[Effect of D-, M- and T-antagonists of serotonin on its absorption by human thrombocytes].
Serotonin M-antagonist -- cocaine, and D-antagonist -- dihydroergotamine depressed the serotonin absorption by guman platelets considerably (in a concentration of 10(-4) by 90 and 62%, respectively). Serotonin M-antagonist--morphine, D-antagonist--deseryl, and T-antagonist--typindol inhibited serotonin absorption much less (in a concentration of 10(-4)M by 33, 28 and 18%, respectively). It is supposed that "serotonin" centre of the membrane carrier participating in the process of transmembrane serotonin transport was not identical to any definite type of serotonin receptor.
D000042:Absorption; D001792:Blood Platelets / Q000378:metabolism*; D003042:Cocaine / Q000494:pharmacology; D003864:Depression, Chemical; D004087:Dihydroergotamine / Q000494:pharmacology; D006801:Humans; D007211:Indoles; D008784:Methysergide / Q000494:pharmacology; D009020:Morphine / Q000494:pharmacology; D011985:Receptors, Serotonin; D012701:Serotonin / Q000378:metabolism; D012702:Serotonin Antagonists
D007211:Indoles; D011985:Receptors, Serotonin; D012702:Serotonin Antagonists; D012701:Serotonin; D004087:Dihydroergotamine; D009020:Morphine; D003042:Cocaine; C013716:tipindole; D008784:Methysergide
Vliianie D-, M- i T-antagonistov serotonina na ego pogloshchenie trombotsitami cheloveka