[Observation in 10 calves with a survival time of more than 100 hours after total heart replacement (author's transl)].
It is reported on 10 calves surviving total artificial heart replacement more than 100 hours. Pneumatically driven double-chambered blood pumps made of silastic were implanted. During the experiments an increase of the right atrial pressure as well as a rise of the perfusion volumes (CO) and of the blood volumes could be found regularly. At autopsy congestion of the organs especially of the liver was a regular finding. The changed hemodynamic is first seen as possible reason for this developments. The influence of anemia and the possible disturbances in the neurohumoral autoregulation of the animals by unphysiologic pressure curves are discussed.
D000818:Animals; D001158:Arteries / Q000503:physiopathology; D001201:Ascites; D001810:Blood Volume; D002417:Cattle; D005260:Female; D006354:Heart, Artificial; D006400:Hematocrit; D006439:Hemodynamics; D008099:Liver / Q000473:pathology; D008102:Liver Circulation; D008297:Male; D009929:Organ Size; D010101:Oxygen Consumption; D011654:Pulmonary Edema; D014655:Vascular Resistance
Beobachtungen an 10 Kälbern, die den Totalersatz des Herzens mehr als 100 Stunden überlebten