Role of myocardial lipids in development of cardiac necrosis.
Significant alterations in fatty acyl composition of cardiac phospholipids and neutral lipids are induced by dietary cod liver oil in the rat. Increased dietary availability of docosahexaenoic acid (22:6 omega3) leads to extensive replacement of linoleic acid (18:2omega6) and arachidonic acid (20:4omega6) in phospholipids. Dietary cod liver oil (10%) reduces isoproterenol stress tolerance and results in increased development of cardiac necrosis and mortality following isoproterenol treatment. It is suggested that diminished catecholamine stress tolerance may be related to altered synthesis of prostaglandins or related products.
D000818:Animals; D001095:Arachidonic Acids / Q000378:metabolism; D004041:Dietary Fats; D007213:Indomethacin / Q000494:pharmacology; D007700:Kinetics; D050356:Lipid Metabolism; D008297:Male; D009206:Myocardium / Q000378:metabolism / Q000473:pathology*; D009336:Necrosis; D010105:Oxygenases / Q000378:metabolism; D010743:Phospholipids / Q000378:metabolism; D051381:Rats; D013329:Structure-Activity Relationship; D014280:Triglycerides / Q000378:metabolism
D001095:Arachidonic Acids; D004041:Dietary Fats; D010743:Phospholipids; D014280:Triglycerides; D010105:Oxygenases; D007213:Indomethacin