Tumor-specific transplantation immunity to intracerebral challenge with cells from a methylnitrosourea- induced brain tumor.
Tumor-specific transplantation immunity was demonstrated in syngenic rats immunized and challenged with tumor cells (T9) from an N-methyl N-nitrosourea-induced brain tumor. All unimmunized rats and rats pretreated with normal glial cells in complete Freund's adjuvant or with adjuvant alone died of intracerebral (i.c.) neoplasia at approximately 3 weeks post-challenge. Rats which were immunized with T9 cells with or without adjuvant failed to develop i.c. tumors by 6 weeks even though the challenge dose was 2 logs greater than a dose which consistently resulted in neoplasia in unimmunized rats.
D000818:Animals; D000937:Antigen-Antibody Reactions; D000951:Antigens, Neoplasm; D001254:Astrocytoma / Q000139:chemically induced / Q000276:immunology*; D001932:Brain Neoplasms / Q000139:chemically induced / Q000276:immunology*; D004195:Disease Models, Animal; D005620:Freund's Adjuvant; D007167:Immunotherapy; D008770:Methylnitrosourea; D009368:Neoplasm Transplantation; D051381:Rats; D014181:Transplantation Immunology; D014184:Transplantation, Homologous
D000951:Antigens, Neoplasm; D008770:Methylnitrosourea; D005620:Freund's Adjuvant