Studies on hypoxia: XII. Detrimental effects of synthetic polyribonucleotides on epiphyseal plates of rats exposed to hypoxia.
The effect of different doses of polyadenylic and polyuridylic acids (poly A:U) was studied in control rats and in rats exposed to hypoxia. In the control rats, administration of different doses of poly A:U did not change the thickness of the epiphyseal plate or increase the incorporation of 3H-phenylalanine as judged using radioautography. Rats exposed to hypoxia showed a significant dose-related reduction in the thickness of the epiphyseal plate and 3H-phenylalanine incorporation.
D000596:Amino Acids / Q000378:metabolism; D000818:Animals; D003238:Connective Tissue / Q000187:drug effects / Q000378:metabolism; D004305:Dose-Response Relationship, Drug; D004838:Epiphyses / Q000187:drug effects* / Q000378:metabolism / Q000473:pathology; D000860:Hypoxia / Q000378:metabolism* / Q000473:pathology; D008297:Male; D011061:Poly A / Q000008:administration & dosage / Q000138:chemical synthesis / Q000494:pharmacology*; D011072:Poly U / Q000008:administration & dosage / Q000138:chemical synthesis / Q000494:pharmacology*; D051381:Rats
D000596:Amino Acids; D011061:Poly A; D011072:Poly U