Restoration of self-stimulation inhibited by neuroleptics.
Pimozide-induced inhibition of lever-pressing for brain stimulation in the lateral hypothalamic area was differentially restored by the centrally acting anticholinergic, dexetimide and by different dopaminergic drugs. In addition, a differential antagonism towards chlorpromazine-induced inhibition of self-stimulation was shown. The results indicate that anticholinergis (non-competitive antagonism) or drugs which enhance endogenous neuro-transmission by increased release or by uptake blockade (competitive antagonism) are able to reserve the neuroleptic-induced inhibition of self-stimulation more effectively than are receptor agonists.
D000661:Amphetamine / Q000494:pharmacology; D000818:Animals; D001058:Apomorphine / Q000494:pharmacology; D002746:Chlorpromazine / Q000494:pharmacology; D003042:Cocaine / Q000494:pharmacology; D003909:Dexetimide; D018492:Dopamine Antagonists; D007546:Isoquinolines / Q000494:pharmacology; D008297:Male; D010868:Pimozide / Q000037:antagonists & inhibitors*; D051381:Rats; D011954:Receptors, Dopamine / Q000187:drug effects*; D012653:Self Stimulation / Q000187:drug effects*; D014149:Tranquilizing Agents / Q000494:pharmacology*
D018492:Dopamine Antagonists; D007546:Isoquinolines; D011954:Receptors, Dopamine; D014149:Tranquilizing Agents; D010868:Pimozide; D003909:Dexetimide; D000661:Amphetamine; D003042:Cocaine; D001058:Apomorphine; D002746:Chlorpromazine