Congenital retarded myelinization in a new-born child with infantile spasms.
A new-born child with frequent infantile spasms was investigated. In a cachectic state it died at the age of 11 months. Biopsy of the cerebral cortex revealed a retarded myelinization; at autopsy this slight myelinization was found again. The ganglioside pattern suggested a developmental stage of approximately 3 months before birth. This is a case with a congenital failure of myelinization.
D001344:Autopsy; D002540:Cerebral Cortex / Q000473:pathology; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007232:Infant, Newborn, Diseases / Q000209:etiology* / Q000473:pathology; D008297:Male; D009186:Myelin Sheath / Q000473:pathology; D013036:Spasms, Infantile / Q000209:etiology* / Q000473:pathology