[Increase in the sensitivity of leukemia cells, incubated in interferon, to the effect of immune serum].
L-1210 AND P-388 leukemic cells were incubated in three types of interferon, i.e. L-cell interferon and two types of lymphocyte interferon (induced in the lymph node lymphocytes of intact mice and the lymphocytes obtained on the 10th day after intraperitoneal injections of 5-10(7) L-1210 cells). "False" interferon obtained by the method analogous to that of obtaining L-cell interferon, excluding the viral induction, was used for control. Cells incubated in interferon proved to be more sensitive to the action of the cytotoxic antibodies than those treated with "false" interferon. Treatment of the cells with lymphocytic interferon induced on the lymphocytes of immune mice increased their sensitivity even more in comparison with the cells treated with interferon obtained from intact mice.
D000818:Animals; D005260:Female; D006824:Hybridization, Genetic; D007116:Immunization, Passive; D007372:Interferons / Q000302:isolation & purification / Q000627:therapeutic use*; D007739:L Cells / Q000032:analysis; D007939:Leukemia L1210 / Q000628:therapy; D007942:Leukemia, Experimental / Q000628:therapy*; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D008811:Mice, Inbred DBA
D007372:Interferons
Povyshenie chuvstvitel'nosti leĭkoznykh kletok, inkubirovannykh v interferone, k deĭstviiu immunoĭ syvorotki