The effect of 2-bromo-alpha-ergocryptine (CB154) administration of the hormone levels, organ weights, prostatic morphology and zinc concentrations in the male rat.
2-Bromo-alpha-ergocryptine (CB154) administration to male rats produced a significant decrease in plasma prolactin levels without changing the LH and testosterone concentrations. The weights of the accessory sex tissues, testes, adrenals and kidney were unaltered by the treatment. Zinc concentration and distribution in the cell organelles of the prostatic tissue was markedly changed by CB154 treatment. No changes in the uptake of testosterone in vivo occurred in the treated animals. Prolactin did not consistently influence the prostatic adenyl cyclase activity in vitro and only at high concentrations was the testosterone uptake in vitro with cultures of prostatic tissue increased.
D000262:Adenylyl Cyclases / Q000378:metabolism; D000311:Adrenal Glands / Q000033:anatomy & histology; D000818:Animals; D001971:Bromocriptine / Q000494:pharmacology*; D046508:Culture Techniques; D004873:Ergolines / Q000494:pharmacology*; D005260:Female; D007986:Luteinizing Hormone / Q000097:blood / Q000378:metabolism*; D008297:Male; D009929:Organ Size / Q000187:drug effects; D011388:Prolactin / Q000097:blood / Q000378:metabolism* / Q000494:pharmacology; D011467:Prostate / Q000187:drug effects* / Q000378:metabolism / Q000648:ultrastructure; D051381:Rats; D013737:Testis / Q000033:anatomy & histology; D013739:Testosterone / Q000097:blood / Q000378:metabolism*; D015032:Zinc / Q000378:metabolism*
D004873:Ergolines; D001971:Bromocriptine; D013739:Testosterone; D011388:Prolactin; D007986:Luteinizing Hormone; D000262:Adenylyl Cyclases; D015032:Zinc