Polymer structure and blood compatibility evaluation - application of an acrylonitrile copolymer.
An acrylonitrile-dimethylaminoethyl methacrylate copolymer has been synthesised by a straightforward procedure. The cationic nature of the copolymer permits ready attachement of heparin and reaction of the copolymer with ethylene oxide gas allows a controlled alteration in chemical structure. These featues of the copolymer are discussed with respect to the influence of polymer properties on blood compatibility as exemplified by blood platelet retention.
D000180:Acrylic Resins / Q000633:toxicity*; D000181:Acrylonitrile / Q000031:analogs & derivatives / Q000633:toxicity*; D004347:Drug Interactions; D006493:Heparin / Q000494:pharmacology*; D006801:Humans; D009570:Nitriles / Q000633:toxicity*; D010973:Platelet Adhesiveness / Q000187:drug effects*; D011109:Polymethacrylic Acids / Q000138:chemical synthesis / Q000633:toxicity*
D000180:Acrylic Resins; D009570:Nitriles; D011109:Polymethacrylic Acids; D006493:Heparin; D000181:Acrylonitrile