[New sequential therapy in the premenopause (author's transl)].
A report about the treatment of 85 women in the premenopause during 387 cycles is given. The treatment consisted in sequential therapy in form of conjugated Estrogens (Presomen) and a new synthetic Gestagen, which was given in three different modifications: from the fifth to the 24-th day of the cycle 1,25 mg Presomen a day, additionally on the last five, seven or ten days, during each period 6 respectively 5 mg Gestagen a day. It proved that both, the disfunctional haemorrhages as well as the climacteric syndrome, were favourably influenced. The mode 10+10, that is, 10 days Estrogens alone + 10 days combined with ;estagen, proved best. A sufficiently secure contraception is not guaranteed. This can be recognized by the occurence of biphasic basal temperature curves.
D000328:Adult; D001831:Body Temperature / Q000187:drug effects; D055598:Chemical Phenomena; D002621:Chemistry; D002979:Climacteric; D002986:Clinical Trials as Topic; D003267:Contraception; D004359:Drug Therapy, Combination; D004967:Estrogens / Q000008:administration & dosage* / Q000009:adverse effects / Q000494:pharmacology; D005260:Female; D006801:Humans; D008598:Menstruation / Q000187:drug effects; D008875:Middle Aged; D010060:Ovulation / Q000187:drug effects; D011277:Pregnanediones / Q000008:administration & dosage* / Q000009:adverse effects / Q000494:pharmacology; D014626:Vaginal Smears
D004967:Estrogens; D011277:Pregnanediones
Die Sequentialtherapie in der Prämenopause mit konjugierten Ostrogenen und einem Progesteronderivat