Experimental endogenous endophthalmitis caused by Haemophilus influenzae type b.
Experimental endogenous endophthalmitis was produced in infant rats by either intranasal or intraperitoneal inoculation with Haemophilus influenzae type b and 5 days of age. The ocular disease occurred in about 50% of bacteremic animals who survived to age 12 days and probably represents metastatic bacterial infection secondary to hematogenous seeding. The lesion was a highly destructive suppurative endophthalmitis that ultimately progressed to panophthalmitis and was followed by organization of the exudate and phthisis bulbi.
D000818:Animals; D005128:Eye Diseases / Q000209:etiology*; D006192:Haemophilus Infections; D006193:Haemophilus influenzae / Q000472:pathogenicity*; D007249:Inflammation / Q000473:pathology; D007908:Lens, Crystalline / Q000473:pathology; D010202:Panophthalmitis / Q000473:pathology; D051381:Rats; D014606:Uveitis, Anterior / Q000473:pathology