[Behavior of various metabolites of carbohydrate metabolism in the liver of young pigs following inhibition of C-11 hydroxylase and adrenalectomy].
The effects of glucocorticoid depression by C-11 hydroxylase inhibition and total adrenalectomy upon certain metabolites of the plasma, liver, and muscles that are related to gluconeogenesis were studied on ten store pigs. Metopiron caused decline of glucose and pyruvate concentrations in plasma and drop of liver glycogen. Total adrenalectomy caused changes of the same kind but much stronger in the agonal phase, yet without rendering the animals hypoglycaemic. Muscular glycogen dropped to one third of the normal. The results are discussed with reference to earlier studies into store pig.
D000315:Adrenalectomy; D000818:Animals; D050260:Carbohydrate Metabolism; D005943:Gluconeogenesis / Q000187:drug effects; D008099:Liver / Q000201:enzymology*; D008797:Metyrapone / Q000494:pharmacology; D006899:Mixed Function Oxygenases / Q000037:antagonists & inhibitors*; D009132:Muscles / Q000201:enzymology; D013552:Swine / Q000378:metabolism*
D006899:Mixed Function Oxygenases; D008797:Metyrapone
Das Verhalten einiger Metabolite des Kohlenhydratstoffwechsels in der Leber von Läuferschweinen nach C-11 Hydroxylase-Nemmung und Adrenalektomie