Metabolic recovery of articular cartilage after intra-articular injections of glucocorticoid.
The recovery of adult rabbit articular cartilage after nine weekly intra-articular injections of hydrocortisone acetate was investigated using biochemical, autoradiographic, and tracer methods. After the cessation of steroid injections, the rates of synthesis of proteoglycans and collagen increased by up to 900 per cent. The increase occurred because of accelerated metabolism of existing cells and an increase (caused by mitosis) in the number of functioning chondrocytes. The proteoglycan concentration only returned to normal values after six months.
D000818:Animals; D002357:Cartilage Diseases / Q000139:chemically induced / Q000378:metabolism*; D002358:Cartilage, Articular / Q000032:analysis / Q000187:drug effects / Q000378:metabolism*; D003094:Collagen / Q000096:biosynthesis*; D004247:DNA / Q000032:analysis; D004195:Disease Models, Animal; D006595:Hexosamines / Q000032:analysis; D006854:Hydrocortisone / Q000008:administration & dosage / Q000494:pharmacology*; D006909:Hydroxyproline / Q000378:metabolism; D007270:Injections, Intra-Articular; D007719:Knee Joint; D011509:Proteoglycans / Q000096:biosynthesis*; D011817:Rabbits
D006595:Hexosamines; D011509:Proteoglycans; D003094:Collagen; D004247:DNA; D006909:Hydroxyproline; D006854:Hydrocortisone