title: [Clinicopharmacological studies with pindolol following intravenous and oral administration].
abstract: The beta-adrenoceptor blocking potency of pindolol after intravenous and after oral administration was compared in clinical pharmacological experiments in healthy volunteers. Equal doses of pindolol were aequiactive 75 min after intravenous and 2 h after oral administration on tachycardia due to isoprenaline infusions as well as on tachycardia due to exercise on the cycle ergometer. The results of this comparison of pharmacodynamic effects confirm the good enteral absorption reported in pharmacokinetic studies.
mesh_terms: D000284:Administration, Oral; D000328:Adult; D005080:Exercise Test; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D007275:Injections, Intravenous; D007408:Intestinal Absorption; D007545:Isoproterenol; D008297:Male; D010869:Pindolol / Q000008:administration & dosage* / Q000494:pharmacology / Q000627:therapeutic use; D013610:Tachycardia / Q000139:chemically induced / Q000188:drug therapy
chemical_list: D010869:Pindolol; D007545:Isoproterenol
vernacular_title: Klinisch-pharmakologische Untersuchungen mit Pindolol nach intravenöser und oraler Verabreichung.