Mouse foetal development: translational inactivation of globin genes during the terminal differentiation of yolk sac erythroid cells.
The molecular mechanism of globin genes inactivation has been explored at the translational level in yolk sac erythroid cells from mouse foetuses. Ageing of the messenger molecules is paralleled by a progressive decrease of the poly(A) tail. Poly(A) less messengers are less active when tested in a wheat germ cell free system and become uncapable to terminate globin chain elongation.
D000367:Age Factors; D000818:Animals; D004920:Erythropoiesis; D005260:Female; D006454:Hemoglobins / Q000096:biosynthesis*; D051379:Mice; D008810:Mice, Inbred C57BL; D011061:Poly A / Q000378:metabolism; D011132:Polyribosomes / Q000378:metabolism*; D014176:Protein Biosynthesis; D012333:RNA, Messenger / Q000378:metabolism*; D014817:Vitelline Membrane / Q000166:cytology / Q000378:metabolism*
D006454:Hemoglobins; D012333:RNA, Messenger; D011061:Poly A