Influence of D-penicillamine on the immune response of mice.
Studies on the influence of D-ss, ss-dimethylcystein (D-penicillamine, Metalcaptase-R) on the primary immune response of mice after immunization with sheep red blood cells show, that D-penicillamine up to doses of 20 mg/kg has no effect on the synthesis of hemagglutinating antibodies. Plaque forming cells in the spleen were not significantly reduced after administration of 80 mg/kg. A striking inhibition of the formation of immune rosettes is demonstrated. 80 mg/kg led to a significant reduction of rosette forming B-lymphocytes in the spleen.
D000818:Animals; D000917:Antibody Formation / Q000187:drug effects; D004912:Erythrocytes / Q000276:immunology; D006386:Hemagglutination Tests; D006462:Hemolytic Plaque Technique; D007104:Immune Adherence Reaction; D007106:Immune Sera; D007109:Immunity / Q000187:drug effects*; D007111:Immunity, Cellular / Q000187:drug effects; D007075:Immunoglobulin M / Q000096:biosynthesis; D007165:Immunosuppression Therapy; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D010396:Penicillamine / Q000276:immunology / Q000494:pharmacology*; D012756:Sheep / Q000276:immunology; D013154:Spleen / Q000276:immunology
D007106:Immune Sera; D007075:Immunoglobulin M; D010396:Penicillamine