[Reactions of hereophilic agglutinins with L-cells and different toxicity of anti-A HP to fibroblasts and L-cells in vitro].
The carbohydrate binding glycoprotein Anti-AHP binds to the plasma membrane of the (transformed) L-cell both in agglutination reactions and by the immunofluorescence technique. On the surface of (normal) mouse embryo fibroblast cells Anti-AHP receptors were not detectable. Anti-AHP is suitable as another marker for L cells. The random distribution of the binding sites at 4 degrees C changes with elevated temperatures (clustering, capping of sites). Anti-AHP inhibits the growth of L cells much more than that of fibroblasts. It does not act as a mitogen for the investigated cells.
D000372:Agglutination Tests; D000373:Agglutinins; D000818:Animals; D000910:Antibodies, Heterophile; D000917:Antibody Formation; D005347:Fibroblasts / Q000276:immunology*; D006023:Glycoproteins / Q000276:immunology; D006372:Helix, Snails / Q000276:immunology*; D007739:L Cells / Q000276:immunology*; D051379:Mice; D008856:Microscopy, Fluorescence; D012908:Snails / Q000276:immunology*
D000373:Agglutinins; D000910:Antibodies, Heterophile; D006023:Glycoproteins
Reaktion heterophiler Agglutinine mit L-Zellen und unterschiedliche Toxizität von Anti-AHP gegenüber Fibroblasten und L-Zellen in vitro