[Polycardiographic evaluation of cardiotoxic effects of rubidomycin in patients with acute leukemia].
In 6 out of 11 patients treated with rubidomycin deterioration of haemodynamic indices was observed including prolongation of the pressure rise subperiod, isometric contarction subperiod and reduction of mechanical index. These changes appeared already after the first administration of the drug and were followed in 4 cases by signs of circulatory failure.
D000208:Acute Disease; D000293:Adolescent; D000328:Adult; D003630:Daunorubicin / Q000009:adverse effects* / Q000627:therapeutic use; D006321:Heart / Q000187:drug effects*; D006333:Heart Failure / Q000139:chemically induced*; D006439:Hemodynamics / Q000187:drug effects; D006801:Humans; D007938:Leukemia / Q000188:drug therapy*; D008875:Middle Aged
D003630:Daunorubicin
Ocena polikardiograficzna kardiotoksycznego działania rubidomycyny u chorych z ostra białaczka