Colchicine inhibition of the first phase of amyloid synthesis in experimental animals.
Colchicine was found to inhibit the first phase of casein-induced synthesis of murine amyloid. When mice were treated with colchicine during the first 7 days of an amyloid induction regimen or when colchicine was given to the donor mice in a transfer model, the amyloidogenic stimulus of casein was blocked completely. Amyloid synthesis was however, not interrupted by the administration of colchicine during the last 7 days of the casein regimen nor by colchicine treatment of recipient mice in a transfer model.
D000682:Amyloid / Q000096:biosynthesis*; D000686:Amyloidosis / Q000139:chemically induced / Q000517:prevention & control; D000818:Animals; D002364:Caseins / Q000037:antagonists & inhibitors; D003078:Colchicine / Q000494:pharmacology*; D051379:Mice; D013158:Splenic Diseases / Q000517:prevention & control; D013997:Time Factors
D000682:Amyloid; D002364:Caseins; D003078:Colchicine