Reactivation of scabies rash by methotrexate.
A 13-year-old female was on maintenance therapy for acute lymphoblastic leukemia. On three occasions she received methotrexate orally and each time this was associated with reactivation of scabies rash. The mechanisms for this phenomenon are discussed.
D000293:Adolescent; D001593:Benzyl Compounds / Q000627:therapeutic use; D003561:Cytarabine / Q000627:therapeutic use; D005260:Female; D006801:Humans; D007945:Leukemia, Lymphoid / Q000150:complications / Q000188:drug therapy; D015122:Mercaptopurine / Q000627:therapeutic use; D008727:Methotrexate / Q000009:adverse effects* / Q000627:therapeutic use; D011239:Prednisolone / Q000627:therapeutic use; D012075:Remission, Spontaneous; D012532:Scabies / Q000139:chemically induced* / Q000188:drug therapy; D014750:Vincristine / Q000627:therapeutic use
D001593:Benzyl Compounds; D003561:Cytarabine; D014750:Vincristine; D011239:Prednisolone; D015122:Mercaptopurine; D008727:Methotrexate