Immunologic characterization of cerebrospinal fluid lymphocytes: preliminary report.
Cellular immunocompetence of cerebrospinal fluid lymphocytes was investigated in several neurologic diseases. Microtechniques were developed to enable determination of E-rosetting capacity and phytohemagglutinin responsiveness of scant numbers of cells present in the cerebrospinal fluid specimens studied. Although most individuals had phytohemagglutinin-responsive cells in their CSF, reactivity was somewhat less than that found simultaneously in their blood. Three of eight patients had comparable percentages of E rosettes in their blood and CSF. Int the remainder, the values differed significantly. Although preliminary, these result illustrate a new approach to immunologic characterization of CSF lymphocytes in diseases.
D001922:Brain Abscess / Q000134:cerebrospinal fluid / Q000276:immunology; D002555:Cerebrospinal Fluid / Q000166:cytology*; D004660:Encephalitis / Q000134:cerebrospinal fluid / Q000276:immunology; D006406:Hematoma / Q000134:cerebrospinal fluid / Q000276:immunology; D006801:Humans; D007111:Immunity, Cellular; D008214:Lymphocytes / Q000276:immunology*; D008581:Meningitis / Q000134:cerebrospinal fluid / Q000276:immunology; D008722:Methods; D009103:Multiple Sclerosis / Q000134:cerebrospinal fluid / Q000276:immunology; D013601:T-Lymphocytes / Q000276:immunology