The ACTH-releasing hormone of the hypothalamus requires a co-factor.
Gel filtration of an extract of rat median eminence tissue in 0.1 N HCl on Sephadex G-25 separated two peaks, both with feeble ACTH-releasing activity. Full activity of the extract was regained when both peaks were recombined. This observation suggests that the ACTH-releasing hormone of the hypothalamus requires a co-factor for activity.
D000818:Animals; D001681:Biological Assay; D002850:Chromatography, Gel; D003346:Corticotropin-Releasing Hormone / Q000302:isolation & purification*; D007030:Hypothalamo-Hypophyseal System / Q000032:analysis*; D007031:Hypothalamus / Q000032:analysis*; D008473:Median Eminence / Q000032:analysis*; D009419:Nerve Tissue Proteins / Q000302:isolation & purification; D051381:Rats
D009419:Nerve Tissue Proteins; D003346:Corticotropin-Releasing Hormone