[Lipid-mobilizing activity of a synthetic peptide identical to 33-44 fragment of human growth hormone].
The lipid-mobilizing activity of a synthetic peptide, NH2-Phe-Glu-Glu-Ala-Tyr-Ile-Pro-Lys-Glu-Gln-Lys-Tyr-Ser-Phe-COOH, corresponding to the 31-44 amino-acid sequence of human growth hormone, was studied. The peptide stimulated lypolysis upon administration to fasted rats and during incubation with isolated epidiymal adiposed tissue of rat and perirenal adiposed tissue of rabbit. The lipid-mobilizing effect of the peptide,unlike the corresponding effect of the native growth hormone, developed fast and was markedly pronounced 15-30 min after the incubation was started. Direct dependence between the peptide dose logarithm and the effect studied was observed at concentrations of 0.01-10microng/ml during incubation with rat adipose tissue and at 0.001-0.1 microng/ml during incubation with rabbit tissue.
D000273:Adipose Tissue / Q000378:metabolism*; D000818:Animals; D004305:Dose-Response Relationship, Drug; D005230:Fatty Acids, Nonesterified / Q000097:blood; D013006:Growth Hormone / Q000494:pharmacology*; D066298:In Vitro Techniques; D008053:Lipid Mobilization / Q000187:drug effects*; D010455:Peptides / Q000008:administration & dosage / Q000302:isolation & purification / Q000494:pharmacology*; D011817:Rabbits; D051381:Rats
D005230:Fatty Acids, Nonesterified; D010455:Peptides; D013006:Growth Hormone
Zhiromobilizuiushchaia aktivnost' sinteticheskogo peptida, identichnogo fragmentu 31-44 gormona rosta cheloveka