Studies on the influence of leucomycine on the carbohydrate metabolism of the lens in vitro.
The influence of leucomycine (10(-5) M--5 X 10(-3) M) on enzyme activities, free adenine nucleotides, and some intermediates of glycolysis in bovine lenses has been investigated. After a 48 h incubation in TCM 199, 6 out of 9 enzymes activities tested were decreased. Concentrations of energy rich nucleotifes, glucose, fructose, and fructose-6-phosphate as well as those of fructose-1,6-diphosphate and lactate were also decreased, whereas adenine monophosphate was increased.
D000249:Adenosine Monophosphate / Q000032:analysis; D000818:Animals; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D002417:Cattle; D005636:Fructosephosphates / Q000032:analysis; D005947:Glucose / Q000032:analysis; D007773:Lactates / Q000032:analysis; D007908:Lens, Crystalline / Q000032:analysis / Q000187:drug effects* / Q000201:enzymology / Q000378:metabolism; D007933:Leucomycins / Q000494:pharmacology*; D013997:Time Factors
D000900:Anti-Bacterial Agents; D005636:Fructosephosphates; D007773:Lactates; D007933:Leucomycins; D000249:Adenosine Monophosphate; D005947:Glucose