Radiation sensitizing effect of diamide on human cells cultivated in vitro.
Human cells of line NHIK 3025 were irradiated suspended in growth medium (E2a) in absence and presence of diamide under aerobic and extremely hypoxic (less than 4 ppm O2) conditions. A sensitizing effect of diamide was found for doses exceeding 8 Gy (800 rad) on cells irradiated under extremely hypoxic conditions in presence of diamide of concentration 200 micrometer, whereas no significant effect was observed for 20 micrometer.
D001391:Azo Compounds / Q000494:pharmacology*; D002455:Cell Division / Q000528:radiation effects*; D002460:Cell Line; D002470:Cell Survival / Q000528:radiation effects*; D003470:Culture Media; D003958:Diamide / Q000494:pharmacology*; D004307:Dose-Response Relationship, Radiation; D005947:Glucose / Q000378:metabolism; D006801:Humans; D000860:Hypoxia; D066298:In Vitro Techniques; D011836:Radiation Tolerance
D001391:Azo Compounds; D003470:Culture Media; D003958:Diamide; D005947:Glucose