Effects of penicillamine on the contents of B6 vitamers of the mouse brain.
The contents of B6 vitamers were measured in the brains of mice treated with DL- and D-PeA. When a single convulsant dose of DL-PeA was injected, PLP content was decreased, being accompanied with production of PLP-thiazolidine. The effect of DL-PeA on PLP content was evident far before the occurrence of the convulsions. The administration of PN together with DL-PeA prevented the onset of seizures and lessened the effect of DL-PeA on PLP content. The same amount of D-PeA did not invoke seizures, but caused a small but significant decrease in PLP content.
D000818:Animals; D001921:Brain / Q000378:metabolism*; D051379:Mice; D010396:Penicillamine / Q000494:pharmacology*; D011730:Pyridoxal / Q000378:metabolism; D011732:Pyridoxal Phosphate / Q000378:metabolism; D011733:Pyridoxamine / Q000378:metabolism; D011736:Pyridoxine / Q000378:metabolism* / Q000494:pharmacology; D013843:Thiazines / Q000378:metabolism; D013844:Thiazoles / Q000378:metabolism
D013843:Thiazines; D013844:Thiazoles; D011730:Pyridoxal; D011732:Pyridoxal Phosphate; D011733:Pyridoxamine; D010396:Penicillamine; D011736:Pyridoxine