title: Further evidence of permanent behavioural changes in rats treated neonatally with neurodrugs.
abstract: Pargyline or reserpine treatment of male rats during the first two weeks of life resulted in significantly increased exploratory activity (sniffing) associated with a significantly decreased emotional reactivity (defecation rate) in adult life. These findings suggest that nonphysiological concentrations and/or turnover rates of neurotransmitters during brain differentiation apparently produced by neurodrugs can lead to permanent behavioural changes.
mesh_terms: D000818:Animals; D000831:Animals, Newborn / Q000254:growth & development*; D001522:Behavior, Animal / Q000187:drug effects*; D001921:Brain / Q000254:growth & development; D004609:Eliminative Behavior, Animal / Q000187:drug effects; D004644:Emotions / Q000187:drug effects; D005106:Exploratory Behavior / Q000187:drug effects; D008297:Male; D010293:Pargyline / Q000494:pharmacology*; D051381:Rats; D012110:Reserpine / Q000494:pharmacology*
chemical_list: D012110:Reserpine; D010293:Pargyline