Effect of repeated bloodletting on the incidence of 2,7-FAA-induced rat leukemia.
The oral administration of N,N'-2,7-fuorenylenebisacetamide (2,7-FAA) induced leukemia, especially mature granulocytic leukemia, in rats. 2,7-FAA was administered to the rats of the Wistar strain and a small amount of bloodletting was repeated for a long period. The incidence of leukemia and mature granulocytic leukemia became elevated by bloodletting. The induction of mature granulocytic leukemia might be increased by the promotion of granulopoiesis which had been suppressed by 2,7-FAA.
D015073:2-Acetylaminofluorene / Q000031:analogs & derivatives*; D000818:Animals; D001815:Bloodletting; D005260:Female; D005449:Fluorenes; D006410:Hematopoiesis; D007942:Leukemia, Experimental / Q000139:chemically induced; D007951:Leukemia, Myeloid / Q000097:blood / Q000139:chemically induced*; D051381:Rats
D005449:Fluorenes; D015073:2-Acetylaminofluorene