title: Familial reactive arthritis of Reiter's and ankylosing spondylitis types in the HLA-27 genotype.
abstract: The close relationship between Reiter's disease and ankylosing spondylitis, which had previously been suspected on the grounds of family and population studies, has been re-emphasised following the recent demonstration of their common close association with the HLA-27 genotype. Nevertheless there are few case reports of both conditions occurring simultaneously in first degree relatives; and documentation of HLA genotype in such families was not generally considered before 1973. Both varieties of reactive arthritis are reported here as occurring in first degree relatives sharing HLA-27 genotype.
mesh_terms: D000328:Adult; D016918:Arthritis, Reactive / Q000235:genetics* / Q000276:immunology; D005260:Female; D005838:Genotype; D006680:HLA Antigens; D006649:Histocompatibility Antigens; D006801:Humans; D008297:Male; D008875:Middle Aged; D013167:Spondylitis, Ankylosing / Q000235:genetics* / Q000276:immunology
chemical_list: D006680:HLA Antigens; D006649:Histocompatibility Antigens