Thorotrast-induced extraskeletal osteosarcoma of the cervical region. Report of a case.
This is the seventh reported case of soft tissue sarcoma attributed to thorotrast extravasated during the course of an injection for arteriography. An extraskeletal osteosarcoma occurring the cervical region of a 51-year-old man 30 years after a cerebral arteriogram is presented. The other reported cases include a fibrosarcoma, two neurofibrosarcomas, two spindle cell sarcomas, and an extraskeletal chondrosarcoma. The latency period has varied from 5 to 30 years. The thorotrast granules are readily identified in macrophages near or adjacent to the tumor, and the demonstration of alpha tracks on autoradiographs is diagnostic.
D006801:Humans; D008875:Middle Aged; D009381:Neoplasms, Radiation-Induced / Q000473:pathology; D012516:Osteosarcoma / Q000209:etiology* / Q000473:pathology; D011859:Radiography / Q000009:adverse effects*; D012983:Soft Tissue Neoplasms / Q000209:etiology* / Q000473:pathology; D013911:Thorium Dioxide / Q000009:adverse effects*
D013911:Thorium Dioxide