Acquired resistance to daunorubicin in a patient with acute myelogenous leukaemia.
Measurement of in vitro and in vivo resistance to daunorubicin in AML patients suggests that there is no simple correlation between the two. In a patient who became clinically resistant and whose cells showed a parallel increased resistance in vitro we found the acquisition of multiple drug resistance. The increased in vitro resistance to daunorubicin could to some extent be overcome by conjugating daunorubicin to DNA.
D002478:Cells, Cultured; D004247:DNA; D003630:Daunorubicin / Q000627:therapeutic use*; D004351:Drug Resistance; D006801:Humans; D066298:In Vitro Techniques; D015470:Leukemia, Myeloid, Acute / Q000188:drug therapy*; D007958:Leukocyte Count; D013997:Time Factors
D004247:DNA; D003630:Daunorubicin