Effect of short- and long-term administrations of some drugs on rat intestinal flora. Short communication.
Two schedules of treatment were adopted for an experimental evaluation of drug induced alterations in mid-small intestinal flora of normal rats. Test substances were given orally twice daily for 3 days at large doses and once daily for 30 days at lower doses. Indometacin, benzydamine, phenylbutazone, pheprazone, picosulfol, magnesium sulfate, tolbutamide, phenformin, dexamethasone acetate and prednisolone acetate were tested. Drug-induced alterations in rat intestinal flora resulted more evidently following multiple short-time treatments.
D000284:Administration, Oral; D000818:Animals; D001419:Bacteria / Q000187:drug effects; D004334:Drug Administration Schedule; D004353:Drug Evaluation, Preclinical / Q000379:methods; D007421:Intestine, Small / Q000382:microbiology*; D008297:Male; D004364:Pharmaceutical Preparations / Q000008:administration & dosage*; D051381:Rats; D013997:Time Factors
D004364:Pharmaceutical Preparations