Cytotoxic effector capacity of bone marrow mononuclear cells.
Purified mononuclear cells from guinea pig bone marrow possess highly efficient cytotoxic effector cell capabilities in the phytohemagglutinin-induced cellular cytotoxity and antibody-dependent cellular cytotoxicity and antibody-dependent cellular cytotoxicity assays against chicken red blood cell targets. This cytotoxic activity is not removed by depletion of adherent cells by passage through rayon wool columns. Thus bone marrow lymphocytes themselves, depleted of adherent monocytes, possess this killer cell capacity. These effector cells may either arise de novo within the bone marrow parenchyma or arrive there as part of the recirculating lymphocyte pool. These studies lend further understanding of the development of functional capabilities of bone marrow lymphoid cells.
D000818:Animals; D000918:Antibody Specificity; D001853:Bone Marrow / Q000276:immunology*; D001854:Bone Marrow Cells; D002448:Cell Adhesion; D003601:Cytotoxicity Tests, Immunologic; D004306:Dose-Response Relationship, Immunologic; D006168:Guinea Pigs; D037102:Lectins / Q000494:pharmacology; D008214:Lymphocytes / Q000276:immunology*
D037102:Lectins