[Relationship between means of administration, concentration in the blood, organ distribution and excretion of prespidin-14C from the body].
Blood content, distribution among organs and tissues and passage from the organism of prospidine-C14 in rats, following its introduction per os and application to the skin in the form of an ointment, were studied. With these modes of introduction it is shown that prospidine and/or products of its biotransformation are capable of relatively quickly penerating through the wall of the gastro-intestinal tract and skin. However, specific radioactivity in the organs in such cases is scores of time lower than with intravenous administration. In case of the peroral introduction of the compound 72.3 per cent of the amount of the compound and/or of its metabolites administered are eliminated via the gastro-intestinal tract in two days.
D000284:Administration, Oral; D000818:Animals; D001711:Biotransformation; D007408:Intestinal Absorption; D008297:Male; D009824:Ointments; D010879:Piperazines / Q000008:administration & dosage*; D011447:Prospidium / Q000008:administration & dosage* / Q000097:blood / Q000378:metabolism; D051381:Rats; D012869:Skin Absorption; D013997:Time Factors
D009824:Ointments; D010879:Piperazines; D011447:Prospidium
Soderzhanie v krovi, raspredelenie po organam i vyvedenie iz organizma prospidina-14C v zavisimosti ot sposoba ego primeneniia