title: Preferential and cooperative binding of histone I to chromosomal mammalian DNA.
abstract: There is a strong preferential binding of histone I to lymphocyte DNA as compared to Escherichia coli DNA when large DNA fragments (2 times 10-6 daltons) are used. The binding of histone I to lymphocyte DNA and to E. coli DNA is cooperative. The distribution of preferential binding sites has been investigated on fragmented DNA. Most of the 2 times 10-6 dalton fragments were found to have at least one preferential histone I binding site, whereas most of the 2 times 10-5 dalton fragments have none.
mesh_terms: D000818:Animals; D001665:Binding Sites; D002417:Cattle; D002875:Chromosomes / Q000378:metabolism; D004247:DNA / Q000302:isolation & purification / Q000378:metabolism*; D004269:DNA, Bacterial / Q000378:metabolism; D004926:Escherichia coli; D006657:Histones / Q000378:metabolism*; D008214:Lymphocytes / Q000032:analysis / Q000648:ultrastructure; D008970:Molecular Weight; D009994:Osmolar Concentration; D011485:Protein Binding; D012965:Sodium Chloride
chemical_list: D004269:DNA, Bacterial; D006657:Histones; D012965:Sodium Chloride; D004247:DNA