[Therapy of tuberculosis with Rifampicin in childhood (author's transl)].
Compared with the adults the child's bloodlevel after having taken Rifampicin is lower, therefore it is recommanded to take a higher dose of 15 mg/kg in the morning before having breakfasted. A combination of doses of 10 mg/kg INH and 20 mg/kg Ethambutol is possible without any doubt. If you consider the reaction which may arise, SGOT and SGPT values up to 21 mU are without any signification. If they depasse this limit a certain control is necessary and if they are still progressive the therapy must be changed. If you compare the experiences with the adults, secondary effects of Rifampicin in childhood are less, just so indigestibleness of the stomach or intestines tract or allergies.
D000410:Alanine Transaminase / Q000378:metabolism; D001219:Aspartate Aminotransferases / Q000378:metabolism; D002648:Child; D002675:Child, Preschool; D004334:Drug Administration Schedule; D004359:Drug Therapy, Combination; D004977:Ethambutol / Q000627:therapeutic use; D005260:Female; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D011247:Pregnancy; D012293:Rifampin / Q000009:adverse effects / Q000627:therapeutic use*; D014388:Tuberculosis, Lymph Node / Q000188:drug therapy; D014391:Tuberculosis, Miliary / Q000188:drug therapy; D014397:Tuberculosis, Pulmonary / Q000188:drug therapy*
D004977:Ethambutol; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase; D012293:Rifampin
Rifampicinbehandlung der Tuberkulose im Kindesalter