Mitochondrial abnormalities in human phaeochromocytoma.
Mitochondrial abnormalities are reported in four cases of phaeochromocytoma. These abnormalities include swelling and scant cristae, intramitochondrial dense bodies, septate-like junctions, intercristal fusion plus spheroidal bodies, and intramitochondrial rodlets. These structural mitochondrial changes are associated with reduction in activity of the mitochondrial enzymes, monoamine oxidase and succinic dehydrogenase.
D000310:Adrenal Gland Neoplasms / Q000201:enzymology / Q000648:ultrastructure*; D000313:Adrenal Medulla; D006801:Humans; D008854:Microscopy, Electron; D008928:Mitochondria / Q000201:enzymology / Q000648:ultrastructure*; D008995:Monoamine Oxidase / Q000032:analysis; D010673:Pheochromocytoma / Q000201:enzymology / Q000648:ultrastructure*; D013385:Succinate Dehydrogenase / Q000032:analysis
D013385:Succinate Dehydrogenase; D008995:Monoamine Oxidase