Electron microscopic study of the cytotoxicity of cadmium and mercury in vitro.
The cells treated with cadmium chloride showed severe changes: ribosomes disappeared, mitochondria showed various degrees of destruction, and the endoplasmic reticulum had a swollen and beadlike appearance. In cells treated with mercuric chloride, ribosomes increased in their density and rosette-like polysomes were predominantly observed. The effects of these two metallic ions were discussed.
D000818:Animals; D002104:Cadmium / Q000633:toxicity*; D002467:Cell Nucleus / Q000187:drug effects; D002478:Cells, Cultured; D004721:Endoplasmic Reticulum / Q000187:drug effects; D005347:Fibroblasts / Q000187:drug effects* / Q000648:ultrastructure; D008628:Mercury / Q000633:toxicity*; D051379:Mice; D008809:Mice, Inbred C3H; D008928:Mitochondria / Q000187:drug effects; D012270:Ribosomes / Q000187:drug effects
D002104:Cadmium; D008628:Mercury