title: Clinical study of iodine as a chemotherapeutic agent for the control of dental plaque and gingivitis in man.
abstract: The present investigation was conducted to study the effect of the local use of iodine solution as a chemotherapeutic agent on the degree of dental plaque formation and ongingival status in the presence and absence of mechanical oral hygiene. Thirty-six male dental students, 20 freshmen and 16 sophomores, at Case Western Reserve University, participated in the study. All subjects received a prophylaxis and oral hygiene instruction to reduce their plaque and gingival scoeres before the start of the experiment. The 20 freshmen dental students were selected for the test of iodine used in a form of mouthwash. The subjects were randomly divided into two groups. One group received a 0.02% iodine mouthwash, the other a placebo solution of distilled water. Each student was randomly assigned to brush and floss the right or left side of his dentition once daily. The students rinsed with 7.5 ml. of the assigned solution twice daily. The 16 sophomore dental students were selected for the test of iodine applied topically on the tooth surfaces. The subjects were assigned to a randomized block design in which each quadrant received one of the following treatments daily: topical application of iodine solution (2.0% I2 and 2.4% NaI) with brushing and flossing, brushing and flossing only, topical application of iodine solution only, and topical application of distilled water only...
mesh_terms: D000287:Administration, Topical; D000328:Adult; D003773:Dental Plaque / Q000517:prevention & control*; D005891:Gingivitis / Q000517:prevention & control*; D006801:Humans; D007455:Iodine / Q000008:administration & dosage / Q000627:therapeutic use*; D008297:Male; D009067:Mouthwashes; D009910:Oral Hygiene; D010919:Placebos
chemical_list: D009067:Mouthwashes; D010919:Placebos; D007455:Iodine