[Oxidative phosphorylation in the mitochondria of various parts of the myocardium in patients with combined mitral valve defects].
The oxidative phosphorylation in the mitochondria of the left auriculum and the papillary muscles of the left ventricle was studied in 73 patients with combined mitral valve defects subjected to mitral valve prosthetic replacement. The examination was conducted polarographically by Chance's technique, the oxidation substrate being 10 mm alpha-ketoglutarate. The rate of oxidation in various metabolic states and the rate of phosphorylation were demonstrated to decrease along with the increasing course of the disease, the activeness of the rheumatic process, and the predominance of stenosis. In cases of distinct calcification of mitral valve the respiration rate increases in the 4th state, while the respiratory control--decreases. Nitrous oxide anaesthesia, in contrast to ether, results in a decreasing efficacy and rate of phosphorylation. The possible mechanisms of these changes are discussed.
D000328:Adult; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D008931:Mitochondria, Muscle / Q000378:metabolism*; D008944:Mitral Valve Insufficiency / Q000150:complications / Q000378:metabolism*; D008946:Mitral Valve Stenosis / Q000150:complications / Q000378:metabolism*; D009206:Myocardium / Q000473:pathology*; D010085:Oxidative Phosphorylation
Okislitel'noe fosforilirovanie v mitokhondriiakh razlichnykh otdelov miokarda u bol'nykh kombinirovannymi mitral'nymi porokami serdtsa