title: Effect of the ligation of hepatic artery on the microcirculation in the cirrhotic liver in the rat.
abstract: The significance of the hepatic arterial supply in the intrahepatic microcirculation in normal and carbon tetrachloride-induced cirrhotic livers was studied by dye injection method and by ligation of the hepatic artery. The in vivo distribution of dye injected into the hepatic artery evidenced the presence of arterio-venous shunts in the cirrhotic liver. When the hepatic artery of the cirrhotic liver was ligated, the elevated portal venous pressure dropped significantly, and the fast-flowing population of microvessels and sinusoids in the bimodal frequency distribution plot disappeared. The fast-flowing microvessel and sinusoids appeared to be the "arterial" microvessels and sinusoids, and they were converted into the slow-flowing venous channels after hepatic arterial ligation. The transmission of arterial pressure via the A-V shunts may be of greater significance in the pathophysiology of portal hypertension than previously believed.
mesh_terms: D000818:Animals; D001164:Arteriovenous Fistula / Q000503:physiopathology; D001783:Blood Flow Velocity; D001794:Blood Pressure; D004912:Erythrocytes; D006499:Hepatic Artery / Q000503:physiopathology*; D006975:Hypertension, Portal / Q000209:etiology; D008026:Ligation; D008102:Liver Circulation; D008106:Liver Cirrhosis, Experimental / Q000150:complications / Q000503:physiopathology*; D008297:Male; D008833:Microcirculation; D011169:Portal Vein / Q000503:physiopathology; D051381:Rats