Response to pentagastrin in man. III. Comparison of two formulations.
Gastric secretion has been studied in response to the standard preparation of pentagastrin and a new, more stable preparation (pentagastrin meglumine). The sensitivity to, and maximal outputs of acid and pepsin elicited by, the two preparations of pentagastrin did not differ. However, the pentagastrin meglumine evoked a better sustained acid secretion with all dose rates than did the standard pentagastrin.
D000606:Amino Sugars / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D005750:Gastric Juice / Q000187:drug effects* / Q000378:metabolism; D006801:Humans; D010418:Pentagastrin / Q000031:analogs & derivatives* / Q000494:pharmacology*; D010434:Pepsin A / Q000378:metabolism*; D013012:Sorbitol / Q000031:analogs & derivatives / Q000494:pharmacology; D013997:Time Factors
D000606:Amino Sugars; D013012:Sorbitol; D010434:Pepsin A; D010418:Pentagastrin