title: Deposition of histone onto the replicating chromosome: newly synthesized histone is not found near the replication fork.
abstract: We have studied the site of deposition of newly synthesized histone. It appears to be randomly distributed over the chromosomal material and does not become associated specifically with immediately post-replicational DNA, nor is it deposited in discrete continuous regions distal to the sites of DNA synthesis. The newly synthesized DNA, however, rapidly acquires a complement of chromosomal proteins; presumably, preexisting histones must migrate to become associated with post-replicational DNA.
mesh_terms: D002478:Cells, Cultured; D002843:Chromatin / Q000378:metabolism*; D002875:Chromosomes / Q000378:metabolism*; D004261:DNA Replication; D006657:Histones / Q000378:metabolism*
chemical_list: D002843:Chromatin; D006657:Histones