Effects of short-term and long-term administration of procaine hydrochloride and mepivacaine hydrochloride on hexobarbital-induced sleeping times in mice.
Investigations were performed to determine the effects of short-and long-term pretreatment with procaine and mepivacaine on hexobarbital-induced sleeping times in mice. It was found that short-term preadministration with procaine (40 mg/kg) and mepivacine (40 and 60 mg/kg) significantly increased hexobarbital-induced sleeping time, but long-term pretreatment had no effect.
D000818:Animals; D004305:Dose-Response Relationship, Drug; D006591:Hexobarbital / Q000494:pharmacology*; D007274:Injections, Intraperitoneal; D008297:Male; D008619:Mepivacaine / Q000008:administration & dosage* / Q000494:pharmacology; D051379:Mice; D011343:Procaine / Q000008:administration & dosage* / Q000494:pharmacology; D012890:Sleep / Q000187:drug effects*; D013997:Time Factors
D011343:Procaine; D006591:Hexobarbital; D008619:Mepivacaine