title: The effect of dextranomer (Debrisan) on hand burns. A preliminary report on a new method in the treatment of hand burns.
abstract: Dextranomer (Debrisan, Pharmacia, Uppsala, Sweden) is synthetized by cross-linking of dextran chains with epichlorohydrin. It is an insoluble hydrophilic substance which is suitable for topical treatment of secreting wounds, such as burns. Thirteen patients with 17 burned hands were treated. The result of the treatment - decrease in pain, healing time and improved hand function - was registered clinically. No crust was formed. The risk of permanent restriction in range of movements decreased, since the treated hands were soft and mobile throughout the entire period of treatment. All hands treated recovered full mobility. Physiotherapy could be performed daily. No infection appeared because exudate and bacteria were continuously removed from the treated area. Pain rapidly decreased. No side reactions were observed.
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D002056:Burns / Q000188:drug therapy*; D002728:Chlorohydrins / Q000627:therapeutic use*; D003911:Dextrans / Q000627:therapeutic use*; D004341:Drug Evaluation; D004811:Epichlorohydrin / Q000627:therapeutic use*; D006225:Hand / Q000503:physiopathology; D006230:Hand Injuries / Q000188:drug therapy*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010146:Pain; D014945:Wound Healing / Q000187:drug effects*
chemical_list: D002728:Chlorohydrins; D003911:Dextrans; D004811:Epichlorohydrin