Improvement of biliary excretion of ioglycamide by pretreatment with phenobarbital.
The influence of a phenobarbital pretreatment on the distribution and biliary excretion of Ioglycamide was studied in 6 experiments in the anaesthetized minipig. The phenobarbital pretreatment led to a significant increase of the biliary transportmaximum and the biliary concentration of Ioglycamide. A detailed analysis suggests a phenobarbital induced stimulation of the hepatocellular excretion. The applicability of a pretreatment with phenobarbital in order to improve the opacification of the biliary system during x-ray-examinations with Ioglycamide is discussed.
D000818:Animals; D001646:Bile / Q000378:metabolism*; D002765:Cholecystography / Q000379:methods; D007463:Iodobenzoates; D007471:Ioglycamic Acid / Q000378:metabolism; D010634:Phenobarbital / Q000494:pharmacology*; D013552:Swine
D007463:Iodobenzoates; D007471:Ioglycamic Acid; D010634:Phenobarbital