Effect of sulpiride on plasma prolactin in rats.
I.v. injection of sulpiride (S; 0.5-20 mug/100 g b.w.) caused a significant and dose-related increase in plasma prolactin (Prl) levels in urethane-anesthetized rats, with peak values occuring 10 min after the injection. L-dopa administration (2 mg/100 g b.w., i.v.) significantly blunted plasma Prl response to S(1 mug/100 g b.w., i.v.). S injection (1 mug/rat) into a lateral ventricle also raised plasma Prl significantly. Hypothalamic destruction resulted in a prominent increase of basal plasma Prl, which increased further following the injection of S. These results suggest that S stimulates Prl secretion by its possible direct action on the anterior pituitary.
D000818:Animals; D007031:Hypothalamus / Q000502:physiology; D007275:Injections, Intravenous; D007276:Injections, Intraventricular; D007980:Levodopa / Q000494:pharmacology; D008297:Male; D011388:Prolactin / Q000097:blood*; D051381:Rats; D013469:Sulpiride / Q000008:administration & dosage / Q000494:pharmacology*
D007980:Levodopa; D013469:Sulpiride; D011388:Prolactin