[Glycoside induced intestinal ischemia. Therapeutic possibilities (author's transl)].
Intestinal infarction in the absence of organic vascular occlusion received increasing attention in recent years. There is strong evidence from experimental work and clinical observations that cardiac glycosides may play an important role in the pathophysiology of this disorder. Our experiments using the so called mechanical ventricular massage confirm this theory. We could demonstrate that the decrease in mesenteric arterial perfusion following the i.v. administration of ouabain is caused by extracardiac effects of the glycoside on vascular smooth muscle. The Ca++ -antagonistic compound (Verapamil) blocks and reverses the Ca++-synergistic action of the glycoside independent of the time of injection.
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D002301:Cardiac Glycosides / Q000009:adverse effects* / Q000494:pharmacology; D002496:Central Venous Pressure / Q000187:drug effects; D005260:Female; D006336:Heart Massage; D007238:Infarction / Q000139:chemically induced* / Q000628:therapy; D007422:Intestines / Q000098:blood supply*; D008297:Male; D008638:Mesenteric Arteries / Q000503:physiopathology; D008641:Mesenteric Vascular Occlusion / Q000139:chemically induced / Q000628:therapy; D010042:Ouabain / Q000009:adverse effects; D012039:Regional Blood Flow / Q000187:drug effects; D013328:Strophanthins / Q000494:pharmacology; D014655:Vascular Resistance / Q000187:drug effects; D014700:Verapamil / Q000494:pharmacology
D002301:Cardiac Glycosides; D013328:Strophanthins; D010042:Ouabain; D014700:Verapamil
Glykosidbedingte Durchblutungsstörungen des Darms und Möglichkeiten therapeutischer Beeinflussung