[Study of the mechanism of action of fasciolocides using bimolecular phospholipid membranes].
The effects of compounds (see article), where M = -S-, -SO-, -SO2- and of some of their derivatives (18 substances) on electroconductivity of bimolecular lipid membranes (BLM) of different composition in 30 mM tris-HCl (pH 7.5) is studied. The results obtained are compared with literature data concerning fasciolocide and toxic effect of these substances. Certain correlations are found between the action on BLM and biological effects of substances. The analysis of the results allowed a conclusion that the latter are concerned with a discoupling effect of substances on oxidative phosphorylation in mitochondria of helmets and their host. BLM may be applied for evaluating the value of fasciolocide and toxic effects of the substances protonophores.
D000980:Antiplatyhelmintic Agents / Q000494:pharmacology* / Q000633:toxicity; D004353:Drug Evaluation, Preclinical; D005210:Fasciola hepatica / Q000187:drug effects*; D007928:Lethal Dose 50; D008567:Membranes, Artificial; D010743:Phospholipids; D013440:Sulfides / Q000494:pharmacology* / Q000633:toxicity; D013450:Sulfones / Q000494:pharmacology* / Q000633:toxicity; D013454:Sulfoxides / Q000494:pharmacology* / Q000633:toxicity
D000980:Antiplatyhelmintic Agents; D008567:Membranes, Artificial; D010743:Phospholipids; D013440:Sulfides; D013450:Sulfones; D013454:Sulfoxides
Issledovanie mekhanizma deĭstviia fastsiolotsidov s pomoshch'ie bimolekuliarnykh fosfolipidnykh membran