[A modified screening model for potential cancerostatics by i.v. application of L 1210 ascites cells (author's transl)].
Intravenous application of L 1210 ascites cells failed to produce generalized leukemias. The treated animals died after 6-7 days within a short interval time, revealing the picture of massive tumor cell infiltrations in liver and spleen. Using histological and autoradiographical methods it has been established that the primary processes of ascites cell proliferations occur in liver and spleen. The tested reference substances, cytosine arabinoside and cyclophosphamide, showed in this modified model the same effects as after intraperitoneal application. The extremely short death interval of the control animals makes possible a more precise distinction between the death curves of control and test groups.
D000818:Animals; D003520:Cyclophosphamide / Q000627:therapeutic use; D003561:Cytarabine / Q000627:therapeutic use; D004353:Drug Evaluation, Preclinical; D007942:Leukemia, Experimental / Q000188:drug therapy*; D051379:Mice; D008811:Mice, Inbred DBA; D008954:Models, Biological
D003561:Cytarabine; D003520:Cyclophosphamide
Ein modifiziertes Screeningmodell für potentielle Kanzerostatika mittels intravenöser Applikation von L-121--Asziteszellen