The inhibitory effect of IgM RF on the release of lysosomal substances.
Isolated IgM RF inhibited the IgG-induced release of lysosomal substances, measured as 'large molecular size vitamin B12-binding protein' (LBP) and beta-glucronidase, from separated human granulocytes. The effect was most marked when cytochalasin B was added to the experimental system. The results indicate that the RFs interact with the granulocyte binding region of IgG.
D003571:Cytochalasin B / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D005966:Glucuronidase / Q000378:metabolism*; D006098:Granulocytes / Q000378:metabolism; D006358:Hot Temperature; D006801:Humans; D007074:Immunoglobulin G / Q000378:metabolism; D007075:Immunoglobulin M / Q000494:pharmacology*; D008247:Lysosomes / Q000378:metabolism*; D008970:Molecular Weight; D011485:Protein Binding / Q000187:drug effects; D012217:Rheumatoid Factor / Q000008:administration & dosage / Q000494:pharmacology*; D014805:Vitamin B 12 / Q000378:metabolism*
D007074:Immunoglobulin G; D007075:Immunoglobulin M; D003571:Cytochalasin B; D012217:Rheumatoid Factor; D005966:Glucuronidase; D014805:Vitamin B 12