title: Origin of the TEM-beta-lactamase gene found on plasmids.
abstract: A sequence of deoxyribonucleic acid of 2.7 times 10-6 to 3.3 times 10-6 daltons which includes the TEM beta-lactamase gene is present on the small plasmid RSF 1030 (R-Amp). This same sequence is present on plasmid derivatives that have received a translocation of deoxyribonucleic acid specifying the TEM beta-lactamase and is also present on naturally occurring plasmids of the F1, F11, N, X, O, I, C, and W incompatibility groups that do not specify ampicillin resistance or specify O-type beta-lactamases.
mesh_terms: D000667:Ampicillin / Q000494:pharmacology; D001483:Base Sequence; D002499:Centrifugation, Density Gradient; D004269:DNA, Bacterial / Q000032:analysis; D004926:Escherichia coli / Q000187:drug effects / Q000201:enzymology*; D005111:Extrachromosomal Inheritance; D005796:Genes; D008854:Microscopy, Electron; D008970:Molecular Weight; D009693:Nucleic Acid Hybridization; D010400:Penicillin G / Q000494:pharmacology; D010403:Penicillin Resistance; D010405:Penicillinase / Q000096:biosynthesis*; D013941:Thymine
chemical_list: D004269:DNA, Bacterial; D000667:Ampicillin; D010405:Penicillinase; D010400:Penicillin G; D013941:Thymine