[Characteristics of chemical structure of analogs of the antimalarial drug chloridine (pyrimethamine), detetermining their teratogenic properties].
On an example of substituted 2,4-diaminopyrimidines containing at the 6th position hydrogen, alkyl radicals with a varying length of chains, ramified isoalkyl radicals and aromatic nuclei it is shown that the teratogenous activity is inherent only in some agents, being related to the chemical structure and conformation of the molecules. Accordingly, the principles of elective toxicity lying at the root of current chemotherapy may be extended also to teratology. From this it follows that there exists as a matter of principle the possibility of a purposeful synthesis of new medical compounds that would be devoid of teratogenous activity, but were endowed with valuable curative properties.
D000014:Abnormalities, Drug-Induced; D000818:Animals; D004622:Embryo, Mammalian / Q000187:drug effects; D005260:Female; D005313:Fetal Death / Q000139:chemically induced; D006859:Hydrogen / Q000032:analysis; D008956:Models, Chemical; D008968:Molecular Conformation; D011247:Pregnancy; D011739:Pyrimethamine / Q000009:adverse effects / Q000031:analogs & derivatives* / Q000032:analysis; D051381:Rats; D013329:Structure-Activity Relationship; D013723:Teratogens / Q000009:adverse effects / Q000032:analysis*
D013723:Teratogens; D006859:Hydrogen; D011739:Pyrimethamine
Osobennosti khimicheskogo stroeniia analogov antimaliariĭnogo preparata khloridina (primetamina), opredeliaiushchie ikh teratogennye svoĭstva