Serum glycoproteins level and urinary glycosaminoglycans excretion in drug induced collagen-like syndrome in guinea pigs.
A collagen-like syndrome was produced by a long-term administration of 1-hydrazinophthalazine (hydralazine) to guinea pigs. The results obtained indicate that hydralazine-induced collagen-like syndrome stimulated an increase of the concentration of perchloric acid-soluble proteins, protein-bound hexoses, protein-bound-hexosamines and sialic acids in blood serum as well as urinary excretion of glycosaminoglycans. The increase of serum glycoproteins is not connected with non-specific changes in total protein level. No biochemical differences were found in the parameters studied between subgroups (LE-positive and LE-negative) of hydralazine treated animals.
D000818:Animals; D003095:Collagen Diseases / Q000139:chemically induced / Q000378:metabolism*; D004195:Disease Models, Animal; D006023:Glycoproteins / Q000097:blood*; D006025:Glycosaminoglycans / Q000652:urine*; D006168:Guinea Pigs; D006830:Hydralazine; D008297:Male; D013577:Syndrome
D006023:Glycoproteins; D006025:Glycosaminoglycans; D006830:Hydralazine