Subpopulations of B lymphocytes and the carriage of immunological memory.
Thoracic duct lymphocytes from rats primed with DNP-BGG confer on irradiated, syngeneic recipients the ability to mount a large, IgG anti-DNP response after challenge with the immunizing conjugate. An analysis of this adoptive response lead to the following conclusions. the B memory cells which generate the IgG response carry IgG on their surface and are present in a subpopulation amounting to less than l0% of all B cells in thoracic duct lymph. The view that memory cells carry exclusively IgD is untenable. The majority of B lymphocytes in thoracic duct lymph are recirculating cells which carry surface IgM...
D000818:Animals; D000917:Antibody Formation; D001402:B-Lymphocytes / Q000276:immunology*; D002469:Cell Separation; D003176:Complement C3 / Q000378:metabolism; D004136:Dinitrobenzenes / Q000276:immunology; D007104:Immune Adherence Reaction; D007074:Immunoglobulin G; D007156:Immunologic Memory; D051381:Rats; D011947:Receptors, Antigen, B-Cell / Q000032:analysis; D013897:Thoracic Duct / Q000166:cytology
D003176:Complement C3; D004136:Dinitrobenzenes; D007074:Immunoglobulin G; D011947:Receptors, Antigen, B-Cell