[Studies on the specificity of an antiserum against denaturated DNA from Sarcina maxima].
An antiserum against denatured DNA from Sarcina maxima (71% (A + T)) reacted in complement fixation tests with denatured DNA's of various sources. The serological activity of the antibodies is in correlation with the (adenine + thymine)-content of the DNA's used as antigens. Haptene inhibition tests demonstrate a preferable reaction of the antibodies with T2-sequences. The heterogeneity of DNA-antisera and the increasing specificity of such antisera, if DNA with high (A + T) or (G + C)-content served as immunogen, are discussed.
D000907:Antibodies, Bacterial / Q000302:isolation & purification; D000918:Antibody Specificity; D003168:Complement Fixation Tests; D004269:DNA, Bacterial / Q000276:immunology*; D006241:Haptens; D007106:Immune Sera / Q000494:pharmacology*; D012505:Sarcina / Q000276:immunology / Q000378:metabolism*
D000907:Antibodies, Bacterial; D004269:DNA, Bacterial; D006241:Haptens; D007106:Immune Sera
Untersuchungen zur Spezifität eines Antiserums gegen denaturierte DNS aus Sarcina maxima