Anticonvulsant-induced dyskinesias: a comparison with dyskinesias induced by neuroleptics.
Anticonvulsants cause dyskinesias more commonly than has been appreciated. Diphenylhydantoin (DPH), carbamazepine, primidone, and phenobarbitone may cause asterixis. DPH, but not other anticonvulsants, may cause orofacial dyskinesias, limb chorea, and dystonia in intoxicated patients. These dyskinesias are similar to those caused by neuroleptic drugs and may be related to dopamine antagonistic properties possessed by DPH.
D000293:Adolescent; D000328:Adult; D000368:Aged; D000927:Anticonvulsants / Q000009:adverse effects* / Q000097:blood / Q000506:poisoning; D002220:Carbamazepine / Q000009:adverse effects; D002526:Cerebellar Diseases / Q000139:chemically induced; D002819:Chorea / Q000139:chemically induced; D004409:Dyskinesia, Drug-Induced; D005121:Extremities; D005152:Facial Muscles; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009759:Nystagmus, Pathologic / Q000139:chemically induced; D010634:Phenobarbital / Q000009:adverse effects; D010672:Phenytoin / Q000009:adverse effects; D011324:Primidone / Q000009:adverse effects; D013577:Syndrome; D014149:Tranquilizing Agents / Q000009:adverse effects*; D014202:Tremor / Q000139:chemically induced
D000927:Anticonvulsants; D014149:Tranquilizing Agents; D011324:Primidone; D002220:Carbamazepine; D010672:Phenytoin; D010634:Phenobarbital