Changes in the concentration of adenohypophyseal prolactin and morphological manifestations in the adenohypophysis of lactating rats after administration of D-6-methyl-8-[beta-isopropylaminoethyl] ergoline-I.
The four days administration of D-6-methyl-8-[beta-isopropylaminoethyl]ergoline-I (VUFB-10726) to nursing rats decreases adenohypophyseal prolactin as determined with disc electrophoresis, and produces changes in the histological appearance of adenohypophyses, which indicate the inhibition of prolaction production and secretion.
D000818:Animals; D004873:Ergolines / Q000494:pharmacology*; D005260:Female; D007774:Lactation; D010902:Pituitary Gland / Q000187:drug effects*; D010903:Pituitary Gland, Anterior / Q000166:cytology / Q000187:drug effects*; D011247:Pregnancy; D011388:Prolactin / Q000378:metabolism*; D051381:Rats
D004873:Ergolines; D011388:Prolactin