Inhibition and stimulation by 5-bromodeoxyuridine of erythropoiesis by chick blood island cells.
Erythropoiesis in liquid cultures of cell populations resolved from chick blastodiscs at the primitive streak and head-fold stages was totally inhibited by 5-8 mug/ml of 5-bromodeoxyuridine. However, concentrations of 0.2 mug/ml of the nucleoside enhanced the number of erythroid cells formed.
D000818:Animals; D001973:Bromodeoxyuridine / Q000494:pharmacology*; D002478:Cells, Cultured; D002642:Chick Embryo; D004305:Dose-Response Relationship, Drug; D004920:Erythropoiesis / Q000187:drug effects*
D001973:Bromodeoxyuridine