Studies on suppressor T cells in tolerance.
(1) Evidence is provided that tolerance induced in mice to HSA depends on a suppressive mechanism which inhibits the responsiveness of potentially competent cells. (2) the suppression is apparently the function of suppressor T cells which are comparatively radiosensitive and are resistant to cortisone. (3) The cortisone resistant suppressor cells are apparently the progeny of cortisone-sensitive precursors, the differentiation of which into mature suppressors seems to be signalled by antigen. (4) The precursor lymphocytes are comparatively short functioning cells (about 14 days), while the mature suppressor T cells function for at least two months.
D000818:Animals; D000941:Antigens; D003348:Cortisone / Q000494:pharmacology; D004351:Drug Resistance; D006736:Horses / Q000276:immunology; D007108:Immune Tolerance; D007156:Immunologic Memory; D007165:Immunosuppression Therapy; D008213:Lymphocyte Activation; D051379:Mice; D008815:Mice, Inbred Strains; D011830:Radiation Effects; D012709:Serum Albumin; D013601:T-Lymphocytes / Q000187:drug effects / Q000276:immunology* / Q000528:radiation effects; D013997:Time Factors
D000941:Antigens; D012709:Serum Albumin; D003348:Cortisone