Antibody response of C3H in equilibrium (CKB X CWB)F1 tetraparental mice to poly-L(Tyr,Glu)-poly-D,L-Ala-poly-L-Lys immunization.
To test whether the antigen-specific stimulation of low responder-genotype B cells in tetraparental mice is due to a histoincompatibility reaction (allogeneic effect) against these B cells, tetraparental mice were constructed (a) between an Ir-1A low responder to the antigen poly-L(Tyr,Glu)-poly-D,L-Ala--poly-L-Lys. [(T,G)-A--L] and an Ir-1A F1 high responder and (b) between two histoincompatible Ir-lA low responders. In the first case the F1 high responder embryo shares the whole of the H-2 complex, including Ir, with the low responder embryo.
D000818:Animals; D000906:Antibodies / Q000032:analysis; D000917:Antibody Formation; D001402:B-Lymphocytes / Q000276:immunology; D002678:Chimera; D005796:Genes; D006649:Histocompatibility Antigens; D007126:Immunoglobulin Allotypes; D007519:Isoantigens; D051379:Mice; D008815:Mice, Inbred Strains; D008954:Models, Biological; D010455:Peptides / Q000276:immunology
D000906:Antibodies; D006649:Histocompatibility Antigens; D007126:Immunoglobulin Allotypes; D007519:Isoantigens; D010455:Peptides