Effect of dietary fats on pentobarbitone-induced sleeping times and hepatic microsomal cytochrome P-450 in rats.
Female Wistar-derived rats were fed diets containing either sunflowerseed oil or tallow for 4 weeks. Rats fed the sunflowerseed oil diet had longer pentobarbitone-induced sleeping times and lower concentrations of hepatic microsomal cytochrome P-450 than rats fed the tallow diet. The addition of pentobarbitone to the drinking water of rats caused approximately 2-fold increases in the concentrations of hepatic microsomal cytochrome P-450 but did not alter the relative effect of the diets.
D000818:Animals; D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism*; D004041:Dietary Fats; D005227:Fatty Acids / Q000494:pharmacology; D005260:Female; D008099:Liver / Q000473:pathology; D008862:Microsomes, Liver / Q000187:drug effects / Q000201:enzymology*; D009929:Organ Size; D010424:Pentobarbital; D011506:Proteins / Q000378:metabolism; D051381:Rats; D012890:Sleep / Q000187:drug effects
D004041:Dietary Fats; D005227:Fatty Acids; D011506:Proteins; D003577:Cytochrome P-450 Enzyme System; D010424:Pentobarbital