Identification of four new metabolic products of metoclopramide using mass spectrometry.
1. N-(Diethylaminoethyl)-4-amino-5-chloro-2-methoxybenzamide (metoclopramide, I) N-(ethylaminoethyl)-4-amino-5-chloro-2-methoxybenzamide (II), N-(aminoethyl)-4-amino-5-chloro-2-methoxybenzamide (III), N-(2'-hydroxyethyl)-4-amino-5-chloro-2-methoxybenzamide (IV), N-(diethylaminoethyl)-4-amino-5-chloro-2-hydroxybenzamide (V) and N-(ethylaminoethyl)-4-amino-5-chloro-2-hydroxybenzamide (VI) were obtained from chloroform extracts of incubation mixtures of I or II (HCl salts) with 9000 g liver microsomal preparations from male rabbits.
D000818:Animals; D002849:Chromatography, Gas; D002851:Chromatography, High Pressure Liquid; D002855:Chromatography, Thin Layer; D008099:Liver / Q000378:metabolism; D008297:Male; D013058:Mass Spectrometry / Q000379:methods; D008787:Metoclopramide / Q000378:metabolism*; D008862:Microsomes, Liver / Q000378:metabolism*; D011817:Rabbits
D008787:Metoclopramide