title: [Reactogenicity and immunologic effectiveness of cholerogen-anatoxin. Feasibility of revaccination with cholerogen-anatoxin, determination of optimal doses and times for administration].
abstract: The authors discussed the results of study of the titre of vibration antibodies and antitoxins one, three and five months after the vaccination of adults with an optimal vaccination dose of cholerogen toxoid (24OO BU). Comparison of the immunological information obtained at the above mentioned periods showed the expediency of revaccination three months after the vaccination. Immunogenicity of the three doses of the cholerogen-toxoid tested (1200, 2400, 3600 BU) displayed no statistically significant difference in revaccination. Taking into consideration that the least reactogenic dose was 1200 BU this dose is recommended as the optimal revaccination dose for adults.
mesh_terms: D000293:Adolescent; D000907:Antibodies, Bacterial / Q000096:biosynthesis; D000992:Antitoxins / Q000096:biosynthesis; D002771:Cholera / Q000276:immunology / Q000517:prevention & control*; D006801:Humans; D007117:Immunization, Secondary; D012703:Serotyping; D014121:Toxoids / Q000008:administration & dosage*; D014611:Vaccination; D014734:Vibrio cholerae / Q000276:immunology
chemical_list: D000907:Antibodies, Bacterial; D000992:Antitoxins; D014121:Toxoids
vernacular_title: Izuchenie reaktogennosti i immunologicheskoĭ éffektivnosti kholerogena-anatoksina. Izuchenie tselesoobraznosti revaktsinatsii kholerogenom-anatoksinom. epredelenie optimal'nykh doz i srokov ee provedeniia