The antianabolic effect of tetracyclines in a consecutive clinical series.
In a series of 58 tetracycline-treated patients from an intensive care unit 33 patients were given oxytetracycline and 25 patients were given doxycycline. In 50 of the patients the serum creatinine level never exceeded 2 mg/100 ml. The serum urea/creatinine ratio was repeatedly determined in all patients. The oxytetracycline group displayed significantly higher mean values for this ratio during treatment than the doxycycline group. This was interpreted as a probable antianabolic effect due to the oxytetracycline therapy.
D003404:Creatinine / Q000097:blood*; D004318:Doxycycline / Q000494:pharmacology* / Q000627:therapeutic use; D006801:Humans; D008875:Middle Aged; D010118:Oxytetracycline / Q000494:pharmacology* / Q000627:therapeutic use; D013530:Surgical Wound Infection / Q000188:drug therapy / Q000517:prevention & control; D014508:Urea / Q000097:blood*
D014508:Urea; D003404:Creatinine; D004318:Doxycycline; D010118:Oxytetracycline