Decreased transforming ability of a temperature-sensitive mutant of human adenovirus type 12.
A mutant of human adenovirus type 12, temperature-sensitive for virus replication an for the enhancement of thymidine incorporation in resting human embryonic kidney cells, is described. The mutant was also temperature-sensitive for transformation of rat cells. The results indicate that a viral gene required for the virus growth cycle is also required for transformation.
D000260:Adenoviruses, Human / Q000276:immunology / Q000378:metabolism; D000956:Antigens, Viral / Q000032:analysis; D002471:Cell Transformation, Neoplastic; D002478:Cells, Cultured; D004279:DNA, Viral / Q000096:biosynthesis; D005796:Genes; D009154:Mutation; D013696:Temperature; D014779:Virus Replication
D000956:Antigens, Viral; D004279:DNA, Viral