A note on single- and two-dose immunogenicity tests of inactive virus vaccine in chicks.
Single dose extinction limit test ot inactive polio vaccine in chicks lasts 4 days and offers the same results as the two-dose test which requires 14 days. When "long-term" incubation instead of "conventional" 2 hours-incubation of the serum/virus mixtures in the neutralization reaction was used, extinction limit values higher by 0.6-0.7 log10 were regularly obtained.
D000818:Animals; D000914:Antibodies, Viral / Q000096:biosynthesis; D000917:Antibody Formation; D002645:Chickens; D007117:Immunization, Secondary; D009500:Neutralization Tests; D017955:Poliovirus / Q000276:immunology; D011054:Poliovirus Vaccine, Inactivated / Q000008:administration & dosage / Q000592:standards*; D014613:Vaccines, Attenuated / Q000008:administration & dosage / Q000592:standards*
D000914:Antibodies, Viral; D011054:Poliovirus Vaccine, Inactivated; D014613:Vaccines, Attenuated