Phytohemagglutinin unresponsiveness of spleen cells of mice bearing an allogeneic lymphoma.
The in vitro response of spleen cells to phytohemagglutinin (PHA) was studied in BALB mice bearing an allogeneic AKR lymphoma (progressors). A significant decrease in blast transformation and DNA synthesis was observed in these animals as compared with those rejecting the tumor (regressors) or with unchallenged controls. It is postulated that either an alteration in PHA lymphocyte receptors or the presence of enhancing serum factors may be responsible for this decrease in PHA response.
D000818:Animals; D000917:Antibody Formation; D004273:DNA, Neoplasm / Q000096:biosynthesis; D005260:Female; D037102:Lectins; D008213:Lymphocyte Activation; D008223:Lymphoma / Q000276:immunology* / Q000378:metabolism; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D009374:Neoplasms, Experimental / Q000276:immunology / Q000378:metabolism; D013154:Spleen / Q000276:immunology*
D004273:DNA, Neoplasm; D037102:Lectins