Acute cardiovascular responses to radioprotective mixture of cystamine and 5-methoxytryptamine in rats.
I.p. administration of radioprotective mixture of cystamine (18 mg base/kg) and 5-methoxytryptamine (3 mg base/kg) to anesthetized rats induced the depression of hemodynamics. Decrease of cardiac output, hypotension, bradycardia, increase in peripheral vascular resistance, the escape of plasma from the vascular stream, pronounced diminution of blood flow in the spleen and other tissues were determined. Pharmacological properties of the protective can contribute to its radioprotective efficiency in the whole mammalian organism.
D008735:5-Methoxytryptamine / Q000008:administration & dosage / Q000494:pharmacology*; D000818:Animals; D003538:Cystamine / Q000008:administration & dosage / Q000494:pharmacology*; D004338:Drug Combinations; D005260:Female; D006439:Hemodynamics / Q000187:drug effects*; D051381:Rats; D014363:Tryptamines / Q000494:pharmacology*
D004338:Drug Combinations; D014363:Tryptamines; D008735:5-Methoxytryptamine; D003538:Cystamine