The effect of prostaglandin E2 on thyroidal secretion of hormonal iodine in the pig.
The thyroid gland isolated in situ in 4 pigs was perfused with PGI2 given at increasing rates (1.38, 2.75, 13.8, 27.5 and 138 ng/mn). In the all animals a significant dose-dependent reduction in hormonal iodine secretion rate was observed. These results confirm in vitro experiments with PGE1 (Burke et al., 1972).
D000818:Animals; D066298:In Vitro Techniques; D007455:Iodine / Q000378:metabolism*; D011458:Prostaglandins E / Q000494:pharmacology*; D013552:Swine / Q000502:physiology*; D013961:Thyroid Gland / Q000187:drug effects* / Q000378:metabolism
D011458:Prostaglandins E; D007455:Iodine