Assumed identity of granulocyte-pyrogen (GP) and leukocytosis inducing factor (LIF).
Pyrogen obtained from granulocytes induces granulocytosis in normal, endotoxin-tolerant and spinal animals alike, whereas heat treatment destroys the granulocytosis inducing effect. It is concluded that GP and LIF are identical, or nearly identical, factors.
D000818:Animals; D005334:Fever / Q000139:chemically induced; D006098:Granulocytes / Q000187:drug effects / Q000502:physiology*; D007962:Leukocytes / Q000502:physiology*; D007964:Leukocytosis / Q000139:chemically induced / Q000503:physiopathology*; D008297:Male; D011749:Pyrogens / Q000494:pharmacology*; D011817:Rabbits
D011749:Pyrogens