[Therapeutic-preventive effect of sodium selenite on the course of experimental myocardial infarct].
An occlusion of the left coronary artery in rats tends to signally raise the intensity of free radical oxidation of myocardial-lipids, which is revealed by the chemofluorescent method. A direct correlational link between the intensity of the lipids peroxidation and the extent of the myocardial damage was established. Subcutaneous injection of sodium selenite in a dose of 30 gamma/kg 2 hours prior to ligation and once daily for a space of 7 days produces a distincly reduced intensity of free-radical processes in the myocardium, decreases the extent of infarction and prevents the appearance of gross changes on the ECG.
D000818:Animals; D004341:Drug Evaluation; D004562:Electrocardiography; D005500:Follow-Up Studies; D005609:Free Radicals; D050356:Lipid Metabolism; D008297:Male; D009203:Myocardial Infarction / Q000188:drug therapy* / Q000378:metabolism / Q000517:prevention & control; D009206:Myocardium / Q000378:metabolism; D010084:Oxidation-Reduction; D051381:Rats; D012643:Selenium / Q000627:therapeutic use*
D005609:Free Radicals; D012643:Selenium
Lechebno-profilakticheskoe vliianie selenita natriia na techenie eksperimental'nogo infarkta miokarda.