title: [Studies on the prenatally toxic effect of parathionemethyl in Wistar rats compared to cyclophosphamide and trypan blue].
abstract: Higher yield and performance in plant and animal production will depend on reinforced use of pesticides, particularly alkyl phosphate esters and insecticidal carbamates. Prenatal toxic action of the pesticides used today may be detrimental to human and animal health. Prenatal-toxicological tests, using parathion-methyl, were conducted on the basis of known but modified experimental methods. The vulnerability of a rat strain was tested by applying to it teratogenic model substances (trypan blue and cyclophosphamide). Several oral applications of parathion-methyl (3 ppm) during the sensitive phases of germ formation and growth (fifth to ninth and eleventh to fifteenth or eleventh to nineteenth days from conception) were followed by clear embryotoxic effects, such as retardation and increased resorption. The average number of resorption sites grew from nine in the control group to 20 in the experimental group. Postnatal malformations were not observed.
mesh_terms: D000014:Abnormalities, Drug-Induced; D000818:Animals; D003520:Cyclophosphamide / Q000633:toxicity*; D010064:Embryo Implantation / Q000187:drug effects; D020964:Embryo Loss; D004622:Embryo, Mammalian / Q000187:drug effects; D005260:Female; D008743:Methyl Parathion / Q000633:toxicity*; D010012:Osteogenesis / Q000187:drug effects; D010278:Parathion / Q000031:analogs & derivatives*; D010929:Placentation / Q000187:drug effects; D011247:Pregnancy; D051381:Rats; D014343:Trypan Blue / Q000633:toxicity*
chemical_list: D008743:Methyl Parathion; D010278:Parathion; D003520:Cyclophosphamide; D014343:Trypan Blue
vernacular_title: Untersuchungen zur pränatal-toxischen Wirkung von Parathion-methyl an Wistarratten im Vergleich zu Cyclophosphamid und Trypanblau