[Neurochemical aspects of corrective effect of fluoracizine in triphthazine-induced catalepsy in rats].
Following introduction of triftazine (2 mg/kg) and phthoracizine 8 mg/kg, separately and in combination, the intensity of catalepsy, the content of dopamine, norepinephrine (fluorometrically), of acetylcholine (biologically) and the activity of cholinesterase (calorimetrically) in the caudate nuclei and the frontal part of the cortex were determined in rats. It was established that with its one-time administration phthoracizine, while keeping down the intensity of triftazine-induced catalepsy, prevents, at the same time, the development of a number of biochemical effects, viz. there appears a distinctly pronounced tendency toward mormalization of the dopamine, acetylcholine levels and of the cholinesterase activity. A multiple joint administration of the drugs is also attended by lowering the intensity of catalepsy. Then, biochemical changes manifest themselves in more complex interrelations.
D000109:Acetylcholine / Q000378:metabolism; D000818:Animals; D002375:Catalepsy / Q000139:chemically induced / Q000188:drug therapy* / Q000378:metabolism; D002421:Caudate Nucleus / Q000187:drug effects / Q000378:metabolism; D002802:Cholinesterases / Q000378:metabolism; D004298:Dopamine / Q000378:metabolism; D004336:Drug Antagonism; D006801:Humans; D008297:Male; D009638:Norepinephrine / Q000378:metabolism; D010276:Parasympatholytics / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*; D010640:Phenothiazines / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*; D051381:Rats; D014268:Trifluoperazine
D010276:Parasympatholytics; D010640:Phenothiazines; D014268:Trifluoperazine; C001228:fluoracizine; D002802:Cholinesterases; D000109:Acetylcholine; D004298:Dopamine; D009638:Norepinephrine
Neĭrokhimicheskie aspekty korrektornogo deĭstviia ftoratsizina pri triftazinovoĭ katalepsii u krys.