Brain calcification in a case of acute lymphoblastic leukaemia.
Cortical calcifications, ween on X-ray in the brain of achild suffering from leukaemia, were submitted to morphological and chemical analysis. The morphology was studied by a combination of low teperature  ashing and microscanning. The calcification principally affected axons and capillary walls and consisted of  spherules amalgamated into hollow cylinders. The results of chemical analysis of the calcified material were compared and structure of both types of  calcification were similar, but the Mn concentration washigher in case of Fahr's disease. X-ray diffraction showed that the calcification consisted of amorphous calcium phosphate and acid calcium orthophosphate, most probably precursors of hydroxyapatite..
D001921:Brain / Q000648:ultrastructure; D001923:Brain Chemistry; D001927:Brain Diseases / Q000209:etiology* / Q000473:pathology; D002114:Calcinosis / Q000209:etiology* / Q000473:pathology; D002118:Calcium; D002648:Child; D003300:Copper; D006801:Humans; D007501:Iron; D007945:Leukemia, Lymphoid / Q000150:complications* / Q000473:pathology / Q000532:radiotherapy; D008274:Magnesium; D008297:Male; D008345:Manganese; D008855:Microscopy, Electron, Scanning; D010758:Phosphorus; D011878:Radiotherapy / Q000009:adverse effects; D013054:Spectrophotometry, Atomic; D013055:Spectrophotometry, Infrared; D014961:X-Ray Diffraction; D015032:Zinc
D010758:Phosphorus; D008345:Manganese; D003300:Copper; D007501:Iron; D008274:Magnesium; D015032:Zinc; D002118:Calcium