Effect of angiotensin on the central action of dopamine.
Angiotensin given intraventricularly enhances amphetamine but not apomorphine-induced stereotypy 30 min. after peptide administration. Simultaneous injection of angiotensin and dopamine increases amphetamine -- while decreases apomorphine -- induced stereotypy. The stereotypy produced either by apomorphine or amphetamine in rats pretreated with Ro 4-4602 + L-DOPA was diminished by angiotensin. Angiotensin elevated haloperidol-induced catalepsy. A possibility that angiotensin may inhibit both release and uptake of dopamine by nerve endings is discussed.
D000661:Amphetamine / Q000494:pharmacology; D000804:Angiotensin II / Q000494:pharmacology*; D000818:Animals; D001058:Apomorphine / Q000494:pharmacology; D001545:Benserazide / Q000494:pharmacology; D002375:Catalepsy / Q000139:chemically induced / Q000503:physiopathology; D004298:Dopamine / Q000494:pharmacology / Q000502:physiology*; D004347:Drug Interactions; D005260:Female; D006220:Haloperidol / Q000494:pharmacology; D006801:Humans; D007980:Levodopa / Q000494:pharmacology; D008297:Male; D051381:Rats; D013239:Stereotyped Behavior / Q000187:drug effects; D013997:Time Factors
D000804:Angiotensin II; D007980:Levodopa; D001545:Benserazide; D000661:Amphetamine; D006220:Haloperidol; D001058:Apomorphine; D004298:Dopamine