The discriminability of apsirin in arthritic and nonarthritic rats.
Aspirin, 56 mg/kg IP, was shown to be mildly, but significantly discriminable from saline in a group of 12 nonarthritic rats exposed to a 2-lever fixed ratio 10 drug discrimination protocol for 56 trials. In a concurrently-tested group of 12 rats made arthritic by injection of Mycobacterium butyricum into a hind paw, the discrimination of aspirin from saline was enhanced. The results exemplify how drug discriminability may vary depending on the pathological state of the subjects exposed to drug-discrimination training.
D000818:Animals; D001172:Arthritis, Rheumatoid / Q000175:diagnosis*; D001241:Aspirin; D003937:Diagnosis, Differential; D004193:Discrimination Learning; D004195:Disease Models, Animal; D008297:Male; D009161:Mycobacterium; D051381:Rats
D001241:Aspirin