title: Specificity of immediate skin reaction with streptokinase-streptodornase (SK-SD) in humans.
abstract: Streptokinase-streptodornase (SK-SD) induced immediate and delayed skin test reactions in a high proportion of patients with disorders in which beta-streptococcal infection may be involved. The P-K test and absorption experiments with antigen or anti-IgE suggested that the immediate reaction was mediated by specific IgE antibody against SK-SD. Furthermore, the ratio of specific IgE antibody against SK-SD to total IgE was roughly calculated to be 20 percent. Finally, the RAST technique was applied to detect specific IgE antibody against SK-SD which showed high radiocounts bound to SK-SD-coupled particles in the sera of nephrotic patients who had a strong immediate reaction against SK-SD and a severe disease state.
mesh_terms: D000328:Adult; D000918:Antibody Specificity; D000937:Antigen-Antibody Reactions; D002648:Child; D006801:Humans; D006969:Hypersensitivity, Immediate; D007116:Immunization, Passive; D007073:Immunoglobulin E; D011852:Radioallergosorbent Test; D012867:Skin / Q000276:immunology*; D012882:Skin Tests; D013299:Streptodornase and Streptokinase / Q000276:immunology*
chemical_list: D007073:Immunoglobulin E; D013299:Streptodornase and Streptokinase