title: Mortality and some biochemical changes in mink (Mustela vison) given sublethal doses of aflatoxin each day.
abstract: Two feeding trials were done to study the susceptibility of mink (Mustela vison) to multiple sublethal doses of aflatoxins. In the 1st trial, twenty 3-month-old male mink were divided equally among groups. Each mink in groups 1, 2, 3, and 4 was given a meatball daily that contained 15, 30, 45, or 0 mug of aflatoxins (B1:G1, 40:60), respectively. All mink in group 3 died between the 25th and the 30th days of the feeding trial. Each mink had ingested 1,035 to 1,480 mug of aflatoxins. Four of the mink in group 2 died almost as soon as did mink in group 3. Four mink in group 1 died between 40 and 59 days after the start of the feeding trial. Generally, a marked increase in plasma cholesterol and alkaline phosphatase activity appeared before mink died. The liver from animals that died of aflatoxicosis showed prominent pathologic changes which included hemorrhages and appearance of pink yellow spots. Histopathologic examination of liver from dead mink revealed fatty infiltration, bile duct proliferation, bile stasis, pseudotubular  formation, congestion, and fibrosis. The feeding trial was repeated with 20 mink (8 males and 12 females) that were 1.5 to 2 years old. In this instance, 0, 20, 40, and 60 mug of aflatoxins were administered each day. All treated animals, except 1, were dead within 37 days after the experiment started. The survivor was given the lowest dosage of toxins and died after 52 days by which time 960 mug of aflatoxins were consumed. Plasma cholesterol content and alkaline phosphatase activity generally were similar to those observed in younger mink of the 1st feeding trial.
mesh_terms: D000348:Aflatoxins / Q000008:administration & dosage / Q000633:toxicity*; D000469:Alkaline Phosphatase / Q000097:blood; D000818:Animals; D002784:Cholesterol / Q000097:blood; D005260:Female; D008099:Liver / Q000473:pathology; D008107:Liver Diseases / Q000473:pathology / Q000662:veterinary; D008297:Male; D008907:Mink
chemical_list: D000348:Aflatoxins; D002784:Cholesterol; D000469:Alkaline Phosphatase