The adenosine triphosphate (ATP) depletion test: comparison with the caffeine contracture test as a method of diagnosing malignant hyperthermia susceptibility.
The adenosine triphosphate (ATP depletion ratio, which is the ratio [ATP] in skeletal muscle equilibrated with carbogen and 4% halothane for 30 minutes divided by [ATP] in skeletal muscle equilibrated with carbogen alone for 30 minutes is less than normal in most but not in all rigid MHS patients. The ratio is normal in non-rigid MHS patients. This diagnostic tool is, therefore, useful in the diagnosis of rigid MH. It is not, however, such a sensitive diagnostic parameter as the caffeine contracture test.
D000255:Adenosine Triphosphate; D000293:Adolescent; D000328:Adult; D000368:Aged; D001706:Biopsy; D002110:Caffeine / Q000494:pharmacology; D002245:Carbon Dioxide / Q000494:pharmacology; D002648:Child; D004305:Dose-Response Relationship, Drug; D006221:Halothane / Q000494:pharmacology; D006801:Humans; D008305:Malignant Hyperthermia / Q000175:diagnosis* / Q000235:genetics / Q000378:metabolism; D008875:Middle Aged; D009119:Muscle Contraction / Q000187:drug effects; D009129:Muscle Tonus / Q000187:drug effects; D009132:Muscles / Q000378:metabolism; D010100:Oxygen / Q000494:pharmacology
D002245:Carbon Dioxide; D002110:Caffeine; D000255:Adenosine Triphosphate; D010100:Oxygen; D006221:Halothane