[Adenosine degradation in human erythrocytes in the presence of dilazep].
1. In the molar end concentration of 1 X 10(-6), 1,4-bis-[3-(3,4,5-trimethoxybenzoyloxy)-propyl]-perhydro-1,4-diazepine (dilazep) has no effect on crystalline adenosine desaminase. 2. In the same concentration dilazep does not affect adenosine desaminase activity of human hemolysing erythrocytes. 3. Under the influence of dilazep the methylene blue activated respiration of human erythrocytes is inhibited adenosine serving as substrate. a) The final molar concentration of 1 X 10(-7) leads to minor inhibition of the respiration. b) After transitory activation, final molar concentrations of 1 X 10(-6) and 1 X 10(-5) also lead to inhibition, which is complete after 4 h and in which the concentration of 1 X 10(-6) has the most pronounced effect. 4. Basing on the experimental results obtained it is not yet possible to classify the mode of activity of dilazep.
D000241:Adenosine / Q000097:blood*; D000243:Adenosine Deaminase / Q000097:blood; D001381:Azepines / Q000494:pharmacology*; D004109:Dilazep / Q000494:pharmacology*; D004912:Erythrocytes / Q000378:metabolism*; D006801:Humans; D008751:Methylene Blue; D010101:Oxygen Consumption / Q000187:drug effects
D001381:Azepines; D000243:Adenosine Deaminase; D004109:Dilazep; D000241:Adenosine; D008751:Methylene Blue
Zum Adenosinabbau in menschlichen Erythrozyten in Gegenwart von Dilazep