title: [Studies on the influence of pentosanepolysulfate and a combination of pentosanepolysulfate, metamizol and paracetamol on inflammatory liability (author's transl)].
abstract: The influence of pentosanepolysulfate (SP 54) and a combination of pentosanepolysulfate, metamizol and paracetamol (Probaphen) on the course of an experimentally induced erythema caused by intracutaneous injection of a lipopolysaccharide from Pseudomonas has been studied in man. The intramuscular injection of Probaphen as well as SP 54, separately given, showed a significant antiinflammatory effect. A similar effect was also achieved after administration of Probaphen suppositories. Probaphen shortened the inflammatory reaction more effectively than did SP 54 alone. The oral application of Probaphen, however, did not influence the course of inflammation.
mesh_terms: D000082:Acetaminophen / Q000627:therapeutic use*; D000328:Adult; D000632:Aminopyrine / Q000031:analogs & derivatives*; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use*; D002986:Clinical Trials as Topic; D004177:Dipyrone / Q000627:therapeutic use*; D004305:Dose-Response Relationship, Drug; D004338:Drug Combinations; D004890:Erythema / Q000139:chemically induced / Q000188:drug therapy; D006801:Humans; D008070:Lipopolysaccharides; D010426:Pentosan Sulfuric Polyester / Q000627:therapeutic use*; D011134:Polysaccharides / Q000627:therapeutic use*; D013997:Time Factors
chemical_list: D000893:Anti-Inflammatory Agents; D004338:Drug Combinations; D008070:Lipopolysaccharides; D011134:Polysaccharides; D000632:Aminopyrine; D000082:Acetaminophen; D010426:Pentosan Sulfuric Polyester; D004177:Dipyrone
vernacular_title: Untersuchungen zur Beeinflussung der Entzündungsbereitschaft durch Pentosanpolysulfat und einer Kombination aus Pentosanpolysulfat, Metamizol und Paracetamol