title: Urinary outputs of oxalate, calcium, and magnesium in children with intestinal disorders. Potential cause of renal calculi.
abstract: 24-hour urinary outputs of oxalate, calcium, and magnesium have been determined in a total of 62 children aged 3 months to 17 years who fell into the following groups: (i) 16 normal controls, (ii) 3 with primary hyperoxaluria, (iii) 9 with small and/or large intestinal resections, (iv) 9 with untreated coeliac disease, (v) 5 with pancreatic dysfunction, and (vi) a miscellaneous group of 20 children with a variety of intestinal disorders. Taken as a whole, 58% of patients with intestinal disorders had hyperoxaluria, and of these 7% had urinary outputs of oxalate which fell within the range seen in primary hyperoxaluria. The proportion of children with hyperoxaluria in the different diagnostic groups was as follows: intestinal resections (78%), coeliac disease (67%), pancreatic dysfunction (80%), and miscellaneous (45%). 35% of the patients with hyperoxaluria had hypercalciuria, whereas magnesium excretion was normal in all subjects studied. In 2 patients treatment of the underlying condition was accompanied by a return of oxalate excretion to normal. These results indicate that hyperoxaluria and hypercalciuria are common in children with a variety of intestinal disorders, and that such children may be at risk of developing renal calculi without early diagnosis and treatment.
mesh_terms: D000293:Adolescent; D002118:Calcium / Q000652:urine*; D002446:Celiac Disease / Q000178:diet therapy / Q000652:urine; D002648:Child; D002675:Child, Preschool; D003106:Colon / Q000378:metabolism; D005983:Glutens; D006801:Humans; D007223:Infant; D007408:Intestinal Absorption; D007410:Intestinal Diseases / Q000378:metabolism / Q000652:urine*; D007669:Kidney Calculi / Q000209:etiology; D008107:Liver Diseases / Q000652:urine; D008274:Magnesium / Q000652:urine*; D010070:Oxalates / Q000378:metabolism / Q000652:urine*; D010182:Pancreatic Diseases / Q000628:therapy / Q000652:urine
chemical_list: D010070:Oxalates; D005983:Glutens; D008274:Magnesium; D002118:Calcium