title: Dopamine receptor binding in the corpus striatum of mammalian brain.
abstract: Specific binding of [3H]dopamine to membranes from the corpus striatum of rat and calf brain appears to involve the postsynaptic dopamine receptor. Specific [3H]dopamine binding is saturable, wnd with half-maximal binding in calf membranes at 7 nM. Apomorphine is about twice as potent as dopamine in competing for binding sites, whereas (-)norepinephrine is 5% as potent as dopamine and isoproterenol is virtually inactive. The relative potencies of phenothiazines as inhibitors of specific dopamine binding correlates with their clinical potencies and actions on the dopamine-sensitive adenylate cyclase.
mesh_terms: D000818:Animals; D001665:Binding Sites; D001667:Binding, Competitive; D002395:Catecholamines / Q000378:metabolism; D002417:Cattle; D003342:Corpus Striatum / Q000378:metabolism*; D004298:Dopamine / Q000378:metabolism*; D008297:Male; D010640:Phenothiazines / Q000378:metabolism; D051381:Rats; D011955:Receptors, Drug; D013329:Structure-Activity Relationship
chemical_list: D002395:Catecholamines; D010640:Phenothiazines; D011955:Receptors, Drug; D004298:Dopamine