In vivo behavior of a Sindbis virus mutant isolated from persistently infected Aedes aegypti cell cultures.
A mutant of the Sindbis virus SV-S was found to interfere with the regular course of infection by the wild strain of the virus SV-W in A. aegypti mosquitoes and in suckling mice. In mosquitoes, this result was manifested by a reduced titer of SV-W in the presence of SV-S and by a failure of the mosquitoes to transmit SV-W. In the brains of suckling mice, in the presence of SV-S, the growth of sc inoculated SV-W was suppressed, and as a result, the usually lethal course of infection by this virus was converted into a nonlethal one.
D000330:Aedes / Q000382:microbiology* / Q000502:physiology; D000818:Animals; D001102:Arbovirus Infections / Q000382:microbiology; D002478:Cells, Cultured; D005247:Feeding Behavior; D007303:Insect Vectors; D051379:Mice; D009154:Mutation; D012845:Sindbis Virus / Q000254:growth & development* / Q000302:isolation & purification; D014762:Viral Interference; D014774:Virulence