title: Effects of sympatho-adrenal activity and pharmacological treatment on gastrointestinal propulsion in the early postoperative period. An experimental study in the laparotomized rat.
abstract: Gastric evacuation and small bowel propulsion were greatly retarded two hours after laparotomy in the rat. Adrenal demedullation, chemical sympathectomy with 6-hydroxydopamine or treatment with a cholinesterase inhibitor (Neostigmin), an alpha-receptor blocker (Dibenyline) or metoclopramide (Primperan) did not improve the gastric evacuation. Chemical sympathectomy or treatment with metoclopramide, however, significantly improved small bowel propulsion. A significant reflux of duodenal contents to the stomach was found in several animals treated with the cholinesterase inhibitor or subjected to adrenal demedullation.
mesh_terms: D000005:Abdomen / Q000601:surgery*; D000313:Adrenal Medulla / Q000502:physiology; D000818:Animals; D005769:Gastrointestinal Motility; D006892:Hydroxydopamines / Q000494:pharmacology; D007421:Intestine, Small / Q000502:physiology; D008297:Male; D008787:Metoclopramide / Q000494:pharmacology; D009388:Neostigmine / Q000494:pharmacology; D010643:Phenoxybenzamine / Q000494:pharmacology; D051381:Rats; D011941:Receptors, Adrenergic / Q000187:drug effects*; D013270:Stomach / Q000502:physiology; D013564:Sympathetic Nervous System / Q000187:drug effects
chemical_list: D006892:Hydroxydopamines; D011941:Receptors, Adrenergic; D010643:Phenoxybenzamine; D009388:Neostigmine; D008787:Metoclopramide