[Effect of ursodesoxycholic acid and cholic acid on intestinal absorption of cholesterol].
A study was carried out to investigate the effect of ursodesoxycholic acid and cholic acid on intestinal absorption of cholesterol-4-14C administered p.o. to lymph-fistula rats. The results indicated that within 24 hours, the labeled cholesterol detected in thoracic duct lymph of the control group was 21.0% of the administered cholesterol-4-14C, whereas the group treated with cholic acid (250 mg/kg p.o.) was found to have an increased value of 30.6% absorbed cholesterol. In comparison, the group treated with the same dose of ursodesoxycholic acid showed a decreased value of 12.1%, indicating an inhibitory effect on cholesterol absorption by the compound. This differential effect of the two compounds was also observed in a time-course study.
D000818:Animals; D002635:Chenodeoxycholic Acid / Q000494:pharmacology*; D002784:Cholesterol / Q000008:administration & dosage / Q000378:metabolism*; D002793:Cholic Acids / Q000494:pharmacology*; D005260:Female; D007408:Intestinal Absorption / Q000187:drug effects*; D007536:Isomerism; D008196:Lymph / Q000032:analysis; D051381:Rats; D013897:Thoracic Duct
D002793:Cholic Acids; D002635:Chenodeoxycholic Acid; D002784:Cholesterol