title: Changes in 35S-sulphate uptake in different tissues in the knee and hip regions of rabbits during immobilization, remobilization the development of osteoarthritis.
abstract: In order to observe phenomena accompanying the development of osteoarthritis of the rabbit knee, consistently appearing within 4-6 weeks as a consequence ofimmobilization of this joint, studies on 35S-sulphate (Na2 35SO4) uptake were carried out. The investigation suggests that immobilization of the knee leads within 2-4 weeks to increased sulphate uptake in bone, cartilage and ligaments in the knee region and in the hip (not immobilized) of the same leg. The first marked changes in 35S-sulphate uptake were found in the ligaments and the articular cartilage as early as after 4 days of immobilization.
mesh_terms: D000818:Animals; D002358:Cartilage, Articular / Q000378:metabolism; D005269:Femur / Q000378:metabolism; D005270:Femur Head / Q000378:metabolism; D006621:Hip Joint / Q000378:metabolism*; D007103:Immobilization; D007719:Knee Joint / Q000378:metabolism*; D008023:Ligaments, Articular / Q000378:metabolism; D008592:Menisci, Tibial / Q000378:metabolism; D010003:Osteoarthritis / Q000378:metabolism*; D011817:Rabbits; D013431:Sulfates / Q000378:metabolism*; D013977:Tibia / Q000378:metabolism; D013997:Time Factors
chemical_list: D013431:Sulfates