Biological and immunological studies of a placental gonadotropic protein.
Precocious sexual maturity, ovarian weight increase and stimulation of the sex accessory organs in impuber female mice, was induced by a partially purified protein fraction obtained from human placenta. The relationship between this biologically active protein and HCG was studied by a comparative immuno-double diffusion technique (Ouchterlony) and two agglutination inhibition tests. Results showed that this protein with gonadotropic activity is neither immunologically related to HCG nor contaminated with this hormone.
D000818:Animals; D055598:Chemical Phenomena; D002621:Chemistry; D005260:Female; D005836:Genitalia, Female / Q000187:drug effects*; D006801:Humans; D051379:Mice; D010926:Placental Hormones / Q000494:pharmacology*; D011247:Pregnancy
D010926:Placental Hormones