title: Selective breeding of rats for differences in reactivity to alcohol. An approach to an animal model of alcoholism. I. General procedures.
abstract: Strains of rats are being developed which have distinct responses in spontaneous locomotor activity to a subhypnotic dose of alcohol. The purpose is to produce one strain in which the injection of a standard dose of alcohol will result in objectively measurable intoxication and a second in which an identical dose will result in virtually no effect.
mesh_terms: D000435:Alcoholic Intoxication; D000437:Alcoholism; D000818:Animals; D001947:Breeding; D004195:Disease Models, Animal; D004305:Dose-Response Relationship, Drug; D000431:Ethanol / Q000008:administration & dosage / Q000097:blood; D005260:Female; D006801:Humans; D007274:Injections, Intraperitoneal; D008297:Male; D009043:Motor Activity / Q000187:drug effects; D010641:Phenotype; D051381:Rats; D012641:Selection, Genetic; D013045:Species Specificity
chemical_list: D000431:Ethanol