title: Pharmacological analysis of slow potentials recorded in frog olfactory bulb during natural stimulation.
abstract: Pharmacological agents (strychnine, picrotoxin, pentobarbital, chloralose, GABA, penicillin, morphine) were used to investigate the nature of the slow potential recorded in the frog olfactory bulb in response to natural stimulation. Three possible hypotheses were tested: 1) The slow potential is neuroglial in nature; 2) it is the analog of the dorsal-root potential of the spinal cord and reflects depolarization of primary afferents arising in the terminals of the olfactory nerve and responsible for presynaptic inhibition in the frog olfactory bulb; 3) the slow potential reflects postsynaptic processes. The results showed great similarity between changes in the slow and dorsal-root potentials of the spinal cord in response to the action of pharmacological agents. However, the slow potential is evidently a complex response and incorporates at least one other component - depolarization of the dendrites of unknown nature.
mesh_terms: D000200:Action Potentials / Q000187:drug effects*; D000818:Animals; D001001:Anura; D002698:Chloralose / Q000494:pharmacology; D009020:Morphine / Q000494:pharmacology; D009830:Olfactory Bulb / Q000187:drug effects*; D010400:Penicillin G / Q000494:pharmacology; D010424:Pentobarbital / Q000494:pharmacology; D010852:Picrotoxin / Q000494:pharmacology; D011896:Rana temporaria; D013331:Strychnine / Q000494:pharmacology; D005680:gamma-Aminobutyric Acid / Q000494:pharmacology
chemical_list: D002698:Chloralose; D009020:Morphine; D010400:Penicillin G; D010424:Pentobarbital; D010852:Picrotoxin; D013331:Strychnine; D005680:gamma-Aminobutyric Acid