Preweanling rats: recovery from lateral hypothalamic damage.
Preweanling male and female albino rats sustained lateral hypothalamic area (LHA) destruction at 10 days of age. Pups with bilateral LHA destruction (Bi-LHA) displayed the lateral hypothalamic recovery syndrome (LHRS) and recovered voluntary feeding and drinking between 44-75 days of age. The Bi-LHA rats of both sexes showed permanent deficits (through 200-275 days of age) in responding to hydrational challenges and did not feed in response to 2-deoxy-D-glucose treatment. Male Bi-LHA rats' body weights were permanently depressed by 20%-25%, whereas female body weight depression was only temporary. Rats sustaining LHA destruction on one side of the brain (Uni-LHA) displayed an abbreviated LHRS, recovering voluntary feeding and drinking by 25-32 days of age. The Uni-LHA rats showed some permanent deficits in responding to hydrational challenges, yet they displayed the same sex differential for body weight regulation as the Bi-LHA rats. The results of this investigation demonstrate nearly identical effects of LHA destruction whether sustained preweaning, postweaning, or during adulthood.
D000367:Age Factors; D000818:Animals; D001835:Body Weight; D003847:Deoxyglucose / Q000494:pharmacology; D004327:Drinking Behavior / Q000187:drug effects / Q000502:physiology; D005247:Feeding Behavior / Q000187:drug effects / Q000502:physiology; D005260:Female; D007839:Functional Laterality; D007031:Hypothalamus / Q000502:physiology*; D008297:Male; D011092:Polyethylene Glycols / Q000494:pharmacology; D051381:Rats; D012737:Sex Factors; D012965:Sodium Chloride / Q000494:pharmacology; D014868:Water Deprivation; D014886:Weaning
D011092:Polyethylene Glycols; D012965:Sodium Chloride; D003847:Deoxyglucose