[Experimental comparative study on the antiepileptic effect of clonazepam, sodium dintoine and phenobarbital administered parenterally].
A comparative study of the antiepileptic action of Clonazepam, phenythoin-natrium and phenobarbital has been performed in acute experiments in rabbits. The effort of the three drugs, administered intravenously, was studied on a) the epileptic activity induced by electrical stimulation of the amygdala, b) the interictal and c) ictal epileptic activity of an amygdaloid chemical focus (penicillin in gel). Clonazepam has a definite higher capacity, than the other drugs examined to prevent or to reduce the phenomenon of generalization of epilepsy. However, its effect has a shorter duration.
D000818:Animals; D001570:Benzodiazepinones / Q000008:administration & dosage*; D002998:Clonazepam / Q000008:administration & dosage* / Q000627:therapeutic use; D005260:Female; D007275:Injections, Intravenous; D008297:Male; D010634:Phenobarbital / Q000008:administration & dosage* / Q000627:therapeutic use; D010672:Phenytoin / Q000008:administration & dosage* / Q000627:therapeutic use; D011817:Rabbits; D012640:Seizures / Q000188:drug therapy*
D001570:Benzodiazepinones; D002998:Clonazepam; D010672:Phenytoin; D010634:Phenobarbital
Studio sperimentale comparativo dell'azione antiepilettica del Clonazepam, della Dintoina sodica e del Fenobarbital somministrati per via parenterale