title: Differential diagnostic aspects in malignant lymphomas involving the central nervous system.
abstract: Neoplastic cells were found in the cerebrospinal fluid (CSF) cytograms in 57% of patients with lymphocytic leukemia and reticulum cell sarcoma. Tumor cells may be observed in CSF specimens showing normal cell count and total proteins. Quantitative and/or qualitative changes in CSF proteins in absence of corresponding abnormalities in serum may indicate a malignant lymphorproliferative process involving the central nervous system even in absence of neoplastic cells.
mesh_terms: D000328:Adult; D000368:Aged; D001797:Blood Protein Electrophoresis; D001932:Brain Neoplasms / Q000134:cerebrospinal fluid* / Q000175:diagnosis / Q000276:immunology; D002555:Cerebrospinal Fluid / Q000166:cytology; D002556:Cerebrospinal Fluid Proteins / Q000032:analysis; D002648:Child; D003581:Cytodiagnosis; D003937:Diagnosis, Differential; D004586:Electrophoresis; D005260:Female; D006689:Hodgkin Disease / Q000134:cerebrospinal fluid* / Q000175:diagnosis; D006801:Humans; D006942:Hypergammaglobulinemia; D007122:Immunoelectrophoresis; D007136:Immunoglobulins / Q000032:analysis / Q000134:cerebrospinal fluid; D007945:Leukemia, Lymphoid / Q000134:cerebrospinal fluid; D008223:Lymphoma / Q000276:immunology; D016403:Lymphoma, Large B-Cell, Diffuse / Q000134:cerebrospinal fluid / Q000175:diagnosis; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D013120:Spinal Cord Neoplasms
chemical_list: D002556:Cerebrospinal Fluid Proteins; D007136:Immunoglobulins