[Increase in the frequency of spontaneous chromosome aberrations with age in rats].
675 oocytes from 1294 studied were found suitable for counting chromosomes and caryotyping. 86,8% of oocytes (586) had a normal chromosome number, while aneuploidy was observed in 12,7% of oocytes (86). Among them 72 (10,67%) were with hypoploidy, while only 14 (2,07%) were hyperploid with 22 chromosomes. Structural chromosome aberrations were found in three oocytes: two of them had chromosome fragments and one had a break in the long arm of the chromosome 1.
D000375:Aging; D000818:Animals; D002869:Chromosome Aberrations; D005260:Female; D009865:Oocytes / Q000648:ultrastructure; D051381:Rats
Uvelichenie chastoty spontannykh aberratsiĭ khromosom s vozrastom krys