title: Three-generation Reproduction studies with FWAs.
abstract: Four fluorescent whitening agents (FWAs), compounds (1), (2), (3) and (4) (see table 1) were investigated for their effects on the reproductive performance of albino rats through 3 successive 2-litter generations at dietary levels of 40, 200, and 1000 ppm. Except for slight and random effects of compound (4) on pup survival, no adverse effects were observed. The random effects with compound (4) were not consistently related to either dose level or cumulative duration of exposure through the 3 generations.
mesh_terms: D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects; D001713:Biphenyl Compounds / Q000494:pharmacology; D001835:Body Weight / Q000187:drug effects; D004396:Coloring Agents / Q000494:pharmacology*; D005260:Female; D008297:Male; D051379:Mice; D009929:Organ Size / Q000187:drug effects; D012098:Reproduction / Q000187:drug effects*; D012726:Sexual Behavior, Animal / Q000187:drug effects; D013267:Stilbenes / Q000494:pharmacology; D014230:Triazoles / Q000494:pharmacology
chemical_list: D001713:Biphenyl Compounds; D004396:Coloring Agents; D013267:Stilbenes; D014230:Triazoles