title: Stimulation and inhibition of renal PG biosynthesis: effects on renal blood flow and on plasma renin activity.
abstract: In the present investigation prostaglandins (PGs) were determined in the renal cortex and the functional effects of the renal PGs on renal hemodynamics and on the renin-angiotensin system were evaluated. The levels of PGs, determined by mass fragmentography, were in the medulla: PGE2 4.36 +/- 1.04 mug/g and PGF2 alpha 1.6 +/- 0.50 mug/g and in the cortex: PGE2 0.19 +/- 0.04 mug/g and PGF2 alpha 0.21 +/- 0.07 mug/g. The unequivocal demonstration of PGs in the renal cortex forms a biochemical basis for a role of PGs in the regulation of renal hemodynamics and of the renin-angiotensin system.
mesh_terms: D000804:Angiotensin II / Q000097:blood; D000818:Animals; D007213:Indomethacin / Q000494:pharmacology; D007672:Kidney Cortex / Q000378:metabolism*; D007679:Kidney Medulla / Q000378:metabolism; D011448:Prostaglandin Antagonists / Q000378:metabolism*; D011453:Prostaglandins / Q000096:biosynthesis*; D011817:Rabbits; D012039:Regional Blood Flow / Q000187:drug effects; D012083:Renin / Q000097:blood*
chemical_list: D011448:Prostaglandin Antagonists; D011453:Prostaglandins; D000804:Angiotensin II; D012083:Renin; D007213:Indomethacin