[Atypical late onset of clinical symtoms after phenylbutazone/amidopyrine ingestion (author's transl)].
A 33 month old healthy girl accidently took 1.5 g phenylbutazone and 2.6 g aminopyrine. She was treated with gastric lavage and forced diuresis. No clinical symptoms were discovered for 17 hours after drug ingestion. She then developed generalized convulsions. After 19 hours reddish discoloration of urine was observed for first time. High serum transaminase indicated later on a toxic hepatocellular damage. It is recommended to treat patients with phenylbutazone aminopyrine insgestions for at least 24 hours even in the absence of reddish urine discoloration and clinical symptoms.
D000410:Alanine Transaminase / Q000097:blood; D000632:Aminopyrine / Q000506:poisoning*; D001219:Aspartate Aminotransferases / Q000097:blood; D002675:Child, Preschool; D004231:Diuresis; D005260:Female; D005751:Gastric Lavage; D006529:Hepatomegaly / Q000139:chemically induced; D006801:Humans; D010653:Phenylbutazone / Q000506:poisoning*; D012640:Seizures / Q000139:chemically induced; D013997:Time Factors
D000632:Aminopyrine; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase; D010653:Phenylbutazone
Ungewöhnlicher Verlauf einer Phenylbutazon-Aminophenazon-Intoxikation