Oestrogen therapy and serum cortisol in carcinoma of the prostate.
Patients with prostatic cancer, receiving oestrogen therapy were found to have elevated serum cortisol levels and lymphopenia. Oestrogens are known to have a profound effect on the immune system; the possibility that this effect is mediated through the adrenal cortex is discussed. The significance of these findings, however, remains to be determined.
D000368:Aged; D002986:Clinical Trials as Topic; D004967:Estrogens / Q000627:therapeutic use*; D006801:Humans; D006854:Hydrocortisone / Q000097:blood*; D007111:Immunity, Cellular / Q000187:drug effects; D007958:Leukocyte Count; D008214:Lymphocytes; D008231:Lymphopenia / Q000209:etiology; D008297:Male; D008875:Middle Aged; D011471:Prostatic Neoplasms / Q000097:blood / Q000188:drug therapy*
D004967:Estrogens; D006854:Hydrocortisone