[Effect of obsidan on the course of experimental myocardial infarct with arrhythmias in rabbits].
Experimental myocardial infarction (EMI) was reproduced in 35 of 40 rabbits operated upon. Ampouled obsidan was slowly introduced to 12 rabbits with EMI directly after ligation of the coronary arteries and once during each subsequent two days into the marginal otic vein. The results of the antiarrhythmic action of the drug were judged about from the data of a dynamic ECG-observation in 3 standard leads. From the information thus obtained it followed that a single administration of obsidan to rabbits in the acute period of EMI (the first 3 days of the experiment) prevented the development of complex disturbances of the rhythm and reduced the lethality rate among the animals. In repeated injections of the drug it is necessary to take account of the preceding arrhythmias. Reintroduction of obsidan to rabbits with EMI complicated by sinus bradycardia and ventricular extrasystole is prognostically dangerous (ventricular extrasystole relapses and its transformation into ventricular tachycardia is possible). At later stages of EMI these animals succumbod due to complex disturbances of the rhythm and conduction.
D000818:Animals; D000889:Anti-Arrhythmia Agents / Q000627:therapeutic use*; D001145:Arrhythmias, Cardiac / Q000453:epidemiology / Q000209:etiology / Q000517:prevention & control*; D004341:Drug Evaluation; D004562:Electrocardiography; D005260:Female; D008297:Male; D009203:Myocardial Infarction / Q000150:complications / Q000188:drug therapy*; D011433:Propranolol / Q000627:therapeutic use*; D011817:Rabbits
D000889:Anti-Arrhythmia Agents; D011433:Propranolol
K voprosu o vliianii obzidana na techenie eksperimental'nogo infarkta miokarda s aritmiiami u krolikov.