title: Aspects of lipid and carbohydrate metabolism, dietary biotin and fatty liver and kidney syndrome in broilers.
abstract: Two experiments were performed to investigate the biochemical changes associated with FLKS. A diet reported to induce FLKS was fed with or without supplementary biotin to broilers. In experiment 1 various stresses were applied to the birds. 2. In experiment 1 mortality from FLKS was 6% and in experiment 2 nil. Stress had little effect on the induction of the syndrome. 3. There were no significant differences due to diet in any of the variables examined in apparently normal birds. 4. Birds affected by FLKS showed the typical changes of increased liver and kidney weights and lipid contents but hepatic enzyme activities did not differ significantly from those of normal birds except that malate dehydrogenase (decarboxylating) (NADP) activity was significantly decreased. 5. Despite the low content of biotin in the unsupplemented diet (57 mug/kg) liver biotin content was not low in birds fed on this diet. 6. The results suggest that the incidence of FLKS is not related solely to dietary biotin content.
mesh_terms: D001275:ATP Citrate (pro-S)-Lyase / Q000378:metabolism; D000818:Animals; D001710:Biotin / Q000378:metabolism*; D050260:Carbohydrate Metabolism; D002645:Chickens; D005234:Fatty Liver / Q000378:metabolism / Q000662:veterinary*; D005260:Female; D007668:Kidney / Q000378:metabolism; D007674:Kidney Diseases / Q000378:metabolism / Q000662:veterinary*; D050356:Lipid Metabolism; D008099:Liver / Q000378:metabolism; D008291:Malate Dehydrogenase / Q000378:metabolism; D011201:Poultry Diseases / Q000378:metabolism*; D013577:Syndrome / Q000662:veterinary
chemical_list: D001710:Biotin; D008291:Malate Dehydrogenase; D001275:ATP Citrate (pro-S)-Lyase