[Animal experimental study on spasmolytic and analgesic activities of pramiverine, metamizole and their combination (author's transl)].
In two pharmacological in vivo tests a comparative study was performed on the spasmolytic and analgesic effects of 4,4-diphenyl-N-isopropyl-cyclohexylamine-hydrochloride (pramiverine, Sistalgin), metamizole and a combination of both active principles in equal dose ratio (1 : 1000). The results demonstrated that pramiverine showed a potent spasmolytic effect which was potentiated by the combination with metamizole, and that the positive analgesic effect of metamizole was fully displayed in the combination with pramiverine, but that for pramiverine alone no analgesic effect was detected.
D000632:Aminopyrine / Q000031:analogs & derivatives*; D000700:Analgesics; D000818:Animals; D001559:Benzhydryl Compounds / Q000494:pharmacology; D003514:Cyclohexylamines / Q000494:pharmacology*; D004177:Dipyrone / Q000494:pharmacology*; D004338:Drug Combinations; D004357:Drug Synergism; D005769:Gastrointestinal Motility / Q000187:drug effects; D008297:Male; D051379:Mice; D010276:Parasympatholytics; D051381:Rats
D000700:Analgesics; D001559:Benzhydryl Compounds; D003514:Cyclohexylamines; D004338:Drug Combinations; D010276:Parasympatholytics; D000632:Aminopyrine; D004177:Dipyrone
Tierexperimentelle Untersuchungen auf spasmolytische und analgetische Wirkungen von Pramiverin, Metamizol sowie einer Kombination beider Substanzen