Interaction between arginase and L-ornithine carbamoyltransferase in Saccharomyces cerevisiae. The regulatory sites of arginase.
The inhibition of ornithine carbamoyltransferase by arginase in Saccharomyces cerevisiae, which is under the control or arginine and ornithine, involves a regulatory site for arginine on the arginase distinct from its catalytic site. This regulatory site is responsible for the reinforcement effect of arginine on the inhibition of ornithine carbamoyltransferase by arginase. The binding site of ornithine carbamoyltransferase on arginase is also shown by our analysis.
D000376:Agmatine / Q000494:pharmacology; D000596:Amino Acids / Q000494:pharmacology; D001119:Arginase / Q000378:metabolism*; D001120:Arginine / Q000494:pharmacology; D001665:Binding Sites; D002087:Butyrates / Q000494:pharmacology; D002918:Chymotrypsin; D006146:Guanidines / Q000494:pharmacology; D007700:Kinetics; D009952:Ornithine / Q000494:pharmacology; D009954:Ornithine Carbamoyltransferase / Q000378:metabolism*; D010421:Pentanoic Acids / Q000494:pharmacology; D011485:Protein Binding; D012441:Saccharomyces cerevisiae / Q000201:enzymology*; D014631:Valerates / Q000494:pharmacology
D000596:Amino Acids; D002087:Butyrates; D006146:Guanidines; D010421:Pentanoic Acids; D014631:Valerates; D000376:Agmatine; D001120:Arginine; D009952:Ornithine; D009954:Ornithine Carbamoyltransferase; D002918:Chymotrypsin; D001119:Arginase