Diuretic action of estradiol.
Several clinical situations are strongly suggestive that estrogens are diuretic substances that secondarily promote sodium and water retention in the body by stimulation of adreno-cortical hormone secretion. To investigate the direct action of estradiol on diuresis, the hormone was administered to the isolated, perfused rabbit kidney. Results demonstrated that estradiol increases urine volume, tubular sodium excretion and potassium reabsorption, and diminishes arterial pressure and renovascular resistance. The possible relationships between these effects and with pre-menstrual syndrome, pre-eclampsia, and menopausal hypertension are discussed.
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D003404:Creatinine / Q000378:metabolism; D004232:Diuretics; D004958:Estradiol / Q000494:pharmacology*; D066298:In Vitro Techniques; D007668:Kidney / Q000187:drug effects / Q000502:physiology*; D011188:Potassium / Q000378:metabolism; D011817:Rabbits; D012964:Sodium / Q000378:metabolism; D014556:Urine; D014655:Vascular Resistance / Q000187:drug effects
D004232:Diuretics; D004958:Estradiol; D012964:Sodium; D003404:Creatinine; D011188:Potassium