Specific antidiuretic effect of [Leu4, D-Arg8] vasotocin and [Mpr1, Leu4, D-Arg8] vasotocin. Comment on the idea of lipophilic properties and position 4.
[Leu4, D-Arg8] vasotocin (I) and [Mpr1, Leu4, D-Arg8] vasotocin (II) possess a considerable and very specific antidiuretic effect. In I, the change of configuration in position 8 caused an increase of the magnitude of the antidiuretic effect. In I, the change of configuration in position 8 caused by two orders and a decrease of the magnitude of the pressor effect by one order. I and II are the first vasotocin analogues reported to have a relatively high and specific antidiuretic effect.
D000818:Animals; D005260:Female; D005690:Galactose / Q000378:metabolism; D006801:Humans; D007668:Kidney / Q000187:drug effects / Q000502:physiology; D007774:Lactation / Q000187:drug effects; D008297:Male; D011247:Pregnancy; D051381:Rats; D013329:Structure-Activity Relationship; D014599:Uterus / Q000187:drug effects; D014668:Vasotocin / Q000031:analogs & derivatives* / Q000494:pharmacology
D014668:Vasotocin; D005690:Galactose