Some metabolic and hormonal effects of salbutamol in man.
The effect of i.v. infusion of a beta-adrenergic stimulant, salbutamol on blood insulin, glucose, lactate, phosphates, potassium and NEFA was studied in 9 normal subjects. The effect of the drug on the blood sugar and insulin response to i.v. glucose was also examined in 4 subjects. Salbutamol was followed by increases in insulin, glucose and lactate, and a fall in blood phosphorus and potassium. NEFA values did not change significantly. These effects of salbutamol were abolished by propranolol and may thus be attributed to its beta-adrenergic stimulating action. Salbutamol also induced a reduction in glucose tolerance, in spite of the presence of enhanced blood insulin levels.
D000328:Adult; D000420:Albuterol / Q000494:pharmacology*; D001786:Blood Glucose / Q000378:metabolism; D005230:Fatty Acids, Nonesterified / Q000097:blood; D005260:Female; D006801:Humans; D007328:Insulin / Q000097:blood; D007545:Isoproterenol / Q000494:pharmacology; D007773:Lactates / Q000097:blood; D008297:Male; D010710:Phosphates / Q000097:blood; D011188:Potassium / Q000097:blood; D011433:Propranolol / Q000494:pharmacology
D001786:Blood Glucose; D005230:Fatty Acids, Nonesterified; D007328:Insulin; D007773:Lactates; D010710:Phosphates; D011433:Propranolol; D007545:Isoproterenol; D000420:Albuterol; D011188:Potassium