Hypodiploidy and cellular survival.
Cytogenetic study of bone marrow cells in a child with acute lymphocytic leukemia showed a 27 chromosomes cell-line. Only four pairs appeared to be normal (X, 10, 18, 21). All the others were haploid. This strong hypodiploidy seems to be compatible with the survival and proliferation of these abnormal cells.
D002455:Cell Division; D002470:Cell Survival; D002675:Child, Preschool; D002869:Chromosome Aberrations; D002900:Chromosomes, Human, 1-3; D002901:Chromosomes, Human, 13-15; D002902:Chromosomes, Human, 16-18; D002903:Chromosomes, Human, 19-20; D002904:Chromosomes, Human, 21-22 and Y; D002905:Chromosomes, Human, 4-5; D002906:Chromosomes, Human, 6-12 and X; D005260:Female; D005815:Genetic Code; D006238:Haploidy; D006801:Humans; D007621:Karyotyping; D007945:Leukemia, Lymphoid / Q000235:genetics*