Deposition of histone onto the replicating chromosome: newly synthesized histone is not found near the replication fork.
We have studied the site of deposition of newly synthesized histone. It appears to be randomly distributed over the chromosomal material and does not become associated specifically with immediately post-replicational DNA, nor is it deposited in discrete continuous regions distal to the sites of DNA synthesis. The newly synthesized DNA, however, rapidly acquires a complement of chromosomal proteins; presumably, preexisting histones must migrate to become associated with post-replicational DNA.
D002478:Cells, Cultured; D002843:Chromatin / Q000378:metabolism*; D002875:Chromosomes / Q000378:metabolism*; D004261:DNA Replication; D006657:Histones / Q000378:metabolism*
D002843:Chromatin; D006657:Histones