The role of heterogeneity of tumour cell populations in biological activity and sensitivity to chemotherapeutics.
The biological activity of a rat ascites leukaemia subline isolated by isopycnic centrifugation was compared to that of the original tumour both in vivo and in vitro. The subline had different marker chromosomes, a longer cell cycle time and decreased sensitivity to vinblastine as compared to the original tumour.
D000818:Animals; D002453:Cell Cycle; D002469:Cell Separation; D002478:Cells, Cultured; D066298:In Vitro Techniques; D007621:Karyotyping; D007942:Leukemia, Experimental / Q000188:drug therapy / Q000235:genetics*; D008938:Mitosis / Q000187:drug effects; D009368:Neoplasm Transplantation; D051381:Rats; D014747:Vinblastine / Q000494:pharmacology* / Q000627:therapeutic use
D014747:Vinblastine