Effects of cholera toxin on cochlear endolymph production: model for endolymphatic hydrops.
To evaluate a possible role for adenylate cyclase [ATP pyrophosphate-lyase (cyclizing), EC 4.6.1.1] and adenosine 3':5'-cyclic monophosphate in the secretion of endolymph, we studied the effect of an intra-scala media injection of purified cholera toxin (an adenylate cyclase stimulant) on cochlear endolymph volume, endolymphatic potential, and endolymphatic Na and K concentrations.
D000262:Adenylyl Cyclases / Q000378:metabolism; D000818:Animals; D001059:Apoproteins / Q000378:metabolism*; D002771:Cholera; D003051:Cochlea / Q000201:enzymology; D004487:Edema / Q000139:chemically induced; D004710:Endolymph / Q000378:metabolism / Q000502:physiology; D004789:Enzyme Activation / Q000187:drug effects; D006168:Guinea Pigs; D008074:Lipoproteins / Q000378:metabolism*; D011188:Potassium / Q000378:metabolism; D012964:Sodium / Q000378:metabolism; D013997:Time Factors
D001059:Apoproteins; D008074:Lipoproteins; D012964:Sodium; D000262:Adenylyl Cyclases; D011188:Potassium