Use of cluster analysis in the development of structure-activity relations for antitumor triazenes.
A series of antitumor triazenes in which the members of the series are physicochemically distinct was designed using the cluster analysis approach as proposed by Hansch and his co-workers. The series that resulted was tested against Sarcoma 180 in the mouse and the antitumor activities were analyzed using regression techniques. The structure-activity relations that resulted are discussed in terms of proposed mechanisms of action.
D000818:Animals; D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000627:therapeutic use / Q000633:toxicity; D005163:Factor Analysis, Statistical; D005260:Female; D007928:Lethal Dose 50; D051379:Mice; D008956:Models, Chemical; D012044:Regression Analysis; D012510:Sarcoma 180 / Q000188:drug therapy; D013329:Structure-Activity Relationship; D014226:Triazenes / Q000138:chemical synthesis* / Q000627:therapeutic use / Q000633:toxicity
D000970:Antineoplastic Agents; D014226:Triazenes