[Role of surface phenomena in the mechanism of action of antiarrhythmic substances].
The surface activity of the antiaarhythmic drugs and their influence on the lipid-containing interphasics were studied. It was found that drug No. 7351 (diphenyl isopropyl acetic acid diethyl aminopropyl ester), fubromegan, metamysil, propranolol, quinidine, novocalinamide, xylocaine, and trimecaine possessed surface activity. There exists a symbate relationship between the surface and especially the interphasic activity and the antiarrhythmic effect. The most active antiarrhythmic drug No. 7351 increased the electric conductivity of the lecithine bilayer membrane much more than novocainamide.
D000818:Animals; D000889:Anti-Arrhythmia Agents / Q000494:pharmacology* / Q000627:therapeutic use; D001145:Arrhythmias, Cardiac / Q000188:drug therapy; D002415:Cats; D004553:Electric Conductivity; D008567:Membranes, Artificial; D010713:Phosphatidylcholines
D000889:Anti-Arrhythmia Agents; D008567:Membranes, Artificial; D010713:Phosphatidylcholines
Rol' poverkhnostnykh iavleniĭ v mekhanizme deĭstviia protivoaritmicheskikh veshchestv