Oxalate excretion during carbohydrate infusions.
Oxalate metabolism was assessed in normal rats and rats deficient in vitamins B-1 and B-6 during intravenous infusions of solutions containing glucose, fructose, sorbitol or xylitol. Urinary excretions of oxalate, glyoxylate and glycine were considerably increased in vitamin B-6 deficient rats infused with xylitol. Significant amounts of 14C-oxalate were excreted only in vitamin B-6 deficient rats infused with U 14C-xylitol. Correction of vitamin B-6 deficiency resulted in a return to normal of urinary oxalate excretion and percentage of U 14C-xylitol excreted as 14C-oxalate. The results suggest that xylitol metabolism produces an increased activity in pathways leading to oxalate formation in vitamin B-6 deficient rats.
D000818:Animals; D003404:Creatinine / Q000652:urine; D005632:Fructose / Q000494:pharmacology; D005947:Glucose / Q000494:pharmacology; D005998:Glycine / Q000652:urine; D006038:Glyoxylates / Q000652:urine; D006601:Hexoses / Q000494:pharmacology*; D006801:Humans; D007263:Infusions, Parenteral; D008297:Male; D010070:Oxalates / Q000652:urine*; D051381:Rats; D013012:Sorbitol / Q000494:pharmacology; D013402:Sugar Alcohols / Q000494:pharmacology*; D013832:Thiamine Deficiency / Q000378:metabolism*; D026681:Vitamin B 6 Deficiency / Q000378:metabolism*; D014993:Xylitol / Q000494:pharmacology
D006038:Glyoxylates; D006601:Hexoses; D010070:Oxalates; D013402:Sugar Alcohols; D005632:Fructose; D013012:Sorbitol; D003404:Creatinine; D005947:Glucose; D005998:Glycine; D014993:Xylitol