Diamond-Blackfan syndrome: lymphocyte-mediated suppression of erythropoiesis.
Peripheral blood lymphocytes from six patients with congenital hypoplastic anemia suppressed erythroid cell formation by normal human bone marrow cells in response to erythropoietin in vitro. The results suggest that the anemia in these children has an immunologic basis.
D000305:Adrenal Cortex Hormones / Q000494:pharmacology; D000741:Anemia, Aplastic / Q000097:blood / Q000276:immunology*; D000818:Animals; D001854:Bone Marrow Cells; D002454:Cell Differentiation / Q000187:drug effects; D006224:Cricetinae; D004913:Erythrocytes, Abnormal; D004920:Erythropoiesis / Q000187:drug effects; D004921:Erythropoietin; D008214:Lymphocytes / Q000276:immunology*
D000305:Adrenal Cortex Hormones; D004921:Erythropoietin