Rapamycin (AY-22,989), a new antifungal antibiotic. II. Fermentation, isolation and characterization.
Rapamycin is a new antifungal antibiotic produced by Streptomyces hygroscopicus NRRL 5491. It was isolated from the mycelium by solvent extraction, purified by silica gel column chromatography and crystallized as a colorless solid which melts at 183 approximately to 185 degrees C and has the empirical formula C56H89NO14. From its characteristic ultraviolet absorption spectrum rapamycin can be classified as a triene. It is highly active against various Candida species, especially Candida albicans. Its activity is compared with that of amphotericin B, candicidin and nystatin.
D000666:Amphotericin B / Q000494:pharmacology; D000935:Antifungal Agents / Q000302:isolation & purification* / Q000494:pharmacology; D001431:Bacteriological Techniques; D002174:Candicidin / Q000494:pharmacology; D002175:Candida / Q000187:drug effects; D002176:Candida albicans / Q000187:drug effects; D005285:Fermentation; D009761:Nystatin / Q000494:pharmacology; D011090:Polyenes / Q000302:isolation & purification / Q000494:pharmacology; D013302:Streptomyces / Q000032:analysis*
D000935:Antifungal Agents; D011090:Polyenes; D009761:Nystatin; D002174:Candicidin; D000666:Amphotericin B