Metabolic disposition of 2-phenylethylamine and the role of depression in methadone-dependent and detoxified patients.
We have now postulated that differences in the innate capacity of individuals to synthesize, store and utilize biogenic amines may provide the biological basis for human abuse of narcotic and other drugs, and that these drugs are used in an apparent unconscious effort to self-medicate against an inherent affective disorder. In this communication, we attempted a preliminary characterization of the narcotics withdrawal syndrome on biochemical and clinical parameters. Abstinence was found to be characterized by low urinary excretion of 2-phenylethylamine and depression. An indication for use of tricyclic drugs has been discussed.
D000328:Adult; D003863:Depression / Q000503:physiopathology*; D005260:Female; D006556:Heroin Dependence / Q000534:rehabilitation; D006801:Humans; D008297:Male; D008691:Methadone / Q000494:pharmacology* / Q000627:therapeutic use; D010627:Phenethylamines / Q000652:urine*; D013375:Substance Withdrawal Syndrome / Q000209:etiology / Q000652:urine*; D019966:Substance-Related Disorders / Q000150:complications / Q000209:etiology* / Q000652:urine; D013997:Time Factors
D010627:Phenethylamines; D008691:Methadone