[Antenatal diagnosis of fetal sex by detection of Y-chromatin containing cells in maternal blood (author's transl)].
The blood of 100 pregnant women was screened to detect Y-chromatin containing cells of the fetus for prenatal sex-determination. Obtaining 15% false predictions the previous rate of wrong diagnoses could not be reduced significantly. Studying the frequency of fetal leukocytes in the maternal circulation, a significant increase during the pregnancy could not be found. In early pregnancy lymphoid cells containing Y-chromatin can be found first in the 7th week and granulocytes in the 10th week. The prenatal fetal sex-determination from 13 pregnant women was done by chromosome studies, too. Their rate of false diagnoses was 0%. Screening the Y-chromatin containing cells of 13 women, who had given birth to a male child within the last 5 years, we were able to establish a survival of fetal lymphocytes in the maternal circulation within 25 months. An increase in fetal cells according to the length of time the cells were cultured, could not be detected.
D005260:Female; D006098:Granulocytes; D006801:Humans; D008213:Lymphocyte Activation; D008214:Lymphocytes; D008297:Male; D011247:Pregnancy; D011296:Prenatal Diagnosis; D012732:Sex Determination Analysis; D013997:Time Factors
Antenatale Diagnose des fetalen Geschlechts durch Nachweis von Y-chromatinhaltigen Zellen im mütterlichen Blut