title: Thymus dependence of the IgA response to sheep erythrocytes.
abstract: The thumus dependence of the IgA response to sheep red blooc cells (SRBC) was studied by means of cell transfer experiments in mice. Only low numbers of IgM-, IgG- and IgA-plaque-forming cells (PFC) were observed in those recipients which received only spleen cells from adult thymectomized, irradiated and bone marrow-reconstituted mice (B cells). High numbers of IgM-, IgG- and IgA-PFC were observed when B cells and educated T cells were transferred to the recipients. Evidence is provided that B cells committed to IgA synthesis require the same degree of interaction with T cells as B cells committed to IgM synthesis, but a lower degree of interaction with T cells than B cells committed to IgG synthesis.
mesh_terms: D000818:Animals; D000917:Antibody Formation; D000921:Antibody-Producing Cells / Q000276:immunology; D001853:Bone Marrow / Q000528:radiation effects; D001854:Bone Marrow Cells; D004912:Erythrocytes / Q000276:immunology*; D005260:Female; D006462:Hemolytic Plaque Technique; D007116:Immunization, Passive; D007070:Immunoglobulin A / Q000096:biosynthesis*; D007074:Immunoglobulin G / Q000096:biosynthesis; D007075:Immunoglobulin M / Q000096:biosynthesis; D051379:Mice; D011828:Radiation Chimera; D011830:Radiation Effects; D012756:Sheep / Q000276:immunology; D013154:Spleen / Q000166:cytology / Q000528:radiation effects; D013601:T-Lymphocytes / Q000276:immunology*; D013934:Thymectomy
chemical_list: D007070:Immunoglobulin A; D007074:Immunoglobulin G; D007075:Immunoglobulin M