[Disaccharidases of the intestinal mucosa of the rat after cytostatic combined therapy with vincristin sulphate and ifosfamide (author's transl)].
Vincristin sulphate or 3-(2-chloroethyl)-2-(2-chloroethyl-amino)-tetrahydro-2H-1,3,2-oxazaphosphorine-2-oxide (ifosfamide)--given alone--may reduce intestinal disaccharidase activities in the rat. However, combined administration of both the drugs, as used as a therapeutic means, results in a much more drastic decrease in enzyme activities. Consequently, also in man maldigestion of disaccharides might occur due to that polychemotherapy.
D000818:Animals; D003520:Cyclophosphamide / Q000031:analogs & derivatives*; D004186:Disaccharidases / Q000378:metabolism*; D004359:Drug Therapy, Combination; D007069:Ifosfamide / Q000494:pharmacology*; D007413:Intestinal Mucosa / Q000187:drug effects* / Q000201:enzymology; D007421:Intestine, Small / Q000201:enzymology; D008297:Male; D051381:Rats; D014750:Vincristine / Q000494:pharmacology*
D014750:Vincristine; D003520:Cyclophosphamide; D004186:Disaccharidases; D007069:Ifosfamide
Disaccharidasen der Dünndarmschleimhaut der Ratte unter zytostatischer Kombinationsbehandlung mit Vincristinsulfat und Ifosfamid