Lowering of blood pressure, plasma renin substrate, cholesterol and triglyceride by portacaval anastomosis in rats fed on a 60% sucrose/5% lard diet.
1. Portacaval anastomosis was carried out in ten rats fed on a 60% sucrose/5% lard diet, which induced moderate hypertriglyceridaemia, mild hypercholesterolaemia and normotension. 2. Plasma triglyceride was decreased to 45% of concentrations observed in ten pair-weighed control rats. 3. Plasma cholesterol concentrations were reduced to 58%, renin substrate to 70% and aortic blood pressure to 80% of control values by portacaval shunt surgery. 4. Individual blood pressures were directly related to plasma renin substrate concentrations.
D000818:Animals; D001794:Blood Pressure; D002784:Cholesterol / Q000097:blood*; D004036:Diet, Atherogenic; D004041:Dietary Fats; D005260:Female; D006973:Hypertension / Q000378:metabolism; D008297:Male; D011167:Portacaval Shunt, Surgical; D051381:Rats; D012083:Renin / Q000097:blood; D013395:Sucrose; D014280:Triglycerides / Q000097:blood*
D004041:Dietary Fats; D014280:Triglycerides; D013395:Sucrose; D002784:Cholesterol; D012083:Renin