title: Marek's disease in immunosuppressed chickens: growth of a transplantable lymphoma and development of the disease by natural exposure.
abstract: Evidence indicated that treatment of chickens with Cytoxan at hatching (bursectomy) had little effect on the development of transplantable Marek's disease (md) lymphoma. Cytoxan treatment of chickens at 2 and 3 weeks of age, however, apparently reduced the incidence of visceral tumors in chickens naturally exposed to MD. Amelioration of MD in immunosuppressed chickens was possibly mediated through suppression of MD-induced T-cell proliferation.
mesh_terms: D000367:Age Factors; D000818:Animals; D001835:Body Weight; D002060:Bursa of Fabricius / Q000033:anatomy & histology; D002645:Chickens; D003520:Cyclophosphamide / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D006084:Graft Rejection; D006388:Hemagglutinins / Q000032:analysis; D007165:Immunosuppression Therapy; D008380:Marek Disease / Q000276:immunology*; D009929:Organ Size; D011201:Poultry Diseases / Q000276:immunology*; D012756:Sheep / Q000276:immunology; D016038:Skin Transplantation; D013154:Spleen / Q000276:immunology; D014184:Transplantation, Homologous
chemical_list: D006388:Hemagglutinins; D003520:Cyclophosphamide