[Stimulation of the inhibiting effect of interferon on the growth of ascitic carcinoma in relation to host responsiveness and cells].
When Krebs-2 ascitic carcinoma is transplanted to mice, administration of interferon may produce either a stimulating or an inhibiting effect on replication of carcinoma cells in the peritoneal cavity depending on the responsiveness of mice (intact or vaccinated with Newcastle disease virus) and the state of the transplanted cells ("common" or "tolerant"). Parallelism was observed in changes of the intensity of cell multiplications and indices of their enzymatic activity under the influence of exogenic interferon.
D000818:Animals; D002287:Carcinoma, Krebs 2 / Q000188:drug therapy / Q000276:immunology / Q000473:pathology*; D002455:Cell Division / Q000187:drug effects; D007372:Interferons / Q000494:pharmacology* / Q000627:therapeutic use; D051379:Mice; D009368:Neoplasm Transplantation; D009522:Newcastle disease virus / Q000276:immunology*
D007372:Interferons
Stimuliruiushchee ili ingibiruiushchee vliianie interferona na razvitie astsitnoĭ kartsinomy v zavismosti ot reaktivnosti organizma i kletok