[Effects of drugs on leukocyte migration].
The effects of various drugs on chemotaxis of polymorphonuclear leukocytes (PMN's) in vitro have been studied. Response of rabbit PNM's in vitro to the chemotaxis was found to be suppressed by hydrocortisone succinate, chloroquine hydrochloride, cytochalasin B, colchicine and dibutyl cyclic AMP. On the other hand, 8-bromo-cyclic GMP enhanced the chemotaxis of PMN's.
D000818:Animals; D002633:Chemotaxis / Q000187:drug effects*; D002738:Chloroquine / Q000494:pharmacology; D003078:Colchicine / Q000494:pharmacology; D003571:Cytochalasin B / Q000494:pharmacology; D006854:Hydrocortisone / Q000494:pharmacology; D066298:In Vitro Techniques; D007962:Leukocytes / Q000187:drug effects*; D009504:Neutrophils / Q000187:drug effects; D009712:Nucleotides, Cyclic / Q000494:pharmacology; D011817:Rabbits
D009712:Nucleotides, Cyclic; D003571:Cytochalasin B; D002738:Chloroquine; D003078:Colchicine; D006854:Hydrocortisone