title: Synthesis of 1.4-naphthoquinones-4-aryl(aroyl)hydrazones of potential antimicrobial activity.
abstract: The isolation of phthiocol (3-hydroxy-2-methyl-1.4-naphthoquinone) from the acetone-soluble fat fraction of tubercle bacilli [1, 2] and the confirmation that it had antituberculous activity against H-37 R.V. strain [20] in vitro and in mice [12], prompted the synthesis of some 2-alkyl-3-hydroxy-1.4-naphthoquinone-4-aryl(aroyl)hydrazones as possible tuberculostatic agents.
mesh_terms: D000890:Anti-Infective Agents / Q000138:chemical synthesis*; D055598:Chemical Phenomena; D002621:Chemistry; D006834:Hydrazines; D006835:Hydrazones / Q000138:chemical synthesis*; D008722:Methods; D009285:Naphthoquinones / Q000138:chemical synthesis*
chemical_list: D000890:Anti-Infective Agents; D006834:Hydrazines; D006835:Hydrazones; D009285:Naphthoquinones