Simultaneous determination of methylated barbiturates and other anticonvulsant drugs by high-resolution gas chromatography.
Several barbiturates and other anticonvulsant drugs can be analyzed simultaneously as dimethylated derivatives by high-resolution gas chromatography with a solid flash methylation injector. Quantitative determinations were performed on test serum during a quality control scheme. The sensitivity (+/- 0.1 mug/ml) and the accuracy are compatible with the measurement of therapeutic levels of barbiturates. The advantages of the method are discussed.
D000927:Anticonvulsants / Q000097:blood*; D001463:Barbiturates / Q000097:blood* / Q000592:standards; D002849:Chromatography, Gas / Q000379:methods*; D008722:Methods; D008832:Microchemistry; D014297:Trimethylsilyl Compounds / Q000032:analysis
D000927:Anticonvulsants; D001463:Barbiturates; D014297:Trimethylsilyl Compounds