Fibrosarcoma of bone. A demographic, clinical and histopathological study of all cases recorded in the Swedish cancer registry from 1958 to 1968.
The clinical records, radiographs and histopathological material of all forty-one patients recorded as suffering from fibrosarcoma of bone in the Swedish Cancer Registry for the years 1958 to 1968 have been analysed; in addition, four cases were found on histological review of a series of osteosarcomas. From this re-examination, twenty-four patients with genuine fibrosarcoma of bone were identified; twenty-two had primary neoplasms and two secondary. No sex or geographical differences were found. The tumours showed a prevalence for patients in the adult and older age groups. Half of the tumours arose from femoral or tibial metaphysial bone adjacent to a knee joint. All the tumours were of the medullary type. Almost one-third presented with a pathological fracture, and soft-tissue extension had occurred in all but three tumours. In contrast to previous reports, these tumours were more malignant than osteosarcomas and showed a five-year survival rate of only 4-2 per cent. In accessible sites, ablative surgery was used as the primary treatment, Fibrosarcoma of bone is a distinctive lesion and should be distinguished carefully from periosteal and soft-tissue fibrosarcomas because of differences in prognosis and treatment.
D001707:Biopsy, Needle; D001859:Bone Neoplasms / Q000175:diagnosis / Q000453:epidemiology / Q000473:pathology*; D003710:Demography; D005260:Female; D005354:Fibrosarcoma / Q000175:diagnosis / Q000453:epidemiology / Q000473:pathology*; D006801:Humans; D008297:Male; D012516:Osteosarcoma / Q000453:epidemiology / Q000473:pathology; D011379:Prognosis; D012042:Registries; D012737:Sex Factors; D013548:Sweden