title: Pseudomembranous colitis associated with antibiotics.
abstract: Colitis associated with antibiotics, particularly with lincomycin and clindamycin, is a well established entity. The colitis may be clinically and radiologically very difficult to distinguish from inflammatory bowel disease, including Crohn's disease and ulcerative colitis. A wide spectrum of pathological features is described with various antibiotics. However, the pathological picture in the pseudomembranous form is quite distinctive. The most important histological findings include a "mushroom-like" or "explosive" appearance of the pseudomembrane with a sudden transition to normal mucosa adjacent to the lesion. Rectal biopsy is both an accurate and a rapid method of establishing the diagnosis.
mesh_terms: D000328:Adult; D000368:Aged; D000667:Ampicillin / Q000009:adverse effects; D000900:Anti-Bacterial Agents / Q000009:adverse effects*; D002981:Clindamycin / Q000009:adverse effects; D004761:Enterocolitis, Pseudomembranous / Q000139:chemically induced* / Q000473:pathology; D005260:Female; D006801:Humans; D008034:Lincomycin / Q000009:adverse effects; D008297:Male; D008875:Middle Aged
chemical_list: D000900:Anti-Bacterial Agents; D002981:Clindamycin; D000667:Ampicillin; D008034:Lincomycin