title: Platelet aggregation inhibitors. II - N-heterocyclic aldoxime methiodides (1).
abstract: On the basis of an hypothesis according to which suitable nucleophilic agents may convert adenosine diphosphate (ADP) into adenosine monophosphate (AMP) and adenosine, well known inhibitors of ADP-induced platelet aggregation, some N-heterocyclic aldoxime methiodides were tested as inhibitors of ADP-induced rabbit platelet aggregation. Several 1-aryl-2-hydroxyiminomethly-3-methylimidazolium iodides significantly inhibit in vitro and in vivo-in vitro ADP-induced rabbit platelet aggregation.
mesh_terms: D000244:Adenosine Diphosphate; D000818:Animals; D006571:Heterocyclic Compounds / Q000494:pharmacology*; D010091:Oximes / Q000494:pharmacology*; D010974:Platelet Aggregation / Q000187:drug effects*; D011817:Rabbits
chemical_list: D006571:Heterocyclic Compounds; D010091:Oximes; D000244:Adenosine Diphosphate