Device for constant Sc infusion of methotrexate: plasma results in mice.
An infusion device is described which permits sc infusion of methotrexate into mice at a constant rate. Physical characteristics of devices ranging in size from 0.27-mm internal diameter X 15 mm long to 1.95-mm internal diameter X 2 mm long are described. Plateau plasma concentrations of methotrexate (1 X 10(-8) M to 1 X 10(-5) M) achieved from infusion rates varying over three orders of magnitude (less than 1- greater than 100 mug/hour) are presented. These data are evaluated in terms of the known toxic effects and pharmacokinetic behavior of this drug.
D000818:Animals; D004058:Diffusion; D007263:Infusions, Parenteral / Q000379:methods*; D007700:Kinetics; D008727:Methotrexate / Q000008:administration & dosage* / Q000097:blood; D051379:Mice
D008727:Methotrexate