title: Mast-cell reaction in precancerous mouse skin: an immunological response?
abstract: The promotion phase of carcinogenesis in mouse skin is accompanied by a mast-cell reaction in the upper dermis. Evidence is presented which suggests that this may be an immunological response, whereby distant lymphocytes migrate to the area and, in the presence of young fibroblasts, become transformed into tissue mast cells.
mesh_terms: D000818:Animals; D008214:Lymphocytes; D008407:Mast Cells; D051379:Mice; D011230:Precancerous Conditions / Q000276:immunology*; D012867:Skin / Q000166:cytology*; D012878:Skin Neoplasms / Q000276:immunology*