[Study of metabolic mechanisms of the isolated and combined effect of a chemical allergen].
Biochemical study of the activity of the enzyme systems of different localization in the cell connected with the subcellular structures - lysosomes (hyaluronidase, N-acetyl-beta-D-glucosaminidase, beta-glucosidase) and hyaloplasm-soluble (aldolase of neuraminic acid), and also a study of the state of the enzyme-substrate groups, belonging to the immunoreactive biopolymeres containing a carbohydrate (glucoproteins, glycosaminoglycanes) was carried out in the tissues of different organs (the liver, kidneys, small intestine, skin) and in the blood serum of albino rats exposed to the isolated and joint (in combination with various doses of ultraviolet irradiation) action of the chemical allergen (dinitrochlorbenzene). General and specific regularities of metabolic reactions, the appearance of which could presumably be connected with the development of delayed allergy were revealed.
D000118:Acetylglucosaminidase / Q000378:metabolism; D000485:Allergens / Q000494:pharmacology*; D000818:Animals; D004137:Dinitrochlorobenzene / Q000494:pharmacology*; D005634:Fructose-Bisphosphate Aldolase / Q000378:metabolism; D005959:Glucosidases / Q000378:metabolism; D006023:Glycoproteins / Q000378:metabolism; D006025:Glycosaminoglycans / Q000378:metabolism; D006821:Hyaluronoglucosaminidase / Q000378:metabolism; D006968:Hypersensitivity, Delayed / Q000139:chemically induced; D007421:Intestine, Small / Q000473:pathology; D007668:Kidney / Q000473:pathology; D008099:Liver / Q000473:pathology; D008247:Lysosomes / Q000378:metabolism; D009578:Nitrobenzenes / Q000494:pharmacology*; D051381:Rats; D012867:Skin / Q000473:pathology; D014466:Ultraviolet Rays
D000485:Allergens; D004137:Dinitrochlorobenzene; D006023:Glycoproteins; D006025:Glycosaminoglycans; D009578:Nitrobenzenes; D005959:Glucosidases; D006821:Hyaluronoglucosaminidase; D000118:Acetylglucosaminidase; D005634:Fructose-Bisphosphate Aldolase
Issledovanie metabolicheskikh mekhanizmov izolirovannogo i sochetannogo deĭstviia khimicheskogo allergena.