[Effect of mellaril on the liver lysosomes of rats with acute toxic hepatitis].
In 24 hours after a single administration of melleril (30 mg/kg) an elevated injuriousness of "heavy" and "light" liver lysosomes of rats subjected to "in vitro" treatment with a pH 5.0 solution at 37 degrees was recorded. Introduction of melleril to rats with toxic CCl4-induced hepatitis (CCl4 dosage of 0.15 ml per 100 g body weight) depresses free activity of acid phosphatase, this fall, however, failing to reach the corresponding values in intact animals. An elevated injuriousness of "heavy" and "light" lysosomas undergoing treatment at pH 5.0 and 37degrees, revealed in all variants of the tests, is related to activation of lysosomal phospholipases with subsequent liberation of surfactant lipids and volumetric changes of the particles.
D000135:Acid Phosphatase / Q000037:antagonists & inhibitors / Q000378:metabolism; D000208:Acute Disease; D000818:Animals; D002252:Carbon Tetrachloride Poisoning; D056486:Chemical and Drug Induced Liver Injury / Q000473:pathology*; D003864:Depression, Chemical; D005260:Female; D066298:In Vitro Techniques; D008099:Liver / Q000473:pathology*; D008247:Lysosomes / Q000201:enzymology*; D051381:Rats; D013881:Thioridazine / Q000494:pharmacology*
D000135:Acid Phosphatase; D013881:Thioridazine
Vliianie mellerina na lizosomy pecheni krys s ostrym toksicheskim gepatitom.