title: [Comparative study of the effectiveness of several antihypoxic agents and their combinations].
abstract: In 30--60 minutes following their administration sodium oxybutyrate in a dose of 100 mg/kg, mexamine in a dose of 2.5 and 5 mg/kg and also gutimine in doses of 25,50 and 100 mg/kg under conditions of hypoxic hypoxia corresponding to an altitude of 10000 m produce a marked antihypoxic effect. A combination of sodium oxybutyrate in the above dose, of mexamine in amounts of 1,2.5 and 5 mg/kg and also of gutimine in doses of 25,50 and 100 mg/kg permit it in some cases to achieve potentiation of antihypoxic effects of the drugs.
mesh_terms: D008735:5-Methoxytryptamine / Q000008:administration & dosage* / Q000627:therapeutic use; D000578:Amidines / Q000008:administration & dosage* / Q000627:therapeutic use; D000818:Animals; D004359:Drug Therapy, Combination; D006339:Heart Rate / Q000187:drug effects; D006885:Hydroxybutyrates / Q000008:administration & dosage* / Q000627:therapeutic use; D000860:Hypoxia / Q000188:drug therapy*; D008297:Male; D051379:Mice; D009200:Myocardial Contraction / Q000187:drug effects; D013268:Stimulation, Chemical; D013890:Thiourea / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000627:therapeutic use; D014363:Tryptamines / Q000008:administration & dosage*
chemical_list: D000578:Amidines; D006885:Hydroxybutyrates; D014363:Tryptamines; D008735:5-Methoxytryptamine; D013890:Thiourea
vernacular_title: Sravnitel'noe issledovanie éffektivnosti nekotorykh antigipoksantov i ikh kombinatsiĭ