[The genetics of Gilbert syndrome].
Investigation of 19 unrelated patients with Gilbert's syndrome and family studies in 21 first degree relatives of 7 of these patients are in agreement with an autosomal-dominant mode of inheritance with incomplete penetrance. The calculated penetrance in our study is 57%. HLA typing (locus A, B, C) showed a slight, insignificant increase in antigens A11 and BW35. Furthermore, this syndrome did not segregate in parallel with certain haplotypes within families.
D001663:Bilirubin / Q000097:blood; D005799:Genes, Dominant; D005878:Gilbert Disease / Q000235:genetics*; D006680:HLA Antigens / Q000032:analysis; D006650:Histocompatibility Testing; D006933:Hyperbilirubinemia, Hereditary / Q000235:genetics*
D006680:HLA Antigens; D001663:Bilirubin
Untersuchungen zur Genetik des Gilbert-Syndroms