Treatment of Candida ventriculitis and septicaemia with 5-fluoro-cytosine. Combined peroral and intraventricular administration.
A 9-months old patient with a ventricular shunt due to hydrocephalus was treated with intraventricular administration of 5-FC due to Candida ventriculitis with satisfactory clinical response. The intraventricular dose given was 5 mg twice daily for 14 days. The same patient was treated four months later with combined peroral and intraventricular administration of 5-FC also with good clinical response. On both occasions there was no evidence of drug toxicity. The peroral dose given was 100 mg/kg bodyweight/day divided in four doses. A few CSF and serum samples were taken to estimate the concentration of 5-FC. The local installation of 5-FC in an isolated ventriculitis seems to be of special beneficial value whereas fungal septicaemia with ventriculitis needs combination of peroral and intraventricular administration. No increase in resistance against 5-FC could be registered.
D000284:Administration, Oral; D002177:Candidiasis / Q000188:drug therapy*; D002552:Cerebral Ventricles; D003596:Cytosine / Q000031:analogs & derivatives*; D004660:Encephalitis / Q000188:drug therapy* / Q000382:microbiology; D005437:Flucytosine / Q000008:administration & dosage* / Q000627:therapeutic use; D006801:Humans; D007223:Infant; D007276:Injections, Intraventricular; D018805:Sepsis / Q000188:drug therapy* / Q000382:microbiology
D003596:Cytosine; D005437:Flucytosine