title: Cervical lymph node metastasis as the first manifestation of localized extramedullary plasmacytoma.
abstract: Two patients who had cervical lymph node metastases as the first symptom of a localized soft tissue extramedullary plasmacytoma of the epiglottis and nasopharynx, respectively, are described. Classical multiple myeloma was excluded by bone marrow biopsies and x-ray studies of the skeleton. In both patients, the primary tumor was diagnosed 2 years after excision of the cervical lymph node. One patient had a IgD, lambda myeloma protein in the serum and excreted lambda Bence-Jones protein into the urine. No M-component was found in the other patient. Both are living with a long survival of 8 and 4 years respectively. The presence of a cervical lymph node plasmacytoma should suggest an upper respiratory tract or oropharynx plasmacytoma rather than a primary lymph node plasmacytoma.
mesh_terms: D000368:Aged; D003937:Diagnosis, Differential; D004825:Epiglottis; D005260:Female; D006801:Humans; D007822:Laryngeal Neoplasms / Q000097:blood / Q000473:pathology*; D008207:Lymphatic Metastasis / Q000473:pathology; D008297:Male; D008875:Middle Aged; D009101:Multiple Myeloma / Q000473:pathology; D009194:Myeloma Proteins / Q000097:blood; D009303:Nasopharyngeal Neoplasms / Q000097:blood / Q000473:pathology*; D009333:Neck; D010954:Plasmacytoma / Q000097:blood / Q000473:pathology*
chemical_list: D009194:Myeloma Proteins