title: Circulatory, respiratory and acid-base balance changes produced by anesthetics in the rat.
abstract: The effects of several anesthetics on some cardiovascular, respiratory and metabolic responses were studied in the rat. Drugs were given by the intraperitoneal route and observations were made during a period of three hours after the injection of the agent. Results were compared with normal values obtained from unanesthetized animals. The most striking findings were: urethane produced a metabolic acidosis; chloralose increased heart rate, morphine-chloralose mixture produced a sustained hypoxia. None of these agents evoked arrhythmias in the rat. Effects of the anesthesia should be taken into account in the evaluation of drugs in anesthetized rats.
mesh_terms: D000136:Acid-Base Equilibrium / Q000187:drug effects*; D000777:Anesthetics / Q000494:pharmacology*; D000818:Animals; D001775:Blood Circulation / Q000187:drug effects*; D006439:Hemodynamics / Q000187:drug effects; D051381:Rats; D012119:Respiration / Q000187:drug effects*
chemical_list: D000777:Anesthetics