Comparative studies of the humoral and arterial pressure responses to Sar1-Ala8-, Sar1-Ile8 and Sar1-Thr8-angiotensin II in the trained unanaesthetized dog.
The humoral and arterial blood pressure responses to Sar1-Ala8-, Sar1-Ile8- and Sar1-Thr8-angiotensin II were studied in sodium-depleted, trained, unanaesthetized dogs. Of the three angiotensin antagonists, Sar1-Thr8-angiotensin II appeared to be the best suited for clinical use. In the smallest amount that was found to be effective in reducing arterial pressure, it was devoid of agonist activity. Also, in marked contrast to Sar1-Ala8- and Sar1-Ile8-angiotensin II, Sar1-Thr8-angiotensin II was not shown to stimulate either catecholamine or aldosterone secretion.
D000450:Aldosterone / Q000097:blood; D000804:Angiotensin II / Q000031:analogs & derivatives* / Q000037:antagonists & inhibitors / Q000494:pharmacology; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects*; D004285:Dogs; D004305:Dose-Response Relationship, Drug; D008297:Male; D012083:Renin / Q000097:blood / Q000378:metabolism; D012504:Saralasin / Q000494:pharmacology*; D012964:Sodium / Q000502:physiology; D013329:Structure-Activity Relationship; D013997:Time Factors
D000804:Angiotensin II; D000450:Aldosterone; D012964:Sodium; D012083:Renin; D012504:Saralasin