[Permeability of the mitochondrial membranes of the organs of white rats innoculated with Walker carcinoma to lipoic acid and thiamine labelled with S35].
Mitochondria isolated from organs of intact white rats and those with Walker carcinoma were incubated in Gubler medium containing S35-lipoic acid or S35-thiamine. An accumulation of lipoic acid by mitochondria is higher in tumor-bearing animals, while that of thiamine in most organs is lowered. In healthy animals mitochondria were found to accumulate S35-thiamine more intensively than S35-lipoic acid. In tumor animals these indices become nearly similar, while organ differences are leveled.
D000818:Animals; D001921:Brain / Q000378:metabolism; D002279:Carcinoma 256, Walker / Q000378:metabolism*; D005260:Female; D007421:Intestine, Small / Q000378:metabolism; D007668:Kidney / Q000378:metabolism; D008099:Liver / Q000378:metabolism; D008928:Mitochondria / Q000378:metabolism*; D008931:Mitochondria, Muscle / Q000378:metabolism; D009132:Muscles / Q000378:metabolism; D010539:Permeability; D051381:Rats; D013462:Sulfur Radioisotopes; D013831:Thiamine / Q000378:metabolism*; D008063:Thioctic Acid / Q000378:metabolism*
D013462:Sulfur Radioisotopes; D008063:Thioctic Acid; D013831:Thiamine
Pronitsaemost' membran mitokhondriĭ iz organov belykh krys s privitoĭ kartsinomoĭ Vokera k lipoevoĭ kislote i tiaminu mechennym po S35