Effect of the interferon inducer tilorone in inbred CBA mice.
Tilorone hydrochloride (200 mg/kg) was administered intragastrically to inbred CBA mice. After 5, 18 and 48 hr the number of circulating leucocytes and peritoneal cells as well as the migration of unstimulated peritoneal cells, the blood corticosteroid level and interferon production were investigated. In spite of the considerable decrease of the number of mononuclear cells in the blood and polynuclear ones in the peritoneal exudate, the drug induced production of circulating interferon and stimulated its synthesis by peritoneal cells. The blood corticosteroid level and the mast cell count in the peritoneal cavity were significantly elevated, but the migration of peritoneal cells in antigen-free medium decreased.
D000284:Administration, Oral; D000305:Adrenal Cortex Hormones / Q000097:blood; D000818:Animals; D001202:Ascitic Fluid / Q000166:cytology; D002452:Cell Count; D002464:Cell Migration Inhibition; D005449:Fluorenes / Q000494:pharmacology*; D007372:Interferons / Q000096:biosynthesis* / Q000097:blood; D007958:Leukocyte Count; D007962:Leukocytes / Q000187:drug effects; D008264:Macrophages / Q000187:drug effects; D008297:Male; D008407:Mast Cells / Q000187:drug effects; D051379:Mice; D008808:Mice, Inbred CBA; D013994:Tilorone / Q000494:pharmacology*
D000305:Adrenal Cortex Hormones; D005449:Fluorenes; D007372:Interferons; D013994:Tilorone