[The effect of tryptophan, 5-hydroxytryptophan, serotonin, histidine and histamine on the peroxidation of lipids in hepatic mitochondrial membranes].
The method of recording the superweak chemifluorescence was applied to the study of the effect of tryptophan, 5-oxytryptophan, sertonin, histidine and histamine on the peroxication of lipids in the membranes of mitochondria of rat liver in the presence of Fe++ ions inducing this process. 5-oxytryptophan and serotonin inhibited this process in a concentration of 10(-5)-10(-4) M (protein content -1.8 mg per 1 ml of mitochondrial suspension). On the basis of studying the kinetics of the initial portion of the ascending branch of the "slow flare up" constants of the antioxidatinve activity (constituting 2.2-10(3) and 9.8-10(3) M-1 for 5-oxytryptophan and serotonin, respectively) was calculated. The antioxidative action is associated with the presence of the phenol group in the molecule of the compound under study. It is supposed that the action of 5-oxytryptophan and serotonin on peroxidation of lipids in the membranes was of significance for the regulation of permeability of the biological membranes, along with their effect on the other membrane processes.
D006916:5-Hydroxytryptophan / Q000494:pharmacology; D000818:Animals; D006632:Histamine / Q000494:pharmacology; D006639:Histidine / Q000494:pharmacology; D006651:Histocytochemistry; D050356:Lipid Metabolism; D008566:Membranes / Q000378:metabolism; D008930:Mitochondria, Liver / Q000187:drug effects* / Q000378:metabolism; D051381:Rats; D012701:Serotonin / Q000494:pharmacology; D014364:Tryptophan / Q000494:pharmacology
D012701:Serotonin; D006639:Histidine; D006632:Histamine; D014364:Tryptophan; D006916:5-Hydroxytryptophan
Vliianie triptofana, 5-oksitriptofana, serotonina, gistidina i gistamina na perekisnoe okislenie lipidov v membranakh mitokhondriĭ pecheni