[The influence of naftidrofuryl on 32Pi-incorporation into nucleic acids and adenosine phosphates of the rat brain].
3-(1-Naphthyl)-2-tetrahydrofuryl-propionic acid-beta-diethylester-hydrogenoxalate (naftidrofuryl) increased after a 15-day treatment with orally 200 mg/kg per day the 32P-incorporation rate of two nucleic acid fractions and of ATP, ADP and AMP of rat brains. In contrast to the findings of other authors no increased ATP content was observed. The increased incorporation of the alpha-phosphate during the de novo synthesis of AMP.
D000227:Adenine Nucleotides / Q000096:biosynthesis*; D000818:Animals; D001921:Brain / Q000378:metabolism*; D005260:Female; D005663:Furans / Q000494:pharmacology*; D009257:Nafronyl / Q000494:pharmacology*; D010710:Phosphates / Q000378:metabolism; D012313:RNA / Q000096:biosynthesis*; D051381:Rats
D000227:Adenine Nucleotides; D005663:Furans; D010710:Phosphates; D009257:Nafronyl; D012313:RNA
Der einfluss von Naftidrofuryl auf den 32Pi-einbau in Nukleinsäuren und Adenosinphosphate des Rattengehirns