title: Management of amputation-stump breakdown.
abstract: Seven cases of above-knee amputation stump breakdown following surgery for arteriosclerosis obliterans were successfully treated with Travase ointment. (Bacillus subtilis proteinase). Rehabilitation was facilitated because secondary closure of the previously infected necrotic wounds could be more rapidly undertaken.
mesh_terms: D000287:Administration, Topical; D000368:Aged; D000672:Amputation Stumps; D001161:Arteriosclerosis / Q000150:complications; D003646:Debridement; D048909:Diabetes Complications; D004926:Escherichia coli / Q000302:isolation & purification; D005734:Gangrene / Q000601:surgery; D006801:Humans; D007866:Leg / Q000098:blood supply; D008297:Male; D008875:Middle Aged; D011183:Postoperative Complications; D013210:Staphylococcus / Q000302:isolation & purification; D013291:Streptococcus / Q000302:isolation & purification; D013381:Subtilisins / Q000627:therapeutic use*; D014945:Wound Healing; D014946:Wound Infection / Q000188:drug therapy* / Q000382:microbiology
chemical_list: C023177:sultilains; D013381:Subtilisins