title: Intravitreal injection of vancomycin in experimental staphylococcal endophthalmitis.
abstract: Toxicity, clearance, and therapeutic effectiveness of intravitreal vancomycin hydrochloride injection in experimentally induced staphylococcal endophthalmitis were evaluated. Vancomycin was found to be nontoxic in a single, 1 mg/0.1 ml intravitreal dose. Therapeutic levels of vancomycin were present in the vitreous for over 72 hours and in the aqueous during a period from 6 to 48 hours after injection. Injection of a methicillin-resistant Staphylococcus aureus produced a panophthalmitis in our systemically treated controls, whereas in the rabbits treated by intraocular injection, the course of the infection was significantly altered.
mesh_terms: D000818:Animals; D002986:Clinical Trials as Topic; D003315:Cornea / Q000187:drug effects; D004353:Drug Evaluation, Preclinical; D004352:Drug Resistance, Microbial; D009877:Endophthalmitis / Q000188:drug therapy*; D007267:Injections; D008657:Metabolic Clearance Rate; D011817:Rabbits; D012160:Retina / Q000187:drug effects; D013203:Staphylococcal Infections / Q000188:drug therapy*; D013211:Staphylococcus aureus / Q000187:drug effects; D013997:Time Factors; D014640:Vancomycin / Q000008:administration & dosage* / Q000494:pharmacology / Q000633:toxicity; D014822:Vitreous Body
chemical_list: D014640:Vancomycin