Studies on platelet function in cases of hemophiliac Egyptian children.
Eleven cases of hemophilia were studied for detection of any change in the platelet function. The results showed hyperfunction in 5 cases, normal function in 4, and hypofunction in the remaining two. The hyperfunction of the platelets was shown in the case with acute hemorrhage and it might be a compensation mechanism. The normal function was shown in cases during the quiescent phase. The hypofunction of the platelets was associated with the presence of AHg inhibitor and platelet antibody. Normal function returned after Cortisone administration. It may be postulated that the inhibitor of factor VIII and the platelet antibody are one and the same thing.
D000293:Adolescent; D000906:Antibodies; D001780:Blood Coagulation Tests; D001792:Blood Platelets / Q000276:immunology / Q000502:physiology*; D002648:Child; D002675:Child, Preschool; D003298:Coombs Test; D006467:Hemophilia A / Q000097:blood*; D006801:Humans; D008297:Male; D010973:Platelet Adhesiveness; D010974:Platelet Aggregation
D000906:Antibodies