Common metabolites of N-nitroso-2,6-dimethylomorpholine and N-nitroso-bis(2-oxopropyl)amine in the Syrian hamster.
N-Nitroso-2,6-demethylmorpholine (NDMM) administered intraperitoneally to Syrian hamsters was metabolized  to N-nitroso-bis(2-hydroxypropy)(2-oxopropyl)amine(HPOP) and N-nitroso-bis(2-hydroxpropyl)amine (BHP) which were identified in blood and urine. The potent pancreatic carcinogen N-nitroso-bis(2-oxoproply)amine was previously shown to form the same metabolites. Preliminary results indicate that NDMM also induces pancreatic and other tumors in Syrian hamsters, similar to those found following BHP treatment.
D000368:Aged; D000818:Animals; D006224:Cricetinae; D006801:Humans; D008297:Male; D008647:Mesocricetus; D009025:Morpholines / Q000378:metabolism* / Q000633:toxicity; D009374:Neoplasms, Experimental / Q000139:chemically induced; D009602:Nitrosamines / Q000378:metabolism* / Q000633:toxicity; D010190:Pancreatic Neoplasms / Q000139:chemically induced
D009025:Morpholines; D009602:Nitrosamines