Preparation of 1-acyl-2-succinyl glycero-3-phosphorylcholine and evidence against its involvement in succinate dehydrogenase action.
1-Acyl-2-succinyl glycero-3-phosphorylcholine (GPC) was synthesized and its properties described. Although 1-acyl-2-succinyl GPC is a good substrate for succinate dehydrogenase, experiments on the incorporation of [2,3-14C] succinate into mitochondrial lipids gave no evidence to indicate that it is an intermediate in the enzymic oxidation of succinate to fumerate, as has been suggested earlier.
D000818:Animals; D003486:Cyanides / Q000494:pharmacology; D005997:Glycerylphosphorylcholine / Q000031:analogs & derivatives*; D008244:Lysophosphatidylcholines; D008862:Microsomes, Liver / Q000187:drug effects / Q000201:enzymology; D008930:Mitochondria, Liver / Q000187:drug effects / Q000201:enzymology; D010740:Phospholipases; D051381:Rats; D012910:Snake Venoms; D013385:Succinate Dehydrogenase / Q000378:metabolism*
D003486:Cyanides; D008244:Lysophosphatidylcholines; D012910:Snake Venoms; D005997:Glycerylphosphorylcholine; D013385:Succinate Dehydrogenase; D010740:Phospholipases