Afferent and efferent interference of cell-mediated cytotoxic reactions by heparin.
Heparin influenced the induction (afferent interference) and effector (efferent interference) phases of cell-mediated cytotoxic reactions against FBL-3 cells, a syngeneic Friend virus-induced leukemia in inbred C57BL/6 mice. Heparin was cytotoxic at high concentrations (greater than or equal to 100 U/ml) and inhibitory for cell-mediated cytotoxic response at lower concentrations (less than or equal to 50 U/ml).
D000818:Animals; D003601:Cytotoxicity Tests, Immunologic; D005622:Friend murine leukemia virus; D006493:Heparin / Q000494:pharmacology*; D007111:Immunity, Cellular / Q000187:drug effects*; D007942:Leukemia, Experimental / Q000276:immunology*; D051379:Mice; D008810:Mice, Inbred C57BL
D006493:Heparin