[Eosinophilia in the preleukaemic phase of acute granulocytic leukaemia (author's transl)].
The pathogenesis of a marked eosinophilia in the preleukaemic phase of an acute granulocytic leukaemia is described and discussed. An otherwise symptom-free girl 4 years of age, presented with a transient increased WBC count with eosinophilia during one year before onset of acute granulocytic leukaemia. All relevant tests for explanation of this eosinophilia proved negative. The phenomenon of transient eosinophilia with successive onset of acute granulocytic leukaemia may fit into the concept of immunological control of tumorgenesis. In the present case it is suggested that the initial eosinophilia was the manifestation of the body's fight against the first malignant leukaemic cells. Finally the immunological defence was overwhelmed and the eosinophilia disappeared with concomitant appearance of leukaemic cells.
D000912:Antibodies, Neoplasm / Q000032:analysis; D001772:Blood Cell Count; D002675:Child, Preschool; D004802:Eosinophilia / Q000175:diagnosis / Q000209:etiology*; D005260:Female; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000032:analysis / Q000150:complications* / Q000175:diagnosis; D011230:Precancerous Conditions / Q000150:complications*
D000912:Antibodies, Neoplasm
Zur Frage einer Eosinophilie während der präleukämischen Phase einer akuten myeloischen Leukämie