Molecular mechanism for oscillation in flagella and muscle.
Two-state models for muscle cross-bridges, of the type originally detailed by Andrew Huxley, were examined. Rate functions for cross-bridge attachment and detachment can be chosen which yield a steady-state force-velocity relationship appropriate for the spontaneous generation of oscillatory contractions. Computer simulations have been used to demonstrate oscillation of such cross-bridge systems, and to demonstrate that distribution of this type of local shear oscillation along the length of a flagellum is sufficient for the generation of propagated bending waves.
D003201:Computers; D005407:Flagella / Q000502:physiology* / Q000648:ultrastructure; D008433:Mathematics; D008954:Models, Biological; D009132:Muscles / Q000502:physiology* / Q000648:ultrastructure; D009991:Oscillometry