Pharmacokinetic data on tritium labelled ethyl apovincaminate.
Absorption, tissue distribution and excretion of tritium labelled ethyl apovincaminate (RGH-4405, Cavinton) were studied. Both oral and i.p. administration resulted in a relatively rapid elimination of tritium activity, suggesting that neither the original drug nor its metabolites remained in the organism of rat. 50% of radioactivity was recovered in urine and 30% in faeces during 48 h. At this time only liver and kidneys contained measurable quantities of radioactivity among the organs tested. Biliary route of elimination seemed to be important, since 20% and 4% of radioactivity appeared in bile during 9 h following i.p. and p.o. administration, respectively. Enterohepatic circulation was of no consequence. Radioactivity was hardly adsorbed to or absorbed by blood cells and was almost completely bound by plasma protein(s).
D000284:Administration, Oral; D000818:Animals; D001646:Bile / Q000378:metabolism; D001773:Blood Cells / Q000378:metabolism; D001798:Blood Proteins / Q000378:metabolism; D004764:Enterohepatic Circulation; D005260:Female; D007274:Injections, Intraperitoneal; D007700:Kinetics; D008297:Male; D011485:Protein Binding; D051381:Rats; D014665:Vasodilator Agents; D014748:Vinca Alkaloids / Q000008:administration & dosage / Q000378:metabolism*
D001798:Blood Proteins; D014665:Vasodilator Agents; D014748:Vinca Alkaloids