Observation on the familial appearance of diseases associated with metabolic disorders of the mother.
The familial appearnace of diseases in which a metabolic disorder of the mother causes foetal damage is examined and illustrated with typical pedigrees. The expected frequencies with which relatives of the probands are at risk are tabulated, and the effect of reduced maternal fertility is discussed. The familial appearance of disease is compared with that produced by maternal--foetal antigenic imcompatibility.
D005260:Female; D005808:Genes, Recessive; D006801:Humans; D008431:Maternal-Fetal Exchange; D008661:Metabolism, Inborn Errors / Q000235:genetics*; D010375:Pedigree; D010661:Phenylketonurias / Q000235:genetics; D011247:Pregnancy; D012306:Risk