Experience with a Dutch kveim suspension in men and guinea pigs.
A Kveim antigen was prepared according to the Chase-Siltzbach method from the spleen of a patient with sarcoidosis. This antigen was tested in a number of patients with sarcoidosis or possible sarcoidosis and also in a number of non-sarcoid patients. Several lots prepared from this spleen were compared, yielding differences in reactogenicity. Maybe this can be explained by heterogeneity of the spleen. An animal model (the BCG-presensitized guinea pig) is presented that may be applicable for a preclinical evaluation of lots of Kveim antigen.
D000293:Adolescent; D000818:Animals; D000941:Antigens; D004195:Disease Models, Animal; D006168:Guinea Pigs; D006801:Humans; D007731:Kveim Test; D008297:Male; D009426:Netherlands; D012507:Sarcoidosis / Q000276:immunology; D012882:Skin Tests
D000941:Antigens