Adenylate cyclase activity in heart and lung: effect of epinephrine and histamine in control and sensitized guinea pigs.
The effect of epinephrine and histamine on adenylate cyclase activity in lungs and hearts of control and ovalbumin-sensitized guinea pigs was investigated. Epinephrine at 10(-6) M concentration stimulated adenylate cyclase from both organs of the sensitized animals but had no effect on the enzyme from control tissues. At 10(-4) M, epinephrine stimulated equally the enzyme activity from the control and sensitized lungs and hearts. Histamine, 10(-6) and 10(-4), stimulated equally adenylate cyclase in tissues from both groups of animals. The results suggest that ovalbumin sensitization leads to hypersensitivity of the beta-adrenergic receptors to epinephrine without changing their sensitivity to histamine.
D000262:Adenylyl Cyclases / Q000378:metabolism*; D000818:Animals; D000937:Antigen-Antibody Reactions; D000941:Antigens; D004837:Epinephrine / Q000494:pharmacology*; D006168:Guinea Pigs; D006632:Histamine / Q000494:pharmacology*; D006969:Hypersensitivity, Immediate / Q000201:enzymology*; D008168:Lung / Q000201:enzymology* / Q000276:immunology; D008297:Male; D008954:Models, Biological; D009206:Myocardium / Q000201:enzymology* / Q000276:immunology; D010047:Ovalbumin / Q000276:immunology
D000941:Antigens; D006632:Histamine; D010047:Ovalbumin; D000262:Adenylyl Cyclases; D004837:Epinephrine