On the relationship between the activity of acetylation, growth of experimental tumors and efficacy of their suppression by hydrazine sulphate.
The growth of experimental tumors was found to involve an intensification of acetylation of sulphadimidine. Inhibition of carcinosarcoma Walker-256 by 88% and sarcoma-180 by 36% on treatment with 60 mg/kg body weight of hydrazine sulphate was followed by decreases in the rate of acetylation of 39.4 and 29.4%, respectively. When treatment failed to suppress tumor growth (sarcoma-45), acetylation level showed no decrease. The results point to a correlation between growth of tumors and their inhibition on the one hand and the level of acetylation on the other.
D000107:Acetylation; D000123:Acetyltransferases / Q000378:metabolism*; D000818:Animals; D002279:Carcinoma 256, Walker / Q000188:drug therapy / Q000201:enzymology / Q000378:metabolism*; D005260:Female; D006834:Hydrazines / Q000627:therapeutic use*; D051379:Mice; D009368:Neoplasm Transplantation; D051381:Rats; D013418:Sulfamethazine / Q000378:metabolism; D014184:Transplantation, Homologous
D006834:Hydrazines; D013418:Sulfamethazine; D000123:Acetyltransferases