Lack of platelet factor-3 activation after incubation of platelet-rich plasma with kaolin in the rat.
Stypven times, measured in rat platelet-rich plasma (P.R.P.) after incubation with kaolin, did not shorten as incubation proceeded, thus reflecting the lack of development of platelet factor-3 (PF3) availability in this test system. Repeated freezing and thawing of P.R.P. or aggregation with collegan did result in PF-3 availability. Aggregation and PF-3 availability were inhibited by the compound VK774. These findings add another aspect to the list of species differences in platelet function.
D000818:Animals; D001779:Blood Coagulation Factors / Q000378:metabolism*; D001780:Blood Coagulation Tests; D001792:Blood Platelets / Q000187:drug effects / Q000378:metabolism* / Q000502:physiology; D003094:Collagen; D005615:Freezing; D007616:Kaolin; D008297:Male; D010974:Platelet Aggregation; D010977:Platelet Factor 3 / Q000378:metabolism*; D051381:Rats; D013045:Species Specificity
D001779:Blood Coagulation Factors; D007616:Kaolin; D010977:Platelet Factor 3; D003094:Collagen