Mass-spectrographic evidence of the conversion of p-chloroamphetamine to 3,4-dimethoxyamphetamine.
Intraventricularly injected p-chloroamphetamine (p-CA) was actively metabolized to 3,4-dimethoxyamphetamine (3,4-DMA) in the rat brain. Time-course experiments with intraperitoneally injected p-CA confirmed that the presence of cerebral 3,4-DMA was not due to its "one-pass" entry from the peripheral organs. The identity of 3,4-DMA from brain tissue and urine was established by comparison to authentic 3,4-DMA. The synthetic and biological samples were isographic in all analytical systems. 3,4-DMA from biological samples was verified by mass spectrography.
D000661:Amphetamine / Q000378:metabolism*; D000662:Amphetamines / Q000378:metabolism*; D000818:Animals; D001711:Biotransformation; D001921:Brain / Q000378:metabolism; D002849:Chromatography, Gas; D004305:Dose-Response Relationship, Drug; D008297:Male; D013058:Mass Spectrometry; D051381:Rats; D010133:p-Chloroamphetamine / Q000008:administration & dosage / Q000378:metabolism*
D000662:Amphetamines; D010133:p-Chloroamphetamine; D000661:Amphetamine