title: [Use of ADT-toxoid with decreased antigen content for the immunization against diphtheria and tetanus of children with contraindications to the inoculation of APDT vaccine. I. Revaccination of children with allergic reactivity].
abstract: A single inculation of ADP-toxoid with diminished antigen content (5 Lf of diphtheria and 5 BU of tetanus components) for diphtheria and tetanus revaccination of children aged from 1 to 11 years with allergic reactivity provided a marked immunological efficacy with an insignificant reactogenicity. The revaccinating effect was also marked in case of a prolonged lapse of time--up to 10 years (observations period) from the last vaccination. Children with allergic reactivity with contraindications to the administration of APDT vaccine and APDT vaccine and ADT-toxoid of conventional composition can be effectively revaccinated with ADT-toxoid with decreased antigen content on condition of careful clinical observation.
mesh_terms: D001428:Bacterial Vaccines; D002648:Child; D002675:Child, Preschool; D004165:Diphtheria / Q000517:prevention & control*; D004168:Diphtheria Toxoid; D006801:Humans; D006967:Hypersensitivity / Q000517:prevention & control; D007117:Immunization, Secondary; D007223:Infant; D013742:Tetanus / Q000517:prevention & control*; D013745:Tetanus Toxoid
chemical_list: D001428:Bacterial Vaccines; D004168:Diphtheria Toxoid; D013745:Tetanus Toxoid
vernacular_title: Primenenie ADS-anatoksina s umen'shennym soderzhaniem antigenov dlia immunizatsii deteĭ, imeiushchikh protivipokazaniia k vvedeniiu AKDS-vaktsiny. Soobshchenie I. Revaktsinatsiia deteĭ s allergicheskoĭ reaktivnost'iu