Morphological, immunological and immunocytochemical identification of lymphocytes extracted from cutaneous infiltrates.
The identification of mononuclear cells extracted from various skin disorders has been investigated and the relative amount of B and T cells determined according to various assays such as E-rosette test, FITC and peroxidase anti-immunoglobulin conjugates. It has been found that: (a) there were two different patterns of distribution of the cells in the infiltrates; one with a T/B ratio above 3 (closest to a delayed type reaction), the other with a T/B ratio below 2. (b) The morphological appearance of tissue lymphocytes differs from that of circulating lymphocytes by the presence of both membrane and cytoplasmic immunoglobulins.
D001402:B-Lymphocytes / Q000276:immunology / Q000648:ultrastructure; D002462:Cell Membrane / Q000276:immunology; D006801:Humans; D006968:Hypersensitivity, Delayed / Q000473:pathology; D007104:Immune Adherence Reaction; D007958:Leukocyte Count; D008214:Lymphocytes / Q000276:immunology / Q000648:ultrastructure; D008854:Microscopy, Electron; D011947:Receptors, Antigen, B-Cell; D012867:Skin / Q000166:cytology / Q000473:pathology; D012871:Skin Diseases / Q000473:pathology*; D012878:Skin Neoplasms / Q000473:pathology; D013601:T-Lymphocytes / Q000276:immunology / Q000648:ultrastructure
D011947:Receptors, Antigen, B-Cell