title: [Differential diagnosis of chronic myeloic leucemia in infancy (author's transl)].
abstract: A 3 months old girl presented with significant enlargement of liver, spleen and lymphnodes, with moderate anemia, thrombopenia and leucocytosis. In the differential count there was a shift to the left and an increase of monocyte-like cells (35%). Differential diagnosis included leucemoid reaction, infectious mononucleosis, myelo-proliferative disorder with a missing C chromosome and chronic myeloid leucemia. Clinical symptoms, cytochemistry and caryotype of bone marrow cells suggested infantile chronic myeloic leucemia and normal ALP index and possibly normal HbF. Treatment with 6-mercaptopurine was followed by partial remission. The therapeutic consequences of exact differential diagnosis are discussed.
mesh_terms: D000740:Anemia / Q000150:complications; D002869:Chromosome Aberrations / Q000175:diagnosis; D025063:Chromosome Disorders; D003937:Diagnosis, Differential; D006801:Humans; D066298:In Vitro Techniques; D007223:Infant; D007244:Infectious Mononucleosis / Q000175:diagnosis; D007951:Leukemia, Myeloid / Q000175:diagnosis* / Q000188:drug therapy; D007964:Leukocytosis / Q000150:complications; D008107:Liver Diseases / Q000150:complications; D008206:Lymphatic Diseases / Q000150:complications; D015122:Mercaptopurine / Q000627:therapeutic use; D009196:Myeloproliferative Disorders / Q000175:diagnosis; D013158:Splenic Diseases / Q000150:complications; D013921:Thrombocytopenia / Q000150:complications
chemical_list: D015122:Mercaptopurine
vernacular_title: Zur Differentialdiagnose der chronischen myeloischen Leukämie im Säuglingsalter