[Stimulating effect of histones on DNA synthesis in the regenerating rat liver].
Effect of exogenous histones, nuclear globulins and acid proteins on DNA synthesis is studied in regenerating liver of rats in which the synthesis of their own proteins and thus DNA replication are inhibited by cycloheximide. In these conditions histones from regenerating rat liver are found to stimulate 3H-thymidine incorporation into DNA of hepatectomyzed rat liver. Nuclear globulins and acid proteins from regenerating liver, and histones from intact liver produced no stimulating effect on DNA sythesis.
D000818:Animals; D003513:Cycloheximide / Q000494:pharmacology; D004247:DNA / Q000096:biosynthesis*; D004261:DNA Replication / Q000187:drug effects; D005916:Globulins / Q000494:pharmacology; D006498:Hepatectomy; D006657:Histones / Q000008:administration & dosage / Q000494:pharmacology*; D007553:Isotope Labeling; D008099:Liver / Q000378:metabolism*; D008115:Liver Regeneration; D008239:Lysine; D008297:Male; D009698:Nucleoproteins / Q000494:pharmacology*; D051381:Rats; D014316:Tritium
D005916:Globulins; D006657:Histones; D009698:Nucleoproteins; D014316:Tritium; D004247:DNA; D003513:Cycloheximide; D008239:Lysine
Stimuliruiushchee deĭstvie gistonov na sistez DNK v regeneriruiushcheĭ pecheni krys.