Clinical trial of the beta-adrenoreceptor-blocking agent tolamolol with the use of 24 hour blood pressure recordings.
1. The average blood pressure over 24 h and its variability were measured in eight unrestricted subjects before and after commencing therapy with a new beta-adrenoreceptor-blocking agent, tolamolol. 2. The drug caused a fall of 15 +/- 6 mgHg in mean arterial pressure and heart rate fell by 13 beats/min. The variation in blood pressure and heart rate over 24 h was unchanged after treatment.
D000328:Adult; D001794:Blood Pressure / Q000187:drug effects*; D003864:Depression, Chemical; D005260:Female; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D006973:Hypertension / Q000188:drug therapy; D008297:Male; D008875:Middle Aged; D011412:Propanolamines / Q000627:therapeutic use*; D013997:Time Factors
D011412:Propanolamines