Ferritin phenotypes: structure and metabolism.
Recent advances in our understanding of the biochemistry of ferritin have provided new insights into its role in iron metabolism. Findings of multiple structural forms in many tissues may have important consequences for ferritin's function and metabolism. This article reviews the molecular basis of apoferritin heterogeneity and discusses mechanisms operating in the phenotypic expression of ferritin in normal and malignant cells.
D000596:Amino Acids / Q000032:analysis; D000818:Animals; D001059:Apoproteins / Q000378:metabolism; D005293:Ferritins / Q000097:blood / Q000378:metabolism; D006736:Horses; D006801:Humans; D007501:Iron / Q000378:metabolism; D007526:Isoelectric Point; D009369:Neoplasms / Q000378:metabolism; D011487:Protein Conformation; D051381:Rats
D000596:Amino Acids; D001059:Apoproteins; D005293:Ferritins; D007501:Iron