Immuno-electron microscopic study of the distribution of the S 100 protein in brain glial cells.
The distribution of the brain-specific S 100 protein was studied by an immunohistochemical method at the ultrastructural level. The S 100 protein was localized in the plasma membrane of astrocytes, oligodendrocytes and neurons, but not in that of endothelial cells and pericytes. Astrocytic filaments also possessed S 100 activity. The vascular basement membrane lacked traces of S 100.
D000818:Animals; D000937:Antigen-Antibody Reactions; D001253:Astrocytes / Q000032:analysis* / Q000648:ultrastructure; D001485:Basement Membrane / Q000032:analysis; D001923:Brain Chemistry; D002462:Cell Membrane / Q000032:analysis; D004721:Endoplasmic Reticulum / Q000032:analysis; D004727:Endothelium / Q000166:cytology; D008297:Male; D008854:Microscopy, Electron; D008870:Microtubules / Q000032:analysis; D008928:Mitochondria / Q000032:analysis; D009457:Neuroglia / Q000032:analysis*; D009836:Oligodendroglia / Q000032:analysis / Q000648:ultrastructure; D011506:Proteins / Q000032:analysis*; D051381:Rats
D011506:Proteins