Effect of immunosuppressive therapy on the serum glycoprotein levels in chronic aggressive hepatitis.
The sera of 24 patients with chronic aggressive hepatitis receiving combined immunosuppressive therapy were studied for the concentrations of the carbohydrate components of glycoproteins and the IgG, IgA, IgM, alpha-2-macroglobulin, coeruloplasmin, beta-1-C-globulin and transferrin levels over a period of 2 years. Liver biopsy was performed repeatedly in 50% of the cases. On the evidence of the results, combined immunosuppressive treatment is regarded as apt to normalize the serum concentrations of IgG, IgA, IgM and to reduce those of alpha-2-macroglobulin and coeruloplasmin. Among the carbohydrate components of glycoproteins only the amount of hexose was reduced.
D000328:Adult; D001379:Azathioprine / Q000494:pharmacology / Q000627:therapeutic use; D002241:Carbohydrates / Q000097:blood; D002570:Ceruloplasmin / Q000378:metabolism; D006023:Glycoproteins / Q000097:blood*; D006505:Hepatitis / Q000097:blood* / Q000188:drug therapy; D006601:Hexoses / Q000097:blood; D006801:Humans; D007070:Immunoglobulin A / Q000378:metabolism; D007074:Immunoglobulin G / Q000378:metabolism; D007075:Immunoglobulin M / Q000378:metabolism; D007166:Immunosuppressive Agents / Q000494:pharmacology / Q000627:therapeutic use*; D008297:Male; D011239:Prednisolone / Q000494:pharmacology / Q000627:therapeutic use; D012712:Serum Globulins / Q000378:metabolism; D014168:Transferrin / Q000378:metabolism
D002241:Carbohydrates; D006023:Glycoproteins; D006601:Hexoses; D007070:Immunoglobulin A; D007074:Immunoglobulin G; D007075:Immunoglobulin M; D007166:Immunosuppressive Agents; D012712:Serum Globulins; D014168:Transferrin; D011239:Prednisolone; D002570:Ceruloplasmin; D001379:Azathioprine