Thymoma and chronic myelogenous leukemia: a case report.
A case of epithelial thymoma occurring synchronously with Philadelphia chromosome-positive chronic myelogenous leukemia and urinary bladder carcinoma in a 76-year-old man is described. Thymomas have been associated with numberous hematologic, collagen-vascular and autoimmune disease states, as well as with an increased incidence of nonthymic malignancy. Human thymoma-associated leukemia is, however, extremely unusual, despite the well-documented role of the thymus in leukemogenesis in experimental animals. No previous literature reports of thymoma associated with chronic myelogeneous leukemia were found. A review of long-term followup data of surviving thymoma patients is necessary to determine if an increased propensity to develop leukemia is present in present in patients with thymoma.
D000368:Aged; D002295:Carcinoma, Transitional Cell / Q000150:complications*; D006801:Humans; D007951:Leukemia, Myeloid / Q000150:complications*; D008297:Male; D009378:Neoplasms, Multiple Primary; D013945:Thymoma / Q000150:complications* / Q000473:pathology; D013953:Thymus Neoplasms / Q000150:complications* / Q000473:pathology; D001749:Urinary Bladder Neoplasms / Q000150:complications*