Effects of ethanol on protein synthesis.
Cardiac: Cardiac protein synthesis is influenced by the state of nutrition with reduction of cardiac size in starvation. Ethanol per se may not affect this synthesis directly, but the metabolite of ethanol, acetaldehyde, profoundly decreases normal protein synthesis in the heart in vitro. The interference with the synthetic process may play a role in the ultimate cardiomyopathies of malnutrition and alcoholism. Hepatic: In vivo albumin synthesis is sensitive to environment, oncotic pressure, normal balance, nutrition, as well as toxins and state of health. Thus, to study the acute effects of alcohol alone, it was necessary to employ the isolated perfused liver. Fasting reduced albumin synthesis 50%, with loss of RNA and a disaggregation of the endoplasmic membrane bound polysome. Tryptophan, arginine and ornithine added to the perfusate at a final concentration of 10 mM reversed these findings. Alcohol likewise reduced albumin synthesis; disaggregates the bound polysome without a marked loss of RNA. Ornithine, arginine and tryptophan are able to reverse this loss in albumin synthesizing capacity. The combination of fasting and alcohol, while not lowering albumin synthesis below that seen with either stress alone, prevents the recovery from either stress.
D000079:Acetaldehyde / Q000494:pharmacology; D000418:Albumins / Q000096:biosynthesis; D000596:Amino Acids / Q000378:metabolism; D000818:Animals; D004032:Diet; D004285:Dogs; D000431:Ethanol / Q000494:pharmacology*; D006168:Guinea Pigs; D006321:Heart / Q000187:drug effects; D008099:Liver / Q000187:drug effects / Q000378:metabolism; D009124:Muscle Proteins / Q000096:biosynthesis; D009206:Myocardium / Q000378:metabolism; D010477:Perfusion; D011132:Polyribosomes / Q000378:metabolism; D011433:Propranolol / Q000494:pharmacology; D014176:Protein Biosynthesis / Q000187:drug effects*
D000418:Albumins; D000596:Amino Acids; D009124:Muscle Proteins; D000431:Ethanol; D011433:Propranolol; D000079:Acetaldehyde