title: [Synthesis and biological activity of the decapeptide Gly-Pro-Cys-Lys-Ala-Arg-Phe-Gly-Gly-Cys as a model for the active center of the basic trypsin inhibitor from bovine organs (Kunitz inhibitor) (author's transl)].
abstract: The synthesis of the above mentioned decapeptide as a model for the active center of the inhibitor molecule is described. The Ki value of this peptide was found to be 4.7 X 10(-4)M. This Ki value differs from the Ki value of the Kunitz Inhibitor by a factor of 10(10).
mesh_terms: D000818:Animals; D002417:Cattle; D008722:Methods; D008954:Models, Biological; D010455:Peptides / Q000032:analysis / Q000138:chemical synthesis / Q000494:pharmacology; D014360:Trypsin Inhibitor, Kunitz Soybean / Q000494:pharmacology*; D014361:Trypsin Inhibitors / Q000494:pharmacology*
chemical_list: D010455:Peptides; D014361:Trypsin Inhibitors; D014360:Trypsin Inhibitor, Kunitz Soybean
vernacular_title: Synthese und biologische Aktivität des Dekapeptids Gly-Pro-Cys-Lys-Ala-Arg-Phe-Gly-Gly-Cys als Modell für das aktive Zentrum des basischen Trypsininhibitors aus Rinderorganen (Kunitz-Inhibitor