[A new substituted benzamide with neuroleptic effects: lin 14 18 or sultopride].
After the research about Sulpiride, a new substituted benzamide has been studied. Although it was characterized by modest pharmacological effects in the neuroleptic identification tests, LIN 1418 turned out to have very interesting therapeutic properties. A study conducted with 50 cases, 30 of which were submitted a systematic pluridisciplinary control, leads to provisory conclusions as follows: 1) its psychotropic effects are powerful and constant; 2) its prevailing action is antipsychotic and desinhibiting altogether; 3) while LIN 1418 appears as successful with all psychoses, whether acute or chronic, up to now, the quality of its results in many chronic psychoses seems to be particularly remarkable; 4) its side-effects are those of most neuroleptics: its extrapyramidal symptoms being all the more obvious as the patient's "passivity" is less important.
D000328:Adult; D000368:Aged; D001549:Benzamides / Q000009:adverse effects / Q000627:therapeutic use*; D002986:Clinical Trials as Topic; D003702:Delusions / Q000188:drug therapy; D004341:Drug Evaluation; D006801:Humans; D008297:Male; D008875:Middle Aged; D010302:Parkinson Disease, Secondary / Q000139:chemically induced; D011618:Psychotic Disorders / Q000188:drug therapy*; D012559:Schizophrenia / Q000188:drug therapy; D013469:Sulpiride / Q000031:analogs & derivatives* / Q000627:therapeutic use; D014149:Tranquilizing Agents / Q000627:therapeutic use
D001549:Benzamides; D014149:Tranquilizing Agents; D013469:Sulpiride
Une nouvelle benzamide substituée á effets neuroleptiques: Le Lin. 14 18 ou sultopride.