Codominant inheritance in immunogenetic (IR-gene) systems.
Immunogenetic (IR-gene) systems consist of animals showing different quantitative antibody responses when immunized with similar doses of a given antigen. Strains of animals giving high and low antibody titres are described as high and low responders, respectively. The degree of dominance in F1 hybrid strains, obtained from a cross between high and low responder parents, can readily be calculated using the dominance index formula, which takes the value of +1 for complete dominance, -1 for complete recessivity and the value of zero for no dominance. In reviewing 1527 F1 animals, obtained from ninety-one immunogenetic systems, the degree of diminance (d) was found to be: +0-0076 +/- 0-1053 (mean +/- s.e.), which is close to a value of zero and this is consistent with codominant inheritance. It is suggested that in immunogenetic systems, both alleles are expressed as codominant genes.
D000818:Animals; D000906:Antibodies / Q000032:analysis; D000917:Antibody Formation; D005799:Genes, Dominant; D006168:Guinea Pigs; D006824:Hybridization, Genetic; D051379:Mice; D051381:Rats
D000906:Antibodies