title: Strongyle infections in ponies. II. Reinfection of treated animals.
abstract: Five of seven ponies whose strongyle worm burdens had previously been removed or markedly reduced by repeated thiabendazole treatments were reinfected with doses ranging from 100,000 to 500,000 small strongyle infective larvae. Reinfection of ponies resulted in the development of clinical signs characterized by abnormal feces, marked loss of weight and delayed shedding of winter hair coats. An abrupt increase in circulating eosinophils occurred during the first three weeks following reinfection. Patent infections developed in all ponies with worm eggs appearing in the feces from 12 to 15 weeks after receiving infective larvae. Worm egg outputs followed a cyclic pattern with approximately four to five peaks in egg output per year. There was an abrupt drop in the high worm egg counts in two untreated ponies approximately two and a half years after reinfection. No worms were recovered in the feces of these animals when they were subsequently treated, suggesting that a depletion in the number of inhibited larvae present in these ponies might have occurred.
mesh_terms: D000818:Animals; D001835:Body Weight; D005243:Feces / Q000469:parasitology; D006736:Horses; D010270:Parasite Egg Count; D012008:Recurrence; D013319:Strongyle Infections, Equine / Q000175:diagnosis / Q000188:drug therapy / Q000469:parasitology; D013827:Thiabendazole / Q000627:therapeutic use; D013997:Time Factors
chemical_list: D013827:Thiabendazole