Potential CNS antitumor agents--phenothiazines I: Nitrogen mustard derivatives.
Four phenothiazine derivatives containing the bis(beta-chloroethyl)aminopropyl side chain were prepared and evaluated in the murine L-1210, P-388, and B-16 melanoma intraperitoneal tumor systems. Moderate P-388 activity was observed. An aminoethyl phenothiazine mustard was compared with the aminopropyl analogs and was superior in all test systems. None of the compounds tested against the murine ependymoblastoma brain tumor system was active.
D000818:Animals; D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000627:therapeutic use; D001932:Brain Neoplasms / Q000188:drug therapy; D002460:Cell Line; D004806:Ependymoma / Q000188:drug therapy; D066298:In Vitro Techniques; D007942:Leukemia, Experimental / Q000188:drug therapy; D008545:Melanoma / Q000188:drug therapy; D051379:Mice; D009374:Neoplasms, Experimental / Q000188:drug therapy; D009588:Nitrogen Mustard Compounds / Q000138:chemical synthesis* / Q000627:therapeutic use; D010640:Phenothiazines / Q000138:chemical synthesis* / Q000627:therapeutic use; D011619:Psychotropic Drugs / Q000138:chemical synthesis* / Q000627:therapeutic use; D013329:Structure-Activity Relationship
D000970:Antineoplastic Agents; D009588:Nitrogen Mustard Compounds; D010640:Phenothiazines; D011619:Psychotropic Drugs