Metabolism of testosterone 4-14C in skin of castrated rats.
Testosterone metabolism was studied in the skin and preputial glands of normal and prepuberally castrated male rats during the 2nd hair cycle. In catagen-telogen the 17-beta-OHSDH of dorsal skin was higher in castrated than in control animals; 5-alpha-reductase instead, remained unchanged through out the hair cycle. Also in the preputial glands of castrated rats 17-beta-OHSDH was higher than in normal rats. So was 5-alpha-reductase. A possible direct control of a substrate, like Testosterone, and/or of a hypophyseal tropin, like prolactin, on enzymes that direct the metabolism of steroids in target tissues is conceivable.
D013741:3-Oxo-5-alpha-Steroid 4-Dehydrogenase / Q000032:analysis; D000818:Animals; D002369:Castration; D004960:Estradiol Dehydrogenases / Q000032:analysis; D006197:Hair / Q000254:growth & development; D008297:Male; D010413:Penis; D010507:Periodicity; D051381:Rats; D012627:Sebaceous Glands / Q000378:metabolism; D012867:Skin / Q000378:metabolism*; D013739:Testosterone / Q000378:metabolism*
D013739:Testosterone; D004960:Estradiol Dehydrogenases; D013741:3-Oxo-5-alpha-Steroid 4-Dehydrogenase