Nocardicin A, a new monocyclic beta-lactam antibiotic II. Structure determination of nocardicins A and B.
The structures of nocardicins A and B, novel monocyclic beta-lactam antibiotics produced by a strain of Nocardia, have been established as 1 and 2, respectively, on the basis of spectroscopic and chemical evidence. They are the first examples of monocyclic beta-lactam antibiotics possessing relatively high antimicrobial activity, and are stereochemically and biologically related to penicillins and cephalosporins.
D000900:Anti-Bacterial Agents / Q000032:analysis*; D055598:Chemical Phenomena; D002621:Chemistry; D006865:Hydrogenation; D006868:Hydrolysis; D007536:Isomerism; D008968:Molecular Conformation; D010084:Oxidation-Reduction; D013329:Structure-Activity Relationship; D047090:beta-Lactams / Q000032:analysis*
D000900:Anti-Bacterial Agents; D047090:beta-Lactams