Effect of dimethyl sulfoxide and hydrogen peroxide on tissue gas tensions.
Tissue gas levels were measured in experimental skin flaps in rabbits, rats, and pigs. Devascularization of the flaps led to a fall in PO2 and a rise in PCO2 levels. Application of DMSO to ischemic rabbit flaps led to a fall in PCO2, DMSO and H2O2 led to a rise in PO2, an effect that lasted up to 90 min. Neither drug had an effect on the gas levels of flaps in either rats or pigs.
D000818:Animals; D002245:Carbon Dioxide / Q000032:analysis; D004058:Diffusion; D004121:Dimethyl Sulfoxide / Q000494:pharmacology*; D006861:Hydrogen Peroxide / Q000494:pharmacology*; D009584:Nitrogen / Q000032:analysis; D010100:Oxygen / Q000032:analysis; D011312:Pressure; D011817:Rabbits; D051381:Rats; D012039:Regional Blood Flow / Q000187:drug effects; D012867:Skin / Q000098:blood supply / Q000187:drug effects*; D013045:Species Specificity; D013552:Swine
D002245:Carbon Dioxide; D006861:Hydrogen Peroxide; D009584:Nitrogen; D010100:Oxygen; D004121:Dimethyl Sulfoxide