Interaction of bile with erythromycin Lactobionate in vitro.
An interaction of bile with erythromycin lactobionate in vitro has been demonstrated. The major bile components involved in this interaction have been shown to be the bile salts. The nature of the bile salt-erythromycin interaction has been investigated. The way in which an interaction between bile salts and erythromycin in vivo might lead to the hepatic dysfunction and cholestasis associated with some instances of erythromycin therapy is discussed.
D001646:Bile; D055598:Chemical Phenomena; D002621:Chemistry; D002779:Cholestasis / Q000139:chemically induced; D004187:Disaccharides; D004655:Emulsions; D004912:Erythrocytes / Q000187:drug effects; D004917:Erythromycin / Q000009:adverse effects / Q000031:analogs & derivatives* / Q000494:pharmacology; D006000:Glycocholic Acid / Q000494:pharmacology; D006801:Humans; D066298:In Vitro Techniques; D000432:Methanol; D012965:Sodium Chloride; D013500:Surface Tension; D013656:Taurocholic Acid
D004187:Disaccharides; D004655:Emulsions; D012965:Sodium Chloride; D013656:Taurocholic Acid; D004917:Erythromycin; D006000:Glycocholic Acid; D000432:Methanol