[Comparative kinetics of oxytetracycline and oxyglucocycline cotent in tissues of the ENT organs].
The kinetics of oxytetracycline and oxyglucocycline levels (calculated for oxytetracycline) was studied on 80 patients with chronic inflammatory diseases of the upper respiratory organs, the antibiotics being administered intramuscularly. After a single injection of oxytetrachcline hydrochloride in a dose of 1500 Units/kg body weight its levels in the blood serum and certain tissues of the ENT organs were rather low. When the dose was 3000 Units/kg the maximum antibiotic level in the blood level reached 1 Unit/ml. The drug was detected in the bacteriostatic concentrations in the blood serum and tissues within 12 hours. When the dose of oxyglucocycline was 1500 Units/kg the rate of its absorption was 4 times higher than that of oxytetracycline absorption. However, the character of its distribution in the blood and tissues of the ENT organs did not differ from distribution of oxytetracycline as dependent on the duration of the injection period. The both pharmaceutical forms had a tendency to some retention of the drugs in the tissues of the palatine tonsils. Because of better absorption and retention in the tonsils tissue oxyglucocycline may be recommended for therapy of inflammatory processes in the lymphadenoid apparatus of the pharynx.
D001702:Biopharmaceutics; D004305:Dose-Response Relationship, Drug; D006801:Humans; D007273:Injections, Intramuscular; D007700:Kinetics; D009297:Nasal Mucosa / Q000378:metabolism*; D010118:Oxytetracycline / Q000031:analogs & derivatives* / Q000378:metabolism*; D014066:Palatine Tonsil / Q000378:metabolism*; D010256:Paranasal Sinuses / Q000378:metabolism; D010612:Pharyngitis / Q000188:drug therapy; D013997:Time Factors
C012471:oxyglucocycline; D010118:Oxytetracycline
Sravnitel'naia kinetika soderzhaniia oksitetratsiklina i oksigliukotsiklina v nekotorykh tkaniakh LORorganov