title: Spironolactone-associated aggravation of renal functional impairment.
abstract: Five patients in whom deterioration in renal function was associated with the use of the aldosterone antagonist, spironolactone, are reported. Care in the use of this drug is urged, especially in the elderly. Patients with known renal functional impairment should not receive this agent.
mesh_terms: D000368:Aged; D005260:Female; D006801:Humans; D006947:Hyperkalemia / Q000139:chemically induced; D007674:Kidney Diseases / Q000139:chemically induced*; D008875:Middle Aged; D013148:Spironolactone / Q000009:adverse effects*
chemical_list: D013148:Spironolactone