The mutagenic action of nitroimidazoles. II. Effects of 2-nitroimidazoles.
The 2-nitroimidazoles Ro-71051 (N-benzyl-2-nitro-1-imidazole-acetamide) and Ro-5-9963 (3(2-nitro-1-imidazolyl)-1,2-propanediol) increased the mutation rate of a Klebsiella pneumoniae mutant to streptomycin-resistance including streptomycin-dependence in Luria and Delbruck's fluctuation test in concentrations of 0.05-1 mM and 0.02-0.2 mM respectively. The 2-nitroimidazole, azomycin, (Ro-5-9129/001) failed to increase the mutation rate. The results are compared to those obtained with the 5-nitroimidazoles methronidazoles metronidazole, nimorazole and dimetridazole, which caused a degree of increase similar to Ro-7-1051 and Ro-59963.
D000081:Acetamides / Q000494:pharmacology; D001593:Benzyl Compounds; D007711:Klebsiella pneumoniae / Q000187:drug effects*; D009153:Mutagens; D009154:Mutation / Q000187:drug effects*; D009593:Nitroimidazoles / Q000494:pharmacology*; D011409:Propylene Glycols / Q000494:pharmacology
D000081:Acetamides; D001593:Benzyl Compounds; D009153:Mutagens; D009593:Nitroimidazoles; D011409:Propylene Glycols