Genetic control of the immune response in rats to the known sequential polypeptide (Tyr-Glu-Ala-Gly)n. I. Antibody responses.
In inbred rats, the antibody response to the known sequential polypeptide (Tyr-Glu-Ala-Gly)n (T-G-A-Gly)n is under the control of two independently assorting loci; (co) dominant, Ag-B-linked Ir-(T-G-A-Gly) I, controlling qualitative responsivenss, and a non-Ag-B-linked modifier locus termed Ir-(T-G-A-Gly) II, controlling the level of antibody produced. The antibody response to (T-G-A-Gly)n was solely IgG and the level of antibody produced was dependent upon Ir-(T-G-A-Gly) II for phenotypic response type.
D000276:Adjuvants, Immunologic / Q000494:pharmacology; D000409:Alanine / Q000276:immunology*; D000595:Amino Acid Sequence; D000818:Animals; D000917:Antibody Formation; D001666:Binding Sites, Antibody; D002874:Chromosome Mapping; D003433:Crosses, Genetic; D005973:Glutamine / Q000276:immunology*; D005998:Glycine / Q000276:immunology*; D006824:Hybridization, Genetic; D009161:Mycobacterium / Q000276:immunology; D010455:Peptides / Q000276:immunology*; D051381:Rats; D011914:Rats, Inbred BN; D011915:Rats, Inbred BUF; D011916:Rats, Inbred F344; D011917:Rats, Inbred Lew; D013045:Species Specificity; D014443:Tyrosine / Q000276:immunology*
D000276:Adjuvants, Immunologic; D010455:Peptides; D005973:Glutamine; D014443:Tyrosine; D000409:Alanine; D005998:Glycine