[Problems of thrombogenesis and destruction of the superficial layer of implanted artificial heart valves].
Experience with the use of artificial cardiac valves has revealed basic shortcomings of their designs, viz. their hemodynamic inadequacy to natural cardiac valves and thrombogeneity. The thrombogenesis is held to be qualitatively linked with the turbulence of the blood stream on the prosthesis, but the mechanism of this phenomenon has not been explained so far. Metallographic investigations of the titanium valve surfaces, with the valves having been operative in the human body over periods of from 8 hours to 80 days, demonstrated destruction of the superficial layer of the valve's cell. The surface layer of the metal is structurally changed to a depth of 0.05 mm, has a spongy texture and is readily detachable from the bulk of the metal. The presumed cause of erosion is considered to be saturation of the surface layer with gases, possibly as a result of cavitation within the prosthesis zone.
D001021:Aortic Valve; D001783:Blood Flow Velocity; D006350:Heart Valve Prosthesis / Q000009:adverse effects*; D006439:Hemodynamics; D006801:Humans; D008943:Mitral Valve; D013927:Thrombosis / Q000209:etiology*
Problemy tromboobrazovaniia i razrusheniia poverkhnostnog o sloia implantirovannykh iskusstvennykh klapanov serdtsa