title: Induction of malignant bone tumors in rats by 1-(2-hydroxyethyl)-1-nitrosourea.
abstract: Forty male MRC-W rats were treated chronically with 1-(2-hydroxyethyl)-1-nitrosourea in drinking water (total dose, 330 mg/rat). Fifteen rats (38%) developed osteogenic osteosarcomas or chondrosarcomas of the lower vertebrae. This was the first time that an orally administered organic compound induced a high incidence of these tumors.
mesh_terms: D000284:Administration, Oral; D000818:Animals; D002813:Chondrosarcoma / Q000139:chemically induced*; D008297:Male; D009607:Nitrosourea Compounds / Q000008:administration & dosage; D012516:Osteosarcoma / Q000139:chemically induced*; D051381:Rats; D013125:Spinal Neoplasms / Q000139:chemically induced*
chemical_list: D009607:Nitrosourea Compounds