Prostaglandin in the saliva of the cattle tick Boophilus microplus.
Previous studies of saliva from engorged female cattle ticks revealed a component which induced contration of some isolated smooth muscles. Fractionation and further characterisation have shown that this substance is of the "slow-reacting" type, but that it is neither a bradykinin nor slow-reacting substance of anaphylaxis. The substance is deactivated by incubation with 15-hydroxprostaglandin dehydrogenase and its pharmacological properties also support its classification as a prostaglandin. A second pharmacologically-active component has now been found in the saliva but has not yet been characterised.
D000818:Animals; D001681:Biological Assay; D002850:Chromatography, Gel; D005260:Female; D007082:Ileum / Q000187:drug effects; D009130:Muscle, Smooth / Q000187:drug effects; D010862:Pilocarpine / Q000032:analysis; D011453:Prostaglandins / Q000032:analysis*; D012463:Saliva / Q000032:analysis*; D013270:Stomach / Q000187:drug effects; D013987:Ticks / Q000032:analysis*; D014599:Uterus / Q000187:drug effects
D011453:Prostaglandins; D010862:Pilocarpine