A single-blind comparative study of once daily dothiepin ("Prothiaden") and divided daily doses of amitriptyline.
Forty-eight patients took part in a single-blind clinical trial comparing a once daily dose of dothiepin (75 mg) and 25 mg 3-times a day  of amitriptyline. The results showed that dothiepin caused a greater improvement than amitriptyline after 4 weeks of treatment as judged by depression scores, total scores and global assessments. The  incidence of side-effects was less with dothiepin and in those patients who actually reported side-effects the severity was much less with dothiepin than with amitriptyline.
D000328:Adult; D000639:Amitriptyline / Q000008:administration & dosage* / Q000009:adverse effects / Q000627:therapeutic use; D003863:Depression / Q000188:drug therapy; D003988:Dibenzothiepins / Q000008:administration & dosage*; D004308:Dothiepin / Q000008:administration & dosage* / Q000009:adverse effects / Q000627:therapeutic use; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged
D003988:Dibenzothiepins; D000639:Amitriptyline; D004308:Dothiepin