Effect of a diet with high levels of protein and fat on colon carcinogenesis in F344 rats treated with 1,2-dimethylhydrazine.
Female inbred F344 rats fed diets containing high levels of beef protein and fat or high levels of soybean protein and corn oil and treated with 1,2-dimethylhydrazine had a greater incidence of colon tumours than did rats fed diets that had normal levels of such components and were treated similarly. The source of fat and protein had no major influence on the incidence of colon tumors.
D000818:Animals; D001835:Body Weight; D003110:Colonic Neoplasms / Q000139:chemically induced / Q000209:etiology*; D004041:Dietary Fats / Q000009:adverse effects*; D004044:Dietary Proteins / Q000009:adverse effects*; D004127:Dimethylhydrazines / Q000633:toxicity*; D005260:Female; D006834:Hydrazines / Q000633:toxicity*; D008460:Meat / Q000009:adverse effects; D009821:Oils / Q000009:adverse effects; D051381:Rats; D011916:Rats, Inbred F344; D013025:Glycine max / Q000009:adverse effects; D003313:Zea mays
D004041:Dietary Fats; D004044:Dietary Proteins; D004127:Dimethylhydrazines; D006834:Hydrazines; D009821:Oils