Experiments on the detection of the carcinogenic N-nitroso-dimethylamine in the urine of rats after oral administration of the analgesic amidopyrine and nitrite.
N-Nitroso-dimethylamine (NDMA) was excreted unchanged in the urine of rats after oral administration of the compound in amounts ranging from 0.003% at a dose of 2 mg/kg to 0.08% at a dose of 15 mg/kg. By measurement of the NDMA excreted after oral administration of amidopyrine and nitrite, the extent of nitrosation in vivo was estimated to be about 30%. For clinical investigation of NDMA formation in patients treated with amidopyrine, however, we consider this method to be too insensitive.
D000632:Aminopyrine / Q000009:adverse effects*; D000818:Animals; D004128:Dimethylnitrosamine / Q000652:urine*; D005260:Female; D009573:Nitrites; D009602:Nitrosamines / Q000652:urine*; D051381:Rats
D009573:Nitrites; D009602:Nitrosamines; D000632:Aminopyrine; D004128:Dimethylnitrosamine