Adenocarcinoma-associated antigen: enhancement of tumor growth with serum from animals bearing adenocarcinoma.
Why do tumors continue to grow in the presence of cell-mediated immune reactions? When inoculated subcutaneously, 10(5) viable spontaneous mammary adenocarcinoma cells produced solid tumors that progressively proliferated and eventually killed all the recipient mice. During the first 10 days after inoculation, the mice developed antibody titers, and the serum acquired toxic activity against the tumor cells. As the tumor gained in size these two activities ceased. Serum of normal mice had no effect on the tumor; the serum of mice immunized with an adenocarcinoma-associated antigen (a glycoprotein) inhibited growth, but that of mice with progressive tumors enhanced proliferation of the tumors.
D000230:Adenocarcinoma / Q000276:immunology* / Q000473:pathology; D000818:Animals; D000951:Antigens, Neoplasm; D001943:Breast Neoplasms / Q000276:immunology*; D002471:Cell Transformation, Neoplastic; D005260:Female; D006168:Guinea Pigs; D007111:Immunity, Cellular; D051379:Mice
D000951:Antigens, Neoplasm