Age-related changes of cells involved in immune responses.
The interaction between T- and B-lymphocytes in the immune response to sheep reythrocytes was revealed by estimating the direct plaque-forming cells in mice CMA of various age. Investigations with a transfer of cells to irradiated and intact recipients were performed. We found a 23-fold diminution of the immune response in mice aged 26-28 months, when compared with that in mice aged 8 months. The first signs of a disturbed activity of the immune system were found in animals whose age did not exceed the half of their average lifespan. The injection of B-lymphocytes from young animals does not give rise to the immune response of old nonirradiated recipients. The injection of young b-lymphocytes to old irradiated recipients, being primed by antigen using Playfair's technique before irradiation, results in the highest response than it is in other combinations. The effect of disturbances in the interaction between  T- and B-cells on the mechanism of age-related changes of the immune response is discussed.
D000375:Aging; D000818:Animals; D000921:Antibody-Producing Cells; D000941:Antigens; D001402:B-Lymphocytes / Q000276:immunology / Q000637:transplantation; D002455:Cell Division; D002999:Clone Cells; D004912:Erythrocytes / Q000276:immunology; D006462:Hemolytic Plaque Technique; D007109:Immunity; D051379:Mice; D008808:Mice, Inbred CBA; D011830:Radiation Effects; D012756:Sheep / Q000276:immunology; D013154:Spleen / Q000276:immunology; D013601:T-Lymphocytes / Q000276:immunology; D014184:Transplantation, Homologous
D000941:Antigens