Morphine withdrawal reactions in male and female mice.
In the present study we have used the morphine implantation method to investigate the intensity of the abstinence syndrome in both male and female Swiss Webster morphine-dependent mice. It is evident from our data that naloxone induced no significant difference in the jumping behavior of both morphine-dependent male and female mice when weight variables were controlled.
D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects; D004343:Drug Implants; D005260:Female; D006801:Humans; D008297:Male; D051379:Mice; D009020:Morphine / Q000008:administration & dosage; D009021:Morphine Dependence / Q000503:physiopathology*; D009270:Naloxone / Q000494:pharmacology; D012737:Sex Factors; D013375:Substance Withdrawal Syndrome / Q000139:chemically induced / Q000503:physiopathology*
D004343:Drug Implants; D009270:Naloxone; D009020:Morphine