Effect of short- and long-term treatment with cocaine on rat brain tryptophan hydroxylase.
Short-term (5 days) treatment with cocaine (10 mg/kg, i.p.) inhibited the soluble tryptophan hydroxylase while the particulate enzyme was essentially unchanged. In contrast, long-term (45 days) treatment resulted in an increased activity of the particulate enzyme and a return to normal of the soluble enzyme activity.
D000818:Animals; D001921:Brain / Q000187:drug effects* / Q000201:enzymology; D003042:Cocaine / Q000008:administration & dosage / Q000494:pharmacology*; D004334:Drug Administration Schedule; D008297:Male; D006899:Mixed Function Oxygenases / Q000378:metabolism*; D051381:Rats; D014365:Tryptophan Hydroxylase / Q000378:metabolism*
D006899:Mixed Function Oxygenases; D014365:Tryptophan Hydroxylase; D003042:Cocaine