[Antiarrhythmic activity of trimecaine in experimental arrhythmia and its effect on the heart conduction system].
The anesthetic trimecaine is shown to be capable of eliminating the flutter of atria in dogs simulated by an electric stimulation of the myocardium and atrial fibrillation in cats induced with aconitin and precludes ventrical fibrillation in rats arising due to intoxication with calcium chloride. Trimecaine noticeably mitigates the toxic effect of strophanthin. While depressing the automatism of the sinoatrial node the drug does not affect the conduction function.
D000083:Acetanilides / Q000031:analogs & derivatives*; D000157:Aconitine; D000818:Animals; D000889:Anti-Arrhythmia Agents / Q000494:pharmacology / Q000627:therapeutic use*; D001281:Atrial Fibrillation / Q000139:chemically induced / Q000188:drug therapy*; D001282:Atrial Flutter / Q000139:chemically induced / Q000188:drug therapy*; D002122:Calcium Chloride / Q000009:adverse effects; D002415:Cats; D004285:Dogs; D004336:Drug Antagonism; D012849:Sinoatrial Node / Q000187:drug effects*; D013328:Strophanthins / Q000037:antagonists & inhibitors / Q000494:pharmacology / Q000633:toxicity; D014288:Trimecaine / Q000494:pharmacology / Q000627:therapeutic use*
D000083:Acetanilides; D000889:Anti-Arrhythmia Agents; D013328:Strophanthins; D014288:Trimecaine; D002122:Calcium Chloride; D000157:Aconitine
Protivoaritmicheskaia aktivnost' trimekaina pri eksperimental'nykh aritmiiakh i ego vliiani na provodiashchuiu sistemu serdtsa.