Non-familial vitamin D-resistant hypophosphataemic osteomalacia of adult onset: case report.
An unusual form of osteomalacic bone disease in a middle-aged woman with a three-year history of widespread bone pain, pathological fractures and loss of height is discribed. Investigations revealed a persistent hypophosphataemia and an increased phosphate excretion index. Urinary glycine excretion was increased. An oral phosphate supplement led to rapid improvement. The features support the diagnosis of non-familial adult onset vitamin D-resistant hypophosphataemic osteomalacia.
D000328:Adult; D004351:Drug Resistance; D005260:Female; D006801:Humans; D010018:Osteomalacia / Q000188:drug therapy*; D010710:Phosphates / Q000097:blood* / Q000627:therapeutic use; D014807:Vitamin D / Q000627:therapeutic use*
D010710:Phosphates; D014807:Vitamin D