title: [Influencing of the thyroid hormone system by long-term treatment with 5-5 diphenylhydantion in children and adolescens (author's transl)].
abstract: In the context of anticonvulsive maintenance therapy in epileptic children and adolescents, 5-5-diphenylhydantoin leads to a statistically significant decrease in total thyroxin (T4), protein-bound iodine (PBJ) and free thyroxin (FT4). The consequences of DPH therapy are based on the direct and indirect influence of DPH on the thyroid hormone system. DPH competitively pushes the T4 out of its plasma-protein bond. The lowering of T4, PBJ and finally also FT4 can be traced back to an indirect influence of DPH which consists of an increase in T4 metabolism in the liver by the DPH-induced enzyme. The possibility of a direct effect of DPH on the hypothalamus was discussed.
mesh_terms: D000293:Adolescent; D002648:Child; D004827:Epilepsy / Q000188:drug therapy; D005260:Female; D006801:Humans; D007031:Hypothalamus / Q000187:drug effects; D007455:Iodine / Q000097:blood; D008099:Liver / Q000187:drug effects / Q000378:metabolism; D008297:Male; D010672:Phenytoin / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D011485:Protein Binding; D013961:Thyroid Gland / Q000187:drug effects*; D013974:Thyroxine / Q000097:blood* / Q000378:metabolism; D013997:Time Factors
chemical_list: D010672:Phenytoin; D007455:Iodine; D013974:Thyroxine
vernacular_title: Die Beeinflussung des Schilddrüsenhormonsystems durch die Langzeitbehandlung mit 5,5-Diphenylhydantoin bei Kinder und Jugendlichen