[Catalytic activity of UDPAG-2-epimerase in the rat. Probable use in the differential diagnosis of diseases in man].
In this communication, we report, for the first time in the literature, on the presence of UD-PAG-2'-epimerase catalytic activity in various organs; i.e. kidney, brain, heart, testicle, and pancreas of rat (Mus norvegicus albinus) and the kinetical behavior of hepatic and renal activities are compared in a preliminary way. The subcellular distribution, the enzymatic stability at 4 degrees C., the catalytical efficiency and stability as a function of pH, and the enzymatic activity and differential denaturation as a function of the temperature would allow to postulate on the existence of UDPAG=2'-epimerase isozymes. The medical importance of such a differential kinetical behaviour of UDPAG-2'-epimerase as a function of its tissue origin is stressed, particularly in connection to the differential diagnosis, prognosis and treatment of various human diseases.
D000743:Anemia, Hemolytic / Q000201:enzymology*; D000818:Animals; D001921:Brain / Q000201:enzymology; D003937:Diagnosis, Differential; D007535:Isomerases / Q000378:metabolism*; D007668:Kidney / Q000201:enzymology; D007674:Kidney Diseases / Q000201:enzymology*; D008099:Liver / Q000201:enzymology; D008107:Liver Diseases / Q000201:enzymology*; D008297:Male; D009206:Myocardium / Q000201:enzymology; D010179:Pancreas / Q000201:enzymology; D019998:Racemases and Epimerases / Q000378:metabolism*; D051381:Rats; D013737:Testis / Q000201:enzymology
D007535:Isomerases; D019998:Racemases and Epimerases
Actividad catalítica de la UDPAG-2'-epimeraza en la rata. Probable utilidad en el diagnśtico diferencial de padecimentos humanos