Hemodynamic changes in rats after radioprotective combination of cystamine administered subcutaneously and 5-methoxytryptamine injected intramuscularly.
Administration of cystamine (20 mg base/kg s.c.) and 5-methoxytryptamine (10 mg base/kg i.m.) with 12 minutes delay to anesthetized rats induced the depression of whole cardiovascular system, hemoconcentration and great blood flow decrease in the radiosensitive tissues. Distributionof lowered cardiac output preferred the fractions to brain, heart, liver and lungs. Hemodynamic responses to protective combination may participate in its radioprotective action.
D008735:5-Methoxytryptamine / Q000494:pharmacology*; D000818:Animals; D001775:Blood Circulation / Q000187:drug effects; D001794:Blood Pressure / Q000187:drug effects; D002302:Cardiac Output / Q000187:drug effects; D003538:Cystamine / Q000494:pharmacology*; D005260:Female; D006339:Heart Rate / Q000187:drug effects; D006439:Hemodynamics / Q000187:drug effects*; D007273:Injections, Intramuscular; D007279:Injections, Subcutaneous; D051381:Rats; D013997:Time Factors; D014363:Tryptamines / Q000494:pharmacology*; D014655:Vascular Resistance / Q000187:drug effects
D014363:Tryptamines; D008735:5-Methoxytryptamine; D003538:Cystamine