HLA antigens and corticosteroid response.
Compared with normal individuals, patients with primary open-angle glaucoma have increased prevalences of HLA-B12 and B7 antigens and are more responsive to glucocorticoids. Lymphocytes from both ocular normotensive and glaucomatous individuals with the HLA-B12 antigen require significantly (P less than .02) lower concentrations of prednisolone to inhibit phytohemagglutinin-induced transformation.
D005901:Glaucoma / Q000276:immunology; D006680:HLA Antigens / Q000032:analysis; D006801:Humans; D008213:Lymphocyte Activation / Q000187:drug effects*; D011239:Prednisolone / Q000008:administration & dosage / Q000494:pharmacology*
D006680:HLA Antigens; D011239:Prednisolone