Analysis of drug decomposition products. Part 34. Gas chromatography method for quantitative determination of METET in the presence of its sulfoxide.
Gas chromatographic method for the determination of METET in the presence of its oxydation product sulfoxide was worked out. The gas chromatographic conditions were: gas chromatograph--Chrom4CSSR,FID,N2-flow20--30cm3/min glass, column 100 cm, phi 0-2 cm, 10% SE-30 on Chromosorb W 100/120 mesh, temp. 180--200 degrees C. The determination was carried by means of internal standard (phenylbutazone--PhB--1,2-diphenyl 4n-butyl pyrazolidino-3,5-dione or aminophenazone--APh--1-phenyl-2,3-dimethyl-4-dimethylamino-pyrazolone-5) and the calibration curve was prepared. The ratio of peak heights for the determined comound and the standard was considered. The error of the METET determination expressed as standard percentage deviation was sr = 2--3% at n = 10.
D002849:Chromatography, Gas; D008722:Methods; D013806:Theophylline / Q000031:analogs & derivatives* / Q000032:analysis
C001719:metet; D013806:Theophylline