Effects of reserpine on the responses of the isolated rat fundus strip to catecholamines and specific adrenoceptor antagonists.
The effects of reserpine on the sensitivity to catecholamines and adrenoceptor antagonists propranolol and azapetine were studied on the fundus strips of the rat. The results obtained in this study would support the view that reserpine may increase the sensitivity of beta receptor to isoprenaline and adrenaline by the mechanism which may be independent of the uptake of catecholamines in the sympathetic nervous system.
D000818:Animals; D002395:Catecholamines / Q000494:pharmacology*; D004347:Drug Interactions; D066298:In Vitro Techniques; D007545:Isoproterenol / Q000494:pharmacology; D008297:Male; D009119:Muscle Contraction / Q000187:drug effects; D009130:Muscle, Smooth / Q000187:drug effects; D011433:Propranolol / Q000494:pharmacology; D051381:Rats; D011941:Receptors, Adrenergic / Q000187:drug effects*; D012110:Reserpine / Q000494:pharmacology*; D013270:Stomach / Q000187:drug effects*
D002395:Catecholamines; D011941:Receptors, Adrenergic; D012110:Reserpine; D011433:Propranolol; D007545:Isoproterenol