title: [Carcinogenicity of fuchsin derivatives].
abstract: White noninbred rats and linear mice were injected leucoparafuchsine and leucofuchsine isomers subcutaneously and received perorally during the whole life period, while in the experiments on mice--also by means of cutaneous application. The injection of leucoparafuchsine in rats and mice CC57Br resulted in the increased development of hemopoietic system tumors. Leucofuchsine isomers injected in rats and mice C3HA gave rise to the appearance of renal tumors in these animals and caused more frequent development of hepatic and pulmonary neoplasms in mice. In leucoparafuchsine injections the rate of tumors incidence was 35% in rats and in mice--20%, in the experiments with leucofuchsine isomers--33% and 40% accordingly. The results of the experiments evidence an insignificant blastomogenic effect of the compounds under study.
mesh_terms: D000232:Adenofibroma / Q000139:chemically induced; D000284:Administration, Oral; D000287:Administration, Topical; D000818:Animals; D002273:Carcinogens; D007279:Injections, Subcutaneous; D007680:Kidney Neoplasms / Q000139:chemically induced; D008113:Liver Neoplasms / Q000139:chemically induced; D008175:Lung Neoplasms / Q000139:chemically induced; D008325:Mammary Neoplasms, Experimental / Q000139:chemically induced; D051379:Mice; D009374:Neoplasms, Experimental / Q000139:chemically induced*; D051381:Rats; D012394:Rosaniline Dyes / Q000031:analogs & derivatives* / Q000633:toxicity; D013045:Species Specificity
chemical_list: D002273:Carcinogens; D012394:Rosaniline Dyes
vernacular_title: O kantserogennosti proizvodnykh fuksina