Quinoxaline studies. 23. Potential antimalarials. Substituted 5,8-dimethoxyquinoxalines.
Two series of 2,3-disubstituted 5,8-dimethoxy-6-[N- (omega-dimethylaminoalkyl) amino] quinoxalines were prepared: the first series with identical 2,3-substituents H, CH3, C6H5, C6H4-4-Cl, and CH2C6H5; and the second with identical styryl groups CH=CHC6H5, CH=CHC6H4-4-Cl, CH=CHC6H3-3,4-C12, CH=CHC6H4-4-F, CH=CHC6H4-4-CF3, and CH=CHC6H4-4-NO2. None of the substances possessed antimalarial activity; several were toxic at highest dosage levels.
D000818:Animals; D000962:Antimalarials / Q000138:chemical synthesis*; D002645:Chickens; D008288:Malaria / Q000188:drug therapy; D008289:Malaria, Avian / Q000188:drug therapy; D051379:Mice; D010962:Plasmodium berghei; D011810:Quinoxalines / Q000138:chemical synthesis* / Q000627:therapeutic use; D013056:Spectrophotometry, Ultraviolet
D000962:Antimalarials; D011810:Quinoxalines