title: Studies on experimental coronary insufficiency. II. Effects of beta-adrenergic blocking agent (propranolol) on metabolic response to adrenaline and noradrenaline in dogs with coronary constriction.
abstract: To obtain further information on the mechanism by which catecholamines produce myocardial ischemia, the effects of propranolol on metabolic and mechanical responses to adrenaline or noradrenaline were investigated in coronary-constricted dogs. Propranolol suppressed the myocardial ischemia produced by noradrenaline and adrenaline in dogs with moderate coronary constriction.
mesh_terms: D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D003250:Constriction; D003327:Coronary Disease / Q000378:metabolism*; D003331:Coronary Vessels / Q000502:physiology*; D004285:Dogs; D004837:Epinephrine / Q000494:pharmacology*; D006321:Heart / Q000187:drug effects; D007773:Lactates / Q000378:metabolism; D009206:Myocardium / Q000378:metabolism*; D009638:Norepinephrine / Q000494:pharmacology*; D010101:Oxygen Consumption / Q000187:drug effects; D011433:Propranolol / Q000494:pharmacology*
chemical_list: D007773:Lactates; D011433:Propranolol; D009638:Norepinephrine; D004837:Epinephrine