Interferon treatment of mice: enhanced expression of histocompatibility antigens on lymphoid cells.
Treatment of young and mature mice with potent mouse interferon preparations results in a marked enhancement of the expression of histocompatibility antigens on the surface of thymocytes and splenic lymphocytes as measured by an enhanced absorption of alloantiserum. We postulate that such modifications of the cell surface may reflect an effect of interferon on lymphocyte maturation and may be relevant to the effect of interferon on lymphocyte function.
D000367:Age Factors; D000818:Animals; D003348:Cortisone / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D006649:Histocompatibility Antigens; D007369:Interferon Inducers / Q000494:pharmacology; D007372:Interferons / Q000494:pharmacology*; D007518:Isoantibodies; D008214:Lymphocytes / Q000276:immunology*; D051379:Mice; D008811:Mice, Inbred DBA; D009522:Newcastle disease virus / Q000276:immunology; D013154:Spleen / Q000276:immunology; D013950:Thymus Gland / Q000276:immunology
D006649:Histocompatibility Antigens; D007369:Interferon Inducers; D007518:Isoantibodies; D007372:Interferons; D003348:Cortisone