Intraepithelial vaginal neoplasia following immunosuppressive therapy treated with topical 5-Fu.
A case is reported of the successful treatment of multifocal intraepithelial neoplasia of the vagina by topical application of a cytotoxic agent, 5-fluorouracil. These lesions followed prolonged immunosuppressive therapy after renal transplantation. Intraepithelial neoplasia was present also in the cervix and was treated by conization.
D000287:Administration, Topical; D000328:Adult; D001379:Azathioprine / Q000009:adverse effects / Q000627:therapeutic use; D001706:Biopsy; D002294:Carcinoma, Squamous Cell / Q000188:drug therapy* / Q000209:etiology; D002584:Cervix Uteri / Q000473:pathology; D005260:Female; D005472:Fluorouracil / Q000008:administration & dosage / Q000627:therapeutic use*; D006801:Humans; D007166:Immunosuppressive Agents / Q000009:adverse effects*; D016030:Kidney Transplantation; D009378:Neoplasms, Multiple Primary / Q000188:drug therapy* / Q000209:etiology; D011247:Pregnancy; D014184:Transplantation, Homologous; D014621:Vagina / Q000473:pathology; D014625:Vaginal Neoplasms / Q000188:drug therapy* / Q000209:etiology
D007166:Immunosuppressive Agents; D001379:Azathioprine; D005472:Fluorouracil