Polycythemia vera treated with -32p and myleran: development of chronic granulocytic leukemia with chromosomal abnormalities in one patient.
Chronic granulocytic leukemia developed in a 59-year-old woman who had previously received a total of 21 mCi -32P for polycythemia vera. She was treated with Myleran (busulphan) for her chronic granulocytic leukemia. Cytogenic studied revealed deletion of chromosomes No. 8 and 12, and translocation between 1 and 8. The patient also developed a severe antoimmune hemolytic anemia, for which she received prednisone treatment. She died with a perforated stomach ulcer.
D000744:Anemia, Hemolytic, Autoimmune / Q000188:drug therapy / Q000209:etiology; D002066:Busulfan / Q000627:therapeutic use*; D002900:Chromosomes, Human, 1-3; D002906:Chromosomes, Human, 6-12 and X; D002908:Chronic Disease; D005260:Female; D006801:Humans; D007621:Karyotyping; D007951:Leukemia, Myeloid / Q000139:chemically induced* / Q000188:drug therapy; D008875:Middle Aged; D010761:Phosphorus Radioisotopes / Q000627:therapeutic use*; D011087:Polycythemia Vera / Q000188:drug therapy*; D011241:Prednisone / Q000627:therapeutic use; D014178:Translocation, Genetic
D010761:Phosphorus Radioisotopes; D002066:Busulfan; D011241:Prednisone