Studies on the lymphoid system of mice with lethal acute toxoplasmosis.
Acute toxoplasmosis was induced in CFLP mice by infecting them intraperitoneally with the 25 x 10(3) multiplicity of the virulent RH strain of Toxoplasma gondii. The lymphoid system of mice succumbing to acute toxoplasmosis showed characteristic changes. Significant spleen hypertrophy (spleen index: 1.76), severe thymus atrophy (thymus index: 0.27) and a striking decrease of the lymphocyte count in blood (86%) was found as compared with the uninfected controls.
D000208:Acute Disease; D000818:Animals; D001284:Atrophy; D005260:Female; D006984:Hypertrophy; D007958:Leukocyte Count; D008208:Lymphatic System / Q000473:pathology*; D008214:Lymphocytes; D008297:Male; D051379:Mice; D009929:Organ Size; D013154:Spleen / Q000473:pathology; D013950:Thymus Gland / Q000473:pathology; D014123:Toxoplasmosis / Q000097:blood / Q000473:pathology*