Release of renal kallikrein to the perfusate by isolated rat kidney.
The addition of furosemide to the fluid used to perfuse isolated rat kidney increases the kallikrein activity found in the perfusion fluid. The experiments favour the concept that furosemide activates a kallikrein precursor or/and the synthesis and release of kallikrein in the kidneys.
D000818:Animals; D005665:Furosemide / Q000494:pharmacology*; D007610:Kallikreins / Q000378:metabolism* / Q000652:urine; D007668:Kidney / Q000187:drug effects / Q000378:metabolism* / Q000502:physiology; D008297:Male; D051381:Rats
D005665:Furosemide; D007610:Kallikreins