title: Aortic endothelial and sub-endothelial lesions in early stages of experimental atherogenesis and in scurvy.
abstract: The endothelial and sub-endothelial lesions during early stages of experimental atherogenesis and scurvy have been studied by means of scanning EM and transmission EM, making use also of the Con-A reaction. The surface coat modifications were accompanied by formation of vacuoles in the endothelial cells and by sub-endothelial 'oedema', not only in rabbits fed a hypercholesterolic diet but also in scorbutic guinea pigs. The endothelial lesions were sometimes found even before clear modifications of the Con-A surface reactive layer were apparent.
mesh_terms: D000818:Animals; D001011:Aorta / Q000473:pathology* / Q000648:ultrastructure; D001018:Aortic Diseases / Q000473:pathology*; D001161:Arteriosclerosis / Q000473:pathology*; D004036:Diet, Atherogenic; D004727:Endothelium / Q000473:pathology / Q000648:ultrastructure; D006168:Guinea Pigs; D011817:Rabbits; D011952:Receptors, Concanavalin A; D012614:Scurvy / Q000473:pathology*; D014617:Vacuoles / Q000648:ultrastructure
chemical_list: D011952:Receptors, Concanavalin A