title: Immunogenetic aspects of nasopharyngeal carcinoma. IV. Increased risk in Chinese of nasopharyngeal carcinoma associated with a Chinese-related HLA profile (A2, Singapore 2).
abstract: The results of this study of 110 Singapore Chinese with nasopharyngeal carcinoma (NPC) and 91 controls confirmed the association between the occurrence of HLA antigen Singapore 2 (Sin2) and NPC in the Chinese population, and indicated that their increased risk for NPC was confined to the joint occurrence of Sin 2 and A2 antigens. These findings suggested that the genotype of importance in susceptibility to NPC is the A2-Sin 2 haplotype.
mesh_terms: D044466:Asian People; D005260:Female; D005838:Genotype; D006680:HLA Antigens; D006649:Histocompatibility Antigens; D006801:Humans; D008214:Lymphocytes / Q000276:immunology; D008297:Male; D009303:Nasopharyngeal Neoplasms / Q000235:genetics* / Q000276:immunology; D012306:Risk; D012846:Singapore
chemical_list: D006680:HLA Antigens; D006649:Histocompatibility Antigens