Characteristics of unlimited access to self-administered stimulant infusions in dogs.
When drug-naive dogs were given unlimited access to response-contingent intravenous infusions of either d-amphetamine, phenmetrazine, or methylphenidate, a regular cycle of drug intake interspersed with periods of voluntary abstinence was seen. During the drug self-administration phases there was a marked increase in locomotor behavior and stereotypy along with a decrease in body weight; the rest periods were characterized by minimal activity. These results are similar to those observed when humans engage in high-dose intravenous abuse of psychomotor stimulants.
D000818:Animals; D001835:Body Weight / Q000187:drug effects; D003216:Conditioning, Operant; D004195:Disease Models, Animal; D004285:Dogs; D006801:Humans; D007263:Infusions, Parenteral; D008774:Methylphenidate / Q000008:administration & dosage* / Q000494:pharmacology; D009043:Motor Activity / Q000187:drug effects; D010633:Phenmetrazine / Q000008:administration & dosage* / Q000494:pharmacology; D012054:Reinforcement, Psychology; D012651:Self Medication; D013239:Stereotyped Behavior / Q000187:drug effects; D019966:Substance-Related Disorders / Q000150:complications
D008774:Methylphenidate; D010633:Phenmetrazine