[Effect of Bunaftine on the ventricular tachycardia due to aconitine in the dog].
Suppression of aconitine-induced ventricular tachycardia in the dog with various doses of Bunaftine was attempted. Stable re-establishment of the sinus rhythm was achieved in only 3/15 cases, whereas in 3 tachicardia was unchanged, and in 9 fibrillation appeared, due, it is thought, to the effect of the drug on myocardial conductivity, since fibrillation was the most frequent outcome when high doses were used.
D000157:Aconitine; D000818:Animals; D000889:Anti-Arrhythmia Agents / Q000494:pharmacology / Q000627:therapeutic use*; D002082:Butylamines / Q000494:pharmacology / Q000627:therapeutic use; D004195:Disease Models, Animal; D004285:Dogs; D009200:Myocardial Contraction / Q000187:drug effects; D009281:Naphthalenes / Q000494:pharmacology / Q000627:therapeutic use*; D013610:Tachycardia / Q000139:chemically induced / Q000188:drug therapy*
D000889:Anti-Arrhythmia Agents; D002082:Butylamines; D009281:Naphthalenes; D000157:Aconitine
Azione della bunaftine sulla tachicardia ventricolare da aconitina nel cane