Patterns of changes in peripheral blood composition in the course of combination chemotherapy of cancer.
During MOPP (mechloretamine, vincristine, procarbasine and prednisone) chemotherapy in Hodgkin's disease a pattern of haematological injury develops gradually, and the period of maximal disturbances in peripheral blood parameters includes the last two or three months (the last 2 or 3 courses) of treatment with insufficient rebound between the courses. On the contrary, in the case of "synchronization" chemotherapy (vincristine and cyclophosphamide) in lung cancer a pattern of haematological injury develops rapidly, and the period of maximal disturbances in peripheral blood parameters takes only a few days, 7-12 days after each course, with sufficient or enhanced rebound between the courses. These differences are probably due to different scheduling of drugs in these methods of therapy.
D000328:Adult; D000368:Aged; D000970:Antineoplastic Agents / Q000009:adverse effects*; D003520:Cyclophosphamide / Q000009:adverse effects; D004359:Drug Therapy, Combination; D005260:Female; D006410:Hematopoiesis / Q000187:drug effects*; D006689:Hodgkin Disease / Q000097:blood* / Q000188:drug therapy; D006801:Humans; D007958:Leukocyte Count; D008175:Lung Neoplasms / Q000188:drug therapy; D008297:Male; D008466:Mechlorethamine / Q000009:adverse effects; D008875:Middle Aged; D011241:Prednisone / Q000009:adverse effects; D011344:Procarbazine / Q000009:adverse effects; D013997:Time Factors; D014750:Vincristine / Q000009:adverse effects
D000970:Antineoplastic Agents; D011344:Procarbazine; D008466:Mechlorethamine; D014750:Vincristine; D003520:Cyclophosphamide; D011241:Prednisone