title: Sarcoidosis of the upper respiratory tract and its relation to lupus pernio.
abstract: The authors present a personally studied series of 32 patients with sarcoidosis affecting the upper respiratory tract and nose. Twenty-five of these patients had lupus pernio (LP), which in 8 instances was accompanied by sarcoidosis of the upper respiratory tract (SURT). The 7 other patients had SURT (mucosal disease) without LP. There was a female to male ratio of 7:1. SURT presented mainly in the third decade, whereas LP presented mainly in the fourth and fifth. Despite this, SURT was as much a chronic manifestation of sarcoidosis as LP. Five of 11 patients (45%) presenting with SURT progressed to LP within 2 yr. Overall 26 patients (81%) had intrathoracic sarcoidosis, 19 patients (59%) had skin lesions other than LP, 10 patients (31%) had bone sarcoidosis, 7 patients (22%) had ocular lesions, and 6 patients (19%) had peripheral lymphadenopathy. The Kveim-Siltzbach skin-test was positive in 12 of 12 patients with SURT, making it a useful aid in the differential diagnosis of sarcoid granulomas in the nose. Two patients had nasal perforations, both of which followed a submucous resection.
mesh_terms: D000293:Adolescent; D000328:Adult; D002648:Child; D005260:Female; D006801:Humans; D007830:Larynx; D008297:Male; D008875:Middle Aged; D009092:Mucous Membrane; D009297:Nasal Mucosa; D009668:Nose Diseases / Q000150:complications / Q000601:surgery; D010614:Pharynx; D012140:Respiratory Tract Diseases / Q000150:complications*; D012507:Sarcoidosis / Q000150:complications*; D012871:Skin Diseases / Q000150:complications*; D012882:Skin Tests; D013896:Thoracic Diseases / Q000150:complications