Evaluation of tobacco hypersensitivity responses in the mouse. A potential animal model for critical study of tobacco allergy.
CFW female mice immunized with tobacco leaf extract developed type 1 skin and mast cell sensitivities that could be quantitated. The presence of both IgG1- and IgE-tobacco-mast-cell-sensitizing antibodies was detected by 2 and 48 h. PCA test. On the basis of these findings, it is suggested that mice can surve as good animal models for critical investigation of tobacco hypersensitivity in the laboratory.
D000485:Allergens / Q000008:administration & dosage; D000818:Animals; D003594:Cytoplasmic Granules; D004195:Disease Models, Animal; D004306:Dose-Response Relationship, Immunologic; D005260:Female; D006967:Hypersensitivity / Q000276:immunology*; D007073:Immunoglobulin E / Q000096:biosynthesis; D007074:Immunoglobulin G / Q000096:biosynthesis; D007279:Injections, Subcutaneous; D008407:Mast Cells / Q000276:immunology; D051379:Mice; D010936:Plant Extracts / Q000276:immunology*; D010947:Plants, Toxic; D014026:Nicotiana
D000485:Allergens; D007074:Immunoglobulin G; D010936:Plant Extracts; D007073:Immunoglobulin E