Effect of chronic exposure to nitrogen dioxide on collagen fractions content in skin of guinea pigs.
Guinea pigs were exposed to nitrogen dioxide in concentration of 2 mg/m3 (8 hrs. daily, 180 days). Control group inspired fresh air. Collagen fractions were estimated in skin and assayed as hydroxyproline concentration. An increase of total collagen content, due to on increase of salt-soluble collagen fraction was found in the skin of the exposed animals, while a simultaneous decrease of insoluble collagen content was observed.
D000818:Animals; D003094:Collagen / Q000378:metabolism*; D006168:Guinea Pigs; D006909:Hydroxyproline / Q000378:metabolism; D008297:Male; D009585:Nitrogen Dioxide / Q000494:pharmacology*; D012867:Skin / Q000187:drug effects* / Q000378:metabolism
D003094:Collagen; D006909:Hydroxyproline; D009585:Nitrogen Dioxide