Determination of renin-dependency and sodium-dependency in the three renin sub-groups of essential hypertension.
1. In all three renin sub-groups of essential hypertension, the state of sodium balance determines the degree of participation of the renin-angiotensin system in sustaining high blood pressure. 2. Even the low-renin type can become renin-dependent when sufficient sodium depletion has bee achieved. 3. The main difference between patients of these sub-groups appears to be their variable capacity to become depleted of sodium under standard dietary regimens.
D000450:Aldosterone / Q000097:blood; D000804:Angiotensin II / Q000502:physiology; D001794:Blood Pressure / Q000187:drug effects; D006801:Humans; D006973:Hypertension / Q000378:metabolism*; D008297:Male; D012083:Renin / Q000097:blood*; D012504:Saralasin / Q000494:pharmacology; D012964:Sodium / Q000378:metabolism*
D000804:Angiotensin II; D000450:Aldosterone; D012964:Sodium; D012083:Renin; D012504:Saralasin