Thromboxane - synthesizing activity in guinea pig lung microsomes.
The microsomal fraction of guinea pig lung contains the enzymatic activity that converts arachidonic acid to thromboxane B2. The properties of guinea pig lung enzyme are generally similar to the human platelet enzyme, except the lung enzyme is unstable at 37 degrees C. No difference in total enzymatic activity is observed in the normal and sensitized guinea pig lungs.
D000818:Animals; D004837:Epinephrine / Q000494:pharmacology; D006168:Guinea Pigs; D006880:Hydroxy Acids / Q000378:metabolism*; D066298:In Vitro Techniques; D008168:Lung / Q000648:ultrastructure*; D008297:Male; D008706:Methemoglobin / Q000494:pharmacology; D008861:Microsomes / Q000201:enzymology*; D011714:Pyrans / Q000378:metabolism*; D013997:Time Factors; D014364:Tryptophan / Q000494:pharmacology
D006880:Hydroxy Acids; D011714:Pyrans; D014364:Tryptophan; D008706:Methemoglobin; D004837:Epinephrine