title: [Spontaneous and induced autoxidation of phospholipids during conformational rearrangements in outer segment membranes of frog retinal rods].
abstract: Kinetics of spontaneous and induced by the system Fe+++ascorbate peroxide oxidation of lipids in the membranes of outer segments of frog retina rods has been studied. Free radical oxidation of phospholipids passes the same stages as liquid phase oxidation of alkenes. Docosahexaenoi fatty acid residue of phosphatidyletanolamine is the main substrate of autooxidation. The structural organization of photoreceptor membranes is the factor which controls the reaction rate of peroxide oxidation; and reconstructions in membrane organization (at rhodopsin photolysis) result in the changes of autooxidation rate of phospholipids in the membrane.
mesh_terms: D000818:Animals; D001001:Anura; D001205:Ascorbic Acid / Q000494:pharmacology; D005609:Free Radicals; D066298:In Vitro Techniques; D007501:Iron / Q000494:pharmacology; D008566:Membranes / Q000187:drug effects / Q000378:metabolism; D008968:Molecular Conformation; D010084:Oxidation-Reduction; D010545:Peroxides / Q000378:metabolism; D010743:Phospholipids / Q000378:metabolism*; D010786:Photoreceptor Cells / Q000187:drug effects / Q000378:metabolism*; D011896:Rana temporaria
chemical_list: D005609:Free Radicals; D010545:Peroxides; D010743:Phospholipids; D007501:Iron; D001205:Ascorbic Acid
vernacular_title: Spontannoe i indutsirovannoe avtookislenie fosfolipidov pri konformatsionnykh perestroĭkakh membran naruzhykh segmentov palochek setchatki liagushki