title: Further studies on effects of irrigation solutions on rat bladders.
abstract: Further studies on the effects of certain irrigating fluids on the rat bladder for 18 hours are reported. The results have shown that the degradation product p-choloroaniline is not a significant factor in chlorhexidine-digluconate associated erosive cystitis. A high percentage of kanamycin-colistin and povidone-iodine irrigations were associated with erosive cystitis and suggested a possible complication with human usage. Picloxydine irrigations appeared to have a lower incidence of erosive cystitis but further studies would have to be performed before it could be recommended for use in urological procedures.
mesh_terms: D000814:Aniline Compounds / Q000633:toxicity; D000818:Animals; D003091:Colistin / Q000633:toxicity; D003556:Cystitis / Q000139:chemically induced; D004338:Drug Combinations; D007612:Kanamycin / Q000633:toxicity; D008297:Male; D010879:Piperazines / Q000633:toxicity; D011206:Povidone-Iodine / Q000633:toxicity; D051381:Rats; D012996:Solutions; D007507:Therapeutic Irrigation; D001743:Urinary Bladder / Q000187:drug effects*
chemical_list: D000814:Aniline Compounds; D004338:Drug Combinations; D010879:Piperazines; D012996:Solutions; D007612:Kanamycin; D011206:Povidone-Iodine; D003091:Colistin