Interacting populations affecting proliferation of leukemic cells in culture.
Peripheral blood cells from three patients with acute leukemic have been studied using a suspension culture method previously described.1 Cytogenetic studies in two of the patients permitted the identification of the proliferating cells in the cultures as being derived from a leukemic population. Cell separation studies using velocity sedimentation supported the concept that growth of the leukemic cells in culture is dependent on an interaction between two populations of leukemic cells.
D001345:Autoradiography; D002455:Cell Division; D002469:Cell Separation; D002478:Cells, Cultured; D002587:Cesium Isotopes; D002869:Chromosome Aberrations; D002903:Chromosomes, Human, 19-20; D002904:Chromosomes, Human, 21-22 and Y; D002906:Chromosomes, Human, 6-12 and X; D003470:Culture Media; D006801:Humans; D007621:Karyotyping; D037102:Lectins; D015470:Leukemia, Myeloid, Acute / Q000097:blood*; D007958:Leukocyte Count; D007962:Leukocytes / Q000528:radiation effects; D011830:Radiation Effects; D011868:Radioisotopes; D013936:Thymidine / Q000378:metabolism; D014316:Tritium; D014461:Ultracentrifugation
D002587:Cesium Isotopes; D003470:Culture Media; D037102:Lectins; D011868:Radioisotopes; D014316:Tritium; D013936:Thymidine