title: [Fatal course of generalized BCG histiocytosis in congenital immune deficiency (author's transl)].
abstract: Severe combined X-linked immune deficiency ended fatally in a six-month-old male infant after generalized BCG infection. Damage in the cell-bound thymus-dependent immune system is decisive in the development of "BCG histiocytosis". As a result of absent immunocompetent sensitized T-lymphocytes there is insufficient information and stimulation of macrophages to kill the micro-organsims. The disorder of bactericidal properties of macrophages results in an overwhelming infection with BCG bacteria with a characteristic morphological picture.
mesh_terms: D001500:BCG Vaccine / Q000009:adverse effects*; D001769:Blood; D006801:Humans; D007111:Immunity, Cellular; D007153:Immunologic Deficiency Syndromes / Q000150:complications*; D007223:Infant; D008264:Macrophages; D008297:Male; D010019:Osteomyelitis / Q000209:etiology; D013601:T-Lymphocytes / Q000276:immunology; D014374:Tuberculin Test
chemical_list: D001500:BCG Vaccine
vernacular_title: Tödlicher Verlauf einer generalisierten BCG-Histiozytose bei angeborenem Immundefekt