title: Osteosarcoma associated with metallic implants. Report of two cases in dogs.
abstract: This is a report of two dogs in which osteosarcomas arose in association with metallic orthopedic implants. One neoplasm occurred in the distal humerus of a 12-year-old Doberman Pinscher. A stainless steel intramedullary pin had been implanted in the bone 11 years previously. Upon removal, corrosion of the pin was noted. The second neoplasm arose in the proximal tibia of a 12-year-old Irish Wolfhound. Six years previously, a fracture of the tibia had been repaired with a plate and screws made of the same type stainless steel, type 316L, by the same manufacturer. No corrosion appeared to have occured. Infection had not occured in either animal.
mesh_terms: D000818:Animals; D001859:Bone Neoplasms / Q000209:etiology / Q000662:veterinary*; D004283:Dog Diseases / Q000209:etiology*; D004285:Dogs; D006810:Humeral Fractures / Q000662:veterinary; D006811:Humerus; D008670:Metals / Q000009:adverse effects*; D009984:Orthopedic Fixation Devices / Q000009:adverse effects*; D012516:Osteosarcoma / Q000209:etiology / Q000662:veterinary*; D013977:Tibia; D013978:Tibial Fractures / Q000662:veterinary
chemical_list: D008670:Metals