Remarks on the investigation of sodium nucleinate by means of the limulus amebocyte lysate test.
Results of investigations of sodium nucleinate by means of the limulus amebocyte lysate (LAL) test are described. It was found that the sensitivity of this new pyrogen test to bacterial lipopolysaccharides is nearly the same as to sodium nucleinate, which is prescribed as pyrogen standard in the Pharmacopeia of the German Democratic Republic and recommended as such in the Compendium Medicamentorum.
D000818:Animals; D001419:Bacteria; D001831:Body Temperature / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D006737:Horseshoe Crabs; D007202:Indicators and Reagents; D008070:Lipopolysaccharides / Q000494:pharmacology; D009696:Nucleic Acids / Q000032:analysis*; D011749:Pyrogens / Q000032:analysis*; D011817:Rabbits
D007202:Indicators and Reagents; D008070:Lipopolysaccharides; D009696:Nucleic Acids; D011749:Pyrogens