Decrease of serotonin N-acetyltransferase activity in rat pineal organs after treatment with prostaglandin synthesis inhibitor indomethacin.
Administration of indomethacin to rats abolished the cyclic AMP dependent, dark induced rise in serotonin N-acetyltransferase, presumably by inhibiting prostaglandin synthesis.
D000123:Acetyltransferases / Q000378:metabolism*; D000818:Animals; D002940:Circadian Rhythm / Q000187:drug effects; D003864:Depression, Chemical; D007213:Indomethacin / Q000494:pharmacology*; D008297:Male; D010870:Pineal Gland / Q000201:enzymology*; D051381:Rats; D012701:Serotonin / Q000378:metabolism
D012701:Serotonin; D000123:Acetyltransferases; D007213:Indomethacin