Candida arthritis treated with amphotericin B.
This report describes a patient with acute lymphoblastic leukemia who developed arthritis of the knee caused by Candida tropicalis. Systemic therapy with amphotericin B apparently suppressed but did not eliminate the infection. Resolution of the arthritis occurred only after three intra-articular injections of amphotericin B. Intra-articular administration of amphotericin B may be a useful adjunct to systemic antifungal therapy in the treatment of these infections.
D000666:Amphotericin B / Q000008:administration & dosage / Q000627:therapeutic use*; D001170:Arthritis, Infectious / Q000150:complications / Q000188:drug therapy*; D002177:Candidiasis / Q000150:complications / Q000188:drug therapy*; D002648:Child; D005260:Female; D006801:Humans; D007270:Injections, Intra-Articular; D007275:Injections, Intravenous; D007719:Knee Joint / Q000382:microbiology; D007945:Leukemia, Lymphoid / Q000150:complications*
D000666:Amphotericin B