Abetalipoproteinaemia. A case report with pathological studies.
The clinical and pathological features of a case of abetalipoproteinaemia in a 38-year-old patient are described in detail. A feature not previously recorded was a marked reduction in the velocity of ocular horizontal saccadic movements. Pathological studies revealed an active chronic demyelinating process. The patient showed no response to large doses of vitamin E. The rationale for this therapy, and the possible reasons for its failure are discussed.
D000012:Abetalipoproteinemia / Q000188:drug therapy / Q000473:pathology*; D000328:Adult; D003711:Demyelinating Diseases / Q000209:etiology*; D006801:Humans; D008297:Male; D009186:Myelin Sheath / Q000473:pathology; D013497:Sural Nerve / Q000473:pathology; D014794:Visual Fields; D014810:Vitamin E / Q000627:therapeutic use
D014810:Vitamin E