[Mass-spectrometric study of the mechanism of microbial oxidation of 3-pyridinaldehyde].
In order to clarify mechanisms of nicotinic acid synthesis during microbial transformation of 3-methylpyridine, microbial and spontaneous air oxygen oxidation of 3-pyridinaldehyde to nicotinic acid in the H218O environment was studied. It was shown that during spontaneous oxidation the label was incorporated into one atom of oxygen in the carboxylic group of nicotinic acid. During the microbial oxidation the label was equally incorporated into both atoms of oxygen in the carboxylic group of nicotinic acid. It is concluded that the mechanisms of spontaneous and microbial oxidation of 3-pyridinaldehyde are different. It is suggested that the possible precursor of nicotinic acid during microbial oxidation may be hydroxy-3-pyridinaldehyde.
D000447:Aldehydes / Q000378:metabolism*; D003470:Culture Media; D007553:Isotope Labeling; D007554:Isotopes; D013058:Mass Spectrometry; D009539:Nicotinic Acids / Q000032:analysis / Q000096:biosynthesis; D009615:Nocardia / Q000378:metabolism*; D010084:Oxidation-Reduction; D010100:Oxygen; D011725:Pyridines / Q000378:metabolism*
D000447:Aldehydes; D003470:Culture Media; D007554:Isotopes; D009539:Nicotinic Acids; D011725:Pyridines; C014785:3-pyridinaldehyde; D010100:Oxygen
Mass-spektrometricheskoe izuchenie mekhanizma mikrobiologicheskogo okisleniia 3-piridinal'degida