[Transport of D-xylose in isolated frog sartorius muscle in the presence of actinomycin D].
The action of actinomycin D on the basal and insulin stimulated D-xylose uptake has been studied on isolated frog sartorius muscles. Actinomycin D at concentrations of 10 mg/ml or 100 mg/ml exerts no effect on the basal transport of sugar and causes no alteration in the response to insulin. The distribution coefficient of actinomycin D in muscle tissue is equal 0,9--1. It is supposed that the inhibition of RNA synthesis by antibiotics does not influence sugar transport.
D000818:Animals; D003609:Dactinomycin / Q000494:pharmacology*; D066298:In Vitro Techniques; D007328:Insulin / Q000494:pharmacology; D009132:Muscles / Q000187:drug effects / Q000378:metabolism*; D011896:Rana temporaria; D013268:Stimulation, Chemical; D014994:Xylose / Q000378:metabolism*
D007328:Insulin; D003609:Dactinomycin; D014994:Xylose
Transport D-ksilozy v izolirovannye portniazhnye myshtsy liaqushki v prisutsvii aktinomitsina D