Termination of abnormal intrauterine pregnancies with intramuscular administration of dihomo 15 methyl prostaglandin F 2alpha.
A synthetic compound, 2a, 2b dihomo 15 (S) 15 methyl prostaglandin F 2 alpha methyl ester given 8-hourly by intramuscular injection was used to terminate pregnancies in 72 patients with a missed abortion, intrauterine fetal death, molar or anencephalic pregnancies. Treatment was successful in all cases. A 4 mg dose of loperamide given orally at 15 to 30 minutes before the injection of prostaglandin analogue prevented diarrhoea as a side effect.
D000030:Abortion, Missed / Q000188:drug therapy; D000032:Abortion, Therapeutic; D000757:Anencephaly / Q000188:drug therapy; D003967:Diarrhea / Q000139:chemically induced / Q000188:drug therapy; D005260:Female; D005313:Fetal Death / Q000188:drug therapy; D006801:Humans; D006828:Hydatidiform Mole / Q000188:drug therapy; D008139:Loperamide / Q000627:therapeutic use; D011247:Pregnancy; D011248:Pregnancy Complications / Q000188:drug therapy*; D011460:Prostaglandins F / Q000627:therapeutic use; D011465:Prostaglandins, Synthetic / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D014594:Uterine Neoplasms / Q000188:drug therapy
D011460:Prostaglandins F; D011465:Prostaglandins, Synthetic; D008139:Loperamide