Early investigations on the effect of methyl mercuric chloride upon DMN-acute hepatotoxicity.
Acute toxicity induced by DMN was partially prevented by previously administering methyl mercuric chloride (MMC), a chemical inhibitor of the drug metabolizing enzyme system (DMES). We have studied the early changes occurring during the course of DMN-intoxication, namely disaggregation of polysomal profiles and necrosis, evaluated morphologically and by the release of S-GPT.
D000410:Alanine Transaminase / Q000097:blood; D000818:Animals; D004128:Dimethylnitrosamine / Q000378:metabolism / Q000506:poisoning / Q000633:toxicity*; D007928:Lethal Dose 50; D008099:Liver / Q000187:drug effects / Q000378:metabolism* / Q000473:pathology; D008297:Male; D008767:Methylmercury Compounds / Q000494:pharmacology*; D009602:Nitrosamines / Q000633:toxicity*; D011132:Polyribosomes / Q000187:drug effects*; D051381:Rats
D008767:Methylmercury Compounds; D009602:Nitrosamines; D000410:Alanine Transaminase; D004128:Dimethylnitrosamine