Method for assessment and comparison of the average rate of development of the phases of the contractile process in isolated smooth muscles.
In certain methodological setups the pharmacological agent is applied in a flowing fluid and washes the smooth-muscle preparation for a certain period of time. In such cases it is possible to observe differences in the slope of the curves of the contractile and relaxation phases of the contraction and appearance of the amplitude maximum at different moments in the total duration of the contractile process. The recording of the average development rates of the contraction phases, in addition to the commonly accepted indicator of th effect of the amplitude maximum, could give an additional characteristic to the action of the pharmacological substances. A method is proposed for determination of the average rates of the contractile and relaxation phases, as well as the relative dependence between them.
D066298:In Vitro Techniques; D008433:Mathematics; D008954:Models, Biological; D009119:Muscle Contraction / Q000187:drug effects; D009130:Muscle, Smooth / Q000502:physiology*; D013997:Time Factors