Differences in cytochrome P-450 of various strains of rats following chronic administration of pentobarbital.
Cytochrome P-450 levels were analyzed in rats of two pigmented (black Long-Evans and ACI) and two albino strains (Fischer 344 and Sprague-Dawley) following the administration of pentobarbital sodium and physiological saline. Differences between the albino vs pigmented strains were observed following injections of saline. The Fischer 344 albino strains responded similarly to the pigmented strains following a progressively increasing dose schedule of pentobarbital sodium.
D000818:Animals; D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism*; D008099:Liver / Q000187:drug effects / Q000201:enzymology*; D008297:Male; D010424:Pentobarbital / Q000494:pharmacology*; D051381:Rats; D011912:Rats, Inbred ACI; D011916:Rats, Inbred F344; D011919:Rats, Inbred Strains; D013045:Species Specificity
D003577:Cytochrome P-450 Enzyme System; D010424:Pentobarbital