title: B lymphocytes in primary and secondary deficiencies of humoral immunity.
abstract: The quantitative studies of B lymphocytes in peripheral blood have been performed in various forms of primary and secondary immunodeficiency disease in man. X-linked agammaglobulinemia was found to comprise two sub-types, one lacking B-cell population, the other showing low numbers of B lymphocytes. The absence of B cells in severe combined immunodeficiency was corrected by marrow transplants in 3 children. Cases of DiGeorge syndrome and lepromatous leprosy showed an absolute increase in numbers of B lymphocytes in peripheral blood, probably a compensatory mechanism in the market deficit of T-cell population and function. The reconstitution of DiGeorge syndrome by fetal thymus transplant reversed the abnormally high percentage of B lymphocytes.
mesh_terms: D000361:Agammaglobulinemia / Q000235:genetics / Q000276:immunology; D000917:Antibody Formation; D001402:B-Lymphocytes / Q000276:immunology*; D002454:Cell Differentiation; D003165:Complement System Proteins; D006801:Humans; D006942:Hypergammaglobulinemia / Q000276:immunology; D007153:Immunologic Deficiency Syndromes / Q000276:immunology*; D007918:Leprosy / Q000276:immunology; D008198:Lymph Nodes / Q000166:cytology; D008212:Lymphocyte Depletion; D008223:Lymphoma / Q000276:immunology; D010280:Parathyroid Glands / Q000002:abnormalities; D010641:Phenotype; D010950:Plasma Cells / Q000276:immunology; D011947:Receptors, Antigen, B-Cell; D013577:Syndrome; D013601:T-Lymphocytes; D013950:Thymus Gland / Q000002:abnormalities
chemical_list: D011947:Receptors, Antigen, B-Cell; D003165:Complement System Proteins