title: [Bone metabolic disorders after prolonged treatment with antiepileptic agents in a patient with idiopathic hypoparathyroidism].
abstract: A case is reported of a patient, aged 20, with idiopathic hypoparathyroidism, manifested with the picture of epilepsy with a long treatment with antiepileptic remedies. Two years after the initiation of the antiepilertic treatment, severe skeleton disturbances occurred with manifested osteoporosis and multiple symmetric zones of bone reconstruction, hypocalcemia, hyperphosphatemia and elevated serum alkaline phosphatase. The disturbances of calcium and phosphorus level in blood are favourably affected by the application of relatively high vitamin D doses. The role of the long-term anticonvulsive treatment in the development of vitamin D resistant rickets and osteomalacia is discussed.
mesh_terms: D000328:Adult; D000927:Anticonvulsants / Q000009:adverse effects*; D001842:Bone and Bones / Q000187:drug effects* / Q000378:metabolism; D004359:Drug Therapy, Combination; D004827:Epilepsy / Q000188:drug therapy* / Q000378:metabolism; D006801:Humans; D007011:Hypoparathyroidism / Q000188:drug therapy* / Q000378:metabolism; D008297:Male; D008659:Metabolic Diseases / Q000139:chemically induced*; D013997:Time Factors
chemical_list: D000927:Anticonvulsants
vernacular_title: Narusheniia v kostniia metabolizum sled produlzhitelno lechenie s protivoepileptichni sredstva pri bolen s idiopatichen khipoparatireoidizum