title: Histopathological changes and the genesis of adiaspiromycomas in mice infected intraperitoneally with Emmonsia cresens Emmons et Jellison, 1960.
abstract: Following an intraperitoneal inoculation with a suspension of aleuries of the funtus Emmonsia crescens, characteristic adiaspiromycomas originate in the abdominal cavity; a generalisation of the infection was caused by lymphogenic and haematogenic dissemination. At first, fragments of the mycelium became implanted and started to grow on the peritoneum; these were quickly destroyed by a gradually increasing leukocytic reaction. In the first month of infection nodules were formed mainly on predisposed sites in the abdominal cavity. Inside these nodules we found aleuries in the granulation tissue and a necrotic centre enclosing the accumulated inoculum. Development was delayed in aleuries released from agar particles after their resorption and in aleuries originating from remnants of the inoculum. This accounted for an initial heterogeneity of spherules in the nodules. The original nodules fus-d and formed large fibrous adiaspiromycomas. In the following months atypical spherules produced in large numbers by minute, developmentally retarded, budding spherules from the zone bordering the centres, were found inside these cel layer succumbed to regressive changes. The viability of these large spherules was confirmed by a finding of live adiaspores even at as late a time as 19 months after infection.
mesh_terms: D000818:Animals; D002912:Chrysosporium / Q000254:growth & development*; D006099:Granuloma / Q000473:pathology*; D007274:Injections, Intraperitoneal; D051379:Mice; D003904:Mitosporic Fungi / Q000254:growth & development*; D009181:Mycoses / Q000382:microbiology / Q000473:pathology*; D010537:Peritoneum / Q000473:pathology