[The palatine tonsils and immunity. Report VII. Soluble factors produced by the lymphocytes of the palatine tonsils in vitro].
A study was made of the production of a blastogenic factor and lymphotoxin in the cultures of lymphocytes of the palatine tonsils removed from patients with chronic tonsillitis; the activity of this blastogenic factor and lymphotoxin was studied in the test-cultures of autologous and allogenic lymphocytes and the transplantable HeLa cells. The antigens of the pathogenic streptococcus and staphylococcus induced production of the blastogenic factor and lymphotoxin; as to the antigens of saprophytic bacteria-they produced no such action. The antigen-specific blastogenic factor intensified the immune response to the homologous antigen, whereas the factor obtained in stimulation of lymphocytes with PHA-to all the microbial antigens under study.
D000941:Antigens; D006367:HeLa Cells; D006801:Humans; D037102:Lectins; D008214:Lymphocytes / Q000276:immunology*; D008233:Lymphotoxin-alpha / Q000096:biosynthesis*; D014066:Palatine Tonsil / Q000276:immunology*; D013210:Staphylococcus / Q000276:immunology; D013291:Streptococcus / Q000276:immunology
D000941:Antigens; D037102:Lectins; D008233:Lymphotoxin-alpha
Nebnye mindaliny i immunitet. Soobshchenie VII. Rastvorimye faktory, produtsiruemye limfotsitami nebnykh mindalin in vitro