title: Influence of x-rays on the rate of accumulation of 131I in the thyroid of guinea pigs in the initial stage of radiation disease.
abstract: The influence of single, total body X-ray irradiation with 500 and 1500 R on 131 uptake in the thyroids of guinea pigs in the initial stage of radiation disease was studied. Radioactivity of the thyroid was measured 1, 3, 6, 24 and 48 h after i.p. injection of 131I, I.E. 69, 71, 74, 92 and 116 H after the and of X-ray irradiation. Sixty-nine and 71 h after the and of X-irradiation, accumulation of 131I was higher in the thyroids of  male and female irradiated guinea pigs in comparison with controls. At 75 h after X-irradiation i.e 6 h after administration of 131I, a drop in the iodine content of the thyroid occurred, which lasted up to 48 h. The drop in 131I uptake by the thyroid was particularly significant at 92 h after irradiation of male and female guinea pigs i.e. at 24 h after introduction of the isotope, in comparison with the controls.
mesh_terms: D000818:Animals; D004307:Dose-Response Relationship, Radiation; D005260:Female; D006168:Guinea Pigs; D007457:Iodine Radioisotopes / Q000378:metabolism*; D008297:Male; D011833:Radiation Injuries, Experimental / Q000378:metabolism*; D012737:Sex Factors; D013961:Thyroid Gland / Q000378:metabolism* / Q000528:radiation effects; D013997:Time Factors
chemical_list: D007457:Iodine Radioisotopes