Improved HL-A typing of cadaveric renal donors. I. Quantitation of HL-A gene dosage.
A quantitative microabsorption technique has been used to determine a gene dosage effect on HL-A. This allows homozygosity or heterozygosity of HL-A antigens to be determined prospectively in cadaver donors of renal allografts where less than four antigens were detected by standard lymphocytotoxicity. This in turn provides more precise matching of donor and recipient.
D002102:Cadaver; D003601:Cytotoxicity Tests, Immunologic; D005838:Genotype; D006680:HLA Antigens; D006649:Histocompatibility Antigens; D006650:Histocompatibility Testing; D006801:Humans; D007106:Immune Sera; D016030:Kidney Transplantation; D008214:Lymphocytes / Q000276:immunology*; D010641:Phenotype; D014184:Transplantation, Homologous
D006680:HLA Antigens; D006649:Histocompatibility Antigens; D007106:Immune Sera