[Clinical investigations of the steroid anaesthetic agent CT-1341 (Althesin) (Cardiovascular and respiratory effects)].
The new steroid anaesthetic CT-1341 (Althesin) has been used as an induction agent in dose of 0.07 ml/kg body weight. Following injection, stage 1 anaesthesia is reached in an average of 30 sec with a clinical duration of between 12 and 20 min with total recovery, supported by a normal pre-anaesthetic EEG tracing, in 40 to 50 min. The respiratory depression following injection in characterized by a short period of apnea followed by an increased respiratory rate and a diminished tidal volume; there is a decrease of the pO2 of about 15%, but the pCO2 and pH values do not show significant variations. Concerning its action on the cardiovascular system, there was found an increase of heart rate (+14%), a decrease of both systolic (-19%) and diastolic pressures (minus decrease of both systolic (-19%) and diastolic pressure (-13.5%), central venous pressure and the peripheral vascular resistance (-14%) with hardly any change in the pulmonary artery pressure.
D000328:Adult; D000368:Aged; D000777:Anesthetics / Q000494:pharmacology*; D001794:Blood Pressure / Q000187:drug effects; D002245:Carbon Dioxide / Q000097:blood; D002496:Central Venous Pressure / Q000187:drug effects; D002986:Clinical Trials as Topic; D004338:Drug Combinations; D004562:Electrocardiography; D004569:Electroencephalography; D005260:Female; D006439:Hemodynamics / Q000187:drug effects*; D006801:Humans; D006914:Hydroxysteroids / Q000494:pharmacology; D007275:Injections, Intravenous; D007664:Ketosteroids / Q000494:pharmacology; D008297:Male; D008875:Middle Aged; D010100:Oxygen / Q000097:blood; D010313:Partial Pressure; D011278:Pregnanes / Q000494:pharmacology*; D011651:Pulmonary Artery; D012039:Regional Blood Flow / Q000187:drug effects; D012119:Respiration / Q000187:drug effects*; D013997:Time Factors
D000777:Anesthetics; D004338:Drug Combinations; D006914:Hydroxysteroids; D007664:Ketosteroids; D011278:Pregnanes; D002245:Carbon Dioxide; D010100:Oxygen
Klinische Untersuchungen des Steroid-Anaestheticums CT-1341 (Althesin) (Kardiovasculäre und respiratorische Wirkungen)