beta-receptor-blockade hypotension and the central nervous system.
1. Intravenous infusion of propranolol (3-86 micronmol h-1 kg-1) for 2 h lowered arterial pressure in the conscious rabbit whereas similar infusions of practolol (37-6 micronmol h-1 kg-1) did not. 2. The fall in blood pressure produced by propranolol was accompanied by a decrease in splanchnic nerve activity. Practolol did not change splanchnic nerve activity. 3. A centrally mediated decrease in sympathetic nervous activity makes an important contribution to the hypotensive action of propranolol in the rabbit. This effect is not shown by practolol.
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects*; D003864:Depression, Chemical; D011217:Practolol / Q000494:pharmacology; D011433:Propranolol / Q000494:pharmacology*; D011817:Rabbits; D013153:Splanchnic Nerves / Q000187:drug effects
D011433:Propranolol; D011217:Practolol