Oxalosis. An unusual cause of myelophthisis in childhood.
In a child with renal failure and oliguria due to hyperoxaluria myelophthisis developed as a result of extensive bone-marrow replacement with calcium oxalate crystals and an accompanying fibrous proliferations. The histopathology associated with this metabolic disorder was demonstrated in posterior iliac crest bone-marrow trephine biopsies, renal biopsies, and nephrectomy specimens. Crystals were demonstrated in biopsy specimens of transplanted kidneys within six weeks following renal transplantation.
D000750:Anemia, Myelophthisic / Q000209:etiology* / Q000473:pathology; D001853:Bone Marrow / Q000473:pathology; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007668:Kidney / Q000473:pathology; D007669:Kidney Calculi / Q000209:etiology / Q000473:pathology; D008661:Metabolism, Inborn Errors / Q000150:complications* / Q000473:pathology; D010070:Oxalates / Q000378:metabolism*
D010070:Oxalates