Antithrombotic effects of sulfinpyrazone in animals: influence on fibrinolysis and sodium arachidonate-induced pulmonary embolism.
It has been shown that sulfinpyrazone stimulates fibrinolytic activity in various in vitro and in vivo test systems. In rats with kaolin-induced paw oedema this compound is able to restore the markedly prolonged euglobulin clot lysis time in an oral dose of 30 mg/kg, whereas salicylate and dipyridamole are somewhat less active in this respect. Beside these effects, sulfinpyrazone protects rabbits from arachidonate-induced sudden death after a single oral dose of 10-30 mg/kg.
D000818:Animals; D001095:Arachidonic Acids; D001777:Blood Coagulation / Q000187:drug effects; D005342:Fibrinolysis / Q000187:drug effects*; D006801:Humans; D008297:Male; D051379:Mice; D011655:Pulmonary Embolism / Q000139:chemically induced / Q000188:drug therapy*; D011817:Rabbits; D051381:Rats; D013442:Sulfinpyrazone / Q000494:pharmacology* / Q000627:therapeutic use; D013997:Time Factors; D014568:Urokinase-Type Plasminogen Activator / Q000494:pharmacology
D001095:Arachidonic Acids; D014568:Urokinase-Type Plasminogen Activator; D013442:Sulfinpyrazone