Release of highly soluble substances from inert matrices in cases of two-sided attack of the solvent.
The present work is an extension of some of our earlier investigations on the release of soluble substances in inert matrices. There have been described the cases of two-sided attack on the inert matrices (PVC and PE) by the solvent. The theoretical considerations of the cases for the two-sided attack were experimentally confirmed. The values of the diffusion coefficients, which correspond to the calculated ones in the cases of one-sided attack, were calculated as well.
D004058:Diffusion; D008962:Models, Theoretical; D014677:Pharmaceutical Vehicles; D012995:Solubility; D013607:Tablets
D014677:Pharmaceutical Vehicles; D013607:Tablets