Uptake of 1-beta-D-arabinofuranosylcytosine and prednisolone by synchronized human lymphoma cells.
The cytotoxicity of many antitumor agents exhibits cell-cycle phase specificity. Using a human lymphoma cell line synchronized by thymidine block, we have investigated the differential uptake of radioactive 1-beta-D-arabinofuranosylcytosine (ara-C) and prednisolone in various phases of the cycle. Uptake of ara-C is highest during early S and declines steadily throughout the rest of the cycle. In comparison, prednisolone demonstrates no significant age-dependent difference in uptake although its cytotoxicity is cell cycle sensitive.
D002455:Cell Division; D002460:Cell Line; D003561:Cytarabine / Q000378:metabolism*; D006801:Humans; D008228:Lymphoma, Non-Hodgkin / Q000378:metabolism*; D011239:Prednisolone / Q000378:metabolism*
D003561:Cytarabine; D011239:Prednisolone