title: Spontaneous and methylcholanthrene-enhanced thyroiditis in BUF rats. I. The incidence and severity of the disease, and the genetics of susceptibility.
abstract: Virgin female Buffalo strain (BUF) rats that were treated with methylcholanthrene (MC) had a higher incidence of lymphocytic thyroiditis than untreated BUF rats. The degree of infiltration was also greater in MC-treated rats. The incidence of thyroiditis in retired breeder female BUF rats approached that found in MC-treated rats. The susceptibility to the effect of MC was not expressed in most F-1 hybrids of BUF and Lewis (LEW), a strain of rat that does not develop thyroiditis after treatment with MC.
mesh_terms: D000818:Animals; D005260:Female; D008748:Methylcholanthrene; D051381:Rats; D011915:Rats, Inbred BUF; D011917:Rats, Inbred Lew; D013961:Thyroid Gland / Q000473:pathology; D013966:Thyroiditis / Q000139:chemically induced / Q000235:genetics*; D014132:Trachea / Q000473:pathology
chemical_list: D008748:Methylcholanthrene