Characteristics of natural anti-NP antibodies in different strains of mice.
Characteristics (titre and fine-specificity) of natural anti-NP antibodies were determined in eighteen inbred strains of mice. We found systematic titre and fine-specificity differences between different strains. At least five types of strains could be easily detected but the data indicate that the actual number is greater. Strains sharing an Ig allotype tended to have less different anti-NP antibodies than those not sharing the allotype. Fine-specificity of natural anti-NP antibodies resembled fine-specificity characteristics in immune anti-NP antibodies of the same strains. Both are probably controlled by V genes. The data indicate that fine-specificity of antibodies has a great resolving power in the study of Mendelian V genes.
D000818:Animals; D000918:Antibody Specificity; D005260:Female; D005796:Genes; D008040:Genetic Linkage; D007126:Immunoglobulin Allotypes / Q000145:classification*; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D009596:Nitrophenols / Q000276:immunology*; D013045:Species Specificity
D007126:Immunoglobulin Allotypes; D009596:Nitrophenols