Effect of lead on glycine cleavage activity in rat liver mitochondria.
Change of glycine cleavage activity in liver mitochondria of lead-intoxicated rats was studied in this paper. The following results were obtained: (1) The activity in hepatic mitochondria of rats was decreased by a single administration of lead (4 mg/100 g body weight); (2) in vitro the activity in the normal rat liver mitochondria was markedly inhibited by addition of lead acetate (4mM).
D000622:Aminolevulinic Acid / Q000378:metabolism; D000818:Animals; D005998:Glycine / Q000378:metabolism*; D007854:Lead / Q000494:pharmacology*; D008297:Male; D008930:Mitochondria, Liver / Q000187:drug effects / Q000378:metabolism*; D051381:Rats; D013997:Time Factors
D007854:Lead; D000622:Aminolevulinic Acid; D005998:Glycine