Electrochemical evidence for interaction between chlorpromazine hydrochloride and trifluoperazine hydrochloride and the flavin coenzymes.
Polarographic and chronopotentiometric methods were applied to study the effects of the phenothiazine tranquilizers chlorpromazine hydrochloride and trifluoperazine hydrochloride on the electrochemical behavior of the flavin coenzymes flavin mononucleotide and flavin adenine dinucleotide. The effects of the drugs were measured mainly by decreases in the diffusion currents, id, developed in the polarographic experiments and by a similar decrease in the chronopotentiometric constant, ior1/2, in the chronopotentiometric experiments when the coenzymes were reduced in the presence of the added drugs. The observed interference with the redox properties of the coenzymes could conceivably be related to the reported ability of the drugs to inhibit respiration and produce their tranquilizing effect.
D002746:Chlorpromazine; D005486:Flavin Mononucleotide; D005182:Flavin-Adenine Dinucleotide; D011048:Polarography; D011199:Potentiometry; D014268:Trifluoperazine
D005182:Flavin-Adenine Dinucleotide; D014268:Trifluoperazine; D005486:Flavin Mononucleotide; D002746:Chlorpromazine