Inhibition of antibiotic activity in vitro by synthetic melanin.
Synthetic melanin (100 to 1,000 mug/ml) markedly inhibited the in vitro activity of aminoglycosides and tetracyclines but did not affect the activity of betalactam antibiotics, erythromycin, or clindamycin.
D000617:Aminoglycosides / Q000037:antagonists & inhibitors; D000900:Anti-Bacterial Agents / Q000037:antagonists & inhibitors*; D008543:Melanins / Q000494:pharmacology*; D013752:Tetracycline / Q000037:antagonists & inhibitors; D014640:Vancomycin / Q000037:antagonists & inhibitors
D000617:Aminoglycosides; D000900:Anti-Bacterial Agents; D008543:Melanins; D014640:Vancomycin; D013752:Tetracycline