Exogenous hypercortisolism and epididymal fat cell count in young rats.
The influence of two different grades of exogenous hypercortisolism on body weight, epididymal fat pad weight and the total number of fat cells in epididymal fat pads was investigated in young, growing rats. Cortisol, 4-5 mg/kg/day orally from the 7th to the 9th week, reduced body weight gain, whereas epididymal fat pad weight and fat cell content did not differ from those of the control rats. Cortisone acetate, 2.5 mg per 100 g, given subcutaneously for 2 weeks to rats 4-11 week of age caused in the young rat (4-6 weeks) a partial inhibition of the normal increase in body weight, whereas in the young-adult rat (6 weeks and older) an actual decrease of body weight was seen. At both dose levels and - with respect to the higher dose level- in all age groups studied, the weight and fat cell content of the epididymal fat pad were not changed by the cortisone (cortisol) treatment.
D000273:Adipose Tissue / Q000166:cytology / Q000187:drug effects*; D000818:Animals; D001835:Body Weight / Q000187:drug effects; D003348:Cortisone / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D004822:Epididymis; D006854:Hydrocortisone / Q000494:pharmacology*; D008297:Male; D051381:Rats
D003348:Cortisone; D006854:Hydrocortisone