The haemodynamic response to salt and water loading in patients with end-stage renal disease and anephric man.
1. Patients with end-stage renal disease and anephric patients underwent expansion and depletion of body fluids with salt and water. This resulted in four different sequential haemodynamic patterns: (i) no significant increase in blood pressure; (ii) increase in blood pressure associated with a rise in cardiac output and no effect on total peripheral resistance; (iii) increase in cardiac output followed by a rise in blood pressure and total peripheral resistance; (iv) increase in total peripheral resistance and blood pressure without significant changes in cardiac output. 2. It is concluded that an initial rise in cardiac output is not necessary to increase-blood pressure in either anephric man or patients with end-stage renaldisease.
D001794:Blood Pressure; D001826:Body Fluids; D002302:Cardiac Output; D006801:Humans; D007676:Kidney Failure, Chronic / Q000503:physiopathology*; D008297:Male; D008875:Middle Aged; D009392:Nephrectomy; D012964:Sodium / Q000378:metabolism; D013997:Time Factors; D014655:Vascular Resistance; D014867:Water / Q000378:metabolism
D014867:Water; D012964:Sodium