Pharmacokinetics of trimethoprim-sulfamethoxazole in children.
The present report extends experience with the use of trimethoprim-sulfamethoxazole (TMP-SMX) in children aged 3 months to 10 years. The regimen was TMP (200 mg)--SMX (1000 mg)/m-2d given in two equal doses. The drug was easily administered, well tolerated and efficacious in the treatment of a variety of infections in 12 children. A steady state had been achieved by the third dose of medication and accumulation of either component during days 1 through 4 did not occur. Serum concentrations of TMP were slightly lower in children aged less than 3 years compared with those aged 3 to 6 years but the differences were small and these results are preliminary. Peak mean serum TMP concentration was highest at day 3 when it reached 1.63 mug/ml. It is concluded that this regimen may be suboptimal for some major parenchymal infections even though the therapeutic result was excellent in most children.
D000284:Administration, Oral; D000367:Age Factors; D001424:Bacterial Infections / Q000188:drug therapy*; D002648:Child; D002675:Child, Preschool; D004338:Drug Combinations; D004341:Drug Evaluation; D004653:Empyema / Q000188:drug therapy; D004755:Enterobacteriaceae / Q000187:drug effects; D004926:Escherichia coli / Q000187:drug effects; D005260:Female; D006193:Haemophilus influenzae / Q000187:drug effects; D006801:Humans; D007223:Infant; D008297:Male; D008826:Microbial Sensitivity Tests; D010019:Osteomyelitis / Q000188:drug therapy; D011010:Pneumocystis / Q000187:drug effects; D011014:Pneumonia / Q000188:drug therapy; D011511:Proteus / Q000187:drug effects; D012475:Salmonella / Q000187:drug effects; D018805:Sepsis / Q000188:drug therapy; D012706:Serratia marcescens / Q000187:drug effects; D013291:Streptococcus / Q000187:drug effects; D013420:Sulfamethoxazole / Q000008:administration & dosage / Q000097:blood / Q000378:metabolism*; D014295:Trimethoprim / Q000008:administration & dosage / Q000097:blood / Q000378:metabolism*; D014552:Urinary Tract Infections; D014556:Urine / Q000032:analysis
D004338:Drug Combinations; D014295:Trimethoprim; D013420:Sulfamethoxazole