[Study of antihypoxic properties and toxicity of mexamine (5-methoxytryptamine)].
On its introduction to mongrel albino mice in doses of 1 to 200 mg/kg mexamine (5-methoxytryptamine) exerted a marked antihypoxic action in conditions of hypoxic hypoxia (a "rise" in the pressure chamber to an altitude of 8000 to 10 000 m) 5--180 minutes after administration of the drug. The possibility of reducing the toxicity of mexamine through preventive introduction of the agent in a dose of 1 mg/kg was established. With such a modification of the toxicity no mitigation of the antihypoxic effectiveness of the basic dose of the agent is observed.
D008735:5-Methoxytryptamine / Q000008:administration & dosage / Q000627:therapeutic use* / Q000633:toxicity; D000284:Administration, Oral; D000531:Altitude; D000818:Animals; D001273:Atmosphere Exposure Chambers; D004305:Dose-Response Relationship, Drug; D000860:Hypoxia / Q000188:drug therapy* / Q000401:mortality; D007274:Injections, Intraperitoneal; D007279:Injections, Subcutaneous; D008297:Male; D051379:Mice; D014363:Tryptamines / Q000627:therapeutic use*
D014363:Tryptamines; D008735:5-Methoxytryptamine
Izuchenie antigipoksicheskikh svoĭstv i toksichnosti meksamina (5-metoksitriptamina).