Evidence for a neuromuscular disorder in methylmercury poisoning.
Data suggestive of a neuromuscular disorder responsive to neostigmine was uncovered in the course of electrophysiological testing of Iraqi patients poisoned by methylmercury. Subsequent neostigmine therapy produced a remarkable clinical improvement of the patients. Placebo substitution resulted in a substantial loss of testable strength that was restored when drug therapy was resumed.
D000328:Adult; D002648:Child; D002986:Clinical Trials as Topic; D004576:Electromyography; D004594:Electrophysiology; D005260:Female; D006801:Humans; D007493:Iraq; D008297:Male; D008630:Mercury Poisoning / Q000209:etiology* / Q000503:physiopathology; D008767:Methylmercury Compounds / Q000506:poisoning*; D009132:Muscles / Q000503:physiopathology; D009388:Neostigmine / Q000008:administration & dosage / Q000627:therapeutic use; D009431:Neural Conduction; D009468:Neuromuscular Diseases / Q000139:chemically induced* / Q000188:drug therapy / Q000503:physiopathology; D009469:Neuromuscular Junction / Q000503:physiopathology; D010525:Peripheral Nerves / Q000503:physiopathology*; D010919:Placebos
D008767:Methylmercury Compounds; D010919:Placebos; D009388:Neostigmine