Effect of low-dose heparin on incidence of postoperative thrombosis in orthopaedic patients.
In a double-blind study, using matched controls, thrombo-embolic prophylaxis with subcutaneous low-dose heparin was studied in 25 patients admitted for orthopaedic surgery. Deep vein thrombosis (DVT) was detected by clinical assessment and by the 125I-fibrinogen leg-scanning technique. As a control the T-1/2 of the 125I-fibrinogen was measured. Six of the 13 patients in the control group and one in the heparin-treated group developed deep vein thrombosis within the first eight postoperative days.
D000368:Aged; D002986:Clinical Trials as Topic; D005260:Female; D005340:Fibrinogen; D006493:Heparin / Q000008:administration & dosage / Q000627:therapeutic use*; D006801:Humans; D007279:Injections, Subcutaneous; D007457:Iodine Radioisotopes; D008297:Male; D008875:Middle Aged; D011183:Postoperative Complications / Q000517:prevention & control*; D011877:Radionuclide Imaging; D013924:Thrombophlebitis / Q000175:diagnosis / Q000188:drug therapy / Q000517:prevention & control*
D007457:Iodine Radioisotopes; D005340:Fibrinogen; D006493:Heparin