title: Nonrandom chromosomal abnormalities in hematologic disorders of man.
abstract: A nonrandom pattern of chromosomal abnormalities occurs in bone marrow cells obtained from patients with hematologic disorders who have an abnormal karyotype involving a C group chromosome. An additional number 8 chromosome is the most common abnormality, found in more than one-half of the patients studies. An additional number 9 chromosome and the loss of all or part of a number 7 are abnormalities that occur more often than might be expected by chance. It is proposed that specific human chromosomal abnormalities may be related to different specific etiologic agents.
mesh_terms: D000208:Acute Disease; D000756:Anemia, Sideroblastic / Q000235:genetics; D001854:Bone Marrow Cells; D002906:Chromosomes, Human, 6-12 and X; D006402:Hematologic Diseases / Q000235:genetics*; D006801:Humans; D007621:Karyotyping; D007938:Leukemia / Q000235:genetics; D007951:Leukemia, Myeloid / Q000235:genetics; D011087:Polycythemia Vera / Q000235:genetics; D014314:Trisomy