Effect of acute sodium or potassium depletion on plasma renin activity in haemodialysed patients.
A closed loop closed batch dialysate delivery system was used to determine whether Na or K has an action on the renin-angiotensin system apart from volume changes. Twenty-eight patients on chronic haemodialysis were studied, 12 (group I) were normotensive and 16 (group II) had poorly controlled hypertension. Acute Na depletion or repletion (delta NA), AND K loss (delta K) were induced with or without net water loss. Net electrolyte and water movement across the dialysis membrane could be precisely quantitated.
D000328:Adult; D005260:Female; D006801:Humans; D006973:Hypertension / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D011188:Potassium / Q000097:blood / Q000378:metabolism*; D006435:Renal Dialysis; D012083:Renin / Q000097:blood*; D012964:Sodium / Q000097:blood / Q000378:metabolism*
D012964:Sodium; D012083:Renin; D011188:Potassium