title: Alternative products in the reaction of 2-nitro-5-thiocyanatobenzoic acid with thiol groups.
abstract: 2-Nitro-5-thiocyanatobenzoic acid has been proposed as a reagent for converting thiol groups in proteins into their S-cyano derivatives. Evidence was obtained for formation of both the S-cyano derivative and the mixed disulphide derivative. Formation of the S-cyano derivative can be promoted by addition of excess of CN-to the reaction mixture.
mesh_terms: D055598:Chemical Phenomena; D002621:Chemistry; D003402:Creatine Kinase; D003486:Cyanides; D004220:Disulfides; D005978:Glutathione; D008623:Mercaptoethanol; D009579:Nitrobenzoates; D011506:Proteins; D013329:Structure-Activity Relationship; D013439:Sulfhydryl Reagents; D013861:Thiocyanates
chemical_list: D003486:Cyanides; D004220:Disulfides; D009579:Nitrobenzoates; D011506:Proteins; D013439:Sulfhydryl Reagents; D013861:Thiocyanates; D008623:Mercaptoethanol; D003402:Creatine Kinase; D005978:Glutathione