[H1- and H2-receptor sensitivity to 3-(beta-aminoethyl)-1,2,4-triazole derivatives].
Histamine-like derivatives of 3-(beta-aminoethyl)-1,2,4-trizole were synthetized and subjected to a pharmacological study. The sensitivity of H1- and H2-receptors to these substances was defined by the following tests, viz. in the isolated uterus of a rat, on the isolated atrium of a guinea pig and measurements of the blood pressure nn a cat. The derivative 3-(beta-aminoethyl)-5-amino-1,2,4-triazole (IEM-813) affects predominantly H1-receptors, while 3-(aminoethyl)-5-amino-1,2,4,triazole (IEM-759) has the closest affinity for H2-receptors, The authors presume that corresponding zones of histamine recpetors differ in their lyophilic and hydrophilic properties.
D000640:Amitrole / Q000031:analogs & derivatives / Q000494:pharmacology*; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D004285:Dogs; D005260:Female; D005750:Gastric Juice / Q000378:metabolism; D005753:Gastric Mucosa / Q000187:drug effects; D006168:Guinea Pigs; D006325:Heart Atria / Q000187:drug effects; D007422:Intestines / Q000187:drug effects; D008297:Male; D051381:Rats; D011968:Receptors, Histamine / Q000187:drug effects*; D011969:Receptors, Histamine H1 / Q000187:drug effects*; D011970:Receptors, Histamine H2 / Q000187:drug effects; D014230:Triazoles / Q000494:pharmacology*; D014599:Uterus / Q000187:drug effects
D011968:Receptors, Histamine; D011969:Receptors, Histamine H1; D011970:Receptors, Histamine H2; D014230:Triazoles; D000640:Amitrole
Chuvstvitel'nost' H1- i H2-retseptorov gistamina k proizvodnym 3-(beta-minoetil)-1,2,4-triazola.