Purkinje cell degeneration, a new neurological mutation in the mouse.
A new autosomal recessive mouse mutation, Purkinje cell degeneration (pcd), is described. Mutants exhibit a moderate ataxia beginning at 3 to 4 weeks of age. The ataxia results from postnatal degeneration of virtually all cerebellar Purkinje cells beginning around 15 to 18 days of age and progressing rapidly over the next 2 weeks. In addition to the cerebellar disease there is slow progressive degeneration in the retina (photoreceptor cells) and olfactory bulb. Also, adult males have abnormal sperm.
D000818:Animals; D001259:Ataxia / Q000209:etiology; D001835:Body Weight; D002531:Cerebellum / Q000473:pathology; D005298:Fertility; D005808:Genes, Recessive; D008297:Male; D051379:Mice; D009154:Mutation; D009410:Nerve Degeneration; D009830:Olfactory Bulb / Q000473:pathology; D011689:Purkinje Cells / Q000473:pathology*; D012160:Retina / Q000473:pathology; D013094:Spermatozoa / Q000473:pathology