[Study of several parameters of hemostasis in Masugi's rabbit nephritis].
During experimental Masugi nephritis in the rabbit, were demonstrated various disturbances in hemostasis: a) during the initial stage: immediate, severe and transient fall in the platelet count without any change in Factor V;b)during the secondary stage, from the 7th to the 8th day onwards, increase in platelets and fibrinogen, in relation with the intensity of the nephrotic syndrome; c) in parallel, appearance of urinary fibrinogen split products in relation to the intensity of the glomerular lesions, evidence for the presence of intraglomerular fibrin. These facts confirm the role played by platelets in coagulation phenomena secondary to the immune reaction. They indicate, furthermore, the existence of hemostasis disorders during the nephrotic syndrome.
D000818:Animals; D000941:Antigens / Q000032:analysis; D001772:Blood Cell Count; D001777:Blood Coagulation; D001792:Blood Platelets; D003165:Complement System Proteins / Q000032:analysis; D004372:Ducks / Q000276:immunology; D005165:Factor V / Q000032:analysis; D005337:Fibrin / Q000276:immunology; D005340:Fibrinogen / Q000032:analysis / Q000276:immunology; D005921:Glomerulonephritis / Q000097:blood* / Q000473:pathology; D006400:Hematocrit; D007106:Immune Sera; D007678:Kidney Glomerulus / Q000276:immunology / Q000473:pathology; D009404:Nephrotic Syndrome / Q000209:etiology; D010974:Platelet Aggregation; D011507:Proteinuria / Q000209:etiology; D011817:Rabbits / Q000276:immunology
D000941:Antigens; D007106:Immune Sera; D005165:Factor V; D005337:Fibrin; D005340:Fibrinogen; D003165:Complement System Proteins
Etude de quelques paramètres de l'hémostase dans la néphrite de Masugi du lapin