[Effect of general anesthesia on complement. Effect of the atmosphere in the operating room on the immune response of anesthesiologists].
Variations in the C3 and C4 fractions of complement were studied in 15 patients who underwent surgery with either spinal anesthesia (5 cases) or general anesthesia using nitruos oxyde and a halogen compound (10 cases). Little peroperative variation was observed. An increase in C4 was observed in all cases postoperatively. Only a slight increase in C3 was observed after spinal anesthesia. The immune response of anesthetists exposed to halothane was investigated using PHA-induced lymphocyte stimulation (normal in males, elevated in females) and lymphocyte transformation to halothane and its metabolites (no evidence of allergy was observed).
D000393:Air Pollutants; D000395:Air Pollutants, Occupational; D000768:Anesthesia, General; D000776:Anesthesiology; D003165:Complement System Proteins; D004737:Enflurane / Q000494:pharmacology*; D005260:Female; D006221:Halothane / Q000494:pharmacology*; D006801:Humans; D007109:Immunity / Q000187:drug effects*; D008213:Lymphocyte Activation / Q000187:drug effects; D008297:Male; D008738:Methyl Ethers / Q000494:pharmacology*; D009873:Operating Rooms; D012737:Sex Factors
D000393:Air Pollutants; D000395:Air Pollutants, Occupational; D008738:Methyl Ethers; D003165:Complement System Proteins; D004737:Enflurane; D006221:Halothane
Action de l'anesthésie générale sur le complément. Effets de l'atomosphére de la salle d'opération sur la réponse immunitaire des anesthésiologistes