title: Studies on the mechanism of action of amantadine.
abstract: 1 The effect of amantadine hydrochloride on various aspects of catecholamine metabolism in the rat brain has been investigated. 2 Amantadine failed to have any significant effect on brain concentrations of dopamine or noradrenaline even when administered daily for 9 days. 3 Amantadine had no effect on the rate of decline of noradrenaline and dopamine concentrations after alpha-methyl-p-tyrosine. 4 In vitro amantadine inhibited dopamine uptake into synaptosomes only at high concentrations, and caused little release of dopamine from synaptosomes. 5 There is no evidence from these results to suggest that the anti-Parkinsonian effect of amantadine is related to an action on dopaminergic mechanisms.
mesh_terms: D000547:Amantadine / Q000494:pharmacology*; D000818:Animals; D001921:Brain / Q000378:metabolism / Q000648:ultrastructure; D004298:Dopamine / Q000378:metabolism; D066298:In Vitro Techniques; D008297:Male; D009638:Norepinephrine / Q000378:metabolism; D051381:Rats; D013574:Synaptosomes / Q000378:metabolism; D013997:Time Factors
chemical_list: D000547:Amantadine; D004298:Dopamine; D009638:Norepinephrine