[Influence of denervation on metabolism of phospholipid in the rat vas deferens].
Influence of denervation on phospholipid metabolism in the vas deferens and effect of phospholipase C treatment on sensitivity of the vas deferens for noradrenaline were studied. The incorporation of 32P-orthophosphate into phosphatidylethanolamine and phosphatidylcholine was markedly increased by denervation. Incorporation of 32P-orthophosphate into proteolipid was accelerated more than that of 3H-leucine. Sensitivity of the denervated vas deferens for noradrenaline was strongly reduced by phospholipase C treatment. These data suggest that the supersensitivity of the denervated vas deferens for noradrenaline was mainly due to the increase in phospholipids.
D000818:Animals; D003714:Denervation; D007930:Leucine / Q000378:metabolism; D008074:Lipoproteins / Q000096:biosynthesis; D008297:Male; D009638:Norepinephrine / Q000494:pharmacology; D010710:Phosphates / Q000378:metabolism; D010713:Phosphatidylcholines / Q000096:biosynthesis; D010714:Phosphatidylethanolamines / Q000096:biosynthesis; D010740:Phospholipases / Q000494:pharmacology; D010743:Phospholipids / Q000378:metabolism*; D051381:Rats; D014649:Vas Deferens / Q000187:drug effects / Q000378:metabolism*
D008074:Lipoproteins; D010710:Phosphates; D010713:Phosphatidylcholines; D010714:Phosphatidylethanolamines; D010743:Phospholipids; D010740:Phospholipases; D007930:Leucine; D009638:Norepinephrine