The use of haloperidol for treatment of postoperative nausea and vomiting--a double-blind placebo-controlled trial.
Sixty-two postoperative patients were admitted to a double-blind study to compare the therapeutic effectiveness of a single intramuscular injection of 1 mg of haloperidol with that of a placebo for the relief of vomiting and nausea following surgical procedures. Significantly fewer patients continued to vomit or experience nausea in the haloperidol-treatment group than in the placebo-treatment group. No statistically or clinically significant change in vital signs occurred in the haloperidol-treatment group. No serious side effect occurred in either group.
D000005:Abdomen / Q000601:surgery; D000293:Adolescent; D000328:Adult; D000368:Aged; D000769:Anesthesia, Inhalation; D000777:Anesthetics; D002986:Clinical Trials as Topic; D003120:Colorado; D003521:Cyclopropanes; D005260:Female; D006220:Haloperidol / Q000008:administration & dosage / Q000627:therapeutic use*; D006801:Humans; D007273:Injections, Intramuscular; D008297:Male; D008875:Middle Aged; D009325:Nausea / Q000188:drug therapy* / Q000453:epidemiology; D009609:Nitrous Oxide; D010100:Oxygen; D010919:Placebos; D011183:Postoperative Complications / Q000188:drug therapy*; D013874:Thiopental; D014621:Vagina / Q000601:surgery; D014839:Vomiting / Q000188:drug therapy* / Q000453:epidemiology
D000777:Anesthetics; D003521:Cyclopropanes; D010919:Placebos; D006220:Haloperidol; D013874:Thiopental; D009609:Nitrous Oxide; D010100:Oxygen