Anaemia and the induction of myeloid leukaemia in RFM mice.
The results from short term experiments provide little support for the idea that the anaemic stress produced by phlebotomy acts as a trigger for myeloid leukaemia in mice genetically prone to the development of the disease. Longer term investigation has also failed to reveal any difference between bled and control mice and at this time (16 months after bleeding) no animals have died from myeloid leukaemia. These observations are in contrast to the recently reported effect of phlebotomy as a trigger for myeloid leukaemia in unirradiated RFM mice and in irradiated rats. The results given in this paper are discussed in relation to the haemopoietic stem cell compartment in leukaemogenesis and the relationship between these cells and the mature cells in the peripheral blood.
D000740:Anemia / Q000150:complications* / Q000209:etiology; D000818:Animals; D001815:Bloodletting; D001853:Bone Marrow / Q000276:immunology; D001854:Bone Marrow Cells; D002999:Clone Cells; D003115:Colony-Stimulating Factors; D004906:Erythrocyte Count; D005260:Female; D006400:Hematocrit; D007942:Leukemia, Experimental / Q000209:etiology*; D007951:Leukemia, Myeloid / Q000209:etiology*; D007958:Leukocyte Count; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D013154:Spleen / Q000276:immunology
D003115:Colony-Stimulating Factors