The effect of anti-parkinsonian drugs on chlorpromazine-induced depression of operant behaviour.
Rats were conditioned in automatic Skinner boxes on a discrete trial avoidance-escape schedule. The chlorpromazine-induced conditioned reflex inhibition could be reversed by apomorphine and amantadine, but not by atropine, trihexyphenidyl and diethazine. These findings seem to provide an additional tool for differentiating the atropine-like and dopaminergic anti-parkinsonian drugs.
D000547:Amantadine / Q000008:administration & dosage / Q000494:pharmacology; D000818:Animals; D000978:Antiparkinson Agents / Q000494:pharmacology*; D001058:Apomorphine / Q000008:administration & dosage / Q000494:pharmacology; D001285:Atropine / Q000008:administration & dosage / Q000494:pharmacology; D001522:Behavior, Animal / Q000187:drug effects*; D002746:Chlorpromazine / Q000008:administration & dosage / Q000494:pharmacology; D003216:Conditioning, Operant / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D008297:Male; D010640:Phenothiazines / Q000008:administration & dosage / Q000494:pharmacology; D051381:Rats; D014282:Trihexyphenidyl / Q000008:administration & dosage / Q000494:pharmacology
D000978:Antiparkinson Agents; D010640:Phenothiazines; D014282:Trihexyphenidyl; D001285:Atropine; D000547:Amantadine; D001058:Apomorphine; D002746:Chlorpromazine