The effect of diftalone on collagen and glycosaminoglycans metabolism.
Diftalone showed a distinct inhibition effect on the collagen formation in sponge granuloma as well as in chick embryos articular cartilage. The inhibitory effect was expressed even in corneal and articular cartilage glycosaminoglycans (GAG) sulphation and GAG formation in granulation tissue. According to our previous results diftalone showed a similar inhibition of collagen and GAG biosynthesis as other effective antirheumatic drugs.
D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology*; D002358:Cartilage, Articular / Q000378:metabolism*; D002642:Chick Embryo; D003094:Collagen / Q000096:biosynthesis*; D003864:Depression, Chemical; D004305:Dose-Response Relationship, Drug; D006025:Glycosaminoglycans / Q000096:biosynthesis*; D010793:Phthalazines / Q000008:administration & dosage / Q000494:pharmacology*; D011724:Pyridazines / Q000494:pharmacology*; D051381:Rats
D000893:Anti-Inflammatory Agents; D006025:Glycosaminoglycans; D010793:Phthalazines; D011724:Pyridazines; D003094:Collagen