Effect of tilorone hydrochloride on the lymphoid and interferon responses of athymic mice.
Nude athymic mice, which lack T-lymphocytes and are unable to mount a cellular immune response, failed to develop the lymphopenia so characteristically produced by a 100 mg/kg oral dose of tilorone hydrochloride in normal mice. The antiviral activity detected in athymic mice 18 hr after a 150 mg/kg oral dose of tilorone was significant, although somewhat less than that found in treated normal mice. These findings suggest that tilorone hydrochloride has a specific effect on T-lymphocytes that accounts for its effect on cellular immunity, but that its antiviral activity is not primarily mediated by T-lymphocytes.
D000818:Animals; D005449:Fluorenes / Q000494:pharmacology*; D007372:Interferons / Q000096:biosynthesis*; D008231:Lymphopenia / Q000139:chemically induced; D051379:Mice; D008819:Mice, Nude; D013601:T-Lymphocytes / Q000187:drug effects* / Q000276:immunology; D013994:Tilorone / Q000494:pharmacology*
D005449:Fluorenes; D007372:Interferons; D013994:Tilorone