Effects of d- and l-amphetamine on dorsal and ventral hypothalamic self-stimulation in three inbred strains of mice.
The effects of intraperitoneal injections of increasing doses of d- and l-amphetamine on self-stimulation behaviour in dorsal and ventral hypothalamic areas, were studied in BALB/c Orl., DBA/2 Orl, and C57BL/6 Orl inbred mice. Both isomers improved and disrupted self-stimulation as a function of the doses injected. However, the improvements obtained with d-amphetamine were higher than those obtained with 1-amphetamine. In contrast the 1 isomer generally provoked the highest disruptions. In addition, the three strains presented various sensitivities to d-amphetamine, which improved self-stimulation first in BALB/c (0.25 and 0.50 mg/kg), then in DBA/2 (0.50 and 1.0 mg/kg) and finally in C57BL/6 (2.0, 4.0 and 8.0 mg/kg). The dorsal hypothalamic self-stimulation system presented a greater sensitivity to d-amphetamine than the ventral system; while the two reward systems reacted identically to 1-amphetamine.  The differential effects observed are set into relationship with neurochemical data concerning the central catecholaminergic mechanisms.
D000662:Amphetamines / Q000494:pharmacology*; D000818:Animals; D003913:Dextroamphetamine / Q000494:pharmacology*; D004558:Electric Stimulation; D007031:Hypothalamus / Q000187:drug effects / Q000502:physiology* / Q000648:ultrastructure; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D008810:Mice, Inbred C57BL; D008811:Mice, Inbred DBA; D012653:Self Stimulation / Q000187:drug effects*; D013045:Species Specificity; D013237:Stereoisomerism; D013329:Structure-Activity Relationship
D000662:Amphetamines; D003913:Dextroamphetamine