[Role of hypocorticosteronemy in the self cure mechanism in rats with Strongyloides ratti parasites (author's transl)].
Repeated injections of corticosterone acetate, physiological hormone of the Rat, in rats carrying Strongyloides ratti, oppose the deparasiting which normally takes place spontaneously. The secretion induced by this hormone by impregnating the organism through the corticotropic factor administered in the form of tetracosactide-zinc, achieves the same result. During all these treatments, an important hypercorticosteronemy is established. Stopping the injections is quickly followed by the worms-being rejected and the corticosteronemy returning to normal. The relations between the corticosteronemy and the parasitism are analysed and lead to the conclusion that the parasite induces an aspecific hypocorticosteronemiant reaction which, through its aspecific and specific repercussions, participates in the self-cure phenomenon.
D000818:Animals; D000917:Antibody Formation / Q000187:drug effects; D003345:Corticosterone / Q000097:blood* / Q000494:pharmacology; D051381:Rats; D013045:Species Specificity; D013321:Strongyloides / Q000187:drug effects* / Q000276:immunology
D003345:Corticosterone
Rôle de l'hypocorticostéronémie dans le mécanisme de la "self-cure" des rats, parasités par Strongyloides ratti