Antiviral effects of virazole in chronic hepatitis B surface antigen-seropositive chimpanzees.
Virazole (Ribavirin, ICN 1229), a broad-spectrum, antiviral chemotherapeutic agent was used to treat two adult chronically hepatitis B surface antigen (HB(s) Ag)-seropositive chimpanzees. No significant change in serum hepatitis B surface antigen was noted and no adverse reactions were observed. The role of viral replication in the chronic carrier state of hepatitis B is discussed.
D000818:Animals; D002353:Carrier State; D006509:Hepatitis B / Q000276:immunology; D006514:Hepatitis B Surface Antigens; D006515:Hepatitis B virus / Q000187:drug effects*; D002679:Pan troglodytes; D012254:Ribavirin / Q000494:pharmacology*; D012263:Ribonucleosides / Q000494:pharmacology*
D006514:Hepatitis B Surface Antigens; D012263:Ribonucleosides; D012254:Ribavirin