Effects of prostaglandins in canine endotoxin shock.
Endotoxin shock was produced in healthy, adult mongrel dogs by the intravenous injection of 1.5 mg/kg of E. coli endotoxin. The 24 hour survival of untreated animals was 34% and was not enhanced by volume replacement with low molecular weight dextran. Treatment with dextran and prostaglandin A1 or E1, although effecting significant hemodynamic improvements, did not increase survival.
D000818:Animals; D003911:Dextrans / Q000627:therapeutic use; D004195:Disease Models, Animal; D004285:Dogs; D006439:Hemodynamics / Q000187:drug effects; D011454:Prostaglandins A / Q000494:pharmacology / Q000627:therapeutic use*; D011458:Prostaglandins E / Q000494:pharmacology / Q000627:therapeutic use*; D012772:Shock, Septic / Q000188:drug therapy*
D003911:Dextrans; D011454:Prostaglandins A; D011458:Prostaglandins E