[Lymphocyte sensitivity to brain specific glycoprotein in multiple sclerosis].
The lymphocytes of seven out of eight multiple sclerosis patients were sensitized to brain-specific glycoproteins that had been isolated from extracts of human white matter and purified by means of affinity chromatography utilizing specific antibodies as immunoadsorbents. The diagnosis of multiple sclerosis for the eighth patient, whose lymphocytes were not sensitized, was doubtful. A significant correlation between the severity of the disease and degree of lymphocyte sensitization was not obtained, although the most disabled patient showed the greatest sensitization.
D001921:Brain; D002464:Cell Migration Inhibition; D006023:Glycoproteins / Q000276:immunology*; D006801:Humans; D008213:Lymphocyte Activation; D008264:Macrophages; D009103:Multiple Sclerosis / Q000276:immunology*; D009419:Nerve Tissue Proteins / Q000276:immunology*
D006023:Glycoproteins; D009419:Nerve Tissue Proteins
Lymphocyten-Sensibilisierung gegen hirnspezifisches Glykoprotein bei Multipler Sklerose