Mechanism of action of methotrexate. IV. Free intracellular methotrexate required to suppress dihydrofolate reduction to tetrahydrofolate by Ehrlich ascites tumor cells in vitro.
D000818:Animals; D002286:Carcinoma, Ehrlich Tumor / Q000201:enzymology*; D002478:Cells, Cultured; D005492:Folic Acid / Q000378:metabolism; D005493:Folic Acid Antagonists; D008727:Methotrexate / Q000494:pharmacology*; D051379:Mice
D005493:Folic Acid Antagonists; D005492:Folic Acid; D008727:Methotrexate