Familial occurrence of gonadal tumors in XY females with breast development.
Three sisters with XY gonadal dysgenesis are presented. All of them have primary amenorrhea and breast development, and in two, a gonadal tumor, seminoma (dysgerminoma) was found. The danger of gonadal neoplasm in XY females with normal female build is emphasized.
D000293:Adolescent; D000328:Adult; D000568:Amenorrhea / Q000235:genetics; D001940:Breast / Q000254:growth & development; D004407:Dysgerminoma / Q000150:complications* / Q000235:genetics / Q000473:pathology; D005260:Female; D006066:Gonads / Q000473:pathology; D006801:Humans; D010641:Phenotype; D012730:Sex Chromosomes; D014424:Turner Syndrome / Q000150:complications* / Q000235:genetics