Enhancement of murine erythrocyte auto-antibody responses by Rauscher leukemogenic virus and by a weak allogeneic stimulation.
B6/c mice do not develop spontaneous positive direct Coomb's tests (DCT), but they are highly susceptible to the induction of erythrocyte auto-antibodies by immunization with cross reacting rat blood cells (36% positive DCT). Rauscher leukemogenic virus (RLV) does not directly induce DCT in these susceptible mice; neither does the inoculation of parental spleen cells. On the other hand both RLV and allogeneic stimulation by parental spleen cells enhance the incidence of the rat blood cell-induced DCT (up to 75% and 69% respectively). This is discussed in terms of a separate etiology to antinuclear and anti-erythrocyte auto-antibodies and of the possible mechanisms of auto-immune stimulation by oncogenic viruses or allogeneic stimulation.
D000818:Animals; D000917:Antibody Formation; D001323:Autoantibodies; D003298:Coombs Test; D004912:Erythrocytes / Q000276:immunology*; D005260:Female; D008297:Male; D051379:Mice; D051381:Rats; D011925:Rauscher Virus / Q000276:immunology*; D013154:Spleen / Q000276:immunology / Q000637:transplantation; D014184:Transplantation, Homologous
D001323:Autoantibodies