Hydroxyindoleacetic Acid / Q000652:urine; D006973:Hypertension / Q000150:complications / Q000652:urine; D007035:Hypothermia / Q000139:chemically induced*; D002537:Intracranial Arteriosclerosis / Q000150:complications; D008297:Male; D008750:Methyldopa / Q000009:adverse effects*; D008875:Middle Aged
D006897:Hydroxyindoleacetic Acid; D008750:Methyldopa