Endothelial damage from intraocular lens insertion.
Previous studies have shown that approximately 40 per cent of the corneal endothelial cells can be lost at the time of intraocular lens insertion. Momentary contact between the methacrylate surface and the endothelial cells causes an adhesion between these surfaces and results in extensive cell damage upon separation of the surfaces. This type of damage appears to be due to a biophysical interaction between these surfaces and may be avoidable by altering the surface of the lens.
D000818:Animals; D065306:Corneal Injuries; D004727:Endothelium / Q000473:pathology; D006801:Humans; D066298:In Vitro Techniques; D007909:Lenses / Q000009:adverse effects*; D008689:Methacrylates / Q000009:adverse effects; D008855:Microscopy, Electron, Scanning; D019736:Prostheses and Implants / Q000009:adverse effects*; D011817:Rabbits
D008689:Methacrylates