title: The preleukemic syndrome: clinical and laboratory features, natural course, and management.
abstract: The clinical and laboratory features of the stages in the evolution of acute nonlymphocytic leukemia are reviewed. Based on a retrospective analysis of 34 patients who died with an acute myelomonoblastic leukemia, the "preleukemic syndrome" has been shown to display a clinical picture sufficiently specific to permit its recognition prospectively (i.e., before the development of overt leukemia). The results to date of a variety of prospective studies are reviewed, and the approach(es) to the management of these cases is considered.
mesh_terms: D000305:Adrenal Cortex Hormones / Q000627:therapeutic use; D000368:Aged; D000728:Androgens / Q000627:therapeutic use; D000964:Antimetabolites, Antineoplastic / Q000627:therapeutic use; D001803:Blood Transfusion; D001854:Bone Marrow Cells; D004913:Erythrocytes, Abnormal / Q000166:cytology; D005492:Folic Acid / Q000627:therapeutic use; D006098:Granulocytes / Q000166:cytology; D006801:Humans; D008297:Male; D008533:Megakaryocytes / Q000166:cytology; D008875:Middle Aged; D011289:Preleukemia / Q000175:diagnosis* / Q000628:therapy; D012189:Retrospective Studies; D013156:Splenectomy; D014805:Vitamin B 12 / Q000627:therapeutic use
chemical_list: D000305:Adrenal Cortex Hormones; D000728:Androgens; D000964:Antimetabolites, Antineoplastic; D005492:Folic Acid; D014805:Vitamin B 12