[The endotoxin from S-, R- and M-forms of enteropathogenic E. coli O 149: pyrogenicity, Shwartzman-phenomenon and hypersensitivity (author's transl)].
The authors are interested in elucidation of the role of endotoxin from S, R- and M-forms of E. coli O 149, and of the role of hypersensitivity in pathogenesis of Colibacillosis. It was shown in this experiment that all S, R- and M-form of E. coli O149 possess endotoxin with almost the same pyrogenicity in normal rabbits. The pyrogenicity increases enormously in the hypersensitized rabbit. There were also not observed differences between endotoxins extracted from S, R, M-mutnants. All 3 endotoxins evoke in normal rabbits the skin Shwartzman-Phenomenon, the S-endotoxin was there much stronger. This phenomenon increases in capacity in hypersensitized rabbits. Thus again, the role of hypersensitivity in Colibacillosis was proved to be important.
D000818:Animals; D000942:Antigens, Bacterial; D001835:Body Weight; D004731:Endotoxins / Q000008:administration & dosage / Q000494:pharmacology*; D004890:Erythema / Q000209:etiology; D004926:Escherichia coli / Q000276:immunology; D006967:Hypersensitivity; D007106:Immune Sera; D011749:Pyrogens / Q000494:pharmacology*; D011817:Rabbits; D013045:Species Specificity; D013997:Time Factors
D000942:Antigens, Bacterial; D004731:Endotoxins; D007106:Immune Sera; D011749:Pyrogens
Das Endotoxin der S-, 4- und M-Formen der enteropathogenen E. coli O 149: Pyrogenität, Shwartzman-Phänomen und die hypersensitivität