Affective disorder: studies with amine precursors.
The authors assessed the clinical antidepressant effects of L-tryptophan given alone and in combination with L-dopa in 12 patients with a diagnosis of primary affective disorder; Preliminary results did not demonstrate an antidepressant response when L-dopa was combined with L-tryptophan. Also, the results did not support the catecholamine or biogenic amine hypotheses of affective disorder.
D000328:Adult; D000928:Antidepressive Agents; D001679:Biogenic Amines / Q000378:metabolism; D001714:Bipolar Disorder / Q000188:drug therapy* / Q000378:metabolism; D001921:Brain / Q000378:metabolism; D001923:Brain Chemistry / Q000187:drug effects; D002986:Clinical Trials as Topic; D003863:Depression / Q000188:drug therapy* / Q000378:metabolism; D004341:Drug Evaluation; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D007980:Levodopa / Q000494:pharmacology / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D008954:Models, Biological; D010919:Placebos; D012075:Remission, Spontaneous; D014364:Tryptophan / Q000494:pharmacology / Q000627:therapeutic use*
D000928:Antidepressive Agents; D001679:Biogenic Amines; D010919:Placebos; D007980:Levodopa; D014364:Tryptophan