title: New hepato-protective agents. I. Maleopimaric acid-4alpha-carboxamides.
abstract: A number of amide derivatives of maleopimaric acid were synthesised and preliminary results on their protective activity against galactosamine-induced liver damage in the rat are described. The compounds (2, 6, 9 and 15) were found to display the highest level of protective activity producing significant lowering of serum GOT and GPT levels at a daily dose of 250-300 mg/kg. The LD50 of these compounds was typically in excess of 2000 mg/kg.
mesh_terms: D000818:Animals; D056486:Chemical and Drug Induced Liver Injury / Q000188:drug therapy*; D005688:Galactosamine; D007928:Lethal Dose 50; D008297:Male; D051381:Rats; D014315:Triterpenes / Q000138:chemical synthesis* / Q000627:therapeutic use
chemical_list: D014315:Triterpenes; D005688:Galactosamine