Immunosuppression by hydroxystilbamidine isethionate, a lysosome-stabilizing, anti-proteolytic, antifungal drug.
Hydroxystilbamidine (HSB) is a potent suppressor of the plaque-forming cell response of mice injected with heterologous erythrocytes. HSB, given in varying doses and injection schedules, suppressed both the primary and secondary immune responses to bovine serum albumin. Apparently the effect is not simply a toxic effect on spleen cells, because there was no appreciable difference in cell numbers between control and HSB-treated mice. The effect of HSB was most apparent in the early phase of the immune respone.
D000818:Animals; D000917:Antibody Formation / Q000187:drug effects*; D004912:Erythrocytes / Q000276:immunology; D004926:Escherichia coli / Q000276:immunology; D005260:Female; D006462:Hemolytic Plaque Technique; D007114:Immunization; D007117:Immunization, Secondary; D007156:Immunologic Memory / Q000187:drug effects; D008070:Lipopolysaccharides; D008214:Lymphocytes / Q000276:immunology; D051379:Mice; D008808:Mice, Inbred CBA; D011135:Polysaccharides, Bacterial; D011233:Precipitin Tests; D012710:Serum Albumin, Bovine; D012756:Sheep / Q000276:immunology; D013154:Spleen / Q000166:cytology; D013266:Stilbamidines / Q000494:pharmacology*
D008070:Lipopolysaccharides; D011135:Polysaccharides, Bacterial; D013266:Stilbamidines; D012710:Serum Albumin, Bovine