title: [Toxicologic evaluation of irradiated corn starch by long term experimentation with rats].
abstract: Maize starch pasteurized by irradiation was fed to OFA rats (Sprague Dawley derived) in an uncooked form (irradiated at 300 krad.) and in a cooked form (irradiated at 300 and 600 krad.) at dietary level of 62%. A six month toxicity trial was performed with uncooked starch and a 24 month trial with cooked starch. At the same time a reproduction study was conducted, over 3 generations with 2 litters per generation, using both uncooked and cooked irradiated starch. The parent generation (Fo) was randomly selected from animals in the feeding study and after the production of the F1a and F1b generations they were returned to that study. Control groups corresponding to each form of starch were established. They were fed the same diet except that the starch was not irradiated. The results of the various investigations conducted during the study (behavior, growth, mortality, haematology, serum biochemistry, histopathology) did not reveal any toxicological effect due to treatment, nor any effect on reproduction. No significant differences were shown between treated and control group.
mesh_terms: D000818:Animals; D001344:Autopsy; D001522:Behavior, Animal / Q000187:drug effects; D001772:Blood Cell Count; D001774:Blood Chemical Analysis; D004435:Eating / Q000187:drug effects; D005260:Female; D006128:Growth / Q000187:drug effects; D007422:Intestines / Q000382:microbiology; D008297:Male; D009929:Organ Size / Q000187:drug effects; D011247:Pregnancy; D051381:Rats; D011919:Rats, Inbred Strains; D012098:Reproduction / Q000187:drug effects; D013213:Starch / Q000528:radiation effects / Q000633:toxicity*; D013997:Time Factors; D003313:Zea mays
chemical_list: D013213:Starch
vernacular_title: Evaluation toxicologique de l'amidon de maïs irradié par expérimentation à long terme chez le rat