Definitive evidence that the murine C-type virus inducing locus Akv-1 is viral genetic material.
DNA of the AKR mouse contains a set of murine leukemia virus sequences that are not present in DNA of the NIH Swiss mouse. NIH mice partially congenic for the AKR murine-leukemia-virus-inducing locus Akv-1 contain this set of sequences, and, in a three-point cross segregating for Akv-1 on an NIH background, the sequences segregated with Akv-1. It is concluded that the Akv-1 locus contains viral sequences.
D000406:AKR murine leukemia virus / Q000254:growth & development; D000818:Animals; D001483:Base Sequence; D003433:Crosses, Genetic; D004247:DNA / Q000032:analysis*; D004279:DNA, Viral / Q000032:analysis*; D005796:Genes; D005838:Genotype; D007065:Idoxuridine / Q000494:pharmacology; D051379:Mice; D008806:Mice, Inbred AKR; D009693:Nucleic Acid Hybridization; D013045:Species Specificity
D004279:DNA, Viral; D004247:DNA; D007065:Idoxuridine