title: Antimalarial compounds. XIV. New derivatives of 2-bromo-N,N-bis-(diethylaminoethyl)-4,5-dimethoxyanaline (RC 12).
abstract: The molecule of RC 12 which was found previously to exhibit antimalarial activity has been modified, by replacing groups in positions 1 and 2 by NHAr, S-Ar, NO2, sulfonamido and other substituents. The new derivatives (Table 1) were tested for toxicity and antimalarial activity agains Plasmodium berghei in mice (Table 2).
mesh_terms: D000284:Administration, Oral; D000818:Animals; D000962:Antimalarials / Q000138:chemical synthesis* / Q000627:therapeutic use / Q000633:toxicity; D002396:Catechols / Q000138:chemical synthesis* / Q000627:therapeutic use / Q000633:toxicity; D005029:Ethylenediamines / Q000138:chemical synthesis* / Q000627:therapeutic use / Q000633:toxicity; D007279:Injections, Subcutaneous; D007928:Lethal Dose 50; D008288:Malaria / Q000188:drug therapy; D051379:Mice; D010962:Plasmodium berghei
chemical_list: D000962:Antimalarials; D002396:Catechols; D005029:Ethylenediamines; C006018:RC-12