[Effect of a hypertonic sodium chloride solution on dye distribution in the organs and lymph of the thoracic duct].
The distribution of trephan blue in different organs and tissues and in the lymph was studied in acute experiments  on 84 dogs after the infusion of 5% NaCl solution (0.5 mg/kg). The rise of the stain concentration in the intact dogs was the greatest in the liver, the kidney and the intestine. The osmotic shift caused by the intravenous infusion of the hypertonic NaCl solution increased the blood plasma hyaluronidase activity, reduced the maximal accumulation time of the stain in the tissues and led to a 1.5-2 fold elevation in the stain concentration in the organs.
D000818:Animals; D001702:Biopharmaceutics; D004285:Dogs; D004347:Drug Interactions; D006821:Hyaluronoglucosaminidase / Q000097:blood; D007422:Intestines / Q000187:drug effects; D007668:Kidney / Q000187:drug effects; D008099:Liver / Q000187:drug effects; D008196:Lymph / Q000187:drug effects*; D012462:Saline Solution, Hypertonic / Q000494:pharmacology*; D012965:Sodium Chloride / Q000494:pharmacology*; D013897:Thoracic Duct / Q000187:drug effects*; D013997:Time Factors; D014343:Trypan Blue / Q000494:pharmacology*; D014882:Water-Electrolyte Balance / Q000187:drug effects
D012462:Saline Solution, Hypertonic; D012965:Sodium Chloride; D006821:Hyaluronoglucosaminidase; D014343:Trypan Blue
Vliianie gipertonicheskogo rastvora khloristogo natriia na raspredelenie krasitelia v organakh i limfe grudnogo protoka