Enhancement of the antiplaque value of antibacterial agents by enamel conditioning methods: III. Animal results.
A 1:1 water-paste slurry of a placebo and several experimental dentifrices was swabbed daily for six weeks on the teeth of albino rats, and the plaque collected on the teeth was measured in vivo first before the treatments began and one, two, three, and six weeks after. The results indicate that adding a suitable antimicrobial agent to a placebo dentifrice markedly reduced plaque accumulations on the teeth brushed with that product. When an enamel-conditioning vehicle was used instead of the placebo, the antiplaque effectiveness increased severalfold. It was concluded from the two first articles of this series 1,2 that adding antibacterial agents to enamel-conditioning systems resulted in the incorporation of the antimicrobial compound into enamel treated with these systems, and that enamel treated in such a fashion acquired marked antibacterial properties of its own. The data reported in this article support a third conclusion, namely, that the enamel-conditioning-antibacterial systems have a considerable antiplaque effect in laboratory rats.
D000818:Animals; D000891:Anti-Infective Agents, Local / Q000627:therapeutic use*; D001419:Bacteria / Q000187:drug effects; D003743:Dental Enamel; D003773:Dental Plaque / Q000517:prevention & control*; D003802:Dentifrices / Q000627:therapeutic use; D005260:Female; D008297:Male; D010919:Placebos; D051381:Rats; D012457:Salicylamides / Q000627:therapeutic use*; D012458:Salicylanilides / Q000494:pharmacology / Q000627:therapeutic use*
D000891:Anti-Infective Agents, Local; D003802:Dentifrices; D010919:Placebos; D012457:Salicylamides; D012458:Salicylanilides