[Effect of coronary flow reduction on the coronary flow distribution, the myocardial metabolism and left ventricular hemodynamics].
Myocardial blood flow, left ventricular performance, regional myocardial metabolites (ATP, CrP, lactate) and a-v differences of oxygen, lactate and pyruvate were determined in 6 open chest dogs with cannulated left coronary artery. A mean flow reduction from 92 to 43 ml/min/100 g heart weight resulted in marked heart failure accompanied by extensive flow reduction to the endocard with nearly 10 fold increase of lactate and a decrease of CrP content to 50% of control. In contrast, flow and metabolic parameters of the epicardial part changed only slightly. Furthermore, the DPTI/SPTI-ratio showed a good correlation with the subendocardial CrP content (r = 0.93, p less than 0.01).
D000255:Adenosine Triphosphate / Q000378:metabolism; D000818:Animals; D001783:Blood Flow Velocity; D003331:Coronary Vessels; D004285:Dogs; D007773:Lactates / Q000378:metabolism; D009206:Myocardium / Q000378:metabolism*; D010725:Phosphocreatine / Q000378:metabolism
D007773:Lactates; D010725:Phosphocreatine; D000255:Adenosine Triphosphate
Einfluss der Koronarflussdrosselung auf die Koronarflussverteilung, den Herzmuskelmetabolismus und die linksventrikuläre Hämodynamik