title: [Biotransformation of halogen anesthetics and liver toxicity].
abstract: The authors attempt to explain halothane-induced hepatitis by a mechanism involving direct toxicity of a metabolite of this halogen compound. This implies a genetically determined metabolic disturbance or an increase in metabolic rate through previous enzyme induction (repeated anesthesia with halogen compounds).
mesh_terms: D000777:Anesthetics / Q000009:adverse effects / Q000378:metabolism*; D000818:Animals; D001711:Biotransformation; D004737:Enflurane / Q000378:metabolism; D006219:Halogens / Q000009:adverse effects / Q000378:metabolism*; D006221:Halothane / Q000378:metabolism; D006801:Humans; D008099:Liver / Q000187:drug effects* / Q000378:metabolism; D008733:Methoxyflurane / Q000378:metabolism
chemical_list: D000777:Anesthetics; D006219:Halogens; D008733:Methoxyflurane; D004737:Enflurane; D006221:Halothane
vernacular_title: Biotransformation des anesthésiques halogénés et hépatoxicite