title: In vitro granulocytic stem cell clonogenic capacity of marrow and spleen cells from mice infected with Rauscher leukemia virus.
abstract: Bone marrow and spleen cells from early, midstage, and terminal Rauscher leukemia virus (RLV-A)-infected erythroleukemic mice were assessed for granulocyte stem cell (CFU-c) clongenic capacity in the semisolid agar culture assay. It was found that marrow CFU-c concentrations exceeded normal in early stages of this erythroid disease but returned to near normal values during mid- and terminal phases. Splenic CFU-c concentrations, on the other hand, were generally higher than control values for all stages of the disease. These results are discussed with reference to the pathogenesis of RLV-A disease.
mesh_terms: D000818:Animals; D002478:Cells, Cultured; D002999:Clone Cells; D006098:Granulocytes / Q000276:immunology*; D006400:Hematocrit; D006412:Hematopoietic Stem Cells / Q000276:immunology*; D004915:Leukemia, Erythroblastic, Acute / Q000276:immunology* / Q000473:pathology; D007962:Leukocytes / Q000276:immunology*; D051379:Mice; D009929:Organ Size; D011925:Rauscher Virus; D013154:Spleen / Q000276:immunology* / Q000473:pathology