Alterations in plasma sialyltransferase associated with successful chemotherapy of a disseminated tumor. Case report.
Levels of plasma sialyltransferase were measured in a  patient with disseminated carcinoma of the testes. Initial enzyme values, elevated six fold above those in normal controls, were among the highest thus far encountered in a population of patients with various stages and types of malignancy. During a remarkable respose to chemotherapy with cis-diaminodichloroplatinum, plasma sialyltransferase levels fell markedly. Serial measurement of this enzyme may aid in evaluation of tumor responsiveness to therapy in patients whose disease is not readily measurable.
D000328:Adult; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D002945:Cisplatin / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D012075:Remission, Spontaneous; D012799:Sialyltransferases / Q000097:blood*; D013724:Teratoma / Q000097:blood / Q000188:drug therapy; D013736:Testicular Neoplasms / Q000097:blood / Q000188:drug therapy*; D014166:Transferases / Q000097:blood*
D000970:Antineoplastic Agents; D014166:Transferases; D012799:Sialyltransferases; D002945:Cisplatin