Alterations of the Z-band in cardiac and skeletal muscles.
The heart muscle may react to various hypoxic damaging effects (e.g.N2, CO, haemorrhagic shock, electroshock) by identical responses similarly as in the case of skeletal muscle damages. One of the early manifestations of the process is the alteration of the Z-band, which is considered pathological. The alterations of the Z-band region precede the changes of the mitochondrial and sacrotubular systems and might form the morphological basis of functional changes induced by hypoxic effects. The alterations observed are differentiated from the hypertrophy of the Z-band. In the development of the alterations of the Z-band the role of other factors (e.g. calcium metabolism, sacroplasmatic membrane changes) is emphasized.
D000818:Animals; D004285:Dogs; D006801:Humans; D000860:Hypoxia / Q000209:etiology / Q000473:pathology; D009132:Muscles / Q000648:ultrastructure*; D009133:Muscular Atrophy / Q000473:pathology; D009135:Muscular Diseases / Q000473:pathology; D009206:Myocardium / Q000648:ultrastructure*; D051381:Rats; D012771:Shock, Hemorrhagic / Q000473:pathology; D013848:Thigh