title: Chromatographic hydrophobic parameters in correlation analysis of structure-activity relationships.
abstract: The use of RM and delta RM parameters as indices of hydrophobicity for inclusion in quantitative structure activity relationships has been studied. The relationship between these parameters and other free-energy related parameters is illustrated theoretically and experimentally. It is suggested that the chromatographically obtained parameters could find a wider applicability in structure-activity relationships, and that their use would result in improved correlation of data.
mesh_terms: D000042:Absorption; D000700:Analgesics / Q000032:analysis; D001431:Bacteriological Techniques; D001665:Binding Sites; D001693:Biological Transport, Active; D002845:Chromatography; D004563:Electrochemistry; D004735:Energy Transfer; D008433:Mathematics; D008722:Methods; D010575:Pesticides / Q000032:analysis; D004364:Pharmaceutical Preparations / Q000378:metabolism; D011485:Protein Binding; D013237:Stereoisomerism; D013256:Steroids / Q000032:analysis; D013329:Structure-Activity Relationship; D014116:Toxicology
chemical_list: D000700:Analgesics; D010575:Pesticides; D004364:Pharmaceutical Preparations; D013256:Steroids