Pancreatic carcinoma as a sequel to therapy of lymphoma.
Development of a carcinoma in the pancreas of a young man who had five years previously undergone intensive radiotherapy and subsequent chemotherapy for treatment of a lymphoma suggests that induction of the second neoplasm occurred as the result of the therapy of the first. While definite proof of causality is lacking, a review of recent literature strongly suggests that the association noted in the patient described is more than serendipitous. Increased usage of high-dose radiotherapy, particularly in conjunction with chemotherapy, may be directly related, and it is imperative that such an association be kept in mind when such patients are seen in follow-up.
D000230:Adenocarcinoma / Q000139:chemically induced / Q000209:etiology; D000293:Adolescent; D000328:Adult; D000970:Antineoplastic Agents / Q000009:adverse effects*; D002330:Carmustine / Q000009:adverse effects; D003520:Cyclophosphamide / Q000009:adverse effects; D005260:Female; D006689:Hodgkin Disease / Q000532:radiotherapy; D006801:Humans; D007945:Leukemia, Lymphoid / Q000188:drug therapy / Q000532:radiotherapy; D008228:Lymphoma, Non-Hodgkin / Q000532:radiotherapy / Q000628:therapy*; D008297:Male; D008875:Middle Aged; D009381:Neoplasms, Radiation-Induced; D010190:Pancreatic Neoplasms / Q000139:chemically induced / Q000209:etiology*; D011241:Prednisone / Q000009:adverse effects; D011878:Radiotherapy / Q000009:adverse effects*; D011879:Radiotherapy Dosage; D013274:Stomach Neoplasms / Q000532:radiotherapy; D014750:Vincristine / Q000009:adverse effects
D000970:Antineoplastic Agents; D014750:Vincristine; D003520:Cyclophosphamide; D002330:Carmustine; D011241:Prednisone