title: Adrenocortical function related to Althesin anaesthesia and surgery in man.
abstract: Althesin anaesthesia alone had no significant effect on plasma cortisol concentration. When Althesin induction was followed by maintenance with N2O and halothane there was a statistically insignificant fall, but with N2O, pancuronium and I.P.P.V there was a tendency for plasma cortisol concentrations to rise. This, too, was statistically not significant. A significant elevation in the mean plasma cortisol concentration was only found in patients during abdominal surgery.
mesh_terms: D000005:Abdomen / Q000601:surgery; D000293:Adolescent; D000302:Adrenal Cortex / Q000187:drug effects*; D000311:Adrenal Glands / Q000187:drug effects*; D000328:Adult; D000368:Aged; D000530:Alfaxalone Alfadolone Mixture / Q000494:pharmacology*; D000771:Anesthesia, Intravenous; D002986:Clinical Trials as Topic; D005260:Female; D006221:Halothane / Q000494:pharmacology; D006801:Humans; D006854:Hydrocortisone / Q000097:blood; D008875:Middle Aged; D013511:Minor Surgical Procedures; D009609:Nitrous Oxide / Q000494:pharmacology; D010197:Pancuronium / Q000494:pharmacology; D011175:Positive-Pressure Respiration; D011277:Pregnanediones / Q000494:pharmacology*; D013312:Stress, Physiological; D013514:Surgical Procedures, Operative
chemical_list: D011277:Pregnanediones; D000530:Alfaxalone Alfadolone Mixture; D010197:Pancuronium; D009609:Nitrous Oxide; D006221:Halothane; D006854:Hydrocortisone