A computer simulation of the effect of injected anti-progesterone on progesterone levels of pregnant rats.
Antibodies to progesterone injected into pregnant rats, provoke abortion if the concentration of the biologically active progesterone is reduced to a critical level. By stimulating the biological experiments in the computer we describe the time dependent changes of this progesterone fraction, as a function of the initial concentration of progesterone and of the anti-progesterone injected. Results obtained can be used to aid interpreting the findings of the biological studies and to calculate the concentration of anti-progesterone required to provoke abortion.
D000028:Abortion, Induced; D000818:Animals; D000937:Antigen-Antibody Reactions; D003201:Computers; D005260:Female; D007106:Immune Sera; D007700:Kinetics; D008433:Mathematics; D008954:Models, Biological; D011247:Pregnancy; D011374:Progesterone / Q000097:blood* / Q000276:immunology; D051381:Rats
D007106:Immune Sera; D011374:Progesterone