[Influence of a low-protein diet on the acute toxicity of a pesticide: Nabam].
Male rats are fed during twenty eight days from the weaning with semi-synthetic isocaloric diets containing 3,5 p. 100 and 26 p. 100 of proteins under the from of casein and with a standard laboratory diet. At the end of this period the LD50 and the pathological clinical syndrome of a fungicid belonging to the dithiocarbamate series : the Nabame, are determined in each of the groups of rats receiving their respective diet. The LD50 is significantly reduced among the rats with a deficiency in proteins compared with the LD50 determined among the two other groups of animals. A likely explanation is to be looked for, at least for a part, on the level of the production or of the activity of detoxicating microsomal hepatic enzymes which the restrictions of nitrogen supply could reduce. The pathological - clinical syndrome of toxicity : stimulation then depression of the central nervous system, severe inflammation of the gastro-intestinal tract, important renal necrosis, is essentially the same among all the animals and it does not seem to be influenced by the level or nature of the proteinic supply.
D000311:Adrenal Glands / Q000473:pathology; D000818:Animals; D002364:Caseins; D005028:Ethylenebis(dithiocarbamates); D005659:Fungicides, Industrial / Q000633:toxicity*; D007422:Intestines / Q000473:pathology; D007668:Kidney / Q000473:pathology; D007928:Lethal Dose 50; D008099:Liver / Q000473:pathology; D008297:Male; D008862:Microsomes, Liver / Q000201:enzymology; D011488:Protein Deficiency / Q000150:complications*; D051381:Rats; D012469:Salivary Glands / Q000473:pathology; D013154:Spleen / Q000473:pathology; D013270:Stomach / Q000473:pathology; D013859:Thiocarbamates / Q000633:toxicity*; D013950:Thymus Gland / Q000473:pathology
D002364:Caseins; D005028:Ethylenebis(dithiocarbamates); D005659:Fungicides, Industrial; D013859:Thiocarbamates; C005270:nabam
Influence d'un régime alimentaire hypoproteique sur la toxicité aigue d'un pesticide: le nabame