Binding of phytohaemagglutinin to serum substances and inhibition of lymphocyte transformation in Hodgkin's disease.
Serum from eleven of fifty-four patients with Hodgkin's disease inhibited phytohaemagglutinin (PHA) stimulation of both autologous and homologous lymphocytes. The inhibitory effect resided in the macromolecular fraction of these sera. PHA was shown to bind to serum substances in inhibitory sera and the degree of PHA binding in the macromolecular fraction correlated directly with the extent of inhibition.
D001769:Blood; D002470:Cell Survival; D005260:Female; D006689:Hodgkin Disease / Q000276:immunology*; D006801:Humans; D037102:Lectins; D008213:Lymphocyte Activation; D008297:Male; D011485:Protein Binding
D037102:Lectins