The influence of adrenergic nerves of the response of blood vessels in the rabbit ear to 2--phenylalanine-8-lysine vasopressin (Octapressin).
The blood vessels in the rabbit ear have been used to investigate the effects of octapressin on vascular smooth muscle. Continuous administration of this drug resulted in tachphlatis. Cocaine enhanced the response of the ear to octapressin; however, this potentiation was not evident when phentolamine was concurrently added to the perfusate. Denervation and reserpinisation of the ear also eliminated the potentiation of octapressin's response by cocaine. The results suggest that there is a small, indirect sympathomimetic component involved in octapressin's action on the vasculature.
D000320:Adrenergic Fibers / Q000502:physiology*; D000818:Animals; D001158:Arteries / Q000187:drug effects; D003042:Cocaine / Q000494:pharmacology; D004431:Ear, External / Q000098:blood supply* / Q000294:innervation; D005259:Felypressin / Q000494:pharmacology*; D066298:In Vitro Techniques; D009130:Muscle, Smooth / Q000187:drug effects; D009526:Nialamide / Q000494:pharmacology; D010646:Phentolamine / Q000494:pharmacology; D011433:Propranolol / Q000494:pharmacology; D011817:Rabbits; D012110:Reserpine / Q000494:pharmacology; D012964:Sodium / Q000502:physiology; D013562:Sympathectomy; D014667:Vasopressins / Q000031:analogs & derivatives*; D014680:Veins / Q000187:drug effects
D014667:Vasopressins; D005259:Felypressin; D012110:Reserpine; D012964:Sodium; D011433:Propranolol; D003042:Cocaine; D009526:Nialamide; D010646:Phentolamine