title: Selected lipogenic enzyme activities of swine adipose tissue as influenced by genetic phenotype, age, feeding frequency and dietary energy source.
abstract: The effects of genetic phenotype (lean or obese), age, feeding frequency (ad-libitum or meal-fed) and dietary energy source (starch or lard) on selected enzymatic indices of lipogenesis in swine adipose tissue were investigated. The obese line maintained greater specific activities for citrate cleavage enzyme, glucose-6-phosphate dehydrogenase, 6 phosphogluconate dehydrogenase and malic enzyme compared to the lean line regardless of dietary factors. Dietary lard depressed lipogenic enzyme activity, except that of 6-phosphogluconate dehydrogenase, of adipose tissue homogenates in a similar manner in both genetic phenotypes. The enzymatic indices did not indicate that meal-feeding induced hyperlipogenesis can be produced in swine. The genetic phenotype of swine is the preponderant factor regulating lipogenic enzyme activities compared to dietary manipulations.
mesh_terms: D000273:Adipose Tissue / Q000201:enzymology*; D000367:Age Factors; D000818:Animals; D004734:Energy Metabolism; D005260:Female; D005502:Food; D005838:Genotype; D005954:Glucosephosphate Dehydrogenase / Q000378:metabolism*; D008291:Malate Dehydrogenase / Q000378:metabolism*; D009765:Obesity / Q000235:genetics*; D010734:Phosphogluconate Dehydrogenase / Q000378:metabolism*; D013552:Swine / Q000378:metabolism
chemical_list: D008291:Malate Dehydrogenase; D010734:Phosphogluconate Dehydrogenase; D005954:Glucosephosphate Dehydrogenase