Mazindol anorexia is mediated by activation of dopaminergic mechanisms.
1 Anorexia in rats following injections of mazindol (0.1-8 mg/kg i.p.) could be antagonized by pretreatment with a dopamine receptor blocker (primozide) but not by pretreatment with an alpha-adrenoceptor blocker (phenoxybenzamine), a beta-adrenoceptor blocker ((-)-propranolol), or a 5-hydroxytryptamine receptor blocker (methergoline). 2 In rats with a unilateral lesion in the substantia nigra made by stereotaxic injection of 6-hydroxydopamine, mazindol caused a dose-dependent turning towards the lesioned side, indicating an indirect mechanism of action. This effect could be antagonized by pretreatment with a dopamine receptor blocker. 3 In rats pretreated with reserpine and alpha-methyl-p-tyrosine, mazindol did not have any motor stimulant action. 4 In vitro studies with synaptosomes prepared from rat brain, indicated that mazindol blocks uptake and causes release of dopamine. 5 It is concluded that the anorectic action of mazindol is mediated by a dopaminergic mechanism.
D000818:Animals; D001067:Appetite Depressants; D001522:Behavior, Animal / Q000187:drug effects; D003342:Corpus Striatum / Q000648:ultrastructure; D004298:Dopamine / Q000378:metabolism / Q000502:physiology*; D005247:Feeding Behavior / Q000187:drug effects*; D006892:Hydroxydopamines / Q000494:pharmacology; D066298:In Vitro Techniques; D007211:Indoles / Q000494:pharmacology*; D008297:Male; D008454:Mazindol / Q000494:pharmacology*; D008781:Methyltyrosines / Q000494:pharmacology; D051381:Rats; D012110:Reserpine / Q000494:pharmacology; D013378:Substantia Nigra / Q000187:drug effects; D013574:Synaptosomes / Q000378:metabolism; D013997:Time Factors
D001067:Appetite Depressants; D006892:Hydroxydopamines; D007211:Indoles; D008781:Methyltyrosines; D012110:Reserpine; D008454:Mazindol; D004298:Dopamine