Treatment of cutaneous ulcers with benzoyl peroxide.
Benzoyl peroxide, a powerful organic oxidizing agent, was applied topically according to a carefully developed technique to cutaneous ulcers of different types. The healing time was shortened greatly by the rapid development of healthy granulation tissue and the quick ingrowth of epithelium. Exceptionally large pressure ulcers with deep cavities, undercut edges and sinus tracts were sucessfully treated, as were stasis ulcers of long duration resistant to all other therapy. There were only 13 treatment failures among the 133 cases. The slow, sustained release of oxygen by benzoyl peroxide was though to be responsible for the success. The only complications were contact irritant dermatitis in 3% and contact allergic dermatitis in 2% of patients treated.
D000287:Administration, Topical; D000328:Adult; D000368:Aged; D001585:Benzoyl Peroxide / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D008297:Male; D008722:Methods; D008875:Middle Aged; D010545:Peroxides / Q000627:therapeutic use*; D012883:Skin Ulcer / Q000188:drug therapy* / Q000473:pathology
D010545:Peroxides; D001585:Benzoyl Peroxide