[Elimination of products of fluoracizine by the gastrointestinal tract in animals of different species].
A study on elimination of phthoracizine metabolites with feces of different animal species evidenced that bulk of its transformation products with an intact side-chain was contained in the feces of rats. In the feces of mice they are found in much smaller amount, while in rabbits they are practically untracable. The phthoracizine transformation products devoid of the side-chain are demonstrable both in rats and in other animal species either as traces or not definable at all. These phenomena are, apparently, to be attributed to a different ability of eliminating the phthoracizine biotransformation products with bile by different animal species, which, among other factors. is determined by the molecular weight of individual metabolites.
D000818:Animals; D001646:Bile / Q000378:metabolism; D001711:Biotransformation; D002855:Chromatography, Thin Layer; D004064:Digestive System / Q000378:metabolism*; D005243:Feces / Q000032:analysis*; D008297:Male; D051379:Mice; D010640:Phenothiazines / Q000378:metabolism*; D011817:Rabbits; D051381:Rats; D013454:Sulfoxides / Q000032:analysis / Q000378:metabolism
D010640:Phenothiazines; D013454:Sulfoxides; C001228:fluoracizine
Vyvedenie produktov prevrashcheniia ftoratsizina zheludochno-kishechnym traktom u zhivotnykh raznykh vidov