title: Specificity of sugar transport across the brush border of the rat proximal tubule.
abstract: By chemical and electrical measurements the transport of 25 sugars in the proximal tubule of the rat kidney was investigated. The data gained reveal the following structural requirements for the D-glucose transport system in the renal brush border: A free OH in the D-gluco-configuration on C atom 2 is most important - OH in equatorial position of the chair Cl conformation -. A free OH on C-3 in the equatorial configuration is also essential. If the OH on C-4 turns from the equatorial to the axial configuration the transport is 50% reduced. The OH on C-6 may be missing if otherwise the D-glucose configuration is unchanged. But if in addition the position of OH in C-4 has changed the transport ceases. Furthermore the presence of a C-6 atom and of a ring structure is necessary.
mesh_terms: D000818:Animals; D001692:Biological Transport; D001693:Biological Transport, Active; D003847:Deoxyglucose / Q000378:metabolism; D005947:Glucose / Q000378:metabolism; D007408:Intestinal Absorption; D007687:Kidney Tubules, Proximal / Q000378:metabolism*; D008757:Methylglucosides / Q000378:metabolism; D009005:Monosaccharides / Q000378:metabolism*; D051381:Rats; D013329:Structure-Activity Relationship
chemical_list: D008757:Methylglucosides; D009005:Monosaccharides; D003847:Deoxyglucose; D005947:Glucose