Evaluation of V max TP as an index of myocardial contractility during afterload and preload elevations.
In order to test if the maximal velocity of shortening (V max TP) reflects the level of inotropism and is affected by preload and afterload, the behavior of this index was compared in two groups of anesthetized, atropinized dogs when preload and afterload were raised with an angiotensin II infusion. In seven dogs (group I), the arterial pressure elevation was allowed to inhibit reflectively the sympathetic tone and depress contractility. In eleven dogs (group II), the adrenergic activity was abolished by previous administration of reserpine. In group I, there was a significant decrease in V max TP during the angiotensin infusion. In group II, there was no significant change in the value of this index when the drug was infused. In six animals of this group, a further increase of arterial pressure was induced, but the values of V max TP remained similar to control. These results suggest that this index reflects the inotropic state of the myocardium and does not suffer significantly from the influence of preload and afterload elevations within our experimental limits.
D000804:Angiotensin II / Q000008:administration & dosage / Q000494:pharmacology; D000818:Animals; D001285:Atropine / Q000008:administration & dosage / Q000494:pharmacology; D001794:Blood Pressure / Q000187:drug effects; D004285:Dogs; D005069:Evaluation Studies as Topic; D006334:Heart Function Tests / Q000379:methods*; D006439:Hemodynamics / Q000187:drug effects; D007273:Injections, Intramuscular; D007275:Injections, Intravenous; D008297:Male; D009200:Myocardial Contraction / Q000187:drug effects; D011311:Pressoreceptors / Q000187:drug effects; D011941:Receptors, Adrenergic / Q000187:drug effects; D012110:Reserpine / Q000008:administration & dosage / Q000494:pharmacology; D014439:Tyramine / Q000008:administration & dosage / Q000494:pharmacology
D011941:Receptors, Adrenergic; D000804:Angiotensin II; D001285:Atropine; D012110:Reserpine; D014439:Tyramine