[Hormonal disturbances and the treatment of refractory forms of congestive circulatory insufficiency].
In 109 patients with congestive circulatory insufficiency daily aldosterone excretion was examined by thin-layer chromatography, and in 50 patients aldosteronuria was compared with the excretion of electrolytes and haemodynamic parameters. The daily excretion of aldosterone under the effect of Prednisolone and other saluretics was studied along with the daily excretion of glucocorticoids under the effect of Prednisolone. The efficacy of a combination of drugs (Aldactone, Furosemid, Prednisolone) was studied in patients with refractory forms of circulatory insufficiency. The obtained data revealed an increase of the mineralocorticoid function and a decrease of the glucocorticoid function of the adrenals, a close correlation existing between the level of aldosteronuria, central haemodynamics pattern and electrolytes excretion. Therapy with Prednisolone results in a reduction of aldosteronuria, without causing any inhibition of the glucocorticoid function. The best therapeutic effect was obtained with a combination of Prednisolone, Aldactone, Furosemid, that caused distinct diuresis, natriuresis, increased blood plasma potassium levels, reduction of total dody fluid and body weight.
D000450:Aldosterone / Q000652:urine*; D001834:Body Water / Q000187:drug effects; D002940:Circadian Rhythm; D004231:Diuresis / Q000187:drug effects; D004359:Drug Therapy, Combination; D005665:Furosemide / Q000627:therapeutic use; D005938:Glucocorticoids / Q000652:urine*; D006333:Heart Failure / Q000188:drug therapy / Q000652:urine*; D006801:Humans; D011239:Prednisolone / Q000627:therapeutic use; D013148:Spironolactone / Q000627:therapeutic use; D014882:Water-Electrolyte Balance / Q000187:drug effects
D005938:Glucocorticoids; D013148:Spironolactone; D000450:Aldosterone; D005665:Furosemide; D011239:Prednisolone
Gormonal'nye narusheniia i lechenie bol'nykh s refrakternymi formami zastoĭnoĭ zerdechnoĭ nedostatochnosti