title: Approaches to selectivity in cancer chemotherapy.
abstract: Most chemotherapeutic agents utilized in the treatment of cancer have toxic effects, not only on tumor cells but also on the normal replicating cells of the body. Some of these toxic effects on the normal tissues by the drug may be diminished, or more promising is the utilization of more selective drugs based on differences between the normal and the neoplastic cell.
mesh_terms: D004341:Drug Evaluation; D005493:Folic Acid Antagonists / Q000627:therapeutic use; D006801:Humans; D002955:Leucovorin / Q000627:therapeutic use; D008727:Methotrexate / Q000627:therapeutic use; D009369:Neoplasms / Q000188:drug therapy*
chemical_list: D005493:Folic Acid Antagonists; D002955:Leucovorin; D008727:Methotrexate