title: Effect of calcium content of diet on absorption of diphenylhydantoin.
abstract: The effect produced by changes in the calcium content of the diet on the plasma concentration of diphenylhydantoin was studied. In subjects on a high calcium intake, plasma diphenylhydantoin levels were significantly lowered, probalby resulting from both the formation of an insoluble calcium-drug complex and the direct effect of calcium on the intestinal membrane. A similar but less pronounced effect was observed when calcium-rich foods were excluded from the diet. These observations indicate the need for a balanced calcium diet during diphenylhydantoin treatment.
mesh_terms: D002118:Calcium / Q000097:blood; D002136:Calcium, Dietary; D006801:Humans; D007408:Intestinal Absorption; D007413:Intestinal Mucosa / Q000378:metabolism; D008297:Male; D010672:Phenytoin / Q000097:blood* / Q000378:metabolism
chemical_list: D002136:Calcium, Dietary; D010672:Phenytoin; D002118:Calcium