[Effect of 4-amidinophenylpyruvic acid on the generalized Sanarelli-Shwartzman phenomenon].
The influence of 4-amidinophenylpyruvic acid (APPA)--a synthetic thrombin inhibitor--on the incidence of disseminated intravascular coagulation was tested with the aid of a model of the generalized Sanarelli-Schwarzman phenomenon. After application of APPA the thrombogenesis in different organs subsided quite significantly.
D000311:Adrenal Glands / Q000098:blood supply; D000578:Amidines / Q000494:pharmacology / Q000627:therapeutic use; D000818:Animals; D000925:Anticoagulants / Q000494:pharmacology / Q000627:therapeutic use*; D001772:Blood Cell Count; D001792:Blood Platelets / Q000473:pathology; D004211:Disseminated Intravascular Coagulation / Q000097:blood / Q000188:drug therapy*; D005340:Fibrinogen / Q000037:antagonists & inhibitors; D007668:Kidney / Q000098:blood supply; D008099:Liver / Q000098:blood supply; D010667:Phenylpyruvic Acids / Q000494:pharmacology / Q000627:therapeutic use*; D011817:Rabbits; D012790:Shwartzman Phenomenon / Q000097:blood / Q000188:drug therapy*; D013917:Thrombin / Q000037:antagonists & inhibitors; D013927:Thrombosis / Q000097:blood / Q000188:drug therapy
D000578:Amidines; D000925:Anticoagulants; D010667:Phenylpyruvic Acids; D005340:Fibrinogen; D013917:Thrombin
Vliianie 4-amidinofenilpirovinogradnoĭ kisloty na generalizovannyĭ fenomen Sanarelli-Shvarttsmana.