[A comparative investigation of acetylsalicyclic acid and indirect anticoagulants for the prophylaxis of venous thromboses in patients with an orthopedic-traumatologic case history (author's transl)].
The efficacy of acetylsalicylic acid as a general prophylactic for thromboembolic complications in bedridden adult patients with bone injuries and osteotomies was investigated. The results were compared with a control group and a group of patients receiving indirect anticoagulants. A statistically significant difference in the frequency of thromboembolic complications between the group receiving acetylsalicylic acid and the control group could not be established. The group receiving indirect anticoagulants showed a tenfold decrease in phlebothromboses and a fourteenfold decrease in pulmonary complications when compared with the control group. Even in high doses, acetylsalicylic acid is less reliable than anticoagulation therapy for the prophylaxis of venous thromboses and embolic pulmonary complications.
D001241:Aspirin / Q000008:administration & dosage*; D005260:Female; D050723:Fractures, Bone / Q000150:complications; D006801:Humans; D008297:Male; D008875:Middle Aged; D010027:Osteotomy; D010630:Phenindione / Q000008:administration & dosage*; D011183:Postoperative Complications; D011655:Pulmonary Embolism / Q000517:prevention & control; D013923:Thromboembolism / Q000517:prevention & control; D013924:Thrombophlebitis / Q000517:prevention & control*
D010630:Phenindione; D001241:Aspirin
Eine vergleichende Untersuchung über Acetylsalicylsäure und indirekte Antikoagulantien zur Prophylaxe venöser Thombosen bei einem orthopädisch-traumatologischen Krankengut