Induction of haemoglobin synthesis in Friend leukaemia cells without the necessity of mitosis.
Friend leukaemia cells (745A) were cultured in a soft agar containing 2% dimethylsulfoxide. In situ observation of the marked individual cells verified that the majority of haemoglobin-synthesized cells had not divided during cultivation. This is a direct proof that mitosis is unnecessary for the induction of erythroid differentiation of Friend leukaemia cells.
D002460:Cell Line; D004121:Dimethyl Sulfoxide; D004920:Erythropoiesis; D006454:Hemoglobins / Q000096:biosynthesis*; D008938:Mitosis
D006454:Hemoglobins; D004121:Dimethyl Sulfoxide