[Effects of anticholinergics and clozapine on the activation of the striatal dopaminergic system in the rat by haloperidol. Pharmacological findings (author's transl)].
Tardive dyskinesias, often seen in patients treated with classical neuroleptics, have been attributed to the development of receptor hypersensitivity following prolonged blockade of dopamine (DA)-receptors. In rats with unilateral striatal lesions, development of DA-receptor hypersensitivity following a 6-day treatment with haloperidol can be demonstrated by means of the increased turning response to apomorphine. Addition of atropine to the haloperidol treatment schedule resulted in a further increase in receptor sensitivity, but with a delay of 24 h in its appearance. This finding provides pharmacological support for the observation that tardive dyskinesias are more frequent and more severe in patients treated with a combination of a classical neuroleptic and an anticholinergic agent. Clozapine, despite its anticholinergic property, did not enhance the haloperidol-induced hypersensitivity.
D000818:Animals; D001058:Apomorphine; D001285:Atropine / Q000494:pharmacology*; D003024:Clozapine / Q000494:pharmacology*; D003342:Corpus Striatum / Q000378:metabolism*; D003984:Dibenzazepines / Q000494:pharmacology*; D004298:Dopamine / Q000378:metabolism*; D004357:Drug Synergism; D006220:Haloperidol / Q000494:pharmacology*; D006801:Humans; D009069:Movement Disorders / Q000139:chemically induced; D051381:Rats; D011955:Receptors, Drug / Q000187:drug effects; D013239:Stereotyped Behavior / Q000187:drug effects
D003984:Dibenzazepines; D011955:Receptors, Drug; D001285:Atropine; D003024:Clozapine; D006220:Haloperidol; D001058:Apomorphine; D004298:Dopamine
Einfluss von Anticholinergika sowie Clozapin auf die durch Haloperidol induzierte Aktivierung des dopaminergen Systems in Striatum der Ratte: Pharmakologische Ergebnisse