Leukaemic transformation of f1-hybrid cells after inoculation of parental leukaemic cells.
An aneuploid chromosomal anomaly was observed in more than 90% of the mitoses of a spontaneous acute lymphatic leukaemia in C57BL/6J mice preserved by passage in the strain of origin since 1967. The leukaemia is strain-specific and causes the death of its recipients within 9 days. After repeated transfers within F1-hybrids tagged with the T6-marker chromosome, mitoses containing both the chromosomal anomaly of the leukaemic cells and the T6-marker of the semiallogeneic host were observed. This evidence of malignant transformation is compared to leukaemic transformation as observed after clinical bone marrow transplantation.
D000818:Animals; D002471:Cell Transformation, Neoplastic; D002869:Chromosome Aberrations / Q000150:complications; D025063:Chromosome Disorders; D005260:Female; D006824:Hybridization, Genetic; D007938:Leukemia / Q000473:pathology*; D007942:Leukemia, Experimental / Q000473:pathology; D007945:Leukemia, Lymphoid / Q000150:complications / Q000473:pathology; D007962:Leukocytes; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D008938:Mitosis; D009368:Neoplasm Transplantation; D013997:Time Factors