Agglutination of peripheral blood lymphocytes from cancer patients and not from healthy controls, with the F2A1 histone fraction.
A simple, rapid histone agglutination test (HAT) is described. It consists of incubation in microplates or in microtubes of blood lymphocytes isolated from cancer patients and patients with non-malignant diseases with microquantities of histone fraction F2A1. Positive reaction is shown by massive agglutination of lymphocytes of the patients tested (126 subjects): this test was positive in 76% of cases. All controls (59 subjects) were negative.
D000293:Adolescent; D005260:Female; D006386:Hemagglutination Tests / Q000379:methods; D006657:Histones / Q000276:immunology*; D006801:Humans; D007945:Leukemia, Lymphoid / Q000276:immunology; D007958:Leukocyte Count; D008214:Lymphocytes / Q000276:immunology*; D008297:Male; D009369:Neoplasms / Q000276:immunology*
D006657:Histones