Does the renin-angiotensin system contribute to the vascular lesions in renal hypertensive rats?
1. Renal hypertensive rats with a normal or suppressed activity of the renin-angiotensin system develop vascular lesions which are similar to those observed in spontaneously hypertensive rats on high sodium diet. 2. Exposure of a vascular bed to high blood pressure results in a rapid damage of the vascular wall, irrespective of the state of the renin-angiotensin system.
D000804:Angiotensin II / Q000502:physiology*; D000818:Animals; D002561:Cerebrovascular Disorders / Q000209:etiology; D006977:Hypertension, Renal / Q000150:complications / Q000503:physiopathology*; D051381:Rats; D012077:Renal Artery / Q000473:pathology; D012083:Renin / Q000502:physiology*; D012964:Sodium / Q000502:physiology; D014652:Vascular Diseases / Q000209:etiology
D000804:Angiotensin II; D012964:Sodium; D012083:Renin