Ethanol preference in C57BL/6 and BALB/c mice at three ages and eight ethanol concentrations.
Eight ethanol concentrations (4%, 6%, 8%, 10%, 12%, 14%, 16%, 18%) were used. A reduction in ethanol preference with increasing age was seen in the C57BL/6 mice, but not in the BALB/c animals. For C57BL/6 mice the largest difference in ethanol preference occurred between the 10% and 18% ethanol solutions. It was found that the ethanol preference of the 14-16 mo. C57BL/6 mice was similar to the 7-9 mo. old C57BL/6 mice at the first 5 concentrations. For the remaining concentrations the 14-16 mo. mice more closely resembled the 22-24 mo. mice in ethanol preference. The results of this study suggested that increased age does not simply result in a reduction in ethanol preference, but is a function of the genotype and concentration of the ethanol solution.
D000375:Aging; D000428:Alcohol Drinking; D000818:Animals; D002755:Choice Behavior; D003657:Decision Making; D000431:Ethanol / Q000008:administration & dosage*; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D008810:Mice, Inbred C57BL; D008954:Models, Biological; D013045:Species Specificity
D000431:Ethanol