The erythrocytic line in refractory anemia (preleukemia or hemopoietic dysplasia) and myelomonocytic leukemia. II. Some unusual morphologic variants of the polychromatic normoblasts and reticulocytes.
In a combined scanning and transmission electron microscopic study of the red blood cell line in patients with refractory anemia (preleukemia) and myelomonocytic leukemia, certain elements with abundant, convoluted membranes that formed projections over the cell surface were observed. These cells were both normoblasts (nucleated) and reticulocytes (anucleated) and constituted what appeared to be a distinct subpopulation of the red blood cell line. It is possible that in these erythrocytes there is a nucleocytoplasmic asynchronism. We are not certain, however, that they are linked to the leukemic process.
D000741:Anemia, Aplastic / Q000097:blood*; D004912:Erythrocytes / Q000648:ultrastructure*; D004913:Erythrocytes, Abnormal; D006801:Humans; D007951:Leukemia, Myeloid / Q000097:blood*