In vitro and in vivo microbiological evaluation of Cephapirin, a new antibiotic.
The microbiological properties of cephapirin, a new semisynthetis cephalosporin, have been studied. This antibiotic, if compared with ampicillin, shows a greater activity against gram positive bacteria, a lack of sensitivity to staphlococcal beta-lactamase, and a lower sensitivity to those produced by gram-negative bacteria. Useful therapeutic of cephapirin levels can be detected in human serum 6 h after administration of 500 and 1,000 mg parenterally.
D000667:Ampicillin / Q000097:blood / Q000494:pharmacology; D000818:Animals; D001419:Bacteria / Q000187:drug effects* / Q000201:enzymology; D001798:Blood Proteins / Q000378:metabolism; D002511:Cephalosporins / Q000494:pharmacology*; D002514:Cephapirin / Q000097:blood / Q000494:pharmacology*; D004353:Drug Evaluation, Preclinical; D004926:Escherichia coli / Q000187:drug effects; D006801:Humans; D006867:Hydrolases / Q000494:pharmacology; D007711:Klebsiella pneumoniae / Q000187:drug effects; D051379:Mice; D008826:Microbial Sensitivity Tests; D011485:Protein Binding; D013210:Staphylococcus / Q000187:drug effects
D001798:Blood Proteins; D002511:Cephalosporins; D000667:Ampicillin; D002514:Cephapirin; D006867:Hydrolases