Vascular lesions in hypertensive rats under salt loading: kidney renin and lysosomal enzymes.
1. Renal and cerebral vascular lesions occurred more often and earlier in spontaneously hypertensive rats (SHR) given a high salt diet than in SHR given a normal diet. 2. Kidney renin activity was low during high salt loading; the kidney renin activity of rats with hypertensive renal vascular lesions was moderately elevated. Kidney renin activity or cathepsin D activities were higher in stroke-prone SHR (SHRSP) aged 9 months than in stroke-resistant SHR (SHRSR). 3. beta-Glucuronidase, cathepsin D and deoxyribonuclease activities were greater in the kidney of Wistar/Kyoto (WK) rats or SHR when there were hypertensive vascular lesions. These three enzyme activities were also greater in the aorta of SHR aged 13-14 months than in the aorta of WK rats. 4. It was supposed that kidney renin activity and lysosomal enzyme activities were related to hypertensive vascular lesions.
D000818:Animals; D002543:Cerebral Hemorrhage / Q000473:pathology; D005260:Female; D006973:Hypertension / Q000473:pathology*; D007668:Kidney / Q000201:enzymology*; D008247:Lysosomes / Q000201:enzymology; D008297:Male; D008638:Mesenteric Arteries / Q000473:pathology; D051381:Rats; D012077:Renal Artery / Q000473:pathology; D012082:Renal Veins / Q000473:pathology; D012083:Renin / Q000032:analysis*; D012965:Sodium Chloride / Q000494:pharmacology
D012965:Sodium Chloride; D012083:Renin