Abolition of nomifensine-induced stereotypy after 6-hydroxydopamine lesions of ascending dopaminergic projections.
The effects of bilateral focal injections of 6-hydroxydopamine into the zona compacta of the substantia nigra (SNC) on nomifensine-induced stereotypy were examined in the rat. These lesions reduced neostriatal dopamine levels to less than 1 percent of control levels. They also abolished nomifensine-induced stereotyped behavior. It is suggested that nomifensine-induced stereotypy is mediated via a presynaptic action on dopamine uptake and release.
D000818:Animals; D001519:Behavior / Q000187:drug effects*; D004298:Dopamine / Q000502:physiology; D006801:Humans; D006892:Hydroxydopamines / Q000494:pharmacology*; D007546:Isoquinolines / Q000494:pharmacology*; D008297:Male; D051381:Rats; D013239:Stereotyped Behavior / Q000187:drug effects*; D013378:Substantia Nigra / Q000187:drug effects / Q000502:physiology*
D006892:Hydroxydopamines; D007546:Isoquinolines; D004298:Dopamine