Dopaminergic influence on withdrawal jumping behavior in morphine-dependent mice.
Abrupt withdrawal jumping behavior in morphine-dependent mice is accompanied by a decrease in brain dopamine turnover and an increase in brain dopamine level which parallel strain differences in jumping incidence. Both naloxone-precipitated and abrupt withdrawal jumping behavior are inhibited in a dose-dependent manner by the dopaminergic agonist apomorphine. A cataleptic dose of the dopaminergic antagonist, haloperidol, does not block naloxone-precipitated jumping, but does significantly block the inhibition by apomorphine. These findings indicate that there may be a decrease release of dopamine in the brain during the expression of withdrawal jumping behavior and that dopaminergic activation may be inhibitory to this behavior.
D000818:Animals; D001058:Apomorphine / Q000494:pharmacology; D001921:Brain / Q000378:metabolism; D004298:Dopamine / Q000378:metabolism / Q000502:physiology*; D004305:Dose-Response Relationship, Drug; D006220:Haloperidol / Q000494:pharmacology; D006801:Humans; D008297:Male; D008781:Methyltyrosines / Q000494:pharmacology; D051379:Mice; D008813:Mice, Inbred ICR; D008815:Mice, Inbred Strains; D009021:Morphine Dependence / Q000378:metabolism / Q000503:physiopathology*; D009043:Motor Activity / Q000187:drug effects; D009270:Naloxone / Q000008:administration & dosage / Q000494:pharmacology; D013045:Species Specificity; D013375:Substance Withdrawal Syndrome / Q000378:metabolism / Q000503:physiopathology*
D008781:Methyltyrosines; D009270:Naloxone; D006220:Haloperidol; D001058:Apomorphine; D004298:Dopamine