Intraurethral pressure response to the mucosal application of neuropharmacologic agent: an experiment study.
In an experimental canine model, topical application of phenylephrine hydrochloride (Neo-Synephrine) to the urethral mucosa was demonstrated to cause a rise of intraurethral pressure which persisted for over 2 h without any rise of arterial pressure. There was no intraurethral pressure change after the topical application of phentolamine (Regitine) or phenoxybenzamine (Dibenzyline). No effect was observed on the intraurethral pressure following isoprenaline (Isuprel) application, but a marked fall in arterial pressure was observed.
D000287:Administration, Topical; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D004285:Dogs; D005260:Female; D007545:Isoproterenol / Q000494:pharmacology; D008297:Male; D008954:Models, Biological; D009092:Mucous Membrane; D010643:Phenoxybenzamine / Q000494:pharmacology; D010646:Phentolamine / Q000494:pharmacology; D010656:Phenylephrine / Q000008:administration & dosage / Q000009:adverse effects / Q000494:pharmacology*; D011312:Pressure; D014521:Urethra / Q000187:drug effects* / Q000503:physiopathology
D010643:Phenoxybenzamine; D010656:Phenylephrine; D007545:Isoproterenol; D010646:Phentolamine