[Activity of various enzymes of energy metabolism of the myocardium after neurogenic injury].
A 3-hour electrostimulation of the aortic arch in rabbits was followed by the exhastion of the tissue noradrenaline stores in the myocardium accompanied by increase in the activity of the glycolysis enzymes and of the enzyme limiting the process of the pentosophosphate route-G-6-PDH. The use of noradrenaline precursor - 1-DOPA restored the noradrenaline level in the myocardium completely after a 48-hour stimulation. Simultaneously there were noted no changes in the activity of the enzymes under study caused by the stimulation of the aortic arch. The data obtained confirmed the important role of the sympathetic nervous system and of its mediator - noradrenaline in the mechanism of the tissue metabolism regulation, whose derangement played a significant role in the development of dystrophic lesions of the heart tissue.
D000818:Animals; D001011:Aorta; D004558:Electric Stimulation; D004734:Energy Metabolism; D005954:Glucosephosphate Dehydrogenase / Q000378:metabolism*; D006321:Heart / Q000294:innervation; D006593:Hexokinase / Q000378:metabolism*; D007770:L-Lactate Dehydrogenase / Q000378:metabolism*; D007980:Levodopa / Q000494:pharmacology; D008297:Male; D009206:Myocardium / Q000378:metabolism*; D009638:Norepinephrine / Q000172:deficiency; D010429:Pentoses / Q000378:metabolism; D011817:Rabbits; D013564:Sympathetic Nervous System
D010429:Pentoses; D007980:Levodopa; D007770:L-Lactate Dehydrogenase; D005954:Glucosephosphate Dehydrogenase; D006593:Hexokinase; D009638:Norepinephrine
Aktivnost' nekotorykh fermentov energeticheskogo obmena miokarda pri ego neirogennom povrezhdenii.