title: The treatment of meningitis in infants with co-trimoxazole administered parenterally.
abstract: We found that co-trimoxazole had a good clinical and antibacterial effect when given parenterally to infants with infections of the central nervous system. We showed good concentrations in the serum and satisfactory penetrations into the cerebrospinal fluid. In one case, there was a side effect which may have been due to the sulpha or to the solvent. We think that at present the preparation should not be given to very premature babies or to babies with icterus, for the same reasons that we avoid using sulpha preparations in these conditions, but otherwise it may be of great use in difficult cases of meningitis caused by Gram-negative bacteria in infancy.
mesh_terms: D001424:Bacterial Infections / Q000188:drug therapy*; D004338:Drug Combinations; D004341:Drug Evaluation; D005500:Follow-Up Studies; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007275:Injections, Intravenous; D008297:Male; D008581:Meningitis / Q000188:drug therapy*; D013420:Sulfamethoxazole / Q000008:administration & dosage / Q000627:therapeutic use*; D014295:Trimethoprim / Q000008:administration & dosage / Q000627:therapeutic use*
chemical_list: D004338:Drug Combinations; D014295:Trimethoprim; D013420:Sulfamethoxazole