[Animal-experiment studies on the pathogenesis of peptic ulcer in the newborn].
Gastric secretion was studied in 188 fetuses of 28 pregnant dogs near term. Baseline secretory values were determined and gastric secretion was stimulated in additional fetuses with histamine, insulin, or gastrin. A significant increase in volume, acidity and pepsin output was observed in fetuses stimulated during the last week of gestation. Following maternal stimulation the placental transfer of histamine, insulin, and gastrin are demonstrated.
D000818:Animals; D000831:Animals, Newborn; D004285:Dogs; D005260:Female; D005750:Gastric Juice / Q000378:metabolism; D005753:Gastric Mucosa / Q000166:cytology; D005755:Gastrins / Q000494:pharmacology; D005865:Gestational Age; D006632:Histamine / Q000494:pharmacology; D007328:Insulin / Q000494:pharmacology; D010437:Peptic Ulcer / Q000209:etiology*; D011247:Pregnancy; D013268:Stimulation, Chemical; D013270:Stomach / Q000502:physiology
D005755:Gastrins; D007328:Insulin; D006632:Histamine
Tierexperimentelle Untersuchungen zur Pathogenese des peptischen Ulcus beim Neugeborenen.