title: Artificial circulation for resuscitation after prolonged clinical death caused by hypoxia.
abstract: The dynamics of dying and the subsequent recovery of the main vital functions such as cardiac performance, respiration and unconditioned reflexes were investigated in 24 dogs resuscitated by Bryukhonenko's method of artificial circulation after 13-15 min clinical death caused by asphyxia. Application of artificial circulation during asystole required a gradual increase for 2-3 min in the volume of perfusion to optimum levels, since too rapid an increase of blood flow resulted in secondary ventricular fibrillation. In conditions of resuscitation with high volumes of extracorporeal perfusion (exceeding 100 ml kg-1 min-1), fast return of vital functions, their subsequent normalization, and relatively smooth recovery, can be achieved. Decreasing the rate of blood flow to 60-80 ml kg-1 min-1 delays the recovery of vital functions of the resuscitated organism. Severe post-resuscitation disease develops with a fatal outcome. Resuscitation with flows of 40 ml kg-1 min-1 or less is ineffective. We concluded that successful resuscitation after clinical death caused by asphyxia was possible only when the blood flow was 1.2-1.5 times higher than the normal cardiac output.
mesh_terms: D000818:Animals; D001237:Asphyxia / Q000628:therapy; D001775:Blood Circulation; D004285:Dogs; D005260:Female; D006323:Heart Arrest / Q000628:therapy; D006439:Hemodynamics; D000860:Hypoxia / Q000628:therapy*; D008297:Male; D012119:Respiration; D012151:Resuscitation; D013997:Time Factors