title: Acetate utilization by the isolated perfused guinea-pig mammary gland.
abstract: Acetate uptake by isolated perfused guinea-pig mammary glands was approximately 1.0 mg g-1 h-1 when perfusate acetate concentrations were in the physiological range (5-11 mg/100 ml plasma). At perfusate concentrations below this range (mean 3.62 mg/100 ml plasma) the uptake was not significantly different, but in one experiment in which the mean acetate concentration was 14.5 mg/100 ml plasma the uptake was markedly elevated. Radioactivity from Na (1-14C) acetate was incorporated into CO2 and milk and tissue fat, being largely present in C16 and C18 fatty acids. The guinea-pig is atypical of non-ruminants and similar to ruminants in respect of the blood concentration and mammary utilization acetate.
mesh_terms: D000085:Acetates / Q000378:metabolism*; D000818:Animals; D002245:Carbon Dioxide / Q000378:metabolism; D005227:Fatty Acids / Q000096:biosynthesis; D005260:Female; D006168:Guinea Pigs / Q000378:metabolism*; D007774:Lactation; D008055:Lipids / Q000096:biosynthesis; D008321:Mammary Glands, Animal / Q000378:metabolism*; D008892:Milk / Q000378:metabolism; D011247:Pregnancy; D013045:Species Specificity
chemical_list: D000085:Acetates; D005227:Fatty Acids; D008055:Lipids; D002245:Carbon Dioxide