[Effect of Central Asian cobra (Naja naja oxiana) venom on the biosynthesis of nucleic acids and protein in animal cells].
Cobra poison at a dose of 4 microng/kg of body weight intensified the 3H-thimidine incorporation into DNA of mice liver tissue; 20-40 microng/kg of the poison inhibited the incorporation. Single intraperitoneal administration of high doses of cobra poison (50-150 microng/kg) decreased the incorporation of 14C-thimidine into DNA 1.2-1.9-fold. Little doses of the poison increased the incorporation of 14C-hydrolysate of Chlorella protein into proteins of liver cells and the high doses inhibited this process. Microdoses of cobra poison caused a distinct increase in weight of experimental mice.
D000818:Animals; D002250:Carbon Radioisotopes; D002708:Chlorella; D004247:DNA / Q000096:biosynthesis*; D004305:Dose-Response Relationship, Drug; D008099:Liver / Q000187:drug effects / Q000378:metabolism; D051379:Mice; D014176:Protein Biosynthesis; D011492:Protein Hydrolysates / Q000378:metabolism; D012313:RNA / Q000096:biosynthesis*; D012910:Snake Venoms / Q000494:pharmacology*; D013154:Spleen / Q000187:drug effects / Q000378:metabolism; D013936:Thymidine / Q000378:metabolism; D013997:Time Factors; D014316:Tritium
D002250:Carbon Radioisotopes; D011492:Protein Hydrolysates; D012910:Snake Venoms; D014316:Tritium; D012313:RNA; D004247:DNA; D013936:Thymidine
Vliianie iada srednaziatskoĭ kobry na biosintez nulkeinovykh kislot i belka v kletkakh zhivotnykh