Preferential acid-catalyzed hydrolysis of the formamide linkage of N'-formylkynurenine in frozen solution.
Acid-catalyzed hydrolysis of the formamide linkage of N-acetyl-N'-formyl-L-kynurenineamide in frozen dilute hydrochloric acid solution followed first-order kinetics, yielding N-acetyl-L-kynurenineamide as the sole reaction product. The maximum rate of reaction in the frozen solution was found at around -7.5 degrees and approximated that of the reaction in liquid solution at 40 degrees. By freezing the dilute acid solution at -8 degrees the reaction was accelerated by 60 times compared with that in super-cooled liquid solution at the same temperature.
D005559:Formamides; D005615:Freezing; D006851:Hydrochloric Acid; D006868:Hydrolysis; D007700:Kinetics; D007737:Kynurenine / Q000031:analogs & derivatives*
D005559:Formamides; D007737:Kynurenine; D006851:Hydrochloric Acid