Review of 1,375 cases of vascular reconstruction for ischemic disorder of the lower limbs Statistical analysis of late postoperative thromboses with evaluation of the effect of an anti-platelet agent[tauthor's transl)].
The authors are presenting 1.375 cases of arterial reconstruciton of the lower limbs, those patients having undergone 1.562 operatons between 1963 and 1974. Although mention is made of long-term postoperative morbidity (false femoral aneurysm, infection, amputation), the study is mainly centered on the problem of late thromboses, calculated in percentages per year and classified according to the time lapse since the initail operation. Comparison is made between the percentages before and after 1972. Since 1972, Dipyridamol, an anti-platelet agent, has been administered systematically to all vascular reconstructions of the lower limbs. The action of this type of drug on the platelet adhesivenss is briefly treated. In this respect the numbers calculated suggests a decrease of about 25 % in the numbers of late thrombosis, all other treatment remaining unchanged for the past 11 years. In conclusion, operative indication and surgical skill remain primordial in this type of surgery. However, the anti-platelet treatment, associated with fat-free diet, no tobacco, vasodilators or anticoagulants, seems to bring a further guarantee to permeability of arterial reconstructions.
D001162:Arteriosclerosis Obliterans / Q000601:surgery*; D004176:Dipyridamole / Q000627:therapeutic use*; D005500:Follow-Up Studies; D006801:Humans; D007866:Leg / Q000098:blood supply*; D008875:Middle Aged; D010973:Platelet Adhesiveness / Q000187:drug effects; D013927:Thrombosis / Q000517:prevention & control*
D004176:Dipyridamole
Réflexions et commentaires concernant 1.375 cas de reconstruction vasculaire pour troubles ischémiques des membres inférieurs. Analyse statistique des thromboses tardives avec évaluation de l'effet d'un agent antiplaquettaire