Influence of food on the absorption from different types of iron tablets.
The influence of a standardized breakfast meal on the absorption of iron from two types of iron tablets - rapidly-disintegrating and slow-release tablets - was studied in 24 healthy subjects, using a serum iron technique and whole-body counter measurements. The meal markedly reduced the absorption of iron from both types of tablets. An 8-fold reduction was found with the rapidly-disintegrating tablets and a 3-fold reduction with the slow-release tablets. Under fasting conditions the rapidly-disintegrating tablets were significantly better absorbed than the slow-release tablets, whereas the reverse was found when the tablets were given with the meal.
D000328:Adult; D003692:Delayed-Action Preparations; D005502:Food; D006801:Humans; D007408:Intestinal Absorption; D007501:Iron / Q000008:administration & dosage / Q000097:blood / Q000378:metabolism*; D008297:Male; D013607:Tablets
D003692:Delayed-Action Preparations; D013607:Tablets; D007501:Iron