title: [Reaction of the middle ear mucous membrane in tubal obstruction].
abstract: 1. Tubal obstruction causes a rapid rise in transepithelial cytopempsis. The squamous epithelial cells show numerous vesicles carrying subepithelial fluid (extracellular fluid) to the middle ear cavity. 24 hours following tubal obstruction a widespread rupture of the epithelial junctions can be observed. Subepithelial fluid, consisting of lymphfluid, transsudate and later exsudate, enters the middle ear cavity without passing a cellular barrier. 2. Long lasting negative pressure provoces a cellular differentiation (metaplasia!) of the formerly squamous epithelium to a high, cylindric cell layer with new functions: ciliary movement and secretory activity. 3. Ablation of the tympanic membrane to expose the middle ear to air after 2-4 days, causes a stop in the epithelial differentiation but no regeneration to the normal histological flat formation. 4. Studies of samples of human middle ear mucosa in serous otitis or sero-mucous otitis show exactly the same results as during the different stages of our animal experiments.
mesh_terms: D000818:Animals; D001485:Basement Membrane / Q000648:ultrastructure; D002471:Cell Transformation, Neoplastic; D003593:Cytoplasm / Q000648:ultrastructure; D004432:Ear, Middle / Q000473:pathology* / Q000648:ultrastructure; D004847:Epithelial Cells; D004848:Epithelium / Q000648:ultrastructure; D005064:Eustachian Tube; D005110:Extracellular Space / Q000648:ultrastructure; D006168:Guinea Pigs; D006801:Humans; D007365:Intercellular Junctions / Q000648:ultrastructure; D009092:Mucous Membrane / Q000473:pathology / Q000648:ultrastructure; D010040:Otosclerosis / Q000473:pathology; D011312:Pressure; D014432:Tympanic Membrane / Q000648:ultrastructure
vernacular_title: Die Reaktion der Mittelohrschleimhaut bei Tubenverschluss