Effect of sugar analogues on growth, sugar utilization, and acid production by Streptococcus mutans.
Studies on the effect of various structural analogues of glucose of phosphoenolpyruvate (PEP)-dependent sugar transport in Streptococcus mutans showed that sugars with alterations at carbon 2 were markedly inhibitory. Low concentrations of the nonfermentable analogue D-2-deoxyglucose (2-deoxyg) blocked the growth of S mutans in broth media containing various fermentable sugars. Acid production by S mutans from both exogenous glucose and intracellular storage polysaccharide was inhibited by 2-deoxyG. The analogue is bacteriostatic, and large quantities of intracellular 2-deoxyG-6-PO4 accumulate during exposure of S mutans to the sugar.
D000818:Animals; D001089:Arabinose / Q000494:pharmacology; D002642:Chick Embryo; D002854:Chromatography, Paper; D003837:Deoxy Sugars / Q000378:metabolism / Q000494:pharmacology*; D005632:Fructose / Q000494:pharmacology; D005643:Fucose / Q000494:pharmacology; D005690:Galactose / Q000494:pharmacology; D005947:Glucose / Q000031:analogs & derivatives* / Q000378:metabolism / Q000494:pharmacology; D005960:Glucosides / Q000494:pharmacology; D007700:Kinetics; D008358:Mannose / Q000494:pharmacology; D010085:Oxidative Phosphorylation / Q000187:drug effects; D010770:Phosphotransferases / Q000378:metabolism; D012210:Rhamnose / Q000494:pharmacology; D013291:Streptococcus / Q000187:drug effects* / Q000201:enzymology / Q000254:growth & development / Q000378:metabolism; D013400:Sugar Acids / Q000378:metabolism; D014994:Xylose / Q000494:pharmacology
D003837:Deoxy Sugars; D005960:Glucosides; D013400:Sugar Acids; D005643:Fucose; D005632:Fructose; D014994:Xylose; D001089:Arabinose; D010770:Phosphotransferases; D005947:Glucose; D008358:Mannose; D012210:Rhamnose; D005690:Galactose