title: Swine dysentery: protection of pigs by oral and parenteral immunisation with attenuated Treponema hyodysenteriae.
abstract: An attenuated strain of Treponema hyodysenteriae was used to immunise 18 pigs in three experiments. Live attenuated spirochaetes were dosed orally and injected intra-peritoneally, and killed spirochaetes were injected intramuscularly with adjuvant. The vaccinated pigs, which developed high serum agglutination titres against T hyodysenteriae, and 18 unvaccinated litter-mates were repeatedly challenged with virulent T hyodysenteriae. Nine vaccinated pigs and 16 control pigs developed typical swine dysentery.
mesh_terms: D000372:Agglutination Tests; D000818:Animals; D004403:Dysentery / Q000276:immunology / Q000662:veterinary*; D007114:Immunization / Q000662:veterinary*; D013552:Swine; D013553:Swine Diseases / Q000276:immunology / Q000517:prevention & control*; D014208:Treponema / Q000276:immunology*; D014211:Treponemal Infections / Q000276:immunology / Q000517:prevention & control / Q000662:veterinary*