Long-term effect of benzene in C57BL/6N mice.
Weaning male C57BL/6N mice received repeated subcutaneous injections of benzene in corn oil for 54 weeks. These mice and surviving controls were killed 104 weeks after the first injection. There was no evidence of carcinogenic activity in benzene-injected mice. A high incidence of amyloidosis developed in  mice of all treated and untreated groups. Butyinitrosourea, used as a positive control, induced lymphomas or leukemias (in most exposed mice) and intestinal tumors in a few.
D000686:Amyloidosis / Q000139:chemically induced; D000818:Animals; D001554:Benzene / Q000008:administration & dosage; D001835:Body Weight / Q000187:drug effects; D002273:Carcinogens; D004195:Disease Models, Animal; D007279:Injections, Subcutaneous; D007414:Intestinal Neoplasms / Q000139:chemically induced; D007951:Leukemia, Myeloid / Q000139:chemically induced; D008113:Liver Neoplasms / Q000139:chemically induced; D008175:Lung Neoplasms / Q000139:chemically induced; D008223:Lymphoma / Q000139:chemically induced; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D009369:Neoplasms / Q000139:chemically induced*; D009607:Nitrosourea Compounds; D010911:Pituitary Neoplasms / Q000139:chemically induced; D013274:Stomach Neoplasms / Q000139:chemically induced
D002273:Carcinogens; D009607:Nitrosourea Compounds; D001554:Benzene