Use of cell-cycle information in the preparation of drug combinations: results with cytosine arabinoside plus actinomycin D1,2.
Cytosine arabinoside (ara-C) plus actinomycin D acted synergistically in killing L1210 and DON cells. The time course of cell-kill by the combination was different from that seen for either drug alone. The results obtained (both with L1210 and synchronous DON cells) suggest that cells blocked in G1/S with continuing unbalanced growth are particularly sensitive to the combined action of ara-C and actinomycin D.
D000818:Animals; D002455:Cell Division / Q000187:drug effects; D002470:Cell Survival / Q000187:drug effects; D002478:Cells, Cultured; D003561:Cytarabine / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D004273:DNA, Neoplasm / Q000096:biosynthesis; D003609:Dactinomycin / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D004357:Drug Synergism; D004359:Drug Therapy, Combination; D007939:Leukemia L1210 / Q000188:drug therapy / Q000378:metabolism / Q000473:pathology; D012334:RNA, Neoplasm / Q000096:biosynthesis
D004273:DNA, Neoplasm; D012334:RNA, Neoplasm; D003561:Cytarabine; D003609:Dactinomycin