[Effect of caffeine on the content of the components of the adenyl system and on the activity of p32 incorporation into the myocardium of rats during early periods of their growth].
Caffeine sodium benzoate was injected intraperitoneally at one time in doses of 1 and 50 mg/100 g to rates aged 30 days and 3--5 months. The ATP, ADP, AMP, inorganic phosphorus levels and the p32 incorporation activity were determined in the myocardium. Introduction of the drug in a dose of 1 mg/100 g is shown not to produce any substantial shifts on the level of the study indices in 7-day old and adult animals and to increase the ATP content in 30-day old rattlings. Administration of caffeine in a dose of 50 mg/100 g brings down the ATP content in the myocardium of the animals in all the age categories. As regards the degree of the ATP level changes the 7-day old rattlings are more resistant than are the adult animals.
D000227:Adenine Nucleotides / Q000378:metabolism*; D000244:Adenosine Diphosphate / Q000032:analysis / Q000378:metabolism; D000249:Adenosine Monophosphate / Q000032:analysis / Q000378:metabolism; D000255:Adenosine Triphosphate / Q000032:analysis / Q000378:metabolism; D000375:Aging; D000818:Animals; D002110:Caffeine / Q000008:administration & dosage / Q000494:pharmacology*; D003124:Colorimetry; D004590:Electrophoresis, Paper; D007274:Injections, Intraperitoneal; D009206:Myocardium / Q000032:analysis / Q000378:metabolism*; D010758:Phosphorus / Q000032:analysis / Q000378:metabolism; D010761:Phosphorus Radioisotopes; D051381:Rats; D013053:Spectrophotometry
D000227:Adenine Nucleotides; D010761:Phosphorus Radioisotopes; D010758:Phosphorus; D002110:Caffeine; D000249:Adenosine Monophosphate; D000244:Adenosine Diphosphate; D000255:Adenosine Triphosphate
Vliianie kofeina na soderzhanie komponentov adenilovoĭ sistemy i aktivnost' vkliucheniia p32 v myshtsu serdtsa krys v rannye periody rosta organizma