Noxytiolin and peritoneal adhesion formation.
Clinical and experimental studies have suggested that intraperitoneal noxytiolin prevents adhesion formation. A reliable experimental animal model was therefore established and the effect of noxytiolin on adhesion formation was evaluated in a controlled trial using 80 rats. All 40 rats given Ringer solution developed adhesions, whereas in 7 out of 40 given noxytiolin no adhesions were found (P less than 0-02). Noxytiolin reduced both the total and the mean number of adhesions formed (P less than 0-2) and their mean length of attachment (P less than 0-05). The anti-adhesive effect of noxytiolin may be due to its anticoagulant, cytotoxic or antibacterial properties.
D000818:Animals; D004195:Disease Models, Animal; D005260:Female; D007274:Injections, Intraperitoneal; D009677:Noxythiolin / Q000008:administration & dosage / Q000627:therapeutic use*; D010532:Peritoneal Diseases / Q000209:etiology / Q000517:prevention & control*; D010537:Peritoneum / Q000601:surgery; D051381:Rats; D013890:Thiourea / Q000031:analogs & derivatives*; D000267:Tissue Adhesions
D009677:Noxythiolin; D013890:Thiourea