title: Measurements of oxygen tension from the canine gastric mucosa under the influence of vasoactive and acid stimulating agents and following vagotomy. Implications on the pathophysiology of peptic ulceration.
abstract: By the use of a multiwire platinum electrode mucosal tissue pO2 from the canine gastric antrum is continuously recorded. Injection of norepinephrine causes a short, steep fall of mucosal pO2, naftidrofuryl elevates mucosal pO2 for several minutes in spite of reduced arterial blood pressure, pentagastrin produces a biphasic response, a temporary rise of mucosal pO2 is followed by a longer lasting decrease, vagotomy causes a considerable and more persistent drop of mucosal pO2. These experimental findings are discussed in their possible relations to the clinical problem of ulcer formation and therapy of gastroduodenal bleeding.
mesh_terms: D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D004285:Dogs; D005260:Female; D005663:Furans / Q000494:pharmacology*; D005753:Gastric Mucosa / Q000503:physiopathology*; D008297:Male; D009257:Nafronyl / Q000494:pharmacology*; D009638:Norepinephrine / Q000494:pharmacology*; D010101:Oxygen Consumption / Q000187:drug effects*; D010418:Pentagastrin / Q000494:pharmacology*; D010437:Peptic Ulcer / Q000209:etiology / Q000503:physiopathology*; D011183:Postoperative Complications / Q000503:physiopathology; D014628:Vagotomy
chemical_list: D005663:Furans; D009257:Nafronyl; D010418:Pentagastrin; D009638:Norepinephrine