title: Changes in coagulation factors following acute myocardial infarction in man.
abstract: The whole blood clotting time, plasma fibrinogen and individual coagulation factors II, V, VII, VIII, IX, X, XI, and XII were serially measured in 14 patients over a 10-day period following acute myocardial infarction. A further six patients with similar symptoms but without evidence of myocardial infarction were also studied. The whole blood clotting time was significantly shorter within the first 24 h after infarction than on subsequent days. There were significant increases in the levels of fibrinogen and of factors VIII, IX, and XI and a significant decrease in factor XII in the patients who had sustained a myocardial infarction. The patients without myocardial infarction had no significant change in any of the coagulation factors measured.
mesh_terms: D000208:Acute Disease; D000328:Adult; D001777:Blood Coagulation; D001780:Blood Coagulation Tests; D005164:Factor IX / Q000032:analysis; D005165:Factor V / Q000032:analysis; D005167:Factor VII / Q000032:analysis; D005170:Factor X / Q000032:analysis; D005172:Factor XI / Q000032:analysis; D005174:Factor XII / Q000032:analysis; D005340:Fibrinogen / Q000378:metabolism; D006801:Humans; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000097:blood*; D011516:Prothrombin; D013997:Time Factors
chemical_list: D005165:Factor V; D005167:Factor VII; D011516:Prothrombin; D005164:Factor IX; D005170:Factor X; D005174:Factor XII; D005340:Fibrinogen; D005172:Factor XI