Indocyanine green plasma clearance in normal human males and females.
The plasma clearance of indocyanine green (Cardio-Green, 0.5 mg/kg body weight) was studied in a total of 352 plasma samples from 7 male and 8 female healthy volunteers, and total bilirubinaemia in 6 males and 6 females. Statistical analysis (linear regression, SAAM programmes by BERMAN and WEISS [2],t-test. F-test and rank correlation) disclosed a significantly higher plasma disappearance rate of indocyanine green and significantly lower total bilirubinaemia in females than in males with a statistically almost significant negative correlation of both phenomena. A better excretion of indocyanine green from liver to bile in males though statistically significant could be an artefact caused e.g. by a not quite significant abnormally of the calibration straight line of the dye.
D000328:Adult; D001663:Bilirubin / Q000097:blood; D001835:Body Weight; D005260:Female; D006801:Humans; D007208:Indocyanine Green / Q000097:blood* / Q000378:metabolism; D008099:Liver / Q000378:metabolism; D008297:Male; D012737:Sex Factors
D007208:Indocyanine Green; D001663:Bilirubin