[Effect of a glutamate and glutamine excess on the nucleic acid content of the spleen cell nuclei in rats].
In tests conducted with albino rats subject to investigation was the effect of sodium glutamate, or glutamine, daily introduced into the stomach in doses of 300 and 150 mg/kg, on the nucleic acids content in the splenic cell nuclei. All the animals taken in the experiment demonstrated a clearcut quantity of nucleonic RNA. By using a maximum dose of sodium glutamate and minimal one of glutamine a rise in the amount of DNA occurs in the nuclei of the splenic cells.
D000818:Animals; D002467:Cell Nucleus / Q000187:drug effects* / Q000378:metabolism; D004247:DNA / Q000378:metabolism*; D004305:Dose-Response Relationship, Drug; D005260:Female; D005492:Folic Acid / Q000494:pharmacology; D005971:Glutamates / Q000494:pharmacology*; D005973:Glutamine / Q000494:pharmacology*; D008297:Male; D012313:RNA / Q000378:metabolism*; D051381:Rats; D013154:Spleen / Q000648:ultrastructure*; D013268:Stimulation, Chemical; D013997:Time Factors
D005971:Glutamates; D005973:Glutamine; D012313:RNA; D004247:DNA; D005492:Folic Acid
Vliianie izbytka gliutamata i gliutamina na soderzhanie nukleimovykh kislot iader kletok selezenki krys