title: Glucagon release: paradoxical stimulation by glucose during calcium deprivation.
abstract: During calsium deprivation, the rate of glucagon release by the isolated perfused rat pancreas is positively related to the glucose concentration of the perfusion medium. It is suggested that such a paradoxical behavior, which is reminiscent of the abnormality of glucagon secretion recently disclosed in diabetic subjects, results from a perturbation in the normal structural and functional bridging between pancreatic alpha and beta cells.
mesh_terms: D000818:Animals; D002118:Calcium / Q000172:deficiency*; D004305:Dose-Response Relationship, Drug; D005260:Female; D005934:Glucagon / Q000378:metabolism*; D005947:Glucose / Q000494:pharmacology*; D007515:Islets of Langerhans / Q000187:drug effects / Q000378:metabolism*; D011863:Radioimmunoassay; D051381:Rats; D013268:Stimulation, Chemical
chemical_list: D005934:Glucagon; D005947:Glucose; D002118:Calcium