Failure of angiotensin II inhibitor to modify hyperacute rejection.
The effect of angiotensin II inhibitor (sar1,gly8 angiotensin II) upon the pig-to-dog (10 pigs to 20 dogs) modified renal xenograft model has been studied. The angiotensin II inhibitor does not prevent hyperacute rejection (HAR). This implies that the vasocaonstriction which occurs during the HAR is not related to high levels of angiotensin II.
D000804:Angiotensin II / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000037:antagonists & inhibitors / Q000494:pharmacology; D000818:Animals; D001706:Biopsy; D001772:Blood Cell Count; D004285:Dogs; D005998:Glycine; D006084:Graft Rejection; D006400:Hematocrit; D007263:Infusions, Parenteral; D007668:Kidney / Q000473:pathology; D016030:Kidney Transplantation; D010477:Perfusion; D012039:Regional Blood Flow / Q000187:drug effects; D012082:Renal Veins; D012083:Renin / Q000097:blood; D012521:Sarcosine; D012965:Sodium Chloride; D013552:Swine; D014183:Transplantation, Heterologous; D014556:Urine / Q000187:drug effects
D000804:Angiotensin II; D012965:Sodium Chloride; D012083:Renin; D005998:Glycine; D012521:Sarcosine