Effects of ethyl apovincaminate on the central nervous system.
Side effects of ethyl apovincaminate (RGH-4405, Cavinton), a cerebral vasodilatory agent, on the central nervous system were studied on mice and rats. Anticonvulsive effect in electroshock was observed as major CNS effect, locomotor activity was reduced due to muscle relaxant effect. The compound had no sedative effect on rodents. Its analgesic effect was negligible. Cavinton had neither antidepressive, nor anticholinergic activity.
D000818:Animals; D001921:Brain / Q000187:drug effects*; D005260:Female; D006591:Hexobarbital; D007928:Lethal Dose 50; D008297:Male; D051379:Mice; D009043:Motor Activity / Q000187:drug effects; D051381:Rats; D012640:Seizures / Q000517:prevention & control; D012890:Sleep / Q000187:drug effects; D014665:Vasodilator Agents; D014748:Vinca Alkaloids / Q000494:pharmacology*
D014665:Vasodilator Agents; D014748:Vinca Alkaloids; D006591:Hexobarbital