[Silicone embolism, fat embolism, and fibrin thrombosis in dogs after extracorporeal circulation using a bubble-oxygenator (author's transl)].
Following extracorporeal circulation with a bubble oxygenator (Rygg-Kyvsgaard) silicone emboli were found in the brain-and-kidney-capillaries of all dogs evaluated. There was no obvious correlation between intensity of silicone embolism and pump time. No cellular reaction was seen around the anti-foam agent. Occasionally single small areas of embolic brain damage were found. During extracorporeal circulation and within a recovery period up to one hour no silicone excretion through the kidneys could be demonstrated. Systemic fat embolism occurred less frequent than previously reported. Use of a filter in the cardiotomy suction line reduced its intensity further. In neither of the various organs examined, disseminated intravascular thrombosis could be found.
D000818:Animals; D001921:Brain / Q000098:blood supply; D002196:Capillaries / Q000473:pathology; D004285:Dogs; D004617:Embolism / Q000209:etiology* / Q000473:pathology; D004620:Embolism, Fat / Q000209:etiology / Q000473:pathology; D005112:Extracorporeal Circulation / Q000009:adverse effects*; D005374:Filtration; D007668:Kidney / Q000098:blood supply; D007678:Kidney Glomerulus / Q000473:pathology; D008833:Microcirculation; D010106:Oxygenators / Q000009:adverse effects*; D011655:Pulmonary Embolism / Q000209:etiology; D012828:Silicones / Q000009:adverse effects / Q000378:metabolism
D012828:Silicones
Silikonembolien, Fettembolien und intravasale Fibringerinnsel bei Hunden nach extrakorporaler Zirkulation mit einem Gas-dispersionsoxygenator