[Damaging effect of 3H-uridine on tissue culture cells during the logarithmic and stationary phases of growth].
The Chinese hamster fibroblasts entered the stationary phase of growth after 5.5 days of cultivation. The induction of the culture proliferation occurred within the first 4 hrs of cultivation in the fresh nutrient medium. After addition of 3H-uridine in high concentration and with high specific activity (75 micron Cu/M and 23 Cu/mM), in the stationary phase a lesser number of cells with aberrations and a higher mitotic index were noted than in the logarithmic phase. 3H-uridine injured the cells in the stationary phase of growth but  to a lesser extent than those in the logarithmic phase, i. e. during the intensive RNA synthesis in cells.
D000818:Animals; D002478:Cells, Cultured; D002869:Chromosome Aberrations; D006224:Cricetinae; D005347:Fibroblasts; D008940:Mitotic Index; D012313:RNA / Q000096:biosynthesis*; D011833:Radiation Injuries, Experimental / Q000235:genetics / Q000503:physiopathology*; D014529:Uridine / Q000378:metabolism*
D012313:RNA; D014529:Uridine
Povrezhdaiushchee deistvie 3H-uridina na kletki kul'tury tkani v logarifmicheskoĭ i statsionarnoĭ fazakh rosta