Stoichiometric interaction of a beta-receptor blocking drug with fraction of liver cytochrome P-450 as a possible cause for its dose-dependent availability.
D000526:Alprenolol / Q000378:metabolism*; D000818:Animals; D001665:Binding Sites; D001682:Biological Availability; D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism*; D004305:Dose-Response Relationship, Drug; D004347:Drug Interactions; D008099:Liver / Q000378:metabolism*; D008297:Male; D008862:Microsomes, Liver / Q000378:metabolism; D051381:Rats
D000526:Alprenolol; D003577:Cytochrome P-450 Enzyme System