[Comparative data on the formation of complement-binding and hemagglutinating antibodies to penicillin].
Comparative data on production of complement-binding and hemagglutinating antibodies in the process of the antigenic effect of benzylpenicillin under experimental conditions are presented. 30 rabbit antisera and 3 sera of intact animals were studied. The hemagglutinating antibodies were determined in 19 antisera, high and reliable titers of the antipenicillin hemagglutinating antibodies being found only in 8 antisera. The antipenicillin complement-binding antibodies using complex antibiotic antibodies were also found in 19 antisera. The process of antibody production was more pronounced in the complement-binding reaction (CBR). Both types of the antibodies were detected simultaneously in 14 antisera. It is concluded that the CBR with the use of the penicillin complex antigenes on the stroma of the erythrocytes and in combination with the blood serum is a rather sensitive reaction for detection of antipenicillin antibodies.
D000818:Animals; D000917:Antibody Formation / Q000187:drug effects*; D000941:Antigens / Q000008:administration & dosage; D003168:Complement Fixation Tests; D006386:Hemagglutination Tests; D010400:Penicillin G / Q000276:immunology*; D011817:Rabbits; D013997:Time Factors
D000941:Antigens; D010400:Penicillin G
Sravnitel'nye dannye ob obrazovanii komplementsviazyvaiushchikh i gemaggliutiniruiushchikh antitel k penitsillinu