DMBA and immunosuppression in the Syrian golden hamster.
The immunosuppressive effects of topically applied 9, 10 dimethyl 1, 2 benzanthracene (DMBA) were investigated in the Syrian Golden hamster. Tri-weekly doses of DMBA were administered, with some hamsters receiving both DMBA and X-radiation. DMBA and DMBA-plus-radiation groups demonstrated decreased immune responsiveness relative to their control counterparts. Potential immunosuppressive effects of carcinogen and carcinoma are discussed.
D000818:Animals; D002277:Carcinoma / Q000139:chemically induced / Q000276:immunology; D006224:Cricetinae; D006386:Hemagglutination Tests; D007109:Immunity / Q000187:drug effects* / Q000528:radiation effects; D007165:Immunosuppression Therapy; D007166:Immunosuppressive Agents; D008297:Male; D009062:Mouth Neoplasms / Q000139:chemically induced / Q000276:immunology; D009374:Neoplasms, Experimental / Q000139:chemically induced / Q000276:immunology
D007166:Immunosuppressive Agents