[Action of different components of the kallikrein kinin-system on sperm motility in vitro (author's transl)].
In vitro experiments with human semen showed a significant increase of quantitative and qualitative sperm motility after addition of kallikrein at concentrations of 1 KU/ml. Stimulation of sperm motility was further increased and extended by addition of human serum as a source of kininogen. Kinins added directly also showed enhancement of sperm motility. In contrast, carboxypeptidase B, a kininase, significantly reduced sperm motility. The physiological and therapeutical aspects of these results are discussed.
D007611:Aprotinin / Q000494:pharmacology; D001769:Blood; D002268:Carboxypeptidases / Q000494:pharmacology; D002465:Cell Movement / Q000187:drug effects; D006801:Humans; D066298:In Vitro Techniques; D007610:Kallikreins / Q000494:pharmacology*; D007704:Kininogens / Q000494:pharmacology; D007705:Kinins / Q000494:pharmacology*; D008297:Male; D013078:Sperm Immobilizing Agents / Q000494:pharmacology; D013094:Spermatozoa / Q000187:drug effects*
D007704:Kininogens; D007705:Kinins; D013078:Sperm Immobilizing Agents; D007611:Aprotinin; D002268:Carboxypeptidases; D007610:Kallikreins
Wirkungen von verschiedenen Komponenten des Kallikrein-Kinin-Systems auf die Spermatozoen-Motilität in vitro