title: [Inhibitory effect of alpha-methyl-1-adamantane methylamine hydrochloride (rimantadine) on RNA-dependent RNA polymerase induction in culture of cells, infected with influenza virus].
abstract: An anti-influenza preparation, rimantadine (alpha-methyl-1-adamantane methylamine hydrochloride) at concentrations of 10--25 mkg/ml depresses the RNA-dependent RNA polymerase induction in a culture of cells infected with influenza virus (fowl plague virus). The inhibitory effect is also observed 2 hours following cell infection. In vitro studies have demonstrated that rimantadine has no effect on the activity of virus-induced RNA-dependent RNA polymerase, as well as on that of RNA-dependent RNA polymerase associated with virus particles.
mesh_terms: D000218:Adamantane / Q000031:analogs & derivatives* / Q000494:pharmacology; D000998:Antiviral Agents / Q000494:pharmacology*; D001952:Bridged-Ring Compounds / Q000031:analogs & derivatives*; D002478:Cells, Cultured; D004790:Enzyme Induction / Q000187:drug effects; D009980:Influenza A virus; D012316:RNA Nucleotidyltransferases / Q000096:biosynthesis*; D012324:RNA-Dependent RNA Polymerase / Q000096:biosynthesis*; D014776:Virus Cultivation
chemical_list: D000998:Antiviral Agents; D001952:Bridged-Ring Compounds; D012316:RNA Nucleotidyltransferases; D012324:RNA-Dependent RNA Polymerase; D000218:Adamantane
vernacular_title: Ingibiruiushchee deistvie solianokislogo al'fa-metil-1-adamantanmetilamina (rimantadina) na induktsiiu RNK-zavisimoi RNK-polimerazy v kul'ture kletok, infitsirovannykh virusom grilla