[Effect of no-shpa, halidor, dibazol and euphylline on the fibrinogen content and fibrinolytic activity of blood].
With a single intravenous administration to albino rats of both sexes of nospanum and halidor in a dose of 2 mg/kg and dibazol--in 1 mg/kg produce activation of fibrinolysis, while euphylline in a dose of 12 mg/kg has no effect on this process. A protracted introduction by the subcuataneous route of halidor and nospanum in a dose of 10 mg/kg, of dibazol--in 5 mg/kg and of euphylline intramuscularly in a dose of 24 mg/kg depresses in animals the activity of the proteolytic process. It was found that in vitro nospanum, halidor and dibazol accelerate fibrinolysis, whereas the presence of euphylline in the blood plasma deccelerates this process.
D000628:Aminophylline / Q000008:administration & dosage / Q000494:pharmacology; D000818:Animals; D001537:Bencyclane / Q000008:administration & dosage / Q000494:pharmacology*; D001562:Benzimidazoles / Q000008:administration & dosage / Q000494:pharmacology; D003508:Cycloheptanes / Q000494:pharmacology*; D005260:Female; D005340:Fibrinogen / Q000032:analysis*; D005342:Fibrinolysis / Q000187:drug effects*; D066298:In Vitro Techniques; D007273:Injections, Intramuscular; D007275:Injections, Intravenous; D007279:Injections, Subcutaneous; D008297:Male; D010208:Papaverine / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000494:pharmacology; D051381:Rats; D014665:Vasodilator Agents / Q000008:administration & dosage / Q000494:pharmacology*
D001562:Benzimidazoles; D003508:Cycloheptanes; D014665:Vasodilator Agents; D000628:Aminophylline; D001537:Bencyclane; D005340:Fibrinogen; C005317:drotaverin; D010208:Papaverine
Vliianie no-shpy, galidora, dibazola i eufillina na soderzhanie fibrinogena i fibrinoliticheskuiu aktivnost' krovi