[Pulmonary hemodynamics, coagulation and morphological changes in the lung after thrombocyte aggregation inhibition and intravasal coagulation in experimental trauma and hemorrhagic shock].
26 mongrel dogs are subjected to a standardized bone trauma followed by a hypotonic hemorrhagic shock. Compared with a control and heparin group prophylactic treatment with Dipyridamol and Acetylsalicylic Acid decreases pulmonary vascular resistance significantly. After an initial period of hyperocagulability secondary fibrinolysis develops. The decrease of the fibrinogen level and the fall of total platelet count after trauma and hemorrhage can partly be prevented by the application of heparin, likewise the development of pulmonary microthrombosis. Histological examination shows a markedly diminished pulmonary microthrombosis.
D000403:Airway Resistance / Q000187:drug effects; D000818:Animals; D001241:Aspirin / Q000494:pharmacology; D004176:Dipyridamole / Q000494:pharmacology; D004285:Dogs; D006439:Hemodynamics / Q000187:drug effects*; D008168:Lung / Q000166:cytology / Q000503:physiopathology*; D010974:Platelet Aggregation / Q000187:drug effects*; D012771:Shock, Hemorrhagic / Q000097:blood / Q000503:physiopathology*; D014947:Wounds and Injuries / Q000150:complications*
D004176:Dipyridamole; D001241:Aspirin
Pulmonale Hämodynamik, Gerinnung und morphologische Veränderungen in der Lunge nach Hemmung der Thrombocytenaggregation und intravasalen Gerinnung bei experimentellem Trauma und hämorrhagischem Schock.