The influence of some antidepressant drugs on cardiac function. III. Influence on the isolated heart and isolated coronary blood vessels.
Imipramine, nortriptyline and amitriptyline reduced coronary flow in experiments on the isolated heart muscle and raised the tone of isolated coronary blood vessels.
D000639:Amitriptyline / Q000494:pharmacology*; D000818:Animals; D002415:Cats; D003326:Coronary Circulation / Q000187:drug effects*; D003331:Coronary Vessels / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D006321:Heart / Q000187:drug effects*; D007099:Imipramine / Q000494:pharmacology*; D009200:Myocardial Contraction / Q000187:drug effects; D009661:Nortriptyline / Q000494:pharmacology*
D000639:Amitriptyline; D009661:Nortriptyline; D007099:Imipramine