title: The development of an acute tolerance to ketamine.
abstract: A rapidly developing tolerance to the hypnotic effect of ketamine in rats and mice has been investigated. On the basis of plasma and brain concentrations of ketamine at the time the animals wakened, it seemed likely that a central nervous system tolerance to the drug explained the shortened sleeping times noted.
mesh_terms: D000818:Animals; D002490:Central Nervous System / Q000187:drug effects; D004361:Drug Tolerance; D007649:Ketamine / Q000378:metabolism / Q000494:pharmacology; D008297:Male; D051379:Mice; D051381:Rats; D013997:Time Factors
chemical_list: D007649:Ketamine