Neutrophil dysfunction and granulomatosis in the preleukemic state.
A 40-year-old male had periods of fever, sore throat and anemia for 14 months before acute myeloblastic leukemia could be diagnosed from hematological findings. During the preleukemic state, impaired bactericidal capacity of the granulocytes was repeatedly demonstrated and multiple hepatosplenic and skin granulomas occurred. Results of granulocyte function studies may prove to be of significant aid in the diagnosis of the preleukemic state of acute myeloblastic leukemia.
D000328:Adult; D006105:Granulomatous Disease, Chronic / Q000209:etiology; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000150:complications* / Q000175:diagnosis; D008107:Liver Diseases / Q000209:etiology; D008297:Male; D009504:Neutrophils; D010585:Phagocyte Bactericidal Dysfunction / Q000209:etiology*; D012871:Skin Diseases / Q000378:metabolism; D013158:Splenic Diseases / Q000378:metabolism