Absence of low-molecular-weight alpha crystallin in nuclear region of old human lenses.
Examination of old human lenses indicates that low-molecular-weight alpha crystallin is not present in the inner 30-40%, the nucleus, of the lens. The remainder of such lenses, the periphery, contains normal levels of this protein. This finding is in marked contrast to observations in young lenses, where a large quantity of this protein is found throughout the tissue.
D000375:Aging; D000596:Amino Acids / Q000032:analysis; D002386:Cataract / Q000378:metabolism*; D003459:Crystallins / Q000032:analysis / Q000378:metabolism*; D006801:Humans; D007908:Lens, Crystalline / Q000033:anatomy & histology / Q000378:metabolism*; D008970:Molecular Weight
D000596:Amino Acids; D003459:Crystallins