Long-range effects of Ivalon sponge containing isobutyl cyanoacrylates on rat tissue. A quantitative planimetric study.
This study on seventy rats was undertaken to determine the long-range effects of Ivalon sponge containing isobutyl cyanoacrylates (IBC). Histologic examination revealed that IBC sponge was well tolerated by the connective tissue. IBC sponge was most effective during the first 2 weeks of healing. At observation periods of 1 and 2 weeks, the percentage values for connective tissue formed in IBC-treated animals were 2.02 and 1.58 times higher than those in the untreated animals.
D000818:Animals; D001458:Bandages / Q000009:adverse effects; D002015:Bucrylate / Q000009:adverse effects / Q000494:pharmacology*; D003238:Connective Tissue / Q000098:blood supply / Q000187:drug effects / Q000378:metabolism*; D003487:Cyanoacrylates / Q000494:pharmacology*; D005549:Foreign-Body Reaction / Q000209:etiology; D007249:Inflammation / Q000209:etiology; D008264:Macrophages; D008297:Male; D010537:Peritoneum / Q000187:drug effects / Q000378:metabolism; D051381:Rats; D013525:Surgical Instruments / Q000009:adverse effects; D014014:Tissue Adhesives / Q000494:pharmacology*
D003487:Cyanoacrylates; D014014:Tissue Adhesives; D002015:Bucrylate