On the formation and effects of thromboxane A2 in human platelets.
Incubation of arachidonic acid and prostaglandin G2 with a suspension of human platelets led to formation of an unstable (t1/2, 41+/-7 s) compound, thromboxane A2. Thromboxane A2 induced irreversible aggregation of washed platelets and of platelets in platelet-rich plasma and caused release of serotonin and ADP from platelets in platelet-rich plasma.
D000244:Adenosine Diphosphate / Q000378:metabolism; D001095:Arachidonic Acids / Q000378:metabolism* / Q000494:pharmacology; D001792:Blood Platelets / Q000378:metabolism*; D003470:Culture Media; D006801:Humans; D006880:Hydroxy Acids / Q000096:biosynthesis* / Q000494:pharmacology; D010545:Peroxides / Q000378:metabolism; D010974:Platelet Aggregation / Q000187:drug effects*; D011453:Prostaglandins / Q000378:metabolism* / Q000494:pharmacology; D011714:Pyrans / Q000096:biosynthesis* / Q000494:pharmacology; D012701:Serotonin / Q000378:metabolism; D013997:Time Factors
D001095:Arachidonic Acids; D003470:Culture Media; D006880:Hydroxy Acids; D010545:Peroxides; D011453:Prostaglandins; D011714:Pyrans; D012701:Serotonin; D000244:Adenosine Diphosphate