title: [Experimental morphological study of the vaccination process following aerosol application of lyophilized live influenza A2/Hong Kong and B/USSR vaccines].
abstract: A comparative study of immunologic, immunomorphological and morphological responses of the viscera of white rats immunized by aerosol intranasally with lyophilized influenza A2/Hong Kong and B/USSR vaccines with an adjuvant (typhoid antigen) and without it was carried out. Also lung tissues were examined for intracellular inclusions considered to be a morphological indication of influenza virus implantation. No pathological lesions were found in the organs of the immunized animals. It is concluded that the intensity of immunologic and immuno-morphological responses depends upon the method of vaccine application and upon vaccine type but not upon the adjuvant.
mesh_terms: D000276:Adjuvants, Immunologic; D000281:Administration, Intranasal; D000336:Aerosols; D000818:Animals; D000914:Antibodies, Viral / Q000032:analysis; D005612:Freeze Drying; D007252:Influenza Vaccines / Q000008:administration & dosage; D008168:Lung / Q000382:microbiology; D009928:Organ Specificity; D009975:Orthomyxoviridae / Q000276:immunology* / Q000302:isolation & purification; D051381:Rats; D014611:Vaccination
chemical_list: D000276:Adjuvants, Immunologic; D000336:Aerosols; D000914:Antibodies, Viral; D007252:Influenza Vaccines
vernacular_title: Eksperimental'no-morfologicheskoe issledovanie vaktsinnogo protsessa pri aérozol'nom primenenii zhivykh sukhikh protivogrippoznikh vaktsii tipa A2/Honkong i B/SSSR