Effects of d-propranolol and estradiol on the cervicovaginal epithelium.
The cervicovaginal epithelium of neonatal mice produces a material with specific antigenic properties (CVA) and this material is produced in increased amounts after estradiol treatment. Using a cytochemical method, estradiol treatment was shown to result in an increase of adenylate cyclase activity in the same epithelium. When d-propranolol is injected together with estradiol, the increase in CVA is inhibited, while the hormone-induced proliferation of epithelial cells is not influenced. When adenylate cyclase activity is studied under identical conditions, the estradiol-promoted increase in enzyme activity is largely counteracted by d-propranolol. These findings would suggest that Adenosine 3"5"-cyclic monophosphate (cAMP) has a role in some, but not all, estradiol-mediated effects in the neonatal cervicovaginal epithelium.
D000262:Adenylyl Cyclases / Q000378:metabolism*; D000818:Animals; D000831:Animals, Newborn; D000941:Antigens / Q000032:analysis; D002584:Cervix Uteri / Q000201:enzymology* / Q000276:immunology / Q000648:ultrastructure; D004847:Epithelial Cells; D004958:Estradiol / Q000494:pharmacology*; D004965:Estrogen Antagonists; D005260:Female; D006651:Histocytochemistry; D051379:Mice; D011433:Propranolol / Q000494:pharmacology*; D014621:Vagina / Q000201:enzymology* / Q000276:immunology / Q000648:ultrastructure
D000941:Antigens; D004965:Estrogen Antagonists; D004958:Estradiol; D011433:Propranolol; D000262:Adenylyl Cyclases