title: Increase in membrane conductance and positive inotropic action of hemolysin produced by Vibrio parahaemolyticus on rabbit myocardium.
abstract: The effects of purified thermostable direct hemolysin from the cultured filtrate of Vibrio parahaemolyticus on both S-A node cells and atrial cells were studied electrophysiologically. Hemolysin caused the membrane conductance to increase, thereby causing membrane depolarization. The major ion responsible for this depolarization was Na+, but other ions, such as K+ and Ca2+, also participated. Positive inotropic action of hemolysin was observed, and the Na-Ca exchange mechanism was enhanced after hemolysin treatment.
mesh_terms: D000200:Action Potentials / Q000187:drug effects; D000818:Animals; D016275:Atrial Function; D001427:Bacterial Toxins / Q000494:pharmacology*; D006321:Heart / Q000187:drug effects / Q000502:physiology*; D006460:Hemolysin Proteins / Q000494:pharmacology*; D008564:Membrane Potentials / Q000187:drug effects; D009200:Myocardial Contraction / Q000187:drug effects*; D011817:Rabbits; D012849:Sinoatrial Node / Q000502:physiology; D012964:Sodium / Q000494:pharmacology; D014736:Vibrio parahaemolyticus
chemical_list: D001427:Bacterial Toxins; D006460:Hemolysin Proteins; D012964:Sodium