Effect of intraventricular administration of isoprenaline on urinary function in the goat.
Intraventricular infusion of small doses of isoprenaline (ISO) in conscious non-hydrated goats produced a significant diuretic response, as well as a decrease in the excretion rate of Na+, K+ and Cl- in the urine; these effects were dose-dependent. An increase in free water clearance was observed as well. Pretreatment with propranolol, injected into the 3rd ventricle, completely abolished the ISO-induced diuretic effects, whereas phentolamine was ineffective. The data suggest that hypothalamic beta-adrenoreceptors are concerned with an inhibition of vasopressin release, inducing a diuretic response.
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D004231:Diuresis / Q000187:drug effects*; D005260:Female; D006041:Goats; D007276:Injections, Intraventricular; D007545:Isoproterenol / Q000008:administration & dosage / Q000494:pharmacology*; D010646:Phentolamine / Q000494:pharmacology; D011433:Propranolol / Q000494:pharmacology; D013997:Time Factors; D014867:Water / Q000494:pharmacology
D014867:Water; D011433:Propranolol; D007545:Isoproterenol; D010646:Phentolamine