The importance of amino and ester functions for the curarizing activity of quaternary ammonium salts.
The curarizing and the depolarizing activities of derivatives of suxamethonium and decamethonium have been studied. A receptor model for suxamethonium and for decamethonium is proposed.
D000818:Animals; D002645:Chickens; D003650:Decamethonium Compounds / Q000494:pharmacology; D003964:Diaphragm / Q000187:drug effects; D066298:In Vitro Techniques; D009466:Neuromuscular Blocking Agents; D000644:Quaternary Ammonium Compounds / Q000494:pharmacology*; D051381:Rats; D013329:Structure-Activity Relationship; D013390:Succinylcholine / Q000494:pharmacology
D003650:Decamethonium Compounds; D009466:Neuromuscular Blocking Agents; D000644:Quaternary Ammonium Compounds; D013390:Succinylcholine