Antinative DNA antibodies as a reaction to pyrazole drugs.
A case history is presented of the occurrence of a high binding capacity for native DNA in the serum of a patient on phenylbutazone. This reverted to normal on stopping the drug. The patient also had a reversible neutropenia and leucopenia, and it is suggested that the high anti-DNA binding capacity was a feature of a drug-induced lupus-like phenomenon.
D000906:Antibodies / Q000032:analysis; D000974:Antibodies, Antinuclear / Q000032:analysis; D000989:Antistreptolysin / Q000032:analysis; D001665:Binding Sites / Q000187:drug effects; D001666:Binding Sites, Antibody; D006801:Humans; D007213:Indomethacin / Q000627:therapeutic use; D007958:Leukocyte Count; D007970:Leukopenia / Q000139:chemically induced; D008297:Male; D008875:Middle Aged; D009503:Neutropenia / Q000139:chemically induced; D010113:Oxyphenbutazone / Q000009:adverse effects / Q000627:therapeutic use; D010653:Phenylbutazone / Q000009:adverse effects* / Q000627:therapeutic use; D013167:Spondylitis, Ankylosing / Q000188:drug therapy / Q000276:immunology
D000906:Antibodies; D000974:Antibodies, Antinuclear; D000989:Antistreptolysin; D010653:Phenylbutazone; D010113:Oxyphenbutazone; D007213:Indomethacin