Some aspects of the hepatic metabolism of ethrane.
From our studies of the rat we report observations on three aspects of the interaction of ethrane and liver. 1. Interaction of ethrane with cytochrome P450 in vitro. 2. The effect of ethrane administration on glutathione levels in vivo. 3. The effects of repeated ethrane administration in the absence and presence of microsomal enzymic induction on liver morphology. We conclude that ethrane has little or no propensity for damaging the liver.
D000818:Animals; D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism; D004737:Enflurane / Q000378:metabolism* / Q000494:pharmacology; D005978:Glutathione / Q000032:analysis; D066298:In Vitro Techniques; D008099:Liver / Q000032:analysis / Q000187:drug effects / Q000378:metabolism*; D008297:Male; D008738:Methyl Ethers / Q000378:metabolism*; D008862:Microsomes, Liver / Q000201:enzymology; D010634:Phenobarbital / Q000494:pharmacology; D051381:Rats
D008738:Methyl Ethers; D003577:Cytochrome P-450 Enzyme System; D004737:Enflurane; D005978:Glutathione; D010634:Phenobarbital