title: Heptachlor: uptake, depuration, retention, and metabolism by spot, Leiostomus xanthurus.
abstract: The estuarine fish, spot (Leiostomus xanthurus), was exposed to 0.27, 0.52, 1.01, 1.99, and 3.87 mug/liter technical grade heptachlor (65% heptachlor, 22% trans-chlordane, 2% cis-chlordane, 2% nonachlor, and 9% unidentified compounds) for 24 days in a flowthrough bioassay, followed by 28 days in heptachlor-free seawater. Concentrations of heptachlor, heptachlor epoxide, and trans- and cis-chlordane in edible tissues were monitored at day 3 and weekly thereafter throughout the bioassay and at the end of the postexposure period. All four chemicals were accumulated by spot. Maximum concentrations of heptachlor were observed on day 3; maximum concentrations of the other three compounds were observed on day 17. The average bioconcentration factors for heptachlor and trans-chlordane were 3,600 and 4,600, respectively. Only 10% or less of the maximum concentrations of heptachlor, heptachlor epoxide, and trans-chlordane accumulated during the exposure period remained after 28 days in pesticide-free seawater; an average of 35% of the cis-chlordane remained. Relative total amounts of heptachlor and cis-chlordane changed during the exposure and post-exposure periods. Nearly all of the heptachlor was eliminated or metabolized to its epoxide. Cis-chlordane, which averaged 4-7% of the total residues (chlordanes and heptachlors) in edible tissues during the exposure, increased to 18-23% of the total residues by the end of the postexposure period.
mesh_terms: D000818:Animals; D002706:Chlordan / Q000378:metabolism; D005399:Fishes / Q000378:metabolism*; D006533:Heptachlor / Q000378:metabolism* / Q000633:toxicity; D006534:Heptachlor Epoxide / Q000378:metabolism; D013997:Time Factors
chemical_list: D006534:Heptachlor Epoxide; D002706:Chlordan; D006533:Heptachlor