Cardiovascular reactivity to noradrenaline and angiotensin in normotensive, hypertensive and 6-hydroxydopamine treated rats.
Blood pressure responses to intravenous noradrenaline and angiotensin in the pithed rat preparations from normotensive, chronically hypertensive and 6-hydroxydopamine (6-OHDA) treated groups were found to follow different patterns. 6-OHDA treated rats were very sensitive to the effects of the two pressor agents and repeated administration of the two drugs invariably led to cardiovascular collapse.
D000804:Angiotensin II / Q000494:pharmacology*; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D005260:Female; D006439:Hemodynamics / Q000187:drug effects*; D006892:Hydroxydopamines / Q000008:administration & dosage*; D006977:Hypertension, Renal / Q000188:drug therapy / Q000503:physiopathology*; D008297:Male; D009638:Norepinephrine / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains
D006892:Hydroxydopamines; D000804:Angiotensin II; D009638:Norepinephrine