title: Oestrus, ovulation and plasma hormones after prostaglandin F2alpha in mares.
abstract: The luteolytic effect of PGF2alpha, administered by intrauterine infusion or subcutaneous injection during early dioestrus, was observed in mares of mixed breeds. An infusion of 10 mg on Days 7 to 9 after ovulation caused a sharp fall in plasma progesterone levels and induced oestrus and ovulation. Oestrus was significantly longer than in the natural cycle but the time of ovulation in relation to the end of oestrus was normal. The time of return to oestrus following luteolysis was not dependent on the amount of PGF2alpha within the range of doses given. Luteolysis could be induced as early as Day 5 following natural ovulation.
mesh_terms: D000735:Androstenedione / Q000097:blood; D000818:Animals; D003338:Corpus Luteum / Q000187:drug effects; D004958:Estradiol / Q000097:blood; D004970:Estrone / Q000097:blood; D004971:Estrus / Q000187:drug effects*; D005260:Female; D006736:Horses / Q000502:physiology*; D007986:Luteinizing Hormone / Q000097:blood; D010060:Ovulation / Q000187:drug effects*; D011247:Pregnancy; D011374:Progesterone / Q000097:blood*; D011460:Prostaglandins F / Q000008:administration & dosage / Q000494:pharmacology*; D013997:Time Factors
chemical_list: D011460:Prostaglandins F; D004970:Estrone; D000735:Androstenedione; D011374:Progesterone; D004958:Estradiol; D007986:Luteinizing Hormone