Radioprotection of lipogenesis from glucose (U-14C) and activities of pyridine nucleotide dehydrogenases in liver of gamma-irradiated female rats by cystamine.
Whole-body gamma-irradiation (1200 R) of female rats significantly increased liver glycogen and incorporation of glucose (U-14C) into liver fatty acids. Administration of cystamine before irradiation protected the enhanced lipogenesis from glucose (U-14C), but afforded only a partial protection of liver glycogen levels. Irradiation significantly decreased the activities of liver pyruvate kinase and isocitrate dehydrogenase, and this decrease was not prevented by the administration of cystamine before irradiation. A significant increase in the activity of liver malate dehydrogenase (dehydrogenating) was noted in irradiated rats, which was not prevented by the administration of cystamine before irradiation. Irradiation did not affect the activities of combined hexose monophosphate pathway dehydrogenases and of malate dehydrogenase (decarboxylating).
D000818:Animals; D003538:Cystamine / Q000494:pharmacology*; D005227:Fatty Acids / Q000378:metabolism; D005260:Female; D005720:Gamma Rays; D005947:Glucose / Q000378:metabolism; D005954:Glucosephosphate Dehydrogenase / Q000378:metabolism; D007521:Isocitrate Dehydrogenase / Q000378:metabolism; D008099:Liver / Q000201:enzymology / Q000378:metabolism* / Q000528:radiation effects; D008112:Liver Glycogen / Q000378:metabolism; D008291:Malate Dehydrogenase / Q000378:metabolism; D010734:Phosphogluconate Dehydrogenase / Q000378:metabolism; D011830:Radiation Effects; D011837:Radiation-Protective Agents / Q000494:pharmacology*; D051381:Rats
D005227:Fatty Acids; D008112:Liver Glycogen; D011837:Radiation-Protective Agents; D008291:Malate Dehydrogenase; D007521:Isocitrate Dehydrogenase; D010734:Phosphogluconate Dehydrogenase; D005954:Glucosephosphate Dehydrogenase; D005947:Glucose; D003538:Cystamine