Effects of lesions of monoaminergic system in the brain on the hypotensive effects of clonidine in rats.
Bilateral lesions of the locus coeruleus markedly reduced hypotensive effects of clonidine in rats. Lesions shifted laterally did not evoke any significant change of the hypotensive effects of clonidine or bradycardia induced by it. Lesions of the ventral and dorsal noradrenergic tract at the midbrain level and lesions of the midbrain raphe area failed to change hypotensive response to clonidine.
D000818:Animals; D001679:Biogenic Amines / Q000502:physiology*; D001794:Blood Pressure / Q000187:drug effects*; D001921:Brain / Q000502:physiology*; D002552:Cerebral Ventricles / Q000502:physiology; D003000:Clonidine / Q000494:pharmacology*; D003864:Depression, Chemical; D008297:Male; D051381:Rats
D001679:Biogenic Amines; D003000:Clonidine