title: X-ray crystallographic visualization of drug-nucleic acid intercalative binding: structure of an ethidium-dinucleoside monophosphate crystalline complex, Ethidium: 5-iodouridylyl (3'-5') adenosine.
abstract: We have cocrystallized the drug ethidium bromide with the dinucleoside monophosphate 5-iodouridylyl(3'-5')adenosine and have solved the three-dimensional structure to atomic resolution by x-ray crystallography. This has allowed the direct visualization of intercalative binding by this drug to a fragment of a nucleic acid double helix.
mesh_terms: D000227:Adenine Nucleotides / Q000378:metabolism; D001665:Binding Sites; D004996:Ethidium / Q000378:metabolism; D008961:Models, Structural; D008968:Molecular Conformation; D014498:Uracil / Q000031:analogs & derivatives; D014500:Uracil Nucleotides / Q000378:metabolism; D014961:X-Ray Diffraction
chemical_list: D000227:Adenine Nucleotides; D014500:Uracil Nucleotides; D014498:Uracil; D004996:Ethidium