Ischemic therapy in thrombocytopenia from hypersplenism.
Percutaneous transfemoral arterial balloon occlusion or gelatin sponge embolization of the splenic artery or both were carried out in three high-risk patients with hepatic cirrhosis to reduce splenic hyperfunction and improve severe thrombocytopenia. Although this maneuver raised peripheral platelet counts in each patient, in one patient left upper quadrant pain with splinting of the lower chest cage led to hypostatic lower lobe pneumonia, while in another septic splentitis with gas-forming organisms necessitated splecectomy. Transfemoral occlusion of the splenic artery, although an effective, noninvasive approach to control splenic hyperfunction, has at the same time potential dangers that should be viewed with extreme caution in therapeutic application.
D000328:Adult; D000368:Aged; D001772:Blood Cell Count; D001791:Blood Platelet Disorders / Q000097:blood / Q000209:etiology / Q000628:therapy*; D001792:Blood Platelets; D002404:Catheterization; D004621:Embolization, Therapeutic / Q000009:adverse effects; D005260:Female; D006801:Humans; D006971:Hypersplenism / Q000150:complications*; D007958:Leukocyte Count; D008026:Ligation; D008297:Male; D008875:Middle Aged; D013157:Splenic Artery / Q000601:surgery