A long-term effect of adult thymectomy on cortisone sensitivity and alkaline RNAse activity of murine lymphoid cells.
The alkaline RNAse content of lymphoid cells was measured in two year old mice that had been thymectomized at six to seven weeks of age and found to be three times higher in spleen and four times in lymph nodes than in sham thymectomized age-matched controls. There was, however, no difference in the content of alkaline RNAse in the liver between the two groups of mice. Following administration of cortisone, the RNAse level in the lymphoid organs was increased to a much greater extent in the control than in the thymectomized mice.
D000818:Animals; D003348:Cortisone / Q000494:pharmacology*; D008099:Liver / Q000187:drug effects / Q000201:enzymology; D008198:Lymph Nodes / Q000201:enzymology*; D008297:Male; D051379:Mice; D008808:Mice, Inbred CBA; D012260:Ribonucleases / Q000378:metabolism*; D013154:Spleen / Q000187:drug effects / Q000201:enzymology*; D013934:Thymectomy; D013950:Thymus Gland / Q000187:drug effects / Q000502:physiology*; D013997:Time Factors
D012260:Ribonucleases; D003348:Cortisone