[Analgesic effects of Neurotropin in mice, and a comparison with analgesic effect of other drugs in SART-stressmice].
Analgesic effects of a neuroleptica "Neurotropin" (NSP) were studied in mice while the analgesic effects of other agents were studied in SART-stress mice (specific stress caused by alterating rhythm in temperature) and the results compared with those in normal mice. NSP is an extract containing many conjugated polysaccarides isolated from the skin or tissues of rabbits which had been inoculated with the living cowpox virus. (a) NSP given alone to normal mice resulted in slight analgesic effects as observed with the application of the acetic acid-, phenylquinon-writhing method or the modified Randall-Selitto method. Little effect was seen when the D'Amour-Smith was used. (b) Synergism was evident when NSP and aminopyrine or NSP and morphine were given concomitantly and the acetic acid- or phenylquinon-writhing methods were applied. (c) Analgesic effects of morphine, levomepromazine, imidazole acetic acid and particularly NSP were greater in SART-stress mice than in normal mice. With the D'Amour-Smith method, only NSP had a greater effect in SART-stress mice than in normal mice.
D000632:Aminopyrine / Q000627:therapeutic use; D000700:Analgesics / Q000627:therapeutic use*; D000818:Animals; D004357:Drug Synergism; D007093:Imidazoles / Q000627:therapeutic use; D008297:Male; D008728:Methotrimeprazine / Q000627:therapeutic use; D051379:Mice; D011134:Polysaccharides / Q000627:therapeutic use*; D013312:Stress, Physiological / Q000188:drug therapy* / Q000209:etiology; D013696:Temperature
D000700:Analgesics; D007093:Imidazoles; D011134:Polysaccharides; D000632:Aminopyrine; D008728:Methotrimeprazine