title: Serum dilution neutralization test for California group virus identification and serology.
abstract: The serum dilution neutralization test was evaluated for serological diagnosis of California group arbovirus infections and identification of virus isolates. The technical advantages and the degree of subtype specificity of the serum dilution neutralization test over the hemagglutination inhibition test and the complement fixation test were demonstrated with paired specimens from human cases, single human survey sera, and sentinel rabbit sera. Twenty-one virus isolates from various geographical areas of the United States were also used to evaluate the efficacy of the serum dilution neutralization test for specific virus identification.
mesh_terms: D000293:Adolescent; D000328:Adult; D000914:Antibodies, Viral / Q000032:analysis; D001102:Arbovirus Infections / Q000175:diagnosis*; D002648:Child; D002675:Child, Preschool; D003168:Complement Fixation Tests; D003429:Cross Reactions; D003937:Diagnosis, Differential; D002141:Encephalitis Virus, California / Q000276:immunology*; D004668:Encephalitis Viruses / Q000276:immunology*; D005069:Evaluation Studies as Topic; D005260:Female; D006385:Hemagglutination Inhibition Tests; D006801:Humans; D007223:Infant; D008297:Male; D009500:Neutralization Tests
chemical_list: D000914:Antibodies, Viral