title: [Effect of isosorbide dinitrate in relation to posture and age].
abstract: Rapid tilting into the 90 degrees upright position after 20 mg ISDN sublingually demonstrates a better orthostatic tolerance of the older group (in spite of a lower cardiac output) in comparison to the younger one. This can be explained by a higher tone of the resistance vessels and a stronger stretch resistance of the arteries of the elastic type (and probably of the veins), which are opposing the hydrostatic effects of orthostasis and guarantee a minor shifting of blood to the lower extremities. The increase of rigidity of the blood vessels with aging declares the better drug resistance of the older group but also points - on the other hand - to the borders of ISDN therapy.
mesh_terms: D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000368:Aged; D001794:Blood Pressure / Q000187:drug effects; D002302:Cardiac Output / Q000187:drug effects; D005260:Female; D006339:Heart Rate / Q000187:drug effects; D006439:Hemodynamics / Q000187:drug effects*; D006801:Humans; D007548:Isosorbide Dinitrate / Q000494:pharmacology*; D008297:Male; D008875:Middle Aged; D011187:Posture; D011674:Pulse; D014655:Vascular Resistance / Q000187:drug effects
chemical_list: D007548:Isosorbide Dinitrate
vernacular_title: Die Wirkung von Isosorbitdinitrat in Abhängigkeit von Körperlage und Lebensalter