Stable lipid peroxidation products in human skin: detection, ultraviolet light-induced increase, pathogenic importance.
Products of lipid peroxidation (malonaldehyde, Schiff-bases) were detected in human skin. These products were increased after UV-light exposition, on chronically sun-exposed areas as well as with advancing age. Malonaldehyde cross linked epidermal glucose-6-phosphate-dehydrogenase and diminished their activity.
D000328:Adult; D000368:Aged; D000375:Aging; D000818:Animals; D000831:Animals, Newborn; D005954:Glucosephosphate Dehydrogenase / Q000302:isolation & purification / Q000378:metabolism; D006801:Humans; D050356:Lipid Metabolism; D046911:Macromolecular Substances; D008314:Malonates / Q000378:metabolism*; D008315:Malondialdehyde / Q000378:metabolism*; D008875:Middle Aged; D008970:Molecular Weight; D010545:Peroxides / Q000378:metabolism; D051381:Rats; D012545:Schiff Bases / Q000378:metabolism; D012867:Skin / Q000378:metabolism / Q000528:radiation effects*; D013472:Sunlight; D014466:Ultraviolet Rays
D046911:Macromolecular Substances; D008314:Malonates; D010545:Peroxides; D012545:Schiff Bases; D008315:Malondialdehyde; D005954:Glucosephosphate Dehydrogenase