Potentiation of morphine-induced seizure by 6-hydroxydopamine.
The influence of 6-hydroxydopamine on morphine-induced convulsions were investigated in rats. Morphine, in doses up to 100 mg/kg did not produce any convulsive pattern in vehicle-pretreated rats. The pretreatment of rats by 6-hydroxydopamine strongly potentiated the seizure producing activity of morphine and the dose-response curve of seizure severity shifted to the right. These results suggest that brain catecholamines are involved in the mechanism of morphine-induced convulsions.
D000818:Animals; D004357:Drug Synergism; D006892:Hydroxydopamines / Q000494:pharmacology*; D008297:Male; D009020:Morphine / Q000494:pharmacology*; D051381:Rats; D012640:Seizures / Q000139:chemically induced*
D006892:Hydroxydopamines; D009020:Morphine