[Change in the adrenocortical function of the adrenals and activity of several intracellular enzymes involved in nitrogen metabolism in experimental hypothermia].
An increased content of adrenaline was observed in rabbit adrenal glands under the conditions leading to a decrease of rectal temperature. At the same time the activities of aspartate- and alanine aminotransferases in liver hyaloplasm and ornithine carbamoyl-transferase in mitochondria were decreased, while the activity of the transaminases in mitochondria was maintained unaltered. After the recovery of the temperature the content of the hormone still exceeded the normal level; function of the enzymes studied was distinctly intensified in all the subcellular fractions of hepatocyte. Content of 11-hydrocorticosteroid, being unaltered distinctly in overcooling, was markedly decreased within the later period. Membrane and substrate interrelations, apparently responsible for the biochemical alterations observed, are discussed.
D015062:11-Hydroxycorticosteroids / Q000378:metabolism; D000302:Adrenal Cortex / Q000378:metabolism*; D000311:Adrenal Glands / Q000378:metabolism*; D000410:Alanine Transaminase / Q000378:metabolism; D000818:Animals; D001219:Aspartate Aminotransferases / Q000378:metabolism; D002682:Chinchilla; D004837:Epinephrine / Q000378:metabolism; D007035:Hypothermia / Q000201:enzymology / Q000378:metabolism*; D008099:Liver / Q000201:enzymology*; D008930:Mitochondria, Liver / Q000201:enzymology; D009954:Ornithine Carbamoyltransferase / Q000378:metabolism
D015062:11-Hydroxycorticosteroids; D009954:Ornithine Carbamoyltransferase; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase; D004837:Epinephrine
Izmenenie adrenokortikal'noĭ funktsii nadpochechnikov i aktivnosti nekotorykh vnutrikletochnykh fermentov azotistogo metabolizma pri éksperimental'noĭ gipotermii