Reactions to intravenous injections of diazepam.
Local reactions during and after i.v. injection of two different formulations of diazepam were studied. Two-thirds of the patients felt pain during the injection. Verfied or probable thrombophlebitis occurred with increasing frequency following operation, indicating a late onset. One month after discharge, 29% of those who had received diazepam in glycoferol-alcohol-benzoic acid complained of tender injection sites, compared with only 10% of the patients who received diazepam in cremophor EL. The difference is significant, indicating an influence of the solvent system.
D003975:Diazepam / Q000008:administration & dosage / Q000009:adverse effects*; D006801:Humans; D007275:Injections, Intravenous; D010146:Pain / Q000139:chemically induced; D012997:Solvents / Q000009:adverse effects; D013924:Thrombophlebitis / Q000139:chemically induced; D013997:Time Factors
D012997:Solvents; D003975:Diazepam