title: [Pathologicoanatomic and enzymatic histochemical changes in the body of white rats with chronic, intermittent pirimor pesticide poisoning].
abstract: Not infrequently, the continuous use of pesticides leads to production of resistant species of agricultural pests which makes imperative to adopt the practice of intermittent, i. e. periodic application of the agricultural preparations. In this work the difference in degree of pathoanatomical damage upon chronic and periodic, weekly application of the new carbamide pesticide Pyrimor, extensively used in the Bulgarian farming economy, is discussed. The results of pathomorphological and histochemical study of the chief parenchymatous organs shows a clearcut difference in the group with continuous administration of the pesticide, as compared to the control and intermittently poisoned group. It is furthermore pointed out that the two-times higher dose, introduced at weekly intervals, leads to slighter lesions of parenchymatous organs in comparison with chronic, oral Pyrimor treatment. Season related, incessant use of pesticides results in occupational risk increase among the workers engaged in farming.
mesh_terms: D000818:Animals; D001921:Brain / Q000187:drug effects; D002219:Carbamates; D002908:Chronic Disease; D004305:Dose-Response Relationship, Drug; D004789:Enzyme Activation / Q000187:drug effects; D005260:Female; D006321:Heart / Q000187:drug effects; D007306:Insecticides / Q000506:poisoning*; D007668:Kidney / Q000187:drug effects; D008099:Liver / Q000187:drug effects; D008168:Lung / Q000187:drug effects; D008297:Male; D011743:Pyrimidines / Q000506:poisoning; D051381:Rats; D013737:Testis / Q000187:drug effects; D013997:Time Factors
chemical_list: D002219:Carbamates; D007306:Insecticides; D011743:Pyrimidines; C011994:pirimicarb
vernacular_title: Pathologoanatomichni i enzimokhistokhimichni promeni v organizma na beli plukhove pri khronichna intermitirashta intoksikatsiia s pestitsida pirimor.