title: Chronic toxicity and carcinogenicity studies with FWAs.
abstract: Compounds (1), (2), (3), and (4) caused no adverse toxic effects and yielded no evidence of carcinogenic activity in a 2-year feeding study in albino rats at dietary levels up to 1000 ppm. Compounds (2), (3) and (4) were without effect in a 2-year study in beagle dogs at levels up to 2000 ppm. Compound (1) at levels of 400 and 1000 ppm led to decreased weight gains in some dogs and caused doserelated pathology consisting of inflammatory changes on the serosal surfaces of abdominal viscera and increased hematopoietic acitivty of the spleen and liver cords. These effect could have been due to the feeding of material, without adjustment of pH, for the first 30 weeks of the study.
mesh_terms: D000375:Aging; D000818:Animals; D001713:Biphenyl Compounds / Q000494:pharmacology; D001835:Body Weight / Q000187:drug effects; D002273:Carcinogens / Q000494:pharmacology*; D004396:Coloring Agents / Q000494:pharmacology* / Q000633:toxicity; D004032:Diet; D004285:Dogs; D005260:Female; D008297:Male; D009929:Organ Size / Q000187:drug effects; D051381:Rats; D013045:Species Specificity; D013267:Stilbenes / Q000494:pharmacology; D014230:Triazoles / Q000494:pharmacology
chemical_list: D001713:Biphenyl Compounds; D002273:Carcinogens; D004396:Coloring Agents; D013267:Stilbenes; D014230:Triazoles