Immunologic characterization of the mononuclear cell infiltrates in rheumatoid synovia, in rheumatoid nodules, and in lip biopsies from patients with Sjögren's syndrome.
Two subcutaneous rheumatoid nodules and 8 rheumatoid synovia from patients with rheumatoid arthritis (RA); and 2 parotid glands, 1 "pseudolymphoma," and 6 lip biopsies from patients with Sjogren's syndrome (SS) were studied to identify mononuclear cells. The palisading mononuclear cells in subcutaneous nodules had a surface membrane receptor for complement. B lymphocytes surrounded by larger numbers of non-B lymphocytes were found in RA synovium and between salivary ducts of SS lip biopsies. A "pseudolymphoma" obtained from a patient with SS consisted primarily of B lymphocytes. The predominant mononuclear cell in rheumatoid synovia and salivary glands in patients with RA and SS do not have surface membrane receptors from complement and are thus probably T lymphocytes or null cells.
D000818:Animals; D001666:Binding Sites, Antibody; D001706:Biopsy; D002462:Cell Membrane / Q000276:immunology; D003165:Complement System Proteins; D004912:Erythrocytes / Q000276:immunology; D006644:Histiocytes / Q000276:immunology; D006801:Humans; D007106:Immune Sera; D008046:Lip / Q000276:immunology / Q000473:pathology*; D008223:Lymphoma / Q000276:immunology; D009000:Monocytes / Q000276:immunology*; D010306:Parotid Gland / Q000276:immunology; D010950:Plasma Cells / Q000276:immunology; D012218:Rheumatoid Nodule / Q000276:immunology*; D012756:Sheep; D012859:Sjogren's Syndrome / Q000276:immunology* / Q000473:pathology; D013583:Synovial Membrane / Q000276:immunology*; D013601:T-Lymphocytes / Q000276:immunology*
D007106:Immune Sera; D003165:Complement System Proteins