Drug-induced tolerance: selective induction with immunosuppressive drugs and their synergistic interaction.
Drug-induced tolerance to polyinosinic-polycytidylic acid was studied in NZB/W mice. A single injection of cyclophosphamide (CY) or methotrexate (MTX) induced tolerance when given 24 h after antigen, whereas azathioprine (AZ) and methylprednisolone (MP) did not. However, MP and MTX each synergized with a nontolerogenic dose of CY. In addition, MP and AZ further reduced the tolerance induced by low but tolerogenic doses of CY. Drug combinations in the induction of tolerance may have wide application in the fields of clinical immunology and transplantation.
D000645:Ammonium Sulfate; D000818:Animals; D000941:Antigens; D001379:Azathioprine / Q000008:administration & dosage / Q000494:pharmacology; D002250:Carbon Radioisotopes; D003520:Cyclophosphamide / Q000008:administration & dosage / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D004357:Drug Synergism; D004912:Erythrocytes / Q000276:immunology; D006462:Hemolytic Plaque Technique; D007108:Immune Tolerance / Q000187:drug effects*; D007166:Immunosuppressive Agents / Q000494:pharmacology*; D007274:Injections, Intraperitoneal; D007928:Lethal Dose 50; D008297:Male; D008727:Methotrexate / Q000008:administration & dosage / Q000494:pharmacology; D008775:Methylprednisolone / Q000008:administration & dosage / Q000494:pharmacology; D051379:Mice; D008814:Mice, Inbred NZB; D011070:Poly I-C; D012756:Sheep / Q000276:immunology; D013154:Spleen / Q000166:cytology
D000941:Antigens; D002250:Carbon Radioisotopes; D007166:Immunosuppressive Agents; D003520:Cyclophosphamide; D001379:Azathioprine; D011070:Poly I-C; D000645:Ammonium Sulfate; D008775:Methylprednisolone; D008727:Methotrexate