The therapeutic application of end-expiratory pressure in the meconium aspiration syndrome.
The effectiveness of end-expiratory pressure (EEP) in relieving hypoxemia in the meconium aspiration syndrome (MAS) was studied in 14 patients with the disorder. These infants demonstrated a direct, mean PO2 response of 12 torr/cm H2O EEP. A maximum PO2 response was observed in an EEP range of 4 to 7 cm H2O. EEP was equally effective whether patients were breathing spontaneously or were being mechanically ventilated. EEP is useful in the treatment of hypoxemia in the infants with meconium aspiration syndrome.
D001784:Blood Gas Analysis; D006801:Humans; D007231:Infant, Newborn; D007232:Infant, Newborn, Diseases / Q000503:physiopathology / Q000628:therapy*; D001239:Inhalation; D007442:Intubation, Intratracheal; D008470:Meconium / Q000503:physiopathology*; D011175:Positive-Pressure Respiration; D012119:Respiration; D012127:Respiratory Distress Syndrome, Newborn / Q000209:etiology; D013577:Syndrome