title: Tolciclate against dermatophytes.
abstract: 0-(1,2,3,4-Tetrahydro-1,4-methanonaphthalen-6-yl)-m-N-dimethylthiocarbanilate (toliciclate; KC 9147) is a new topical antimycotic having an in vitro activity on dermatophytes between 0.1 and 0.01 mug/ml. It is fungicidal after some day's contact. It has the advantage over dyes used in the past for topical treatment of dermatomycoses in that it is colourless and is soluble in well tolerated excipients. It is more liposoluble than tolnaftate. In the guineapig skin infections with Trichophyton asteroides and Microsporum canis, it is usually 3 times more active than tolnaftate and, in some tests, up to 10 times.
mesh_terms: D000818:Animals; D003883:Arthrodermataceae / Q000187:drug effects*; D001234:Aspergillus niger / Q000187:drug effects; D003881:Dermatomycoses / Q000188:drug therapy; D004285:Dogs; D005260:Female; D006168:Guinea Pigs; D007928:Lethal Dose 50; D008297:Male; D051379:Mice; D008826:Microbial Sensitivity Tests; D008864:Microsporum / Q000187:drug effects; D011247:Pregnancy; D011817:Rabbits; D051381:Rats; D012869:Skin Absorption; D012995:Solubility; D013859:Thiocarbamates / Q000494:pharmacology* / Q000627:therapeutic use / Q000633:toxicity; D014047:Tolnaftate / Q000627:therapeutic use; D014249:Trichophyton / Q000187:drug effects
chemical_list: D013859:Thiocarbamates; D014047:Tolnaftate