[Heinz body formation and abnormal methemoglobin reduction. Expressions of damage to erythrocytes in chronic kidney failure].
Erythrocytes of patients dialyzed due to chronic renal failure were investigated. An inhibition of the NADH-dependent methaemoglobin reductase, an insufficient methaemoglobin reduction by the NADPH-system, and Heinz-bodies as denaturation products, were found. The damage of erythrocytes was enhanced by incubation in both patient's plasma and dialysis medium. In erythrocytes of normal persons the damaging effect of incubation in plasma of chronic renal failure patients could also be demonstrated. The factors eliciting the oxidative injury are discussed. Factors that could further decrease the reduction capacity of red cells should be omitted.
D000328:Adult; D042966:Cytochrome-B(5) Reductase / Q000378:metabolism; D004912:Erythrocytes / Q000378:metabolism*; D005260:Female; D005978:Glutathione / Q000097:blood; D006366:Heinz Bodies; D006801:Humans; D007676:Kidney Failure, Chronic / Q000097:blood*; D008297:Male; D008706:Methemoglobin / Q000378:metabolism*; D008875:Middle Aged; D006435:Renal Dialysis
D008706:Methemoglobin; D042966:Cytochrome-B(5) Reductase; D005978:Glutathione
Heinzkörperbildung und gestörte Met Hb-reduktion Ausdruck der Schädigung von Erythrozyten bei chronischer Niereninsuffizienz