Oxonic acid and fetal development: II. Teratogenicity in rats.
Feeding the uricase inhibitor potassium oxonate (KOx) as 3% of the diet to pregnant rats beginning on the 8th day of gestation for either 2 or 3 days caused a time-related increase in fetal resorptions, with the incidence in the experimental group treated for the additional day being 72% higher than the 2-day group. The shorter treatment period permitted more rat fetuses to survive to term; however 9.3% of these showed gross malformations, exencephaly and/or visceral herniation. Thus, KOx is demonstrated to be both embryotoxic and teratologic in the rat.
D000818:Animals; D005260:Female; D005313:Fetal Death / Q000139:chemically induced; D005333:Fetus / Q000187:drug effects*; D010094:Oxonic Acid / Q000633:toxicity*; D011247:Pregnancy; D051381:Rats / Q000196:embryology*; D013723:Teratogens; D014227:Triazines / Q000633:toxicity*
D013723:Teratogens; D014227:Triazines; D010094:Oxonic Acid