[Toxic effect of phosphamide after simultaneous entrance into the body through the gastrointestinal tract and respiratory organs].
The experiment involved an investigation into the action of O,O-dimethyl-S-(N-methyl-carbomoilmethyl)-dithiophosphate (phosphamide), used at the level of the liminal dose (4 mg/kg) and in a concentration of 1.9 mg/m3, as compared with the effect of 1/2 of the liminal dose and 1/2 of the thereshold concentration. Both were simultaneously introduced into the organism of test albino rats for a period of 4 months and their complex action showed an intensification of the toxic effect. In evidence was also a more marked anticholinesterase action, a higher level of the insecticide in biological substrates and greater changes of hematological indices.
D000284:Administration, Oral; D000336:Aerosols; D000818:Animals; D001772:Blood Cell Count; D001921:Brain / Q000201:enzymology; D002800:Cholinesterase Inhibitors; D004117:Dimethoate / Q000008:administration & dosage / Q000494:pharmacology / Q000633:toxicity*; D004912:Erythrocytes / Q000473:pathology; D007668:Kidney / Q000201:enzymology; D007962:Leukocytes / Q000473:pathology; D008099:Liver / Q000201:enzymology; D008297:Male; D051381:Rats
D000336:Aerosols; D002800:Cholinesterase Inhibitors; D004117:Dimethoate
O toksicheskom deĭstvii fosfamida pri odnovremennom postuplenii v organizm cherez zheludochno-kishechnyĭ trakt i organy dykhaniia.