title: Cell interactions between histoincompatible T and B lymphocytes. VIII. In vivo cooperative responses between lymphocytes are controlled by genes in the K-end of the H-2 complex.
abstract: The genetic restrictions for successful carrier-primed T cell and hapten-primed B cell cooperative interactions were established in a totally in vivo double adoptive transfer system. In complementation experiments, we have demonstrated that genes localized in the K-end of the H-2 complex control successful T-B cell cooperative interactions. Thus, DBA/2 KLH-primed T cells cooperated with (C3H times C3H.OH)F1 and (C3H times C3H.OL)F1 DNP-primed B cells to make a secondary response to DNP-KLH, but not with (C3H times C3H.A)F1 DNP-PRImed cells. The presence of foreign histocompatibility determinants on the F1 B cells did not prevent successful physiologic cell cooperation provided the T and B cells shared common cell interaction genes coded for in the K-end of the H-2 complex.
mesh_terms: D000614:Aminocaproates / Q000378:metabolism; D000818:Animals; D000906:Antibodies / Q000032:analysis; D000961:Antilymphocyte Serum; D001200:Ascaris; D001402:B-Lymphocytes / Q000276:immunology*; D002874:Chromosome Mapping; D004140:Dinitrophenols / Q000276:immunology; D006433:Hemocyanins; D006648:Histocompatibility; D006649:Histocompatibility Antigens; D007116:Immunization, Passive; D007117:Immunization, Secondary; D007156:Immunologic Memory; D051379:Mice; D008811:Mice, Inbred DBA; D011828:Radiation Chimera; D013154:Spleen / Q000166:cytology; D013601:T-Lymphocytes / Q000276:immunology*; D014020:Tissue Extracts; D014316:Tritium
chemical_list: D000614:Aminocaproates; D000906:Antibodies; D000961:Antilymphocyte Serum; D004140:Dinitrophenols; D006649:Histocompatibility Antigens; D014020:Tissue Extracts; D014316:Tritium; D006433:Hemocyanins