Etiologic related studies of ultraviolet light-mediated carcinogenesis.
Comparisons were made of cholesterol-5alpha, 6alpha-epoxide (CAE) levels in skin of hairless mice maintained on a regular or antioxidant supplemented diet and receiving chronic ultraviolet light (UVL) radiation over an 18-week period. Cholesterol-5alpha, 6alpha-epoxide levels in skin of animals on antioxidant supplemented diet, while reaching a peak four weeks after that of animals on regular diet, thereafter were consistently higher. Dietary antioxidants nevertheless had an inhibitory effect on UVL-induced tumors. These data are inconsistent with the theory of CAE involvement as an ultimate carcinogen in UVL-mediated carcinogenesis.
D000818:Animals; D000975:Antioxidants / Q000494:pharmacology; D002273:Carcinogens; D002784:Cholesterol / Q000031:analogs & derivatives / Q000032:analysis / Q000378:metabolism*; D005260:Female; D051379:Mice; D008819:Mice, Nude; D009374:Neoplasms, Experimental / Q000032:analysis / Q000209:etiology; D009381:Neoplasms, Radiation-Induced / Q000032:analysis; D010777:Photochemistry; D012867:Skin / Q000032:analysis / Q000528:radiation effects; D012878:Skin Neoplasms / Q000032:analysis / Q000209:etiology*; D013997:Time Factors; D014466:Ultraviolet Rays
D000975:Antioxidants; D002273:Carcinogens; D002784:Cholesterol