Amantadine decreases d-amphetamine stimulation and increases d-amphetamine anorexia in mice.
Amantadine hydrochloride (Symmetrel), an antiviral, antiparkinson agent that is most frequently used clinically at oral doses of 2 to 3 mg/kg, significantly decreased d-amphetamine-induced CNS stimulation (motor activity) and simultaneously increased d-amphetamine-induced anorexia (milk intake) in mice. Amantadine did this at oral doses of 2.5 and 5 mg/kg, which alone had no effect on either motor activity or milk intake.
D000547:Amantadine / Q000494:pharmacology*; D000818:Animals; D000855:Anorexia / Q000139:chemically induced*; D003913:Dextroamphetamine / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D004347:Drug Interactions; D001068:Feeding and Eating Disorders / Q000139:chemically induced*; D005260:Female; D006801:Humans; D051379:Mice; D009043:Motor Activity / Q000187:drug effects*
D000547:Amantadine; D003913:Dextroamphetamine