Immunological findings in a case of Cogan's syndrome.
The immune system of a case of Cogan's syndrome was investigated. A transient depression of the cell-mediated immunity was found. Thus, during the acute stage of the disease, there was a depression of the cutaneous delayed hypersensitivity reaction to PPD and a decrease in the number of T cells. There were also signs of complement consumption. A possible pathogenesis based on immune complexes due to a preceding viral infection is discussed.
D000208:Acute Disease; D000293:Adolescent; D003176:Complement C3 / Q000032:analysis; D003181:Complement C4 / Q000032:analysis; D003168:Complement Fixation Tests; D003165:Complement System Proteins / Q000032:analysis; D003638:Deafness; D005260:Female; D006801:Humans; D006968:Hypersensitivity, Delayed; D007111:Immunity, Cellular; D007136:Immunoglobulins / Q000032:analysis; D007634:Keratitis / Q000276:immunology*; D007759:Labyrinth Diseases / Q000276:immunology*; D008213:Lymphocyte Activation; D008214:Lymphocytes / Q000276:immunology; D012882:Skin Tests; D013577:Syndrome; D014777:Virus Diseases / Q000276:immunology
D003176:Complement C3; D003181:Complement C4; D007136:Immunoglobulins; D003165:Complement System Proteins