The penetration of trimethoprim into seminal fluid and serum.
A series of determinations of the concentrations of trimethoprim in seminal fluid and serum was made during the treatment of 18 men. Trimethoprim could be demonstrated in an average concentration in serum of 1.8-2.0 mug per millilitre and in seminal fluid of between 1.0 and 1.5 mug per millilitre. At the same time it was demonstrated that the combination of trimethoprim and sulphamethoxazole (co-trimoxazole) has no effect on genital mycoplasma species.
D000328:Adult; D004338:Drug Combinations; D005832:Genital Diseases, Male / Q000188:drug therapy*; D006801:Humans; D008297:Male; D009175:Mycoplasma Infections / Q000188:drug therapy; D012661:Semen / Q000378:metabolism*; D013420:Sulfamethoxazole / Q000378:metabolism / Q000627:therapeutic use; D014295:Trimethoprim / Q000097:blood / Q000378:metabolism* / Q000627:therapeutic use
D004338:Drug Combinations; D014295:Trimethoprim; D013420:Sulfamethoxazole