The protective effects of methysergide, 6-hydroxydopamine and other agents on the toxicity of amphetamine, phentermine, MDA, PMA, and STP in mice.
The ability of various drugs to prevent the lethal effects of 4-methoxyamphetamine (PMA) and 3, 4-methylenedioxyamphetamine (MDA) were reduced by pretreatment with phentolamine and 6-hydroxydopamine suggesting that release of norepinephrine from peripheral adrenergic nerves contributed to their toxicity. Pretreatment with methysergide reduced the lethal effects of (+)- and (-)-amphetamine, MDA, PMA and 2, 5-dimethoxy-4-methylamphetamine (STP) suggesting that an action on serotonergic receptors contributed to their toxicity. Pretreatment with 4-chloroamphetamine, practolol and haloperidol did not alter the lethal effects of the agents studied.
D004290:DOM 2,5-Dimethoxy-4-Methylamphetamine / Q000633:toxicity*; D000662:Amphetamines / Q000633:toxicity*; D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects; D003864:Depression, Chemical; D003913:Dextroamphetamine / Q000633:toxicity*; D006892:Hydroxydopamines / Q000494:pharmacology*; D007928:Lethal Dose 50; D008297:Male; D008784:Methysergide / Q000494:pharmacology*; D051379:Mice; D008807:Mice, Inbred BALB C; D010645:Phentermine / Q000633:toxicity*
D000662:Amphetamines; D006892:Hydroxydopamines; D004290:DOM 2,5-Dimethoxy-4-Methylamphetamine; D010645:Phentermine; D003913:Dextroamphetamine; D008784:Methysergide