[Intrauterine sensitization to benzylpenicillin in an experiment on rabbits].
Antibodies of benzylpenicillin in the posterity of various ages of female rabbits were found with reaction of passive hemagglutination (RPHA) and degranulation of the basophiles after their immunization with the antibiotic. This provided an assumption of intrauterine sensitization. Treatment of the sera of the sensitized animals with 2-mercaptoethanol partially decreased their activity in the RPHA which indicated to the presence of the antibodies of classes IgG and IgM.
D000367:Age Factors; D000371:Agglutination / Q000187:drug effects; D000667:Ampicillin / Q000494:pharmacology; D000818:Animals; D000906:Antibodies / Q000032:analysis; D001491:Basophils / Q000276:immunology; D005260:Female; D005333:Fetus / Q000276:immunology; D006386:Hemagglutination Tests; D007114:Immunization; D007115:Immunization Schedule; D007074:Immunoglobulin G / Q000032:analysis; D007075:Immunoglobulin M / Q000032:analysis; D007158:Immunologic Techniques; D007279:Injections, Subcutaneous; D007428:Intradermal Tests; D008431:Maternal-Fetal Exchange / Q000187:drug effects*; D008623:Mercaptoethanol / Q000276:immunology; D010400:Penicillin G / Q000276:immunology*; D011247:Pregnancy; D011817:Rabbits; D013997:Time Factors
D000906:Antibodies; D007074:Immunoglobulin G; D007075:Immunoglobulin M; D008623:Mercaptoethanol; D000667:Ampicillin; D010400:Penicillin G
Vnutriutrobnaia sensibilizatsiia k benzilpenitsillinu v éksperimente na krolikakh