The effect of lysozyme on the complement-dependent bactericidal action of different antibody classes.
Preparations of rabbit, dog and sheep IgA, IgA and IgM were examined for their antibacterial effects using a complement-dependent bactericidal assay. IgM and IgG were efficient bactericidal antibodies in the presence of complement; IgA, however, contained negligible activity. Except for sheep IgG no enhancement of bactericidal activity was observed in the presence of added lysozyme.
D000818:Animals; D001770:Blood Bactericidal Activity / Q000187:drug effects; D003165:Complement System Proteins; D004285:Dogs / Q000276:immunology; D004926:Escherichia coli / Q000276:immunology; D007070:Immunoglobulin A; D007074:Immunoglobulin G; D007075:Immunoglobulin M; D007136:Immunoglobulins; D009113:Muramidase / Q000494:pharmacology*; D011817:Rabbits / Q000276:immunology; D012756:Sheep / Q000276:immunology; D014734:Vibrio cholerae / Q000276:immunology
D007070:Immunoglobulin A; D007074:Immunoglobulin G; D007075:Immunoglobulin M; D007136:Immunoglobulins; D003165:Complement System Proteins; D009113:Muramidase