Effects of 3-acetylpyridine on spontaneous alternation in the mouse.
When administered to mice, 3-acetylpyridine has been shown to selectively destroy the hippocampa neural fields CA3 and CA4. Adult mice, injected i.p. with150 mg/kg 3-acetylpyridine showed a reduced frequency of spontaneous alteration(48%) in a T-maze, compared with saline injcetd controls (73%). The pattern of latency change in the experimental mice was  consistent with a failure to habitatue normally. these behavioral effects of 3-acetylpyrdine resemble those observed following lesions of the hippocampus induced by stereotaxic surgery.
D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects*; D004193:Discrimination Learning / Q000187:drug effects; D006185:Habituation, Psychophysiologic / Q000187:drug effects; D006624:Hippocampus / Q000187:drug effects*; D008297:Male; D051379:Mice; D011725:Pyridines / Q000494:pharmacology*; D013238:Stereotaxic Techniques
D011725:Pyridines