title: [Possible change in the substrate specificity of the monoamine oxidase of rat brain and liver mitochondria in hyperoxia].
abstract: Maintenance of animals in conditions of increased oxygen pressure at 4 atm within 1 h caused a decrease in activity of monoamine oxidase from rat brain mitochondria and liver tissue; at the same time, deamination of putrescine and AMP was increased. Deamination of glucosamine was also observed in brain mitochondria. The qualitative alterations in the monoamine oxidase activity were more distinct in brain than in liver tissue. The enzymatic activity was partially restored by addition of ascorbic acid to the suspension of mitchondria.
mesh_terms: D000249:Adenosine Monophosphate / Q000378:metabolism; D000818:Animals; D001205:Ascorbic Acid / Q000378:metabolism; D001273:Atmosphere Exposure Chambers; D001921:Brain / Q000201:enzymology*; D003641:Deamination; D004789:Enzyme Activation / Q000187:drug effects; D005944:Glucosamine / Q000378:metabolism; D006931:Hyperbaric Oxygenation; D008297:Male; D008928:Mitochondria / Q000201:enzymology*; D008930:Mitochondria, Liver / Q000201:enzymology*; D008995:Monoamine Oxidase / Q000378:metabolism*; D010100:Oxygen / Q000097:blood*; D011700:Putrescine / Q000378:metabolism; D051381:Rats; D013997:Time Factors; D014363:Tryptamines / Q000378:metabolism
chemical_list: D014363:Tryptamines; D000249:Adenosine Monophosphate; D008995:Monoamine Oxidase; D005944:Glucosamine; D001205:Ascorbic Acid; D010100:Oxygen; D011700:Putrescine
vernacular_title: O vozmozhnom izmenenii substratnoĭ spetsifichnosti monoaminoksidazy mitokhondriĭ mozga i pecheni krys pri giperoksii