Simultaneous estimation of four plasma androgens before and after dynamic tests in women with hirsutism: correlation with long-term therapy.
Concentrations of testosterone, delta4-androstenedione, dihydrotestosterone and delta5-androstenediol were measured in 12 patients affected by hirsutism associated with menstrual disorders. Testosterone was elevated in 9 cases, in whom high levels of delta4-androstenedione and dihydrotestosterone was found, and normal in 3 cases, 2 of which presented high values of dihydrotestosterone and one high levels of delta5-androstenediol. In some hirsute females therefore, other androgens, such as dihydrotestosterone and delta5-androstenediol, play a role in the pathogenesis of hirsutism. Dexamethasone and estrogen progestin combinations were administered for dynamic tests, and results in most cases provided useful information in the selection of suitable long-term therapy.
D000293:Adolescent; D000328:Adult; D000728:Androgens / Q000097:blood*; D000734:Androstenediols / Q000097:blood; D000735:Androstenedione / Q000097:blood; D003907:Dexamethasone / Q000627:therapeutic use; D013196:Dihydrotestosterone / Q000097:blood; D045166:Estradiol Congeners / Q000627:therapeutic use; D005260:Female; D006628:Hirsutism / Q000097:blood* / Q000188:drug therapy; D006801:Humans; D008297:Male; D008875:Middle Aged; D045167:Progesterone Congeners / Q000627:therapeutic use; D012737:Sex Factors; D013739:Testosterone / Q000097:blood
D000728:Androgens; D000734:Androstenediols; D045166:Estradiol Congeners; D045167:Progesterone Congeners; D013196:Dihydrotestosterone; D013739:Testosterone; D000735:Androstenedione; D003907:Dexamethasone