Prefrontal cortex and neostriatum self-stimulation in the rat: differential effects produced by apomorphine.
In a dose-response experiment, the effects of intraperitoneal injections of the dopamine receptor agonist, apomorphine (0.075, 0.15, 0.3, 0.6 and 1.2 mg/kg) were studied on self-stimulation elicited from electrodes implanted in the medial and sulcal prefrontal cortex and caudate-putamen in the rat. From the medial and sulcal prefrontal cortex electrodes, apomorphine produced a dose-related decrease of self-stimulation rate which was consistent across animals. From the caudate-putamen electrodes, on the contrary, apomorphine produced a facilitatory effect in the majority of the animals at one or more doses, however, at other doses a decreased self-stimulation rate was observed. The clear and consistent effects of apomorphine on self-stimulation of the prefrontal cortex, together with other experimental evidence in the same line, suggest that dopamine is mediating self-stimulation of this cortical area.
D000818:Animals; D001058:Apomorphine / Q000494:pharmacology*; D002421:Caudate Nucleus / Q000187:drug effects*; D002540:Cerebral Cortex / Q000187:drug effects* / Q000502:physiology; D003342:Corpus Striatum / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D008297:Male; D011699:Putamen / Q000187:drug effects*; D051381:Rats; D011954:Receptors, Dopamine / Q000187:drug effects*; D012653:Self Stimulation / Q000187:drug effects* / Q000502:physiology
D011954:Receptors, Dopamine; D001058:Apomorphine