[Rise in neutrophils after hydrocortisone seen as bone marrow reserve mass. Dependency on spleen size].
In 25 patients with a wide range of postmitotic marrow neutrophil mass a linear relationship was observed between the number of postmitotic marrow neutrophils and the rise of blood neutrophils after intravenous injection of 3 mg hydrocortisone/kg. Related to marrow neutrophil cellularity, the response curve was significantly higher in 10 splenectomized patients but greatly depressed in 10 patients with splenomegaly.
D001853:Bone Marrow / Q000187:drug effects*; D001854:Bone Marrow Cells; D006801:Humans; D006854:Hydrocortisone / Q000494:pharmacology*; D009504:Neutrophils / Q000187:drug effects; D013154:Spleen / Q000503:physiopathology*; D013156:Splenectomy; D013163:Splenomegaly / Q000503:physiopathology
D006854:Hydrocortisone
Neutrophilenanstieg nach Hydrocortison als Mass der Knochenmarkreserve. Abhängigkeit von der Milzgrösse