title: In vitro elastic fiber formation by aggregated arotic cells of newborn rabbits.
abstract: Cells isolated enzymatically from the aortas of newborn rabbits were aggregated and grown in organ culture. Bundles of microfibrils, some of them with an amouphous core (elastin), were evident in 3-day-old aggregates. Furthermore, droplets of elastin surrounded by darker dots and short filaments, corresponding to the elastic units were observed. In 6-day-old aggregates the number of elastic fibers composed of bundles of microfibrils with deposited elastin increased. Elastic elements which probably resulted from a coalescence of elastic units were also present. These two ways of elastic fiber formation in aggregates are compared with those described in papers on aortic development.
mesh_terms: D000818:Animals; D001011:Aorta / Q000648:ultrastructure*; D002449:Cell Aggregation; D002478:Cells, Cultured; D004547:Elastic Tissue / Q000648:ultrastructure*; D004549:Elastin; D011817:Rabbits; D013997:Time Factors
chemical_list: D004549:Elastin