Role of metabolic activation in the pathogenesis of chemically induced pulmonary disease: mechanism of action of the lung-toxic furan, 4-ipomeanol.
Many xenobiotics produce hepatic injury due to their metabolism in the liver to highly reactive electrophile intermediates which form covalent conjugates with nucleophilic cellular constituents. This presentation describes studies indicating that the production of chemically reactive metabolites by pulmonary metabolism of xenobiotics can also play a fundamental role in the pathogenesis of chemically induced lung disease.
D000818:Animals; D005260:Female; D005663:Furans / Q000378:metabolism / Q000494:pharmacology* / Q000633:toxicity; D006168:Guinea Pigs; D007928:Lethal Dose 50; D008168:Lung / Q000378:metabolism; D008171:Lung Diseases / Q000139:chemically induced / Q000378:metabolism*; D008297:Male; D051379:Mice; D008862:Microsomes, Liver / Q000378:metabolism; D011817:Rabbits; D051381:Rats; D013729:Terpenes / Q000378:metabolism / Q000494:pharmacology*; D013997:Time Factors; D014118:Toxins, Biological / Q000378:metabolism / Q000494:pharmacology*
D005663:Furans; D013729:Terpenes; D014118:Toxins, Biological; C001470:4-ipomeanol