Cutaneous extramedullary hematopoiesis.
An asymptomatic skin nodule in a patient with myelofibrosis was shown to consist of extramedullary hematopoiesis. It was a soft bluish nodule that resembled a hemangioma. Microscopically, both erythroid and myeloid cells, but not megakaryocytes, were found. This case demonstrates the ability of the skin to recapitulate dermal hematopoiesis seen in a stage of human fetal development.
D000368:Aged; D006410:Hematopoiesis; D006801:Humans; D008297:Male; D011086:Polycythemia / Q000150:complications; D055728:Primary Myelofibrosis / Q000150:complications / Q000473:pathology* / Q000503:physiopathology; D012867:Skin / Q000473:pathology* / Q000503:physiopathology