[Lysosomal enzymatic activity in a hepatotoxic lesion in white rats].
Beta-N-acetylglucoss aminidase and beta-galactosidase serum activity, as well as total and free activity of the former in liver homogenate are studied in the listed below groups of rats experimented upon: group I--controls, group II--fed perorally with 200 000 IU/kg body weight vitamin A for seven days, group III--injected i.p. with 150 mg/kg body weight thioacetamide, 24 hours prior to sacrification, and group IV--thioacetamide was given within seven days of vitamin A treatment. The recorded serum and free activity rise of the enzymes under study is due to the increased permeability of the lysosome and cellular membrane in the group with high vitamin A doses; the increase of the permeability is more pronounced in the group treated with thioacetamide, and in the group subjected to the combined effect of the two factors.
D000818:Animals; D002463:Cell Membrane Permeability / Q000187:drug effects; D004338:Drug Combinations; D004789:Enzyme Activation / Q000187:drug effects; D008099:Liver / Q000187:drug effects* / Q000201:enzymology; D008247:Lysosomes / Q000187:drug effects / Q000201:enzymology*; D008297:Male; D051381:Rats; D013853:Thioacetamide / Q000633:toxicity; D014801:Vitamin A / Q000633:toxicity
D004338:Drug Combinations; D013853:Thioacetamide; D014801:Vitamin A
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