[Penetration of antibiotics into experimental foci of inflammation under the influence of proteolytic enzymes].
The effect of trypsin or chemotrypsin on the levels of benzylpenicillin, ampicillin, oxacillin, kanamycin or tetracycline in the peritoneal inflammation fluid, as well as the effect of trypsin on penetration of these antibiotics into the granulemas of 2 types was studied. It was found that intramuscular administration of the enzymes to animals in a dose of 10 mg/kg resulted in increased levels of penicillins and kanamycin in the inflammation peritoneal fluid. An analogous effect of trypsin was observed with respect to experimental granulemas. The levels of tetracycline in restricted inflammatory foci increased only after intraperitoneal administration of trypsin to rats. Increased penetration of benzylpenicillin into the peritoneal fluid and connective tissue granulema under the effect of the enzymes was observed. The effect of trypsin on penetration of benzylpenicillin into granulema according to Selie did not differ from the effect of the enzyme on penetration of semisynthetic penicillins and kanamycin into it.
D000818:Animals; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D001202:Ascitic Fluid; D001702:Biopharmaceutics; D001769:Blood / Q000187:drug effects; D002918:Chymotrypsin / Q000494:pharmacology; D004347:Drug Interactions; D006099:Granuloma / Q000188:drug therapy*; D007249:Inflammation / Q000188:drug therapy*; D007273:Injections, Intramuscular; D010447:Peptide Hydrolases / Q000494:pharmacology*; D051381:Rats; D014357:Trypsin / Q000494:pharmacology
D000900:Anti-Bacterial Agents; D010447:Peptide Hydrolases; D002918:Chymotrypsin; D014357:Trypsin
Proniknovenie antibiotikov v éksperimental'nye ochagi vospaleniia pod vliianiem proteoliticheskikh fermentov