[Telomeric chromosome fusion in cells treated with colcemid and 5-bromdeoxyuridine].
Specific chromosomes with two or more centromeres were found in the tetraploid metaphases of the second mitotic division after combined treatment with coldemid (0.05 mug/ml) and 5-bromodeoxyuridine (50 mug/ml) for 24 hours in the aneuploid Chinese hamster cell line. They were formed by telometric fusion of chromosomes and were absent in the cells treated with colcemid or 5-bromodeoxyuridine separately. A possible relation of this phenomenon to the telomeric association of chromosomes in the interphase nucleus, as well as to the chromosomal disturbances in the Louis Bar symdrome (ataxia -- telangiectasia) is discussed.
D001260:Ataxia Telangiectasia / Q000235:genetics; D001973:Bromodeoxyuridine / Q000494:pharmacology*; D002875:Chromosomes / Q000187:drug effects*; D002999:Clone Cells; D003078:Colchicine / Q000494:pharmacology*; D004347:Drug Interactions; D006801:Humans
D001973:Bromodeoxyuridine; D003078:Colchicine
Telomernoe sliianie khromosom v kletkakh, obrabotannykh koltsemidom i 5-bromdezoksiuridinom