[Effect of exogenous DNA on the content and biosynthesis of endogenous DNA in rat bone marrow].
The influence of exogenous DNA on the content of endogenous DNA and the rate of biosynthesis was studied in rat bone marrow. After the injection of highly-polymerized homologous DNA to intact rats the content of rat DNA per 1 gm of the bone marrow decreased within the first 3 days (the most marked fall occurred in 3 days--by 36%), and returned to the normal by the 6th day. The rate of DNA biosynthesis in rat bone marrow increased in 18 hours (doublled in comparison with control), remained elevated within 6 days (by 58%) and approached the normal level from 1 to 3 days after the DNA injection.
D000818:Animals; D001853:Bone Marrow / Q000187:drug effects* / Q000378:metabolism; D004247:DNA / Q000096:biosynthesis / Q000378:metabolism* / Q000494:pharmacology*; D008297:Male; D051381:Rats; D013936:Thymidine / Q000378:metabolism; D013997:Time Factors; D014316:Tritium
D014316:Tritium; D004247:DNA; D013936:Thymidine
Vliianie ékzogennoĭ DNK na soderzhanie i biosintez éndogennoĭ DNK v kostnom mozge krys