Cellular patterns in the early phase of healing wounds in children.
Cellular patterns of the healing incisional wound were studied in 55 pediatric surgical patients by the CELLSTIC method. This wound drain, specially developed for this purpose, consists af a standard-sized, viscose cellulose sponge, inside a thin silicone rubber tube. When left between the wound edges, wound exudate flows outwards through the drain, allowing its cells to attach to the sponge surface. The sponge serves as a framework where the cells may migrate, divide and transform. During the first 12 hours the cellular pattern in the sponge resembles that of peripheral blood, whereafter the number of polymorphonuclear leukocytes, almost exclusively neutrophils, gradually increases. Later on lymphocytes and monocytes invade. The first fibroblasts were seen at the end of the third postoperative day.
D002455:Cell Division; D002648:Child; D002675:Child, Preschool; D005260:Female; D005347:Fibroblasts / Q000473:pathology; D006097:Granulation Tissue / Q000473:pathology*; D006801:Humans; D007962:Leukocytes / Q000473:pathology; D008214:Lymphocytes / Q000473:pathology; D008297:Male; D008938:Mitosis; D009000:Monocytes / Q000473:pathology; D009504:Neutrophils / Q000473:pathology; D013997:Time Factors; D014945:Wound Healing