Carcinogenic effects of a single dose of diethylnitrosamine in three unrelated strains of mice: genetic dependence of the induced tumor types and incidence.
The carcinogenic effects of a single dose of diethylnitrosamine (DEN) were studied in three inbred strains of mice. The most predominant tumors observed were lung adenomas, leukemia, and liver tumors. Mice of strain AKR/J developed both leukemia and lung tumors; SWR/J mice were most susceptible to lung tumor development; and in C57BL/6J mice liver lesions including liver tumors occurred. The influence of the genetic background on the organ susceptibility to DEN-carcinogenesis is discussed.
D000818:Animals; D002273:Carcinogens; D004052:Diethylnitrosamine / Q000633:toxicity*; D005260:Female; D005838:Genotype; D007942:Leukemia, Experimental / Q000139:chemically induced; D008113:Liver Neoplasms / Q000139:chemically induced; D008175:Lung Neoplasms / Q000139:chemically induced; D008297:Male; D051379:Mice; D008806:Mice, Inbred AKR; D008810:Mice, Inbred C57BL; D008815:Mice, Inbred Strains; D009374:Neoplasms, Experimental / Q000139:chemically induced / Q000235:genetics*; D009602:Nitrosamines / Q000633:toxicity*
D002273:Carcinogens; D009602:Nitrosamines; D004052:Diethylnitrosamine