title: B lymphocytes in the guinea pig thymus are specifically localized in the central area.
abstract: Since the central area is an integral part of the guinea pig thymus, the cells in this area were compared with those in the thymic cortex and medulla in cryostat-sections by using methods for demonstration of E-, EA-, EAC-adherence and surface membrane immunoglobulins. In the extra cortical central area (ECCA) 15 to 25% of the lymphocytes showed EAC-adherence and 5 to 10% appeared to bear surface membrane immunoglobulins (SIg). In the lymph sinuses up to 70% of the lymphocytes were EAC- and SIg-positive. A small amount of EAC-adhering cells was present in the medulla of the central area. Cortical lymphocytes were EAC- and SIg-negative. From these results we conclude that in the guinea pig thymus B lymphocytes are specifically localized in the central area.
mesh_terms: D000818:Animals; D001402:B-Lymphocytes; D001666:Binding Sites, Antibody; D004950:Esterases / Q000378:metabolism; D006168:Guinea Pigs; D007104:Immune Adherence Reaction; D007074:Immunoglobulin G; D007075:Immunoglobulin M; D008297:Male; D010586:Phagocytes / Q000201:enzymology; D011947:Receptors, Antigen, B-Cell / Q000032:analysis; D013950:Thymus Gland / Q000166:cytology*
chemical_list: D007074:Immunoglobulin G; D007075:Immunoglobulin M; D011947:Receptors, Antigen, B-Cell; D004950:Esterases