Uveitis and intraocular lenses.
Discs of polymethylmethacrylate containing 0-5 per cent. unpolymerized monomer were heated to create increasing concentrations of unpolymerized fragments up to 3-7 per cent. These fragments were then studied in tissue culture and in the anterior chambers of rabbits. No toxicity was evident in culture nor was there a difference in anterior segment response to the discs containing various concentrations of monomer. It would appear that the inflammatory response after implantation is predominantly mechanical in origin.
D000818:Animals; D002478:Cells, Cultured; D007909:Lenses; D008768:Methylmethacrylates / Q000633:toxicity*; D019736:Prostheses and Implants / Q000009:adverse effects*; D011817:Rabbits; D014606:Uveitis, Anterior / Q000209:etiology*
D008768:Methylmethacrylates