Inhibition of intestinal amino acid absorption by unconjugated bile salt in vivo.
The intestinal absorption of five amino acids studied (L-lysine, L-glycine, L-leucine and L-tyrosine) and one dipeptide (glycylglycine) was significantly inhibited by the deconjugated bile salt, sodium deoxycholate, in rats in vivo. It is suggested that inhibition of absorption of amino acids and dipeptides by unconjugated bile salts may contribute to hypoproteinaemia in patients with the contaminated small-bowel syndrome.
D000596:Amino Acids / Q000378:metabolism*; D000818:Animals; D003840:Deoxycholic Acid / Q000494:pharmacology*; D003864:Depression, Chemical; D005260:Female; D006033:Glycylglycine / Q000378:metabolism; D007408:Intestinal Absorption / Q000187:drug effects*; D007583:Jejunum / Q000378:metabolism*; D051381:Rats
D000596:Amino Acids; D003840:Deoxycholic Acid; D006033:Glycylglycine