Renin inhibitory effect of synthetic phosphorylethanolamine (PE-104) in the rat.
1. The renin inhibitory effect of 2-[4-(4'-chlorophenoxy)phenoxy - acetylamino]ethylphosphoryl-ethanolamine (PE-104) was examined both in vitro and in vivo. 2. PE-104 inhibited the rate of angiotensin formation from dog renin and renin substrate reaction. The Ki value was 2 mmol/l and the inhibition was competitive. 3. In normotensive rats, infusion of PE-104 abolished the increases of blood pressure and plasma angiotensin I concentration due to renin injection. In renal hypertensive rats, infusion of PE-104 decreased blood pressure and this was associated with a decrease of plasma angiotensin I concentration. 4. These observations confirm that PE-104 is a renin inhibitor.
D000804:Angiotensin II / Q000097:blood; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D004983:Ethanolamines / Q000494:pharmacology*; D006977:Hypertension, Renal / Q000097:blood; D066298:In Vitro Techniques; D051381:Rats; D012083:Renin / Q000097:blood; D000092502:Renin Inhibitors
D000804:Angiotensin II; D004983:Ethanolamines; D012083:Renin; D000092502:Renin Inhibitors