Growth and hormone control mechanisms in osteosarcoma. Evidence for a new therapeutic approach.
The association between osteosarcoma and growth, including altered carbohydrate metabolism has been investigated in 5 osteosarcoma patients. Serum from an adolescent osteosarcoma patient has been noted to consistently enhance 3-H-thymidine uptake in cultured chondrocytes and tumor cells. Females survive osteosarcoma more frequently than males. In vitro serum-enhanced proliferation of osteosarcoma cells is suppressed by estradiol.
D000293:Adolescent; D000328:Adult; D001786:Blood Glucose; D001859:Bone Neoplasms / Q000378:metabolism*; D001842:Bone and Bones / Q000378:metabolism; D050260:Carbohydrate Metabolism; D002356:Cartilage / Q000473:pathology; D046508:Culture Techniques; D004958:Estradiol / Q000097:blood; D005260:Female; D005951:Glucose Tolerance Test; D006128:Growth; D013006:Growth Hormone / Q000097:blood*; D006801:Humans; D007328:Insulin / Q000097:blood; D008297:Male; D012516:Osteosarcoma / Q000097:blood / Q000378:metabolism* / Q000473:pathology / Q000628:therapy; D012189:Retrospective Studies; D012744:Sex Ratio
D001786:Blood Glucose; D007328:Insulin; D004958:Estradiol; D013006:Growth Hormone