The effect of nandrolone, an anabolic steroid on putrescine metabolism in the mouse.
1 The catabolism of injected 14 C-putrescine was studied in mice treated with nandrolone phenpropionate, an anabolic steroid. 2 The putrescine was rapidly metabolized; almost 50% of the injected radioactivity was recovered within 2 h as 14 CO2 in the expired air. 3 Considerable amounts of radioactive gamma-aminobutyric acid (GABA) and an unidentified compound were found in the kidney and in the urine in addition to radioactive putrescine, spermidine and spermine both in controls and nandrolone-treated mice. 4 Nandrolone elevated the concentration of endogenous putrescine in the kidney and urine, eightfold and twentyfold, respectively, and the concentrations of spermidine and spermine were also increased 5 after the injection of 14C-putrescine the incorporation of 14C into spermidine was significantly increased in the kidney of mice receiving nandrolone.
D000818:Animals; D002245:Carbon Dioxide / Q000378:metabolism; D007668:Kidney / Q000378:metabolism; D051379:Mice; D009277:Nandrolone / Q000494:pharmacology*; D011700:Putrescine / Q000378:metabolism* / Q000652:urine; D013095:Spermidine / Q000378:metabolism / Q000652:urine; D013096:Spermine / Q000378:metabolism / Q000652:urine; D013997:Time Factors
D002245:Carbon Dioxide; D013096:Spermine; D009277:Nandrolone; D013095:Spermidine; D011700:Putrescine