title: Mouse foetal development: translational inactivation of globin genes during the terminal differentiation of yolk sac erythroid cells.
abstract: The molecular mechanism of globin genes inactivation has been explored at the translational level in yolk sac erythroid cells from mouse foetuses. Ageing of the messenger molecules is paralleled by a progressive decrease of the poly(A) tail. Poly(A) less messengers are less active when tested in a wheat germ cell free system and become uncapable to terminate globin chain elongation.
mesh_terms: D000367:Age Factors; D000818:Animals; D004920:Erythropoiesis; D005260:Female; D006454:Hemoglobins / Q000096:biosynthesis*; D051379:Mice; D008810:Mice, Inbred C57BL; D011061:Poly A / Q000378:metabolism; D011132:Polyribosomes / Q000378:metabolism*; D014176:Protein Biosynthesis; D012333:RNA, Messenger / Q000378:metabolism*; D014817:Vitelline Membrane / Q000166:cytology / Q000378:metabolism*
chemical_list: D006454:Hemoglobins; D012333:RNA, Messenger; D011061:Poly A