[Action of acetylsalicylic acid administered by different routes on the blood and buccal tissues of rats].
Sixty female Sprague-Dawley rats, with an average weight of 120 g, have been used in this study. The experimental groups received twice a day 1 ml of a 2% acetyl-salicylic acid suspension in methyl-cellulose either per os or i.p. The control groups received methyl-cellulose without asprin. The blood was collected before any treatment and each day during the week for the purpose of counting cells. The experimental animals and their control were killed after 2, 4 and 8 days. A piece of endobuccal epithelium with its deeper tissues was cut off and frozen for histochemistry. The tissue sections were treated to show the basic enzymatic reactions of the cell. It was observed that: 1. most of the changes appear between the 4th and 8th day of the treatment: 2. depending on the administration route, certain blood cells show a peak. Microphages between the 4th and 6th day in injected animals. Lymphocytes at the same time, in the gavage group; 3. oral epithelium lesions are limited and appear lately; 4. underlying muscles are a constant target. The lesions are seen in both experimental groups as soon as the 2nd day. After a week, the lesions are more numerous. They are characterized by enzymatic inbalances with or without macrophages. The muscular cell is a real target for acetyl salicylic acid.
D000284:Administration, Oral; D000818:Animals; D001241:Aspirin / Q000008:administration & dosage / Q000633:toxicity*; D001773:Blood Cells / Q000187:drug effects*; D002610:Cheek; D005260:Female; D007274:Injections, Intraperitoneal; D009061:Mouth Mucosa / Q000187:drug effects*
D001241:Aspirin
Action de l'acide acétyl-salicylique administré par différentes voies sur les tissus sanguin et buccaux du rat