Pharmacological protection of hypoxic heart.
The ability of beta-adrenoceptor antagonists, with and without intrinsic sympathomimetic activity, and of verapamil to protect the heart against hypoxia-induced damage was investigated. Damage was quantitated in terms of a raised end-diastolic resting tension and creatine phosphokinase (CPK) release. The results indicate that both the d and the l isomers act differently, the isomers preventing CPK release and the d isomers preventing the increase in resting tension.
D000818:Animals; D006168:Guinea Pigs; D006321:Heart / Q000187:drug effects; D000860:Hypoxia / Q000473:pathology*; D008854:Microscopy, Electron; D009206:Myocardium / Q000473:pathology* / Q000648:ultrastructure; D011217:Practolol / Q000494:pharmacology*; D011433:Propranolol / Q000494:pharmacology*; D011817:Rabbits; D014700:Verapamil / Q000494:pharmacology*
D011433:Propranolol; D014700:Verapamil; D011217:Practolol