Hypersensitivity to suxamethonium in a Suffolk family.
Suxamethonium apnoea developed in a patient who was a homozygote for the atypical gene. Fifty-five members of the patient's family were investigated. Seven further homozygotes were found. Suxamethonium apnoea had been demonstrated previously in one of these. Thirty-two members of the family were heterozygotes.
D000328:Adult; D001049:Apnea / Q000139:chemically induced; D002802:Cholinesterases / Q000097:blood; D004342:Drug Hypersensitivity / Q000235:genetics*; D005260:Female; D006720:Homozygote; D006801:Humans; D010375:Pedigree; D013390:Succinylcholine / Q000009:adverse effects*
D002802:Cholinesterases; D013390:Succinylcholine