Restoration of immunocompetency by lymphocyte transfusion.
A female patient with metastatic osteosarcoma was given a lymphocyte transfusion from her brother, cured of the same histologic type of tumor ten years earlier. Prior to the transfusion the patient was anergic. Following lymphocyte transfer cutaneous reactivity to DNCB was restored. Skin reactivity to mumps and varidase antigens was specifically transferred. Whole lymphocyte transfer is a feasible method for restoring immune competence in the anergic cancer patient.
D000293:Adolescent; D000917:Antibody Formation; D000941:Antigens / Q000008:administration & dosage; D000956:Antigens, Viral / Q000008:administration & dosage; D001803:Blood Transfusion; D004137:Dinitrochlorobenzene; D005260:Female; D006801:Humans; D008214:Lymphocytes; D009109:Mumps virus; D012516:Osteosarcoma / Q000276:immunology*; D012882:Skin Tests; D013299:Streptodornase and Streptokinase
D000941:Antigens; D000956:Antigens, Viral; D004137:Dinitrochlorobenzene; D013299:Streptodornase and Streptokinase