[The action of tiadenol on compensatory hypertrophy of the liver in the rat].
The regenerating rat liver after partial hepatectomy was used as a model to study the effects of an hypolipidaemic drugs, tiadenol (bis hydroxyethylthio 1--10 decane). Seven days after partial hepatectomy, liver weight, DNA, RNA, total protein and cytochrome P-450 were increased in tiadenol treated rats, relative to hepatectomized controls. Tiadenol displaying similar effects on the intact liver, it is concluded that this hypolipidaemic drug maintains its hepatomegalic action on the regenerating rat liver.
D000818:Animals; D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism; D004247:DNA / Q000378:metabolism; D005233:Fatty Alcohols / Q000494:pharmacology*; D006498:Hepatectomy; D000960:Hypolipidemic Agents / Q000494:pharmacology*; D008099:Liver / Q000201:enzymology / Q000378:metabolism; D008115:Liver Regeneration / Q000187:drug effects*; D008297:Male; D009929:Organ Size / Q000187:drug effects; D011506:Proteins / Q000378:metabolism; D012313:RNA / Q000378:metabolism; D051381:Rats
D005233:Fatty Alcohols; D000960:Hypolipidemic Agents; D011506:Proteins; C004568:tiadenol; D012313:RNA; D004247:DNA; D003577:Cytochrome P-450 Enzyme System
Action du tiadénol sur l'Hypertrophie compensatrice du foie chez le rat