[Central activity, antihypertensive action and antiulcerogenic effects of neurotropin].
Central activity, antihypertensive action and antiulcerogenic actions of Neurotropin (NSP), an extract isolated from vaccinia virus-innoculated skin or tissues of rabbits were investigated herein. When actions of NSP were examined in isolated muscle preparations by the Magnus-method, peristalsis and ACh-induced contraction in the small intestine isolated from crayfish were not influenced, peristalsis and ACh-induced contraction in the small intestine from mice were slightly accelerated, but adrenaline-induced relaxation in the small intestine from mice was not affected. Histamine-induced contraction in the small intestine and tracheal muscles isolated from guinea pigs was antagonized slightly, or not at all by NSP in a high concentration. NSP had no direct action nor anti-ACh action on abdominal muscles from frogs. NSP had no influence on E1-mice-convulsions. Both spontaneous motor activities and exploratory movements in mice were depressed. Sleeping time induced by hexobarbital-Na was prolonged in mice. Tremorine-induced tremor in mice was inhibited by NSP, while perphenazine-induced catalepsy in rats was not. Normal blood pressure in Wistar rats was not influenced, but high blood pressure in SHR (spontaneously hypertensive rats) decreased close to normal levels after NSP. NSP had antiulcerogenic effects on Takagi's restraint-plus-water-immersing ulcers in rats and histamine-induced duodenal ulcers in guinea pigs, but no influence on Shay ulcers in Wistar rats. From the data obtained herein, it may be concluded that NSP has many central depressant-like activities.
D000109:Acetylcholine / Q000037:antagonists & inhibitors; D000818:Animals; D000897:Anti-Ulcer Agents; D000959:Antihypertensive Agents; D001001:Anura; D003400:Astacoidea; D001794:Blood Pressure / Q000187:drug effects; D002375:Catalepsy / Q000188:drug therapy; D002490:Central Nervous System / Q000187:drug effects*; D004357:Drug Synergism; D005106:Exploratory Behavior / Q000187:drug effects; D005260:Female; D006168:Guinea Pigs; D006591:Hexobarbital; D006801:Humans; D066298:In Vitro Techniques; D008124:Locomotion / Q000187:drug effects; D008297:Male; D051379:Mice; D010437:Peptic Ulcer / Q000188:drug therapy; D011134:Polysaccharides / Q000494:pharmacology*; D051381:Rats; D012640:Seizures; D012890:Sleep / Q000187:drug effects; D014202:Tremor / Q000188:drug therapy; D014203:Tremorine / Q000037:antagonists & inhibitors
D000897:Anti-Ulcer Agents; D000959:Antihypertensive Agents; D011134:Polysaccharides; D006591:Hexobarbital; D000109:Acetylcholine; D014203:Tremorine