Effect of xanthine oxidase inhibitor on myocardial ischemia.
The xanthine oxidase inhibitor, 4-hydroxypyrazolo(3,4-d) pyrimidine (HPP), Allopurinol, caused augmentation of myocardial uptake of [3H] hypoxanthine, which was eventually completely incorporated into ATP. The decrease of [32P] orthophosphate incorporation into ATP induced by isoproterenol was restored by HPP administration.
D000255:Adenosine Triphosphate / Q000378:metabolism; D000493:Allopurinol / Q000494:pharmacology*; D000818:Animals; D003327:Coronary Disease / Q000378:metabolism*; D004195:Disease Models, Animal; D006321:Heart / Q000187:drug effects; D007042:Hypoxanthines / Q000378:metabolism; D007545:Isoproterenol / Q000494:pharmacology; D008099:Liver / Q000187:drug effects / Q000378:metabolism; D051379:Mice; D009206:Myocardium / Q000378:metabolism; D014969:Xanthine Oxidase / Q000037:antagonists & inhibitors*
D007042:Hypoxanthines; D000493:Allopurinol; D000255:Adenosine Triphosphate; D014969:Xanthine Oxidase; D007545:Isoproterenol