[Polysaccharide biological activity dependent on structural characteristics].
Anti-Influenza and interferonogenic activity of polysaccharides from the glucane class produced extracellularly by the yeast-like organism Aureobasidium pollulans was studied on albino mice. The polysaccharides differed from each other by the branching level and content of bonds beta-C1-C3 and alpha-C1-C between the monomers. At the moment of the drugs administration to the albino mice the level of the early interferon was in correlation with the following 2 factors: the level of the polysaccharide branching and the percentage of bonds beta-C1-C3, while the amount of interferon produced in 24 hours correlated only with the percentage of bonds beta-C1-C4. The anti-influenza activity of the polysaccharides depended on the level of interferon production induced by them in the mice. Preparations stimulating production of sufficient amounts of both early and later interferon had the maximum activity.
D000818:Animals; D000998:Antiviral Agents; D009980:Influenza A virus / Q000187:drug effects; D007369:Interferon Inducers; D007372:Interferons / Q000097:blood; D051379:Mice; D003904:Mitosporic Fungi; D011134:Polysaccharides / Q000032:analysis / Q000494:pharmacology*; D013329:Structure-Activity Relationship; D013997:Time Factors
D000998:Antiviral Agents; D007369:Interferon Inducers; D011134:Polysaccharides; D007372:Interferons
Biologicheskaia aktivnost' polisakharidov v zavisimosti ot ikh strukturnykh osobennosteĭ