Competition between the induction of hepatic protein synthesis by drugs and inhibition by actinomycin D indicating a mechanism for decreased acute toxicity in vio apparently independent of stimulated drug metabolism.
D000818:Animals; D003609:Dactinomycin / Q000494:pharmacology* / Q000633:toxicity; D005260:Female; D006529:Hepatomegaly / Q000139:chemically induced / Q000378:metabolism; D008099:Liver / Q000378:metabolism*; D010634:Phenobarbital / Q000494:pharmacology*; D014176:Protein Biosynthesis / Q000187:drug effects*; D051381:Rats; D014158:Transcription, Genetic / Q000187:drug effects
D003609:Dactinomycin; D010634:Phenobarbital