Studies on the mechanism of somatostatin action on insulin release in man. I. Effect of blockade of alpha-adrenergic receptors.
The present studies have demonstrated that the growth hormone releaseinhibiting factor of the hypothalamus, somatostatin, exerts a prominent inhibiting action on glucose induced insulin release in man. This inhibition of insulin release could not be reversed by infusion of the alpha-adrenergic blocking agent, phentolamine. Our findings therefore suggest that the inhibiting effect of somatostatin on glucose induced insulin release is not mediated by the alpha-adrenergic receptors.
D000328:Adult; D001786:Blood Glucose; D003864:Depression, Chemical; D004305:Dose-Response Relationship, Drug; D005260:Female; D005947:Glucose / Q000494:pharmacology*; D013007:Growth Hormone-Releasing Hormone / Q000037:antagonists & inhibitors*; D006801:Humans; D007328:Insulin / Q000097:blood / Q000378:metabolism*; D000078790:Insulin Secretion; D008297:Male; D010455:Peptides / Q000494:pharmacology*; D010646:Phentolamine / Q000494:pharmacology*; D011863:Radioimmunoassay; D011941:Receptors, Adrenergic; D013268:Stimulation, Chemical
D001786:Blood Glucose; D007328:Insulin; D010455:Peptides; D011941:Receptors, Adrenergic; D013007:Growth Hormone-Releasing Hormone; D005947:Glucose; D010646:Phentolamine