title: Strongyle infections in ponies. I. Response to intermittent thiabendazole treatments.
abstract: A group of seven ponies naturally infected with large numbers of small strongyles and raised under conditions to minimize reinfection were treated periodically over a three year span with thiabendazole at the rate of 44 mg/kg body weight. Based on the absence of worm eggs in the feces following each treatment, thiabendazole removed the adult strongyles present with a new population subsequently developing by maturation of inhibited larvae. It took as many as four or five treatments to eliminate or reduce significantly the worm burdens present in the ponies under the conditions of this study. Strongyle eggs started to reappear in the feces about six weeks after treatment and following the first treatment the mean egg counts rose to the pretreatment level. On successive treatments the interval for worm eggs to appear in the feces lengthened and mean egg counts never rose quite as high as immediate pretreatment levels. Hematological changes were not marked, although a small steady increase in the mean hemoglobin values and an equivalent small decrease in the mean eosinophil counts occurred in all ponies following each successive treatment. The study supports the rationale of regular anthelmintic treatment of horses in that even in the absence of reinfection, new burdens of adult worms develop following treatment.
mesh_terms: D000818:Animals; D005243:Feces / Q000469:parasitology; D005260:Female; D006736:Horses; D008297:Male; D010270:Parasite Egg Count; D013319:Strongyle Infections, Equine / Q000188:drug therapy* / Q000469:parasitology; D013827:Thiabendazole / Q000008:administration & dosage* / Q000627:therapeutic use; D013997:Time Factors
chemical_list: D013827:Thiabendazole