Morphometric and autoradiographic investigation of the small and large intestinal mucosa of rats with chronic experimental renal insufficiency.
Following a previous study with experimental short-term, high-grade uremia the changes of the small and large intestinal mucosa of rats with surgically induced chronic renal insufficiency were analysed. A clear tendency to inhibition of the rate of the physiological cell regeneration by prolongation of the mitotic cycle in correlation to the degree of renal insufficiency could be demonstrated. There was a extension of the generation time up to 40% in ileum and up to 50% in the large intestine in the animal group with the relatively highest degree of renal insufficiency. This extension was mainly due to a prolongation of the postmitotic Gi-phase. At the same time the total number of crypt epithelia and of the regenerative cells in the enlarged crypts increased. The enlargement of the regenerative crypt population is interpreted as an adaptive compensation of the inhibition of the cell production by prolongation of the mitotic cycle. A damage of the differentiated surface epithelium could not be detected. The significance of the present results and their relationship to so-called uremic entero-colitis and to sprue-like changes of small intestinal mucosa in man is discussed.
D000818:Animals; D003106:Colon / Q000473:pathology; D004751:Enteritis / Q000209:etiology; D005260:Female; D007413:Intestinal Mucosa / Q000473:pathology*; D007421:Intestine, Small / Q000473:pathology; D007676:Kidney Failure, Chronic / Q000150:complications / Q000473:pathology*; D008938:Mitosis; D051381:Rats; D012038:Regeneration