[In vitro metabolism of ubiquinone and ubichromenol in the livers of rats with avitaminosis E during individual and combined addition of alpha-tocopherol and phenylalanine].
A maximal incorporation of 2-14C-acetate into ubiquinone and ubichromenol was found within 3 hrs if liver tissue homogenate of E-avitaminous rats was incubated for 4 hrs. Phenylalanine, added to the mixture, stimulated the biosynthesis of ubiquinone and ubichromenol in the liver tissue preparations. alpha-Tocopherol caused an increase in biosynthesis of ubiquinone and a decrease in the rate of ubichromenol biosynthesis within 1 hr and 3 hrs of incubation in vitro. The combined addition of phenylalanine and alpha-tocopherol, almost without exceptions, increased the effect of alpha-tocopherol on biosynthesis of the substances studied. Interrelationship is discussed between vitamin E and ubiquinone and ubichromenol biosynthesis.
D000818:Animals; D008099:Liver / Q000378:metabolism*; D010649:Phenylalanine / Q000008:administration & dosage / Q000627:therapeutic use*; D051381:Rats; D014451:Ubiquinone / Q000378:metabolism*; D014810:Vitamin E / Q000008:administration & dosage / Q000627:therapeutic use*; D014811:Vitamin E Deficiency / Q000188:drug therapy*
D014451:Ubiquinone; D014810:Vitamin E; D010649:Phenylalanine
Izuchenie in vitro obmena ubikhinona i ubikhromenola v pecheni E-avitaminoznykh krys pri razdel'nom i sovmestnom dobavlenii alpha-tokoferola i fenilalanina