Mineralocorticoid like effect of new 18-hydroxy-steroid isolated from urine of hypertensive patients.
The affinity of new urinary 18-hydroxy-steroid (Cp x) for mineralocorticoid receptors was estimated. When rat kidney slices were incubated with 2 x 10(-9) M 3H-aldosterone, Cp x (2 x 10(-5) M) was able to compete with aldosterone for the mineralocorticoid cytosol receptors. Cp x had low but significant affinity for mineralocorticoid receptor sites. This affinity was less than that obtained with 18-OH-progesterone. Moreover, in the adrenalectomized rats, the injection of Cp x induced a decrease of urinary Na+/K+ ratio which seems comparable to that obtained with 18-OH-progesterone.
D015070:18-Hydroxydesoxycorticosterone / Q000378:metabolism; D000315:Adrenalectomy; D000450:Aldosterone / Q000378:metabolism; D000818:Animals; D006900:Hydroxylation; D006908:Hydroxyprogesterones / Q000378:metabolism; D006914:Hydroxysteroids / Q000652:urine*; D006973:Hypertension / Q000652:urine*; D007668:Kidney / Q000378:metabolism; D008297:Male; D008901:Mineralocorticoids; D051381:Rats; D011955:Receptors, Drug; D013256:Steroids / Q000378:metabolism
D015070:18-Hydroxydesoxycorticosterone; D006908:Hydroxyprogesterones; D006914:Hydroxysteroids; D008901:Mineralocorticoids; D011955:Receptors, Drug; D013256:Steroids; D000450:Aldosterone