Pharmacological aspects of pyrazoline derivatives from 2-hydroxy-butenolides.
A series of pyrazoline derivatives was synthetised and evaluated for toxicological and pharmacological effects; analgesic, hypnotic, anti-inflammatory, antipyretic and cardiovascular properties were screened. Tested compounds were found to have a low toxicity; one of them showed a good analgesic activity without side effects.
D000700:Analgesics / Q000138:chemical synthesis / Q000633:toxicity; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000138:chemical synthesis / Q000633:toxicity; D001794:Blood Pressure / Q000187:drug effects; D004285:Dogs; D005260:Female; D006993:Hypnotics and Sedatives / Q000138:chemical synthesis / Q000633:toxicity; D007783:Lactones; D007928:Lethal Dose 50; D008297:Male; D051379:Mice; D009200:Myocardial Contraction / Q000187:drug effects; D011720:Pyrazoles / Q000138:chemical synthesis / Q000494:pharmacology* / Q000633:toxicity; D051381:Rats
D000700:Analgesics; D000893:Anti-Inflammatory Agents; D006993:Hypnotics and Sedatives; D007783:Lactones; D011720:Pyrazoles