Differential susceptibility of L cells in the exponential and stationary phases to cadmium chloride.
Comparative studies of the cellular toxicity and uptake of cadmium in L cells in the exponential and stationary phases were done. The LD50 of cadmium chloride to L cells in the exponential and stationary phases was 5.5 and 30.5 muM respectively and the cadmium content of L cells exposed to 5.4 muM cadmium chloride for 3.5 hr in the exponential and stationary phases was 0.123 and 0.065 mug/10(6) cells, respectively. These results suggest that the higher susceptibility of cells in the exponential phase to cadmium may be caused by an increased permeability of the cell membrane to cadmium.
D000818:Animals; D002104:Cadmium / Q000378:metabolism / Q000494:pharmacology*; D002478:Cells, Cultured; D007739:L Cells / Q000166:cytology / Q000187:drug effects* / Q000378:metabolism; D007928:Lethal Dose 50; D051379:Mice; D013997:Time Factors
D002104:Cadmium