[Relationship between nephrotixic effect of gentamicin and streptomycin and their blood levels in laboratory animals].
A principle of studying the nephrotoxic properties of drugs under conditions of maintaining their constant levels in the blood and dynamic registration of the nitrogen levels in the urea followed by histological examination of the kidney is proposed. Correlation between the levels of gentamicin and streptomycin in the cat blood during 4-hour infusion and the level of the nephrotoxic effect was found, gentamicin being much more toxic than streptomycin.
D000818:Animals; D001806:Blood Urea Nitrogen; D002415:Cats; D004305:Dose-Response Relationship, Drug; D005260:Female; D005839:Gentamicins / Q000008:administration & dosage / Q000097:blood / Q000633:toxicity*; D007263:Infusions, Parenteral; D007684:Kidney Tubules / Q000187:drug effects* / Q000473:pathology; D008297:Male; D013307:Streptomycin / Q000008:administration & dosage / Q000097:blood / Q000633:toxicity*
D005839:Gentamicins; D013307:Streptomycin
O sviazi mezhdunefrotoksicheskim effedtom gentamitsina i streptomitsina i ikh kontsentratsieĭ v krovi podopytnykh zhivotnykh