Impairment of Hebb-Williams maze performance following prolonged alcohol consumption in rats.
Wistar rats consumed a liquid diet containing sustagen and ethanol for a period of 150 days. Control animals were pair-fed an identical diet except for isocaloric substitution of sucrose for ethanol. Forty-five days after the liquid diets were discontinued both groups were tested for performance on the Hebb-Williams maze. The experimental group made significantly more errors than the control group indicating that long-term ingestion of alcohol can lead to substantial impairment of problem-solving abilities in rats.
D000428:Alcohol Drinking; D000818:Animals; D004032:Diet; D004334:Drug Administration Schedule; D000431:Ethanol / Q000008:administration & dosage / Q000494:pharmacology*; D008297:Male; D008570:Memory, Short-Term / Q000187:drug effects; D011340:Problem Solving / Q000187:drug effects*; D051381:Rats
D000431:Ethanol