[Effect of long-term treatment with synthetic oestrogens on plasma lipids and arterial vessels in male rabbits (author's transl)].
The effects of long-term treatment with synthetic oestrogens (Retalon retard, Sanabo Ltd., Wien, 5 mg/kg i.m. at weekly intervals) were investigated in 12 male rabbits and compared with the data obtained in 9 saline-treated control animals. After 6 months of treatment the oestrogen group showed significantly higher plasma phospholipid (p less than 0.005) and cholesterol (p less than 0.01) concentrations than the control group. However, histological examination of various important arterial vessels (the aorta and the coronary, cerebral, limb and renal arteries) revealed no pathological changes indicative of premature atherosclerosis in either the oestrogen group or in the control group. It is concluded that long-term treatment with synthetic oestrogens does not result in a higher incidence of atherosclerosis in rabbits.
D000818:Animals; D001011:Aorta / Q000187:drug effects; D001158:Arteries / Q000187:drug effects*; D004334:Drug Administration Schedule; D004798:Enzymes / Q000097:blood; D045166:Estradiol Congeners / Q000494:pharmacology*; D008055:Lipids / Q000097:blood*; D008099:Liver / Q000032:analysis; D008297:Male; D011817:Rabbits; D014280:Triglycerides / Q000032:analysis
D004798:Enzymes; D045166:Estradiol Congeners; D008055:Lipids; D014280:Triglycerides
Einfluss einer Langzeitbehandlung mit synthetischen Ostrogenen auf die Plasmalipide und die arteriellen Gefässe männlicher Kaninchen