Reversal of acute myocardial ischemia in closed chest animals by retrograde perfusion of the coronary sinus with arterial blood.
The fundamental objective of this study was to develop a technique for salvaging aco the ischemic muscle segment is the coronary venous system. We have been able to ration) in closed chest dogs by placing a double lumen balloon catheter in the coronary sinus, and perfusing it with blood derived from a peripheral artery. We have been able to partially reverse these same manifestations in similar dogs with an ischemic period of 30-60 minutes.
D000818:Animals; D003331:Coronary Vessels; D004285:Dogs; D005112:Extracorporeal Circulation / Q000379:methods*; D009203:Myocardial Infarction / Q000628:therapy*