Ultrastructure of the haemophilic synovial membrane and electron-probe X-ray analysis of haemosiderin.
An ultrastructural study of the haemophilic synovial membrane revealed the presence of solitary siderosomes, compound siderosomes and a peppering of the cell cytoplasm with electron-dense particles. These changes were found in synovial intimal cells, subsynovial macrophages and fibroblasts. Electron-probe X-ray analysis of siderosomes revealed the presence of iron and traces of phosphorus. On the basis of previous and present studies it is postulated that haemosiderin is essentially a condensate of hydrated ferric oxide and that a variable amount of phospholipid material lies in company with it in the siderosome.
D000328:Adult; D004577:Electron Probe Microanalysis; D005290:Ferric Compounds / Q000032:analysis; D006395:Hemarthrosis / Q000473:pathology*; D006467:Hemophilia A / Q000150:complications; D006485:Hemosiderin / Q000032:analysis*; D006801:Humans; D008297:Male; D008854:Microscopy, Electron; D013583:Synovial Membrane / Q000032:analysis / Q000648:ultrastructure*
D005290:Ferric Compounds; D006485:Hemosiderin