title: A controlled, randomized trial of highly selective vagotomy versus selective vagotomy and pyloroplasty in the treatment of duodenal ulcer.
abstract: The results of highly selective vagotomy without drainage and selective vagotomy with pyloroplasty for duodenal ulcer were compared in a randomized, controlled trial of a series of 100 patients. The frequency of dumping, diarrhoea, and epigastric fullness was significantly lower after highly selective (6, 6, and 8 percent) than after selective vagotomy (30, 20, and 28 percent) one year after the operations. Recurrent and persisting duodenal ulcers appearing from one to four years after the operations were significantly more frequent after highly selective (22 percent) than after selective vagotomy (8 percent). No significant relationships were found between recurrent ulceration and gastric acid secretion measurements after the two operations. The Hollander response was early positive in 28 percent and late positive in 30 percent of the patients subjected to highly selective vagotomy, while the corresponding figures after selective vagotomy were 26 and 32 percent. The overall clinical results of the two operations were not different according to the classification of Visick. Excluding the patients with recurrence resulted in significantly better clinical results after highly selective vagotomy.
mesh_terms: D000328:Adult; D002986:Clinical Trials as Topic; D003967:Diarrhea / Q000209:etiology; D004381:Duodenal Ulcer / Q000601:surgery*; D005260:Female; D005500:Follow-Up Studies; D005750:Gastric Juice / Q000378:metabolism; D005755:Gastrins / Q000097:blood; D006632:Histamine; D006801:Humans; D007328:Insulin; D008297:Male; D008875:Middle Aged; D011183:Postoperative Complications; D011708:Pylorus / Q000601:surgery*; D012008:Recurrence; D014628:Vagotomy / Q000379:methods*
chemical_list: D005755:Gastrins; D007328:Insulin; D006632:Histamine