Metabolism of N-nitrosohexamethyleneimine.
The metabolism of [2-14C]N-nitrosohexamethyleneimine in male MRC-Wistar rats was studied and some of the major urinary metabolites were identified. The extent of total oxidation to 14CO2 was 18.1% in 24 hours and radioactivity incorporation was observed in various tissues; that in the liver was the highest. Analysis of urine after 24 hours showed that 36.7% of the radioactivity administered was excreted by this route, with a minimum of 11 products present. Hexamethyleneimine (HX), epsilon-caprolactam, epsilon-aminocaproic acid, and 6-aminocaprohydroxamic acid were the identified metabolites. Of the remaining products, two appeared to result from HX metabolism and one was a glucuronide conjugate. No parent compound was found.
D015119:Aminocaproic Acid / Q000378:metabolism; D000818:Animals; D001381:Azepines / Q000378:metabolism / Q000652:urine; D002208:Caproates / Q000378:metabolism; D002209:Caprolactam / Q000378:metabolism; D002245:Carbon Dioxide / Q000378:metabolism; D055598:Chemical Phenomena; D002621:Chemistry; D006900:Hydroxylation; D008099:Liver / Q000378:metabolism; D008297:Male; D009602:Nitrosamines / Q000378:metabolism* / Q000652:urine; D051381:Rats
D001381:Azepines; D002208:Caproates; D009602:Nitrosamines; D002245:Carbon Dioxide; D002209:Caprolactam; C002742:N-nitrosoperhydroazepine; D015119:Aminocaproic Acid