[Controlled hypotension by sodium nitroprusside during neuroleptanalgesia, halothane-and enflurane anaesthesia at neurosurgical and maxillary-face-surgical operations (author's transl)].
A new sodium-nitroprusside-preparation (Nipruss) was tested in 40 patients for a controlled hypotension in neurosurgical as well as maxillary- and face-surgical operations. Differences between the phases of hypotension by Nipruss were pointed out for NLA, halothane- and enflurane-narcosis. An initial hypotension of -48 per cent, caused by Nipruss, was accompanied by an increase of the cardiac frequency of +33 per cent. This was dependent on the different methods of anaesthesia. The doses necessary for an average permanent hypotension of -36 per cent varied between 1.3 and 22.3mug/kg/min. The results proved, that Nipruss guarantees a diminished blood field even be  used without head-up-position and at moderate hypotension. In combination with halothane and enflurane, hypotension could be regulated easier than with NLA. However, this resulted often in a higher frequencyload of the heart, so that frequently beta-adrenergic blocking drugs had to be administered. The operation conditions were improved, incidents did not occur. The new preparation Nipruss has organizational and hygienic advantages.
D000328:Adult; D000769:Anesthesia, Inhalation; D001932:Brain Neoplasms / Q000601:surgery; D002971:Cleft Lip / Q000601:surgery; D002972:Cleft Palate / Q000601:surgery; D004737:Enflurane; D005145:Face / Q000601:surgery; D005260:Female; D006221:Halothane; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D007023:Hypotension, Controlled / Q000379:methods*; D008297:Male; D008437:Maxilla / Q000601:surgery; D008875:Middle Aged; D009458:Neuroleptanalgesia / Q000379:methods*; D009599:Nitroprusside; D010307:Parotid Neoplasms / Q000601:surgery; D013515:Surgery, Oral; D013514:Surgical Procedures, Operative
D009599:Nitroprusside; D004737:Enflurane; D006221:Halothane
Kontrollierte Hypotension mit Natriumnitroprussid bei Neuroleptanalgesis, Halothan- und Enfluranenarkosen im intrakraniellen sowie kiefer-, mund-und gesichtschirurgischen Operationsgut