Emotional response to intravenous delta9tetrahydrocannabinol during oral surgery.
The administration of delta9THC intravenously as a premedicant to oral surgery resulted in acute pronounced elevations in anxiety states, a predominance of dysphoria over euphoria, and varying degrees of psychotic-like paranoiac thought. Neural effects that appeared to promote these effects included distortions of perception with sensory delusions, and heightened sensory receptiveness including antalgesic impressions of surgery; autonomic and visceral arousal greater than control or placebo levels; lack of overt behavioral signals of distress due to depersonalization; and time disintegration leading to fear-inducing misinformation about real surgical events. Introverted subjects who generally were inclined to rely on drug solutions to their problems tended to respond poorly to surgical pain and anxiety with delta9THC. These results, obtained from subjects considered to  have levels of presurgical apprehension that were average or below average, suggest that the environment in which high doses of cannabinols are experienced is a potent factor in determining the quality of the emotional response. A surgical environment containing even the mild stress of outpatient oral surgery appears to have the potential to precipitate undesirable emotional responses among cannabinol-intoxicated patients. There is continued high-level social use of cannabinols inour society, with an estimate of 40% to 55% among the college-age group seen frequently by oral surgeons. Results of this study suggest that clinicians should be prepared to detect the subtle signs of marijuana intoxication to protect their patients from further psychophysiologic complications during surgery.
D000293:Adolescent; D000328:Adult; D001007:Anxiety; D002188:Cannabis / Q000494:pharmacology*; D003975:Diazepam / Q000494:pharmacology; D013759:Dronabinol / Q000008:administration & dosage / Q000494:pharmacology*; D004644:Emotions / Q000187:drug effects*; D006624:Hippocampus / Q000187:drug effects; D006801:Humans; D007275:Injections, Intravenous; D008297:Male; D009055:Mouth / Q000601:surgery*; D010146:Pain / Q000503:physiopathology; D010919:Placebos; D011581:Psychological Tests; D011605:Psychoses, Substance-Induced / Q000209:etiology; D012189:Retrospective Studies; D012688:Septum Pellucidum / Q000187:drug effects; D013997:Time Factors
D010919:Placebos; D013759:Dronabinol; D003975:Diazepam