title: Relationship of neonatal withdrawal to maternal methadone dose.
abstract: Neonatal withdrawal is described for a sample of 70 infants born to addicted women treated with methadone and comprehensive prenatal care. Although symptoms were manifested by over 90% of the infants, those born to women receiving near-term average doses of less than or equal to 20 mg/day had significantly less symptomatology, weight loss, and need for pharmacologic treatment than those of mothers still on higher doses. Reduction of methadone dose levels during the last 6 weeks of pregnancy to less than or equal to 20 mg/day appears to reduce the severity of neonatal withdrawal.
mesh_terms: D005260:Female; D006556:Heroin Dependence / Q000534:rehabilitation; D006801:Humans; D007231:Infant, Newborn; D007232:Infant, Newborn, Diseases / Q000209:etiology*; D008297:Male; D008691:Methadone / Q000008:administration & dosage / Q000009:adverse effects* / Q000627:therapeutic use; D011247:Pregnancy; D013375:Substance Withdrawal Syndrome / Q000453:epidemiology / Q000209:etiology*; D013997:Time Factors
chemical_list: D008691:Methadone