title: Supersensitivity of cortical neurones of the rat to acetylcholine and L-glutamate following chronic morphine treatment.
abstract: the effect of microelectrophoretically applied L-glutamate and acetylcholine on discharge activity of cortical neurones was studied in naive and in morphine-tolerant/dependent rats. The thresholds for increase in discharge activity elicited by these 2 putative neurotransmitters were 3 times lower in the tolerant/dependent rats than in the naive rats, indicating the development of supersensitivity.
mesh_terms: D000109:Acetylcholine / Q000494:pharmacology*; D000818:Animals; D002540:Cerebral Cortex / Q000187:drug effects* / Q000502:physiology; D004357:Drug Synergism; D004361:Drug Tolerance; D004594:Electrophysiology; D005971:Glutamates / Q000494:pharmacology*; D006801:Humans; D008297:Male; D009020:Morphine / Q000494:pharmacology*; D009021:Morphine Dependence / Q000503:physiopathology; D009474:Neurons / Q000187:drug effects* / Q000502:physiology; D051381:Rats
chemical_list: D005971:Glutamates; D009020:Morphine; D000109:Acetylcholine