The effect of high cervical cordotomy on portal vein plasma serotonin and 5-hydroxyindoleacetic acid levels in dogs with and without superior mesenteric artery occlusion.
In ten dogs undergoing high cervical cardotomy, there was a statistically significant fall in plasma serotonin (5-HT) levels in portal vein blood; no further change in plasma 5-HT occurred after superior mesenteric artery (SMA) occlusion, which is an effective stimulus for 5-HT release. In five dogs undergoing high cervical corotomy with no SMA occlusion, there was a comparable fall in portal vein plasma 5-HT levels. The 5-hydroxyindoleacetic acid (5-HIAA) values in portal vein blood in the two groups of dogs above fell to comparable levels. These findings  indicate (1) that maintenance of the normal plasma 5-HT level in portal vein blood in this experimental model is dependent on the integrity of the spinal cord and (2) that SMA occlusion in animals with a high cervical cordotomy does not result in further changes in the plasma 5-HT level in portal vein blood.
D000818:Animals; D002818:Cordotomy; D004195:Disease Models, Animal; D004285:Dogs; D006897:Hydroxyindoleacetic Acid / Q000097:blood / Q000378:metabolism*; D007421:Intestine, Small / Q000378:metabolism* / Q000503:physiopathology; D008638:Mesenteric Arteries; D008641:Mesenteric Vascular Occlusion / Q000503:physiopathology*; D011169:Portal Vein; D012701:Serotonin / Q000097:blood / Q000378:metabolism*; D013050:Spectrometry, Fluorescence; D013116:Spinal Cord / Q000502:physiology*; D013997:Time Factors
D012701:Serotonin; D006897:Hydroxyindoleacetic Acid