[Extent and duration of drug-induced stimulation of renal excretion of p-aminohippuric acid].
Repeated pretreatment with p-aminohippuric acid (PAH), probenecide, cyclopenthiazide, and phenobarbital stimulates the renal excretion of PAH. For an interval of at least 6 hrs following i.p. application pretreated rats excrete more PAH excretion than the controls. All the drugs studied were found to stimulate renal PAH excretion within a period of 3 hrs by 50-60% of the control value. The required duration of pretreatment varies with the substance used. With cyclopenthiazide, the excretion of PAH is demonstrable for 2-3 weeks. Phenobarbital has a brief stimulating action. Correlations of a binding of drugs to structures of their tubular cell and the length of the stimulating action are discussed.
D000618:Aminohippuric Acids / Q000494:pharmacology*; D000818:Animals; D003518:Cyclopenthiazide / Q000494:pharmacology; D005260:Female; D005919:Glomerular Filtration Rate / Q000187:drug effects; D007668:Kidney / Q000187:drug effects*; D010634:Phenobarbital / Q000494:pharmacology; D011292:Premedication; D011339:Probenecid / Q000494:pharmacology; D051381:Rats; D013268:Stimulation, Chemical; D013997:Time Factors; D010130:p-Aminohippuric Acid / Q000494:pharmacology* / Q000652:urine
D000618:Aminohippuric Acids; D011339:Probenecid; D003518:Cyclopenthiazide; D010130:p-Aminohippuric Acid; D010634:Phenobarbital
Ausmass und Dauer der Stimulation der renalen Ausscheidung von p-Aminohippursäure durch Pharmaka