Ultrastructural investigation of peripheral arterial vessels in the cortex of rats with experimental hypertension.
The peripheral arterial blood vessels in the cerebrum of 36 experimental animals and 9 controls were studied by electron microscopy. In 5 rats of these renal hypertension was produced (the animals were sacrificed 3 to 15 days following the second operation). 24 animals were treated with depot angiotensin (0.02 to 2.5 mg/daily) for 3 hr up to 40 days, and 7 rats were neurotized for 1 to 41/2 months. The alterations of the cerebral vessels were distinctly different within these 3 models already in the early reactions. Thus, even in the first 14 days of the experiment with renal and angiotensinogenic hypertension alterations were observed that did never occur in the neurotized rats. There were always observed disturbances in permeability of the cerebral vessels, but they were never followed by such heavy wall insudations as usually noticed in the splanchnic vessels. The less frequent occurrence of hemorrhages and malacic processes in the rat brain is ascribed aside from the physiological properties of the brain supply, to genetic factors and the absence of arteriosclerotic burden to the vascular wall in the non-dietetically pretreated experimental animals.
D000804:Angiotensin II; D000818:Animals; D002199:Capillary Permeability; D002536:Cerebral Arteries / Q000648:ultrastructure*; D002540:Cerebral Cortex / Q000473:pathology; D006801:Humans; D006973:Hypertension / Q000139:chemically induced; D006977:Hypertension, Renal / Q000473:pathology*; D008297:Male; D009497:Neurotic Disorders; D051381:Rats
D000804:Angiotensin II