The peritoneal reaction to starch and its modification by prednisone.
A saline suspension of 1.5 g of starch powder (Biosorb) inoculated into the peritoneal cavity of rats produced a massive granulomatous reaction which persisted for up to 18 months. From 15 months onwards, starch particles could only be detected with PAS staining. Prednisone at a dosage of approximately 1 mg/kg daily by the oral route produced significant reduction of this phenomenon only when commenced 2 weeks before inoculation. Therapy commenced at the time of starch inoculation had only a minor effect on this response, but if commenced 2 weeks after inoculation failed to ameliorate the granulomatous reaction.
D000818:Animals; D005260:Female; D006099:Granuloma / Q000139:chemically induced* / Q000188:drug therapy / Q000473:pathology; D010503:Periodic Acid-Schiff Reaction; D010537:Peritoneum / Q000187:drug effects*; D010538:Peritonitis / Q000139:chemically induced* / Q000517:prevention & control; D011241:Prednisone / Q000627:therapeutic use*; D051381:Rats; D013213:Starch; D013997:Time Factors
D013213:Starch; D011241:Prednisone