Studies on passive transfer of anti-dextran and anti-egg albumin reactivity in the rat.
We were unable, passively, to transfer reactivity against dextran to the skin or peritoneal mast cells of non-dextran-reactive rats, by using serum or material eluted at pH 3 from mast cells of spontaneously dextran-reactive rats. When the dextran-reactive donor rats had also been immunized against egg albumin (EA) with pertussis vaccine (inducing IgE anti-EA antibody), passive sensitivity against EA (but not against dextran) could easily be transferred. The results indicated that the anti-dextran reactivity is not due to IgE antibody. Systemic reactions against dextran and EA differed in pattern, supporting the concept that the two substances acted through different mechanisms.
D000707:Anaphylaxis / Q000276:immunology*; D000818:Animals; D000906:Antibodies; D003911:Dextrans / Q000276:immunology*; D007116:Immunization, Passive; D007073:Immunoglobulin E; D008297:Male; D008407:Mast Cells / Q000276:immunology*; D010047:Ovalbumin / Q000276:immunology; D051381:Rats; D012882:Skin Tests
D000906:Antibodies; D003911:Dextrans; D007073:Immunoglobulin E; D010047:Ovalbumin