Effect of ethyl apovincaminate on cerebral circulation of dogs under normal conditions and in arterial hypoxia.
Effects of 1, 2 and 4 mg/kg i.v. doses of ethyl apovincaminate (RGH-4405, Cavinton) on cerebral blood flow, determined in the internal carotid and vertebral artery, were studied in anaesthetized dogs under 21, 16 and 11% O2 inhalation. Total cerebral blood flow was increased by 4 mg/kg Cavinton under normal O2 and between 100 to 200 mmHg perfusion pressures, while 2 mg/kg doses were effective under hypoxia. Similar phenomena were observed in the carotid and vertebral flow, separately. Arterial hypoxia seems to potentiate the effect of Cavinton on cerebral blood flow.
D000818:Animals; D002560:Cerebrovascular Circulation / Q000187:drug effects*; D004285:Dogs; D005260:Female; D002534:Hypoxia, Brain / Q000188:drug therapy / Q000503:physiopathology*; D008297:Male; D014748:Vinca Alkaloids / Q000494:pharmacology*
D014748:Vinca Alkaloids