title: Intrathecal pharmacotherapy in coma.
abstract: A study was made of intrathecal infusion as a route for administration of drugs for the CNS. We recognize the presence of blood brain and CSF brain barriers. CDP-choline was used as the brain activator, and the effect of the intrathecally infused drug was investigated clinically. Fifteen patients with disturbances of consciousness due to primary cerebral lesions received a total of 39 intrathecal infusions of CDP-choline, and were examined neurologically and electroencephalographically before and after treatment.
mesh_terms: D000328:Adult; D000368:Aged; D001930:Brain Injuries / Q000188:drug therapy; D002794:Choline / Q000031:analogs & derivatives*; D003128:Coma / Q000188:drug therapy*; D003566:Cytidine Diphosphate Choline / Q000008:administration & dosage* / Q000627:therapeutic use; D004569:Electroencephalography; D005260:Female; D006801:Humans; D007278:Injections, Spinal; D008297:Male; D008590:Meningoencephalitis; D008875:Middle Aged; D013345:Subarachnoid Hemorrhage / Q000188:drug therapy; D013997:Time Factors
chemical_list: D003566:Cytidine Diphosphate Choline; D002794:Choline