title: [Toxicity of benzhydrylurea under experimental conditions].
abstract: Benzhydrylurea, which displays an anticonvulsant action and is of low acute toxicity in capable after a 3-month administration to rats to inhibit the growth of male-rats, intensify the excretion of protein with the urine, raise the blood sugar level (with its single administration--to reduce), provoke dystrophic changes in the liver, kidneys and central nervous system. Following a 1--3-week introduction of the substance guinea pigs and cats demonstrate hemorrhagic erosions in the stomach and small intestine (but not rabbits, dogs and rats), the appearance of pathological forms of erythrocytes, while guinea pigs suffer from leucopoietic disorders.
mesh_terms: D000818:Animals; D001284:Atrophy; D001559:Benzhydryl Compounds / Q000009:adverse effects / Q000633:toxicity*; D001921:Brain / Q000473:pathology; D001927:Brain Diseases / Q000139:chemically induced; D002415:Cats; D056486:Chemical and Drug Induced Liver Injury; D004285:Dogs; D005260:Female; D006471:Gastrointestinal Hemorrhage / Q000139:chemically induced; D006130:Growth Disorders / Q000139:chemically induced; D006168:Guinea Pigs; D006943:Hyperglycemia / Q000139:chemically induced; D007668:Kidney / Q000473:pathology; D007674:Kidney Diseases / Q000139:chemically induced; D008099:Liver / Q000473:pathology; D008297:Male; D010671:Phenylurea Compounds / Q000633:toxicity*; D011507:Proteinuria / Q000139:chemically induced; D011817:Rabbits; D051381:Rats
chemical_list: D001559:Benzhydryl Compounds; D010671:Phenylurea Compounds
vernacular_title: O toksichnosti benzgidrilmocheviny v eksperimente