Disseminated mycobacterium kansasii infection presenting as cellulitis in a recipient of a renal homograft.
A recipient of a renal homograft developed disseminated infection caused by Mycobacterium kansaii. He initially presented with cellulitis and abscesses in one foot, and was thought to have a pyogenic bacterial infection. The daily administration of prednisone and azathioprine appears to have prevented the typical cell-mediated granulomatous reaction to mycobacterial infection and to have contributed to the patient's atypical inflammatory response. A switch to alternate-day prednisone combined with antimycobacterial medication resulted in rapid healing without rejection of the homograft.
D000328:Adult; D001379:Azathioprine / Q000627:therapeutic use; D001706:Biopsy; D002481:Cellulitis / Q000175:diagnosis*; D005528:Foot / Q000473:pathology; D005534:Foot Diseases / Q000175:diagnosis*; D006801:Humans; D007111:Immunity, Cellular / Q000187:drug effects; D007165:Immunosuppression Therapy; D016030:Kidney Transplantation; D008297:Male; D009164:Mycobacterium Infections / Q000175:diagnosis* / Q000276:immunology; D011241:Prednisone / Q000627:therapeutic use; D014181:Transplantation Immunology; D014184:Transplantation, Homologous
D001379:Azathioprine; D011241:Prednisone