Missing Y chromosome in juvenile chronic myelogenous leukemia.
A child with Ph1-negative juvenile chronic myelogenous leukemia (CML) is presented. The only chromosomal abnormality in hematopoietic tissues consisted of an absent Y chromosome. While a missing Y chromosome in adult patients with CML may be associated with a better prognosis, the clinical course in our patient was as malignant as that usually observed in other children with Ph1-negative juvenile CML.
D000782:Aneuploidy; D001792:Blood Platelets; D002675:Child, Preschool; D006801:Humans; D007951:Leukemia, Myeloid / Q000097:blood / Q000235:genetics*; D008297:Male; D012730:Sex Chromosomes