[Dynamics of the antismallpox antibodies detectable in the passive hemagglutination reaction with various animal immunization schemes].
Dynamics of accumulation and preservation of antibodies detectable in the PHAT (PHAT-AT) was studied on rabbits and guinea pigs with the use of various doses of the living inactivated virus and their combination in comparison with the virus-neutralizing antibodies, antihemagglutinins and precipitins. Accumulation of the virus-neutralizing antibodies did not coincide in time with the curve of the PHAT-AT accumulation; the titres of the virus-neutralizing antibodies were higher than the PHAT-AT titres. At the same time the percentage of seroconversions determined by PHAT was equal to 100 and the PHAT-AT level directly depended on the immunizing dose, the time of administration and the type of the antigen. On the basis of the data obtained PHAT could be recommended as a test for the assessment of the immunological efficacy of the smallpox vaccinations.
D000818:Animals; D000888:Antibodies, Anti-Idiotypic / Q000032:analysis; D000914:Antibodies, Viral / Q000032:analysis*; D000956:Antigens, Viral / Q000008:administration & dosage; D004305:Dose-Response Relationship, Drug; D006168:Guinea Pigs; D006386:Hemagglutination Tests; D006389:Hemagglutinins, Viral / Q000032:analysis; D007114:Immunization; D007115:Immunization Schedule; D011234:Precipitins / Q000032:analysis; D011817:Rabbits; D012899:Smallpox / Q000276:immunology*; D012900:Smallpox Vaccine / Q000008:administration & dosage; D013997:Time Factors
D000888:Antibodies, Anti-Idiotypic; D000914:Antibodies, Viral; D000956:Antigens, Viral; D006389:Hemagglutinins, Viral; D011234:Precipitins; D012900:Smallpox Vaccine
Dinamika protivoospennykh antitel, vyiavliaemykh v reaktsii passivnoĭ gemaggliutinatsii, pri razlichnykh skhemakh immunizatsii zhivotnykh