[Radioimmune method of determining the concentration of digoxin in the blood during treatment of patients with cardiac insufficiency].
Digoxin concentrations were studied in the blood serum of 128 patients with cardiac insufficiency of different etiology (acute myocardial infarction, postinfarction cardiosclerosis, mitral valve disease). Radioimmunoassay with standard kits was employed, the kits containing 125 I-labelled Digoxin. Mean concentrations of Digoxin were determined in the blood serum corresponding to different maintenance doses of the drug. It was found that signs of overdosage usually appear with concentrations exceeding 2.5 ng/ml. Disorders in the renal excretory function in patients with severe edematous syndrome help a prompt cumulation of Digoxin and the development of glucoside intoxication. Some patients demonstrated a reduced Digoxin tolerance in the acute period of their myocardial infarction. The advantages of the radioimmunoassay, especially in severely ill patients with cardiac pathology are emphasized.
D004077:Digoxin / Q000008:administration & dosage* / Q000097:blood / Q000506:poisoning; D006333:Heart Failure / Q000188:drug therapy*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011863:Radioimmunoassay
D004077:Digoxin
Radioimmunnyĭ metod opredeleniia kontsentratsii digoksina v korvi pri lechenii bol'nykh s serdechnoĭ nedostatochnost'iu