title: [Plasma kallikrein: new functions].
abstract: The literature data on some new functions of human plasma kallikrein have been discussed. The role of kallikrein as an enzymatic activator of Hageman factor in fluid-phase was emphasized, and the description of this effect, brought about by a feedback mechanism was given. These new findings stress the importance of plasma kallikrein in the initiation of kinin-forming, intrinsing clotting and fibrinolysis. The chemotactic activity of the kallikrein molecule for human neurophiles was considered. New data were given concerning Hageman factor as proteinase and its substrates in human plasma-coagulation factor XI (PTA), plasminogen proectivator and prekallikrein.
mesh_terms: D002634:Chemotaxis, Leukocyte; D010450:Endopeptidases / Q000378:metabolism; D005172:Factor XI / Q000378:metabolism; D005174:Factor XII / Q000502:physiology; D005246:Feedback; D005343:Fibrinolytic Agents / Q000378:metabolism; D006801:Humans; D007610:Kallikreins / Q000502:physiology*; D007705:Kinins / Q000096:biosynthesis; D009504:Neutrophils; D010958:Plasminogen / Q000378:metabolism; D011288:Prekallikrein / Q000378:metabolism
chemical_list: D005343:Fibrinolytic Agents; D007705:Kinins; D005174:Factor XII; D010958:Plasminogen; D005172:Factor XI; D011288:Prekallikrein; D010450:Endopeptidases; D007610:Kallikreins
vernacular_title: Kallikrein plazmy krovi: novye funktsii