[Comparison of the antiangina pectoris action of 2 coronary vasodilators].
Twenty four patients were studied: 7 males and 17 females, with an average age of 56 plus and minus 6.93 years, with a main diagnosis of ischaemic heart disease and with an average of at least 7 angina attacks per week. The anti-angina effect of 2 drugs, dipridamol and pentaeritritol was compared using the random double blind technique on parallel groups which were comparable. Pentaertritol administered for 4 weeks reduced, with a statistical significance (P 0.01), the average number of angina attacks of the group, as well as with taking nitroglicerine tablets. The number of pain free days was increased from 1.5 per week to 5.5 in 7 days. The effort capacity of the patients increased (P 0.01), and also the degree of elevation of the ST segment during and post effort. The changes obtained in these same areas with dipiridamol had no statistical significance.
D000328:Adult; D000368:Aged; D000787:Angina Pectoris / Q000188:drug therapy*; D001794:Blood Pressure / Q000187:drug effects; D002648:Child; D002986:Clinical Trials as Topic; D004176:Dipyridamole / Q000494:pharmacology / Q000627:therapeutic use*; D004341:Drug Evaluation; D005080:Exercise Test; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010417:Pentaerythritol Tetranitrate / Q000494:pharmacology / Q000627:therapeutic use*; D010919:Placebos; D011674:Pulse / Q000187:drug effects
D010919:Placebos; D010417:Pentaerythritol Tetranitrate; D004176:Dipyridamole
Estudio comparativo de la acción antianginosa de dos vasosdilatadores coronarios