[Morphology of the ovaries in congenital virilization of the external genitalia in persons with genetic and gonadal female sex].
A study was made of the resected ovarian tissue in 7 patients with congenital virilization of the external genitalia (CVEG). In patients with CVEG there occurred not very pronounced changes in the ovaries seen in diencephalic syndromes with the involvement of the ovaries into the pathological process (hypertrophy of the theca interna cells of the cystically changed follicles, hyperplasia of the intestinal tissue of the cortical layer with the transformation of individual cells into epithelioid, etc.). There were clinical signs indicating an acceleration of maturation of the diencephalic structures (some tendency to the acceleration of sexual development, and distinct signs of diencephalic pathology on the EEG). A conclusion was drawn that in the patients with CVEG the ovaries do not serve as the source of andronization of the organism. It is supposed that in these patients the source of hyperandronization existed at the period of formation of the external genitalia of the fetus and that the adrenal cortex of the fetus could serve as this source.
D000293:Adolescent; D000328:Adult; D002648:Child; D002675:Child, Preschool; D012734:Disorders of Sex Development / Q000235:genetics / Q000473:pathology*; D005260:Female; D006801:Humans; D008297:Male; D010053:Ovary / Q000473:pathology*; D012728:Sex Chromatin / Q000032:analysis; D012732:Sex Determination Analysis; D014770:Virilism / Q000151:congenital* / Q000235:genetics / Q000473:pathology
Morfologiia iaichnikov pri vrozhdennoĭ virilizatsii naruzhnykh genitaliĭ u lits s geneticheskim i gonadnym zhenskim polom