Effect of compression force and corn starch on tablet disintegration time.
An unusual occurrence of decreasing tablet disintegration time with increasing tablet hardness was explored. Tablets were made with varying ratios of starch disintegrant to starch paste and compressed with eight different forces. This unusual disintegration pattern is modified by changes in the starch ratios. The reason for this phenomenon is ascribed to gain swelling as the mechanism by which starch acts as a disintegrant.
D002626:Chemistry, Pharmaceutical; D006244:Hardness; D011312:Pressure; D013213:Starch / Q000494:pharmacology*; D013607:Tablets; D013997:Time Factors
D013607:Tablets; D013213:Starch