Correlation between anti-DNA antibody titre and psychiatric manifestations in systemic lupus erythematosus.
A patient with systemic lupus erythematosus with predominant psychiatric involvement was followed during two psychotic exacerbations of her disease. A high correlation was found between disease activity and the titre of anti-DNA antibodies. Disease activity was preceded and accompanied by a high titre, while remission was associated with low titre. The significance of this correlation for the pathogenesis, diagnosis and managment of the psychiatric symptoms of systemic lupus erythematosus are discussed.
D000328:Adult; D000974:Antibodies, Antinuclear / Q000032:analysis*; D003165:Complement System Proteins / Q000032:analysis; D004247:DNA / Q000276:immunology*; D005260:Female; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000150:complications / Q000276:immunology*; D011618:Psychotic Disorders / Q000209:etiology* / Q000276:immunology
D000974:Antibodies, Antinuclear; D003165:Complement System Proteins; D004247:DNA