title: Effect of the hepatocarcinogen ethionine on hepatic messenger RNA synthesis.
abstract: An experiment was conducted to determine if any changes resulted in the proportion of hepatic messenger RNA following treatment with ethionine, a hepatocarcinogen. The relative specific activity of the total RNA isolated from nontumor-like tissues was increased in Sprague-Dawley rats fed ethionine. However, the percentage of total RNA that was message was found to be decreased in the ethionine-treated rats.
mesh_terms: D000818:Animals; D002273:Carcinogens; D005001:Ethionine / Q000494:pharmacology*; D008099:Liver / Q000187:drug effects / Q000378:metabolism*; D008297:Male; D011061:Poly A / Q000378:metabolism; D012333:RNA, Messenger / Q000096:biosynthesis*; D051381:Rats; D014158:Transcription, Genetic / Q000187:drug effects
chemical_list: D002273:Carcinogens; D012333:RNA, Messenger; D011061:Poly A; D005001:Ethionine