Effect of ionizing radiation on liver microcirculation and oxygenation.
Platelet aggregation and adhesiveness, as well as TPO2 responses to hypoxia were measured as microcirculation parameters in beagle dogs subject to Co60 ionizing radiation to a dose of 4600 rads in 5 weeks. Simultaneously, changes in blood chemistry and coagulation were also determined. Marked changes in all studied parameters in the post radiation period lead to the conclusion that radiation liver damage is at least in part mediated through microcirculation disturbances.
D000818:Animals; D004285:Dogs; D005260:Female; D005947:Glucose / Q000378:metabolism; D008099:Liver / Q000098:blood supply / Q000378:metabolism / Q000528:radiation effects*; D008833:Microcirculation / Q000528:radiation effects*; D010100:Oxygen / Q000097:blood; D010101:Oxygen Consumption / Q000528:radiation effects; D010973:Platelet Adhesiveness / Q000528:radiation effects; D010974:Platelet Aggregation / Q000528:radiation effects; D011839:Radiation, Ionizing
D005947:Glucose; D010100:Oxygen