[Changes in the primary structure of rabbit muscle aldolase under the influence of valine against a background of prolonged fasting].
The primary structure of the muscle aldolase molecule was studied as affected by semilethal doses of valine administered the abdominal cavity of the rabbits after a long fasting. It is established that in spite of differences in the amino acid composition of the protein, uniformity of the peptides distribution in the process of bromo-cyanogen fragments elution and the total amount of amino acid residues in the identical fragments are maintained. Changes are found only in the point-replacements by amino acids in C-fragment of the molecule (asparagine is replaced by valine and threonine by serine).
D000595:Amino Acid Sequence; D000818:Animals; D004305:Dose-Response Relationship, Drug; D005215:Fasting; D005634:Fructose-Bisphosphate Aldolase / Q000032:analysis / Q000378:metabolism*; D008968:Molecular Conformation; D009132:Muscles / Q000201:enzymology*; D010443:Peptide Chain Termination, Translational / Q000187:drug effects; D010446:Peptide Fragments / Q000494:pharmacology; D011817:Rabbits; D013329:Structure-Activity Relationship; D013997:Time Factors; D014633:Valine / Q000494:pharmacology*
D010446:Peptide Fragments; D005634:Fructose-Bisphosphate Aldolase; D014633:Valine
Zminy pervynnoï struktury aldolazy míaziv kroliv pid vplyvom valinu na foni tryvaloho holoduvannia