[Changes in the serum activity of lysosomal enzymes in rats after the use of propoxur (Baygon) insecticide. 2. The dynamics of beta-N-acetylglucosaminidase].
The influence of 1/50 and 1/10 LD50 of the monomethylcarbamate insecticide Propoxur (Baygon) on the lysosome enzyme beta-N-acetylglucose-aminidase serum activity is studied in white rats upon daily administration per os, over a period of 2, 4, 8, 15, 30, 60 and 90 days. A statistically significant increase of the enzyme activity is recorded at 15 days after introduction of 1/50 LD50, and at 15 and 30 days after 1/10 LD50 administration, followed by a reduction of the activity and returning to normal values. In all likelihood, the harmful effect of Propoxur on the lysosome and cellular membrane decreases after the 15th day because of activation of the microsome enzymes which, in turn, speed up the process of rendering innocuous the insecticide administered.
D000118:Acetylglucosaminidase / Q000097:blood*; D000818:Animals; D004305:Dose-Response Relationship, Drug; D004789:Enzyme Activation / Q000187:drug effects; D006596:Hexosaminidases / Q000097:blood*; D008247:Lysosomes / Q000187:drug effects* / Q000201:enzymology; D008297:Male; D001074:Propoxur / Q000633:toxicity*; D051381:Rats; D013997:Time Factors
D001074:Propoxur; D006596:Hexosaminidases; D000118:Acetylglucosaminidase
Promeni v serumnata aktivnost na niakoi lizozomni enzimi u plukhove sled prilaganeto na insektitsida propoksur (baĭgona). 2. Dinamika na beta-N-atsetilgliukozaminidazata.