Inhibition of turnip yellow mosaic virus synthesis by pyrimidine analogues.
The pyrimidine analogues 2-thiouracil, 2-thiouridine, 6-azauracil and 6-azauridine all inhibited the synthesis of turnip yellow mosaic virus (TYMV) and increased the synthesis of empty virus protein shells in infected Chinese cabbage leaf discs. Uracil and uridine reversed these effects. 2-Thiouracil also reduced the UTP pool in TYMV infected leaf discs. The results are consistent with the suggestion that these analogues or their in vivo derivatives affect virus synthesis by inhibiting the biosynthesis of uridylic acid, possibly by inhibiting orotidylic acid decarboxylase.
D001380:Azauridine / Q000494:pharmacology*; D009029:Mosaic Viruses / Q000378:metabolism*; D010710:Phosphates / Q000378:metabolism; D010942:Plant Viruses / Q000378:metabolism*; D012313:RNA / Q000096:biosynthesis; D013889:Thiouracil / Q000494:pharmacology*; D013891:Thiouridine / Q000494:pharmacology*; D014498:Uracil / Q000031:analogs & derivatives* / Q000494:pharmacology*; D014500:Uracil Nucleotides / Q000096:biosynthesis; D014529:Uridine / Q000494:pharmacology; D014764:Viral Proteins / Q000096:biosynthesis; D014779:Virus Replication / Q000187:drug effects*
D010710:Phosphates; D014500:Uracil Nucleotides; D014764:Viral Proteins; D013891:Thiouridine; D014498:Uracil; D013889:Thiouracil; D012313:RNA; D001380:Azauridine; D014529:Uridine