title: [Acute myeloid leukemia following treatment of IgA-paraproteinemia with alkeran].
abstract: Report on a 74-year-old patient who developed acute myeloid leukemia 16 months after diagnosis of IgA paraproteinemia. He had received a total dose of 1.4-1.5 g melphalan. The possible etiologic role of melphalan in the development of acute leukemia is discussed.
mesh_terms: D000368:Aged; D001796:Blood Protein Disorders / Q000188:drug therapy*; D001797:Blood Protein Electrophoresis; D006801:Humans; D007070:Immunoglobulin A; D015470:Leukemia, Myeloid, Acute / Q000139:chemically induced*; D008297:Male; D008558:Melphalan / Q000008:administration & dosage / Q000009:adverse effects* / Q000627:therapeutic use; D013997:Time Factors
chemical_list: D007070:Immunoglobulin A; D008558:Melphalan
vernacular_title: Akute myeloische Leukämie nach Alkeran-Therapie einer IgA-Paraproteinämie