[Electron microscopic study on the proliferation and regression of the human endometrium following administration of a new depot estrogen ethinyl estradiol sulfonate].
The ultrastructure of endometrium was investigated after oral application of 1 or 3 mg of the new depot oestrogen etinyloestradiolsulfonate by means of long time observation with biopsies on postmenopause women. Details of this experimental proliferation was described. The highest functional activity in the endometrial gland and stromal cells was found 3 weeks after intake. There was no difference between ultrastructure following exogenous and endogenous oestrogen action. Degenerative changes within mitochondria were observed earlier than the regression in light microscopical picture.
D003692:Delayed-Action Preparations; D004717:Endometrium / Q000187:drug effects* / Q000648:ultrastructure; D004997:Ethinyl Estradiol / Q000008:administration & dosage* / Q000031:analogs & derivatives; D005260:Female; D006801:Humans; D008593:Menopause; D008875:Middle Aged; D008928:Mitochondria / Q000648:ultrastructure
D003692:Delayed-Action Preparations; D004997:Ethinyl Estradiol
Elektronenmikroskopische Untersuchung der Proliferation und Regression des menschlichen ENDOMETRIUMS NACH Applikation des neuen Depotöstrogens Athinylöstradiolsulfonat