Repair synthesis of DNA after irradiation and its modification due to radioprotection in vivo.
Repair DNA synthesis was examined in bone marrow cells exposed to LD 50/30 in vivo. Intensive repair synthesis took place during the irradiation, and the increase in 3HTdR uptake prevailed over the inhibitory effect of radiation and AET upon DNA synthesis. After LD 50/30, the intensity of DNA repair was reduced. Application of AET resulted in an increase in repair DNA synthesis after irradiation, indicated by a significantly higher incorporation of 3HTdR.
D000818:Animals; D001853:Bone Marrow / Q000528:radiation effects; D001854:Bone Marrow Cells; D006224:Cricetinae; D004260:DNA Repair / Q000187:drug effects / Q000528:radiation effects; D004261:DNA Replication; D000338:beta-Aminoethyl Isothiourea / Q000494:pharmacology*
D000338:beta-Aminoethyl Isothiourea