Adenocarcinoma of the glandular stomach following 3-methylcholanthrene, N-nitrosodiethylamine, or N-nitrosodimethylamine feeding in carcinogen-susceptible inbred Syrian.
Invasive adenocarcinoma of the glandular stomach was induced in 3 BIO 87.20 inbred Syrian hamsters by the administration of 1 ppm N-nitrosodiethylamine or N-nitrosodimethylamine in the drinking water, and in 2 BIO 15.16 and 5 BIO 72.29 inbred Syrian hamsters by gavage of 3-methylcholanthrene. In contrast, many other similarly treated inbred Syrian hamster lines did not develop carcinoma of the glandular stomach. The glandular stomachs of rats and mice are resistant to polycyclic hydrocarcon carcinogenesis; however, the glandular stomachs of certain inbred Syrian hamsters develop adenocarcinoma after polycyclic hydrocarbon gavage. This work demonstrated the importance of genetic factors.
D000230:Adenocarcinoma / Q000139:chemically induced* / Q000473:pathology; D000818:Animals; D006224:Cricetinae; D004052:Diethylnitrosamine; D004128:Dimethylnitrosamine; D005260:Female; D008297:Male; D008647:Mesocricetus; D008748:Methylcholanthrene; D009374:Neoplasms, Experimental / Q000139:chemically induced / Q000473:pathology; D009602:Nitrosamines; D013045:Species Specificity; D013274:Stomach Neoplasms / Q000139:chemically induced* / Q000473:pathology
D009602:Nitrosamines; D004052:Diethylnitrosamine; D008748:Methylcholanthrene; D004128:Dimethylnitrosamine