[Individual variation in the frequency of chromosome aberrations under the influence of chemical mutagens. I. Inter-cultural and inter-individual variations in the effect of mutagens on human lymphocytes].
The study of the distribution law of human peripheral blood cultures for the sensitivity to thiophosphamide was performed. In the first experiment the blood from one person was used, in the second one the blood was used from different persons. "The percent of aberrant cells" and "the number of chromosome breaks per 100 cells" were scored. The distribution law of the cultures in all the experiments was found to be normal. Analysis of the variances on the percent of aberrant cells showed that the distribution law of the cultures received from one donor corresponded to the binomial one, and that of the cultures received from different donors--to the Poisson's one.
D000477:Alkylating Agents / Q000633:toxicity*; D001388:Aziridines / Q000633:toxicity*; D001389:Azirines / Q000633:toxicity*; D002478:Cells, Cultured; D002869:Chromosome Aberrations; D014644:Genetic Variation; D006801:Humans; D008214:Lymphocytes; D009025:Morpholines / Q000633:toxicity; D009153:Mutagens
D000477:Alkylating Agents; D001388:Aziridines; D001389:Azirines; D009025:Morpholines; D009153:Mutagens
Individual'nye variatsii chastoty khromosomnykh aberratsiĭ pri deĭtvii khmicheskikh mutagenov. Soobshchenie I. Mezhkul'tural'nye i mezhindividual'nye variatsii pri deĭstvii mutagenov na limfotsity cheloveka