[Study of the L-transforming action on Brucella cells of tetracycline, streptomycin, rifampicin and their combinations with penicillin in in vitro experiments].
The in vitro study of the possible formation of L-forms of Brucella under the effect of tetracycline, streptomycin, rifampicin or their combinations with penicillin showed that passages of various Brucella species on media containing increasing concentrations of the antibiotics resulted in insignificant morphological changes in the cells. Passages of the same cultures on media containing combinations of the above antibiotics with penicillin resulted in more significant changes in the cell morphology, up to formation of spheroplasts. No L-transformation was observed under the experimental conditions.
D002002:Brucella / Q000187:drug effects*; D003470:Culture Media; D004338:Drug Combinations; D066298:In Vitro Techniques; D007740:L Forms / Q000187:drug effects*; D010400:Penicillin G / Q000494:pharmacology*; D010403:Penicillin Resistance; D012293:Rifampin / Q000494:pharmacology*; D013307:Streptomycin / Q000494:pharmacology*; D013752:Tetracycline / Q000494:pharmacology*
D003470:Culture Media; D004338:Drug Combinations; D013752:Tetracycline; D010400:Penicillin G; D012293:Rifampin; D013307:Streptomycin
Izuchenie L-transformiruiushchego deĭstviia na kletki brutsell tetratsiklina, streptomitsina, rifampitsina i ikh kombinatsiĭ s penitsillinom v opytakh in vitro