Studies on the modification of renal lesions due to aspirin and oxyphenbutazone in the rat and the effects on the kidney of 2:4 dinitrophenol.
Cortical tubular necrosis induced by either aspirin (300 mg/kg) or oxyphenbutazone (444 mg/kg) was reduced if probenecid (300 mg/kg) was administered at the same time. The prior administration of aspirin (600 mg/kg) reduced the tubular necrosis that follows administration of oxyphenbutazone (444 mg/kg) alone, thus demonstrating that some degree of cross-tolerance between the two drugs occurs. Phenacetin pretreatment (597 mg/kg) was less effective, while paracetamol (503 mg/kg) was without effect in this regard. Those substances that reduced the oxyphenbutazone-induced cortical lesion also ameliorated the focal degenerative change in the lower nephron attributed to this drug. Oral administration of 2:4 dinitrophenol (20 mg/kg) led to only minor cortical tubular necrosis in a few animals.
D000082:Acetaminophen / Q000627:therapeutic use; D058186:Acute Kidney Injury / Q000139:chemically induced*; D000818:Animals; D001241:Aspirin / Q000627:therapeutic use / Q000633:toxicity*; D004140:Dinitrophenols / Q000633:toxicity*; D005260:Female; D007683:Kidney Tubular Necrosis, Acute / Q000139:chemically induced* / Q000517:prevention & control; D010113:Oxyphenbutazone / Q000633:toxicity*; D010615:Phenacetin / Q000627:therapeutic use; D011339:Probenecid / Q000627:therapeutic use; D051381:Rats
D004140:Dinitrophenols; D000082:Acetaminophen; D010615:Phenacetin; D010113:Oxyphenbutazone; D011339:Probenecid; D001241:Aspirin