[Use of glucose-6-phosphate dehydrogenase and transketolase for characterization of pathologic processes in the myocardium in rheumatism].
In patients with active rheumatism the activity of the key enzymes of the pentose cycle -- glucoso-6-phosphatedehydrogenase and transketolase -- increases in the erythrocytes of the peripheral blood parallel with the severity of the inflammatory lesion of the heart. In patients with distrophic changes in the myocardium without concomitant carditis the level of glucoso-6-phosphatedehydrogenase did not change significantly, while the content of transketolase decreased considerably. Antirheumatic therapy helping to reduce the inflammatory reactions in the heart results in a reduction of the level of pentose cycle enzymes. The study of the ratio between glucoso-6-phosphatedehydrogenase and transketolase may prove valuable for an approximate evaluation of the predominance of inflammatory or dystrophic processes in the cardiac muscle.
D000293:Adolescent; D000328:Adult; D004796:Clinical Enzyme Tests; D004912:Erythrocytes / Q000201:enzymology*; D005260:Female; D005954:Glucosephosphate Dehydrogenase / Q000097:blood*; D006801:Humans; D008297:Male; D008875:Middle Aged; D012214:Rheumatic Heart Disease / Q000097:blood* / Q000188:drug therapy; D013831:Thiamine / Q000627:therapeutic use; D013835:Thiamine Pyrophosphate / Q000627:therapeutic use; D014174:Transketolase / Q000097:blood*
D005954:Glucosephosphate Dehydrogenase; D014174:Transketolase; D013835:Thiamine Pyrophosphate; D013831:Thiamine
Ispol'zovanie gliukozo-6-fosfatdegidrogenazy i transketolazy dlia kharakteristiki patologicheskikh protsessov v serdechnoĭ myshtse pri revmatizme