Precursors and metabolites of 5-hydroxytryptamine and dopamine in the ventricular cerebrospinal fluid of psychiatric patients.
Tryptophan and 5-hydroxyindoleacetic acid (precursor and metabolite respectively of 5-hydroxytryptamine) were determined in ventricular CSF of psychiatric patients undergoing stereotactic subcaudate tractotomy. Tyrosine and homovanillic acid (precursor and metabolite respectively of dopamine) were also determined. Results suggest an association between affective state and the above precursor amino acids with lower concentrations in primary depression and higher ones when anxiety or agitation predominate. This leads to lower 5-hydroxyindoleacetic acid concentrations in depression and higher concentrations in anxiety and agitation.
D000328:Adult; D000368:Aged; D001008:Anxiety Disorders / Q000134:cerebrospinal fluid; D001927:Brain Diseases; D002552:Cerebral Ventricles / Q000378:metabolism; D003863:Depression / Q000134:cerebrospinal fluid; D005260:Female; D006719:Homovanillic Acid / Q000134:cerebrospinal fluid*; D006801:Humans; D006897:Hydroxyindoleacetic Acid / Q000134:cerebrospinal fluid*; D008297:Male; D001523:Mental Disorders / Q000134:cerebrospinal fluid*; D008875:Middle Aged; D009771:Obsessive-Compulsive Disorder / Q000134:cerebrospinal fluid; D010648:Phenylacetates / Q000134:cerebrospinal fluid*; D012559:Schizophrenia / Q000134:cerebrospinal fluid; D014364:Tryptophan / Q000134:cerebrospinal fluid*; D014443:Tyrosine / Q000134:cerebrospinal fluid*
D010648:Phenylacetates; D014443:Tyrosine; D006897:Hydroxyindoleacetic Acid; D014364:Tryptophan; D006719:Homovanillic Acid