Effect of some lipids on the activity of renin in vitro.
A partially purified bovine renin preparation and a homologous renin substrate were used to study the effect of some lipids on the amount of angiotensin formed. It was found that lecithin and the detergents used (deoxycholate and sodium dodecylate) inhibited the renin activity. Palmitic acid, oleic acid and cholesterol had no distinct effect. On the other hand, the reaction was enhanced by prostaglandins E2 and F2alpha.
D000804:Angiotensin II / Q000096:biosynthesis; D000818:Animals; D002417:Cattle; D003840:Deoxycholic Acid / Q000494:pharmacology; D008055:Lipids / Q000494:pharmacology*; D010713:Phosphatidylcholines / Q000494:pharmacology; D011458:Prostaglandins E / Q000494:pharmacology; D011460:Prostaglandins F / Q000494:pharmacology; D012083:Renin / Q000378:metabolism*; D013268:Stimulation, Chemical; D000092502:Renin Inhibitors
D000804:Angiotensin II; D003840:Deoxycholic Acid; D008055:Lipids; D010713:Phosphatidylcholines; D011458:Prostaglandins E; D011460:Prostaglandins F; D012083:Renin; D000092502:Renin Inhibitors