High-pressure liquid chromatographic determination of chlorphenesin carbamate and the beta-isomeric carbamate.
A high-pressure liquid chromatographic assay was developed for the determination of chlorphenesin carbamate and its beta-isomeric carbamate. A single 4-mm i.d. X 30-cm column, prepacked with 10 micrometer fully porous silica gel particles, is used with 3% methanol in 50% water-saturated butyl chloride as the mobile phase. The procedure separates chlorphenesin carbamate from several possible impurities in addition to the beta-isomeric carbamate. The assay was applied to bulk drug and compressed tablets. The relative standard deviations for the assays of chlorphenesin carbamate and the beta-isomer are approximately 1 and 2%, respectively.
D002219:Carbamates / Q000032:analysis; D002743:Chlorphenesin / Q000032:analysis*; D002851:Chromatography, High Pressure Liquid; D004340:Drug Contamination; D007536:Isomerism; D008722:Methods; D013607:Tablets / Q000032:analysis
D002219:Carbamates; D013607:Tablets; D002743:Chlorphenesin