Modification of postirradiation hydroproteolytic activity of rat's pancreas by some drugs.
Influence of Trasylol and morphine on hydroproteolytic activity of rat's pancreas was investigated. Trasylol, administered in vivo, caused normalization of activity of some pancreatic enzymes in the rats single and fractionated irradiated. In vitro, however, Trasylol did not affect the catheptic (pH 5.4) and amylolytic activity of the pancreas. After in vivo administration of morphine, the return to control values of amylolytic activity in the serum of single irradiated animals was observed.
D000135:Acid Phosphatase / Q000032:analysis; D000681:Amylases / Q000032:analysis; D000818:Animals; D007611:Aprotinin / Q000494:pharmacology*; D002403:Cathepsins / Q000032:analysis; D005260:Female; D005966:Glucuronidase / Q000032:analysis; D008049:Lipase / Q000032:analysis; D009020:Morphine / Q000494:pharmacology*; D010179:Pancreas / Q000187:drug effects* / Q000201:enzymology / Q000528:radiation effects; D011830:Radiation Effects; D051381:Rats
D009020:Morphine; D007611:Aprotinin; D008049:Lipase; D000135:Acid Phosphatase; D000681:Amylases; D005966:Glucuronidase; D002403:Cathepsins