[Content of polyribosomes and poly-A-containing RNA in rat liver during hepatocarcinogenesis induced by diethylnitrosamine].
The contents of total polyribosomes and the ratio of free to membrano-bound polyribosomes as well as the number of poly(A)-containing RNA in cytoplasm and in two classes of polyribosomes of the liver were studied in rats chronically treated with diethylnitrosamine. A decrease in the number of total polyribosomes and changes in the ratio of free to membrane-bound polyribosomes toward a decrease of the latter were found within the whole period of carcinogenesis. The absolute amount of the free polyribosomes per 1 gr of the liver tissue did not differ significantly from the normal values but the number of the membrane-bound polyribosomes in the treated animals was 2-2,5 times as low. The amount of poly(A)-containing RNA in the postmitochondrial fraction increased and decreased in free polyribosomes. A redistribution of the templates by free and membrane-bound polyribosomes in cytoplasm of the hepatocytes during hepatocarcinogenesis due to the disturbances in the equilibrium between these two classes of polyribosomes is suggested.
D000818:Animals; D055598:Chemical Phenomena; D002621:Chemistry; D004052:Diethylnitrosamine; D008113:Liver Neoplasms / Q000139:chemically induced / Q000378:metabolism / Q000648:ultrastructure*; D008297:Male; D011061:Poly A; D011132:Polyribosomes / Q000648:ultrastructure*; D012334:RNA, Neoplasm / Q000378:metabolism*; D051381:Rats
D012334:RNA, Neoplasm; D011061:Poly A; D004052:Diethylnitrosamine
Vmist polirybosom i poli-A-vmisnoï RNK v pechintsi shchuriv u dynamitsi hepatokantserohenezu, indukovanoho dietylnitrozaminom