Chronic gastric ulcer in the rat produced by wounding at the fundo-antral junction.
Standardized 8-mm mucosal wounds were made in the rat stomach at the rumeno-fundic junction, fundus, fundo-antral junction, and antrum, and examined at intervals up to 8 months. All wounds at the rumeno-fundic junction and fundus were healed within 4 weeks and at the antrum within 12 weeks. The majority of wounds at the fundo-antral junction remained chronic and at 8 months 41 of 50 rats still had ulcers 2 mm or greater in diameter. These findings suggest that the fundo-antral junction is an area which is susceptible to the development of chronic ulcers. This is a simple and reliable method of producing chronic gastric ulcers and does not alter the continuity or disturb the function of the gastrointestinal tract.
D000818:Animals; D002465:Cell Movement; D002908:Chronic Disease; D004847:Epithelial Cells; D004848:Epithelium / Q000648:ultrastructure; D005260:Female; D005753:Gastric Mucosa / Q000293:injuries / Q000473:pathology; D006801:Humans; D011706:Pyloric Antrum / Q000293:injuries*; D051381:Rats; D013276:Stomach Ulcer / Q000209:etiology* / Q000473:pathology; D013997:Time Factors; D014945:Wound Healing; D014947:Wounds and Injuries / Q000150:complications