The role of 11-deoxycorticosterone in human hypertension.
1. Using a newly developed and validated radioassay method, we have measured plasma 11-deoxycorticosterone concentrations in a wide spectrum of human hypertensive states. 2. Patients with essential and renovascular hypertension have normal plasma concentrations of 11-deoxycorticosterone. 3. Elevated concentrations are seen in some patients with primary aldosteronism, Cushing's syndrome, low-renin hypertension, and in adult hypertensive subjects with elevated urinary 17-ketosteroid excretion. 4. An aetiological role for deoxycorticosterone in certain forms of human hypertension appears likely.
D015068:17-Ketosteroids / Q000097:blood; D003480:Cushing Syndrome / Q000097:blood; D003900:Desoxycorticosterone / Q000097:blood*; D006801:Humans; D006929:Hyperaldosteronism / Q000097:blood; D006973:Hypertension / Q000097:blood* / Q000209:etiology
D015068:17-Ketosteroids; D003900:Desoxycorticosterone