title: Cariostatic activity of calcium glycerophosphate in hamsters: topical vs dietary administration.
abstract: Two experiments were conducted to determine if calcium glycerophosphate administered continuously in a diet or intermittently as a single daily topical application to teeth had an anticaries potential in young hamsters that were fed a cariogenic diet. The hamsters were inoculated with a caries-conductive streptococcal strain. Within the 60-day experimental period, results of these evaluations indicated calcium glycerophosphate significantly reduces caries when fed in the diet at levels of 1% and higher, and significantly reduces caries when applied topically at levels of 2% and higher. There were no observable differences in plaque formation among treatments.
mesh_terms: D000287:Administration, Topical; D000818:Animals; D002130:Calcium Phosphates / Q000008:administration & dosage* / Q000494:pharmacology; D002327:Cariostatic Agents; D006224:Cricetinae; D003731:Dental Caries / Q000517:prevention & control*; D003773:Dental Plaque / Q000517:prevention & control; D004032:Diet; D005994:Glycerophosphates / Q000008:administration & dosage* / Q000494:pharmacology; D008297:Male; D014099:Toothbrushing
chemical_list: D002130:Calcium Phosphates; D002327:Cariostatic Agents; D005994:Glycerophosphates