title: [Effect of L-dopa on the gonadotropic function of the pituitary gland].
abstract: Chronic experiments were conducted on female rats. It was shown that administration of noradrenaline precursor l-DOPA in a dose of 20 mg/kg for a period  of 2 weeks led to the premature sexual maturation of the sexually immature rats, depressed the estrus, but increased the percentage of ovulations in adult rats with a normal cycle, restored the ovulation in 50% of rats with irregular anovular cycle and altered the correlation of the sexual cycle phases and the FSH and the LH level in the hypophysis. Administration of l-DOPA to rats with a spontaneous estrus restored the normal sexual cycle and ovulation in them. Prolonged administration of l-DOPA; (for 3 to 4 weeks) in a dose of 20 mg/kg and also the use of higher doses (100 mg/kg) produced a depressive effect on the gonadotropic function of the hypophysis.
mesh_terms: D000818:Animals; D001835:Body Weight / Q000187:drug effects; D003864:Depression, Chemical; D004305:Dose-Response Relationship, Drug; D004971:Estrus / Q000187:drug effects; D005260:Female; D005640:Follicle Stimulating Hormone / Q000378:metabolism* / Q000502:physiology; D007980:Levodopa / Q000008:administration & dosage / Q000494:pharmacology*; D007986:Luteinizing Hormone / Q000378:metabolism* / Q000502:physiology; D009929:Organ Size / Q000187:drug effects; D010060:Ovulation / Q000187:drug effects; D010902:Pituitary Gland / Q000187:drug effects* / Q000502:physiology; D011247:Pregnancy; D051381:Rats; D012741:Sexual Maturation / Q000187:drug effects
chemical_list: D007980:Levodopa; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone
vernacular_title: Vliianie L-dofa na gonadotropnuiu funktsiiu gipofiza.