title: Changes in cell age cohort composition of tumors and normal tissues by radiation and chemotherapy.
abstract: The cell cycle is now known to be important in normal and tumor tissue and to be altered by a variety of states and therapies. The fact that there is considerable normal variation in cell ages or age cohorts present in both normal and tumor tissues has only recently been widely appreciated. These differ in normal, malignant, young and adult tissues. They are also greatly perturbed by radiation or chemotherapeutic injury. How to combine multi-modality therapy to optimize tumor control using available agents while sparing normal tissues is a problem for the future of cancer therapy and radiation oncology.
mesh_terms: D000818:Animals; D002470:Cell Survival / Q000187:drug effects / Q000528:radiation effects; D002471:Cell Transformation, Neoplastic / Q000187:drug effects / Q000188:drug therapy / Q000528:radiation effects*; D005472:Fluorouracil / Q000494:pharmacology / Q000627:therapeutic use; D006918:Hydroxyurea / Q000494:pharmacology / Q000627:therapeutic use; D051379:Mice; D013160:Splenic Neoplasms / Q000188:drug therapy / Q000532:radiotherapy; D013997:Time Factors
chemical_list: D005472:Fluorouracil; D006918:Hydroxyurea