Clinical observations on treatment of alkylmercury poisoning in hospital patients.
Twenty-six patients suffering from methylmercury poisoning were treated by different therapeutic regimes. Seven received penicillamine or N-acetyl-d-L-penicillamine, 10 were treated with dimercaprol sulfonate and 9, who could not be treated, were given a placebo and were used as controls. Penicillamine, N-acetyl-d-L-penicillamine, and dimercaprol sulfonate reduced the blood level of mercury and increased its urinary excretion. No appreciable clinical improvement was noticed among the severe or very severe cases, while mild or moderate cases improved clinically irrespective of the treatment given.
D000293:Adolescent; D000328:Adult; D000479:Alkylmercury Compounds / Q000506:poisoning*; D002648:Child; D005260:Female; D006801:Humans; D008297:Male; D008628:Mercury / Q000378:metabolism; D008630:Mercury Poisoning / Q000188:drug therapy* / Q000378:metabolism; D008875:Middle Aged; D010396:Penicillamine / Q000031:analogs & derivatives / Q000627:therapeutic use
D000479:Alkylmercury Compounds; D008628:Mercury; D010396:Penicillamine