[Pharmacological studies of a new antitussive, 1-phenethyl-4-hydroxy-salicylamido-4-methyl-piperidine-hydrochloride (S 1592) (author's transl)].
1-Phenethyl-4-hydroxy-salicylamido-4-methylpiperidine-hydrochloride (S 1592) markedly inhibits coughing induced in laboratory animals by chemical or mechanical irritation of respiratory tract or by electrical stimulation of the superior laryngeal nerve. The drug has low acute toxicity in mice and rats. The new compound possesses bronchodilating and antianaphylactic properties and does not affect gastrointestinal propulsion. Cardiovascular effects are absent.
D000698:Analgesia; D000707:Anaphylaxis / Q000517:prevention & control; D000818:Animals; D000996:Antitussive Agents / Q000633:toxicity; D001831:Body Temperature / Q000187:drug effects; D001980:Bronchi / Q000187:drug effects; D002415:Cats; D003371:Cough / Q000517:prevention & control; D004285:Dogs; D005769:Gastrointestinal Motility / Q000187:drug effects; D006168:Guinea Pigs; D006439:Hemodynamics / Q000187:drug effects; D007928:Lethal Dose 50; D008297:Male; D051379:Mice; D009043:Motor Activity / Q000187:drug effects; D009048:Motor Skills / Q000187:drug effects; D009119:Muscle Contraction / Q000187:drug effects; D009129:Muscle Tonus / Q000187:drug effects; D009130:Muscle, Smooth / Q000187:drug effects; D010880:Piperidines / Q000494:pharmacology* / Q000633:toxicity; D051381:Rats; D012119:Respiration / Q000187:drug effects; D012457:Salicylamides / Q000494:pharmacology* / Q000633:toxicity; D012640:Seizures / Q000517:prevention & control; D012890:Sleep / Q000187:drug effects
D000996:Antitussive Agents; D010880:Piperidines; D012457:Salicylamides
Etudes pharmacologiques d'un nouvel antitussif: le phénéthyl-1 hydroxy-4 salicylamido méthyl-4 pipéridine, chlorhydrate (S 1592)