The behavioral effects of prenatal hypoxia in the rat.
Pregnant rats were exposed to an oxygen depleted atmosphere (13% oxygen in nitrogen) at normal pressure in 2-hr daily sessions extending over approximately the last 14 days of pregnancy. Their progeny were compared with control progeny in terms of age of eye-opening, open-field behavior, and Hebb-Williams maze problem solving ability. The groups were not distinguishable by their performance in the open-field, but the experimental animals opened their eyes significantly earlier and made significantly more errors on Hebb-Williams maze problems.
D000818:Animals; D000831:Animals, Newborn / Q000254:growth & development*; D001289:Attention Deficit Disorder with Hyperactivity / Q000503:physiopathology; D004193:Discrimination Learning; D004195:Disease Models, Animal; D004644:Emotions; D005106:Exploratory Behavior; D005260:Female; D005311:Fetal Hypoxia / Q000503:physiopathology*; D006801:Humans; D008297:Male; D011247:Pregnancy; D011340:Problem Solving; D051381:Rats; D012107:Research Design