[Analysis of flow-volume curves in asthmatic patients and their application in pharmacodynamic tests (author's transl)].
Study of the influence of some parameters upon flow-volume curves and pressure-type body plethysmography during inhalation tests (acetylcholine; metaproterenol) in 10 asthmatic patients (5 males and 5 females). Although the specific conductance decreased when bronchoconstriction was induced and returned to values superior to those measured before provocation when a bronchodilator was administered, changes in specific conductance did not always parallel those of flow-volume curves (V/V), maximum expiratory volume/sec (VEMS) and mid-miximum expiratory flow rate (MMEFR). All the parameters of V/V used here are well correlated with VEMS and MMEFR but not so with the specific conductance. The inverse correlation between the time constants of V/V and residual/total pulmonary capacity (VR/CT) before provocation and the significant decrease after provocation, indicate that V 60 (or 70%) CT and V 75% vital capacity (CV) are most valuable for the evaluation of physiopathological ventilatory changes occurring in bronchoconstriction.
D000109:Acetylcholine / Q000494:pharmacology; D000293:Adolescent; D000328:Adult; D000403:Airway Resistance; D001249:Asthma / Q000175:diagnosis* / Q000503:physiopathology; D001980:Bronchi / Q000187:drug effects*; D005260:Female; D005541:Forced Expiratory Volume; D005652:Functional Residual Capacity; D006801:Humans; D007545:Isoproterenol / Q000494:pharmacology; D008297:Male; D008449:Maximal Expiratory Flow-Volume Curves; D008450:Maximal Midexpiratory Flow Rate; D009921:Metaproterenol / Q000494:pharmacology; D008875:Middle Aged; D010993:Plethysmography, Whole Body; D012129:Respiratory Function Tests; D014109:Total Lung Capacity
D009921:Metaproterenol; D007545:Isoproterenol; D000109:Acetylcholine
Etude analytique des boucles débit/volume chez les asthmatiques et de leur application lors d'épreuves pharmacodynamiques