Maternal diabetes mellitus and congenital malformation. Survey of 205 cases.
Twenty-five out of 205 (i.e. 12%) babies born to diabetic mothers in the Birmingham Maternity Hospital in the period 1969-1974 were malformed as against 6% in a control group. The incidence was highest in the group where mothers were on insulin at the time of conception (17 out of 117, i.e. 15%). No correlation was observed between major malformation in this group and age of onset or duration of the diabetes, progressive vascular complications, maternal age, or parity. Cardiovascular malformations were over-represented.
D000014:Abnormalities, Drug-Induced / Q000453:epidemiology; D000328:Adult; D000013:Congenital Abnormalities / Q000453:epidemiology*; D048909:Diabetes Complications; D004739:England; D005260:Female; D005313:Fetal Death / Q000453:epidemiology; D006801:Humans; D007231:Infant, Newborn; D007328:Insulin / Q000009:adverse effects; D008431:Maternal-Fetal Exchange; D011247:Pregnancy; D011254:Pregnancy in Diabetics / Q000150:complications*
D007328:Insulin