title: [Insufficiency of secretion from the exocrine pancreas in infants (excluding mucoviscidosis) Diagnosis and consequences].
abstract: The diagnosis of insufficiency of exocrine pancreatic secretion was made in two infants after demonstration of a marked decrease in the flow rate of enzyme secretions during the duodenal infusion of milk and after the IV injection of C.C.K.-P.Z. The two infants had a normal sweat test. One had pancreatic lipomatosis with neuropaenia, whilst the other had pancreatic deficiency which did not fall into the context of Shwachman's syndrome. This study suggests that the absence of exocrine pancreatic secretion is accompanied by multiple abnormalitites : decreased absorption of fats and vitamin B12 and, it would appear, variations in certain activities of the jejunal mucosa and decreased insulin stimulation from the intestine. Such a situation reflects the complexity of the relations established between the organs participating in the processes of absorption and digestion.
mesh_terms: D002648:Child; D002675:Child, Preschool; D003937:Diagnosis, Differential; D004041:Dietary Fats / Q000378:metabolism; D006801:Humans; D007223:Infant; D007441:Intubation, Gastrointestinal; D008286:Malabsorption Syndromes / Q000209:etiology*; D010179:Pancreas / Q000378:metabolism*; D010182:Pancreatic Diseases / Q000150:complications / Q000175:diagnosis / Q000378:metabolism; D010189:Pancreatic Juice / Q000378:metabolism*; D014805:Vitamin B 12 / Q000378:metabolism
chemical_list: D004041:Dietary Fats; D014805:Vitamin B 12
vernacular_title: Insuffisance de sécrétion du pancréas exocrine du nourrisson (en dehors de la mucoviscidose). Diagnostic et conséquences