The effect of lithium chloride on morphine- and pyrogen-induced hyperthermia in rats.
In rats, doses of morphine between 2.5 and 20 mg/kg produced hyperthermia, 50-400 mg/kg lithium chloride induced dose-dependent hypothermia. These doses of lithium chloride inhibited morphine- and pyrogen-induced hyperthermia. The hypothermic effect of lithium may be due to the replacement of sodium ions by lithium ions in the hypothalamus. The antagonism between morphine and lithium is nonspecific.
D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal; D004305:Dose-Response Relationship, Drug; D004347:Drug Interactions; D005334:Fever / Q000139:chemically induced / Q000188:drug therapy*; D008094:Lithium / Q000008:administration & dosage / Q000627:therapeutic use*; D008297:Male; D009020:Morphine / Q000008:administration & dosage / Q000037:antagonists & inhibitors*; D011749:Pyrogens / Q000008:administration & dosage; D051381:Rats
D000894:Anti-Inflammatory Agents, Non-Steroidal; D011749:Pyrogens; D009020:Morphine; D008094:Lithium