[Basic peptides in bee venom, II. Synthesis of two pentapeptides from the sequence of the mast-cell-degrading peptide (author's transl)].
The synthesis of two protected pentapeptides is described. The peptides are fragments of the sequence of a mast-cell degranulating peptide from bee venom. The fragments Boc-Lys(Z)-Ile-Cys(SiPr)-Gly-Lys(Z)(I) and Boc-Pro-His(Trt)-Ile-Cys(Trt)-Arg(Tos) (II) were synthesized conventionally. The deprotection of the alpha-amino group by HCl/acetic acid of Boc-Ile-Cys(SiPr)-Gly-Lys(Z) was accompanied by a disulfide exchange at the cysteine residue. After the hydrolysis of fragment II with 6N HCl, allo-isoleucine could be detected by gas chromatography and amino-acid analysis.
D000595:Amino Acid Sequence; D001516:Bees; D055598:Chemical Phenomena; D002621:Chemistry; D006868:Hydrolysis; D008407:Mast Cells / Q000187:drug effects; D008722:Methods; D008958:Models, Molecular; D009842:Oligopeptides / Q000032:analysis / Q000138:chemical synthesis*; D014688:Venoms
D009842:Oligopeptides; D014688:Venoms
Synthese zweier Pentapeptide aus der Sequenz des Mastzellen-degranulierenden Peptids