title: The influence of histocompatibility and antithymocyte serum on the ability of alloantigenic pretreatment to prolong the survival of mouse skin grafts.
abstract: Test skin allografts enjoy prolonged survival when alloantigenic pretreatment (implants of small fragments of liver or kidney on the host's kidney cortex) is separated from test grafting by 9 days and donor and host strains differ only at the relatively weak H-3 + H-13 histocompatibility barrier (Baldwin and Cohen 1971, 1974). However, test skin grafts are rejected in an accelerated fashion when this protocol is followed but the donor strains differ at stronger non-H-2 barriers. In 2 such strain combinations in which control first-set grafts are rejected acutely, varying the implant-to-test graft interval, using F-1 mice as implant donors, or varying the sex of the donors and hosts, all failed to prolong test graft SURVIVAL. However, survival of some test grafts was significantly greater following a combined host treatment of alloimplanatation and ATS than it was following either procedure alone. This synergism suggests that across stronger H-barriers, alloantigenic pretreatment does elicit an immunosuppressive component whose effective presence is normally masked by thymus-dependent cell-mediated immunity.
mesh_terms: D000818:Animals; D000961:Antilymphocyte Serum; D002470:Cell Survival / Q000187:drug effects; D006084:Graft Rejection / Q000187:drug effects; D006649:Histocompatibility Antigens; D007166:Immunosuppressive Agents / Q000494:pharmacology; D051379:Mice; D008807:Mice, Inbred BALB C / Q000276:immunology; D008809:Mice, Inbred C3H / Q000276:immunology; D008808:Mice, Inbred CBA / Q000276:immunology; D008811:Mice, Inbred DBA / Q000276:immunology; D016038:Skin Transplantation; D013601:T-Lymphocytes / Q000276:immunology*; D014184:Transplantation, Homologous
chemical_list: D000961:Antilymphocyte Serum; D006649:Histocompatibility Antigens; D007166:Immunosuppressive Agents