Growth inhibition in normal mammalian melanocytes in vitro.
Studies on primary cultures of normal adult melanocytes from the ear skin of a black strain of guinea-pigs are reported. Melanocytes have a low proliferation rate and tend to form cohesive groups on a glass surface. The cells undergo division while maintaining close contacts with each other whereas DNA synthesis is rare in melanocytes with multiple contacts.
D000818:Animals; D001345:Autoradiography; D002452:Cell Count; D002455:Cell Division; D002465:Cell Movement; D002478:Cells, Cultured; D004247:DNA / Q000096:biosynthesis; D003712:Dendrites / Q000648:ultrastructure; D006168:Guinea Pigs; D006651:Histocytochemistry; D008544:Melanocytes / Q000378:metabolism / Q000648:ultrastructure; D008854:Microscopy, Electron; D008858:Microscopy, Phase-Contrast; D008938:Mitosis; D009040:Motion Pictures; D014176:Protein Biosynthesis; D012313:RNA / Q000096:biosynthesis
D012313:RNA; D004247:DNA