[Dependence of the toxicity of the antineoplastic antibiotics rubomycin and carminomycin, on the age and sex of white mice and rats].
Karminomycin was more toxic with respect to 2-6 week mice than to adult animals when administered both intravenously or orally. 5-6 week rats were more stable than adult animals to the effect of karminomycin administered intravenously or orally. Significant species sensitivity to karminomycin was noted. When administered intravenously karminomycin administered intravenously was 2 times more toxic as compared to the oral use in the experiments with adult mice and 23 times more toxic in the experiments with adult rats. LD10 and LD50 of rubomycin administerean in adult animals. LD50 of karminomycin and rubomycin administered intravenously to adult female mice was somewhat lower than that for adult male mice.
D000284:Administration, Oral; D000367:Age Factors; D000818:Animals; D000903:Antibiotics, Antineoplastic / Q000633:toxicity*; D002360:Carubicin / Q000633:toxicity*; D003630:Daunorubicin / Q000633:toxicity*; D005260:Female; D007275:Injections, Intravenous; D007928:Lethal Dose 50; D008297:Male; D051379:Mice; D051381:Rats; D012737:Sex Factors; D013045:Species Specificity
D000903:Antibiotics, Antineoplastic; D002360:Carubicin; D003630:Daunorubicin
Zavisimost' toksichnosti protivoopukholevykh antibiotikov rubomitsina i karminomitsina ot vozrasta i poly belykh mysheĭ i krys