[Studies on screening for cholesterol-lowering agents using phenyl- and chromane substituted compounds (author's transl)].
Sixteen phenyl compounds and twenty chromane compounds substituted by geranoyl, farnesoyl, phytonoyl, retinoyl and linolenoyl synthesized by Eisai Co., Ltd were used. Male mice were fed a cholesterol or a normal basal diet which 0.3% compound was added for 10 or 31 days. Effect of these compounds on the cholesterol level of serum and liver were examined and compared to that of CPIB. As a results of this series of experiments hypocholesteremic agents were screened as follows: 3 phenyl compounds (N76009, N76011, N76012), and 6 chromane compounds (N-76-H-23, N-76-H-25, N-76-H-27, N-76-H-35, N-76-H-37, N-76-H-38). Among these compounds, N-76-H-38, (formula: see text) was found to be the most favorable cholesterol-lowering agent.
D000818:Animals; D000924:Anticholesteremic Agents; D001555:Benzene Derivatives / Q000494:pharmacology*; D001578:Benzopyrans / Q000494:pharmacology*; D002784:Cholesterol / Q000097:blood; D002839:Chromans / Q000494:pharmacology*; D002994:Clofibrate / Q000494:pharmacology; D004353:Drug Evaluation, Preclinical; D008099:Liver / Q000187:drug effects / Q000378:metabolism; D008297:Male; D051379:Mice
D000924:Anticholesteremic Agents; D001555:Benzene Derivatives; D001578:Benzopyrans; D002839:Chromans; D002784:Cholesterol; D002994:Clofibrate