The effect of perfume "ageing" on the allergenicity of individual perfume ingredients.
An ingredient of a perfume which is a sensitizer may become hypoallergenic by interacting with other ingredients during the ageing process of the perfume. Thus, a patient with an exquisite allergic sensitivity to cinnamic aldehyde tolerates two perfumes containing cinnamic aldehyde without acquiring a dermatitis. There are several theories of why cinnamic aldehyde can become a non-sensitizer in a perfume mixture. Testing with a mature perfume may be much more significant than testing with individual ingredients.
D000447:Aldehydes / Q000009:adverse effects; D003877:Dermatitis, Contact / Q000175:diagnosis / Q000209:etiology*; D005260:Female; D006801:Humans; D008875:Middle Aged; D010328:Patch Tests; D010476:Perfume / Q000009:adverse effects*; D013997:Time Factors
D000447:Aldehydes; D010476:Perfume