Systems approach to vaginal delivery of drugs II: In situ vaginal absorption of unbranched aliphatic alcohols.
The absorption of unbranched aliphatic alcohols in the rabbit vagina was studied using a perfusion method, and the absorption rates were found to be first order with respect to the drug concentration in the vagina from methanol to octanol. A physical model involving an aqueous diffusion layer in series with a membrane consisting of aqueous pores and lipoidal pathways was used for analyzing the data. The physically based parameters in the model were determined. An effective diffusion layer thickness ("unstirred layer") of around 0.035 cm was found. The increase in the permeability coefficient for the lipoidal pathway per methylene group was around 2.5 for this homologous series.
D000042:Absorption; D000438:Alcohols / Q000008:administration & dosage / Q000378:metabolism*; D000818:Animals; D002462:Cell Membrane / Q000378:metabolism; D004058:Diffusion; D005260:Female; D007700:Kinetics; D008954:Models, Biological; D010477:Perfusion; D010539:Permeability; D004364:Pharmaceutical Preparations / Q000008:administration & dosage*; D011817:Rabbits; D013329:Structure-Activity Relationship; D014621:Vagina / Q000378:metabolism* / Q000648:ultrastructure
D000438:Alcohols; D004364:Pharmaceutical Preparations