[Results of radioimmunologic determination of renin activity and the concentration of angiotensin II in the plasma of hypertensive patients].
Studies of plasma renin activity performed by way of radioimmunoassay in 44 patients with essential hypertension permitted to subdivide the patients with Stage 2 disease into 2 groups: Group 1 with normal or elevated plasma renin activity, and Group 2 -- with sub-normal activity. A statistically significant reverse relationship was found between the age of the hypertensive patients and their plasma renin activity; this parameter tends to decrease along with the increasing duration of the disease. With paralled determinations of renin activity by way of radioimmunoassay and biological method in 20 patients a positive correlation was established; the figures obtained by radioimmunoassay were twice as high as those obtained by the biological technique. A radioimmunological determination of the concentration of angiotensin II in 14 patients with essential hypertension and in 4 normals permitted to reveal its elevation over the level of the normals in 10 of the patients. Positive correlation was established between the renin activity and the angiotensin II concentration.
D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000804:Angiotensin II / Q000097:blood*; D005260:Female; D006801:Humans; D006973:Hypertension / Q000097:blood*; D008297:Male; D008875:Middle Aged; D011674:Pulse; D011863:Radioimmunoassay; D012083:Renin / Q000097:blood*; D013997:Time Factors
D000804:Angiotensin II; D012083:Renin
Rezul'taty radioimmunologicheskogo opredeleniia aktivnosti renina i kontsentratsii angiotenzin II v plazme krovi bol'nykh gipertonicheskoĭ bolezn'iu