[Mechanism of action of parenterally administered protein hydrolysates on gastric secretion].
Tests were conducted on dogs with a gastric fistula and removal of the structure associated with the formation of antral gastrin (mucosectomy of the antral portion of the stomach). In another series of experiments use was made of dogs with Basov's fistula, isolated Pavlov's and Haidenhain's pouches. The basic mechanism of action exerted by apparently introduced proteinic hydrolysates on the gastric secretion was found to be of nervous nature. This is evidenced by the fact of an abrupt suppression of secretion following a preliminary injection of atropine, by a less abundant secretion in dogs with a vagus-denervated isolated pouch and, finally, by the absence of any significant differences in the gastric secretion of dogs with mucosectomized antral segment of the stomach and in control ones.
D000818:Animals; D001285:Atropine / Q000494:pharmacology; D002364:Caseins; D004285:Dogs; D005750:Gastric Juice / Q000378:metabolism*; D005753:Gastric Mucosa / Q000294:innervation / Q000378:metabolism; D005755:Gastrins / Q000378:metabolism; D007275:Injections, Intravenous; D010455:Peptides / Q000494:pharmacology; D011492:Protein Hydrolysates / Q000494:pharmacology*; D014630:Vagus Nerve / Q000187:drug effects
D002364:Caseins; D005755:Gastrins; D010455:Peptides; D011492:Protein Hydrolysates; D001285:Atropine
O mekhanizme deĭstviia parenteral'no vvedennykh belkovykh gidrolizatov na zheludochnuiu sekretsiiu