Role of radioautographic studies in clinical investigative oncology and chemotherapy.
Three clinical areas are identified in which radioautographic studies may be of practical usefulness. First, human tumors can be classified according to the predominant pattern of DNA synthesis in the slowly proliferating cell fraction. This classification scheme groups carcinoma of the breast and ovary together, melanoma and carcinoma of the lung together, and places acute adult leukemia in a separate class. If there are correlations between kinetic characteristics and drug response behavior, this classification scheme may simplify the clinical study of new drugs and drug combinations. Second, changes in the labeling index (LI) and/or cell labeling intensity may serve as useful guides in drug scheduling. There are circumstances where changes in cell labeling intensity may be more reliable than changes in the LI. Third, cell morphology, population kinetics, and clinical course may all be correlated in certain human tumors, particularly the lymphomas. Supporting evidence in Sézary's syndrome is presented.
D000208:Acute Disease; D000328:Adult; D001345:Autoradiography; D001943:Breast Neoplasms / Q000188:drug therapy / Q000378:metabolism; D002455:Cell Division; D004273:DNA, Neoplasm / Q000096:biosynthesis; D005260:Female; D006801:Humans; D066298:In Vitro Techniques; D007700:Kinetics; D007938:Leukemia / Q000188:drug therapy / Q000378:metabolism / Q000473:pathology; D008214:Lymphocytes / Q000473:pathology; D008545:Melanoma / Q000188:drug therapy / Q000378:metabolism / Q000473:pathology; D008938:Mitosis; D009369:Neoplasms / Q000188:drug therapy*; D010051:Ovarian Neoplasms / Q000188:drug therapy; D012871:Skin Diseases / Q000473:pathology; D013997:Time Factors
D004273:DNA, Neoplasm