title: Saliva stimulation in dogs with permanent duct fistulae.
abstract: Saliva fluids were collected from catheters inserted in the duct openings of permanent paratid and sublingual duct fistulae prepared in dogs. In anesthetized dogs stimulants applied to the tongue had no effect on saliva output. In awake dogs topically applied sucrose (1.25%-20%) had no significant stimulating effect on salivary secertion when compared to water control responses. Citric acid (1.25%-20%), applied topically, resulted in dose-related fluid increases, with parotid volumes consistently higher than sublingual volumes. Pilocarpine (0.125 mg/kg, IV), elicited similar saliva volumes in awake and anesthetized animals; sublingual secretions were higher than parotid volumes. For comparing drug secretion or saliva composition in awake and anesthetized animals, use of the same, preferable an IV, stimulant administered on a milligram perper-kilogram basis is suggested.
mesh_terms: D000287:Administration, Topical; D000818:Animals; D002404:Catheterization / Q000295:instrumentation; D002951:Citrates / Q000008:administration & dosage / Q000494:pharmacology*; D004285:Dogs; D005260:Female; D008297:Male; D010306:Parotid Gland; D010862:Pilocarpine / Q000494:pharmacology*; D011095:Polyethylenes; D012463:Saliva / Q000378:metabolism*; D012636:Secretory Rate / Q000187:drug effects; D013361:Sublingual Gland; D013395:Sucrose / Q000494:pharmacology*
chemical_list: D002951:Citrates; D011095:Polyethylenes; D010862:Pilocarpine; D013395:Sucrose