title: A method of computing drug distribution in plasma using stepwise association constants: clofibrate acid as an illustrative example.
abstract: A program is described to compute the distribution of ligand among various complexes of ligand and protein using stepwise association constants. The key input data consists of stepwise association constants and the concentration of macromolecule and various concentrations of ligand. The key output data consists of the concentration of free drug and protein and the concentration of the various complexes.
mesh_terms: D002994:Clofibrate / Q000097:blood*; D003201:Computers; D006801:Humans; D008433:Mathematics; D011485:Protein Binding
chemical_list: D002994:Clofibrate