Inhibition of ADP-induced platelet aggregation as a possible test for evaluation of the enterotoxigenicity of some enterobacteria. Preliminary study.
Some culture filtrates or enterotoxin preparations from enterobacteria that activate the adenylate cyclase system (vibrio cholerae, LT fraction from escherichia coli and klebsiella pneumoniae, shigella dysenteriae type 1) exibit an inhibiting effect on ADP-induced platelet aggregation, while other enterotoxin preparations not effective on adenylate cyclase system, don't interfere with this model. The A. propose the platelet aggregation as cellular assay to detect enterotoxin fractions effective upon adenylate cyclase system.
D000244:Adenosine Diphosphate / Q000494:pharmacology; D004755:Enterobacteriaceae / Q000472:pathogenicity*; D004768:Enterotoxins; D010974:Platelet Aggregation / Q000187:drug effects*
D004768:Enterotoxins; D000244:Adenosine Diphosphate
L'inibizione dell'aggregazione plastrinica da ADP come possibile test di valutazione dell'enterotossigenicta' di alcuni enterobatteri. Studio preliminare.