Reimplantation of freeze-treated mandibular bone.
Mandibular bone devitalized by freezing after removal from the body and subsequent reimplantation was observed for its potential to act as a framework of new bone formation. Clinical union and bony replacement occurred when the reimplanted bone was covered by healthy, well-vascularized soft tissue. New bone initially formed subperiosteally along the devitalized bone. Later specimens showed increased production of endosteal bone. The results suggest that a resected mandible subjected to freezing might be immediately reimplanted as a graft when the mandible is involved as part of a radical operative procedure. Further studies are indicated to evaluate this potential when the periosteal covering is removed.
D000818:Animals; D001854:Bone Marrow Cells; D003239:Connective Tissue Cells; D004285:Dogs; D005615:Freezing; D006097:Granulation Tissue / Q000166:cytology; D008334:Mandible / Q000166:cytology / Q000601:surgery / Q000637:transplantation*; D010012:Osteogenesis; D010027:Osteotomy; D011183:Postoperative Complications; D013529:Surgical Wound Dehiscence / Q000209:etiology; D014182:Transplantation, Autologous