Amino acid metabolism of platelets in leukemia.
Platelets from patients with acute myelogenous leukemia, both before and after remission induction, were evaluated for their ability to incorporate D-[U-14C]glucose into the four amino acids, glutamine, asparagine, glutamic acid, and aspartic acid. Normal platelets incorporated about 80% of the activity into the amides, glutamine and asparagine, and only 20% into their respective amino acids, glutamic acid and aspartic acid. Platelets from patients with acute myelogenous leukemia in the acute stage showed a reversal of this pattern, which then returned to normal during remission. However, the concentration of amino acids was higher than normal, suggesting that remission platelets behaved like a young cell population. The abnormal pattern of labeling could be interpreted as a defect in the platelet citric acid cycle thereby compromising its energy source.
D000596:Amino Acids / Q000096:biosynthesis*; D001216:Asparagine / Q000096:biosynthesis; D001224:Aspartic Acid / Q000096:biosynthesis; D001792:Blood Platelets / Q000378:metabolism*; D005947:Glucose / Q000378:metabolism*; D005971:Glutamates / Q000096:biosynthesis; D005973:Glutamine / Q000096:biosynthesis; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000378:metabolism*; D012075:Remission, Spontaneous
D000596:Amino Acids; D005971:Glutamates; D005973:Glutamine; D001224:Aspartic Acid; D001216:Asparagine; D005947:Glucose