title: Antistaphylococcal activity of sisomicin and four other aminoglycosides against strains sensitive and resistant to methicillin.
abstract: Five aminoglycosides were tested for inhibitory activity on 91 strains of Staphylococcus aureus, 39 of which were methicillin-resistant. The antistaphylococcal activity of these antibiotics was independent of the methicillin-resistance. Their order of decreasing effectiveness was: gentamicin greater than tobramycin = sisomicin greater than amikacin greater than kanamycin. Resistant strains were only found for the latter.
mesh_terms: D000617:Aminoglycosides / Q000494:pharmacology; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D008712:Methicillin / Q000494:pharmacology; D008826:Microbial Sensitivity Tests; D010403:Penicillin Resistance; D012853:Sisomicin / Q000494:pharmacology*; D013210:Staphylococcus / Q000187:drug effects*
chemical_list: D000617:Aminoglycosides; D000900:Anti-Bacterial Agents; D008712:Methicillin; D012853:Sisomicin