[Binding of phosphoorganic cholinesterase inhibitors in rat brain tissue].
Hydrophobity (coefficient in distribution in the hexane water system) and the content of cholinesterase organophosphorous inhibitors (OPI) of the structure Ro (CH3) P (O) SC2H4 SC2H5 were studied in the rat brain. When the O-alkyl radical is increased hydrophobity rises and the relative content of free OPI in the brain extracted by chloroform decreases. With an increase in R from the ethyl to butyl one the ability to the  additional inhibition of the brain own cholinesterase lowers due to incubation of homogenate at 37 degrees C, that evidences for an essential drop in the studied series of the free OPI fraction relative to the free OPI extracted by chloroform.
D000818:Animals; D001921:Brain / Q000201:enzymology / Q000378:metabolism*; D055598:Chemical Phenomena; D002621:Chemistry; D002800:Cholinesterase Inhibitors / Q000378:metabolism*; D002802:Cholinesterases / Q000378:metabolism; D009946:Organothiophosphorus Compounds / Q000378:metabolism*; D051381:Rats
D002800:Cholinesterase Inhibitors; D009946:Organothiophosphorus Compounds; D002802:Cholinesterases
Osobennosti sviazyvaniia fosfororganicheskikh ingibitorov kholinésterazy v tkani mozga krys