[The influence of a therapy with vasodilating agents on the sleep EEG of patients with cerebral circulatory disturbances. Results of a double blind study (author's transl)].
In 30 patients (24 men, 6 women) aged from 30-74 years and suffering from ischemic lesions in the cerebral hemispheres all-night EEG recordings before and after a 3 weeks' treatment with vasodilating drugs were carried out. At the same time the development of the clinico-neurological and psychoorganic symptomatology, also using test psychological methods, were studied. The drugs--10 patients received 50 mg raubasin, 6 patients 500 mg bencyclan and the others a salt solution--were administered i.v. Under the treatment no change in the primary sleep EEG findings could be observed, whereas there was an improvement of the clinico-neurological and psychoorganic symptomatology in the drug as well as in the placebo group. The lack of improvement in mood and state of well-being is discussed in its relationship to the sleep behaviour.
D000328:Adult; D000368:Aged; D002561:Cerebrovascular Disorders / Q000188:drug therapy* / Q000503:physiopathology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011569:Psychiatric Status Rating Scales; D012890:Sleep / Q000187:drug effects*; D012894:Sleep Stages / Q000187:drug effects; D014665:Vasodilator Agents / Q000627:therapeutic use*
D014665:Vasodilator Agents
Der Einfluss einer Behandlung mit Vasodilatantien auf das Schlaf-EEG bei Patienten mit zerebralen Durchblutungsstörungen. Ergebnisse einer Doppelblindstudie