title: [Clinical manifestations of the local effect of protons with an energy of 1000 Mev following irradiation of the hypophysis (experimental)].
abstract: In order to study the clinical picture due to inrradiation of the hypophysis by protons with an energy of 1000 Mev with the use of a pendulum technique, the authors examined 30 dogs including 27 with an irradiated hypophysis and 3 control animals during 2 years. The results were verified in autopsies and in histological studies. These examinations demonstrated frequent general cerebral symptoms, focal neurological and hypophysis-endocrinological symptoms as well as frequent lesions of the cranial nerves, epileptic seizures and nonsymptomatic focal brain necrosis. It was also possible to demonstrate a correlation of the clinical traits with the dosage of the irradiation and the time past after irradiation. The report contains corrections for using these data on humans.
mesh_terms: D000818:Animals; D001921:Brain / Q000473:pathology*; D004285:Dogs; D010910:Pituitary Irradiation / Q000009:adverse effects*; D011522:Protons; D011833:Radiation Injuries, Experimental / Q000175:diagnosis* / Q000473:pathology; D013577:Syndrome
chemical_list: D011522:Protons
vernacular_title: Klinicheskie proiavleniia mestnogo deĭstviia protonov s énergieĭ 1000 MeV pri obluchenii gipofiza (v éksperimente)