title: Enchancement of deficient pituitary response to luteinizing hormone releasing hormone in patients with primary amenorrhea.
abstract: Although the absence of pituitary response to the luteinizing hormone releasing hormone (LHRH) test has been considered proof of a lesion primarily localized at the pituitary level, the possibility exists that an absent pituitary response may represent only the effect of a chronic deficiency of hypothalamic secretion. To verify this hypothesis, 4 patients with primary amenorrhea, hypogonadotropic hypogonadism, and deficient or absent responses to a 25 mug LHRH rapid IV test were treated with 400 mug LHRH infused in 7 hours during each of 3 successive days. The finding that patients with deficient LH responses to a rapid LHRH test became normally responsive to a second equivalent test after a slow and prolonged treatment with the decapeptide suggests that, in these patients, besides a lesion at the pituitary level, a primary defect at the hypothalamic or higher centers may also be suspected.
mesh_terms: D000293:Adolescent; D000328:Adult; D000568:Amenorrhea / Q000378:metabolism / Q000503:physiopathology*; D004967:Estrogens / Q000652:urine; D005260:Female; D005640:Follicle Stimulating Hormone / Q000097:blood / Q000378:metabolism; D007987:Gonadotropin-Releasing Hormone / Q000008:administration & dosage; D006801:Humans; D007006:Hypogonadism / Q000378:metabolism / Q000503:physiopathology; D007263:Infusions, Parenteral; D007275:Injections, Intravenous; D007986:Luteinizing Hormone / Q000097:blood; D010902:Pituitary Gland / Q000503:physiopathology*
chemical_list: D004967:Estrogens; D007987:Gonadotropin-Releasing Hormone; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone