title: [Investigations concerning serum concentration and temperature following oral application of a new paracetamol preparation (author's transl)].
abstract: A new, highly concentrated, fluid paracetamol preparation (paracetamol fluid) was tested on 26 small children and school children. The children were divided into 3 groups on the basis of dosage (5, 10 and 20 mg/kg body weight). The paracetamol serum concentration was determined and the temperature reactions noted. The resorption was rapid; maximum serum level was usually reached after 30 minutes. In most cases, maximum drop in temperature, however, occurred in 3-4 hours. The most obvious and longest lasting drop in temperature was achieved fol following 20 mg/kg body weight dose of the paracetamol preparation. Doses of 5 mg/kg body weight had no significant affect on elevated body temperatures. The most favorable dosage then is between 10-20 mg/kg body weight. The paracetamol concentration in the children under study never exceeded that of 20 mug/ml, even with the higher doses (20 mg/kg). This is far below the toxic threshold of 120 mug/ml. Even higher paracetamol doses of 40 mg/kg body weight, such as may be acciddentally administered, only resulted in a maximum serum level of 50 mug/ml and, therefore, were far below the toxic threshold.
mesh_terms: D000082:Acetaminophen / Q000008:administration & dosage / Q000097:blood* / Q000627:therapeutic use; D001831:Body Temperature; D002648:Child; D002675:Child, Preschool; D005334:Fever / Q000097:blood / Q000188:drug therapy*; D006801:Humans; D007223:Infant
chemical_list: D000082:Acetaminophen
vernacular_title: Untersuchungen über Serumkonzentrationen und Temperaturverlauf nach einer neuen oral applizierbaren flüssigen Paracetamolzubereitung