title: Phase-plane analysis of action potentials in uterine smooth muscle.
abstract: Action potentials were recorded by microelectrode from narrow strips of pregnant rat uterus in vitro. The phase-plane display (V vs dV/dt) of selected action potentials was analysed by the method of Jenerick (1964) to yield the ionic current. From this membrane current data, various parameters of the action potential were calculated. In comparison to skeletal muscle action potentials, the ionic currents were 30-100 times smaller in the uterus action potential. Epinephrine hyperpolarized the resting potentials and suppressed spontaneous activity, but did not cause any significant changes in the stimulated action potential. The after-potential may have been affected by epinephrine, preventing repetitive firing, but the data were inconclusive. The phase-plane analysis results were similar to the results of the double sucrose gap voltage clamp method on the same tissue (Kao and McCullough, 1975).
mesh_terms: D000200:Action Potentials / Q000187:drug effects; D000818:Animals; D004594:Electrophysiology / Q000379:methods; D004837:Epinephrine / Q000494:pharmacology; D005260:Female; D008564:Membrane Potentials; D008839:Microelectrodes; D009215:Myometrium / Q000502:physiology*; D011247:Pregnancy; D051381:Rats; D014590:Uterine Contraction; D014599:Uterus / Q000502:physiology*
chemical_list: D004837:Epinephrine