Action of the antipsychotic drugs thiotixene and thioridazine on isolated mitochondria.
Thiotixene and thioridazine antipsychotic drugs produce a stimulation of mitochondrial respiration in state 3 and state 4 resulting in a complete respiratory control loss, only accompanied by slight alterations of oxidative phosphorylation. This effect may be of biological significance in the action mechanism of the drugs.
D000818:Animals; D008930:Mitochondria, Liver / Q000187:drug effects* / Q000502:physiology; D010085:Oxidative Phosphorylation; D051381:Rats; D013268:Stimulation, Chemical; D013881:Thioridazine / Q000494:pharmacology*; D013888:Thiothixene / Q000494:pharmacology*
D013888:Thiothixene; D013881:Thioridazine