title: Features of the immune response to DNA in mice. I. Genetic control.
abstract: The genetic control of the immune response to DNA was studied in various strains of mice F1 hybrids and corresponding back-crosses immunized with single stranded DNA complexed to methylated bovine serum albumin. Anti-DNA antibody response was measured by radioimmuno-logical technique. High responder, low responder, and intermediate responder strains were found and the ability to respond to DNA was characterized as a dominant genetic trait which is not linked to the major locus of histocompatibility. Studies in back-crosses suggested that this immune response is under multigenic control. High responder mice produce both anti-double stranded DNA and anti-single stranded DNA 7S and 19S antibodies, while low responder mice produce mainly anti-single stranded DNA 19S antibodies.
mesh_terms: D000818:Animals; D000917:Antibody Formation; D000918:Antibody Specificity; D000941:Antigens; D003433:Crosses, Genetic; D004247:DNA / Q000276:immunology*; D005260:Female; D005799:Genes, Dominant; D007074:Immunoglobulin G / Q000032:analysis; D007075:Immunoglobulin M / Q000032:analysis; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D012710:Serum Albumin, Bovine; D013045:Species Specificity
chemical_list: D000941:Antigens; D007074:Immunoglobulin G; D007075:Immunoglobulin M; D012710:Serum Albumin, Bovine; D004247:DNA