title: [Relationship between tryptophan metabolism and the state of melaninogensis].
abstract: In studying the excretion of tryptophan and the activity of tryptophan pyrrholase of the liver in black and albino rabbits it was revealed that the kinurenine, kinurenic and xanthurenic acids, 3-hydroxykinurenin, anthranylic acid and 5-hydroxyindolylactic acid levels in the urine collected before the L-tryptophane loading differed in these animals. No 3-hydroxyanthranylic acid was found in the initial urine of these rabbits. A sharp intensification of excretion of all the tryptophane metabolites studied followed the administration of L-tryptophane to albino rabbits, and a harper elevation of kinurenic and xanthurenic acid excretion--to black rabbits. In comparison with black rabbits, the tryptophan pyrrholase of the liver of albino rabbits reached to the L-tryptophan administration more intensively.
mesh_terms: D000818:Animals; D006897:Hydroxyindoleacetic Acid / Q000652:urine; D007736:Kynurenic Acid / Q000652:urine; D007737:Kynurenine / Q000031:analogs & derivatives / Q000652:urine; D008099:Liver / Q000201:enzymology; D008543:Melanins / Q000096:biosynthesis*; D011817:Rabbits; D014364:Tryptophan / Q000378:metabolism*; D014366:Tryptophan Oxygenase / Q000378:metabolism; D014977:Xanthurenates / Q000652:urine; D062367:ortho-Aminobenzoates / Q000652:urine
chemical_list: D008543:Melanins; D014977:Xanthurenates; D062367:ortho-Aminobenzoates; D007737:Kynurenine; D006897:Hydroxyindoleacetic Acid; D014364:Tryptophan; D014366:Tryptophan Oxygenase; D007736:Kynurenic Acid
vernacular_title: Osobennosti obmena triptofana v zavisimosti ot sostoianiia melaninogeneza