title: The effects of the angiotensin II antagonist saralasin on blood pressure and plasma aldosterone in man in relation to the prevailing plasma angiotensin II concentration.
abstract: The effect of saralasin in lowering blood pressure and plasma aldosterone concentration in normal subjects, both sodium-replete and sodium-deplete, and in patients with various forms of hypertension, is closely related to the basal plasma angiotensin II concentration. These findings confirm and extend earlier studies of angiotensin II/arterial pressure and angiotensin II/aldosterone dose-response curves. They also emphasize the importance of the renin-angiotensin system in the control of aldosterone in sodium depletion and in renal hypertension.
mesh_terms: D000450:Aldosterone / Q000097:blood*; D000804:Angiotensin II / Q000031:analogs & derivatives* / Q000097:blood*; D001794:Blood Pressure / Q000187:drug effects*; D004032:Diet; D006801:Humans; D006929:Hyperaldosteronism / Q000097:blood / Q000150:complications / Q000503:physiopathology; D006973:Hypertension / Q000097:blood / Q000150:complications / Q000503:physiopathology; D007676:Kidney Failure, Chronic / Q000097:blood / Q000150:complications / Q000503:physiopathology; D008297:Male; D012078:Renal Artery Obstruction / Q000097:blood / Q000150:complications / Q000503:physiopathology; D012083:Renin / Q000097:blood; D012504:Saralasin / Q000494:pharmacology*; D012964:Sodium / Q000502:physiology; D013997:Time Factors
chemical_list: D000804:Angiotensin II; D000450:Aldosterone; D012964:Sodium; D012083:Renin; D012504:Saralasin