[Changes of arterial pressure and biosynthesis of corticosteroids in rats with neurogenic stress].
By way of a "psychogenic stimulation" (crowding for 1, 7 and 15 days) neurogenic hypertension was induced in male rats that developed in them within 11--15 days of the tsne of the stress. The biosynthesis of aldosterone, corticosterone, 11-dehydrocorticostrone and desoxycorticosterone by the adrenal glands of the rats in vitro from progesterone-14C appeared to greatly increased on the 1st day of stress. In 7 days of the beginning of stress the production of labelled corticosteroids fell to controlvalues (with the exception of 11-dehydrocorticosterone which production was growing still further). By the 15th day of stress reduction of the biosynthesis of aldosterone, corticosterone and desoxycorticosterone was observed, as well as normalization of the biosynthesis of 11-dehydrocorticosterone.
D000450:Aldosterone / Q000096:biosynthesis; D000818:Animals; D001794:Blood Pressure; D003345:Corticosterone / Q000031:analogs & derivatives / Q000096:biosynthesis; D003900:Desoxycorticosterone / Q000096:biosynthesis; D006801:Humans; D006973:Hypertension / Q000209:etiology; D008297:Male; D008901:Mineralocorticoids / Q000096:biosynthesis*; D051381:Rats; D013315:Stress, Psychological / Q000502:physiology*
D008901:Mineralocorticoids; D003900:Desoxycorticosterone; D000450:Aldosterone; D003345:Corticosterone
Izmeneniia arterial'nogo davleniia i biosinteza kortikosteroidov u krys, nakhodiashchikhsia v sostoianii neĭrogennogo stressa