title: Regulation of the immune system by synthetic polynucleotides. VI. Amplification of the immune response in young and aging mice.
abstract: Model systems for study of the action of adjuvants in immunodeficient states were developed in 10- to 14-day-old BALB/aj mice and aging BALB/aj mice (12 to 16 months). With sheep red blood cells as antigen polyadenylicpolyuridylic acid complexes (poly A:U) were found to be stimulatory in both the neonatal and aging mice. The effect of poly A:U was similar to that seen when 5 X 10(6) thymocytes from immunologically mature mice were given with antigen. Cell-free supernatant fluids induced by incubation of poly A:U with thymocytes likewise were capable of restoring the number of antibody-forming cells to normalcy in aging mice.
mesh_terms: D000276:Adjuvants, Immunologic; D000375:Aging; D000818:Animals; D000917:Antibody Formation; D000921:Antibody-Producing Cells; D000941:Antigens; D004912:Erythrocytes / Q000276:immunology; D051379:Mice; D008807:Mice, Inbred BALB C; D011063:Poly A-U / Q000276:immunology*
chemical_list: D000276:Adjuvants, Immunologic; D000941:Antigens; D011063:Poly A-U