[Animal experiments on influencing ischemic myocardial damage following temporary coronary artery ligation].
Ischemic myocardial damage produced by temporary coronary artery occlusion of 60 min duration is diminished by beta-sympathicolytic acting TrasicorR (3 mg per kg) and osmotically cell-dehydrating Manitol (1 g per kg). Trasylol, a proteinases inhibiting substance, caused a favourable effect at very high doses (100 000 DIE per kg) only. The extent and irreversibility of myocardial ischemic damage was determined by experiments of 180 min duration by intravital fluorochromatisation with acrine orange, determination of hydrogen ion concentration at frozen section of heart muscle with pH-indicatorpaper and enzymehistochemical and histochemical methods.
D000818:Animals; D007611:Aprotinin / Q000627:therapeutic use; D009202:Cardiomyopathies / Q000188:drug therapy*; D002415:Cats; D003326:Coronary Circulation; D003331:Coronary Vessels / Q000601:surgery; D007511:Ischemia / Q000188:drug therapy* / Q000209:etiology; D008026:Ligation; D008353:Mannitol / Q000627:therapeutic use; D010096:Oxprenolol / Q000627:therapeutic use
D008353:Mannitol; D010096:Oxprenolol; D007611:Aprotinin
Tierexperimentelle Untersuchungen zur Beeinflussung der ischämischen Schädigung im Myokard nach temporärer Koronararterienunterbindung