Chemical constituents of Gentianaceae XIX: CNS-depressant effects of swertiamarin.
CNS activity of swertiamarin, a secoiridoid glucoside from Swertia chirata, was evaluated. An apparent anomaly, associated with the unanticipated finding that the alcoholic extracts (excluding mangiferin) of S. chirata significantly reversed the mangiferin-induced CNS-stimulating effects in albino mice and rats, was resolved. The results indicate that swertiamarin and mangiferin antagonize each other in vivo and thereby reverse their CNS effects.
D000661:Amphetamine / Q000633:toxicity; D000818:Animals; D000927:Anticonvulsants; D001522:Behavior, Animal / Q000187:drug effects; D002490:Central Nervous System / Q000187:drug effects*; D003864:Depression, Chemical; D004347:Drug Interactions; D005960:Glucosides / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D006027:Glycosides / Q000494:pharmacology*; D006591:Hexobarbital / Q000494:pharmacology; D057888:Iridoid Glucosides; D051379:Mice; D009020:Morphine / Q000494:pharmacology; D009048:Motor Skills / Q000187:drug effects; D010672:Phenytoin / Q000494:pharmacology; D010936:Plant Extracts / Q000494:pharmacology*; D010946:Plants, Medicinal / Q000032:analysis*; D011714:Pyrans / Q000494:pharmacology*; D011753:Pyrones / Q000494:pharmacology*; D051381:Rats; D012890:Sleep / Q000187:drug effects; D014966:Xanthenes / Q000037:antagonists & inhibitors; D044004:Xanthones
D000927:Anticonvulsants; D005960:Glucosides; D006027:Glycosides; D057888:Iridoid Glucosides; D010936:Plant Extracts; D011714:Pyrans; D011753:Pyrones; D014966:Xanthenes; D044004:Xanthones; C013592:mangiferin; C013270:swertiamarin; D010672:Phenytoin; D009020:Morphine; D006591:Hexobarbital; D000661:Amphetamine