The influence of angiotensin on central effect of acetylcholine in rats.
The influence of angiotensin on the central action of acetylcholine was studied in rats. It was shown that the action of acetylcholine was enhanced in animals treated simultaneously with angiotensin. Above phenomena were accompanied with the increase of "free" and "bound" acetylcholine in the brain of angiotensin treated rats. These observations indicate an interaction between angiotensin and acetylcholine in the CNS.
D000109:Acetylcholine / Q000378:metabolism / Q000494:pharmacology*; D000804:Angiotensin II / Q000494:pharmacology*; D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects; D001921:Brain / Q000187:drug effects* / Q000378:metabolism; D004347:Drug Interactions; D008297:Male; D010146:Pain / Q000503:physiopathology; D010830:Physostigmine / Q000494:pharmacology; D051381:Rats; D012640:Seizures / Q000139:chemically induced
D000804:Angiotensin II; D010830:Physostigmine; D000109:Acetylcholine