title: Fluid therapy in the critically injured patient.
abstract: Sufficient clotting factors to ensure coagulation and replacement of lost volume and oxygen-carrying capacity are necessary to obviate many of the complications that may occur when massive transfusions are used in patients with multiple injuries. A regimen that has been successful includes immediate infusion of plasma protein fraction, packed red cells, fresh-frozen plasma, and nonspecific platelets.
mesh_terms: D001778:Blood Coagulation Disorders / Q000378:metabolism / Q000628:therapy; D001779:Blood Coagulation Factors / Q000378:metabolism / Q000627:therapeutic use; D001792:Blood Platelets; D001798:Blood Proteins / Q000627:therapeutic use; D001803:Blood Transfusion; D004211:Disseminated Intravascular Coagulation / Q000628:therapy; D005337:Fibrin / Q000378:metabolism; D006801:Humans; D012131:Respiratory Insufficiency / Q000209:etiology; D013921:Thrombocytopenia / Q000209:etiology; D065227:Transfusion Reaction; D014947:Wounds and Injuries / Q000628:therapy*
chemical_list: D001779:Blood Coagulation Factors; D001798:Blood Proteins; D005337:Fibrin