[Demonstration of gastrointestinal hemorrhages in the acute radiation syndrome].
Increased radioiron excretion with feces following irradiation is a sure indicator of thrombopenia-induced gastrointestinal hemorrhages which are to be regarded as one of the main causes of the acute radiation syndrome or radiation death respectively. We analyzed the daily 59Fe- excretion of whole-body irradiated mice from the 7th to the 16th day after radiation insult, this period being the critical phase in the course of acute radiopathy with a mortality amounting here to about 50% of the irradiated animals (bone-marrow syndrome). On the eleventh day after radiation exposure, 59Fe-excretion of irradiated animals significantly exceeded by more than fivefold that of the controls. If, before radiation exposure, the mice have been treated with the protective agent AET, they survived without exception and, moreover, a significantly reduced 59Fe-excretion was noted too, the control values almost being reached again. By means of the radionuclide 59Fe therefore, ont only statements are possible concerning the functional state of the erythropoietic system, but also troubles of the hemostatic system can be detected, e.g. the pathological transition of blood into the gastrointestinal tract.
D000818:Animals; D005243:Feces / Q000032:analysis; D006471:Gastrointestinal Hemorrhage / Q000175:diagnosis* / Q000209:etiology; D007504:Iron Radioisotopes; D008297:Male; D008551:Melena; D051379:Mice; D011832:Radiation Injuries / Q000150:complications*; D013921:Thrombocytopenia / Q000209:etiology
D007504:Iron Radioisotopes
Uber den Nachweis der Magen-Darm-Blutungen beim akuten Strahlensyndrom