Investigations on the influence of different corticosteroids on the development of galactose cataracts in rats.
The influence of daily subcutaneous injections of 5 different corticosteroids (15 mg/kg body weight) on the development of galactose opacities in young rats of approximately 60g body weight was investigated. Progress of cataracts was evaluated by planimetry of lens photos. The three glucocorticosteroids used (cortisol, prednisolone, fluocortolone) induced a slight acceleration of cataract development, while a mineralocorticoid (desoxy-corticosterone) caused a marked retardation. A temporary retardation was also observed with fluocortinbutyl, a rapidly metabolized steroid for topical use.
D000305:Adrenal Cortex Hormones / Q000009:adverse effects*; D000818:Animals; D001835:Body Weight / Q000187:drug effects; D002386:Cataract / Q000139:chemically induced*; D003900:Desoxycorticosterone / Q000009:adverse effects; D004357:Drug Synergism; D005260:Female; D005448:Fluocortolone / Q000009:adverse effects / Q000031:analogs & derivatives; D005690:Galactose; D006854:Hydrocortisone / Q000009:adverse effects; D011239:Prednisolone / Q000009:adverse effects; D051381:Rats
D000305:Adrenal Cortex Hormones; D003900:Desoxycorticosterone; D005448:Fluocortolone; D011239:Prednisolone; D006854:Hydrocortisone; D005690:Galactose