title: Use of bumetanide, a potent diuretic, to obtain urinary samples for dope testing in horses.
abstract: Use of the potent, high-ceiling diuretic bumetanide made it possible to obtain urinary samples for dope testing of trotters within the 1st hour after the race. The drug was injected intravenously at a dose level of 10 mug/kg during the cold season of the year, but on warm days, a dose of 20 mug/kg was more reliable. These doses did not produce any side-effects and did not interfere with the detection of doping drugs, since bumetanide is not metabolized to a detectable degree and the unchanged drug appears only in extracts from acidic urine. By enhancing the clearance of drugs used for doping, bumetanide even provides favorable conditions for detection of such drugs.
mesh_terms: D000662:Amphetamines / Q000652:urine; D000818:Animals; D002034:Bumetanide / Q000494:pharmacology* / Q000652:urine; D004232:Diuretics / Q000494:pharmacology*; D005260:Female; D006736:Horses / Q000652:urine*; D008297:Male; D009994:Osmolar Concentration; D010634:Phenobarbital / Q000652:urine; D012964:Sodium / Q000652:urine; D014556:Urine
chemical_list: D000662:Amphetamines; D004232:Diuretics; D002034:Bumetanide; D012964:Sodium; D010634:Phenobarbital