[Critical survey on liver microsome test, a system for detecting point mutations (author's transl)].
The host-mediated assay systems and the liver microsome test are compared considering carefully the advantages and disadvantages of the different systems regarding practice. The essay includes methodical problems as well as relevant questions for humans.
D000818:Animals; D001419:Bacteria / Q000187:drug effects; D001681:Biological Assay; D004353:Drug Evaluation, Preclinical / Q000379:methods; D006801:Humans; D051379:Mice; D008862:Microsomes, Liver / Q000187:drug effects*; D009153:Mutagens
D009153:Mutagens
Kritische Betrachtung zum Lebermikrosomentest, einem System zum Nachweis von Punktmutationen