title: Opioid activity of a peptide, beta-lipotropin-(61-91), derived from beta-lipotropin.
abstract: The pituitary peptide beta-lipotropin displays essentially no opoid activity in a preparation of guinea pig ileum or in the opiate receptor binding assay. However, a fragment, beta-lipotropin-(61-91), with the enkephalin sequence (Tyr-Gly-Gly-Phe-Met) at its NH2-terminus, has typical opioid effects in these two assays.
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D001921:Brain; D006168:Guinea Pigs; D007082:Ileum / Q000187:drug effects; D066298:In Vitro Techniques; D009022:Morphine Derivatives / Q000494:pharmacology; D009419:Nerve Tissue Proteins / Q000494:pharmacology; D009842:Oligopeptides / Q000494:pharmacology*; D011955:Receptors, Drug; D013329:Structure-Activity Relationship; D008083:beta-Lipotropin / Q000494:pharmacology*
chemical_list: D009022:Morphine Derivatives; D009419:Nerve Tissue Proteins; D009842:Oligopeptides; D011955:Receptors, Drug; D008083:beta-Lipotropin