[Phalloidin antagonists. 2. Protective effect of disilybine in phalloidin poisoning of isolated hepatocytes].
Phalloidin produces marked protrusions on the surface of isolated hepatocytes prepared from rat livers. This typical in-vitro effect of the mushroom toxin is prevented or inhibited by preincubation with disilybin. The antagonistic effect depends on the concentration of disilybin and might be caused by an inhibition of phalloidin binding.
D000818:Animals; D056486:Chemical and Drug Induced Liver Injury / Q000188:drug therapy*; D005419:Flavonoids / Q000627:therapeutic use*; D008099:Liver / Q000473:pathology / Q000648:ultrastructure; D008855:Microscopy, Electron, Scanning; D008858:Microscopy, Phase-Contrast; D009842:Oligopeptides / Q000037:antagonists & inhibitors*; D010477:Perfusion; D010590:Phalloidine / Q000037:antagonists & inhibitors*; D011485:Protein Binding; D051381:Rats; D012838:Silymarin / Q000627:therapeutic use*
D005419:Flavonoids; D009842:Oligopeptides; D012838:Silymarin; D010590:Phalloidine
Phalloidin-Antagonisten. 2. Mitteilung: Protektive Wirkung von Disilybin bei der Vergiftung isolierter Hepatozyten mit Phalloidin.