The effect of reported prostaglandin synthetase inhibitors on estradiol-stimulated uterine prostaglandin biosynthesis in vivo in the ovariectomized rat.
Aspirin, indomethacin and naproxen have been shown to inhibit the release of prostaglandins E and F (PGE and PGF) from the estradiol-stimulated uterus of progesterone-pretreated ovariectomized rats. Under the present experimental conditions indomethacin (1 mg/rat) was found to be a potent inhibitor of PGF and E biosynthesis, but the duration of action was less than 24 hours, after which a rebound above control levles was observed.The  compounds were without effect on estradiol-stimulated increases in uterine wet weight. delta'THC did not inhibit estradiol-stimulated PG biosynthesis but produced a significant rise (P less than 0.01) in PGE levels in uterine venous blood. A hypothesis is suggested to explain some of the pharmacological effects of delta'THC.
D000818:Animals; D001241:Aspirin / Q000494:pharmacology; D013759:Dronabinol / Q000494:pharmacology; D004958:Estradiol / Q000494:pharmacology*; D005260:Female; D007213:Indomethacin / Q000494:pharmacology; D009288:Naproxen / Q000494:pharmacology; D009929:Organ Size / Q000187:drug effects; D010053:Ovary / Q000502:physiology; D011448:Prostaglandin Antagonists / Q000494:pharmacology*; D011458:Prostaglandins E / Q000096:biosynthesis* / Q000097:blood; D011460:Prostaglandins F / Q000096:biosynthesis*; D051381:Rats; D013997:Time Factors; D014599:Uterus / Q000187:drug effects / Q000378:metabolism
D011448:Prostaglandin Antagonists; D011458:Prostaglandins E; D011460:Prostaglandins F; D004958:Estradiol; D009288:Naproxen; D013759:Dronabinol; D001241:Aspirin; D007213:Indomethacin