Effect of aggregated human gamma-globin on leukocyte migration-inhibitory test in patients with rheumatoid arthritis.
In 69 patients with rheumathoid arthritis (RA): 49 sero-positive and 20 sero-negative for rheumatoid factor and in a group of 20 healthy blood donors the leukocyte migration-inhibitory test was carried out. Heat-aggregated gamma-globulin was used in the culture medium as antigen. Both groups of patients exhibited a significant inhibition of migration, as compared with the group of healthy subjects. However, a significant difference in the mean value of the migration indices between the sero-positive and sero-negative individuals was observed.
D001172:Arthritis, Rheumatoid / Q000276:immunology*; D002464:Cell Migration Inhibition; D004306:Dose-Response Relationship, Immunologic; D005260:Female; D006801:Humans; D007074:Immunoglobulin G; D008297:Male
D007074:Immunoglobulin G