[A cholinergic participation in the increase of cerebral cortical blood flow induced by vincamine (rat) (author's transl)].
The effect of vincamine on cortical blood flow was tested in control rats and after atropine administration. Cortical blood flow was measured in urethanized rats by means of the hydrogen clearance method. A significative increase in cortical blood flow and decrease in blood pressure and cortical vascular resistance was produced by vincamine iv administration in control animals. In atropinized rats significative cortical blood flow changes were not observed although some tendency to increase was detected. It is suggested that increase in cortical blood flow induced by vincamine may be due to direct action on the vascular smooth muscle and, partially, through a cholinergic mechanism.
D000287:Administration, Topical; D000818:Animals; D001783:Blood Flow Velocity; D001794:Blood Pressure / Q000187:drug effects; D002540:Cerebral Cortex / Q000098:blood supply / Q000187:drug effects*; D002560:Cerebrovascular Circulation / Q000187:drug effects*; D007275:Injections, Intravenous; D011048:Polarography / Q000379:methods; D051381:Rats; D013268:Stimulation, Chemical; D014655:Vascular Resistance / Q000187:drug effects; D014748:Vinca Alkaloids / Q000008:administration & dosage / Q000494:pharmacology*
D014748:Vinca Alkaloids
Participación colinérgica en el aumento de flujo cortical cerebral inducido por la vincamina.