Effects of anti-inflammatory steroids on mouse embryonic movements during palatal development.
The frequency of spontaneous embryonic muscular movements was recorded for embryos from mice treated with cortisone or triamcinolone. Movement was significantly reduced in A/J strain mouse embryos exposed to these anti-inflammatory agents. Cleft palates induced by the drugs may originate from failure of the embryonic tongue to be withdrawn from between the palatine shelves.
D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology*; D003348:Cortisone / Q000494:pharmacology*; D004622:Embryo, Mammalian / Q000502:physiology*; D051379:Mice; D008810:Mice, Inbred C57BL / Q000196:embryology; D008815:Mice, Inbred Strains / Q000196:embryology; D009068:Movement; D010159:Palate / Q000196:embryology*; D014221:Triamcinolone / Q000494:pharmacology*
D000893:Anti-Inflammatory Agents; D014221:Triamcinolone; D003348:Cortisone