Friend leukemia: rapid development of erythropoietin-independent hematopoietic precursors.
Infection of mice with the polycythemia-inducing strain of Friend leukemia virus caused a rapid emergence of new erythroid precursor cells. These cells which, in the absence of erythropoietin, proliferated in vitro to form colonies and even differnetiated, quickly out-numbered the usual erythropoietin-dependent hematopoietic elements in bone marrow and spleen. Ultimately, the marrow and spleen were probably totally repopulated with this erythropoietin-independent cell.
D000818:Animals; D001853:Bone Marrow / Q000503:physiopathology; D002455:Cell Division; D004920:Erythropoiesis; D004921:Erythropoietin / Q000494:pharmacology*; D005260:Female; D005622:Friend murine leukemia virus; D004915:Leukemia, Erythroblastic, Acute / Q000503:physiopathology*; D007942:Leukemia, Experimental / Q000503:physiopathology; D008297:Male; D051379:Mice; D013154:Spleen / Q000503:physiopathology
D004921:Erythropoietin