[Hypotensive effect and toxicity of octadin and papaverine following their combined administration].
A study on the hypotensive action of combined injections of papaverine and octadine (guanethidine) was carried out in acute experiments on 90 anaesthetized cats. It was shown that with combined injections of octadine (in doses exceeding by 22% ED100) and of papaverine (in doses inferior by 22% to ED100) the hypotensive action was potentiated. A change of the said proportions led to a diminished hypotensive effect. It was also found that the most effective combinations of the 2 drugs was the one consisting of 0.5 mg/kg of papaverine and 5 mg/kg of octadine (in a ratio of 1:10). By studying the toxicity of the 2 drugs and of their combinations on 350 albino mice it was ascertained that their toxicity diminished if the drugs were used together.
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects*; D002415:Cats; D004357:Drug Synergism; D006145:Guanethidine / Q000008:administration & dosage* / Q000494:pharmacology / Q000633:toxicity; D007275:Injections, Intravenous; D051379:Mice; D010208:Papaverine / Q000008:administration & dosage* / Q000494:pharmacology / Q000633:toxicity
D010208:Papaverine; D006145:Guanethidine
Gipotensivnoe deĭstvie i tiksichnost' oktadina i papaverina pri ikh kombinirovannom vvedenii