title: Inhibition of erythrocyte phosphate transport by high pressures.
abstract: Pressures of 200-1000 atmospheres (20-100 MPa) are found to decrease significantly the amount of phosphate (H32PO4-2)transported into the rabbit erythrocyte under otherwise physiological conditions. Such compression does not cause irreversible morphological changes or result in membrane disruption. The findings are interpreted in terms of a lipid phase transition induced by the high pressure, which is propagated to the associated phosphate transport system by a physical mechanism.
mesh_terms: D000818:Animals; D001274:Atmospheric Pressure; D001692:Biological Transport; D002462:Cell Membrane / Q000378:metabolism; D004912:Erythrocytes / Q000378:metabolism* / Q000648:ultrastructure; D008297:Male; D010710:Phosphates / Q000097:blood*; D011817:Rabbits
chemical_list: D010710:Phosphates