Persistence of thromboxane A2-like material and platelet release-inducing activity in plasma.
During the incubation of arachidonic acid with platelet-rich plasma, a persistent activity appeared that caused the release of [14C]5-hydroxytryptamine from indomethacin-treated platelets. By the time-course of its appearance and disappearance, this release-inducing activity could be dissociated from prostaglandin endoperoxides and associated with thromboxane A2-like material. This material persists in plasma because of its continued production and increased stability.
D001095:Arachidonic Acids; D001792:Blood Platelets / Q000378:metabolism*; D006207:Half-Life; D006880:Hydroxy Acids / Q000097:blood*; D010545:Peroxides / Q000378:metabolism; D010974:Platelet Aggregation; D011453:Prostaglandins / Q000378:metabolism; D011714:Pyrans / Q000097:blood*; D012701:Serotonin / Q000378:metabolism
D001095:Arachidonic Acids; D006880:Hydroxy Acids; D010545:Peroxides; D011453:Prostaglandins; D011714:Pyrans; D012701:Serotonin