title: A systematic antilipidemic structure-activity relationship study was carried out on a series of alcoyl- and benzoyl-phenoxy-carboxylic acids.
abstract: A systematic antilipidemic structure-activity relationship study was carried out on a series of alcoyl- and benzoyl-phenoxy-carboxylic acids. The introduction of a p-chlorobenzoyl moiety into the original phenoxy-isobutyric acid enhanced antilipidemic activity significantly. Chlorine meta substitution or chlorine disubstitution abolished activity. Among the esters synthetized, the isopropylester has been selected for further studies.
mesh_terms: D000818:Animals; D002087:Butyrates / Q000138:chemical synthesis* / Q000494:pharmacology; D002784:Cholesterol / Q000097:blood; D000960:Hypolipidemic Agents / Q000138:chemical synthesis*; D007928:Lethal Dose 50; D008055:Lipids / Q000097:blood; D051379:Mice; D051381:Rats; D013329:Structure-Activity Relationship
chemical_list: D002087:Butyrates; D000960:Hypolipidemic Agents; D008055:Lipids; D002784:Cholesterol
vernacular_title: Antilipidemic Drugs. Part 1: Synthesis and structure-activity relationship of new alcoyl and benzoyl phenoxy carbocylic acids