In vitro inhibition of endotoxin induced platelet aggregation with hydrocortisone sodium succinate (Solu-Cortef).
Citrated canine platelet rich plasma stimulated with ADP, thrombin, collagen and E. coli endotoxin demonstrated platelet aggregation when measured with Payton aggregometer. Following incubation with hydrocortisone sodium succinate (Solu-Cortef) the same platelet rich plasma did not undergo platelet aggregation when stimulated by these agents. Solu-Cortef added to platelet rich plasma during ATP, thrombin, collagen and endotoxin stimulated platelet aggregation resulted in a reversal of the optical density suggesting deaggregation. These in vitro observations support the beneficial effects observed when steroids are administered in vivo to experimental or clinical shock.
D000244:Adenosine Diphosphate / Q000494:pharmacology; D000818:Animals; D003094:Collagen / Q000494:pharmacology; D004285:Dogs; D004347:Drug Interactions; D004731:Endotoxins / Q000494:pharmacology; D004926:Escherichia coli; D006854:Hydrocortisone / Q000494:pharmacology*; D010974:Platelet Aggregation / Q000187:drug effects*; D013386:Succinates / Q000494:pharmacology; D013917:Thrombin / Q000494:pharmacology
D004731:Endotoxins; D013386:Succinates; D000244:Adenosine Diphosphate; D003094:Collagen; D013917:Thrombin; D006854:Hydrocortisone