Electronic volume analysis of L1210 chemotherapy.
The rapid analysis of in vivo chemotherapy on the L1210 ascites tumor grown in C57BL/6 X DBA/2F1 mice has been shown by means of an electronic volume analysis. The drugs were injected on the 4th day of tumor growth, and the cells in the peritoneal cavity were studied at 24-hr intervals on the 5th through 7th day. Using the electronic cell volume distributions, combined with labeling indices, cell morphology, and cell counts, it was found that the alkylating agents. 1,3-bis(2-chloroethyl)-1-nitrosourea and cyclophosphamide, at the dosages used, were more effective than the S-phase-specific drugs, palmitoyl ester of 1-beta-D-arabinofuranosylcytosine, vincristine, and methotrexate.
D000818:Animals; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D002330:Carmustine / Q000627:therapeutic use; D002452:Cell Count / Q000379:methods; D002455:Cell Division / Q000187:drug effects; D002470:Cell Survival; D003520:Cyclophosphamide / Q000627:therapeutic use; D003561:Cytarabine / Q000031:analogs & derivatives / Q000494:pharmacology / Q000627:therapeutic use; D004353:Drug Evaluation, Preclinical / Q000379:methods*; D004581:Electronics; D005260:Female; D007939:Leukemia L1210 / Q000188:drug therapy* / Q000473:pathology; D008727:Methotrexate / Q000494:pharmacology / Q000627:therapeutic use; D051379:Mice; D013997:Time Factors; D014750:Vincristine / Q000494:pharmacology / Q000627:therapeutic use
D000970:Antineoplastic Agents; D003561:Cytarabine; D014750:Vincristine; D003520:Cyclophosphamide; D002330:Carmustine; D008727:Methotrexate