Retarded incorporation of [14C]mannose into thyroglobulin of human thyrotoxic thyroid glands.
In vitro studies using thyroid slices from human non-toxic goitres and from thyrotoxic glands show retarded incorporation of [14C]mannose into the 19S protein of thyrotoxic glands. This was not found using [14C]galactose with thyrotoxic glands or using either labelled sugar with slices from non-toxic goitres. Experiments with thyroid tissue from rats on a variety of treatment regimes such as iodine supplements, carbimazole alone or with iodine supplements did not show this differential delay of [14C]mannose incorporation. This suggests that there may be some abnormality of carbohydrate incorporation into thyroglobulin in thyrotoxicosis.
D000818:Animals; D002231:Carbimazole / Q000494:pharmacology; D005690:Galactose / Q000378:metabolism; D006042:Goiter / Q000378:metabolism; D006801:Humans; D006980:Hyperthyroidism / Q000378:metabolism*; D066298:In Vitro Techniques; D007455:Iodine / Q000378:metabolism; D008358:Mannose / Q000378:metabolism*; D051381:Rats; D013954:Thyroglobulin / Q000096:biosynthesis*; D013961:Thyroid Gland / Q000378:metabolism
D002231:Carbimazole; D013954:Thyroglobulin; D007455:Iodine; D008358:Mannose; D005690:Galactose