[Differential changes in serum levels of N-acetylneuramic acid and L-fucose as manifestations of physiological and physiopathological adaptation in man. Pregnancy as an experimental model. The tumoral, vascular and hepatic diseases as possible pathological models].
In this paper we report on the modifications that normal pregnancy introduces on the blood maternal serum concentrations of both N-acetyl maternal serum concentrations of both N-acetyl-neuraminic acid which is elevated above normal level and L-fucose which on the contrary is diminished. The experiences were performed with women in the last trimester of normal gestations. The probable physiochemical meaning and biological significance of those such changes are discussed in connection both to the maternal physiological adaptation during pregnancy and to the possible metabolical changes in intracellular regulation that might take place in such a situation. Similarly it is emphasized the probability that numerous pathological conditions including malignancy vascular diseases and hepatic disorders which course with overt changes in plasma glucoproteins might be amenable to present notorious modifications in N-acetylneuraminic acid and L-fucose plasmatic levels.
D000222:Adaptation, Physiological; D000328:Adult; D005260:Female; D005643:Fucose / Q000097:blood*; D006801:Humans; D008107:Liver Diseases / Q000097:blood*; D009369:Neoplasms / Q000097:blood*; D011247:Pregnancy; D011263:Pregnancy Trimester, Third; D012794:Sialic Acids / Q000097:blood*; D014652:Vascular Diseases / Q000097:blood*
D012794:Sialic Acids; D005643:Fucose
Cambios diferenciales en los niveles séricos del acido N-acetilneuramínico y de la L-fucosa como manifestaciones de adaptación fisiológica y fisiopatológica en el humano. La gestación como modelo experimental. Los padecimientos tumorales, vasculares y hepáticos como posibles modelos patológicos