Effects of serine on morphine-dependent mice.
Single doses of serine (250 mg/kg i.p.) failed to elevate central glycine in mice (1 h after injection), or to compensate for losses caused by implantation of morphine base (70 mg/animal), and reduced the jumping response to nalorphine (100 mg/kg i.p.). In contrast, sustained treatment with 250-mg/kg doses of serine at 24-hour intervals produced increases in brain and medullar glycine (1 h after 4th injection: 46-50% in normal, 39-75% in morphine-dependent mice, and enhanced the jumping response (40% over controls).
D000818:Animals; D001921:Brain / Q000378:metabolism*; D004361:Drug Tolerance; D005998:Glycine / Q000378:metabolism*; D006801:Humans; D008297:Male; D051379:Mice; D009021:Morphine Dependence / Q000378:metabolism*; D009269:Nalorphine / Q000494:pharmacology; D012694:Serine / Q000494:pharmacology*; D013331:Strychnine / Q000633:toxicity; D013375:Substance Withdrawal Syndrome
D012694:Serine; D013331:Strychnine; D005998:Glycine; D009269:Nalorphine