N-acetyl-beta-glucosaminidase of peripheral blood lymphocytes in patients with cancer of the larynx.
In 20 men, age 35 to 55 years, with cancer of the larynx of N-acetyl-beta-glucosaminidase in peripheral blood lymphocytes was determined cytochemically according to Hayashi's method. Numbers of enzyme-positive cells were counted with regard to the type of cytochemical reaction (granular, granular-diffuse, or diffuse), and to the number of enzyme-positive lysosomal granules within a single cell. In comparison to 20 healthy men, age 20 to 30 years, the following changes were noted in the patients: 1) the decrease of the total count of enzyme-negative lymphocytes; 2) the decrease of the total count of lymphocytes with granular type of reaction; 3) the increase of the counts of lymphocytes with granular-diffuse and diffuse type of reaction. The authors suggest that these changes could be related to the immune reaction of specific tumor antigens.
D000328:Adult; D000917:Antibody Formation / Q000187:drug effects; D000951:Antigens, Neoplasm; D001772:Blood Cell Count; D006596:Hexosaminidases / Q000097:blood*; D006651:Histocytochemistry; D006801:Humans; D007822:Laryngeal Neoplasms / Q000097:blood / Q000201:enzymology* / Q000276:immunology; D037102:Lectins / Q000494:pharmacology; D008213:Lymphocyte Activation / Q000187:drug effects; D008214:Lymphocytes / Q000201:enzymology*; D008247:Lysosomes / Q000201:enzymology; D008297:Male; D008875:Middle Aged
D000951:Antigens, Neoplasm; D037102:Lectins; D006596:Hexosaminidases