Effect of unsaturated lipids on the bile flow and biliary excretion of cholesterol and bile salts in rats.
When rats were fed safflower oil or coconut oil for 30 days, or soyalecithin (EPL) or egg phospholipids for 7 days, the rates of bile flow, concentration of cholesterol in the bile as well as unsaturation in the biliary phospholipids were markedly higher in the animals receiving the more unsaturated lipids. It is concluded that feeding of lipids containing polyunsaturated fatty acids effects an increase in the unsaturation of the biliary phospholipids and thereby causes increased excretion of cholesterol through the bile.
D000818:Animals; D001646:Bile / Q000187:drug effects / Q000378:metabolism / Q000502:physiology*; D001647:Bile Acids and Salts / Q000378:metabolism*; D002784:Cholesterol / Q000378:metabolism*; D002788:Cholesterol Esters / Q000378:metabolism; D004041:Dietary Fats; D005231:Fatty Acids, Unsaturated / Q000494:pharmacology*; D008099:Liver / Q000187:drug effects / Q000378:metabolism; D008297:Male; D009821:Oils; D010743:Phospholipids / Q000378:metabolism; D051381:Rats
D001647:Bile Acids and Salts; D002788:Cholesterol Esters; D004041:Dietary Fats; D005231:Fatty Acids, Unsaturated; D009821:Oils; D010743:Phospholipids; D002784:Cholesterol