Antistaphylococcal activity of sisomicin and four other aminoglycosides against strains sensitive and resistant to methicillin.
Five aminoglycosides were tested for inhibitory activity on 91 strains of Staphylococcus aureus, 39 of which were methicillin-resistant. The antistaphylococcal activity of these antibiotics was independent of the methicillin-resistance. Their order of decreasing effectiveness was: gentamicin greater than tobramycin = sisomicin greater than amikacin greater than kanamycin. Resistant strains were only found for the latter.
D000617:Aminoglycosides / Q000494:pharmacology; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D008712:Methicillin / Q000494:pharmacology; D008826:Microbial Sensitivity Tests; D010403:Penicillin Resistance; D012853:Sisomicin / Q000494:pharmacology*; D013210:Staphylococcus / Q000187:drug effects*
D000617:Aminoglycosides; D000900:Anti-Bacterial Agents; D008712:Methicillin; D012853:Sisomicin