Synthesis and antiinflammatory activity of some 1,6-methano[10]annuleneacetic acids.
Some new approaches to the 1,6-methano[10]annulene system are described. The routes were used to prepare 1,6-methano[10]annulene-3-acetic acid and the alpha-methyl analog. The compounds showed antinflammatory and analgesic activity, though less than that of corresponding naphthalene compounds; the possible effect of the chirality of the annulene on the observed biological activity is discussed.
D000085:Acetates / Q000138:chemical synthesis / Q000627:therapeutic use; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000138:chemical synthesis* / Q000627:therapeutic use; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000138:chemical synthesis / Q000627:therapeutic use; D001241:Aspirin / Q000627:therapeutic use; D001952:Bridged-Ring Compounds / Q000138:chemical synthesis* / Q000627:therapeutic use; D002351:Carrageenan; D004487:Edema / Q000139:chemically induced / Q000188:drug therapy; D051379:Mice; D010653:Phenylbutazone / Q000627:therapeutic use; D051381:Rats
D000085:Acetates; D000893:Anti-Inflammatory Agents; D000894:Anti-Inflammatory Agents, Non-Steroidal; D001952:Bridged-Ring Compounds; D002351:Carrageenan; D010653:Phenylbutazone; D001241:Aspirin