Localization of the Bf locus within the HLA region. Report on an informative family and critical evaluation of available data on Bf mapping.
Since the estimation of recombination fractions is only an arbitrary means to map genetic loci on chromosomal regions, family studies of cases with informative cross-overs within the region in question are of decisive importance. This paper reports the study of a family with a HLA-B to HLA-D cross-over which is informative in the Bf system. The possible reasons for conflicting published data on Bf gene mapping are discussed.
D002874:Chromosome Mapping; D002906:Chromosomes, Human, 6-12 and X; D003434:Crossing Over, Genetic; D006680:HLA Antigens; D006649:Histocompatibility Antigens; D006801:Humans; D011414:Properdin; D011995:Recombination, Genetic
D006680:HLA Antigens; D006649:Histocompatibility Antigens; D011414:Properdin