Histocompatibility of polyvinyl acetate, an ingredient of chewing gum.
The histocompatibility of polyvinyl acetate (PVA), an ingredient of chewing gum, was evaluated from both a direct irritant (toxic reaction) and an allergic (antigen-antibody) standpoint. Subcutaneous injections in rats and topical application of hamster pouches were utilized. Polyvinyl acetate was shown to cause a moderate to severe inflammatory reaction when injected subcutaneously, which peaked at day 7 and was minimal at day 42. The histologic appearance of the hamster cheek pouch was not significantly altered by the PVA. Although PVA has been used as a plasticizer in chewing gum, it was not possible to induce any histologic changes in tissues which resembled the specific changes present in atypical gingivostomatitis (plasma-cell gingivostomatitis).
D000085:Acetates / Q000008:administration & dosage / Q000276:immunology; D000287:Administration, Topical; D000485:Allergens; D000818:Animals; D002351:Carrageenan; D002638:Chewing Gum; D006224:Cricetinae; D006099:Granuloma / Q000139:chemically induced / Q000473:pathology; D007279:Injections, Subcutaneous; D008647:Mesocricetus; D011145:Polyvinyls / Q000008:administration & dosage / Q000276:immunology*; D051381:Rats
D000085:Acetates; D000485:Allergens; D002638:Chewing Gum; D011145:Polyvinyls; C013215:polyvinyl acetate; D002351:Carrageenan