Plasma noradrenaline and renovascular hypertension in the rat.
1. Plasma noradrenaline was measured in groups of rats up to 4 weeks after application of a renal artery clip. 2. When renal artery clipping was accoumpanied by contralateral nephrectomy (one-kidney model) plasma noradrenaline was significantly higher in hypertensive rats than in sham-operated control rats at 7, 14 and 28 days. 3. Plasma noradrenaline was not altered at any time examined in the two-kidney model (unilateral clip and contralateral kidney left in situ). 4. Neurogenic mechanisms mediated by the peripheral sympathetic nervous system appear to participate in the development of one-kidney renovascular hypertension, but do not play a significant role in the two-kidney model.
D000818:Animals; D006977:Hypertension, Renal / Q000097:blood* / Q000503:physiopathology; D008297:Male; D009392:Nephrectomy; D009638:Norepinephrine / Q000097:blood*; D051381:Rats; D013564:Sympathetic Nervous System / Q000503:physiopathology
D009638:Norepinephrine