[Toxic effect of methanol under conditions of complete and deficient protein nutrition].
In experiments with albino rats receiving complete and protein-deficient nutrition the effect of different doses of methanol (10,100 and 500 mg/kg) administered daily per os for a month was studied. Methanol was shown to display toxic hepatotropic action, producing in the liver a focal proteinic degeneration of the hepatocytic cytoplasm, causing changes in the activity of some microsomal enzymes and enlarging the average size of hepatic cells (early age-specific changes). The damaging action of methanol manifested itself in a particularly distinct fashion by depressing the synthesis of DNA, when used in large doses and against the background of a protein-deficient ration.
D000818:Animals; D056486:Chemical and Drug Induced Liver Injury / Q000150:complications / Q000209:etiology / Q000473:pathology; D008099:Liver / Q000201:enzymology / Q000473:pathology*; D008297:Male; D000432:Methanol / Q000506:poisoning*; D011488:Protein Deficiency / Q000150:complications* / Q000201:enzymology / Q000473:pathology; D051381:Rats
D000432:Methanol
Izuchenie toksicheskogo deĭstviia metanola v usloviiakh polnotsennogo i nedostatochnogo po belku pitaniia