title: Phase I study of oral mitomycin C.
abstract: This study demonstrates that the gastrointestinal absorption of oral mitomycin C is variable and that myelosuppression correlates most closely with the peak serum concentration. The probable maximal-tolerated dose of oral mitomycin C is 45-50 mg/m2.
mesh_terms: D000284:Administration, Oral; D001791:Blood Platelet Disorders / Q000139:chemically induced; D004341:Drug Evaluation; D006801:Humans; D007970:Leukopenia / Q000139:chemically induced; D008937:Mitomycins / Q000008:administration & dosage / Q000627:therapeutic use* / Q000633:toxicity; D009369:Neoplasms / Q000188:drug therapy*
chemical_list: D008937:Mitomycins