title: Specific and nonspecific cooperation between M-locus-incompatible T and B cells during adoptive anti-hapten antibody responses in mice.
abstract: CBA and AKR mice are identical at the major histocompatibility locus (H-2) but differ at the strong, non-H-2, mixed leukocyte culture (MLC)-stimulating M-locus. Adoptive secondary in vivo antibody responses using immune spleen cells from mice of these strains demonstrate two interesting findings. One is a non-specific augmentation of the anti-hapten antibody response of CBA B cells by AKR T cells. This allogeneic effect is unidirectional in the same sense as the MLC between cells from these two strains. The second is that, despite an ongoing allogeneic effect, M-locus-incompatible T and B cells show strong specific cooperation. Thus, it seems unlikely that the failure of H-2-incompatible T and B cells to collaborate specifically is due to inhibitory allogenic reactions.
mesh_terms: D000818:Animals; D000906:Antibodies / Q000032:analysis; D001402:B-Lymphocytes / Q000276:immunology* / Q000637:transplantation; D006241:Haptens / Q000032:analysis; D006648:Histocompatibility; D007111:Immunity, Cellular; D007112:Immunity, Maternally-Acquired; D051379:Mice; D008806:Mice, Inbred AKR; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D013154:Spleen / Q000166:cytology; D013601:T-Lymphocytes / Q000276:immunology* / Q000637:transplantation; D014184:Transplantation, Homologous; D014185:Transplantation, Isogeneic
chemical_list: D000906:Antibodies; D006241:Haptens