Synthesis and preliminary antimicrobial screening of two thiosulfonates.
Tetramethylene bis(methanethiosulfonate), the S-ester analog of busulfan, was prepared by reacting 1,4-dibromobutane with potassium methanethiosulfonate. 2,4-Dichlorophenyl methanethiosulfonate was prepared by reacting sodium methanesulfinate with 2,4-dichlorobenzenesulfenyl chloride. Neither compound showed antifungal activity against Microsporum audouini or Trichophyton mentagrophytes. Although tetramethylene bis(methanethiosulfonate) was more active against Staphylococcus aureus than was 2,4-dichlorophenyl methanethiosulfonate, neither compound was as active as the streptomycin control.
D000890:Anti-Infective Agents / Q000138:chemical synthesis*; D000935:Antifungal Agents / Q000138:chemical synthesis; D008722:Methods; D008826:Microbial Sensitivity Tests; D013451:Sulfonic Acids / Q000138:chemical synthesis*; D013886:Thiosulfonic Acids / Q000138:chemical synthesis* / Q000494:pharmacology
D000890:Anti-Infective Agents; D000935:Antifungal Agents; D013451:Sulfonic Acids; D013886:Thiosulfonic Acids