title: Regulatory hyperparathyroidism: the role of C-cell hyperplasia.
abstract: Four cases with clinical and biochemical evidence of hyperparathyroidism are reported. The syndrome was due to DHT-intoxication of iatrogenic origin in the first case to histologically confirmed C-cell hyperplasia of the thyroid in the three others. The collective term "regulatory hyperparathyroidism" is porposed for the syndromes which, in distinction to secondary parathyroidisms, have a pathogenesis other than a negative calcium balance. Management of the syndrome is discussed with particular emphasis on the removal of the TCT-producing hyperplasia or adenoma, and the restoration of the electrolyte balance.
mesh_terms: D000368:Aged; D002116:Calcitonin / Q000097:blood; D005260:Female; D006801:Humans; D006934:Hypercalcemia / Q000150:complications / Q000378:metabolism; D006961:Hyperparathyroidism / Q000097:blood / Q000209:etiology / Q000473:pathology*; D006965:Hyperplasia; D008275:Magnesium Deficiency / Q000097:blood / Q000150:complications; D008297:Male; D008875:Middle Aged; D010281:Parathyroid Hormone / Q000097:blood; D013577:Syndrome; D013961:Thyroid Gland / Q000473:pathology*; D014807:Vitamin D / Q000378:metabolism
chemical_list: D010281:Parathyroid Hormone; D014807:Vitamin D; D002116:Calcitonin