Cellular recognition and activation within the lymphoid system.
The present study is concerned with cellular recognition and activation within the lymphoid system. Data presented indicate that in human peripheral blood phagocytes recognize and preferentially bind phagocytes, and thymus-derived (T) lymphocytes recognize and preferentially bind other T lymphocytes rather than thymus-indepedent (B) lymphocytes. Recognition of non-self results in activation of lymphoid cells; recent data using a calcium ionophore, A23 187, suggest that calcium may act as an intracellular messenger by which signals for cellular activation are transmitted from the cell surface to the nucleus.
D000818:Animals; D001402:B-Lymphocytes / Q000276:immunology / Q000378:metabolism; D001665:Binding Sites; D001773:Blood Cells / Q000276:immunology*; D002118:Calcium / Q000502:physiology; D002417:Cattle; D002462:Cell Membrane / Q000276:immunology; D004912:Erythrocytes / Q000378:metabolism; D006801:Humans; D007104:Immune Adherence Reaction; D007111:Immunity, Cellular; D008221:Lymphoid Tissue / Q000276:immunology*; D010586:Phagocytes / Q000276:immunology / Q000378:metabolism; D010587:Phagocytosis; D010802:Phylogeny; D012756:Sheep; D013601:T-Lymphocytes / Q000276:immunology / Q000378:metabolism
D002118:Calcium