Renal excretion of monovalent cations during functional adrenalectomy in conscious sheep.
In sheep with both adrenals removed and one re-implanted in the neck, functional adrenalectomy was produced in conscious undisturbed animals by occluding the blood supply to the transplanted gland. Functional adrenalectomy caused a fall in potassium excretion and a very large increase in sodium excretion and was reversed by aldosterone. Hydrocortisone infusions slightly increased potassium excretion and reduced solute-free water reabsorption. Preliminary evidence suggests that potassium secretion into urine was still occurring during the 8 hr period of adrenal occlusion and functional adrenalectomy.
D000315:Adrenalectomy; D000450:Aldosterone / Q000494:pharmacology; D000618:Aminohippuric Acids / Q000652:urine; D000818:Animals; D002712:Chlorides / Q000097:blood; D003345:Corticosterone / Q000494:pharmacology; D005260:Female; D006854:Hydrocortisone / Q000494:pharmacology; D007444:Inulin / Q000652:urine; D007668:Kidney / Q000187:drug effects / Q000502:physiology*; D011188:Potassium / Q000097:blood / Q000652:urine*; D012756:Sheep / Q000502:physiology*; D012964:Sodium / Q000652:urine*; D013997:Time Factors
D000618:Aminohippuric Acids; D002712:Chlorides; D000450:Aldosterone; D007444:Inulin; D012964:Sodium; D011188:Potassium; D003345:Corticosterone; D006854:Hydrocortisone