Group A streptococcal infections as related to rheumatic fever.
Beta-hemolytic streptococci were recovered frequently, particularly from the throats of children, and the same type of group A strains was isolated from both throats and tonsils. A significant antibody response to streptolysin O was observed in 44.8 to 43.5 % of the children whom group A streptococci were recovered. It is considered that these children had the definite evidence of acute streptococcal infections, and administration of josamycin, penicillin G, and benzyl penicillin V benzathine decreases the frequency of recovery of beta-hemolytic streptococci and prevents rheumatic fever.
D000328:Adult; D000367:Age Factors; D000907:Antibodies, Bacterial / Q000032:analysis; D000989:Antistreptolysin / Q000378:metabolism; D002648:Child; D002908:Chronic Disease; D005500:Follow-Up Studies; D006801:Humans; D014066:Palatine Tonsil / Q000382:microbiology; D010614:Pharynx / Q000382:microbiology; D012213:Rheumatic Fever / Q000209:etiology* / Q000276:immunology / Q000382:microbiology; D013290:Streptococcal Infections / Q000150:complications*; D013291:Streptococcus / Q000302:isolation & purification; D014069:Tonsillitis / Q000382:microbiology
D000907:Antibodies, Bacterial; D000989:Antistreptolysin