[Manometry, effect of pentagastrin and appearance of reflux in experimentally created hiatal hernia (author's transl)].
The importance of morphological and hormonal factors in the gastro-oesophageal junction can be evaluated, since a hiatal hernia comparable to the axial sliding hernia could be created in animal experiments. A new adequate procedure of manometry enables intraluminal pressures to be measured as a functional analysis. In 10 dogs a hiatal hernia with roentgenological reflux was performed. Pentagastrin administered intravenously could not prevent the gastro-oesophageal reflux. Pentagastrin intensified the muscle tension for only 5 minutes, but could not maintain the closing mechanism because of the altered morphological structure. After having restored the longitudinal tension of the organ by gastropexia, the terminal oesophagus has regained its closing function.
D000818:Animals; D004195:Disease Models, Animal; D004285:Dogs; D004943:Esophagogastric Junction / Q000187:drug effects; D005764:Gastroesophageal Reflux / Q000503:physiopathology; D006548:Hernia, Diaphragmatic / Q000503:physiopathology*; D006551:Hernia, Hiatal / Q000150:complications / Q000503:physiopathology*; D006801:Humans; D008365:Manometry / Q000379:methods*; D010418:Pentagastrin / Q000008:administration & dosage / Q000494:pharmacology*; D013268:Stimulation, Chemical
D010418:Pentagastrin
Druckmessung, Pentagastrinwirkung und Refluxverhalten bei der experimentell gesetzten Hiatushernie