Influence of surgical manipulations on hexobarbital effects in rats.
In rats the hexobarbital metabolism is impaired after different surgical procedures leading to muscle damage. This leads to a prolongation of the hexobarbital action. The prolonged effect of hexobarbital in rats with lymphostatic encephalopathy is considered an unspecific consequence of the tissue damage during lymphectomy.
D000768:Anesthesia, General; D000818:Animals; D001921:Brain / Q000378:metabolism / Q000502:physiology; D006207:Half-Life; D006591:Hexobarbital / Q000008:administration & dosage / Q000378:metabolism / Q000494:pharmacology*; D008196:Lymph / Q000502:physiology; D008197:Lymph Node Excision; D008198:Lymph Nodes / Q000502:physiology*; D008297:Male; D009132:Muscles / Q000502:physiology / Q000601:surgery; D010424:Pentobarbital; D051381:Rats; D013997:Time Factors
D006591:Hexobarbital; D010424:Pentobarbital