The effect of oxytocics on the human cervix during midtrimester pregnancy.
Observations of the effects of oxytocics on the human pregnant cervix have been made in vivo using a double open ended catheter technique. Prostaglandin E, prostaglandin F2alpha and oxytocin had similar but no specific effects upon the intracervical canal pressure; ergometrine caused contractions of the cervix. The significance of these findings is discussed in relation to cervical rupture and cervico-vaginal fistulae that have been reported following second trimester abortion induced with prostaglandins.
D000028:Abortion, Induced / Q000009:adverse effects; D000293:Adolescent; D000328:Adult; D002584:Cervix Uteri / Q000187:drug effects*; D004874:Ergonovine / Q000494:pharmacology; D005260:Female; D006801:Humans; D010120:Oxytocics / Q000494:pharmacology*; D010121:Oxytocin / Q000494:pharmacology; D011247:Pregnancy; D011262:Pregnancy Trimester, Second; D011458:Prostaglandins E / Q000494:pharmacology; D011460:Prostaglandins F / Q000494:pharmacology; D002577:Uterine Cervical Diseases / Q000209:etiology; D014590:Uterine Contraction / Q000187:drug effects; D014597:Uterine Rupture / Q000209:etiology; D014624:Vaginal Fistula / Q000209:etiology
D010120:Oxytocics; D011458:Prostaglandins E; D011460:Prostaglandins F; D010121:Oxytocin; D004874:Ergonovine