Sorbistin, a new aminoglycoside antibiotic complex of bacterial origin. I. Production, isolation and properties.
A strain of a new Pseudomonas species produced the aminoglycoside antibiotic complex, sorbistin, which was separated by ion-exchange chromatography into three bio-active components A1, A2 and B, and two bio-inactive components C and D. Sorbistins A1, A2 and B showed moderate intrinsic activity against a wide range of bacterial species and inhibited most of the aminoglycoside-resistant organisms. Sorbistin A1 exhibited the highest activity among the three bio-active components. Sorbistins showed low order of acute toxicity in mice.
D000617:Aminoglycosides / Q000032:analysis / Q000096:biosynthesis / Q000494:pharmacology; D000818:Animals; D000900:Anti-Bacterial Agents / Q000032:analysis / Q000096:biosynthesis / Q000494:pharmacology; D001419:Bacteria / Q000187:drug effects; D001424:Bacterial Infections / Q000188:drug therapy; D055598:Chemical Phenomena; D002621:Chemistry; D005285:Fermentation; D007928:Lethal Dose 50; D051379:Mice; D011549:Pseudomonas / Q000378:metabolism
D000617:Aminoglycosides; D000900:Anti-Bacterial Agents