title: Vasoactivity of local anaesthetic solutions.
abstract: The basic mechanisms responsible for effects of vasoconstrictors in local anaesthetic solutions are not fully understood. In this paper the interactions of the various ingredients of local anesthetic solutions are considered. Some of the author's work in this field is summarised and current research is discussed.
mesh_terms: D000779:Anesthetics, Local / Q000494:pharmacology*; D000818:Animals; D001158:Arteries / Q000187:drug effects; D001808:Blood Vessels / Q000187:drug effects* / Q000294:innervation; D002395:Catecholamines / Q000378:metabolism; D004357:Drug Synergism; D006801:Humans; D009130:Muscle, Smooth / Q000294:innervation; D009638:Norepinephrine / Q000494:pharmacology; D011817:Rabbits; D013564:Sympathetic Nervous System / Q000378:metabolism; D014662:Vasoconstrictor Agents / Q000494:pharmacology; D014680:Veins / Q000187:drug effects
chemical_list: D000779:Anesthetics, Local; D002395:Catecholamines; D014662:Vasoconstrictor Agents; D009638:Norepinephrine