title: [Drug-induced immune tolerance to sheep erythrocytes in mice of different lines].
abstract: Immunological tolerance to sheep erythrocytes was induced in mice of the CBA, C57BL/6, CC57BR, C3H, DBA/2 lines by means of combined administration of a high dose of the antigen and cyclophosphamide. The count of 19S antibody-forming cells was determined in the mouse spleen after the test injection of erythrocytes, by local hemolysis in gel. The extent of the tolerance induced proved to depend on the genotype of the animals; mice of the DBA/2 line were found to be most "sensitive" to its induction. There was revealed no correlation between the level of the immunological reactivity to sheep erythrocytes in the intact mice of different lines and the extent of its suppression in tolerance induction
mesh_terms: D000818:Animals; D003520:Cyclophosphamide / Q000494:pharmacology*; D005838:Genotype; D006824:Hybridization, Genetic; D007108:Immune Tolerance; D008297:Male; D051379:Mice; D008809:Mice, Inbred C3H; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D008811:Mice, Inbred DBA; D013045:Species Specificity
chemical_list: D003520:Cyclophosphamide
vernacular_title: Lekarstvenno indutsirovannaia immunologicheskaia tolerantnost' k éritrotsitam barana u mysheĭ raznykh liniĭ