[Synthetic low-molecular weight interferon inducers: derivatives of diaminofluoren-9-one, diaminobenzophenones and diamino biphenyls].
Among the aminoacyl derivatives of 2,7-diaminofluoren-9-one a few compounds were found capable of inducing interferon in the mouse when administered perorally. One of them, 2,7-bis[(diethylamino)acetylamino]fluoren-9-one exhibited an inducing activity comparable to that of 2,7-bis-(2-diethylaminoethoxy)-fluoren-9-one (tilorone). The synthesis of derivatives of fluorene, fluorenol, fluorenone, diaminobenzophenone, diaminiodiphenylmethane and benzidine, all of them with corresponding side chains, allowed to establish structural requirements for interferon inducing capability.
D000577:Amides / Q000138:chemical synthesis / Q000494:pharmacology; D000611:Aminobiphenyl Compounds / Q000138:chemical synthesis* / Q000494:pharmacology; D000818:Animals; D001577:Benzophenones / Q000138:chemical synthesis* / Q000494:pharmacology; D003959:Diamines / Q000138:chemical synthesis / Q000494:pharmacology; D005449:Fluorenes / Q000138:chemical synthesis* / Q000494:pharmacology; D007369:Interferon Inducers / Q000138:chemical synthesis*; D051379:Mice; D013329:Structure-Activity Relationship; D010948:Viral Plaque Assay
D000577:Amides; D000611:Aminobiphenyl Compounds; D001577:Benzophenones; D003959:Diamines; D005449:Fluorenes; D007369:Interferon Inducers
Synthetische niedermolekulare Induktoren von Interferon. 1. Mitteilung: Derivate des Diaminofluoren-9-ons, Diaminobenzophenons und Diaminobiphenyls