title: [Proposal of a new procedure for the exploration of hepatocellular function. The trimethoxybenzene test (TMB)].
abstract: The authors propose a new method of exploration of liver cell function based on the study of demethylation of a rapidly assimilated atoxic compound, trimethoxybenzene (TMB) in dimethoxy-hydroxybenzene (DMHB). Whereas in normal subjects, the urinary excretion of the metabolites was rapid and marked, 180 mg within 3 hours after taking a 400 mg dose, in patients with liver cell failure, the excretion of DMHB was considerably reduced, 80 to 95% in cirrhosis.
mesh_terms: D001555:Benzene Derivatives / Q000378:metabolism; D006801:Humans; D008103:Liver Cirrhosis / Q000175:diagnosis; D008111:Liver Function Tests / Q000379:methods*
chemical_list: D001555:Benzene Derivatives
vernacular_title: Proposition d'un nouveau procédé d'exploration de la fonction hépatocellulaire. Le "test au triméthoxybenzène" (TMB)