Picrotoxin convulsions and GABA metabolism after injection of anticonvulsants in chicks.
Two clinically effective anticonvulsants, phenobarbitone and diazepam, protected 5-day old chicks against picrotoxin convulsions without reducing brain GABA-transaminase activity or raising brain GABA concentration. Ethanolamine-O-sulphate and amino-oxyacetic acid, in doses which inhibited GABA-transminase by at least 63% and approximately doubled brain GABA concentration, did not significantly affect the ED50 for picrotoxin convulsions. The ED50 for picrotoxin convulsions was significantly raised by di-n-propylacetate (800 mg/kg) which inhibited GABA transaminase activity by 6% and elevated brain GABA concentration by 26%.
D000612:4-Aminobutyrate Transaminase / Q000037:antagonists & inhibitors; D000613:Aminobutyrates / Q000378:metabolism*; D000818:Animals; D000927:Anticonvulsants / Q000494:pharmacology*; D001923:Brain Chemistry / Q000187:drug effects; D002645:Chickens; D003975:Diazepam / Q000494:pharmacology; D010634:Phenobarbital / Q000494:pharmacology; D010852:Picrotoxin / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D005680:gamma-Aminobutyric Acid / Q000378:metabolism*
D000612:4-Aminobutyrate Transaminase; D000613:Aminobutyrates; D000927:Anticonvulsants; D003975:Diazepam; D010634:Phenobarbital; D010852:Picrotoxin; D005680:gamma-Aminobutyric Acid