Immunologic chimerism as evidence of bone marrow graft acceptance in an identical twin with acute lymphocytic leukemia.
Bone marrow from a well child was infused into her identical twin who had acute lymphocytic leukemia. In an attempt to provide an immunologic tag for use in twin transplantation, the donor twin was immunized to Keyhole limpet hemocyanin (KLH) and yellow fever virus prior to the marrow infusion. Subsequent immunological chimerism in the recipient twin gave evidence for graft acceptance.
D001854:Bone Marrow Cells; D016026:Bone Marrow Transplantation; D002675:Child, Preschool; D002678:Chimera; D004200:Diseases in Twins; D005260:Female; D006433:Hemocyanins / Q000276:immunology; D006801:Humans; D007114:Immunization; D007945:Leukemia, Lymphoid / Q000276:immunology / Q000628:therapy*; D008213:Lymphocyte Activation; D009030:Mosaicism; D014184:Transplantation, Homologous; D015005:Yellow fever virus / Q000276:immunology
D006433:Hemocyanins