[Changes in the incorporation of labelled amino acids into proteins and homogenates of the brains of rats that have suffered acute hypoxia in the antenatal period].
The authors studied C14-leucine and S35-methionine incorporation into the brain tissue homogenates and protein from different parts of the brain of rats subjected to intrauterine hypoxia. Depression of protein synthesis in certain brain structures, particularly in the hyppocampus was observed alongside with the stimulation of the amino acid incorporation into proteins of the other parts of the brain. Changes of the amino acid penetration into tissue homogenates fialed to correlate with the rate of their incorporation into proteins in separate structures of the brain. Experimental results pointed to disfunction in the protein metabolism intensity and in the blood-brain barrier system occurring during the late ontogenesis in rats surviving the intrauterine hypoxia.
D000818:Animals; D001812:Blood-Brain Barrier; D001921:Brain / Q000378:metabolism*; D005260:Female; D005311:Fetal Hypoxia / Q000378:metabolism*; D002534:Hypoxia, Brain / Q000196:embryology / Q000378:metabolism*; D007930:Leucine / Q000378:metabolism; D008715:Methionine / Q000378:metabolism; D009419:Nerve Tissue Proteins / Q000096:biosynthesis*; D011247:Pregnancy; D051381:Rats
D009419:Nerve Tissue Proteins; D008715:Methionine; D007930:Leucine
Izmeniia vkliucheniia mechenykh aminokislot v belki i gomogenaty tkani raznykh otdelov mozga krys, perenesshikh ostruiu gipoksiiu v antenatal'nom periode