[Hematin treatment of porphyric neuropathy].
The authors report a case of acute intermittent porphiria with peripheral motor neuropathy and a syndrome of inadequate ADH excretion in a male patient aged 36 years. Treatment with hypertonic glucose and prostigmine did not yield any beneficial results, while a subsequent treatment with hematine (4 mg/kg/day for a period of four days) produced a dramatic improvement in the clinical picture and in ALA and PGB levels. A back-to-normal shift of plasma and urinary electrolytes was also observed. It appears that there was a close relation between the administration of hematine and the clinical-biochemical remission.
D000328:Adult; D004341:Drug Evaluation; D006418:Heme / Q000031:analogs & derivatives*; D006427:Hemin / Q000627:therapeutic use*; D006801:Humans; D007275:Injections, Intravenous; D008297:Male; D011164:Porphyrias / Q000150:complications / Q000188:drug therapy*; D011782:Quadriplegia / Q000188:drug therapy* / Q000209:etiology
D006418:Heme; D006427:Hemin
Tratamiento con hematina de la neuropatía porfírca