[Trans-membrane difference of the vascular wall potentials and electrolyte content under the effect of nicotine and pentamine].
In experiments with anesthetized cats the effect of nicotine and pentamine with their intravenous administration into the organism on the transmembraneous difference on the carotid artery potentials and electrolytes exchange in the vascular wall was analyzed. Nicotine (60 and 120 gamma/kg) was found to increase the difference of potentials in the vascular wall of the carotid artery and pentamine (1 and 10 mg/kg)--to reduce it. Nicotine raised the level of potassium and downgraded the sodium concentration in the vascular wall, while changes in the proportion of calcium and magnesium ions proved to be insignificant and were demonstrable only in individual vessels. Pentamine increased the potassium and sodium content in the wall of blood vessels, excercising but little effect on the level of calcium and magnesium ions. A relation between changes in the transmembraneous difference of potentials and variations of the ionic composition in the vascular wall, mostly of potassium and sodium ions, is suggested.
D000818:Animals; D001011:Aorta / Q000378:metabolism; D008725:Bis-Trimethylammonium Compounds / Q000494:pharmacology*; D001794:Blood Pressure / Q000187:drug effects; D001808:Blood Vessels / Q000187:drug effects* / Q000378:metabolism*; D002339:Carotid Arteries / Q000166:cytology / Q000378:metabolism; D002415:Cats; D002462:Cell Membrane / Q000502:physiology; D002463:Cell Membrane Permeability / Q000187:drug effects; D005260:Female; D005263:Femoral Artery / Q000378:metabolism; D008297:Male; D008564:Membrane Potentials / Q000187:drug effects*; D009538:Nicotine / Q000494:pharmacology*; D011188:Potassium / Q000378:metabolism; D012964:Sodium / Q000378:metabolism*; D014684:Venae Cavae / Q000378:metabolism
D008725:Bis-Trimethylammonium Compounds; D009538:Nicotine; D012964:Sodium; D011188:Potassium
Transmembrannaia raznost' potentsialov sosudistoĭ stenki i soderzhanie v neĭ elektrolitov pri deĭstvii nikotina i pentamina.