title: [Activity of lactate dehydrogenase and its isoenzymes in the thrombocytes in different forms of cerebral circulatory disorder].
abstract: In thrombocytes of patients with ischemic and hemorrhagic insult a transformation in the isozyme spectrum of lactate dehydrogenase was observed without an alteration in the reaction rate. In this case LDH3 was decreased and LDH1 and LDH4 were increased. The correlation was not found between the type of insult and the character of the isozyme spectrum. The alterations were considered as an adaptive mechanism and the reflected the extent of immediate or intermediate effect of ischemia on thrombocytes.
mesh_terms: D000293:Adolescent; D000328:Adult; D001792:Blood Platelets / Q000201:enzymology*; D002543:Cerebral Hemorrhage / Q000175:diagnosis; D002561:Cerebrovascular Disorders / Q000175:diagnosis*; D004796:Clinical Enzyme Tests / Q000379:methods; D006406:Hematoma / Q000175:diagnosis; D006801:Humans; D002546:Ischemic Attack, Transient / Q000175:diagnosis; D007527:Isoenzymes; D007770:L-Lactate Dehydrogenase / Q000097:blood*; D008875:Middle Aged; D013345:Subarachnoid Hemorrhage / Q000175:diagnosis
chemical_list: D007527:Isoenzymes; D007770:L-Lactate Dehydrogenase
vernacular_title: Aktivnost' laktatdegidrogeazy i ee izofermenty v trombotsitakh pri razlichnykh formakh narusheniia mozgovogo krovoobrashcheniia