title: Hypoxanthine-guanine phosphoribosyltransferase mutant glioma cells: diminished monamine oxidase activity.
abstract: A defective capability of cultured rat glioma cells to reutilize purine bases (hypoxanthine-guanine phosphoribosyltransferase deficiency) was associated with a reduced capacity to oxidatively deaminate serotonin and tryptamine. The mutant glioma cells were also more sensitive to the cytotoxic effects of serotonin than were normal cells
mesh_terms: D002460:Cell Line; D002470:Cell Survival / Q000187:drug effects; D005910:Glioma; D007041:Hypoxanthine Phosphoribosyltransferase / Q000172:deficiency*; D008995:Monoamine Oxidase / Q000172:deficiency*; D009457:Neuroglia / Q000201:enzymology*; D012701:Serotonin / Q000378:metabolism / Q000633:toxicity*; D014363:Tryptamines / Q000378:metabolism
chemical_list: D014363:Tryptamines; D012701:Serotonin; D008995:Monoamine Oxidase; D007041:Hypoxanthine Phosphoribosyltransferase