T and CR+ lymphocyte profile in leprosy and the effect of treatment.
Thymus-derived lymphocytes (T lymphocytes) and complement receptor-bearing lymphocytes (CR+ lymphocytes) were estimated by using erythrocyte rosettes and erythrocyte-antibody-complement rosettes as markers in untreated lepromatous and untreated tuberculoid patients and in healthy controls. Treated lepromatous cases were also investigated. Ten cases of untreated lepromatous patients were reassessed 6 months or more after therapy commenced. A significant decrease in both percentages and absolute numbers of CR+ cells in the untreated lepromatous leprosy subjects was observed. This decrease showed a return to normal levels after treatment. The percentage of T cells in the untreated lepromatous cases was normal; however, the absolute numbers of T cells and the total lymphocyte count showed a significant decrease. After therapy, the T cell population was unchanged but the total number of lymphocytes increased significantly with treatment. The absolute number of T and CR+ cells was significantly less in the untreated than in the treated lepromatous patients.
D001772:Blood Cell Count; D003165:Complement System Proteins / Q000378:metabolism*; D006801:Humans; D007104:Immune Adherence Reaction; D007918:Leprosy / Q000188:drug therapy / Q000276:immunology*; D008214:Lymphocytes; D011955:Receptors, Drug / Q000187:drug effects*; D013601:T-Lymphocytes; D013997:Time Factors
D011955:Receptors, Drug; D003165:Complement System Proteins