Hyperthermia in the treatment of bladder tumours.
High temperature bladder irrigation was employed in 4 men as an alternative to cystectomy because of their age and frailty. Hyperthermic irrigation of the bladder from 63 degree C for 70 minutes to 82 degree C for 25 minutes caused partial, but not total, necrosis of the bladder. Transitional cell carcinoma appears to be resistant in vivo, in some cases, to heating at temperatures that destroy adjacent normal structures. Hyperthermic irrigation of the bladder at these high temperatures may be hazardous. In view of these findings we cannot recommend high temperature bladder irrigation as an alternative to cystectomy even in poor risk patients.
D000368:Aged; D006358:Hot Temperature / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D009336:Necrosis; D007507:Therapeutic Irrigation; D001749:Urinary Bladder Neoplasms / Q000628:therapy*