Surface-chemical studies on chlorhexidine and related compounds: I. Effects at air-water, n-hexane-water, and hydroxyapatite-water interfaces.
The comparative ability of chlorhexidine diacetate and structurally related compounds to generate surface pressure at air-water and n-hexane-water interfaces, and to adsorb to hydroxyapatite, was determined. The order of effectiveness generally evident was 1-(p-chlorophenyl)-5-n-octylbiguanide acetate is greater than chlorhexidine diacetate 1-(p-chlorophenyl)-5-n-hexylbiguanide acetate is greater than 1-(p-chlorophenyl)-5-n-propylbiguanide acetate is greater than p-chlorophenylbiguanide acetate p-chlorophenylguanidine acetate.
D000327:Adsorption; D000388:Air; D001645:Biguanides / Q000378:metabolism; D006882:Hydroxyapatites / Q000378:metabolism; D008968:Molecular Conformation; D011312:Pressure; D013329:Structure-Activity Relationship; D013499:Surface Properties; D013500:Surface Tension; D014867:Water / Q000378:metabolism
D001645:Biguanides; D006882:Hydroxyapatites; D014867:Water