Macrophage plasminogen activator: induction by asbestos is blocked by anti-inflammatory steroids.
Intraperitoneal injection of asbestos fibres into mice induces the formation of exudates containing macrophages that produce plasminogen activator. Like-wise, in vitro addition of asbestos to macrophage cultures stimulates plasminogen activator secretion; the synthesis and secretion of lysozyme and lysosomal enzymes are not changed under these conditions. The enhanced secretion of plasminogen activator by macrophages exposed to asbestos is suppressed by low concentrations of anti-inflammatory steroids.
D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology*; D001194:Asbestos / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D001202:Ascitic Fluid / Q000166:cytology; D002478:Cells, Cultured; D003907:Dexamethasone / Q000494:pharmacology; D004731:Endotoxins / Q000494:pharmacology; D008247:Lysosomes / Q000201:enzymology; D008264:Macrophages / Q000378:metabolism*; D051379:Mice; D009113:Muramidase / Q000378:metabolism; D010960:Plasminogen Activators / Q000096:biosynthesis* / Q000378:metabolism; D013864:Thioglycolates / Q000494:pharmacology
D000893:Anti-Inflammatory Agents; D004731:Endotoxins; D013864:Thioglycolates; D001194:Asbestos; D003907:Dexamethasone; D009113:Muramidase; D010960:Plasminogen Activators