title: The effect of splenectomy on circulatory adjustments to hypoxaemia in the anaesthetized dog.
abstract: Six intact and seven splenectomized dogs were subjected to a similar degree of hypoxaemia while under light anaesthesia and artificial ventilation. In the intact animals, heart rate, cardiac output, myocardial contractility and oxygen consumption were increased as a result of hypoxaemia; oxygen transport was not affected. In the splenectomized animals the changes in cardiac output and myocardial contractility were small, and oxygen availability was decreased.
mesh_terms: D000777:Anesthetics / Q000494:pharmacology; D000818:Animals; D001692:Biological Transport / Q000187:drug effects; D002302:Cardiac Output / Q000187:drug effects; D004285:Dogs; D006339:Heart Rate / Q000187:drug effects; D006439:Hemodynamics / Q000187:drug effects*; D000860:Hypoxia / Q000503:physiopathology*; D009200:Myocardial Contraction / Q000187:drug effects; D010101:Oxygen Consumption / Q000187:drug effects; D012121:Respiration, Artificial; D013156:Splenectomy
chemical_list: D000777:Anesthetics