title: The mechanism of replication of adenovirus type 5 DNA.
abstract: The analysis of replicating Ad5 DNA has led to a model for replication involving linear intermediates. The origin of replication has been localized at the molecular right end, suggesting the presence of a unique sequence of nucleotides which can be recognized by an initiation factor. On the other hand, the study of the molecular ends has shown, so far, a high degree of symmetry in the terminal nucleotide sequences of Ad5 DNA. A more detailed study of the nucleotide sequences at the ends is necessary to solve this problem.
mesh_terms: D000256:Adenoviridae / Q000378:metabolism*; D001483:Base Sequence; D002460:Cell Line; D002467:Cell Nucleus / Q000378:metabolism; D002874:Chromosome Mapping; D003588:Cytopathogenic Effect, Viral; D004261:DNA Replication / Q000187:drug effects; D004262:DNA Restriction Enzymes; D004279:DNA, Viral / Q000032:analysis / Q000096:biosynthesis*; D003854:Deoxyribonucleotides / Q000032:analysis; D003864:Depression, Chemical; D006918:Hydroxyurea / Q000494:pharmacology; D007700:Kinetics; D008970:Molecular Weight; D009690:Nucleic Acid Conformation
chemical_list: D004279:DNA, Viral; D003854:Deoxyribonucleotides; D004262:DNA Restriction Enzymes; D006918:Hydroxyurea