Genetic control of the murine cell-mediated immune response in vivo. I. H-2-linked responsiveness to the terpolymer L-glutamic acid-60-L-alanine-30-L-tyrosine-10.
Various inbred and congenic strains of mice were immunized with the linear terpolymer L-glutamic acid-60-L-alanine-30-L-tyrosine-10 (GAT). Using a radioisotopic footpad assay to measure cell-mediated immunity in vivo, mice with H-2-a, H-2-b, H-2-d, and H-2-k histocompatibility alleles showed a positive reaction, whereas mice with H-2p and H-2-s alleles failed to respond. The ability of "responder" lymphocytes to show an immune response resides in the thymus-derived (T) lymphocyte population. Unfractionated spleen cells from H-2-q nonresponder mice, on transfer, showed no reactivity, whereas T-cell-enriched preparations were active.
D000409:Alanine; D000483:Alleles; D000818:Animals; D000917:Antibody Formation; D001402:B-Lymphocytes / Q000276:immunology / Q000637:transplantation*; D002452:Cell Count; D002478:Cells, Cultured; D005260:Female; D008040:Genetic Linkage; D005973:Glutamine; D006648:Histocompatibility; D006801:Humans; D007106:Immune Sera; D007111:Immunity, Cellular; D007112:Immunity, Maternally-Acquired; D007114:Immunization; D008213:Lymphocyte Activation; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D013154:Spleen; D013601:T-Lymphocytes / Q000276:immunology / Q000637:transplantation*; D014184:Transplantation, Homologous; D014443:Tyrosine
D007106:Immune Sera; D005973:Glutamine; D014443:Tyrosine; D000409:Alanine