Ag-F: serological and genetic identification of a new locus in the rat governing lymphocyte membrane antigens.
A new genetic locus in the rat (Ag-F) is described. It controls expression of lymphocyte membrane antigens as determined by allospecific cytotoxic antibody. It is linked by approximately two recombination units to the gene for albinism and is therefore in linkage group I. It is suggested that Ag-F is the homologue in the rat of mouse H-1. It appears to be highly polymorphic and yields antigens which are highly cross reactive serologically. Disparity at Af-F is the probable cause of alloantibody responses attributable to reciprocal immunization between the Lewis and Fischer strains.
D000042:Absorption; D000818:Animals; D000917:Antibody Formation; D000918:Antibody Specificity; D002462:Cell Membrane / Q000276:immunology*; D003429:Cross Reactions; D003601:Cytotoxicity Tests, Immunologic; D005260:Female; D008040:Genetic Linkage; D006649:Histocompatibility Antigens / Q000302:isolation & purification*; D006801:Humans; D007106:Immune Sera; D008198:Lymph Nodes / Q000166:cytology; D008214:Lymphocytes / Q000276:immunology*; D008297:Male; D011110:Polymorphism, Genetic; D051381:Rats; D011914:Rats, Inbred BN; D011916:Rats, Inbred F344; D011917:Rats, Inbred Lew; D011919:Rats, Inbred Strains; D011995:Recombination, Genetic
D006649:Histocompatibility Antigens; D007106:Immune Sera