Relationship between the inhibitory activity on 'RCS' and prostaglandins synthesis and the anti-inflammatory activity of ketoprofen and several other non-steroidal anti-inflammatory agents.
In this study ketoprofen has been shown to be the most potent of all anti-inflammatory drugs in inhibiting the synthesis of prostaglandins and the 'rabbit-aorta contracting substance' (RCS), using the guinea-pig lung preparation. Although there did not appear to be a close relationship between the activities of the various drugs in inhibiting prostaglandins synthesis and in their anti-inflammatory activity, the compounds were ranked in the same order in both test systems.
D000038:Abscess / Q000188:drug therapy; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology*; D001011:Aorta / Q000187:drug effects; D001095:Arachidonic Acids / Q000378:metabolism; D001241:Aspirin / Q000494:pharmacology; D001577:Benzophenones / Q000494:pharmacology*; D003106:Colon / Q000187:drug effects; D006168:Guinea Pigs; D006880:Hydroxy Acids / Q000096:biosynthesis*; D007052:Ibuprofen / Q000494:pharmacology; D066298:In Vitro Techniques; D007213:Indomethacin / Q000494:pharmacology; D007660:Ketoprofen / Q000494:pharmacology* / Q000627:therapeutic use; D008168:Lung / Q000378:metabolism; D009119:Muscle Contraction / Q000187:drug effects; D009288:Naproxen / Q000494:pharmacology; D010653:Phenylbutazone / Q000494:pharmacology; D011448:Prostaglandin Antagonists / Q000494:pharmacology*; D011453:Prostaglandins / Q000096:biosynthesis*; D011714:Pyrans / Q000096:biosynthesis*
D000893:Anti-Inflammatory Agents; D001095:Arachidonic Acids; D001577:Benzophenones; D006880:Hydroxy Acids; D011448:Prostaglandin Antagonists; D011453:Prostaglandins; D011714:Pyrans; D009288:Naproxen; D007660:Ketoprofen; D010653:Phenylbutazone; D001241:Aspirin; D007052:Ibuprofen; D007213:Indomethacin