Acute lymphoblastic leukaemia after treatment of nephrotic syndrome with immunosuppressive drugs.
The authors present a 4-year-old girl with nephrotic syndrome who developed actue lymphoblastic leukaemia 5 months after the start of a combined treatment of alternate day prednisone and daily cyclophosphamide during 3 months. The nephrotic syndrome was due to focal segmental glomerulosclerosis. The occurrence of leukaemia might be related to the preceeding treatment with cyclophosphamide.
D000208:Acute Disease; D002675:Child, Preschool; D003520:Cyclophosphamide / Q000009:adverse effects* / Q000627:therapeutic use; D004359:Drug Therapy, Combination; D005260:Female; D006098:Granulocytes; D006801:Humans; D007945:Leukemia, Lymphoid / Q000097:blood / Q000139:chemically induced*; D007958:Leukocyte Count; D009404:Nephrotic Syndrome / Q000188:drug therapy*; D011241:Prednisone / Q000009:adverse effects* / Q000627:therapeutic use
D003520:Cyclophosphamide; D011241:Prednisone