Secretion of Ia antigens by a subpopulation of T cells which are Ly-1+, Ly-2-, and Ia-.
It was found that Ia antignes are rapidly secreted by a subpopulation of splenic T lymphocytes which are nonadherent and which express the surface phenotype Ly-1+, Ly-2-, and Ia-. Secretion of the Ia antigens was a metabolically active process which was inhibited by sodium azide and by Pactamycin, an inhibitor of protein synthesis.
D000818:Animals; D007519:Isoantigens; D051379:Mice; D008815:Mice, Inbred Strains; D013499:Surface Properties; D013601:T-Lymphocytes / Q000276:immunology* / Q000378:metabolism
D007519:Isoantigens