D-amphetamine disaggregates brain polysomes via a dopaminergic mechanism.
Brain polysomes are disaggregated in rats given moderate to large doses of d-amphetamine sulfate; this response is rapid in onset, lasts for at least 4-6 hr, and varies with the age of the animal. Pretreatment with a dopamine receptor blocking agent, haloperidol or pimozide, blocks the amphetamine-induced disaggregation.
D000818:Animals; D001921:Brain / Q000378:metabolism / Q000648:ultrastructure*; D003913:Dextroamphetamine / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D004298:Dopamine / Q000378:metabolism*; D006220:Haloperidol / Q000494:pharmacology; D008297:Male; D010868:Pimozide / Q000494:pharmacology; D011132:Polyribosomes / Q000187:drug effects*; D051381:Rats; D011955:Receptors, Drug
D011955:Receptors, Drug; D010868:Pimozide; D006220:Haloperidol; D003913:Dextroamphetamine; D004298:Dopamine