[Plasminogen activator and other trypsin-like proteases in the uterus wall and their participation on the tissue bleeding (author's transl)].
In the myometrium and endometrium a content of plasminogen activator and non-specific trypsin-like proteases was determined. It was ascertained that there was a higher level of plasminogen activator in the endometrium during the menstruation in the contrary to the first and second phase of the menstrual cycle and that both plasminogen activator and non-specific trypsin-like proteases were relative higher in Corpusmyometrium than those Cervixmyometrium. The proteases present in the fractions of myometriumeluate were able to split casein and partially fibrin, too. These activities were not inhibited by epsilon aminocaproic acid and aprotinin. The importance of these findings for gynaecological bleeding was suggested.
D000614:Aminocaproates / Q000494:pharmacology; D007611:Aprotinin / Q000494:pharmacology; D002364:Caseins; D002584:Cervix Uteri / Q000201:enzymology; D004717:Endometrium / Q000201:enzymology; D005260:Female; D005337:Fibrin; D005342:Fibrinolysis; D005998:Glycine; D006801:Humans; D008239:Lysine; D008598:Menstruation; D009215:Myometrium / Q000201:enzymology; D010446:Peptide Fragments; D010447:Peptide Hydrolases / Q000032:analysis*; D010960:Plasminogen Activators / Q000032:analysis*; D011480:Protease Inhibitors; D013997:Time Factors; D014106:Tosylarginine Methyl Ester; D014357:Trypsin / Q000032:analysis; D014599:Uterus / Q000201:enzymology*
D000614:Aminocaproates; D002364:Caseins; D010446:Peptide Fragments; D011480:Protease Inhibitors; D005337:Fibrin; D014106:Tosylarginine Methyl Ester; D007611:Aprotinin; D010447:Peptide Hydrolases; D010960:Plasminogen Activators; D014357:Trypsin; D008239:Lysine; D005998:Glycine
Plasminogenaktivator und andere trypsinähnliche Proteasen im Gebärmutterbewebe und ihre Teilnahme an den Gewebsblutungen