Globin mRNA contains a sequence complementary to double-stranded region of nuclear pre-mRNA.
Melted ds RNA isolated from rabbit bone marrow pre-mRNA was hybridized with excess of globin mRNA which was prepared from rabbit reticulocytes. 7-9% of ds sequences became RNAase-stable and about 30% of the sequences could be bound to poly(U)-Sepharose through poly (A) of mRNA. The size of RNAase-stable hybrid is about 30 nucleotides, that is one fourth of the length of one strand of the ds RNA.
D000818:Animals; D001483:Base Sequence; D001853:Bone Marrow; D005914:Globins; D008970:Molecular Weight; D009691:Nucleic Acid Denaturation; D009693:Nucleic Acid Hybridization; D012333:RNA, Messenger; D011817:Rabbits; D012156:Reticulocytes
D012333:RNA, Messenger; D005914:Globins