Treatment of uncontrolled hypertension by therapeutic renal infarction.
Certain hemodialysis patients need to be made anephric, either surgically or physiologically. Bilateral renal infarction with shredded absorbable gelatin sponge (Gelfoam) was performed on a woman with malignant hypertension being maintained on chronic center dialysis who was too great a surgical risk for bilateral nephrectomy. Peripheral embolization complicated the procedure resulting in a forefoot amputation for dry gangrene two months later. Her postinfarction peripheral plasma renins remained elevated, and she remained hypertensive but was more easily managed with fewer drugs. This technique has been successfully used by others in 1 patient with chronic renal failure and heavy proteinuria and another with hypertension and a solitary kidney. If, as in our case, postinfarction plasma renins remain elevated and hypertension persists, bilateral nephrectomy could be performed at a later date or infarction could be repeated.
D000328:Adult; D001794:Blood Pressure; D004617:Embolism / Q000209:etiology; D004621:Embolization, Therapeutic; D005260:Female; D005534:Foot Diseases / Q000209:etiology; D005734:Gangrene / Q000209:etiology; D005781:Gelatin Sponge, Absorbable; D006801:Humans; D006973:Hypertension / Q000628:therapy*; D007668:Kidney / Q000098:blood supply*; D011183:Postoperative Complications; D012077:Renal Artery; D006435:Renal Dialysis; D012083:Renin / Q000097:blood
D012083:Renin