Exencephaly in fetal hamsters following exposure to hyperthermia.
Exposure of pregnant hamsters on gestation day 8 to 40 or 41 degrees C for one hour caused an increased rate of resorption and a high frequency of exencephaly and encephalocele. Longer exposures often killed pregnant females. Hamsters that had fetuses with abnormalities usually experienced body temperature elevations of 3-4 degrees C above normal (37 degrees C).
D000818:Animals; D001921:Brain / Q000002:abnormalities*; D000013:Congenital Abnormalities / Q000209:etiology*; D006224:Cricetinae; D004677:Encephalocele / Q000209:etiology; D005260:Female; D005334:Fever / Q000150:complications*; D005865:Gestational Age; D011247:Pregnancy; D013312:Stress, Physiological / Q000150:complications