A chemical evaluation of collagen and hydroxyproline after treatment with GK-101 (N-Chloroglycine).
The reactions of GK-101 (N-chloroglycine) with collagen and hydroxyproline, were studied with regard to caries removal. After reaction with N-chloroglycine, collagen was analyzed for bound available chlorine by iodiometric titration, and hydroxyproline conversion to pyrrole-2-carboxylic acid was measured by they production of a red chromogen after PAB treatment. The results indicated that collagen was chlorinated by N-chloroglycine and hydroxyproline was converted to pyrrole-2-carboxylic acid after N-chloroglycine reaction. These findings tend to indicate two possible pathways of N-chloroglycine protein interaction.
D002264:Carboxylic Acids / Q000032:analysis; D002700:Chloramines; D003094:Collagen / Q000032:analysis* / Q000037:antagonists & inhibitors*; D003731:Dental Caries / Q000188:drug therapy; D005998:Glycine / Q000031:analogs & derivatives / Q000037:antagonists & inhibitors* / Q000494:pharmacology; D006909:Hydroxyproline / Q000032:analysis* / Q000037:antagonists & inhibitors*; D011758:Pyrroles / Q000032:analysis
D002264:Carboxylic Acids; D002700:Chloramines; D011758:Pyrroles; C012826:glycine chloramine; D003094:Collagen; D006909:Hydroxyproline; D005998:Glycine