[Production of extracellular plasmocoagulase in staphylococcus aureus exposed to 3,6-diaminoacridines].
A modified quantitative nephelometric method was used. It was shown that production of extracellular plasmocoagulase was depressed in the development of acridine-sensitive and acridine-resistant cultures of Staph. aureus in the fluid nutrient medium containing 3,6-diaminoacridines: acriflavine, proflavine, acridine yellow, acridine orange, acridine No. 40 and acridine No. 56; 3,6-diaminoacridines failed to lead to noncompetitive inhibition of staphylococcus plasmocoagulase. A disturbance of the regulation of the enzyme exit into the external environment can serve as the cause of depression of the extracellular plasmocoagulase production by Staph. aureus.
D000166:Acridines / Q000494:pharmacology*; D000167:Acriflavine / Q000494:pharmacology; D003030:Coagulase / Q000096:biosynthesis*; D003864:Depression, Chemical; D013045:Species Specificity; D013211:Staphylococcus aureus / Q000187:drug effects* / Q000201:enzymology
D000166:Acridines; D003030:Coagulase; D000167:Acriflavine
Produktsiia vnekletochnoĭ plazmokoagulazy u zolotistykh stafilokokkov v usloviiakh vozdeĭstviia 3,6-diaminoakridinami