Serial hexachlorophene blood levels in the premature infant.
The concentration of hexachlorophene was determined in serial blood samples taken from seven premature infants washed with pHisoHex. Results indicated that after a single wash with 5ml of pHisoHex, blood concentrations reached a maximum of 0.75-1.20mug/ml two to four days after application. The results obtained in this study confirm that the dermal absorption of hexachlorophene is greater in premature than in full-term infants. Use of hexachlorophene for infants. Use of hexachlorophene for infants of birth weight less than 2kg has now been discontinued at Queen Mary Hospital and the amount of pHisoHex used in the initial toileting of infants with birth weight more than 2kg has been limited to a single application of 5ml.
D001724:Birth Weight; D002849:Chromatography, Gas; D005865:Gestational Age; D006582:Hexachlorophene / Q000097:blood* / Q000378:metabolism; D006801:Humans; D007224:Infant Care; D007231:Infant, Newborn; D007234:Infant, Premature; D012869:Skin Absorption; D013997:Time Factors
D006582:Hexachlorophene