Inhibition of glycolysis in brain by a phospholipid effect on interconversion of fructose phosphates. A possible regulatory control on utilization of glucose 6-phosphate.
Glucose 6-phosphate accumulation in 10,000 X g supernatant of rat brain was enhanced up to 16-fold by the addition of phosphatidylcholine, other common phospholipids, or linoleate. This glucose 6-phosphate is of endogenous origin via UDP-glucose and glucose 1-phosphate but not glucose. The accumulation is the result of inhibition of glycolysis by an effect of phospholipid on the interconversion of fructose 6-phosphate and fructose 1,6-bisphosphate. Brain is therefore capable of gluconeogenesis from fructose 1,6-bisphosphate. A regulatory function for phospholipid which coordinates glycolysis and other major routes of utilization of glucose 6-phosphate in brain, e.g. inositol synthesis, is proposed.
D000818:Animals; D001921:Brain / Q000187:drug effects / Q000378:metabolism*; D002118:Calcium / Q000494:pharmacology; D003840:Deoxycholic Acid / Q000494:pharmacology; D005636:Fructosephosphates / Q000378:metabolism*; D005958:Glucosephosphates / Q000378:metabolism*; D006019:Glycolysis / Q000187:drug effects*; D006598:Hexosediphosphates / Q000378:metabolism; D007700:Kinetics; D008041:Linoleic Acids / Q000494:pharmacology; D010713:Phosphatidylcholines / Q000494:pharmacology; D010743:Phospholipids / Q000494:pharmacology*; D051381:Rats
D005636:Fructosephosphates; D005958:Glucosephosphates; D006598:Hexosediphosphates; D008041:Linoleic Acids; D010713:Phosphatidylcholines; D010743:Phospholipids; D003840:Deoxycholic Acid; D002118:Calcium