title: [Effect of nitrosomethylurea and 1,4-bis-diazoacetylbutane on alkaline ribonuclease activity].
abstract: It was shown that at 37 degrees C nitrosomethylurea causes an 8-fold increase (as compared to the normal) of the activity of alkaline ribonuclease. 1,4-Bis-diazoacetylbutane also activated alkaline ribonuclease at 37 degrees C. A dependence of the effect of chemical mutagens studied on the activity of alkaline ribonuclease on their concentration was observed. The activation of ribonuclease by NMU and DAB affords a possibility to understand the molecular mechanisms of the action of chemical mutagens on the metabolism.
mesh_terms: D001391:Azo Compounds; D002384:Catalysis; D004789:Enzyme Activation; D008770:Methylnitrosourea; D009607:Nitrosourea Compounds; D012260:Ribonucleases; D013696:Temperature
chemical_list: D001391:Azo Compounds; D009607:Nitrosourea Compounds; D008770:Methylnitrosourea; D012260:Ribonucleases
vernacular_title: Vliianie nitrozometilmocheviny i 1,4-bis-diazoatsetilbutana na aktivost' shchelochnoĭ ribonukleazy