[Concentration of free glutamine and glutaminase activity in the gastric mucosa of patients with precancerous diseases and cancer of the stomach].
Free glutamine content and phosphate-dependent glutaminase activity were studied in the biopsy specimens from the tissue of ulcer, polyps, carcinoma and the surrounding gastric mucosa of patients with precancerous diseases and carcinoma of the stomach. The glutamine content in carcinoma was not significantly different from that in the normal gastric mucosa. The glutamine level in the gastric mucosa remote from the tumour was considerably higher than normal. In case of polyposis of the stomach glutamine was present in the polyps and absent in the remote gastric mucosa. A marked glutaminase activity was revealed in the carcinoma of the stomach, but its level did not differ from the normal or in the case of precancerous diseases.
D005753:Gastric Mucosa / Q000378:metabolism*; D005756:Gastritis / Q000201:enzymology / Q000378:metabolism; D005972:Glutaminase / Q000378:metabolism*; D005973:Glutamine / Q000378:metabolism*; D006801:Humans; D011127:Polyps / Q000201:enzymology / Q000378:metabolism; D011230:Precancerous Conditions / Q000201:enzymology / Q000378:metabolism*; D013274:Stomach Neoplasms / Q000201:enzymology / Q000378:metabolism*; D013276:Stomach Ulcer / Q000201:enzymology / Q000378:metabolism
D005973:Glutamine; D005972:Glutaminase
Soderzhanie svobodnogo gliutamina i aktivnost' gliutaminazy v slizistoĭ obolochke zheludka u bol'nykh s predopukholevymi zabolevaniiami i rakom zheludka