[On the simultaneous effects of ionising radiation and chemical agents on animal cells. 1st communication. Cytogenetic studies on X-rays and isonicotinic acid hydrazide in the Chinese hamster, Cricetulus griseus (author's transl)].
In bone marrow cells of Chinese hamsters enhanced chromosome damage is observed after 48 h treatment of the animals with isoniazid (INH) combined with X-rays only at much higher doses than normally applied in human therapy. Compared to X-ray-induced aberration levels, 125 mg/kg INH and 50 R given simultaneously increase the number of gaps and breaks, the latter being increased over-additively. This points to an interaction between both agents. The combined treatment changes the mitotic rate of the bone marrow as well.
D000818:Animals; D002869:Chromosome Aberrations; D002875:Chromosomes / Q000187:drug effects / Q000528:radiation effects; D006224:Cricetinae; D004305:Dose-Response Relationship, Drug; D004307:Dose-Response Relationship, Radiation; D005260:Female; D007538:Isoniazid / Q000494:pharmacology*; D008297:Male; D008938:Mitosis / Q000187:drug effects / Q000528:radiation effects; D011831:Radiation Genetics; D014965:X-Rays
D007538:Isoniazid
Uber die gleichzeitige Wirkung von ionisierender Strahlung und chemischen Agentien auf tierische Zellen. 1. Mitteilung: Zytogenetische Untersuchungen mit Röntgenstrahlen und Isonicotinsäurehydrazid (INH) beim Chinesischen Hamster, Cricetulus griseus