Enhancement of tumour growth by pretreatment with tumoral cells adsorbed by poly i:c deae-dextran complex in syngeneic mice.
Pretreatment of balb/c mice with ADK-1t cells adsorbed with Poly I:C DEAE- dx complex was found to enhance tumour growth as measured after challenge with non adsorbed ADK-1t cells. This results contrasts strongly with the increased tumour resistance previously observed when Poly I:C alone was used for adsorption. Some reasons are suggested for this striking difference.
D000818:Animals; D000917:Antibody Formation / Q000187:drug effects; D002462:Cell Membrane / Q000276:immunology; D003637:DEAE-Dextran / Q000494:pharmacology*; D003911:Dextrans / Q000031:analogs & derivatives*; D051379:Mice; D008807:Mice, Inbred BALB C; D009374:Neoplasms, Experimental / Q000276:immunology*; D011070:Poly I-C / Q000494:pharmacology*
D003911:Dextrans; D003637:DEAE-Dextran; D011070:Poly I-C