title: Effect of age and sex on lesions of the esophagus in Buffalo strain rats ingesting diethylnitrosamine.
abstract: Inbred Buffalo male and female rats, 4, 12, 24, and 52 weeks of age, ingested 0.0114% diethylnitrosamine in a semisynthetic diet. Both age and sex were important in the development of preneoplastic and neoplastic lesions of the esophagus. The 4-week-old male rats had notably more carcinomas of the esophagus than female rats of the same age; whereas, 12-week-old male rats had only slightly more carcinomas than the females. The incidence of esophageal lesions was about the same in 24-week-old males and females. Rats 52 weeks of age were not susceptible to esophageal carcinogenesis.
mesh_terms: D000367:Age Factors; D000818:Animals; D004052:Diethylnitrosamine; D004938:Esophageal Neoplasms / Q000139:chemically induced* / Q000473:pathology; D005260:Female; D008113:Liver Neoplasms; D008297:Male; D009362:Neoplasm Metastasis; D009602:Nitrosamines; D011230:Precancerous Conditions / Q000139:chemically induced*; D051381:Rats; D011915:Rats, Inbred BUF; D012737:Sex Factors
chemical_list: D009602:Nitrosamines; D004052:Diethylnitrosamine