A simple method for blood exchange in mice.
Ease of transfusion and high long-term survival rate were obtained when whole blood was administered via the corpus cavernosum of the penis and removed from the orbital sinus of male C57Bl mice. When 2 volumes of blood are replaced approximately 14% of pre-transfusion red cells remain after hematocrit corrections are made. The post-transfusion hematocrit levels dropped 19%, probably the result of leakage, which is difficult to avoid.
D000818:Animals; D005078:Exchange Transfusion, Whole Blood / Q000379:methods* / Q000401:mortality; D006400:Hematocrit; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D009915:Orbit / Q000098:blood supply; D010413:Penis / Q000098:blood supply