title: [Experiments in the diagnosis and therapy of stylesiasis in sheep].
abstract: Tested were several methods for the diagnosis of sheep stylesiasis - the study of washings, successive decantation, flotation after Füleborn and with the use of zinc sulfide - obtaining no favourable results. Immunobiologic methods, such as the skin allergic test and the complement-fixation test had no practical diagnostic value either. Sheep infected with S. globipunctata reacted positively to antigens of M. expansa, M. benedeni, and A. centripunctata. A total of 15 anticestode agents were tested to treat stylesias-isaffected animals. Bithionol and lead arsenate caused the shedding of Stylesia strobilae up to 100 per cent, however, about 50 per cent of the scolexes with the necks, attached to the intestinal wall, remained intact and produced strobilae. Cyclosamide, dichlorophen, trichlorophen, sulphen, dibromsulphen, and sulfoxide removed the strobilae, but did not almost act on the scolexes and necks, which later on developed strobilae. Praciquantel (isochinoline-pyrazine, EMBAU, droncit-Bayer) at the rate of 15 mg/kg is 100 per cent effective against S. globipunctata, M. expansa, M. benedeni, M. automnalia, and A. centripunctata, and has been tested for the first time as an anticestode means against the Anoplocephalite parasites in sheep. It has no unpleasant odor and taste, is practically untoxic (therapeutic index over 20), and could be used in group treatment of sheep.
mesh_terms: D000818:Animals; D000923:Anticestodal Agents / Q000627:therapeutic use; D000941:Antigens / Q000008:administration & dosage; D002589:Cestoda / Q000276:immunology; D002590:Cestode Infections / Q000175:diagnosis / Q000188:drug therapy / Q000662:veterinary*; D003168:Complement Fixation Tests; D004341:Drug Evaluation / Q000662:veterinary; D010270:Parasite Egg Count / Q000379:methods; D012756:Sheep; D012757:Sheep Diseases / Q000175:diagnosis* / Q000188:drug therapy; D012882:Skin Tests / Q000379:methods
chemical_list: D000923:Anticestodal Agents; D000941:Antigens
vernacular_title: Opiti za diagnostika i terapiia na stileziozata po ovtsete