Acquired red cell pyruvate kinase deficiency in leukemias and related disorders.
The authors studied red blood cell pyruvate kinase activity of 202 patients with various hemopathies. A PK deficiency of moderate grade was found in 39% of patients with acute myeloblastic leukemias, in 57% of those with primary medullary insufficiency without aplasia, in 61% of those with refractory sideroblastic anemia. The PK deficiency was often associated with deficiencies of other red cell enzymes. The mechanism of such enzyme abnormalities was discussed with the hypothesis of a post-translational molecular alteration.
D000740:Anemia / Q000201:enzymology*; D000756:Anemia, Sideroblastic / Q000201:enzymology; D004798:Enzymes / Q000097:blood; D004912:Erythrocytes / Q000201:enzymology*; D006801:Humans; D007938:Leukemia / Q000201:enzymology*; D015470:Leukemia, Myeloid, Acute / Q000201:enzymology; D011770:Pyruvate Kinase / Q000097:blood / Q000172:deficiency*
D004798:Enzymes; D011770:Pyruvate Kinase