[Familial amytrophic lateral sclerosis. A study of a family suffering from this disease for three generations].
The authors describe nine cases of amytrophic lateral sclerosis running through the same family for three successive generations. The transmission is autosomal dominant with complete penetrance. The clinical picture comprises specific characteristics, amongst which the age of onset and the absence of Achilles reflexes. The course of the disease is fatal before long.
D000328:Adult; D000367:Age Factors; D000690:Amyotrophic Lateral Sclerosis / Q000235:genetics*; D005260:Female; D005799:Genes, Dominant; D006801:Humans; D008297:Male; D010375:Pedigree
Sclérose latérale amyotrophique familiale. Etude d'une famille atteinte sur trois générations