De Lange syndrome. Clinical, dermatoglyphic and chromosomal findings in nine cases.
Nine cases of the de Lange syndrome are reviewed. Our findings show that the facial characteristics in the present series and in previously reported cases are remarkably similar. Dermatoglyphically, we have documented an increased incidence of tibial loops on the hallucal area and increased incidence of single flexion creases of the digits from this study series. Our study also supports the previous authors who have recorded an increased incidence in radial loops on the second and third digits and increased incidence of simian lines. We have not been able to document a consistent chromosomal defect.
D002675:Child, Preschool; D002902:Chromosomes, Human, 16-18; D003635:De Lange Syndrome / Q000235:genetics*; D003878:Dermatoglyphics; D004480:Ectromelia / Q000235:genetics; D005260:Female; D006801:Humans; D008297:Male; D014314:Trisomy