A potent polyamine analog, spermindiol.
The effects of spermine, putrescine, and spermindiol on different nucleases were investigated. A highly active spermine analog, spermindiol, was synthesized, which markedly enhanced DNA hydrolysis by staphylococcal nuclease and spleen DNase II [EC 3.1.4.6] and RNA degradation by staphylococcal nuclease and pancreatic RNase A [EC 3.1.4.22]. Spermindiol also increased the melting temperature of calf thymus DNA.
D001665:Binding Sites; D004247:DNA; D003851:Deoxyribonucleases / Q000378:metabolism; D008836:Micrococcal Nuclease / Q000378:metabolism; D009691:Nucleic Acid Denaturation; D012313:RNA; D012260:Ribonucleases / Q000378:metabolism; D013096:Spermine / Q000031:analogs & derivatives* / Q000096:biosynthesis / Q000494:pharmacology; D013154:Spleen / Q000201:enzymology
D013096:Spermine; D012313:RNA; D004247:DNA; D003851:Deoxyribonucleases; D012260:Ribonucleases; D008836:Micrococcal Nuclease