[Study of the nature of interactions between narcotic analgesics and barbiturates and biological membranes by the method of fluorescent probes].
By employing the method of fluorescent probes the  interaction of the barbituric acid derivatives and phenanthrene with biological membranes was analyzed. An association of phenanthrene derivatives with the probe molecules was uncovered. As a result of hydrophobic interaction the barbituric acid derivatives dislodge the probes from the sites of their bonding with biological membranes. This effect correlates with the distribution coefficient of narcotics in the octanol-water system.
D015057:1-Naphthylamine / Q000031:analogs & derivatives / Q000494:pharmacology; D000654:Amobarbital / Q000494:pharmacology; D000817:Anilino Naphthalenesulfonates / Q000494:pharmacology; D000818:Animals; D001463:Barbiturates / Q000494:pharmacology*; D001665:Binding Sites / Q000187:drug effects; D002462:Cell Membrane / Q000187:drug effects*; D004347:Drug Interactions; D005453:Fluorescence; D008081:Liposomes; D008099:Liver / Q000166:cytology; D008861:Microsomes / Q000187:drug effects*; D009020:Morphine / Q000494:pharmacology*; D010424:Pentobarbital / Q000494:pharmacology; D010634:Phenobarbital / Q000494:pharmacology; D051381:Rats
D000817:Anilino Naphthalenesulfonates; D001463:Barbiturates; D008081:Liposomes; D009020:Morphine; D015057:1-Naphthylamine; D000654:Amobarbital; D010424:Pentobarbital; D010634:Phenobarbital
Izuchenie kharaktera vzaĭmodeĭtsviia narkoticheskikh anal'getikov i barbituratov s biologicheskimi membranami metodom fliuoresttsentnykh zondov.