Postradiation motor neuron syndrome.
We report an unusual case of selective lower motor neuron syndrome (MNS) complicating whole neuraxis radiation therapy. Only three well-documented similar cases have been found in a thorough review of the literature. The syndrome has a stereotyped time course and is self-limited. We discuss here possible pathogenetic mechanisms and their relationship to motor neuron disease.
D000293:Adolescent; D002528:Cerebellar Neoplasms / Q000532:radiotherapy; D005260:Female; D006801:Humans; D007049:Iatrogenic Disease; D009046:Motor Neurons; D009468:Neuromuscular Diseases / Q000209:etiology* / Q000503:physiopathology; D011832:Radiation Injuries / Q000503:physiopathology; D011878:Radiotherapy / Q000009:adverse effects; D013577:Syndrome; D013997:Time Factors