Derivatives of 3-p-chlorophenyl-3-oxopropane and 3-p-chlorophenyl-3-hydroxypropane-1-carboxylic acids.
Starting from gamma-chlorophenyltetrahydro- and gamma-chlorophenyldihydro-furan-2-ones (2 and 12), some new amides and hydrazides of the acids mentioned in the title were prepared (Table 1 and 2). Of the obtained compounds the following 10, 14, 15, 17, 20--23 show central depressant action.
D000577:Amides; D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects; D002087:Butyrates / Q000138:chemical synthesis / Q000494:pharmacology / Q000633:toxicity; D003864:Depression, Chemical; D006834:Hydrazines; D006885:Hydroxybutyrates / Q000138:chemical synthesis* / Q000494:pharmacology / Q000633:toxicity; D007651:Keto Acids / Q000138:chemical synthesis* / Q000494:pharmacology / Q000633:toxicity; D007928:Lethal Dose 50; D051379:Mice
D000577:Amides; D002087:Butyrates; D006834:Hydrazines; D006885:Hydroxybutyrates; D007651:Keto Acids