title: Severe atypical endometrial changes and sequential contraceptive use.
abstract: Of eight young women, seven had a diagnosis of well-differentiated endometrial adenocarcinoma and one had atypical endometrial hyperplasia. The average age was 40.1 years, with 6.04 years of dimethisterone-ethinyl estradiol (Oracon) sequential contraceptive use. The patients were not typical of those in whom endometrial carcinoma develops. Although these cases do not prove that long-term administration of dimethisterone-ethinyl estradiol causes endometrial adenocarcinoma or atypia, they indicate that it may do so.
mesh_terms: D000230:Adenocarcinoma / Q000139:chemically induced* / Q000473:pathology; D000328:Adult; D000367:Age Factors; D004116:Dimethisterone / Q000009:adverse effects*; D004714:Endometrial Hyperplasia / Q000139:chemically induced* / Q000473:pathology; D004997:Ethinyl Estradiol / Q000009:adverse effects*; D005260:Female; D006801:Humans; D007044:Hysterectomy; D008875:Middle Aged; D010298:Parity; D013997:Time Factors; D014594:Uterine Neoplasms / Q000139:chemically induced* / Q000473:pathology
chemical_list: D004997:Ethinyl Estradiol; D004116:Dimethisterone