Human studies on the bioavailability of a quaternary ammonium compounds, tiemonium iodide and tiemonium methosulphate.
Five volunteers were administered capsules containing 14C-labelled tiemonium iodide and 4 volunteers received capsules of 14C-labelled tiemonium methosulphate. Serum, urine and faecal levels of tiemonium were measured. The percentage of the dose absorbed was determined after a further labelled intravenous injection into 3 of the volunteers. The drug appeared to be poorly absorved, as expected for quaternary ammonium compounds, but there was no difference in the bioavailability of these two tiemonium salts.
D000284:Administration, Oral; D000328:Adult; D001682:Biological Availability; D005243:Feces / Q000032:analysis; D006207:Half-Life; D006801:Humans; D007275:Injections, Intravenous; D007700:Kinetics; D008297:Male; D008875:Middle Aged; D008954:Models, Biological; D009025:Morpholines / Q000008:administration & dosage / Q000097:blood / Q000378:metabolism*; D000644:Quaternary Ammonium Compounds / Q000008:administration & dosage / Q000097:blood / Q000378:metabolism; D013876:Thiophenes / Q000008:administration & dosage / Q000097:blood / Q000378:metabolism; D013997:Time Factors
D009025:Morpholines; D000644:Quaternary Ammonium Compounds; D013876:Thiophenes