[Effect of reserpine, octadine and methyldopa on the distribution of cardiac output in hypertension].
Tests conducted on anesthetized rats with experimental renal hypertension demonstrated that octadine, reserpine and methyl-DOPA with their one-time administration produce at the onset of the maximal hypotensine effect of fall of the arterial pressure at the expense of the lowered total peripheral resistance. Most characteristic of the action exercised by these drugs is an increased fraction of the cardiac ejection going to the gestro-intestinal tract. In hypertension all the substances under study reduce the coronary and splenic fractions of the cardiac ejection. Reserpine and methyl-DOPA do not change, while octadine reduces the fraction of the cardiac ejection that goes to the kidney.
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D002302:Cardiac Output / Q000187:drug effects*; D006145:Guanethidine / Q000494:pharmacology*; D006977:Hypertension, Renal / Q000503:physiopathology*; D008297:Male; D008750:Methyldopa / Q000494:pharmacology*; D051381:Rats; D012110:Reserpine / Q000494:pharmacology*; D014655:Vascular Resistance / Q000187:drug effects
D008750:Methyldopa; D012110:Reserpine; D006145:Guanethidine
O vliianii rezerpina, oktadina i metil-dofa na raspredelenie serdechnogo vybrosa v usloviiakh gipertonii.