title: Schizophrenia: a postulated animal model.
abstract: Studies dealing with psychiatric concomitants of epilepsy and penetrating brain injury suggest that phenomena seen may be based on the side of injury. A separate, growing literature has begun to relate shizophrenia directly to problems of inter-hemispheric relation. Experimental work on animal rotation also deals with aspects of cerebral asymmetry. The chemical and anatomic systems manipulated in the animal work are the same as those postulated to be central to a biological understanding of schizophrenia. How these seemingly disparate subject matters may merge and point to a plausible animal model for the schizophrenias is the hypothesis presented in this paper.
mesh_terms: D000661:Amphetamine / Q000494:pharmacology; D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects / Q000502:physiology; D001930:Brain Injuries / Q000150:complications; D004195:Disease Models, Animal; D004833:Epilepsy, Temporal Lobe / Q000150:complications; D007839:Functional Laterality; D006801:Humans; D001523:Mental Disorders / Q000209:etiology; D011618:Psychotic Disorders / Q000150:complications; D051381:Rats; D012559:Schizophrenia / Q000503:physiopathology*; D013687:Telencephalon / Q000187:drug effects / Q000502:physiology
chemical_list: D000661:Amphetamine