Reduction in T-lymphocytes forming active rosettes in chronic marijuana smokers.
Rosettes formed by peripheral T- and B-lymphocytes were studied in 23 normal controls and 23 marijuana smokers. The mean percentage of cells forming B type rosettes were normal in both groups. The percentage of T cells forming rosettes was lower in the marijuana smokers, and 39% had values below 2 standard deviations of the mean of the normal control group. These observations suggest some alteration in some T cells in some marijuana smokers.
D000293:Adolescent; D000328:Adult; D001402:B-Lymphocytes / Q000187:drug effects / Q000276:immunology; D002188:Cannabis / Q000494:pharmacology*; D005260:Female; D006801:Humans; D007104:Immune Adherence Reaction; D008297:Male; D013601:T-Lymphocytes / Q000187:drug effects / Q000276:immunology*