The effect of vehicle composition on the release of chloramphenicol from creams and eye ointments.
The effects that formulation of topical vehicle can have on the bio-availability and effectiveness of active ingrediants are discussed with reference to steroids, salicylic acid and benzocaine.  Results obtained for chloramphenicol-containing preparations are presented, and both dissolution curves and cup-plate assays demonstrate that chloramphenicol has far superior release (and hence activity) from creams than from ophthalmic ointments.  The latter, however, produce adequate zones of inhibition, and are long-acting.
D001681:Biological Assay; D001682:Biological Availability; D002701:Chloramphenicol / Q000032:analysis / Q000494:pharmacology; D003956:Dialysis; D004926:Escherichia coli / Q000187:drug effects; D009824:Ointments; D009883:Ophthalmic Solutions; D014677:Pharmaceutical Vehicles; D013053:Spectrophotometry
D009824:Ointments; D009883:Ophthalmic Solutions; D014677:Pharmaceutical Vehicles; D002701:Chloramphenicol