[(A1-beta-Alanine) insulin].
Starting from porcine insulin, A1-glycine was substituted by beta-alanine. The blood sugar lowering effect of the new analogue in the rabbit is about 45% of that of insulin. The half-maximal binding to partially purified rat liver receptors is about 46%, to transformed human lymphocytes about 54%, compared to insulin.
D000409:Alanine; D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D006801:Humans; D066298:In Vitro Techniques; D007328:Insulin / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000378:metabolism; D008099:Liver / Q000378:metabolism; D008214:Lymphocytes / Q000378:metabolism; D011485:Protein Binding; D011817:Rabbits; D051381:Rats
D001786:Blood Glucose; D007328:Insulin; D000409:Alanine
[A1-beta-Alanin]Insulin