[Comparative characteristics of compensatory renal hypertrophy following unilateral nephrectomy in mature and old rats].
One of the kidneys was removed in rats from 35 to 900 g in weight; they were then sacrificed 2, 14, 30 and 60 days after the operation. The degree of compensatory hypertrophy of the remaining kidney varied greatly in rats of different age, without decreasing in old age, however. Sixty days after the operation the weight of the hypertrophic kidney in old rats was equal to 55--93% of the weight of both kidneys in control. Hypertrophy of the kidney at any age was accompanied by an increased proliferation of the tubular cells, particularly in their proximal portion. An increase in the size of renal bodies during kidney hypertrophy was characteristic of rats of any age. However, with the advance of age this process developed more rapidly and was stronger. At any periods of investigation the hypertrophic kidney in rats of any age contained a greater number (1 1/2--2 times more) of "open" renal bodies in comparison with the kidney of intact rats.
D000367:Age Factors; D000818:Animals; D005260:Female; D006984:Hypertrophy; D007668:Kidney / Q000473:pathology*; D008297:Male; D009392:Nephrectomy; D051381:Rats
Sravnitel'naia kharakteristika kompensatornoĭ gipertrofii pockhi posle odnostoronneĭ nefréktomii u krys zrelogo i starcheskogo vozrasta