[Distribution and depletion with time of retinol-C14 in different tissues and organs of albino rats].
Albino male rats of Wistar strain, weighing about 350 g., were administered orally a single dose of 2,50 mu C of retinol-C14 after a fast of 24 h. At intervals of 3 h and of 3, 6, 12, 18 and 24 days rats were killed; livers, kidneys, blood, white fat tissue and brown fat tissue were removed. Samples were dried and radioactivity was measured. From the results, expressed in mu C/g of dry tissue, it is clear that vitamin A is taken up by all tissues. After 3 days it decreases in all tissues, between the 3rd and 18th day, its rate is constant and the depletion is complete within 24 days.
D000818:Animals; D008297:Male; D051381:Rats; D013997:Time Factors; D014018:Tissue Distribution; D014801:Vitamin A / Q000378:metabolism*
D014801:Vitamin A
Distribuzione e deplezione nel tempo di retinolol-C14 in differenti tessuti ed organi di ratti albini.