[Morphofunctional characteristics of the adrenal glands in the progeny from females with experimental hypothyroidism].
Under study were the morphofunctional features of adrenal glands of 1, 10, 20, 30 and 40-day-old rats born by females with experimental hypothyrosis obtained by bilateral subtotal parathyroidectomy and blocade of the gland functioning by mercazolil (3 mkg/kg). The experimental treatment preceded pregnancy. The antithyroid drug was injected during pregnancy and lactation. The posterity of experimental animals was established to have a decreased need in oxygen as compared with controls. Their adrenal glands were of less weight (especially in off-springs of parathryodidectomized rats in the neonatal period). There are a number of morphometrical and histochemical signs suggesting the suppression of the functioning of the cortical and medullary substance, including the period of adaptation of the organism to the extrauterine life.
D000302:Adrenal Cortex / Q000254:growth & development; D000311:Adrenal Glands / Q000196:embryology*; D000313:Adrenal Medulla / Q000254:growth & development; D000818:Animals; D005260:Female; D005865:Gestational Age; D007037:Hypothyroidism / Q000503:physiopathology*; D009929:Organ Size; D011247:Pregnancy; D051381:Rats
O morfofunktsional'nykh osobennostiakh madpochechnykh zhelez potomstva ot samok s éksperimental'nym gipotireozom.