Vitamin A acid and wound healing.
After preparatory treatment with 1% vitamin A acid for 3 days, healing of standardized wounds was accelerated by 18%, compared with a control group. The histological findings revealed as causes a general activation of epidermis, resp. signs of proliferation with inhibition of normal differentiation and hornification. These well known alterations due to vitamin A acid treatment are clearly visible in all epidermal layers. Obviously the activation of epidermis occurs when a remainder of the wound normally is healing by epithelization, that is at an area of 50 mm2. The profit of time in this sense can be defined unequivocally from the performed animal experiments.
D000818:Animals; D002455:Cell Division / Q000187:drug effects; D005260:Female; D051381:Rats; D013997:Time Factors; D014212:Tretinoin / Q000008:administration & dosage / Q000494:pharmacology*; D014801:Vitamin A / Q000031:analogs & derivatives*; D014945:Wound Healing / Q000187:drug effects*
D014801:Vitamin A; D014212:Tretinoin