[Effect of corazole on the functional activity of the caudate nucleus].
In chronic experiments with freely moving cats the action of diverse metrazol doses on the d,1-amphetamine-induced stereotype behaviour and the arrest reaction following low frequency stimulation of the caudate nucleus was studied. After injections of metrazol (20--30 mg/kg, i.c.) myoclonic seizure jerks and decreased locomotion occurred. This state was accompanied by depression of the stereotype behaviour and lowered arrest reaction threshold. It is suggested that some behavioural and the EEG metrazol-induced changes may come as a result of the caudate nucleus activation.
D000661:Amphetamine / Q000494:pharmacology; D000818:Animals; D001519:Behavior / Q000187:drug effects*; D002415:Cats; D002421:Caudate Nucleus / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D004347:Drug Interactions; D006801:Humans; D009043:Motor Activity / Q000187:drug effects; D010433:Pentylenetetrazole / Q000494:pharmacology*; D013239:Stereotyped Behavior / Q000187:drug effects*
D000661:Amphetamine; D010433:Pentylenetetrazole
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