[Dissemination of carcinogenic H3-dialkylhydrazines in the neuro-endocrine system and their antigonadotropic effect in rats].
Three hours after the dimethylhydrazine-3H (DMH) treatment specific radioactivity in the male rat pituitary, adrenal cortex, and the testes was higher than in the liver by 53, 85, and 108%, respectively. Tritium incorporation into the hypothalamus was higher than that by the liver, cerebral cortex, and the brain stem by 33, 69, and 44%, respectively. Three hours after the diethyl-hydrazine-3H (DEH) treatment the specific activities of the pituitary and the testes in male rats were higher than that of the liver by 57 and 108%, respectively. A single DMH and DEH administration to male rats in a dose of 21 mg per kg body weight resulted in a significant decrease of the pituitary FSH level (by 63 and 53%, respectively). The data obtained were indicative of a marked influence of the carcinogenic dialkylhydrazines on the rat neuroendocrin system.
D000818:Animals; D003864:Depression, Chemical; D004127:Dimethylhydrazines / Q000378:metabolism / Q000494:pharmacology; D005260:Female; D005640:Follicle Stimulating Hormone / Q000378:metabolism*; D006834:Hydrazines / Q000378:metabolism* / Q000494:pharmacology; D007031:Hypothalamus / Q000378:metabolism; D008297:Male; D009928:Organ Specificity; D010902:Pituitary Gland / Q000187:drug effects*; D010903:Pituitary Gland, Anterior / Q000187:drug effects* / Q000378:metabolism; D051381:Rats; D012737:Sex Factors
D004127:Dimethylhydrazines; D006834:Hydrazines; D005640:Follicle Stimulating Hormone
Raspredelenie kantserogennykh dialkilgidrazinov-3H v neĭro-éndokrinooĭ sisteme i ikh antigonadotropnyĭ éffekt u krys