[Lipid mobilization in obesity without carbohydrate intolerance. 2. Caffeine-stimulated lipolysis].
The lipolysis induced by i.v. injection of caffeine (3 mg/kg body weight) has been investigated in 11 normal subjects and 18 obese patients with normal 50 g oral glucose tolerance test and normal thyroid-function. The pattern of blood-glucose and immunoreactive insulin (IRI) secretion were not influenced by caffeine in both groups. Both in the controls and obese group a significant response of FFA and glycerole were noted. In the obese group the caffeine-induced lipolysis was slightly higher as compared with controls. There are no differences in FFA-response between obese group and controls. The observations suggest that an impaired lipolysis is not a pathogenetic factor for development of obesity.
D000328:Adult; D001786:Blood Glucose / Q000032:analysis; D002110:Caffeine / Q000494:pharmacology*; D005230:Fatty Acids, Nonesterified / Q000097:blood; D005260:Female; D005990:Glycerol / Q000097:blood; D006801:Humans; D007328:Insulin / Q000097:blood; D008053:Lipid Mobilization / Q000187:drug effects*; D008297:Male; D009765:Obesity / Q000378:metabolism*
D001786:Blood Glucose; D005230:Fatty Acids, Nonesterified; D007328:Insulin; D002110:Caffeine; D005990:Glycerol
Untersuchungen zur Lipidmobilisation bei Adipositas ohne Kohlenhydratintoleranz. 2. Mitteilung: Zur Koffeinstimulierten Lipolyse