title: [Study of the mechanisms of autoallergic reactions in cirrhosis of the liver].
abstract: Cell and humoral immunological tests were used in clinical examination of 47 patients suffering from cirrhosis of the liver; a mixed character of autoallergy was revealed in this form of pathology. Reproduction of passive anaphylaxis on guinea pigs with the aid of the sera and leukocytes of these patients pointed to the prevalence of cell allergy. Passive transmission of increased sensitivity to human hepatocytes from guinea pigs, preliminarily sensitized with salt extracts from human hepatocytes, to intact animals was realized. Active sensitization was accompanied by the formation of mixed allergy to the antigen obtained from the liver of a person who died accidentally, with the prevalence of the immediate type of reaction.
mesh_terms: D000818:Animals; D015478:Antigens, Heterophile; D001327:Autoimmune Diseases; D006168:Guinea Pigs; D006801:Humans; D007111:Immunity, Cellular; D007116:Immunization, Passive; D008099:Liver / Q000276:immunology*; D008103:Liver Cirrhosis / Q000276:immunology*
chemical_list: D015478:Antigens, Heterophile
vernacular_title: Izuchenie mekhanizmov autoallergicheskikh reaktsiĭ pri tsirroze pecheni