Ultrastructural aspects of Peptichemio action on mouse sarcoma 180.
The electron microscope study of the cellular elements originating from mice experimental tumours (sarcoma 180) treated and non-treated with Peptichemio showed alterations of the nuclear and cytoplasmic structures in the animals treated. The data herein accord fully with the results obtained by other histological, biochemical and biomolecular techniques and make it possible once again to lay stress on the double alkylating and antimetabolic action of this antitumour drug, very likely taking place simultaneously both at nuclear and cytoplasmic level.
D000818:Animals; D006056:Golgi Apparatus / Q000187:drug effects; D051379:Mice; D008928:Mitochondria / Q000187:drug effects; D009368:Neoplasm Transplantation; D009588:Nitrogen Mustard Compounds / Q000627:therapeutic use*; D010440:Peptichemio / Q000494:pharmacology / Q000627:therapeutic use*; D012510:Sarcoma 180 / Q000188:drug therapy / Q000648:ultrastructure
D009588:Nitrogen Mustard Compounds; D010440:Peptichemio