Effect of a long-acting estrogen on the pituitary response to LH-releasing hormone (38582).
The effect of Quinestrol, an estrogenic substance of long-lasting activity, on the pituitary responsiveness to LH-RH was studied in ovariectomized rats.  Quinestrol administered as a single 200 pg-dose significantly augmented the pituitary response to LH-RH 36 hr, 9 days, and although not significantly, also at 24 days after its oral administration.  No effect could be detected 36 days after its administration.  At a 20 pg-dose Quinestrol significantly augmented the pituitary response to LH-RH only at the 36 hr-period studied, this effect not being apparent in later time periods.
D000818:Animals; D002369:Castration; D004305:Dose-Response Relationship, Drug; D005260:Female; D007987:Gonadotropin-Releasing Hormone / Q000494:pharmacology*; D009651:Norpregnatrienes / Q000494:pharmacology*; D010053:Ovary / Q000502:physiology; D010902:Pituitary Gland / Q000187:drug effects / Q000378:metabolism*; D011800:Quinestrol / Q000008:administration & dosage / Q000494:pharmacology*; D051381:Rats; D013268:Stimulation, Chemical; D013997:Time Factors
D009651:Norpregnatrienes; D007987:Gonadotropin-Releasing Hormone; D011800:Quinestrol