Virus-like particles in Creutzfeldt-Jakob biopsy material.
In an electron microscopic study of brain biopsy material from 6 patients with Creutzfeldt-Jacob disease, virus-like particles resembling herpes have been seen. These particles were found only in reactive astrocytes. In 2 out of 6 Creutzfeldt-Jacob brain biopsies some profiles were filled with tubular structures resembling the nucleocapsid of paramyxovirus. The findings are compared with other neurological conditions.
D001253:Astrocytes / Q000382:microbiology / Q000648:ultrastructure; D001921:Brain / Q000382:microbiology; D007562:Creutzfeldt-Jakob Syndrome / Q000382:microbiology* / Q000473:pathology; D003711:Demyelinating Diseases / Q000382:microbiology; D004721:Endoplasmic Reticulum / Q000648:ultrastructure; D006801:Humans; D007181:Inclusion Bodies, Viral; D010252:Paramyxoviridae; D014764:Viral Proteins
D014764:Viral Proteins