Prenatal and postnatal toxicity induced in guinea-pigs by nitrosomethylurea.
Oral administration of NMU at maximally tolerated doses of guinea-pigs from day 34 to 58 of pregnancy induced embryotoxic effects, as evidenced by a high incidence of stillbirths and reduction in birth weight, and postnatal toxic effects, as evidenced by stunting, progressive mortality and extensive fatty degeneration of the liver in F1 progeny. Similar administration of NMUT at maximally tolerated doses did not induce such toxic effects.
D000818:Animals; D000831:Animals, Newborn; D005234:Fatty Liver / Q000139:chemically induced; D005260:Female; D005313:Fetal Death / Q000139:chemically induced*; D006168:Guinea Pigs; D008098:Litter Size / Q000187:drug effects; D008770:Methylnitrosourea / Q000633:toxicity*; D009605:Nitrosomethylurethane / Q000633:toxicity*; D009607:Nitrosourea Compounds / Q000633:toxicity*; D011018:Pneumonia, Pneumococcal / Q000139:chemically induced; D011247:Pregnancy; D014520:Urethane / Q000031:analogs & derivatives*
D009607:Nitrosourea Compounds; D014520:Urethane; D009605:Nitrosomethylurethane; D008770:Methylnitrosourea