[Influence of antidepressants on the convulsive action of corazole and strychnine].
The influence of 10 antidepressants on an experimentally induced convulsive syndrome in mice was studied. It was found that, as concerns their ability to have an effect on DL50 of metrasol, the depressants may be classified into drugs protecting mice against the action of metrasol (melipramine, amitryptiline, chlorprothixen and phthoracizine), those potentiating the effect of metrasol (insidon, phrenolon, iproniazide, nuredal) and drugs producing no essential effect on DL50 of metrasol (desipramine, sonapax). All of the above drugs had an effect of decreasing the mean lethal dose of strychnine.
D000818:Animals; D000927:Anticonvulsants; D000928:Antidepressive Agents; D003292:Convulsants; D004347:Drug Interactions; D051379:Mice; D010433:Pentylenetetrazole / Q000037:antagonists & inhibitors; D012640:Seizures / Q000139:chemically induced*; D013331:Strychnine / Q000037:antagonists & inhibitors
D000927:Anticonvulsants; D000928:Antidepressive Agents; D003292:Convulsants; D013331:Strychnine; D010433:Pentylenetetrazole
Vliianie antidepressantov na sudorozhnoe deĭstvie korazola i strikhnina