[Morphological and cytokinetic studies of the arterial wall following x-ray irradiation. I. Results with 3000 rad. focal irradiation dose in rabbits].
The arterial wall (abdominal aorta, splenic artery) has been investigated after irradiation with 3000 rad (3 X 1000 rad within 3 weeks) in rabbits. In addition to light microscopic techniques semi-thin sections, electron microscopic sections, permeability staining and autoradiographic techniques have been applied. These studies revealed typical lesions in the media (elastic degeneration, cellular proliferation of the smooth muscle cells) and lesions of the endothelial cells using ultrastructural techniques especially. The intima showed an increasing permeability in the irradiated area, while autoradiographically a higher mitotic activity in the media was demonstrable. The results are discussed in the light of similar atherosclerotic and X-ray induced lesions of human blood vessels.
D000818:Animals; D001011:Aorta / Q000473:pathology / Q000502:physiology / Q000528:radiation effects*; D002784:Cholesterol / Q000097:blood; D008938:Mitosis / Q000528:radiation effects; D011817:Rabbits; D013157:Splenic Artery / Q000473:pathology / Q000502:physiology / Q000528:radiation effects*; D014965:X-Rays
D002784:Cholesterol
Morphologische und zelkinetische Untersuchungen an der Arterienwand nach Röntgenbestrahlung. I. Ergebnisse bei 3000rad. Herdbestrahlungsdosis am Kaninchen