title: Quantitative relationship between carcinogenicity and mutagenicity of polyaromatic hydrocarbons in Salmonella typhimurium mutants.
abstract: Mutagenic activities of various polyaromatic hydrocarbons (PAHs) in air pollutants, which are different in carcinogenic activities from each other, were examined with a set of four strains of Salmonella typhimurium (TAI535 series; deep rough strains without excision repair). All the compounds tested were converted to frameshift mutagens when they were metabolized by rat liver homogenate. There was a clear quantitative correlation between carcinogenicity and mutagenicity of PAHs tested in strain TAI538 using the rat liver enzyme induced with both dibenz(a,h)-anthracene and phenobarbital. On the other hand, such a correlation was not obvious in strain TAI537.
mesh_terms: D000393:Air Pollutants; D000818:Animals; D001551:Benz(a)Anthracenes / Q000494:pharmacology; D001580:Benzopyrenes / Q000494:pharmacology; D002273:Carcinogens / Q000494:pharmacology*; D002470:Cell Survival; D004121:Dimethyl Sulfoxide / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D004790:Enzyme Induction; D005815:Genetic Code; D006838:Hydrocarbons / Q000494:pharmacology*; D008099:Liver / Q000201:enzymology; D008110:Liver Extracts; D008297:Male; D008748:Methylcholanthrene / Q000494:pharmacology; D009153:Mutagens / Q000494:pharmacology*; D009154:Mutation; D010634:Phenobarbital / Q000494:pharmacology; D051381:Rats; D012486:Salmonella typhimurium / Q000187:drug effects*; D014158:Transcription, Genetic
chemical_list: D000393:Air Pollutants; D001551:Benz(a)Anthracenes; D001580:Benzopyrenes; D002273:Carcinogens; D006838:Hydrocarbons; D008110:Liver Extracts; D009153:Mutagens; D008748:Methylcholanthrene; D004121:Dimethyl Sulfoxide; D010634:Phenobarbital