[Immunostimulating action of thiamine when using purine base analogs].
Experiments were conducted on albino rats; a study was made of the effect of the antigenic stimulation and of the purine base analogues (6-mercaptopurine and azathioprine) on the thiamine content in the spleen, and also of the influence of thiamine load on the antibody biosynthesis induced with the antigen under normal conditions and in administration of immunodepressors. Immunization and administration of the analogues of purine bases caused a reduction of thiamine content in the spleen. An excessive vitamin load compensated this deficiency. Thiamine load stimulated the formation of antibodies and weakened the immunodepressor effect of the purine base analogues significantly.
D000818:Animals; D000917:Antibody Formation / Q000187:drug effects*; D001379:Azathioprine / Q000494:pharmacology*; D007114:Immunization; D007165:Immunosuppression Therapy; D015122:Mercaptopurine / Q000494:pharmacology*; D051381:Rats; D013154:Spleen / Q000032:analysis; D013831:Thiamine / Q000032:analysis / Q000494:pharmacology*
D015122:Mercaptopurine; D001379:Azathioprine; D013831:Thiamine
Immunostimuliruiushchee deĭstvie tiamina v usloviiakh primeneniia analogov purinovykh osnovaniĭ