title: Some behavioural changes induced by amantadine (adamantine).
abstract: In experiments carried out in mice, it was shown that amantadine (adamantine) (50, 75, 100 and 200 mg/kg i.p.) reduced the exploratory activity. This phenomenon was due not to reduction of the locomotion and of the muscular force. Amantadine in large doses had a slight convulsant action; at the same dose (100 mg/kg i.p.) it greatly potentiated the convulsant effects of pentetrazol. On Haffner's test amantadine had no analgesic activity.
mesh_terms: D000547:Amantadine / Q000494:pharmacology*; D000661:Amphetamine / Q000494:pharmacology; D000698:Analgesia; D000818:Animals; D005106:Exploratory Behavior / Q000187:drug effects*; D005260:Female; D008297:Male; D051379:Mice; D009132:Muscles / Q000502:physiology; D051381:Rats; D013777:Tetrazoles / Q000494:pharmacology
chemical_list: D013777:Tetrazoles; D000547:Amantadine; D000661:Amphetamine