Increased aggression in rats after withdrawal of long term used oxazepam.
The withdrawal of oxazepam (5 mg/kg i.p.) applied for 1 year in rats, increased shock-induced aggression of animals. This phenomenon is interpreted as a sign of abstinence and suggests that long-term treatment causes dependence to oxazepam in rats.
D000374:Aggression / Q000187:drug effects*; D000818:Animals; D006801:Humans; D008297:Male; D010076:Oxazepam / Q000494:pharmacology*; D051381:Rats; D013375:Substance Withdrawal Syndrome / Q000503:physiopathology*
D010076:Oxazepam