title: [Antibiotics in newborns and young infants].
abstract: Localized and generalized infections in newborns nowadays are mostly due to gram negative bacteria (E. coli, Klebsiella, Enterobacter, Pseudomonas pyocyanea, Serratia marcescens et al.). Unspecific treatment causes an increasing rate of resistance, as shown by an account of our own experiences. Tobramycin, Gentamycin, and Cefazolin appear to be particularly promising antibiotics to avoid the development of resistance though their pharmacokinetics in the newborn have to be considered carefully. Based on the determination of serum levels of Tobramycin and Amoxycillin in newborns general recommendations for the dosage of these new antibiotics are given.
mesh_terms: D000328:Adult; D000367:Age Factors; D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D002512:Cephalothin / Q000627:therapeutic use; D004352:Drug Resistance, Microbial; D004756:Enterobacteriaceae Infections / Q000188:drug therapy; D004927:Escherichia coli Infections / Q000188:drug therapy; D005839:Gentamicins / Q000627:therapeutic use; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007232:Infant, Newborn, Diseases / Q000188:drug therapy*; D007710:Klebsiella Infections / Q000188:drug therapy; D011552:Pseudomonas Infections / Q000188:drug therapy; D012706:Serratia marcescens
chemical_list: D000900:Anti-Bacterial Agents; D005839:Gentamicins; D002512:Cephalothin
vernacular_title: Antibiotika beim Neugeborenen und jungen Säugling