title: The formation of heteroagglutinins in rats "chemically" splenectomized by ethyl palmitate, in comparison to animals surgically splenectomized.
abstract: In Wistar rats "chemically splenectomized" by an i.v. injection of ethyl palmitate the formation of heteroagglutinins against human O-erythrocytes has been followed. Ethyl palmitate applied 2 hrs before immunization induced on the 5th day a significant decrease of the antibody level. This temporary inhibition, however, was at a later stage replaced by a significant increase of antibody level with the peak of 8--14 days. Animals surgically splenectomized 24 hrs prior to immunization displayed a weak antibody response throughout the experiment. An injection of the ethyl palmitate on the 6th day after immunization induced a pronounced and persistent decrease of the antibody level. Surgical splenectomy performed within the same interval had a comparable effect. The experiments revealed that the inhibitory effect of ethyl palmitate on antibody production was temporary only, and at a later stage could be compensated by an enhanced antibody activity.
mesh_terms: D000373:Agglutinins / Q000302:isolation & purification*; D000818:Animals; D000910:Antibodies, Heterophile; D000917:Antibody Formation; D008297:Male; D010168:Palmitates / Q000494:pharmacology*; D010169:Palmitic Acids / Q000494:pharmacology*; D051381:Rats; D013154:Spleen / Q000187:drug effects* / Q000276:immunology; D013156:Splenectomy
chemical_list: D000373:Agglutinins; D000910:Antibodies, Heterophile; D010168:Palmitates; D010169:Palmitic Acids