[Effect of lithium chloride on kidney function in rats].
Test staged on rats have brought evidence that lithium chloride acts damagingly on all parts of the nephron, inhibiting, first of all, the processes of filtration and then of secretion and reabsorption. Polyuria arising under the effect of lithium is caused by reduced reabsorption of water in the tubules and anuria--by depression of the glomerular filtration.
D000818:Animals; D001002:Anuria / Q000139:chemically induced; D003404:Creatinine / Q000097:blood; D004231:Diuresis / Q000187:drug effects; D005260:Female; D005919:Glomerular Filtration Rate; D006029:Glycosuria / Q000139:chemically induced; D007668:Kidney / Q000187:drug effects* / Q000502:physiology; D007684:Kidney Tubules / Q000378:metabolism; D008094:Lithium / Q000009:adverse effects / Q000494:pharmacology*; D008297:Male; D011141:Polyuria / Q000139:chemically induced; D011507:Proteinuria / Q000139:chemically induced; D051381:Rats; D014508:Urea / Q000378:metabolism
D014508:Urea; D008094:Lithium; D003404:Creatinine
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