title: The effects of unsubstituted polycyclic aromatic hydrocarbons on the growth of Escherichia coli.
abstract: The effect on growth of E. coli of a series of 3-, 4-, and 5-ring unsubstituted polycyclic aromatic hydrocarbons (PAH) is determined at concentrations of 10-5M, 10-6M, and 10-7M. The angular hydrocarbon configurations of 1,2-benzanthracene, 1,2,5,6-dibenzanthracene (DIBA), and 3,4-benzpyrene (BP) promote growth; tetracene and pyrene have little or no effect on growth while at most concentrations anthracene, phenanthrene chrysene, 1,2,3,4-dibenzanthracene, and pentacene inhibit bacterial growth. No universal pattern of concentration effect is manifest, but based on the results an angular acene configuration is a necessary condition for growth stimulation.
mesh_terms: D001551:Benz(a)Anthracenes / Q000494:pharmacology; D001580:Benzopyrenes / Q000494:pharmacology; D002455:Cell Division / Q000187:drug effects; D004926:Escherichia coli / Q000187:drug effects / Q000378:metabolism*; D006838:Hydrocarbons / Q000494:pharmacology*; D010616:Phenanthrenes / Q000494:pharmacology; D011721:Pyrenes / Q000494:pharmacology; D013329:Structure-Activity Relationship
chemical_list: D001551:Benz(a)Anthracenes; D001580:Benzopyrenes; D006838:Hydrocarbons; D010616:Phenanthrenes; D011721:Pyrenes