title: The role of colorstrum on the occurrence of immunoglobulin G subclasses and antibody production in neonatal goats.
abstract: Quantitative determinations of IgG1 and IgG2, in one group of colostrum-fed and one group of colostrum-deprived neonatal goats revealed that the occurrence of the IgG1 subclass preceeded that of the IgG2 in both cases. In the colostrum-fed animals the IgG2 appeared, on an average, in the fourth week of life whereas in the colostrum-deprived animals the IgG2 was detected as early as three weeks after birth. At the age of twelve weeks the mean concentrations for IgG, and IgG2 were higher in the animals deprived of colostrum. The immune response to human gamma globulin was studied in colostrum-fed and colostrum-deprived neonatal goats which were immunized at birth and again after four and eight weeks. Following the first two antigen administrations a significantly higher response was obtained in the colostrum-fed neonates. However, the third injection determined a similar response in both groups. A marked suppressive effect on the immune response was observed in colostrum-fed neonatal goats when specific antibodies were present in the colostrum after preimmunization of the mothers with human gamma globulin.
mesh_terms: D000818:Animals; D000831:Animals, Newborn / Q000276:immunology*; D000917:Antibody Formation; D003126:Colostrum / Q000276:immunology*; D006041:Goats / Q000276:immunology*; D007074:Immunoglobulin G / Q000032:analysis*; D013997:Time Factors
chemical_list: D007074:Immunoglobulin G