Studies on vasculitis. VII. C-reactive protein as a substance perpetuating chronic vasculitis. Occurrence in lesions and concentrations in sera.
Previous findings were confirmed that C-reactive protein (C-RP) occurs in some vasculitis lesions, particularly those infiltrated mainly by neutrophils (necrotizing vasculitis). The C-RP was usually in lesions also containing complement C1 or C3c, and in some, IgG was present. Using a procedure that reliably detected 200 ng C-RP/ml serum, C-RP was found in sera of many normal persons, and the amount was influenced by the occupation of the donor. Sera of thirty-one persons with vasculitis with mainly mononuclear cell-infiltrated lesions had about four-fold more C-RP (mean 28, 200 ng/ml serum) than found in normal persons, and sera of thirty-nine persons with mainly neutrophil-infiltrated lesions had eight times the normal amount (mean 56,400 ng C-RP/ml). The amount of C-RP was influenced by the severity, extent and duration of the disorder in most patients. Experimental data suggests that C-RP may contribute to the perpetuation of inflammation in chronic vasculitis.
D000818:Animals; D002097:C-Reactive Protein / Q000032:analysis*; D002908:Chronic Disease; D003172:Complement C1 / Q000378:metabolism; D003176:Complement C3 / Q000378:metabolism; D006801:Humans; D011695:IgA Vasculitis / Q000097:blood*; D007074:Immunoglobulin G / Q000378:metabolism; D009504:Neutrophils / Q000032:analysis; D011817:Rabbits; D012867:Skin
D003172:Complement C1; D003176:Complement C3; D007074:Immunoglobulin G; D002097:C-Reactive Protein