Host resistance to a spontaneously metastasising melanoma after primary tumour excision.
Tumour resistance was investigated in a spontaneously metastasising murine melanoma. Specific tumour resistance was found in mice with intact small primary tumours and no metastases. If primary tumours were excised, resistance was demonstrated in mice which had metastases and in mice which did not have metastases but were given crude melanoma homogenate. No resistance could be detected in mice which had large primary tumours left intact or in mice which had small primary tumours excised four days prior to tumour challenge. These in vivo findings are compared with previously documented in vitro results.
D000008:Abdominal Neoplasms / Q000473:pathology; D000818:Animals; D005260:Female; D006614:Hindlimb / Q000601:surgery; D007109:Immunity; D008545:Melanoma / Q000276:immunology* / Q000473:pathology / Q000601:surgery; D051379:Mice; D008810:Mice, Inbred C57BL; D009362:Neoplasm Metastasis; D009368:Neoplasm Transplantation; D009374:Neoplasms, Experimental; D014184:Transplantation, Homologous