The influence of albumin degradation products on central effect of thiopental.
The influence of trypsin- and leukocyte-induced degradation products of albumin on the potency of thiopental action was studied. Degradation products of albumin increased the potency of this drug as evaluated by Lat's test, prolonged the duration of thiopental sleep and potentiated the hypothermic effects of thiopental. Thiopental action under the influence of albumin degradation products did not depend on the changes to accumunlation of this drug in the brain tissue.
D000818:Animals; D001921:Brain / Q000187:drug effects*; D001923:Brain Chemistry / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D005260:Female; D006801:Humans; D008297:Male; D009068:Movement / Q000187:drug effects; D051381:Rats; D012709:Serum Albumin / Q000494:pharmacology*; D012890:Sleep; D013874:Thiopental / Q000097:blood / Q000494:pharmacology*
D012709:Serum Albumin; D013874:Thiopental