A physiochemical approach to the study of amines as antiplaque agents.
Alkyl and aromatic amines were evaluated for inhibitory activity against S mutans 6715. Only the alkylamines were active and this may be due to their greater basicity. The agents that showed good activity were decylamine, dodecylamine, tetradecylamine, and hexadecylamine. In addition to the free bases, the hydrochloride and hydrofluoride salts were also tested for inhibitory activity and the same four agents were shown to be most active. These agents appear to hold good promise as antiplaque agents against S mutans 6715, therefore, further in vitro studies against other plaque-forming bacteria and toxicological and clinical evaluation seems to be warranted to determine the best clinical agent.
D000588:Amines / Q000494:pharmacology*; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D003773:Dental Plaque / Q000378:metabolism / Q000517:prevention & control*; D006801:Humans; D006851:Hydrochloric Acid / Q000494:pharmacology; D006858:Hydrofluoric Acid / Q000494:pharmacology; D066298:In Vitro Techniques; D013295:Streptococcus mutans / Q000187:drug effects; D013329:Structure-Activity Relationship
D000588:Amines; D006851:Hydrochloric Acid; D006858:Hydrofluoric Acid