Trigger factors and HL-A antigens in chronic active hepatitis.
Forty-six patients with histologically verified chronic active hepatitis (CAH) were divided into three groups according to whether the CAH was virus-induced, drug-induced, or cryptogenic. The frequency of the HL-A antigens 1 and 8 was increased in the cryptogenic group while the other groups did not differ significantly from healthy controls. Autoantibodies were often found in high titres in the drug-induced and cryptogenic groups but were infrequent in the virus-induced group.
D000293:Adolescent; D000328:Adult; D000368:Aged; D000974:Antibodies, Antinuclear / Q000032:analysis; D001323:Autoantibodies / Q000032:analysis; D056486:Chemical and Drug Induced Liver Injury / Q000276:immunology; D002908:Chronic Disease; D005260:Female; D006680:HLA Antigens / Q000032:analysis*; D006505:Hepatitis / Q000209:etiology / Q000276:immunology*; D006506:Hepatitis A / Q000276:immunology; D006649:Histocompatibility Antigens / Q000032:analysis*; D006801:Humans; D008297:Male; D008875:Middle Aged; D008928:Mitochondria / Q000276:immunology; D009130:Muscle, Smooth / Q000276:immunology
D000974:Antibodies, Antinuclear; D001323:Autoantibodies; D006680:HLA Antigens; D006649:Histocompatibility Antigens