Amino-oxidase and dermal connective tissue in scoliosis.
The amino-oxidase and collagen content of dermal tissue was evaluated in 10 patients with severe idiopathic scoliosis and in a control group of 7 patients with poliomyelitic scoliosis, that were to undergo surgical correction of their skeletal deformity. A greater dermal content of neutral salt souble collagen was found in the patients with idiopathic scoliosis, compared with the control group. Statistically the difference was highly significant. Mono-amino-oxidase activity, however, was found to be significantly decreased in dermal extracts obtained from patients affected by idiopathic scoliosis in comparison with controls. The involvement of mono-amino-oxidase in the crosslinking of collagen and the possible classification of idiopathic scoliosis as a systemic disease of connective tissue are discussed.
D000293:Adolescent; D000328:Adult; D000818:Animals; D002417:Cattle; D002648:Child; D003094:Collagen / Q000378:metabolism; D003238:Connective Tissue / Q000201:enzymology*; D005260:Female; D006601:Hexoses / Q000378:metabolism; D006801:Humans; D008297:Male; D008875:Middle Aged; D000587:Oxidoreductases Acting on CH-NH Group Donors / Q000378:metabolism*; D051381:Rats; D012600:Scoliosis / Q000201:enzymology* / Q000378:metabolism; D012867:Skin / Q000201:enzymology* / Q000378:metabolism; D013552:Swine
D006601:Hexoses; D003094:Collagen; D000587:Oxidoreductases Acting on CH-NH Group Donors