The effect of colloidal gold on blood coagulation.
Coagulation tests were carried out in rabbits after the intravenous administration of 2 mg/kg colloidal gold. Among the clotting factors, platelet Factor 3 and Factor XIII were found to be inhibited by the gold preparation. Gold at 2 mg/ml concentration induced an overall antithrombotic state in spite of an increased tendency to platelet aggregation. These experiments suggest a new possibility for the inhibition of Factor XIII and platelet Factor 3.
D000818:Animals; D001777:Blood Coagulation / Q000187:drug effects*; D003102:Colloids; D005169:Factor VIII; D005343:Fibrinolytic Agents; D006046:Gold / Q000494:pharmacology*; D010974:Platelet Aggregation / Q000187:drug effects; D010977:Platelet Factor 3; D011817:Rabbits
D003102:Colloids; D005343:Fibrinolytic Agents; D010977:Platelet Factor 3; D006046:Gold; D005169:Factor VIII