Veno-occlusive disease of the liver associated with oral contraceptives: case report and review of literature.
This report concerns a young woman who, after taking a contraceptive preparation orally for three years, developed the Budd-Chiari syndrome as the result of a widespread chronic obliterative process involving the intrahepatic efferent venous system. Her prolonged course, which failed to respond to an end-to-side portacaval shunt procedure, mimicked chronic hepatitis evolving to cirrhosis. Additional noteworthy features were the presence of two small benign hepatic adenomas, observed both at biopsy and at necropsy, a lesion recently recognized as a complication of anovulatory drugs, and widespread hepatic calcifications found at autopsy.
D000236:Adenoma / Q000139:chemically induced; D000328:Adult; D001344:Autopsy; D006502:Budd-Chiari Syndrome / Q000139:chemically induced* / Q000473:pathology; D003276:Contraceptives, Oral / Q000009:adverse effects*; D003280:Contraceptives, Oral, Synthetic / Q000009:adverse effects*; D005260:Female; D006801:Humans; D008113:Liver Neoplasms / Q000139:chemically induced; D008656:Mestranol / Q000009:adverse effects*; D009639:Norethandrolone / Q000009:adverse effects; D011247:Pregnancy
D003276:Contraceptives, Oral; D003280:Contraceptives, Oral, Synthetic; D008656:Mestranol; D009639:Norethandrolone