Heritable cell cycle disturbances and late recovery in x-irradiated murine lymphoma L5178Y-S cell populations in vitro.
1. Ionizing radiation can induce in mammalian cells, besides the lethal effects, also heritable damages which retard cell cycle traverse for considerable humber of cell generationsl 2. Radiation-induced heritable lesions in murine leukaemic lymphoblasts L5178Y-S affect progesssion of the cells through the G2 phase of the cell cycle. 3. Late recovery of proliferative activity which must be connected with elimination of the G2 block is a common phenomenon in the heritably damaged L5178Y-S sublines derived from single cells. 4. A possibility should be taken into consideration of employing the cells heritably damaged by radiation as convenient models for studies on some disturbances which accompany ageing of the mammalian cells. 5. It seems that results of studies on both the cells heritably damaged by radiation and the ageing cells could be useful for evaluation of possibilities of prevention, control or elimination of the heritable cell cycle disturbances.
D000818:Animals; D001345:Autoradiography; D003585:Cell Biology; D002460:Cell Line; D002470:Cell Survival / Q000528:radiation effects; D066298:In Vitro Techniques; D007945:Leukemia, Lymphoid; D051379:Mice; D008938:Mitosis; D008954:Models, Biological; D011830:Radiation Effects; D013997:Time Factors