Acquired resistance to prolonged treatment with intravenous "Arvin" (ancrod).
D000721:Ancrod / Q000276:immunology* / Q000627:therapeutic use; D000917:Antibody Formation; D004351:Drug Resistance; D010450:Endopeptidases / Q000276:immunology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D013923:Thromboembolism / Q000188:drug therapy; D013997:Time Factors
D010450:Endopeptidases; D000721:Ancrod