Nutritional studies of 3,5-dimethyoxy salicylic acid (antithiamine) on rat as well as on the growth of S. aureus.
1. The growth of rats treated with 3,5-dimethyoxy salicylic acid was retarded in comparison to that of normal rats. 2. The free cholesterol level of plasma of rats treated with 3,5-dimethoxy salicylic acid diminished while the pyruvate level of erythrocyte under the same condition increased in comparison with their normal levels; but on administration of thiamine both the cholesterol and pyruvate levels became normal. 3. The growth of a thiamine dependent strain of S. aureus was retarded when the organism was incubated in the medium containing 3,5-dimethoxy salicylic acid and this growth can be restored with the supplementation of thiamine in the medium.
D000818:Animals; D001835:Body Weight / Q000187:drug effects; D002784:Cholesterol / Q000097:blood; D004912:Erythrocytes / Q000378:metabolism; D006128:Growth / Q000187:drug effects*; D008297:Male; D011773:Pyruvates / Q000097:blood; D051381:Rats; D012459:Salicylates / Q000494:pharmacology*; D013211:Staphylococcus aureus / Q000187:drug effects* / Q000254:growth & development; D013831:Thiamine / Q000037:antagonists & inhibitors* / Q000494:pharmacology
D011773:Pyruvates; D012459:Salicylates; D002784:Cholesterol; D013831:Thiamine