title: [Comparison of altered states of consciousness induced by the hallucinogens (--)-delta9-trans-tetrahydrocannabinol (delta9-THC) and N,N-dimethyltryptamine (DMT) (author's transl)].
abstract: The study compares altered states of consciousness induced by the hallucinogens (--)delta9-trans-Tetrahydrocannabinol (delta9-THC) and N,N-Dimethyltryptamine (DMT) using two placebo control groups. A total of 24 subjects received 250 mug delta9-THC p.o./kg body weight and 26 subjects were treated with 250 mug DMT i.m./kg. Placebo was given to 24 subjects. The effects were assessed by a questionnaire administered following the experimental conditions. Questionnaire items were combined into the following eight scales according to their content and several cirteria of the theory of mental testing: visual hallucinations (illusions), auditory hallucinations (illusions), impairment of memory and attention, depersonalization syndrome, deprealization syndrome, changes of body image, euphoric state and anxious-depressive state. The two hallucinogen groups differed significantly from placebo on all eight scales. No difference, however, between delta9-THC and DMT was significant. On the scale "optical hallucinations (illusions)" a tendency that DMT might have stronger effects than delta9-THC was found. Methodological problems of comparing different hallucinogens are discussed.
mesh_terms: D003072:Cognition Disorders / Q000139:chemically induced*; D003243:Consciousness / Q000187:drug effects*; D013759:Dronabinol / Q000494:pharmacology*; D006801:Humans; D004130:N,N-Dimethyltryptamine / Q000494:pharmacology*; D011795:Surveys and Questionnaires; D014363:Tryptamines / Q000494:pharmacology*
chemical_list: D014363:Tryptamines; D013759:Dronabinol; D004130:N,N-Dimethyltryptamine
vernacular_title: Vergleich veränderter Bewusstseinszustände unter den Halluzinogenen (--)-delta9-trans-Tetrahydrocannabinol (delta9-THC) und N,N-Dimethyltryptamin (DMT)