Recurrence risks for retinoblastoma: a model for autosomal dominant disorders with complex inheritance.
The characteristics of retinoblastoma pertinent to genetic counseling are presented. Vogel's model for the inheritance pattern of the tumor is described and then used to derive recurrence risks for the important genetic counseling situations in retinoblastoma. The effect on the risk of the degree and number of unaffected relatives to the index case in a pedigree is quantified.
D002675:Child, Preschool; D005134:Eye Neoplasms / Q000235:genetics*; D005799:Genes, Dominant; D005817:Genetic Counseling; D006801:Humans; D008954:Models, Biological; D010375:Pedigree; D012175:Retinoblastoma / Q000235:genetics*; D012306:Risk