[Tissue metabolism of thyroid hormones in cirrhosis of the liver].
Content and ratio of products of iodothyronine tissue metabolism was studied in liver tissue of rats in normal state and in hepatocirrhosis after administration of 125I-thyroxin. The distinct decrease was observed in accumulation, deiodination and conjugation of thyroxin; the hormone was also converted into triiodothyronine in cirrhotically altered liver tissue. The importance of liver tissue in maintenance of hormonal homeostasis and biological activation of thyroid hormones is discussed.
D000818:Animals; D008099:Liver / Q000378:metabolism*; D008103:Liver Cirrhosis / Q000378:metabolism*; D008297:Male; D051381:Rats; D013974:Thyroxine / Q000378:metabolism*; D014284:Triiodothyronine / Q000378:metabolism*
D014284:Triiodothyronine; D013974:Thyroxine
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