Effect of hydrocortisone on response of human lymphocytes to galactose oxidase stimulation.
Hydrocortisone at 10(-4)M concentration could inhibit the response of human lymphocytes to galactose oxidase stimulation. Removal of the hydrocortisone after 4 h of culture did not reverse this inhibition. On the other hand, removal of monocytes greatly enhanced it, so that it could be observed at 10(-6)M concentration. Next, tonsil cells were separated into two fractions relatively rich in either T or B cells. Both fractions could respond to galactose oxidase and the response could be inhibited by hydrocortisone.
D000429:Alcohol Oxidoreductases / Q000494:pharmacology*; D001402:B-Lymphocytes / Q000276:immunology; D004306:Dose-Response Relationship, Immunologic; D005692:Galactose Oxidase / Q000494:pharmacology*; D006801:Humans; D006854:Hydrocortisone / Q000494:pharmacology*; D008213:Lymphocyte Activation / Q000187:drug effects; D009000:Monocytes / Q000276:immunology; D009439:Neuraminidase / Q000494:pharmacology; D013601:T-Lymphocytes / Q000276:immunology; D013997:Time Factors
D000429:Alcohol Oxidoreductases; D005692:Galactose Oxidase; D009439:Neuraminidase; D006854:Hydrocortisone