Effect of selected dietary additives on the incidence of dental caries in the rat.
Weanling rats fed a cariogenic diet supplemented with carbamyl phosphate, in combination with egg shell meal and trace elements, showed a striking reduction in the incidence of caries. The cariostatic efficacy of carbamyl phosphate is significant because it stimulates fluid movement within odontoblasts via the hypothalamic-parotid gland endocrine axis.
D000818:Animals; D001216:Asparagine / Q000494:pharmacology; D001224:Aspartic Acid / Q000494:pharmacology; D002219:Carbamates / Q000494:pharmacology; D002221:Carbamyl Phosphate / Q000494:pharmacology; D002327:Cariostatic Agents / Q000494:pharmacology; D002857:Chromium / Q000494:pharmacology; D003485:Cyanates / Q000494:pharmacology; D003731:Dental Caries / Q000378:metabolism* / Q000382:microbiology; D004037:Diet, Cariogenic; D004528:Egg Shell; D005503:Food Additives / Q000494:pharmacology*; D006146:Guanidines / Q000494:pharmacology; D008297:Male; D008982:Molybdenum / Q000494:pharmacology; D051381:Rats; D013291:Streptococcus; D014131:Trace Elements / Q000494:pharmacology; D015032:Zinc / Q000494:pharmacology
D002219:Carbamates; D002327:Cariostatic Agents; D003485:Cyanates; D005503:Food Additives; D006146:Guanidines; D014131:Trace Elements; D002857:Chromium; D001224:Aspartic Acid; D002221:Carbamyl Phosphate; D001216:Asparagine; D008982:Molybdenum; D015032:Zinc