Therapeutic effects of some cholinolytics in organophosphate intoxications.
The therapeutic effects of pipethanate (sycotrol) and two newly synthetized cholinolytics, DPX-8 and ANC-51, were compared with atropine in mice poisoned by DDVP, fluostigmine, phospholine, and paraoxon. The antagonistic activotagonistic activity of tested drugs against acetylcholine-induced contraction of rat ileum and oxotremorine-induced salivation and tremor in the mouse was also studied. The anticholinergic activity of pipethanate, DPX-8, and ANC-51 was weaker than that of atropine. However,the therapeutic effect of pipethanate was higher than that of atropine in mice poisoned by the organophosphates. DPX-8 and ANC-51 afforded a better antidotal effect than atropine only in DDVP-poisoned mice.
D000818:Animals; D000931:Antidotes; D001285:Atropine / Q000627:therapeutic use; D001561:Benzilates / Q000627:therapeutic use; D004006:Dichlorvos / Q000506:poisoning; D004456:Echothiophate Iodide / Q000506:poisoning; D007531:Isoflurophate / Q000506:poisoning; D007928:Lethal Dose 50; D051379:Mice; D009130:Muscle, Smooth / Q000187:drug effects; D062025:Organophosphate Poisoning; D010095:Oxotremorine / Q000037:antagonists & inhibitors; D010261:Paraoxon / Q000506:poisoning; D010276:Parasympatholytics / Q000627:therapeutic use*; D010880:Piperidines / Q000627:therapeutic use; D051381:Rats
D000931:Antidotes; D001561:Benzilates; D010276:Parasympatholytics; D010880:Piperidines; D007531:Isoflurophate; C013345:2,2-diphenyl-4-piperidinomethyl-1,3-dioxolane; D010095:Oxotremorine; D001285:Atropine; D004006:Dichlorvos; D004456:Echothiophate Iodide; D010261:Paraoxon