The effect of minocycline, doxycycline and oxytetracycline on experimental mouse toxoplasmosis.
This is a comparative study of the effect of oral and parenteral administration of oxytetracycline, doxycycline and minocycline on experimental acute toxoplasmosis in mice. Two different inocula were used. All the antibiotics were ineffective orally. Doxycycline and minocycline were effective intraperitoneally, curing 90% of the mice who received the smaller inoculum. However, cerebral cysts of T. gondii were more common in the survivors treated with doxycycline.
D000284:Administration, Oral; D000818:Animals; D004195:Disease Models, Animal; D004318:Doxycycline / Q000008:administration & dosage / Q000627:therapeutic use*; D007274:Injections, Intraperitoneal; D008297:Male; D051379:Mice; D008911:Minocycline / Q000008:administration & dosage / Q000627:therapeutic use*; D010118:Oxytetracycline / Q000008:administration & dosage / Q000627:therapeutic use*; D013754:Tetracyclines / Q000627:therapeutic use*; D014124:Toxoplasmosis, Animal / Q000188:drug therapy*
D013754:Tetracyclines; D008911:Minocycline; D004318:Doxycycline; D010118:Oxytetracycline