title: Tyrosine hydroxylation in the rat striatum after fentanyl and droperidol in vivo.
abstract: The effects of fentanyl, droperidol, and morphine on tyrosine hydroxylation in the rat striatum was measured after inhibition of aromatic amino acid decarboxylase with R04-4602. Any direct change in the product of hydroxylation (i.e.dopa) was supposed to reflect a change in enzyme activity. Fentanyl (0.1 mg/kg intraperitoneally) first (10 min) appears to slightly depress, and later (30 min) significantly activate tyrosine hydroxylation. Morphine (10 mg/kg i.p.) activates tyrosine hydroxylation to a much lesser degree than fentanyl. Droperidol (3 mg/kg i.p.) only slightly activates the in vivo activity of the enzyme.
mesh_terms: D000818:Animals; D001545:Benserazide / Q000494:pharmacology; D003342:Corpus Striatum / Q000187:drug effects*; D004295:Dihydroxyphenylalanine / Q000096:biosynthesis; D004329:Droperidol / Q000494:pharmacology*; D005283:Fentanyl / Q000494:pharmacology*; D006900:Hydroxylation; D008297:Male; D009020:Morphine / Q000494:pharmacology; D051381:Rats; D014443:Tyrosine / Q000378:metabolism*
chemical_list: D014443:Tyrosine; D004295:Dihydroxyphenylalanine; D001545:Benserazide; D009020:Morphine; D004329:Droperidol; D005283:Fentanyl