Surface markers on lymphocytes of multiple sclerosis patients.
Peripheral blood lymphocytes of twenty-two multiple sclerosis (MS) patients and thirty-five healthy controls were examined for the presence of surface markers characteristic for B lymphocytes (surface immunoglobulin, receptor for C3 (EAC), reporter for Fc (EA) and the spontaneous rosette-forming capacity characteristic of T cells. The results obtained indicate that the number of B and T cells in MS is similar to controls, as evaluated by the presence of surface immunoglobulin and E rosette-forming capacity. However, a statistically significant reduction in the percentage of lymphocytes bearing C3 receptors has been found in MS patients. It might have resulted from a reduction in the lymphocyte population bearing C3 receptor but no surface immunoglobulin. The EA rosette test revealed the greatest difference between the groups. The difference indicated a reduction in the density of the receptor for 7S Fc on lymphocytes from MS patients. The results obtained are consistent with the hypothesis of an immune deficit in multiple sclerosis.
D000293:Adolescent; D000328:Adult; D000818:Animals; D001666:Binding Sites, Antibody; D001667:Binding, Competitive; D002462:Cell Membrane / Q000276:immunology; D003176:Complement C3 / Q000378:metabolism; D004912:Erythrocytes / Q000276:immunology; D005455:Fluorescent Antibody Technique; D006801:Humans; D007104:Immune Adherence Reaction; D007074:Immunoglobulin G / Q000378:metabolism; D008214:Lymphocytes / Q000276:immunology*; D009103:Multiple Sclerosis / Q000276:immunology*; D011817:Rabbits; D011947:Receptors, Antigen, B-Cell / Q000032:analysis; D011955:Receptors, Drug; D012756:Sheep
D003176:Complement C3; D007074:Immunoglobulin G; D011947:Receptors, Antigen, B-Cell; D011955:Receptors, Drug