[Characteristics of the antivitamin effect of pyriditol, a disulfide pyridoxine derivative, on animal body].
Intraperitoneal administration of disulphide pyridoxine (pyriditol) to albino mice in a dose of 300 mg/kg brings down the GABA level and the GABA-transaminase activity in the brain, the glutamic acid content and the glutamate-decarboxylase activity remaining unchanged. In the liver and, especially, in the kidneys of test animals the activity of aspartate-and alanine-aminotransferase goes down. The diurnal urinary output of the animals shows a decreased passage of 4-pyridoxic acid. These results are interpreted to be consequent upon the antivitamin action of pyriditol with respect to pyridoxine.
D000612:4-Aminobutyrate Transaminase / Q000378:metabolism; D000410:Alanine Transaminase / Q000378:metabolism; D000818:Animals; D001219:Aspartate Aminotransferases / Q000378:metabolism; D001921:Brain / Q000378:metabolism; D005968:Glutamate Decarboxylase / Q000378:metabolism; D005971:Glutamates / Q000378:metabolism; D007274:Injections, Intraperitoneal; D007668:Kidney / Q000378:metabolism; D008099:Liver / Q000378:metabolism; D051379:Mice; D009206:Myocardium / Q000378:metabolism; D011725:Pyridines / Q000494:pharmacology*; D011735:Pyridoxic Acid / Q000652:urine; D011736:Pyridoxine / Q000037:antagonists & inhibitors*; D011746:Pyrithioxin / Q000008:administration & dosage / Q000031:analogs & derivatives / Q000494:pharmacology*; D005680:gamma-Aminobutyric Acid / Q000378:metabolism
D005971:Glutamates; D011725:Pyridines; D005680:gamma-Aminobutyric Acid; D011735:Pyridoxic Acid; D011746:Pyrithioxin; D001219:Aspartate Aminotransferases; D000612:4-Aminobutyrate Transaminase; D000410:Alanine Transaminase; D005968:Glutamate Decarboxylase; D011736:Pyridoxine
Kharakteristika antivitaminnogo deĭstviia disul'fidnogo proizvodnogo piridoksina-piriditola-na zhivotnyi organizm