title: [Use of ftorafur for the treatment of 3d-4th stage].
abstract: To treat ovarian cancer of stage III-IV the authors have used an antimetabolite-fluorafur. A total dosage of 17-23 g. "marked improvement" was noted in 15 patients, "insignificant improvement" - in 9, there was no improvement in one case. It was found that the level of FSH excretion was reduced twice under the influence of fluorafur, the greater decrease corresponding to a better clinical effect. The drug used in doses applied by the authors, proved to be nontoxic.
mesh_terms: D000230:Adenocarcinoma / Q000188:drug therapy; D000328:Adult; D000368:Aged; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D002986:Clinical Trials as Topic; D004341:Drug Evaluation; D005260:Female; D005472:Fluorouracil / Q000031:analogs & derivatives* / Q000627:therapeutic use; D005640:Follicle Stimulating Hormone / Q000652:urine; D005663:Furans / Q000627:therapeutic use; D006801:Humans; D007275:Injections, Intravenous; D008875:Middle Aged; D010051:Ovarian Neoplasms / Q000188:drug therapy*
chemical_list: D000970:Antineoplastic Agents; D005663:Furans; D005640:Follicle Stimulating Hormone; D005472:Fluorouracil
vernacular_title: Primenenie ftorafura dlia lecheniia raka iaichnikov III-IV stadiĭ