Marked prolongation of skin homograft survival with niridazole. A first report.
Niridazole, a nitroheterocyclic drug used to treat helminth infections is reported for the first time to suppress cell-mediated immunity, as ascertained by multiple in vivo assays. Skin homograft survival time was significantly prolonged in mice, without loss of animals due to drug toxicity.
D000818:Animals; D000961:Antilymphocyte Serum / Q000494:pharmacology; D006084:Graft Rejection / Q000517:prevention & control*; D007165:Immunosuppression Therapy; D007958:Leukocyte Count; D051379:Mice; D008815:Mice, Inbred Strains; D009560:Niridazole / Q000494:pharmacology*; D016038:Skin Transplantation; D013154:Spleen / Q000166:cytology; D013601:T-Lymphocytes / Q000276:immunology; D014184:Transplantation, Homologous
D000961:Antilymphocyte Serum; D009560:Niridazole