Growth of human cancer cells as lung metastases in immunologically tolerant rats.
Newborn rats were made tolerant to human cell antigens by intravenous injection of Amnion B cells, a permanet human cell line of normal origin. At various intervals thereafter each animal, and nontolerant litter mate controls were challenged by SC and IV injections of the malignant human cell line J-III. Tumor nodules of J-III cells grew SC and in the lungs of most of the tolerant rats challenged at ages from 7 to 14 days, but not in their controls. Challenge at age 19 days produced SC tumors but there was no growth from the IV inoculum.
D000367:Age Factors; D000818:Animals; D001835:Body Weight; D002460:Cell Line; D007108:Immune Tolerance; D007275:Injections, Intravenous; D007279:Injections, Subcutaneous; D007951:Leukemia, Myeloid; D008175:Lung Neoplasms / Q000276:immunology* / Q000473:pathology; D009362:Neoplasm Metastasis; D009368:Neoplasm Transplantation; D009929:Organ Size; D051381:Rats; D014183:Transplantation, Heterologous