Intracisternal dimer X: toxicity and prophylaxis.
Although Dimer X is said to be a low toxic water soluble contrast medium, epileptic seizures sometimes occur during or after Dimer X ventriculography. The toxicity of this dye was examined in rats and possible prophylactic measures were evaluated. From the results of our experiment it was concluded that Dimer X of low concentration should be used with premedication of Valium and Decadron.
D000818:Animals; D002540:Cerebral Cortex / Q000503:physiopathology; D003907:Dexamethasone / Q000627:therapeutic use*; D003975:Diazepam / Q000627:therapeutic use*; D007278:Injections, Spinal; D007482:Iothalamate Meglumine / Q000037:antagonists & inhibitors*; D007483:Iothalamic Acid / Q000031:analogs & derivatives*; D051381:Rats; D012640:Seizures / Q000139:chemically induced* / Q000503:physiopathology / Q000517:prevention & control; D014202:Tremor / Q000139:chemically induced
D007483:Iothalamic Acid; D003907:Dexamethasone; D003975:Diazepam; D007482:Iothalamate Meglumine