title: Mouse effector functions involved in the antibody-dependent cellular cytotoxicity to xenogeneic erythrocytes.
abstract: Mouse spleen cell populations were fractionated by carbonyl iron depletion and nylon wool column separation. The fractions were tested for phagocytic and lytic activity against antibody-coated 51Cr-labeled sheep red blood cells. Carbonyl iron resistant cells had no phagocytic activity but caused lysis at a relatively slow rate. Nylon wool column nonadherent cells had a similar effect. In contrast with the slow lytic action of these cells, nylon wool adherent cells or non-carbonyl iron-treated cells had phagocytic as well as rapid lytic action. Under the conditions studied, both rapid and slow lytic functions were saturable whereas the phagocytic function was not.
mesh_terms: D000818:Animals; D000937:Antigen-Antibody Reactions; D001202:Ascitic Fluid / Q000276:immunology; D002448:Cell Adhesion; D002469:Cell Separation; D002645:Chickens; D003601:Cytotoxicity Tests, Immunologic; D004912:Erythrocytes / Q000276:immunology*; D005260:Female; D005455:Fluorescent Antibody Technique; D006461:Hemolysis; D007111:Immunity, Cellular; D051379:Mice; D008809:Mice, Inbred C3H / Q000276:immunology*; D010587:Phagocytosis; D011947:Receptors, Antigen, B-Cell; D012756:Sheep; D013154:Spleen / Q000276:immunology
chemical_list: D011947:Receptors, Antigen, B-Cell