The influence of kinins on the action of circulatory drugs. II. The influence of bradylinin on the action of selected drugs on the isolated rat heart.
The influence of bradykinin and bradykinin in conjunction with norepinephrine, epinephrine, isoprenaline, phentolamine and propranolol on the work of the isolated rat heart was studied. Amplitude of cardiac contractions, their frequency, and coronary flow were recorded. The kinin had no influence on the work of the isolated rat heart, inhibited the stimulating action of norepinephrine, epinephrine and isoprenaline on the heart muscle, and had no effect on the action of phentolamine and propranolol.
D000818:Animals; D001920:Bradykinin / Q000494:pharmacology*; D003326:Coronary Circulation / Q000187:drug effects; D004837:Epinephrine / Q000494:pharmacology; D006321:Heart / Q000187:drug effects*; D007545:Isoproterenol / Q000494:pharmacology; D008297:Male; D009200:Myocardial Contraction / Q000187:drug effects; D009638:Norepinephrine / Q000494:pharmacology; D010646:Phentolamine / Q000494:pharmacology; D011433:Propranolol / Q000494:pharmacology; D051381:Rats
D011433:Propranolol; D007545:Isoproterenol; D001920:Bradykinin; D009638:Norepinephrine; D004837:Epinephrine; D010646:Phentolamine