Reduction of the hypoxia-induced depression in the intracellular electrical activity of the ventricular muscle fibers of the rabbit fed on food containing Crataegutt.
The rabbits were divided at random into 2 groups: one was fed for 6 weeks on the rabbit food containing 5 mg Crataegutt per 100 Gm food (CR group), and the other was fed for the same period on the commercial rabbit food and used as a control. Intracellular records were made from fibers in the ventricle of isolated rabbit heart. The inhibitory influences of hypoxia on the resting membrane potential and on the amplitude of action potential of the fiber of the CR group are significantly less than those of the control group. However, the inhibitory influence on the time courses of contraction of the papillary muscle was almost the same between these 2 groups.
D000200:Action Potentials / Q000187:drug effects*; D000818:Animals; D027825:Crataegus; D004032:Diet; D005260:Female; D000860:Hypoxia / Q000503:physiopathology*; D008297:Male; D008564:Membrane Potentials / Q000187:drug effects*; D009200:Myocardial Contraction / Q000187:drug effects; D010210:Papillary Muscles / Q000187:drug effects; D010936:Plant Extracts / Q000494:pharmacology*; D010946:Plants, Medicinal; D011817:Rabbits
D010936:Plant Extracts; C007145:crataegus extract