[Assessment of the somatotropic function of the hypophysis in patients with hypophyseal nanism and gonadal dysgenesis by using the insulin-tolerance and arginine-tolerance tests].
With the aid of insulin-tolerance and arginine tolerance tests (ITT and ATT, respectively) somatotropic function of the hypophysis was assessed in 18 patients with hypophyseal nanism and in 12--with gonad dysgenesis.  A marked delay in development and a premature exhaustion of the STH secretion was noted in the patients wiht hypophyseal nanism.  In patients with gonad dysgenesis the STH secretion was somewhat redeced during the ITT.  A change in the STH secretion was accompanied by a parallel depression of insulin secretion during the ATT.  Patients with hypophyseal nanism displayed a correlation between the extent of growth delay and the value of the STH secretion during the ITT (R=0.6, P smaller than 0.05).
D000293:Adolescent; D000328:Adult; D001120:Arginine; D001786:Blood Glucose / Q000378:metabolism; D001827:Body Height; D004393:Dwarfism, Pituitary / Q000503:physiopathology*; D005260:Female; D013006:Growth Hormone / Q000378:metabolism*; D006801:Humans; D007328:Insulin / Q000378:metabolism; D000078790:Insulin Secretion; D007515:Islets of Langerhans / Q000503:physiopathology; D010902:Pituitary Gland / Q000503:physiopathology*; D013997:Time Factors; D014424:Turner Syndrome / Q000503:physiopathology*
D001786:Blood Glucose; D007328:Insulin; D013006:Growth Hormone; D001120:Arginine
Otsenka somatotropnoĭ funktsii gipofiza u bol'nykh s gipofizarnym nanizmom i disgenezieĭ gonad pri pomoshchi insulin-tolerantnogo i arginin-tolerantnogo testov