[Pyruvate and alpha-ketoglutarate levels in the after parenteral fat emulsion (Lipofundin) administration].
In various kinds of tests the metabolites pyruvate, lactate, and alpha-ketoglutarate were estimated after a single application of Lipofundin, resp. sorbitol solution. Within 24 hours after infusion significant changes of concentration occurred. The results are discussed. It is emphasized that Lipofundin caused no additional metabolic alterations compared with sorbitol, thus the concentration changes of pyruvate, lactate, and alpha-ketoglutarate after Lipofundin probably being caused by its content of sorbitol. Accordingly, parenteral application of fat during the immediate postoperative period is not necessary. After this period it is indicated in order to meet requirements of essential fatty acids and of energy.
D005217:Fat Emulsions, Intravenous / Q000008:administration & dosage / Q000494:pharmacology*; D006801:Humans; D007656:Ketoglutaric Acids / Q000097:blood*; D007773:Lactates / Q000097:blood*; D008660:Metabolism / Q000187:drug effects; D011182:Postoperative Care; D011773:Pyruvates / Q000097:blood*; D013012:Sorbitol / Q000494:pharmacology*
D005217:Fat Emulsions, Intravenous; D007656:Ketoglutaric Acids; D007773:Lactates; D011773:Pyruvates; D013012:Sorbitol
Das Verhalten von Pyruvat, und alpha-Ketoglutarat im Blut nach parenteraler Fettemulsion (Lipofundin)-Gabe.