Behavioral supersensitivity to 5-hydroxytryptophan induced by chronic methysergide pretreatment.
The administration of 5-hydroxytryptophan to intact guinea pigs results in rhythmic myoclonic behavior. This behavior is blocked acutely by methysergide, but is intensified in animals chronically pretreated with methysergide. Brain serotonin concentrations of guinea pigs pretreated with methysergide did not differ from saline-treated animals. These results are compatible with the hypothesis that prolonged methysergide administration can result in pharmacologically-induced denervation hypersensitivity at central serotonin receptors.
D006916:5-Hydroxytryptophan / Q000494:pharmacology*; D000818:Animals; D001519:Behavior; D001923:Brain Chemistry / Q000187:drug effects; D004357:Drug Synergism; D006168:Guinea Pigs; D006801:Humans; D008297:Male; D008784:Methysergide / Q000494:pharmacology*; D009207:Myoclonus / Q000139:chemically induced* / Q000378:metabolism; D011955:Receptors, Drug / Q000187:drug effects; D012640:Seizures / Q000139:chemically induced; D012701:Serotonin / Q000378:metabolism*; D013239:Stereotyped Behavior / Q000187:drug effects
D011955:Receptors, Drug; D012701:Serotonin; D006916:5-Hydroxytryptophan; D008784:Methysergide