title: A nationwide outbreak of Reye's Syndrome. Its epidemiologic relationship of influenza B.
abstract: Between December 15 and June 30, 1974, 379 cases of confirmed Reye's syndrome were reported to the Center for Disease Control. Of these, 316 occurred during February and March 1974. A simultaneous surveillance system for influenza B indicated that this clustering of cases of Reye's syndrome correlated both temporally and geographically with influenza B outbreaks. The incidence of Reye's syndrome was higher in rural than in urban centers. Epidemiologically, two groups of cases of Reye's syndrome emerge: those which occur in older children (median age 11 years), cluster in time and geographic region, and are associated with antecedent influenza B infection; and those which occur sporadically thoughout the year, are isolated in occurrence, occur in younger children (median age 6 years), and are associated with a wide variety of antecedent viral illnesses.
mesh_terms: D000293:Adolescent; D000328:Adult; D000367:Age Factors; D002644:Chickenpox / Q000150:complications; D002648:Child; D002675:Child, Preschool; D004196:Disease Outbreaks; D005260:Female; D005767:Gastrointestinal Diseases / Q000150:complications; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007251:Influenza, Human / Q000150:complications / Q000453:epidemiology*; D008297:Male; D009975:Orthomyxoviridae / Q000302:isolation & purification; D012141:Respiratory Tract Infections / Q000150:complications; D012202:Reye Syndrome / Q000453:epidemiology* / Q000209:etiology / Q000382:microbiology; D012424:Rural Population; D013997:Time Factors; D014481:United States; D014611:Vaccination