A case report including EM and DNA repair investigations in a dermatosis associated with multiple skin cancers: epidermodysplasia verruciformis.
This report describes the clinical, histological and electron microscopic observations in a 51-year-old male with epidermodysplasia veruciformis (EV). Cells with early signs of malignant transformation were found closely connected with virus infected epidermal regions. Skin cancers appeared initially on sun-exposed areas, such as the face and ear lobes. The UV-induced DNA repair synthesis was therefore studied, utilizing peripheral leukocytes. The patient had 40% lower UV-induced DNA repair synthesis than the mean of nine healthy subjects of the same age. These results suggest that a decrease in UV-induced DNA repair synthesis in combination with a possibly oncogenic viral infection may enhance the disposition for somatic mutations and malignant transformation in patients with EV.
D004260:DNA Repair / Q000528:radiation effects; D006801:Humans; D066298:In Vitro Techniques; D007962:Leukocytes / Q000378:metabolism / Q000528:radiation effects; D008297:Male; D008875:Middle Aged; D009378:Neoplasms, Multiple Primary / Q000473:pathology*; D012867:Skin / Q000473:pathology / Q000648:ultrastructure; D012871:Skin Diseases / Q000150:complications* / Q000378:metabolism / Q000473:pathology; D012878:Skin Neoplasms / Q000150:complications* / Q000378:metabolism / Q000648:ultrastructure; D014466:Ultraviolet Rays