Antimalarial drugs and reduced incidence of dental plaque.
Known antimalarial compunds from several chemical classes were tested for their ability to inhibit in vitro growth of microorganisms causing dental plaque and to prevent the development of plaque in a hamster model. Approximately a third of the compounds tested inhibited in vitro growth; however, none prevented development of plaque.
D000190:Actinomyces / Q000187:drug effects / Q000254:growth & development; D000655:Amodiaquine / Q000494:pharmacology; D000818:Animals; D000962:Antimalarials / Q000494:pharmacology*; D002478:Cells, Cultured; D002738:Chloroquine / Q000494:pharmacology; D006224:Cricetinae; D003622:Dapsone / Q000494:pharmacology; D003773:Dental Plaque / Q000378:metabolism / Q000382:microbiology / Q000517:prevention & control*; D008297:Male; D011319:Primaquine / Q000494:pharmacology; D011739:Pyrimethamine / Q000494:pharmacology; D011803:Quinine / Q000494:pharmacology; D013291:Streptococcus / Q000187:drug effects / Q000254:growth & development; D013415:Sulfalene / Q000494:pharmacology; D013752:Tetracycline / Q000494:pharmacology; D014295:Trimethoprim / Q000494:pharmacology
D000962:Antimalarials; D000655:Amodiaquine; D002738:Chloroquine; D003622:Dapsone; D011803:Quinine; D014295:Trimethoprim; D013752:Tetracycline; D011319:Primaquine; D013415:Sulfalene; D011739:Pyrimethamine