Fracture healing in the presence of chronic hypoxia.
Recent studies have demonstrated that fracture healing normally takes place under hypoxic conditions. The present study evaluated the effect of a state of chronic systemic hypoxia on fracture healing in dogs. A significant delay in fracture healing was demonstrated in the hypoxic animals roentgenographically, histologically, and by strength-testing criteria. A further reduction in the available oxygen supply below that present during normal repair had an adverse effect on fracture healing.
D000818:Animals; D004285:Dogs; D005260:Female; D005360:Fibula / Q000000981:diagnostic imaging / Q000473:pathology; D050723:Fractures, Bone / Q000000981:diagnostic imaging / Q000378:metabolism* / Q000473:pathology; D000860:Hypoxia / Q000378:metabolism*; D008297:Male; D010100:Oxygen; D010101:Oxygen Consumption; D011859:Radiography; D013718:Tensile Strength; D014945:Wound Healing
D010100:Oxygen