title: [Side reaction after lumbar myelography with dimer-x (author's transl)].
abstract: The existence of several very impressive spinal paroxysms after lumbar myelography with Dimer-X1 caused us to make a retrospective investigation of 327 patients with 355 myelographies. In 7.1% of the investigations we have found partly heavy, but mostly reversible neurological complications. The latter cannot be classified, contrary to prevailing statements, in spinal, meningeal or cerebral reactions, since mostly all 3 anatomical structures are being concerned. Corresponding casuistical information are being presented and with their neurological symptomatic discussed. The spinal paroxysms appeared approximately 6 hours after the myelography and lasted over 8-10 hours, in spite of intensive therapeutical efforts. The pathogenesis points to a multifactorial occurrence caused by the coincidence of an increased dosage of the contrast media, too bed rest time, rising of the contrast media in the spinal cord zone and disturbed liquor fluid circulation and contrast media resorption. Pathophysiologically is in connection with spinal cramps an epileptic mechanism probable. Additional spinal reflexive components could be an explanation for the little therapeutical effect of Diacepam (Valium), which is contrary to the statement in the literature. We have seen a better effect in particular cases with Phenothiazine. With strict observance of specific precautionary measures, the Dimer-X seems to be a good media for the presentation of the lumbar subarachnoid space. A further development in this field is desirable.
mesh_terms: D000293:Adolescent; D000328:Adult; D003975:Diazepam / Q000627:therapeutic use; D004827:Epilepsy / Q000139:chemically induced; D005260:Female; D006801:Humans; D007483:Iothalamic Acid / Q000009:adverse effects / Q000031:analogs & derivatives*; D008159:Lumbar Vertebrae; D008297:Male; D008875:Middle Aged; D009192:Myelography; D010640:Phenothiazines / Q000627:therapeutic use; D012640:Seizures / Q000139:chemically induced / Q000188:drug therapy; D013997:Time Factors
chemical_list: D010640:Phenothiazines; D007483:Iothalamic Acid; D003975:Diazepam
vernacular_title: Nebenreaktionen nach lumbaler Myelographie mit Dimer-X