title: Pharmacological studies on retinoic acid in Wistar and in atrichos rats.
abstract: Retinoic acid produces some changes in the skin which could be interpreted as a mechanism of action: release of acid hydrolases and phosphatases, inflammatory reactions, increase in lipid synthesis and transport as an energy dependent phenomenon, increase in the lipid flux perhaps as a lipoprotein complex, since there is a rise in nucleic acid synthesis. Stimulation of bone remodeling is observed only when high dosage of retinoic acid is given orally.
mesh_terms: D000469:Alkaline Phosphatase / Q000097:blood; D000818:Animals; D001862:Bone Resorption; D001842:Bone and Bones / Q000187:drug effects*; D012867:Skin / Q000187:drug effects* / Q000378:metabolism; D014212:Tretinoin / Q000378:metabolism / Q000494:pharmacology*; D014801:Vitamin A / Q000031:analogs & derivatives*
chemical_list: D014801:Vitamin A; D014212:Tretinoin; D000469:Alkaline Phosphatase