Effect of ethyl apovincaminate on cerebral, cardiac and renal flow rate in dogs in the course of administration.
Cerebral, myocardial and renal capillary flow rate was significantly increased by 10 to 20 mug/kg/min doses of ethyl apovincaminate (RGH-4405, Cavinton) injected in slow infusion to dogs. These effects were long-lasting. Since perfusion pressure and heart rate were not affected by the compound, it was concluded that increased flow rate was attributable to decrease of peripheral vascular resistance. Results indicate that Cavinton has a vasodilatory effect.
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D002560:Cerebrovascular Circulation / Q000187:drug effects*; D003326:Coronary Circulation / Q000187:drug effects*; D004285:Dogs; D006339:Heart Rate / Q000187:drug effects; D007263:Infusions, Parenteral; D007275:Injections, Intravenous; D007672:Kidney Cortex / Q000098:blood supply*; D012039:Regional Blood Flow / Q000187:drug effects; D014655:Vascular Resistance / Q000187:drug effects; D014748:Vinca Alkaloids / Q000494:pharmacology*
D014748:Vinca Alkaloids