title: Inhibition of prothrombin synthesis and epoxidation of vitamin K1 by anticoagulants in vitro.
mesh_terms: D000818:Animals; D000925:Anticoagulants / Q000494:pharmacology*; D003374:Coumarins / Q000494:pharmacology; D003600:Cytosol / Q000187:drug effects / Q000378:metabolism; D004852:Epoxy Compounds / Q000378:metabolism*; D004988:Ethers, Cyclic / Q000378:metabolism*; D007189:Indans / Q000494:pharmacology; D007700:Kinetics; D008099:Liver / Q000378:metabolism*; D008862:Microsomes, Liver / Q000187:drug effects / Q000378:metabolism*; D011516:Prothrombin / Q000096:biosynthesis*; D051381:Rats; D013329:Structure-Activity Relationship; D014812:Vitamin K / Q000378:metabolism*
chemical_list: D000925:Anticoagulants; D003374:Coumarins; D004852:Epoxy Compounds; D004988:Ethers, Cyclic; D007189:Indans; D014812:Vitamin K; D011516:Prothrombin