[Preventive treatment with methylprednisolone and heparin in experimental trauma and hemorrhagic shock].
Twenty-six anesthesized mongrel dogs were subjected to a standardized traumatic hemorrhagic shock. Compared with the control group prophylactic treatment with high doses of methylprednisolone reduced functional and histologic alterations of the lung. Methylprednisolone in combination with heparin pretreatment prevents microthrombi but produces more alveolar bleeding.
D000818:Animals; D004285:Dogs; D006493:Heparin / Q000008:administration & dosage / Q000627:therapeutic use*; D008775:Methylprednisolone / Q000008:administration & dosage / Q000627:therapeutic use*; D012128:Respiratory Distress Syndrome / Q000517:prevention & control; D012771:Shock, Hemorrhagic / Q000188:drug therapy*; D014947:Wounds and Injuries / Q000150:complications*
D006493:Heparin; D008775:Methylprednisolone
Prophylaktische Therapie mit Methylprednisolon und Heparin bei experimentellem Trauma und hämorrhagischem Schock.