[Inhibition of cholinesterase activity in the brain of rats by phosphoorganic inhibitors with different degrees of hydrophobia].
The activity of cholinesterase in different areas of the rat brain was studied as affected by two organophosphophorous inhibitors of the enzyme from the group of O-alkyl-S-hexylthiophosphonates, GA-89 and GA-95. Hydrophobity of GA-95 is two order higher than that of GA-89. Under the effect of GA-89 inhibition of cholinesterase in the brain is considerably higher than in blood, under the effect of GA-95 an inverse relation is observed. When both compounds are administered, the activity of cholinesterase in the cerebral cortex is most inhibited.
D000818:Animals; D001921:Brain / Q000201:enzymology*; D002531:Cerebellum / Q000201:enzymology; D002540:Cerebral Cortex / Q000201:enzymology; D002800:Cholinesterase Inhibitors / Q000494:pharmacology*; D002802:Cholinesterases / Q000378:metabolism*; D003342:Corpus Striatum / Q000201:enzymology; D004027:Diencephalon / Q000201:enzymology; D008297:Male; D008526:Medulla Oblongata / Q000201:enzymology; D008636:Mesencephalon / Q000201:enzymology; D009946:Organothiophosphorus Compounds / Q000494:pharmacology*; D051381:Rats
D002800:Cholinesterase Inhibitors; D009946:Organothiophosphorus Compounds; D002802:Cholinesterases
Ugnetenie kholinésterazoĭ aktivnosti v mozga krys fosfororganicheskimi ingibitorami s razlichnoĭ stepen'iu gidrofobnosti