Tissue distribution of bovine 125I-superoxide dismutase in mice.
Intravenously injected 125I-bovine superoxide dismutase in mice is essentially cleared from organs in 24 h. The 125I activity per g of tissue at 1 h varies among organs with the brain and kidneys showing the lowest and highest levels, respectively. Within tissues, degradation occurs so that, at 1 h after administration, 5-74% of the 125I activity remains associated with the enzyme, depending on the tissue. A small amount of the labelled enzyme is found in washed cells of thymus, lung, spleen, liver and brain.
D000818:Animals; D002477:Cells / Q000201:enzymology; D005260:Female; D051379:Mice; D013482:Superoxide Dismutase / Q000378:metabolism*; D013997:Time Factors
D013482:Superoxide Dismutase