Human breast carcinoma: heterotransplantation to newborn rats.
Cultured cells from a human breast carcinoma (HBC) were injected subcutaneously in newborn cortisone-treated Sprague-Dawley rats (CNBR). Tumors of predominantly epithelial nature appeared in all within 30 days, and wipespread metastases occured often. Cells cultured from these tumors rapidly produced similar tumors in CNBR. Rat-to-rat passage by implanting fragments of tumor tissue was 100% successful in CNBR. The in vivo model described is simple and inexpensive.
D000818:Animals; D000831:Animals, Newborn; D001943:Breast Neoplasms / Q000473:pathology; D002460:Cell Line; D005260:Female; D006801:Humans; D009368:Neoplasm Transplantation; D051381:Rats; D014183:Transplantation, Heterologous; D014184:Transplantation, Homologous