General derivation of the ideal intravenous drug input required to achieve and maintain a constant plasma drug concentration. Theoretical application to lignocaine therapy.
A constant plasma drug concentration can be achieved and maintained by the intravenous administration of an initial bolus loading dose in conjunction with a constant rate and an exponential intravenous drug infusion. The drug input required to achieve a constant plasma drug concentration is derived without making any assumptions about the nature of drug distribution within the body or elimination from the body.
D007263:Infusions, Parenteral; D007275:Injections, Intravenous; D007700:Kinetics; D008012:Lidocaine / Q000008:administration & dosage / Q000097:blood*; D008433:Mathematics; D004364:Pharmaceutical Preparations / Q000008:administration & dosage / Q000097:blood*; D013997:Time Factors
D004364:Pharmaceutical Preparations; D008012:Lidocaine