Therapeutic effects of HS-3, HS-6, benactyzine, and atropine in soman poisoning of dogs.
Investigations into the therapeutic properties of various combinations of the bispyridinium salts HS-3 and HS-6 and the cholinolytics atropine and benactyzine against soman poisoning in unanesthetized male beagles were performed. In our investigations we observed that: 1. The most effective protection against soman poisoning was attained if both oximes were applied early i.m. 6 min after intoxication together with the cholinolytics. 2. On the basis of clinical symptoms HS-6 proved to have a more intensive therapeutic effect than HS-3 upon early application. 3. If HS-3 was applied early after s.c. intoxication with low concentrations of soman (up to 3 LD50), a significant protection or reactivation effect on serium cholinesterase was measured. 4. When HS-3 was applied at the beginning of convulsions--generally 28 min after s.c. intoxication--it also raised the rate of surviving animals. 5. The maximal blood levels for HS-3 and HS-6 were measured 20-30 min after i.m. injection; the half-life values of HS-3 and HS-6 in plasma were 45-60 min.
D000818:Animals; D000931:Antidotes / Q000008:administration & dosage; D001219:Aspartate Aminotransferases / Q000097:blood; D001285:Atropine / Q000627:therapeutic use*; D001535:Benactyzine / Q000627:therapeutic use*; D003402:Creatine Kinase / Q000097:blood; D004285:Dogs; D004334:Drug Administration Schedule; D004359:Drug Therapy, Combination; D007700:Kinetics; D008297:Male; D062025:Organophosphate Poisoning; D011041:Poisoning / Q000201:enzymology; D011220:Pralidoxime Compounds / Q000008:administration & dosage* / Q000097:blood / Q000627:therapeutic use; D012999:Soman / Q000506:poisoning*
D000931:Antidotes; D011220:Pralidoxime Compounds; C003027:HS 6; C012616:HS 3; D001535:Benactyzine; D001285:Atropine; D012999:Soman; D001219:Aspartate Aminotransferases; D003402:Creatine Kinase