[Study on the protective effect of vitamin A on stress ulcer of the rat (author's transl)].
The protective effect of vitamin A on "restraint stress" ulcer formation was studied in rats. Animals receiving i.m. injections of 1000 or 2000 IU vitamin A, respectively, every 6 h after 19 h of immobilisation had significantly fewer and smaller ulcers than had the controls. There was no difference between the 2 doses. Only a few rats had no gastric ulcers at all, that means the protection was not absolute. Therapeutic use of vitamin A in the prophylaxis of stress ulcer is discussed.
D000818:Animals; D004305:Dose-Response Relationship, Drug; D007103:Immobilization; D008297:Male; D051381:Rats; D013276:Stomach Ulcer / Q000209:etiology / Q000517:prevention & control*; D013312:Stress, Physiological; D014801:Vitamin A / Q000627:therapeutic use*
D014801:Vitamin A
Untersuchung zur protektiven Wirkung von Vitamin A beim Stressulkus der Ratte