Urinary levels of vanilmandelic acid and homovanillic acid determined by high-speed liquid chromatography.
High-speed liquid chromatographic determinations of vanilmandelic acid and homovanillic acid in human urine have been made. The effects of taking refreshments on the assay were examined. HVA conjugates in urine also were hydrolyzed and determined. Urinary excretion of vanilmandelic acid, free and conjugated homovanillic acid in normal subjects and patients with neuroblastoma, phaeochromosytoma and Sipple's syndrome were determined and discussed. Urinary excretion values (mean +/- 1 S.D.) of vanilmandelic acid and homovanillic acid in 14 normal subjects were 2.0 +/- 0.7 mg/day and 4.0 +/- 1.0 mg/day, respectively.
D000328:Adult; D002648:Child; D002675:Child, Preschool; D002851:Chromatography, High Pressure Liquid / Q000379:methods; D004032:Diet; D006719:Homovanillic Acid / Q000652:urine*; D006801:Humans; D009447:Neuroblastoma / Q000652:urine; D010282:Parathyroid Neoplasms / Q000652:urine; D010648:Phenylacetates / Q000652:urine*; D010673:Pheochromocytoma / Q000652:urine; D013577:Syndrome; D013964:Thyroid Neoplasms / Q000652:urine; D014642:Vanilmandelic Acid / Q000652:urine*
D010648:Phenylacetates; D014642:Vanilmandelic Acid; D006719:Homovanillic Acid