[On the molecular biology of the ageing. VI. Information. Changes of the protein biosynthesis in the age (author's transl)].
1. Most reports in the literature describe a diminished protein synthesis in the old organism. 2. The diminished protein synthesis may be the result of changes of ribosomes, unequal concentration of endogen m-RNA, changes of the activity or concentration of cytosol factors, especially the influence of SH-substances. 3. The age-dependent changes of protein biosynthesis are dependent on the technique of preparation and on the nutrition state of the organism. 4. Addition of 2-mercaptoethanol during preparation or to the incubation medium decreases the age-dependent differences of protein synthesis.
D000375:Aging; D000818:Animals; D003600:Cytosol / Q000378:metabolism; D008623:Mercaptoethanol / Q000494:pharmacology; D051379:Mice; D008861:Microsomes / Q000378:metabolism; D014176:Protein Biosynthesis; D012313:RNA / Q000378:metabolism; D051381:Rats; D012270:Ribosomes / Q000378:metabolism; D013438:Sulfhydryl Compounds / Q000494:pharmacology
D013438:Sulfhydryl Compounds; D008623:Mercaptoethanol; D012313:RNA
Zur Molekularbiologie des Alterns. VI. Veränderungen der Proteinsynthese im Alter