[Peculiarities of immunological response to the administration of Vi-antigen in patients suffering from typhoid fever and in experimental animals].
Vi-antigen parenterally administered into the organism could be revealed on erythrocytes with the aid of inhibition of erythrocyte sedimentation reaction with immune Vi-serum. Patients with typhoid fever displayed positive results in 53.8% of cases. There were differences in the incidence of detection of the Vi-antigen in August and Wistar rats conditioned by theigenotype and due to the different capacity of their erythrocytes to sorb this antigen. Peculiarities of immunological response to the Vi-antigen administration depended on its sorption by erythrocytes in the organism and were the same in patients with typhoid fever and in the linear animals. A decreased capacity of erythrocyte to sorb Vi-antigen induced its more rapid elimination from the organism and caused a weak production of specific antibodies; this should be taken into consideration in immunotherapy of typhoid fever.
D000818:Animals; D000907:Antibodies, Bacterial / Q000096:biosynthesis*; D000942:Antigens, Bacterial / Q000008:administration & dosage; D004912:Erythrocytes / Q000276:immunology; D006801:Humans; D007167:Immunotherapy; D051381:Rats; D012485:Salmonella typhi / Q000276:immunology*; D014435:Typhoid Fever / Q000276:immunology* / Q000628:therapy
D000907:Antibodies, Bacterial; D000942:Antigens, Bacterial
Osobennosti immunologicheskogo otveta na vvedenie Vi-antigena u bol'nykh briushnym tifom i éksperimental'nykh zhivotnykh