[Thrombolytic and pharmacodynamic properties of Aspergillus ochraceus protease].
The protease isolated from Aspergillus ochraceus exerts a strong thrombolytic action. In in vitro experiments and in tests with animals (mice, rats, dogs) it caused lysis of fibrinous clots. The thrombolytic effect of the protease is conditioned by its direct influence on the fibrin. Besides the thrombolytic action the protease, used within a definite ranges of doses, displays antithrombotic properties. The paper cites data on the acute toxicity (in mice, rats and rabbits) and on the influence of the protease on isolated organs and on the organism of the animals.
D000818:Animals; D001230:Aspergillus / Q000201:enzymology*; D001777:Blood Coagulation / Q000187:drug effects; D001780:Blood Coagulation Tests; D001792:Blood Platelets / Q000187:drug effects; D001794:Blood Pressure / Q000187:drug effects; D003018:Clot Retraction; D004285:Dogs; D005260:Female; D005340:Fibrinogen / Q000032:analysis; D005342:Fibrinolysis / Q000187:drug effects; D005343:Fibrinolytic Agents / Q000494:pharmacology*; D005859:Germany, East; D006168:Guinea Pigs; D006321:Heart / Q000187:drug effects; D066298:In Vitro Techniques; D007420:Intestine, Large / Q000187:drug effects; D007928:Lethal Dose 50; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D009132:Muscles / Q000187:drug effects; D010447:Peptide Hydrolases / Q000494:pharmacology* / Q000633:toxicity; D011817:Rabbits; D011893:Rana esculenta; D051381:Rats; D013917:Thrombin / Q000032:analysis; D013997:Time Factors
D005343:Fibrinolytic Agents; D005340:Fibrinogen; D010447:Peptide Hydrolases; D013917:Thrombin
Troboliticheskie i farmakodinamicheskie svoistva proteazy iz Aspergillus ochraceus