title: IgM and IgG antibody levels to ampicillin in patients with infectious mononucleosis.
abstract: By means of a sensitive radio-immunoassay an antibody-like activity against ampicillin was detected in both IgM and IgG immunoglobulin classes of patients with infectious mononucleosis, being fifteen times the level (for IgM) and six and a half times the level (for IgG) of control subjects. Such ampicillin antibody occurred without obvious relation to prior therapy with ampicillin. This antibody which may originate in a similar manner to Paul-Bunnell antibody was nevertheless immunologically unrelated. The possibility is discussed that the ampicillin rash in infectious mononucleosis results from a disseminated reaction of the small blood vessels to circulating ampicillin-antibody complexes.
mesh_terms: D000667:Ampicillin / Q000009:adverse effects / Q000276:immunology*; D000918:Antibody Specificity; D004342:Drug Hypersensitivity / Q000276:immunology; D006386:Hemagglutination Tests; D006801:Humans; D007074:Immunoglobulin G / Q000032:analysis*; D007075:Immunoglobulin M / Q000032:analysis*; D007244:Infectious Mononucleosis / Q000276:immunology*; D008297:Male
chemical_list: D007074:Immunoglobulin G; D007075:Immunoglobulin M; D000667:Ampicillin