Effects of cinepazide, a new vasoactive substance, on heart and circulation in the dog.
The authors report on the action of a new drug, 1-(pyrrolidinyl-1-carbonyl)-methyl-4-(3,4,5-trimethoxycinnamoyl)-piperazine-maleate (cinepazide), on the heart and systemic and coronary circulation. At doses of 1--3 mg/kg i.v. (n=6), systemic blood pressure decreased by 4%, and heart rate increased reflexly by 8%...
D000818:Animals; D002934:Cinnamates / Q000008:administration & dosage / Q000494:pharmacology; D003326:Coronary Circulation / Q000187:drug effects*; D004285:Dogs; D004305:Dose-Response Relationship, Drug; D005260:Female; D006439:Hemodynamics / Q000187:drug effects*; D008297:Male; D009200:Myocardial Contraction / Q000187:drug effects; D009206:Myocardium / Q000378:metabolism; D010101:Oxygen Consumption / Q000187:drug effects; D010879:Piperazines / Q000008:administration & dosage / Q000494:pharmacology*; D011759:Pyrrolidines / Q000008:administration & dosage / Q000494:pharmacology*; D014665:Vasodilator Agents / Q000008:administration & dosage / Q000494:pharmacology*
D002934:Cinnamates; D010879:Piperazines; D011759:Pyrrolidines; D014665:Vasodilator Agents