[Effect of psychopharmaceutic agents on cortical potentials and long-lasting post-tetanic changes in excitability released through stimulation of the dental pulp].
Short-time tetanic stimulation of the tooth pulp with square pulses affords, depending on the stimulation parameters selected, a long-lasting facilitation in the response of subsequently applied test stimuli in the sensomotor cortex of rabbits. The benzodiazepin derivatives, chlorodiazepoxide, nitrazepam (10 mg/kg i.p.) and clonazepam (1 mg/kg i.p.) caused suppression of posttetanic facilitation with partly different influences on cortical potentials following individual stimulation. Meprobamate (200 mg/kg i.p.) had no effect on the processes of posttetanic facilitation, while the amplitudes of sensomotor potentials showed a long-lasting reduction on single stimulation. Chloropromazine (2 mg/kg i.p.) showed a rapid and transient inhibition of posttetanic facilitation and reduced the amplitudes of evoked potentials following single stimulation.
D000818:Animals; D003782:Dental Pulp / Q000187:drug effects*; D005071:Evoked Potentials / Q000187:drug effects*; D011817:Rabbits; D013003:Somatosensory Cortex / Q000502:physiology*; D013268:Stimulation, Chemical; D013997:Time Factors; D014149:Tranquilizing Agents / Q000494:pharmacology*
D014149:Tranquilizing Agents
Der Einfluss von Psychopharmaka auf durch Zahnpulpareizung ausgelöste kortikale Potentiale und langanhaltende posttetanische Erregbarkeitsänderungen