The penetration of doxycycline into CSF.
After single oral or intravenous doses of doxycycline the concentrations found in the spinal fluid did not exceed 0.1 mcg/ml. Daily oral administration for 2-10 days gave a level in the spinal fluid of 0.1-0.76 mcg/ml. The mean value, 0.37 mcg/ml, corresponded to 14% of the concentrations found in serum. Further studies of the penetration of doxycycline in patients with a damaged blood-brain barrier should be performed before doxycycline can be recommended for the treatment of CNS-infections.
D000284:Administration, Oral; D001812:Blood-Brain Barrier; D004318:Doxycycline / Q000008:administration & dosage / Q000134:cerebrospinal fluid*; D006801:Humans; D007275:Injections, Intravenous
D004318:Doxycycline