Tone audiometry control of children treated for meningitis with large intravenous doses of ampicillin.
Thirty-seven children treated for bacterial meningitis with ampicillin in high doses were followed up with audiometric control. Defects were recorded in 6 cases. Two of these were ascribed to chronic otosalpingitis. In 4 patients with sensorineural hearing loss, 3 were unilateral, and in only one case was the damage bilateral. Even here there was a previous history of hearing loss. A suggested ototoxicity of ampicillin could not be confirmed.
D000667:Ampicillin / Q000008:administration & dosage / Q000009:adverse effects* / Q000627:therapeutic use; D001299:Audiometry; D002648:Child; D002675:Child, Preschool; D003638:Deafness / Q000139:chemically induced*; D005260:Female; D005500:Follow-Up Studies; D006193:Haemophilus influenzae; D006801:Humans; D007223:Infant; D007275:Injections, Intravenous; D008297:Male; D008581:Meningitis / Q000188:drug therapy* / Q000401:mortality; D008583:Meningitis, Haemophilus / Q000188:drug therapy
D000667:Ampicillin