Analysis of isomeric impurities in a synthesis of the novel anti-inflammatory drug, benoxaprofen.
Gas-liquid chromatographic procedures are described for the determination of isomeric impurities in rho-chlorobenzoyl chloride and the intermediates, 2-(rho-nitrophenyl)-proprionitrile and 2-phenylpropionitrile, in a ten-stage synthesis of benoxaprofen, 2-(rho-chlorophenyl)-alpha-methyl-5-benzoxazoleacetic acid.
D000893:Anti-Inflammatory Agents / Q000138:chemical synthesis*; D001583:Benzoxazoles / Q000032:analysis / Q000138:chemical synthesis*; D002722:Chlorobenzenes / Q000032:analysis*; D002849:Chromatography, Gas; D002853:Chromatography, Liquid; D007536:Isomerism; D008722:Methods; D009570:Nitriles; D011422:Propionates
D000893:Anti-Inflammatory Agents; D001583:Benzoxazoles; D002722:Chlorobenzenes; D009570:Nitriles; D011422:Propionates; C011677:benoxaprofen