Pharmacokinetic and pharmacological studies with clonidine in normal subjects.
1. A highly specific and sensitive assay based on stable isotope dilution and mass fragmentography has been developed to measure clonidine in plasma. 2. Plasma half-lives of clonidine ranged from 6-9 to 9-4 h in five normotensive subjects. 3. Plasma clonidine concentration correlated with reduction in salivary flow and degree of sedation but not with change in blood pressure.
D000328:Adult; D001794:Blood Pressure / Q000187:drug effects; D003000:Clonidine / Q000097:blood* / Q000494:pharmacology; D003864:Depression, Chemical; D006207:Half-Life; D006801:Humans; D008297:Male; D012463:Saliva / Q000378:metabolism
D003000:Clonidine