Inhibition of transmembrane K transfer in ureter-ligated dogs infused with KCl.
In anuric dogs loaded with K by infusion with 2 meq KCl/kg per h until prelethal hyperkalemic cardiotoxicity appears, the extent of transmembrane K transfer depends on the origin of the anuria. Animals with bilateral ureter ligation transfer a mean of 1.2 meq/kg to intracellular fluid, while those with bilateral nephrectomy transfer more than 2.5 times as much (3.1 meq/kg). Further, if dogs with functioning kidneys are ureter ligated or nephrectomized after approximately 45 min of K loading, K transfer ultimately falls as infusion continues. The fall is precipitate and over 90% in ligated animals; but it is gradual, and only 10% in those that are nephrectomized. Finally, K transfer, because of the absence of insulin, is negligible in K-loaded pancreatectomized dogs with bilateral ureter ligation, but fairly substantial in pancreatectomized animals with bilateral nephrectomy. The data suggest that ureter ligation and hyperkalemia activate a renal mechanism that interferes with the transfer of infused K to intracellular fluid. The mechanism may involve the renin-angiotensin II-aldosterone system to a limited degree.
D000818:Animals; D001692:Biological Transport; D004285:Dogs; D004912:Erythrocytes / Q000378:metabolism; D005110:Extracellular Space / Q000378:metabolism; D005260:Female; D007668:Kidney / Q000502:physiology; D008026:Ligation; D008297:Male; D009392:Nephrectomy; D010179:Pancreas / Q000502:physiology; D010180:Pancreatectomy; D011188:Potassium / Q000097:blood / Q000378:metabolism*; D014513:Ureter / Q000502:physiology*
D011188:Potassium