Reinvestigation of disulfiram-like biological activity of Coprinus atramentarius (Bull. ex Fr.) Fr. extracts.
A ninhydrin-positive aqueous fraction isolated from Coprinus atramentarius (Bull. ex Fr.) Fr. showed significant disulfiram-like activity in mice. The isolation of the fraction from the mushroom crude extract and a convenient pharmacological test for following the physiological activity in each fraction are described.
D000363:Agaricales / Q000032:analysis; D000818:Animals; D003302:Coprinus / Q000032:analysis; D004221:Disulfiram / Q000032:analysis / Q000494:pharmacology*; D004357:Drug Synergism; D000431:Ethanol / Q000494:pharmacology; D005260:Female; D008722:Methods; D051379:Mice; D010936:Plant Extracts / Q000032:analysis / Q000494:pharmacology*; D004856:Postural Balance / Q000187:drug effects; D012018:Reflex / Q000187:drug effects
D010936:Plant Extracts; D000431:Ethanol; D004221:Disulfiram