[Angiotensin II inhibitors for the diagnosis and treatment of hypertension].
Specific antagonists of the renin angiotensin system have been used to investigate the role of this hormonal system in blood pressure homeostasis and in different types of experimental and clinical hypertension. Using this approach it was possible to show that renin via angiotensin participates actively in blood pressure maintenace, particularly following sodium depletion. Such antagonists, if available for oral administration and taken together with a diuretic, would be useful therapeutically.
D000328:Adult; D000804:Angiotensin II / Q000031:analogs & derivatives* / Q000037:antagonists & inhibitors*; D000818:Animals; D006801:Humans; D006973:Hypertension / Q000175:diagnosis / Q000188:drug therapy; D006977:Hypertension, Renal / Q000188:drug therapy; D008297:Male; D009842:Oligopeptides / Q000627:therapeutic use*; D051381:Rats; D012083:Renin / Q000032:analysis; D012504:Saralasin / Q000627:therapeutic use*; D012964:Sodium / Q000378:metabolism; D013722:Teprotide / Q000627:therapeutic use*
D009842:Oligopeptides; D000804:Angiotensin II; D012964:Sodium; D013722:Teprotide; D012083:Renin; D012504:Saralasin
Les inhibiteurs de l'angiotensine II pour le diagnostic et le traitement de l'hypertension