New azasteroidal antifungal antibotics from Geotrichum flavo-brunneum. I. Discovery and fermentation studies.
Although Geotrichum species occur ubiquitously, antibiotic production by members of this genus has not previously been reported. The antibiotic complex designated A25822, consisting of one major and six minor structurally-related components active primarily against Candida and Trichophyton, represents a new family of naturally-occurring compounds. Approximately 90% of the antibiotic activity synthesized remained associated with the fungal cell mass, from which it was recovered by multiple methanolic extractions for quantitation. Antibiotic production was enhanced by tryptophan, iron, zinc, and high levels of dextrin.
D000935:Antifungal Agents / Q000302:isolation & purification* / Q000494:pharmacology; D001372:Aza Compounds / Q000302:isolation & purification / Q000494:pharmacology; D002176:Candida albicans / Q000187:drug effects; D002241:Carbohydrates / Q000494:pharmacology; D002774:Cholestadienes / Q000302:isolation & purification* / Q000494:pharmacology; D005285:Fermentation; D006718:Homosteroids / Q000302:isolation & purification / Q000494:pharmacology; D007501:Iron / Q000494:pharmacology; D003904:Mitosporic Fungi / Q000032:analysis* / Q000378:metabolism; D013696:Temperature; D014249:Trichophyton / Q000187:drug effects; D014364:Tryptophan / Q000494:pharmacology; D015032:Zinc / Q000494:pharmacology
D000935:Antifungal Agents; D001372:Aza Compounds; D002241:Carbohydrates; D002774:Cholestadienes; D006718:Homosteroids; D014364:Tryptophan; D007501:Iron; D015032:Zinc