[Formation of tetraploid nuclei in regenerating rat liver].
The proliferation of binucleated cells in the liver of young Wistar rats after partial (2/3) hepatectomy was studied by means of autoradiography and cytophotometry. The analysis of the kinetics of 3H-thymidine labelled cells has shown that both the bi- and mononucleated cells proceed through the mitotic cycle and enter mitosis simultaneously. The nuclei of 2nX2 cells enter prophase simultaneously but fuse during metaphase, so that the subsequent division results in the formation of mononucleated tetraploid cells.
D000818:Animals; D001345:Autoradiography; D002467:Cell Nucleus; D002875:Chromosomes; D007553:Isotope Labeling; D008099:Liver / Q000166:cytology*; D008115:Liver Regeneration; D008297:Male; D008938:Mitosis; D010783:Photometry / Q000379:methods; D011123:Polyploidy; D051381:Rats; D013936:Thymidine; D014316:Tritium
D014316:Tritium; D013936:Thymidine
Obrazovanie tetraploidnykh iader v regeneriruiushcheĭ pecheni krys