The influence of cystamine on pharmacokinetics and pharmacodynamics of thioridazine.
A study on the influence of cystamine on the kinetics and dynamics of the action of thioridazine has been carried out. Higher levels of this drug in the blood and lower levels in the brain tissue than those in unpremedicated rats were determined. Half-life of thioridazine underwent shortening from 2-55 hr to 1-05 hr. Excretion of thioridazine with bile was not significantly affected by premedication with cystamine. beta-Glucuronidase activity, after an initial drop on the first day following premedication, increased to levels higher than the control values. The dynamics of the action of the thioridazine were little affected. The cataleptic action of thioridazine was enhanced on the first day after premedication with cystamine. Thioridazine depressed exploratory activity in rats more significantly only during the first three days after cystamine premedication.
D000818:Animals; D001646:Bile / Q000378:metabolism; D001921:Brain / Q000378:metabolism; D002375:Catalepsy / Q000209:etiology; D003538:Cystamine / Q000494:pharmacology*; D005966:Glucuronidase / Q000378:metabolism; D006801:Humans; D007700:Kinetics; D008297:Male; D009068:Movement / Q000187:drug effects; D051381:Rats; D013881:Thioridazine / Q000097:blood / Q000494:pharmacology*
D005966:Glucuronidase; D013881:Thioridazine; D003538:Cystamine