Dicentric X isochromosomes in man.
Four cases of Turner's syndrome are presented in which an apparent X isochromosome i(Xq) has been found to possess two regions of centromeric heterochromatin. It is suggested that these chromosomes were isodicentric structures capable of functioning as monocentric elements as a result of the inactivation of one centromere. The prevalence of mosaicism is believed to be a consequence of the dicentric nature of these chromosomes, and it is considered possible that a high proportion of X isochromosmes are structurally dicentric. Banding patterns showed that the exchange site involved in the formation of the dicentric chromosome was different in at least three of the cases.
D000293:Adolescent; D002648:Child; D005260:Female; D006801:Humans; D009030:Mosaicism; D012730:Sex Chromosomes; D014424:Turner Syndrome / Q000235:genetics*