Characteristics of mesenteric lymph node cells homing to gut-associated lymphoid tissue in syngeneic mice.
A subpopulation of cells in murine mesenteric lymph nodes, about 15% of those synthesizing DNA at any given time, homes specifically to the gut and mesenteric nodes of syngeneic recipients within 1 day of i.v. transfer. In contrast, cells from Oeyer's patches or peripheral lymph nodes do not. A large proportion of the B blasts which home to the small intestine has surface Ig, but lacks complement receptors. Thy-1-positive T blasts home to the gut to a lesser extent than B blasts. However, it is probable that equal fractions of B and T blasts home to mesenteric nodes. Homing is not affected by measures calculated to interfere with the combination of cell surface IgA and secretory component.
D000818:Animals; D001402:B-Lymphocytes / Q000378:metabolism; D002478:Cells, Cultured; D004247:DNA / Q000096:biosynthesis; D005260:Female; D007275:Injections, Intravenous; D007420:Intestine, Large / Q000032:analysis; D007421:Intestine, Small / Q000032:analysis / Q000276:immunology*; D008099:Liver / Q000032:analysis; D008198:Lymph Nodes / Q000276:immunology*; D008214:Lymphocytes; D008221:Lymphoid Tissue / Q000276:immunology; D008297:Male; D008643:Mesentery / Q000276:immunology*; D051379:Mice; D008807:Mice, Inbred BALB C; D010581:Peyer's Patches / Q000032:analysis; D013154:Spleen / Q000032:analysis; D013601:T-Lymphocytes / Q000378:metabolism; D014184:Transplantation, Homologous
D004247:DNA