Effect of intravasal copper on the fertility of rats.
Copper wire was inserted into the vas deferens and its effect of the reproductive system and fertility performance of rats was investigated. The copper wire was 100% effective as a contraceptive for up to 4 months if placed correctly, and resulted in decapitation of most of the spermatozoa. No differences between the rats with an intravasal copper wire and the sham-operated controls were found for the weights of the gonads and accessory sex glands or for protein, RNA, DNA and fructose concentrations. The intravasal copper device appears to be promising for the development of a long-term method for male contraception.
D000818:Animals; D003272:Contraceptive Agents, Male; D003300:Copper / Q000008:administration & dosage / Q000494:pharmacology*; D004247:DNA / Q000032:analysis; D005298:Fertility / Q000187:drug effects*; D005632:Fructose / Q000032:analysis; D008297:Male; D009929:Organ Size; D011506:Proteins / Q000032:analysis; D012313:RNA / Q000032:analysis; D051381:Rats; D013094:Spermatozoa / Q000187:drug effects; D013737:Testis / Q000032:analysis; D014649:Vas Deferens / Q000601:surgery
D003272:Contraceptive Agents, Male; D011506:Proteins; D005632:Fructose; D012313:RNA; D003300:Copper; D004247:DNA