Subconjunctival injection of antilymphocyte serum during corneal hypersensitivity to heterologous alubmin.
Thirty-two rabbits were immunized by subcutaneous human serum albumin in Freund's adjuvant and challenged after four weeks by intracorneal injection in both eyes. On a random and blind basis, one of the eyes in each animal received three consecutive injections of antilymphocyte serum obtained from rats and the other eye the same dose of normal rat serum. Statistical analysis of results showed no significant difference between both treatments. Two eyes treated with antilymphocyte serum had limbal necrosis with uveal prolapse.
D000818:Animals; D000961:Antilymphocyte Serum / Q000494:pharmacology*; D003315:Cornea / Q000187:drug effects / Q000276:immunology*; D005620:Freund's Adjuvant; D006801:Humans; D006968:Hypersensitivity, Delayed; D007165:Immunosuppression Therapy; D007634:Keratitis; D011817:Rabbits; D051381:Rats; D011919:Rats, Inbred Strains / Q000276:immunology; D012709:Serum Albumin / Q000037:antagonists & inhibitors / Q000276:immunology
D000961:Antilymphocyte Serum; D012709:Serum Albumin; D005620:Freund's Adjuvant