Metabolism of daunorubicin by a barbiturate-sensitive aldehyde reductase from rat liver.
A barbiturate-sensitive aldehyde reductase was purified to homogeneity from rat liver and shown to metabolize the cancer-chemotherapeutic antibiotic daunorubicin. The aldehyde reductase may have important roles in the metabolism of exogeneous drugs as well as the aldehyde derivatives of the biogenic amines.
D000445:Aldehyde Oxidoreductases / Q000037:antagonists & inhibitors / Q000378:metabolism*; D000818:Animals; D001462:Barbital / Q000494:pharmacology; D003630:Daunorubicin / Q000378:metabolism*; D008099:Liver / Q000201:enzymology*; D010672:Phenytoin / Q000494:pharmacology; D051381:Rats
D001462:Barbital; D010672:Phenytoin; D000445:Aldehyde Oxidoreductases; D003630:Daunorubicin