title: [The clinical significance of granulocyte colonies in bone marrow cultures].
abstract: The culture system for in vitro evaluation of "colony forming units - culture (CFU-c)" is briefly outlined. This method offers a new approach to studies of proliferation and differentiation of hemopoietic progenitor cells, especially in disorders of granulopoiesis. From available published data it is evident that quantitation of CFU-c is also an indicator of diagnostic and prognostic value for assessment of various types of leukemia. The CFU-c assay has furthermore been introduced to test the viability and proliferating capacity of cryopreserved bone marrow, especially with a view to possible transfusion of stored autologous bone marrow as an adjuvant to cytostatic therapy.
mesh_terms: D001853:Bone Marrow; D001854:Bone Marrow Cells; D002454:Cell Differentiation; D002455:Cell Division; D002478:Cells, Cultured; D006098:Granulocytes; D006801:Humans; D007938:Leukemia / Q000175:diagnosis*; D007962:Leukocytes
vernacular_title: Zur klinischen Bedeutung des Nachweises von Granulozytenkolonien in Knochenmark-kulturen