A search for the factors responsible for absence of recovery of the normal vascular response to oxytocin following sympathetic nerve injury.
In dogs following crush injury to the lumbar sympathetic trunk, reflex vasoconstriction reappears in 4-6 months but the normal vasodilator response to oxytocin does not return even 12 months after crush. Histochemical examination of the walls of the blood vessels shows that division or crush of the lumbar sympathetic trunk or removal of terminal ganglia leads to decentralization, not denervation of the blood vessels. True denervation follows division or crush of the sciatic and femoral nerves. Following recovery from sciatic or femoral crush the pattern of peripheral innervation appears histochemically normal. However, there is no return of the normal vasodilator response to oxytocin. It is concluded that a normal response to oxytocin does not return even after long-term recovery from sympathetic injury, nor does its effect depend on a normal pattern of peripheral adrenergic innervation, but on an unknown more central activity of the sympathetic nervous system.
D000818:Animals; D001158:Arteries / Q000378:metabolism; D001808:Blood Vessels / Q000187:drug effects* / Q000294:innervation; D003094:Collagen / Q000378:metabolism; D004285:Dogs; D004549:Elastin / Q000378:metabolism; D005267:Femoral Nerve / Q000502:physiology; D006614:Hindlimb; D009409:Nerve Crush; D009416:Nerve Regeneration; D010121:Oxytocin / Q000494:pharmacology*; D012039:Regional Blood Flow / Q000187:drug effects; D012584:Sciatic Nerve / Q000502:physiology; D013564:Sympathetic Nervous System / Q000502:physiology*; D013997:Time Factors; D014665:Vasodilator Agents
D014665:Vasodilator Agents; D010121:Oxytocin; D003094:Collagen; D004549:Elastin