title: Interactions between nutritional factors and drug biotransformations in man.
abstract: This study was undertaken to examine the influence of nutritional factors on the activity of the mixed function oxidase system in man, which is cytochrome P-450 dependent. Three normal volunteers were fed a low carbohydrate-high protein diet for 2 weeks, followed by a high carbohydrate-low protein diet for the follwoing 2 weeks. At the end of each test diet period, the plasma elimination rates of antipyrine and theophylline were determined. The mean plasma half-life for antipyrine was 17.5 hr on the high carbohydrate-low protein diet and 9.2 hr on the low carbohydrate-high protein diet. The mean plasma half-life for theophylline was 8.9 hr on the high carbohydrate-low protein diet and 5.9 hr on the low carbohydrate-high protein diet. These data demonstrate marked influences of dietary carbohydrate and/or protein ingestion on oxidative biotransformation of drugs in man.
mesh_terms: D000328:Adult; D000983:Antipyrine / Q000378:metabolism*; D001711:Biotransformation; D004040:Dietary Carbohydrates; D004044:Dietary Proteins; D006801:Humans; D008297:Male; D006899:Mixed Function Oxygenases / Q000378:metabolism*; D010088:Oxidoreductases / Q000378:metabolism*; D013806:Theophylline / Q000378:metabolism*
chemical_list: D004040:Dietary Carbohydrates; D004044:Dietary Proteins; D013806:Theophylline; D006899:Mixed Function Oxygenases; D010088:Oxidoreductases; D000983:Antipyrine