title: [Penetration, permeation and resorption of heparin. In vivo studies on human skin].
abstract: The penetration and permeation of radioactive heparin into human skin was investigated as well as absorption and excretion. Heparin concentrations and vehicles were those that are in common use in practical therapy. It was shown that in spite of its high molecular weight, heparin can penetrate through the intact horny layer barrier. The concentration of heparin found in the skin, e.g. 10 I.U./ml in the epidermis and 0.6 I.U./ml in the corium are biologically relevant and are expected to be able to exert an influence. The penetration rates have shown a clear dependence on the kind of vehicle.
mesh_terms: D006493:Heparin / Q000008:administration & dosage / Q000378:metabolism*; D006801:Humans; D009823:Ointment Bases; D012869:Skin Absorption
chemical_list: D009823:Ointment Bases; D006493:Heparin
vernacular_title: Penetration, Permeation und Resorption von Heparin. In-vivo-Untersuchungen an der menschlichen Haut