title: [Morphologic basis for several myocardial metabolic disorders in the presence of respiration uncoupled from phosphorylation].
abstract: It was experimentally established that the destruction of mitochondria due to a reduction of ATP production and to their compensatory hyperfunction under energy defecit is underlying some disorders in the myocardial metabolism caused by 2,4-DNP intoxication. Energy deficit results in K+ metabolism disorders and the related acetylcholine synthesis which predisopses the changes in the cardiac function and still further increases the myocardial requirements of energy. The bio-energy disorders develop in a vicious circle manner, and when the intoxication increases, it inevitably results in energy depletion and cardiac arrest.
mesh_terms: D000255:Adenosine Triphosphate / Q000096:biosynthesis; D000818:Animals; D002118:Calcium / Q000378:metabolism; D002682:Chinchilla; D004140:Dinitrophenols; D004734:Energy Metabolism; D005954:Glucosephosphate Dehydrogenase / Q000378:metabolism; D006003:Glycogen / Q000378:metabolism; D006651:Histocytochemistry; D008659:Metabolic Diseases / Q000139:chemically induced* / Q000378:metabolism / Q000473:pathology; D008854:Microscopy, Electron; D008928:Mitochondria / Q000648:ultrastructure; D009206:Myocardium / Q000378:metabolism / Q000473:pathology*; D010101:Oxygen Consumption; D010277:Parasympathomimetics / Q000378:metabolism; D011188:Potassium / Q000378:metabolism; D011817:Rabbits; D012964:Sodium / Q000378:metabolism
chemical_list: D004140:Dinitrophenols; D010277:Parasympathomimetics; D000255:Adenosine Triphosphate; D006003:Glycogen; D012964:Sodium; D005954:Glucosephosphate Dehydrogenase; D011188:Potassium; D002118:Calcium
vernacular_title: Morfologicheskaia osnova nekotorykh narusheniĭ metabolzma miokarda pri razobshchenii dyhaniia i fosforilirovaniia