Sensitization of the smooth muscle by prostaglandin E1 contributes to reversal of drug-induced inhibition of the guinea-pig ileum.
Prostaglandin (PG)E1 reverses drug-induced inhibition of the electrically stimulated guinea-pig ileum. The effect of PGE1 is in part related to a sensitizing action on the smooth muscle and in part to an increased acetylcholine release from the myenteric plexus.
D000109:Acetylcholine / Q000378:metabolism; D000818:Animals; D004558:Electric Stimulation; D006168:Guinea Pigs; D007082:Ileum / Q000187:drug effects; D008297:Male; D009020:Morphine / Q000037:antagonists & inhibitors*; D009130:Muscle, Smooth / Q000187:drug effects*; D009197:Myenteric Plexus / Q000187:drug effects / Q000378:metabolism; D011458:Prostaglandins E / Q000494:pharmacology*; D013779:Tetrodotoxin / Q000037:antagonists & inhibitors
D011458:Prostaglandins E; D013779:Tetrodotoxin; D009020:Morphine; D000109:Acetylcholine