Immunodeficiency diseases. I. T-lymphocyte precursors and T-lymphocyte differentiation in partial Di George syndrome.
Immunological and pathological studies in a case of partial Di George syndrome revealed an absence of parathyroids, a major hypoplasia of thymus but a relatively moderate decrease in peripheral T-lymphocyte numbers and functions. After in vitro incubation with normal thymus extracts, a normal proportion of bone marrow cells was induced to differentiate into cells with characteristics of T lymphocytes, thus establishing the presence of T-cell precursors in the patient's bone marrow.
D000937:Antigen-Antibody Reactions; D000961:Antilymphocyte Serum / Q000494:pharmacology; D001853:Bone Marrow / Q000276:immunology; D001854:Bone Marrow Cells; D003208:Concanavalin A / Q000494:pharmacology; D005260:Female; D006801:Humans; D007153:Immunologic Deficiency Syndromes / Q000276:immunology*; D007223:Infant; D008198:Lymph Nodes / Q000473:pathology; D008213:Lymphocyte Activation / Q000187:drug effects*; D010280:Parathyroid Glands / Q000002:abnormalities* / Q000276:immunology; D013154:Spleen / Q000473:pathology; D013577:Syndrome; D013601:T-Lymphocytes / Q000276:immunology*; D013950:Thymus Gland / Q000002:abnormalities* / Q000276:immunology; D014165:Transfer Factor / Q000494:pharmacology
D000961:Antilymphocyte Serum; D014165:Transfer Factor; D003208:Concanavalin A