Anti-ulcer activity of colloidal bismuth subcitrate in Shay-rats.
The anti-ulcer action of colloidal bismuth subcitrate (CBS) was tested in rats with a ligated pylorus (the Shay preparation). The liquid form used in the clinic displayed a dose-related inhibition of gastric ulceration. the recently developed solid form appeared to be just as effective. On the other hand, non-processed, non-colloidal bismuth salts and the CBS vehicle blank were completely inactive. The anti-ulcer activity of CBS was found to be unrelated to its buffering capacity.
D000818:Animals; D000897:Anti-Ulcer Agents; D001729:Bismuth / Q000008:administration & dosage / Q000494:pharmacology*; D002951:Citrates / Q000008:administration & dosage / Q000494:pharmacology; D003102:Colloids; D005260:Female; D051381:Rats; D011919:Rats, Inbred Strains; D012996:Solutions; D013276:Stomach Ulcer / Q000401:mortality / Q000473:pathology / Q000517:prevention & control; D013535:Suspensions; D014456:Ulcer / Q000517:prevention & control
D000897:Anti-Ulcer Agents; D002951:Citrates; D003102:Colloids; D012996:Solutions; D013535:Suspensions; D001729:Bismuth