title: [Facilitation of the effects of L-DOPA by alpha-methyldopa].
abstract: Alpha-methyl-DOPA increased the duration of excitation induced by L-DOPA in mice, alpha-methyl-DOPA potentiated the anticataleptogenic activity of L-DOPA in mice pretreated with reserpine or haloperidol. Alpha-methyl-DOPA given to cats 30 min prior to L-DOPA diminished the influence of L-DOPA on the blood pressure and the contraction of the nictitating membrane. When given 4 to 6 hours prior to L-DOPA alpha-methyl DOPA enhanced the reaction of the blood pressure and contraction of the nictitating membrane induced by L-DOPA or dopamine.
mesh_terms: D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D002375:Catalepsy / Q000139:chemically induced / Q000188:drug therapy; D002415:Cats; D004298:Dopamine / Q000494:pharmacology; D004347:Drug Interactions; D004359:Drug Therapy, Combination; D006220:Haloperidol / Q000494:pharmacology; D006801:Humans; D007980:Levodopa / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D008297:Male; D008750:Methyldopa / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D051379:Mice; D009541:Nictitating Membrane / Q000187:drug effects; D012110:Reserpine
chemical_list: D007980:Levodopa; D008750:Methyldopa; D012110:Reserpine; D006220:Haloperidol; D004298:Dopamine
vernacular_title: Ob usilenii éffektov L-dopa na fone alpha-metil-DOFA