[Lactate dehydrogenase isoenzymatic activity in different parts of the brain and in the blood serum of rats from different lines during a convulsive seizure caused by the action of a sound stimulus].
Total lactate dehydrogenase activity and relative activities of LDH-1 and LDH-2 isozymes were found to be distinctly elevated in the cortex of cerebral hemispheres (locomotory region) and in medulla oblongata of audiogenic rats KM strain. The increase in the total LDH activity was also observed in blood serum of rats KM strain. The increase in the total LDH activity and in LDH-4 and LDH-5 activities in the brain regions studied was shown in epileptoid convulsions of audiogenic origin. These alterations demonstrated the compensatory activation of glycolysis in the brain tissue.
D000161:Acoustic Stimulation; D000818:Animals; D001921:Brain / Q000201:enzymology*; D002540:Cerebral Cortex / Q000201:enzymology; D004789:Enzyme Activation; D006019:Glycolysis; D007527:Isoenzymes; D007770:L-Lactate Dehydrogenase / Q000378:metabolism*; D008297:Male; D008526:Medulla Oblongata / Q000201:enzymology; D051381:Rats; D011919:Rats, Inbred Strains; D012640:Seizures / Q000201:enzymology*
D007527:Isoenzymes; D007770:L-Lactate Dehydrogenase
Aktivnost' izofermentov laktatdegidrogenazy v razlichnykh otdelakh mozga i syvorotke krovi krys raznykh liniĭ vo vremia sudorozhnogo pripadka, vyzvannogo deĭstviem zvukovogo razdrazhitelia