title: Combined radiation-methotrexate therapy in preoperative management of carcinoma of the head and neck.
abstract: Fifty patients with primary carcinoma of the head and neck were treated preoperatively with 2,000 r and 500 mg/m2 of methotrexate. This combination reduces the tumor size in more than 90 per cent of patients, converts many of the tumors to a more manageable state, and appears to indicate that improved survival will occur.
mesh_terms: D002294:Carcinoma, Squamous Cell / Q000532:radiotherapy / Q000601:surgery / Q000628:therapy*; D006258:Head and Neck Neoplasms / Q000532:radiotherapy / Q000601:surgery / Q000628:therapy*; D006801:Humans; D008727:Methotrexate / Q000627:therapeutic use*; D011182:Postoperative Care; D011300:Preoperative Care; D011379:Prognosis
chemical_list: D008727:Methotrexate