[Influence of an antispastic, analgesic combination on blood pressure, dynamics and contractility of the left ventricle in the dog].
The following cardiovascular parameters were continuously measured in 12 dogs anaesthetized with sodium pentobarbital following i.v. application of Baralgin, a combination of 1-beta- piperidino-ethoxycarbmethoxy-benzophenone-hydrochloride with diphenylpiperidino-ethyl-acetamide-bromomethylate and 2.3-dimethyl-4-methylamino-1-phenyl-5-pyrazolone-N-methanesulfonic acid: Mean arterial blood pressure, left ventricular pressure, dp/dt-value in the left ventricle, the parameter (see article), told peripheral resistance, cardiac work, heart rate, cardiac output and stroke volume, flow rate in the A. femoralis and the repiration volume. In this experimental series dosages of 0.1, 0.25, 0.625 and 1.56 ml Baralgin/kg i.v. were tested and the subsequent cardiovascular activity was recorded for a period of 90 min following application. 1. The mean arterial blood pressure remained practically unaltered following low doses of Baralgin (0.1 and 0.25 ml/kg i.v.), whereas higher doses (0.625 and 1.56 ml/kg) led to an initial drop in blood pressure corresponding to the fall in total resistance. 2. The cardiac output rose slightly in correlation with rise in stroke volume. In the dosage range of 0.25 ml Baralgin/kg i.v. the rise in cardiac output was accentuated by an increase in heart rate. 3. The cardiac work remained relatively stable following small Baralgin doses, however, a slight diminution in cardiac work due to the fall in blood pressure and decrease in cardiac output, resulted from application of 1.56 mg/kg i.v. 4. A slight positive inotropic stimulation of the heart became apparent in the initial period following small doses of Baralgin (0.1 and 0.25 ml/kg i.v.), higher i.v. dosages caused a marginal reduction in cardiac contractility.
D000632:Aminopyrine / Q000031:analogs & derivatives*; D000818:Animals; D001577:Benzophenones / Q000494:pharmacology*; D001794:Blood Pressure / Q000187:drug effects*; D002302:Cardiac Output / Q000187:drug effects; D004177:Dipyrone / Q000494:pharmacology*; D004285:Dogs; D004338:Drug Combinations; D005260:Female; D006339:Heart Rate / Q000187:drug effects; D006439:Hemodynamics / Q000187:drug effects*; D008297:Male; D009200:Myocardial Contraction / Q000187:drug effects*; D010276:Parasympatholytics / Q000494:pharmacology*; D010880:Piperidines; D014655:Vascular Resistance / Q000187:drug effects
D001577:Benzophenones; D004338:Drug Combinations; D010276:Parasympatholytics; D010880:Piperidines; D000632:Aminopyrine; D004177:Dipyrone
Einfluss einer antispastisch und analgetisch wirksamen Kombination auf den Blutdruck, die Dynamik und die Kontraktilität des linken Ventrikels beim Hund