title: Reddening of the upper central incisors associated with periapical granuloma in lepromatous leprosy.
abstract: Four years after starting treatment for lepromatous leprosy in England a male Pakistani aged 26 was found to have red discoloration of the upper central incisor teeth. A radiograph suggested periapical abscess on the right with haziness in a corresponding area on the left. Right apicectomy was performed with removal of a solid mass attached to the apex, sections revealing a lepromatous infiltrate with acid-fast fragments of Mycobacterium leprae in the cytoplasm of foamy macrophages. Clinical and archaeological evidence for the frequent involvement of these teeth in lepromatous leprosy is reviewed. The upper incisor area is relatively cool, a factor which may be of critical importance for the lodgement and multiplication of this bacillus, as it is in other body sites in lepromatous leprosy.
mesh_terms: D000328:Adult; D006801:Humans; D007180:Incisor; D007918:Leprosy / Q000150:complications*; D008297:Male; D010484:Periapical Granuloma / Q000150:complications* / Q000473:pathology; D014075:Tooth Discoloration / Q000209:etiology*