Interference of bronchographic agents with lung surfactant.
Dionosil Oily (a suspension of propyliodone crystals in peanut oil and powdered tantalum were introduced into the right principal bronchi of rabbit lungs. The left lungs were used as controls. Pressure-volume characteristics of excised lungs with Dionosil Oily or peanut oil demonstrated significantly reduced compliance on inflation at a pressure of 3-4 cm H2O. These lungs also retained less air on deflation and therefore demonstrated a significantly reduced stability index. Histological sections revealed microatelectasis closely associated with crystals and/or peanut oil. Lungs with tantalum powder were not measurably influenced by the bronchographic agents. Surface balance experiments with lung surfactant and synthetic dipalmitoyl phosphatidylcholine (DPPC) demonstrated an increased minimum surface tension due to the oil suspension of propyliodone, peanut oil and particles (propyliodone and tantalum). There is good evidence that the oil suspension of propyliodone reduced the surface activity of lung surfactant in situ. Particles also may prevent the minimum surface tension from reaching relatively low values if they enter the alveoli in sufficient quantities.
D000818:Animals; D010367:Arachis; D001995:Bronchography / Q000009:adverse effects*; D003287:Contrast Media / Q000009:adverse effects*; D004305:Dose-Response Relationship, Drug; D008170:Lung Compliance / Q000187:drug effects; D008176:Lung Volume Measurements; D009821:Oils / Q000009:adverse effects; D011440:Propyliodone / Q000009:adverse effects; D011650:Pulmonary Alveoli / Q000187:drug effects / Q000473:pathology; D001261:Pulmonary Atelectasis / Q000139:chemically induced / Q000473:pathology / Q000503:physiopathology; D011663:Pulmonary Surfactants / Q000502:physiology*; D011817:Rabbits; D013499:Surface Properties; D013500:Surface Tension; D013635:Tantalum / Q000009:adverse effects
D003287:Contrast Media; D009821:Oils; D011663:Pulmonary Surfactants; D011440:Propyliodone; D013635:Tantalum