title: Pathogenesis of rabies in immunodeficient mice.
abstract: The HEP and ts2 strains of rabies virus inoculated intracerebrally into adult mice normally cause clinically inapparent infection. In the experiments described, this is converted into a lethal infection by immunosuppression with cyclophosphamide, which also prevented induction of immunity with vaccine. Lethal infection of HEP-inoculated mice was also observed in mice treated with antihymocytic serum, and in athymic (BALB/c-nu) nude mice.
mesh_terms: D000818:Animals; D000961:Antilymphocyte Serum / Q000494:pharmacology*; D003520:Cyclophosphamide / Q000494:pharmacology*; D005455:Fluorescent Antibody Technique; D007106:Immune Sera; D007165:Immunosuppression Therapy; D051379:Mice; D008807:Mice, Inbred BALB C; D008819:Mice, Nude; D009500:Neutralization Tests; D011817:Rabbits / Q000276:immunology; D011818:Rabies / Q000276:immunology*; D011819:Rabies Vaccines; D011820:Rabies virus / Q000276:immunology*; D013950:Thymus Gland / Q000276:immunology; D014779:Virus Replication
chemical_list: D000961:Antilymphocyte Serum; D007106:Immune Sera; D011819:Rabies Vaccines; D003520:Cyclophosphamide