Studies on the role of the host immune response in recovery from Friend virus leukemia. II. Cell-mediated immunity.
Congenic mouse strains differing only at genes within the H-2 complex were found to have virus-specific cytotoxic effector cells in their spleens during or after recovery from Friend leukemia virus-induced splenomegaly. These effector cells were theta-positive T lymphocytes which functioned in vitro without help or inhibition by B lymphocytes or glass-adherent cells. The antigenic specificities recognized by the effector cells were viral-induced cellular antigens apparently different from those identified by serological techniques.
D000818:Animals; D000951:Antigens, Neoplasm; D000956:Antigens, Viral; D002460:Cell Line; D003601:Cytotoxicity Tests, Immunologic; D005622:Friend murine leukemia virus / Q000276:immunology*; D005796:Genes; D005838:Genotype; D007106:Immune Sera; D007111:Immunity, Cellular; D007942:Leukemia, Experimental / Q000276:immunology*; D008223:Lymphoma / Q000276:immunology; D051379:Mice; D008807:Mice, Inbred BALB C; D008810:Mice, Inbred C57BL; D008815:Mice, Inbred Strains; D008979:Moloney murine leukemia virus; D013154:Spleen / Q000276:immunology*; D013601:T-Lymphocytes / Q000276:immunology
D000951:Antigens, Neoplasm; D000956:Antigens, Viral; D007106:Immune Sera