title: Inhibition of L5178Y cells in culture by methotrexate and antibiotics.
abstract: Methotrexate, tetracycline, gentamicin, streptomycin, and penicillin inhibited the growth of L5178Y murine leukemia cells in culture with I(50) (concentration of drug that caused a 50% inhibition of growth at 72 h) values of 0.0028 mug/ml (6.2 x 10(-9) M), 7.9 mug/ml, 200 mug/ml, 1,700 mug/ml, and 3,000 mug/ml (5,000 U/ml), respectively. At concentrations achieved clinically or utilized in the laboratory, the antibiotics did not alter the I(50) of methotrexate.
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D002455:Cell Division / Q000187:drug effects; D002478:Cells, Cultured; D003864:Depression, Chemical; D007938:Leukemia / Q000503:physiopathology; D008727:Methotrexate / Q000494:pharmacology*
chemical_list: D000900:Anti-Bacterial Agents; D008727:Methotrexate