title: High power argon laser treatment via standard endoscopes. I. A preliminary study of efficacy in control of experimental erosive bleeding.
abstract: With minimal transmission loss a high power argon laser (10 w) was coupled to a waveguide consisting of a flexible, single, coated, quartz fiber encased in a protective polyethylene tube. This waveguide can be passed down the biopsy channel of any standard fiberoptic endoscope. An aiming light improves accuracy. Safety devices were developed to protect the subject and the operator. Each of 8 heparinized mongrel dogs had three superficial erosions created endoscopically in the fundal gland mucosa by a jet of warm 0.1 N HC1. In each animal two lesions were photocoagulated with the laser and the third was left as a control. The animals were killed at 0, 4, 7, 10, and 14 days, and the erosions were examined histologically. By 14 days all lesions were covered by normal surface epithelium. Parietal and chief cells had returned to untreated erosions at 14 days but not to all lasered lesions. Only rarely did the lasered lesions penetrate through the muscularis mucosae into the submucosa. High power argon laser photocoagulation is now feasible through standard endoscopes. These data are sufficiently promising to encourage further evaluation of laser photocoagulation in a variety of animal models.
mesh_terms: D000818:Animals; D001128:Argon; D004195:Disease Models, Animal; D004285:Dogs; D005336:Fiber Optic Technology; D005753:Gastric Mucosa / Q000473:pathology; D006471:Gastrointestinal Hemorrhage / Q000473:pathology / Q000601:surgery*; D005773:Gastroscopy; D053685:Laser Therapy; D007834:Lasers; D013270:Stomach / Q000473:pathology
chemical_list: D001128:Argon