[Proof of the necessity of antiviral protein synthesis in the presence of interferon action].
The previously described cell-free system of combined synthesis of virus components was used for investigation of the mechanism of interferon action. Interferon effect was demonstrated to require the cellular stage of its action. When interferon was added after separation of the microsomal-mitochondrial "factory", no inhibitory effect was observed. The experimental data confirm the concept that interferon induces an antiviral protein coded in cell genome.
D000998:Antiviral Agents / Q000096:biosynthesis*; D002478:Cells, Cultured; D004666:Encephalitis Virus, Venezuelan Equine / Q000187:drug effects*; D007372:Interferons / Q000494:pharmacology*; D008861:Microsomes / Q000378:metabolism; D008928:Mitochondria / Q000378:metabolism; D014176:Protein Biosynthesis; D013268:Stimulation, Chemical; D014779:Virus Replication / Q000187:drug effects*
D000998:Antiviral Agents; D007372:Interferons
Dokazatel'stvo neobkhodimosti sinteza antivirusnogo belka pri deĭstvii interferona