Laboratory and clinical evaluation of the radiation-potentiating activity of ethyl-N-bis (2,2-dimethylethylamidinophosphoro) carbamate (AB-132).
Ethyl-N-bis (2,2-dimethylethylamidinophosphoro) carbamate (AB-132) has been shown to potentiate the effect of whole-body radiation on inhibition of splenomegaly induced by Friend leukemia virus in ICR/H Swiss mice. The combined effect of AB-132 and radiation does not appear to be related to Friend virus inhibition but seems to act on the proliferating tumor in the spleen. Nine children with advanced cancer were treated with combined administration of local radiation and systemic AB-132. Although regression of tumor was seem, no dramatic effect on survival was apparent. One case of metastatic Ewing's sarcoma showed systemic tumor response to AB-132 in addition to localized response to radiation. Bone marrow depression appeared to be the main side effect of combination therapy.
D000818:Animals; D001389:Azirines / Q000627:therapeutic use*; D002648:Child; D005260:Female; D005622:Friend murine leukemia virus; D006801:Humans; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D009362:Neoplasm Metastasis; D009369:Neoplasms / Q000188:drug therapy / Q000532:radiotherapy; D009929:Organ Size; D011830:Radiation Effects; D011838:Radiation-Sensitizing Agents / Q000627:therapeutic use*; D013154:Spleen / Q000528:radiation effects; D013163:Splenomegaly / Q000209:etiology / Q000517:prevention & control; D014965:X-Rays
D001389:Azirines; D011838:Radiation-Sensitizing Agents