[Enzymatic mechanisms of inhibition of peroxidative oxidation in different regions of rat brain].
Activities of catalase, superoxide dismutase, glutathione peroxidase were studied in the cortex, cerebellul and stem of rat brain. The presence of glutathione: dehydroascorbate reductase was observed in rat brain. The highest levels of catalase, superoxide dismutase and the lowest levels of glutathione peroxidase, glutathione: dehydroascorbate reductase were found in the stem; the level of glutathione peroxidase was highest in the cerebellum. The significant part (30--40%) of thiol containing substances was bound with proteins as mixed disulfides. The role of the enzymes studied in regulation of free-radical processes and of the content of peroxides in brain tissue is discussed.
D000818:Animals; D001921:Brain / Q000201:enzymology*; D001933:Brain Stem / Q000201:enzymology; D002374:Catalase / Q000378:metabolism; D002531:Cerebellum / Q000201:enzymology; D002540:Cerebral Cortex / Q000201:enzymology; D003683:Dehydroascorbic Acid; D005979:Glutathione Peroxidase / Q000378:metabolism; D008297:Male; D010084:Oxidation-Reduction; D010088:Oxidoreductases / Q000378:metabolism; D051381:Rats; D013482:Superoxide Dismutase / Q000378:metabolism
D010088:Oxidoreductases; D002374:Catalase; D005979:Glutathione Peroxidase; D013482:Superoxide Dismutase; C020666:glutathione dehydrogenase (ascorbate); D003683:Dehydroascorbic Acid
Fermentativnye mekhanismy tormezheniia perekisnogo okisleniia v razlichnykh otdelakh golovnogo mozga