Experimental examinations on the suitability of organoaminomethane-bis-phosphonic acids for bone-scintigraphy by means of Tc-99m in animals.
Phosphororganic compounds of the general formula R2N-CH (PO(OH)2)2 were examined for their Tc-99m-labelability and suitability for bone-scintigraphy. Compared to Tc-99-m-Sn-EHDP (Hydroxyethane-1,1-diphosphonic acid), four compounds showed a better concentration in the sceleton, while three compounds remained beneath comparative values.
D000818:Animals; D001842:Bone and Bones / Q000032:analysis; D055598:Chemical Phenomena; D002621:Chemistry; D008297:Male; D063065:Organophosphonates / Q000032:analysis / Q000633:toxicity; D011877:Radionuclide Imaging; D051381:Rats; D013667:Technetium
D063065:Organophosphonates; D013667:Technetium