title: In vitro immunological studies on east african cancer patients. III. Spontaneous rosette formation by cells from Burkitt lymphoma biopsies.
abstract: Spontaneous rosette formation was observed in eight out of nine Burkitt lymphoma biopsies. These were examined fresh and/or after culture in vitro for up to 48 h. The percentage of rosettes varied from 3.7% to 38%. There was a tendency for the percentage of rosettes to increase with time in tissue culture. It is suggested that the rosette-forming cells are T-lymphocytes infiltrating the tumour and functioning as a host defence mechanism against the proliferating tumour cells.
mesh_terms: D000351:Africa, Eastern; D001706:Biopsy; D002051:Burkitt Lymphoma / Q000097:blood / Q000276:immunology* / Q000473:pathology; D002478:Cells, Cultured; D003470:Culture Media; D006801:Humans; D007104:Immune Adherence Reaction; D007111:Immunity, Cellular; D066298:In Vitro Techniques; D013601:T-Lymphocytes / Q000276:immunology*; D013997:Time Factors
chemical_list: D003470:Culture Media