Total devascularization of the Liver: an experimental model of acute liver failure.
An experimental model of clinical liver failure, using total devascularization of the liver is described in the pit. The survival time was 1495 +/- 75 (SEM) minutes. Clinically the pigs showed a uniform course. They became lethargic after eight to ten hours and following a period of increasing drowsiness they became comatose. The immediate cause of death was cardio-vasculary collaps. The ammonium ion concentration in the blood increased to 696 +/- 57 umol/l and in cerebrospinal fluid to 664 +/- 57 umol/l. Cerebrospinal fluid glucose concentration was significantly decreased.
D000208:Acute Disease; D000641:Ammonia / Q000134:cerebrospinal fluid; D000818:Animals; D004195:Disease Models, Animal; D005947:Glucose / Q000134:cerebrospinal fluid; D007773:Lactates / Q000134:cerebrospinal fluid; D008099:Liver / Q000098:blood supply*; D008107:Liver Diseases / Q000134:cerebrospinal fluid / Q000209:etiology* / Q000378:metabolism; D011188:Potassium / Q000134:cerebrospinal fluid; D012964:Sodium / Q000134:cerebrospinal fluid; D013552:Swine
D007773:Lactates; D000641:Ammonia; D012964:Sodium; D005947:Glucose; D011188:Potassium