"Pseudo-giant P-waves" and pericardial friction rub following chlorpromazine therapy.
A patient is presented who manifested two previously undescribed complications of chlorpromazine therapy: a transient pericardial friction rub and "pseudo-giant P waves". After slowing of the heart rate, the "giant P-waves" proved to be superimposed U and P-waves. His history demonstrates the protean and at times unusual complications of chlorpromazine therapy and illustrates the dramatic therapeutic effects diphenhydramine may have in reversing some of this toxicity.
D000328:Adult; D002746:Chlorpromazine / Q000009:adverse effects*; D004562:Electrocardiography; D006326:Heart Auscultation; D006339:Heart Rate / Q000187:drug effects*; D006347:Heart Sounds; D006801:Humans; D008297:Male
D002746:Chlorpromazine