Changes in fecal composition and colonic function due to cereal fiber.
The effect on colonic function of adding wheat fiber for 3 weeks to the metabolically-controlled diets of six healthy volunteers has been studied. Increasing dietary fiber intake from 17 to 45 g/day increased fecal weight from 79 +/- 6.6 g/day to 228 +/- 29.9 g/day and shortened mean transit time, measured by a continuous marker method, from 57.8 +/- 8.3 hr to 40.3 +/- 8.9 hr. The increase in fecal weight was largely due to water. Fiber caused a dilution of fecal marker and an increase in fecal fat, nitrogen, and calcium output. Fecal sodium, potassium, and chloride showed only small changes but volatile fatty acid output increased significantly without concentrations changing. Fecal bile acid output increased from 199 +/- 46 mg/day to 279 +/- 46 mg/day. These changes are discussed in light of current views of the role of dietary fiber in protecting against colon cancer.
D000328:Adult; D001647:Bile Acids and Salts / Q000032:analysis; D002118:Calcium / Q000032:analysis; D002482:Cellulose / Q000627:therapeutic use; D003106:Colon / Q000502:physiology*; D003110:Colonic Neoplasms / Q000517:prevention & control; D004043:Dietary Fiber / Q000627:therapeutic use; D005227:Fatty Acids / Q000032:analysis; D005243:Feces / Q000032:analysis*; D005769:Gastrointestinal Motility; D006801:Humans; D008274:Magnesium / Q000032:analysis; D008297:Male; D009584:Nitrogen / Q000032:analysis; D010758:Phosphorus / Q000032:analysis; D014908:Triticum
D001647:Bile Acids and Salts; D004043:Dietary Fiber; D005227:Fatty Acids; D010758:Phosphorus; D002482:Cellulose; D008274:Magnesium; D009584:Nitrogen; D002118:Calcium