A new antibiotic,, asukamycin, produced by Streptomyces.
Asukamycin, a new antibiotic, has been isolated from the culture broth of a streptomycete designated as Streptomyces nodosus subsp. asukaensis. The antibiotic inhibits the growth of Gram-positive bacteria including Nocardia asteroides. The empirical formula of antibiotic asukamycin has been proposed as C29H22N2O9 (M.W. 542). An acute toxicity of the antibiotic in mice is LD50 48.5 mg/kg by intraperitoneal injection and it has no effect on mice when it was administered by 450 mg/kg per os.
D000818:Animals; D000900:Anti-Bacterial Agents / Q000032:analysis / Q000096:biosynthesis / Q000494:pharmacology; D001419:Bacteria / Q000187:drug effects; D055598:Chemical Phenomena; D002621:Chemistry; D002645:Chickens; D003048:Coccidiosis / Q000188:drug therapy; D005285:Fermentation; D005658:Fungi / Q000187:drug effects; D007928:Lethal Dose 50; D051379:Mice; D008970:Molecular Weight; D013302:Streptomyces / Q000166:cytology / Q000378:metabolism*
D000900:Anti-Bacterial Agents