The influence of methylxanthines on precursor incorporation into protein and RNA of mouse brain.
Pentoxifyline at 1 mM had no effect on [14C]isoleucine incorporation into mouse brain tissue suspension. At 5-20 mM, this compound inhibited incorporation. The inhibition was prompt, and it was reversible. Aminophyline at 3-12 mM produced inhibition, but theophyline at 2-16 mM had no effect. Pentoxifylline inhibited the incorporation of uridine into brain RNA to the same extent and with a similar time course as its effect on protein synthesis.
D000628:Aminophylline / Q000494:pharmacology; D000818:Animals; D000831:Animals, Newborn; D001921:Brain / Q000187:drug effects / Q000378:metabolism*; D003513:Cycloheximide / Q000494:pharmacology; D007532:Isoleucine / Q000378:metabolism; D051379:Mice; D008815:Mice, Inbred Strains; D009419:Nerve Tissue Proteins / Q000096:biosynthesis*; D010406:Penicillins / Q000494:pharmacology; D010431:Pentoxifylline / Q000494:pharmacology; D012313:RNA / Q000096:biosynthesis*; D013307:Streptomycin / Q000494:pharmacology; D013806:Theophylline / Q000494:pharmacology; D013997:Time Factors; D014529:Uridine / Q000378:metabolism; D014970:Xanthines / Q000494:pharmacology*
D009419:Nerve Tissue Proteins; D010406:Penicillins; D014970:Xanthines; D007532:Isoleucine; D000628:Aminophylline; D012313:RNA; D003513:Cycloheximide; D013806:Theophylline; D010431:Pentoxifylline; D014529:Uridine; D013307:Streptomycin