Serum kinetics and urinary metabolism of dimethophrine in rat.
The serum kinetics and urinary metabolism of an a-sympathomimetic amine 1-(3,5-dimethoxy-4-hydroxyphenyl)-2-monomethyl-amino-ethanol (dimethophrine) were studied. For serum kinetics, seven groups of 6 rats were sacrificed at 0.083, 1, 2, 2, 4, 6 and 12 H, respectively, after tail administration of dimethophrine-7-3H. Only 1 group of 6 rats was placed into metabolism cages to collect urine at 12-h intervals during the 72 h after dimethophrine-7-3H administration as above. The metabolic identification was made by thin-layer chromatography (TLC) and the radiochromatograms were obtained by the "scraping" method. This work shows dimethophrine to be unchanged in the urine of rat.
D000818:Animals; D002855:Chromatography, Thin Layer; D004983:Ethanolamines / Q000097:blood / Q000378:metabolism* / Q000652:urine; D007275:Injections, Intravenous; D007700:Kinetics; D008297:Male; D051381:Rats
D004983:Ethanolamines