Inhibition of tumor growth in syngeneic chimeric mice mediated by a depletion of suppressor T cells.
Syngeneic chimeric (lethally irradiated and reconstituted with syngeneic bone marrow cells) mice manifested an increased resistance to the development of Lewis lung carcinoma. In addition, these mice had a higher response to polyvinylpyrrolidone and a reduced reactivity to T mitogens. The present findings suggest that syngeneic chimeric mice lack suppressor T cells shown to regulate the development of Lewis lung tumor and the response to polyvinylpyrrolidone. Other components of the T cell population, such as helper cells responding to sheep red blood cells or cells involved in allograft rejection, assayed in these syngeneic chimeras were found unaffected. The fact that chimeric mice are deficient in a certain suppressor T cell population whereas other T activities are normal suggests the existence of different cell lines within the T cell population.
D000818:Animals; D000917:Antibody Formation; D001853:Bone Marrow / Q000276:immunology; D001854:Bone Marrow Cells; D003208:Concanavalin A; D004926:Escherichia coli / Q000276:immunology; D005260:Female; D006084:Graft Rejection; D006462:Hemolytic Plaque Technique; D037102:Lectins; D008070:Lipopolysaccharides; D008175:Lung Neoplasms / Q000276:immunology; D008213:Lymphocyte Activation; D008212:Lymphocyte Depletion; D051379:Mice; D009368:Neoplasm Transplantation; D011135:Polysaccharides, Bacterial; D011828:Radiation Chimera; D016038:Skin Transplantation; D013601:T-Lymphocytes / Q000276:immunology*; D014184:Transplantation, Homologous
D037102:Lectins; D008070:Lipopolysaccharides; D011135:Polysaccharides, Bacterial; D003208:Concanavalin A