Changes in glucoamylase activity under the influence of drugs affecting the adrenergic receptors in myocardium and skeletal muscle.
The activity of neutral glucoamylase and alpha-amylase were determined in the myocardium and skeletal muscle after in vivo pharmacologic stimulation of adrenergic receptors. The activity changes of these enzymes were found to not always occur parallelly. The activity of both these enzymes is decreased under beta-agonistic influence of isoprenaline, adrenaline, as well as under the influence of acetylcholine. On the other hand, alpha-agonistic function of phenylephrine mainly results in the increase of neutral glucoamylase activity. Similar effects are obtained by suprarenal ligation. The above pharmacological effects did not appear when the said pharmacologic drugs were added to incubated muscle extracts.
D000109:Acetylcholine / Q000494:pharmacology; D000311:Adrenal Glands / Q000502:physiology; D000681:Amylases / Q000378:metabolism*; D000818:Animals; D004837:Epinephrine / Q000494:pharmacology; D005959:Glucosidases / Q000378:metabolism*; D007545:Isoproterenol / Q000494:pharmacology; D008297:Male; D009132:Muscles / Q000201:enzymology*; D009206:Myocardium / Q000201:enzymology*; D010656:Phenylephrine / Q000494:pharmacology; D051381:Rats; D011941:Receptors, Adrenergic / Q000187:drug effects*; D013566:Sympathomimetics / Q000494:pharmacology*
D011941:Receptors, Adrenergic; D013566:Sympathomimetics; D010656:Phenylephrine; D000681:Amylases; D005959:Glucosidases; D007545:Isoproterenol; D000109:Acetylcholine; D004837:Epinephrine