title: Fibrous lesions of the skin and mucous membranes which contain stellate and multinucleated cells.
abstract: Various fibrous lesions of the skin and mucous membranes share the common histologic feature of stellate and multinucleated fibroblasts. These cells are conspicuous under the light microscope because they contain a well-developed, rough endoplasmic reticulum which, because of its high RNA content, stains basophilic. These characteristic cells are a nearly constant feature of the retrocuspid papilla. They are apparent in about half of the fibrous papules of the nose and abundant in about 1 per cent of irritation fibromas. These lesions most likely represent a nonspecific proliferation of the lamina propria or papillary dermis to various stimuli.
mesh_terms: D000293:Adolescent; D000328:Adult; D002467:Cell Nucleus / Q000648:ultrastructure; D002648:Child; D002675:Child, Preschool; D003094:Collagen / Q000032:analysis; D004721:Endoplasmic Reticulum / Q000648:ultrastructure; D005260:Female; D005347:Fibroblasts / Q000473:pathology / Q000648:ultrastructure; D005350:Fibroma / Q000473:pathology*; D005887:Gingival Neoplasms / Q000473:pathology; D006801:Humans; D008247:Lysosomes / Q000648:ultrastructure; D008297:Male; D008875:Middle Aged; D008928:Mitochondria / Q000648:ultrastructure; D009061:Mouth Mucosa / Q000473:pathology*; D009062:Mouth Neoplasms / Q000473:pathology*; D009669:Nose Neoplasms / Q000473:pathology; D012878:Skin Neoplasms / Q000473:pathology*
chemical_list: D003094:Collagen