[Nigrostriatally induced motor reactions in the rat. I. Rotational behavior and posture asymetry after intracerebral injection of apomorphine and dopamine].
Using a rotameter described by Ungrstedt, the influence of pretreatment with 6-hydroxy-dopamine and transections of the Capsula interna on the asymmetry of the animal's poise and movement following systemic and intracerebral administration of dopamine and apomorphine was studied. After lesion of the nigrostriatal tract, i.p. administered apomorphine caused the animals to rotate towards the damaged side. After injection of apomorphine in the Nucleus caudatoputamen of healthy animals, initial rotations towards the injection side with subsequent opposite rotation were observed, whereas dopamine injected into the Nucleus caudatoputamen and the Substantia nigra initiated rotations in contralateral direction only. Pretreatment with haloperidole nullified the effect of apomorphine. The results have proved the effectiveness both in the Nucleus caudatoputamen and the Substantia nigra of drugs stimulating the dopamine receptors. With intact rats, the two sides of the nigrostriatal system are functionally asymmetric, which is reflected by the quantitative differences of responses following stimulation of dopamine-sensitive receptors and the individually different preference of one rotational direction. These individual behavioural patterns are modified by experimental influences.
D000818:Animals; D001058:Apomorphine / Q000008:administration & dosage / Q000494:pharmacology*; D001205:Ascorbic Acid / Q000494:pharmacology; D001921:Brain / Q000473:pathology; D002421:Caudate Nucleus; D004298:Dopamine / Q000008:administration & dosage / Q000494:pharmacology*; D005260:Female; D006220:Haloperidol / Q000494:pharmacology; D006892:Hydroxydopamines / Q000494:pharmacology; D007267:Injections; D009069:Movement Disorders / Q000139:chemically induced*; D011187:Posture / Q000187:drug effects*; D051381:Rats; D011954:Receptors, Dopamine
D006892:Hydroxydopamines; D011954:Receptors, Dopamine; D006220:Haloperidol; D001058:Apomorphine; D001205:Ascorbic Acid; D004298:Dopamine
Nigrostriatal induzierte motorische Reaktionen der Ratte. I. Rotationsverhalten und Haltungsasymmetrie nach intrazerebraler Injektion von Apomorphin und Dopamin