Experimental murine leprosy. 3. Early local reaction to mycobacterium lepraemurium in C3H and C57/BL mice.
M. lepraemurium was injected subcutaneously into two inbred strains of mice, C3H and C57/BL, in order to study the local reaction at various time intervals. Within 6 hours an acute inflammatory reaction developed at the site of injection. In the course of the following days it was replaced by a mononuclear infiltrate. The influx of mononuclear cells appeared to be somewhat greater in C57/BL than in C3H mice. Apart from this, little difference was observed between the two strains until at 4 weeks when a vigorous granulomatous reaction developed in the C57/BL strain. This reaction apparently arrested further local spread of the infection. The histological appearance of the inflitrate indicated that a delayed hypersensitivity reaction was taking place. No signs of such reaction was observed in the C3H strain.
D000208:Acute Disease; D000818:Animals; D004487:Edema; D005260:Female; D006968:Hypersensitivity, Delayed; D007962:Leukocytes / Q000648:ultrastructure; D008264:Macrophages; D051379:Mice; D008809:Mice, Inbred C3H; D008810:Mice, Inbred C57BL; D009164:Mycobacterium Infections / Q000473:pathology*; D009167:Mycobacterium lepraemurium / Q000472:pathogenicity*; D009336:Necrosis; D010586:Phagocytes / Q000648:ultrastructure; D013997:Time Factors