[Effect of kynurenine and its metabolites on the concentration of 11-hydroxycorticosteroids in rat plasma].
Injections of kynurenine (10 and 25 mg/kg, i.p.) and nicotinic acid (50 mg/kg i.p.) produced a marked increase in concentration of 11-hydroxycorticosteroids (11-HCS) in rat blood plasma. Effect of nicotinic acid was not prevented by dexamethazone (0.6 mg/kg). Subtreshold dose of nicotinic acid (10 mg/kg) enhanced a rise in 11-HCS produced by swimming stress. 3-hydroxykynurenine, 3-hydroxyanthranilic, antranilic picolinic and quinolinic acids (10-50 mg/kg) did not change the concentration of 11-HCS. It is suggested that some of the biochemical and pharmacological effects of injected kynurenine can be mediated through the rise of 11-HCS in blood.
D015062:11-Hydroxycorticosteroids / Q000097:blood*; D015095:3-Hydroxyanthranilic Acid / Q000494:pharmacology; D000818:Animals; D007737:Kynurenine / Q000494:pharmacology*; D008297:Male; D009539:Nicotinic Acids / Q000494:pharmacology; D010848:Picolinic Acids / Q000494:pharmacology; D011805:Quinolinic Acids / Q000494:pharmacology; D051381:Rats; D062367:ortho-Aminobenzoates / Q000494:pharmacology
D015062:11-Hydroxycorticosteroids; D009539:Nicotinic Acids; D010848:Picolinic Acids; D011805:Quinolinic Acids; D062367:ortho-Aminobenzoates; D015095:3-Hydroxyanthranilic Acid; D007737:Kynurenine
Vliianie kinurenina i ego metabolitov na kontsentratsiiu 11-oksikortikosteroidov v plazme krovi krys