T rosettes in alcoholic cirrhosis of the liver.
Thirty patients with alcoholic cirrhosis of the liver were studied for in vivo and in vitro correlates of cellular immunity. Seventy-seven percent failed to be sensitized to dinitrochlorobenzene, indicating impairment of the in vivo cellular immune response. A significant decrease in the number of T-rosette-forming cells was observed in this group of patients (.01 smaller than P smaller than .025). This finding suggests that the active T-rosette test is a valuable tool in detecting partial alterations in cell-mediated immunity in alcoholic cirrhosis of the liver. Our results also suggest that rosette formation is a more sensitive indicator of cell-mediated immunity than phytohemagglutinin-stimulated blastogenesis in patients with alcoholic cirrhosis of the liver.
D000437:Alcoholism / Q000150:complications*; D000946:Antigens, Fungal / Q000008:administration & dosage; D002176:Candida albicans / Q000276:immunology; D005260:Female; D006801:Humans; D006968:Hypersensitivity, Delayed / Q000276:immunology; D007104:Immune Adherence Reaction; D007111:Immunity, Cellular; D007114:Immunization; D007258:Informed Consent; D037102:Lectins; D008099:Liver / Q000276:immunology; D008103:Liver Cirrhosis / Q000276:immunology*; D008213:Lymphocyte Activation; D008297:Male; D009578:Nitrobenzenes / Q000276:immunology; D012867:Skin / Q000276:immunology; D012882:Skin Tests; D013299:Streptodornase and Streptokinase / Q000276:immunology; D013601:T-Lymphocytes / Q000276:immunology*; D013997:Time Factors
D000946:Antigens, Fungal; D037102:Lectins; D009578:Nitrobenzenes; D013299:Streptodornase and Streptokinase