title: Familial occurrence of gonadal tumors in XY females with breast development.
abstract: Three sisters with XY gonadal dysgenesis are presented. All of them have primary amenorrhea and breast development, and in two, a gonadal tumor, seminoma (dysgerminoma) was found. The danger of gonadal neoplasm in XY females with normal female build is emphasized.
mesh_terms: D000293:Adolescent; D000328:Adult; D000568:Amenorrhea / Q000235:genetics; D001940:Breast / Q000254:growth & development; D004407:Dysgerminoma / Q000150:complications* / Q000235:genetics / Q000473:pathology; D005260:Female; D006066:Gonads / Q000473:pathology; D006801:Humans; D010641:Phenotype; D012730:Sex Chromosomes; D014424:Turner Syndrome / Q000150:complications* / Q000235:genetics