title: Acute and chronic effects of methotrexate on hepatic, pulmonary, and skeletal systems.
abstract: With the progressive improvement in the survival of children with acute lymphocytic leukemia, the question of late effects of therapy on normal tissue becomes a more significant problem. In a review of a large number of children who have received long-term treatment with chemotherapy, especially methotrexate, a significant increase in the serious effects on hepatic, pulmonary, and skeletal tissue was noted. A review of the methotrexate-induced acute and chronic changes seen in these tissues is the basis for this report.
mesh_terms: D001842:Bone and Bones / Q000187:drug effects*; D006801:Humans; D007945:Leukemia, Lymphoid / Q000188:drug therapy; D008099:Liver / Q000187:drug effects*; D008168:Lung / Q000187:drug effects*; D008727:Methotrexate / Q000009:adverse effects* / Q000627:therapeutic use; D010024:Osteoporosis / Q000139:chemically induced; D011014:Pneumonia / Q000139:chemically induced; D011658:Pulmonary Fibrosis / Q000139:chemically induced / Q000473:pathology; D012600:Scoliosis / Q000139:chemically induced
chemical_list: D008727:Methotrexate