Isolation of an inhibitor of DNA synthesis specific for normal and malignant mammary cells.
A small-molecular-weight inhibitor of DNA synthesis, specific for normal and malignant mammary cells but devoid of species-specificity, has been isolated from bovine mammary glands. This factor has very little effect on RNA metabolism.
D000818:Animals; D002286:Carcinoma, Ehrlich Tumor / Q000378:metabolism; D002417:Cattle; D002478:Cells, Cultured; D002642:Chick Embryo; D004261:DNA Replication / Q000187:drug effects*; D005260:Female; D006367:HeLa Cells / Q000378:metabolism; D008321:Mammary Glands, Animal / Q000378:metabolism*; D008325:Mammary Neoplasms, Experimental / Q000378:metabolism*; D009963:Orotic Acid / Q000378:metabolism; D012313:RNA / Q000378:metabolism; D013942:Thymine Nucleotides / Q000378:metabolism*
D013942:Thymine Nucleotides; D009963:Orotic Acid; D012313:RNA