[A novel method for measurement of cerebral blood flow in the animal experiment].
A method is described for the measurement of cerebral blood flow by coutinuous registration of the venous out-flow from the temporal sinus of anaesthetized dogs. This method can be used advantageously for the screening of unknown compounds because samples of "cerebral" venous blood are obtained by a less complicated and reliable technique. Changes in cerebral blood flow induced with well defined substances, were registered with our method. The results are discussed.
D000241:Adenosine / Q000494:pharmacology; D000818:Animals; D002560:Cerebrovascular Circulation / Q000187:drug effects; D003911:Dextrans / Q000494:pharmacology; D004285:Dogs; D004353:Drug Evaluation, Preclinical / Q000379:methods; D008722:Methods; D008991:Monitoring, Physiologic; D009638:Norepinephrine / Q000494:pharmacology; D010208:Papaverine / Q000494:pharmacology
D003911:Dextrans; D010208:Papaverine; D000241:Adenosine; D009638:Norepinephrine
Eine methodische Alternative zur Messung der Gehirndurchlutung im Tierexperiment