[Intensification of cellular immune response by immunization of mice with the cells preincubated in interferon].
Mice F1(CBA X C57BL/6) were immunized intraperitoneally with a single injection of L-1210 cells preincubated in interferon or control "false" preparation. CBA mice were injected with MX-11 cells: similarly treated according to the same scheme. Injection of interferon-treated cells was accompanied by the enhancement of the cellular immune response. The greatest cytotoxic activity was possessed by the lymphocytes of mice to which M-11 cells were administered together with interferon in which the cells were formerly incubated.
D000818:Animals; D003470:Culture Media; D046508:Culture Techniques; D003601:Cytotoxicity Tests, Immunologic; D005260:Female; D007111:Immunity, Cellular; D007114:Immunization; D007372:Interferons / Q000494:pharmacology*; D007939:Leukemia L1210 / Q000276:immunology / Q000473:pathology; D008214:Lymphocytes / Q000276:immunology*; D008297:Male; D051379:Mice; D009374:Neoplasms, Experimental / Q000276:immunology / Q000473:pathology
D003470:Culture Media; D007372:Interferons
Usilenie kletochnogo immunnogo otveta pri immunizatsii mysheĭ kletkami, predvaritel'no inkubirovannymi v interferone.