title: [Dosage and cariostatic effect of mutanase in a rat experiment].
abstract: In caries tests on rats, mutanase (mu-1,3-glucanglucano-hydrolase) was admixed in different quantities to a cariogenic diet. The animals were fed eight times a day with a feeding machine for 25 days. A highly significant inhibition of fissural caries was achieved by concentrations of over 50 MU per gram of diet. As a simultaneous plaque reduction was not observed, the effect of the enzyme appears to be due to reduced adhesion or colonization capacity of streptococcus mutans strains in the fissures.
mesh_terms: D000818:Animals; D002327:Cariostatic Agents; D002448:Cell Adhesion / Q000187:drug effects; D003731:Dental Caries / Q000517:prevention & control*; D003773:Dental Plaque / Q000175:diagnosis; D004037:Diet, Cariogenic; D006026:Glycoside Hydrolases / Q000494:pharmacology*; D051381:Rats; D013295:Streptococcus mutans / Q000187:drug effects
chemical_list: D002327:Cariostatic Agents; D006026:Glycoside Hydrolases; C021780:exo-1,3-alpha-glucanase
vernacular_title: Dosis und kariostatische Wirkung von Mutanase im Rattenversuch