The problem of the origin of fibroblasts in the postnatal ontogenesis of mammals.
An analysis is made of the author's data and the literature information on the origin and patterns of differentiation of the fibroblasts of connective tissue during the postnatal ontogenesis of mammals. The hypothesis of the existence of two types of collagen-producing cells (fibroblasts) - protective-trophic (short-lived population) and supporting (long-lived population) - is substantiated. Hypotheses are advanced on the biological role of these types of fibroblasts and their origin in phylogenesis.
D000818:Animals; D002455:Cell Division; D002999:Clone Cells / Q000502:physiology; D003094:Collagen / Q000096:biosynthesis; D003238:Connective Tissue / Q000502:physiology*; D005347:Fibroblasts / Q000502:physiology / Q000637:transplantation; D006410:Hematopoiesis; D006412:Hematopoietic Stem Cells / Q000502:physiology; D006801:Humans; D007249:Inflammation; D008954:Models, Biological; D009024:Morphogenesis; D013936:Thymidine / Q000378:metabolism; D014184:Transplantation, Homologous; D014316:Tritium
D014316:Tritium; D003094:Collagen; D013936:Thymidine