Phosphaturia in thalassemia.
Thirteen phosphorus balances were performed in four thalassemic children aged 6 to 10 years. No correlation was found between phosphorus intake and serum level or between phosphorus intake and net absorption. There was a positive correlation among daily phosphorus intake, net absorption, and 24-hour urinary excretion. The 24-hour urinary excretion level was higher than net absorption, indicating that these children have normal phosphorus absorption but abnormally high renal phosphaturia, which leads to a deficiency of phosphorus. A strongly positive correlation was found between values for hemoglobin and serum alkaline phosphatase. In the thalassemic patients with hemoglobin levels larger than or equal to 7.5 gm/100 ml, the serum alkaline phosphatase values were larger than or equal to 15 King-Armstrong units, suggesting normal osteoblast function.
D000293:Adolescent; D000469:Alkaline Phosphatase / Q000097:blood; D002648:Child; D002675:Child, Preschool; D006454:Hemoglobins / Q000032:analysis; D006801:Humans; D010758:Phosphorus / Q000378:metabolism / Q000652:urine*; D013789:Thalassemia / Q000378:metabolism / Q000652:urine*
D006454:Hemoglobins; D010758:Phosphorus; D000469:Alkaline Phosphatase