Radiopaque contrast media. XXXIX - Metabolism of iopronic acid by rat liver microsomes: characterization and identification of the metabolites.
The metabolism of iopronic acid, 2(2[(3-acetamido-2,4,6-triiodophenoxy)ethoxy]methyl)butyric acid, was studied in vitro using rat liver microsomes as enzyme source. By means of solvent extraction, T.L.C., H.P.L.C. and mass spectrometry, the hydroxyethyl (3-acetamido-2,4,6-triiodophenyl) ether and the 3-acetamido-2,4,6-triiodophenoxyacetic acid have been identified as the metabolities of the parent drug. No deiodinated metabolites were found. The probable mechanism of the in vitro formation of the metabolites is discussed.
D000818:Animals; D002219:Carbamates / Q000032:analysis / Q000378:metabolism; D003287:Contrast Media / Q000032:analysis / Q000378:metabolism*; D007462:Iodobenzenes / Q000032:analysis / Q000378:metabolism*; D008297:Male; D013058:Mass Spectrometry; D008862:Microsomes, Liver / Q000378:metabolism*; D051381:Rats
D002219:Carbamates; D003287:Contrast Media; D007462:Iodobenzenes