A second method for induction of a transmissible entity in the control of cancer in mice.
Spontaneous tumour-bearing mice of the C3H/St and subline C3HB/St inbred strains received injections of three nucleosides, adenosine, 6-methyl adenosine, and 5-methyl cytidine, prepared in the same molecular concentration as they had occurred in an alcohol-soluble liver extract which in previous work had suppressed tumour growth. Two transmissible entities appear to be present and they show different degrees of effect upon the growth and regression of spontaneous tumours of mammary gland origin (adenocarcinoma). The first transmissible entity (TE) occurred in the lineal descent of mice following injection of the liver extract. The second entity (TE2) appeared following injection of 5-methyl cytidine. TE manifested its maximum effect in suppressing cancer in mice during the 20th generation of a lineal descent following the injection of the original liver extract into a mother of the cancer proband. TE2 appears to be optimal in controlling cancer in the F11 generation of a second lineal descent derived from an original cancer proband of the C3H/St inbred strain injected with 5-methyl cytidine.
D000230:Adenocarcinoma / Q000188:drug therapy* / Q000235:genetics; D000241:Adenosine / Q000031:analogs & derivatives / Q000627:therapeutic use; D000818:Animals; D003562:Cytidine / Q000031:analogs & derivatives* / Q000627:therapeutic use; D008099:Liver / Q000502:physiology*; D008325:Mammary Neoplasms, Experimental / Q000188:drug therapy* / Q000235:genetics; D051379:Mice; D008809:Mice, Inbred C3H
D003562:Cytidine; D000241:Adenosine