[Nutritional effects in the rat of oxythioquinox (morestan) as a function of its concentration and of the lipid content of the diet].
Of two groups of rats, one received a normal diet and the other a high fat diet for 5 weeks. The effects of oxythioquinox, administred at diet concentration of 200, 400 and 800 mg/kg, of fresh food are studied on weight gain, food and calorie intake and on the weight and composition of various organs. Growth, food and calorie intake are diminished in relation to oxythioquinox concentration in the diet. There exist an interaction between the fat content of the diet and the toxicity of oxythioquinox. The decrease of the efficiency of calorie by oxythioquinox indicates a perturbation of the rats metabolism. An increase in the weight of the liver is observed with a significant interaction between the fat concentration and the oxythioquinox with the results expressed in weight of organ per 100 g body weight. There is an increase in the degree of the water content of the animals liver with normal fat diet. In the case of a high fat diet there is an increase of cholesterol and fatty acid content. In all case, the variations are more strongly marked in relation to the oxythioquinox concentration of the diet and at the same concentration, the high fat diet is more effective that the normal diet. There is an interaction between the lipids in the diet and the oxythioquinox and this interaction indicates, an accentuation of the effects of oxythioquinox by lipids of the diet.
D000818:Animals; D001835:Body Weight / Q000187:drug effects; D004041:Dietary Fats; D004347:Drug Interactions; D005659:Fungicides, Industrial / Q000633:toxicity*; D006128:Growth / Q000187:drug effects; D050356:Lipid Metabolism; D008099:Liver / Q000187:drug effects / Q000378:metabolism; D009929:Organ Size / Q000187:drug effects; D011810:Quinoxalines / Q000633:toxicity*; D051381:Rats
D004041:Dietary Fats; D005659:Fungicides, Industrial; D011810:Quinoxalines; C005266:quinomethionate
Effets nutritionnels, chez le rat, de l'oxythioquinox (morestan), en fonction de sa concentration et du taux de lipides du régime