"Topical nephropathy" and "tropical extramembranous glomerulonephritis" of unknown aetiology in Senegal.
A study of renal biopsy specimens obtained in Senegal from 24 children and six adults with nephrotic syndrome showed two unusual varieties of nephropathy--namely, an extramembranous glomerulonephritis associated with hypocomplementaemia (four cases), a combination previously described only in systemic lupus erythematosus, and a "tropical nephropathy" (16 cases). The latter, though lacking the diffuse glomerular deposits of immunoglobulin described in quartan malarial nephropathy (Q.M.N.), showed a curious progressive and segmental glomerulosclerosis, characterized by a "flaking" or fibrillary splitting of the glomerular capillary wall, seen in Q.M.N. Serological evidence of malaria was lacking in a third of the childhood cases.
D000328:Adult; D000906:Antibodies / Q000032:analysis; D001485:Basement Membrane / Q000473:pathology; D001706:Biopsy; D002196:Capillaries / Q000473:pathology; D002648:Child; D003165:Complement System Proteins / Q000032:analysis; D005455:Fluorescent Antibody Technique; D005921:Glomerulonephritis / Q000473:pathology*; D006801:Humans; D007136:Immunoglobulins / Q000032:analysis; D007674:Kidney Diseases / Q000209:etiology / Q000473:pathology*; D007678:Kidney Glomerulus / Q000473:pathology; D008288:Malaria / Q000150:complications; D009404:Nephrotic Syndrome / Q000473:pathology; D010963:Plasmodium falciparum / Q000276:immunology; D012675:Senegal
D000906:Antibodies; D007136:Immunoglobulins; D003165:Complement System Proteins