Anti-hypertensive action, time of onset and effects on carbohydrate metabolism of labetalol.
1 Seventeen men, aged 45-57 yr, with essential hypertension showed obvious and, in the standing position, dose-related reductions in blood pressure during treatment with oral labetalol with weekly dose increments. 2 Pulse rate changes were not related to dose but reduced compared with pre-treatment values. 3 No postural hypotension was recorded indicating lack of a dominant alpha-adrenoreceptor-blocking component. 4 There was a small increase in mean fasting blood glucose levels during labetalol treatment but no alteration in insulin activity or response to an oral glucose tolerance test.
D000818:Animals; D000959:Antihypertensive Agents; D001786:Blood Glucose / Q000378:metabolism; D001794:Blood Pressure / Q000187:drug effects; D050260:Carbohydrate Metabolism; D004305:Dose-Response Relationship, Drug; D004341:Drug Evaluation; D004983:Ethanolamines / Q000494:pharmacology*; D005951:Glucose Tolerance Test; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D006973:Hypertension / Q000503:physiopathology; D007328:Insulin / Q000097:blood; D007741:Labetalol / Q000009:adverse effects / Q000494:pharmacology* / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged; D013997:Time Factors
D000959:Antihypertensive Agents; D001786:Blood Glucose; D004983:Ethanolamines; D007328:Insulin; D007741:Labetalol