title: [Treatment of acute lymphocytic leukemia in children with combination chemotherapy and irradiation of the central nervous system].
abstract: From July 1972 until April 1975 51 children with acute lymphocytic leukemia had been treated with combination chemotherapy and central nervous system irradiation. First remission was induced in 46 patients. 13 patients died during the first and second year of treatment. Central nervous system leukemia developed only in 3 patients. In 9 patients chemotherapy had been stopped after 30 months of treatment. These results are very encouraging and we hope that majority of our patients will survive 5 years without relapse.
mesh_terms: D000293:Adolescent; D000970:Antineoplastic Agents / Q000008:administration & dosage / Q000627:therapeutic use; D002490:Central Nervous System / Q000528:radiation effects*; D002493:Central Nervous System Diseases / Q000209:etiology / Q000517:prevention & control*; D002648:Child; D002675:Child, Preschool; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D007945:Leukemia, Lymphoid / Q000150:complications / Q000188:drug therapy* / Q000532:radiotherapy; D008297:Male; D011830:Radiation Effects; D012075:Remission, Spontaneous
chemical_list: D000970:Antineoplastic Agents
vernacular_title: Akutna limfocitna leukemija u dece lecene hemioterapijom i zracenjem centralnog nervnog sistema