title: Formation of antibodies and immunoglobulins of various classes in persons vaccinated with warm antileptospirosis polyvalent vaccine.
abstract: The results of the observations of 2 groups of 372 persons during 10 months showed that a twofold inoculation of corpuscular heated 6-valent antileptospiral vaccine ensures the formation of 19S-antibodies. The ratio 19S/7S antibodies was determined by inactivation of IgM agglutinins with the help of 2-mercaptoethanol. Quantitative content of immunolglobulins (G, A and M) was determined in parallel with the reaction of agglutination by the method of simple radial diffusion. Immunoglobulins of the class M in the serum of vaccinated persons increased as compared with control, whereas the content of IgG did not rise and that of IgA decreased.
mesh_terms: D000293:Adolescent; D000328:Adult; D000372:Agglutination Tests; D000907:Antibodies, Bacterial / Q000096:biosynthesis*; D002648:Child; D005260:Female; D006801:Humans; D007074:Immunoglobulin G / Q000096:biosynthesis; D007075:Immunoglobulin M / Q000096:biosynthesis; D007136:Immunoglobulins / Q000096:biosynthesis*; D007922:Leptospirosis / Q000276:immunology* / Q000517:prevention & control; D008297:Male; D008875:Middle Aged; D014611:Vaccination
chemical_list: D000907:Antibodies, Bacterial; D007074:Immunoglobulin G; D007075:Immunoglobulin M; D007136:Immunoglobulins