Anticholinergic and cardiodepressive effects of levomepromazine and two of its metabolites on isolated rat atria.
The effects of monodesmethyl levomepromazine on effective refractory period (ERP) threshold for electrical stimulation and contractile force on isolated rat atria were compared to the effects of levomepromazine and levomepromazine sulfoxide. All agents caused an apparently dose-dependent increase in ERP, and antagonized acetylcholine-induced reductions in ERP. Levomepromazine and monodesmethyl levomepromazine decreased excitability and contractile force to a similar extent.
D000109:Acetylcholine / Q000037:antagonists & inhibitors; D000818:Animals; D003864:Depression, Chemical; D004558:Electric Stimulation; D005260:Female; D006321:Heart / Q000187:drug effects* / Q000502:physiology; D066298:In Vitro Techniques; D008728:Methotrimeprazine / Q000031:analogs & derivatives* / Q000494:pharmacology*; D009200:Myocardial Contraction / Q000187:drug effects; D010276:Parasympatholytics; D051381:Rats; D012032:Refractory Period, Electrophysiological / Q000187:drug effects
D010276:Parasympatholytics; D008728:Methotrimeprazine; D000109:Acetylcholine