title: [Rifadin activity in trachoma and paratrachoma].
abstract: Rifadin after a single inoculation in a dose of 100 microng/ml completely inhibited the development of the causative agent of trachoma in cell culture. In patients with trachoma (18) and paratrachoma (4) cure was achieved by topical application of 5% ointment. Additional administration of the drug per os did not produce any considerable improvement. The cure was confirmed by the results of clinical, biomicroscopic, cytological and histological examinations of the tarsoconjunctival tissue (biopsy according to indications). Repeated examinations of the patients were carried out for 4 years and no cases of relapse were observed.
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D002648:Child; D002675:Child, Preschool; D003235:Conjunctivitis, Inclusion / Q000188:drug therapy*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D012294:Rifamycins / Q000627:therapeutic use*; D014141:Trachoma / Q000188:drug therapy*
chemical_list: D012294:Rifamycins
vernacular_title: Aktivnost' rifadina pri trakhome i paratrakhome