Salmonella meningitis treatment with intravenous trimethoprim.
Intravenous trimethoprim and sulphadiazine were used in the successful treatment of Salmonella meningitis in a four months old child. Pharmacological data are presented which show good penetration of the bloodbrain barrier by trimethoprim. This combination appears to be a useful alternative therapy for gram-negative meningitis.
D004359:Drug Therapy, Combination; D006801:Humans; D007223:Infant; D007275:Injections, Intravenous; D008297:Male; D008581:Meningitis / Q000188:drug therapy*; D012480:Salmonella Infections / Q000188:drug therapy*; D013411:Sulfadiazine / Q000008:administration & dosage / Q000627:therapeutic use; D014295:Trimethoprim / Q000008:administration & dosage* / Q000627:therapeutic use
D013411:Sulfadiazine; D014295:Trimethoprim