title: Light stimulated 'shunt-metabolism' succinate-alpha-ketoglutarate-isocitrate cycle and accumulation of citric acid in Aspergillus niger.
abstract: Studies with light of the visible range had shown that light plays significant role in the biosynthesis and accumulation of citric acid in Aspergillus niger. Accumulation of 14C-labelled carbon atoms in alpha-ketoglutaric, isocitric, succinic and glycolic acids in the cultures grown under illumination suggest a probable 'shunt-metabolism' leading to the succinate-alpha-ketoglutarate-isocitrate (SKI) cycle. This shunt metabolism minimizes the accumulation of citric acid in cultures due to depletion of intermediates.
mesh_terms: D000085:Acetates / Q000378:metabolism; D001230:Aspergillus / Q000528:radiation effects*; D001234:Aspergillus niger / Q000378:metabolism / Q000528:radiation effects*; D002951:Citrates / Q000378:metabolism; D002952:Citric Acid Cycle / Q000528:radiation effects*; D006016:Glycolates / Q000378:metabolism; D007523:Isocitrates / Q000378:metabolism; D007656:Ketoglutaric Acids / Q000378:metabolism; D008027:Light; D013386:Succinates / Q000378:metabolism
chemical_list: D000085:Acetates; D002951:Citrates; D006016:Glycolates; D007523:Isocitrates; D007656:Ketoglutaric Acids; D013386:Succinates