title: [Mutagenic effect of different types of irradiation on the sex cells of male mice. X. Frequency of recessive lethal mutations and reciprocal translocations in the spermatogonia of mice subjected to fractional gamma-irradiation].
abstract: The frequency of recessive lethal mutations and reciprocal translocations was investigated in spermatogonia of CBA male mice which were thrice gamma-irradiated at doses of 300 r with 28 days intervals. The rate of induced recessive lethals was estimated 1) by comparison of embryos survival between the irradiated and control groups in mating of the F1 males with their daughters, and 2) by estimation the frequency of males heterozygotes for recessive lethals in the first generation. In the first case the frequency of recessive lethals was 2,8 +/- 0,8-10(-4) per r per gamete (for the pre- and post-implantation death) and 1,6 +/- 0,1-10(-4) per r per gamete (for the pre- and post-implantation death) and 1,6 +/- 0,1-10(-4) per r per gamete in the second case. The frequency of heterozygotes for reciprocal translocations in the first generations of males was 3,1 +/- 0,9-10(-5) per r per gamete.
mesh_terms: D000818:Animals; D002869:Chromosome Aberrations; D003037:Cobalt Radioisotopes; D005720:Gamma Rays; D005804:Genes, Lethal; D005808:Genes, Recessive; D008297:Male; D051379:Mice; D008808:Mice, Inbred CBA; D009154:Mutation; D013093:Spermatogonia / Q000528:radiation effects*; D013094:Spermatozoa / Q000528:radiation effects*; D014178:Translocation, Genetic
chemical_list: D003037:Cobalt Radioisotopes
vernacular_title: Mutagennyĭ éffekt izlucheniĭ raznykh vidov v polovykh kletkakh samtsov mysheĭ. Soobshchenie X. Chastota retsessivnykh letal'nykh mutatsiĭ i retsiproknykh translokatsiĭ v spermatogoniiakh mysheĭ, podvergshikhsia fraktsionirovannomu gamma-oblucheniiu