Platelet-aggregating activity of type I and type III collagens from human aorta and chicken skin.
Human or chicken type III collagen dissolved in 0.1 M-acetic acid was much more potent than type I collagen at inducing platelet aggregation. After incubation in 0.38M-Na2HPO4 to promote fibrillogenesis, the platelet-aggregating activity of both collagen types increased, and type I was then virtually equiactive with type III. Preincubation in cell-free plasma increased the activity of chicken but not that of human collagen. The platelet-aggregating activity of type III collagen did not appear to depend on the integrity of the intrachain disulphide bonds.
D000328:Adult; D000368:Aged; D000818:Animals; D001011:Aorta / Q000032:analysis; D002645:Chickens; D003094:Collagen / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D006801:Humans; D008875:Middle Aged; D010974:Platelet Aggregation / Q000187:drug effects*; D011487:Protein Conformation; D012867:Skin / Q000032:analysis; D013268:Stimulation, Chemical
D003094:Collagen