Lidocaine's influence on brain amines in mice.
This series of experiments suggests that a relationship exists between convulsive doses of lidocaine and central depletion of 5-HT and DA. Since DA and usually 5-HT are regarded as central inhibitory transmitters, this study further supports the postulate that lidocaine's convulsive activity is by inhibition of central inhibitory pathways-possibly a dopaminergic or tryptaminergic pathway or both.
D000818:Animals; D001921:Brain / Q000378:metabolism*; D004298:Dopamine / Q000378:metabolism*; D004305:Dose-Response Relationship, Drug; D008012:Lidocaine / Q000008:administration & dosage / Q000009:adverse effects / Q000494:pharmacology*; D008297:Male; D008781:Methyltyrosines / Q000008:administration & dosage / Q000494:pharmacology; D051379:Mice; D009638:Norepinephrine / Q000378:metabolism*; D012640:Seizures / Q000139:chemically induced; D012701:Serotonin / Q000378:metabolism*
D008781:Methyltyrosines; D012701:Serotonin; D008012:Lidocaine; D004298:Dopamine; D009638:Norepinephrine