[Pyrazolic sulfanilamides. XIV. Hydroxyderivatives of 1-phenyl-5-sulfanilamidopyrazole and of 1-phenyl-3-methyl-5-sulfanilamidopyrazole].
A report is given of the variations in bacteriostatic activity on introduction of a hydrophilic group, the hydroxyl group (-OH), at positions 2',3' and 4' of the phenyl group linked to the heterocyclic nitrogen os 1-phenyl-5-sulfanilamidopyrazole (I: R = -H) and of 1-phenyl-3-methyl-5-sulfanilamidopyrazole (II: R = -H). The substances prepared for this purpose: 1-(hydroxyphenyl)-5-sulfanilamidopyrazoles (Ia)(Ib))(Ic)(-OH at 2', 3',4') and 1-(hydroxyphenyl)-3-methyl-5-sulfanilamidopyrazoles (IIa)(IIb)(IIc)(-OH at 2',3'4') in vitro tests of bacteriostatic activity against strains of S. aureus and E. coli gave the following results: See journal for results.
D004926:Escherichia coli / Q000187:drug effects; D013058:Mass Spectrometry; D008826:Microbial Sensitivity Tests; D011720:Pyrazoles / Q000138:chemical synthesis* / Q000494:pharmacology; D013055:Spectrophotometry, Infrared; D013424:Sulfanilamides / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000494:pharmacology
D011720:Pyrazoles; D013424:Sulfanilamides
Sulfanilammidi pirazoliche. XIV. Idrossiderivati dell'1-fenil-5-sulfanilammmidopirazolo e dell'1-fenil-3-metil-5-sulfanilammidopirazolo