Lymphocyte subpopulations, serum IgE and total eosinophil counts in patients with bronchial asthma.
Absolute T and B lymphocytes, total eosinophil counts (TEC), and serum IgE levels were studied in twenty-three asthmatic subjects. Compared to a mean peripheral T-lymphocyte count of 1620+/-486/mm3 in twenty control subjects, the mean value in the asthmatic patients was depressed significantly at 1192+/-4 12 (P less than 0-005). T lymphopenia was observed in ten of twenty-three patients (43%). The serum IgE was elevated above the upper limits of 507 mug/ml in six of seventeen patients. TEC above 250/mm3 was observed in twelve of seventeen subjects. T lymphopenia and hyper-immunoglobulinaemia E were each associated with hypereosinophilia. No correlation was observed between T lymphopenia and hyperimmunoglobulinaemia E.
D000328:Adult; D001249:Asthma / Q000150:complications / Q000276:immunology*; D001402:B-Lymphocytes; D004804:Eosinophils; D005260:Female; D006801:Humans; D006942:Hypergammaglobulinemia; D007073:Immunoglobulin E; D007958:Leukocyte Count; D008214:Lymphocytes; D008231:Lymphopenia / Q000150:complications; D008297:Male; D008875:Middle Aged; D013601:T-Lymphocytes
D007073:Immunoglobulin E