title: A chlorhexidine-containing methacrylic gel as a periodontal dressing.
abstract: The modification of a methacrylic gel for use as a periodontal dressing was attempted. The increased adhesion and rigidity of the resultant material appeared consistent with the clinical findings. Satisfactory retention of the dressing was found in 85% of those placed on a group of patients attending for periodontal surgery. The potential value of the methacrylic gel for carrying and releasing pharmacological agents useful in the management of lesions of the oral mucosa was assessed by incorporating chlorhexidine acetate into the dressing. In vitro and in vivo studies demonstrated effective release of the chlorhexidine from the dressing throughout the period of time a periodontal dressing is normally in situ. In conclusion the results suggested that the modified methacrylic gel fulfills the requirements of a periodontal dressing. Study to assess further the potential for this material to carry other pharmacological agents used in the topical treatment of lesions of the oral mucosa is indicated.
mesh_terms: D000179:Acrylates / Q000627:therapeutic use*; D001419:Bacteria / Q000187:drug effects; D001645:Biguanides / Q000627:therapeutic use*; D002710:Chlorhexidine / Q000494:pharmacology / Q000627:therapeutic use*; D005782:Gels; D006801:Humans; D008689:Methacrylates / Q000627:therapeutic use*; D010511:Periodontal Dressings
chemical_list: D000179:Acrylates; D001645:Biguanides; D005782:Gels; D008689:Methacrylates; D002710:Chlorhexidine