[Effect of synthetic tetradecapeptide corresponding to 31-44 amino acid sequence of growth hormone on lipolysis in human adipose tissue].
Fat mobilyzing activity of synthetic tetradecapeptide, which corresponds in 31--44 amino acid sequence of human growth hormone, is studied in vitro in human fat tissue. The peptide at concentrations of 3--33 microng/ml considerably stimulated lipolysis in subdermal fat tissue, omentum and shoulder ateroma. Minimal efficient peptide concentration was 3 microng/ml in most experiments, sometimes it was 0.3 microng/ml. Direct dependency between dose logarithm and lipolysis rate was observed at dose interval of 0.3--18 microng/ml. Native growth hormone produced no activity in human fat tissue even in concentrations of 50--100 microng/ml.
D000273:Adipose Tissue / Q000187:drug effects / Q000378:metabolism*; D004305:Dose-Response Relationship, Drug; D013006:Growth Hormone / Q000494:pharmacology*; D006801:Humans; D050356:Lipid Metabolism; D008053:Lipid Mobilization / Q000187:drug effects; D010446:Peptide Fragments / Q000494:pharmacology*
D010446:Peptide Fragments; D013006:Growth Hormone
Vliianie sinteticheskogo tetradekapeptida, sootvetstvuiushchego aminokislotnoĭ posledovatel'nosti 31--44 gormona rosta cheloveka, na lipoliz v zhirovoĭ tkani cheloveka