[Regeneration of the gastric mucosa under conditions of massive blood loss].
The autoradiographic method was used for a comparative study of regeneration of the gastric mucosa after wounding the rat with a preliminary loss of blood and without it. The H3-thymidin label index was determined in the portions of the mucosa of the wound edge and far from it. A histological analysis of healing the wounds failed to reveal any difference in terms of this process in rats with a loss of blood and without it. A momentary massive loss of blood did not influence the strain and intracellular regeneration processes in the healing wound of the stomach: the amount of cells synthesizing DNA at the edges of the gastrotonic wound proved to be the same in experiments both with a loss of blood and without it. The authors believe that it may serve as an indirect evidence of a somewhat exaggerated danger of surgery at the height of gastroduodenal bleeding.
D000818:Animals; D002454:Cell Differentiation; D004847:Epithelial Cells; D004848:Epithelium / Q000473:pathology; D005743:Gastrectomy; D005753:Gastric Mucosa / Q000502:physiology*; D006471:Gastrointestinal Hemorrhage / Q000503:physiopathology*; D006097:Granulation Tissue / Q000503:physiopathology; D051381:Rats; D012038:Regeneration; D013270:Stomach / Q000503:physiopathology; D013997:Time Factors; D014945:Wound Healing
Regeneratsiia slizistoĭ obolochki zheludka v usloviiakh massivnoĭ krovopoteri