Freeze-etching studies on ultrastructural changes of endothelial cells in the thyroid of normal, TSH-treated and thyradin-treated mice.
Freeze-etching images of the capillary endothelium in the thyroid of normal, TSH-treated and Thyradin (powdered thyroid)-treated mice were examined. Numerous pores represent vesicular stomata or fenestrations. The number of the pores and their population density are increased in TSH-treated mice, and decreased in Thyradin-treated animals. In addition, the width of the parajunctional zone and of the flat ray free from endothelial pores is smaller in TSH-treated mice and larger in Thyradin-treated animals. These facts indicate that the number of endothelial pores changes according to the functional activity of the gland.
D000818:Animals; D002196:Capillaries / Q000648:ultrastructure; D002462:Cell Membrane / Q000648:ultrastructure; D004727:Endothelium / Q000648:ultrastructure; D005613:Freeze Etching; D008297:Male; D051379:Mice; D013962:Thyroid (USP) / Q000494:pharmacology*; D013961:Thyroid Gland / Q000187:drug effects / Q000648:ultrastructure*; D013963:Thyroid Hormones / Q000494:pharmacology*; D013972:Thyrotropin / Q000494:pharmacology*
D013962:Thyroid (USP); D013963:Thyroid Hormones; D013972:Thyrotropin