title: Ocular development and involution in the European cave salamander, Proteus anguinus laurenti.
abstract: The anatomy and development of the eye of Proteus anguinus are described. The relationships between organogenesis of the eye in embryos and larva and its involution in the young and the adult are discussed. The availability (in breeding cultures) of a significant number of Proteus embryos (which are normally rare) allowed experimental analysis of the effects of light, xenoplastic differentiation and thyroid hormones on the development of the eye. The results of this study suggest that development and involution of the eye of Proteus are controlled by genetic factors which are not greatly influenced by environment, and one can, therefore, consider the microphthalmy of Proteus as a relict characteristic which is the result of a specific development with disturbance of the normal ontogenic process.
mesh_terms: D000367:Age Factors; D000818:Animals; D001921:Brain / Q000033:anatomy & histology; D003315:Cornea / Q000166:cytology; D004627:Embryonic Induction; D004777:Environment; D005123:Eye / Q000196:embryology / Q000254:growth & development* / Q000637:transplantation; D007814:Larva; D007908:Lens, Crystalline / Q000254:growth & development; D008027:Light; D024510:Muscle Development; D009132:Muscles / Q000033:anatomy & histology; D009801:Oculomotor Muscles / Q000254:growth & development; D012160:Retina / Q000254:growth & development; D012886:Skull / Q000033:anatomy & histology / Q000254:growth & development; D013974:Thyroxine / Q000494:pharmacology; D014183:Transplantation, Heterologous; D014562:Caudata / Q000033:anatomy & histology / Q000196:embryology / Q000254:growth & development*; D014795:Visual Pathways / Q000166:cytology
chemical_list: D013974:Thyroxine