Complement-mediated bactericidal system: evidence for a new pathway of complement action.
The early components of human complement (C1, C4, and C2) plus certain serum euglobulins will kill pathogenic strains of Shigella sonnei. Serum from patients with hereditary C3 deficiencies and specific antiserums to C3, C5, and C6 were utilized to demonstrate the absence of requirements for late-acting complement components in this unusual bactericidal system.
D000907:Antibodies, Bacterial; D001433:Bacteriolysis; D003172:Complement C1 / Q000502:physiology; D003176:Complement C3 / Q000502:physiology; D003181:Complement C4 / Q000502:physiology; D003182:Complement C5 / Q000502:physiology; D003183:Complement C6 / Q000502:physiology; D003165:Complement System Proteins / Q000502:physiology*; D008297:Male; D012477:Salmonella enteritidis; D012712:Serum Globulins / Q000502:physiology; D012764:Shigella sonnei
D000907:Antibodies, Bacterial; D003172:Complement C1; D003176:Complement C3; D003181:Complement C4; D003182:Complement C5; D003183:Complement C6; D012712:Serum Globulins; D003165:Complement System Proteins