[Liberation of H3-GABA from isolated nerve endings of the cerebral cortex of rats under the effect of psychotropic drugs].
The influence of a number of neuroleptics and antidepressants on the release of 3H-GABA from the synaptosomas of the cerebral cortex in rats was studied. Chlorpromazine, phthorphenazine, trifluperidol, imipramine, phthoracizine caused an intensified liberation of 3H-GABA from the synaptosomas. In this phenothiazine neuroleptics proved more active than did trifluperidol and antidepressants. New neuroleptics--azabuperon and carbidine and also diphenylhydantoin tended to restrict the liberation of the mediator from synaptosomas. The tranquilizer diazepam, gamma-oxybutyric acid and carbamazepine failed to have any significnat effect on this process. The described effects of thepsychotropic substances are due, apparently, to their direct influence on the synaptomal membrane.
D000613:Aminobutyrates / Q000378:metabolism*; D000818:Animals; D000929:Antidepressive Agents, Tricyclic / Q000494:pharmacology*; D002220:Carbamazepine / Q000494:pharmacology; D002243:Carbolines / Q000494:pharmacology; D002540:Cerebral Cortex / Q000187:drug effects* / Q000378:metabolism; D002746:Chlorpromazine / Q000494:pharmacology; D046508:Culture Techniques; D003975:Diazepam / Q000494:pharmacology; D005476:Fluphenazine / Q000494:pharmacology; D007099:Imipramine / Q000494:pharmacology; D010640:Phenothiazines / Q000494:pharmacology; D010672:Phenytoin / Q000494:pharmacology; D011188:Potassium / Q000494:pharmacology; D051381:Rats; D012964:Sodium / Q000494:pharmacology; D013574:Synaptosomes / Q000378:metabolism*; D014149:Tranquilizing Agents / Q000494:pharmacology*; D014272:Trifluperidol / Q000494:pharmacology; D014316:Tritium; D005680:gamma-Aminobutyric Acid / Q000031:analogs & derivatives / Q000378:metabolism* / Q000494:pharmacology
D000613:Aminobutyrates; D000929:Antidepressive Agents, Tricyclic; D002243:Carbolines; D010640:Phenothiazines; D014149:Tranquilizing Agents; D014316:Tritium; D002220:Carbamazepine; D005680:gamma-Aminobutyric Acid; D010672:Phenytoin; D012964:Sodium; D007099:Imipramine; D003975:Diazepam; D014272:Trifluperidol; D011188:Potassium; D005476:Fluphenazine; D002746:Chlorpromazine
Vysyobozhdenie 3H-GAMK iz izolirovannykh nervnykh oxonchaniĭ kory mozga krys pri beĭstvii pskhotropnyhk veshchestv.