Action of morphine sulfphate on stimulated gastric secretion in dogs.
In dogs morphine sulphate suppresses both 2-deoxy-D-glucose and pentagastrin-stimulated acid and pepsin secretion, but not histimaine- and pilocarpine-stimulated acid. This is consistent with the view that morphine both depresses acetylcholine release from cholinergic endings in the stomach and that pentagastrin acts by liberation of acetylcholine from these endings.
D000109:Acetylcholine / Q000378:metabolism; D000818:Animals; D003847:Deoxyglucose / Q000494:pharmacology; D003864:Depression, Chemical; D004285:Dogs; D005402:Fistula; D005750:Gastric Juice / Q000378:metabolism*; D006632:Histamine / Q000008:administration & dosage / Q000494:pharmacology; D007981:Levorphanol / Q000494:pharmacology; D009020:Morphine / Q000494:pharmacology*; D009269:Nalorphine / Q000494:pharmacology; D010418:Pentagastrin / Q000008:administration & dosage / Q000494:pharmacology; D010434:Pepsin A / Q000378:metabolism; D010862:Pilocarpine / Q000008:administration & dosage / Q000494:pharmacology; D013268:Stimulation, Chemical; D013270:Stomach / Q000187:drug effects* / Q000502:physiology / Q000601:surgery
D010862:Pilocarpine; D007981:Levorphanol; D009020:Morphine; D006632:Histamine; D003847:Deoxyglucose; D010434:Pepsin A; D010418:Pentagastrin; D000109:Acetylcholine; D009269:Nalorphine