The use of saralasin in the recognition of angiotensinogenic hypertension.
Specific antagonists of angiotensin II (AII) such as saralasin might theoretically be of great value in the recognition of angiotensinogenic hypertension. Evidence is presented to show the importance of overcoming any existing sodium overload and of administering saralasin first in small and then in larger amounts by infusion (or injection). When this was done in 600 hypertensive patients, 62 showed a fall in blood pressure of more than 10/8 mm Hg. Further tests in 50 of these subjects indicated that the fall in blood pressure was associated with high peripheral levels of plasma renin activity (PRA) and/or abnormal renal vein PRA ratios in 94%. The procedure rarely failed to detect even mild forms of angiotensinogenic hypertension. In 62 patients found to have angiotensinogenic hypertension, the responsible lesions included unilateral renal arterial stenosis with good contralateral renal function (29%), bilateral renal disease (21%), Cushing's syndrome (6%), small vessel disease or specific excess of renin production - without other detectable renal disease - (31%) and incompletely evaluated disorders (13%). Saralasin has been of great value in simply and reliably demonstrating the presence or absence of an angiotensinogenic component in a large group of hypertensive patients.
D000328:Adult; D000804:Angiotensin II / Q000031:analogs & derivatives* / Q000502:physiology*; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D003480:Cushing Syndrome / Q000503:physiopathology; D004334:Drug Administration Schedule; D006801:Humans; D006973:Hypertension / Q000175:diagnosis* / Q000473:pathology / Q000503:physiopathology; D007668:Kidney / Q000473:pathology; D008297:Male; D051381:Rats; D012078:Renal Artery Obstruction / Q000503:physiopathology; D012082:Renal Veins / Q000378:metabolism; D012083:Renin / Q000097:blood; D012504:Saralasin / Q000008:administration & dosage / Q000494:pharmacology; D012964:Sodium / Q000378:metabolism / Q000502:physiology
D000804:Angiotensin II; D012964:Sodium; D012083:Renin; D012504:Saralasin