6-Aminochrysene kinetics in isolated perfused liver.
1. New quantitative assays of 6-aminochrysene by spectrophotometric and g.l.c. methods and t.l.c. separation systems are described. 2. The decline in blood levels of the antitumoral agent 6-aminochrysene was due to its distribution rather than to metabolism to polar metabolites, during liver perfusion experiments. 3. No marked changes in kinetics of 6-aminochrysene were observed during perfusion of livers isolated both from normal and from Walker 256 carcinosarcoma-bearing rats.
D000818:Animals; D001646:Bile / Q000378:metabolism; D002279:Carcinoma 256, Walker / Q000378:metabolism; D007700:Kinetics; D008099:Liver / Q000378:metabolism*; D008297:Male; D010616:Phenanthrenes / Q000097:blood / Q000378:metabolism*; D051381:Rats; D013053:Spectrophotometry
D010616:Phenanthrenes