title: [Comparison of clinical effects of delta-9-tetrahydrocannabinol with the classic effects of hashish].
abstract: Moreau de Tours's classical studies about haschisch had pointed out to a rich symptomatology: visual and auditive hallucinations preceded by the "primordial effect": "the dissociation of ideas". This delirious state was assimilated to dream. Modern studies, conducted with Delta-9-THC, in healthy voluntaries, again suggest the comparison or even the identity of the modifications caused by cannabis with sleep and dream. 10 mg of Delta-9-THC was absorbed in sesame oil by the voluntaries, and all of them presented disturbances of their vigilance, changes of their mood, now with euphoris and now with dysphoria, and slight psycho-sensorial alterations. The voluntaries EEG showed important and specific individual reactivity. Three subjects presented an arousal tendency, three other a greater towards sleep. Slight morphological changes have appeared, such as desynchronised periods, rapid shifts between I A, I B, II stages of sleep or an hypovariable I B stage of sedation with period of occular movements resembling to REM-stage.
mesh_terms: D000328:Adult; D000339:Affect / Q000187:drug effects; D001288:Attention / Q000187:drug effects; D002188:Cannabis / Q000494:pharmacology*; D002986:Clinical Trials as Topic; D003072:Cognition Disorders / Q000139:chemically induced; D003221:Confusion / Q000139:chemically induced; D004325:Dreams; D013759:Dronabinol / Q000494:pharmacology*; D004569:Electroencephalography; D005059:Euphoria; D005260:Female; D006212:Hallucinations / Q000139:chemically induced; D006801:Humans; D007360:Intelligence / Q000187:drug effects; D008297:Male; D008875:Middle Aged; D010468:Perceptual Disorders / Q000139:chemically induced; D010554:Personality Disorders / Q000139:chemically induced; D019966:Substance-Related Disorders
chemical_list: D013759:Dronabinol
vernacular_title: Comparaison des effets cliniques du delta-9-tétra-hydro-cannabinol avec les actions classiques du haschisch