title: [Chromosome studies on human fibroblast cultures following exposure to cyproheptadin].
abstract: Cyproheptadin was tested on chromosomes in fibroblast cultures of children for its possible mutagenic efficacy. Neither 24-hour exposure to Cyproheptadin at concentrations of 8-16 mg/l medium nor a chronic exposure for 8-11 weeks at a concentration of 8 mg/l caused any discernable chromosomal mutations. At concentrations between 8-16 mg/l reversible cytomorphological and cytochemical changes occured; 32 mg/l suppressed cell division and higher concentrations (64-128 mg/l) brought about irreversible changes leading to cell death. These reactions were rather in vitro cytotoxic effects of unspecific nature.
mesh_terms: D002455:Cell Division; D002478:Cells, Cultured; D002648:Child; D002675:Child, Preschool; D002869:Chromosome Aberrations; D002874:Chromosome Mapping; D002875:Chromosomes / Q000187:drug effects*; D003470:Culture Media; D003533:Cyproheptadine / Q000494:pharmacology*; D003584:Cytological Techniques; D005260:Female; D005347:Fibroblasts / Q000187:drug effects*; D006801:Humans; D066298:In Vitro Techniques; D007223:Infant; D008297:Male; D008854:Microscopy, Electron; D008938:Mitosis; D013997:Time Factors
chemical_list: D003470:Culture Media; D003533:Cyproheptadine
vernacular_title: Chromosomenuntersuchungen an menschlichen Fibroblastenkulturen nach Zugabe von Cyproheptadin