Adriamycin in the treatment of childhood acute leukemia. A Southwest Oncology Group study.
Sixty-six children with acute leukemia, in advanced stages of their disease and resistant to conventional chemotherapy, received adriamycin for remssion induction. Seventeen of 46 (37%) evaluable children with acute lymphocytic leukemia achieved a complete remission, and 5 (11%) achieved a partial remission. Two of 12 evaluable children with acute myelogenous leukemia achieved a complete remission, while an additional 3 achieved a partial remission. Two children with erythroleukemia also achieved a complete remission. Previous therapy with daunorubicin did not affect the response rate. The main toxicities observed with adriamycin were myelosuppression, fever, nausea and vomiting, stomatitis, alopecia, and cardiac toxicity (ST segment changes and arrhythmias).
D000293:Adolescent; D000505:Alopecia / Q000139:chemically induced; D001853:Bone Marrow / Q000187:drug effects; D002648:Child; D002675:Child, Preschool; D003630:Daunorubicin / Q000627:therapeutic use; D004317:Doxorubicin / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D005260:Female; D005334:Fever / Q000139:chemically induced; D006321:Heart / Q000187:drug effects; D006801:Humans; D007223:Infant; D007938:Leukemia / Q000188:drug therapy*; D004915:Leukemia, Erythroblastic, Acute / Q000188:drug therapy; D007945:Leukemia, Lymphoid / Q000188:drug therapy; D015470:Leukemia, Myeloid, Acute / Q000188:drug therapy; D008297:Male; D009325:Nausea / Q000139:chemically induced; D012075:Remission, Spontaneous; D013280:Stomatitis / Q000139:chemically induced
D004317:Doxorubicin; D003630:Daunorubicin