[Reactivity of isolated arteries from hypertensive rabbits].
Isolated vessels (aorta thoracica, a pulmonalis, a. femoralis, a. renalis) of neurogenous-interoceptive and nephrogenous hypertensive rabbits showed a changed sensitivity to several vasoactive agents. An increased reactivity to noradrenaline, histamine, and serotonin in the aorta of neurogenous hypertensive rabbits, in the a. pulmonalis of neurogenous and renal hypertensive rabbits and in the a. femoralis of renal hypertensive animals in comparison with controls could be shown. Also registered was a hyperactivity to BaCl2 and KCl. All vessels of hypertensive rabbits were hyporeactive to angiotensin. They increased vascular reactivity was seen already in the 3rd week after removal of one kideny and pressoric receptors respectively. It is supposed that a "true supersensitivity" of the vascular smooth muscle cells of the hypertensive arteries does exist.
D000804:Angiotensin II / Q000494:pharmacology; D000818:Animals; D001013:Aorta, Thoracic / Q000187:drug effects; D001158:Arteries / Q000187:drug effects* / Q000503:physiopathology; D005260:Female; D005263:Femoral Artery / Q000187:drug effects; D006632:Histamine / Q000494:pharmacology; D006973:Hypertension / Q000503:physiopathology*; D008297:Male; D009638:Norepinephrine / Q000494:pharmacology; D011651:Pulmonary Artery / Q000187:drug effects; D011817:Rabbits; D012077:Renal Artery / Q000187:drug effects; D012701:Serotonin / Q000494:pharmacology
D000804:Angiotensin II; D012701:Serotonin; D006632:Histamine; D009638:Norepinephrine
Zur Reagibilität isolierter Arterien hypertoner Kaninchen