title: [Effect of monovalent cations on glutamate metabolism in rat brain].
abstract: Glutamate oxidation in vitro via deamination and transamination during gramicidin C-induced transport of K+ and Na+ in rat nervous tissue mitochondria was studied. An increase in ammonium production, i.e. in glutamate oxidation due to deamination, was shown to occur with maximal increase of oxygen consumption in the presence of cations. It was found that 1.5 mM Na+ activate oxygen consumption by 15% and accelerate ammonium production from glutamate (by 17%). No changes in aspartate production were observed. 15 mM K+ increase oxygen consumption by 29% and ammonium production by 11% during a decrease in aspartate production as compared to glutamate oxidation in the presence of a lower (10 mM) concentration of K+ in the samples.
mesh_terms: D000818:Animals; D001224:Aspartic Acid / Q000378:metabolism; D001921:Brain / Q000187:drug effects / Q000378:metabolism*; D003641:Deamination; D004305:Dose-Response Relationship, Drug; D005971:Glutamates / Q000378:metabolism*; D008928:Mitochondria / Q000378:metabolism; D010084:Oxidation-Reduction; D010101:Oxygen Consumption / Q000187:drug effects; D011188:Potassium / Q000494:pharmacology*; D000644:Quaternary Ammonium Compounds / Q000378:metabolism; D051381:Rats; D012964:Sodium / Q000494:pharmacology*
chemical_list: D005971:Glutamates; D000644:Quaternary Ammonium Compounds; D001224:Aspartic Acid; D012964:Sodium; D011188:Potassium
vernacular_title: Vliianie odnovalentnykh kationov na metabolizm glutamata v golovnom mozge krys