Autoreactivity developing spontaneously in cultured mouse spleen cells. III. Inhibition of anti-embryo cytotoxicity in male T lymphocytes by female non-T cells.
Cultured female spleen cells develop less cytotoxicity to embryo-associated antigens than do cultured male spleen cells. This difference is less pronounced if the cells are treated before culture with a specific hetero-anti-B cell antiserum. Female non-T cells (especially from primiparous animals) can decrease the spontaneously developing T-cell cytotoxicity in male splenic T lymphocytes upon culture. By artificially manipulating the T cell: non-T cell ratio in the spleen population prior to culture, it seems one can alter the type of cytotoxic mechanism (to embryo-associated antigens) which develops in the cultures.
D000818:Animals; D000941:Antigens; D000961:Antilymphocyte Serum; D001402:B-Lymphocytes / Q000276:immunology; D002478:Cells, Cultured; D003601:Cytotoxicity Tests, Immunologic; D004622:Embryo, Mammalian / Q000276:immunology*; D005260:Female; D008264:Macrophages / Q000276:immunology; D008297:Male; D051379:Mice; D012727:Sex Characteristics; D013154:Spleen / Q000276:immunology*; D013601:T-Lymphocytes / Q000276:immunology*
D000941:Antigens; D000961:Antilymphocyte Serum