Falciparum malaria cured by quinine followed by sulfadoxine-pyrimethamine.
Quinine (at least four doses given at intervals of eight to 12 hours) followed by a single dose of sulfadoxine-pyrimethamine (Fansidar) is the most effective treatment of chloroquine-resistant falciparum malaria. This regimen cured 96% of patients (302 out of 314) with an average initial parasite count of 90 X 10-9/1.
D000284:Administration, Oral; D000328:Adult; D001769:Blood / Q000469:parasitology; D004338:Drug Combinations; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D007275:Injections, Intravenous; D008288:Malaria / Q000188:drug therapy* / Q000209:etiology / Q000469:parasitology; D008297:Male; D010963:Plasmodium falciparum / Q000302:isolation & purification; D011739:Pyrimethamine / Q000627:therapeutic use*; D011803:Quinine / Q000008:administration & dosage / Q000627:therapeutic use*; D013413:Sulfadoxine / Q000627:therapeutic use*; D013424:Sulfanilamides / Q000627:therapeutic use*
D004338:Drug Combinations; D013424:Sulfanilamides; D013413:Sulfadoxine; D011803:Quinine; D011739:Pyrimethamine