Comparison of intravenous oxytocin and prostaglandin E2 for induction of labour using automatic and non-automatic infusion techniques.
A double blind trial of prostaglandin E2 and oxytocin given by intravenous infusion after amniotomy for induction of labour in 100 primigravidae with unfavourable induction features is reported. No clear-cut advantage of either drug emerged although PGE2 was perhaps superior when the cervix was highly unfavourable. Prostaglandin E2 appeared to produce less deleterious effects on the fetus but was associated with a higher incidence of maternal side effects. The automatic Cardiff Infusion apparatus was found to be a safe means of PGE2 infusion and to have advantages over the use of non-automatic techniques both for PGE2 and for oxytocin infusion.
D000293:Adolescent; D000328:Adult; D000767:Anesthesia, Epidural; D002986:Clinical Trials as Topic; D005260:Female; D006801:Humans; D007263:Infusions, Parenteral / Q000379:methods*; D007751:Labor, Induced; D010121:Oxytocin / Q000008:administration & dosage* / Q000494:pharmacology / Q000627:therapeutic use; D011247:Pregnancy; D011263:Pregnancy Trimester, Third; D011273:Pregnancy, Prolonged; D011458:Prostaglandins E / Q000008:administration & dosage* / Q000494:pharmacology / Q000627:therapeutic use; D013997:Time Factors; D014590:Uterine Contraction / Q000187:drug effects
D011458:Prostaglandins E; D010121:Oxytocin