[DNA inhibition and development of the pigment epithelium and receptors in rat retina].
In the retina of the guinea pig the outer segments of the receptor cells are damaged by cyclophosphamid, but the inner segments and the centriole are not altered. The disturbed membranes of the outer segments are incorporated by pigment epithelium. The progress of degeneration of outer segments corresponds with the increase of the number of Lysosomes in the pigmemt epithelium. The structure of mitochondria is disturbed by blocking the DNA. The unaltered mitochondria show a normal reaction of succinode hydrogenase.
D000818:Animals; D000831:Animals, Newborn; D003520:Cyclophosphamide / Q000494:pharmacology; D004247:DNA / Q000096:biosynthesis*; D010786:Photoreceptor Cells / Q000187:drug effects / Q000378:metabolism / Q000648:ultrastructure*; D010857:Pigment Epithelium of Eye / Q000187:drug effects / Q000378:metabolism / Q000648:ultrastructure*; D051381:Rats; D012160:Retina / Q000187:drug effects / Q000648:ultrastructure*
D003520:Cyclophosphamide; D004247:DNA
DNA-Hemmung und Entwicklung des Pigmentepithels und der Rezeptoren der Retina der Ratte