Sex and genetic differences in the elimination of sulphadimidine in rats.
Rats of five inbred strains and two random-bred stocks were intravenously given sulphadimidine (40 mg/kg body weight). A relatively low percentage of acetylsulphadimidine (Ac-S) in urine and absence of strain differences were found in males, whereas two phenotypes can be distinguished in females: (1) high percentage of Ac-S in urine, and (2) low percentage of Ac-S in uirne. An autosomal control of these differences is suggested. A dominant allele which determines the high percentage of excreted Ac-S manifests itself only in female endo-environment.
D000107:Acetylation; D000818:Animals; D003434:Crossing Over, Genetic; D005260:Female; D007275:Injections, Intravenous; D008297:Male; D010641:Phenotype; D051381:Rats; D011919:Rats, Inbred Strains / Q000378:metabolism*; D012737:Sex Factors; D013045:Species Specificity; D013418:Sulfamethazine / Q000008:administration & dosage / Q000378:metabolism*
D013418:Sulfamethazine