Reduction of the hypotensive effect of clonidine and alpha-methyldopa by various psychotropic drugs.
1. In chloralose-anaesthetized cats the centrally induced hypotensive effect of clonidine, and in some cases alpha-methyldopa, was diminished by pretreatment with a variety of tricyclic antidepressants and neuroleptic agents. 2. The interaction is assumed to occur at the central alpha-adrenoreceptors. Clonidine or alpha-methyl-noradrenaline (from alpha-methyldopa) are the agonists, and the aforementioned psychotropic drugs are the antagonists. 3. Psychotropic drugs which are not alpha-receptor blockers, like butyrophenone neuroleptics (pimozide and haloperidol) or benzodiazepine tranquillizers, do not significantly diminsh the centrally induced hypotensive effect of clonidine.
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects*; D002415:Cats; D003000:Clonidine / Q000037:antagonists & inhibitors*; D003864:Depression, Chemical; D007488:Iprindole / Q000494:pharmacology; D008750:Methyldopa / Q000037:antagonists & inhibitors*; D011619:Psychotropic Drugs / Q000494:pharmacology*
D011619:Psychotropic Drugs; D008750:Methyldopa; D007488:Iprindole; D003000:Clonidine