The origin of blood 5-hydroxyindoleacetic acid following L-hydrazine-alpha-methyldopa (MK-486).
Blood 5-HIAA-14C levels derived from exogenous D,L-5-HTP-14C were investigated in normal, sham-operated and nephrectomized rats pretreated with MK-486 and probenecid (200 mg/kg i.p.). Blood 5-HIAA-14C levels decreased in nephrectomized rats following probenecid. Peripheral decarboxylase inhibition by MK-486 was enhanced by both probenecid and nephrectomy. Increased penetration of 5-HTP into brain occurred following probenecid. Thr results indicate that the following MK-486 about 20% of the blood 5-HIAA-14C derived from 5-HTP-14C in rats originates in the CNS.
D006916:5-Hydroxytryptophan / Q000378:metabolism; D000311:Adrenal Glands / Q000378:metabolism; D000818:Animals; D001923:Brain Chemistry / Q000187:drug effects; D002230:Carbidopa / Q000494:pharmacology*; D003864:Depression, Chemical; D006834:Hydrazines / Q000494:pharmacology*; D006897:Hydroxyindoleacetic Acid / Q000097:blood*; D007668:Kidney / Q000502:physiology; D008099:Liver / Q000378:metabolism; D008297:Male; D011339:Probenecid / Q000494:pharmacology; D051381:Rats; D012701:Serotonin / Q000378:metabolism
D006834:Hydrazines; D012701:Serotonin; D006897:Hydroxyindoleacetic Acid; D006916:5-Hydroxytryptophan; D002230:Carbidopa; D011339:Probenecid