[Increase in the sensitivity of rabbit sensomotor cortex neurons to gamma-aminobutyric acid under the influence of diazepam (microiontophoretic study)].
A study was made of the action of diazepam on the effects of the gamma-aminobutyric acid (GABA) applied electrophoretically to the neurons of the sensory-motor rabbit cortex. It was shown that diazepam intensified the depressive action of GABA on the spontaneous neuronal activity and the prolonging action of GABA on the duration of the inhibitory phase in the neuron responses to the afferent and direct stimulation of the cortex. Diazepam failed to alter the neuron response to glycine, glutamate and acetylcholine applied microelectrophoretically. It is supposed that diazepam increased the sensitivity of the receptors of the post-synaptic membrane of the neuron to GABA.
D000613:Aminobutyrates / Q000494:pharmacology*; D000818:Animals; D003864:Depression, Chemical; D003975:Diazepam / Q000494:pharmacology*; D004357:Drug Synergism; D007478:Iontophoresis; D009044:Motor Cortex / Q000187:drug effects*; D011817:Rabbits; D013003:Somatosensory Cortex / Q000187:drug effects*; D005680:gamma-Aminobutyric Acid / Q000494:pharmacology*
D000613:Aminobutyrates; D005680:gamma-Aminobutyric Acid; D003975:Diazepam
Povyshenie chuvstvitel'nos ti neĭronov sensomotornoĭ kory k gamma-aminonaslianoĭ kislote pod vliianiem diazepama (mikroionoforeticheskoe issledovanie)