[Fructose-1,6-diphosphate aldolase and ketose-1-phosphate aldolase isoenzyme spectra in the kidneys normally and in uranyl acetate poisoning].
Activities of both aldolases were distinctly decreased in acute kidney insufficiency, caused by administration of uranyl acetate. The decrease in the activity of fructose-1,6-diphosptate aldolase was more distinct which led to alteration in ratio between fructose -1,6-diphosphate and ketose-1-phosphate aldolases. The isozyme spectra of the enzymes were also altered. Isozymes of fructose-1,6-diphosphate aldolase AB2 and of ketose-1-phosphate aldolase form 22 possessed the same electrophoretic mobility but their relative activity was increased 2-3-fold under conditions of the acute kidney insufficiency. At the same time, the more electrophoretically mobile isozymes were not detected.
D000085:Acetates / Q000506:poisoning; D000208:Acute Disease; D000446:Aldehyde-Lyases / Q000378:metabolism*; D000818:Animals; D004789:Enzyme Activation / Q000187:drug effects; D005634:Fructose-Bisphosphate Aldolase / Q000378:metabolism*; D007527:Isoenzymes / Q000378:metabolism*; D007668:Kidney / Q000201:enzymology*; D007684:Kidney Tubules / Q000201:enzymology; D008297:Male; D011041:Poisoning / Q000201:enzymology; D051381:Rats; D013997:Time Factors; D014501:Uranium / Q000506:poisoning*
D000085:Acetates; D007527:Isoenzymes; D014501:Uranium; D000446:Aldehyde-Lyases; D005634:Fructose-Bisphosphate Aldolase
Izofermentnye spektry fruktozo-1,6-difosfatal'dolazy i ketozo-1-fosfatal'dolazy v pochkakh v norme i pri otravlenii uranilatsetatom