Effect of edeine on primary immunologic response in mice.
The effect of edeine on primary immune response against sheep erythrocytes in mice was studied. The response intensity was evaluated on the cellular and humoral level. The results showed significant decrease in the number of spleen cells capable of synthesizing hemolysins, and the decrease in serum level of these antibodies.
D000818:Animals; D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000494:pharmacology*; D000921:Antibody-Producing Cells / Q000187:drug effects; D004247:DNA / Q000096:biosynthesis; D004912:Erythrocytes / Q000276:immunology; D006460:Hemolysin Proteins / Q000032:analysis*; D006462:Hemolytic Plaque Technique; D007109:Immunity / Q000187:drug effects*; D007111:Immunity, Cellular / Q000187:drug effects; D007273:Injections, Intramuscular; D008297:Male; D051379:Mice; D010455:Peptides / Q000008:administration & dosage / Q000494:pharmacology; D010587:Phagocytosis / Q000187:drug effects; D011073:Polyamines / Q000008:administration & dosage / Q000494:pharmacology; D012756:Sheep / Q000276:immunology; D013154:Spleen / Q000187:drug effects / Q000276:immunology
D000900:Anti-Bacterial Agents; D006460:Hemolysin Proteins; D010455:Peptides; D011073:Polyamines; D004247:DNA