Antimycotic activity in vitro and in vivo of a new hydrosoluble polyene antibiotic.
The in vitro and in vivo activity of a new water soluble polyene antibiotic, anmed SPA-S-222, has been studied on numerous Candida and Cryptococcus species. The in vitro tests were carried out in comparison with nystatin and amphotericin B whose antimycotic properties are already well known. The inhibition of "germination" of various strains of Candida albicans was also investigated. The results show that SPA-S-222 has greater antimycotic activity than nystatin or amphotericin B. Tests on the protection afforded by SPA-S-222 in Swiss albino mice infected with C, albicans were satisfactory as regards both the total protective dose and the partial protective dose (P.D. 50%).
D000666:Amphotericin B / Q000494:pharmacology; D000818:Animals; D000935:Antifungal Agents / Q000494:pharmacology*; D002175:Candida / Q000187:drug effects; D003454:Cryptococcus / Q000187:drug effects; D066298:In Vitro Techniques; D051379:Mice; D009761:Nystatin / Q000494:pharmacology; D011090:Polyenes / Q000494:pharmacology*; D012995:Solubility
D000935:Antifungal Agents; D011090:Polyenes; D009761:Nystatin; D000666:Amphotericin B