Control of t-lymphocyte and B-lymphocyte activation by two complementing Ir-GLphi immune response genes.
The possibility that the two complementing alpha- and beta-Ir-GLphi genes are independently responsible for controlling events in T lymphocytes and B lymphocytes, respectively, has been tested in double adoptive transfer experiments utilizing cells from appropriate inbred strains of mice. The results of these studies show that the functions of T lymphocytes and B lymphocytes and the cooperative interactions between T and B cells require the presence of both alpha- and beta-genes in each respective cell type. Moreover, evidence has been obtained in these studies that indicates a preference for the alpha- and beta-Ir-GLphi genes in the cis position to obtain the most effective T-B-cell interactions. The possible implications of these findings are discussed.
D000818:Animals; D000917:Antibody Formation; D000941:Antigens; D005796:Genes; D005816:Genetic Complementation Test; D008040:Genetic Linkage; D005971:Glutamates / Q000276:immunology; D006433:Hemocyanins / Q000276:immunology; D006649:Histocompatibility Antigens; D007156:Immunologic Memory; D008239:Lysine / Q000276:immunology; D051379:Mice; D008815:Mice, Inbred Strains; D009578:Nitrobenzenes / Q000276:immunology; D010455:Peptides / Q000276:immunology*; D010649:Phenylalanine / Q000276:immunology; D013601:T-Lymphocytes / Q000276:immunology*
D000941:Antigens; D005971:Glutamates; D006649:Histocompatibility Antigens; D009578:Nitrobenzenes; D010455:Peptides; D010649:Phenylalanine; D006433:Hemocyanins; D008239:Lysine