[Assisted circulation. The effect of cardio-synchronous peripheral arterio-arterial counterpulsation on perfusion and metabolism in the area of acute transmural myocardial ischemia].
After establishing a model of ischemia, perfusion in the ischemic area was considerably disturbed. Examination by means of 133xenon-clearance after intramyocardiac injection showed strongly delayed flowing-off compared with controls. Counterpulsation accelerates the flowing-off (perfusion). Untreated control animals reveal after inducing the model ischemia a crucial decrease of ATP concentration and an excessive increase of lactate concentration in the ischemic area. Counterpulsation may inhibit further decrease of ATP in the ischemic area.
D000255:Adenosine Triphosphate / Q000378:metabolism; D000818:Animals; D001243:Assisted Circulation; D003327:Coronary Disease / Q000378:metabolism / Q000503:physiopathology*; D004195:Disease Models, Animal; D006801:Humans; D007423:Intra-Aortic Balloon Pumping; D007770:L-Lactate Dehydrogenase / Q000378:metabolism; D007773:Lactates / Q000378:metabolism; D008026:Ligation; D008657:Metabolic Clearance Rate; D009206:Myocardium / Q000378:metabolism; D010477:Perfusion; D010725:Phosphocreatine / Q000378:metabolism; D013997:Time Factors; D014980:Xenon Radioisotopes
D007773:Lactates; D014980:Xenon Radioisotopes; D010725:Phosphocreatine; D000255:Adenosine Triphosphate; D007770:L-Lactate Dehydrogenase
Zur assistierten Zirkulation - Die Wirkung der herzsynchronen peripheren arterio-arteriellen Gegenpulsation auf die Perfusions- und Stoffwechselsituation im akuten transmuralen myokardialen Ischämieareal.