title: [Sporadic adult hypophosphatemic vitamin D resistant osteomalacia (phosphate diabetes) and hyperparathyroidism].
abstract: Report on a patient with osteomalacia due to renal phosphate loss. At onset the patient was aged 43 years. No other tubular defects were detected except glycinuria. The patient was followed over a period of 12 years. 3 years after treatment with oral phosphate and vitamin D3 persistent hypercalcemia developed with highly elevated levels of parathyroid hormone. After removal of one enlarged parathyroid gland serum calcium normalized, but elevated parathyroid hormone levels still persist. The spontaneous occurrence of hypophosphatemic osteomalacia in an adult male and its connections with the development of hyperparathyroidism are discussed.
mesh_terms: D000328:Adult; D001827:Body Height; D001991:Bronchitis / Q000188:drug therapy; D004646:Emphysema / Q000209:etiology; D006801:Humans; D006934:Hypercalcemia / Q000139:chemically induced; D006961:Hyperparathyroidism / Q000209:etiology*; D007545:Isoproterenol; D008297:Male; D008875:Middle Aged; D010018:Osteomalacia / Q000150:complications*; D010280:Parathyroid Glands / Q000601:surgery; D010710:Phosphates / Q000627:therapeutic use; D011241:Prednisone / Q000627:therapeutic use; D013806:Theophylline / Q000627:therapeutic use; D014807:Vitamin D / Q000627:therapeutic use
chemical_list: D010710:Phosphates; D014807:Vitamin D; D013806:Theophylline; D007545:Isoproterenol; D011241:Prednisone
vernacular_title: Sporadische hypophosphatämische vitamin-D-resistente Osteomalazie (Phosphatdiabetes) im Erwachsenenalter und Hyperparathyroidismus