Porcine pituitary peptides with opiate-like activity: partial purification and effects in the rat after intraventricular injection.
A peptide material with opiate-like activity in the guinea-pig ileum was extracted from porcine pituitaries using a hot glacial acetic acid extraction method and was partially purified by gel filtration. When injected intraventricularly in rats, these purified peptides induced strong analgesia, catelepsy, respiratory depression and other opiate-like effects, which lasted for several hours.
D000698:Analgesia; D000818:Animals; D002375:Catalepsy / Q000139:chemically induced; D006801:Humans; D009270:Naloxone; D009294:Narcotics; D010455:Peptides / Q000302:isolation & purification / Q000494:pharmacology*; D010902:Pituitary Gland / Q000032:analysis; D051381:Rats; D012119:Respiration / Q000187:drug effects; D013552:Swine; D014020:Tissue Extracts / Q000494:pharmacology
D009294:Narcotics; D010455:Peptides; D014020:Tissue Extracts; D009270:Naloxone