title: [Synthesis and biological activity of 1,2,3-triazol-1,8-naphthyridines].
abstract: The reaction of 2-methyl-5-azido-1,8-naphthyridine with active methylene compounds was investigated. Several naphthyridines which possess the 1,2,3-triazole ring as a substituent were obtained. Among these compounds (IV o) showed an analgesic activity twice that of phenylbutazone.
mesh_terms: D000700:Analgesics / Q000138:chemical synthesis* / Q000494:pharmacology; D000818:Animals; D001419:Bacteria / Q000187:drug effects; D005658:Fungi / Q000187:drug effects; D008297:Male; D051379:Mice; D009287:Naphthyridines / Q000138:chemical synthesis* / Q000494:pharmacology; D051381:Rats; D012110:Reserpine / Q000037:antagonists & inhibitors; D014230:Triazoles / Q000138:chemical synthesis* / Q000494:pharmacology
chemical_list: D000700:Analgesics; D009287:Naphthyridines; D014230:Triazoles; D012110:Reserpine
vernacular_title: Sintesi e attivita biologica di derivati 1,2,3-triazol-1,8-naftiridinici