title: Synthesis and screening of some substituted 3.5-dioxopyrazolidines.
abstract: Seven new 3.5-dioxopyrazolidine derivatives, incorporating in their molecule a p-substituted benzoyl grouping, were synthesized. The preliminary screening of four selected compounds showed that 1-phenyl-2-[p-nitrobenzoyl]-4.4-diethyl-3.5-dioxopyrazolidine possesses a low order of antiinflammatory activity.
mesh_terms: D000818:Animals; D000893:Anti-Inflammatory Agents / Q000138:chemical synthesis; D004353:Drug Evaluation, Preclinical; D003368:Gossypium; D007249:Inflammation / Q000139:chemically induced; D010653:Phenylbutazone / Q000494:pharmacology; D011720:Pyrazoles / Q000138:chemical synthesis / Q000494:pharmacology; D051381:Rats
chemical_list: D000893:Anti-Inflammatory Agents; D011720:Pyrazoles; D010653:Phenylbutazone