The metabolism of estradiol by perfused livers and liver slices of normal and cirrhotic rats.
The metabolism of estradiol- 17 beta and cirrhotic (CC14 -induced) rat livers was studied in isolated perfused livers and in incubations of liver slices. In these experiments the cirrhotic livers show a reduced clearance of estradiol, an accumulation of extractable metabolites and a delayed transformation to non-extractable metabolites. It is concluded that these changes in the metabolism of estradiol are caused not only by an altered circulation of the blood through intrahepatic shunts, but also by disturbances in the uptake and/or metabolism of the estrogens by the liver cells.
D000818:Animals; D046508:Culture Techniques; D004958:Estradiol / Q000378:metabolism*; D004967:Estrogens / Q000378:metabolism; D004970:Estrone / Q000378:metabolism; D008099:Liver / Q000378:metabolism*; D008106:Liver Cirrhosis, Experimental / Q000378:metabolism*; D008297:Male; D008657:Metabolic Clearance Rate; D010477:Perfusion; D051381:Rats; D011919:Rats, Inbred Strains; D013997:Time Factors
D004967:Estrogens; D004970:Estrone; D004958:Estradiol