title: Sulphonylurea and hypothyroidism in Nigerian diabetic subjects.
abstract: Thyroid function has been assessed using the T3-Uptake test in 98 nigerian diabetic and 50 non-diabetic control subjects. Whilst abnormal tests suggestive of thyroidal hypofunctional state were commoner in the group on chlorpropamide alone, and in combination with metformin, these were unrelated to the duration of treatment. In addition, none had clinical hypothyroidism.
mesh_terms: D000293:Adolescent; D000328:Adult; D002747:Chlorpropamide / Q000009:adverse effects / Q000627:therapeutic use; D003920:Diabetes Mellitus / Q000188:drug therapy*; D006801:Humans; D007037:Hypothyroidism / Q000139:chemically induced*; D007328:Insulin / Q000627:therapeutic use; D008687:Metformin / Q000627:therapeutic use; D008875:Middle Aged; D009549:Nigeria; D013453:Sulfonylurea Compounds / Q000009:adverse effects*; D013960:Thyroid Function Tests
chemical_list: D007328:Insulin; D013453:Sulfonylurea Compounds; D008687:Metformin; D002747:Chlorpropamide