[Process of bile formation and bile composition in albino rats in acute adrenal cortex insufficiency and adrenal gland autologous transplantation].
Experiments were conducted on 84 male albino rats. A study was made of the state of the bile forming process 7, 14 and 30 days after bilateral adrenalectomy and adrenal gland autotransplantation. Investigations carried out showed inhibition of the bile formation with the corresponding changes in the chemical composition of bile to occur both in adrenalectomized animals and the rats with adrenal autotransplantation; in the second case, however, these changes were less pronounced. A gradual suppression of the intensity of bile production, cholate formation, bilirubin- and cholesterol secretion occurred in the adrenalectomized rats, whereas in the animals a significant shift in the direction of restoration took place as soon as in 7 days after autotransplantation. The first to become restored is the cholesterin secretory function in the liver, then the intensity of the cholate formation, particularly the glycocholic and desoxycholic acids, and bilirubin secretion. The intensity of bile secretion, as well as the sum total content of cholates in the bile, chiefly on account of taurocholic acid, failed to reach the initial level even by the 30th day after the adrenal gland autotransplantation.
D000208:Acute Disease; D000302:Adrenal Cortex / Q000378:metabolism; D000311:Adrenal Glands / Q000637:transplantation*; D000309:Adrenal Insufficiency / Q000378:metabolism*; D000315:Adrenalectomy; D000818:Animals; D001646:Bile / Q000032:analysis / Q000378:metabolism; D001647:Bile Acids and Salts / Q000032:analysis; D001663:Bilirubin / Q000032:analysis; D002784:Cholesterol / Q000032:analysis; D008297:Male; D051381:Rats; D014182:Transplantation, Autologous
D001647:Bile Acids and Salts; D002784:Cholesterol; D001663:Bilirubin
Protsess zhelcheobrazovaniia i sostav zhelchi u belykh krys pri ostroi korkovo-nadpochechnikovoĭ nedostatochnosti i auto transplantatsii nadpochechnikov