[Effect of aeration conditions on the biosynthesis of carminomycin by an actinomadura carminata culture].
The effect of the aeration rate on biosynthesis of carminomycin by Actinomadura carminata and biochemical changes in the fermentation broth on the use of 3 complex media of different composition was studied. The carminomycin-producing organism can grow and produce the antibiotic within the ranges of the aeration changes from 0.98 to 18.56 mgO2/1-min. A decrease in the maximum rate of oxygen dissolution up to 0.98 mgO2/1-min resulted in some decrease in the activity level. Intensive aeration, i.e. 18.56 mgO2/1-min induced suppression of the antibiotic production by 25 per cent.
D000332:Aerobiosis; D000903:Antibiotics, Antineoplastic / Q000096:biosynthesis*; D002360:Carubicin / Q000032:analysis / Q000096:biosynthesis*; D003470:Culture Media / Q000378:metabolism*; D009615:Nocardia / Q000378:metabolism*; D013997:Time Factors
D000903:Antibiotics, Antineoplastic; D003470:Culture Media; D002360:Carubicin
Vliianie usloviĭ aératsii na biosintez karminomitsina kul'turoĭ Actinomadura carminata