Treatment of meningeal leukemia.
Chemotherapy via the intrathecal and intraventricular routes with the use of up to three drugs plus radiotherapy have produced remissions so prolonged that it is now practical to think of a "cure" rather than simple palliation of this disease. A promising treatment protocol is described in which radiotherapy is combined with and followed by intraventricular methotrexate and cytosine arabinoside.
D002404:Catheterization; D002493:Central Nervous System Diseases; D002648:Child; D002675:Child, Preschool; D003561:Cytarabine / Q000008:administration & dosage; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D006854:Hydrocortisone / Q000008:administration & dosage; D007276:Injections, Intraventricular / Q000379:methods; D007278:Injections, Spinal; D007938:Leukemia / Q000188:drug therapy / Q000532:radiotherapy / Q000628:therapy*; D008727:Methotrexate / Q000008:administration & dosage / Q000134:cerebrospinal fluid
D003561:Cytarabine; D006854:Hydrocortisone; D008727:Methotrexate