Antigen-specific and nonspecific mediators of T cell/B cell cooperation. I. Evidence for their production by different T cells.
Evidence is presented for two types of helper T cells in the mouse specific for a protein antigen, keyhole limpet hemocyanin (KLH). The first cell is able to help B cells respond to the hapten, trinitrophenyl (TNP), when coupled to KLH presumably through the participation of KLH-specific T cell factors. The second helper cell when stimulated with KLH is able to help B cells respond to red blood cell antigens, but not TNP-KLH, through the production of a non-antigen-specific factor. Both types of helper cells were shown to be present in the spleens of KLH-primed mice, although they occurred with different frequencies. They were shown to be different T cells by their segregation from each other in vitro at limiting dilution.
D000818:Animals; D000921:Antibody-Producing Cells; D001402:B-Lymphocytes / Q000276:immunology*; D002478:Cells, Cultured; D004912:Erythrocytes / Q000276:immunology; D005260:Female; D006241:Haptens; D006433:Hemocyanins; D006462:Hemolytic Plaque Technique; D006736:Horses / Q000276:immunology; D007114:Immunization; D051379:Mice; D008810:Mice, Inbred C57BL; D008811:Mice, Inbred DBA; D008974:Mollusca; D009596:Nitrophenols / Q000276:immunology; D010527:Perissodactyla / Q000276:immunology; D012710:Serum Albumin, Bovine; D012756:Sheep / Q000276:immunology; D013154:Spleen / Q000166:cytology; D013601:T-Lymphocytes / Q000276:immunology*
D006241:Haptens; D009596:Nitrophenols; D012710:Serum Albumin, Bovine; D006433:Hemocyanins