[Quantitative determination of 7-phenoxyacetamidodesacetoxycephalosporanic acid].
7-Phenoxyacetamidodesacetoxycephalosporanic acid, an intermediate product in synthesis of cephalexin, was prepared by oxydation of phenoxymethylpenicillin into the respective sulphoxide and transformation of the latter. The UV-spectra of the reaction products were studied. A quantitative method is proposed for determination of 7-phenoxyacetamidodesacetoxycephalosporanic acid in the finished products based on estimation os the coefficient of specific extinction of the ethanol solutions at a wave length of 268 um in the UV-spectrum region in combination with semiquantitative estimation of the admixtures with the method of thin-layer chromatography.
D002506:Cephalexin / Q000138:chemical synthesis; D002511:Cephalosporins / Q000032:analysis*; D002855:Chromatography, Thin Layer; D013056:Spectrophotometry, Ultraviolet
D002511:Cephalosporins; D002506:Cephalexin
Kolichestvennoe opredelenie 7-fenoksiatsetamidodezatsetoksitsefalosporanovoĭ kisloty