title: The treatment of pathological panic states with propranolol.
abstract: The authors report on the effects of propranolol, a beta-adrenergic blocking agent, on 10 patients with pathological panic states. Propranolol was effective in treating acute pathological panic, but modest doses of the drug administered for brief periods of time did not alleviate chronic panic attacks associated with agoraphobia. The drug suppressed panic associated with depressive syndromes but did not affect the depression and had no clear effect on anticipatory anxiety. The authors suggest that further study of these findings may clarify other clinical problems.
mesh_terms: D000208:Acute Disease; D000328:Adult; D000379:Agoraphobia / Q000188:drug therapy; D001008:Anxiety Disorders / Q000188:drug therapy; D002908:Chronic Disease; D003863:Depression / Q000188:drug therapy; D003865:Major Depressive Disorder / Q000188:drug therapy; D004305:Dose-Response Relationship, Drug; D005239:Fear / Q000187:drug effects*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010200:Panic / Q000187:drug effects*; D010698:Phobic Disorders / Q000188:drug therapy; D011433:Propranolol / Q000378:metabolism / Q000494:pharmacology / Q000627:therapeutic use*; D013997:Time Factors
chemical_list: D011433:Propranolol