Biosynthesis of cadaverine in mice under the influence of an anabolic steroid.
The content of cadaverine (1,5-diaminopentane) in the kidney and urine was investigated in mice treated with the anabolic steroid Durabolin (nondrolone phenpropionate). After administration of this steroid cadaverine was found in the kidneys, whereas this amine could not be detected in the kidney of controls. The urinary excretion of cadaverine was elevated 50 times after Durabolin administration. An enzyme catalyzing the formation of cadaverine from lysine was shown for the first time to be present in mammalian tissue, namely in the kidney of mice after Durabolin administration.
D000818:Animals; D002103:Cadaverine / Q000096:biosynthesis* / Q000652:urine; D003959:Diamines / Q000096:biosynthesis*; D007668:Kidney / Q000378:metabolism*; D008239:Lysine / Q000378:metabolism; D008297:Male; D051379:Mice; D009277:Nandrolone / Q000494:pharmacology*
D003959:Diamines; D009277:Nandrolone; D008239:Lysine; D002103:Cadaverine