Cancer in a familial IgA deficiency patient: abnormal chromosomes and B lymphocytes.
Two primary cancers were found in a patient with a familial IgA deficiency. Although cytogenetic studies showed nonconsistent pseudodiploid chromosomal pattern in the peripheral blood lymphocyte cultures, there were two metaphases with a deleted short arm of an E (17-18) chromosome and several metaphases with an abnormally large chromosome, larger than chromosome number 1. Also, there were 37 B lymphocytes per mm3 in her peripheral blood which was much lower than other radiation-treated cancer patients. The absence of IgA, the decrease of peripheral B lymphocytes and the chromosomal abnormality might have played a role in her developing the cancers.
D000230:Adenocarcinoma / Q000150:complications*; D001402:B-Lymphocytes; D002869:Chromosome Aberrations; D004406:Dysgammaglobulinemia / Q000097:blood / Q000150:complications* / Q000235:genetics; D005260:Female; D006801:Humans; D007070:Immunoglobulin A; D007153:Immunologic Deficiency Syndromes / Q000150:complications*; D007621:Karyotyping; D007958:Leukocyte Count; D008175:Lung Neoplasms / Q000150:complications; D008875:Middle Aged; D012004:Rectal Neoplasms / Q000150:complications*
D007070:Immunoglobulin A