Influence of various anesthetic drugs on the intraocular pressure of cats.
Cats with one normal eye and one eye with experimental glaucoma were trained to tolerate tonometry while conscious. They were then given the general anesthetic agents pentobarbital, ketamine, and CI-744 in the lowest and twice the lowest dosages which permitted tonometry in untrained cats. Pentobarbital lowered intraocular pressure (IOP) by 20-50%. Ketamine raised IOP by about 10%. CI-744 had essentially no effect on IOP. The two conpoments of CI-744, tiletamine (CI-634) and zolazepam (CI-716) were given individually in the doses in which they had been given as part of CI-744. Tiletamine had no effect on IOP, while zolazepam lowered IOP by about 10%.
D000777:Anesthetics / Q000494:pharmacology*; D000818:Animals; D001381:Azepines / Q000494:pharmacology; D002415:Cats; D004338:Drug Combinations; D005260:Female; D005901:Glaucoma; D007429:Intraocular Pressure / Q000187:drug effects*; D007649:Ketamine / Q000494:pharmacology; D008297:Male; D010424:Pentobarbital / Q000494:pharmacology; D013992:Tiletamine / Q000494:pharmacology; D014065:Tonometry, Ocular
D000777:Anesthetics; D001381:Azepines; D004338:Drug Combinations; D013992:Tiletamine; D007649:Ketamine; D010424:Pentobarbital