Release of platelet 5-hydroxytryptamine by plasma taken from patients during and between migraine attacks.
Experiments were carried out in order to further delineate the pathophysiology of the fall of plasma 5-hydroxytryptamine (5-HT) during a migraine attack. Platelets from normal subjects were incubated with 14C-labelled 5-HT, and the release of 5-HT was measured following exposure of these platelets to plasma taken from migraine patients during an attack or at headache-free intervals. Plasma taken during attacks released significantly more 5-HT. It is concluded that factor(s) exist in the serum during migraine attacks, which can cause 5-HT release from normal platelets. The identification of this factor may be important.
D001792:Blood Platelets / Q000378:metabolism*; D005260:Female; D006801:Humans; D008297:Male; D008881:Migraine Disorders / Q000097:blood*; D012701:Serotonin / Q000097:blood*
D012701:Serotonin