Comparison of xylitol and glucose metabolism in nonhepatic rat tissues.
Capability and extent of xylitol metabolism in vitro was studied in a variety of non-hepatic tissues of rats, using enzymatic and isotopic methods. Only kidney was found to be able to utilize xylitol at a significant rate while in all other organs tested - lung, brain, heart muscle, skeletal muscle and adipose tissue - no uptake of xylitol was detectable using two independent methods. In accordance with these results the incorporation of radioactivity from [U-14C]-xylitol as substrate into the products CO2 and lactate was found to be very small in all organs with the exception of kidney and when compared to that from [U-14C]-glucose it was less than 5%. From these results it is concluded that besides liver only kidney can utilize xylitol to a significant extent while for the other tissues studied xylitol is not a suitable substrate.
D000273:Adipose Tissue / Q000166:cytology / Q000378:metabolism; D000818:Animals; D001921:Brain / Q000378:metabolism; D002245:Carbon Dioxide; D005947:Glucose / Q000378:metabolism*; D007668:Kidney / Q000378:metabolism; D007773:Lactates / Q000378:metabolism; D008168:Lung / Q000378:metabolism; D008297:Male; D009132:Muscles / Q000378:metabolism; D009206:Myocardium / Q000378:metabolism; D009928:Organ Specificity; D051381:Rats; D014993:Xylitol / Q000378:metabolism*
D007773:Lactates; D002245:Carbon Dioxide; D005947:Glucose; D014993:Xylitol