Role of dopamine in the anorexigenic effect of DITA; comparison with d-amphetamine.
The effects of d,1-alpha-methyltyrosine (alphaMT), haloperidol, phenoxybenazmine, propranolol, methysergide and cyproheptadine on the anorexigenic activities of DITA and d-amphetamine were studied in male mice. The pretreatment of mice with methysergide (10 mg/kg, s.c.), cyproheptadine (5 mg/kg, i.p.), phenoxybenzamine (10 mg/kg, i.p.), and propranolol (5 mg/kg, i.p.) failed to alter the anorexigenic effect of DITA and d-amphetamine. On the other hand, alphaMT (32 mg/kg, i.p.) and haloperidol (0.5 mg/kg, i.p.) significantly antagonized the anorexigenic effect of DITA and d-amphetamine. Our data indicate that the anorexigenic activities of DITA and d-amphetamine are mediated mainly through the dopaminergic system.
D000098:Acetophenones / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D000818:Animals; D001067:Appetite Depressants / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D003533:Cyproheptadine / Q000494:pharmacology; D003913:Dextroamphetamine / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D004298:Dopamine / Q000378:metabolism*; D004435:Eating / Q000187:drug effects*; D006220:Haloperidol / Q000494:pharmacology; D007093:Imidazoles / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D008297:Male; D008781:Methyltyrosines / Q000494:pharmacology; D008784:Methysergide / Q000494:pharmacology; D051379:Mice; D010643:Phenoxybenzamine / Q000494:pharmacology; D011433:Propranolol / Q000494:pharmacology
D000098:Acetophenones; D001067:Appetite Depressants; D007093:Imidazoles; D008781:Methyltyrosines; D010643:Phenoxybenzamine; D003533:Cyproheptadine; C010919:DITA; D011433:Propranolol; D006220:Haloperidol; D003913:Dextroamphetamine; D004298:Dopamine; D008784:Methysergide