title: Motilin effects on gastrointestinal motility and lower esophageal sphincter (LES) pressure in dogs.
abstract: Natural porcine motilin induces phasic contractions of the lower esophageal sphincter in dogs. These contractions are related to gastric contractions, which have the characteristics of interdigestive-motility patterns. Duodenal alkalinization produces an insignificant LES pressure increase after 5 minutes. No effect of motilin was observed when using isolated canine muscle strips.
mesh_terms: D000818:Animals; D004285:Dogs; D004943:Esophagogastric Junction / Q000187:drug effects* / Q000502:physiology; D005260:Female; D005768:Gastrointestinal Hormones / Q000494:pharmacology*; D005769:Gastrointestinal Motility / Q000187:drug effects*; D008297:Male; D009037:Motilin / Q000494:pharmacology*; D009119:Muscle Contraction / Q000187:drug effects; D011312:Pressure; D013268:Stimulation, Chemical; D014325:Tromethamine / Q000494:pharmacology
chemical_list: D005768:Gastrointestinal Hormones; D014325:Tromethamine; D009037:Motilin