Antibiotics produced by Streptomyces ficellus II. Feldamycin and nojirimycin.
Feldamycin, a new antibacterial agent, and nojirimycin, a previously described antibiotic have been isolated from cultures of Streptomyces ficellus. Feldamycin, C17H25N7O5, is an amphoteric compound which inhibits a variety of bacteria in vitro but is found to be ineffective in the treatment of experimental bacterial infections in mice. Nojirimycin (5-amino-5-deoxy-D-glucose) has been isolated previously from cultures of several species of streptomycetes.
D000818:Animals; D000900:Anti-Bacterial Agents / Q000032:analysis / Q000096:biosynthesis* / Q000494:pharmacology; D000903:Antibiotics, Antineoplastic / Q000627:therapeutic use; D001424:Bacterial Infections / Q000517:prevention & control; D055598:Chemical Phenomena; D002621:Chemistry; D005285:Fermentation; D005658:Fungi / Q000187:drug effects; D007939:Leukemia L1210 / Q000188:drug therapy; D051379:Mice; D013302:Streptomyces / Q000378:metabolism*; D014780:Viruses / Q000187:drug effects
D000900:Anti-Bacterial Agents; D000903:Antibiotics, Antineoplastic