Preliminary studies of pharmacological antigonism of anaphylaxis in the horse.
Systemic anaphylaxis was induced in seven groups of ponies. Systemic hypotension, pulmonary hypotension, and apnea were observed in the control group. Suppression of anaphylaxis was achieved most efficiently with sodium meclofenamate followed by acetylsalicylic acid and diethylcarboamazine. Tripelennamine and methysergide reduced anaphylaxis minimally and burimamide not at all. The findings suggest that histamine and serotonin are of relatively low significance in equine anaphylaxis whereas kinins, prostaglandins and slow reacting substance may be more important.
D000707:Anaphylaxis / Q000188:drug therapy / Q000503:physiopathology / Q000662:veterinary*; D000818:Animals; D001241:Aspirin / Q000627:therapeutic use; D001794:Blood Pressure; D001920:Bradykinin / Q000627:therapeutic use; D004049:Diethylcarbamazine / Q000627:therapeutic use; D005260:Female; D006632:Histamine / Q000627:therapeutic use; D006734:Horse Diseases / Q000188:drug therapy* / Q000276:immunology / Q000503:physiopathology; D006736:Horses; D008297:Male; D008469:Meclofenamic Acid / Q000627:therapeutic use; D008688:Methacholine Compounds / Q000627:therapeutic use; D008784:Methysergide / Q000627:therapeutic use; D012119:Respiration; D012701:Serotonin / Q000627:therapeutic use; D014309:Tripelennamine / Q000627:therapeutic use
D008688:Methacholine Compounds; D012701:Serotonin; D014309:Tripelennamine; D008469:Meclofenamic Acid; D006632:Histamine; D001241:Aspirin; D001920:Bradykinin; D004049:Diethylcarbamazine; D008784:Methysergide