[Negative chrono- and inotropic effect of acetylcholine after its local administration to different parts of the heart].
The application of acetylcholine to the atria of an isolated heart of a frog produces a specific negative chronotropic effect without decreasing its amplitude, while its application to the ventricle -- a specific negative inotropic effect without decelerating the heart contractions rate. The application of atropine to the atria and ventricles eliminates the specific negative chrono- and inotropic effects of acetylcholine. The various ganglion-blocking agents do not eliminate these effects. The existence of a new membrane mechanism of perception of the specific effects of acetylcholine and of their synchronous transmission to the venous-atrial node and the ventricular myocardium is proved to be found in the atria and ventricles.
D000109:Acetylcholine / Q000008:administration & dosage / Q000494:pharmacology*; D003864:Depression, Chemical; D006339:Heart Rate / Q000187:drug effects*; D008297:Male; D009200:Myocardial Contraction / Q000187:drug effects*
D000109:Acetylcholine
Otritsatel'nye khrono- i inotropnyĭ effekty atsetilkholina pri lokal'nom nanesenii ego na razlichnye uchastki serdtsa