Development of collagenous fibres in autologous and preserved homologous tendon grafts.
Collagen synthesis has been studied in preserved autologous and homologous tendon grafts, applied in dogs. The stages of collagen morphogenesis observed in the synthetizing fibroblasts appearing in the decomposing original structure of the transplants as well as in the extracellular ground substance are described. The results suggest that autologous tendon grafts and homologous ones preserved by irradiation, stored in cold physiological saline and beta-propiolactone, are rebuilt within eight weeks; meanwhile the original collagenous fibre structure is decomposed. When other preserving procedures such as deep-freezing or gamma irradiation are applied recomposition of the graft is retarded or fails to occur; the result is a cicatrizing adhesion.
D000818:Animals; D003094:Collagen / Q000096:biosynthesis*; D004285:Dogs; D005121:Extremities / Q000601:surgery; D005347:Fibroblasts / Q000378:metabolism / Q000648:ultrastructure; D005615:Freezing; D005720:Gamma Rays; D011420:Propiolactone; D012965:Sodium Chloride; D013710:Tendons / Q000378:metabolism / Q000637:transplantation* / Q000648:ultrastructure; D013849:Thimerosal; D014021:Tissue Preservation; D014182:Transplantation, Autologous; D014184:Transplantation, Homologous
D013849:Thimerosal; D012965:Sodium Chloride; D011420:Propiolactone; D003094:Collagen