[Relationship between accumulation of o,p'-dichlorodiphenyl-dichloroethane in the adrenal glands and their function and structure].
Over a periof of 12 days following introduction of o'p-dichlordiphenyl-chlorethane to dogs in a dose of 25 mg/kg a sizable accumulation of the compound in the adrenal tissue, a drastic inhibition of its function and deragment of the suprarenal cortex structure are observed. After a 28-day administration of the compound the functional and structural upsets in the adrenals gain in strength, whereas it concentration in this organ declines.
D000302:Adrenal Cortex / Q000737:chemistry / Q000187:drug effects* / Q000473:pathology; D000304:Adrenal Cortex Function Tests; D000311:Adrenal Glands / Q000187:drug effects*; D000309:Adrenal Insufficiency / Q000139:chemically induced / Q000503:physiopathology; D000818:Animals; D001284:Atrophy / Q000139:chemically induced; D004285:Dogs; D006854:Hydrocortisone / Q000097:blood; D008297:Male; D008939:Mitotane / Q000008:administration & dosage / Q000009:adverse effects* / Q000032:analysis
D008939:Mitotane; D006854:Hydrocortisone
Zavisimost' mezhdu nakopleniem o,p'-dikhlordifenil-dikhloretana v nadpochechnikakh, ikh funktsieĭ i strukturoĭ