title: Relation of lymphoid system and hormones to aging.
abstract: Congenital deficiencies of developmental hormones, such as growth hormone and thyroxine, are responsible for the thymus-dependent immunodeficiency disease observed in dwarf mice. Such an immunodeficiency state is associated with early aging phenomena. This fact suggests that lymphoid cells and primarily T-derived cells are involved in the control of aging processes.
mesh_terms: D000311:Adrenal Glands / Q000002:abnormalities; D000375:Aging; D000818:Animals; D000917:Antibody Formation; D001402:B-Lymphocytes / Q000502:physiology; D002454:Cell Differentiation; D004392:Dwarfism / Q000235:genetics; D004912:Erythrocytes / Q000276:immunology; D006066:Gonads / Q000002:abnormalities; D006084:Graft Rejection; D013006:Growth Hormone / Q000172:deficiency; D006706:Homeostasis; D007111:Immunity, Cellular; D007455:Iodine / Q000378:metabolism; D007457:Iodine Radioisotopes; D007958:Leukocyte Count; D008198:Lymph Nodes / Q000002:abnormalities; D008214:Lymphocytes; D008221:Lymphoid Tissue; D051379:Mice; D009154:Mutation; D010902:Pituitary Gland / Q000002:abnormalities; D016038:Skin Transplantation; D013154:Spleen / Q000002:abnormalities; D013601:T-Lymphocytes / Q000502:physiology; D013961:Thyroid Gland / Q000002:abnormalities; D013972:Thyrotropin / Q000172:deficiency; D014184:Transplantation, Homologous
chemical_list: D007457:Iodine Radioisotopes; D013972:Thyrotropin; D013006:Growth Hormone; D007455:Iodine