Differentiation of host-mediated antitumor agents from mitotic posons by the antitumor foot-pad reaction in Ehrlich carcinoma-ddY mouse system.
The effect of antitumor agents (lentinan, PS-K, Mitomycin-C, 6-mercaptopurine, etc.) on the antitumor delayed hypersensitivity reaction (DHR) measured by the foot-pad test was compared with their effect on tumor growth in ddY mice with Ehrlich tumor. These agents all inhibited growth of Ehrlich carcinoma. Lentianan and PS-K enhanced the antitumor DHR, but Mitomycin-C and 6-mercaptopurine did not. By plotting the effect of agents on the anti-tumor DHR against these effects on tumor weight, host-mediated antitumor agents could be differentiated from mitotic poisons. Attempts to distinguish these two types of agents by the same method using a syngeneic tumor system were unsuccessful.
D000818:Animals; D000970:Antineoplastic Agents / Q000145:classification* / Q000494:pharmacology; D002286:Carcinoma, Ehrlich Tumor / Q000188:drug therapy / Q000276:immunology*; D005528:Foot; D007109:Immunity / Q000187:drug effects*; D007912:Lentinan / Q000627:therapeutic use; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D008937:Mitomycins / Q000145:classification / Q000627:therapeutic use; D008938:Mitosis / Q000187:drug effects; D011134:Polysaccharides / Q000145:classification
D000970:Antineoplastic Agents; D008937:Mitomycins; D011134:Polysaccharides; D007912:Lentinan