[Study of the metanephros of fetuses, newborn and 2-month-old mice developing under conditions of kidney damage to the females by nephrocytotoxic serum].
In the metanephros of foetuses beginning from the 14 days of development and in the newborn mice from females with injured kidneys, marked defects of proximal convoluted tubules and less marked defects of glomeruli were noted what corresponded to the character of kidney injury in their mothers. At the same time the diameter of glomeruli and convoluted tubules, the height and width of their cells increased, but the diameter of their nuclei decreased. These changes are accompanied by distrophic changes, mainly in the cells of convoluted tubules, the most markedly expressed in the newborn mice. No marked histological changes were found in the metanephros of two months old experimental mice.
D000818:Animals; D000831:Animals, Newborn; D005260:Female; D007106:Immune Sera / Q000494:pharmacology*; D007668:Kidney / Q000196:embryology* / Q000254:growth & development / Q000276:immunology; D008431:Maternal-Fetal Exchange; D051379:Mice; D008808:Mice, Inbred CBA; D011247:Pregnancy; D011270:Pregnancy, Animal
D007106:Immune Sera
Izuchenie metanefrosa plodov, novorozhdennykh i dvukhmesiachnykh mysheĭ razvivavshikhsia v usloviiakh povrezhdeniia pochek samok nefrotsitotoksicheskoĭ syvorotkoĭ