title: The prognosis in acromegaly treated by transanthro-sphenoidal operation.
abstract: The paper is a report of a follow-up study of 80 acromegalic patients treated by transanthro-sphenoidal removal of a pituitary adenoma. The average follow-up time was 3.7 years. Complete restitution or improvement of the visual field defects was noted in 77%. Total regression of the soft tissue swelling was observed in around 1/3 of the patients. Complete regression or improvement of the acromegalic activity was achieved in 94%. Total regression of the dominant symptoms was noted in 74%. The rate of tumour recurrence was around 5% and the total mortality rate in the disease during the follow-up period 7.5%. The transanthro-sphenoidal surgery of the pituitary adenoma in this series resulted in a high rate of regression of the acromegalic symptoms at the same time as normal anterior pituitary function often was restored.
mesh_terms: D000172:Acromegaly / Q000401:mortality / Q000601:surgery*; D000236:Adenoma / Q000601:surgery*; D000293:Adolescent; D000328:Adult; D000368:Aged; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local; D010911:Pituitary Neoplasms / Q000601:surgery*; D011183:Postoperative Complications; D011379:Prognosis; D013100:Sphenoid Bone / Q000601:surgery