Macrophage mediated tumor cell cytotoxicity.
The following evidence from our research has implicated the macrophage as an important effector cell in pyran and/or C. parvum induced host resistance to solid tumors: (1) Increased infiltration of tumors with histiocytes following systemic treatment with pyran;17 (2) activated peritoneal macrophages with tumoricidal activity have been recovered from the peritoneal cavity of normal or tumor bearing mice treated with pyran or C. parvum;17 (3) activated peritoneal macrophages mixed with tumor cells in vitro and transplanted into syngeneic recipients inhibited tumor growth; (4) trypan blue, an inhibitor of macrophage function, prevent C. parvum induced regression of methylcholanthrene tumors; and (5) direct intralesional injection of activated macrophages into the MCA 2182 tumor inhibited tumor growth and increased the MST.
D000818:Animals; D001202:Ascitic Fluid / Q000276:immunology; D003601:Cytotoxicity Tests, Immunologic; D005354:Fibrosarcoma; D007111:Immunity, Cellular; D008264:Macrophages / Q000187:drug effects / Q000276:immunology*; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D009374:Neoplasms, Experimental / Q000276:immunology* / Q000473:pathology; D011425:Propionibacterium acnes / Q000276:immunology; D011714:Pyrans / Q000494:pharmacology; D012513:Sarcoma, Experimental / Q000276:immunology; D014343:Trypan Blue / Q000494:pharmacology
D011714:Pyrans; D014343:Trypan Blue