Ultrastructural changes produced in cultured, adriamycin-treated myocardial cells.
The ultrastructural evaluation of the early alterations adriamycin-induced on cultured mice heart cells is reported. The major effects are hypertrophy of the sarcoplasmic reticulum and a market increase of the number and total extension of the gap junctions. These findings are discussed in the light of the information available in the literature.
D001692:Biological Transport / Q000187:drug effects; D002462:Cell Membrane / Q000378:metabolism; D002478:Cells, Cultured; D003896:Desmosomes / Q000187:drug effects / Q000648:ultrastructure; D004317:Doxorubicin / Q000009:adverse effects* / Q000494:pharmacology; D006321:Heart / Q000187:drug effects*; D007365:Intercellular Junctions / Q000187:drug effects / Q000648:ultrastructure; D009206:Myocardium / Q000648:ultrastructure*; D012519:Sarcoplasmic Reticulum / Q000187:drug effects / Q000648:ultrastructure
D004317:Doxorubicin