Effect of 13-Nle-motilin on small intestinal transit time in healthy subjects.
In 6 female subjects without gastrointestinal diseases, 13-norleucine motilin (13-Nle-M) synthetic and biological analogue of the duodenal polypeptide, motilin, caused acceleration of intestinal transit time. Intravenous infusion of 0.4 mug/kg-h of 13-Nle-M reduced mean transit time by 50 percent. No side effects occurred during infusion of the polypeptide. Radiographic appearance of small intestinal peristalsis and mucosal relief was not influenced by 13-Nle-M.
D005260:Female; D005768:Gastrointestinal Hormones / Q000494:pharmacology*; D005769:Gastrointestinal Motility / Q000187:drug effects*; D006801:Humans; D007421:Intestine, Small / Q000187:drug effects*; D008875:Middle Aged; D009037:Motilin / Q000031:analogs & derivatives / Q000494:pharmacology*; D013997:Time Factors
D005768:Gastrointestinal Hormones; D009037:Motilin