title: [Experimentally induced cholera in guinea pigs. I. Elaboration of the method of infection].
abstract: The method of intrapulmonary infection of guinea pigs was suggested for the assessment of the virulent properties of cholera vibrios. Addition into the diluent of 10% peptone, 10% gelatine and 0.05% agar-agar led to the reduction of LD50 by over 1000 times. A specific infectious process coursing in an acute generalized form with bacteriemia and affection of the small intestine developed in the infected animals. The majority of the animals perished in 1 to 2 days.
mesh_terms: D000362:Agar; D000818:Animals; D002771:Cholera / Q000209:etiology*; D004195:Disease Models, Animal; D005780:Gelatin; D006168:Guinea Pigs; D007928:Lethal Dose 50; D010461:Peptones; D014734:Vibrio cholerae / Q000472:pathogenicity; D014774:Virulence
chemical_list: D010461:Peptones; D005780:Gelatin; D000362:Agar
vernacular_title: Eksperimental'naia kholera u morskikh svinok. Soobshchenie I. Razrabotka metoda zarezheniia