[Lipid peroxidation and disturbance in Ca2+ transport through sarcoplasmic reticulum membranes during E-avitaminosis].
The antioxidant effect of alpha-tocopherol in biolgoical membranes in vivo is described. Experimental E-avitaminosis is accompanied by accumulation of products of free-radical oxidation of phospholipids and by a loss of Ca2+-transporting ability of the muscle cells microsomal fraction. The role of alpha-tocopherol in stabilization and as a "radical trap" in biological membranes is discussed.
D000975:Antioxidants / Q000378:metabolism; D001692:Biological Transport; D002118:Calcium / Q000378:metabolism*; D004355:Drug Stability; D005609:Free Radicals; D050356:Lipid Metabolism; D008861:Microsomes / Q000378:metabolism; D010084:Oxidation-Reduction; D010545:Peroxides / Q000378:metabolism; D012519:Sarcoplasmic Reticulum / Q000378:metabolism*; D014810:Vitamin E / Q000502:physiology; D014811:Vitamin E Deficiency / Q000378:metabolism*
D000975:Antioxidants; D005609:Free Radicals; D010545:Peroxides; D014810:Vitamin E; D002118:Calcium
Perekisnoe okislenie lipidov i narushenie transporta Ca2+ cherez membrany sarkoplazmaticheskogo retikuluma pri E- avitaminoze