title: A genetic study on deaf twins.
abstract: A clinical and genetic study on 25 twin pairs with at least one deaf member was performed. Concordance rate of hearing loss was 0.88 in MZ and 0.50 in DZ pairs, with an almost complete penetrance (P = 0.94). Consanguinity was found in 32% of cases, corresponding to five times the average population rate in Japan.
mesh_terms: D000293:Adolescent; D000328:Adult; D003241:Consanguinity; D003638:Deafness / Q000151:congenital / Q000235:genetics*; D004200:Diseases in Twins; D005260:Female; D007839:Functional Laterality; D006801:Humans; D011247:Pregnancy; D014429:Twins, Dizygotic; D014430:Twins, Monozygotic