Effect of adriamycin on the activity of the succinate dehydrogenase-coenzyme Q10 reductase of the rabbit myocardium.
Rabbits were injected with adriamycin 3 days/week/7 weeks. Heart tissues of treated rabbits showed myocardial degeneration, but the tissues of controls were normal. The deficiency in the activity of the succinate dehydrogenase-coenzyme Q10 reductase in the heart tissues of the rabbits treated with adriamycin was higher (0.001 less than P less than 0.01) than that for control tissues. These data indicate a correlation of at least a part of the cardiotoxicity of adriamycin in cancer patients to inhibition of CoQ10-enzymes, since coenzyme Q10 is indispensable to bioenergetics in the myocardium of both humans and rabbit.
D000818:Animals; D003864:Depression, Chemical; D004317:Doxorubicin / Q000494:pharmacology*; D006321:Heart / Q000187:drug effects*; D008297:Male; D008928:Mitochondria / Q000187:drug effects* / Q000201:enzymology; D009206:Myocardium / Q000201:enzymology / Q000648:ultrastructure; D011817:Rabbits; D013385:Succinate Dehydrogenase / Q000378:metabolism*
D004317:Doxorubicin; D013385:Succinate Dehydrogenase