Testing mutagenic properties with the dominant lethal test on the male mouse.
Mytagecity studies were carried out with fluorescent whitening agents (FWAs) using the dominant lethal test on male mice. Own tests with five FWAs, and those of KEPLINGER, et al. (Toxicol. Appl. Pharmacol.27: 494-506, 1974), with four FWAs, are described. In our tests, acute oral administration of five FWAs at a dose of 5000 mg/kg body weight gave no evidence of a mutagenic effect during 8 weeks' mating. The FWAs used were three bis(triazinylamino)stilbenedisulfonic acid derivatives and a 1,3-diphenyl-2-pyrazoline derivative. The results of the tests carried out by KEPLINGER, et al. showed that intraperitoneal injection of the four FWAs produced no mutagenic effect during six weeks' mating; the whiteners used were a triazolylstilbenemonosulfonic acid derivative (50 mg/kg), two bis(triazinylamino)stilbenedisulfonic acid derivatives (50 mg/kg) and a bis(sulfostyryl)biphenyl derivative (10 mg/kg).
D000818:Animals; D001713:Biphenyl Compounds / Q000494:pharmacology; D004396:Coloring Agents / Q000494:pharmacology*; D004622:Embryo, Mammalian / Q000187:drug effects; D005260:Female; D005298:Fertility / Q000187:drug effects; D005799:Genes, Dominant / Q000187:drug effects*; D005804:Genes, Lethal / Q000187:drug effects*; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D009153:Mutagens / Q000494:pharmacology*; D011247:Pregnancy; D011720:Pyrazoles / Q000494:pharmacology; D013267:Stilbenes / Q000494:pharmacology; D014230:Triazoles / Q000494:pharmacology
D001713:Biphenyl Compounds; D004396:Coloring Agents; D009153:Mutagens; D011720:Pyrazoles; D013267:Stilbenes; D014230:Triazoles