Catecholamine levels in penicillin-induced epileptic focus of the cat cerebral cortex.
In 25 cats an unilateral epileptic focus was produced by intracortical injection of potassium benzyl penicillin and on the other hemisphere, sham-operation was done by injection of the same volume of saline solution without penicillin. Catecholamine analysis was performed for each hemisphere separately. In a second series of 15 cats, the effect of catecholamines and of 1-DOPA on penicillin-induced spike activity was examined. In the first and second stage of propagation of penicillin-induced spikes, dopamine and norepinephrine significantly decreased in the focus. In the third stage no differences existed. The penicillin-induced spike activity was reduced as well by the topical application of dopamine as of 1-DOPA, whilst no inhibitory effect was observed in the topical application of norepinephrine.
D000818:Animals; D002395:Catecholamines / Q000378:metabolism*; D002415:Cats; D002540:Cerebral Cortex / Q000378:metabolism*; D004298:Dopamine / Q000378:metabolism / Q000494:pharmacology; D007980:Levodopa / Q000494:pharmacology; D009638:Norepinephrine / Q000378:metabolism / Q000494:pharmacology; D010406:Penicillins; D012640:Seizures / Q000139:chemically induced / Q000378:metabolism*
D002395:Catecholamines; D010406:Penicillins; D007980:Levodopa; D004298:Dopamine; D009638:Norepinephrine