[Transplacental and immediate effect of ortho-aminoazotoluol on organ cultures of embryonal mouse liver].
A study was made of the transplacental and direct action of orthoaminoazotoluol (OAAT) in the organ cultures of the embryonic liver of mice of a highly hepatomic CBA line. In direct action in vitro OAAT caused a marked reduction of survival of the organ cultures of the embryonic liver in comparison with control. In the transplacental action of OAAT the toxic effect was replaced at the last periods of cultivation by the growth stimulating one; the percentage of live experimental cultures increased by 30 in comparison with control.
D000818:Animals; D001391:Azo Compounds / Q000633:toxicity*; D056486:Chemical and Drug Induced Liver Injury; D005260:Female; D008107:Liver Diseases / Q000196:embryology; D008431:Maternal-Fetal Exchange; D051379:Mice; D008808:Mice, Inbred CBA; D009924:Organ Culture Techniques; D011247:Pregnancy; D009762:o-Aminoazotoluene / Q000633:toxicity*
D001391:Azo Compounds; D009762:o-Aminoazotoluene
Transplatsentarnoe i neposredstvennoe deĭstvie ortoaminoazotoluola na organnye kul'tury émbrional'noĭ pecheni mysheĭ