[Pharmacokinetics of P32-phosphemide in the body of rats with sarcoma 45].
Pharmacokinetics of phosphamide-32P was studied in experiments on rats with sarcoma 45 and intact (tumourless) ones. Soon (15 min to 1 hour) after intraperitoneal injection of the compound the maximum amount of the isotope was definable in the liver, kidneys, spleen, suprarenals, in the tumour and the thymus. The content of the compound in the tumour ammounted to 0.2--0.4 per cent of the radioactivity introduced. Distribution of phosphemide-32P among organs and tissues of the rats with sarcoma 45 quatitatively differs from that in intact animals. During the first 24 hours 55--56 per cent of the radioactivity introduced is excreted together with urine.
D000311:Adrenal Glands / Q000378:metabolism; D000818:Animals; D000970:Antineoplastic Agents / Q000008:administration & dosage / Q000378:metabolism*; D001389:Azirines / Q000378:metabolism*; D001682:Biological Availability; D007274:Injections, Intraperitoneal; D007413:Intestinal Mucosa / Q000378:metabolism; D007553:Isotope Labeling; D007668:Kidney / Q000378:metabolism; D008099:Liver / Q000378:metabolism; D008198:Lymph Nodes / Q000378:metabolism; D008297:Male; D009943:Organophosphorus Compounds; D010761:Phosphorus Radioisotopes; D051381:Rats; D012513:Sarcoma, Experimental / Q000378:metabolism*; D013154:Spleen / Q000378:metabolism; D013950:Thymus Gland / Q000378:metabolism; D013997:Time Factors
D000970:Antineoplastic Agents; D001389:Azirines; D009943:Organophosphorus Compounds; D010761:Phosphorus Radioisotopes
Farmakokinetika fosfemida-32P v organizme krys s sarkomoĭ 45.