Injectable agent for the treatment of air emboli-induced paraplegia in rats.
Rats with air emboli-induced paraplegia were treated with dialy levodopa injections (intra-arterially or intraperitoneally). Of the control animals, 20% fully recovered from paraplegia during a period of 7 d. Of the levodopa treated animals, 85% fully recovered during the same period. It appears, therefore, that levodopa might be one of the few injectable agents enhancing recovery from air-induced paraplegia, suggesting its possible use in decompression sickness.
D000818:Animals; D004618:Embolism, Air / Q000150:complications*; D005260:Female; D007269:Injections, Intra-Arterial; D007274:Injections, Intraperitoneal; D007980:Levodopa / Q000008:administration & dosage / Q000627:therapeutic use*; D010264:Paraplegia / Q000188:drug therapy* / Q000209:etiology; D051381:Rats; D013997:Time Factors
D007980:Levodopa