New generalized equations for multiple dose kinetics by i.v. injection.
New generalized equations for one compartment open model system with rapid i.v. injections for multiple dose kinetics are developed. The model assumers the first order elimination. Equations are developed for the maximum and minimum amounts of drug in body after n and infinity number of doses. The methods for calculating rate of accumulation is presented and the relationship bewteen, f (fraction of drug present in the compartment at the time of repeated dosing), t1/2 and the dosing interval, tau.
D006207:Half-Life; D007275:Injections, Intravenous; D008433:Mathematics; D008954:Models, Biological; D004364:Pharmaceutical Preparations / Q000008:administration & dosage / Q000378:metabolism*
D004364:Pharmaceutical Preparations