Neonatal pyridoxine responsive convulsions due to isoniazid therapy.
A 17-day-old infant on isoniazid therapy 13 mg/kg daily from birth because of maternal tuberculosis was admitted after 4 days of clonic fits. No underlying infective or biochemical cause could be found. The fits ceased within 4 hours of administering intramuscular pyridoxine, suggesting an aetiology of pyridoxine deficiency secondary to isoniazid medication.
D005260:Female; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007232:Infant, Newborn, Diseases / Q000139:chemically induced*; D007538:Isoniazid / Q000009:adverse effects* / Q000627:therapeutic use; D008297:Male; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious; D011736:Pyridoxine / Q000627:therapeutic use*; D012640:Seizures / Q000139:chemically induced* / Q000188:drug therapy; D014397:Tuberculosis, Pulmonary / Q000517:prevention & control*; D026681:Vitamin B 6 Deficiency / Q000139:chemically induced*
D011736:Pyridoxine; D007538:Isoniazid