title: Antimalarial drugs and reduced incidence of dental plaque.
abstract: Known antimalarial compunds from several chemical classes were tested for their ability to inhibit in vitro growth of microorganisms causing dental plaque and to prevent the development of plaque in a hamster model. Approximately a third of the compounds tested inhibited in vitro growth; however, none prevented development of plaque.
mesh_terms: D000190:Actinomyces / Q000187:drug effects / Q000254:growth & development; D000655:Amodiaquine / Q000494:pharmacology; D000818:Animals; D000962:Antimalarials / Q000494:pharmacology*; D002478:Cells, Cultured; D002738:Chloroquine / Q000494:pharmacology; D006224:Cricetinae; D003622:Dapsone / Q000494:pharmacology; D003773:Dental Plaque / Q000378:metabolism / Q000382:microbiology / Q000517:prevention & control*; D008297:Male; D011319:Primaquine / Q000494:pharmacology; D011739:Pyrimethamine / Q000494:pharmacology; D011803:Quinine / Q000494:pharmacology; D013291:Streptococcus / Q000187:drug effects / Q000254:growth & development; D013415:Sulfalene / Q000494:pharmacology; D013752:Tetracycline / Q000494:pharmacology; D014295:Trimethoprim / Q000494:pharmacology
chemical_list: D000962:Antimalarials; D000655:Amodiaquine; D002738:Chloroquine; D003622:Dapsone; D011803:Quinine; D014295:Trimethoprim; D013752:Tetracycline; D011319:Primaquine; D013415:Sulfalene; D011739:Pyrimethamine