[The influence on pedicle flap blood supply and necrosis rate of plastic displacement with pentoxifylline and dextran 40].
Using a standardized procedure we have experimented on rats in order to examine the rate of necrosis in pedicle flaps in conjunction with 3,7-dimethyl-1-(5-oxo-hexyl)-xanthine (pentoxifyline, Trental) and dextran 40. Compared with the control group and that treated with dextran 40 the group treated with Trental showed significant decrease in necroses. The influence of drugs on blood supply demonstrated in this srudy as being significant is discussed.
D000818:Animals; D003911:Dextrans / Q000494:pharmacology*; D005260:Female; D009336:Necrosis / Q000473:pathology / Q000517:prevention & control*; D051381:Rats; D012039:Regional Blood Flow / Q000187:drug effects*; D012867:Skin / Q000098:blood supply; D016038:Skin Transplantation; D014022:Tissue Survival / Q000187:drug effects; D014182:Transplantation, Autologous; D014665:Vasodilator Agents / Q000494:pharmacology*; D014970:Xanthines / Q000494:pharmacology*
D003911:Dextrans; D014665:Vasodilator Agents; D014970:Xanthines
Beeinflussung der Lappendurchblutung and Nekroserate nach Verschiebeschwenkplastik durch Pentoxifylin and Dextran 40