[Behavior of intestinal motility and serum gastrin level after administration of prostaglandin A1, E1 and F2alpha in recent mechanical ileus of the rabbit].
In a mechanical ileus model in 70 rabbits, the effects of PGF2alpha-infusions, PGE1- and PGA1-injections on jejunal pressure and serum gastrin levels were studied. PGF2alpha increases, whereas PGE1 inhibits jejunal motility. PGA1 produces no significant response. A modulation of neurotransmission is discussed. The serum gastrin levels can be decreased by PGE1-injections, whereas PGA1 effects only small decreases. The importance of the vagal mechanism for the release of gastrin is emphasized.
D000818:Animals; D005755:Gastrins / Q000097:blood*; D005769:Gastrointestinal Motility / Q000187:drug effects*; D007415:Intestinal Obstruction / Q000503:physiopathology*; D011453:Prostaglandins / Q000494:pharmacology*; D011454:Prostaglandins A / Q000008:administration & dosage / Q000494:pharmacology; D011458:Prostaglandins E / Q000008:administration & dosage / Q000494:pharmacology; D011460:Prostaglandins F / Q000008:administration & dosage / Q000494:pharmacology; D011817:Rabbits; D013997:Time Factors
D005755:Gastrins; D011453:Prostaglandins; D011454:Prostaglandins A; D011458:Prostaglandins E; D011460:Prostaglandins F
Verhalten von Darmmotilität und Serumgastrinspiegel unter Gabe von Prostaglandin A1, E1 und F2alpha beim frischen mechanischen Ileus des Kaninchens.