title: The prothrombin time test: effect of varying citrate concentration.
abstract: Blood samples from 12 normal subjects and 46 patients on oral anticoagulants were divided so that each was anticoagulated with four concentrations of trisodium citrate solution in the range 0.09-0.15 M, 9 vol blood being added to 1 vol citrate solution in each case. Citrated blood haematocrit and plasma prothrombin time was measured on each subsample; 0.025 M CaCl2-solution was used for recalcification throughout. Three laboratories participated, each using a different prothrombin-time technique.
mesh_terms: D000925:Anticoagulants; D002951:Citrates / Q000494:pharmacology*; D006400:Hematocrit; D006801:Humans; D011517:Prothrombin Time
chemical_list: D000925:Anticoagulants; D002951:Citrates