The effect of ubiquinone-7 and its metabolites on the immune response. II. Adjuvant activity on the circulating antibody production and the effect on the liver lysosomal membrane.
The effects of the fat-soluble vitamins (retinol, alpha-tocopherol, phylloquinone and ubiquinone) and their related compounds were investigated on the immune response in vivo. E acid-I, dihydro E acid-I, ES-6, K acid-I, Q acid-II and QS-3 act as adjuvants on the production of circulating antibody to bacterial alpha-amylase in mice when they are immunized with in the water phase of water-in-oil emulsion. These compounds, however, can not act as adjuvants in enhancing helper activity of carrier-primed T-cells using an adoptive transfer system in mice. It is also shown that these compounds have no adjuvant activity on the development of delayed type hypersensitivity to ABA-N-acetyltyrosine in guinea pigs. No definite correlation between the adjuvant activity of these compounds and their labilizing activity on rat-liver lysosomal membrane was found.
D000276:Adjuvants, Immunologic; D000818:Animals; D000917:Antibody Formation / Q000187:drug effects*; D005260:Female; D006168:Guinea Pigs; D006968:Hypersensitivity, Delayed; D008099:Liver / Q000276:immunology; D008247:Lysosomes / Q000276:immunology; D008297:Male; D051379:Mice; D051381:Rats; D013601:T-Lymphocytes / Q000276:immunology; D014451:Ubiquinone / Q000031:analogs & derivatives / Q000494:pharmacology*; D014801:Vitamin A / Q000494:pharmacology; D014810:Vitamin E / Q000494:pharmacology*; D010837:Vitamin K 1 / Q000031:analogs & derivatives / Q000494:pharmacology*
D000276:Adjuvants, Immunologic; D014801:Vitamin A; D014451:Ubiquinone; D014810:Vitamin E; D010837:Vitamin K 1