Synthesis and pharmacologic properties of pyridoyl derivatives of 3-methylaminoindole 2-methyltryptamine and isotryptamine.
Six new pyridoyl derivatives of 3-methylaminoindole, 2-methyltryptamine and isotryptamine were synthesized by condensation with chlorides of nicotinic and isonicotinic acids. The central action of these compounds seems to depress the central nervous system, as they reduce spontaneous motility (I, II, IV, V, VI) and amphetamine hypermotility (II, IV, V), prolong hexobarbital sleeping time (II, IV, V, VI), display analgesic action in the "writhing test" (all compounds) and in the "hot plate test" (IV, V). The compounds do not change body temperature and display no anticonvulsant action.
D000698:Analgesia; D000818:Animals; D001831:Body Temperature / Q000187:drug effects; D003913:Dextroamphetamine / Q000494:pharmacology; D004347:Drug Interactions; D005260:Female; D006591:Hexobarbital / Q000494:pharmacology; D007211:Indoles / Q000138:chemical synthesis / Q000494:pharmacology; D007928:Lethal Dose 50; D008297:Male; D051379:Mice; D009043:Motor Activity / Q000187:drug effects*; D011725:Pyridines / Q000138:chemical synthesis / Q000494:pharmacology; D012640:Seizures / Q000139:chemically induced; D012890:Sleep / Q000187:drug effects; D013329:Structure-Activity Relationship; D014363:Tryptamines / Q000138:chemical synthesis / Q000494:pharmacology
D007211:Indoles; D011725:Pyridines; D014363:Tryptamines; D006591:Hexobarbital; D003913:Dextroamphetamine