The development of rabbit diploid cell lines.
The authors describe briefly studies on the development of diploid cell lines from fetal tissues (origin: four inbred rabbits). Some lines have been maintained in continuous serial culture for over three years. The Lung 16 may represent a qualifying rabbit diploid cell line when used between cell passages 48 and 100; during this period it has shown a minimum deviation from the normal diploid rabbit karyotype; it supports the growth of rubella virus, is non-tumorigenic and might be useful as a substrate for human vaccine.
D000818:Animals; D002460:Cell Line; D002869:Chromosome Aberrations; D004171:Diploidy; D007621:Karyotyping; D011123:Polyploidy; D011817:Rabbits; D011820:Rabies virus / Q000254:growth & development; D012412:Rubella virus / Q000254:growth & development; D014776:Virus Cultivation