Hepatic inactivation of renin in the treatment of hyperreninemic hypertension.
The concept of the hepatic inactivation of renin secreted by the juxtaglomerular apparatuses of the ischemic kidney was used for reversal of hypertension in dogs. In three dogs, the left renal artery was constricted, and a significant and well established hyperreninemic hypertension was recorded. The performance of an end-to-end splenorenal shunt following renal artery constriction reversed the hyperreninemia and hypertension. Shunting of the renal venous drainage into the portal system prior to constriction of the main renal artery prevented, as demonstrated by the limited data available, the development of hyperreninemic hypertension.
D000818:Animals; D001794:Blood Pressure; D003250:Constriction; D004285:Dogs; D005260:Female; D006977:Hypertension, Renal / Q000097:blood* / Q000503:physiopathology / Q000601:surgery; D008297:Male; D011169:Portal Vein / Q000601:surgery*; D012077:Renal Artery / Q000601:surgery; D012082:Renal Veins / Q000601:surgery*; D012083:Renin / Q000097:blood*; D013162:Splenic Vein / Q000601:surgery*
D012083:Renin