[ST-line and T-wave changes unter influence of different digitalis doses within the therapeutic range (studies of patients with stress coronary insufficiency)].
ST-segmental depression below the isoelectric line in the ECG occurring under a therapy of sub-therapeutical and therapeutical digitalising doses, very often involves an increase of pre-existent stress stenocardia with cardiovascularily compensated patients having a coronary heart disease. For this purpose, 13 patients of both sexes with latent coronary insufficiency were examined. The patients were treated with beta-Acetyldigoxin i.v. and were controlled under bicycle ergometric test-conditions before as well as during the different saturation phases with digitalis (0.66 +/- 0.03 mg, 1.20 +/- 0.07 mg and 1.54 +/- 0.10 mg beta-Acetyldigoxin) in a miximum of 4 functional tests alltogether. Dose-depent depression of the ST-segment accurred regularly accompanied by a reduction of the T-wave amplitude. A comparative valuation of myocardischemic and glycoside conditioned repolarisation disorders in the ECG demonstrated formalanalytically no differences concerning differential diagnosis. With the appearance of digitalis conditioned ST-T-changes an increase of angina pectoris could be proved. There were hints that the so-called adhesive signs of digitalis are an expression of myocardial ischemia and therefore principally of diagnostic value.
D000368:Aged; D003327:Coronary Disease / Q000175:diagnosis / Q000188:drug therapy*; D004077:Digoxin / Q000008:administration & dosage / Q000031:analogs & derivatives*; D004562:Electrocardiography; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D005082:Physical Exertion
D004077:Digoxin
ST-Strecken- und T-Wellenveränderungen unter dem Einfluss unterschiedlicher Digitalisdosen im therapeutischen Bereich (Untersuchungen bei Patienten und Belastungskoronarinsuffizienz)