title: Live attenuated versus killed virus vaccines.
abstract: The discussion of the problems of production and use of killed and live virus vaccines shows that the theoretical, basic concepts of the alternative vaccination procedures are equivalent in regard to the ideals of calculable potency and safety. If one compares the present stages of development, then it becomes evident that the advantages of live viral vaccination are due to greater potency. However, killed virus vaccines are safer. Nevertheless, these differences are not without limits. In some vaccinating procedures, the live virus vaccine is the safer of the two.
mesh_terms: D000328:Adult; D000906:Antibodies; D000956:Antigens, Viral / Q000302:isolation & purification; D002869:Chromosome Aberrations; D003429:Cross Reactions; D046508:Culture Techniques; D012321:DNA-Directed RNA Polymerases; D004812:Epidemiologic Methods; D005260:Female; D006801:Humans; D006968:Hypersensitivity, Delayed / Q000209:etiology; D006969:Hypersensitivity, Immediate / Q000209:etiology; D007117:Immunization, Secondary; D007070:Immunoglobulin A; D009092:Mucous Membrane / Q000276:immunology; D011247:Pregnancy; D011309:Preservation, Biological; D012313:RNA / Q000302:isolation & purification; D014613:Vaccines, Attenuated; D014765:Viral Vaccines / Q000009:adverse effects / Q000302:isolation & purification; D014774:Virulence; D014776:Virus Cultivation
chemical_list: D000906:Antibodies; D000956:Antigens, Viral; D007070:Immunoglobulin A; D014613:Vaccines, Attenuated; D014765:Viral Vaccines; D012313:RNA; D012321:DNA-Directed RNA Polymerases