title: alpha-1-Anti-trypsin, an inhibitor of renin.
abstract: A naturally occurring competitive inhibitor of pig kidney renin has been identified in human plasma. The inhibitor was shown to be alpha-1 anti-trypsin and the effect in vitro on the renin activity was examined. The slope in the Hill plot is compatible with the assumption of one-site competitive inhibition. Other proteinase inhibitors, such as alpha-2-macroglobulin and C1 inactivator, however, have no inhibitory effect on the renin-angiotensinogen reaction.
mesh_terms: D000818:Animals; D006801:Humans; D013552:Swine; D000515:alpha 1-Antitrypsin / Q000494:pharmacology*; D000092502:Renin Inhibitors
chemical_list: D000515:alpha 1-Antitrypsin; D000092502:Renin Inhibitors