Leukemic urate nephropathy.
The tubules appear to be the primary sites of injury in renal failure and urate nephropathy associated with leukemia. Tubular injury is not always associated with precipitation and phagocytosis of crystals, except in the collecting tubules where cellular changes are invariably caused by intraluminal crystallization of urates. The electron microscopical observations in this communication may apply to the urate nephropathy associated with hyperuricemia of various causes.
D001485:Basement Membrane / Q000473:pathology; D002648:Child; D003460:Crystallization; D003594:Cytoplasmic Granules / Q000648:ultrastructure; D004847:Epithelial Cells; D004848:Epithelium / Q000648:ultrastructure; D006644:Histiocytes / Q000648:ultrastructure; D006801:Humans; D007668:Kidney / Q000473:pathology*; D007674:Kidney Diseases / Q000209:etiology / Q000378:metabolism / Q000473:pathology*; D007678:Kidney Glomerulus / Q000473:pathology / Q000648:ultrastructure; D007684:Kidney Tubules / Q000473:pathology; D007687:Kidney Tubules, Proximal / Q000648:ultrastructure; D007945:Leukemia, Lymphoid / Q000097:blood / Q000150:complications / Q000473:pathology*; D008297:Male; D010587:Phagocytosis; D014527:Uric Acid / Q000097:blood / Q000378:metabolism*
D014527:Uric Acid