title: Phrenic nerve activity and occlusion pressure changes during CO2 rebreathing in cats.
abstract: Changes in phrenic nerve activity, quantified as a moving time average, PNG(t), were characterized during complete airway occlusion at functional residual capacity (FRC) and compared to simultaneously occurring changes in intratracheal pressure. In anesthetized cats breathing room air and during CO2 breathing, PNG(t) during occlusion was the same as that found during unobstructed breathing until it reached a value approximately corresponding to that at peak inspiration in the preceding unoccluded breath, the rate of change of PNG(t) usually remained the same but in a few cases (2 out of 11) increased. When intratracheal occlusion pressure was plotted as a function of PNG(t), both while breathing room air and during CO2 rebreathing, an approximately linear relationship was obtained. Thus, changes in intratracheas occlusion pressure obtained at FRC parallel changes in phrenic motor nerve activity. Quantification of electrical activity of respiratory nerves as a moving time average provides a means of characterizing changes in the average level of electrical activity during an inspiratory effort.
mesh_terms: D000402:Airway Obstruction; D000818:Animals; D002245:Carbon Dioxide; D002415:Cats; D003964:Diaphragm / Q000502:physiology; D005260:Female; D005652:Functional Residual Capacity; D008168:Lung / Q000294:innervation; D008297:Male; D010791:Phrenic Nerve / Q000502:physiology*; D011187:Posture; D011312:Pressure; D012119:Respiration
chemical_list: D002245:Carbon Dioxide