Effect of ibuprofen dosage on patient response in rheumatoid arthritis.
In a 4-week double-blind trial in 41 patients with rheumatoid arthritis, ibuprofen (Motrin) decreased the swollen joint count significantly at a dosage level of 2400 mg/day, but not at 1200 mg/day. Ibuprofen probably does have antiinflammatory effects in man, but only at higher dosages; antiarthritic activity at lower dosages reflects primarily analgesia and perhaps antipyretic effects. Complaints and clinical laboratory findings did not differ significantly between the dosage groups.
D000700:Analgesics / Q000008:administration & dosage* / Q000627:therapeutic use; D000893:Anti-Inflammatory Agents / Q000008:administration & dosage* / Q000009:adverse effects / Q000627:therapeutic use; D001172:Arthritis, Rheumatoid / Q000188:drug therapy*; D002986:Clinical Trials as Topic; D004361:Drug Tolerance; D006801:Humans; D007596:Joints / Q000187:drug effects; D008875:Middle Aged; D011422:Propionates / Q000008:administration & dosage* / Q000009:adverse effects / Q000627:therapeutic use
D000700:Analgesics; D000893:Anti-Inflammatory Agents; D011422:Propionates