[Determination of antithyroglobulin antibodies: comparison of three immunologic methods (author's transl)].
Antithyroglobulin antibodies were investigated in various thyroidopathy using 3 immunological technics. The radio-immunological methods are a little more sensitive and more reproducible that passive hemagglutination. In the radio-immunological methods the polyethylene glycol precipitation is less expensive but less sensitive and less reproductible than the double precipitation procedure. This one imply to perform a dilution curve of positive serum because of the modifications of the slope during the dilution. This technic allows a detection with high frequency of antithyroglobulin antibodies particularly in Hashimoto thyroiditis and chronic thyroiditis. One can observe the higher incidence in primary hypothyroidism and in Graves' disease which seems to imply auto-immun factors in these diseases.
D000818:Animals; D000906:Antibodies / Q000032:analysis*; D004306:Dose-Response Relationship, Immunologic; D005069:Evaluation Studies as Topic; D006386:Hemagglutination Tests / Q000379:methods; D006801:Humans; D007122:Immunoelectrophoresis / Q000379:methods; D008722:Methods; D011092:Polyethylene Glycols; D011817:Rabbits / Q000276:immunology; D013954:Thyroglobulin / Q000276:immunology*; D013959:Thyroid Diseases / Q000276:immunology
D000906:Antibodies; D011092:Polyethylene Glycols; D013954:Thyroglobulin
Le dosage des anticorps antithyroglobulines. Comparaison entre trois méthodes immunologiques