Chemotactic response of leukocytes to cord factor (trehalose-6,6'-dimycolate).
Cord factor (trehalose-6,6'-dimycolate), a glycolipid extractable from myocobacteria, was chemotactic for peritoneal cells of mice at concentrations from 5 to 25 mug/ml medium, as well as for peripheral white blood cells of mice and humans. At higher concentrations, presumably only macrophages were attracted.
D000818:Animals; D001202:Ascitic Fluid / Q000166:cytology; D002633:Chemotaxis; D002634:Chemotaxis, Leukocyte; D003311:Cord Factors / Q000494:pharmacology*; D006017:Glycolipids / Q000494:pharmacology*; D006801:Humans; D007962:Leukocytes / Q000276:immunology; D008264:Macrophages / Q000276:immunology; D051379:Mice; D009000:Monocytes / Q000276:immunology
D003311:Cord Factors; D006017:Glycolipids