Erythrocyte glutathione metabolism in cobalt-deficient goats.
Cobalt deficiency was produced in goats by feeding them rhode grass hay. The deficient animals excreted increased amounts of methyl malonic acid in their urine, indicating a lack of vitamin B12. Erythrocyte reduced glutathione levels increased with the onset of anemia. There was a concomitant increase in the levels of erythrocyte glutathione reductase (GSSG NADPH Reductase) and glutathione peroxidase (GSH:H2O2 peroxidase)during deficiency. These results are compared with similar observations reported for vitamin B12 deficiency in humans.
D000748:Anemia, Macrocytic / Q000209:etiology; D000821:Animal Feed; D000818:Animals; D003035:Cobalt / Q000172:deficiency*; D004912:Erythrocytes / Q000378:metabolism*; D005260:Female; D005978:Glutathione / Q000097:blood*; D005979:Glutathione Peroxidase / Q000097:blood; D005980:Glutathione Reductase / Q000097:blood; D006041:Goats / Q000378:metabolism*; D006801:Humans; D008297:Male; D008764:Methylmalonic Acid / Q000652:urine; D006109:Poaceae; D014806:Vitamin B 12 Deficiency / Q000209:etiology
D003035:Cobalt; D008764:Methylmalonic Acid; D005979:Glutathione Peroxidase; D005980:Glutathione Reductase; D005978:Glutathione