Curvularin from penicillium baradicum Baghdadi NRRL 3754, and biological effects.
Curvularin, a fungal metabolite similar in chemical structure to zearalenone, a potent estrogen, was tested for its estrogenic effects to gilts. No estrogenicity was observed to 60 kg gilts after feeding curvularin per os at a rate of 10 mg per day for 5 days. Curvularin was also nontoxic to mice and chick embryo.
D000818:Animals; D004622:Embryo, Mammalian / Q000187:drug effects; D004968:Estrogens, Non-Steroidal / Q000032:analysis / Q000096:biosynthesis / Q000633:toxicity; D005260:Female; D010407:Penicillium / Q000145:classification / Q000378:metabolism*; D012118:Resorcinols / Q000031:analogs & derivatives / Q000032:analysis / Q000096:biosynthesis / Q000633:toxicity; D013552:Swine; D015025:Zearalenone / Q000031:analogs & derivatives / Q000032:analysis / Q000096:biosynthesis / Q000633:toxicity
D004968:Estrogens, Non-Steroidal; D012118:Resorcinols; D015025:Zearalenone; C013455:curvularin