Lupus erythematosus exacerbated by griseofulvin.
Because griseofulvin is one of the safest systemic medications, its side effects are often forgotten. This paper serves as a reminder that griseofulvin can precipitate or exacerbate lupus erythematosus. Two patients are described: one had a photosensitivity reaction to griseofulvin which precipitated discoid LE skin lesions, without any previous evidence of LE. The other, who had known systemic LE, developed a systemic reaction, consisting of fever and malasise.
D006118:Griseofulvin / Q000009:adverse effects*; D006801:Humans; D008179:Lupus Erythematosus, Discoid / Q000139:chemically induced*; D008180:Lupus Erythematosus, Systemic / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D010787:Photosensitivity Disorders / Q000139:chemically induced
D006118:Griseofulvin