title: [Auto-perfused multi-organ preparations. III. Interpretation of histologic changes in perfused organs].
abstract: The functional instability of "multi-organ" preparations has been studied by morphological and histochemical assessment of 46 autoperfused heart-lung-kidney-liver-duodenopancreas preparations. The organs of the autoperfused preparations were damaged to different degrees, but the damage was always a function of perfusion time (1 to 3 hours). The liver suffered the most serious lesions (stagnation, oedema, hepatocytolysis, hydropic degeneration) but lesions such as interstitial haemorrhage and oedema though in a milder form appeared also in the  kidney. The heart structure was comparatively well preserved.
mesh_terms: D000818:Animals; D004285:Dogs; D004487:Edema / Q000473:pathology; D006470:Hemorrhage / Q000473:pathology; D006651:Histocytochemistry; D007668:Kidney / Q000473:pathology; D008099:Liver / Q000473:pathology; D008168:Lung / Q000473:pathology; D009206:Myocardium / Q000473:pathology; D009926:Organ Preservation; D010477:Perfusion; D013997:Time Factors; D014021:Tissue Preservation
vernacular_title: Selbstperfundierende-Multiorgan-Präparate; III. Deutung der histologischen Veränderungen der perfundierten Organe