Halothane MAC in dogs unchanged by phenobarbital.
Halothane MAC in dogs was not significantly changed by phenobarbital (PB) therapy. Following 10 consecutive days of oral PB (10 mg/kg), halothane MAC was 0.95 +/- 0.05 vol/dl (mean +/- SE) compared with a halothane MAC of 1.05 +/- 0.03 vol/dl in another group not given PB. The absence of change in MAC may reflect either the development of tolerance to CNS sedative effects of PB or the masking of antanalgesia effects of the barbiturate by associated sedation and/or analgesia.
D000818:Animals; D004285:Dogs; D006221:Halothane / Q000032:analysis* / Q000097:blood; D010634:Phenobarbital / Q000494:pharmacology*; D011650:Pulmonary Alveoli; D014692:Ventilation-Perfusion Ratio / Q000187:drug effects*
D006221:Halothane; D010634:Phenobarbital