[Kinetics of ampicillin, oxacillin and carbenicillin after a short intravenous infusion in man].
Within 5 min 5 g of ampicillin, oxacillin and carbenicillin, respectively, were administered i.v. to patients with normal kidney function. Plasma levels of the antibiotic activity were measured up to 6 h following the injection. Urine was collected at intervals up to 8 h and the cumulative urinary excretion calculated. Furtheron, biologic half-life, volumes of distribution, total and renal clearance and area under the serum level curve have been assessed for the one- and the two-compartment model. For this model the amounts of drug in central and peripheral compartments were simulated. The statistical evaluation resulted in a highly significantly better fit when the data were analyzed according to the two-compartment model. Despite of these differences the physiological consequences of using the parameters of the one-compartment model were not significantly different.
D000293:Adolescent; D000328:Adult; D000368:Aged; D000667:Ampicillin / Q000008:administration & dosage / Q000378:metabolism*; D002228:Carbenicillin / Q000008:administration & dosage / Q000378:metabolism*; D005260:Female; D006801:Humans; D007263:Infusions, Parenteral; D007700:Kinetics; D008297:Male; D008875:Middle Aged; D008962:Models, Theoretical; D010068:Oxacillin / Q000008:administration & dosage / Q000378:metabolism*
D000667:Ampicillin; D002228:Carbenicillin; D010068:Oxacillin
Zur Kinetik von Ampicillin, Oxacillin und Carbenicillin nach intravenöser Kurzinfusion beim Menschen