[Experimental determination of blood-alcohol metabolism with dogs in haemorrhagic shock (author's transl)].
Ethanol at a dosage of 3 g/kg reduced body weight was injected i.v. into mongrel dogs resulting in a blood alcohol concentration of approximately 2.9 mg/ml. One hour after injection the dogs were anaesthetized with halothane-N20/02 and blood was withdrawn until the blood pressure was reduced to 40 mmHg. This usually required removal of about 30 - 40% of the total blood volume. The resulting haemorrhagic shock was ascertained by monitoring blood pH, pCO2, pO2, lactate, pyruvate and blood electrolytes. A blood specimen for enzymatic alcohol determination (ADH) was obtained every 30 min over a period of 3 hours. Compared with equally dosed controls the dogs in haemorrhagic shock showed a significant (p = 0.005) reduction of the blood alcohol decay rate (beta) which is explained by 1) the diminished blood flow through the liver and 2) the hypoxaemic metabolic situation in shock.
D000818:Animals; D001794:Blood Pressure; D002118:Calcium / Q000097:blood; D004285:Dogs; D000431:Ethanol / Q000097:blood*; D007773:Lactates / Q000097:blood; D008099:Liver / Q000378:metabolism / Q000473:pathology; D011188:Potassium / Q000097:blood; D011773:Pyruvates / Q000097:blood; D012771:Shock, Hemorrhagic / Q000378:metabolism*; D012964:Sodium / Q000097:blood
D007773:Lactates; D011773:Pyruvates; D000431:Ethanol; D012964:Sodium; D011188:Potassium; D002118:Calcium
Tierexperimentelle Untersuchungen über den Blutalkoholabbau im standardisierten hämorrhagischen Schock