[Chromosome aberrations induced by fortrin in human lymphocytes in cultures and in vivo].
Chromosome aberrations in human lymphocytes in vitro and in vivo were studied after the treatment with the five-functional alkylating agent photrine (an original Soviet antitumour drug). In concentrations above 10-7 M photrine caused chromosome breaks in vitro at 4.6.10-4 M completely diminished the mitotic activity in cultured cells. The aberrations were presented almost exclusively as single and paired fragments occasionally distributed among the chromosomes. In three patients treated with photrine cells with aberrative karyotypes ranged within 14-37.5%.
D000230:Adenocarcinoma / Q000188:drug therapy / Q000235:genetics; D000368:Aged; D000477:Alkylating Agents / Q000627:therapeutic use*; D001388:Aziridines / Q000627:therapeutic use*; D001389:Azirines / Q000627:therapeutic use*; D002478:Cells, Cultured; D002869:Chromosome Aberrations; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000188:drug therapy* / Q000235:genetics; D008214:Lymphocytes / Q000648:ultrastructure*; D008297:Male; D008875:Middle Aged; D009025:Morpholines / Q000627:therapeutic use; D010051:Ovarian Neoplasms / Q000188:drug therapy* / Q000235:genetics
D000477:Alkylating Agents; D001388:Aziridines; D001389:Azirines; D009025:Morpholines
Khromosomnye aberratsii, indutsirovannye fotrinom v limfotsitakh cheloveka v kul'ture in in vivo