alpha-Methylnoradrenaline induced hypotension and bradycardia after administration into the area of the nucleus tractus solitarii.
Bilateral injections of alpha-methylnoradrenaline into the area of the nucleus tractus solitarii of the brain stem caused a dose-dependent decrease of systemic arterial blood pressure and heart rate of anesthetized rats. The effects were prevented and even reversed by a preceding injection of the alpha-adrenoceptor blocking agent phentolamine. Pressor doses of angiotensin II and of arginine-vasopressin at the same site failed to drcrease blood pressure and heart rate.
D000804:Angiotensin II / Q000494:pharmacology; D000818:Animals; D001127:Arginine Vasopressin / Q000494:pharmacology; D001794:Blood Pressure / Q000187:drug effects*; D003864:Depression, Chemical; D006339:Heart Rate / Q000187:drug effects*; D008297:Male; D008526:Medulla Oblongata; D009424:Nervous System Physiological Phenomena; D009434:Neural Pathways / Q000502:physiology*; D008771:Nordefrin / Q000494:pharmacology; D009638:Norepinephrine / Q000031:analogs & derivatives*; D010646:Phentolamine / Q000494:pharmacology; D051381:Rats; D013997:Time Factors
D000804:Angiotensin II; D001127:Arginine Vasopressin; D008771:Nordefrin; D009638:Norepinephrine; D010646:Phentolamine