title: Preleukemic states in the light of the leukemia cytokinetics.
abstract: On the basis of clonal development of leukemias, the beginning of the true preleukemias should antedate the overt leukemia by at least 37 doubling times (e.g., at least 4 years in the chronic granulocytic leukemia).
mesh_terms: D002455:Cell Division; D002999:Clone Cells; D006801:Humans; D011289:Preleukemia / Q000473:pathology*; D013997:Time Factors