[New chromosome abnormality in chronic myeloid leukemia].
A case of chronic myelogenous leukemia with myelofibrosis and failure to respond to busulfan therapy has been reported. An abnormal clone with a rearrangement of four chromosomes, 46, XX, t(1;9) (q21; q24), t(6;22) (q26;q11) was observed. The possible significance of these chromosome abnormalities which are different from the t(9;22) translocation in C.M.L. is discussed.
D001853:Bone Marrow / Q000473:pathology; D001854:Bone Marrow Cells; D002066:Busulfan / Q000627:therapeutic use; D002869:Chromosome Aberrations; D002872:Chromosome Deletion; D002900:Chromosomes, Human, 1-3; D002904:Chromosomes, Human, 21-22 and Y; D002906:Chromosomes, Human, 6-12 and X; D002999:Clone Cells; D005260:Female; D006801:Humans; D007621:Karyotyping; D037102:Lectins / Q000494:pharmacology; D007951:Leukemia, Myeloid / Q000188:drug therapy / Q000235:genetics*; D008214:Lymphocytes; D008875:Middle Aged; D055728:Primary Myelofibrosis; D014178:Translocation, Genetic
D037102:Lectins; D002066:Busulfan
Anomalie chromosomique nouvelle dans une leucémia myéloïde chronique