Amoxycillin in treatment of typhoid fever in patients with haematological contraindications to chloramphenicol.
Thirty adults with proved typhoid fever were treated with amoxycillin 1 g six-hourly by mouth for an average of 14 days because of haematological contraindications to chloramphenicol. Eighteen patients were Egyptian men with the Mediterranean variety of glucose-6-phosphate dehydrogenase deficiency and an enzyme activity in the red cells fanging from 0 to 3%, and 12 patients had a history of severe but reversible myelosuppression after eight to 12 days' treatment with chloramphenicol 1-5-2 g daily. The clinical and bacteriological responses in this group of patients were compared with those of 30 haematologically normal patients of comparable age and sex treated with chloramphenicol. The results showed that amoxycillin is an effective alternative to chloramphenicol for treating typhoid fever in patients with haematological contraindications to chloramphenicol.
D000293:Adolescent; D000328:Adult; D000658:Amoxicillin / Q000627:therapeutic use*; D000667:Ampicillin / Q000031:analogs & derivatives*; D001663:Bilirubin / Q000097:blood; D001855:Bone Marrow Diseases / Q000139:chemically induced*; D002701:Chloramphenicol / Q000009:adverse effects*; D005955:Glucosephosphate Dehydrogenase Deficiency / Q000150:complications; D006454:Hemoglobins / Q000032:analysis; D006801:Humans; D008297:Male; D014435:Typhoid Fever / Q000150:complications / Q000188:drug therapy*
D006454:Hemoglobins; D002701:Chloramphenicol; D000667:Ampicillin; D000658:Amoxicillin; D001663:Bilirubin