Sarcoma arising in irradiated jawbones. Possible relationship with previous non-malignant bone lesions. Report of 6 cases and review of the literature.
Thirty-seven cases of radiation-induced sarcoma of the jaw are reviewed from the literature and six new cases are reported. It appears that irradiation seems to play a significant role in the development of jaw sarcoma: 10% of jaw sarcomas arise in irradiated bone. The initial lesion, however, that required irradiation appears to be equally important: 46% of the cases were found to have fibrous dysplasia as the initial lesion, whereas 18% of the remaining cases included diverse bone lesions. The bone was assumed to be normal in only 36% of the cases where irradiation was administered to adjacent tissue lesions. It seems that the association between irradiation and a pre-existing bone lesion has a definite oncologic effect.
D000293:Adolescent; D000328:Adult; D000368:Aged; D001859:Bone Neoplasms / Q000532:radiotherapy; D002648:Child; D005260:Female; D006801:Humans; D007573:Jaw Neoplasms / Q000209:etiology*; D008297:Male; D008875:Middle Aged; D009381:Neoplasms, Radiation-Induced; D011230:Precancerous Conditions / Q000532:radiotherapy; D011878:Radiotherapy / Q000009:adverse effects*; D012509:Sarcoma / Q000209:etiology*