Comparative effects of uredofos, niclosamide, and bunamidine hydrochloride against tapeworm infections in dogs.
A single dose of a new broad-spectrum anthelmintic, uredofos, was more effective than single doses of either bunamidine hydrochloride (HCI) or niclosamide in removing natural infections of Dipylidium coninum from pound dogs, as determined by necropsy examination for scolices. The efficacy of uredofos was equal to that of bunamidine HCI and exceeded that of niclosamide in removing Taenia spp from his host. All of 12 dogs harboring D caninum and all of 5 dogs harboring Taenia spp were completely cleared of tapeworm infection following treatment with uredofos at 50 mg/kg of body weight. Bunamidine HCl cleared 9 of 11 dogs (82%) of D caninum and 5 of 5 dogs of Taenia spp. Niclosamide had the least anticestodal activity of the 3 drugs; 2 or more scolices of D caninum were found at necropsy in each of 12 dogs treated with this drug. Four of 5 dogs were cleared of Taenia spp following niclosamide therapy. Untreated control dogs did not shed tapeworms of either species during a 3-day period of posttreatment fecal collections, but did have tapeworms at the time of necropsy.
D000578:Amidines / Q000627:therapeutic use*; D000818:Animals; D000871:Anthelmintics / Q000627:therapeutic use*; D002590:Cestode Infections / Q000188:drug therapy / Q000662:veterinary*; D004283:Dog Diseases / Q000188:drug therapy*; D004285:Dogs; D005260:Female; D008297:Male; D009534:Niclosamide / Q000627:therapeutic use*; D009943:Organophosphorus Compounds / Q000627:therapeutic use*; D013622:Taeniasis / Q000188:drug therapy / Q000662:veterinary
D000578:Amidines; D000871:Anthelmintics; D009943:Organophosphorus Compounds; D009534:Niclosamide; C012545:uredofos