[Nystatin biosynthesis by inactive mutants of Act. noursei when cultured together].
Inactive mutants of the nystatin-producing organism Act. noursei were selected. When 2 of them were cultivated together, nystatin biosynthesis was restored. The substance or substances restoring the antibiotic biosynthesis was excreted into the culture broth. It had non-protein nature and was stable on storage. Reduction of the nystatin biosynthetic chain proceeded without changes in the cultivation conditions.
D003470:Culture Media; D008770:Methylnitrosourea / Q000494:pharmacology; D009154:Mutation / Q000187:drug effects; D009761:Nystatin / Q000096:biosynthesis*; D013302:Streptomyces / Q000187:drug effects / Q000378:metabolism*; D013997:Time Factors
D003470:Culture Media; D009761:Nystatin; D008770:Methylnitrosourea
Biosintez nistatina neaktivnymi mutantami Act. noursei pri ikh sovmestnom kul'tivirovanii