Brain abscess caused by Cladosporium trichoides (Bantianum): a case with paranasal sinus involvement.
Dematiacious fungi (ie, fungi with dark hyphae) are a rare and usually fatal cause of central nervous system infection. Cladosporium trichoides has been implicated most frequently. Documentation of extra-CNS involvement has been rare. Our patient had a brain abscess and paranasal sinus infection due to C trichoides. The organism was sensitive to less than or equal 2mug/ml of flucytosine. Although our patient did not receive flucytosine, it is possible that this drug, because of its excellent penetration into the cerebrospinal fluid, may be a useful therapeutic agent in cerebral cladosporiosis.
D001922:Brain Abscess / Q000188:drug therapy / Q000209:etiology*; D002963:Cladosporium; D005437:Flucytosine / Q000627:therapeutic use; D006801:Humans; D008297:Male; D008875:Middle Aged; D003904:Mitosporic Fungi; D009181:Mycoses / Q000188:drug therapy; D012852:Sinusitis / Q000188:drug therapy
D005437:Flucytosine