title: Effect of immunosuppressive therapy on the serum glycoprotein levels in chronic aggressive hepatitis.
abstract: The sera of 24 patients with chronic aggressive hepatitis receiving combined immunosuppressive therapy were studied for the concentrations of the carbohydrate components of glycoproteins and the IgG, IgA, IgM, alpha-2-macroglobulin, coeruloplasmin, beta-1-C-globulin and transferrin levels over a period of 2 years. Liver biopsy was performed repeatedly in 50% of the cases. On the evidence of the results, combined immunosuppressive treatment is regarded as apt to normalize the serum concentrations of IgG, IgA, IgM and to reduce those of alpha-2-macroglobulin and coeruloplasmin. Among the carbohydrate components of glycoproteins only the amount of hexose was reduced.
mesh_terms: D000328:Adult; D001379:Azathioprine / Q000494:pharmacology / Q000627:therapeutic use; D002241:Carbohydrates / Q000097:blood; D002570:Ceruloplasmin / Q000378:metabolism; D006023:Glycoproteins / Q000097:blood*; D006505:Hepatitis / Q000097:blood* / Q000188:drug therapy; D006601:Hexoses / Q000097:blood; D006801:Humans; D007070:Immunoglobulin A / Q000378:metabolism; D007074:Immunoglobulin G / Q000378:metabolism; D007075:Immunoglobulin M / Q000378:metabolism; D007166:Immunosuppressive Agents / Q000494:pharmacology / Q000627:therapeutic use*; D008297:Male; D011239:Prednisolone / Q000494:pharmacology / Q000627:therapeutic use; D012712:Serum Globulins / Q000378:metabolism; D014168:Transferrin / Q000378:metabolism
chemical_list: D002241:Carbohydrates; D006023:Glycoproteins; D006601:Hexoses; D007070:Immunoglobulin A; D007074:Immunoglobulin G; D007075:Immunoglobulin M; D007166:Immunosuppressive Agents; D012712:Serum Globulins; D014168:Transferrin; D011239:Prednisolone; D002570:Ceruloplasmin; D001379:Azathioprine