The immune response of mice to phiX174. The potentiation of B-cell immunity and the suppression of T-cell help by pertussis vaccine.
The primary and secondary responses to phiX174 have been studied in T cell-deprived (T- minus) and control CBA mice including sham-operated (T+) and normal mice. The effect of pertussis on the immune response of these mice has been measured. It is concluded that: (1) the gammaG and memory responses to phiX are produced in T- minus mice even though greatly reduced in comparison with T+ and normal mice; (2) pertussis appears to enhance the gammaG response in T- minus mice while suppressing it in T+ and normal mice.
D000276:Adjuvants, Immunologic; D000818:Animals; D000917:Antibody Formation; D000921:Antibody-Producing Cells; D000956:Antigens, Viral / Q000008:administration & dosage; D001402:B-Lymphocytes / Q000276:immunology; D003090:Coliphages / Q000276:immunology*; D004267:DNA Viruses; D007109:Immunity; D007156:Immunologic Memory; D007165:Immunosuppression Therapy; D007274:Injections, Intraperitoneal; D051379:Mice; D010567:Pertussis Vaccine / Q000008:administration & dosage; D013601:T-Lymphocytes / Q000276:immunology
D000276:Adjuvants, Immunologic; D000956:Antigens, Viral; D010567:Pertussis Vaccine