Effect of prolonged trifluoperazine, imipramine and haloperidol administration on serum cholesterol. An experimental study in rabbits.
As a result of prolonged intragastric administration of trifluoperazine (TFZ) and imipramine in rabbits, a significant rise in serum cholesterol was observed after 4, 8 and 12 weeks. Haloperidol was ineffective. Hypercholesterolemia produced by TFZ was not associated with increased estriol excretion in urine. Histochemical examination of aorta of TFZ-treated animals showed positive 'Schultz's reaction' for cholesterol, suggesting a possible causal relationship between TFZ-induced hypercholesterolemia and atherogenesis.
D000818:Animals; D001011:Aorta / Q000378:metabolism; D002784:Cholesterol / Q000097:blood* / Q000378:metabolism; D004964:Estriol / Q000652:urine; D006220:Haloperidol / Q000008:administration & dosage / Q000494:pharmacology*; D007099:Imipramine / Q000008:administration & dosage / Q000494:pharmacology*; D007267:Injections; D008297:Male; D011817:Rabbits; D013270:Stomach; D013997:Time Factors; D014268:Trifluoperazine / Q000008:administration & dosage / Q000494:pharmacology*
D014268:Trifluoperazine; D002784:Cholesterol; D004964:Estriol; D006220:Haloperidol; D007099:Imipramine