title: Heat mutagenesis in bacteriophage T4: the transversion pathway.
abstract: Heat induces transversions (as well as transitions) at G-C base pairs in bacteriophage T4. The target base for transversions is guanine,which is converted to a product which is sometimes replicated and transcribed as a pyrimidine.A model for this process is proposed in which the deoxyguanosine glycosidic bond migrates from N9 to N2: the resulting deoxyneoguanosine may pair with normal guanine to produce G-C leads to C-G transversions.
mesh_terms: D001483:Base Sequence; D003090:Coliphages; D006150:Guanine Nucleotides; D006358:Hot Temperature; D006860:Hydrogen Bonding; D007700:Kinetics; D009154:Mutation
chemical_list: D006150:Guanine Nucleotides