Carrageenan and dextran in rats.
Carrageenan injected subcutaneously into one hindpaw of the rat produces an anaphylactoid reaction which prevents the same paw responding to a second dose 14 days later but does not alter the response to dextran. However, dextran does not modify the response of the hindpaw to a subsequent dose of either dextran or carrageenan 14 days later. When using these models of inflammation for testing the anti-inflammatory activity of drugs, valuable extra information may be gained by adopting the cross-over technique and using both paws of each animal.
D000707:Anaphylaxis; D000818:Animals; D000941:Antigens; D002351:Carrageenan / Q000276:immunology*; D003429:Cross Reactions; D003911:Dextrans / Q000276:immunology*; D007279:Injections, Subcutaneous; D051381:Rats; D012882:Skin Tests; D013997:Time Factors
D000941:Antigens; D003911:Dextrans; D002351:Carrageenan