The effect of acidosis in hypokalemic periodic paralysis.
Metabolic acidosis was produced in two patients with hypokalemic periodic paralysis by the administration of ammonium chloride over a period of three days. The challenging test of glucose and insulin produced a substantially smaller reduction of both serum potassium concentration and muscle strength than when the patients were tested in normal acid-base balance. The findings agree with earlier work on acetazolamide, suggesting that metabolic acidosis provides protection against episodes of muscle weakness in periodic paralysis.
D000086:Acetazolamide / Q000494:pharmacology / Q000627:therapeutic use; D000138:Acidosis / Q000378:metabolism*; D000328:Adult; D000643:Ammonium Chloride / Q000627:therapeutic use*; D006801:Humans; D007008:Hypokalemia / Q000188:drug therapy* / Q000378:metabolism; D008297:Male; D009132:Muscles / Q000503:physiopathology; D010245:Paralyses, Familial Periodic / Q000188:drug therapy* / Q000378:metabolism; D011188:Potassium / Q000097:blood
D000643:Ammonium Chloride; D000086:Acetazolamide; D011188:Potassium