title: The natural history of non-Hodgkin's lymphomata stages I and II.
abstract: Progress in the management of non-Hodgkin's lymphomata has been impeded by lack of information on the natural history of these diseases. Confusion about the significance of histopathology, extranodal presentations and routes of spread renders much of previously published data relatively uninterpretable. To evaluate the relative prognostic significance of presentation, histopathology and lymphography, a retrospective study was undertaken on 226 patients with Stage I and II disease, who were treated with intensive irradiation to the involve regions. The slides on these patients were reviewed and reclassified in terms of the Rappaport system. The results of this study demonstrated that a nodular histopathological pattern was the most important prognostic factor. The significance of this finding and other factors are discussed in terms of possible new approaches to treatment.
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D001011:Aorta; D002648:Child; D002675:Child, Preschool; D002968:Clavicle; D003037:Cobalt Radioisotopes / Q000627:therapeutic use; D005260:Female; D006258:Head and Neck Neoplasms / Q000473:pathology; D006801:Humans; D008198:Lymph Nodes; D008220:Lymphography; D008223:Lymphoma / Q000000981:diagnostic imaging / Q000473:pathology* / Q000532:radiotherapy; D016403:Lymphoma, Large B-Cell, Diffuse / Q000473:pathology; D008228:Lymphoma, Non-Hodgkin / Q000473:pathology; D008297:Male; D008482:Mediastinum; D008875:Middle Aged; D012189:Retrospective Studies; D013274:Stomach Neoplasms / Q000473:pathology; D013964:Thyroid Neoplasms / Q000473:pathology
chemical_list: D003037:Cobalt Radioisotopes