The influence of kinins on the action of circulatory drugs. I. The influence of kinins on hypertensive and hypotensive effects of selected drugs.
The influence of bradykinin and kallikrein on the action of norepinephrine, epinephrine, isoprenaline, phentolamine, propranolol, aminophylline and theophylline on blood pressure was studied. The kinins potentiated the hypertensive action of norepinephrine and epinephrine, weakened the hypotensive action of isoprenaline, potentiated the hypotensive action of propranolol, and had no effect on the action of phentolamine, aminophylline and theophylline.
D000628:Aminophylline / Q000494:pharmacology; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects*; D001920:Bradykinin / Q000494:pharmacology; D002415:Cats; D004837:Epinephrine / Q000494:pharmacology; D007545:Isoproterenol / Q000494:pharmacology; D007610:Kallikreins / Q000494:pharmacology; D007705:Kinins / Q000494:pharmacology*; D008297:Male; D009638:Norepinephrine / Q000494:pharmacology; D010646:Phentolamine / Q000494:pharmacology; D051381:Rats; D013806:Theophylline / Q000494:pharmacology
D007705:Kinins; D000628:Aminophylline; D013806:Theophylline; D007610:Kallikreins; D007545:Isoproterenol; D001920:Bradykinin; D009638:Norepinephrine; D004837:Epinephrine; D010646:Phentolamine