Inhibition of luteinizing hormone secretion induced by synthetic LRH by long-term treatment with glucocorticoids in human subjects.
The response of luteinizing hormone to a single injection of synthetic LRH was established in 6 women and 7 men following an intramuscular dose of 0.2mg or 0.1mg. Significant increases  of serum LH were observed in 30 min. Pretreatment with metyrapone for one day (4.5 g/sugject injection of synthetic LRH (0.1 MG/SUBJECT). Seven women, 21-48 years of age who were treated with prednisolone for a least 11/2 months were examined for responsiveness of the anterior pituitary to a single injection of synthetic LRH (0.2 MG). The secretion of LH was markedly suppressed and maximal serum levels of LH WERE OBSERVED 90 MIN FOLLOWING LRH injection.
D000328:Adult; D005260:Female; D007987:Gonadotropin-Releasing Hormone / Q000138:chemical synthesis / Q000494:pharmacology*; D006801:Humans; D007986:Luteinizing Hormone / Q000097:blood / Q000378:metabolism*; D008297:Male; D008797:Metyrapone / Q000494:pharmacology*; D010902:Pituitary Gland / Q000187:drug effects / Q000378:metabolism*; D011239:Prednisolone / Q000494:pharmacology*; D012737:Sex Factors; D013997:Time Factors
D007987:Gonadotropin-Releasing Hormone; D007986:Luteinizing Hormone; D011239:Prednisolone; D008797:Metyrapone