Chromatin structure: a property of the higher structures of chromatin and in the time course of its formation during chromatin replication.
The action of a number of enzymes and metals on one nuclear preparation were interpreted in terms of the existence of a fragile but highly DNAase-I resistant feature of chromatin superstructure. The generation of this DNAase-I resistance feature of chromatin was then followed during normal DNA synthesis in the regenerating rat liver by following the disappearance of a transitory DNAase-I susceptible state. This transitory, DNAase-I susceptible state appears to be extremely similar to the post-synthetic, DNAase-I susceptible state that has been described in He La32.
D000818:Animals; D002118:Calcium / Q000494:pharmacology; D002467:Cell Nucleus; D002843:Chromatin / Q000648:ultrastructure*; D004261:DNA Replication; D003851:Deoxyribonucleases / Q000378:metabolism; D004720:Endonucleases / Q000378:metabolism; D005260:Female; D008099:Liver / Q000648:ultrastructure; D008115:Liver Regeneration; D008836:Micrococcal Nuclease / Q000378:metabolism; D008970:Molecular Weight; D051381:Rats; D014357:Trypsin / Q000378:metabolism
D002843:Chromatin; D003851:Deoxyribonucleases; D004720:Endonucleases; D008836:Micrococcal Nuclease; D014357:Trypsin; D002118:Calcium