Induction of immune responsiveness in a genetically low-responsive tumor-host combination by chemical modification of the immunogen.
Trinitrophenylated Moloney virus-induced YAC cells induced a higher cytotoxic antibody response and better protection against small tumor cell doses in syngeneic, low-responsive strain A mice than nonmodified YAC cells that had been inactivated by irradiation or mitomycin C treatment. The results indicated that genetically determined low responsiveness to a virally induced antigen can be overcome, at least to some extent, by coupling the immunizing cells to a strong immunogenic hapten.
D000818:Animals; D000917:Antibody Formation; D000951:Antigens, Neoplasm; D005796:Genes; D006241:Haptens; D008214:Lymphocytes / Q000276:immunology; D008223:Lymphoma / Q000276:immunology*; D051379:Mice; D008815:Mice, Inbred Strains; D008979:Moloney murine leukemia virus; D009374:Neoplasms, Experimental / Q000276:immunology; D009578:Nitrobenzenes / Q000276:immunology*; D014301:Trinitrobenzenes / Q000276:immunology*
D000951:Antigens, Neoplasm; D006241:Haptens; D009578:Nitrobenzenes; D014301:Trinitrobenzenes