An inhibitor of chemotaxis and phagocytosis in reticulum cell sarcoma.
In a study of neutrophil functions in haematological disorders using in vitro techniques, a heat-stable inhibitor of chemotaxis and phagocytosis was demonstrated in the plasma and serum of a 64-year-old woman with reticulum cell sarcoma. In partial purification by chromatography, the inhibitor activity could not be separated from IgG. Clinically the patient did not exhibit abnormal susceptibility to infections.
D000368:Aged; D001770:Blood Bactericidal Activity; D002633:Chemotaxis; D005260:Female; D006358:Hot Temperature; D006801:Humans; D007074:Immunoglobulin G; D008228:Lymphoma, Non-Hodgkin / Q000097:blood* / Q000276:immunology; D009504:Neutrophils; D010587:Phagocytosis
D007074:Immunoglobulin G