Spontaneous redistribution of surface immunoglobulin in the motile B lymphocyte.
This paper reports that B cells undergoing translatory motion spontaneously segregate their surface Ig to one portion of their plasma membrane. The spontaneous redistribution of surface Ig was found to be: (a) selective, concanavalin A-dependent on translatory motion and energy metabolism. Abundant B cells undergoing motility were found after cultures in lipopolysaccharide or trypsin, or after brief exposure to cholinergic drugs.
D000818:Animals; D001402:B-Lymphocytes / Q000276:immunology* / Q000502:physiology / Q000648:ultrastructure; D002217:Carbachol / Q000494:pharmacology; D002465:Cell Movement / Q000187:drug effects; D003078:Colchicine / Q000494:pharmacology; D003593:Cytoplasm / Q000378:metabolism; D006649:Histocompatibility Antigens; D008070:Lipopolysaccharides / Q000494:pharmacology; D008213:Lymphocyte Activation; D008565:Membrane Proteins / Q000378:metabolism*; D051379:Mice; D011947:Receptors, Antigen, B-Cell / Q000378:metabolism*; D011952:Receptors, Concanavalin A / Q000378:metabolism; D014357:Trypsin
D006649:Histocompatibility Antigens; D008070:Lipopolysaccharides; D008565:Membrane Proteins; D011947:Receptors, Antigen, B-Cell; D011952:Receptors, Concanavalin A; D002217:Carbachol; D014357:Trypsin; D003078:Colchicine