title: Localization of the Bf locus within the HLA region. Report on an informative family and critical evaluation of available data on Bf mapping.
abstract: Since the estimation of recombination fractions is only an arbitrary means to map genetic loci on chromosomal regions, family studies of cases with informative cross-overs within the region in question are of decisive importance. This paper reports the study of a family with a HLA-B to HLA-D cross-over which is informative in the Bf system. The possible reasons for conflicting published data on Bf gene mapping are discussed.
mesh_terms: D002874:Chromosome Mapping; D002906:Chromosomes, Human, 6-12 and X; D003434:Crossing Over, Genetic; D006680:HLA Antigens; D006649:Histocompatibility Antigens; D006801:Humans; D011414:Properdin; D011995:Recombination, Genetic
chemical_list: D006680:HLA Antigens; D006649:Histocompatibility Antigens; D011414:Properdin