title: Mechanism of action of acetyl kidamycin. II. Inhibition of RNA synthesis in HeLa cells.
abstract: The effects of acetyl kidamycin on RNA synthesis in HeLa cells were investigated. Acetyl kidamycin inhibited the synthesis of 45S pre-rRNA, heterogeneous nuclear RNA (HnRNA) and small molecular weight RNAs, though not to the same degree. The processing of 45S pre-rRNA into 18S and 28S rRNA and that of HnRNA into mRNA were not affected.
mesh_terms: D000903:Antibiotics, Antineoplastic / Q000031:analogs & derivatives / Q000494:pharmacology*; D002467:Cell Nucleus / Q000378:metabolism; D003593:Cytoplasm / Q000378:metabolism; D003864:Depression, Chemical; D006367:HeLa Cells / Q000378:metabolism / Q000648:ultrastructure; D006801:Humans; D011061:Poly A / Q000378:metabolism; D012313:RNA / Q000096:biosynthesis*; D012333:RNA, Messenger / Q000378:metabolism
chemical_list: D000903:Antibiotics, Antineoplastic; D012333:RNA, Messenger; D011061:Poly A; D012313:RNA