[Splenocyte autoreactivity of mice of sensitive lines during the latent period of carcinogenesis induced by virus SA7(C8)].
The method of adsorption on a monolayer of embryonal fibroblasts of 51Cr-labelled spleen cells from CBA and C57B1/6 mice infected at birth with SA7(C8) virus was used to show that the cells immune to the antigens of mouse embryo fibroblasts accumulated in the spleen of CBA mice highly susceptible to oncogenesis induced by SA7(C8) virus. In the controls, splenocytes of intact CBA mice were adsorbed on embryonal fibroblast monolayers (the percentage of adsorption 9.8 and 4.2, respectively; P less than 0.05). In the spleen of C57B1/6 mice insusceptible to oncogenesis induced by SA7(C8) virus there was no accumulation of cell antibody to the antigens of embryonal fibroblasts (P greater than 0.1). The detected antibody caused no cytotoxic effect on embryo fibroblasts.
D000818:Animals; D001323:Autoantibodies; D002471:Cell Transformation, Neoplastic / Q000276:immunology*; D003601:Cytotoxicity Tests, Immunologic; D005347:Fibroblasts / Q000276:immunology; D051379:Mice; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D009374:Neoplasms, Experimental / Q000209:etiology; D009858:Oncogenic Viruses; D013154:Spleen / Q000276:immunology*
D001323:Autoantibodies
Autoreaktivnost' splenotsitov mysheĭ chuvstvitel'nykh liniĭ v latentnom periode kantserogeneza, indutsirovannogo virusom SA7(C8)