Quantitative and thermodynamic studies of erythrocytic ABO antigens.
This paper presents recent data from quantitative and thermodynamic investigations on A and B erythrocyte antigens. In regard to weak A phenotypes on the basis of quantitative data, practically no gap is observed from the weakest Aend to the strongest A3. Weak B phenotypes give a similar distribution. However, a more precise structural analysis including kinetics and thermodynamic measurements provides convincing evidence for the heterogeneity of each type of weak B reactive structures. Weak B antigens appear to be different from one to another, but similar inside one family. However, thermodynamics failed to demonstrate a qualitative difference between the weak B antigen in BX groups and the enhanced B antigen in ABX heterozygote, phenomenon that occurs in some very rare families. The same data were obtained from kinetic and thermodynamic analysis of B reactivity in cis AB samples; it can be assumed that such mutants are all different.
D000017:ABO Blood-Group System; D006386:Hemagglutination Tests; D006801:Humans; D007106:Immune Sera / Q000494:pharmacology; D007519:Isoantigens / Q000032:analysis; D007700:Kinetics; D010375:Pedigree; D010641:Phenotype; D014176:Protein Biosynthesis; D013816:Thermodynamics
D000017:ABO Blood-Group System; D007106:Immune Sera; D007519:Isoantigens