[Reactivation of phosphorylated acetylcholinesterase (AChE): quaternary salts of vinylogous pyridinaldoxims (author's transl)].
Application of Wittig reaction to 4-pyridinecarboxaldehyde leads to 4-beta-formylvinylpyridine (62%). The corresponding oxime (4-(2)) can be quaternized with alpha,alpha'-bis-(chloromegonin), and with methyliodide one to 4-PAM (4-(3)). In this case the formal insertion of an ethylenic double bond between the pyridinium ring and the aldoxime group decreases the ability to reactivate phosphorylated acetylcholinesterase (AChE).
D000110:Acetylcholinesterase; D002801:Cholinesterase Reactivators / Q000138:chemical synthesis*; D011220:Pralidoxime Compounds / Q000138:chemical synthesis*; D013329:Structure-Activity Relationship; D014753:Vinyl Compounds / Q000138:chemical synthesis
D002801:Cholinesterase Reactivators; D011220:Pralidoxime Compounds; D014753:Vinyl Compounds; D000110:Acetylcholinesterase
Reaktivierung phosphorylierter Acetylcholinesterase (AChE): Quartäre Salze vinyloger Pyridinaldoxime