title: Pulmonary aspiration of gastric contents.
abstract: A retrospective analysis of 50 patients who had been observed to aspirate gastric contents was performed to define better the course of patients with this syndrome. The patients invariably had a disturbance of consciousness, most commonly due to sedative drug overdose or general anesthesia. The onset of clinical signs occurred prompty after aspiration and tended to be similar in all patients, irrespective of their subsequent course or outcome. These findings usually included fever, tachypnea, diffuse rales, and serious hypoxemia. Cough, cyanosis, wheezing, and apnea were each seen in approximately one third of the cases. Apena, shock, and early severe hypoxemia were particularly ominous events. Initial roentgenograms revealed diffuse or localized alveolar infiltrates, which progressed during the next 24 to 36 hours. Subsequent clinical courses followed 3 patterns: 12 per cent of the patients died shortly after aspiration; 62 per cent had rapid clinical and radiologic improvement, with clearing, on average, within 4.5 days; 26 per cent demonstrated rapid improvement, but then had clinical  and radiographic progression associated with recovery of bacterial pathogens from the sputum and a fatal outcome in more than 60 per cent. Treatment from the outset by adrenocortical steroids or antimicrobial agents had no demonstrable effect on the outcome. The clinical features of aspiration of gastric contents are characteristic and distinguish it from other forms of aspiration-related lung disease.
mesh_terms: D001049:Apnea / Q000209:etiology; D001424:Bacterial Infections / Q000188:drug therapy / Q000209:etiology; D006801:Humans; D000860:Hypoxia / Q000209:etiology; D007442:Intubation, Intratracheal; D008168:Lung / Q000503:physiopathology*; D010406:Penicillins / Q000627:therapeutic use; D011015:Pneumonia, Aspiration / Q000150:complications / Q000628:therapy; D012121:Respiration, Artificial; D012769:Shock / Q000209:etiology; D013577:Syndrome; D013754:Tetracyclines / Q000627:therapeutic use
chemical_list: D010406:Penicillins; D013754:Tetracyclines