title: Prolactin regulation in 14 cases of galactorrhea and hypogonadism with minimal modifications of the sella turcica (author's transl).
abstract: In this study we report 13 cases of amenorrhea-galactorrhea and one of a male patient complaining of gynecomastia, galactorrhea, sexual impotence and sterility with oligoasthénospermy. In these cases, the size of the sella turcica was normal but we found a localized depression of the bottom of the sella turcica; these modifications were situated at the antero-inferior part of the sella in 12 cases and posteriorly in the 2 others. Basal prolactin level was higher than normal values in 13 cases (12 female and 1 male patients): individual values varied between 45 and 367 ng/ml. Nycthermeral rhythm disappeared in the 9 cases studied. Administration of L-Dopa (500 mg orally) significantly suppressed the prolactin values in the 11 cases studied. Oral water loading (20 ml/kg) left prolactin values unchanged (10 cases). After oral glucose tolerance test (1 g/kg) no significant systematic variation occurred. The increase of prolactin values after stimulation by 200 microg. TRH IV as a bolus (4 cases) was not significant. We have found similar prolactin variations in cases of hyperprolactinemia with either normal pituitary fossa (7 cases) or macro-adenoma (6 cases).
mesh_terms: D000236:Adenoma / Q000503:physiopathology*; D000328:Adult; D000568:Amenorrhea / Q000503:physiopathology*; D005260:Female; D005687:Galactorrhea / Q000503:physiopathology*; D006801:Humans; D007006:Hypogonadism / Q000503:physiopathology*; D007775:Lactation Disorders / Q000503:physiopathology*; D008297:Male; D010911:Pituitary Neoplasms / Q000503:physiopathology*; D011247:Pregnancy; D011388:Prolactin / Q000097:blood / Q000378:metabolism*; D012658:Sella Turcica
chemical_list: D011388:Prolactin
vernacular_title: Etude de la fonction prolactinique dans 14 cas de galactorrhée avec hypogonadisme et micro-déformation de la selle turcique