Proposal concerning mechanism of evolution of the genome of Escherichia coli.
Many pairs of genes whose gene products are functionally related lie either 90 degrees or 180 degrees apart on the circular map of the E. coli chromosome. A mechanism of evolution is proposed that involves two sequential duplications of an ancestral genome, followed by mutation and divergence of function of replicate genes.
D005075:Biological Evolution; D002874:Chromosome Mapping; D002876:Chromosomes, Bacterial / Q000032:analysis / Q000378:metabolism; D004261:DNA Replication; D004269:DNA, Bacterial / Q000032:analysis; D004270:DNA, Circular / Q000032:analysis; D004926:Escherichia coli / Q000032:analysis / Q000378:metabolism*; D005787:Gene Frequency; D005796:Genes; D009876:Operon
D004269:DNA, Bacterial; D004270:DNA, Circular