Concentration of cefamandole in serum interstitial fluid, bile, and urine.
Cefamandole readily diffuses from the serum into soft tissue interstitial fluid. The rate of diffusion differs little from that of cephalothin. The concentrations of antibiotic were greater in bile and urine during the entire period of study than is necessary to kill susceptible pathogenic bacteria present in these fluids.
D000818:Animals; D001646:Bile / Q000378:metabolism*; D001826:Body Fluids / Q000378:metabolism*; D002511:Cephalosporins / Q000378:metabolism* / Q000652:urine; D004285:Dogs; D008333:Mandelic Acids / Q000378:metabolism / Q000652:urine; D013997:Time Factors
D002511:Cephalosporins; D008333:Mandelic Acids