Depressed chemotactic responses in vitro of peritoneal macrophages from tumor-bearing mice.
The in vitro chemotactic responses of peritoneal macrophages from mice bearing transplantable syngeneic 3-methylcholanthrene-induced tumors in their footpads were depressed to about 50% of normal levels. This chemotactic defect to both lymphocyte- and complement-derived stimuli was evident before the appearance of palpable tumor (within 1 week of tumor injection) and persisted until the death of the animal by 6-8 weeks. Chemotactic depression was not observed with macrophages from mice treated with tissue culture medium, fetal calf serum, incomplete Freund's adjuvant, or syngeneic spleen cells.
D000818:Animals; D001202:Ascitic Fluid / Q000166:cytology; D002633:Chemotaxis; D003165:Complement System Proteins; D004731:Endotoxins / Q000494:pharmacology; D007109:Immunity; D008214:Lymphocytes / Q000276:immunology; D008264:Macrophages / Q000276:immunology*; D008297:Male; D008748:Methylcholanthrene; D051379:Mice; D008809:Mice, Inbred C3H; D009374:Neoplasms, Experimental / Q000139:chemically induced / Q000276:immunology*
D004731:Endotoxins; D008748:Methylcholanthrene; D003165:Complement System Proteins