Rapid and selective induction of erythroleukemia in female Donryu rats by continuous oral administration of 1-ethyl-1-nitrosourea.
Three groups of female Donryu rats were given continuously 1-ethyl-1-nitrosourea, 400, 200, or 100 mg/liter, in their drinking water. Leukemias developed in 94 of 104 (92%) rats surviving more than 6 experimental weeks. Of the leukemias, the erythroleukemias were induced most frequently, rapidly, and selectively. Other types of leukemias were found in a few rats of the high-dose group and, in some cases, in rats of the low-dose group. Tumors were also induced in the digestive tract, mammary glands, ear duct, and other organs, but their incidences were lower than 24%.
D000284:Administration, Oral; D000818:Animals; D004305:Dose-Response Relationship, Drug; D004428:Ear Neoplasms / Q000139:chemically induced; D005038:Ethylnitrosourea / Q000008:administration & dosage / Q000633:toxicity*; D005260:Female; D005770:Gastrointestinal Neoplasms / Q000139:chemically induced; D004915:Leukemia, Erythroblastic, Acute / Q000139:chemically induced*; D007942:Leukemia, Experimental / Q000139:chemically induced; D007951:Leukemia, Myeloid / Q000139:chemically induced; D015470:Leukemia, Myeloid, Acute / Q000139:chemically induced; D008325:Mammary Neoplasms, Experimental / Q000139:chemically induced; D009607:Nitrosourea Compounds / Q000633:toxicity*; D051381:Rats
D009607:Nitrosourea Compounds; D005038:Ethylnitrosourea