[Age-corrected analysis of glucose tolerance in blood relations of patients with juvenile onset diabetes mellitus].
Intravenous glucose tolerance test(taking the age dependent variabilities of the glucose assimilation into consideration) was performed in 68 blood relations (30 siblings, 19 parents, 19 children) of 19 patients with juvenile onset diabetes mellitus (JODM). In 29,4% of the first degree relatives (in 20% of the siblings, in 42% of the parents and in 31,6% of the children) an abnormal glucose tolerance was found. Four of the siblings presented with insulin dependent JODM. Glucose intolerance was detected more often (42%) in siblings and parents of patients with later onset (after age 25) JODM than in siblings and parents of JODM-patients with onset before age 25 (20%).
D000293:Adolescent; D000328:Adult; D000367:Age Factors; D002648:Child; D003922:Diabetes Mellitus, Type 1 / Q000235:genetics* / Q000378:metabolism; D005260:Female; D005951:Glucose Tolerance Test; D006801:Humans; D008297:Male
Alterskorrigierte Analyse der Glukosetoleranz bei Blutsverwandten von Patienten mit Juvenile-Onset-Diabetes-mellitus