[Regulation of peroxidation of mitochondrial membrane lipids initiated by Fe2+ ions by antoxidants of the 1,4-dihydropyridine series in experiments in vitro].
Effect of antioxidants on the rate of free radical peroxidation was studied in mitochondria in presence of Fe2+. For this purpose derivatives of 1,4-dihydroxypyridine, their heteroaromatic analogues, NAD-H+ and butyl hydroxytoluene (35 substances) were tested in the system by chemoluminescence. Several 1,4-dihydroxypyridine derivatives were found to be effective reagents in the system and could be compared by the activity with the recognized synthetic antioxidant butyl hydroxytoluene.
D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D055598:Chemical Phenomena; D002621:Chemistry; D006651:Histocytochemistry; D066298:In Vitro Techniques; D007501:Iron / Q000494:pharmacology*; D008297:Male; D008563:Membrane Lipids / Q000378:metabolism*; D008930:Mitochondria, Liver / Q000378:metabolism*; D011725:Pyridines / Q000494:pharmacology*; D051381:Rats
D000975:Antioxidants; D008563:Membrane Lipids; D011725:Pyridines; D007501:Iron
Reguliatsiia initsiiruemogo ionami Fe2+ perekisnogo okisleniia lipidov mitokhondrial'nykh membran v opytakh in vitro antioksidantami 1,4-digidropiridinovogo riada