[Morphological characteristics of the internal organs of experimental animals after administration of different doses of chanerol].
Experiments were conducted  with rats and dogs to study the influence of different hanerol doses on the condition of anumber of internal organs. The drug was introduced in a single dose: to rats in the form of a 0.1% solution in amounts of 6, 8, 10, 13, 20 and 30 mg/kg and to dogs as a 0.1% solution in doses of 24 mg/kg. Doses of 20 and 30 mg/kg for rats and 24 mg/kg for dogs proved intolerable and animals perished in consequence of circulatory disturbances (blood effusion, thrombosis of capillaries in the lungs, spleen, suprarenals and in organs of the gastro-intestinal tract). On application of doses amounting to 6 and 13 mg/kg in rats and 6-12 in dogs the animals remained alive, although the lungs, testes and the spleen were found to be afflicted with thrombosis of individual capillaries and there was demonstrable the the development of pneumosclerotic foci, atrophy of spermatogenic epithelium and slight splenic infarctions.
D000311:Adrenal Glands / Q000098:blood supply; D000818:Animals; D002196:Capillaries / Q000473:pathology; D004285:Dogs; D005753:Gastric Mucosa / Q000473:pathology; D006471:Gastrointestinal Hemorrhage / Q000139:chemically induced* / Q000473:pathology; D007275:Injections, Intravenous; D007511:Ischemia / Q000139:chemically induced* / Q000473:pathology; D008168:Lung / Q000098:blood supply; D019684:Magnoliopsida; D008297:Male; D010636:Phenols / Q000008:administration & dosage* / Q000009:adverse effects; D010936:Plant Extracts; D011658:Pulmonary Fibrosis / Q000139:chemically induced* / Q000473:pathology; D051381:Rats; D013154:Spleen / Q000098:blood supply; D013737:Testis / Q000098:blood supply; D013927:Thrombosis / Q000139:chemically induced* / Q000473:pathology
D010636:Phenols; D010936:Plant Extracts; C057686:chanerol
Morfologicheskaia kharakteristika vnutrennikh organov eksperimental'nykh zhivotnykh pri primenenii razlichnykh doz khanerola.