Dehydrodicaffeic acid dilactone, an inhibitor of catechol-O-methyl transferase.
In the screening of catechol-O-methyltransferase inhibitors, three compounds were isolated from the culture filtrate of a mushroom, Inonotus sp. One was 3,4-dihydroxycinnamic acid (caffeic acid) which had been reported as an inhibitor of this enzyme. The others were the dextrorotatory 2,6-bis-(3',4'-dihydroxyphenyl)-3,7-dioxabicyclo-[3,3,0]-octane 4,8-dione (dehydrodicaffeic acid dilactone) andits antipode. These new compounds inhibited both dopamine beta-hydroxylase and dopa decarboxylase and showed hypotensive activity in the SH rat.
D000818:Animals; D000970:Antineoplastic Agents; D065105:Aromatic Amino Acid Decarboxylase Inhibitors; D001487:Basidiomycota / Q000032:analysis; D001794:Blood Pressure / Q000187:drug effects; D002109:Caffeic Acids / Q000032:analysis / Q000302:isolation & purification / Q000494:pharmacology*; D065098:Catechol O-Methyltransferase Inhibitors; D002478:Cells, Cultured; D055598:Chemical Phenomena; D002621:Chemistry; D002934:Cinnamates / Q000494:pharmacology*; D003864:Depression, Chemical; D004299:Dopamine beta-Hydroxylase / Q000037:antagonists & inhibitors; D005260:Female; D066298:In Vitro Techniques; D007700:Kinetics; D008297:Male; D051381:Rats
D000970:Antineoplastic Agents; D065105:Aromatic Amino Acid Decarboxylase Inhibitors; D002109:Caffeic Acids; D065098:Catechol O-Methyltransferase Inhibitors; D002934:Cinnamates; D004299:Dopamine beta-Hydroxylase