[ANT(4')I: a new aminoglycoside nucleotidyltransferase found in "staphylococcus aureus" (author's transl)].
A new nucleotidyltransferase has been obtained from clinical isolates of kanamycin, amikacin, tobramycin, neomycin and lividomycin resistant strains of Staphylococcus aureus. The enzyme has been purified by affinity chromatography then characterized in a kinetic and physicochemical point of view. The results obtained support that the target of this enzyme is the 4'-hydroxyl group of a number of aminoglycosides. We propose to call it ANT(4')I.
D000617:Aminoglycosides / Q000378:metabolism / Q000494:pharmacology; D000900:Anti-Bacterial Agents / Q000378:metabolism / Q000494:pharmacology; D055598:Chemical Phenomena; D002621:Chemistry; D004352:Drug Resistance, Microbial; D007612:Kanamycin / Q000494:pharmacology; D009355:Neomycin / Q000494:pharmacology; D009713:Nucleotidyltransferases / Q000032:analysis / Q000302:isolation & purification / Q000378:metabolism; D010303:Paromomycin / Q000031:analogs & derivatives / Q000494:pharmacology; D013211:Staphylococcus aureus / Q000187:drug effects / Q000201:enzymology*; D014031:Tobramycin / Q000494:pharmacology
D000617:Aminoglycosides; D000900:Anti-Bacterial Agents; D007612:Kanamycin; D010303:Paromomycin; D009713:Nucleotidyltransferases; D009355:Neomycin; D014031:Tobramycin
ANT(4')I: une nouvelle nucléotidyltransférase d'aminoglycosides isolée de Staphylococcus aureus