[Inducible cephalosporinases from Proteus morganii].
It has been shown that two Proteus morganii strains produce an inducible cephalosporinase. No significative difference was shown between them: they present the same isoelectric poit: 8,3 and very similar kinetic constants. The parameter tau, proportional to the half life of antibiotic at low concentration, in presence of beta lactamase, shows that cefamandole is the most stable cephalosporin studied.
D000581:Amidohydrolases / Q000096:biosynthesis; D000667:Ampicillin / Q000378:metabolism; D001667:Binding, Competitive; D002228:Carbenicillin / Q000378:metabolism; D002510:Cephalosporinase / Q000096:biosynthesis / Q000378:metabolism; D003023:Cloxacillin / Q000378:metabolism; D004790:Enzyme Induction; D007700:Kinetics; D010400:Penicillin G / Q000494:pharmacology; D011511:Proteus / Q000201:enzymology*
D000667:Ampicillin; D000581:Amidohydrolases; D002510:Cephalosporinase; D002228:Carbenicillin; D003023:Cloxacillin; D010400:Penicillin G
Céphalosporinases inductibles de Proteus morganii