The effect of repeated dose of x-irradiation on the progress of HeLa cells through the cell cycle.
In contradistinction to the increased fraction of HeLa S 3 cells in S phase after irradiation by a single dose in a range of 25--200 R, cultures irradiated by a second dose at time of morphologic restitution of mitotic activity exhibited decreased fraction of cells in S phase. The interpretation is that passage from G1 to S was reduced due to disturbances in subsystems which have not been fully repaired.
D002455:Cell Division / Q000528:radiation effects*; D004273:DNA, Neoplasm / Q000096:biosynthesis; D006367:HeLa Cells
D004273:DNA, Neoplasm