[Participation of the lungs in the formation of an immune response].
The process of accumulation of the antibody-forming cells (AFC) in the lungs after vaccination of rabbits with the typhoid antigen was studied. No AFC was revealed in the lungs after single aerosol and subcutaneous immunization; double administration of the antigen through the respiratory tracts was followed by significant AFC accumulation in the lung tissue; individual antibody-synthesizing cells were found in the lung after subcutaneous application. Revaccination was followed by intensification of the immune response of the lung in both methods of vaccination; the content of antibody-producing cells in the aerosol-immunized rabbits was much greater than in the animals vaccinated subcutaneously. This indicated a definite role of the lungs in the immunogenesis in the case of the antigen administration through the respiratory tract.
D000818:Animals; D000917:Antibody Formation; D000921:Antibody-Producing Cells / Q000276:immunology; D000942:Antigens, Bacterial / Q000008:administration & dosage; D002452:Cell Count; D007114:Immunization; D007117:Immunization, Secondary; D008168:Lung / Q000276:immunology*; D011817:Rabbits; D012485:Salmonella typhi / Q000276:immunology; D013997:Time Factors; D014436:Typhoid-Paratyphoid Vaccines / Q000008:administration & dosage; D014611:Vaccination
D000942:Antigens, Bacterial; D014436:Typhoid-Paratyphoid Vaccines
Uchastie legkikh v formirovanii immunogo otveta