In vitro studies of poly(methyl methacrylate) adjuvants.
Poly(methyl methacrylate) adjuvants, prepared by polymerizing monomeric methyl methacrylate in the presence of influenza virions or by addition of the virions to previously polymerized poly(methyl methacrylate) particles, were studied by means of the hemagglutination test, antibody binding, and electron microscopy. The results indicated that the virions were coated partly when the polymerization was carried out in the presence of the virus, whereas the virions were probably adsorbed when added to polymerized particles.
D000276:Adjuvants, Immunologic / Q000138:chemical synthesis*; D000327:Adsorption; D000937:Antigen-Antibody Reactions; D006387:Hemagglutination, Viral; D009980:Influenza A virus / Q000276:immunology / Q000378:metabolism; D007252:Influenza Vaccines; D008722:Methods; D008768:Methylmethacrylates / Q000138:chemical synthesis* / Q000276:immunology / Q000378:metabolism; D008854:Microscopy, Electron; D011109:Polymethacrylic Acids / Q000378:metabolism; D012995:Solubility
D000276:Adjuvants, Immunologic; D007252:Influenza Vaccines; D008768:Methylmethacrylates; D011109:Polymethacrylic Acids