title: [Effects of aromatic bisamidines on blood coagulation and fibrinolysis].
abstract: The effect of the aromatic diamidine derivative 2,6-bis (4-amidinobenzyl)-cyclohexanon-(1) on blood coagulation and fibrinolysis in vitro and in vivo was compared with that of the benzamidine derivative 4-amidinophenyl pyruvic acid and the aromatic diamidine derivative 4,4'-diamidinophenoxypentane. 2,6-Bis(4-amidinobenzyl)-cyclohexanon-(1) was found to be a strong inhibitor of the clotting enzyme thrombin. Because of the toxic side effects and pharmacokinetic properties of both diamidine derivatives their in vivo use as anticoagulants is limited.
mesh_terms: D000578:Amidines / Q000494:pharmacology*; D000818:Animals; D001777:Blood Coagulation / Q000187:drug effects*; D002417:Cattle; D005342:Fibrinolysis / Q000187:drug effects*; D006801:Humans; D006868:Hydrolysis; D010667:Phenylpyruvic Acids / Q000494:pharmacology; D010974:Platelet Aggregation / Q000187:drug effects
chemical_list: D000578:Amidines; D010667:Phenylpyruvic Acids
vernacular_title: Zur Wirkung von aromatischen Bisamidinen auf Blutgerinnungs- und Fibrinolysevorgänge