Sterility induced in male rats by injection of chemical agents into the vas deferens.
Changes in the histopathology of the testes with the epididymis were studied 3 months and 6 months after vasocclusion either with ethanol urea mixture or ethanol alone in male rats. A gradual decrease in the fertility of treated animals was observed. The epididymis showed tubules with sperm granuloma and the testis showed empty tubules with Leydig cell hyperplasia in the urea-ethanol treated animals.
D000818:Animals; D004822:Epididymis / Q000473:pathology; D000431:Ethanol; D007248:Infertility, Male / Q000139:chemically induced* / Q000473:pathology; D008297:Male; D051381:Rats; D013091:Spermatogenesis / Q000187:drug effects*; D013737:Testis / Q000473:pathology; D014508:Urea; D014649:Vas Deferens / Q000187:drug effects* / Q000473:pathology
D000431:Ethanol; D014508:Urea