title: A cybernetic approach to the origin of the genetic coding mechanism. I. Methodological principles.
abstract: It is postulated that some quasi-deterministic code features (universality, connectedness, systematic degeneracy, symmetry, regularity and so on) resulted from unique (and therefore universal) relization of a stochastic evolutionary process. The evolution of real genetic systems should satisfy the principle of succession; that is, loss of a feature that is necessary for a genetic system means death to its carrier. The hypothesis of unique key coincidence is proposed which indicates the mechanisms of arising of the primary correspondence between the linear structures of polynucleotides and polypeptides. If the collinear coincidence was to appear in the key positions of pra-protein with, at least, some of the primitive properties of the pra-amino-acyl-t-RNA-synthetase required for the accelerated recognition of the key positions of pra-template, the positive feed-back mechanism in the system would be most short-circuited so that the repetitive reproduction of pra-synthetase would be much accelerated.
mesh_terms: D000604:Amino Acyl-tRNA Synthetases; D005075:Biological Evolution; D003491:Cybernetics; D005246:Feedback; D005815:Genetic Code; D009711:Nucleotides; D010455:Peptides; D011506:Proteins
chemical_list: D009711:Nucleotides; D010455:Peptides; D011506:Proteins; D000604:Amino Acyl-tRNA Synthetases