[Effect of gamma-aminobutyric acid on peripheral mechanisms regulating autonomic functions].
Experiments with cats ascertained the potentiating action of GABA (100,300,500 mg/kg) on the pressor reactions of the small intestine vessels, the systemic arterial pressure, depressing (100 mg/kg) and facilitating (500 mg/kg) effect upon the reactions of inhibition of the small intestine motor activity evoked by the efferent stimulation of the celiac nerve. Adrenolytics (dihydroergotoxin, inderal) abolished the facilitating effects of GABA. The latter (0.01 solution) inhibited spontaneous contractions of isolated small intestine lengths. As proved histochemically GABA (500 mg/kg) reduces the catecholamines content in the suprarenals, in the solar plexus ganglia and in vessles "in vivo". It also increases the catecholamines content in the small intestine wall in experiments in vivo and reduces in vitro tests. The potentiating action of GABA on the vegetative reactions in efferent stimulation of the ciliac nerve occurs, apparently, due to an increased ejection of catecholamines by suprarenals and lowered the content of catecholamines in the solar plexus ganglia, which causes facilitated conduction of excitation in the ganglia.
D000313:Adrenal Medulla / Q000378:metabolism; D000315:Adrenalectomy; D000613:Aminobutyrates / Q000494:pharmacology*; D000818:Animals; D001341:Autonomic Nervous System / Q000187:drug effects*; D001794:Blood Pressure / Q000187:drug effects; D002395:Catecholamines / Q000378:metabolism; D002415:Cats; D002447:Celiac Plexus / Q000378:metabolism; D007421:Intestine, Small / Q000098:blood supply; D008638:Mesenteric Arteries / Q000378:metabolism; D009043:Motor Activity / Q000187:drug effects; D010528:Peristalsis; D013153:Splanchnic Nerves / Q000187:drug effects; D014666:Vasomotor System / Q000187:drug effects; D005680:gamma-Aminobutyric Acid / Q000494:pharmacology*
D000613:Aminobutyrates; D002395:Catecholamines; D005680:gamma-Aminobutyric Acid
Izuchenie deĭstviia gamma-aminomaslianoĭ kisloty na perifericheskie mekhanizmy reguliatsii vegetativnykh funktsii