Investigation of carbohydrate metabolism and somatomedin in osteosarcoma patients.
Altered carbohydrate metabolism associated with fibrosarcomas and chondrosarcomas has been well-documented in past literature. This report describes abnormal carbohydrate metabolism in 2 osteosarcoma patients, and abnormalities in growth hormone and somatomedin serum levels. Experimental evidence is presented showing in vitro suppression of osteosarcoma tumor cell proliferation by 17 beta Estradiol. Estrogen inhibition of linear bone growth, cartilage proliferation, and somatomedin is discussed with reference to possible estrogen therapy in osteosarcoma.
D000293:Adolescent; D001846:Bone Development / Q000187:drug effects; D050260:Carbohydrate Metabolism; D002356:Cartilage / Q000254:growth & development; D002478:Cells, Cultured; D004958:Estradiol / Q000494:pharmacology; D005260:Female; D013006:Growth Hormone / Q000097:blood; D006801:Humans; D008297:Male; D008727:Methotrexate / Q000494:pharmacology; D012516:Osteosarcoma / Q000188:drug therapy / Q000378:metabolism*; D012737:Sex Factors; D013002:Somatomedins / Q000097:blood*
D013002:Somatomedins; D004958:Estradiol; D013006:Growth Hormone; D008727:Methotrexate