Plasma prolactin response to L-dopa TRH and metaclopramide in thyrotoxicosis.
The plasma PRL repsonse to synthetic TRH, L-dopa and metaclopramide was evaluated in patients with thyrotoxicosis. A PRL response similar to thtaclopramide,while no PRL response was observed after TRH. When the TRH-test was repeated after treatment, all patients showed a normal increment in plasma PRL. This data suggests that, in thyrotoxicosis, PRl response to TRH only is impaired, but PRL can be suppressed by L-dopa or released by metaclopramide notwithstanding the elevated values of thyroid hormone levels.
D005260:Female; D006801:Humans; D006980:Hyperthyroidism / Q000097:blood / Q000503:physiopathology*; D007275:Injections, Intravenous; D007980:Levodopa / Q000008:administration & dosage / Q000494:pharmacology*; D008297:Male; D008787:Metoclopramide / Q000008:administration & dosage / Q000494:pharmacology*; D011342:Procainamide / Q000494:pharmacology; D011388:Prolactin / Q000097:blood / Q000378:metabolism*
D007980:Levodopa; D011388:Prolactin; D011342:Procainamide; D008787:Metoclopramide