title: Scleroderma in childhood.
abstract: Scleroderma in childhood is a rare but confusing disorder. Systemic and diffuse disease do occur but are uncommon. Much more common are local lesions of different types which can be multiple; these are often associated with joint symptoms and the development of joint contractures and tendon contractures due to nodule formation. In such circumstances the condition mimics juvenile chronic polyarthritis (Still's disease). A third, rare variant, sclerodermatous fasciitis, has also been described in one young patient.
mesh_terms: D000293:Adolescent; D000367:Age Factors; D001171:Arthritis, Juvenile / Q000175:diagnosis; D001847:Bone Diseases / Q000188:drug therapy; D002648:Child; D002699:Chlorambucil / Q000627:therapeutic use; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D007592:Joint Diseases / Q000188:drug therapy; D008297:Male; D010396:Penicillamine / Q000627:therapeutic use; D011241:Prednisone / Q000627:therapeutic use; D011859:Radiography; D012594:Scleroderma, Localized / Q000473:pathology; D012595:Scleroderma, Systemic / Q000175:diagnosis / Q000188:drug therapy / Q000473:pathology; D012867:Skin / Q000473:pathology; D014457:Ulna / Q000000981:diagnostic imaging
chemical_list: D002699:Chlorambucil; D010396:Penicillamine; D011241:Prednisone