Cerebral blood flow under enflurane anesthesia.
Cerebral blood flow was measured, under controlled conditions of stable ventilation and PaCO2, in 11 patients suffering from cerebro-vascular lesions. Comparing the results under N2O-enflurane 1% anesthesia with those under N2O-fentanyl anesthesia shows an average 8.4% decrease of blood flow. In 5 cases, a third measurement was performed under N2O-enflurane 2% anesthesia. This caused an average 8.5% complementary decrease. Whereas most inhalational anesthetic agents produce an increase of cerebral blood flow, this is not observed with enflurane, the tendency rather being towards a decrease.
D000328:Adult; D000368:Aged; D002560:Cerebrovascular Circulation / Q000187:drug effects*; D002561:Cerebrovascular Disorders / Q000503:physiopathology; D004737:Enflurane / Q000494:pharmacology*; D006221:Halothane / Q000494:pharmacology; D006801:Humans; D008738:Methyl Ethers / Q000494:pharmacology*; D008875:Middle Aged
D008738:Methyl Ethers; D004737:Enflurane; D006221:Halothane