[Experimental investigations in regard to the optimal stimulation of lecithin synthesis in the fetal lung via glucocorticoids (author's transl)].
On the basis of curves illustrating the effects of dosage on experimental animals, it was shown that glucocorticoids inhibit as well as stimulate lecithin synthesis in the fetal lung. Equivalent doses of corticoids produce comparable results. It was established that the concentration necessary to produce an optimal stimulation of lecithin synthesis was 0.5 to 2.0 mg/kg body weight.
D000818:Animals; D002794:Choline / Q000378:metabolism; D003907:Dexamethasone / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D005260:Female; D005938:Glucocorticoids / Q000494:pharmacology*; D006854:Hydrocortisone / Q000494:pharmacology; D066298:In Vitro Techniques; D008168:Lung / Q000187:drug effects / Q000196:embryology* / Q000378:metabolism; D008775:Methylprednisolone / Q000008:administration & dosage / Q000494:pharmacology; D010713:Phosphatidylcholines / Q000096:biosynthesis*; D011247:Pregnancy; D011663:Pulmonary Surfactants / Q000096:biosynthesis*; D051381:Rats
D005938:Glucocorticoids; D010713:Phosphatidylcholines; D011663:Pulmonary Surfactants; D003907:Dexamethasone; D002794:Choline; D006854:Hydrocortisone; D008775:Methylprednisolone
Tierexperimentelle Untersuchungen zur Frage der optimalen Synthesestimulierung des Lezithins in der fetalen Lunge durch Glukokortikoide