Lowering of blood acetaldehyde levels-a possible approach to prevention of alcoholic cardiomyopathy.
Based on the assumption that circulating acetaldehyde (AcH) is cardiotoxic, D-penicillamine was administered to dogs given alcohol orally, or given AcH intravenously. Paralleling the increase in plamsa norepinephrine (NE) and epinephrine (E) induced by AcH infusion, hemodynamic measurements showed a positive inotropic response with increase in pulse, blood pressure, left ventricular contractility, and cardiac output. Infusion of D-penicillamine abruptly lowered circulating levels of AcH and catecholamines, which was accompanied by an appropriate hemodynamic response.
D000079:Acetaldehyde / Q000097:blood*; D000437:Alcoholism / Q000150:complications* / Q000503:physiopathology; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D009202:Cardiomyopathies / Q000209:etiology / Q000503:physiopathology / Q000517:prevention & control*; D004195:Disease Models, Animal; D004285:Dogs; D004837:Epinephrine / Q000097:blood; D006801:Humans; D009638:Norepinephrine / Q000097:blood; D010396:Penicillamine / Q000494:pharmacology / Q000627:therapeutic use
D010396:Penicillamine; D000079:Acetaldehyde; D009638:Norepinephrine; D004837:Epinephrine