title: [Combined radiotherapy and chemotherapy of the central nervous system in malignant neoplasms of children (author's transl)].
abstract: A combination of radiotherapy and cytostatic drugs was used in the treatment of 39 children with primary brain tumour between 1961 and 1974, and 40 children with acute lymphoid leukaemia between 1971 and 1974. Best results were obtained with medulloblastoma using cerebrospinal radiotherapy and cytostatic drugs: 10 of 17 children are still alive. Of 40 children with acute lymphoid leukaemia 18 are still alive after cerebrospinal or cranial radiotherapy. The side effects of the combined therapy were within justifiable limits.
mesh_terms: D000293:Adolescent; D001254:Astrocytoma / Q000188:drug therapy / Q000532:radiotherapy; D001932:Brain Neoplasms / Q000188:drug therapy / Q000532:radiotherapy / Q000628:therapy*; D001933:Brain Stem; D002648:Child; D002675:Child, Preschool; D003397:Craniopharyngioma / Q000188:drug therapy / Q000532:radiotherapy; D003520:Cyclophosphamide / Q000627:therapeutic use; D004806:Ependymoma / Q000188:drug therapy / Q000532:radiotherapy; D005260:Female; D006801:Humans; D007223:Infant; D007945:Leukemia, Lymphoid / Q000188:drug therapy / Q000532:radiotherapy / Q000628:therapy*; D008297:Male; D008527:Medulloblastoma / Q000188:drug therapy / Q000532:radiotherapy; D008727:Methotrexate / Q000627:therapeutic use; D011879:Radiotherapy Dosage; D014750:Vincristine / Q000627:therapeutic use
chemical_list: D014750:Vincristine; D003520:Cyclophosphamide; D008727:Methotrexate
vernacular_title: Kombinierte Radio-Chemotherapie des Zentralnervensystems bei malignen Neoplasien im Kindesalter