Treatment of busulfan-induced pancytopenia.
A patient with busulfan-induced pancytopenia and recurrent, thrombocytopenic bleeding was treated prophylactically with random-donor platelet transfusions and later with HLA-matched platelets from a sibling. The pancytopenia remitted after five months. The course and alternative modes of therapy of busulfan-induced pancytopenia are discussed. This disorder may be reversible if the patient can be supported through an initial period of severe pancytopenia.
D000328:Adult; D001772:Blood Cell Count; D001803:Blood Transfusion; D001856:Bone Marrow Examination; D002066:Busulfan / Q000008:administration & dosage / Q000009:adverse effects* / Q000627:therapeutic use; D004305:Dose-Response Relationship, Drug; D017707:Erythrocyte Transfusion; D006801:Humans; D007951:Leukemia, Myeloid / Q000188:drug therapy; D008297:Male; D017713:Platelet Transfusion
D002066:Busulfan