[Studies on the epidemiology of malignant tumors, systemic diseases and leukemia in children (author's transl)].
The analysis of statistical data on the incidence of leukemia in children in the German Democratic Republic between 1968 and 1973 gives no evidence for increasing risk of disease. Incidence in the G.D.R. is about the same as reported in literature. It seems that in the etiology and natural history of malignant tumors and hemoblastosis in children, constitutional and genetic as well as environmental factors are involved. They may work single or combined. Probably, malignant tumors or malignant systemic disease arise if the immune system fails to destroy endogenous or transplanted tumor cells.
D000293:Adolescent; D000367:Age Factors; D002648:Child; D002675:Child, Preschool; D002869:Chromosome Aberrations; D004200:Diseases in Twins; D005260:Female; D005859:Germany, East; D006801:Humans; D007153:Immunologic Deficiency Syndromes / Q000150:complications; D007223:Infant; D007231:Infant, Newborn; D007938:Leukemia / Q000453:epidemiology*; D007945:Leukemia, Lymphoid / Q000453:epidemiology; D007951:Leukemia, Myeloid / Q000453:epidemiology; D015470:Leukemia, Myeloid, Acute / Q000453:epidemiology; D008297:Male; D009369:Neoplasms / Q000453:epidemiology* / Q000235:genetics / Q000401:mortality; D012737:Sex Factors
Untersuchungen zur Epidemiologie von malignen Tumoren, Systemerkrankungen und Leukämien im Kindesalter