title: The synthesis of ethyl apovincaminate.
abstract: Starting from (+) vincamine (I), simple derivatives of vincaminic acid (II), apovincaminic acid (V) and apovincaminol (VII) were synthetized. Out of these the synthesis of ethyl apovincaminate (Cavinton), as a representative, is described in detail. The water elimination and esterification of II can be carried out in one step.
mesh_terms: D014665:Vasodilator Agents; D014748:Vinca Alkaloids / Q000138:chemical synthesis*
chemical_list: D014665:Vasodilator Agents; D014748:Vinca Alkaloids