The role of sodium retention in Goldblatt 2-kidney hypertension in the rat.
1. Infusion of angiotensin II antagonist failed to restore the blood pressure of short-term Goldblatt 2-kidney hypertensive rats to normal levels before and after sodium restriction. 2. The blood pressure of both normal and sodium-restricted Goldblatt 2 hypertensive rats remained elevated 6 h after bilateral nephrectomy. 3. The residual hypertension found during antagonist infusion and after bilateral nephrectomy is not maintained by the renin-angiotensin system or sodium retention.
D000804:Angiotensin II / Q000031:analogs & derivatives*; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D005260:Female; D006973:Hypertension / Q000209:etiology*; D009392:Nephrectomy; D051381:Rats; D012504:Saralasin / Q000494:pharmacology*; D012964:Sodium / Q000172:deficiency*
D000804:Angiotensin II; D012964:Sodium; D012504:Saralasin