title: [Interaction of reversible inhibitors with the catalytic centers and allosteric sites of cholinesterases].
abstract: The kinetics of inhibition of the human red blood cell cholinesterase with galanthamine tacrine and oxazyl (ambenonium) and the effect of these drugs on chick, mouse, cat and rat blood plasma enzyme activity was studied. Galanthamine proved to bind with acetylcholinesterase in the anionic areas of the catalytic centres, oxazyl interacted in the area of the allosteric anionic site, and tacrin interacted with the hydrophobic areas of the enzyme.
mesh_terms: D000495:Allosteric Site / Q000187:drug effects; D000549:Ambenonium Chloride / Q000494:pharmacology; D000818:Animals; D001921:Brain / Q000201:enzymology; D002384:Catalysis; D002415:Cats; D002645:Chickens; D002800:Cholinesterase Inhibitors / Q000494:pharmacology*; D002802:Cholinesterases / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D004347:Drug Interactions; D004789:Enzyme Activation / Q000187:drug effects; D004912:Erythrocytes / Q000201:enzymology; D005702:Galantamine / Q000494:pharmacology; D006801:Humans; D006868:Hydrolysis; D007700:Kinetics; D051379:Mice; D013619:Tacrine / Q000494:pharmacology
chemical_list: D002800:Cholinesterase Inhibitors; D005702:Galantamine; D013619:Tacrine; D000549:Ambenonium Chloride; D002802:Cholinesterases
vernacular_title: Vzaimodeĭstvie obratimykh ingibitorov s kataliticheskimi tsentrami i allostericheskimi uchastkami kholiénsteraz