[In vitro incorporation of labelled amino acids into heart muscle ribosomes at early and late stages of compensatory heart hyperfunction].
The activity of a protein-synthesizing cell-free system from heart muscle was studied at early and late stages of compensatory heart hyperfunction. It was found that the incorporation of amino acids into heart ribosomes during 48 hours after the hyperfunction had been produced, increased by 30% as compared to the control. The incorporation of amino acids into heart ribosomes at the late stage of hyperfunction (after 6 months) was decreased by 46% as compared to the early stages. The addition of homologous tRNA to the cell-free system of protein synthesis under prolonged heart hyperfunction stimulated the incorporation of amino acids into the ribosomes by 40--50%.
D000596:Amino Acids / Q000378:metabolism; D000818:Animals; D002474:Cell-Free System; D006331:Heart Diseases / Q000378:metabolism*; D006339:Heart Rate; D008297:Male; D009124:Muscle Proteins / Q000096:biosynthesis*; D009206:Myocardium / Q000166:cytology / Q000378:metabolism*; D012343:RNA, Transfer / Q000494:pharmacology; D051381:Rats; D012269:Ribosomal Proteins / Q000096:biosynthesis*; D012270:Ribosomes / Q000187:drug effects / Q000378:metabolism; D013997:Time Factors
D000596:Amino Acids; D009124:Muscle Proteins; D012269:Ribosomal Proteins; D012343:RNA, Transfer
Vkliuhnie in vitro mechenykh aminokislot v pibosomy cerdechnoĭ myshtsy na pannei i pozdneĭ stadiiakh kompensatornoĭ giperfunktsii serdtsa