An experimental model for inducing fetal hypotrophy in the rabbit.
Intravenous injection of a saponin-collargol solution into pregnant rabbits induced, in addition to haemolysis and decrease in body weight of the gravid animals, a dose-dependent intrauterine deficient development of the fetuses accompanied by pronounced general reduction in body weight and disproportionate growth of fetal organs. Brain, heart, lungs, and the kidneys to a lesser degree, were found to be comparatively heavier when compared to the total body weight. The reasons discussed are hypoxia-dependent deficiency in glycogen and glucose, nutritional factors resulting from malnutrition, intoxication, and placental insufficiency due to infarctions, particularly for groups II and III.
D000818:Animals; D001835:Body Weight / Q000187:drug effects; D005260:Female; D005333:Fetus / Q000187:drug effects*; D006461:Hemolysis / Q000187:drug effects; D008431:Maternal-Fetal Exchange; D009929:Organ Size / Q000187:drug effects; D010100:Oxygen / Q000494:pharmacology*; D011247:Pregnancy; D011817:Rabbits; D012503:Saponins / Q000494:pharmacology; D012834:Silver / Q000494:pharmacology
D012503:Saponins; D012834:Silver; D010100:Oxygen