title: Inhibition of d-amphetamine-induced locomotor activity by injection of haloperidol into the nucleus accumbens of the rat.
abstract: The effect of intracerebral administraton of antagonists of dopamine and noradrenaline upon the locomotor stimulation induced by intraperitoneal injection of d-amphetamine sulfate in rats was investigated. Inj ection of low doses of the dopamine antagonist haloperidol (2.5 mug and 5 mug) bilaterally into the nucleus accumbens antagonized the locomotor stimulation following d-amphetamine. No significant inhibition was observed following administration of the alpha-adrenergic antagonist phentolamine or thhe beta-adrenergic antagonist propranolol into the nucleus accumbens. Injection of the dame doses of haloperidol into the caudate nucleus did not inhibit the d-amphetamine induced locomotor activity in contrast to the effects seen following injection into the nucleus accumbens. The results confirm the significance of dopaminergic mechanisms for the locomotor stimulant effect of d-amphetamine and indicate that the mesolimbic dopamine system plays an important role in this respect.
mesh_terms: D000818:Animals; D002421:Caudate Nucleus / Q000502:physiology; D003864:Depression, Chemical; D003913:Dextroamphetamine / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D018492:Dopamine Antagonists; D006220:Haloperidol / Q000008:administration & dosage / Q000494:pharmacology*; D007267:Injections; D008297:Male; D009043:Motor Activity / Q000187:drug effects*; D009638:Norepinephrine / Q000037:antagonists & inhibitors; D009830:Olfactory Bulb / Q000502:physiology*; D010646:Phentolamine / Q000494:pharmacology; D011433:Propranolol / Q000494:pharmacology; D051381:Rats; D013238:Stereotaxic Techniques; D013997:Time Factors
chemical_list: D018492:Dopamine Antagonists; D011433:Propranolol; D006220:Haloperidol; D003913:Dextroamphetamine; D009638:Norepinephrine; D010646:Phentolamine