Binding of inorganic mercury by subcellllar fractions and proteins of rat kidneys.
Inorganic mercury, administered to rats in a single dose of 0.5 mg Hg/kg is accumulated in the kidneys mainly in the soluble (54%) and nuclear (30%) fractions, showing decreasing tendency with time. Mitochondrial and microsomal fractions, initially accumulating approx. 11 and 6% of total Hg, show a tendency to increase the absolute level of Hg for the first week after administration. In the soluble fraction low-molecular weight, metallothioneinlike proteins are mainly responsible for the accumulation of mercury, in other fractions proteins of higher molecular weight prevail.
D000818:Animals; D005260:Female; D007668:Kidney / Q000378:metabolism* / Q000648:ultrastructure; D008628:Mercury / Q000378:metabolism*; D008970:Molecular Weight; D009698:Nucleoproteins / Q000378:metabolism; D011485:Protein Binding; D051381:Rats; D013347:Subcellular Fractions / Q000378:metabolism
D009698:Nucleoproteins; D008628:Mercury