title: The influence of intrauterine saline infusion on luteal function and cyclical activity in the mare.
abstract: Intrauterine saline infusion in the dioestrous mare shortened the ovulatory interval by inducing premature luteolysis. Plasma progestagen levels began to decrease approximately 1 day after the infusion and had declined to less than 1-0 ng/ml in 4 days. The CL, including others formed from ovulations during dioestrus, must be 4 to 5 days old before intrauterine saline will induce luteolysis. Of 10 mares infused on Day 4 or 5 after ovulation, only six had a shortened ovulatory interval. Of 10 mares infused on Day 6 or 7 after ovulation, seven had a shortened ovulatory interval and three failed to respond due to the occurrence of a dioestrous ovulation near the time of infusion. In those mares which responded to treatment, the interval from saline infusion to the beginning of oestrus and to ovulation was 5 to 6 days and 9 to 10 days, respectively.
mesh_terms: D000818:Animals; D003338:Corpus Luteum / Q000187:drug effects*; D004971:Estrus / Q000187:drug effects*; D005260:Female; D006736:Horses / Q000502:physiology*; D010060:Ovulation / Q000187:drug effects; D011247:Pregnancy; D011372:Progestins / Q000097:blood; D012965:Sodium Chloride / Q000494:pharmacology*; D014599:Uterus / Q000187:drug effects
chemical_list: D011372:Progestins; D012965:Sodium Chloride