title: Porcine malignant hyperthemia IV: Neuromuscular blockade.
abstract: The effect of tubocurarine and pancuronium on the initiation or prevention of porcine malignant hyperthermia (MH) was investigated in Pietrain pigs. Tubocurarine 0.6 mg/kg body weight inhibited a suxamethonium-induced response in three pigs, but failed to prevent a fatal halothane-induced response in a further four pigs. Pancuronium 0.2 mg/kg body weight was given to six pigs before a halothane challenge. Three animals developed MH and died; the remainder succembed only after reversal of the neuromuscular blockade. The partial protection afforded by large doses of pancuronium is discussed in relation to the ability of previous muscle activity to influence the sensitivity to halothane.
mesh_terms: D000818:Animals; D006221:Halothane; D008305:Malignant Hyperthermia / Q000188:drug therapy* / Q000209:etiology; D009469:Neuromuscular Junction / Q000187:drug effects; D010197:Pancuronium / Q000627:therapeutic use*; D013390:Succinylcholine; D013552:Swine; D013997:Time Factors; D014403:Tubocurarine / Q000627:therapeutic use*
chemical_list: D013390:Succinylcholine; D010197:Pancuronium; D006221:Halothane; D014403:Tubocurarine