Selectivity of proteinuria during pregnancy assessed by different methods.
Relative protein clearance measurements have gone a long way toward characterizing the nature of pregnancy proteinuria but have failed to distinguish between preeclampsia and primary renal disease. The prognostic significance of different degrees of selectivity has been a source of disagreement in past studies. The polymer clearance studies reported here, using tracer doses of labeled PVP, have demonstrated two forms of proteinuria: a benign form due to a vasoconstrictor effect where fetal outlook is good ("vasoactive"), and a form associated with intravascular coagulation which indicates worse fetal prognosis ("membranous"). Underlying chronic renal damage of minor degree is identifiable with PVP clearance. Concurrent measurements of protein clearance, using smaller-sized proteins than is customary, gave hope for future development of meaningful clinical tests.
D005260:Female; D006801:Humans; D006973:Hypertension / Q000503:physiopathology / Q000652:urine*; D007226:Infant Mortality; D007231:Infant, Newborn; D007236:Infant, Small for Gestational Age; D007678:Kidney Glomerulus / Q000503:physiopathology; D011205:Povidone / Q000652:urine; D011225:Pre-Eclampsia / Q000503:physiopathology / Q000652:urine*; D011247:Pregnancy; D011248:Pregnancy Complications / Q000503:physiopathology / Q000652:urine*; D011249:Pregnancy Complications, Cardiovascular / Q000503:physiopathology / Q000652:urine; D011506:Proteins / Q000502:physiology; D011507:Proteinuria / Q000503:physiopathology; D011644:Puerperal Disorders / Q000503:physiopathology / Q000652:urine
D011506:Proteins; D011205:Povidone