[Differential diagnosis of chronic obstructive lung disease, A statistical analysis of the discriminating power of various lung function tests (author's transl)].
Among 65 patients admitted to the hospital for chronic obstructive lung disease, the following pulmonary tests were systematically performed : spirometric vital capacity and total lung capacity, FEV1, functional residual capacity and total lung capacity measured by body plethysmography, airway resistance and specific conductance, CO diffusion capacity measured by single-breath test, N2 clearance by single breath oxygen dilution, and blood gases. The patients were divided into bronchitics, emphysematous and broncho-emphysematous, according to the clinical and radiological Nash's score, and to another personal score derived from the former. The simple and multiple correlations between the clinico-radiological score and the functional results are low. The clustering analysis groups the 65 patients into four clouds of points, around two principal axes : the volume axis and the overinflation axis. This study indicates that the most suggestive results for emphysema diagnosis are increased FRC and TLC and low Tlco/V'a. The clinical score is not dominant for the clustering of the patients into the dynamic clouds. Beneath the bronchitic, the broncho-emphysematous and the emphysematous groups, the clustering analysis individualizes a fourth group of cases characterized by chronic asthma, and which were not isolated by Nash's score.
D000403:Airway Resistance; D001249:Asthma / Q000175:diagnosis; D001784:Blood Gas Analysis; D001991:Bronchitis / Q000175:diagnosis; D002248:Carbon Monoxide; D003937:Diagnosis, Differential; D005069:Evaluation Studies as Topic; D005541:Forced Expiratory Volume; D006801:Humans; D008173:Lung Diseases, Obstructive / Q000175:diagnosis*; D008176:Lung Volume Measurements; D008875:Middle Aged; D010991:Plethysmography; D011653:Pulmonary Diffusing Capacity; D011656:Pulmonary Emphysema / Q000175:diagnosis; D012115:Residual Volume; D012129:Respiratory Function Tests; D013147:Spirometry; D014797:Vital Capacity
D002248:Carbon Monoxide
Diagnostic différentiel des bronchopneumopathies obstructives chroniques. Etude statistique du pouvoir discriminatoire de diverses épreuves fonctionnelles respiratoires