Immediate short-time effects of ethacrynic acid on frog gastric mucosa in chloride-free solutions.
The presence of ethacrynic acid in the nutrient sulphate solution produces, generally in less than 3 min, a decrease in resistance accompanied by an increase in transmucosal PD. These results strongly suggest that the dominant effect of ethacrynic acid is not on the Na+ pathway of the nutrient membrane, but without further knowledge of the resistance of other ionic pathways, it cannot be inferred whether the effect predominates on the K+ pathway as in Cl- media.
D000818:Animals; D002712:Chlorides / Q000378:metabolism; D004553:Electric Conductivity / Q000187:drug effects; D004976:Ethacrynic Acid / Q000494:pharmacology*; D066298:In Vitro Techniques; D008564:Membrane Potentials / Q000187:drug effects*; D011188:Potassium / Q000378:metabolism; D011894:Rana pipiens; D013997:Time Factors
D002712:Chlorides; D004976:Ethacrynic Acid; D011188:Potassium