Studies on the physiology and biochemistry of female genital tract of albino rats: response of uterus, cervix and vagina to two different dose ratios of estrogen and progesterone.
Effect of two different dose ratios of estrogen (E) and progesterone (P) (1:1000; 1:10,000) on the morphological and biochemical response of the uterus, cervix and the vagina of ovariectomized estrogen pretreated rats was studied. It was observed that the dose ratio of E & P at 1:1000 did not produce any remarkable ponderal and histological changes from that seen under the influence of estrogen alone. Whereas, in the dose ratio of E & P at 1:10,000 progesterone appeared to inhibit the effect of estrogen. The biochemical response of the uterus, cervix and vagina, however, varied from each other in both the dose ratios.
D000818:Animals; D002584:Cervix Uteri / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D004958:Estradiol / Q000008:administration & dosage* / Q000494:pharmacology; D005260:Female; D011374:Progesterone / Q000008:administration & dosage* / Q000494:pharmacology; D051381:Rats; D014599:Uterus / Q000187:drug effects*; D014621:Vagina / Q000187:drug effects*
D011374:Progesterone; D004958:Estradiol