title: Factor(s) from Ehrlich Ascites cells responsible for delayed rejection of skin allografts in mice and its assay on lymphocytes in vitro.
abstract: Cell free Ehrlich ascitic fluid from tumor bearing mice and the nutrient medium from Ehrlich cells maintained in vitro contain a factor(s) which when transferred to normal mice delays rejection of skin allografts and enhances the growth of a syngeneic transplantable tumor. Both types of prepartions inhibit DNA synthesis in lymphocytes stimulated by PHA. These results suggest that Ehrlich tumor cells release a factor which impairs the normal lymphocytic response to allo and tumor antigens.
mesh_terms: D000818:Animals; D001202:Ascitic Fluid / Q000276:immunology; D002277:Carcinoma / Q000276:immunology; D002286:Carcinoma, Ehrlich Tumor / Q000276:immunology*; D003470:Culture Media; D004261:DNA Replication / Q000187:drug effects; D006084:Graft Rejection / Q000276:immunology*; D037102:Lectins / Q000494:pharmacology; D008214:Lymphocytes / Q000276:immunology*; D051379:Mice; D008807:Mice, Inbred BALB C; D008809:Mice, Inbred C3H; D008810:Mice, Inbred C57BL; D016038:Skin Transplantation; D013936:Thymidine / Q000378:metabolism; D014184:Transplantation, Homologous; D014316:Tritium
chemical_list: D003470:Culture Media; D037102:Lectins; D014316:Tritium; D013936:Thymidine