[Hemophilia A: early detection of women carriers by Laurell's quantitative immunoelectrophoresis].
Using one-stage quantitative factor VIII assay and the quantitative immunoelectrophoretic method of LAURELL a good correlation has been found between factor VII activity and protein concentration. In 80% of the known hemophilia A carriers the protein concentration was about twice as high as in normals as compared to the factor VIII activity, whereas about 20% of the known carriers have the same ratio between factor VIII protein and factor VIII activity as normals. The reliability of the test and its usefulness for the detection of hemophilia A carriers are discussed.
D000910:Antibodies, Heterophile; D000917:Antibody Formation; D005169:Factor VIII / Q000302:isolation & purification; D005260:Female; D006467:Hemophilia A / Q000235:genetics* / Q000276:immunology; D006801:Humans; D007122:Immunoelectrophoresis; D008297:Male; D014842:von Willebrand Diseases / Q000276:immunology
D000910:Antibodies, Heterophile; D005169:Factor VIII
Hämophilie A: Früherfassung der Konduktorinnen mit der quantitativen Immunelektrophorese nach Laurell