The effect of activation of central adrenergic receptors by clonidine on the excitability of the solitary tract neurons in cats.
The effect of i.v. administered clonidine (10-15 mug/kg) on the evoked potential recorded in the dosal part of medulla oblongata, during carotid sinus nerve stimulation, was studied in chloralose-urethane anaesthetized cats. Clonidine influenced the amplitude and configuration of the evoked potential and the changes were parallel to the blood pressure depressor response. However, the blood pressure drops, evoked by i.v. infusion of papaverine, did not influence the potential. It is concluded that the synaptic transmission from the carotid sinus nerve to the second order neurons in the solatary tract area can be modulated by the clonidine-induced activation of central adrenergic receptors.
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D002346:Carotid Sinus / Q000294:innervation*; D002415:Cats; D003000:Clonidine / Q000008:administration & dosage / Q000494:pharmacology*; D004558:Electric Stimulation; D005071:Evoked Potentials; D007275:Injections, Intravenous; D008526:Medulla Oblongata / Q000187:drug effects / Q000502:physiology*; D011941:Receptors, Adrenergic; D013268:Stimulation, Chemical
D011941:Receptors, Adrenergic; D003000:Clonidine