Morphology and DNA content of endometrial cancer nuclei under progestogen treatment.
Twelve endometrial cancers have been observed before and during progestogen treatment. Eight were well-differentiated and displayed an objective response. It was essentially characterized by a volumetric reduction of the nucleus and the disappearance of tetraploid nuclei. The DNA content remained diploid or near-diploid. Reduction of nuclear non DNA proteins under hormonal treatment is suggested.
D002467:Cell Nucleus / Q000032:analysis / Q000648:ultrastructure; D004273:DNA, Neoplasm / Q000032:analysis*; D005260:Female; D006801:Humans; D008234:Lynestrenol / Q000627:therapeutic use*; D014594:Uterine Neoplasms / Q000032:analysis / Q000188:drug therapy* / Q000648:ultrastructure
D004273:DNA, Neoplasm; D008234:Lynestrenol