Action of ketoprofen on hepatic lysosome in the rat.
Evidence for the stabilizing effect of ketoprofen on the lysosomal membrane is presented. Ketoprofen was as potent as indomethacin in stabilizing lysosomes subjected to changes in osmotic pressure. This effect was more marked in rats with adjuvant arthritis than in normal animals.
D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology*; D001168:Arthritis / Q000201:enzymology; D001577:Benzophenones / Q000494:pharmacology*; D005966:Glucuronidase / Q000378:metabolism; D066298:In Vitro Techniques; D007660:Ketoprofen / Q000378:metabolism / Q000494:pharmacology*; D008099:Liver / Q000187:drug effects* / Q000648:ultrastructure; D008247:Lysosomes / Q000187:drug effects* / Q000201:enzymology / Q000378:metabolism; D008297:Male; D009997:Osmotic Pressure; D051381:Rats; D013395:Sucrose
D000893:Anti-Inflammatory Agents; D001577:Benzophenones; D013395:Sucrose; D007660:Ketoprofen; D005966:Glucuronidase