Effect of Ovulen-50(ethynodiol diacetate 1 mg and ethynyloestradiol 0,05 mg) on protein, nucleic acids and nucleases in the rat liver.
Treatment of adult female rats with Ovulen-50 (ethynodiol diacetate 1.0 mg and ethynyloestradiol 0.05 mg--one tenth tablet per day) led to a small but significant fall in total protein, RNA and DNA content of the liver. Alkaline and acid DNAse activity also tended to decline, whereas alkaline RNAase tended to show a marginal rise after twentyfour days of treatment.
D000818:Animals; D004247:DNA / Q000378:metabolism*; D003851:Deoxyribonucleases / Q000378:metabolism; D004338:Drug Combinations; D004997:Ethinyl Estradiol / Q000494:pharmacology*; D005040:Ethynodiol Diacetate / Q000494:pharmacology*; D005260:Female; D008099:Liver / Q000378:metabolism*; D011506:Proteins / Q000378:metabolism*; D012313:RNA / Q000378:metabolism*; D051381:Rats; D012260:Ribonucleases / Q000378:metabolism; D013997:Time Factors
D004338:Drug Combinations; D011506:Proteins; D004997:Ethinyl Estradiol; D005040:Ethynodiol Diacetate; D012313:RNA; D004247:DNA; D003851:Deoxyribonucleases; D012260:Ribonucleases