Variation of the relative biologic effectiveness with tumor size using accelerated helium ions.
The RBE of an accelerated helium ion beam was determined on murine osteosarcomas ranging in size from single cells to visibly detectable lung colonies of approximately 1 X 10(-2) mm3. That the RBE increased as tumor size increased provides some biologic basis for the selection of advanced cases of neoplasia for clinical trials using relatively high LET radiation sources.
D000818:Animals; D003037:Cobalt Radioisotopes; D006371:Helium; D007477:Ions; D008175:Lung Neoplasms / Q000532:radiotherapy*; D051379:Mice; D009362:Neoplasm Metastasis; D009374:Neoplasms, Experimental / Q000532:radiotherapy; D012516:Osteosarcoma / Q000532:radiotherapy*; D011867:Radioisotope Teletherapy; D011868:Radioisotopes; D013997:Time Factors
D003037:Cobalt Radioisotopes; D007477:Ions; D011868:Radioisotopes; D006371:Helium