[Influence of a pressure agent on blood concentrations of glucose, lactate, pyruvate and free fatty acids (author's transl)].
In 34 unselected patients blood concentrations of glucose, lactate, pyruvate and free fatty acids (FFA) were determined after i.v. injection of a pressure agent containing theophylline esterified with norephedrine and theophylline esterified with norepinephrine (Akrinor) with and without beta-adrenergic blockade. After Akrinor a significant increase of FFA concentration of 32% is observed, which can be abolished by beta-receptor blocking agents. Our findings indicate that the Akrinor-induced lipolysis is mainly due to a direct sympathomimetic effect on the beta-receptors of adipose tissue. there are only slight effects on carbohydrate metabolism (decrease of pyruvate concentration, increase of lactate/pyruvate ratio) which are not influenced by beta-receptor blockade. According to our results there are important metabolic differences between Akrinor and the classical catecholamines.
D001786:Blood Glucose / Q000378:metabolism*; D004338:Drug Combinations; D005021:Ethylamines / Q000494:pharmacology; D005230:Fatty Acids, Nonesterified / Q000097:blood*; D006801:Humans; D007773:Lactates / Q000097:blood*; D009638:Norepinephrine / Q000494:pharmacology*; D011433:Propranolol / Q000494:pharmacology; D011773:Pyruvates / Q000097:blood*; D013806:Theophylline / Q000031:analogs & derivatives* / Q000494:pharmacology
D001786:Blood Glucose; D004338:Drug Combinations; D005021:Ethylamines; D005230:Fatty Acids, Nonesterified; D007773:Lactates; D011773:Pyruvates; D011433:Propranolol; D013806:Theophylline; D009638:Norepinephrine
Einfluss einer blutdruckwirksamen Substanz auf die Stoffwechselsubstrate im Blut bzw. Serum