Platomycins A and B I Taxonomy of the producing strain and production, isolation and biological properties of platomycins.
Two new antibiotics, platomycins A and B, belonging to the phleomycin-bleomycin family, were isolated from the culture filtrate of Streptosporangium sp. MK-78. This strain has been identified as a new variety of Streptosporangium violaceochromogenes. Both platomycins A and B are active against a variety of Gram-positive and Gram-negative bacteria, and also inhibit solid Sarcoma 180 and Ehrlich ascites carcinoma.
D000192:Actinomycetales / Q000145:classification / Q000378:metabolism*; D000818:Animals; D000900:Anti-Bacterial Agents / Q000302:isolation & purification* / Q000494:pharmacology; D000903:Antibiotics, Antineoplastic / Q000627:therapeutic use; D001407:Bacillus / Q000187:drug effects; D002286:Carcinoma, Ehrlich Tumor / Q000188:drug therapy; D003470:Culture Media; D004926:Escherichia coli / Q000187:drug effects; D007928:Lethal Dose 50; D051379:Mice; D008826:Microbial Sensitivity Tests; D012510:Sarcoma 180 / Q000188:drug therapy; D013291:Streptococcus / Q000187:drug effects
D000900:Anti-Bacterial Agents; D000903:Antibiotics, Antineoplastic; D003470:Culture Media