[Association of monoclonal gammopathy with chronic glomerulonephritis and autoimmune hyperlipemia. Course of disease during therapy].
A case of benign monoclonal gammapathy associated with an auto-immune hyperlipidaemia and a chronic glomerulopathy is reported. Extraction of the monoclonal immunoglobulin made it possible to demonstrate its anti-lipoprotein antibody activity. Parallel changes in serum lipid levels and monoclonal immunoglobulin levels under the influence of melphalan confirmed the direction relationship between the lipid and protein disorders. The pathogenesis of the glomerulopathy and of the massive and prolonged activation of the classical complement pathway is more difficult to affirm. It is nevertheless possible that the renal involvement is due to an auto-immune complex disease.
D000328:Adult; D001327:Autoimmune Diseases; D002908:Chronic Disease; D005921:Glomerulonephritis / Q000188:drug therapy / Q000276:immunology*; D006801:Humans; D006942:Hypergammaglobulinemia / Q000188:drug therapy / Q000276:immunology*; D006949:Hyperlipidemias / Q000188:drug therapy / Q000276:immunology*; D007074:Immunoglobulin G / Q000032:analysis; D008297:Male; D009404:Nephrotic Syndrome / Q000276:immunology*
D007074:Immunoglobulin G
Association d'une gammapathie monoclonale, d'une glomérulopathie chronique et d'une hyperlipidémie auto-immune. evolution sous traitement