Ontogeny of the antibody-forming cell line in mice. I. Kinetics of appearance of mature B cells.
The development of functionally mature B cells in the liver and spleen of fetal and neonatal CBA mice has been followed. A mature B cell is defined as one giving rise to antibody-producing progeny within 2 days in culture. Very few such B cells are found during fetal life. After birth there is a rapid rise in the numbers reaching 1/3 of adult levels in the 7-day-old spleen.
D000367:Age Factors; D000818:Animals; D000831:Animals, Newborn; D000921:Antibody-Producing Cells / Q000166:cytology*; D001402:B-Lymphocytes / Q000166:cytology / Q000276:immunology*; D002454:Cell Differentiation; D002478:Cells, Cultured; D004912:Erythrocytes / Q000276:immunology; D005260:Female; D008099:Liver / Q000196:embryology / Q000276:immunology; D008297:Male; D051379:Mice; D008808:Mice, Inbred CBA; D013154:Spleen / Q000196:embryology / Q000276:immunology; D013997:Time Factors