Thromboxane A2 and prostaglandin H2: potent stimulators of the swine coronary artery.
Thromboxane A2 was generated by incubation of arachidonic acid with a suspension of human platelets. The filtrate contained 266 +/- 46 ng/ml (n=10) of thromboxane A2 and 25 ng/ml or less of prostaglandin endoperoxides (prostaglandins G2+H2). Thromboxane A2 was 2-10 times more potent than prostaglandin H2 and 9-102 times and 26-308 times more potent than prostaglandins E2 and F2alpha, respectively, in causing contractions of the superfused swine coronary artery.
D000818:Animals; D001095:Arachidonic Acids / Q000378:metabolism; D001158:Arteries / Q000187:drug effects; D001779:Blood Coagulation Factors / Q000096:biosynthesis; D001792:Blood Platelets / Q000378:metabolism; D003331:Coronary Vessels / Q000187:drug effects; D006880:Hydroxy Acids / Q000096:biosynthesis / Q000494:pharmacology*; D009119:Muscle Contraction / Q000187:drug effects; D009130:Muscle, Smooth / Q000187:drug effects; D011453:Prostaglandins / Q000494:pharmacology*; D011458:Prostaglandins E / Q000494:pharmacology; D011460:Prostaglandins F / Q000494:pharmacology; D011714:Pyrans / Q000096:biosynthesis / Q000494:pharmacology*; D013552:Swine
D001095:Arachidonic Acids; D001779:Blood Coagulation Factors; D006880:Hydroxy Acids; D011453:Prostaglandins; D011458:Prostaglandins E; D011460:Prostaglandins F; D011714:Pyrans