The effectiveness of a synthetic vasopressin analogue as a vasoconstrictor.
The effectiveness of a synthetis vassopressin analogue, ornithine-8-vasopressin (POR-8), as a vasocontrictor was tested in the superficial vessels of the rabbit ear. When compared to a control of normal saline and a standard of a dilute solution of epinephrine in lidocaine, POR-8 in saline is more effective than POR-8 in lidocaine, and is comparable in its effectiveness to the epinephrine solution.
D000818:Animals; D001808:Blood Vessels / Q000187:drug effects*; D004431:Ear, External / Q000098:blood supply; D004837:Epinephrine / Q000494:pharmacology; D005260:Female; D008012:Lidocaine / Q000494:pharmacology; D008297:Male; D009952:Ornithine / Q000494:pharmacology; D011817:Rabbits; D014662:Vasoconstrictor Agents; D014667:Vasopressins / Q000031:analogs & derivatives* / Q000494:pharmacology
D014662:Vasoconstrictor Agents; D014667:Vasopressins; D008012:Lidocaine; D009952:Ornithine; D004837:Epinephrine