Reticulum cell sarcoma: an effector cell in antibody-dependent cell-mediated immunity.
A transplantable, murine reticulum cell sarcoma is described which exhibits the cytologic, adherence, and phagocytic properties of macrophages. It forms specific rosettes with erythrocytes in the presence of the corresponding anti-serum. The ascites cells mediate antibody-dependent cellular immunity as assayed by release of radioactivity from 51Cr-labeled erythrocytes. The contribution of contaminating host cells in the cytotoxic reaction was ruled out by growing the tumor in F1 mice and removing the host cells by anti-H2 serum and complement. The tumor cells have receptors for IgG2a and IgG2b immunoglobulins. The availability of a pure population of effector cells in the immune system allows study of the biochemical processes pursuant to lysis of foreign cells.
D000818:Animals; D000937:Antigen-Antibody Reactions; D001666:Binding Sites, Antibody; D002462:Cell Membrane / Q000276:immunology; D002860:Chromium Radioisotopes; D003601:Cytotoxicity Tests, Immunologic; D004912:Erythrocytes / Q000276:immunology; D007104:Immune Adherence Reaction; D007111:Immunity, Cellular; D007074:Immunoglobulin G; D008228:Lymphoma, Non-Hodgkin / Q000276:immunology*; D008264:Macrophages / Q000276:immunology; D051379:Mice; D009194:Myeloma Proteins; D009368:Neoplasm Transplantation; D009374:Neoplasms, Experimental / Q000276:immunology; D010527:Perissodactyla / Q000276:immunology; D010587:Phagocytosis; D012756:Sheep / Q000276:immunology; D014184:Transplantation, Homologous
D002860:Chromium Radioisotopes; D007074:Immunoglobulin G; D009194:Myeloma Proteins