Activity of catecholamines inactivating enzymes in heart muscle during anoxic cardioplegia in cardiosurgical patients.
On the model of anoxic cardioplegia in cardiosurgical patients the influence of anoxia on the activity of monoamine oxidase (MAO) and catechol-O-methyltransferase (COMPT) in right auricular tissue was studied. It was found out that the activity of COMT does not change during anoxia, the activity of MAO considerably increases. With regard to catecholamines stimulating effect upon cardiac metabolism as well as to their calorigenic and oxygen wasting effect the raise of MAO activity may be regarded as favourable phenomenon, because the hastened degradation of released catecholamines at least to a certain degree diminishes the disproportion between oxygen supply and actual oxygen need of the heart and by means of that mitigates the anoxic damage of myocardium.
D002303:Cardiac Output, Low / Q000209:etiology; D002394:Catechol O-Methyltransferase / Q000378:metabolism*; D006324:Heart Arrest, Induced; D006801:Humans; D000860:Hypoxia / Q000378:metabolism*; D008995:Monoamine Oxidase / Q000378:metabolism*; D009206:Myocardium / Q000201:enzymology / Q000378:metabolism*; D009638:Norepinephrine / Q000378:metabolism; D010101:Oxygen Consumption; D013997:Time Factors
D008995:Monoamine Oxidase; D002394:Catechol O-Methyltransferase; D009638:Norepinephrine