title: Dose-finding trials of oral oxamniquine in Rhodesia.
abstract: Oral oxamniquine at a total dose of 60 mg/kg (given in 4 equal doses morning and evening over 2 days, after food) is an efficient and apparently very safe drug for the treatment of Schistosoma mansoni infections. Lower doses, or shorter schedules of treatment, are less efficient. The drug has little or no effect on S. haematobium infections. Side-effects are mild and infrequent.
mesh_terms: D000293:Adolescent; D000328:Adult; D002648:Child; D002675:Child, Preschool; D004334:Drug Administration Schedule; D005260:Female; D006801:Humans; D008297:Male; D009600:Nitroquinolines / Q000008:administration & dosage*; D010073:Oxamniquine / Q000008:administration & dosage* / Q000009:adverse effects / Q000627:therapeutic use; D012548:Schistosoma haematobium; D012550:Schistosoma mansoni; D012552:Schistosomiasis / Q000188:drug therapy*
chemical_list: D009600:Nitroquinolines; D010073:Oxamniquine