[Changes in the lymphoid tissue and in the level of corticosteroids in staphylococcal intoxication and infection].
A complex quantitative study of changes of proliferative processes in lymphatic vessels on the one hand and changes of the level of corticosteroids in the peripheral blood in staphylococcal intoxication and infection in the same rats on the other hand has been carried out. In the work H3-thymidine has been used. The comparison of the obtained morphological data with the dynamics of the change in the corticosteroid level shows that the decay of lymphocytes, the devastating of light centers and the cortical substance of lymph nodes, an abrupt lowering of the amount of DNA-synthesizing and mitotically dividing cells take place in the period associated with a release of a great amount of corticosteroids into the blood. The drop of their level to control values goes in parallel with increasing the amount of DNA-synthesizing and mitotically dividing cells. The obtained data suggest that the leading role in those changes of the lympoid tissue which had been described by a number of authors in infectional processes is played by corticosteroids.
D015062:11-Hydroxycorticosteroids / Q000097:blood*; D001427:Bacterial Toxins / Q000008:administration & dosage; D008198:Lymph Nodes / Q000473:pathology*; D008214:Lymphocytes / Q000473:pathology; D013203:Staphylococcal Infections / Q000097:blood / Q000473:pathology*; D013210:Staphylococcus
D015062:11-Hydroxycorticosteroids; D001427:Bacterial Toxins
Izmeneiia limfoidnoĭ tkani i urovnia kortikosteroidov pri stafilokokkovoĭ intoksikatsii i infektsii