Role of membrane structures in B-lymphocyte activation. The effect of binding anti-immunoglobulin, aggregated IgG and immune complexes.
It is shown that the binding of bivalent anti-immunoglobulin preparations to the surface immunoglobulin of murine B lymphocytes as well as the binding of aggregates of IgG or immune complexes does not lead to detectable increase in cell division in microcultures. Treating lymphocytes with immune complexes and aggregated IgG does not abolish the subsequent mitogenic response induced by LPS. The background mitosis observed in culture is inhibited with anti-immunoglobulin antibodies.
D000818:Animals; D000888:Antibodies, Anti-Idiotypic; D000936:Antigen-Antibody Complex; D001402:B-Lymphocytes / Q000276:immunology* / Q000378:metabolism; D005293:Ferritins / Q000276:immunology; D007106:Immune Sera; D007140:Immunoglobulin Fab Fragments; D007141:Immunoglobulin Fc Fragments; D007074:Immunoglobulin G; D008070:Lipopolysaccharides / Q000276:immunology; D051379:Mice; D008938:Mitosis; D011947:Receptors, Antigen, B-Cell; D013936:Thymidine / Q000378:metabolism
D000888:Antibodies, Anti-Idiotypic; D000936:Antigen-Antibody Complex; D007106:Immune Sera; D007140:Immunoglobulin Fab Fragments; D007141:Immunoglobulin Fc Fragments; D007074:Immunoglobulin G; D008070:Lipopolysaccharides; D011947:Receptors, Antigen, B-Cell; D005293:Ferritins; D013936:Thymidine