title: [Lysosomal enzyme activity in the serum of rats with experimental lead poisoning].
abstract: Examination of the effect of experimental lead poisoning on permeability of lysosomal membranes in albino rats demonstrated activation of lysosomal enzymes (alpha-manosidase and beta-acetylglucosaminidase) in the blood serum as soon as the third day after daily administration of lead acetate (20 mg/kg). Apparently damage of the lysosomal membrane played an important role in the pathogenesis of lead poisoning.
mesh_terms: D000118:Acetylglucosaminidase / Q000097:blood*; D000818:Animals; D004186:Disaccharidases / Q000097:blood*; D006596:Hexosaminidases / Q000097:blood*; D007855:Lead Poisoning / Q000097:blood / Q000201:enzymology*; D008247:Lysosomes / Q000378:metabolism*; D008297:Male; D008361:Mannosidases / Q000097:blood*; D010539:Permeability; D051381:Rats
chemical_list: D004186:Disaccharidases; D006596:Hexosaminidases; D008361:Mannosidases; D000118:Acetylglucosaminidase
vernacular_title: Aktovnost' lizosomal'nykh fermentov v syvorotke krovi drys pri éksperimentalńoĭ intoksikatsii svintsom