Dopaminergic control of adenohypophysial weight and serum ceruloplasmin level in rats.
Twice a week male rats were given injections of 1 mg estradiol benzoate as an aqueous microcrystalline suspension; they were also given 0.1, 0.2 or 0.4 mg Pimozide (a dopamine receptor blocker) daily in their food. Only the maximum Pimozide dose potentiated the effect of estradiol on adenohypophysial weight and on the binding capacity of adenohypophysial proteins for thyroxine in vitro. The estrogen-induced increase in the serum ceruloplasmin level, however, was potentiated significantly by all 3 Pimozide doses.
D000818:Animals; D002570:Ceruloplasmin / Q000378:metabolism*; D004357:Drug Synergism; D004958:Estradiol / Q000031:analogs & derivatives* / Q000494:pharmacology; D008297:Male; D009929:Organ Size / Q000187:drug effects; D010868:Pimozide / Q000494:pharmacology*; D010902:Pituitary Gland / Q000187:drug effects*; D010903:Pituitary Gland, Anterior / Q000187:drug effects* / Q000378:metabolism; D011485:Protein Binding; D051381:Rats; D013974:Thyroxine / Q000378:metabolism
D010868:Pimozide; D004958:Estradiol; D002570:Ceruloplasmin; D013974:Thyroxine