title: A therapeutic response to a single diagnostic dose of luteinising hormone-releasing hormone.
abstract: Luteinising hormone-releasing hormone (LH-RH) administration is a useful provocative test for the evaluation of the hypothalamic-pituitary-gonadal axis. Seven cases with oligomenorrhoea or amenorrhoea are reported, in which a single diagnostic injection of LH-RH produced an apparent therapeutic response. Six patients converted to a regular normal menstrual cycle, and 4 of these had evidence of ovulation. The seventh patient conceived. It is postulated that in some cases of hypothalamic menstrual dysfunction the gonadotrophic imbalance may be corrected by a single intravenous dose of LH-RH.
mesh_terms: D000293:Adolescent; D000328:Adult; D000568:Amenorrhea / Q000175:diagnosis / Q000188:drug therapy; D005260:Female; D005500:Follow-Up Studies; D007987:Gonadotropin-Releasing Hormone / Q000008:administration & dosage* / Q000627:therapeutic use; D006801:Humans; D007031:Hypothalamus; D007275:Injections, Intravenous; D008598:Menstruation; D008599:Menstruation Disturbances / Q000175:diagnosis / Q000188:drug therapy*; D010060:Ovulation; D010901:Pituitary Function Tests; D011247:Pregnancy
chemical_list: D007987:Gonadotropin-Releasing Hormone