Characteristics of two broad spectrum antibiotics produced by Mycoplasma sp. RP III.
Two extracellular antibiotics produced by Mycoplasma sp. RP III growing in serum-containing media have been purified by solvent extraction and ion-exchange chromatography. Factor I inhibits Gram-positive and Gram-negative bacteria in vitro and a crude preparation protected mice from Pseudomonas and Straphylococcus infections; it is of low cytotoxicity. Factor II, a lipid, inhibits Gram-positive and Gram-negative bacteria, Candida species, and is as cytotoxic as the actinomycins.
D000818:Animals; D000900:Anti-Bacterial Agents / Q000302:isolation & purification* / Q000494:pharmacology; D001431:Bacteriological Techniques; D003470:Culture Media; D051379:Mice; D009174:Mycoplasma / Q000378:metabolism*; D011549:Pseudomonas / Q000187:drug effects
D000900:Anti-Bacterial Agents; D003470:Culture Media