title: Prostaglandins and polyunsaturated fatty acids in heart muscle.
abstract: 1. Dietary lipids modify fatty acid composition of cardiac lipids. Polyunsaturated fatty acids replace less unsaturated fatty acids in phospholipds. 2. Mortality following isoproterenol-stimulation increase with decreasing amount of arachidonic acid in cardiac phospholipds. 3. In normal human heart muscle the ratio of essential, omega-6/nonessential, omega-3 fatty acids diminshes from age 17 to age 50 years. 4. In sudden cardiac death the ratio of prostaglandin substrate, C20:4, to prostaglandin inhibitor, C22:6, is frequently much higher than expected.
mesh_terms: D000367:Age Factors; D000818:Animals; D001344:Autopsy; D003327:Coronary Disease / Q000378:metabolism; D005231:Fatty Acids, Unsaturated / Q000378:metabolism*; D005260:Female; D008297:Male; D009206:Myocardium / Q000378:metabolism*; D009336:Necrosis; D010743:Phospholipids / Q000378:metabolism; D011453:Prostaglandins / Q000378:metabolism*; D051381:Rats; D012737:Sex Factors
chemical_list: D005231:Fatty Acids, Unsaturated; D010743:Phospholipids; D011453:Prostaglandins