A clinical study of anti-NDP in the sera of patients in a large repetitive hemodialysis program.
Anti-NDP has been detected in the sera of 38 of 430 patients on regular hemodialysis at the Regional Kidney Disease Program in Minneapolis. It developed in these patients from 7 to 58 months after commencement of dialysis. Bacterial infection appeared temporally related to the development of anti-NDP in 12 patients. Hemolytic episodes, possibly related to anti-NDP, occurred in 11. Fifty-five percent of the patients never reused dialyzers. The antibody preceded the insertion of a bovine graft in seven. We postulate that anti-NDP is recognizing an antigenic site similar to that recognized by Vicia graminea lectin, and that this site might become immunogenic by alteration of M and N antigens on red blood cell surfaces. Though formaldehyde might be involved in this alteration, dialysis membrane reuse does not seem to be required for the formation of anti-NDP.
D000328:Adult; D000368:Aged; D001323:Autoantibodies / Q000302:isolation & purification*; D004910:Erythrocyte Membrane / Q000276:immunology; D005260:Female; D006801:Humans; D008951:MNSs Blood-Group System; D008297:Male; D008567:Membranes, Artificial; D008875:Middle Aged; D006435:Renal Dialysis; D013997:Time Factors
D001323:Autoantibodies; D008951:MNSs Blood-Group System; D008567:Membranes, Artificial