title: Onset of the vasoconstrictor effect of diflucortolone valerate, betamethasone valerate, and fluocinolone acetonide ointments applied for varying periods under occlusive dressings.
abstract: Evaluation of cutaneous vasoconstriction after applications of varying duration of topical corticoids on the flexor surfaces of the forearms of 20 patients with intact skin shows a significantly faster blanching effect with diflucortolone valerate ointment than with fluocinolone acetonide and betamethasone valerate ointments. Furthermore, the test shows that even for a highly active preparation, such as the diflucortolone valerate ointment, an application time of less than 3 h only exceptionally leads to vasoconstriction in the healthy skin.
mesh_terms: D000287:Administration, Topical; D000305:Adrenal Cortex Hormones / Q000008:administration & dosage; D001623:Betamethasone / Q000031:analogs & derivatives*; D001624:Betamethasone Valerate / Q000008:administration & dosage / Q000494:pharmacology*; D004060:Diflucortolone / Q000031:analogs & derivatives; D005446:Fluocinolone Acetonide / Q000008:administration & dosage / Q000494:pharmacology*; D005448:Fluocortolone / Q000031:analogs & derivatives / Q000494:pharmacology*; D006801:Humans; D009779:Occlusive Dressings; D009824:Ointments; D011244:Pregnadienediols / Q000494:pharmacology*; D012867:Skin / Q000098:blood supply* / Q000187:drug effects; D013997:Time Factors; D014666:Vasomotor System / Q000187:drug effects*
chemical_list: D000305:Adrenal Cortex Hormones; D009824:Ointments; D011244:Pregnadienediols; D005446:Fluocinolone Acetonide; C013486:diflucortolone valerate; D005448:Fluocortolone; D001623:Betamethasone; D001624:Betamethasone Valerate; D004060:Diflucortolone