[Experimental data on the penetration of gentamicin into the media of the eye].
Penetration of Soviet gentamicin into the humor of the anterior chamber and vitreous body of the eye with aseptic inflammation was studied after the antibiotic administration by various routed, i.e. instillations of 8 per cent antibiotic solution and 8 per cent antibiotic solution methylcellulose into the conjunctival sac, injections of 20 mg of gentamicin subconjunctivally and retrobulbarly, injections of gentamicin intramuscularly in doses of 0.6 mg/kg. The studies showed that gentamicin penetrated into the humor of the anterior chamber and vitreous body of the eye after all the administration routes mentioned above in concentrations sufficient for the antibiotic antimicrobial effect and persisted in the eye media for prolong periods of time (24--48 hours). The highest concentrations of the antibiotic in the tumor of the anterior chamber were achieved after its administration subconjunctivally or after instillation of its 8 per cent on methylcellulose, while in the vitreous body its highest concentrations were achieved after injections subconjunctively, retrobulbarly or intramuscularly. Instillations of gentamicin solution on methylcellulose provided higher and more persistant concentrations of the antibiotic in the humor as compared to instillations of its aqueous solutions. Retrobulbar injections of gentamicin had no advantages as compared to subconjunctival administration with respect to providing higher concentrations of the antibiotic in the eye media.
D000818:Animals; D000867:Anterior Chamber / Q000187:drug effects; D001702:Biopharmaceutics; D002463:Cell Membrane Permeability / Q000187:drug effects*; D003692:Delayed-Action Preparations; D005123:Eye / Q000187:drug effects*; D005839:Gentamicins / Q000008:administration & dosage / Q000494:pharmacology*; D009883:Ophthalmic Solutions; D011817:Rabbits; D013997:Time Factors; D014822:Vitreous Body / Q000187:drug effects
D003692:Delayed-Action Preparations; D005839:Gentamicins; D009883:Ophthalmic Solutions
Eksperimental'nye dannye o proniknovenili gentamitsina v sredy glaza