Lacoferrin in rabbit bile: its relation to iron metabolism.
The relation of biliary lactoferrin concentration and the iron status of the body was studied in normal, anaemic and iron-loaded rabbits. In anaemic rabbits lactoferrin concentrations rose to two to three times the original values. Loading with iron resulted in a return to normal values. Mobilization of iron with desferrioxamine also gave a rise in lactoferrin concentration in bile. Lactoferrin may have a regulatory function in situations of enhanced iron absorption or mobilization of iron from depots.
D000740:Anemia / Q000097:blood / Q000378:metabolism; D000818:Animals; D001646:Bile / Q000032:analysis*; D003676:Deferoxamine / Q000494:pharmacology; D006454:Hemoglobins / Q000032:analysis; D007501:Iron / Q000032:analysis / Q000097:blood / Q000378:metabolism* / Q000494:pharmacology; D007781:Lactoferrin / Q000032:analysis* / Q000037:antagonists & inhibitors / Q000378:metabolism; D007782:Lactoglobulins / Q000032:analysis*; D008297:Male; D011817:Rabbits; D014168:Transferrin / Q000032:analysis
D006454:Hemoglobins; D007782:Lactoglobulins; D014168:Transferrin; D007501:Iron; D007781:Lactoferrin; D003676:Deferoxamine