title: Congenital release thrombocytopathy: pathophysiology and management.
abstract: Congenital release thrombocytopathy must be included in the differential diagnosis of bleeding diatheses in women. A review of the coagulation profiles of 7 patients with congenital release thrombocytopathy suggests that more sophisticated platelet aggregation studies must be performed when routine screening procedures fail to determine the cause of a clinically suspected bleeding disorder. Establishing the diagnosis helps to avoid the use of medications which cause an acquired platelet dysfunction, and contributes to adequate prophylaxis against surgical and obstetric hemorrhage.
mesh_terms: D000244:Adenosine Diphosphate / Q000494:pharmacology; D000328:Adult; D001772:Blood Cell Count; D001777:Blood Coagulation; D001780:Blood Coagulation Tests; D001791:Blood Platelet Disorders / Q000097:blood / Q000151:congenital* / Q000628:therapy; D001792:Blood Platelets; D003094:Collagen / Q000494:pharmacology; D004837:Epinephrine / Q000494:pharmacology; D005260:Female; D006801:Humans; D008875:Middle Aged; D010298:Parity; D010974:Platelet Aggregation / Q000187:drug effects; D010977:Platelet Factor 3; D011247:Pregnancy; D011517:Prothrombin Time; D012189:Retrospective Studies; D013917:Thrombin / Q000032:analysis; D013925:Thromboplastin / Q000032:analysis
chemical_list: D010977:Platelet Factor 3; D000244:Adenosine Diphosphate; D003094:Collagen; D013925:Thromboplastin; D013917:Thrombin; D004837:Epinephrine