Parabiotic reinnervation: surgical technic and animal care.
A technic called parabiotic reinnervation was developed to test the hypothesis that a derangement of the trophic function normally exerted by a nerve on a muscle is an element in the pathogenesis of muscular dystrophy in the 129/ReJ dydy mouse. The technic involves the reinnervation of the muscles of the anterior compartment of the hind limb of 1 animal (the recipient) by the peroneal nerve of another animal (the donor). Survival of the parabiosed animals depends on attention to nutrition and cage environment.
D000818:Animals; D006224:Cricetinae; D005260:Female; D006799:Housing, Animal; D008297:Male; D008722:Methods; D051379:Mice; D008815:Mice, Inbred Strains; D009132:Muscles / Q000294:innervation*; D009137:Muscular Dystrophy, Animal / Q000503:physiopathology; D010227:Parabiosis; D010525:Peripheral Nerves / Q000601:surgery*; D010543:Peroneal Nerve / Q000502:physiology / Q000601:surgery; D011182:Postoperative Care; D012376:Rodent Diseases / Q000503:physiopathology; D013536:Suture Techniques; D013537:Sutures