Relationship between Hb and HbA2 concentrations in beta-thalassemia trait and effect of iron deficiency anaemia.
The relationship of HbA2 to total Hb has been measured in 204 cases of Beta-Thalassaemia (beta-th-t) where the total Hb varied from 3.6 to 16 g/100 ml. The variation of total Hb in the study population was due, as far as could be defined, only to beta-th-t and a superimposed iron deficiency anaemia (IDA). Superimposed IDA decreases HbA2 proportionately more than it does total Hb (P less than 0.001). A not previously described relationship between HbA2 and total Hb was demonstrated and probably conformed to a second degree parabola.
D000747:Anemia, Hypochromic / Q000097:blood* / Q000150:complications; D006454:Hemoglobins / Q000032:analysis*; D006801:Humans; D012044:Regression Analysis; D013789:Thalassemia / Q000097:blood* / Q000150:complications
D006454:Hemoglobins