Histoplasmosis in purebred mice: influence of genetic susceptibility and immune depression on treatment.
These experiments demonstrate that susceptibility to Histoplasma infection of the mouse is dramatically influenced by genetic and immunologic factors, and that these factors appear to exert little influence on response to therapy. They further demonstrate that such influence may vary in different visceral organs. The explanation for these observations remains to be elucidated.
D000666:Amphotericin B / Q000627:therapeutic use; D000818:Animals; D000961:Antilymphocyte Serum / Q000009:adverse effects; D005260:Female; D006658:Histoplasma / Q000302:isolation & purification / Q000472:pathogenicity; D006660:Histoplasmosis / Q000188:drug therapy / Q000235:genetics / Q000276:immunology* / Q000401:mortality; D007165:Immunosuppression Therapy; D008099:Liver / Q000382:microbiology; D008168:Lung / Q000382:microbiology; D051379:Mice; D008810:Mice, Inbred C57BL; D008815:Mice, Inbred Strains; D013045:Species Specificity; D013154:Spleen / Q000382:microbiology
D000961:Antilymphocyte Serum; D000666:Amphotericin B