title: Analysis of baby hamster kidney cells persistently infected with lymphocytic choriomeningitis virus.
abstract: Baby hamster kidney cells were persistently infected with lymphocytic choriomeningitis (LCM) virus (BHKpi cells). After 21 passages of the BHKpi cells infectious virus could no longer be detected; however, the cultures continued to produce LCM virus particles which interfered with the replication of infectious LCM virus in BHKpi cells and protected mice from a subsequent intracranial inoculation of infectious LCM virus. Cultures of BHKpi cells appeared to consist of three cell populations: uninfected cells, infected cells containing infectious LCM virus, and infected cells releasing interfering particles of LCM virus.
mesh_terms: D000818:Animals; D000956:Antigens, Viral / Q000032:analysis; D002460:Cell Line; D006224:Cricetinae; D008217:Lymphocytic choriomeningitis virus / Q000254:growth & development* / Q000276:immunology / Q000302:isolation & purification; D014762:Viral Interference; D014779:Virus Replication
chemical_list: D000956:Antigens, Viral