F-461, 3-diethylamino-2,2-dimethylpropyl 5-(p-nitrophenyl)-2-furoate hydrochloride, a new non-anticholinergic spasmolytic and gastric acid inhibitor.
Compound F-461, 3-diethylamino-2,2-dimethylpropyl 5-(p-nitrophenyl)-2-furoate hydrochloride, was evaluated pharmacologically and was found to exert non-anticholinergic smooth muscle spasmolytic activity along the gastrointestinal tract of animals. F-461 was additionally discovered to inhibit gastric acid secretion and to prevent cold + restraint stress-induced ulcers. Local anesthesia, both surface and infiltration, was also elicited by F-461. The pharmacologic properties of F-461, as revealed in this study, are indicative of potential usefulness of this drug in the therapy of spastic colon and/or peptic ulcers.
D000779:Anesthetics, Local / Q000494:pharmacology; D000818:Animals; D002606:Charcoal / Q000378:metabolism; D003106:Colon / Q000187:drug effects; D003864:Depression, Chemical; D004285:Dogs; D004347:Drug Interactions; D004386:Duodenum / Q000187:drug effects; D005663:Furans / Q000494:pharmacology*; D005750:Gastric Juice / Q000378:metabolism; D005765:Gastrointestinal Agents / Q000494:pharmacology*; D007082:Ileum / Q000187:drug effects; D066298:In Vitro Techniques; D008297:Male; D051379:Mice; D009119:Muscle Contraction / Q000187:drug effects; D009538:Nicotine / Q000494:pharmacology; D010276:Parasympatholytics / Q000494:pharmacology*; D011817:Rabbits; D013270:Stomach / Q000187:drug effects; D013666:Tears / Q000187:drug effects; D014456:Ulcer / Q000209:etiology
D000779:Anesthetics, Local; D005663:Furans; D005765:Gastrointestinal Agents; D010276:Parasympatholytics; D002606:Charcoal; C013355:F 461; D009538:Nicotine