Effect of repeated halothane anesthesias on Syrian hamster lung lipids.
Sixteen adult Syrian hamsters were exposed 33 times over a 19-day period to enough halothane to induce a deep surgical plane of anesthesia. The exposures caused no significant change in the total amount of lipid in the exposed lungs; however, the percentage of neutral lipid due to cholesterol increased from 29 +/- 5% to 43 +/- 7% while the percentage of free fatty acid decreased from 33 +/- 3% to 22 +/- 5%. Among the phosphoglycerides, there was a slight shift toward more phosphatidyl choline and less phosphatidyl serine, phosphatidyl glycerol, and phosphatidyl ethanolamine.
D000769:Anesthesia, Inhalation / Q000662:veterinary*; D000818:Animals; D006224:Cricetinae / Q000378:metabolism*; D005230:Fatty Acids, Nonesterified / Q000378:metabolism; D006221:Halothane / Q000494:pharmacology*; D050356:Lipid Metabolism; D008168:Lung / Q000187:drug effects* / Q000378:metabolism; D008647:Mesocricetus / Q000378:metabolism*; D010743:Phospholipids / Q000378:metabolism
D005230:Fatty Acids, Nonesterified; D010743:Phospholipids; D006221:Halothane