Arrhythmias in the coronary-care unit. II. Physiologic bases of paroxysmal bradycardia-dependent A-V block.
Bradycardia-dependent A-V block during acute cardiac ischemia or injury is best explained by applying knowledge of basic cellular electrophysiology. Spontaneous diastolic depolarization during phase 4, plus a reduction in the magnitude of the transmembrane action potential are the pathophysiologic changes responsible for "phase-4 block".
D001919:Bradycardia / Q000503:physiopathology*; D002037:Bundle-Branch Block / Q000503:physiopathology; D004562:Electrocardiography; D006327:Heart Block / Q000503:physiopathology*; D006329:Heart Conduction System / Q000503:physiopathology; D006801:Humans; D008297:Male; D008875:Middle Aged; D013610:Tachycardia / Q000503:physiopathology