[A double blind comparison of naproxen and indomethacin on the after-midnight-pain of patients with morbus bechterew].
27 patients with ascertained ankylosing spondylitis experiencing constant after-midnight-pain received, following three medication-free days, in a double blind, randomized, cross-over fashion indometacin (100 g/day) and d-2-(6'-methoxy-2'-naphthyl)-propionic acid (naproxen) (500 mg/day), as suppositories, for a period of six days each. The intensity of the night-pain was recorded daily. Naproxen was shown to be equally effective as indometacin in alleviating the after-midnight backache of ankylosing spondylitis. Side effects occurred under indometacin in 5 cases, under naproxen in 3 cases.
D000328:Adult; D002986:Clinical Trials as Topic; D005260:Female; D006801:Humans; D007213:Indomethacin / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D009280:Naphthaleneacetic Acids / Q000627:therapeutic use*; D009288:Naproxen / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D010146:Pain / Q000188:drug therapy*; D013167:Spondylitis, Ankylosing / Q000188:drug therapy*; D013488:Suppositories; D013997:Time Factors
D009280:Naphthaleneacetic Acids; D013488:Suppositories; D009288:Naproxen; D007213:Indomethacin
Wirkungsvergleich von Naproxen und Indometacin im Doppelblindversuch beim Nachmitternachtsschmerz von M. Bechterew-Kranken