title: Preparation of a new immunosuppressant, 4-5-bis(aminomethyl)acridine.
abstract: 4,5-Bis(aminomethyl)acridine, useful as an immunosuppressant, was prepared in 31% overall yield by the reaction of acridine with N-(hydroxymethyl)phthalimide and subsequent decomposition with excess 6 N HCl. The drug was found to produce a suppression of the humoral antibody response comparable to several known immunosuppressive agents.
mesh_terms: D000166:Acridines / Q000138:chemical synthesis* / Q000494:pharmacology; D000818:Animals; D000917:Antibody Formation / Q000187:drug effects; D000921:Antibody-Producing Cells / Q000187:drug effects; D006462:Hemolytic Plaque Technique; D007166:Immunosuppressive Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D008744:Methylamines / Q000138:chemical synthesis / Q000494:pharmacology; D051379:Mice; D013154:Spleen / Q000276:immunology
chemical_list: D000166:Acridines; D007166:Immunosuppressive Agents; D008744:Methylamines