title: Comparative efficacy of ampicillin and trimethoprim-sulfamethoxazole in otitis media.
abstract: Seventy-nine children with acute otitis media were the subjects in a study designed to compare the effectiveness of ampicillin and trimethoprim-sulfamethoxazole in this infection. They received either of these two agents according to a double-blind randomized procedure that also took the child's weight into account. No significant difference was found in the clinical outcome between the two treatment regimens. Undesirable side effects from TMP-SMX were notably few.
mesh_terms: D000284:Administration, Oral; D000667:Ampicillin / Q000008:administration & dosage / Q000627:therapeutic use*; D001424:Bacterial Infections / Q000188:drug therapy*; D001835:Body Weight; D002648:Child; D002986:Clinical Trials as Topic; D004338:Drug Combinations; D004341:Drug Evaluation; D006192:Haemophilus Infections / Q000188:drug therapy; D006801:Humans; D010033:Otitis Media / Q000188:drug therapy*; D011008:Pneumococcal Infections / Q000188:drug therapy; D011552:Pseudomonas Infections / Q000188:drug therapy; D013290:Streptococcal Infections / Q000188:drug therapy; D013420:Sulfamethoxazole / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D014295:Trimethoprim / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*
chemical_list: D004338:Drug Combinations; D000667:Ampicillin; D014295:Trimethoprim; D013420:Sulfamethoxazole