[Dose-response relationship of repeated injections of pentagastrin on the vagally innervated rat stomach in perfusion experiments].
In the perfusion model under urethane anesthesia Wistar rats were two times injected pentagastrin subcutaneously in a distance of 150 minutes in dose rates of 50, 100, 150, 200, 250 and 300 microgram/kg b. w. The results may be summarized as follows: 1. The dose of 200 microgram/kg b. w. of pentagastrin produced the maximal answer. Higher doses showed a diminished acid secretion. 2. The diminished effect of higher doses of gastrin may be caused by a hypothetical inhibitor which may be more effective after truncal vagotomy. 3. The repeated injection of pentagastrin did not show a significant difference of the answer. The second injection was given after the acid secretion has returned to the basal level. No tachyphylaxy was seen under these conditions.
D000818:Animals; D004305:Dose-Response Relationship, Drug; D005750:Gastric Juice / Q000378:metabolism; D007279:Injections, Subcutaneous; D008297:Male; D010418:Pentagastrin / Q000494:pharmacology*; D010477:Perfusion; D051381:Rats; D013270:Stomach / Q000187:drug effects* / Q000294:innervation; D013618:Tachyphylaxis; D013997:Time Factors; D014630:Vagus Nerve / Q000502:physiology
D010418:Pentagastrin
Dosiswirkungsbeziehungen einer wiederholten Injektion von Pentagastrin am vagal innervierten Rattenmagen in Perfusionsversuch.