Estrogens and endometrial cancer: aspects of etiology and survival rate.
With a clinical study it could be demonstrated, that the frequency of diabetes hypertension, estrogen effect in the vaginal smear and proliferative changes of the endometrium was significantly higher in patients with endometrial cancer than in a control group (p less than or equal to 0.001). Obesity was also significantly more frequent (0.02 less than p less than 0.01). In vitro studies demonstrated a significantly higher aromatization of androstendione to estrone in adipose tissue of endometrial cancer patients (p less than 0.01), indicating etiologic correlations between endometrial cancer and extraglandular estrone production. An additional clinical study indicated a better 5-years-survival rate if parameters, indicating endogenous estrogen effect were present.
D000273:Adipose Tissue / Q000378:metabolism; D000328:Adult; D000368:Aged; D000735:Androstenedione / Q000378:metabolism; D048909:Diabetes Complications; D004967:Estrogens / Q000502:physiology*; D004970:Estrone / Q000096:biosynthesis; D005260:Female; D006801:Humans; D006973:Hypertension / Q000150:complications; D008875:Middle Aged; D014594:Uterine Neoplasms / Q000150:complications / Q000378:metabolism / Q000503:physiopathology*; D014621:Vagina / Q000473:pathology
D004967:Estrogens; D004970:Estrone; D000735:Androstenedione