Ribonucleases in mouse ascitic tumor cells during ageing in vivo and in vitro.
Ribonuclease activities have been determined in cell extracts of mouse L5178Y lymphoma grown in vivo and in vitro. From the obtained results it follows that the level of studied enzymes changes in both systems during ageing of the cells. Moreover, when lymphoma cells are cultured in vitro a marked decrease in specific activity of alkaline ribonuclease II is observed.
D000375:Aging; D000818:Animals; D003585:Cell Biology; D002460:Cell Line; D002470:Cell Survival; D007942:Leukemia, Experimental; D007945:Leukemia, Lymphoid / Q000201:enzymology*; D051379:Mice; D012260:Ribonucleases / Q000378:metabolism*
D012260:Ribonucleases