Suppression by 1,3-butanediol of the ethanol withdrawal syndrome in rats.
1,3-Butanediol was tested for its ability to suppress an ethanol with drawal syndrome. Male Sprague-Dawley rats were rendered physically dependent on ethanol by intragastric administration of ethanol at a dosage of 9 to 15 grams per kilogram per day over a 4-day period. A nonintoxicating oral dose of 1,3-butanediol at 4 grams per kilogram administered after elimination of ethanol from the blood was effective against the tremulous and conbulsive components of the ethanol withdrawal syndrome in all animals for 1 to 5 hours. This period coincided with the time of maximum severity of the withdrawal syndrome, as seen in the control animals.
D000818:Animals; D002072:Butylene Glycols / Q000627:therapeutic use* / Q000633:toxicity; D004305:Dose-Response Relationship, Drug; D006801:Humans; D008297:Male; D051381:Rats; D013375:Substance Withdrawal Syndrome / Q000188:drug therapy*
D002072:Butylene Glycols