Genetics of a primaquin-resistant yeast.
Primaquin specifically inhibits mitochondrial function in yeast. Mutants resistant to primaquin have been isolated. Genetic analysis revealed that the expression of resistance in one of them was under the control of both a nuclear gene and a cytoplasmic factor (possibly a mitochondrial gene).
D003433:Crosses, Genetic; D004272:DNA, Mitochondrial / Q000502:physiology; D004352:Drug Resistance, Microbial; D005796:Genes; D008540:Meiosis; D008928:Mitochondria / Q000187:drug effects; D008938:Mitosis; D009154:Mutation; D010641:Phenotype; D011319:Primaquine / Q000494:pharmacology*; D012441:Saccharomyces cerevisiae / Q000187:drug effects* / Q000648:ultrastructure
D004272:DNA, Mitochondrial; D011319:Primaquine