title: Azulene analogs of pharmacological agents III: acute toxicity and local anesthetic activity of azulylamides and azulenecarboxamides.
abstract: This paper describes the acute toxicity of two azulylamides and six azulenecarboxamides and the nerve conduction-inhibiting properties of some of these compounds. The azulene derivatives are compared to their benzenoid prototypes, lidocaine and procainamide, as part of a continuing investigation of the biological properties of nonbenzenoid aromatic compounds.
mesh_terms: D000081:Acetamides / Q000494:pharmacology; D000200:Action Potentials / Q000187:drug effects; D000577:Amides / Q000494:pharmacology* / Q000633:toxicity; D000779:Anesthetics, Local; D000818:Animals; D003508:Cycloheptanes / Q000494:pharmacology* / Q000633:toxicity; D003517:Cyclopentanes / Q000494:pharmacology / Q000633:toxicity; D004305:Dose-Response Relationship, Drug; D004558:Electric Stimulation; D066298:In Vitro Techniques; D007700:Kinetics; D007928:Lethal Dose 50; D008012:Lidocaine / Q000494:pharmacology; D009431:Neural Conduction / Q000187:drug effects; D009574:Nitro Compounds / Q000494:pharmacology; D011342:Procainamide / Q000494:pharmacology; D011894:Rana pipiens; D012119:Respiration / Q000187:drug effects; D012584:Sciatic Nerve / Q000187:drug effects
chemical_list: D000081:Acetamides; D000577:Amides; D000779:Anesthetics, Local; D003508:Cycloheptanes; D003517:Cyclopentanes; D009574:Nitro Compounds; D008012:Lidocaine; D011342:Procainamide