The effect of anti-immunoglobulin antibodies of Fc rosettes.
This study demonstrated that Fc rosettes detected by antibody-labeled bovine erythrocytes can be inhibited by immune complexes of rabbit IgG (b4 allotype) and anti-b4 IgG, thus showing that these complexes effectively compete for the receptor for erythrocyte-antibody rosettes. Incubation of mouse lymphocytes with goat F(ab')2 anti-mouse IgG did not inhibit Fc rosettes. When immunoglobulin on murine and human B lymphocytes was redistributed in a polar cap on the membrane by interaction with anti-immunoglobulin antibodies, the number of Fc rosettes after 'capping' was unchanged; most of the indicator erythrocytes, however, were distributed in a cap as well. This erythrocyte cap was superimposed on the immunoglobulin cap.
D000818:Animals; D000888:Antibodies, Anti-Idiotypic; D000936:Antigen-Antibody Complex; D004912:Erythrocytes / Q000276:immunology*; D007104:Immune Adherence Reaction; D007114:Immunization; D007140:Immunoglobulin Fab Fragments; D007141:Immunoglobulin Fc Fragments; D007074:Immunoglobulin G; D008214:Lymphocytes / Q000276:immunology*; D051379:Mice; D008806:Mice, Inbred AKR; D008808:Mice, Inbred CBA; D013696:Temperature
D000888:Antibodies, Anti-Idiotypic; D000936:Antigen-Antibody Complex; D007140:Immunoglobulin Fab Fragments; D007141:Immunoglobulin Fc Fragments; D007074:Immunoglobulin G