The uptake of DH-ergotoxine by different parts of the cat brain.
The distribution pattern of 3H-DH-ergotoxine, labelled by a direct hydration with tritium, was investigated in the cat brain. Apart from the pituitary gland, the brain shows an average DH-ergotoxine concentration of 10(-7) M. A 15% greater incorporation of DH-ergotoxine occurs in the cerebellum than in the cerebrum. In gradient centrifugation studies it is seen that 60% of the incorporated DH-ergotoxine is localized in the synaptosomal fraction. This finding seems to verify the microhistautoradiographic results of this investigation. The observation of a DH-ergotoxine binding in selected structures of the CNS , predominantly the synapses, could explain central nervous activities of DH-ergotoxine.
D000818:Animals; D001921:Brain / Q000378:metabolism*; D002415:Cats; D002531:Cerebellum / Q000378:metabolism*; D002540:Cerebral Cortex / Q000378:metabolism; D004873:Ergolines / Q000378:metabolism; D004876:Ergot Alkaloids / Q000378:metabolism*; D008526:Medulla Oblongata / Q000378:metabolism; D011149:Pons / Q000378:metabolism; D012154:Reticular Formation / Q000378:metabolism; D013116:Spinal Cord / Q000378:metabolism; D013569:Synapses / Q000378:metabolism
D004873:Ergolines; D004876:Ergot Alkaloids