The effect of furosemide stimulation on renin secretion and its application in examining activity of the renin-angiotensin system.
The response of plasma renin concentration [PRC] to Furosemide administration and orthostasis stimulation was studied in 9 healthy volunteers and in 30 patients with essential hypertension. The results indicate that Furosemide is unfit for stimulation of renin secretion owing to a relatively high frequency of paradoxical PRC decreases observed both in hypertensives and normotensives. On the other hand, orthostasis stimulation is a manoeuvre suitable also for screening of low renin hypertension.
D000328:Adult; D000804:Angiotensin II / Q000097:blood*; D005260:Female; D005665:Furosemide / Q000494:pharmacology*; D006801:Humans; D006973:Hypertension / Q000097:blood; D008297:Male; D008875:Middle Aged; D009318:Natriuresis / Q000187:drug effects; D011187:Posture; D012083:Renin / Q000097:blood*; D013268:Stimulation, Chemical
D000804:Angiotensin II; D005665:Furosemide; D012083:Renin