[Proceedings: Age and sex specificity of organ distribution and metabolism of chlorprothixene and nortriptyline in the rat (author's transl)].
Chlorprothixene and its N-desmethyl derivative are found to be present in the brain, liver, kidneys and lungs of young animals in larger quantities and for a longer period of time than in older animals. The N-demethylation rate is significantly higher in the brain, liver, kidney and lungs of older animals than of young animals. In general, female animals show higher levels in the organs. The "youth dependent" hyper-content exceeds that of the older animals by the factor of appr. 2. For nortriptyline there is an inverse ratio, with more nortriptyline and desmethylnortriptyline in the older animals than in the young ones. The organ content is also higher in the females than in the males. The "age-dependent" hyper-content exceeds that of the younger animals by the factor of appr. 2. These results correspond roughly with the differences in toxicity.
D000375:Aging; D000818:Animals; D002749:Chlorprothixene / Q000378:metabolism*; D005260:Female; D008297:Male; D009661:Nortriptyline / Q000378:metabolism*; D051381:Rats; D012737:Sex Factors
D002749:Chlorprothixene; D009661:Nortriptyline
Alters- und Geschlechtsbhängigkeit der Organverteilung und des Metabolismus von Chlorprothixen und Nortriptylin bei Ratten