title: Absorption, excretion, and tissue deposition of titanium in sheep.
abstract: Titanium metabolism was measured in three 18 kg lambs each fed 450 g chopped hay daily. Two of the lambs were dosed orally and one intravenously with 3 muCi titanium-44 each. Clearance of the intravenous dose was extremely slow; after oral administration, however, no titanium-44 was detected in blood plasma for 48 h. Over 96% of the oral dose was recovered in feces and digestive tract contents. Titanium-44 absorption, estimated from total carcass recovery and by comparison of concentrations in internal organs of orally and intravenously dosed lambs, was less than .5%. Fecal titanium could be a satisfactory index of soil ingestion by grazing ruminants.
mesh_terms: D000042:Absorption; D000284:Administration, Oral; D000818:Animals; D001823:Body Composition; D004068:Digestive System Physiological Phenomena; D005243:Feces / Q000032:analysis; D007275:Injections, Intravenous; D012756:Sheep / Q000378:metabolism*; D014025:Titanium / Q000008:administration & dosage / Q000378:metabolism*
chemical_list: D014025:Titanium