title: A comparison of various routes of Newcastle Disease vaccination at one day of age.
abstract: Groups of 100 one-day-old chicks with moderate levels of maternal antibody were vaccinated with the B1 strain of Newcastle disease virus subcutaneously, intratracheally, intraocularly or by aerosol or were left unvaccinated. Certain of these groups were revaccinated at 9 or 9 and 28 days or at 14 or 14 and 28 days with the LaSota strain of Newcastle disease virus. Vaccination by all routes at one day of age resulted in an antibody response and increased resistance to challenge. The most effective route was by aerosol followed by the intraocular method. Intratracheal administration or subcutaneous inoculation led to a marginal response. Aerosol administration at 9 or 9 and 28 days or at 14 or 14 and 28 days gave adequate antibody responses and resistance to challenge.
mesh_terms: D000336:Aerosols; D000367:Age Factors; D000818:Animals; D000917:Antibody Formation; D005123:Eye; D007267:Injections; D007279:Injections, Subcutaneous; D008297:Male; D009521:Newcastle Disease / Q000276:immunology / Q000517:prevention & control*; D009522:Newcastle disease virus / Q000276:immunology*; D014132:Trachea; D014611:Vaccination / Q000379:methods / Q000662:veterinary; D014765:Viral Vaccines / Q000008:administration & dosage*
chemical_list: D000336:Aerosols; D014765:Viral Vaccines