Stimulation of prostaglandin E synthesis in cultured human umbilical vein smooth muscle cells.
Cultured human umbilical vein smooth muscle cells secreted 1.26 +/- 0.20 mug of immunoreactive prostaglandin E (iPGE) per mg of cell protein per 24 hr (mean +/- SEM). In indomethacin, an inhibitor of prostaglandin synthesis, abolished greater than 95% of this basal iPGE production (ID50 = 1.8 nM).
D000804:Angiotensin II / Q000494:pharmacology; D001920:Bradykinin / Q000494:pharmacology; D002478:Cells, Cultured; D006632:Histamine / Q000494:pharmacology; D007213:Indomethacin / Q000494:pharmacology; D009130:Muscle, Smooth / Q000187:drug effects / Q000378:metabolism*; D009638:Norepinephrine / Q000494:pharmacology; D011458:Prostaglandins E / Q000096:biosynthesis*; D012701:Serotonin / Q000494:pharmacology; D014471:Umbilical Veins
D011458:Prostaglandins E; D000804:Angiotensin II; D012701:Serotonin; D006632:Histamine; D001920:Bradykinin; D009638:Norepinephrine; D007213:Indomethacin