title: In vitro attachment of human gingival fibroblasts to root surfaces.
abstract: Human gingival fibroblasts were used to study the in vitro attachment of cells to the root surface of periodontally-involved teeth. The portion of the root exposed to the disease process had little or no cell attachment; on the remainder of the root, the cells attached normally. Prior extraction of the roots with phenol-water or the mechanical removal of diseased cementum allowed the cells to attach normally. All things being equal, the extrapolation of these data to an in vivo situation dictates that a clinical success would depend upon complete removal of toxic materials from diseased cementum or the removal of the cementum itself.
mesh_terms: D000328:Adult; D002448:Cell Adhesion; D002469:Cell Separation; D002478:Cells, Cultured; D003475:Curettage; D005347:Fibroblasts / Q000502:physiology*; D005881:Gingiva / Q000166:cytology* / Q000502:physiology; D006801:Humans; D008297:Male; D010510:Periodontal Diseases / Q000473:pathology; D010636:Phenols / Q000494:pharmacology; D014092:Tooth Root / Q000033:anatomy & histology* / Q000473:pathology / Q000601:surgery
chemical_list: D010636:Phenols