Effects of iproniazid, chlorpromazine and methiothepin on DMT-induced changes in body temperature, pupillary dilatation, blood pressure and EEG in the rabbit.
The effects of i.v. N,N-dimethyltryptamine (DMT) were studied on arterial blood pressure, rectal temperature, pupil size and the electroencephalogram of the rabbit. DMT altered these parameters in a dose-related manner causing increased blood pressure, hyperthermia, pupilary mydriasis and activation of the electroencephalogram. Pretreatment with the monoamine oxidase inhibitor, iproniazid, prolonged the effects of DMT, while pretreatment with chlorpromazine or methiothepin attenuated these actions of DMT.
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects*; D001831:Body Temperature / Q000187:drug effects*; D002746:Chlorpromazine / Q000494:pharmacology*; D003864:Depression, Chemical; D003988:Dibenzothiepins / Q000494:pharmacology*; D004357:Drug Synergism; D004569:Electroencephalography; D007490:Iproniazid / Q000494:pharmacology*; D008297:Male; D004130:N,N-Dimethyltryptamine / Q000494:pharmacology*; D010879:Piperazines / Q000494:pharmacology; D011680:Pupil / Q000187:drug effects*; D011817:Rabbits; D013440:Sulfides / Q000494:pharmacology; D014363:Tryptamines / Q000494:pharmacology*
D003988:Dibenzothiepins; D010879:Piperazines; D013440:Sulfides; D014363:Tryptamines; D007490:Iproniazid; D002746:Chlorpromazine; D004130:N,N-Dimethyltryptamine