Influence of albumin degradation products (ADP) on the central action of catecholamines.
The influence of ADP on the central action of catecholamines was investigated. ADP abolished the central action of noradrenaline, amphetamine and nialamide. The peptides decreased apomorphine stereotypy and enhanced haloperidol induced catalepsy. These results support our previous suggestions [10-14] that ADP acts on the CNS by antagonizing the action of central catecholamines.
D000418:Albumins / Q000494:pharmacology*; D000661:Amphetamine / Q000037:antagonists & inhibitors; D000818:Animals; D001058:Apomorphine / Q000494:pharmacology; D001679:Biogenic Amines / Q000378:metabolism; D001921:Brain / Q000187:drug effects* / Q000378:metabolism; D002375:Catalepsy / Q000139:chemically induced; D002395:Catecholamines / Q000494:pharmacology*; D004347:Drug Interactions; D006220:Haloperidol / Q000494:pharmacology; D006801:Humans; D008297:Male; D009043:Motor Activity / Q000187:drug effects; D009526:Nialamide / Q000494:pharmacology; D009638:Norepinephrine / Q000494:pharmacology; D010455:Peptides / Q000494:pharmacology; D051381:Rats; D013997:Time Factors
D000418:Albumins; D001679:Biogenic Amines; D002395:Catecholamines; D010455:Peptides; D000661:Amphetamine; D006220:Haloperidol; D001058:Apomorphine; D009526:Nialamide; D009638:Norepinephrine