Detection of a leukocytic endogenous mediator-like mediator of serum amino acid and zinc depression during various infectious illnesses.
Serum samples from patients with many different kinds of infection were shown to contain a substance characteristic of leukocytic endogenous mediator. Generalized bacterial infections produced more leukocytic endogenous mediator than did localized ones; viral infections produced very little. In typhoid fever, mediator concentrations increased before the onset of illness.
D000038:Abscess / Q000276:immunology; D000818:Animals; D001424:Bacterial Infections / Q000276:immunology*; D002250:Carbon Radioisotopes; D002264:Carboxylic Acids / Q000378:metabolism; D003517:Cyclopentanes / Q000378:metabolism; D003967:Diarrhea / Q000276:immunology; D006801:Humans; D007930:Leucine / Q000032:analysis / Q000378:metabolism; D007962:Leukocytes / Q000276:immunology*; D008099:Liver / Q000032:analysis; D051381:Rats; D012763:Shigella flexneri / Q000276:immunology; D013210:Staphylococcus / Q000276:immunology; D014435:Typhoid Fever / Q000276:immunology; D014777:Virus Diseases / Q000276:immunology; D015032:Zinc / Q000097:blood*
D002250:Carbon Radioisotopes; D002264:Carboxylic Acids; D003517:Cyclopentanes; D007930:Leucine; D015032:Zinc