Cell-mediated autoimmunity in coeliac disease.
Lymphocyte transformation in response to a crude freeze-dried prepartion of whole jejunal mucosa was studied in fifteen patients with coeliac disease and compared with the findings in fifteen age-matched controls. The transformation ratio was markedly increased in three patients. These observations suggest the possible existence of cell-mediated autoimmunity to jejunal mucosa in some patients with coeliac disease and might be relevant to the development of some of the complications of the disease.
D000293:Adolescent; D000328:Adult; D001327:Autoimmune Diseases; D002446:Celiac Disease / Q000209:etiology / Q000276:immunology*; D005260:Female; D006801:Humans; D007111:Immunity, Cellular; D007413:Intestinal Mucosa / Q000276:immunology; D007583:Jejunum / Q000276:immunology; D008213:Lymphocyte Activation; D008297:Male; D008875:Middle Aged; D014374:Tuberculin Test