title: [Does methylmethacrylate induce cardiovascular complications during alloarthroplastic surgery of the hip joint? (AUTHOR'S TRANSL)].
abstract: Cardiovascular experiments in dogs and rabbits under various conditions demonstrated that monomethylacrylate has no direct cardiac depressant activity. The transient decrease in blood pressure and heart rate of patients receiving endoprostheses and experimental animals is elicited by a vagotropic effect of the methacrylates and can be antagonized by prophylactic application of atropine. Severe cardiovascular incidents involving an acute cor pulmonale are induced via the steep rise in pressure within the bone-marrow canal during the forcing in of the endoprosthetic shafts, leading to intravasation of bone marrow and its thromboplastine like compounds, thus resulting in a partial coagulation. A schedule of simple prophylactic procedures proved to be effective in preventing fatal cardiovascular complications.
mesh_terms: D000818:Animals; D007611:Aprotinin / Q000627:therapeutic use; D001285:Atropine / Q000627:therapeutic use; D001778:Blood Coagulation Disorders / Q000517:prevention & control; D001794:Blood Pressure / Q000187:drug effects; D001843:Bone Cements / Q000009:adverse effects*; D002318:Cardiovascular Diseases / Q000139:chemically induced*; D004620:Embolism, Fat; D005260:Female; D006321:Heart / Q000187:drug effects; D006339:Heart Rate / Q000187:drug effects; D006439:Hemodynamics / Q000187:drug effects; D006621:Hip Joint; D007022:Hypotension / Q000139:chemically induced / Q000517:prevention & control; D007595:Joint Prosthesis / Q000009:adverse effects*; D008297:Male; D008768:Methylmethacrylates / Q000009:adverse effects* / Q000097:blood / Q000494:pharmacology; D008833:Microcirculation; D011312:Pressure; D011652:Pulmonary Circulation; D011817:Rabbits
chemical_list: D001843:Bone Cements; D008768:Methylmethacrylates; D001285:Atropine; D007611:Aprotinin
vernacular_title: Sind intraoperative Kreislaufkomplikationen bei Alloarthroplastiken des Hüftgelenks durch Methylmethacrylat bedingt