title: Determination of the nonnutritive sweetener sodium cyclopentylsulfamate and three of its metabolites, cyclopentylamine, cyclopentanone, and cyclopentanol, in urine of rats and rabbits.
abstract: The nonnutritive sweetener sodium cyclopentylsulfamate was fed to Wistar albino rats and New Zealand White rabbits. Urine was collected for 3 days after feeding, combined, and examined for the metabolites cyclopentylamine, cyclopentanone, and cyclopentanol and for sodium cyclopentylsulfamate was assayed by hydrolysis in acidified dioxane-water and subsequent measurement of the absorbance of the product formed (lambdamax = 490 nm) by the liberated amine with p-benzoquinone. The average conversion to cyclopentylamine, cyclopentanone, and cyclopentanol was 0.103, 0.171, and 0.054% in the rabbit and 0.057, 0.016, and 0.008% in the rat, respectively.
mesh_terms: D000588:Amines / Q000652:urine; D000818:Animals; D002849:Chromatography, Gas; D003494:Cyclamates / Q000652:urine*; D003517:Cyclopentanes / Q000652:urine; D005260:Female; D007659:Ketones / Q000652:urine; D008027:Light; D008722:Methods; D011817:Rabbits; D051381:Rats; D013053:Spectrophotometry; D013549:Sweetening Agents / Q000652:urine*
chemical_list: D000588:Amines; D003494:Cyclamates; D003517:Cyclopentanes; D007659:Ketones; D013549:Sweetening Agents; C016327:cyclopentanol; C007201:cyclopentanone; C016329:cyclopentylamine