Gamma-aminobutyric acid: selective inhibition of electrically induced head-turning following intracaudate administration.
GABA selectively antagonized head-turning elicited by electrical stimulation of the caudate nucleus in the rat when applied directly to the site of stimulation utilizing an electrode-cannula. Pretreatment with picrotoxin, a GABA antagonist, prevented the action of GABA on the head-turn response. This report provides in vivo evidence that GABA may play an inhibitory role in basal ganglia function. The findings are relevant to basal ganglia disorders in man.
D000613:Aminobutyrates / Q000494:pharmacology*; D000818:Animals; D001479:Basal Ganglia / Q000187:drug effects; D001519:Behavior / Q000187:drug effects*; D002421:Caudate Nucleus / Q000502:physiology; D004558:Electric Stimulation; D006801:Humans; D007267:Injections; D008297:Male; D010852:Picrotoxin / Q000494:pharmacology; D051381:Rats; D013239:Stereotyped Behavior / Q000187:drug effects*; D013997:Time Factors; D005680:gamma-Aminobutyric Acid / Q000008:administration & dosage / Q000494:pharmacology*
D000613:Aminobutyrates; D010852:Picrotoxin; D005680:gamma-Aminobutyric Acid