[Development of alloxan diabetes and its effect on the sexual system of male rats under conditions of alpha adrenergic receptor blockaders].
A study was made of the influence of the block of the alpha-adrenoreceptors in male rats on the development of alloxan diabetes and on such its complication as depression of the sexual system function. Phetholamine sharply decreased the death of the animals the first 3--4 days after the alloxan administration: only 5.3% of the animals died. As to rats with intact alpha-adrenoreceptors--42% of the died. Block of the alpha-adrenoreceptors decreased the percentage of rats with marked diabetes. In 37.2% of rats given alloxan and phentholamine diabetes was very mild or failed to develop entirely. Phentholamine significantly lowered the depressive effect of alloxan diabetes on the sexual system considerably.
D000818:Animals; D003864:Depression, Chemical; D003921:Diabetes Mellitus, Experimental / Q000503:physiopathology; D004336:Drug Antagonism; D005837:Genitalia, Male / Q000187:drug effects*; D008297:Male; D009929:Organ Size / Q000187:drug effects; D010646:Phentolamine / Q000494:pharmacology*; D011467:Prostate / Q000187:drug effects; D051381:Rats; D012669:Seminal Vesicles / Q000187:drug effects; D013737:Testis / Q000187:drug effects
D010646:Phentolamine
Razvitie alloksanovogo diabeta i ego vliianie na polobuiu sistemu krys-samtsov v usloviiakh blakady alpha-adrenoretseptorov.