The etiology of transmissible murine colonic hyperplasia.
The etiology of a transmissable colonic mucosal hyperplasia of mice was investigated. Hyperplasia was produced in mice inoculated with unfiltered colonic suspension from affected mice, but infectivity was lost after passage through a 0.45 mum filter. The etiologic agent was subsequently identified as a variant of Citrobacter freundii. The organism induced colonic mucosal hyperplasia when inoculated into germfree mice, and it was recovered in pure culture from the affected animals.
D000818:Animals; D002954:Citrobacter; D003106:Colon / Q000473:pathology; D003108:Colonic Diseases / Q000209:etiology / Q000473:pathology / Q000662:veterinary*; D004756:Enterobacteriaceae Infections / Q000209:etiology / Q000473:pathology / Q000662:veterinary*; D006965:Hyperplasia; D051379:Mice; D012376:Rodent Diseases / Q000209:etiology* / Q000473:pathology