title: [On the mode of action of difenoxine (R15403). Part 1: Studies on isolated intestinal smooth muscle (author's transl)].
abstract: 1-(3-Cyano-3,3-diphenylpropyl)-4-phenyl-isonicotinic acid hydrochloride (difenoxine, R 15 403) in vitro acts directly on gastrointestinal smooth muscle. It inhibits spontaneous contractions, it antagonizes the histamin-induced contractions and partially inhibits acetylcholine. Compared with pethidine difenoxine appears 50 times more powerful.
mesh_terms: D000109:Acetylcholine; D000818:Animals; D000930:Antidiarrheals / Q000494:pharmacology*; D003106:Colon / Q000187:drug effects; D004157:Diphenoxylate / Q000031:analogs & derivatives; D006168:Guinea Pigs; D006632:Histamine; D006801:Humans; D007082:Ileum / Q000187:drug effects; D007422:Intestines / Q000187:drug effects*; D007540:Isonipecotic Acids / Q000494:pharmacology*; D009119:Muscle Contraction / Q000187:drug effects; D009130:Muscle, Smooth / Q000187:drug effects*
chemical_list: D000930:Antidiarrheals; D007540:Isonipecotic Acids; D004157:Diphenoxylate; D006632:Histamine; D000109:Acetylcholine
vernacular_title: Uber die Wirkungsweise von Difenoxin (R 15403). Teil 1: Versuche an der isolierten glatten Darmmuskulatur