Random repression, immunological surveillance and hyperthermia.
A theoretical model of random repression of genetic information in a cancer cell is related to the efficiency of the immune system in removing cancer cells. It is suggested that at some elevated temperature, binding of a certain repressor molecule to the genome ceases and that the cell loses its random properties. We conclude with the idea that elevated temperature increases the efficiency of the immune system.
D000328:Adult; D000951:Antigens, Neoplasm; D002648:Child; D006358:Hot Temperature; D006801:Humans; D006979:Hyperthermia, Induced; D007109:Immunity; D008297:Male; D008954:Models, Biological; D009369:Neoplasms / Q000235:genetics / Q000276:immunology* / Q000628:therapy; D009876:Operon
D000951:Antigens, Neoplasm