[Conformational features of beta-lipotropic hormone and its fragments].
Structural features of porcine and bovine beta-lipotropic hormone and fragments of porcine hormone have been studied by the methods of circular dichroism and infra-red sectroscopy and by analysis of amino acid sequence. It has been established that the structure of the hormone includes a set of regular helical forms which varies considerably with the humidity and dielectric constant of the medium. The presence of left-handed helical conformations of the poly-L-proline II type in aqueous medium and moist films and their transformations with the variation of the parameters of the medium has been demonstrated. The role of the extended left-handed helical structures in hormone functions in the blood and intercellular space is discussed.
D000818:Animals; D002417:Cattle; D002942:Circular Dichroism; D010446:Peptide Fragments; D011487:Protein Conformation; D013055:Spectrophotometry, Infrared; D013552:Swine; D008083:beta-Lipotropin
D010446:Peptide Fragments; D008083:beta-Lipotropin
Konformatsinnye osobennosti beta-lipotropnogo gormona i ego fragmentov.