Postpartum hypertension and convulsion after oxytocic drugs.
An 18-year-old primipara developed acute hypertension leading to cerebral edema and convulsions following the IV injection of a bolus of 10 units of oxytocin with 0.2 mg methylergonovine maleate. Oxytocin in a dose of more than 2 units should not be administered IV in a single injection, as severe hypotension may result. If oxytocin is required, it can be injected either IM, or by IV pump or drip. The use of ergot in obstetrics should be limited to the treatment of life-threatening postpartum hemorrhage and be given only by the IM route. Ergot should not be administered to patients with cardiac, renal, or hypertensive disease, or in association with a vasoconstrictor.
D000293:Adolescent; D005260:Female; D006801:Humans; D006973:Hypertension / Q000139:chemically induced*; D007275:Injections, Intravenous; D007751:Labor, Induced; D010121:Oxytocin / Q000008:administration & dosage / Q000009:adverse effects*; D011247:Pregnancy; D011644:Puerperal Disorders / Q000139:chemically induced*; D012640:Seizures / Q000139:chemically induced*
D010121:Oxytocin