Genetic control of B-cell responses. I. Selective unresponsiveness to lipopolysaccharide.
Spleen cells from C3H/HeJ mice fail to develop both proliferative responses and increased polyclonal antibody secretion in the presence of concentrations of the B-cell mitogen lipopolysaccharide that are optimal for the induction of B-cell responses in conventional strains. This unresponsiveness is selective for lipopolysaccharide, since C3H/HeJ spleen cells respond normally to two other polyclonal B-cell activators-dextran-sulphate and purified protein derivative of tuberculin. These findings are interpreted as indicating a selective defect in the B-cell subpopulation that responds to lipopolysaccharides in conventional strains.
D000201:Activation Analysis; D000818:Animals; D000917:Antibody Formation / Q000187:drug effects; D000941:Antigens; D001402:B-Lymphocytes / Q000276:immunology*; D002455:Cell Division / Q000187:drug effects; D002999:Clone Cells; D003911:Dextrans; D004926:Escherichia coli; D008070:Lipopolysaccharides / Q000494:pharmacology*; D051379:Mice; D008809:Mice, Inbred C3H; D011135:Polysaccharides, Bacterial / Q000494:pharmacology*; D013154:Spleen / Q000166:cytology; D014373:Tuberculin
D000941:Antigens; D003911:Dextrans; D008070:Lipopolysaccharides; D011135:Polysaccharides, Bacterial; D014373:Tuberculin