Potentiometric and spectral investigations of anhydrotetracycline and its metal-ion complexes.
The interaction of various metal ions with anhydrotetracycline was investigated. A comparison of the UV-visible and fluorescence spectral characteristics of anhydrotetracycline and its metal-ion complexes with a number of modified anhydrotetracyclines in the presence of metal ions suggested that the C-11 oxygen was involved in metal-ion binding. Secondary binding was observed in the A-ring by circular dichroism when the primary site was blocked.
D002614:Chelating Agents / Q000032:analysis; D002942:Circular Dichroism; D008027:Light; D008670:Metals; D011199:Potentiometry; D013050:Spectrometry, Fluorescence; D013053:Spectrophotometry; D013056:Spectrophotometry, Ultraviolet; D013754:Tetracyclines / Q000032:analysis*
D002614:Chelating Agents; D008670:Metals; D013754:Tetracyclines