Acute lymphoblastic leukemia terminating as histiocytic medullary reticulosis.
A young man with acute lymphoblastic leukemia was treated with vincristine sulfate, prednisone, and intrathecally injected methotrexate sodium for central nervous system involvement. A good remission was induced, but three months later he had hepatosplenomegaly, an enlarging mediastinal mass, and progressive anemia. Histiocytic medullary reticulosis was confirmed by a bone marrow biopsy specimen. The patient died of respiratory failure because of infiltration of the lungs by malignant histiocytes.
D000208:Acute Disease; D000328:Adult; D000740:Anemia / Q000175:diagnosis; D001344:Autopsy; D001853:Bone Marrow / Q000473:pathology; D004912:Erythrocytes; D006529:Hepatomegaly / Q000175:diagnosis; D006801:Humans; D007945:Leukemia, Lymphoid / Q000188:drug therapy / Q000473:pathology*; D008198:Lymph Nodes / Q000473:pathology; D008206:Lymphatic Diseases / Q000473:pathology*; D008297:Male; D008727:Methotrexate / Q000627:therapeutic use; D010587:Phagocytosis; D011241:Prednisone / Q000627:therapeutic use; D012075:Remission, Spontaneous; D012131:Respiratory Insufficiency / Q000473:pathology; D012964:Sodium / Q000627:therapeutic use; D013163:Splenomegaly / Q000175:diagnosis; D013431:Sulfates / Q000627:therapeutic use; D014750:Vincristine / Q000627:therapeutic use
D013431:Sulfates; D014750:Vincristine; D012964:Sodium; D011241:Prednisone; D008727:Methotrexate