Ambivalent effect of protein binding on computed distributions of metal ions complexed by ligands in blood plasma.
Although the absolute concentrations of metal complexes in blood plasma are controlled by protein binding, the percentage distribution of transition metal ions amongst low molecular weight ligands is not. Thus, computer simulations which omit protein equilibria can nevertheless afford reliable information about such metals in the biofluid.
D003201:Computers; D008024:Ligands; D008670:Metals / Q000097:blood*; D008954:Models, Biological; D011485:Protein Binding
D008024:Ligands; D008670:Metals