title: [Therapy of consumption coagulopathy and hyperfibrinolysis with urokinase in a case of acute promyelocytic leukemia].
abstract: A case report is presented of a 20 year old patient with an acute promyelocytic leukemia. The presenting symptom was a macrohematuria caused by a consumption coagulopathy. Consumption coagulopathy has only been observed in acute promyelocytic leukemia in contrast to other coagulopathies in acute leukemia. The clotting disorder was successfully treated by administration of urokinase.
mesh_terms: D000208:Acute Disease; D000328:Adult; D000970:Antineoplastic Agents / Q000627:therapeutic use; D001853:Bone Marrow / Q000473:pathology; D003937:Diagnosis, Differential; D004211:Disseminated Intravascular Coagulation / Q000175:diagnosis / Q000188:drug therapy* / Q000209:etiology; D010450:Endopeptidases / Q000627:therapeutic use*; D005343:Fibrinolytic Agents / Q000627:therapeutic use; D006417:Hematuria; D006801:Humans; D007951:Leukemia, Myeloid / Q000150:complications* / Q000175:diagnosis; D008297:Male; D011379:Prognosis; D014568:Urokinase-Type Plasminogen Activator / Q000627:therapeutic use*
chemical_list: D000970:Antineoplastic Agents; D005343:Fibrinolytic Agents; D010450:Endopeptidases; D014568:Urokinase-Type Plasminogen Activator
vernacular_title: Urokinasetherapie der Verbrauchskoagulopathie und Hyperfibrinolyse bei akuter Promyelozytenleukämie