Immunoglobulin and granulocyte cytochemical reactions in L-asparaginase treated children with acute lymphoblastic leukemia.
The dose-dependent effect of L-asparaginase (Crasnitin, Bayer) on the serum IgG, IgA and IgM content was studied in 14 children with acute lymphoblastic leukemia. This effect was less evident in the intracellular metabolism of peripheral blood granulocytes (studied by the NBT test), in the myeloperoxidase and alkaline phosphatase activities and in the serum glycogen and lipid content.
D000293:Adolescent; D000469:Alkaline Phosphatase / Q000097:blood*; D001215:Asparaginase / Q000627:therapeutic use*; D002648:Child; D002675:Child, Preschool; D006003:Glycogen / Q000378:metabolism; D006098:Granulocytes / Q000378:metabolism; D006801:Humans; D007070:Immunoglobulin A / Q000032:analysis; D007074:Immunoglobulin G / Q000032:analysis; D007075:Immunoglobulin M / Q000032:analysis; D007136:Immunoglobulins / Q000032:analysis; D007945:Leukemia, Lymphoid / Q000097:blood / Q000188:drug therapy / Q000201:enzymology / Q000276:immunology*; D007962:Leukocytes / Q000378:metabolism*; D050356:Lipid Metabolism; D009195:Peroxidase / Q000097:blood*; D010544:Peroxidases / Q000097:blood*; D013601:T-Lymphocytes / Q000276:immunology
D007070:Immunoglobulin A; D007074:Immunoglobulin G; D007075:Immunoglobulin M; D007136:Immunoglobulins; D006003:Glycogen; D010544:Peroxidases; D009195:Peroxidase; D000469:Alkaline Phosphatase; D001215:Asparaginase