[Teratogenic and embryotoxic activity of several 2,4-diaminopyrimidine derivatives].
The degree of teratogenic and embryotoxic effects is dependent not only on the period of gestation and the agent dosage but also on the chemical structure of its molecule. In the series of derivatives of 2,4-diamino-5-phenylpyrimidine with different length of the alkul radical in the 6 position the preparation with ethyl group has the greatest injuring effect. Thus, the structural distinctions in the molecules of pharmacological agents are responsible for the selective toxicity of drugs in relation to mammalian embryos.
D000014:Abnormalities, Drug-Induced / Q000473:pathology*; D000818:Animals; D004305:Dose-Response Relationship, Drug; D005260:Female; D005313:Fetal Death / Q000139:chemically induced; D011247:Pregnancy; D011743:Pyrimidines / Q000633:toxicity*; D051381:Rats; D013723:Teratogens
D011743:Pyrimidines; D013723:Teratogens
Teratogennaia i émbriotoksicheskaia aktivnost' nekotorykh proizvodnykh 2,4-diaminopirimidina