Enhancement of morphine-withdrawal and apomorphine-induced aggression by clonidine.
Clonidine, a proposed alpha-noradrenergic receptor stimulant, intensifies the aggression occuring during morphine-withdrawal or following the administration of apomorphine. The possibility of a noradrenergic/dopaminergic interaction in drug-induced aggression is discussed.
D000374:Aggression / Q000187:drug effects*; D000818:Animals; D001058:Apomorphine / Q000494:pharmacology*; D003000:Clonidine / Q000494:pharmacology*; D006801:Humans; D008297:Male; D009020:Morphine / Q000494:pharmacology*; D051381:Rats; D013268:Stimulation, Chemical; D013375:Substance Withdrawal Syndrome / Q000139:chemically induced*; D014828:Vocalization, Animal / Q000187:drug effects
D009020:Morphine; D003000:Clonidine; D001058:Apomorphine