title: [Primary healing of intraoral bone defects under the effect of local and general antibacterial prophylaxis].
abstract: On the basis of 4,700 cases, experience is reported which has been gained over 15 years with a method developed in Tübingen for the primary filling of intraoral bone defects which are big and/or especially jeoplardized by infection. To find an optimum antibacterial prophylaxis for undisturbed primary healing, the operative removal of a lower wisdom tooth is used as an example to compare groups of cases in which either only local prophylaxis of additional general prophylaxis was applied. Comparison of the results with the findings of other authors shows that local implantation of antibacterial substances is superior to an exclusively antibiotic general therapy and that the best results may be expected by simultaneous implantation and general therapy. The findings also cast a light on the importance of exact technical skills in the treatment of wounds and on the considerable influence of the type of gelatine sponge on the stabilization of blood coagulation.
mesh_terms: D000287:Administration, Topical; D000900:Anti-Bacterial Agents / Q000008:administration & dosage*; D000891:Anti-Infective Agents, Local / Q000627:therapeutic use; D004343:Drug Implants; D005781:Gelatin Sponge, Absorbable / Q000627:therapeutic use; D006801:Humans; D008963:Molar; D010406:Penicillins / Q000627:therapeutic use; D013530:Surgical Wound Infection / Q000517:prevention & control*; D014081:Tooth Extraction; D014945:Wound Healing
chemical_list: D000900:Anti-Bacterial Agents; D000891:Anti-Infective Agents, Local; D004343:Drug Implants; D010406:Penicillins
vernacular_title: Die primäre Heilung intraoraler Knochendefekte unter dem Einfluss lokaler und allgemeiner antibakterieller Prophylaxe