[Glucocorticoids receptors in rat testis: their role in Leydig cells specific function and DNA synthesis (author's transl)].
Rat testicular cytosol binds specificity dexamethasone (KD = 5 X 10(=9)M). After incubation of testicular slices with 3H-dexamethasone, at 30 degrees C for 2 hours most of the intracellular radioactivity is found inthe nuclei. Administration of h CG at pharmacological doses for three days to male rat during puberty increases plasma testosterone levels and 3H-thymidine incorporation into testicular DNA. Simultaneous administration of dexamethasone partially blocks both effects of hCG. These results suggest that interaction of glucocorticoïds with specific receptors controls both the specific function and the cells multiplication of rat Leydig cells.
D000818:Animals; D004247:DNA / Q000096:biosynthesis*; D007985:Leydig Cells / Q000378:metabolism*; D008297:Male; D051381:Rats; D011965:Receptors, Glucocorticoid; D011987:Receptors, Steroid; D013737:Testis / Q000378:metabolism; D013739:Testosterone / Q000378:metabolism; D013936:Thymidine / Q000378:metabolism
D011965:Receptors, Glucocorticoid; D011987:Receptors, Steroid; D013739:Testosterone; D004247:DNA; D013936:Thymidine
RECEPTEURS DE GLUCOCORTICOIDES DANS LE TESTICULE DE RAT