[Toxicity and pharmacological properties of carminomycin complex components].
Acute toxicity of the components of the carminomycin complex after intravenous administration to albino mice increased as follows. I less than II less than III. Component II induced a decrease in all the indices of the bone marrow and peripheral blood of the animals. It was most pronounced in dogs. The dogs died after administration of component II in the lethal doses as a result of the bone marrow aplasia. The indices of the functional state of the liver and kidneys in the animals after administration of components I and II changed slightly. Component III administered repeatedly to rabbits even in low doses induced significant impairments in the function of the liver and kidneys. Component II differed from component I by more pronounced cardiotoxicity. On the basis of the experimental data and the results published earlier component I is recommended for clinical trials as the least toxic one.
D000818:Animals; D000903:Antibiotics, Antineoplastic; D001786:Blood Glucose / Q000032:analysis; D001835:Body Weight / Q000187:drug effects; D002360:Carubicin / Q000494:pharmacology / Q000633:toxicity; D004285:Dogs; D005260:Female; D006410:Hematopoiesis / Q000187:drug effects; D007668:Kidney / Q000187:drug effects; D007677:Kidney Function Tests; D008099:Liver / Q000187:drug effects; D008111:Liver Function Tests; D008297:Male; D051379:Mice; D009929:Organ Size / Q000187:drug effects; D011817:Rabbits
D000903:Antibiotics, Antineoplastic; D001786:Blood Glucose; D002360:Carubicin
Toksichnost' i farmkologicheskie svoistva komponentov karminomitsinovogo kompleksa