[Effect of colchicine and lumicolchicine on the ultrastructure of non-myelinated axons in autonomic nerves in cat in vitro].
The effects of colchicine and lumicolchicine on the ultrastructure of non-myelinated axons in cat autonomic nerves were studied using in vitro preparations of inferior mesenteric ganglion/hypogastric nerves. After 24 hrs of in vitro incubation with colchicine added to the medium (10 microng/ml) a significant decrease in number of neurotubules per 1 axon was observed. In the presence of a solution of alpha-beta and gamma-lumicolchicine (10 microng/ml) severe degenerative changes occured in axons and Schwann cells. At a lower dose of lumicolchicine (3 microng/ml) these changes were less frequent and the number of neurotubules per 1 axon did not differ from that in control nerves.
D000818:Animals; D001369:Axons / Q000187:drug effects / Q000648:ultrastructure*; D002415:Cats; D003078:Colchicine / Q000031:analogs & derivatives* / Q000494:pharmacology*; D005260:Female; D007001:Hypogastric Plexus / Q000187:drug effects / Q000648:ultrastructure*; D066298:In Vitro Techniques; D008297:Male; D012583:Schwann Cells / Q000187:drug effects / Q000648:ultrastructure
D003078:Colchicine
Die Wirkung des Kolchicins und Lumikolchicins auf die Feinstruktur markloser Axone in autonomen Nerven der Katze in vitro