[Functional analysis in experimental respiratory distress syndrome (author's transl)].
After injection of an anti-lung -serum a respiratory distress syndrome could be produced in spontaneously-breathing guinea pigs. Reduced compliance, increased resistance and work of breathing was found. Morphological investigations showed intraalveolar and interstitial bleedings and a lung edema. Biochemically a decreased total phospholipid content could be found. Surface tension characteristics, examined with the Langmuir balance, were deteriorated. A complete restitution of surface tension parameters and total phospholipid content was obtained by administration of bromhexin metabolit Na 872.
D000818:Animals; D001784:Blood Gas Analysis; D004195:Disease Models, Animal; D006168:Guinea Pigs; D006801:Humans; D007231:Infant, Newborn; D008170:Lung Compliance; D010743:Phospholipids / Q000097:blood; D012127:Respiratory Distress Syndrome, Newborn / Q000097:blood / Q000503:physiopathology*; D013500:Surface Tension
D010743:Phospholipids
Funktionsanalyse beim experimentellen Atemnotsyndrom im chronischen Versuch