[Lymphocyte in chronic lymphatic leukemia].
In patients with chronic lymphatic leukemia (CLL) the majority of peripheral blood lymphocytes was characterized as B cells by surface membrane markers. Ultrastructural studies revealed a reduction of the cytoplasmic area. Furthermore, the number of lysosomes was diminished corresponding to a decreased activity of lysosomal hydrolases. Increasing blood lymphocytosis was paralleled by an increase of the percentage of lysosome-poor lymphocytes. Response of CLL lymphocytes to in vitro stimulation with PHA and PWM was either lacking or diminished and/or delayed, and the number of transformed cells was reduced. Thus, the majority of CLL lymphocytes appears to represent both morphologically and functionally abnormal neoplastic b cells. During the early and later phase of stimulation the mitogen-reactive CLL lymphocytes exhibited alterations of the lysosomal apparatus similar to those observed in normal cells. The reactive lymphocytes may be derived from residual populations of normally functioning T and/or B cells. However, the neoplastic cells may also be able to respond to the mitogens. In vivo studies showed impaired kinetics of circulation and recirculation of CLL B lymphocytes, whereas the T cells were normal in this respect.
D001402:B-Lymphocytes / Q000473:pathology; D003593:Cytoplasm; D006801:Humans; D006867:Hydrolases; D037102:Lectins; D007945:Leukemia, Lymphoid / Q000473:pathology*; D007958:Leukocyte Count; D008213:Lymphocyte Activation; D008214:Lymphocytes / Q000201:enzymology / Q000473:pathology*; D008247:Lysosomes; D008854:Microscopy, Electron; D013499:Surface Properties; D013601:T-Lymphocytes / Q000473:pathology; D013997:Time Factors
D037102:Lectins; D006867:Hydrolases
Der Lymphozyt bei der chronischen lymphatischen Leukämie