title: Effects of D-penicillamine administration to rats, induction of renal changes: preliminary communication.
abstract: Oral administration of synthetic D-penicillamine to rats induces alterations of the renal mesangium, apparently without involvement of immune mechanisms. Alterations of mitochondria, especially enlargement, were seen in the proximal tubular epithelium. These results are discussed in the light of recent findings in "penicillamine" nephritis and diseased human kidneys in general.
mesh_terms: D000818:Animals; D004305:Dose-Response Relationship, Drug; D005921:Glomerulonephritis / Q000139:chemically induced* / Q000276:immunology / Q000473:pathology; D007074:Immunoglobulin G / Q000032:analysis; D007678:Kidney Glomerulus / Q000187:drug effects / Q000473:pathology; D008297:Male; D010396:Penicillamine / Q000008:administration & dosage / Q000009:adverse effects*; D011507:Proteinuria / Q000139:chemically induced; D051381:Rats
chemical_list: D007074:Immunoglobulin G; D010396:Penicillamine