Resetting of the baroreceptor in hypotension in rats.
1. A progressive but incomplete adaptation of the aortic baroreceptor was observed after 1 and 6 h of hypotension in rats subjected to controlled bleeding. Administration of phenoxybenzamine produced a greater downward displacement of baroreceptor activation range. 2. Complete adaptation was observed after 48 h of maintained hypotension in rats treated with reserpine. 3. The range of the aortic baroreceptor activation shifted upward as pressure returned to normotension, indicating the reversibility of baroreceptor adaptation in hypotension.
D000222:Adaptation, Physiological; D000818:Animals; D007022:Hypotension / Q000503:physiopathology*; D008297:Male; D010643:Phenoxybenzamine / Q000494:pharmacology; D011311:Pressoreceptors / Q000187:drug effects / Q000502:physiology*; D051381:Rats; D012110:Reserpine / Q000494:pharmacology; D013997:Time Factors
D010643:Phenoxybenzamine; D012110:Reserpine