title: Chronic pulmonary disease in neonates with assisted ventilation.
abstract: Chronic lung disease in the form of stage III or IV bronchopulmonary dysplasia (BPD) was found to occur among nine of 188 infants receiving intermittent positive-pressure ventilation for respiratory insufficiency. None occurred in infants ventilated with a mask alone. The duration of endotracheal intubation was not significantly longer in patients developing BPD; however, the duration of exposure to inspired oxygen greater than 60 percent was significantly longer in that group (mean, 141 hours). A previously undescribed form of chronic lung disease was found to occur among nine of 150 infants ventilated because of underlying idiopathic respiratory distress syndrome. A radiographic appearance of diffuse haziness with loss of identifiable lung markings occurred at 5 to 15 days of age and was not associated with clinical signs or symptoms or increased oxygen needs. These changes disappeared in one to five days.
mesh_terms: D001724:Birth Weight; D002908:Chronic Disease; D005260:Female; D005865:Gestational Age; D006801:Humans; D007231:Infant, Newborn; D007232:Infant, Newborn, Diseases / Q000209:etiology*; D007384:Intermittent Positive-Pressure Breathing / Q000009:adverse effects*; D007442:Intubation, Intratracheal / Q000009:adverse effects; D008171:Lung Diseases / Q000000981:diagnostic imaging / Q000209:etiology* / Q000401:mortality; D010102:Oxygen Inhalation Therapy / Q000009:adverse effects; D011014:Pneumonia / Q000209:etiology; D011175:Positive-Pressure Respiration / Q000009:adverse effects*; D011247:Pregnancy; D011859:Radiography; D013997:Time Factors; D014135:Tracheal Stenosis / Q000209:etiology