[Chloroderivatives of phenoxyacetic acid as antagonists of thyroid hormones].
A 24-hour stay of the Rana temporaria tadpoles in solutions of the sodium and diethylamine salts of 2,4-dichlorophenoxyacitic acid (with 1 and 2 mg/l, respectively) significantly inhibits their metamorphosis. An addition of these salts to a solution containing thyroidin in a concentration of 1--5 mg/l hinders the action of hormone stimulating metamorphosis. The effect of the sodium salt of 2,4-dichlorophenoxyacetic acid prevents the destruction of some tadpoles by toxic concentrations of thyroidin. The above data justify referring the chloroderivatives of the phenoxyacetic acid to antagonists of the thyroid hormones.
D015084:2,4-Dichlorophenoxyacetic Acid / Q000494:pharmacology*; D000818:Animals; D013956:Antithyroid Agents; D001001:Anura; D003864:Depression, Chemical; D008675:Metamorphosis, Biological / Q000187:drug effects; D011896:Rana temporaria; D013963:Thyroid Hormones / Q000494:pharmacology
D013956:Antithyroid Agents; D013963:Thyroid Hormones; D015084:2,4-Dichlorophenoxyacetic Acid
Khlorproizvodnye fenoksiuksusnoĭ kisloty kak antagpnisty tireoidnykh gormonov.