Syntheses of motilin analogues.
According to a first suggestion for the primary structure of the gastrointestinal hormone motilin, two analogues containing norleucine and leucine instead of methionine in the sequence position 13 (primarily called 13-norleucine and 13-leucine-motilin) have been synthesized. Both synthetic peptides were biologically active in equivalence to the natural product. A correction of the proposed amino acid sequence became necessary after rechecking the results by comparison with the synthetic materials. The two analogues must therefore correctly be named 13-norleucine-14-desamidomotilin and 13-leucine-14-desamido-motilin.
D000595:Amino Acid Sequence; D002852:Chromatography, Ion Exchange; D005768:Gastrointestinal Hormones / Q000138:chemical synthesis*; D007930:Leucine; D008715:Methionine; D009037:Motilin / Q000031:analogs & derivatives / Q000032:analysis / Q000138:chemical synthesis*; D009646:Norleucine
D005768:Gastrointestinal Hormones; D009037:Motilin; D009646:Norleucine; D008715:Methionine; D007930:Leucine