[Structural changes in nucleoprotein systems under the influence of serum from ill and healthy subjects].
A thermomechanical method was applied to the study of the interaction of the model desoxyribonucleoprotein systems (DNP-systems) of chromatin with the blood sera of healthy and sick persons. It was demonstrated that the blood sera of healthy persons caused decondensation of the DNP-systems. The intensity of this action varied when the sera with the composition altered as a result of pathology were used: the sera of the patients suffering from systemic lupus erythematosus increased the condensation; in comparison with the sera of healthy persons, the sera of schizophrenic patients intensified the DNP-system decondensation. The sera action was not connected with the activity of the serum enzymes. The role played by the serum components in regulation of the structural-functional chromatin properties is discussed.
D002843:Chromatin; D003852:Deoxyribonucleoproteins; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000097:blood*; D009698:Nucleoproteins; D012559:Schizophrenia / Q000097:blood*
D002843:Chromatin; D003852:Deoxyribonucleoproteins; D009698:Nucleoproteins
Strukturnye izmeneniia nukleoproteidnykh sistem pod vliianiem syvorotok krovi zdorovykh i bol'nykh liudeĭ