Synthesis of substituted anilino-3-methoxy-4-substituted acetoxy) benzylidenes and their monoamine oxidase inhibitory and anticonvulsant properties.
Several substituted anilino-(3-methoxy-4-substituted acetoxy) benzylidenes were synthesized and characterized by their sharp melting points and elemental analyses. All substituted benzylidenes competitively inhibited the in vitro monoamine oxidase activity of rat brain homogenates and possessed anticonvulsant activity against pentylenetetrazol-induced convulsions in mice.
D000818:Animals; D000927:Anticonvulsants / Q000138:chemical synthesis*; D001597:Benzylidene Compounds / Q000138:chemical synthesis* / Q000494:pharmacology; D001921:Brain / Q000201:enzymology; D005260:Female; D066298:In Vitro Techniques; D008297:Male; D051379:Mice; D008995:Monoamine Oxidase / Q000378:metabolism; D008996:Monoamine Oxidase Inhibitors / Q000138:chemical synthesis*; D010433:Pentylenetetrazole / Q000037:antagonists & inhibitors; D051381:Rats; D012640:Seizures / Q000517:prevention & control; D013329:Structure-Activity Relationship
D000927:Anticonvulsants; D001597:Benzylidene Compounds; D008996:Monoamine Oxidase Inhibitors; D008995:Monoamine Oxidase; D010433:Pentylenetetrazole