The prothrombin time test: effect of varying citrate concentration.
Blood samples from 12 normal subjects and 46 patients on oral anticoagulants were divided so that each was anticoagulated with four concentrations of trisodium citrate solution in the range 0.09-0.15 M, 9 vol blood being added to 1 vol citrate solution in each case. Citrated blood haematocrit and plasma prothrombin time was measured on each subsample; 0.025 M CaCl2-solution was used for recalcification throughout. Three laboratories participated, each using a different prothrombin-time technique.
D000925:Anticoagulants; D002951:Citrates / Q000494:pharmacology*; D006400:Hematocrit; D006801:Humans; D011517:Prothrombin Time
D000925:Anticoagulants; D002951:Citrates