[Criteria selection for the preliminary evaluation of the efficacy of antihypoxic agents].
Mathematical description is suggested of oxygen consumption by mitochondria suspension in the presence of orto-benzoquinone derivatives. An analysis of the equations obtained, in vivo conditions taken into account, has shown that the efficiency of hydrogen consumption is mainly determined by the constant value of oxidation rate of quinone reduced form, poorely depends on the substrate concentration and activity of quinone-reducing enzymes. The constant value of oxidation rate may serve as a criterion of directed synthesis of antihypoxants.
D004353:Drug Evaluation, Preclinical; D000860:Hypoxia / Q000188:drug therapy*; D008433:Mathematics; D008930:Mitochondria, Liver / Q000187:drug effects; D008954:Models, Biological; D010101:Oxygen Consumption / Q000187:drug effects; D011809:Quinones / Q000627:therapeutic use*
D011809:Quinones
K voprosu o vybore kriteriev predvaritel'noĭ otsenki éffektivnosti antigipoksantov