Acute oral, dermal, and inhalation studies.
By appropriate testing procedures, it has been demonstrated that the compounds used as fluorescent whitening agents (FWAs) have a very low order of systemic toxicity in acute experiments. No evidence of dermal toxicity has been found. The full chemical names of the fluorescent whitening agents (FWAs) investigated in this study are listed below. They have been numbered for easy identification and classified by chemical groups.
D000284:Administration, Oral; D000287:Administration, Topical; D000336:Aerosols / Q000008:administration & dosage; D000818:Animals; D002415:Cats; D004396:Coloring Agents / Q000008:administration & dosage / Q000633:toxicity*; D004285:Dogs; D005123:Eye / Q000187:drug effects; D005260:Female; D006168:Guinea Pigs; D007509:Irritants / Q000494:pharmacology; D007928:Lethal Dose 50; D008297:Male; D051379:Mice; D011817:Rabbits; D051381:Rats; D012867:Skin / Q000187:drug effects
D000336:Aerosols; D004396:Coloring Agents; D007509:Irritants