title: [Liver-damaging action of halothane--an animal experiment study].
abstract: After long-term exhibition to halothane (up to 96 hours), centrolobular hepatic damage (fatty degeneration, necrobiosis and necrosis) developed in rats, proportionally to the number of anesthesias and shortening of the intervals. From these results no hepatotoxic effect of halothane can be derived, since the alterations might be caused by hypoxia alone.
mesh_terms: D000818:Animals; D001654:Bile Pigments / Q000032:analysis; D002455:Cell Division / Q000187:drug effects; D056486:Chemical and Drug Induced Liver Injury; D004305:Dose-Response Relationship, Drug; D005234:Fatty Liver / Q000139:chemically induced; D005260:Female; D006221:Halothane / Q000009:adverse effects*; D000860:Hypoxia / Q000503:physiopathology; D008099:Liver / Q000187:drug effects* / Q000473:pathology; D009336:Necrosis / Q000139:chemically induced; D051381:Rats; D013997:Time Factors
chemical_list: D001654:Bile Pigments; D006221:Halothane
vernacular_title: Zur Frage der leberschädigenden Wirkung des Halothan--ein tierexperimenteller Beitrag.