[On improved prophylaxis of endogenous-phasic psychoses: aspects of parallel determination of lithium in serum and erythrocytes (author's transl)].
In 30% of the psychiatric patients investigated the lithium concentration in erythrocytes (RBC-lithium) is a more reliable indicator for the evaluation of the clinical response and the risk of toxicity. After lithium administration the lithium RBC levels increased within the first three weeks. Lithium RBC/plasma ratios are not different between unipolar, bipolar and schizo-affective psychoses. It was found that low lithium RBC/plasma ratios correspond with low monoamine oxidase (MAO) activity in platelets.
D000342:Affective Symptoms / Q000097:blood / Q000188:drug therapy*; D001714:Bipolar Disorder / Q000188:drug therapy; D001792:Blood Platelets / Q000201:enzymology; D004341:Drug Evaluation; D004912:Erythrocytes / Q000032:analysis*; D006801:Humans; D008094:Lithium / Q000097:blood* / Q000627:therapeutic use; D008995:Monoamine Oxidase / Q000097:blood; D010949:Plasma / Q000032:analysis; D012559:Schizophrenia / Q000188:drug therapy
D008094:Lithium; D008995:Monoamine Oxidase
Zur Verbesserung der Lithiumprophylaxe endogen phasischer Psychosen: Aspekte der para;;e;em Lithiumbestimmung im Serum und in Erythrozyten