[Toxicity and cumulative properties of carminomycin, rubomycin and adriamycin at different times of use].
LD50 of karminomycin, rubomycin and adriamycin were determined after their single administration or 3-, 5-, 10- and 15-fold administration once a day to 540 hybrid male mice F1(C57B1 X CBA). Comparison of the cumulative indices for these antibiotics showed that after injections they were close. After 5 injections the cumulative properties were more pronounced for adriamycin. After 10 or 15 injections the cumulative properties were less pronounced for karminomycin.
D000818:Animals; D000903:Antibiotics, Antineoplastic / Q000633:toxicity*; D002360:Carubicin / Q000008:administration & dosage / Q000633:toxicity*; D003630:Daunorubicin / Q000008:administration & dosage / Q000633:toxicity*; D004317:Doxorubicin / Q000008:administration & dosage / Q000633:toxicity*; D007928:Lethal Dose 50; D051379:Mice; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D013997:Time Factors
D000903:Antibiotics, Antineoplastic; D004317:Doxorubicin; D002360:Carubicin; D003630:Daunorubicin
Toksichnost' i kumuliativnye svoĭstva karminomitsina, rubomitsina i adriamitsina pri raznykh srokakh primeneniia