title: [Hypopituitarism with hypoplasia of the optic nerve (Kaplan, Grumbach and Hoyt syndrome].
abstract: Two new cases of the syndrome described by Kaplan, Grumbach and Hoyt are reported. The two children were hypopituitary dwarfs, with congenital nystagmus and small optic discs with double border. Pneumoencephalography showed malformations of the median structures, with trans-sphenoidal encephalocele in one case. The definition of this syndrome and its relation to De Morsier's septooptical dysplasia are briefly discussed.
mesh_terms: D002675:Child, Preschool; D004677:Encephalocele / Q000150:complications; D005260:Female; D013006:Growth Hormone / Q000097:blood; D006801:Humans; D007018:Hypopituitarism / Q000150:complications*; D009759:Nystagmus, Pathologic / Q000150:complications; D009900:Optic Nerve / Q000002:abnormalities*; D013285:Strabismus / Q000150:complications; D013577:Syndrome
chemical_list: D013006:Growth Hormone
vernacular_title: Hypopituitarisme avec hypoplasie des nerfs optiques (syndrome de Kaplan, Grumbach et Hoyt