[Comparison of lung-mechanical and physico-chemical Parameters in view of the pulmonary surfactant system (author's transl)].
Evaluation of static pressure-volume-diagram of lungs and of surface-tension-area-diagram of lung-elutions measured on the Lamgmuir-balance is tested. Well known parameters are used to characterize alveolar surfactant activity in guinea pigs after perbronchial application of extracorporal surfactant Tacholiquin and detergent "Fit" 1% and after application of vagomimetics Acetylcholine 1% and Histamine 0.1%. Mean values of physico-chemical parameters show the most significant increase of the area of hysteresis (Benzer) during Tacholiquin and Acetylcholin application; the minimal surface-tension: gamma min, and the compressibility-index: gamma min/delta gamma (Kötter, Rüffer) decreased, the difference between maximal and minimal surface-tension: delta gamma and the stability-index: 2 delta gamma/(gamma max + gamma min) (Clements) increased. Tacholiquin and Acetylcholin both improve pulmonary surface-activity. The Tacholiquin-effect is documented in lung mechanics only by elevation of the inspiratory volume-rations: V10I/V20I (Clements) and V10I/Vmax (Kittelmann) referred to static pressure 10, 20 cm H2O and maximal pressure but not by elevation of the expiratory stability index V10E/Vmax (Gruenwald). The area of hysteresis is decreased indicating a preponderant inspiratory effect. The Acteylcholin-effect is covered by the well-known bronchial obstructive effect. Both inspiratory constants are decreased, and the area of hysteresis is increased. We did not find any significance of the expiratory stability index. Both inspiratory constants and the area of hysteresis are conditional surfactant parameters in view of bronchial obstruction.
D000109:Acetylcholine / Q000494:pharmacology; D000818:Animals; D003902:Detergents / Q000494:pharmacology; D006168:Guinea Pigs; D006632:Histamine / Q000494:pharmacology; D008168:Lung / Q000187:drug effects / Q000502:physiology*; D011663:Pulmonary Surfactants / Q000378:metabolism* / Q000494:pharmacology; D012129:Respiratory Function Tests; D013500:Surface Tension
D003902:Detergents; D011663:Pulmonary Surfactants; D006632:Histamine; D000109:Acetylcholine
Informationsgehalt atemmechanischer und physikochemischer parameter in bezug auf das Surfactantsystem der Lunge