Quantitative studies of in vitro inhibition of Streptococcus mutans plaque formation by organic amines.
The abilities of five, long-chain aliphatic monamines to inhibit the deposition of plaque formed by Streptococcus mutans on stainless-steel wires were determined. The compounds along with their relative inhibitory potencies that were studied are N-methyltetradecylamine, hexadecylamine, dodecylamine, N-ethyldodecylamine, and octylamine. Activities are compared with critical micelle concentrations, partition coefficients, and quantum mechanical charges on the amine nitrogens.
D000588:Amines / Q000032:analysis / Q000494:pharmacology*; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D003773:Dental Plaque / Q000378:metabolism* / Q000382:microbiology; D004305:Dose-Response Relationship, Drug; D006801:Humans; D008823:Micelles / Q000032:analysis; D013291:Streptococcus / Q000378:metabolism*; D013295:Streptococcus mutans / Q000378:metabolism*
D000588:Amines; D008823:Micelles