Continuous infusion of the conjunctival sac with pilocarpine in normal subjects and in patients with chronic glaucoma.
(1) A drug solution can be infused into the conjunctival sac by a simple method that does not cause overflow of solution. (2) At near neutral pH, pilocarpine infused at 1 mug/min was as effective as a single dose of 125 mug as a pupilloconstrictor in normal subjects. (3) At near neutral pH, pilocarpine infused at 10 mug/min was as effective as a single dose of 1 mg as an ocular hypotensive in cases of chronic simple glaucoma. (4) The infusion system described could find application in those situations in which it is essential to maintain a known and constant concentration of drug in the conjunctival sac.
D003228:Conjunctiva; D005901:Glaucoma / Q000188:drug therapy*; D006801:Humans; D007429:Intraocular Pressure / Q000187:drug effects; D010477:Perfusion / Q000379:methods*; D010862:Pilocarpine / Q000008:administration & dosage* / Q000627:therapeutic use
D010862:Pilocarpine