Aryl-hydrocarbon hydroxylase activity in lymphocytes from lung cancer patients and normal controls.
A radiometric assay for the determination of AHH activity in lymphocytes is described. Subjects included eleven male patients with histologically verified lung cancer (nine squamous cell carcinoma and two adenocarcinoma) and eleven age- and sex-matched controls. Lung cancer patients exhibited considerably greater variation and elevated levels of both AHH activity per se and AHH activity adjusted for total cellular DNA than control individuals. Methodology for AHH determinations and implications for lung cancer epidemiology and control are discussed.
D000230:Adenocarcinoma / Q000097:blood / Q000201:enzymology*; D000328:Adult; D000368:Aged; D001189:Aryl Hydrocarbon Hydroxylases / Q000378:metabolism*; D002294:Carcinoma, Squamous Cell / Q000097:blood / Q000201:enzymology*; D004247:DNA / Q000032:analysis; D004273:DNA, Neoplasm / Q000032:analysis; D004790:Enzyme Induction; D006801:Humans; D008175:Lung Neoplasms / Q000097:blood / Q000201:enzymology*; D008214:Lymphocytes / Q000032:analysis / Q000201:enzymology*; D008297:Male; D008875:Middle Aged
D004273:DNA, Neoplasm; D004247:DNA; D001189:Aryl Hydrocarbon Hydroxylases