X-ray fiber diffraction evidence for neighbor exclusion binding of a platinum metallointercalation reagent to DNA.
Good quality x-ray diffraction patterns have been obtained of polycrystalline fibers containing 2-hydroxyethanethiolato(2,2'2"-terpyridine)platinum(II) bound to calf thymus DNA by intercalation. The photographs strongly support the neighbor exclusion binding model in which electron-dense platinum atoms are regularly distributed at 10.2 A intervals, every other interbase pair site.
D000818:Animals; D001665:Binding Sites; D002417:Cattle; D004247:DNA; D008623:Mercaptoethanol / Q000031:analogs & derivatives; D008958:Models, Molecular; D008968:Molecular Conformation; D009690:Nucleic Acid Conformation; D009942:Organometallic Compounds; D010984:Platinum; D011725:Pyridines; D013950:Thymus Gland; D014961:X-Ray Diffraction
D009942:Organometallic Compounds; D011725:Pyridines; D010984:Platinum; D008623:Mercaptoethanol; D004247:DNA