[Antiandrogenic effect of spirolactones: different mechanisms of action (author's transl)].
The spirolactones decrease the plasma testosterone levels in men. They also inhibit the specific dihydrotestosterone binding to rat prostate, and have no effect on 5 alpha-reductase. The spirolactones are antiandrogenic drugs, acting at several levels.
D000726:Androgen Antagonists; D000818:Animals; D002191:Canrenoic Acid / Q000494:pharmacology*; D013196:Dihydrotestosterone / Q000378:metabolism; D006801:Humans; D008297:Male; D011245:Pregnadienes / Q000494:pharmacology*; D011467:Prostate / Q000187:drug effects; D051381:Rats; D013148:Spironolactone / Q000494:pharmacology*; D013739:Testosterone / Q000097:blood
D000726:Androgen Antagonists; D011245:Pregnadienes; D013196:Dihydrotestosterone; D013148:Spironolactone; D013739:Testosterone; D002191:Canrenoic Acid
Effets anti-androgéniques des spirolactones: différents modes d'action