[Experiments on the medicamental treatment of the noise-induced cochlear damage. Part I. The effect of dipyridamol and allopurinol on the RMP of the cochlea (guinea pig) after noise (author's transl)].
Dipyridamol has in addition to a coronardilatating effect an ati-thrombotic one too. Moreover it facilitates the release of O2 from haemoglobin by increase of the concentration of 2,3-diphosphoglycerate in the erythrocytes. Allopurinol causes a potential resynthesis of ATP in the cells by inhibition of the metabolism of uric acid. Both substances therefore seemed to be suitable for a medicamental therapy of the noise-induced cochlear damage. The expected favourable effect of Dipyridamol and Allopurinol on the organ of Corti after sound exposure (RMP-measurement before and after exposure to pure tone 120 dB SPL) however had not been confirmed by experiment on animals (guinea pig).
D000493:Allopurinol / Q000494:pharmacology / Q000627:therapeutic use*; D003051:Cochlea / Q000187:drug effects; D004163:Diphosphoglyceric Acids / Q000378:metabolism; D004176:Dipyridamole / Q000494:pharmacology / Q000627:therapeutic use*; D004912:Erythrocytes / Q000378:metabolism; D006317:Hearing Loss, Noise-Induced / Q000188:drug therapy*; D006801:Humans
D004163:Diphosphoglyceric Acids; D000493:Allopurinol; D004176:Dipyridamole
Versuche zur medikamentösen Beeinflussung der Lärmschwerhörigkeit. I. Die Wirkung von Dipyridamol und Allopurinol auf das Verhalten der Mikrofonpotentiale der Meerschweinchenkochlea bei Schallbelastung