Efferent enhancement of a methylcholanthrene-induced sarcoma transplantable in strain 13 guinea pigs.
The immunobiology of an antigenic methylcholanthrene-induced sarcoma (MC-D) of inbred strain 13 guinea pigs has been investigated. The induction of concomitant immunity by growing MC-D tumors was indicated by the suppression of small tumor inocula in the presence of a large tumor cell dose and by the regression of intradermal tumor nodules. Furthermore, it was demonstrated that this tumor was coated with antibody in vivo. Previous studies showed that MC-D tumors were infiltrated with killer T cells which were capable of complete tumor destruction in vitro, but could never induce spontaneous regression in vivo. On the basis of all these facts, antibody-mediated efferent enhancement is proposed to be the major escape mechanism of this tumor.
D000818:Animals; D000912:Antibodies, Neoplasm; D004306:Dose-Response Relationship, Immunologic; D006168:Guinea Pigs; D007165:Immunosuppression Therapy; D008748:Methylcholanthrene; D009368:Neoplasm Transplantation; D012513:Sarcoma, Experimental / Q000276:immunology*
D000912:Antibodies, Neoplasm; D008748:Methylcholanthrene