The influence of albumin degradation products on central action of amphetamine and pentetrazol.
Trypsin degradation products of albumin given intraperitoneally and into the brain ventricle decrease psychostimulatory effects of amphetamine as evaluated by Lat's test and stereotypy. Albumin degradation products obtained by trypsin and leukocyte digestion increased the convulsant effects of pentetrazol. These effects are possibly connected with a neurohormonal background in the central nervous system.
D000661:Amphetamine / Q000494:pharmacology*; D000818:Animals; D001921:Brain / Q000187:drug effects*; D006801:Humans; D008297:Male; D009043:Motor Activity / Q000187:drug effects; D010433:Pentylenetetrazole / Q000494:pharmacology*; D051381:Rats; D012640:Seizures / Q000139:chemically induced; D012709:Serum Albumin / Q000494:pharmacology*; D013239:Stereotyped Behavior / Q000187:drug effects
D012709:Serum Albumin; D000661:Amphetamine; D010433:Pentylenetetrazole