title: Ibuprofen (motrin) hypersensitivity in intrinsic and extrinsic allergic patients.
abstract: The introduction of new anti-inflammatory chemicals derived from propionic acid raised the possibility that they would not cross-react with the aspirin-salicylate type of anti-inflammatory drugs (and this group's cross-reactant chemicals). Thic allergic patients who have low tolerance for aspirin or BHA-BHT if concomitant low tolerance for iodides is also present. Likewise, ibuprofen is poorly tolerated by iodide intolerant patients. However, ASA or BHA-BHT intolerant patients who are tolerant of iodides tolerate a single 400 mgm motrin challenge; chronic motrin usage awaits further study. This study indicates that motrin is tolerated in patients tolerant of iodides but who suffer with extrinsic, atopic, allergic diseases and also in normals.
mesh_terms: D001241:Aspirin / Q000009:adverse effects; D001780:Blood Coagulation Tests; D002083:Butylated Hydroxyanisole / Q000009:adverse effects; D002084:Butylated Hydroxytoluene / Q000009:adverse effects; D004342:Drug Hypersensitivity / Q000209:etiology*; D004361:Drug Tolerance; D006801:Humans; D006967:Hypersensitivity / Q000188:drug therapy*; D006969:Hypersensitivity, Immediate / Q000188:drug therapy; D007052:Ibuprofen / Q000009:adverse effects* / Q000627:therapeutic use; D010666:Phenylpropionates / Q000009:adverse effects*
chemical_list: D010666:Phenylpropionates; D002084:Butylated Hydroxytoluene; D002083:Butylated Hydroxyanisole; D001241:Aspirin; D007052:Ibuprofen