[Learning and chronobiological regulation following experimental damage to the coronary-artery wall of albino rats].
Forty male albino rats were used to study the relationship between experimentally (concentrated hydrochloric acid) produced local structural changes of the coronary artery wall and central nervous information processing and chronobiological events, respectively. The alterations of the coronary arteries caused by this treatment did not produce infarction but initiated on the whole length of the arterial branch proliferative processes that are complete within 12 weeks following the intervention. Central nervous information processing and chronoregulatory processes showed, immediately after exposure to hydrochloric acid, pronounced malfunctions followed by a stage of hyperreactivity (4 weeks following the damage). At 8 weeks from the intervention, the parameters of information processing and chronobiological events of the CNS again equalled the control values. Since the central nervous functions were back to normal earlier than the structural alterations, the results are interpreted as reflecting CNS-controlled interactions between the complex of visceral afference and efference, the regulation of which is determined by the CNS after coronary damage in such a way as to restore the adaptational capacity of the organism by a predominance of sanogenetic processes.
D000818:Animals; D001158:Arteries / Q000503:physiopathology; D002490:Central Nervous System / Q000503:physiopathology; D002910:Chronology as Topic; D003327:Coronary Disease / Q000503:physiopathology*; D004195:Disease Models, Animal; D007858:Learning; D008297:Male; D051381:Rats; D013997:Time Factors; D013998:Time Perception
Lernen und chronobiologische Regulation nach experimentell verursachter Schädigung der Koronararterienwand von Albinoratten