[Effect of hydrocortisone acetate on carbohydrate metabolism and cellular respiration of lymphoma NK/ly].
Hydrocortisone acetate caused the inhibition of the limphoma cells growing. In the process the aerobic glycolysis was increased, the respiratory activity was altered slightly but the magnitude of Crebtry effect was distinctly decreased. Under effect of the hormone the activity of pentose pathway was drastically increased: oxidation via 6-phosphogluconate and the synthesis of phosphorylated carbohydrates by "non-oxidative" pathway were increased 1.7- and 7.4-fold, respectively. Thus, the stopping of the tumor cells development occurred with simultaneous activation of the pentose-phosphate pathway and energy metabolism as a whole.
D000818:Animals; D050260:Carbohydrate Metabolism; D006019:Glycolysis; D006854:Hydrocortisone / Q000494:pharmacology*; D007773:Lactates / Q000096:biosynthesis; D008223:Lymphoma / Q000378:metabolism / Q000473:pathology*; D008297:Male; D051379:Mice; D009374:Neoplasms, Experimental / Q000378:metabolism / Q000473:pathology; D010101:Oxygen Consumption; D010428:Pentosephosphates / Q000378:metabolism; D011773:Pyruvates / Q000378:metabolism
D007773:Lactates; D010428:Pentosephosphates; D011773:Pyruvates; D006854:Hydrocortisone
Vliianie gidrokortizonatsetata na uglevodnyi obmen i dykhanie kletok limfomy nK/Li