title: Androstanediol sulphates in peripheral blood of immature rats and some of their biological effects.
abstract: The conjugation of 5alpha-androstane-3alpha,17beta-diol (3alpha-A) and its 3beta epimer (3beta-A) was determined in the peripheral blood of immature female rats. About two thirds of these steroids were present in blood as sulphates and one third as glucuronides; no free steroids were detected. Administration of 3beta-A sulphate (25mug/100 g body weight/day) and of 3alpha-A sulphate (50 mug/100 g/day) from day 21 of life until the day of vaginal opening, advanced the day of the first ovulation. Administration of the 3beta-A sulphate did not induce precocious vaginal opening whereas the free alcohol was active in this respect. Implantation of 3beta-A sulphate, but not of the 3alpha epimer, into the basal medial hypothalamus resulted in the dealth of all animals within 24 h.
mesh_terms: D015113:Androstane-3,17-diol / Q000031:analogs & derivatives / Q000097:blood* / Q000494:pharmacology; D000731:Androstanes / Q000097:blood*; D000818:Animals; D004343:Drug Implants; D005260:Female; D010060:Ovulation / Q000187:drug effects; D051381:Rats; D013997:Time Factors
chemical_list: D000731:Androstanes; D004343:Drug Implants; D015113:Androstane-3,17-diol