Sex-determined antigens in rats detected by bone marrow transplantation but not skin grafting.
Skin grafting in untreated rats and bone marrow transplantation into minimally immunosuppressed recipients have been used to investigate histocompatibility differences associated with the Y chromosome. Male skin survived for upwards of 120 days with no sign of rejection when grafted into female rats in circumstances where male bone marrow was rejected. Y chromosome-associated antigens were only detected with skin grafting by prior exposure of the female rats to male cells. It is concluded that bone marrow grafting into minimally immunosuppressed recipients may provide a more sensitive index of minor histocompatibility differences than skin grafting. The need to recognise donor cells in recipients prepared for bone marrow grafting with cytotoxic chemicals is emphasized.
D000818:Animals; D001854:Bone Marrow Cells; D016026:Bone Marrow Transplantation; D002066:Busulfan / Q000494:pharmacology; D005260:Female; D006084:Graft Rejection; D006649:Histocompatibility Antigens / Q000032:analysis*; D007115:Immunization Schedule; D007165:Immunosuppression Therapy; D007621:Karyotyping; D007928:Lethal Dose 50; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D012730:Sex Chromosomes; D012737:Sex Factors; D016038:Skin Transplantation; D014184:Transplantation, Homologous
D006649:Histocompatibility Antigens; D002066:Busulfan