Suicide with aprindine and digoxin.
A 48 year old man with severe coronary artery disease died approximately 33 hours after swallowing unknown amounts of aprindine, digoxin, furosemide, acenocoumarol, flurazepam, nitrazepam and lorazepam. Blood analysis carried out 40 min. before death showed no hydric or ionic imbalance; blood gases were normal. Serum digoxin concentration was 3.9 ng/ml; plasma concentration of aprindine was 2.5 mug/ml and plasma concentration of desethylaprindine was 386 ng/ml. Patient was profoundly comatose, hypotensive, and the electrocardiogram showed broad and bizarre QRS complexes; patient ultimately died in irreversible secondary ventricular fibrillation and asystole. Aprindine probably played a decisive role in the fatal outcome of this complex drug intoxication.
D001073:Aprindine / Q000506:poisoning*; D001569:Benzodiazepines; D004077:Digoxin / Q000506:poisoning*; D004562:Electrocardiography; D006327:Heart Block / Q000139:chemically induced; D006329:Heart Conduction System / Q000187:drug effects / Q000503:physiopathology; D006801:Humans; D007192:Indenes / Q000506:poisoning*; D008297:Male; D008875:Middle Aged; D013405:Suicide
D007192:Indenes; D001569:Benzodiazepines; D001073:Aprindine; D004077:Digoxin