GLC determination of paracetamol and d-propoxyphene.
d-Propoxyphene and d-norpropoxyphene were determined in rat plasms, rat brain homogenates and human plasma by means of GLC utilizing extracts obtained by micro-phase extraction of the drugs. Paracetamol was determined in the same samples by GLC separation of the O-butyrate derivative using caffeine as internal standard. The problems associated with the GLC determination of d-propoxyphene and d-norpropoxyphene in biological material are discussed and attention is drawn to the particular advantages of the micro-phase extraction procedure for the quantitative determination of these drugs.
D000082:Acetaminophen / Q000032:analysis* / Q000097:blood; D000818:Animals; D001923:Brain Chemistry; D002849:Chromatography, Gas / Q000379:methods*; D011431:Dextropropoxyphene / Q000031:analogs & derivatives / Q000032:analysis* / Q000097:blood; D006801:Humans; D008297:Male; D051381:Rats
D000082:Acetaminophen; D011431:Dextropropoxyphene