[Influence of the functional state of the endocrine glands on the toxicity and accumulation of lithium in rats].
Hypophysectomy, adrenalectomy, introduction of desoxycorticosterone-acetate (DOCCA) and aldosterone facilitate cummulation of lithium in the organs and plasma of rats subjected to the action of lithium chloride, whereas thyroidectomy, administration of triiodothyronine, hydrocortisone and aldactone fail to influence this process. The toxicity of lithium chloride for animals increases with hypophysectomy and adrenalectomy, remains unchanged with introduction of DOCCA, triiodothyronine and thyroidectomy and subsides under the effect of hydrocortisone.
D000315:Adrenalectomy; D000450:Aldosterone / Q000494:pharmacology; D000818:Animals; D003900:Desoxycorticosterone / Q000494:pharmacology; D004702:Endocrine Glands / Q000503:physiopathology*; D005260:Female; D006854:Hydrocortisone / Q000494:pharmacology; D007016:Hypophysectomy; D008094:Lithium / Q000037:antagonists & inhibitors / Q000378:metabolism / Q000633:toxicity*; D008297:Male; D011817:Rabbits; D051381:Rats; D013965:Thyroidectomy; D014284:Triiodothyronine / Q000494:pharmacology
D014284:Triiodothyronine; D003900:Desoxycorticosterone; D000450:Aldosterone; D008094:Lithium; D006854:Hydrocortisone
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