[Change in the metabolism and toxic effect of benz(a)pyrene by its metabolites and a series of phenols].
Effects of some phenols and polycyclic aromatic hydrocarbon derivatives on benz(a)-pyrene metabolism have been studied in the microsomal system isolated from the mouse embryonic cell cultures. The rate of benz(a)pyrene metabolism was shown to depend on the structure and concentration of the agents added. The toxic effect of benz(a)pyrene was summed up with that of either agent studied (except ionol) added simultaneously to the cell culture.
D000818:Animals; D001580:Benzopyrenes / Q000378:metabolism* / Q000494:pharmacology / Q000633:toxicity; D002478:Cells, Cultured; D005347:Fibroblasts; D051379:Mice; D008861:Microsomes / Q000378:metabolism; D010084:Oxidation-Reduction; D010636:Phenols / Q000494:pharmacology*
D001580:Benzopyrenes; D010636:Phenols
Izmenenie metabolizma i toksicheskogo deĭstviia benz(a)pirena s pomoshch'iu ego metabolitov i riada fenolov