Effect of graded coronary stenosis on regional myocardial blood flow and left ventricular function.
Dogs with 70% stenosis of the left circumflex coronary artery showed a reduction of myocardial blood flow with a minimal impairment of left ventricular wall motion. Eighty to ninety percent stenosis produced a marked reduction of flow and wall motion, and ST elevation close to 100% occlusion, but delayed antegrade run-off was found. The effectiveness of collaterals to protect against left ventricular dysfunction was supported.
D000818:Animals; D001020:Aortic Stenosis, Subvalvular / Q000503:physiopathology*; D001794:Blood Pressure; D002312:Cardiomyopathy, Hypertrophic / Q000503:physiopathology*; D003326:Coronary Circulation; D004285:Dogs; D006352:Heart Ventricles / Q000503:physiopathology