Bioavailability assessment under quasi- and nonsteady-state conditions III: Application.
The applicability of bioavailability assessment at quasi- and nonsteady state is illustrated with data from a study comparing two formulations of amitriptyline hydrochloride in humans. Relative bioavailability as a function of the observed mean plasma concentrations may be expressed in closed form, provided the affected intervals begin and end in the log-linear region. Alternatively, numerical, graphical and/or electronic computational techniques may be used to stimulate the appropriate [Cp(i)]sim, the proximity of which to [Cp(i)]obs is a function of relative bioavailability and omega. If a model can be found to fit the data adequately, it would be sufficient that only one sampled interval end in the log-linear phase.
D000639:Amitriptyline / Q000008:administration & dosage / Q000097:blood / Q000378:metabolism*; D001682:Biological Availability; D001702:Biopharmaceutics; D002214:Capsules; D006801:Humans; D007700:Kinetics; D008433:Mathematics; D008722:Methods; D008954:Models, Biological; D013607:Tablets
D002214:Capsules; D013607:Tablets; D000639:Amitriptyline