Localization of factors controlling spermatogenesis in the nonfluorescent portion of the human Y chromosome long arm.
A deletion of the Y chromosome at the distal portion of band q11 was found in 6 men with normal male habitus but with azoospermia. Five of them were found during a survey of 1170 subfertile males while the sixth was karyotyped because of slight bone abnormalities. These findings, together with a review of the literature, suggest that on the distal portion of the nonfluoresecent segment of the long arm of the Y, factors are located controlling spermatogenesis.
D000328:Adult; D002872:Chromosome Deletion; D006801:Humans; D007248:Infertility, Male / Q000235:genetics; D008297:Male; D012729:Sex Chromosome Aberrations; D012730:Sex Chromosomes; D013091:Spermatogenesis