[Importance of bile for stress ulcer in the rat].
The influence of bile on ulcer formation under restraint stress condition was studied in rats. Animals with a choledochogastrostomy or a pyloroplasty showed as many ulcers as the sham-operated controls. After choledochoileostomy or bile duct ligation the ulcer frequency was reduced by half. A pharmacologic binding of the bile salts by intragastral cholestyramine had the same effect.
D000818:Animals; D001646:Bile / Q000378:metabolism*; D001647:Bile Acids and Salts / Q000378:metabolism; D002792:Cholestyramine Resin / Q000627:therapeutic use; D004195:Disease Models, Animal; D008026:Ligation; D008297:Male; D010437:Peptic Ulcer / Q000188:drug therapy / Q000209:etiology / Q000378:metabolism*; D051381:Rats; D013312:Stress, Physiological / Q000378:metabolism*
D001647:Bile Acids and Salts; D002792:Cholestyramine Resin
Uber die Bedeutung der Galle für das Stressulcus der Ratte.