Nicotine-11C: synthesis and distribution kinetics in animals.
In order to study "in vivo" the distribution kinetics of (-)-nicotine in animals, this molecule was labeled with carbon-11. Two synthesis methods are described. Immediately after intravenous administration of (-)-nicotine-methyl-11C in rabbits the gamma-camera shows a strong radioactivity build-up in the brain and kidneys. The biological interest of this carbon-11 labeled molecule is discussed.
D000818:Animals; D001345:Autoradiography; D001921:Brain / Q000378:metabolism; D002250:Carbon Radioisotopes / Q000378:metabolism; D007553:Isotope Labeling; D007668:Kidney / Q000378:metabolism; D051379:Mice; D009538:Nicotine / Q000031:analogs & derivatives / Q000138:chemical synthesis / Q000378:metabolism; D011817:Rabbits; D014018:Tissue Distribution
D002250:Carbon Radioisotopes; D009538:Nicotine