title: Adverse skin reaction from vitamin K1.
abstract: Two patients with erythematous, tender, indurated plaques at the site of intramuscular injections of vitamin K1 are described. In one of these, condition was reproduced by the injection of a test dose. In both cases, there was associated liver disease. The red, indurated plaques cleared in 4-14 days. There have been two previous reports in the literature of similar lesions. Altough some of the patients showed sclerodermatous changes at the same site within 2 years of the injections. These unusual reactions have only been seen in patients with liver disease and when a variety of drugs have been administered. It may be that these factors are important in the initiation of the cutaneous response.
mesh_terms: D000328:Adult; D004890:Erythema / Q000139:chemically induced*; D005260:Female; D006801:Humans; D007273:Injections, Intramuscular / Q000009:adverse effects; D008107:Liver Diseases / Q000188:drug therapy; D010837:Vitamin K 1 / Q000009:adverse effects* / Q000627:therapeutic use
chemical_list: D010837:Vitamin K 1