[Characteristics of energy metabolism in different regions of the heart, liver and kidneys in myocardial infarct after administration of prednisolone].
The effect of therapeutic doses of Prednisolone (1 mg/kg) on the indices of energy metabolism in different regions of the heart, liver and kidneys was studied in 70 dogs within the initial 10 days after the ligation of the left coronary artery. The administration of such doses of Prednisolone was found to increase the respiration of the mytochondria and especially the binding of the inorganic phosphate in the zone of the infarction, to switch over from the poorly effective oxidation in the nondamaged area of the left ventricle to the one firmly conjugated with phosphorylation, to level the balance between the respiration and phosphorylation of the mytochondria in the right ventricle, liver and kidneys. The beneficial effect of Prednisolone upon the energy metabolism in the tissues during myocardial infarction manifested itself in growing depots of ATP and creatinephosphate in all regions of the heart. This effect of Prednisolone is most clearly expressed during the initial 5 days of its administration, and is less demonstrative when given for 10 days.
D000818:Animals; D004285:Dogs; D004734:Energy Metabolism; D007668:Kidney / Q000378:metabolism*; D008928:Mitochondria / Q000378:metabolism*; D008930:Mitochondria, Liver / Q000378:metabolism*; D008931:Mitochondria, Muscle / Q000378:metabolism*; D009203:Myocardial Infarction / Q000188:drug therapy / Q000378:metabolism*; D009206:Myocardium / Q000473:pathology*; D010085:Oxidative Phosphorylation; D010101:Oxygen Consumption; D011239:Prednisolone / Q000627:therapeutic use
D011239:Prednisolone
Osobennosti energeticheskogo obmena raznykh otdelov serdtsa, pecheni i pochek pri infarkte miokarda v usloviiakh vvedeniia prednizolona