Evidence for the D-cell of the pancreas secreting somatostatin.
By immunofluorescence, somatostatin-, glucagon- and insulin-containing cells are localized in serial sections of the pigeon pancreas. The distribution of the somatostatin immunofluorescent-cells corresponds to that of the D-cells (A1-cells), which are particularly numerous in this animal species. This observation, coupled with the finding of D, A and B-cells at the ultrastructural level, indicates that the D-cell is responsible for the secretion of somatostatin.
D000818:Animals; D010856:Columbidae; D005934:Glucagon / Q000276:immunology / Q000378:metabolism; D007328:Insulin / Q000276:immunology / Q000378:metabolism; D000078790:Insulin Secretion; D007515:Islets of Langerhans / Q000166:cytology* / Q000648:ultrastructure; D008854:Microscopy, Electron; D008856:Microscopy, Fluorescence; D013004:Somatostatin / Q000276:immunology / Q000378:metabolism*
D007328:Insulin; D013004:Somatostatin; D005934:Glucagon