Ageing and autoimmunity.
A total of 483 healthy persons from Czechoslovakia, divided into three age groups (below 40, 41-60 and above 61 years) were examined for eight types of autoantibodies (antibodies to epithelial cells and to colloid of thyroid gland, parietal cell antibodies, antibody to intersititial duct cells of parotis and to adrenal cells, anti-nuclear and anti-mitochondrial antibodies, intrinsic factor antibodies). A significantly increased occurrence was observed in the oldest age group, the results being more manifest in women. A conspicious increase was seen particularly in the thyroid antibodies. The results correspond to those of other authors from different geographic areas.
D000311:Adrenal Glands / Q000276:immunology; D000328:Adult; D000367:Age Factors; D000368:Aged; D000375:Aging; D000974:Antibodies, Antinuclear; D000918:Antibody Specificity; D001323:Autoantibodies / Q000032:analysis*; D004847:Epithelial Cells; D004848:Epithelium / Q000276:immunology; D006801:Humans; D007437:Intrinsic Factor; D008875:Middle Aged; D008928:Mitochondria / Q000276:immunology; D010306:Parotid Gland / Q000276:immunology; D013961:Thyroid Gland / Q000276:immunology
D000974:Antibodies, Antinuclear; D001323:Autoantibodies; D007437:Intrinsic Factor