[Histiocytosis X. Histochemical study of intracytoplasmic lipids. Apropos of 3 cases].
Histochemical study combined with differential extractions of lipids from biopsy fragments in three cases of eosinophil granuloma reveals a great amount and variety of lipidic categories existing in histiocytosis X cells : sterids, fatty-acids, triacylglycerols, phosphoglycerids, cholino-phospholipids, sphingomyelins, glycolipids. Comparison of the lipidic content of histiocytosis X cells and that of normal histiocytes, showed a preponderance of cholesterol esters in histiocytosis X contrary to the normal macrophages and alteration in phospholipidic control of cholesterol esterification. This study confirms that the histiocytosis X cells have an active and probably preferential lipid metabolism, explaining the frequent xanthomatous changes of the lesions and the intense production of various cytoplasmic membranous structures.
D001847:Bone Diseases / Q000378:metabolism*; D002675:Child, Preschool; D002784:Cholesterol / Q000378:metabolism; D003593:Cytoplasm / Q000378:metabolism; D004803:Eosinophilic Granuloma / Q000378:metabolism*; D005230:Fatty Acids, Nonesterified / Q000378:metabolism; D005231:Fatty Acids, Unsaturated / Q000378:metabolism; D006017:Glycolipids / Q000378:metabolism; D006644:Histiocytes / Q000378:metabolism*; D006801:Humans; D050356:Lipid Metabolism; D008297:Male; D010713:Phosphatidylcholines / Q000378:metabolism; D010714:Phosphatidylethanolamines / Q000378:metabolism; D010743:Phospholipids / Q000378:metabolism; D014280:Triglycerides / Q000378:metabolism
D005230:Fatty Acids, Nonesterified; D005231:Fatty Acids, Unsaturated; D006017:Glycolipids; D010713:Phosphatidylcholines; D010714:Phosphatidylethanolamines; D010743:Phospholipids; D014280:Triglycerides; D002784:Cholesterol
Histiocytose X.. Etude histochimique des lipides intracytoplasmiques. A propos de 3 observations