Study of leukocyte kinetics in acute myelocytic leukemia utilizing chromium-51.
Leukocyte kinetic studies using chromium-51 were performed in four patients with acute myelocytic leukemia (AML). Intravascular leukocyte survival was prolonged in comparision with granulocyte survival in normal subjects. Significant splenic pooling occurred in three patients, none of whom had splenomegaly. In one patient studied, circulating leukemic cells were shown to return to the bone marrow. The prolongation of intravascular leukocyte survival in AML in relapse, as in chronic myelocytic leukemia, probably depends on several factors including the presence of immature leukemic cells and the recycling of these cells from the spleen and bone marrow.
D000328:Adult; D001854:Bone Marrow Cells; D002470:Cell Survival; D002860:Chromium Radioisotopes; D005260:Female; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000097:blood*; D007958:Leukocyte Count; D007962:Leukocytes; D008297:Male; D008875:Middle Aged; D011877:Radionuclide Imaging
D002860:Chromium Radioisotopes