Disposition of propranolol isomers in mice.
l-Propranolol was found to protect mice from hyperbaric oxygen-induced seizures. The disposition of effective doses of propranolol isomers in mice was followed using stereospecific antibodies with a radioimmunoassay procedure. Serum and tissue concentrations were determined and correlated with the protective effect. Following racemic administration, there were no differences in serum disposition of d- and l-propranolol, although there was initially a preferential uptake of the 1-isomer both into cardiac and brain tissue. The d-isomer exerted synergistic action on the 1-isomer protective effect.
D000818:Animals; D004357:Drug Synergism; D006931:Hyperbaric Oxygenation / Q000009:adverse effects; D008297:Male; D051379:Mice; D011433:Propranolol / Q000378:metabolism* / Q000494:pharmacology; D011863:Radioimmunoassay; D012640:Seizures / Q000517:prevention & control; D013237:Stereoisomerism
D011433:Propranolol