Experimental canine distemper infection as a means of demonstrating latent effects of subacute lead intoxication.
Observations on the response of the body to experimental infection with distemper virus in dogs previously dosed subacutely with lead have demonstrated a latent effect of lead on several body systems. Effects which indicated a relationship to earlier treatment with lead included evidence for stimulation of haemoglobin synthesis, changes to red blood cells resulting in increased destruction, increased vulnerability of the parenchymatous cells of the liver to damage, reduction in the weight of the skeleton and thyroid, an increase in weight of the thymus and brain and histopathological changes in the thymus.
D000818:Animals; D001772:Blood Cell Count; D001842:Bone and Bones / Q000503:physiopathology*; D001921:Brain / Q000503:physiopathology; D004195:Disease Models, Animal; D004216:Distemper / Q000503:physiopathology*; D004285:Dogs; D005260:Female; D006321:Heart / Q000503:physiopathology; D006400:Hematocrit; D006452:Hemoglobinometry; D007855:Lead Poisoning / Q000503:physiopathology*; D008297:Male; D009929:Organ Size; D013950:Thymus Gland / Q000503:physiopathology