[In vivo and in vitro investigations of the effect of decortilen (16-methylenprednisolone) on lecithin synthesis in the fetal lung (author's transl)].
Lecithin synthesis in fetal lungs of the rat over three-fold methylation and over choline and CDP-choline was quantitatively determined via the incorporation rate of marked metabolites. The ability of decortilen to influence both modes of synthesis was investigated. In vivo and in vitro, the glucocorticoid stimulates lecithin formation, which can be as high as 200%, only over choline and CDP-choline.
D000818:Animals; D002794:Choline / Q000378:metabolism; D005260:Female; D006801:Humans; D006819:Hyaline Membrane Disease / Q000517:prevention & control; D066298:In Vitro Techniques; D007231:Infant, Newborn; D008168:Lung / Q000187:drug effects / Q000196:embryology* / Q000378:metabolism; D008745:Methylation; D008775:Methylprednisolone / Q000378:metabolism / Q000494:pharmacology*; D010713:Phosphatidylcholines / Q000096:biosynthesis*; D011247:Pregnancy; D011663:Pulmonary Surfactants / Q000096:biosynthesis*; D051381:Rats
D010713:Phosphatidylcholines; D011663:Pulmonary Surfactants; D002794:Choline; D008775:Methylprednisolone
In vivo und in vitro Untersuchung zur Wirkung von Decortilen (16-Methylenprednisolon) auf die Lezithinsynthese der fetalen Lunge