[Effects of anticholinergics and clozapine on the activation of the striatal dopaminergic system in the rat by haloperidol. Neurochemical findings (author's transl)].
The increase in the concentration of homovanillic acid (HVA) in the haloperidol for 6 days compared to a single administration of the drug. The induction of tolerance is probably due to a functional modification of the striatal dopamine (DA)-receptors after repeated administration of the neuroleptic. Atropine given in combination with haloperidol enhances the induction of tolerance. Clozapine (20 mg/kg orally) had no such effect.
D000818:Animals; D001285:Atropine / Q000494:pharmacology*; D003024:Clozapine / Q000494:pharmacology*; D003342:Corpus Striatum / Q000378:metabolism*; D003984:Dibenzazepines / Q000494:pharmacology*; D004298:Dopamine / Q000378:metabolism*; D004357:Drug Synergism; D004361:Drug Tolerance; D006220:Haloperidol / Q000494:pharmacology*; D006719:Homovanillic Acid / Q000378:metabolism; D051381:Rats; D011955:Receptors, Drug / Q000187:drug effects
D003984:Dibenzazepines; D011955:Receptors, Drug; D001285:Atropine; D003024:Clozapine; D006220:Haloperidol; D004298:Dopamine; D006719:Homovanillic Acid
Einfluss von Anticholinergika sowie Clozapin auf die durch Haloperidol induzierte Aktivierung des dopaminergen Systems im Striatum der Ratte: Neurochemische Ergebnisse