Effects of insulin on mammalian cardiac muscle.
Insulin increases the contractile force of myocardium with hyperpolarization and a faster rate of fall of the action-potential plateau. This phenomenon is augmented inthe reduced-K+ or ouabain solution. It is suggested that the insulin-induced positive inotropism can be explained by facilitation of inward movement of Ca2+, which possibly is associated with an increase in outward movement of K+.
D000200:Action Potentials / Q000187:drug effects; D000818:Animals; D001693:Biological Transport, Active / Q000187:drug effects; D002118:Calcium / Q000378:metabolism; D004285:Dogs; D006352:Heart Ventricles / Q000187:drug effects; D007328:Insulin / Q000494:pharmacology*; D007700:Kinetics; D008564:Membrane Potentials / Q000187:drug effects; D009200:Myocardial Contraction / Q000187:drug effects*; D010042:Ouabain / Q000494:pharmacology; D011188:Potassium / Q000494:pharmacology; D016276:Ventricular Function
D007328:Insulin; D010042:Ouabain; D011188:Potassium; D002118:Calcium