Behavioral testing as a method for assessing risk.
Behavioral effects have been found to result from the prenatal administration of substances known to be teratogenic to the CNS. These effects occur at dose levels lower than those producing gross malformations and when the agent is administered at times other than that optimal for CNS relevant technique for detecting adverse consequences of prenatal exposure to drugs and chemicals. Behavioral testing, however, also appears to have attributes that dictate a thoughtful approach to its role as a method for assessing risk, and additional research is needed to obtain usable techniques. The need for such research is intensified by the present inability to identify potential behavioral teratogens by means other than laboratory investigation.
D000818:Animals; D001519:Behavior / Q000187:drug effects*; D001522:Behavior, Animal / Q000187:drug effects; D002490:Central Nervous System / Q000187:drug effects*; D004353:Drug Evaluation, Preclinical; D004781:Environmental Exposure; D005260:Female; D005333:Fetus / Q000187:drug effects*; D011247:Pregnancy; D011581:Psychological Tests; D051381:Rats; D012306:Risk; D013723:Teratogens; D014801:Vitamin A / Q000633:toxicity
D013723:Teratogens; D014801:Vitamin A