title: Evaluation of intracardiac shunts.
abstract: This article will review the qualitative and quantitative methods of radionuclide evaluation of intracardiac shunts. Radionuclide angiocardiography of the cardiopulmonary system has proven adequate, with few exceptions, for qualitative detection of left-to-right and right-to-left intracardiac shunts. Numerous authors have reported on the detection of intracardiac shunts using qualitative methods such as rapid sequential visualization of nuclide angiocardiography using the scintillation camera with Polaroid, 35mm or 70mm film. Recent development of videotape storage systems and computers offers a quantitative technique of permanently recording the nuclide angiocardiogram and thus the capability for replay and analysis of the study. Quantitative analysis of the nuclide angiogram in the form of heart chamber dilution curves or pulmonary dilution curves permits 1) determination of the presence or absence of left-to-right, right-to-left, or bi-directional intracardiac shunts, including shunts which might go undetected using the qualitative techniques, 2) shunt location at the atrial or ventricular level, 3) determination of the functional status of a corrective left-to-right shunt, and 4) shunt quantitation. By quantitative analysis of the isotope dilution curves, it is possible to calculate the size of left-to-right or right-to-left intracardiac shunts (Qp/Qs ratio) to within 10% of the values obtained at cardiac catheterization.
mesh_terms: D000293:Adolescent; D000328:Adult; D002648:Child; D002675:Child, Preschool; D003102:Colloids; D005260:Female; D006321:Heart / Q000033:anatomy & histology / Q000196:embryology; D006343:Heart Septal Defects / Q000175:diagnosis*; D006344:Heart Septal Defects, Atrial / Q000175:diagnosis; D006345:Heart Septal Defects, Ventricular / Q000175:diagnosis; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007726:Krypton; D008297:Male; D011666:Pulmonary Valve Stenosis / Q000151:congenital / Q000175:diagnosis; D011877:Radionuclide Imaging / Q000295:instrumentation / Q000379:methods; D012709:Serum Albumin; D012711:Serum Albumin, Radio-Iodinated; D013455:Sulfur; D013667:Technetium; D013771:Tetralogy of Fallot / Q000175:diagnosis; D014188:Transposition of Great Vessels / Q000175:diagnosis; D014264:Tricuspid Valve Stenosis / Q000151:congenital / Q000175:diagnosis; D014980:Xenon Radioisotopes
chemical_list: D003102:Colloids; D012709:Serum Albumin; D012711:Serum Albumin, Radio-Iodinated; D014980:Xenon Radioisotopes; D007726:Krypton; D013455:Sulfur; D013667:Technetium