Requirement for T cells in the antibody response of mice to calf skin collagen.
The antibody response to triple-helical calf skin collagen is apparently regulated by T cells since nude mice (BALB/c strain) responded to this antigen only after transfer of T cells. Syngeneic transfer of B and T cells was required to prepare thymectomized and irradiated normal C57B1/10 recipients for an anti-collagen response. Reconstitution by B cells alone was unsuccessful. The results are compatible with previous evidence on the H-2 linked genetic control of the antibody response to and the non-repetitious nature of helical antigenic determinants in calf collagen.
D000818:Animals; D000917:Antibody Formation; D001402:B-Lymphocytes / Q000276:immunology; D003094:Collagen / Q000276:immunology*; D007116:Immunization, Passive; D051379:Mice; D008807:Mice, Inbred BALB C; D008810:Mice, Inbred C57BL; D008819:Mice, Nude; D013601:T-Lymphocytes / Q000276:immunology*; D013934:Thymectomy
D003094:Collagen