51Chromium-release microassay technique for cell-mediated immunity to mumps virus: correlation with humoral and delayed-type skin hypersensitivity responses.
Lymphocyte-mediated immune responsiveness to mumps virus was studied with use of a 51chromium (51Cr)-release microassay of lymphocytotoxicity to target cells persistently infected with mumps virus. The release of 51Cr from immune cells was found to be virus-specific and reproducible and correlated well with the presence of antibody but not with the magnitude of antibody levels. Delayed-type skin hypersensitivity and specific immune release of 51Cr did not correlate well, which suggests that the two events may be mediated by different populations of cells.
D000917:Antibody Formation; D000918:Antibody Specificity; D003601:Cytotoxicity Tests, Immunologic; D006385:Hemagglutination Inhibition Tests; D006801:Humans; D006968:Hypersensitivity, Delayed / Q000276:immunology*; D007111:Immunity, Cellular; D008214:Lymphocytes / Q000276:immunology; D009109:Mumps virus / Q000276:immunology*; D012882:Skin Tests; D013997:Time Factors