[Conditioning of emotional behavior originating at the hypothalamus. (2) Effects of drugs on conflict-induced behavior models].
We attempted induction of the conflict behavior by the locus pattern, thumping and conditioning under hypothalamic stimulation in rabbits. Flight was classified as continuous and non-continuous. Thumping was elicited post stimulus. Conditioning responses were obtained during the autonomic-somatic responses, continuous run and non-continuous run. All drugs were administrated orally. Dosage of each drug used in this experiment was calculated by determining the dosage which caused the same degree of muscle relaxation and sedative action in mice (see, Fig. 1) or general behavior in rabbits. Diazepam 5 mg/kg, chlordiazepoxide 10 mg/kg and nitrazepam 1 mg/kg caused non-continuous flight in the smooth run, but chlorpromazine 5 mg/kg induced continuous run with snarling. Methamphethamine 5 mg/kg induced continuous run and autonomic-somatic tonus pattern, and phenobarbital-Na 30 mg/kg depressed the animal to the stage of flight. Diazepam, chlordiazepoxide and phenobarbital-Na inhibited thumping, while chlorpromazine, nitrazepam and methamphethamine increased the incidence of thumping. Chlorpromazine transformed the non-continuous run into autonomic-somatic responses of conditioning. Diazepam transformed the non-continuous run into a continuous one. Phenobarbital-Na transformed the non-continuous run into autonomic-somatic responses. Methamphethamine transformed the non-continuous run into a withdrawal response. It would thus appear that the non-continuous flight, thumping and the non-continuous run conditioning are forms of conflict in behavior which can be applied to study of emotional response with psychotropic drugs.
D000818:Animals; D002707:Chlordiazepoxide / Q000494:pharmacology; D002746:Chlorpromazine / Q000494:pharmacology; D003213:Conditioning, Psychological / Q000187:drug effects*; D003220:Conflict, Psychological; D003975:Diazepam / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D004558:Electric Stimulation; D004644:Emotions / Q000187:drug effects*; D004924:Escape Reaction / Q000187:drug effects; D006993:Hypnotics and Sedatives; D007031:Hypothalamus / Q000502:physiology*; D008297:Male; D008694:Methamphetamine / Q000494:pharmacology; D051379:Mice; D009567:Nitrazepam / Q000494:pharmacology; D010634:Phenobarbital / Q000494:pharmacology; D011619:Psychotropic Drugs / Q000494:pharmacology*; D011817:Rabbits
D006993:Hypnotics and Sedatives; D011619:Psychotropic Drugs; D008694:Methamphetamine; D002707:Chlordiazepoxide; D009567:Nitrazepam; D003975:Diazepam; D002746:Chlorpromazine; D010634:Phenobarbital