The influence of acute diazepam pretreatment on the action and disposition of [14C]pentobarbital in rats.
Diazepam (DZP) pretreatment (100mg/kg, ip) of rats 6 h before pentobarbital administration (45 mg/kg, ip) prolonged the barbiturate-induced narcosis. The concentrations of [14C]pentobarbital and total pentobarbital derivatives in blood or brain showed no differences between control and DZP-pretreated animals. The brain and blood concentrations of pentobarbital, when measured at a time corresponding to the respective arousal times from pentobarbital narcosis, were lower in the DZP-pretreated group. These results indicate that acute DZP pretreatment increases the sensitivity of the rat brain to pentobarbital rather than inducing changes in the disposition of the barbiturate.
D000818:Animals; D001798:Blood Proteins / Q000378:metabolism; D003975:Diazepam / Q000494:pharmacology*; D008297:Male; D010424:Pentobarbital / Q000378:metabolism / Q000494:pharmacology*; D011485:Protein Binding; D051381:Rats; D012890:Sleep / Q000187:drug effects; D013997:Time Factors
D001798:Blood Proteins; D010424:Pentobarbital; D003975:Diazepam