Use of clindamycin and gentamicin in pediatric colonic surgery.
The combination of clindamycin and gentamicin was used to treat 25 pediatric surgical patients. In 9 of the 11 patients with perforated appendicitis, B. fragilis was isolated from the peritoneal cavity. There was a rapid clinical response to treatment in all cases. No side effects were observed. Clindamycin and gentamicin seem to be the antibiotics of choice for such infections.
D001064:Appendicitis / Q000601:surgery; D001424:Bacterial Infections / Q000517:prevention & control*; D001441:Bacteroides fragilis / Q000302:isolation & purification; D002648:Child; D002675:Child, Preschool; D002981:Clindamycin / Q000627:therapeutic use*; D003106:Colon / Q000601:surgery*; D004338:Drug Combinations; D005260:Female; D005839:Gentamicins / Q000627:therapeutic use*; D006801:Humans; D007223:Infant; D008297:Male; D011183:Postoperative Complications / Q000517:prevention & control*
D004338:Drug Combinations; D005839:Gentamicins; D002981:Clindamycin