[Effect of polychlorocamphene on the organs and their neural apparatus in pregnant animals].
Experiments conducted on pregnant albino rats showed that in daily oral administration of polychlorokamphene--a chlorine organic compound widely used in agriculature--in a dose of 12 mg/kg (1/20 LD50) there was interrelation between the structural and the enzymatic changes in the nerve elements of the organs under study. They consisted in the focality of the affection of the nervous structures of the brain cortex,  and in increase in the destructive processes involving the nervous structures of the heart, uterus, spinal cord at the end of  pregnancy. A peculiar enzymatic reconstruction with the preservation of the activity of the cholinesterase (CE)-positive pericellular structures (whose number was markedly decreased in comparison with control) was noted against the background of reduction of the CE activity. The prevalence of destructive processes by the end of pregnancy was conditioned by a considerable accumulation of the preparation in the heart, uterus, and the brain (as shown by thin-layer chromatography). The presence of polychlorkamphene in the organs of fetuses pointed to disturbances in the permeability of the transplacental barrier and to a possible influence of the preparation on the development of the fetal nervous system.
D000818:Animals; D001892:Camphanes / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D005260:Female; D005333:Fetus / Q000187:drug effects; D007306:Insecticides / Q000494:pharmacology*; D009420:Nervous System / Q000187:drug effects*; D009474:Neurons / Q000187:drug effects; D011247:Pregnancy; D011270:Pregnancy, Animal / Q000187:drug effects*; D051381:Rats; D013997:Time Factors
D001892:Camphanes; D007306:Insecticides
Vliianie polikhlorkamfena na nekotorye organy i ikh nervnye apparaty u beremennykh zhivotnykh