[The uterotropismus of halothane, chloroform or methoxyflurane in clinical use (author's transl)].
To perform episiotomy, 89 women after childbirth were anaesthetized with either halothane (50 patients), methoxyflurane (24 patients) or chloroform (15 patients). The activity of the uterus was registered tocodynamographically. To examine the alternate influence of narcotics and uterotonica, 57 patients were pre-medicated with sintocinon and methergin i.m. as a prophylaxis. The second group (32 patients) received no premedication to stimulate labor activity, however in 18 cases towards the end of narcosis oxytocin and methergin were given i.v. In addition to these examinations 5 vaginal deliveries were anaesthetised with halothane only. Concerning our own experimental study it can be observed: 1. The relaxative properties of halothane wich suppresses completly the activity of myometrium during the deep stages of anaesthesia are superior to chloroform and methoxyflurane. 2. More rapid relaxation of the uterus with halothane compared with chloroform and methoxyflurane. 3. After the use of halothane a quicker return of the activity of the uterus compared with chloroform and methoxyflurane. 4. The value of a prophylaxis with uterotonica can be demonstrated by a comparatively reduced slowing-down of labour-activity during anaesthesia. 5. In every one of the cases, an interuption of the labour-suppressing, caused by the anaesthesia, can be obtained by injecting intravenously oxytocin or methergin. 6. During vaginal delivery, compared to the post placentar phase, there is no need for higher concentrations of halothane to be used to suppress labour contractions. The discussion deals with the intensity of reduction of the uterus contraction caused by the above mentioned narcotics, the dangers of the atony of the uterus, and the indications and contra-indications of obstetrical anaesthesia with halothane or methoxyflurane.
D000328:Adult; D000773:Anesthesia, Obstetrical / Q000379:methods*; D002725:Chloroform / Q000494:pharmacology*; D004347:Drug Interactions; D005260:Female; D006221:Halothane / Q000494:pharmacology*; D006801:Humans; D008733:Methoxyflurane / Q000494:pharmacology*; D008755:Methylergonovine / Q000494:pharmacology; D010121:Oxytocin / Q000494:pharmacology; D014590:Uterine Contraction / Q000187:drug effects*
D008733:Methoxyflurane; D010121:Oxytocin; D002725:Chloroform; D006221:Halothane; D008755:Methylergonovine
Zur Uterotropie von Halothane, Chloroform und Methoxyflurane aus klinischer Sicht