Toxicity and tissue residues from diphenylhydantoin fed to chickens.
Within three experiments with broiler-type crossbred chickens, diphenlyhydantoin (DPH) was administered via the diet at levels ranging from 10 to 2500 mg./kg. Feed intake and body weight gain were adversely affected by levels of 100 mg./kg. or higher. A hemorrhagic syndrome occurred in 16 percent of the chickens fed 100-1000 mg./kg. and 33 percent of those fed 2500 mg./kg. Twenty percent of the chickens fed 1000 mg./kg. were anemic; none of those receiving 250 mg./kg. were anemic. Other toxic manifestations included neurological side effects of a lethargic stupor, excitability to a disturbance, or a characteristic condition referred to as "head under." Pair-feeding experiments revealed thatlowered feed intake was not responsible for any of the clinical signs. All of the toxicity signs were reversible in 3 to 4 weeks following withdrawal of DPH. Muscle samples contained 2.5 to 11.4 mcg. DPH/g. at drug levels of 1000 and 2500 mg. DPH/kg. diet. Dose-response curves revealed that plasma, adipose, kidney and liver had levels which were, respectively, 1.05, 1.51, 2.19, and 2.85 times those of muscle.
D000273:Adipose Tissue / Q000378:metabolism; D000821:Animal Feed; D000818:Animals; D001835:Body Weight; D002645:Chickens / Q000378:metabolism*; D005260:Female; D006470:Hemorrhage / Q000139:chemically induced / Q000401:mortality / Q000662:veterinary; D008099:Liver / Q000378:metabolism; D008297:Male; D009132:Muscles / Q000378:metabolism; D010672:Phenytoin / Q000378:metabolism / Q000633:toxicity*; D011201:Poultry Diseases / Q000139:chemically induced* / Q000401:mortality
D010672:Phenytoin