[Rate of tetracycline dissolution from tablets and capsules and the biological availability of the antibiotic].
Relation between the rate of tetracycline dissolution from tablets and capsules and the biological acceptibility of the antibiotic in the host was studied. The antibiotic dissolution rate from the pharmaceutical forms was determined in a modernized apparatus "Rotary basket" in water, the speed of the basket rotation was 200 r.p.m. In addition the tetracycline blood levels in patients treated with the drug in the above pharmaceutical forms were estimated. It was found that the rate of the antibiotic dissolution characterized the antibiotic biological acceptibility. A test for the dissolution rate was developed. It may be used for estimation of production batches of tetracycline tablets.
D000284:Administration, Oral; D001682:Biological Availability; D002214:Capsules; D004305:Dose-Response Relationship, Drug; D006801:Humans; D007700:Kinetics; D012995:Solubility; D013607:Tablets; D013752:Tetracycline / Q000097:blood / Q000494:pharmacology*; D013997:Time Factors
D002214:Capsules; D013607:Tablets; D013752:Tetracycline
Skorost' rastvorennia tetratsiklina iz tabletok i kapsul i biologicheskaia dostupnost; antibiotika