Simultaneous synthesis of types I and III collagen by fibroblasts in culture.
Specific antibodies against types I and III collagens and procollagens were used to localize these proteins in cultured human cells. These studies indicate that the same cell makes both proteins. No type III procollagen synthesis was observed in cells from two patients with two patients with the Ehlers-Danlos type IV syndrome.
D001205:Ascorbic Acid / Q000494:pharmacology; D002460:Cell Line; D003094:Collagen / Q000096:biosynthesis* / Q000276:immunology; D004535:Ehlers-Danlos Syndrome / Q000378:metabolism; D005347:Fibroblasts / Q000378:metabolism*; D006801:Humans; D011347:Procollagen / Q000096:biosynthesis* / Q000276:immunology; D012867:Skin
D011347:Procollagen; D003094:Collagen; D001205:Ascorbic Acid