title: Acquisition of human blood group antigens by Schistosoma mansoni.
abstract: Juvenile forms of Schistosoma mansoni (schistosomula) have been cultured in human blood of various specificities and tested for the presence of blood group substances on their surfaces. The tests employed were survival following transfer into rhesus monkeys immunized against human blood substances, mixed agglutination reactions, and immunofluorescence. A, B, H AND Lewisb+ antigens were expressed at the surface when the parasites were cultured in blood of appropriate specificities. Rhesus, M N S, AND Duffy antigens could not be detected on the parasite surface following culture. The evidence suggests that the expressed blood group antigens are of host origin and are acquired by the parasite during culture, probably in the form of glycolipids or megaloglycolipids. It is likely that these substances are also acquired by parasites in the bloodstream of man. They may serve to mask surface parasite antigens, and so enable schistosomes to evade parasite-specific humoral or cellular immune responses.
mesh_terms: D000017:ABO Blood-Group System; D000372:Agglutination Tests; D000818:Animals; D000941:Antigens; D001665:Binding Sites; D001789:Blood Group Antigens; D006801:Humans; D007114:Immunization; D008253:Macaca mulatta / Q000276:immunology; D012550:Schistosoma mansoni / Q000276:immunology*
chemical_list: D000017:ABO Blood-Group System; D000941:Antigens; D001789:Blood Group Antigens