Transmural gradients in ischemic canine left ventricle: effects of blood reflow on glycolytic intermediates.
Following two and four hours of left ventricular ischemia, 20 minutes of blood reflow cannot produce a complete return to normal oxidative metabolism in ischemic canine myocardium. Glycolysis remains increased and aerobic metabolism is most extensively depressed in the subendocardium.
D000818:Animals; D003326:Coronary Circulation; D003327:Coronary Disease / Q000378:metabolism*; D004285:Dogs; D005958:Glucosephosphates / Q000378:metabolism; D006019:Glycolysis; D006352:Heart Ventricles / Q000378:metabolism; D007700:Kinetics; D007773:Lactates / Q000378:metabolism; D009206:Myocardium / Q000378:metabolism*; D013997:Time Factors
D005958:Glucosephosphates; D007773:Lactates