title: [Brain development: genetic and exogenous factors].
abstract: Growth disorders and differentiation of cerebral structures may be caused by mutations of exogenous noxae. The period of most active brain development is between the tenth week of pregnancy and the tenth year of life. In this period the brain is particularly sensitive to exogenous noxae. Basic research has revealed mechanisms that are responsible for normal development, and at the same time has led to the discovery of factors which may be associated with disturbance of these regulatory processess. Disorders of cerebral development may underlie minimal organic brain damage, though there is no proof of this as yet. Closer cooperation between basic and clinical research will be necessary to provide greater insight into the mechanisms of cerebral development. The knowledge thus obtained is one of the preconditions for the prevention, diagnosis and treatment of infantile minimal organic brain damage.
mesh_terms: D000818:Animals; D001289:Attention Deficit Disorder with Hyperactivity / Q000209:etiology / Q000235:genetics; D001921:Brain / Q000254:growth & development*; D002454:Cell Differentiation; D002455:Cell Division; D004410:Dyslexia / Q000235:genetics; D005260:Female; D005315:Fetal Diseases / Q000150:complications; D005799:Genes, Dominant; D006801:Humans; D000860:Hypoxia / Q000150:complications; D007231:Infant, Newborn; D011247:Pregnancy; D051381:Rats
vernacular_title: Hirnentwicklung: genetische und exogene faktoren