[Dynamics of nonachlazine distribution in several rat organs following single and repeated administration].
Dynamics of nonachlazine, a new anti-anginal agent, distribution in organs following its single and repeated introduction in the form of a potion and aqueous solution was studied in tests with albino rats. It was ascertained that on introduction of a ready for use medicinal preparation (potion) the drug is absorbed by the blood and enters internal organs at a quicker pace than does its aqueous solution. The type of the medicinal preparation of the drug has no relevance to the rate of its elimination from the organism. With its repeated introduction (over a space of 12 days) the nonachlazine level in the heart and kidneys goes up, whereas its content in the blood and liver experiences but a slight change.
D000700:Analgesics / Q000008:administration & dosage / Q000378:metabolism*; D000818:Animals; D001921:Brain / Q000378:metabolism; D007668:Kidney / Q000378:metabolism; D008099:Liver / Q000378:metabolism; D008297:Male; D009206:Myocardium / Q000378:metabolism; D010640:Phenothiazines / Q000008:administration & dosage / Q000378:metabolism*; D010879:Piperazines / Q000008:administration & dosage / Q000378:metabolism*; D051381:Rats
D000700:Analgesics; D010640:Phenothiazines; D010879:Piperazines
Dinamika raspredeleniia nonakhlazina v nekotorykh organakh krys pri odnokratnom i povternom vvedenii