Studies on antilipolytic activity of antipyretics. Part II. Influence of sodium salicylate, aminophenazone, and acetophenidin on lipolysis stimulated by noradrenaline and aminophylline in vitro.
Lipolysis, expressed as muEq of FFA released from 1 g of epidydymal fat tissue per hour, was stimulated by noradrenaline (NA) and aminophyline. Sodium salicylate inhibited the lipolysis stimulated by NA, but not by aminophylline. Aminophenazone and acetophenidin inhibited the lipolysis stimulated either by NA or by aminophylline. The antipyretics inhibited stimulated lipolysis in a non-competitive manner. The results suggest an important role of the action of antipyretics on lipolysis in their hypothermizing action.
D000628:Aminophylline / Q000494:pharmacology*; D000632:Aminopyrine / Q000494:pharmacology; D000700:Analgesics / Q000494:pharmacology*; D000818:Animals; D004347:Drug Interactions; D005230:Fatty Acids, Nonesterified / Q000378:metabolism; D066298:In Vitro Techniques; D050356:Lipid Metabolism; D008297:Male; D009638:Norepinephrine / Q000494:pharmacology*; D010615:Phenacetin / Q000494:pharmacology; D051381:Rats; D012980:Sodium Salicylate / Q000494:pharmacology; D013268:Stimulation, Chemical
D000700:Analgesics; D005230:Fatty Acids, Nonesterified; D000632:Aminopyrine; D000628:Aminophylline; D010615:Phenacetin; D012980:Sodium Salicylate; D009638:Norepinephrine