T cell leukaemia in the rat: stable marker chromosome in leukaemic cells.
The karyotype of a transplantable T cell leukaemia which arose originally in a PVG strain rat undergoing chronic internal beta irradiation of the spleen was examined and a marker chromosome was found. Although the leukaemia progressively became more acute during 4 years of continuous passage the marker did not change. Cytogenetic analysis of normal rats given an acute exposure to external irradiation revealed, among other abnormalities, a marked of the same morphology indicating that the original marker was probably radiation induced. This is the first description of a stable marker chromosome in an experimental animal leukaemia.
D000818:Animals; D002869:Chromosome Aberrations; D002875:Chromosomes / Q000528:radiation effects; D005260:Female; D007621:Karyotyping; D007942:Leukemia, Experimental / Q000235:genetics; D007945:Leukemia, Lymphoid / Q000235:genetics*; D007953:Leukemia, Radiation-Induced / Q000235:genetics*; D009368:Neoplasm Transplantation; D051381:Rats; D011919:Rats, Inbred Strains; D014184:Transplantation, Homologous