title: Off-signals in lymphocyte activation.
abstract: High-dose unresponsiveness to concanavalin A affected T and B lymphocytes equally, although only T cells were activated by Con A. Thus, activation and inactivation signals are totally unrelated, the latter also lacking target cell specificity. The off-signal caused cell death and is probably biologically unimportant.
mesh_terms: D000818:Animals; D001402:B-Lymphocytes / Q000276:immunology*; D002470:Cell Survival / Q000187:drug effects; D003208:Concanavalin A / Q000008:administration & dosage / Q000494:pharmacology*; D004247:DNA / Q000096:biosynthesis; D008070:Lipopolysaccharides / Q000494:pharmacology; D008213:Lymphocyte Activation / Q000187:drug effects*; D051379:Mice; D008807:Mice, Inbred BALB C; D008819:Mice, Nude; D011135:Polysaccharides, Bacterial / Q000494:pharmacology; D013601:T-Lymphocytes / Q000276:immunology*
chemical_list: D008070:Lipopolysaccharides; D011135:Polysaccharides, Bacterial; D003208:Concanavalin A; D004247:DNA