title: [Local-regional dental anesthesia without vasoconstrictors].
abstract: Since Braun in 1905 first associated adrenalin with Einhorn's novocaine (procaine) to augment anaesthetic action, many attempts have been made to replace this vasoconstrictor because of the often severe inconveniences it can cause (cardiovasculopathic, arteriosclerotic, etc.). Reduction in dosimetry is recalled in brief: 1-corbasil; vasopressin; nor-adrenalin. It is personally considered that none of these measures ever successfully replaced adrenalin, nor did they prove to be so harmless as was originally believed. Finally, the refinement of biochemical research enabled more powerful and less toxic locoregional anaesthetics to be marketed and these provided ideal anaesthesia without vasoconstrictors. Pure carbocaine has been personally used exclusively for more than four years, with the two-fold advantage of practically completely avoiding any general inconvenience, particularly in cardionephrotics, diabetics, etc. and, in plexic (or terminal) injections, avoiding the threat of ischaemia which is the most frequent cause of alveolitis and of secondary haemorrhage. This locoregional anaesthetic without vasoconstrictor is therefore recommended, while the vast majority of clinics continue to use anaesthetics associated wtih non-indispensable and dangerous vasoconstrictors.
mesh_terms: D000328:Adult; D000766:Anesthesia, Dental / Q000379:methods*; D006801:Humans; D006980:Hyperthyroidism; D008012:Lidocaine / Q000494:pharmacology; D008297:Male; D008619:Mepivacaine / Q000494:pharmacology; D009407:Nerve Block; D012907:Smoking; D014081:Tooth Extraction; D014662:Vasoconstrictor Agents / Q000009:adverse effects
chemical_list: D014662:Vasoconstrictor Agents; D008012:Lidocaine; D008619:Mepivacaine
vernacular_title: Anestesia loco-regionale in odontostomatologia senza vasocostrittore