title: [Age-specific characteristics of functional disorders of the cardiovascular system and respiration in experimental atherosclerosis].
abstract: Results of investigations into age-specific peculiarities inherent in the contractile function of the cardiac ventricular myocardium, hemodynamics of the lesser circulation, oxygen supply of the organism in young (6--12 months old) and old (3 1/2--4 1/2 year old) rabbits in normalcy and with experimental atherosclerosis are reported. The contractility of the left ventricle myocardium in old animals was down as compared to the normal in young ones. Induction of atherosclerosis impairs this important function of the myocardium to a still greater degree. In old animals hemodynamics of the lesser circulation is characterized by a rising systolic pressure in the right ventricle and of the tension-time index (TTI) as contrasted against the young one in normalcy and with atherosclerosis. Against this background an additional action on the organism is attended by more pronounced pathological manifestations, i.e. in reactions of the cardiovascular system (including the lesser circulation). The initial manifestations of hypoxia recorded in older animals, as compared to the younger ones in normality, become more intensive in cases of induced atherosclerosis. There is reduced consumption of oxygen, oxygen saturation of arterial and, especially, mixed venous blood, as well as oxygen tension in the arterial blood. The recorded changes are of significance in clarifying the caused and conditions conducive to the development of atherosclerosis and to the intensification of its manifestations in an old organism.
mesh_terms: D000367:Age Factors; D000818:Animals; D001161:Arteriosclerosis / Q000209:etiology / Q000503:physiopathology*; D006321:Heart / Q000503:physiopathology*; D006439:Hemodynamics; D000860:Hypoxia / Q000150:complications; D008168:Lung / Q000503:physiopathology*; D010100:Oxygen / Q000097:blood; D010101:Oxygen Consumption; D011817:Rabbits; D012119:Respiration
chemical_list: D010100:Oxygen
vernacular_title: Vozrastnye osobennosti natusheniĭ funktsii serdechno-sosudistoĭ sistemy i dykhaniia pri eksperimental'nom ateroskleroze