title: [Anti-inflammatory effect of methylmethionine sulfonium chloride (vitamin U)].
abstract: Tests conducted on mice demonstrated that methylmethionine-sulfonium chloride (vitamin U) is capable of lowering the permeability of the skin capillaries following the action of stimulants. It greatly potentiates the antiphlogistic effect of acetylsalicylic acid, this action being more pronounced with vitamin U administered one hour before intake of acetlsaliclic acid than when both are taken simultaneously. Given in a dose of 1000 mg/kg vitamin U helps reduce exudation in aseptic serosites in rats. The antiphlogistic effect of vitamin U comes in conjunction with its ability to exercise a protective action against lesion of the gastric mucosa produced by acetylsalicylic acid.
mesh_terms: D000818:Animals; D001241:Aspirin / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use; D002199:Capillary Permeability / Q000187:drug effects; D004341:Drug Evaluation; D004357:Drug Synergism; D004359:Drug Therapy, Combination; D051379:Mice; D051381:Rats; D012700:Serositis / Q000188:drug therapy*; D012867:Skin / Q000098:blood supply; D014814:Vitamin U / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*; D014815:Vitamins / Q000627:therapeutic use*
chemical_list: D014815:Vitamins; D014814:Vitamin U; D001241:Aspirin