Monosomy 7 in two adult patients with acute myeloblastic leukaemia.
Two patients with acute myeloblastic leujaemia were found to have a population of bone marrow cells with C-group monosomy. Using the Quinacrine Mustard fluorescence technique the lacking chromosome was in both patients identified as a number 7. Both patients entered a complete remission. Monosomy 7 may indicate a separate entity of acute myeloblastic leukaemia associated with a comparatively favourable prognosis.
D000782:Aneuploidy; D001853:Bone Marrow / Q000648:ultrastructure*; D001854:Bone Marrow Cells; D002906:Chromosomes, Human, 6-12 and X; D005260:Female; D006801:Humans; D007621:Karyotyping; D015470:Leukemia, Myeloid, Acute / Q000097:blood / Q000235:genetics*; D008875:Middle Aged; D008938:Mitosis; D011797:Quinacrine Mustard
D011797:Quinacrine Mustard