title: Therapeutic equivalency of two lidocaine preparations.
abstract: Twenty-five volunteers were studied as to the onset and duration of action of two commercial brands of lidocaine. One and two percent concentrations of the preparations were tested intradermally using a double-blind, cross-over protocol. Both needle-drop and electrical stimulation techniques were employed as the source of pain stimulus. Five additional subjects were studied in a dose-ranging study using a placebo and lidocaine concentrations of 0.25%, 0.50%, 0.75% and 1.0%; this experiment was conduced to determine the sensitivity of the experimental methods. Both the needle-drop and electrical stimulation techniques were able to distinguish the 0.25% preparation from placebo and from the other concentrations of 1% and 2%. The two preparations were found to be statistically equivalent at concentrations of 1% and 2% and could be used interchangeably in clinical procedures.
mesh_terms: D000704:Analysis of Variance; D000779:Anesthetics, Local; D004558:Electric Stimulation; D005260:Female; D006801:Humans; D008012:Lidocaine / Q000494:pharmacology*; D008297:Male; D010919:Placebos; D013810:Therapeutic Equivalency; D013997:Time Factors
chemical_list: D000779:Anesthetics, Local; D010919:Placebos; D008012:Lidocaine