Influence of prostaglandins upon adenosine release and of adenosine upon prostaglandin release in the isolated rabbit heart.
Prostaglandin (PG) E1 with its high effect of coronary dilation causes a distinct increase in the adenosine release from the isolated rabbit heart (Langendorff technique). Compared to this, an equal dose of PGF2alpha increases the release of adenosine only to a small extent. Conversely, application of adenosine results in a considerable release of PG-like substances from the rabbit heart in vitro. The present investigations support the hypothesis that, apart from adenosine, PG's too, are involved in coronary regulation as modulators.
D000241:Adenosine / Q000097:blood / Q000494:pharmacology*; D000818:Animals; D003326:Coronary Circulation / Q000187:drug effects; D005260:Female; D006321:Heart / Q000187:drug effects*; D008297:Male; D009206:Myocardium / Q000378:metabolism*; D010477:Perfusion; D011453:Prostaglandins / Q000097:blood / Q000494:pharmacology*; D011817:Rabbits
D011453:Prostaglandins; D000241:Adenosine