[Correlative analysis of chemical structure - biological activity using Hansch's method: principles and development of the method].
The basic principles and developments on which the Hansch multiple parameter approach depends are described. A correlation analysis on the antibacterial activity of 2-Y-4-(X-phenyl)-3H-1,5-benzodiazepines is discussed. The use of indicator varioables is shown to greatly increase one's ability to formulate quantitative structure-activity relationships. This approach allows one to carry out objective studies of massive amounts of chemical and biological data.
D001419:Bacteria / Q000187:drug effects; D001569:Benzodiazepines / Q000494:pharmacology; D008722:Methods; D013329:Structure-Activity Relationship
D001569:Benzodiazepines
Analisi correlativa struttura chimica-attivita biologica secondo Hansch: Principi ed evoluzione