Bioavailability of digoxin and beta-methyl-digoxin.
In a randomized crossover study the bioavailability of a single dose of digoxin and of beta-methyl-digoxin tablets was tested in four normal volunteers. No difference was found between the two products in the rate and extent of drug absorption using 6 day cumulative urinary excretion and serial serum concentration measurements.
D000328:Adult; D001682:Biological Availability; D004077:Digoxin / Q000031:analogs & derivatives* / Q000378:metabolism*; D005260:Female; D006801:Humans; D007408:Intestinal Absorption; D008297:Male; D008875:Middle Aged; D013329:Structure-Activity Relationship; D013997:Time Factors
D004077:Digoxin