title: Klinefelter's syndrome: experiences with 24 patients.
abstract: Twenty-four karotypically proven patients with Klinefelter's syndrome were studied. The majority suffered from disorders of personality and social adjustment. All were poorly educated. Two-thirds showed gynaecomastia and all had small testes. Eunuchoid body proportions were seen in the majority of patients. Half the patients had plasma androgen levels in the low normal range; in the rest the levels were subnormal. The serum LH level was elevated in 80% and could not be adequately suppressed by exogenous androgens in seven out of nine patients. Abnormalities of carbohydrate metabolism were demonstrated in seven patients. Bilateral mastectomy was a valuable form of therapy, but androgens were withheld for phychosocial reasons.
mesh_terms: D000293:Adolescent; D000328:Adult; D000728:Androgens / Q000097:blood; D001786:Blood Glucose / Q000378:metabolism; D005191:Family Characteristics; D005640:Follicle Stimulating Hormone / Q000097:blood; D006801:Humans; D007360:Intelligence; D007713:Klinefelter Syndrome / Q000097:blood / Q000473:pathology; D007986:Luteinizing Hormone / Q000097:blood; D008297:Male; D008875:Middle Aged; D013737:Testis / Q000473:pathology; D013739:Testosterone
chemical_list: D000728:Androgens; D001786:Blood Glucose; D013739:Testosterone; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone