title: Early experimental myocardial infarction. Evaluation of histologic criteria and comparison with biochemical and electrocardiographic measurements.
abstract: Light microscopical criteria of early experimental myocardial infarction were compared with biochemical changes in glycogen content and the tissue K+/Na+ ratio in 19 mongrel dogs. Five sham-operated dogs served as controls, and seven of the 14 dogs with experimentally induced infarcts received infusions of glucose, insulin, and potassium (GIK). Infarcts were diagnosed by a scoring system based on edema formation, congestion, waviness of myofibers, myofibrillar degeneration, polymorphonucleosis, glycogen depletion, and fuchsinorrhagia. Significant histologic scores were associated with tissue K+/Na+ ratios of less than 1.2, with 30% depletion of biochemical glycogen, and with epicardial ST-segment elevation. Progression of the infarction zone to involve the surrounding border zone was prevented by GIK infusions. Routine light microscopy used in conjunction with tissue K+/Na+ ratios enabled early infarction to be diagnosed with a high degree of accuracy.
mesh_terms: D000818:Animals; D001706:Biopsy; D004285:Dogs; D004562:Electrocardiography; D005947:Glucose / Q000627:therapeutic use; D006003:Glycogen / Q000378:metabolism; D006801:Humans; D007328:Insulin / Q000627:therapeutic use; D009203:Myocardial Infarction / Q000378:metabolism / Q000473:pathology* / Q000517:prevention & control; D011188:Potassium / Q000378:metabolism / Q000627:therapeutic use; D012964:Sodium / Q000378:metabolism
chemical_list: D007328:Insulin; D006003:Glycogen; D012964:Sodium; D005947:Glucose; D011188:Potassium