Pharmacokinetic analysis using an electrical analogue.
After i.v. administration, the distribution and elimination of many drugs may be simulated by a compartmental mathematical model. The analogue can be used to construct such models in electrical terms. When programmed with an appropriate model, the analogue can be used in a wide range of predictive studies. The application of the analogue is illustrated by analysis of serial plasma concentrations of fentanyl and pancuronium.
D005260:Female; D005283:Fentanyl / Q000097:blood / Q000378:metabolism; D006801:Humans; D007275:Injections, Intravenous; D007700:Kinetics; D008875:Middle Aged; D008954:Models, Biological; D010197:Pancuronium / Q000097:blood / Q000378:metabolism; D004364:Pharmaceutical Preparations / Q000378:metabolism*
D004364:Pharmaceutical Preparations; D010197:Pancuronium; D005283:Fentanyl