Effect of local injection of Corynebacterium parvum on the growth of a murine fibrosarcoma.
Local injection (i.e. injection at the site of tumour inoculation) of strains of C. Parvum which have a significant anti-tumour effect when given systemically (i.e. intravenously or, in the case of subcutaneous tumour transplant, intraperitoneally) strongly inhibits the growth of isogeneic transplants of a fibrosarcoma in intact CBA mice but has little or no effect on subcutaneous transplants of the same tumour in T-cell deprived mice. The anti-tumour effect of local injection of C. parvum, unlike that of systemic injection in this particular tumour system, thus appears to be T-cell dependent.
D000818:Animals; D005260:Female; D005354:Fibrosarcoma / Q000628:therapy*; D007167:Immunotherapy; D007274:Injections, Intraperitoneal; D007275:Injections, Intravenous; D007279:Injections, Subcutaneous; D051379:Mice; D008808:Mice, Inbred CBA; D009368:Neoplasm Transplantation; D011425:Propionibacterium acnes / Q000276:immunology*; D012513:Sarcoma, Experimental / Q000628:therapy; D013601:T-Lymphocytes / Q000276:immunology; D013934:Thymectomy; D014184:Transplantation, Homologous