Effect of chemical sympathectomy (6-hydroxydopamine) on gastrointestinal propulsion after laparotomy. An experimental study in the rat.
The effect of chemical sympathectomy on gastric evacuation and small bowel propulsion 15 hours after a standardized laparotomy was evaluated. The animals were pre-treated with 50 mg/kg i. v. of 6-hydroxydopamine 15 or 48 hours or 150 mg/kg 48 hours before the evaluation of gastrontestinal propulsion. The treatment did not prevent the postoperative retardation. On the contrary 6-hydroxydopamine in itself seemed to retard gastrointestinal propulsion. In simultaneously adrenal demedullated rats no further retardation was produced by the laparotomy.
D000005:Abdomen / Q000601:surgery*; D000313:Adrenal Medulla / Q000502:physiology; D000818:Animals; D001835:Body Weight; D005769:Gastrointestinal Motility / Q000187:drug effects; D006892:Hydroxydopamines / Q000494:pharmacology*; D007421:Intestine, Small / Q000502:physiology; D008297:Male; D051381:Rats; D013270:Stomach / Q000502:physiology; D013564:Sympathetic Nervous System / Q000187:drug effects*
D006892:Hydroxydopamines