Chronic intermittent ethyl alcohol inhalation and avoidance learning.
Weanling male and female rats were chronically exposed to alcohol for 50 days using an intermittent inhalation technique which does not cause alcohol dependency. After 17 days of no exposure to alcohol, animals began two-way active avoidance testing. Results indicated that males were impaired on this task and females were not while at the same time males had reduced body weights. The male weight reduction was not responsible for the avoidance impairment. It was concluded that impaired avoidance learning following chronic esposure to alcohol is not specific to dependency models of animal alcoholism.
D000336:Aerosols; D000437:Alcoholism; D000818:Animals; D001362:Avoidance Learning / Q000187:drug effects*; D001835:Body Weight / Q000187:drug effects; D004597:Electroshock; D000431:Ethanol / Q000008:administration & dosage / Q000097:blood / Q000494:pharmacology*; D005260:Female; D006801:Humans; D008297:Male; D051381:Rats; D012737:Sex Factors; D013997:Time Factors
D000336:Aerosols; D000431:Ethanol