Endrocrine factors and the growth and spread of B16 melanoma.
B16 melanomas grew more slowly in female than in male syngeneic C57BL/6J mice. After oophorectomy, the growth rate was similar to that in normal and castrated male mice and was not altered in pregnant mice. The growth in vitro was similar in the presence of serum from normal and castrated male and female mice.
D000311:Adrenal Glands / Q000502:physiology; D000818:Animals; D002478:Cells, Cultured; D005260:Female; D012739:Gonadal Steroid Hormones / Q000502:physiology*; D007866:Leg; D008297:Male; D008545:Melanoma / Q000473:pathology / Q000503:physiopathology*; D051379:Mice; D008810:Mice, Inbred C57BL; D009362:Neoplasm Metastasis; D009374:Neoplasms, Experimental / Q000473:pathology / Q000503:physiopathology; D010053:Ovary / Q000502:physiology; D011247:Pregnancy; D013737:Testis / Q000502:physiology
D012739:Gonadal Steroid Hormones