The effect of difenoxin on the lower esophageal sphincter pressure in man.
Difenoxin, a new antidiarrheal agent, had no effect on lower esophageal sphincter pressure in man when given at an oral dose of 2 mg. Thus, this drug does not appear to cause or aggravate symptoms of gastro-esophageal reflux and may safely be used in reflux patients.
D000930:Antidiarrheals / Q000494:pharmacology*; D004157:Diphenoxylate / Q000031:analogs & derivatives / Q000494:pharmacology*; D004943:Esophagogastric Junction / Q000187:drug effects*; D005260:Female; D006801:Humans; D007540:Isonipecotic Acids / Q000494:pharmacology*; D008297:Male; D008365:Manometry; D010919:Placebos; D011312:Pressure; D013997:Time Factors
D000930:Antidiarrheals; D007540:Isonipecotic Acids; D010919:Placebos; D004157:Diphenoxylate