[Inhibition of monoamineoxidase and day-night-rhythm: correlation of physiological and biochemical parameters (author's transl)].
The motor activity of rats following medication with monoamine-oxidase inhibitors was registered continuously over a period of nine days. At the same time the enzyme activity of monoamineoxidase (MAO) form A and B and the concentration of serotonin, tryptophan, 5-hydroxyindolacetic acid and norepinephrine were measured in brain stem and hippocampi. We draw the following conclusions: 1. The rhythmic changes in the levels of serotonin and norepinephrine play a minor role in the circadian rhythm. 2. MAO-inhibitors influence the timing mechanism. A relationship between this finding and the therapeutic effect on depressed patients is discussed. 3 Dopaminergic neurons antagonize the activation by adrenergic neurons during the dark-period.
D000818:Animals; D001933:Brain Stem / Q000201:enzymology / Q000378:metabolism; D002940:Circadian Rhythm / Q000187:drug effects*; D006624:Hippocampus / Q000201:enzymology / Q000378:metabolism; D007527:Isoenzymes; D008995:Monoamine Oxidase / Q000378:metabolism; D008996:Monoamine Oxidase Inhibitors / Q000494:pharmacology*; D009043:Motor Activity / Q000187:drug effects; D009638:Norepinephrine / Q000378:metabolism; D051381:Rats; D012701:Serotonin / Q000378:metabolism; D012890:Sleep / Q000187:drug effects* / Q000502:physiology
D007527:Isoenzymes; D008996:Monoamine Oxidase Inhibitors; D012701:Serotonin; D008995:Monoamine Oxidase; D009638:Norepinephrine
Hemmung der Monoaminoxidase und Tag-Nacht-Rhythmus: Korrelation zwischen physiologischen und biochemischen Parametern