[Myocardial blood flow and ventricular function in dependence on the size of myocardial infarct].
In eight dogs three branches of the left anterior descending coronary artery were occluded by successive ligations. Each time coronary flow reserve was measured by injecting dipyridamole (0.4 mg.kg-1). After an infarction of 13% of the left ventricle there was a significant decrease of Vmax and dp/dtmax (p less than 0.05). Measurements of regional myocardial blood flow detected an infarction of 5% of the left ventricle, whereas the total myocardial blood flow was reduced significantly when 17% of the left ventricle was infarcted.
D000818:Animals; D003097:Collateral Circulation / Q000187:drug effects; D003331:Coronary Vessels / Q000503:physiopathology*; D004176:Dipyridamole / Q000494:pharmacology; D004285:Dogs; D006352:Heart Ventricles / Q000503:physiopathology; D009200:Myocardial Contraction / Q000187:drug effects; D009203:Myocardial Infarction / Q000503:physiopathology*
D004176:Dipyridamole
Myokarddurchblutung und Ventrikelfunktion in Abhängigkeit von der Infarktgrösse.