Altered response in vitro of the human umbilical artery to sera of neonates with respiratory distress syndrome and other hypoxic conditions.
A study was made of the reaction of the human umbilical artery and the isolated rabbit auricular artery to protein-free ultrafiltrates of normal and hypoxic sera originating from neonates suffering from RDS or other acute metabolic disturbances. While a normal serum ultrafiltrate caused an enhanced contraction of the umbilical artery, hypoxic sera exerted a weaker pressor activity. At the same time, on the rabbit's isolated auricular artery the hypoxic sera exhibited a higher pressor activity. The phenomenon is in agreement with the clinical observation that spontaneous closure of the umbilical vessels is delayed in the case of fetal hypoxia.
D000818:Animals; D002648:Child; D006801:Humans; D000860:Hypoxia / Q000097:blood*; D007223:Infant; D007231:Infant, Newborn; D009130:Muscle, Smooth / Q000503:physiopathology*; D011817:Rabbits; D012127:Respiratory Distress Syndrome, Newborn / Q000097:blood*; D014462:Ultrafiltration; D014469:Umbilical Arteries / Q000503:physiopathology; D014655:Vascular Resistance; D014662:Vasoconstrictor Agents / Q000097:blood
D014662:Vasoconstrictor Agents