Regulation of prostaglandin E2 biosynthesis in guinea pig skin by retinoic acid.
Topical application of retinoic acid on guinea pig skin resulted within 70 hours in erythema with a concomitant elevation of endogenous prostaglandin E2 (PGE2) in the treated areas of the skin. Prolonged daily treatment resulted in the development of severe scaly dermatoses and a corresponding decrease in the level of PGE2 in the skin. Examination of retinoic acid effects on the in vitro biosynthesis of PGE2 from arachidonic acid by extracts from guinea pig skin and sheep vesicular gland demonstrated that retinoic acid inhibits prostaglandin synthesis in concentration and time-dependent manner. These results indicate that retinoic acid may exert a regulatory role on prostaglandin biosynthesis in the skin.
D000818:Animals; D003864:Depression, Chemical; D005227:Fatty Acids / Q000378:metabolism; D006168:Guinea Pigs; D011458:Prostaglandins E / Q000096:biosynthesis*; D012756:Sheep; D012867:Skin / Q000187:drug effects / Q000201:enzymology / Q000378:metabolism*; D014212:Tretinoin / Q000494:pharmacology*; D014801:Vitamin A / Q000031:analogs & derivatives*
D005227:Fatty Acids; D011458:Prostaglandins E; D014801:Vitamin A; D014212:Tretinoin