Effect of glucagon on meal-induced gastric secretion in man.
The effect of glucagon on gastric acid and pepsin secretion, basal or stimulated by a meal, pentagastrin and histamine, was studied in duodenal ulcer patients. Intravenous glucagon infused in graded doses ranging from 6.2 to 50 mug per kg-hr produced a dose-related inhibition of pentagastrin-induced acid secretion reaching about 40% of the control level at the dose of 50 mug per kg-hr. Acid inhibition was paralleled by a decrease in the pepsin output and serum calcium level and was accompanied by a rise in the blood glucose concentration. Glucagon used in a standard dose of 25 mug per kg-hr produced about 50% inhibition of acid secretion induced by a meal (measured by intragastric titration) accompanied by a significant decrease in the serum gastrin level measured by radioimmunoassay. Histamine-induced secretion was only slightly inhibited by glucagon, and the degree of inhibition for acid (25%) and pepsin (20%) secretion was statistically insignificant.
D000328:Adult; D004305:Dose-Response Relationship, Drug; D004381:Duodenal Ulcer / Q000503:physiopathology; D005502:Food; D005745:Gastric Acidity Determination; D005750:Gastric Juice / Q000378:metabolism*; D005753:Gastric Mucosa / Q000378:metabolism*; D005755:Gastrins / Q000097:blood; D005934:Glucagon / Q000008:administration & dosage / Q000494:pharmacology*; D006632:Histamine / Q000494:pharmacology; D006801:Humans; D007275:Injections, Intravenous; D010418:Pentagastrin / Q000494:pharmacology; D010434:Pepsin A / Q000378:metabolism*; D011863:Radioimmunoassay; D012636:Secretory Rate / Q000187:drug effects
D005755:Gastrins; D006632:Histamine; D005934:Glucagon; D010434:Pepsin A; D010418:Pentagastrin