title: Natriuretic hormone.
abstract: The factors that control sodium excretion have been the subject of considerable work in recent years. The natriuresis that follows expansion of the extracellular fluid volume is mediated to a large extent by inhibition of tubular sodium reabsorption. Of the several mechanisms proposed to explain this inhibition, considerable interest has followed the suggestion that a humoral substance is released into the blood stream in response to volume expansion. The present article reviews the evidence for and against the existence of such a humoral substance (natriuretic hormone). It also discusses its proposed chemical nature and its possible site of origin in the organism as well as its mode of action.
mesh_terms: D000311:Adrenal Glands / Q000502:physiology; D000450:Aldosterone / Q000502:physiology; D000818:Animals; D001001:Anura; D001681:Biological Assay; D001810:Blood Volume; D001921:Brain / Q000502:physiology; D002415:Cats; D004285:Dogs; D006041:Goats; D006728:Hormones / Q000032:analysis / Q000096:biosynthesis; D066298:In Vitro Techniques; D007668:Kidney / Q000502:physiology; D009318:Natriuresis; D051381:Rats; D012039:Regional Blood Flow; D012964:Sodium / Q000097:blood; D014511:Uremia / Q000097:blood
chemical_list: D006728:Hormones; D000450:Aldosterone; D012964:Sodium