[The effect of n-butanol on the metabolic status of some organs of rats and the circulation of rabbits].
Rats received n-butanol i.m. in a dose of 0.1 g/kg body weight/die during 50 days. The metabolic status of some organs was examined and compared to that of rats which in control experiments had received 0.9% NaCl-colution in an equivalent volume (double blind experiments). The tissue levels of metabolites of the adenylic acid-creatine phosphate system, of glycogen, glucose and lactate exhibited no significant differences in both the groups. In the liver the tissue level of glycogen, free creatine and total creatine was significantly elevated in rats which had received n-butanol. In concious rabbits the effect of n-butanol on circulatory parameters was investigated in double blind experiments. n-butanol was without a significant effect in a dosage of 0.008 g/kg. A dosage of 0.033 g/kg and particularly of 0.1 g/kg resulted in a transitory decrease in the heart rate and the systolic and especially diastolic blood pressure.
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D000440:Butanols / Q000494:pharmacology*; D004734:Energy Metabolism / Q000187:drug effects*; D005260:Female; D006339:Heart Rate / Q000187:drug effects; D006439:Hemodynamics / Q000187:drug effects*; D007668:Kidney / Q000378:metabolism; D008099:Liver / Q000378:metabolism; D008297:Male; D009132:Muscles / Q000378:metabolism; D009206:Myocardium / Q000378:metabolism; D011817:Rabbits; D051381:Rats
D000440:Butanols
Die Wirkung von n-Butanol auf den Stoffwechselstatus einiger Organe der Ratte und den Kreislauf von Kaninchen