[Effects of intraluminal pressure increase on oxygen consumption of the rabbit ileum and its possible pharmacological modification].
Elevated intraluminal pressure of rabbit small bowel induces a decrease of tissue pO2 of the bowel wall dependent on the applied pressure. After decompression local pO2 exceeds the initial pO2 values. While the i.v. application of 25 microgram/kg glucagon is not able to improve local oxygen supply of the distended bowel, local pO2 increases considerably after infusion of 7.5 ml/kg dextran 40. Decompression by operation or intestinal tube as well as application of dextran 40 are recommended in the treatment of ileus.
D000818:Animals; D003911:Dextrans / Q000494:pharmacology / Q000627:therapeutic use; D005260:Female; D005934:Glucagon / Q000494:pharmacology / Q000627:therapeutic use; D007082:Ileum / Q000503:physiopathology*; D007415:Intestinal Obstruction / Q000188:drug therapy / Q000503:physiopathology; D008297:Male; D010100:Oxygen / Q000097:blood; D010101:Oxygen Consumption / Q000187:drug effects*; D010313:Partial Pressure; D011817:Rabbits
D003911:Dextrans; D005934:Glucagon; D010100:Oxygen
Auswirkungen der intraluminären Druckerhöhung auf die Sauerstoffversorgung des Kaninchenileums und ihre pharmakologische Beeinflussbarkeit.