Comparison of ampicillin and trimethoprim-sulfamethoxazole in the short-term treatment of urinary tract infection.
Two groups, each of 20 patients, with urinary tract infection were randomly chosen and treated according to a double-blind procedure with either ampicillin, 500 mg, or trimethoprimsulfamethoxazole, either drug being given 4 times daily for 10 days. A number of features of the infections were studied: the occurrence of single or multiple attacks, the presence or absence of complications whether the lower or upper urinary tract was affected, favourably with ampicillin in sterilizing the urine of patients and the bacteria involved. Trimethoprim-sulfamethoxazole was found to compare with multiple and complicated urinary tract infections during a follow-up period of 3 months.
D000293:Adolescent; D000328:Adult; D000368:Aged; D000667:Ampicillin / Q000008:administration & dosage / Q000627:therapeutic use*; D001424:Bacterial Infections / Q000188:drug therapy*; D002986:Clinical Trials as Topic; D004338:Drug Combinations; D004341:Drug Evaluation; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D013420:Sulfamethoxazole / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D014295:Trimethoprim / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D014552:Urinary Tract Infections / Q000188:drug therapy*
D004338:Drug Combinations; D000667:Ampicillin; D014295:Trimethoprim; D013420:Sulfamethoxazole