title: Approaches to the study of acetylcholine turnover in brain.
abstract: All of the methods presently available for estimating acetylcholine turnover have severe limitations and rest on unproven and sometimes fallacious assumptions. Taken individually, they may be misleading. To the extent that the assumptions are different for different approaches, agreement between several approaches may provide satisfactory evidence regarding normal turnover rates and changes which may be experimentally induced.
mesh_terms: D000109:Acetylcholine / Q000378:metabolism*; D000818:Animals; D001679:Biogenic Amines / Q000378:metabolism; D001921:Brain / Q000378:metabolism*; D001923:Brain Chemistry; D002794:Choline / Q000378:metabolism; D003964:Diaphragm / Q000378:metabolism; D005727:Ganglia, Spinal / Q000378:metabolism; D007553:Isotope Labeling; D007700:Kinetics; D008722:Methods; D010791:Phrenic Nerve / Q000378:metabolism; D013997:Time Factors
chemical_list: D001679:Biogenic Amines; D002794:Choline; D000109:Acetylcholine