title: Chronobiology in the diagnosis and treatment of mesor-hypertension.
abstract: An elevation of systolic and diastolic bloodpressure to values regarded as abnormal ones on the basis of conventional criteria was recognized by self-measurement. For both systolic and diastolic blood pressure, the overall means adjusted for rhythms, the so-called mesors, also were elevated in the light of their response to treatment: these mesors were found to be lowered with statistical significance when values during treatment were compared by an objective test with values measured before treatment. Individualized rhythmometry quantitatively characterizes a predictalbe portion of the variability in human blood pressure and tests for the statistical significance of changes in blood pressure as a function of the treatment and also as a function of the  circadian timing of such treatment. The case report thus illustrates an individualized chronotherapy of systolic and diastolic mesor-hypertension, diagnosed retrospectively from the tested effect of hydrochlorothiazide. In the case reported, and perhaps routinely, computer-analyzed self-measurements can serve 1) to prescribe the right kind and amount with the right timing, for a given therapy, and 2) for diagnosis and prevention as well (Meyer et al.; Halberg et al.).
mesh_terms: D001794:Blood Pressure; D002940:Circadian Rhythm; D004032:Diet; D004039:Diet, Sodium-Restricted; D006801:Humans; D006852:Hydrochlorothiazide / Q000627:therapeutic use; D006973:Hypertension / Q000175:diagnosis* / Q000178:diet therapy / Q000628:therapy; D008297:Male; D008433:Mathematics; D008875:Middle Aged; D012965:Sodium Chloride
chemical_list: D006852:Hydrochlorothiazide; D012965:Sodium Chloride