Choroid plexus papilloma. I. Proof of cerebrospinal fluid overproduction.
Utilizing a ventricular perfusion technique, the rate of CSF formation was determined in a 2-year-old child before and after removal of a 74 g choroid plexus papilloma from the left lateral ventricle. Preoperatively, the CSF formation rate was 1.05 +/- SD 0.01 ml/min (1,656 ml/day). Postoperatively, the CSF formation rate was reduced fivefold to 0.20 +/- SD 0.01 ml/min (288 ml/day). Whereas these data are regarded as conclusive evidence of CSF overproduction by a choroid plexus papilloma, the pathogenesis of generalized ventricular enlargement in this case was due to part to obstruction of the subarachnoid pathways.
D002551:Cerebral Ventricle Neoplasms / Q000134:cerebrospinal fluid* / Q000150:complications / Q000378:metabolism / Q000601:surgery; D002555:Cerebrospinal Fluid / Q000378:metabolism*; D002831:Choroid Plexus; D006801:Humans; D006849:Hydrocephalus / Q000209:etiology*; D007223:Infant; D007427:Intracranial Pressure; D008297:Male; D010212:Papilloma / Q000134:cerebrospinal fluid* / Q000150:complications / Q000378:metabolism / Q000601:surgery