[Effect of anti-inflammatory preparations on the process of thermogenesis in blood erythrocytes].
The authors studied the influence of the main antiphlogistic agents (prednisolone, acetylsalicylic acid, rheopyrine, chloroquine and indomethacine) on the thermal effect of the peripheral blood erythrocytes in man. It was found that only chloroquine possessed a significant inhibitory effect. This fact pointed to the inhibition by chloroquine of energy production in the process of glycolysis, which could be regarded as one of the factors of the therapeutic action of this preparation.
D000632:Aminopyrine / Q000494:pharmacology; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology*; D001241:Aspirin / Q000494:pharmacology; D002738:Chloroquine / Q000494:pharmacology*; D003864:Depression, Chemical; D004734:Energy Metabolism / Q000187:drug effects*; D004912:Erythrocytes / Q000187:drug effects / Q000378:metabolism*; D006019:Glycolysis / Q000187:drug effects; D006801:Humans; D007213:Indomethacin / Q000494:pharmacology; D010653:Phenylbutazone / Q000494:pharmacology; D011239:Prednisolone / Q000494:pharmacology*
D000894:Anti-Inflammatory Agents, Non-Steroidal; D000632:Aminopyrine; D002738:Chloroquine; D011239:Prednisolone; D010653:Phenylbutazone; D001241:Aspirin; D007213:Indomethacin
Vliianie protivovospalitel'nykh preparatov na protsess termogeneza v éritrotsitakh krovi