Possible effect of maternal promethazine therapy on neonatal immunologic functions.
The effect of the administration of promethazine in the treatment of erythroblastosis fetalis was studied in four maternal-fetal pairs. The three infants exposed for a prolonged period of time had decreased neonatal number and function of T cells, and abnormal specific humoral immune responses. The possible role of promethazine in the induction of fetal immunoincompetence is discussed.
D000906:Antibodies; D004899:Erythroblastosis, Fetal / Q000139:chemically induced*; D005260:Female; D006801:Humans; D007104:Immune Adherence Reaction; D007109:Immunity / Q000187:drug effects*; D007075:Immunoglobulin M; D007231:Infant, Newborn; D008213:Lymphocyte Activation / Q000187:drug effects; D008431:Maternal-Fetal Exchange; D011247:Pregnancy; D011398:Promethazine / Q000009:adverse effects*; D013601:T-Lymphocytes / Q000187:drug effects; D013745:Tetanus Toxoid
D000906:Antibodies; D007075:Immunoglobulin M; D013745:Tetanus Toxoid; D011398:Promethazine