Isolated perfused rabbit lung: a critical appraisal.
The isolated perfused lung (IPL), when compared to available in vitro and in vivo pulmonary systems, is a preparation that fulfills a majority of the ideal criteria for studying metabolism, binding and/or physiological response to xenobiotics. The IPL is an exceptionally useful method when there is a need for concurrent administration of multiple agents in different physical forms. Various details such as physiological and biochemical parameters and the construction of a small animal tracheal valve system are discussed.
D000818:Animals; D001580:Benzopyrenes / Q000008:administration & dosage / Q000097:blood / Q000378:metabolism; D001794:Blood Pressure; D002584:Cervix Uteri / Q000502:physiology; D005260:Female; D066298:In Vitro Techniques; D007700:Kinetics; D008168:Lung / Q000378:metabolism / Q000502:physiology*; D008722:Methods; D010477:Perfusion; D011817:Rabbits; D012039:Regional Blood Flow
D001580:Benzopyrenes