Hemodynamic and metabolic changes caused by regional ischemia in porcine heart.
Myocardial ischemia was induced in the pig by reducing the left anterior descending coronary artery (LAD) flow to 26% of its control value. After one hour, the LAD was reperfused for 50 minutes. During ischemia and reperfusion, cardiac output correlated strongly with arterial levels of lactate and nucleosides (all r less than - 0.85). Myocardial inosine production seems to be a good marker of ischemia because it correlated very well with myocardial lactate production (r = 0.99).
D000818:Animals; D002302:Cardiac Output; D003327:Coronary Disease / Q000503:physiopathology*; D006321:Heart / Q000503:physiopathology*; D006352:Heart Ventricles / Q000503:physiopathology; D006439:Hemodynamics; D007042:Hypoxanthines / Q000378:metabolism; D007288:Inosine / Q000378:metabolism; D007773:Lactates / Q000378:metabolism; D009206:Myocardium / Q000378:metabolism*; D010101:Oxygen Consumption; D010477:Perfusion; D012039:Regional Blood Flow; D013552:Swine
D007042:Hypoxanthines; D007773:Lactates; D007288:Inosine