title: Oxygen plus pressure plus time: the etiology of bronchopulmonary dysplasia.
abstract: Ten infants developed the chronic pulmonary syndrome designated bronchopulmonary dysplasia, following artificial (assisted) ventilation using a volume-regulated positive-pressure respirator. Despite previous reports implicating elevated oxygen concentrations for prolonged periods of time, only two infants required more than 80% oxygen for more than 24 hours, and only one infant required 60% oxygen for more than 100 hours. "Immature" lungs when exposed to inspired oxygen concentrations over 40% for as little as three days via positive-pressure ventilation may develop bronchopulmonary dysplasia. The role of the underlying disease and the relationship with Wilson-Mikity syndrome remain uncertain.
mesh_terms: D006801:Humans; D006819:Hyaline Membrane Disease / Q000628:therapy; D007223:Infant; D007231:Infant, Newborn; D007235:Infant, Premature, Diseases / Q000628:therapy*; D008171:Lung Diseases / Q000000981:diagnostic imaging / Q000209:etiology*; D010100:Oxygen / Q000097:blood / Q000633:toxicity*; D011175:Positive-Pressure Respiration / Q000009:adverse effects*; D011312:Pressure; D011859:Radiography; D012127:Respiratory Distress Syndrome, Newborn / Q000628:therapy*; D013997:Time Factors
chemical_list: D010100:Oxygen