[Roles of noradrenergic and dopaminergic systems in the self-stimulation behavior of the substantia nigra].
A bipolar electrode was stereotaxically implanted in the substantia nigra of male albino Wistar-Imamichi rats. 1) Rats lifted and turned their heads and contralateral forelimb towards the contralateral side to the electrode during the substantia nigral self-stimulation (SS) behavior. 2) Methamphetamine facilitated the SS dose-dependently in the "threshold"-intensity reinforcement. The pretreatment of imipramine facilitated the effects of methamphetamine. 3) FLA63 and U-14,624, dopamine beta-hydroxylase inhibitors, suppressed the SS in the moderate-intensity reinforcement. 4) Apomorphine, stimulant of dopamine receptor, did not facilitate, but rather inhibited the SS dose-dependently in the "threshold"-intensity reinforcement. 5) l-Norepinephrine injected into the lateral ventricle facilitated the SS dose-dependently. On the other hand, dopamine had no marked effects. 6) These results suggest that the noradrenergic system in the brain plays a more important role in the positive reinforcement of the substantia nigral SS behavior than does the dopaminergicsystem.
D000818:Animals; D001058:Apomorphine / Q000494:pharmacology; D005406:Bis(4-Methyl-1-Homopiperazinylthiocarbonyl)disulfide / Q000494:pharmacology; D004298:Dopamine / Q000494:pharmacology / Q000502:physiology*; D004299:Dopamine beta-Hydroxylase / Q000037:antagonists & inhibitors; D004305:Dose-Response Relationship, Drug; D004558:Electric Stimulation; D007099:Imipramine / Q000494:pharmacology; D008297:Male; D008694:Methamphetamine / Q000494:pharmacology; D009638:Norepinephrine / Q000494:pharmacology / Q000502:physiology*; D010668:Phenylthiazolylthiourea; D051381:Rats; D012653:Self Stimulation / Q000187:drug effects*; D013378:Substantia Nigra / Q000502:physiology*
D010668:Phenylthiazolylthiourea; D005406:Bis(4-Methyl-1-Homopiperazinylthiocarbonyl)disulfide; D008694:Methamphetamine; D004299:Dopamine beta-Hydroxylase; D001058:Apomorphine; D007099:Imipramine; D004298:Dopamine; D009638:Norepinephrine