6-Sulfanilamidoindazole arthritis of the rat: complement activity and sulfhydryl group concentration of the serum in three different phases of inflammation.
In 6-sulfanilamidoindazole (6-SAI) arthritis the total haemolytic complement activity of the serum was significantly increased by 69% in developing arthritis at day 4, and by 42% in fully developed arthritis at day 8. In declining arthritis at day 12, 5 days after the last administration of the prophlogistic agent 6-SAI, no difference of the serum complement activity between arthritic rats and non-arthritic controls could be determined. The serum SH group concentration was significantly decreased by 31% at day 4 and by 54% at day 8, but it was nearly normalized at day 12. There was no close correlation between increase of paw diameter and serum complement activity in 6-SAI-arthritic rats. It is suggested that investigations on the role that complement components might play in 6-SAI arthritis could be interest.
D000818:Animals; D001169:Arthritis, Experimental; D003165:Complement System Proteins / Q000032:analysis*; D007191:Indazoles / Q000494:pharmacology*; D008297:Male; D010489:Periarthritis / Q000097:blood / Q000139:chemically induced / Q000276:immunology*; D011720:Pyrazoles / Q000494:pharmacology*; D051381:Rats; D013424:Sulfanilamides / Q000494:pharmacology*; D013438:Sulfhydryl Compounds / Q000097:blood*
D007191:Indazoles; D011720:Pyrazoles; D013424:Sulfanilamides; D013438:Sulfhydryl Compounds; C009347:6-sulfanilamidoindazole; D003165:Complement System Proteins