Cross-reactivity between H-2K and H-2D products. I. Evidence for extensive and reciprocal serological cross-reactivity.
Serological cross-reactivity between the products of the H-2K and H-2D genes has been demonstrated by a design in which antibody was produced against determinants controlled by one locus (e .g . H-2K(k)), and then tested against the product of the opposite locus (e .g . H-2D(d)). A total of 13 out of 18 such test combinations exhibited H-2K-H-2D cross-reactivity. The presence or absence of cross-reactivity was reciprocal in most cases (i.e. antibody directed against the H-2K(k) gene product reacted with H-2(d) determinants, and antibody directed against the H-2D(d) gene product reacted with H-2K(k) determinants). An Ia-like reaction was detected with one antiserum which implied possible cross-reactivity between the products of two discrete la genes.
D000818:Animals; D002874:Chromosome Mapping; D003429:Cross Reactions; D003601:Cytotoxicity Tests, Immunologic; D005796:Genes; D005838:Genotype; D006384:Hemagglutination; D006649:Histocompatibility Antigens; D051379:Mice; D008809:Mice, Inbred C3H; D014176:Protein Biosynthesis; D011995:Recombination, Genetic; D016038:Skin Transplantation; D014184:Transplantation, Homologous
D006649:Histocompatibility Antigens