title: An Haemophilus influenzae mutant which inhibits the growth of HP1c1 phage.
abstract: A strain of Haemophilus influenzae, called hpm- inhibits the growth of phage HP1c1 but not S2. This inhibition is overcome by HP1c1ph mutants. Phage HP1c1 adsorbs normally to hpm- cells but only a small fraction of infected cells produce phage with a normal burst size or become lysogenic. When hpm- strains lysogenic for HP1c1 are induced, 100 percent of the cells yield phage. There is no degradation of phage DNA after infection of hpm- cells and HP1c1 can normally grow when its DNA is introduced into hpm- by transfection. The most probable explanation is that in hpm- cells the penetration of phage DNA is blocked. The hpm- property behaves as as unstable mutation.
mesh_terms: D001435:Bacteriophages / Q000254:growth & development; D004279:DNA, Viral; D006193:Haemophilus influenzae; D008242:Lysogeny; D009154:Mutation; D014170:Transformation, Genetic
chemical_list: D004279:DNA, Viral