Effect of chlorpromazine on the respiration and hexose monophosphate dehydrogenases of gram-negative bacteria.
The drug chlorpromazine inhibits respiration in several gram-negative bacteria. The enzymes glucose-6-phosphogluconate dehydrogenase and 6-phosphogluconate dehydrogenase from these microorganisms are not affected by the drug.
D000091:Acetobacter / Q000201:enzymology / Q000378:metabolism; D001419:Bacteria / Q000201:enzymology / Q000378:metabolism*; D002474:Cell-Free System; D002746:Chlorpromazine / Q000494:pharmacology*; D002861:Chromobacterium / Q000201:enzymology / Q000378:metabolism; D004926:Escherichia coli / Q000201:enzymology / Q000378:metabolism; D005954:Glucosephosphate Dehydrogenase / Q000378:metabolism*; D010101:Oxygen Consumption / Q000187:drug effects*; D010734:Phosphogluconate Dehydrogenase / Q000378:metabolism*; D011549:Pseudomonas / Q000201:enzymology / Q000378:metabolism; D012706:Serratia marcescens / Q000201:enzymology / Q000378:metabolism; D013045:Species Specificity
D010734:Phosphogluconate Dehydrogenase; D005954:Glucosephosphate Dehydrogenase; D002746:Chlorpromazine