[On respiratory stimulation by aminophenazol in global insufficiency due to chronic-obstructive diseases of the lungs (author's transl)].
For evaluation of a respiratory analeptic as supplementary therapy in global insufficiency blood gas analyses were performed on 19 patients under normal room air conditions as well as under oxygen breathing. It could be proved that with 2,4-diamino-5-phenylthiazol (aminophenazol; Daptazile) respiratory depression associated associated with chronic obstructive pulmonary diseases can be influenced and that here is statistically significant improvement of respiration. Effects of mechanical breathing and hyperventilatin are discussed -- basing on the present evaluation results they need not be expected. Side effects were not registered. With simultaneous and exhaustive application of all therapeutic means for the remedy of pulmonary obstruction amiphenazol is recommended for use in cases of pulmonary hypoventilation and primary central respiratory depression.
D002245:Carbon Dioxide / Q000097:blood; D006801:Humans; D008173:Lung Diseases, Obstructive / Q000188:drug therapy / Q000503:physiopathology*; D010100:Oxygen / Q000097:blood; D010102:Oxygen Inhalation Therapy; D012119:Respiration / Q000187:drug effects*; D013268:Stimulation, Chemical; D013844:Thiazoles / Q000494:pharmacology* / Q000627:therapeutic use
D013844:Thiazoles; D002245:Carbon Dioxide; D010100:Oxygen
Zur Atemstimulation mit Amiphenazol bei Globalinsuffizienz infolge chronisch obstruktiver Lungenkrankheit