[Serum humoral factors--cause of the altered physiologic state of peripheral blood lymphocytes in schizophrenic patients].
Statistically significant correlations were revealed between the following: the percentage content in the lymphocyte cultures of patients suffering from schizophrenia of cells responding to stimulation with phytohemagglutinin (PHA) by DNA synthesis, and the percentage in the white blood cell cultures of healthy donors of lymphocytes failing to respond to the PHA stimulation by the DNA synthesis as a result of cultivation of these cells in a medium containing the blood serum (20%) of schizophrenic patients. Similar correlation was revealed between the percentage content in cultures of the white blood cells of schizophrenic patients of adhesive lymphocytes and the percentage of adhesive lymphocytes in the white blood cell cultures of healthy donors in cultivation of these cells in a medium containing the blood serum (20%) of schizophrenic patients. The data obtained confirmed a supposition that the altered physiological condition of the peripheral blood lymphocytes of patients suffering from schizophrenia was caused by the factors contained in the blood serum of these patients.
D000328:Adult; D004247:DNA / Q000096:biosynthesis*; D005260:Female; D006801:Humans; D007106:Immune Sera / Q000494:pharmacology*; D037102:Lectins; D008214:Lymphocytes / Q000378:metabolism*; D008297:Male; D012559:Schizophrenia / Q000097:blood*
D007106:Immune Sera; D037102:Lectins; D004247:DNA
Gumoral'nye faktory syvorotki--prichina izmenennogo fiziologicheskogo sostaoianiia limfotsitov perifericheskoí krovi bol'nykh shizofrenieí