[Study of the effect of tetracycline, prodigiosin and their combination on the dynamics of phagocytosis of plague bacteria].
The advantage of the combined use of prodigiozan and tetracycline was observed in tissue culture of peritoneal macrophages of albino mice. Earlier digestion of the intracellular Y. pestis EV by the animal macrophages exposed to prodigiozan and treated with tetracycline was noted. It was shown that the macrophages preserved during several hours of cultivation in vitro their properties acquired in the animal organism under the effect of the substances administered.
D000818:Animals; D046508:Culture Techniques; D004338:Drug Combinations; D008264:Macrophages / Q000276:immunology; D051379:Mice; D010587:Phagocytosis / Q000187:drug effects*; D010930:Plague / Q000382:microbiology; D011353:Prodigiosin / Q000008:administration & dosage / Q000494:pharmacology*; D013752:Tetracycline / Q000008:administration & dosage / Q000494:pharmacology*; D015010:Yersinia pestis / Q000187:drug effects*
D004338:Drug Combinations; D013752:Tetracycline; D011353:Prodigiosin
Izuchenie vliianiia tetratsiklina, prodigiozana i ikh sochetaniia na dinamiku fagotsitoza chumnykh bakteriĭ