Carcinoembryonic antigen (CEA) assays in obstructive colorectal cancer.
Four of 40 patients with resectable colon or rectal cancer had tumors causing acute large bowel obstruction with colonic dilatation; all 4 patients had preoperative CEA titers above 10 ng/ml with a mean of 28 ng/ml. Thirty-six cancer patients without acute colon obstruction had a mean CEA titer of 4.5 ng/ml; only 6 of 36 patients had circulating CEA titers 10 ng/ml or greater. This suggested that pre-treatment CEA titers in patients with obstructing cancer are unusually high. Multiple CEA assays were performed on two of the 4 patients with colonic obstruction before and after bowel decompressive procedures and prior to their definitive treatment. Relief of obstruction alone produces marked reduction in circulating CEA; this suggested that not only the extent of disease but also the pathophysiological changes associated with obstruction influenced circulating CEA levels.
D002272:Carcinoembryonic Antigen / Q000032:analysis*; D003082:Colectomy; D003110:Colonic Neoplasms / Q000276:immunology* / Q000601:surgery; D003125:Colostomy; D005260:Female; D006801:Humans; D007415:Intestinal Obstruction / Q000276:immunology* / Q000601:surgery; D008875:Middle Aged; D012004:Rectal Neoplasms / Q000276:immunology*
D002272:Carcinoembryonic Antigen