title: Diuretics in malignant effusions and edemas of generalized cancer.
abstract: Forty patients with generalized cancer complicated by water and electrolyte retention were treated with "medium" and "large" doses of furosemide and bumetanide with 35% and 40% objective positive response, respectively. A smaller percentage of patients benefited from these diuretics, mainly in the quality of their lives. Peaks" of diuresis lasting a few days were observed in positive diuretic response. It is therefore concluded that diuretics may be more effective in malignant conditions if administered in a "high-dose pulse" therapeutic schedule.
mesh_terms: D001201:Ascites / Q000150:complications / Q000188:drug therapy*; D001835:Body Weight / Q000187:drug effects; D002034:Bumetanide / Q000009:adverse effects / Q000627:therapeutic use*; D004232:Diuretics / Q000627:therapeutic use*; D004326:Drinking / Q000187:drug effects; D004487:Edema / Q000150:complications / Q000188:drug therapy*; D005665:Furosemide / Q000009:adverse effects / Q000627:therapeutic use*; D006801:Humans; D009369:Neoplasms / Q000150:complications*; D010998:Pleurisy / Q000150:complications / Q000188:drug therapy*; D014508:Urea / Q000097:blood; D014527:Uric Acid / Q000097:blood; D014883:Water-Electrolyte Imbalance / Q000139:chemically induced
chemical_list: D004232:Diuretics; D002034:Bumetanide; D014527:Uric Acid; D005665:Furosemide; D014508:Urea