[Effect of rimantadine on the synthesis of virus-specific RNA in the culture of cells infected with Sindbis virus].
Effect of rimanthadine (alpha-methyl-I-adamantane methylamine) on the synthesis of virus specific RNA was studied in culture of cells, infected with Syndbis virus. Rimanthadine inhibits the synthesis of virus specific RNA beginning from the 3-rd hr of infection. A magnitude of inhibition from the 3-rd to the 7-th hrs of infection was practically the same and exceeded 50%. In the presence of rimanthadine "early" RNA was formed (with sedimentation constant of 20-14 S), where radioactivity was lowered as compared with control; formation of more "late" RNA peaks (43 S, 34 S and 26 S) was completely prevented within these periods of infection.
D000218:Adamantane / Q000031:analogs & derivatives / Q000494:pharmacology*; D000818:Animals; D001952:Bridged-Ring Compounds / Q000494:pharmacology*; D002499:Centrifugation, Density Gradient; D002642:Chick Embryo; D005347:Fibroblasts / Q000378:metabolism; D007553:Isotope Labeling; D012367:RNA, Viral / Q000032:analysis / Q000096:biosynthesis*; D012845:Sindbis Virus; D014316:Tritium; D014529:Uridine; D014779:Virus Replication / Q000187:drug effects
D001952:Bridged-Ring Compounds; D012367:RNA, Viral; D014316:Tritium; D000218:Adamantane; D014529:Uridine
Vliianie rimantadina na sintez virusspetsificheskikh RNK v kul'ture kletok, infitsirovannykh virusom Sindbis