Experimental model of oral antityphoid vaccination with live streptomycin-dependent Salmonella typhimurium in C57BL/6 mice.
The present experimental model offered the opportunity to study particular aspects concerning the avirulence stability of live streptomycin-dependent (Sm D) Salmonella vaccines, under conditions resembling human enteric fever. The results seem to indicate that, in practice, the risk of reversion to a virulent form during oral antityphoid vaccination with Sm D strains remains slight even after the interruption of concomitant streptomycin administration.
D000818:Animals; D004195:Disease Models, Animal; D005243:Feces / Q000382:microbiology; D005827:Genetics, Microbial; D006801:Humans; D051379:Mice; D008810:Mice, Inbred C57BL; D012486:Salmonella typhimurium / Q000378:metabolism / Q000472:pathogenicity*; D013307:Streptomycin / Q000008:administration & dosage / Q000378:metabolism* / Q000494:pharmacology; D014435:Typhoid Fever / Q000517:prevention & control*; D014436:Typhoid-Paratyphoid Vaccines / Q000008:administration & dosage; D014611:Vaccination; D014774:Virulence
D014436:Typhoid-Paratyphoid Vaccines; D013307:Streptomycin