Trypanosomiasis: an approach to chemotherapy by the inhibition of carbohydrate catabolism.
When the infected mammalian host of Trypanosoma brucei brucei is injected with a solution of the iron chelator salicyl hydroxamic acid and glycerol, the aerobic and anaerobic glucose catabolism of the parasite is blocked and the parasite is rapidly destroyed.
D000818:Animals; D002417:Cattle; D002952:Citric Acid Cycle / Q000187:drug effects; D004195:Disease Models, Animal; D004734:Energy Metabolism / Q000187:drug effects; D005990:Glycerol / Q000494:pharmacology / Q000627:therapeutic use*; D006019:Glycolysis / Q000187:drug effects; D006877:Hydroxamic Acids / Q000494:pharmacology / Q000627:therapeutic use*; D051379:Mice; D051381:Rats; D012457:Salicylamides / Q000494:pharmacology / Q000627:therapeutic use*; D014346:Trypanosoma brucei brucei / Q000187:drug effects / Q000378:metabolism*; D014353:Trypanosomiasis, African / Q000188:drug therapy; D014354:Trypanosomiasis, Bovine / Q000188:drug therapy*
D006877:Hydroxamic Acids; D012457:Salicylamides; D005990:Glycerol