title: [Glisoxepide treatment in maturity-onset diabetics (author's transl)].
abstract: Patterns of blood glucose, serum insulin and non-esterified fatty acids (NEFA) were measured over a period of eight-and-a-half hours in eleven maturity-onset diabetics receiving 8 mg glisoxepide in the morning and 4 mg in the evening (while on a standard diet). The effects of administering the tablets in the morning with breakfast were compared to those on administering the drug half-an-hour (five patients) or one hour (six patients) before breakfast. Although there was a slightly earlier increase in serum insulin when tablets were taken half-an-hour or an hour before breakfast, different times of administration did not significantly affect the blood glucose or NEFA pattern. In particular, the extreme rise in blood glucose levels after the first breakfast could not be avoided.
mesh_terms: D001786:Blood Glucose / Q000032:analysis; D002940:Circadian Rhythm; D003920:Diabetes Mellitus / Q000097:blood / Q000188:drug therapy*; D005230:Fatty Acids, Nonesterified / Q000097:blood; D005260:Female; D006801:Humans; D007328:Insulin / Q000097:blood; D008297:Male; D008875:Middle Aged; D013453:Sulfonylurea Compounds / Q000008:administration & dosage / Q000627:therapeutic use*; D013997:Time Factors
chemical_list: D001786:Blood Glucose; D005230:Fatty Acids, Nonesterified; D007328:Insulin; D013453:Sulfonylurea Compounds
vernacular_title: Zur Glisoxepidbehandlung des Erwachsenendiabetes. Tagesprofile von Blutzucker, Seruminsulin und unveresterten Fettsäuren bei unterschiedlichen Zeitpunkten der Tabletteneinnahme