Measurements of oxygen tension from the canine gastric mucosa under the influence of vasoactive and acid stimulating agents and following vagotomy. Implications on the pathophysiology of peptic ulceration.
By the use of a multiwire platinum electrode mucosal tissue pO2 from the canine gastric antrum is continuously recorded. Injection of norepinephrine causes a short, steep fall of mucosal pO2, naftidrofuryl elevates mucosal pO2 for several minutes in spite of reduced arterial blood pressure, pentagastrin produces a biphasic response, a temporary rise of mucosal pO2 is followed by a longer lasting decrease, vagotomy causes a considerable and more persistent drop of mucosal pO2. These experimental findings are discussed in their possible relations to the clinical problem of ulcer formation and therapy of gastroduodenal bleeding.
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D004285:Dogs; D005260:Female; D005663:Furans / Q000494:pharmacology*; D005753:Gastric Mucosa / Q000503:physiopathology*; D008297:Male; D009257:Nafronyl / Q000494:pharmacology*; D009638:Norepinephrine / Q000494:pharmacology*; D010101:Oxygen Consumption / Q000187:drug effects*; D010418:Pentagastrin / Q000494:pharmacology*; D010437:Peptic Ulcer / Q000209:etiology / Q000503:physiopathology*; D011183:Postoperative Complications / Q000503:physiopathology; D014628:Vagotomy
D005663:Furans; D009257:Nafronyl; D010418:Pentagastrin; D009638:Norepinephrine