[Introduction to perinatal pharmacology].
Attention has been focused on the specific pharmacokinetics and clinical pharmacology present during the perinatal period following clinical accidents due to high concentrations of oxygen, vitamin K2, sulfonamides, novobiocin, chloramphenicol or drugs of the tetracycline family. The mechanisms of these therapeutic accidents are subject to certain parameters: renal excretion, inactivation systems, binding to plasma albumin, affinity of the tissues for the drugs, intra and extra-vascular compartment distribution, and pharmacogenetics. The special cases of maternal passage of drugs, either during labor or after birth in the milk given to the newborn, are discussed. Lastly, the ethical problem of "therapeutic trials" in newborns are analyzed.
D001942:Breast Feeding; D004992:Ethics, Medical; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D007700:Kinetics; D007743:Labor, Obstetric; D008431:Maternal-Fetal Exchange; D010400:Penicillin G / Q000378:metabolism; D010500:Perinatology; D010600:Pharmacology; D011247:Pregnancy; D011263:Pregnancy Trimester, Third
D010400:Penicillin G
Introduction à la pharmacologie périnatale