title: [Change in the activity of the enzymatic systems of rabbit macrophages following injuries to several hypothalamic nuclei (histochemical study)].
abstract: The authors conducted a histochemical study of the activity of some lysosomal and redox enzymes of the peritoneal macrophages in injury of the structures of the anterior and the posterior hypothalamus. Bilateral coagulation of the posterior hypothalamic nucleus proved to be accompanied by increase in the activity of the lysosomal enzymes and a corresponding reduction in the activity of the redox enzymes on the 10th and the 21st postoperative days. The activity of lysosomal enzymes decreased and of the redox--rose on the 15th postoperative day. A reduction in the activity of the lysosomal enzymes was observed on the 10th and the 15th days after the supraoptic nucleus coagulation; by the 21st day it was replaced by a marked increase in their activity. A conclusion was drawn that an important role in the regulation of the macrophage function and of their lysosomal apparatus belonged to the hypothalamus.
mesh_terms: D000135:Acid Phosphatase / Q000378:metabolism; D000469:Alkaline Phosphatase / Q000378:metabolism; D000818:Animals; D003851:Deoxyribonucleases / Q000378:metabolism; D008058:Dihydrolipoamide Dehydrogenase / Q000378:metabolism; D004950:Esterases / Q000378:metabolism; D005966:Glucuronidase / Q000378:metabolism; D006651:Histocytochemistry; D007031:Hypothalamus / Q000502:physiology*; D007034:Hypothalamus, Posterior / Q000502:physiology*; D008247:Lysosomes / Q000201:enzymology; D008264:Macrophages / Q000201:enzymology*; D008297:Male; D011817:Rabbits; D013385:Succinate Dehydrogenase / Q000378:metabolism; D013495:Supraoptic Nucleus / Q000502:physiology*
chemical_list: D013385:Succinate Dehydrogenase; D008058:Dihydrolipoamide Dehydrogenase; D003851:Deoxyribonucleases; D004950:Esterases; D000469:Alkaline Phosphatase; D000135:Acid Phosphatase; D005966:Glucuronidase
vernacular_title: Izmenenie aktivnosti énzimaticheskikh sistem krolich'ikh makrofagov pri povrezhdenii nekotorykh iadergipotalamusa (gistokhimicheskoe isseldovanie)