T and B lymphocytes in multiple sclerosis.
The percentage and total number of E and EAC rosettes, as indicators of T and B lymphocytes respectively, were studied in the blood of subjects with multiple sclerosis (MS) and normals. MS patients in acute exacerbation were found to have a decrease in E rosettes and an increase in EAC rosettes. The relationship of these findings to the pathogenesis of MS is unclear; several possible pathogenetic implications are considered.
D000328:Adult; D000367:Age Factors; D000368:Aged; D001402:B-Lymphocytes / Q000276:immunology*; D002452:Cell Count; D006801:Humans; D007104:Immune Adherence Reaction; D008875:Middle Aged; D009103:Multiple Sclerosis / Q000276:immunology*; D013601:T-Lymphocytes / Q000276:immunology*