Effect of succinic semialdehyde on seizure caused by vitamin B6 antagonists.
Since gamma-hydroxybutyric acid (GHB) is known to be an effective anesthetic adjuvant in animal and a natural metabolite of succinic semialdehyde (SSA), the effect of SSA and GHB on the convulsive action of vitamin B6 antagonists was studied using the onset of seizure as a parameter. The administration of SSA and GHB to mice protected them against the convulsive action of B6 antagonist, such as castrix (2-chloro-4-dimethyl-6-methylpyrimidine), thiosemicarbazide, or penicillamine. The anticonvulsant effect of SSA seems to be due to an increase in brain levels of GHB converted in vivo from SSA.
D000447:Aldehydes / Q000378:metabolism; D000818:Animals; D006885:Hydroxybutyrates / Q000627:therapeutic use*; D008297:Male; D051379:Mice; D010396:Penicillamine; D011736:Pyridoxine / Q000037:antagonists & inhibitors*; D011743:Pyrimidines; D012640:Seizures / Q000139:chemically induced / Q000517:prevention & control*; D012663:Semicarbazides; D013386:Succinates / Q000378:metabolism*; D005680:gamma-Aminobutyric Acid / Q000031:analogs & derivatives
D000447:Aldehydes; D006885:Hydroxybutyrates; D011743:Pyrimidines; D012663:Semicarbazides; D013386:Succinates; D005680:gamma-Aminobutyric Acid; D010396:Penicillamine; D011736:Pyridoxine; C009338:succinic semialdehyde