Treatment for trichuriasis with oxantel.
Single doses of oxantel given to 24 children and 37 adults with light to moderate infections of Trichuris trichiura effected cures in 20 of 26 (77%) trials with 10 mg/kg body weight, in 23 of 25 (92%) with 15 mg/kg, and in 10 of 10 trials with 20 mg/kg. In cases not cured, the egg-counts were reduced 50% to 91%. Side effects were not observed, and no drug-associated changes were detected by biochemical, hematologic, and urine examinations before and after treatment.
D000293:Adolescent; D000328:Adult; D000871:Anthelmintics / Q000008:administration & dosage / Q000627:therapeutic use*; D002648:Child; D005243:Feces / Q000469:parasitology; D006801:Humans; D011715:Pyrantel / Q000031:analogs & derivatives; D011743:Pyrimidines / Q000008:administration & dosage / Q000627:therapeutic use*; D013343:Styrenes / Q000008:administration & dosage / Q000627:therapeutic use; D014257:Trichuriasis / Q000188:drug therapy* / Q000469:parasitology; D014258:Trichuris
D000871:Anthelmintics; D011743:Pyrimidines; D013343:Styrenes; D011715:Pyrantel; C003407:oxantel