[Receptor-blockade and receptor-hypersensitivity following neuroleptic treatment (author's transl)].
Neurolepitcs induce a receptor-blocking effect at central dopaminergic neurons. This may be demonstrated in mice by inhibition of methylphenidate induced compulsive gnawing. In the post-receptor-blocking phase the receptor is temporarily hypersensitive to dopaminergic agonists like methylphenidate and apomorphine. By repeated dosage a competition is created between receptor-blockade and hypersensitivity, often in favour of the latter.
D000818:Animals; D001058:Apomorphine / Q000494:pharmacology; D001921:Brain / Q000378:metabolism; D004298:Dopamine / Q000378:metabolism*; D006801:Humans; D008774:Methylphenidate / Q000494:pharmacology; D051379:Mice; D011955:Receptors, Drug / Q000187:drug effects*; D013239:Stereotyped Behavior / Q000187:drug effects; D014149:Tranquilizing Agents / Q000494:pharmacology*
D011955:Receptors, Drug; D014149:Tranquilizing Agents; D008774:Methylphenidate; D001058:Apomorphine; D004298:Dopamine
Rezeptorblockade und Rezeptorhypersensibilität nach Behandlung mit Neuroleptika