Mechanism of action of acetyl kidamycin. II. Inhibition of RNA synthesis in HeLa cells.
The effects of acetyl kidamycin on RNA synthesis in HeLa cells were investigated. Acetyl kidamycin inhibited the synthesis of 45S pre-rRNA, heterogeneous nuclear RNA (HnRNA) and small molecular weight RNAs, though not to the same degree. The processing of 45S pre-rRNA into 18S and 28S rRNA and that of HnRNA into mRNA were not affected.
D000903:Antibiotics, Antineoplastic / Q000031:analogs & derivatives / Q000494:pharmacology*; D002467:Cell Nucleus / Q000378:metabolism; D003593:Cytoplasm / Q000378:metabolism; D003864:Depression, Chemical; D006367:HeLa Cells / Q000378:metabolism / Q000648:ultrastructure; D006801:Humans; D011061:Poly A / Q000378:metabolism; D012313:RNA / Q000096:biosynthesis*; D012333:RNA, Messenger / Q000378:metabolism
D000903:Antibiotics, Antineoplastic; D012333:RNA, Messenger; D011061:Poly A; D012313:RNA