Comparative studies on the antitumor effect on intravenous administration of carbazilquinone and mitomycin-C.
Comparison between Carbazilquinone and Mitomycin-C, both of which contain aziridinyl, carbamoyloxy, and quinonyl groups, was made for their therapeutic effect upon intravenous administration. Although both agents exhibited a significant effect on plasmacytoma X5563 in C3H/He mice to a similar extent, Mitomycin-C was not as effective on lympholeukemia L-1210 and on the lung metastasis of Ehrlich carcinoma in (C57BL/6 X DBA/2)F1 (BDF1) mice as was Carbazilquinone. Possible interpretations regarding this discrepancy are discussed.
D000818:Animals; D001389:Azirines / Q000627:therapeutic use*; D002225:Carbazilquinone / Q000008:administration & dosage / Q000627:therapeutic use* / Q000633:toxicity; D002286:Carcinoma, Ehrlich Tumor / Q000188:drug therapy; D005260:Female; D007939:Leukemia L1210 / Q000188:drug therapy; D008175:Lung Neoplasms / Q000188:drug therapy; D051379:Mice; D008815:Mice, Inbred Strains; D008937:Mitomycins / Q000008:administration & dosage / Q000627:therapeutic use* / Q000633:toxicity; D009369:Neoplasms / Q000188:drug therapy*; D010954:Plasmacytoma / Q000188:drug therapy
D001389:Azirines; D008937:Mitomycins; D002225:Carbazilquinone