Immunological impairment and susceptibility to infection after splenectomy.
Asplenic patients or those who have undergone splenectomy are prone to overwhelming and often fatal sepsis, which is sometimes associated with disseminated intravascular coagulopathies. Although several pathogens are involved, the most common organism found in these subjects is the pneumococcus, and the infections respond poorly to antibiotic therapy.
D000818:Animals; D000917:Antibody Formation; D006801:Humans; D007074:Immunoglobulin G / Q000096:biosynthesis; D007075:Immunoglobulin M / Q000096:biosynthesis; D007153:Immunologic Deficiency Syndromes / Q000209:etiology*; D007239:Infections / Q000276:immunology*; D013154:Spleen / Q000002:abnormalities / Q000276:immunology*; D013156:Splenectomy / Q000009:adverse effects*
D007074:Immunoglobulin G; D007075:Immunoglobulin M