[The effect of 2,4-dinitrophenol, monoiodine acetate, sodium fluoride and hypoxia on the formation of plasma polyps in the placenta of guinea pigs (author's transl)].
Plasma polyps can be found at the end of a normal pregnancy. Following NaF and MJA-intoxication, there is an extreme increase of plasma polyps. This accelerated formation can be prevented by the injection of Na-pyruvate and often the number of polyps can be reduced below the norm. 2,4-Dinitrophenol intoxication and breathing of hypoxic gas mixture (2,5% O2, 5% CO2, 92,5% N2) do not lead to increased plasma polyp formation. This proves, that it is not hypoxia, not an energy deficit secondary to separation of oxydative phosphorylation and not cardiac insufficiency leading to secondary ischemia which are responsible for the extreme increase in the number of plasma polyps following the injection of MJA and NaF.
D000085:Acetates / Q000494:pharmacology*; D000818:Animals; D004140:Dinitrophenols / Q000494:pharmacology*; D005260:Female; D005459:Fluorides / Q000494:pharmacology*; D006168:Guinea Pigs; D000860:Hypoxia / Q000473:pathology*; D010920:Placenta / Q000187:drug effects*; D010922:Placenta Diseases / Q000139:chemically induced; D011127:Polyps / Q000209:etiology; D011247:Pregnancy; D011773:Pyruvates / Q000494:pharmacology
D000085:Acetates; D004140:Dinitrophenols; D011773:Pyruvates; D005459:Fluorides
Einfluss von 2,4-Dinitrophenol, Monojodacetat, Natriumfluorid und Hypoxie auf Plasmapolypenbildung in der Placenta von Meerschweinchen