Effects of calcium infusion on secretion and motor activity of totally isolated canine stomach perfused with homologous blood.
Isolated, ex vivo perfused, canine stomachs were used for this study. Gastric secretion, myoelectrical activity and mechanical activity were recorded during stimulation of gastric function with pentagastrin or histamine alone or combined with calcium gluconate. Secretagogues and calcium were infused into the gastric arterial circulation. Hypercalcemia induced significant inhibition of pentagastrin, stimulated gastric secretion, but did not affect the secretion stimulated by histamine. Hypercalcemia also induced an increase of frequency of cycles of electrical control activity and a decrease of mechanical activity of the gastric antrum. The effect of hypercalcemia on gastric motor function was similar in the nonstimulated stomach and during the infusion of secretagogues used in this experiment.
D000200:Action Potentials / Q000187:drug effects; D000818:Animals; D002118:Calcium / Q000008:administration & dosage / Q000494:pharmacology*; D004285:Dogs; D004347:Drug Interactions; D005750:Gastric Juice / Q000378:metabolism*; D005769:Gastrointestinal Motility / Q000187:drug effects*; D006632:Histamine / Q000494:pharmacology; D007269:Injections, Intra-Arterial; D010418:Pentagastrin / Q000494:pharmacology; D010477:Perfusion; D012636:Secretory Rate / Q000187:drug effects; D013270:Stomach / Q000187:drug effects*
D006632:Histamine; D010418:Pentagastrin; D002118:Calcium