Cardiac effects of insulin, glucose, and potassium.
Glucose-insulin-potassium (G.I.P.) infusions have been recommended as a useful adjunct to the management of severe congestive heart failure. Ten patients with cardiac disease underwent a diagnostic cardiac catheterization. Pressures and cardiac output were obtained prior to and immediately after the 10 minute infusion of a mixture containing 50 grams of glucose, 10 mEq of potassium and 20 units of insulin. (Table: see text). G.I.P. infusions can increase the cardiac index. This is due to a combined effect of volume expansion and catecholamine stimulation.
D000328:Adult; D004338:Drug Combinations; D005260:Female; D005947:Glucose / Q000494:pharmacology*; D006331:Heart Diseases / Q000503:physiopathology*; D006439:Hemodynamics / Q000187:drug effects*; D006801:Humans; D007328:Insulin / Q000494:pharmacology*; D008297:Male; D008875:Middle Aged; D011188:Potassium / Q000494:pharmacology*
D004338:Drug Combinations; D007328:Insulin; D005947:Glucose; D011188:Potassium