title: Effects of the ultimobranchial and parathyroid glands and vitamins D2, D3 and dihydrotachysterol2 on blood calcium and intestinal calcium transport in the frog.
abstract: Administration of 500 mug vitamin D2 or D3 with ingestion of calcium to ultimobranchialectomized (UBX) or UBX-parathyroidectomized (PTX) frogs (Rana pipiens) induced hyerpcalcemia and hypercalciuria not apparent in control or PTX frogs. Calcium transport in isolated everted gut sacs was significantly elevated in UBX and UBX-PTX frogs but not in controls or PTX animals. Further, with Vitamin D3 in UBX frogs the duodenal segment had a greater capacity to transport calcium than the jejunal-ileal segment when compared to control, PTX or UBX-PTX frogs. Dihydrotachysterol2 and calcium ingestion also induced hypercalcemia, hypercalciuria and increased calcium transport in gut of UBX and UBX-PTX frogs, with no change seen in PTX or controls after 5 days. The inhibitory influence of the ultimobranchial glands on intestinal calcium transport apparently does not require the presence of the parathyroids and exhibits an inhibitory influence against a high calcium gradient across the duodenal segment.
mesh_terms: D000818:Animals; D001692:Biological Transport / Q000187:drug effects; D002118:Calcium / Q000097:blood / Q000378:metabolism* / Q000652:urine; D002136:Calcium, Dietary; D004097:Dihydrotachysterol / Q000494:pharmacology*; D004386:Duodenum / Q000378:metabolism; D007082:Ileum / Q000378:metabolism; D066298:In Vitro Techniques; D007413:Intestinal Mucosa / Q000378:metabolism*; D007583:Jejunum / Q000378:metabolism; D008297:Male; D010280:Parathyroid Glands / Q000502:physiology*; D011894:Rana pipiens; D012621:Seasons; D013268:Stimulation, Chemical; D013997:Time Factors; D014460:Ultimobranchial Body / Q000502:physiology*; D014815:Vitamins / Q000494:pharmacology*
chemical_list: D002136:Calcium, Dietary; D014815:Vitamins; D004097:Dihydrotachysterol; D002118:Calcium