Effects of delta-9-tetrahydrocannabinol on mouse spleens.
A study was undertaken to ascertain the effects of delta-9-Tetrahydrocannabinol on the plaque forming cell response of mice immunized with sheep erythrocytes. It was found that a marked suppression of plaque forming cells occurred concomitant with a general loss of spleen cellularity following administration of delta-9-THC. These results suggest rather marked effects of this drug on antibody synthesis.
D000818:Animals; D000917:Antibody Formation / Q000187:drug effects; D001772:Blood Cell Count; D001831:Body Temperature / Q000187:drug effects; D001835:Body Weight / Q000187:drug effects; D002188:Cannabis / Q000494:pharmacology*; D013759:Dronabinol / Q000494:pharmacology*; D004912:Erythrocytes / Q000276:immunology; D005260:Female; D006462:Hemolytic Plaque Technique; D007958:Leukocyte Count; D051379:Mice; D009929:Organ Size / Q000187:drug effects; D012756:Sheep / Q000276:immunology; D013154:Spleen / Q000166:cytology / Q000187:drug effects* / Q000276:immunology
D013759:Dronabinol