title: Iatrogenic breaks in Buuch's membrane in choroidal melanoma.
abstract: Three patients with choroidal melanoma have been observed to develop subretinal hemorrhages associated with their ocular examinations. One hemorrhage appears to have been caused by transillumination, while two others have occurred during radioactive phosphorus testing. Histopathology confirms defects in Bruch's membrane through which blood or tumor cells have entered the subretinal space.
mesh_terms: D000328:Adult; D002829:Choroid / Q000293:injuries* / Q000473:pathology; D002830:Choroid Neoplasms / Q000175:diagnosis* / Q000473:pathology; D005260:Female; D005451:Fluorescein Angiography; D006801:Humans; D007049:Iatrogenic Disease; D008297:Male; D008545:Melanoma / Q000175:diagnosis* / Q000473:pathology; D008566:Membranes / Q000473:pathology; D008875:Middle Aged; D009366:Neoplasm Seeding; D010761:Phosphorus Radioisotopes / Q000009:adverse effects*; D012166:Retinal Hemorrhage / Q000209:etiology; D012421:Rupture; D014172:Transillumination / Q000009:adverse effects*
chemical_list: D010761:Phosphorus Radioisotopes