Histological observations of inhibitory effect of testosterone on lymphoid regeneration in the thymus-independent areas of B mice.
High doses of testosterone were subcutaneously given to B mice, neonatally thymectomized, lethally irradiated and reconstituted with syngeneic bone marrow cells. Histological observations of the peripheral lymphoid tissues revealed that testosterone inhibited the regeneration of the thymus-independent areas which were considered to be composed mainly of B lymphocytes. This result suggests that testosterone would inhibit the differentiation of B lymphocytes.
D000818:Animals; D001402:B-Lymphocytes / Q000187:drug effects*; D005260:Female; D008198:Lymph Nodes / Q000166:cytology / Q000187:drug effects; D051379:Mice; D008809:Mice, Inbred C3H; D012038:Regeneration / Q000187:drug effects*; D013154:Spleen / Q000166:cytology / Q000187:drug effects; D013739:Testosterone / Q000494:pharmacology*
D013739:Testosterone