[Clinical and anatomopathologic effect of Bisolvon in respiratory resuscitation].
N cyclohexyl-N-methyl-2 amino -3.5 dibromobenzyl, amine hydrochloride or Bisolvon is an alkaloid derived from vasicine whose fluidizing effects on bronchial secretions are well-known. This study which consisted in a randomization involved 40 patients that were being submitted to a respiratory reanimation, half of whom received Bisolvon intravenously. The patients were improved by the treatment with Bisolvon as can be seen from the following: - fewer bronchial aspirations; - less fluid secretions; - a decrease in alveolar cells; - an increase in bronchial cells; - a reduced increase in total mucus. These results evidence an original action ascribable to Bisolvon on the bronchial cell.
D001964:Bromhexine / Q000494:pharmacology*; D001980:Bronchi / Q000187:drug effects; D006801:Humans; D006813:Humidity; D001239:Inhalation; D009093:Mucus / Q000187:drug effects; D010100:Oxygen / Q000097:blood; D011650:Pulmonary Alveoli / Q000166:cytology / Q000187:drug effects; D012121:Respiration, Artificial; D013183:Sputum / Q000187:drug effects; D014783:Viscosity
D001964:Bromhexine; D010100:Oxygen
Effets cliniques et anatomo-pathologiques du Bisolvon en réanimation respiratoire