The effect of uropolinum, a diatrizoate contrast medium, on erythrocyte metabolism.
In the presence of Uropolinum (sodium and N-methylglucamine diatrizoate) the lactate production of erythrocytes was decreased in half of the cases studied. The addition of albumin showed a protective effect on glycolysis of red blood cells. A decrease in glutathione reductase and increase in glucose-6-phosphate dehydrogenase activity was observed in all cases. Acethylcholinesterase activity was unaffected by Uropolinum. The activities of phosphohexose isomerase, phosphofructokinase. aldolase and ATP-ase were decreased in some subjects and increased in the others. It may be attributed to individual sensitivity of some subjects to diatrizoates and is consistent with clinical observations.
D001786:Blood Glucose / Q000378:metabolism; D003973:Diatrizoate / Q000378:metabolism*; D004912:Erythrocytes / Q000201:enzymology / Q000378:metabolism*; D006801:Humans; D007773:Lactates / Q000096:biosynthesis; D008623:Mercaptoethanol / Q000494:pharmacology; D012709:Serum Albumin / Q000494:pharmacology
D001786:Blood Glucose; D007773:Lactates; D012709:Serum Albumin; D003973:Diatrizoate; D008623:Mercaptoethanol