Iatrogenic factors in femoral neck fractures.
A study of 200 femoral neck fractures in ambulant patients showed that 62 per cent of subcapital and 58 per cent of trochanteric fractures occurred without a significant history of injury. It was also observed that almost 70 per cent of patients in this group were on long-term medication which could affect bone density. In the remaining patients with a definite history of injury, only 20 per cent and 21 per cent respectively were on long-term therapy, figures which corresponded to the 18 per cent of patients on prolonged medication attending with minor injuries (age- and sex-matched). The action of corticosteroids, thyroxine, phenobarbitone, phenytoin, frusemide and bendrofluazide on bone density and their responsibility for femoral neck fractures are discussed.
D000305:Adrenal Cortex Hormones / Q000009:adverse effects; D000368:Aged; D000927:Anticonvulsants / Q000009:adverse effects; D004232:Diuretics / Q000009:adverse effects; D064420:Drug-Related Side Effects and Adverse Reactions; D005260:Female; D005265:Femoral Neck Fractures / Q000209:etiology*; D006801:Humans; D007049:Iatrogenic Disease; D008297:Male; D013974:Thyroxine / Q000009:adverse effects
D000305:Adrenal Cortex Hormones; D000927:Anticonvulsants; D004232:Diuretics; D013974:Thyroxine