[Effect of neonatal androgenization on biogenic monoamines of the hypothalamus and the functional activity of the rat pituitary].
Injection of testosterone-propionate to female Wistar rats on the 2nd--4th days of birth failed to alter the serotonin level, but produced a sharp fall of the noradrenaline and dopamine levels in the hypothalamus of 3 1/2-month-old animals. This was accompanied by an increase in the prolactin content in the adenohypophysis with the retention of the normal somatotropic activity. The results of these studied indicated the participation of catecholamines in the pathogenesis of the anovular sterility, and elucidated current views on the control of the hypophysial gonadotropic function.
D000818:Animals; D000831:Animals, Newborn; D001679:Biogenic Amines / Q000378:metabolism*; D005260:Female; D013006:Growth Hormone / Q000378:metabolism; D007031:Hypothalamus / Q000187:drug effects* / Q000378:metabolism; D007986:Luteinizing Hormone / Q000378:metabolism; D010902:Pituitary Gland / Q000187:drug effects*; D010903:Pituitary Gland, Anterior / Q000187:drug effects* / Q000378:metabolism; D051381:Rats; D013739:Testosterone / Q000494:pharmacology*
D001679:Biogenic Amines; D013739:Testosterone; D007986:Luteinizing Hormone; D013006:Growth Hormone
Vliianie neonatal'noĭ androgenizatsii na biogennys monoaminy gipotalamusa i funktsional'nuiu aktivnost' gipofiza krys