Dissolution of two-component solids.
The dissolution rates of compressed two-component mixtures were investigated. A good correlation between the composition of the solid and its observed dissolution rate was demonstrated by regression analysis. A model for dissolution was applied to compressed mixtures of aspirin-salicylic acid, aspirin-phenacetin, phenacetin-caffeine, and aspirin and caffeine (the last mixture complexes in solution).
D002626:Chemistry, Pharmaceutical; D003720:Densitometry; D004338:Drug Combinations; D008956:Models, Chemical; D011312:Pressure; D012044:Regression Analysis; D012995:Solubility; D013607:Tablets
D004338:Drug Combinations; D013607:Tablets