title: [Rubella vaccination with "Cendehill" and "RA 27/3". Reinfection of vaccinated and naturally immune persons compared with the infection rate of susceptible persons within a 3-resp. 5-year observation period (author's transl)].
abstract: Many investigators in Europe and the USA have usually found high rates of serum conversion after vaccination with the rubella vaccines Cendehill and RA 27/3, but the resistance of vaccinated individuals against superinfection without disease induced by wild virus strains under experimental or natural conditions seems to be very low; e.g. up to 80% of the vaccinees reacted with increasing titers of hemagglutination inhibiting antibodies after super-infection with a wild virus in a special epidemiological situation. In our two studies performed under natural conditions of infection including an observation period of three years resp. five years after vaccination a more favourable picture evolved, perhaps reflecting a different epidemiological situation, a different susceptibility or a less virulence of wild virus in our region: Three years after vaccination of 14 years old girls with Cendehill and RA 27/3 in a double blind trial a significant increase in the titers of hemagglutination inhibiting antibodies was observed after vaccination with Cendehill by the subcutaneous route in only 1,16% (1/86) and in 1,18% (1/85) after vaccination with RA 27/3 by the same route. In the same observation period the infection rate in a control group not protected by natural immunity or by vaccination was 54,72% (87/159) and in a second control group, protected by natural immunity 1,82% (3/165)...
mesh_terms: D000293:Adolescent; D005260:Female; D005500:Follow-Up Studies; D006385:Hemagglutination Inhibition Tests; D006801:Humans; D012409:Rubella / Q000276:immunology / Q000517:prevention & control*; D012411:Rubella Vaccine / Q000009:adverse effects*; D014613:Vaccines, Attenuated / Q000009:adverse effects
chemical_list: D012411:Rubella Vaccine; D014613:Vaccines, Attenuated
vernacular_title: Feldversuch zur Wertbemessung von Rötelnimpfstoffen. Röteln-Impfung mit "Cendehill" und "RA 27/3", die. Reinfektionshäufigkeit der geimpften und natürlich immunen Personen im Vergleich mit der Infektionshäufigkeit empfänglicher personen innerhalb einer 3- bzw. 5jährigen Beobachtungszeit