The role of renin in the control of blood pressure in normotensive man.
In order to study the  role of renin in regulating blood pressure in normotensive states, saralasin (P113) was infused into normal subjects and patients with cirrhosis of the liver and ascites. In normal subjects on a normal sodium intake, P113 infusion had no effect on blood pressure. Only after the combined stress of a low sodium diet and the upright position did P113 lower the blood pressure. In two of the six cirrhotic patients, P113 caused a significant decrease in BP in the supine position. There was no consistent effect of the P113 infusion on plasma aldosterone or plasma renin activity in the normal or cirrhotic subjects.
D000450:Aldosterone / Q000097:blood; D001794:Blood Pressure / Q000187:drug effects; D004032:Diet; D006801:Humans; D008103:Liver Cirrhosis / Q000503:physiopathology; D011187:Posture; D011674:Pulse / Q000187:drug effects; D012083:Renin / Q000097:blood / Q000502:physiology*; D012504:Saralasin / Q000494:pharmacology; D012964:Sodium / Q000494:pharmacology; D013997:Time Factors
D000450:Aldosterone; D012964:Sodium; D012083:Renin; D012504:Saralasin