The loss of biological activity of 5-hydroxytryptamine creatinine sulphate.
5-Hydroxytryptamine creatinine sulphate loses its biological activity when maintained at room temperature. The loss of 5-HT activity (in stimulating sodium transport across frog skin) is greater than the loss of creatinine sulphate activity (inhibition of sodium transport).
D000818:Animals; D001693:Biological Transport, Active / Q000187:drug effects; D003404:Creatinine / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D004355:Drug Stability; D008027:Light; D011896:Rana temporaria; D012701:Serotonin / Q000494:pharmacology*; D012867:Skin / Q000187:drug effects* / Q000378:metabolism; D012964:Sodium / Q000378:metabolism; D013997:Time Factors
D012701:Serotonin; D012964:Sodium; D003404:Creatinine