[Condition of lymphoid tissue and characteristics of development of antitoxin immunity during an experimental course of methotrexate treatment].
Methotrexate administered to albino mice in a dose of 0.5 mg/kg for a period of 10 days caused significant (two period) changes in the central and peripheral immunocompetent tissue. During the first--destructive--period there occurred a marked reduction in the weight of the spleen and the thymus, a cut in the count of the nuclear cells in them, and also a significant depletion of the cellular composition of the lymphoid organs. Suspension of the cytostatic was followed by a gradual restoration of all the indices under study, slower in the thymus than in the spleen. In the animals immunized with the tetanus toxoid against the background of the methotrexate administration all the changes in the lymphoid organs developed under a preponderant influence of the cytostatic agent; the action of the antigen was depressed during the whole experiment. Specific antibodies appeared in the blood of these animals later and their titres were lower than in control; experimental mice were also less resistant to tetanus toxin.
D000818:Animals; D000917:Antibody Formation / Q000187:drug effects*; D008727:Methotrexate / Q000494:pharmacology*; D051379:Mice; D009504:Neutrophils / Q000187:drug effects; D009929:Organ Size / Q000187:drug effects; D010950:Plasma Cells / Q000187:drug effects; D013154:Spleen / Q000166:cytology / Q000187:drug effects*; D013601:T-Lymphocytes / Q000187:drug effects; D013744:Tetanus Toxin; D013745:Tetanus Toxoid; D013950:Thymus Gland / Q000166:cytology / Q000187:drug effects*
D013744:Tetanus Toxin; D013745:Tetanus Toxoid; D008727:Methotrexate
Sostoianie limfoidnoĭ tkani i osobennosti formirovaniia antitoksicheskogo immuniteta pri kursovom primenenii metotreksata v éksperimente