title: Management of acute aortic dissection.
abstract: The therapy for acute dissecting aneurysm of the aorta remains a difficult problem for thoracic surgeons. Because of an excessive operative mortality in patients with acute dissection who were operated on within 24 hours of hospital admission, we have utilized intensive medical management to delay surgical intervention. Even patients with acute aortic insufficiency can be supported medically, allowing their operations to be delayed at least 3 weeks or longer. Since this policy has been implemented, there has been no operative mortality in our last 13 patients with acute dissection. Medical therapy as the definitive treatment is now reserved solely for Type III dissections or for patients who cannot be operated on for other reasons. This report outlines our rationale for therapy and our current method of managing acute dissection.
mesh_terms: D000959:Antihypertensive Agents / Q000627:therapeutic use*; D001014:Aortic Aneurysm / Q000401:mortality / Q000601:surgery / Q000628:therapy*; D001027:Aortography; D001795:Blood Pressure Determination; D002496:Central Venous Pressure; D005500:Follow-Up Studies; D006145:Guanethidine / Q000627:therapeutic use; D006801:Humans; D006973:Hypertension / Q000188:drug therapy*; D007036:Hypothermia, Induced; D008722:Methods; D011300:Preoperative Care; D011433:Propranolol / Q000627:therapeutic use; D012110:Reserpine / Q000627:therapeutic use; D013536:Suture Techniques; D013997:Time Factors; D014294:Trimethaphan / Q000627:therapeutic use
chemical_list: D000959:Antihypertensive Agents; D014294:Trimethaphan; D012110:Reserpine; D011433:Propranolol; D006145:Guanethidine