Enchancement of the antiplaque value of antibacterial agents by enamel-conditioning methods. I. Rationale, mechanism, and initial findings.
A method is proposed to induce chemically the incorporation of bacterial agents inot enamel and thus rende this tissue resistant to bacterial colonization. It consists of promoting a slight initial dissolution of enamel, followed immediately by tis reprecipitation. During this latter phase, antibacterial agents included in the test formulations would become trapped in the reprecipitating enamel. That this happens is proved by the chemical detection of antibacterial agents in treated enamel, as well as by the development of a remarkable resistance of treated specimens to grow in vitro plaque.
D000813:Anilides / Q000378:metabolism; D000818:Animals; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D001548:Benzalkonium Compounds / Q000378:metabolism; D002417:Cattle; D002614:Chelating Agents / Q000494:pharmacology*; D003743:Dental Enamel / Q000187:drug effects* / Q000378:metabolism; D003747:Dental Enamel Solubility / Q000187:drug effects; D003773:Dental Plaque / Q000382:microbiology / Q000517:prevention & control*; D003802:Dentifrices / Q000627:therapeutic use; D005459:Fluorides / Q000378:metabolism; D005650:Fumarates / Q000494:pharmacology; D006582:Hexachlorophene / Q000032:analysis / Q000378:metabolism; D010070:Oxalates / Q000494:pharmacology; D000644:Quaternary Ammonium Compounds / Q000378:metabolism; D012459:Salicylates / Q000378:metabolism; D012964:Sodium; D013053:Spectrophotometry; D013056:Spectrophotometry, Ultraviolet; D013291:Streptococcus; D014273:Triflupromazine / Q000494:pharmacology
D000813:Anilides; D000900:Anti-Bacterial Agents; D001548:Benzalkonium Compounds; D002614:Chelating Agents; D003802:Dentifrices; D005650:Fumarates; D010070:Oxalates; D000644:Quaternary Ammonium Compounds; D012459:Salicylates; D012964:Sodium; D006582:Hexachlorophene; D005459:Fluorides; D014273:Triflupromazine