title: Aminopyrine disposition: studies on breath, saliva, and urine of normal subjects and patients with liver disease.
abstract: To investigate aminopyrine disposition, breath, saliva, and urine were collected from 25 control patients, 15 patients with hepatocellular disease, and 26 patients with hepatic neoplasm after oral administration of 2 muCi [14C]aminopyrine. The percentage 14C excreted in breath 14CO2 in 2 hr (aminopyrine breath test, ABT) correlated with the breath 14CO2 elimination rate (r = 0.92, p less than 0.01), with the aminopyrine metabolic clearance rate (MCR) (r = 0.85, p less than 0.01), and with the plasma half-life of 4-aminoantipyrine (r = -0.54, p less than 0.05). The ABT permits study of aminopyrine disposition with simplicity, accuracy, and safety.
mesh_terms: D000328:Adult; D000368:Aged; D000632:Aminopyrine / Q000378:metabolism* / Q000652:urine; D001944:Breath Tests; D002245:Carbon Dioxide / Q000378:metabolism; D002250:Carbon Radioisotopes; D006207:Half-Life; D006525:Hepatitis, Viral, Human / Q000378:metabolism; D006801:Humans; D008103:Liver Cirrhosis / Q000378:metabolism; D008107:Liver Diseases / Q000378:metabolism*; D008113:Liver Neoplasms / Q000378:metabolism; D008657:Metabolic Clearance Rate; D008722:Methods; D008875:Middle Aged; D012463:Saliva / Q000378:metabolism*
chemical_list: D002250:Carbon Radioisotopes; D000632:Aminopyrine; D002245:Carbon Dioxide