title: Treatment of meningeal leukemia.
abstract: Chemotherapy via the intrathecal and intraventricular routes with the use of up to three drugs plus radiotherapy have produced remissions so prolonged that it is now practical to think of a "cure" rather than simple palliation of this disease. A promising treatment protocol is described in which radiotherapy is combined with and followed by intraventricular methotrexate and cytosine arabinoside.
mesh_terms: D002404:Catheterization; D002493:Central Nervous System Diseases; D002648:Child; D002675:Child, Preschool; D003561:Cytarabine / Q000008:administration & dosage; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D006854:Hydrocortisone / Q000008:administration & dosage; D007276:Injections, Intraventricular / Q000379:methods; D007278:Injections, Spinal; D007938:Leukemia / Q000188:drug therapy / Q000532:radiotherapy / Q000628:therapy*; D008727:Methotrexate / Q000008:administration & dosage / Q000134:cerebrospinal fluid
chemical_list: D003561:Cytarabine; D006854:Hydrocortisone; D008727:Methotrexate