[Carcinogenicity of N-nitroso compounds].
The toxic, carcinogenic and mutagenic effects of N-nitroso compounds are briefly discussed with reference to recent reviews. These adverse biological effects are discussed in relation to the necessity of metabolic activation by microsomal enzymes for the nitrosamins but not for the nitrosamides.
D000577:Amides / Q000378:metabolism / Q000633:toxicity; D000818:Animals; D002273:Carcinogens; D004938:Esophageal Neoplasms / Q000139:chemically induced; D005260:Female; D005770:Gastrointestinal Neoplasms / Q000139:chemically induced; D006801:Humans; D007680:Kidney Neoplasms / Q000139:chemically induced; D008113:Liver Neoplasms / Q000139:chemically induced; D008770:Methylnitrosourea / Q000378:metabolism / Q000633:toxicity; D008861:Microsomes / Q000201:enzymology; D009153:Mutagens; D009602:Nitrosamines / Q000633:toxicity; D009603:Nitroso Compounds / Q000378:metabolism / Q000633:toxicity*; D011247:Pregnancy; D011248:Pregnancy Complications; D012142:Respiratory Tract Neoplasms / Q000139:chemically induced; D013329:Structure-Activity Relationship; D013723:Teratogens
D000577:Amides; D002273:Carcinogens; D009153:Mutagens; D009602:Nitrosamines; D009603:Nitroso Compounds; D013723:Teratogens; D008770:Methylnitrosourea
Cancérogénicité des composés N-nitrosés.