The effect of 6-aminodopamine on electrical self-stimulation in rats.
The compound 6-aminodopamine is a powerful CNS catecholaminergic neurotoxin. Small dosages of 6-aminodopamine injected intraventricularly markedly depress electrical self-stimulation rates in rats. This 6-aminodopamine treatment produced whole brain lowering of norepinephrine to ca. 50% of normal while the dopamine content was unchanged. The possible use of 6-aminodopamine treatment to elucidate the relative roles of norepinephrine and dopamine pathways is discussed.
D000818:Animals; D001921:Brain / Q000378:metabolism; D003864:Depression, Chemical; D004298:Dopamine / Q000031:analogs & derivatives* / Q000378:metabolism / Q000494:pharmacology; D004558:Electric Stimulation; D008297:Male; D009638:Norepinephrine / Q000378:metabolism; D051381:Rats; D012653:Self Stimulation / Q000187:drug effects*
D004298:Dopamine; D009638:Norepinephrine