[Disruption of erythrocyte membrane permeability for sodium and potassium ions in hypertension].
The kinetics of Na22 efflux from the erythrocytes and K42 accumulation by the erythrocytes in patients with essential hypertension and in normotensive persons was studied. Sodium efflux from the erythrocytes into a normal medium was found to be significantly accelerated in hypertensive patients, and their rate constant of Na/Na exchange in the erythrocytes has a higher value (1.61 +/- 0.39 mol.1(-1) min.-1 versus 0.56 +/- 0.08 - 10(-6) mol. 1(-1).min. -1). The difference is statistically significant only under active transport inhibition with ouabain. K42 accumulation by the erythrocytes is slower than in normotensive indifiduals. The observed changes in the transport of cations are attributed by the authors to an increased passive permeability of the erythrocytic membrane in hypertonics. The latter is interpreted as a fragment of a more general defect of the cell membrane function that may be the cause of activation of the mechanisms that maintain a high arterial pressure.
D000328:Adult; D000368:Aged; D002463:Cell Membrane Permeability; D004912:Erythrocytes / Q000378:metabolism*; D005260:Female; D006801:Humans; D006973:Hypertension / Q000097:blood*; D008297:Male; D008875:Middle Aged; D010042:Ouabain / Q000494:pharmacology; D011188:Potassium / Q000097:blood*; D012964:Sodium / Q000097:blood*
D010042:Ouabain; D012964:Sodium; D011188:Potassium
Dannye o narushenii pronitsaemosti membrany éritrotsitov dlia ionov natriia i kaliia pri gipertonicheskoĭ bolezni