[1-Adamanty fluoroformate, a useful reagent in peptide chemistry (author's transl)].
1-Adamantyl fluoroformate was prepared from 1-adamantol and fluorophosgene. The cristalline and stable fluoroformate was allowed to react with amino acids to give the corresponding 1-adamantyloxycarbonyl derivatives in consistently high yields. Additonally this new reagent proved to be ideally reactive for acylation of the imidazol function of histidine and histidyl-peptides.
D000215:Acylation; D000218:Adamantane / Q000031:analogs & derivatives / Q000138:chemical synthesis; D000596:Amino Acids; D001952:Bridged-Ring Compounds / Q000031:analogs & derivatives; D055598:Chemical Phenomena; D002621:Chemistry; D005561:Formates / Q000138:chemical synthesis; D008239:Lysine; D009952:Ornithine
D000596:Amino Acids; D001952:Bridged-Ring Compounds; D005561:Formates; C013391:1-adamantyl fluoroformate; D009952:Ornithine; D008239:Lysine; D000218:Adamantane
Fluorameisensäure-1-adamantylester, ein neues Reagenz zur Einführung der 1-Adamantyloxycarbonyl-Schutzgruppe