Deoxypyrimidineuria in the course of chemotherapy in M. Hodgkin.
In patients with Hodgkin's disease the excretion of pyrimidine deoxyribonucleosides in urine was followed up within the course of 92 chemotherapeutical series with cytostatics of COOP group. In 14-day chemotherapy series, the excretion of deoxycytidine, deoxyuridine, thymidine, and their sum was significantly increased. In this paper the results are analyzed and a possibility of utilization of this finding for the judgment in the clinical course of the disease is considered.
D003520:Cyclophosphamide / Q000627:therapeutic use; D003841:Deoxycytidine / Q000652:urine*; D003857:Deoxyuridine / Q000652:urine*; D004359:Drug Therapy, Combination; D005260:Female; D006689:Hodgkin Disease / Q000188:drug therapy / Q000652:urine*; D006801:Humans; D008297:Male; D011241:Prednisone / Q000627:therapeutic use; D011344:Procarbazine / Q000627:therapeutic use; D012737:Sex Factors; D013156:Splenectomy; D013936:Thymidine / Q000652:urine*; D014747:Vinblastine / Q000627:therapeutic use; D014750:Vincristine / Q000627:therapeutic use
D003841:Deoxycytidine; D011344:Procarbazine; D014750:Vincristine; D014747:Vinblastine; D003520:Cyclophosphamide; D011241:Prednisone; D013936:Thymidine; D003857:Deoxyuridine