[Comparative investigations of psychoses in parents, children and siblings (author's transl)].
Psychoses in 441 hospital patients from 210 families have been investigated comparatively. In 106 families 109 parents and 117 children suffer as do 215 siblings in 104 families. It has been established that the sexual appurtenance does not have a decisive importance in the genetic transmission of the psychoses, while comparing the diagnoses, a high percentage (84.5%) of coincidence is founded. Similarities appear in the clinical features, in their course, and the therapeutical effect. The psychoses begin at an earlier age and are taking a heavier course in children, when compared to parents and in the younger brothers and sisters when compared to the elder. In couples with different diagnoses, a similarity is determined as far as the investigated indices are concerned. The clinical features are atypical and symptoms and syndromes, characteristic for the different families, are manifested.
D000275:Adjustment Disorders / Q000235:genetics; D000342:Affective Symptoms / Q000235:genetics; D000367:Age Factors; D001714:Bipolar Disorder / Q000235:genetics; D003865:Major Depressive Disorder / Q000235:genetics; D005260:Female; D006801:Humans; D008297:Male; D011618:Psychotic Disorders / Q000235:genetics*; D012559:Schizophrenia / Q000235:genetics; D012737:Sex Factors
Vergeichende Untersuchungen an Psychosen von Eltern, Kindern und Geschwistern