[Effect of preparations of messenger RNA from the spleens of immunized rats on antibody synthesis in rat lymphosarcoma].
Messenger RNA was isolated from spleen polysomes of rats immunized with sheep red cells, two methods being employed: a sorption of mRNA on on membrane filters, and poly(U)-cellulose affinity chromatography. The rat transplantable lymphosarcoma cells treated with this RNA started hemolysine synthesis which persisted throughout many cell generations in transplantation of the tumor. The probability is discussed of m-RNA not only functioning as a template for antibody synthesis but also deblocating appropriate genes in recipient cells.
D000818:Animals; D006460:Hemolysin Proteins / Q000096:biosynthesis*; D008228:Lymphoma, Non-Hodgkin / Q000276:immunology*; D012333:RNA, Messenger / Q000302:isolation & purification / Q000494:pharmacology*; D051381:Rats; D012513:Sarcoma, Experimental / Q000276:immunology; D013154:Spleen / Q000032:analysis* / Q000276:immunology
D006460:Hemolysin Proteins; D012333:RNA, Messenger
Vliianie preparatov informatsionnykh RNK selezenki immunizirovannykh krys na sintez antitel v krysinoĭ limfosarkome