title: Radiation sensitizing effect of diamide on human cells cultivated in vitro.
abstract: Human cells of line NHIK 3025 were irradiated suspended in growth medium (E2a) in absence and presence of diamide under aerobic and extremely hypoxic (less than 4 ppm O2) conditions. A sensitizing effect of diamide was found for doses exceeding 8 Gy (800 rad) on cells irradiated under extremely hypoxic conditions in presence of diamide of concentration 200 micrometer, whereas no significant effect was observed for 20 micrometer.
mesh_terms: D001391:Azo Compounds / Q000494:pharmacology*; D002455:Cell Division / Q000528:radiation effects*; D002460:Cell Line; D002470:Cell Survival / Q000528:radiation effects*; D003470:Culture Media; D003958:Diamide / Q000494:pharmacology*; D004307:Dose-Response Relationship, Radiation; D005947:Glucose / Q000378:metabolism; D006801:Humans; D000860:Hypoxia; D066298:In Vitro Techniques; D011836:Radiation Tolerance
chemical_list: D001391:Azo Compounds; D003470:Culture Media; D003958:Diamide; D005947:Glucose