Clinical and experimental studies on the action of prostaglandins and their synthesis inhibitors on detrusor muscle in vitro and in vivo.
Experiments on muscle strips have shown that prostaglandin is naturally produced by the detrusor, and acts to increase the tone and spontaneous activity. An intimate relation between acetylcholine and prostaglandin has been demonstrated. Therapeutic application of prostaglandins has been successful in the treatment of chronic retention in women.
D000818:Animals; D002415:Cats; D004285:Dogs; D004305:Dose-Response Relationship, Drug; D005260:Female; D006168:Guinea Pigs; D006801:Humans; D066298:In Vitro Techniques; D009119:Muscle Contraction / Q000187:drug effects*; D011448:Prostaglandin Antagonists / Q000494:pharmacology*; D011458:Prostaglandins E / Q000494:pharmacology* / Q000627:therapeutic use; D011460:Prostaglandins F / Q000494:pharmacology*; D011817:Rabbits; D051381:Rats; D012756:Sheep; D001743:Urinary Bladder / Q000187:drug effects; D014555:Urination Disorders / Q000188:drug therapy
D011448:Prostaglandin Antagonists; D011458:Prostaglandins E; D011460:Prostaglandins F