Development of adenocarcinoma of the prostate in ICR mice locally irradiated with X-rays.
The pelvic region of male ICR/JCL mice 5 approximately 7 weeks of age was irradiated with 1,000 rad of X-rays for a total of 8 exposures ot determine whether such irradiation would induce prostatic carcinoma. Prostatic adenocarcinoma was observed in 5 of 135 animals which survived more than 12 weeks after the first X-irradiation. Because spontaneous development of prostatic adenocarcinoma has not been reported in mice, development of this carcinoma in these animals can be considered to be attributable to X-irradiation.
D000230:Adenocarcinoma / Q000209:etiology* / Q000473:pathology; D000818:Animals; D006965:Hyperplasia / Q000209:etiology; D008297:Male; D051379:Mice; D009374:Neoplasms, Experimental / Q000209:etiology / Q000473:pathology; D009381:Neoplasms, Radiation-Induced / Q000473:pathology; D011471:Prostatic Neoplasms / Q000209:etiology* / Q000473:pathology