[A study of immunological efficacy of the oral chemical cholera vaccine on experimental animals].
Three fractions isolated from the culture fluid of the 569B cholera vibrio strain were studied. The fractions differed by the extent of purification, and the content of the toxid and the O-antigen. In intraintestinal application to rabbits all of them caused formation of antitoxins and vibriocidal antibodies in the blood serum. The immunizing dose of the preparations in intraintestinal administration exceeded the dose required for subcutaneous application. Fraction I should be used for Producing tablet form of cholera vaccine because it was least toxic and provided the greatest yield.
D000284:Administration, Oral; D000818:Animals; D000907:Antibodies, Bacterial / Q000096:biosynthesis*; D000942:Antigens, Bacterial; D000992:Antitoxins / Q000032:analysis*; D002771:Cholera / Q000517:prevention & control; D022121:Cholera Vaccines / Q000008:administration & dosage; D005069:Evaluation Studies as Topic; D007279:Injections, Subcutaneous; D011817:Rabbits; D013347:Subcellular Fractions; D013607:Tablets; D014121:Toxoids; D014734:Vibrio cholerae / Q000276:immunology*
D000907:Antibodies, Bacterial; D000942:Antigens, Bacterial; D000992:Antitoxins; D022121:Cholera Vaccines; D013607:Tablets; D014121:Toxoids
Izuchenie immunologicheskoĭ éffektivnosti oral'noĭ kholernoĭ khimicheskoĭ vaktsiny na éksperimental'nykh zhivotnykh