title: Erythropoietin activity in acutely uremic mice.
abstract: Erythropoietic activity produced by exogenous erythropoietin (Ep) is markedly reduced in Swiss mice rendered uremic by bilateral nephrectomy or bilateral ureteral ligation. Exogenous Ep causes a greater increase in erythropoiesis in germfree Swiss mice as compared with non-germfree mice, but the germfree mice show a more drastic reduction of erythropoiesis in uremia. Heme production in blood, spleen, and femoral marrow retains its typical pattern in uremia; there is no shift of erythropoiesis among the three sites. Production of endogenous Ep in uremic mice is less by a factor of 2-3 than that in intact mice whereas the reduction is by a factor of almost 100 in anephric mice. The data suggest that the anemia associated with uremia is the result of two phenomena: (1) a decreased production of Ep and (2) a diminished erythropoietic response to Ep.
mesh_terms: D000740:Anemia / Q000097:blood / Q000209:etiology; D000818:Animals; D004195:Disease Models, Animal; D004920:Erythropoiesis / Q000187:drug effects*; D004921:Erythropoietin / Q000096:biosynthesis / Q000494:pharmacology*; D005260:Female; D005856:Germ-Free Life; D007668:Kidney / Q000378:metabolism; D008297:Male; D051379:Mice; D009392:Nephrectomy; D014511:Uremia / Q000097:blood* / Q000378:metabolism
chemical_list: D004921:Erythropoietin