[Relevance of clinical signs of hypersensitivity in cases of halothane hepatitis].
142 patients with postoperative jaundice following anaesthesia with halothane were divided into two groups:-group A (76 cases) in which halothane appeared to be the sole responsible agent for jaundice, and- group B (66 cases) in which other causes were detected. The incidence of clinical signs considered to be specific for halothane-induced hepatitis (skin rash, arthralgia, bronchospasm, fever of unexplained origin, leukocytosis) was the same in both groups. Only a high eosinophil count was more common in group A. The author found a clear-cut relationship between the frequency of exposure and the onset of hepatitis as well as a shortening of the latent period with increasing numbers of exposures.
D056486:Chemical and Drug Induced Liver Injury / Q000097:blood / Q000209:etiology / Q000473:pathology*; D002940:Circadian Rhythm; D004342:Drug Hypersensitivity / Q000097:blood / Q000209:etiology; D004804:Eosinophils / Q000166:cytology; D006221:Halothane / Q000009:adverse effects*; D006801:Humans; D007565:Jaundice / Q000139:chemically induced / Q000473:pathology
D006221:Halothane
La pertinence dex signes cliniques d'hypersensibilitĕ dans les cas d'hĕpatite à l'halothane