The role of the glucose-6-phosphate in the phosphorylase b kinase activation found in perfused rat hearts treated by dinitrophenol.
In order to explain the phosphorylase b kinase activation found in perfused rat hearts treated by dinitrophenol, the glucose-6-phosphate levels and the enzyme activity were determined. Experiments were also done to determine the phosphorylase b kinase inhibition by the ester. The low glucose-6-phosphate levels and the enzyme inhibition found, suggested that the phosphorylase b kinase is activated by a mechanism that involves phosphofructokinase.
D000818:Animals; D004140:Dinitrophenols / Q000494:pharmacology*; D005954:Glucosephosphate Dehydrogenase / Q000378:metabolism*; D006321:Heart / Q000187:drug effects; D007527:Isoenzymes / Q000378:metabolism; D009206:Myocardium / Q000201:enzymology*; D010477:Perfusion; D010764:Phosphorylase Kinase / Q000378:metabolism*; D051381:Rats
D004140:Dinitrophenols; D007527:Isoenzymes; D005954:Glucosephosphate Dehydrogenase; D010764:Phosphorylase Kinase