Contact sensitizing properties of some fatty acids in dermatophytes.
The predominant fatty acids (C10-C18) of dermatophytes were investigated by the Landsteiner-Draize test to establish their allergenicity. It was demonstrated that fatty acids can give rise to sensitization of delayed type in guinea pigs. The middle-chain fatty acids (C10-C12) showed a high allergenicity compared to the (C13-C18) acids with moderate to weak contact sensitizing properties. The fatty acids may act as contact sensitizers and, at least sometimes, be responsible for the skin lesions in dermatophytosis.
D000818:Animals; D003883:Arthrodermataceae / Q000276:immunology*; D003877:Dermatitis, Contact / Q000209:etiology*; D003881:Dermatomycoses / Q000276:immunology; D005227:Fatty Acids / Q000276:immunology*; D005260:Female; D006168:Guinea Pigs; D006968:Hypersensitivity, Delayed / Q000209:etiology*
D005227:Fatty Acids