title: [Histological and histochemical changes in the kidneys of rabbits immunized with Cl. botulinum toxoid type B in combination with blood loss].
abstract: Immunization of rabbits with increasing doses of Cl. botulinum toxoid, type B, led to the development in the kidneys of a focal intracapillary productive glomerulonephritis, and also of productive endo- and perivasculites. Blood letting (in the amount of 1% of body weight) aggravated the morphological picture of the affection on account of supervention of the alternative and exudative components. At the same time blood letting led to reduction of the NAD-diaphorase, succinic dehydrogenase and glucose-6-phosphatase activity in the epithelium of the proximal portions of the nephrons.
mesh_terms: D000818:Animals; D001815:Bloodletting / Q000009:adverse effects*; D001905:Botulinum Toxins / Q000009:adverse effects*; D008058:Dihydrolipoamide Dehydrogenase / Q000378:metabolism; D004848:Epithelium / Q000201:enzymology; D005921:Glomerulonephritis / Q000201:enzymology / Q000209:etiology / Q000473:pathology*; D007114:Immunization; D007668:Kidney / Q000201:enzymology / Q000473:pathology; D011817:Rabbits; D013385:Succinate Dehydrogenase / Q000378:metabolism
chemical_list: D013385:Succinate Dehydrogenase; D008058:Dihydrolipoamide Dehydrogenase; D001905:Botulinum Toxins
vernacular_title: Gistologicheskie i gistokhimicheskie izmeneniia v pochkakh krolikov pri immunizatsii anatoksinom Cl. botulinum tipa B v sochetanii s krovopotereĭ