Influence of fibrinogen degradation products (FDP) on the central action of acetylcholine.
Depressive behavioral effects of acetylcholine (10 mug ivtr) and physostigmine (0.3 mg/kg ip), and prolongation of the duration of electrogenic seizures produced by the drugs were prevented by intraperitoneal or intraventricular administration of FDP (0.5 mg/kg or 5 mug resp.). The peptides did not affect the brain acetylcholine level and did not influence the inhibitory effect of physostygmine on AChE activity.
D000109:Acetylcholine / Q000378:metabolism / Q000494:pharmacology*; D000110:Acetylcholinesterase / Q000378:metabolism; D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects; D001921:Brain / Q000187:drug effects* / Q000378:metabolism; D003864:Depression, Chemical; D005338:Fibrin Fibrinogen Degradation Products / Q000494:pharmacology*; D008297:Male; D010830:Physostigmine / Q000494:pharmacology; D051381:Rats; D012640:Seizures / Q000139:chemically induced
D005338:Fibrin Fibrinogen Degradation Products; D010830:Physostigmine; D000110:Acetylcholinesterase; D000109:Acetylcholine