title: Rejection of metal to metal prosthesis and skin sensitivity to cobalt.
abstract: Metal to metal prostheses give satisfactory results in 90% of patients. About half of the failure rate may be due to allergic reaction to the metals involved, particularly cobalt. A total of 35 patients in this unsatisfactory group have been patch-tested; 16 were positive to metals, 13 to cobalt, 4 to nickel, and 2 to chromate. Only two patients showed any skin lesions - one a localized dermatitis round the knee joint from nickel sensitivity, and one to cobalt who had a widespread scattered circular erythematous lesion suggestive of a generalized allergic vasculitis. Patients requiring a metal/metal prosthesis should have a careful history taken for metal sensitivity and be patch-tested with the metals. All the patients in this investigation had metal/metal prostheses and no reaction was seen after metal/high density polyethylene implants. Titanium 318 may be a satisfactory substitute for cobalt chrome alloy if reactions are encountered.
mesh_terms: D002840:Chromates / Q000009:adverse effects; D003035:Cobalt / Q000009:adverse effects*; D003876:Dermatitis, Atopic / Q000139:chemically induced*; D006801:Humans; D006968:Hypersensitivity, Delayed / Q000175:diagnosis*; D007595:Joint Prosthesis / Q000009:adverse effects; D009532:Nickel / Q000009:adverse effects; D010328:Patch Tests; D019736:Prostheses and Implants / Q000009:adverse effects*
chemical_list: D002840:Chromates; D003035:Cobalt; D009532:Nickel