Analysis of multiple viral genome fragments in adenovirus 7-transformed hamster cells.
The presence of multiple copies of a portion of the viral genome was demonstrated in Ad7-transformed cells by a new method based on the kinetic analysis of labeled viral DNA reassociation in the presence of unlabeled transformed cell DNA. DNA-DNA homology measurement utilizing defined DNA fragments (restriction endonuclease digests) as labeled probes supported the above conclusion.
D000256:Adenoviridae / Q000032:analysis*; D002460:Cell Line; D002471:Cell Transformation, Neoplastic; D002875:Chromosomes / Q000032:analysis*; D004262:DNA Restriction Enzymes; D004279:DNA, Viral / Q000032:analysis*; D007700:Kinetics; D008954:Models, Biological; D008970:Molecular Weight; D009693:Nucleic Acid Hybridization
D004279:DNA, Viral; D004262:DNA Restriction Enzymes