title: [The treatment of acute myelocytic leukemia during the first recurrence by means of a new cytostatic combination].
abstract: Fifteen patients with acute myeloic leukemia in the first relapse following initial therapy were treated with a combination of adriamycin, vincristine, 6-thioguanine and the new podophyllotoxin derivative VP 16-213. Complete remission was obtained in 3 cases and partial remission in 3 further patients. The combination was generally well tolerated. These preliminary results are compared with those available in the relatively meagre literature. The study is being continued.
mesh_terms: D003561:Cytarabine / Q000627:therapeutic use; D003630:Daunorubicin / Q000627:therapeutic use; D004317:Doxorubicin / Q000627:therapeutic use*; D004359:Drug Therapy, Combination; D005047:Etoposide / Q000627:therapeutic use*; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000188:drug therapy*; D011034:Podophyllotoxin / Q000031:analogs & derivatives*; D013866:Thioguanine / Q000627:therapeutic use*; D014750:Vincristine / Q000627:therapeutic use*
chemical_list: D003561:Cytarabine; D014750:Vincristine; D005047:Etoposide; D004317:Doxorubicin; D013866:Thioguanine; D011034:Podophyllotoxin; D003630:Daunorubicin
vernacular_title: Die Behandlung der akuten myeloischen Leukämie im ersten Rückfall mit einer neuartigen zytostatischen Kombination