Human myelogenous (Ph+) leukemia cell line: transplantation into athymic mice.
Chronic myelogenous leukemia (CML) cells from line K-562, containing the Philadelphia (Ph1) chromosome, were transplanted into nude mice and grew as solid vascularized tumors containing cells like those seen in the patient and in the cultures. Cells taken from the tumors were near triphoid and retained all human chromosome markers in culture.
D000818:Animals; D002460:Cell Line; D002869:Chromosome Aberrations; D002904:Chromosomes, Human, 21-22 and Y; D006801:Humans; D007942:Leukemia, Experimental / Q000209:etiology / Q000235:genetics / Q000473:pathology; D007951:Leukemia, Myeloid / Q000098:blood supply / Q000235:genetics / Q000473:pathology; D051379:Mice; D008819:Mice, Nude; D009368:Neoplasm Transplantation; D009374:Neoplasms, Experimental / Q000098:blood supply; D014178:Translocation, Genetic; D014183:Transplantation, Heterologous