Metabolism of calcium and magnesium in liver during acute thioacetamide intoxication.
The metabolism of calcium and magnesium in liver of thioacetamide treated rats has been studied. A change in the semipermeability of the cell membrane to calcium, magnesium, sodium and potassium was observed. The variations in the concentration of extra- and intracellular cations indicates that an undiscriminated in- and outflux of those ions takes place at the time of highest calcium deposition. This change in the cell membrane permeability seems to be related to modifications in the phospholipid metabolism. An increased incorporation of 32P into the acidic phospholipids (phosphatidyl ethanolamine and phosphatidyl serine) suggests their involvement in the physiological changes of the cell membrane. The results also point out the existence of a hormonally determined susceptibility of the cell membrane to undergo those changes.
D000081:Acetamides / Q000506:poisoning*; D000818:Animals; D002118:Calcium / Q000378:metabolism*; D002463:Cell Membrane Permeability / Q000187:drug effects; D056486:Chemical and Drug Induced Liver Injury / Q000378:metabolism*; D005260:Female; D008099:Liver / Q000378:metabolism*; D008274:Magnesium / Q000378:metabolism*; D008297:Male; D010714:Phosphatidylethanolamines / Q000096:biosynthesis; D010743:Phospholipids / Q000096:biosynthesis; D010758:Phosphorus / Q000378:metabolism; D011188:Potassium / Q000378:metabolism; D051381:Rats; D012737:Sex Factors; D012964:Sodium / Q000378:metabolism; D013347:Subcellular Fractions / Q000378:metabolism; D013853:Thioacetamide / Q000506:poisoning*
D000081:Acetamides; D010714:Phosphatidylethanolamines; D010743:Phospholipids; D013853:Thioacetamide; D010758:Phosphorus; D012964:Sodium; D008274:Magnesium; D011188:Potassium; D002118:Calcium