[Encephalic pseudotumoral toxoplasmosis in the course of blood diseases].
The authors report two cases, the first pathological and the second clinical of pseudo-tumoural cerebral toxoplasmosis, occurring during the course of blood diseases. They refer to the conditions of appearance of this rare complication, with only twenty cases recorded in the literature, during malignant blood diseases. They stress the primordial role of immunological deficiency related either to the underlying disease (especially Hodgkin's disease) or to immuno-suppressive therapy. The clinical picture, with little in the way of typical features, is thus that of a diffuse méningo-encéphalitis. Pseudo-tumoural forms are rare. The authors also stress the minimum conditions required for the validity of the dye test and the value of the diagnosis of cerebral toxoplasmosis. An association of sulphadiazine-purimethamine, active and effective, cured the second patient.
D001921:Brain / Q000473:pathology; D001927:Brain Diseases / Q000209:etiology / Q000276:immunology / Q000469:parasitology*; D004359:Drug Therapy, Combination; D005260:Female; D006689:Hodgkin Disease / Q000150:complications*; D006801:Humans; D007165:Immunosuppression Therapy / Q000009:adverse effects; D007951:Leukemia, Myeloid / Q000150:complications*; D008875:Middle Aged; D011739:Pyrimethamine / Q000627:therapeutic use; D012640:Seizures / Q000209:etiology; D013411:Sulfadiazine / Q000627:therapeutic use; D014123:Toxoplasmosis / Q000150:complications* / Q000188:drug therapy / Q000276:immunology
D013411:Sulfadiazine; D011739:Pyrimethamine
Toxoplasmose encéphalique pseudo-tumorale au cours d'une hémopathie. Deux observations