[Effect of the cholinesterase inhibitor armin on meuromuscular synapse function of the frog sartorius muscle].
The organophosphurus inhibitor of cholinesterases armin(2-10-9--2-10-4 M) prolonged postjunction potentials and in concentration 2-10-9--2-10-7 M increased the amplitude of miniature end-plate potentials (m. e. p. p. s and quantum content of e.p.p.s. These parameters were increased again after washing. Thus, armin (2-10-9--2-10-7 M) exerts anticholinesterase effect only. In concentrations 2-10-6--2-10-4M, in addition to the anticholinesterase effect, it affects presynaptic membrane and inhibits postsynaptic membrane cholinoreceptors.
D000818:Animals; D002800:Cholinesterase Inhibitors / Q000494:pharmacology*; D003864:Depression, Chemical; D008564:Membrane Potentials / Q000187:drug effects; D009469:Neuromuscular Junction / Q000187:drug effects*; D009578:Nitrobenzenes / Q000494:pharmacology; D009943:Organophosphorus Compounds / Q000494:pharmacology*; D010721:Phosphinic Acids / Q000494:pharmacology*; D013570:Synaptic Membranes / Q000187:drug effects
D002800:Cholinesterase Inhibitors; D009578:Nitrobenzenes; D009943:Organophosphorus Compounds; D010721:Phosphinic Acids
Vliianieingibitora kholińesteraz armina na funktsii nervno-myshechnogo simapsa protniazhoï myshtsy liagushki