title: Cytotoxic antibody complicating platelet support in acute leukemia. Response to chemotherapy.
abstract: Lymphocytotoxic or thrombocytolytic antibodies were detected in 11 of 25 thrombocytopenic patients receiving repeated platelet transfusions. Platelet survival times were reduced in these patients (half-life [T/2], 32 hours) as compared to patients without antibody (T/2, 51 hours, P less than .05). In one woman with acute myeloblastic leukemia and a potent platelet antibody, combination chemotherapy resulted in a profound decrease in circulating gamma-globulin and concurrent disappearance of the cytotoxic antibody. The survival of transfused platelets in this patient was dramatically improved, and bleeding was controlled.
mesh_terms: D000293:Adolescent; D000328:Adult; D001792:Blood Platelets / Q000276:immunology*; D001803:Blood Transfusion; D003601:Cytotoxicity Tests, Immunologic; D005260:Female; D006680:HLA Antigens; D006650:Histocompatibility Testing; D006801:Humans; D007518:Isoantibodies / Q000032:analysis*; D007951:Leukemia, Myeloid / Q000276:immunology* / Q000628:therapy; D008214:Lymphocytes / Q000276:immunology; D008875:Middle Aged; D013921:Thrombocytopenia / Q000628:therapy
chemical_list: D006680:HLA Antigens; D007518:Isoantibodies