title: Delayed ovulation and monozygotic twinning.
abstract: Aiming to show that delayed ovulation may induce MZ twinning, follicular maturation was induced in the rabbit by a small quantity of Pregnant Mare Serum Gonadotropin (16 UI four times): coitus, which induces ovulation in the rabbit, was delayed 60 hours after the last injection. From the 387 blastocysts obtained after this treatment, 6 (1.5%) were pairs of MZ twins, twinning being otherwise exceptional in the rabbit. Other anomalies were shown by the embryos, apparently related to a deficient quality of the eggs: high embryonic mortality (62% vs. 27% in controls) and chromosomal anomalies (20%) such as trisomies, triploidies, and chimaeras. The relation between MZ twinning, chromosomal anomalies, and embryonic mortality induced by delayed ovulation, could be connected and related to the poor perinatal conditions frequently observed in human MZ twins.
mesh_terms: D000818:Animals; D002470:Cell Survival; D002869:Chromosome Aberrations / Q000196:embryology; D025063:Chromosome Disorders; D003643:Death; D004195:Disease Models, Animal; D004200:Diseases in Twins; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D008423:Maternal Age; D008598:Menstruation; D010060:Ovulation; D010063:Ovum / Q000502:physiology; D011247:Pregnancy; D011817:Rabbits; D014427:Twins; D014430:Twins, Monozygotic