Carbenicillin half-life in children with early diabetes mellitus.
It has been shown earlier by the authors that the glomerular filtration rate (GFR) and the penicillin clearance are increased in short-term childhood diabetes. Recently, GFR and carbenicillin half-life (T/2) were determined in insulin-treated children with a diabetes duration of 1-5 years, and in a healthy control group. An inverse relationship, between carbenicillin T/2 and GFR was found in both groups. The GFR was significantly higher, and the carbeniciliin T/2 significantly lower in diabetic children than in healthy controls. There was no correlation to blood sugar levels. It is suggested that the accelerated elimination of penicillin and carbenicillin in early diabetes necessitates higher dosages of these drugs for an adequate therapeutic effect.
D000293:Adolescent; D002228:Carbenicillin / Q000097:blood*; D002648:Child; D003922:Diabetes Mellitus, Type 1 / Q000097:blood* / Q000503:physiopathology; D005260:Female; D005919:Glomerular Filtration Rate; D006207:Half-Life; D006801:Humans; D008297:Male
D002228:Carbenicillin