Activation by cholera toxin of adenylate cyclase solubilized from rat liver.
Cholera toxin, or peptide A1 from the toxin, activates adenylate cyclase solubilized from rat liver with Lubrol PX, provided that cell sap, NAD+, ATP and thiol-group-containing compounds are present. The activation is abolished by antisera to whole toxin, but not to subunit B.
D000262:Adenylyl Cyclases / Q000378:metabolism*; D000818:Animals; D001427:Bacterial Toxins / Q000494:pharmacology*; D004789:Enzyme Activation; D008099:Liver / Q000201:enzymology*; D010446:Peptide Fragments / Q000494:pharmacology; D051381:Rats; D014734:Vibrio cholerae
D001427:Bacterial Toxins; D010446:Peptide Fragments; D000262:Adenylyl Cyclases