[Mitochondrial respiration and the state of adenine nucleotide phosphorylation in rat liver following multiple administration of 3-methylcholanthrene and phenobarbital].
After 4 injections of phenobarbital (PB), 3-methylcholantrene in olive oil (MC) or olive oil alone the corresponding concentrations of acyl-CoAs in the liver (in per cent to control) were: 73, 167, 230. The liver mitochondria from rats injected with oil and MC showed inhibition of the metabolic state 3 respiratory rate after Chance, Preincubation with carnitine elimated this inhibition. In accordance with these data the blood ketone body level in the administration of PB, MC and oil were 31, 136, and 342%, respectively. The phosphate potential value declined only after the injections of olive oil when the ATP concentration in the liver was markedly diminished. The AMP concentration doubled in the liver of rats after the PB and oil injection. Comparison of the data on the induction of microsomal monoxigenases by PB and MC permitted to draw a conclusion that there was a different metabolic fate of acyl-CoAs in these two cases.
D000244:Adenosine Diphosphate / Q000378:metabolism; D000249:Adenosine Monophosphate / Q000378:metabolism; D000255:Adenosine Triphosphate / Q000378:metabolism; D000818:Animals; D003065:Coenzyme A / Q000378:metabolism; D007657:Ketone Bodies / Q000378:metabolism; D008099:Liver / Q000378:metabolism*; D008297:Male; D008748:Methylcholanthrene / Q000494:pharmacology*; D008930:Mitochondria, Liver / Q000378:metabolism; D010101:Oxygen Consumption / Q000187:drug effects; D010634:Phenobarbital / Q000494:pharmacology*; D051381:Rats; D013438:Sulfhydryl Compounds / Q000378:metabolism
D007657:Ketone Bodies; D013438:Sulfhydryl Compounds; D000249:Adenosine Monophosphate; D008748:Methylcholanthrene; D000244:Adenosine Diphosphate; D000255:Adenosine Triphosphate; D003065:Coenzyme A; D010634:Phenobarbital
Dykhanie mitokhondriĭ i sostoianie fosforilirovaniia adeninnukleotidov pecheni krys pri mnogokratnom vvedenii 3-metilkholantrena i fenobarbitals