The heterogeneity of leukemic reticuloendotheliosis, "hairy cell leukemia". Evidence for its monocytic origin.
The presence of B, T, and monocyte markers were studied on the spleen and peripheral blood mononuclear cells from two patients with leukemic reticuloendotheliosis. A high proportion of cells from both patients bore a receptor for cytophilic antibody, both in suspension and frozen tissue section. Cells in suspension lacked surface immunoglobulins or a receptor for sheep red blood cells. These results favor the evidence that "hairy cells" are monocytic in origin.
D000818:Animals; D000918:Antibody Specificity; D001666:Binding Sites, Antibody; D003165:Complement System Proteins / Q000032:analysis; D005260:Female; D006801:Humans; D007938:Leukemia / Q000473:pathology*; D007951:Leukemia, Myeloid / Q000209:etiology / Q000473:pathology; D008206:Lymphatic Diseases / Q000473:pathology*; D008214:Lymphocytes / Q000276:immunology; D008297:Male; D008875:Middle Aged; D009000:Monocytes / Q000276:immunology; D012157:Mononuclear Phagocyte System / Q000473:pathology; D013154:Spleen / Q000473:pathology
D003165:Complement System Proteins