title: On the relationship between the activity of acetylation, growth of experimental tumors and efficacy of their suppression by hydrazine sulphate.
abstract: The growth of experimental tumors was found to involve an intensification of acetylation of sulphadimidine. Inhibition of carcinosarcoma Walker-256 by 88% and sarcoma-180 by 36% on treatment with 60 mg/kg body weight of hydrazine sulphate was followed by decreases in the rate of acetylation of 39.4 and 29.4%, respectively. When treatment failed to suppress tumor growth (sarcoma-45), acetylation level showed no decrease. The results point to a correlation between growth of tumors and their inhibition on the one hand and the level of acetylation on the other.
mesh_terms: D000107:Acetylation; D000123:Acetyltransferases / Q000378:metabolism*; D000818:Animals; D002279:Carcinoma 256, Walker / Q000188:drug therapy / Q000201:enzymology / Q000378:metabolism*; D005260:Female; D006834:Hydrazines / Q000627:therapeutic use*; D051379:Mice; D009368:Neoplasm Transplantation; D051381:Rats; D013418:Sulfamethazine / Q000378:metabolism; D014184:Transplantation, Homologous
chemical_list: D006834:Hydrazines; D013418:Sulfamethazine; D000123:Acetyltransferases