title: Restoration of oxygen uptake and blood flow in the rat cerebral cortex after halothane anaesthesia.
abstract: Halothane decreases both the cerebral blood flow (CBF) and the cerebral metabolic rate for oxygen (CMRO2) when given in anaesthetic doses. A recent report (GJEDDE & HINDFELT 1975) suggests that when halothane is administered to rats for 1 hour, CBF and CMRO2 are depressed by about 30 and 40%, respectively, for as long as 4 hours after discontinuation of the halothane anaesthesia. In the present study rats were anaesthetized with 1% halothane for 1 hour, and CBF and CMRO2 were measured at the end of a 30 min recovery period, during which 70% N2O was administered. Comparison with animals maintained on 70% N2O throughout the entire 90 min period showed that previous halothane anaesthesia had no effects on CBF or CMRO2.
mesh_terms: D000768:Anesthesia, General; D000818:Animals; D002560:Cerebrovascular Circulation / Q000187:drug effects*; D006221:Halothane / Q000494:pharmacology*; D008297:Male; D051381:Rats
chemical_list: D006221:Halothane