[Thymolytic activity of chlorimipramine].
Chloroimipramine in vitro on human lymphocytes stimulated by phytohaemoagglutinin at concentrations from 1 to 10 g/ml leads to mitotic block. Treatment of normal or suprarenalectomized rats with high doses of the drug administered orally leads to a reduction in the weight of the thymus. The hypothesis that chloroimipramine possibly plays a part in immunitary processes is put forward.
D000284:Administration, Oral; D000315:Adrenalectomy; D000818:Animals; D002997:Clomipramine / Q000008:administration & dosage / Q000494:pharmacology*; D003984:Dibenzazepines / Q000494:pharmacology*; D007928:Lethal Dose 50; D008938:Mitosis / Q000187:drug effects; D009929:Organ Size / Q000187:drug effects; D051381:Rats; D013601:T-Lymphocytes / Q000187:drug effects; D013950:Thymus Gland / Q000187:drug effects* / Q000276:immunology
D003984:Dibenzazepines; D002997:Clomipramine
Attivitá timolitica della cloroimipramina