The effect of vincristine on dentinogenesis in the rat incisor.
A preliminary report on the histomorphologic effects of vincristine on rat incisor dentinogenesis is presented. Niche-like areas of osteodentin and a faint incremental line in the dentin were the main derangements observed after single injections of the drug. The severity of the lesions was dose-dependent.
D000818:Animals; D003810:Dentinogenesis / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D004353:Drug Evaluation, Preclinical; D007180:Incisor / Q000187:drug effects*; D007275:Injections, Intravenous; D051381:Rats; D014750:Vincristine / Q000008:administration & dosage / Q000494:pharmacology*
D014750:Vincristine