[Determination of embryotoxic and teratogenic effect of a new antidepressive agent, pyrazidol].
The effect of the new original antidepressant pyrasidol on the embryogenesis of albino rats was investigated. With a single introduction of the drug with a tube into the stomach in a dose of 200 mg/kg within the first 15 days of pregnancy pyradisol was found to produce no embrytoxic and teratogenic effects. Fluorescent microscopy revealed the presence of the pyrasidol metabolites in the amniotic fluid of the test animals 2 hours after enteral administration of the drug, on the 15th and 20th days of pregnancy.
D000653:Amniotic Fluid / Q000032:analysis / Q000378:metabolism; D000818:Animals; D000928:Antidepressive Agents / Q000378:metabolism / Q000633:toxicity*; D004341:Drug Evaluation; D004622:Embryo, Mammalian / Q000187:drug effects*; D005260:Female; D007211:Indoles / Q000378:metabolism / Q000633:toxicity*; D008856:Microscopy, Fluorescence; D011247:Pregnancy; D011719:Pyrazines / Q000378:metabolism / Q000633:toxicity*; D051381:Rats; D013723:Teratogens / Q000633:toxicity
D000928:Antidepressive Agents; D007211:Indoles; D011719:Pyrazines; D013723:Teratogens
Opredelenie embriotoksicheskogo i teratogennogo deĭstviia novogo antidepressanta pirazidola.