Effect of zinc administration on the growth of L1210 and BW5147 tumors in mice.
Aqueous zinc acetate injected ip prevented tumor growth in 50-70% of BDF male mice previously inoculated ip with L1210 leukemia cells. However, aqueous zinc acetate injected sc did not prevent tumor growth in AKR/J mice inoculated im with BW5147 lymphatic leukemia cells. In the latter mice, only a small but statistically significant increase in mean survival was noted.
D000818:Animals; D002455:Cell Division / Q000187:drug effects; D007939:Leukemia L1210 / Q000188:drug therapy*; D007942:Leukemia, Experimental / Q000188:drug therapy; D007945:Leukemia, Lymphoid / Q000188:drug therapy*; D008297:Male; D051379:Mice; D008806:Mice, Inbred AKR; D008811:Mice, Inbred DBA; D015032:Zinc / Q000008:administration & dosage / Q000627:therapeutic use*
D015032:Zinc