Selective breeding of rats for differences in reactivity to alcohol. An approach to an animal model of alcoholism. I. General procedures.
Strains of rats are being developed which have distinct responses in spontaneous locomotor activity to a subhypnotic dose of alcohol. The purpose is to produce one strain in which the injection of a standard dose of alcohol will result in objectively measurable intoxication and a second in which an identical dose will result in virtually no effect.
D000435:Alcoholic Intoxication; D000437:Alcoholism; D000818:Animals; D001947:Breeding; D004195:Disease Models, Animal; D004305:Dose-Response Relationship, Drug; D000431:Ethanol / Q000008:administration & dosage / Q000097:blood; D005260:Female; D006801:Humans; D007274:Injections, Intraperitoneal; D008297:Male; D009043:Motor Activity / Q000187:drug effects; D010641:Phenotype; D051381:Rats; D012641:Selection, Genetic; D013045:Species Specificity
D000431:Ethanol