A case of male pseudohermaphroditism associated with elevated LH, normal FSH and low testosterone possibly due to the secretion of an abnormal LH molecule.
A 27 year old female is described who had 46,XY chromosome complement, ambiguous external genitalia with elevated LH, slightly above normal FSH and low testosterone. Her plasma testosterone level increased 15-20 fold after HCG stimulation (5000 IU X 3). then returned to prestimulation level 3 months later. This was possibly due to the secretion of an abnormal LH molecule which is immunoreactive but biologically inactive in the human.
D000328:Adult; D001485:Basement Membrane / Q000473:pathology; D012734:Disorders of Sex Development / Q000097:blood / Q000473:pathology / Q000503:physiopathology*; D005260:Female; D005640:Follicle Stimulating Hormone / Q000097:blood / Q000378:metabolism*; D006801:Humans; D007986:Luteinizing Hormone / Q000097:blood / Q000378:metabolism*; D008297:Male; D010902:Pituitary Gland / Q000503:physiopathology*; D010903:Pituitary Gland, Anterior / Q000378:metabolism / Q000503:physiopathology*; D013737:Testis / Q000473:pathology; D013739:Testosterone / Q000097:blood / Q000378:metabolism*
D013739:Testosterone; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone