The fate of Depogen in rats.
Studying the metabolism of Depogen in rats we have worked out a method for the purification, isolation and separation of the drug and its potential metabolites. In the basic fraction we have found the same metabolic pathway of Drotaverin published earlier by us. In the focus of our recent work was the fate of the theophylline-7-acetic acid and its eventual biotransformed products. We have stated that theophylline-7-acetic acid contrasts with the theophylline excresa in unchanged form, which has been confirmed by several methods.
D000085:Acetates / Q000378:metabolism / Q000652:urine; D000818:Animals; D001345:Autoradiography; D002855:Chromatography, Thin Layer; D005260:Female; D008297:Male; D013058:Mass Spectrometry; D051381:Rats; D011919:Rats, Inbred Strains; D013056:Spectrophotometry, Ultraviolet; D013806:Theophylline / Q000378:metabolism* / Q000652:urine; D013997:Time Factors
D000085:Acetates; D013806:Theophylline