A case of acute promyelocytic leukaemia with bullous, haemorrhagic and necrotic skin lesions.
Erythematous-oedematous-bullous skin lesions with necrotic vegetating and haemorrhagic evolution evocating atypical pemphigur or bullous reticulosis, revealed acute promyelocytic leukaemia. Histologically, vesicles and bullae were observed in the Malpighian layer and a dense infiltrate with atypical blasts in the dermis. Atypical promyelocytes (22%) were found in the bone marrow. The cytochemical features of promyelocytes, haemorrhage due to disseminated intravascular coagulation supported the diagnosis.
D000368:Aged; D001854:Bone Marrow Cells; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000097:blood / Q000150:complications* / Q000473:pathology; D008297:Male; D012867:Skin / Q000473:pathology; D012871:Skin Diseases / Q000097:blood / Q000209:etiology* / Q000473:pathology