[Effect of subacute fluorine poisoning in the rabbit on fluorine and phosphorus-calcium metabolism and on radiography of the skeleton].
Rabbit subacute fluoride intoxication effects (21,4 mg a day for 10 months) are researched on fluor, calcium and phosphorus metabolism and on skeletal radiology. Fluoremy increase (p less than 0.05) and there is a strong fluor retention (p less than 0.01), due to fluor digestive utilization coefficient increase (p less than 0.05), in spite of relative hyperfluorury (p less than 0.05). Calcemy decreases (p less than 0.01), but phosphatemy and alkaline phosphatasemy do not vary but a little. Calcium and phosphorus balances become negative (p less than 0.05), due to calcium digestive utilization coefficient inversion (p less than 0.05) and phosphorus digestive utilization coefficient decrease (p less than 0.05) and hypercalciury (p less than 0.05) and hyperphosphatury (p less than 0.05) with phosphorus renal reabsorption coefficient decrease (p less than 0.05). Some skeletal radiological abnormalities appear on rachis and limbs.
D000469:Alkaline Phosphatase / Q000097:blood; D000818:Animals; D001842:Bone and Bones / Q000000981:diagnostic imaging* / Q000187:drug effects; D002118:Calcium / Q000378:metabolism*; D005260:Female; D005461:Fluorine / Q000378:metabolism / Q000506:poisoning*; D007668:Kidney / Q000378:metabolism; D008297:Male; D010758:Phosphorus / Q000378:metabolism*; D011817:Rabbits; D011859:Radiography; D013997:Time Factors
D010758:Phosphorus; D005461:Fluorine; D000469:Alkaline Phosphatase; D002118:Calcium
Effets de l'intoxication fluorée subaiguë du lapin sur les métabolismes fluoré et phosphocalcique et sur la radiographie du squelette.