title: Effect of dimethyl sulfoxide and hydrogen peroxide on tissue gas tensions.
abstract: Tissue gas levels were measured in experimental skin flaps in rabbits, rats, and pigs. Devascularization of the flaps led to a fall in PO2 and a rise in PCO2 levels. Application of DMSO to ischemic rabbit flaps led to a fall in PCO2, DMSO and H2O2 led to a rise in PO2, an effect that lasted up to 90 min. Neither drug had an effect on the gas levels of flaps in either rats or pigs.
mesh_terms: D000818:Animals; D002245:Carbon Dioxide / Q000032:analysis; D004058:Diffusion; D004121:Dimethyl Sulfoxide / Q000494:pharmacology*; D006861:Hydrogen Peroxide / Q000494:pharmacology*; D009584:Nitrogen / Q000032:analysis; D010100:Oxygen / Q000032:analysis; D011312:Pressure; D011817:Rabbits; D051381:Rats; D012039:Regional Blood Flow / Q000187:drug effects; D012867:Skin / Q000098:blood supply / Q000187:drug effects*; D013045:Species Specificity; D013552:Swine
chemical_list: D002245:Carbon Dioxide; D006861:Hydrogen Peroxide; D009584:Nitrogen; D010100:Oxygen; D004121:Dimethyl Sulfoxide