title: The effect of co-trimoxazole on antitoxin response to tetanus toxoid.
abstract: The effect of a 4-day course of co-trimoxazole (Septrin) on antitoxin response to tetanus vaccine was assessed in a double-blind study involving 22 healthy adults. The tetanus antitoxin levels were measured by in vivo and in vitro methods for up to 8 weeks after the first of two injections of tetanus vaccine, given 4 weeks apart. No sigificant difference was observed in the level of tetanus antitoxin produced in subjects who received co-trimoxazole (Septrin) in recommended therapeutic dosage during the first 4 days of the trial from that in subjects who received placebo tablets. The results indicate that a 4-day course of co-trimoxazole (Septrin) does not affect antibody production.
mesh_terms: D000818:Animals; D000917:Antibody Formation / Q000187:drug effects; D002986:Clinical Trials as Topic; D004338:Drug Combinations; D006168:Guinea Pigs; D006386:Hemagglutination Tests; D006801:Humans; D007114:Immunization; D010919:Placebos; D013420:Sulfamethoxazole / Q000494:pharmacology*; D013743:Tetanus Antitoxin / Q000378:metabolism*; D013745:Tetanus Toxoid / Q000378:metabolism*; D013997:Time Factors; D014295:Trimethoprim / Q000494:pharmacology*; D014611:Vaccination
chemical_list: D004338:Drug Combinations; D010919:Placebos; D013743:Tetanus Antitoxin; D013745:Tetanus Toxoid; D014295:Trimethoprim; D013420:Sulfamethoxazole