[Effect of orotic acid on the in vitro cultured nerve tissue].
Cell- and explantcultures of the hippocampus of 18 days old fetal rats and explantcultures of the ganglion trigeminal of 9 days old chick embryos were cultivated in Maximow-chambers. Orotic acid, Sodiumorotate and methylglucaminorotate by concentrations of 10(-3)...10(-7) g/ml medium were added to the cultures. By concentrations of 10(-7) g/ml medium in the CNS-cultures and 10(-6) g/ml medium in the PNS-cultures is stimulated the nerve fiber growth and is increased the nerve fiber index. After three weeks in vitro is a higher number of neurons in the cultures compared to the controls.
D000818:Animals; D002454:Cell Differentiation / Q000187:drug effects; D002455:Cell Division / Q000187:drug effects; D002470:Cell Survival / Q000187:drug effects; D002642:Chick Embryo; D003470:Culture Media; D046508:Culture Techniques; D006624:Hippocampus / Q000196:embryology; D009474:Neurons / Q000166:cytology / Q000187:drug effects*; D009963:Orotic Acid / Q000494:pharmacology*; D051381:Rats; D012668:Trigeminal Ganglion; D014529:Uridine / Q000494:pharmacology
D003470:Culture Media; D009963:Orotic Acid; D014529:Uridine
Uber die Wirkung von Orotsäure auf in vitro kultiviertes Nervengewebe.