Isolation and properties of a thymidylate-less mutant in Saccharomyces cerevisiae.
A mutant, tmp3, has been isolated in Saccharomyces cerevisiae. Genetic and physiological analysis show that a single mendelian gene controls the multiple requirements for thymidylate, methionine, adenine and histidine and a neutral cytoplasmic petite character. Crude extracts of this mutant present a 60% decrease of serine transhydroxymethylase specific activity as compared to a wild-type strain.
D000225:Adenine / Q000494:pharmacology; D005492:Folic Acid / Q000494:pharmacology; D005796:Genes; D012696:Glycine Hydroxymethyltransferase / Q000378:metabolism; D006639:Histidine / Q000494:pharmacology; D008715:Methionine / Q000494:pharmacology; D009154:Mutation; D012441:Saccharomyces cerevisiae / Q000187:drug effects / Q000302:isolation & purification / Q000378:metabolism*; D013045:Species Specificity; D013942:Thymine Nucleotides / Q000378:metabolism* / Q000494:pharmacology
D013942:Thymine Nucleotides; D006639:Histidine; D005492:Folic Acid; D008715:Methionine; D012696:Glycine Hydroxymethyltransferase; D000225:Adenine