[Bifunctional derivatives of N-nitroso-alkylurea].
Toxic cumulative and antitumor properties of bifunctional N-nitroso-alkylureas as compared with their monofunctional analogues were stuied. Newly produced compounds render a considerable antitumor effect on a number of experimental tumors. A conclusion may be drawn that despite changes in the chemical structure an active metabolic fragment both of mono- and bifunctional compounds is the same, as also evidenced by the cumulation index. However, inspite of a rather high antitumor activity of bifunctional compounds their chemotherapeutic indices are very low.
D000818:Animals; D000970:Antineoplastic Agents / Q000378:metabolism / Q000627:therapeutic use / Q000633:toxicity*; D002296:Carcinosarcoma / Q000188:drug therapy; D008545:Melanoma / Q000188:drug therapy; D051379:Mice; D009374:Neoplasms, Experimental / Q000188:drug therapy*; D009607:Nitrosourea Compounds / Q000378:metabolism / Q000627:therapeutic use / Q000633:toxicity*; D012509:Sarcoma / Q000188:drug therapy
D000970:Antineoplastic Agents; D009607:Nitrosourea Compounds
Bifunktsional'nye proizvodnye N-nitrozoalkilmochevin