Induction of glycosuria and hyperglycemia by topical corticosteroid therapy.
A patient with psoriasis is described who had an abnormal response to the glucose tolerance test without other evidence of diabetes and then developed postprandial hyperglycemia and glycosuria during a period of topical administration of a corticosteroid cream, halcinonide cream 0.1%, under occlusion. A second patient with a similar glucose tolerance test result showed postprandial hyperglycemia when treated similarly with betamethasone valerate cream 0.1%. Two additional patients with midly abnormal responses to glucose tolerance tests showed no evidence of altered glucose metabolism when treated with halcinonide cream in a similar manner.
D000287:Administration, Topical; D000305:Adrenal Cortex Hormones / Q000008:administration & dosage / Q000009:adverse effects*; D000328:Adult; D001624:Betamethasone Valerate / Q000009:adverse effects; D005260:Female; D005951:Glucose Tolerance Test; D006029:Glycosuria / Q000139:chemically induced*; D006801:Humans; D006943:Hyperglycemia / Q000139:chemically induced*; D008297:Male; D008875:Middle Aged; D011236:Prediabetic State / Q000175:diagnosis; D011565:Psoriasis / Q000188:drug therapy
D000305:Adrenal Cortex Hormones; D001624:Betamethasone Valerate