Effect of intrajejunal fat on meal-stimulated acid and gastrin secretion in man.
The effect of intrajejunal fat infusion on meal-stimulated gastric acid and gastrin secretion was studied in 8 healthy volunteers. Intrajejunal fat significantly reduced the acid response to a meal, measured by intragastric titration, as compared to intrajejunal infusion of saline. While serum gastrin concentrations rose from fasting levels to a constant plateau after the meal when saline was infused, fat infusion resulted in a transitory decrease in serum gastrin concentration followed by a significant increase. It is concluded that inhibition of gastrin release only plays a minor role, if any, in the observed fat-induced jejuanl inhibition of meal-stimulated acid secretion.
D000328:Adult; D005223:Fats / Q000008:administration & dosage / Q000494:pharmacology*; D005260:Female; D005502:Food; D005750:Gastric Juice / Q000378:metabolism*; D005753:Gastric Mucosa / Q000378:metabolism*; D005755:Gastrins / Q000097:blood / Q000378:metabolism*; D006801:Humans; D007267:Injections; D007583:Jejunum; D008297:Male; D011708:Pylorus / Q000378:metabolism*; D012636:Secretory Rate / Q000187:drug effects
D005223:Fats; D005755:Gastrins