title: [Nucleoprotein melting. I. Theory of helix-coil transition of DNA in the presence of proteins with cooperative character of interaction under conditions of reversible binding].
abstract: Helix-coil transition of DNA with attached extended ligands able to interact with one another during adsorption on DNA (cooperative or uncooperative binding) has been considered. The general formulae describing dependence of polymer melting curve on concentration of attached ligands have been obtained. It has been shown that cooperativity of interaction with DNA stipulates for two phase profile of the melting curve. The results obtained show that proteins which interact with DNA cooperatively may cause two phase helix-coil transition under conditions of reversible binding.
mesh_terms: D004247:DNA; D003852:Deoxyribonucleoproteins; D008024:Ligands; D008433:Mathematics; D009690:Nucleic Acid Conformation; D009691:Nucleic Acid Denaturation; D009698:Nucleoproteins; D011485:Protein Binding; D011487:Protein Conformation
chemical_list: D003852:Deoxyribonucleoproteins; D008024:Ligands; D009698:Nucleoproteins; D004247:DNA
vernacular_title: Issledovanie plavleniia nukleoproteidov. I. teoriia perekhoda spiral'-klubok DNK v prisutstvii belkov pri obratinom sviazyvanii.