Release of chymotrypsin-like esterase from isolated rat peritoneal mast cells by arginine-rich calf thymus histone.
Release of chymotrypsin-like esterase from isolated rat peritoneal mast cells by arginine-rich and lysine-rich calf thymus histones was investigated. The arginine-rich histone released the esterase, but the lysine-rich histone did not release the esterase from the mast cells. The isolated mast cells spontaneously released the esterase gradually. The chymotrypsin-like esterase released from the mast cells is considered to digest the destructed material in tissues in a state of chronic destruction, such as chronically inflamed tissues and malignant tumours.
D000818:Animals; D001120:Arginine / Q000494:pharmacology; D001202:Ascitic Fluid / Q000166:cytology; D004950:Esterases / Q000378:metabolism*; D006657:Histones / Q000494:pharmacology*; D008239:Lysine / Q000494:pharmacology; D008407:Mast Cells / Q000201:enzymology / Q000378:metabolism*; D051381:Rats; D013950:Thymus Gland; D014443:Tyrosine / Q000031:analogs & derivatives
D006657:Histones; D014443:Tyrosine; D001120:Arginine; D004950:Esterases; D008239:Lysine