title: Experimental bilateral deep temporal epilepsy. Effects of ablation of one focus and of different brain lesions.
abstract: In acute experiments in the rabbit, the amygdaloid nuclear complexes of the two sides were made epileptogenic through electrical stimulation or local injection of penicillin in gel. The effects on the epileptic pattern produced by surgical removal of one of the two epileptogenic amygdalae and the effects of sterotactic lesioning of the region of anterior commissure, head of caudate nucleus, and occipital cortex were analyzed. The occurrence of phenomena of both inhibitory and facilitatory interaction between the two epileptogenic amydalae was confirmed. In some experimental conditions, the restraining influence of an amygdaloid penicillin focus on the contralateral one was quite relevant, and its effect could persist even after surgical removal of the focus from which it originated. The mediation of the interamygdadoid epileptic interaction could not be ascribed to a single cerebral structure or anatomofunctionally homogenous group of structures. The phenomenon appears to involve several structures at different encephalic levels.
mesh_terms: D000679:Amygdala / Q000503:physiopathology*; D000818:Animals; D001921:Brain / Q000503:physiopathology*; D002421:Caudate Nucleus / Q000503:physiopathology; D004558:Electric Stimulation; D004564:Electrocoagulation; D004567:Electrodes, Implanted; D004569:Electroencephalography; D004833:Epilepsy, Temporal Lobe / Q000503:physiopathology*; D008032:Limbic System / Q000503:physiopathology; D009778:Occipital Lobe / Q000503:physiopathology; D009833:Olfactory Pathways / Q000503:physiopathology; D010406:Penicillins; D011817:Rabbits; D013268:Stimulation, Chemical; D013702:Temporal Lobe / Q000503:physiopathology
chemical_list: D010406:Penicillins