Immunotherapy of human malignant melanoma with oil-attached BCG cell-wall skeleton.
A first case of malignant melanoma treated with oil-attached BCG cell-wall skeleton (BCG-CWS) is reported. The patient, a 70-year-old farmer, with metastatic malignant melanoma was treated intralesionally with oil-attached BCG-CWS or was given intradermally with oil-attached BCG-CWS together with irradiated autologous and allogeneic tumor cells. Four months after the start of the immunotherapy with oil-attached BCG-CWS, Primary tumor and metastatic inguinal lymph nodes regressed markedly without any significant complications. Lymphocytosis in the peripheral blood was usually observed after injection of oil-attached BCG-CWS.
D000276:Adjuvants, Immunologic / Q000008:administration & dosage / Q000627:therapeutic use*; D000368:Aged; D001500:BCG Vaccine; D002473:Cell Wall / Q000276:immunology; D003601:Cytotoxicity Tests, Immunologic; D006801:Humans; D006968:Hypersensitivity, Delayed; D006969:Hypersensitivity, Immediate; D007136:Immunoglobulins / Q000032:analysis; D007264:Inguinal Canal / Q000473:pathology; D007866:Leg / Q000473:pathology; D008207:Lymphatic Metastasis; D008214:Lymphocytes / Q000276:immunology; D008297:Male; D008545:Melanoma / Q000276:immunology / Q000473:pathology / Q000628:therapy*; D008899:Mineral Oil / Q000008:administration & dosage*; D009163:Mycobacterium bovis / Q000276:immunology* / Q000648:ultrastructure; D012878:Skin Neoplasms / Q000628:therapy*; D014034:Toes / Q000473:pathology
D000276:Adjuvants, Immunologic; D001500:BCG Vaccine; D007136:Immunoglobulins; D008899:Mineral Oil