[Fab fragments of immunoglobulins: specific activity and reactivity. II. Comparative study of the anaphylactogenic properties of anti-encephalitic gamma-globulin and Fab-fragments isolated from it].
With the aid of the active anaphylactic reaction a comparative study was carried out of the reactogenic (anaphylactogenic) properties of gamma-globulin against tick-borne encephalitis from horse serum and of Fab-fragments isolated from it by gel-filtration. There proved to be statistically significant differences in the reactogenic properties of the preparations under study on condition of their separate use (reactogenic property of Fab-fragments was four times less than that of gamma-globulin). In case of a combined use of Fab-fragments and gamma-globulin, i.e. administration of the former after the sensitization of experimental animals with the latter, reactogenicity level of the two biopreparations proved to be practically the same.
D000707:Anaphylaxis / Q000276:immunology*; D000818:Animals; D000914:Antibodies, Viral; D004675:Encephalitis, Tick-Borne / Q000276:immunology; D006168:Guinea Pigs; D007140:Immunoglobulin Fab Fragments
D000914:Antibodies, Viral; D007140:Immunoglobulin Fab Fragments
Fab-fragmenty immunoglobulinov:  izuchenie spetsificheskoĭ aktivnosti i reaktogennosti.  Soobschenie.  II.  Sravnitelnoe izuchenie anafilaktogennykh svoĭstv protivoèntsefalitnogo gamma-globulina i vydelennykh iz nego Fab-fragmentov