Influence of kinins on amphetamine activity.
Bradykinin (2 mug ivc) or kallikrein (40 U/kg) inhibited the stimulatory psychomotoric action of a low (0.5 mg/kg) dose of amphetamine, and potentiated the action of a high (2 mg/kg) dose of the drug. A treatment with bradykinin and the low dose of amphetamine reduced the noradrenaline and enhanced the serotonin level in the striatum, and lowered the dopamine content in the cortex, while a combined treatment with the high dose of amphetamine elevated the dopamine level in the striatum and hypothalamus and depressed the serotonin level in the midbrain.
D000661:Amphetamine / Q000494:pharmacology*; D000818:Animals; D001679:Biogenic Amines / Q000032:analysis; D001920:Bradykinin / Q000494:pharmacology*; D001923:Brain Chemistry / Q000187:drug effects; D004347:Drug Interactions; D007610:Kallikreins / Q000494:pharmacology*; D009043:Motor Activity / Q000187:drug effects; D051381:Rats
D001679:Biogenic Amines; D000661:Amphetamine; D007610:Kallikreins; D001920:Bradykinin