Structure-activity relationship for antitumor thiosemicarbazones.
The in vitro antitumore activity of a series of thiosemicarbazones was studied by means of the Free-Wilson method. Both lipophilic and electronic effects are shown to play an important role.
D000970:Antineoplastic Agents / Q000627:therapeutic use*; D006801:Humans; D008954:Models, Biological; D009369:Neoplasms / Q000188:drug therapy; D013329:Structure-Activity Relationship; D013882:Thiosemicarbazones / Q000627:therapeutic use*
D000970:Antineoplastic Agents; D013882:Thiosemicarbazones