title: Current status of the treatment of syphilis.
abstract: Penicillin remains the treatment of choice for syphilis, with sustained low blood levels curing virtually all patients having early syphilis and halting disease progression in most patients with symptomatic syphilis. Tetracycline, erythromycin or cephalothin yields similar cure rates for patients with early syphilis who are allergic to penicillin. The efficacy of non-penicillin regimens for the treatment of late syphilis is uncertain. Results of Venereal Disease Research Laboratory (VDRL) or other reagin tests should become negative or remain at very low titer following adequate therapy, although results of Treponema pallidum immobilization (TPI) and fluorescent treponemal antibody-absorbed (FTA-ABS) tests often remain positive.
mesh_terms: D002506:Cephalexin / Q000627:therapeutic use; D002509:Cephaloridine / Q000627:therapeutic use; D002511:Cephalosporins / Q000627:therapeutic use; D002701:Chloramphenicol / Q000627:therapeutic use; D004342:Drug Hypersensitivity / Q000453:epidemiology / Q000209:etiology; D004917:Erythromycin / Q000627:therapeutic use; D005260:Female; D005334:Fever / Q000139:chemically induced; D005455:Fluorescent Antibody Technique; D005500:Follow-Up Studies; D006801:Humans; D009494:Neurosyphilis / Q000188:drug therapy; D010401:Penicillin G Benzathine / Q000627:therapeutic use; D010406:Penicillins / Q000009:adverse effects / Q000627:therapeutic use*; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000188:drug therapy; D011261:Pregnancy Trimester, First; D013587:Syphilis / Q000134:cerebrospinal fluid / Q000188:drug therapy*; D013588:Syphilis Serodiagnosis; D013589:Syphilis, Cardiovascular / Q000188:drug therapy; D013590:Syphilis, Congenital / Q000188:drug therapy / Q000517:prevention & control; D013592:Syphilis, Latent / Q000188:drug therapy; D013752:Tetracycline / Q000627:therapeutic use; D014210:Treponema pallidum / Q000276:immunology; D014481:United States
chemical_list: D002511:Cephalosporins; D010406:Penicillins; D004917:Erythromycin; D002701:Chloramphenicol; D013752:Tetracycline; D002509:Cephaloridine; D002506:Cephalexin; D010401:Penicillin G Benzathine