In vivo suppression of prostaglandin biosynthesis by non-steroidal anti-inflammatory agents.
In vivo effects of orally administered inhibitors on prostaglandin and F levels were determined in seven organs of the rat. Ibuprofen showed suppression in most tissues three hours after dosing with a return to control values by twenty-four hours. Flurbiprofen and indomethacin showed potent suppression at both three and twenty-four hours after dosing. 3-Acetonitrile, 4,5-bis(p-methoxyphenyl)-2-phenyl-pyrrole showed moderate suppression only in the stomach and duodenum at three hours after dosing with a return to control values by twenty-four hours. Acetaminophen incorporated as a control showed statistically significant suppression only in the liver after twenty-four hours.
D000082:Acetaminophen / Q000494:pharmacology; D000097:Acetonitriles / Q000494:pharmacology; D000284:Administration, Oral; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000008:administration & dosage / Q000494:pharmacology*; D001921:Brain / Q000378:metabolism; D004386:Duodenum / Q000378:metabolism; D005260:Female; D005480:Flurbiprofen / Q000494:pharmacology; D005753:Gastric Mucosa / Q000378:metabolism; D007052:Ibuprofen / Q000494:pharmacology; D007213:Indomethacin / Q000494:pharmacology; D007421:Intestine, Small / Q000378:metabolism; D007668:Kidney / Q000378:metabolism; D008099:Liver / Q000378:metabolism; D008168:Lung / Q000378:metabolism; D011458:Prostaglandins E / Q000096:biosynthesis*; D011460:Prostaglandins F / Q000096:biosynthesis*; D011863:Radioimmunoassay; D051381:Rats; D013997:Time Factors
D000097:Acetonitriles; D000893:Anti-Inflammatory Agents; D011458:Prostaglandins E; D011460:Prostaglandins F; D000082:Acetaminophen; D005480:Flurbiprofen; D007052:Ibuprofen; D007213:Indomethacin