Effects of inhibitors of prostaglandin synthesis on rebound excitation of guinea-pig small bowel.
The prostaglandin synthetase inhibitors indomethacin and acetyl salicylic acid did not affect the post-stimulus rebound excitation of guinea-pig duodenal and jejunal circular muscle with transmural electrical stimulation at 1 min intervals. In the absence of any drug, sequential time-dependent changes in amplitude of the rebound contractions were: (1) progressive increase during first 10 min, (2) a plateau at 30 min, (3) progressive decline to almost no response over 3 h. The results indicate that, in the circular muscle layer, prostaglandin synthesis is not required for production of the rebound response following electrical stimulation of inhibitory neurons.
D000818:Animals; D001241:Aspirin / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D004386:Duodenum / Q000187:drug effects; D004558:Electric Stimulation; D005260:Female; D005769:Gastrointestinal Motility / Q000187:drug effects*; D006168:Guinea Pigs; D066298:In Vitro Techniques; D007213:Indomethacin / Q000494:pharmacology*; D007583:Jejunum / Q000187:drug effects; D008297:Male; D009119:Muscle Contraction / Q000187:drug effects; D009474:Neurons; D011453:Prostaglandins / Q000096:biosynthesis*
D011453:Prostaglandins; D001241:Aspirin; D007213:Indomethacin