Lowering of the tumoricide activity of human serum with Varidase. II. Antibodies against Varidase in human serum measured by complement binding.
Active human serum manifests a tumoricide effect against cells of the Ehrlich ascites tumor. Sera of patients with Ca ventriculi show a higher effect than those of patients with a chronic streptococcal disorder, in comparison with intact subjects. This tumorcide effect is depressed by Varidase, the degree of depression being greatest in the group of patients with streptococcal infection, smaller in healthy subjects and least in carcinoma patients. The investigated sera contained antibodies against Varidase, but not against streptokinase. The anti-Varidase antibodies are found also in sera of the new-born children. The decline of the tumoricide activity of Varidase-treated sera is related to the quantity of anti-Varidase antibodies determined by complement fixing reaction in non-treated sera.
D000230:Adenocarcinoma / Q000201:enzymology; D000818:Animals; D000906:Antibodies / Q000032:analysis; D000907:Antibodies, Bacterial / Q000032:analysis; D002286:Carcinoma, Ehrlich Tumor / Q000276:immunology; D003168:Complement Fixation Tests; D003851:Deoxyribonucleases / Q000378:metabolism; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D051379:Mice; D008809:Mice, Inbred C3H; D009132:Muscles / Q000201:enzymology; D009369:Neoplasms / Q000276:immunology*; D009374:Neoplasms, Experimental / Q000201:enzymology / Q000276:immunology; D011247:Pregnancy; D013154:Spleen / Q000201:enzymology; D013290:Streptococcal Infections / Q000276:immunology; D013297:Streptococcus pyogenes; D013299:Streptodornase and Streptokinase / Q000494:pharmacology*
D000906:Antibodies; D000907:Antibodies, Bacterial; D013299:Streptodornase and Streptokinase; D003851:Deoxyribonucleases