A study of mortality and urinary excretion of oxalate in male rats following acute experimental intoxication with diethylene-glycol. Preliminary report.
Acute intoxication by diethylene glycol (LD 50) in male rats is associated with a considerable urinary excretion of oxalate, which is significantly decreased by alkalinisatin and/or intraperitoneal injection of ethanol with hydration. Mortality during the five days following intoxication is significantly decreased by major hydration only or together with pyridoxine administration, but is cancelled by major hydration together with alkalinisation or intraperitoneal administration of ethanol, plus hydration, with or without alkalinisation. -- It might be inferred that diethylene glycol has the same metabolic pathway as ethylene glycol and treatment of acute intoxication by diethylene-glycol should be the same as that of acute poisoning with ethylene glycol.
D000818:Animals; D000431:Ethanol / Q000494:pharmacology; D005026:Ethylene Glycols / Q000506:poisoning*; D007928:Lethal Dose 50; D008297:Male; D009026:Mortality; D010070:Oxalates / Q000652:urine*; D051381:Rats
D005026:Ethylene Glycols; D010070:Oxalates; D000431:Ethanol