Loss of resistance to methicillin and other antibiotics in Staphylococcus aureus associated with a chronic empyema.
A chronic empyema was investigated in a patient during a period of seven years. A strain of Staphylococcus aureus resistant to methicillin and four other antibiotics was isolated and the loss of all these determinants was shown to occur in vitro. A similarly sensitive organism was obtained directly from the patient during the later stages of his illness and the homogeneity of the phage patterns indicate that the organism was a true variant which evolved from the highly resistant one.
D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D002908:Chronic Disease; D004653:Empyema / Q000382:microbiology*; D006801:Humans; D008297:Male; D008712:Methicillin / Q000494:pharmacology*; D008875:Middle Aged; D010403:Penicillin Resistance; D013211:Staphylococcus aureus / Q000187:drug effects* / Q000302:isolation & purification
D000900:Anti-Bacterial Agents; D008712:Methicillin