title: Strain-specific difference that affects the inhibition of division of Escherichia coli filaments by chloramphenicol.
abstract: The Escherichia coli mutations ts1882 and ts2158 cause temperature-sensitive septum formation and result in growth of cells as long, multinucleate, nonseptate filaments at 42 C. When filaments are transferred to 28 C, they divide into short cells. Chloramphenicol, when added to cultures of filaments at the time of temperature reduction. Inhibited division of filaments when these temperature-sensitive mutations were present in the K-12 strain AB1157. However, when the ts1882 and ts2158 mutations were present in another k-12 strain, UTH4113, filaments of these strains divided in the presence of chloramphenicol.
mesh_terms: D001426:Bacterial Proteins / Q000096:biosynthesis; D001433:Bacteriolysis; D002455:Cell Division / Q000187:drug effects; D002701:Chloramphenicol / Q000494:pharmacology*; D004926:Escherichia coli / Q000187:drug effects / Q000254:growth & development*; D005796:Genes; D009154:Mutation; D013045:Species Specificity; D013696:Temperature; D013997:Time Factors
chemical_list: D001426:Bacterial Proteins; D002701:Chloramphenicol