[Cytomorphological and enzyme histological studies of bilaterally inoculated Dibromdulcit-sensitive and-resistent Yoshida tumors].
In the bilaterally growing DBD sensitive Yoshida tumours deformed nuclear divisions necrosis of the majority of the tumour and appearance of giant cells can be observed due to the single administration of the LD50 of the preparation. The histochemical activity of the LDH the activity alcalyc Adenosine triphosphatase and the nonspecific alcalyc phosphatase become negative while the acidic phosphatase's activity does increase after the administration of the LD25 of the preparation appearance of giant cells are very marked more than 60% of tumours cells are polynuction. The activity of the alcalyc ATP-ase and nonspecific phosphatase decrose's after a transitory increase and become negative while the acid phosphatase's activity increases. In the case of the DBD resistant tumours the morphological and histochemical alternations due to LD50 of the preparation are much slighter and their timecourse is shorter. No morphological and histochemical changes are observed after the administration of LD25 of the preparation.
D000818:Animals; D066298:In Vitro Techniques; D007928:Lethal Dose 50; D008936:Mitolactol / Q000627:therapeutic use* / Q000633:toxicity; D012517:Sarcoma, Yoshida / Q000188:drug therapy / Q000201:enzymology* / Q000648:ultrastructure
D008936:Mitolactol
Cytomorphologiai és enzimhisztokémiai vizsgálatok bilaterálisan oltott Dibromdulcit-érzékeny és rezisztens Yoshida-tumorokon