Meperidine metabolites: identification of N-hydroxynormeperidine and a hydroxy-methoxy derivative of meperidine in biological fluids.
Gas chromatographic and gas chromatographic-mass spectrometric techniques were used to identify non-acidic metabolites of meperidine (N-methyl-4-phenyl-4-carbethoxypiperidine) excreted in human, rat, and guinea pig urine. Following enzymic hydrolysis N-hydroxynormeperidine was identified in the urine of all three species in addition to the expected metabolites normeperidine and meperidine N-oxide. In rat urine the p-hydroxyphenyl metabolite of meperidine was present in appreciable amounts. Also present in small quantity was a new phenolic metabolite of meperidine containing both hydroxyl and O-methoxyl substituents in the phenyl ring of the parent drug. The latter two metabolites were excreted as conjugates in the rat.
D000328:Adult; D000818:Animals; D002849:Chromatography, Gas; D002855:Chromatography, Thin Layer; D005260:Female; D006168:Guinea Pigs; D006801:Humans; D006900:Hydroxylation; D066298:In Vitro Techniques; D008297:Male; D013058:Mass Spectrometry; D008614:Meperidine / Q000031:analogs & derivatives* / Q000032:analysis / Q000652:urine; D008722:Methods; D051381:Rats
D008614:Meperidine