Inhibition of Friend virus (FVP)-induced erythropoiesis by an erythropoiesis-inhibitory factor (EIF).
An erythropoietin-independent murine erythroleukemia (FVp) has been used to evaluate the effects of an erythropoiesis-inhibitory factor (EIF) isolated from human urine. The consequent inhibition of FVp-induced erythropoiesis suggests that EIF exerts its effect independently of ESF. The inhibitory effect of EIF on FVp-induced erythropoiesis may reveal a potential for the physiological control of some types of erythroleukemia.
D000818:Animals; D004912:Erythrocytes / Q000378:metabolism; D004920:Erythropoiesis; D004921:Erythropoietin / Q000037:antagonists & inhibitors*; D005622:Friend murine leukemia virus; D006400:Hematocrit; D006801:Humans; D007504:Iron Radioisotopes; D004915:Leukemia, Erythroblastic, Acute; D051379:Mice; D008806:Mice, Inbred AKR; D009929:Organ Size; D013154:Spleen / Q000378:metabolism; D013163:Splenomegaly; D013997:Time Factors; D014556:Urine
D007504:Iron Radioisotopes; D004921:Erythropoietin