Effect of antibiotics on interferon production in mice.
Neomycin, chloramphenicol, gentamycin, rifampicin and oxytetracycline were tested for their influence on virus induced interferon (IF) production in mice. Repeated intraperitoneal (i.p.) injections of antibiotics were given to produce significant serum concentrations during the time of IF production, induced by i.p. injections of Newcastle disease virus (NDV). IF titres in antibiotic-treated mice determined 6 hours after induction were compared to titres in control mice given NDV only. The IF production was not significantly modified in most of the antibiotic treated mice. Only the highest dose of chloramphenicol (2500 mug/mouse) appeared to cause a reduction in IF production (p less than 0.10). Addition of antibiotics in vitro did not alter the antiviral titres of IF.
D000818:Animals; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D002701:Chloramphenicol / Q000494:pharmacology; D003513:Cycloheximide / Q000494:pharmacology; D005839:Gentamicins / Q000494:pharmacology; D007372:Interferons / Q000096:biosynthesis*; D051379:Mice; D009355:Neomycin / Q000494:pharmacology; D009522:Newcastle disease virus; D010118:Oxytetracycline / Q000494:pharmacology; D012293:Rifampin / Q000494:pharmacology
D000900:Anti-Bacterial Agents; D005839:Gentamicins; D002701:Chloramphenicol; D007372:Interferons; D003513:Cycloheximide; D009355:Neomycin; D012293:Rifampin; D010118:Oxytetracycline