Simultaneous quantification of procainamide and N-acetylprocainamide with high-performance liquid chromatography.
A rapid, precise and specific method for the simultaneous determination of procainamide and N-acetylprocainamide (NAPA) in plasma using high-performance liquid chromatography is described. N-Formylprocainamide was utilized as internal standard. The coefficients of variation of the method for both procainamide and NAPA were 3.6% in the range of plasma levels to be expected clinically. The method is especially useful for rapid determination of acetylator phenotype in patients requiring procainamide for control of arrhythmias.
D001145:Arrhythmias, Cardiac / Q000188:drug therapy; D002851:Chromatography, High Pressure Liquid; D006801:Humans; D010641:Phenotype; D011342:Procainamide / Q000031:analogs & derivatives* / Q000097:blood* / Q000627:therapeutic use; D013997:Time Factors
D011342:Procainamide