title: The effect of halofenate or halofenate free acid on human, rat and guinea pig platelet aggregation.
abstract: Halofenate free acid (HFA), the major metabolite of the hypolipemic agent halofenate, blocked the secondary phase of human platelet aggregation induced by ADP, epinephrine, or thrombin; higher concentrations of clofibrate free acid (CFA) were required to produce similar inhibitory effects on platelet aggregation. HFA and CFA inhibited collagen-induced aggregation of human, rat, or guinea pig platelets. Halofenate orally administered to rats caused inhibition of collagen-induced aggregation when plasma levels of HFA exceeded 300 mug/ml, a clinically achievable human plasma concentration. The platelet inhibitory effects of clofibrate administration were less than those observed with halofenate administration.
mesh_terms: D000818:Animals; D002994:Clofibrate / Q000494:pharmacology; D003094:Collagen; D005260:Female; D006016:Glycolates / Q000494:pharmacology*; D006168:Guinea Pigs; D006218:Halofenate / Q000031:analogs & derivatives / Q000494:pharmacology*; D006801:Humans; D008297:Male; D010974:Platelet Aggregation / Q000187:drug effects*; D051381:Rats; D013552:Swine
chemical_list: D006016:Glycolates; D003094:Collagen; D002994:Clofibrate; D006218:Halofenate