Dose-dependent ultrastructural changes induced by tetracycline in developing dental tissues of the rat.
Tetracycline was administered to rats in varying doses in order to study the likelihood of ultrastructural alterations to ameloblasts and to study odontoblasts and dentin as well. The changes caused by tetracycline to the mineralization of dentin and the ultrastructural changes to the odontoblasts and ameloblasts increased with larger doses.
D000565:Ameloblasts / Q000187:drug effects* / Q000648:ultrastructure; D000818:Animals; D000831:Animals, Newborn; D003593:Cytoplasm / Q000648:ultrastructure; D003804:Dentin / Q000187:drug effects* / Q000648:ultrastructure; D004305:Dose-Response Relationship, Drug; D004721:Endoplasmic Reticulum / Q000648:ultrastructure; D009804:Odontoblasts / Q000187:drug effects* / Q000648:ultrastructure; D051381:Rats; D013752:Tetracycline / Q000494:pharmacology*; D014083:Tooth Germ / Q000187:drug effects* / Q000648:ultrastructure
D013752:Tetracycline