title: A temperature sensitive nonsense mutation affecting the synthesis of a major protein of Escherichia coli K12.
abstract: A temperature sensitive nonsense (TSN) mutant of E. coli K12 has been isolated in which a major bacterial protein is not synthesized at 42 degrees C. This protein is found in the parental strain at 42 degrees C and in cells rendered temperature resistant due to the insertion of a number of different nonsense suppressors or the normal allele of the mutant locus.
mesh_terms: D000483:Alleles; D001426:Bacterial Proteins / Q000096:biosynthesis*; D003090:Coliphages; D004926:Escherichia coli; D005827:Genetics, Microbial; D006358:Hot Temperature; D009154:Mutation; D013489:Suppression, Genetic; D013696:Temperature
chemical_list: D001426:Bacterial Proteins