Self-administration of caffeine by the rat.
Rats with permanently implanted right jugular vein cannulae were either pre-treated with increasing doses of caffeine for up to 98 h, or underwent no pre-treatment. Both groups were then presented with a lever, the pressing of which caused a self-injection of a caffeine solution. For both groups, some of the rats self-administered caffeine for up to 4 days and then their activity stopped; the other rats did not self-administered caffeine.
D000818:Animals; D002110:Caffeine / Q000008:administration & dosage*; D005260:Female; D006801:Humans; D011292:Premedication; D051381:Rats; D012646:Self Administration; D019966:Substance-Related Disorders
D002110:Caffeine