Chemical and morphological studies of rat myocardium after application of a necrogenic dose of isoproterenol.
In male Wistar rats myocardial necroses were produced by application of 80 mg of isoproterenol per kg of body weight. 2 and 48 hours after isoproterenol administration the Na+ and K+ contents were determined. At these times Na+ presented increases of 128 and 83% respectively, and K+ of 13 and 8% respectively as compared to the controls. These results were related to the morphological changes appearing at the same time, and were discussed with references to the literature. Taking edema and vasodilatation into account, the degree of cell damage can be estimated on the basis of the chemical data available.
D000818:Animals; D007545:Isoproterenol; D008297:Male; D009206:Myocardium / Q000032:analysis / Q000473:pathology*; D009336:Necrosis; D011188:Potassium / Q000032:analysis; D051381:Rats; D012964:Sodium / Q000032:analysis; D013997:Time Factors
D012964:Sodium; D007545:Isoproterenol; D011188:Potassium