title: The role of metal ions in the activation of arginase.
abstract: The role of metal ions as activators of arginase hydrolyzing arginine were studied. The metal ion is assumed to form a complex with arginine and to promote the enzymatic reaction. The activating ability of the metal ion appears to be governed by the chelating ability and/or the coordination numbers which determine whether the metal ion combines with the enzyme or the substrate (or both substrate and enzyme) and factors which influence the configuration of the resulting complexes.
mesh_terms: D000818:Animals; D001119:Arginase / Q000378:metabolism*; D002417:Cattle; D004789:Enzyme Activation; D007700:Kinetics; D008099:Liver / Q000201:enzymology; D008670:Metals / Q000494:pharmacology*
chemical_list: D008670:Metals; D001119:Arginase