title: [Morphological study of 2 cases of congenital toxoplasmosis].
abstract: A morphological study of two cases of acute generalized congenital toxoplasmosis has shown that in one case the most heavily involved organ was the heart (focal necrotic myocarditis), in addition to some changes in the central nervous system (leptomeningitis), and in the other case, the most affected organ was the cerebrum (focal necrotic encephalitis). In both cases, in almost all organs, there were degenerative and reactive changes. Toxoplasma was found in necrotic foci of the myocardium and the brain. Some basic views concerning a special vulnerability of the central nervous system in toxoplasmosis are put forward. The basic fact is that the explanation for the infection of exposed fetuses lies in the condition of the immune system (in the degree of its development and activity), especially regarding certain localizations of changes in the organs with a less developed activity of the local immune system.
mesh_terms: D001344:Autopsy; D004660:Encephalitis / Q000382:microbiology; D006801:Humans; D007231:Infant, Newborn; D008297:Male; D009205:Myocarditis / Q000382:microbiology; D009336:Necrosis; D014122:Toxoplasma / Q000302:isolation & purification; D014125:Toxoplasmosis, Congenital / Q000473:pathology*
vernacular_title: Morfoloska studija dva slucaja kongenitalne toksoplazmoze