[Cytological changes in the csf caused by inthathecal administration of methotrexate. II. Studies on a case of neuroblastoma with cerebellar symptoms in a child].
A case of an olfactory neuroblastoma of a 5 years old child is reported. The tumour propagated into the intracranial space and produced cerebellar symptoms. Features of the neuroblastic cells, found in the cerebrospinal fluid and their alterations as an effect of the intrathecal therapy with Mathotrexat are analysed. Authors emphasize the differences of alterations of leukaemic and neuroblastic cells called into being by the Methotrexat therapy.
D002524:Cerebellar Ataxia / Q000209:etiology*; D002555:Cerebrospinal Fluid / Q000187:drug effects*; D002675:Child, Preschool; D006801:Humans; D007278:Injections, Spinal; D008297:Male; D008443:Maxillary Sinus / Q000473:pathology; D008727:Methotrexate / Q000008:administration & dosage / Q000009:adverse effects*; D009362:Neoplasm Metastasis; D009447:Neuroblastoma / Q000134:cerebrospinal fluid* / Q000188:drug therapy / Q000473:pathology; D010255:Paranasal Sinus Neoplasms / Q000134:cerebrospinal fluid* / Q000473:pathology
D008727:Methotrexate
Liquorcytologiai elváltozások intrathecalis methotrexat kezelés hatására. II. Vizsgálatok kisagyi tünetekkel kísért gyermekkori neuroblastoma esetében