Differentiation of erythroleukemia cells in vitro: properties of chemical inducers.
Murine erythroleukemia cells growing in vitro can be induced to differentiate. The physical properties of chemical inducers has been defined and has permitted the recognition of a variety of potent inducers. The compounds can be linear, branched, or aromatic molecules. Some are methylated. All are low molecular weight basic compounds which are hydrophylic and are potent cryoprotective agents. The inducing effects of combinations of some agents are synergistic while others are additive. These observations will permit a rational search for inducing agents with increased potency and decreased toxicity.
D000081:Acetamides / Q000494:pharmacology*; D000096:Acetone / Q000494:pharmacology; D000818:Animals; D001769:Blood; D002454:Cell Differentiation / Q000187:drug effects*; D002460:Cell Line; D003451:Cryoprotective Agents; D003470:Culture Media; D003956:Dialysis; D004121:Dimethyl Sulfoxide / Q000494:pharmacology*; D004347:Drug Interactions; D004357:Drug Synergism; D005026:Ethylene Glycols / Q000494:pharmacology; D005559:Formamides / Q000494:pharmacology; D006418:Heme / Q000096:biosynthesis; D004915:Leukemia, Erythroblastic, Acute; D051379:Mice; D008970:Molecular Weight; D004364:Pharmaceutical Preparations / Q000032:analysis; D011725:Pyridines / Q000494:pharmacology*; D014508:Urea / Q000494:pharmacology
D000081:Acetamides; D003451:Cryoprotective Agents; D003470:Culture Media; D005026:Ethylene Glycols; D005559:Formamides; D004364:Pharmaceutical Preparations; D011725:Pyridines; D000096:Acetone; D006418:Heme; D014508:Urea; D004121:Dimethyl Sulfoxide