[Beta-propiolactone for cold sterilization of heart valve transplants].
Biologic cardiac valve substitutes were sterilized at room temperature using beta-propiolactone with a 0.5 vol.% solution within 120 minutes, with a 1.0 vol.% solution within 90 minutes, and with a 1.5 resp. 2.0 vol.% solution within 60 minutes. The physico-chemic properties of the graft can be influenced by appropriately chosen concentration and sterilizing period. Enlarged procedures for decontamination are not necessary because of the rapid dissolution of aqueous beta-propiolactone solutions.
D000818:Animals; D001021:Aortic Valve / Q000637:transplantation; D001419:Bacteria / Q000187:drug effects; D001705:Bioprosthesis; D006350:Heart Valve Prosthesis; D007783:Lactones / Q000494:pharmacology*; D011420:Propiolactone / Q000494:pharmacology*; D013242:Sterilization / Q000379:methods*; D013696:Temperature; D013997:Time Factors
D007783:Lactones; D011420:Propiolactone
Betapropiolakton zur Kalsterilisation von Herzklappentransplantaten.