Potentiation by taurine of the inotropic effect of ouabain and the content of intracellular Ca++ and taurine in the heart.
Under certain conditions, taurine (3.0mM) potentiated cardiac contractile response to ouabain in the normal medium. The potentiation by taurine was also observed in the low K+ medium, in which the positive inotropic effect of ouabain increased. The potentiation as seen in both media was, at least in part, due to the increase by taurine of Ca++ content in the heart. Taurine in the heart was not directly related to this potentiation.
D000818:Animals; D002118:Calcium / Q000378:metabolism; D004357:Drug Synergism; D006168:Guinea Pigs; D006321:Heart / Q000187:drug effects* / Q000502:physiology; D008297:Male; D009200:Myocardial Contraction / Q000187:drug effects; D009206:Myocardium / Q000378:metabolism; D010042:Ouabain / Q000494:pharmacology*; D011188:Potassium / Q000494:pharmacology; D013654:Taurine / Q000378:metabolism / Q000494:pharmacology*
D013654:Taurine; D010042:Ouabain; D011188:Potassium; D002118:Calcium