Blood fibrinolytic activity and fibrinoid necrosis of small arteries in the rats treated with renal cortical extract.
In order to determine the role of fibrinolytic system in the production of fibrinoid necrosis, blood fibrinolytic activities were measured in the rats nephrectomized and administered with the subcellular fractions (lysosomal or microsomal fraction) of the rat kidney cortical extract. Tissue plasminogen activator was present in both fractions and blood fibrinolytic activity was increased in the rats so treated. But fibrinoid necrosis in pancreatic and mesenteric small arteries was observed only in those administered lysosomal fraction. Direct relationship between the increase of blood fibrinolytic activity and the aggravation of the vascular degeneration could not be observed in this experiment.
D000818:Animals; D001157:Arterial Occlusive Diseases / Q000139:chemically induced*; D005260:Female; D005342:Fibrinolysis / Q000187:drug effects; D007672:Kidney Cortex; D008247:Lysosomes / Q000378:metabolism; D008861:Microsomes / Q000378:metabolism; D009336:Necrosis; D010960:Plasminogen Activators / Q000378:metabolism; D051381:Rats; D012083:Renin / Q000378:metabolism; D014020:Tissue Extracts / Q000009:adverse effects*; D014652:Vascular Diseases / Q000139:chemically induced
D014020:Tissue Extracts; D010960:Plasminogen Activators; D012083:Renin