[Morphohistochemical study of the rat placenta administered a hepatotropic poison at different periods of pregnancy].
Intragastric administration of CCl4 (0.3 ml per 100 g of body weight) to female rats caused a marked injury of the placental tissue and particularly of the chorionic epithelium of the labyrinthine portion with the maximal development of dystrophic necrobiotic processes on the 14th-16th day of pregnancy (when the poison was administered 48 hours before the animal was sacrificed). There was noted an increase in the number of mitoses in the epithelial cells at all the periods, and a statistically significant enlargement of the nuclei and the nucleoli of the cytotrophoblastic cells on the 17th--18th day of the intrauterine fetal development. CCl4 administration led to the reduction in the content of histochemically detectable glycogen in the cytoplasm of the chorionic epithelium and to the fall in the amount of amylase-resistant glycoproteins, protein and RNA in dystrophically altered cells.
D000818:Animals; D002251:Carbon Tetrachloride / Q000494:pharmacology*; D002455:Cell Division / Q000187:drug effects; D002466:Cell Nucleolus / Q000187:drug effects; D002467:Cell Nucleus / Q000187:drug effects; D002823:Chorion / Q000187:drug effects / Q000473:pathology; D005260:Female; D008938:Mitosis / Q000187:drug effects; D010920:Placenta / Q000187:drug effects* / Q000473:pathology; D011247:Pregnancy; D011270:Pregnancy, Animal / Q000187:drug effects*; D051381:Rats; D013997:Time Factors
D002251:Carbon Tetrachloride
Morfogistokhimicheskoe izuchenie platsenty krys pri vvedenii gepatotropnogo iada v razlichnye sriki beremennosti