[Effect of cholinergic drugs on serotonin metabolism and emotional reactions in rats].
The effects of physostigmine and m-cholinolytics on emotional reactivity, aggressiveness, exploratory behavior, along with simultaneous influence on the endogenous serotonin metabolism, enhanced by 1-tryptophan serotonin metabolism in the brain, were studied. Upon blocking the peripheral effects with methylatropine-physostigmine exerted a tranquillizing action on emotional reactions without producing any significant changes in the serotonin metabolism. Physostigmine acted as an antagonist to the traquillizing effect of 1-tryptophan, facilitating the catabolism of serotonin. M-cholinolytics--atropine and benactyzine exercised a tranquillizing action on emotional reactions, increasing the serotonin level in the forebrain and diencephalon.
D000374:Aggression / Q000187:drug effects; D000818:Animals; D001286:Atropine Derivatives / Q000494:pharmacology*; D001522:Behavior, Animal / Q000187:drug effects; D001535:Benactyzine / Q000031:analogs & derivatives* / Q000494:pharmacology; D001921:Brain / Q000378:metabolism; D004336:Drug Antagonism; D004644:Emotions / Q000187:drug effects*; D006801:Humans; D006897:Hydroxyindoleacetic Acid / Q000378:metabolism; D008297:Male; D010830:Physostigmine / Q000494:pharmacology*; D051381:Rats; D012701:Serotonin / Q000378:metabolism*; D014364:Tryptophan / Q000037:antagonists & inhibitors / Q000378:metabolism / Q000494:pharmacology*
D001286:Atropine Derivatives; D012701:Serotonin; D006897:Hydroxyindoleacetic Acid; D001535:Benactyzine; D014364:Tryptophan; D010830:Physostigmine
Vliianie kholinergicheskikh veshchestv na obmen serotonina i emotsional'nye reaktsii krys