[LD50 values and selenium concentration in rabbit organs after parenteral administration of sodium selenite and determination of toxicity of urososelevit pro inj].
The LD50-values of sodium selenite after i/m injection to rabbits was determined by means of probit-regression straight line. Simultaneously a combination of vitamin E and sodium selenite was tested for toxicity in order to examine the effect of vitamin E on the selenium toxicity. The LD50/24h was 2.53 mg sodium selenite/kg body mass and in combination with vitamin E (30 IU vitamin E/5 mg NaSeO3) 2.73 mg/kg. Furthermore the selenium concentration was determined in blood, liver, kidney and muscles of animals which died or were killed after 24 h respectively. Not only chemical analysis but also relations of time-dose-efficiency and significantly increased LD50-values show a certain protective effect of vitamin E on selenium intoxication.
D000818:Animals; D004347:Drug Interactions; D007273:Injections, Intramuscular; D007668:Kidney / Q000032:analysis; D007928:Lethal Dose 50; D008099:Liver / Q000032:analysis; D009132:Muscles / Q000032:analysis; D011817:Rabbits; D012643:Selenium / Q000008:administration & dosage / Q000032:analysis / Q000097:blood / Q000633:toxicity*; D014810:Vitamin E / Q000494:pharmacology
D014810:Vitamin E; D012643:Selenium
LD50 und Selenkonzentration in den Organen von Kaninchen nach intramuskulärer Applikation von Natriumselenit und Prüfung der Toxizität von Ursoselevit pro inj