title: Probabilities of transversions and transitions.
abstract: The values of the mean relative probabilities of transversions and transitions have been refined on the basis of the data collected by Jukes and found to be equal to 0.34 and 0.66, respectively. Evolutionary factors increase the probability of transversions to 0.44. The relative probabilities of individual substitutions have been determined, and a detailed classification of the nonsense mutations has been given. Such mutations are especially probable in the UGG (Trp) codon. The highest probability of AG, GA transitions correlates with the lowest mean change in the hydrophobic nature of the amino acids coded.
mesh_terms: D000596:Amino Acids; D005075:Biological Evolution; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D003062:Codon; D004261:DNA Replication; D005815:Genetic Code; D005914:Globins; D008954:Models, Biological; D009154:Mutation; D011336:Probability; D012333:RNA, Messenger
chemical_list: D000596:Amino Acids; D003062:Codon; D012333:RNA, Messenger; D005914:Globins