title: Effect of the antiepileptic drug sodium valproate on induction of hepatic microsomal P450.
abstract: Sodium valproate is an anticonvulsant which, unlike phenobarbitone, does not produce an increase in rat hepatic P450 when given in large nontherapeutic doses.
mesh_terms: D000818:Animals; D000927:Anticonvulsants / Q000494:pharmacology*; D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism*; D004790:Enzyme Induction / Q000187:drug effects; D008297:Male; D008862:Microsomes, Liver / Q000201:enzymology*; D010634:Phenobarbital / Q000494:pharmacology; D011189:Potassium Chloride / Q000494:pharmacology; D051381:Rats; D014631:Valerates / Q000494:pharmacology*; D014635:Valproic Acid / Q000494:pharmacology*
chemical_list: D000927:Anticonvulsants; D014631:Valerates; D014635:Valproic Acid; D011189:Potassium Chloride; D003577:Cytochrome P-450 Enzyme System; D010634:Phenobarbital