[Experimental studies on pramiverine (author's transl)].
A preventive effect of 4,4-diphenyl-N-isopropyl-cyclohexylamine-hydrochloride (pramiverine, Sistalgin) was determined on the experimental gastric ulcer in rats. In 14 patients with duodenal ulcers the maximally stimulated gastric secretion was significantly reduced by 50% after pramiverine, which may serve as a reliable criterium for the evaluation of prospective surgical vagotomy. Electromyographic examinations of stomach and duodenum demonstrated the decrease of spontaneous pressure waves in patients and the pressure increases induced by neostigmine. During hypotensive duodenography without the introduction of a probe, pramiverine by a prolonged reduction of motility permits excellent radiological diagnosis in the duodenum and jejunum.
D000818:Animals; D001559:Benzhydryl Compounds / Q000494:pharmacology / Q000627:therapeutic use; D003514:Cyclohexylamines / Q000494:pharmacology* / Q000627:therapeutic use; D004064:Digestive System / Q000187:drug effects*; D004381:Duodenal Ulcer / Q000378:metabolism; D004386:Duodenum / Q000000981:diagnostic imaging; D004576:Electromyography; D005750:Gastric Juice / Q000378:metabolism; D005769:Gastrointestinal Motility / Q000187:drug effects; D006632:Histamine / Q000494:pharmacology; D006801:Humans; D010276:Parasympatholytics / Q000627:therapeutic use; D011292:Premedication; D011859:Radiography; D051381:Rats; D013276:Stomach Ulcer / Q000517:prevention & control; D014628:Vagotomy
D001559:Benzhydryl Compounds; D003514:Cyclohexylamines; D010276:Parasympatholytics; D006632:Histamine
Experimentelle Untersuchungen mit Pramiverin