Nonsterilizing immunity in avian malaria: an antibody-independent phenomenon.
Agammaglobulinemic chickens died with fulminating parasitemias following infection with P. gallinaceum. When rescued from otherwise fatal infection by means of chloroquine therapy, B-cell deficient chickens resisted challenge infection with the same parasite. The data suggest that nonsterilizing immunity to malaria in chickens is B-cell independent.
D000361:Agammaglobulinemia / Q000139:chemically induced; D000818:Animals; D001402:B-Lymphocytes / Q000276:immunology*; D002060:Bursa of Fabricius / Q000276:immunology; D002645:Chickens; D002738:Chloroquine / Q000627:therapeutic use; D008289:Malaria, Avian / Q000188:drug therapy / Q000276:immunology*; D010961:Plasmodium / Q000254:growth & development / Q000276:immunology
D002738:Chloroquine