Carcinogenicity of N'-nitrosonornicotine in Sprague-Dawley rats.
N'-Nitrosonornicotine was added to the drinking water of outbred Sprague-Dawley rats. Adenocarcinomas of the olfactory epithelium occurred in all 15 rats, squamous papillomas o- the esophagus in 1, squamous papillomas of the nonglandular stomach in 1, and a hepatacellular tumor in 1. The possible ingestion and subsequent in vivo nitrosation of nicotine and/or nornicotine could create a serious carcinogenic hazard to cigarette smokers.
D000230:Adenocarcinoma / Q000139:chemically induced; D000818:Animals; D002273:Carcinogens; D005260:Female; D009296:Nasal Cavity; D009374:Neoplasms, Experimental / Q000139:chemically induced*; D009538:Nicotine / Q000031:analogs & derivatives* / Q000633:toxicity; D009602:Nitrosamines / Q000633:toxicity*; D009669:Nose Neoplasms / Q000139:chemically induced; D010212:Papilloma / Q000139:chemically induced; D051381:Rats; D012907:Smoking / Q000150:complications; D013274:Stomach Neoplasms / Q000139:chemically induced
D002273:Carcinogens; D009602:Nitrosamines; D009538:Nicotine; C008655:N'-nitrosonornicotine