Potentiating effect of fetal thymus on fetal liver cells for the promotion of recovery from the radiation injury in murine allogenic radiation chimeras or a little bit of thymus goes a long, long way.
Lethally irradiated CBA (H-2k) mice were treated with small numbers of liver cells from strain-A (H-2a) fetal donors. Recovery from the radiation injury was dependent upon the dose of liver cells administered. Giving very small numbers of fetal thymus cells, in addition to liver cells, had a highly significant and salutary effect on survival. The results suggest that clinical transplantation of liver cells from a single fetus might succeed if thymus cells are added.
D000818:Animals; D005260:Female; D005333:Fetus / Q000276:immunology; D008099:Liver / Q000166:cytology; D016031:Liver Transplantation; D051379:Mice; D008805:Mice, Inbred A; D008808:Mice, Inbred CBA; D011828:Radiation Chimera; D011833:Radiation Injuries, Experimental / Q000628:therapy; D013950:Thymus Gland / Q000166:cytology / Q000637:transplantation*