title: In vitro studies of bone resorption by the root-resorbing tissue from the bovine deciduous tooth.
abstract: Granulation tissue which is responsible for root resorption of deciduous tooth lies between root of the deciduous tooth and its permanent tooth germ. This tissue is called "root-resorbing tissue". Its bone-resorbing activity was investigated in vitro. Bovine root-resorbing tissue was cultured in close contact with 45Ca-labeled dead calvaria of rats. Bone-resorbing activity was determined by measuring 45Ca released from labeled calvaria during culture. It was found that only the root-resorbing tissue which was rich in odontoclasts and had a good blood supply in its surface layer had bone-resorbing ability, and that bone resorption occurred only when it was placed in close contact with calvarium. The root-resorbing tissue which was poor in odontoclasts and blood vessels failed to stimulate by 25-hydroxy-vitaim D3 or heparin, but not by larger amounts of parathyroid hormone, vitamin D3, and dihydrotachysterol when added to the culture.
mesh_terms: D000539:Alveolar Process / Q000033:anatomy & histology / Q000502:physiology; D000818:Animals; D001862:Bone Resorption / Q000503:physiopathology*; D002417:Cattle; D006097:Granulation Tissue / Q000033:anatomy & histology / Q000502:physiology*; D008297:Male; D010281:Parathyroid Hormone / Q000502:physiology; D051381:Rats; D012391:Root Resorption / Q000503:physiopathology*; D014094:Tooth, Deciduous / Q000033:anatomy & histology / Q000502:physiology*; D014807:Vitamin D / Q000031:analogs & derivatives / Q000502:physiology
chemical_list: D010281:Parathyroid Hormone; D014807:Vitamin D