[Amantadine: aggressive effect; effect on apomorphine-induced aggressivity in the rat].
In rats characterized by aggressive behaviour induced by apomorphine, only amantadine in doses of 10 mg/kg i.v. and 50 mg/kg i.p. induces a very slight aggressive effect, but in doses of 30 and 50 mg/kg i.p. it inhibits the aggressive behaviour induced by 1 mg/kg apomorphine. The effect is dose-related and it is more pronounced when amantadine (50 mg/kg i.p.) is injected 30 min rather than 1 h before apomorphine.
D000374:Aggression / Q000187:drug effects*; D000547:Amantadine / Q000494:pharmacology*; D000818:Animals; D001058:Apomorphine / Q000037:antagonists & inhibitors*; D004305:Dose-Response Relationship, Drug; D006801:Humans; D051381:Rats
D000547:Amantadine; D001058:Apomorphine
Amantadine: effet agressogène propre; effet sur l'agressivité induite par l'apomorphine chez le rat