[Therapeutic modification of blood circulation disorders of the intestine due to strophantin].
The vasoconstrictor effects of strophanthin on mesenteric hemodynamics were studied using mechanical ventricular massage to exclude the cardiac effects of the drug. The administration of a calcium antagonistic compound prior to digitalis, together with and after digitalis application, prevented the vasoconstrictor response completely. From our experimental experience the combination of cardiac glycosides with calcium antagonistic compounds seems rational.
D000818:Animals; D002118:Calcium / Q000037:antagonists & inhibitors; D002496:Central Venous Pressure / Q000187:drug effects; D003251:Constriction, Pathologic / Q000139:chemically induced; D004285:Dogs; D007422:Intestines / Q000098:blood supply* / Q000503:physiopathology; D012039:Regional Blood Flow / Q000187:drug effects; D013328:Strophanthins / Q000009:adverse effects*; D014652:Vascular Diseases / Q000139:chemically induced
D013328:Strophanthins; D002118:Calcium
Therapeutische Beeinflussung strophanthinbedingter Durchblutungsstörungen des Darmes.