[Effect of metaphos on the bile-forming function of the liver].
In experiments with albino male rats the effect of a single introduction into the stomach of methaphos in doses of DL50, 1/10 DL50, 1/20 DL50, 1/50 DL50 and also of a daily consumption of the compound for a month was studied. Metaphos was found to exert a manysided action on the cholopoietic function of the liver, viz. it increases the intensity of the bile secretion, inhibits the synthesis of primary bile acids and conjugation of cholic acid with taurine and glycine, stimulates the formation, conjugation and secretion of bilirubin.
D000818:Animals; D001646:Bile / Q000032:analysis / Q000378:metabolism*; D001647:Bile Acids and Salts / Q000032:analysis / Q000096:biosynthesis; D001663:Bilirubin / Q000378:metabolism; D002784:Cholesterol / Q000378:metabolism; D008099:Liver / Q000187:drug effects* / Q000378:metabolism / Q000502:physiology; D008297:Male; D008743:Methyl Parathion / Q000494:pharmacology*; D010278:Parathion / Q000031:analogs & derivatives*; D051381:Rats; D013268:Stimulation, Chemical
D001647:Bile Acids and Salts; D008743:Methyl Parathion; D010278:Parathion; D002784:Cholesterol; D001663:Bilirubin
Vliianie metafosa na zhelcheobrazovatel'nuiu funktsiu pecheni.