Experimental gastric ulcers in the fundic gland area following transplantation of the gastric-wall pedicles.
Using adult mongrel dogs, a portion of the anterior gastric wall of the pyloric gland area was transplanted into the fundic gland area using the Z-plastic procedure forming an islet. Three weeks postoperatively, 2 per cent histamine in sesame oil was injected intramuscularly in a daily dose of 2 mg/kg body weight. Ulcers developed in the graft in nine of 19 animals. The factors responsible to the development of the ulcers may well be circulatory disturbance and reduction of mucosal resistance following surgical insult, and continuous irritation caused by gastric juice. When a portion of the anterior gastric wall of the fundic gland area was transplanted into the fundic gland area followed by administration of histamine in sesame oil, ulcers developed in the graft only in four of 12 animals. Histological examination revealed the regenerated epithelium at the margin of the ulcers. Thus the ulcers presently induced may provide an useful experimental model for ulcers in the fundic gland area.
D000818:Animals; D004195:Disease Models, Animal; D004285:Dogs; D005260:Female; D006632:Histamine / Q000008:administration & dosage; D006801:Humans; D008297:Male; D011708:Pylorus / Q000637:transplantation; D012715:Sesame Oil / Q000008:administration & dosage; D013270:Stomach / Q000637:transplantation*; D013276:Stomach Ulcer / Q000209:etiology* / Q000473:pathology; D014182:Transplantation, Autologous
D012715:Sesame Oil; D006632:Histamine