Malaria complicating neoplastic disease.
Two patients with neoplastic disease had transfusion-induced malaria. In a patient with acute myelogenous leukemia infected with Plasmodium vivax, neither his underlying disease nor intensive cytotoxic chemotherapy appeared to ameliorate or worsen the clinical course of his infection. In a splenectomized patient with metastatic carcinoma of the colon, P malariae infection was associated with a fulminant course simulating cerebral malaria. Despite delay in diagnosis, both patients responded dramatically to antimalarial chemotherapy and both developed appreciable antibody responses.
D000328:Adult; D000906:Antibodies / Q000032:analysis; D000917:Antibody Formation; D002738:Chloroquine / Q000627:therapeutic use; D003110:Colonic Neoplasms / Q000150:complications* / Q000601:surgery; D005260:Female; D006488:Hemostasis, Surgical; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000150:complications* / Q000276:immunology / Q000628:therapy; D008288:Malaria / Q000150:complications* / Q000209:etiology / Q000276:immunology; D008297:Male; D009362:Neoplasm Metastasis; D011183:Postoperative Complications / Q000209:etiology; D065227:Transfusion Reaction
D000906:Antibodies; D002738:Chloroquine