Phaeochromocytoma with myocarditis managed with alpha-methyl-p-tyrosine.
A case of bilateral phaeochromocytoma with catecholamine-induced myocarditis is described. The two operations needed allowed comparison of the use of alpha-methyl-p-tyrosine alone and in conjunction with adrenergic blocks in the management of the patient. The combination of both drugs was particularly successful in the relief of symptoms and reduction of catecholamine metabolism as monitored by 4-hydroxy-3-methoxymandelic acid (HMMA) excretion. As myocarditis is a potentially fatal complication, further investigation of the combined use of alpha-methyl-p-tyrosine and adrenergic blocking drugs is suggested in the pre-operative management of patients with phaeochromocytoma.
D000310:Adrenal Gland Neoplasms / Q000150:complications* / Q000188:drug therapy; D000328:Adult; D005260:Female; D006801:Humans; D008781:Methyltyrosines / Q000627:therapeutic use*; D009205:Myocarditis / Q000188:drug therapy / Q000209:etiology*; D010673:Pheochromocytoma / Q000150:complications* / Q000188:drug therapy; D013565:Sympatholytics / Q000627:therapeutic use
D008781:Methyltyrosines; D013565:Sympatholytics