Increase in membrane conductance and positive inotropic action of hemolysin produced by Vibrio parahaemolyticus on rabbit myocardium.
The effects of purified thermostable direct hemolysin from the cultured filtrate of Vibrio parahaemolyticus on both S-A node cells and atrial cells were studied electrophysiologically. Hemolysin caused the membrane conductance to increase, thereby causing membrane depolarization. The major ion responsible for this depolarization was Na+, but other ions, such as K+ and Ca2+, also participated. Positive inotropic action of hemolysin was observed, and the Na-Ca exchange mechanism was enhanced after hemolysin treatment.
D000200:Action Potentials / Q000187:drug effects; D000818:Animals; D016275:Atrial Function; D001427:Bacterial Toxins / Q000494:pharmacology*; D006321:Heart / Q000187:drug effects / Q000502:physiology*; D006460:Hemolysin Proteins / Q000494:pharmacology*; D008564:Membrane Potentials / Q000187:drug effects; D009200:Myocardial Contraction / Q000187:drug effects*; D011817:Rabbits; D012849:Sinoatrial Node / Q000502:physiology; D012964:Sodium / Q000494:pharmacology; D014736:Vibrio parahaemolyticus
D001427:Bacterial Toxins; D006460:Hemolysin Proteins; D012964:Sodium