title: Human thymus-derived rosette-forming cells and immunologic diseases.
abstract: This paper describes some studies done on the human lymphocytes that bind to normal sheep red blood cells in a rosette formation. On the basis of human fetal studies and investigations of markers for B cells, it is demonstrated that rosette-forming cells are valid markers for T cells. These cells were looked at in various immunologic diseases. A modification of the basic technic, one that detects subpopulations of lymphocytes, was mainly used. Results correlate closely with the cellular immune status of the patient.
mesh_terms: D000361:Agammaglobulinemia / Q000276:immunology; D000818:Animals; D000946:Antigens, Fungal; D001665:Binding Sites; D001853:Bone Marrow / Q000276:immunology; D001854:Bone Marrow Cells; D002179:Candidiasis, Cutaneous; D002469:Cell Separation; D003165:Complement System Proteins; D004912:Erythrocytes / Q000276:immunology; D005312:Fetal Blood; D005865:Gestational Age; D006801:Humans; D007104:Immune Adherence Reaction; D007111:Immunity, Cellular; D007153:Immunologic Deficiency Syndromes / Q000276:immunology; D008099:Liver / Q000166:cytology; D008212:Lymphocyte Depletion; D008263:Macrophage Migration-Inhibitory Factors / Q000096:biosynthesis; D010587:Phagocytosis; D012756:Sheep / Q000276:immunology; D013154:Spleen / Q000166:cytology; D013601:T-Lymphocytes / Q000276:immunology*; D013950:Thymus Gland / Q000166:cytology; D014165:Transfer Factor / Q000627:therapeutic use; D014923:Wiskott-Aldrich Syndrome / Q000276:immunology
chemical_list: D000946:Antigens, Fungal; D008263:Macrophage Migration-Inhibitory Factors; D014165:Transfer Factor; D003165:Complement System Proteins