Function of myocardial mitochondria in the adriamycin-induced cardiomyopathy of rabbits.
Ultrastructural examination of the myocardia of New Zealand White rabbits showed a progressive cardiomyopathy with prominent mitochondrial lesions after 56 days of increased doses of adriamycin. During all phases of study, similar respiratory control rates and ADP:O ratios were found in myocardial mitochondria isolated from adriamycin-treated and control rabbits.
D000244:Adenosine Diphosphate / Q000378:metabolism; D000818:Animals; D003630:Daunorubicin / Q000009:adverse effects; D004305:Dose-Response Relationship, Drug; D004317:Doxorubicin / Q000008:administration & dosage / Q000009:adverse effects*; D005260:Female; D006331:Heart Diseases / Q000139:chemically induced* / Q000378:metabolism; D008297:Male; D008931:Mitochondria, Muscle / Q000187:drug effects* / Q000378:metabolism; D009206:Myocardium / Q000648:ultrastructure*; D010101:Oxygen Consumption / Q000187:drug effects; D011817:Rabbits; D013997:Time Factors
D000244:Adenosine Diphosphate; D004317:Doxorubicin; D003630:Daunorubicin