[Effect of strophanthin on the metabolism, electrolyte content, myocardial ultrastructure and contractile function of the heart in the peri-infarction zones in experimental infarct].
The results of a complex study are presented dealing with the effect of Strophantin on metabolism, electrolytes content, myocardial ultrastructure and contractile function of various portions of the heart in dogs with experimentally induced infarction. Under the effect of Strophantin the destructive alterations of the myocardial ultrastructure, the electrolytes shifts and disorders in the contractile function of the myocardium in the zone of impaired circulation (25 min.) were less severe than in non-treated dogs. A more distinct beneficial effect of Strophantin upon the structural-functional state of the myocardium was revealed in the parainfarction zones after 2 days and 2 weeks following the ligation of the coronary artery. A reduction of potassium and sodium content in the paranecrotic zone of the myocardium in early postinfarction periods in treated animals must be largely due to the more active ion diffusion in this zone of the infarction caused by improved microcirculation.
D000818:Animals; D004285:Dogs; D004562:Electrocardiography; D004573:Electrolytes / Q000378:metabolism*; D005260:Female; D006321:Heart / Q000187:drug effects*; D008297:Male; D009200:Myocardial Contraction / Q000187:drug effects*; D009203:Myocardial Infarction / Q000188:drug therapy* / Q000503:physiopathology; D009206:Myocardium / Q000378:metabolism* / Q000648:ultrastructure; D011188:Potassium / Q000378:metabolism; D012964:Sodium / Q000378:metabolism; D013328:Strophanthins / Q000494:pharmacology*; D013997:Time Factors
D004573:Electrolytes; D013328:Strophanthins; D012964:Sodium; D011188:Potassium
Vliianie strofantina na metabolizm, soderzhanie élektrolitov, ul'trastrukturu miokarda i sokratitel'nuiu funktsiiu serdtsa v okoloinfarktnykh zonakh pri éksperimental'nom infarkte