Correlation of degradative rates of proteins with a parameter calculated from amino acid composition and subunit size.
A parameter is developed which relates the amino acid composition and subunit size of a protein to the degradative rate in vivo. This parameter was calculated for 11 rat liver proteins and a plot versus the half-lives of these proteins is linear and has a coefficient of correlation of -0.96. Evidence is presented which suggests that the density of excess acidic amino acids on the surface of the protein is the most important factor in determining differential turnover.
D000596:Amino Acids / Q000032:analysis; D000818:Animals; D002417:Cattle; D004798:Enzymes / Q000378:metabolism; D006207:Half-Life; D008099:Liver / Q000378:metabolism; D051379:Mice; D008954:Models, Biological; D008970:Molecular Weight; D009132:Muscles / Q000378:metabolism; D011487:Protein Conformation; D011506:Proteins / Q000378:metabolism*; D011817:Rabbits; D051381:Rats; D013329:Structure-Activity Relationship; D013499:Surface Properties; D013552:Swine
D000596:Amino Acids; D004798:Enzymes; D011506:Proteins