T lineage lymphocytes in nude mice born from homozygous nu/nu parents.
T lineage cells are found in the spleen of neonatal nu/nu mice born from nu/nu x nu/nu matings, and also in old, healthy nude mice obtained from the usual nu/+ x nu/nu matings. Their presence in neonatal nude mice which were never in contact with mother or normal littermate thymus products shows that commitment of stem cells towards the T lineage does not require the influence of the thymus.
D000375:Aging; D000818:Animals; D000831:Animals, Newborn; D002452:Cell Count; D006720:Homozygote; D051379:Mice; D008819:Mice, Nude; D013601:T-Lymphocytes