Construction of a double-stranded deoxyribonucleotide sequence of 45 base pairs designed to code for S-peptide 2-14 of bovine ribonuclease A.
An artificial DNA duplex, each strand consisting of 45 monomers, is constructed from chemically synthesized deoxyriboöligonucleotides. The resulting bihelical polymer may code for a modified S-peptide of Ribonuclease A. This is the first synthetic duplex designed to code for a eukaryotic message.
D003090:Coliphages / Q000201:enzymology; D004247:DNA / Q000138:chemical synthesis*; D005815:Genetic Code; D008722:Methods; D010446:Peptide Fragments; D011118:Polynucleotide Ligases; D012260:Ribonucleases / Q000096:biosynthesis / Q000235:genetics*
D010446:Peptide Fragments; D004247:DNA; D012260:Ribonucleases; D011118:Polynucleotide Ligases