Transplacental induction of lymphomas in Swiss mice by carbendazim and sodium nitrite.
Swiss mice at different stages of pregnancy were treated intragastrically with the pesticide Carbendazim (MBC, BCM, methyl-2-benzimidazole carbamate) together with sodium nitrite. Lymphomas developed in 33.3% of young mice whose mothers were treated in the first week of pregnancy, in 53.3% of whose mothers were treated during the second week, and in 38.8% of those born of mothers treated during the third week. Treatment during the whole period of pregnancy yielded on an average 70.0% malignancy in offspring. However, administration of Carbendazim by itself did not produce lymphomas in the first generation. In lymphomas induced by in vivo-formed n-nitroso compounds, A- and C-type oncornavirus particles were observed with the electron microscope.
D000818:Animals; D001562:Benzimidazoles / Q000008:administration & dosage; D002219:Carbamates / Q000008:administration & dosage; D002273:Carcinogens; D003593:Cytoplasm / Q000648:ultrastructure; D004305:Dose-Response Relationship, Drug; D005260:Female; D005659:Fungicides, Industrial / Q000008:administration & dosage; D005865:Gestational Age; D008214:Lymphocytes / Q000648:ultrastructure; D008228:Lymphoma, Non-Hodgkin / Q000139:chemically induced* / Q000473:pathology; D008431:Maternal-Fetal Exchange; D051379:Mice; D009374:Neoplasms, Experimental / Q000139:chemically induced; D009573:Nitrites / Q000008:administration & dosage; D011247:Pregnancy
D001562:Benzimidazoles; D002219:Carbamates; D002273:Carcinogens; D005659:Fungicides, Industrial; D009573:Nitrites; C006698:carbendazim