title: Cytoenzymochemical effects of some antiblastic drugs and prediction of response to chemotherapy in acute leukemias.
abstract: Over 20 cytoenzymochemical tests were carried out in 152 patients with different types of acute leukemia to estimate the effects of some antiblastic drugs such as L-asparaginase, Purinethol, Methotrexate, Endoxan, Vinchristine, Cytosine Arabinoside a.o. The patients selected for the study were carefully examined before treatment at different moments during and/or at the end of the treatment. The effects of these drugs on the blast cells were mild when the cellular populations had a low rate of nucleic acid synthesis, high glycogenic score and high amounts of lipids or an important oxidative enzymatic activity. The enzymatic prediction tests: the acid phosphate deviation test and the succinic dehydrogenase inhibition test including the variant suggested by some of the authors - the latic dehydrogenase inhibition test - gave satisfactory results only in certain cases of acute leukemia.
mesh_terms: D000135:Acid Phosphatase / Q000097:blood*; D000970:Antineoplastic Agents / Q000494:pharmacology* / Q000627:therapeutic use; D004247:DNA / Q000378:metabolism; D007770:L-Lactate Dehydrogenase / Q000097:blood*; D007945:Leukemia, Lymphoid / Q000188:drug therapy*; D007948:Leukemia, Monocytic, Acute / Q000188:drug therapy*; D015470:Leukemia, Myeloid, Acute / Q000188:drug therapy*; D007962:Leukocytes / Q000201:enzymology / Q000378:metabolism*; D011379:Prognosis; D012313:RNA / Q000378:metabolism; D013385:Succinate Dehydrogenase / Q000097:blood*
chemical_list: D000970:Antineoplastic Agents; D012313:RNA; D004247:DNA; D007770:L-Lactate Dehydrogenase; D013385:Succinate Dehydrogenase; D000135:Acid Phosphatase