[Experience with combined use of neurolepsy and vasodilator substances in the treatment of patients with acute myocardial infarct].
On the basis of an examination of 412 patients with myocardial infarction the efficacy of a long-term employment (for 3--4 days) of a neuroleptic Droperidol and a vasodilator Curantyl was examined. Optimum dosages of the drug and its administration techniques were worked out with due account of the data of clinical and physiological observations and blood concentrations of Curantyl. The incidence of the pain syndrome, of extrasystolic arrhythmias, of cardiogenic shock and sudden ventricular fibrillation was shown to decrease under the effect of the treatment. Without affecting the haemodynamics of the general circulation, the employed combination of drugs improved the pulmonary circulation and produced a beneficial inotropic effect upon the right ventricular myocardium, thus causing a distinct improvement of microcirculation, normalizing the ratio of diameters of the arterioles and venules, increasing the level of the tissue blood flow, and significantly reducing the intravascular aggregation of the formed elements of the blood. A long-term combined employment of the drugs for a few early days of the disease clearly favoured a positive haemodynamics in an important part of the patients, as demonstrated by the data of electro- and vectorcardiography.
D000208:Acute Disease; D000328:Adult; D000368:Aged; D001145:Arrhythmias, Cardiac / Q000517:prevention & control; D001794:Blood Pressure; D002302:Cardiac Output; D004176:Dipyridamole / Q000008:administration & dosage / Q000627:therapeutic use*; D004329:Droperidol / Q000008:administration & dosage / Q000627:therapeutic use*; D004359:Drug Therapy, Combination; D006321:Heart / Q000503:physiopathology; D006439:Hemodynamics; D006801:Humans; D008297:Male; D008833:Microcirculation; D008875:Middle Aged; D009200:Myocardial Contraction; D009203:Myocardial Infarction / Q000188:drug therapy* / Q000503:physiopathology; D010146:Pain / Q000517:prevention & control; D012770:Shock, Cardiogenic / Q000517:prevention & control; D014672:Vectorcardiography; D014693:Ventricular Fibrillation / Q000517:prevention & control
D004176:Dipyridamole; D004329:Droperidol
Opyt sovmestnogo ispol'zovaniia dlitel'noĭ neĭrolepsii i vazodilatatornykh sredstv pri lechenii bol'nykh ostrym infarktom miokarda