title: [Therapeutic results achieved through the advantage of a combination of oral metronidazole and vaginal natamycin tablets in urogenital protozoan, trichobacterial and blastomyces infections].
abstract: Vaginal inflammations caused by Trichomonas, Leptothrix vaginalis or Candida and other less common organisms respectively, were treated very successfully with a combination of metronidazole orally and a natamycin preparation vaginally (Pimafucin vaginal tablets). In women with urogenital Trichomoniasis a cure was obtained in 96,1% of the cases (microbiologically controlled); Candida mycoses of the vagina were cured clinically in 89% of the cases after the first course of treatment and mycologically in 79% of the cases. Of special importance is the rapid and successful elimination of the mixed infection before birth, because this diminishes perinatal morbidity of the fetus. The combination treatment of bilateral, constantly interchanging Candida and Trichomonas infections of the vagina is of importance to both sexes, especially with respect to the elimination of sterility. From the onco-gynecological point of view the combination treatment with metronidazole and natamycin appeared to be of value as it limits the incidence of dyskariosis of the epithelial cells, which occur frequently in cases of inflammation of the vagina or cervix uteri. No teratogenic effect was observed with this combination when applied during pregnancy.
mesh_terms: D000284:Administration, Oral; D001759:Blastomycosis / Q000188:drug therapy*; D002181:Candidiasis, Vulvovaginal / Q000188:drug therapy; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D008795:Metronidazole / Q000008:administration & dosage / Q000627:therapeutic use*; D010866:Natamycin / Q000008:administration & dosage / Q000627:therapeutic use*; D011528:Protozoan Infections / Q000188:drug therapy*; D014247:Trichomonas Vaginitis / Q000188:drug therapy; D014627:Vaginitis / Q000188:drug therapy*
chemical_list: D008795:Metronidazole; D010866:Natamycin
vernacular_title: Therapieerfolge durch den Vorteil einer Kombination von peroralem Metronidazol und Natamycin-Scheidentabletten bei urogenitalen Protozoen-, Trichobakterien- und Sprosspilzinfektionen