[Chronic myelogenous leukaemia as a possible consequence of immunosuppressive treatment of nephrotic syndrome (author's transl)].
A boy, aged 14, suffered since his 5th year from nephrotic syndrome. During the first 7 years he had been treated with adrenocorticosteroids, but his condition hardly improved. Then a cyclophosphamide treatment was started with a total dosis of 5 g in 50 days. The nephrotic syndrome had disappeared, but relapsed 3 years afterwards, this time accompanied by chronic myelogenous leukaemia. The possibility of the onset of chronic myelogenous leukaemia in connection with the immunosuppressive therapy (adrenocorticosteroids and cyclophosphamide) is discussed.
D000293:Adolescent; D000305:Adrenal Cortex Hormones / Q000009:adverse effects / Q000627:therapeutic use; D003520:Cyclophosphamide / Q000009:adverse effects / Q000627:therapeutic use; D006801:Humans; D007166:Immunosuppressive Agents / Q000009:adverse effects*; D007951:Leukemia, Myeloid / Q000139:chemically induced*; D008297:Male; D009404:Nephrotic Syndrome / Q000188:drug therapy*; D013997:Time Factors
D000305:Adrenal Cortex Hormones; D007166:Immunosuppressive Agents; D003520:Cyclophosphamide
Chronisch myeloische Leukämie als mögliche Folge immunsuppressiver Behandlung des nephrotischen Syndroms