title: Effects of rapid round trips against time displacement on adrenal cortical-medullary circadian rhythms.
abstract: The effects of rapid round trips against time displacement on circadian rhythms was investigated. The study was carried out on three occasions using one volunteer healthy physician on east-west trips (Tokyo-San Francisco-Tokyo) of short and prolonged stays. The control study was performed on a north-south trip (Tokyo-Sydney-Tokyo) which had practically no time displacement. The circadian rhythms of urinary 17-OHCS, 17-KS, and noradrenaline excretions and plasma cortisol in short-stay trips were disrupted and not synchronized; however, the recovery was rapid with the circadian rhythms returning to normal within 1 to 2 d. On the other hand, the circadian rhythms of these variables in the control study were not disrupted. These results suggest that a short, overnight stay during the trip minimizes the ill effects due to time displacement.
mesh_terms: D015068:17-Ketosteroids / Q000652:urine; D000302:Adrenal Cortex / Q000378:metabolism*; D000305:Adrenal Cortex Hormones / Q000652:urine; D000311:Adrenal Glands / Q000378:metabolism*; D000313:Adrenal Medulla / Q000378:metabolism*; D000328:Adult; D000337:Aerospace Medicine; D001683:Biological Clocks; D002940:Circadian Rhythm; D006801:Humans; D006854:Hydrocortisone / Q000097:blood; D008297:Male; D009638:Norepinephrine / Q000652:urine; D013997:Time Factors
chemical_list: D015068:17-Ketosteroids; D000305:Adrenal Cortex Hormones; D006854:Hydrocortisone; D009638:Norepinephrine