The role of myocardial membrane lipids in the development of cardiac necrosis.
1. The fatty acid composition of cardiac membrane lipids is influenced by age, sex, diet and other factors. 2. The relative amounts of various polyunsaturated fatty acids in cardiac lipids influence markedly the development of myocardial necrosis and mortality following overstimulation with isoproterenol. 3. The availability and metabolism of arachidonic acid may play an important role in regulation of cardiac metabolism.
D000255:Adenosine Triphosphate / Q000378:metabolism; D000367:Age Factors; D000818:Animals; D001095:Arachidonic Acids / Q000378:metabolism; D004041:Dietary Fats; D004734:Energy Metabolism; D005227:Fatty Acids / Q000032:analysis; D005260:Female; D006801:Humans; D007545:Isoproterenol / Q000494:pharmacology; D050356:Lipid Metabolism; D008055:Lipids / Q000032:analysis; D008297:Male; D008566:Membranes / Q000378:metabolism; D009203:Myocardial Infarction / Q000378:metabolism*; D009206:Myocardium / Q000378:metabolism* / Q000473:pathology; D009336:Necrosis; D010725:Phosphocreatine / Q000378:metabolism; D051381:Rats; D012737:Sex Factors
D001095:Arachidonic Acids; D004041:Dietary Fats; D005227:Fatty Acids; D008055:Lipids; D010725:Phosphocreatine; D000255:Adenosine Triphosphate; D007545:Isoproterenol