Participation of the thymus in the mechanism of bacterial discharge in carriers of typhoid bacteria.
Typhoid carrier state was reproduced in 54 rabbits by the injection of typhoid bacilli into the bone marrow of the femoral bone. The animals were divided into 3 groups. Those in the 1st and 2nd group were hydrocortisone and ATC before the infection, respectively, whereas the 3rd group served as control. The data obtained pointed to the great incidence of prolonged persistence of typhoid bacilli in the bone marrow. A much greater vital disharge of the causative agent with the feces was noted in the animals which before the infection were given hydrocortisone and ATC preparations depressing the functional activity of the thymus. In the second experimental series it was shown that ATC administration to rabbits on the 85th day after their intraosseous infection with typhoid bacilli promoted vital discharge of the causative agent with the feces. Problem of participation of the thymus in the mechanism of bacterial discharge in the carriers of typhoid bacilli are discussed.
D000818:Animals; D000961:Antilymphocyte Serum / Q000494:pharmacology; D002353:Carrier State / Q000382:microbiology / Q000503:physiopathology*; D005243:Feces / Q000382:microbiology; D006854:Hydrocortisone / Q000494:pharmacology; D011817:Rabbits; D013950:Thymus Gland / Q000276:immunology / Q000503:physiopathology*; D014435:Typhoid Fever / Q000382:microbiology / Q000503:physiopathology*
D000961:Antilymphocyte Serum; D006854:Hydrocortisone
Ob uchastii timusa v mekhanizme bakteriovydeleniia u nositeleĭ briushnotifoznykh bakteriĭ