Protective effect of a mixture of radioprotector substances (mexamine and cystamine) on the haematopoietic stem cells of mice.
A protective effect of the mixture of radioprotectors (mexamine and cystamine) on the haematopoietic stem cells of the spleen and bone marrow was studied in mice irradiated by a dose 700 R in different time intervals after intraperitoneal injections of the substances. The protective effect of the mixture against the lethal radiation effects outlasts till the 90th minute after the injection, as well as the protection of the haematopoietic stem cells in the bone marrow. D0 of the regression lines of the survival of endogenous colonies in the spleen (ESC) increases up to 340 R after irradiating the mice in the 15 min interval after the injection of the protective substances with a subsequent decrease to the level of the control group (100 R). The D0 values of CFU survival in the bone marrow does not change; however, in the interval up to 60 min after the injection complete reparation of the radiation damage takes place after an exposure to 100 R. The recovery from the damage to the erythropoiesis followed by an incorporation of 59Fe into the bone marrow and spleen is the faster the higher a number of CFU survived the used radiation dose. The importance of a decrease of the radiation damage to the small intestine for the total protective effect of the mixture of radioprotectors is discussed.
D008735:5-Methoxytryptamine / Q000494:pharmacology; D000818:Animals; D003538:Cystamine / Q000494:pharmacology; D005260:Female; D006412:Hematopoietic Stem Cells / Q000187:drug effects / Q000528:radiation effects*; D007413:Intestinal Mucosa / Q000528:radiation effects; D051379:Mice; D011830:Radiation Effects; D011837:Radiation-Protective Agents; D013154:Spleen / Q000166:cytology
D011837:Radiation-Protective Agents; D008735:5-Methoxytryptamine; D003538:Cystamine