title: [Clinical and epidemiological aspects of influenza chemoprophylaxis with bonaphthone].
abstract: The results of double blind clinical, phisiological, biochemical immunological and virological studies carried out in 460 normal volunteers gave sufficiently objective evaluation of safety and antiinfluenza activity of bonaphthone. The new antiviral drug is recommended for wide epidemiological trials. In epidemiological, coded and strictly controlled experiment during influenza A/England epidemic in 1973 involving 1393 persons the prophylactic effectiveness of bonaphthone was established (the index of effectiveness 2.09).
mesh_terms: D000917:Antibody Formation / Q000187:drug effects; D000998:Antiviral Agents / Q000627:therapeutic use*; D002986:Clinical Trials as Topic; D006801:Humans; D007251:Influenza, Human / Q000276:immunology / Q000517:prevention & control*; D009285:Naphthoquinones / Q000627:therapeutic use*
chemical_list: D000998:Antiviral Agents; D009285:Naphthoquinones
vernacular_title: Kliniko-épidemiologicheskie aspekty khimioprofilaktiki grippa bonaftonom