title: [Sensitivity of the early mouse embryos to antifolic preparation chloridine].
abstract: A study was made of antifolic preparation chloridine (2,4-diamino-5-p-chlorphenyl-6-ethylpyrimidine) on the cleavage of CBA mouse embryos. Chloridine failed to influence the development of early mouse embryos in the maternal organism and considerably inhibited the cleavage of embryos explanted into the chloridine-containing medium. Chloridine sensitivity in the mouse and rat embryos was compared and a conclusion was drawn on the absence of interspecies differences in their reaction to teratogen at the level of the embryonic cells.
mesh_terms: D000818:Animals; D002454:Cell Differentiation / Q000187:drug effects; D046508:Culture Techniques; D004622:Embryo, Mammalian / Q000187:drug effects*; D005260:Female; D051379:Mice; D011247:Pregnancy; D011739:Pyrimethamine / Q000008:administration & dosage / Q000494:pharmacology*; D013723:Teratogens / Q000494:pharmacology*; D015053:Zygote / Q000187:drug effects
chemical_list: D013723:Teratogens; D011739:Pyrimethamine
vernacular_title: Chuvstvitel'nost' k antifolievomu preparatu khloridinu rannykh zarodysheĭ mysheĭ.