Failure of heavy chain glycosylation of IgG in some patients with common, variable agammaglobulinemia.
Four patients with common, variable agammaglobulinemia were preveiously reported to have normal numbers of circulating B lymphocytes which synthesized normal amounts of IgG in tissue culture but failed to secrete the newly synthesized IgG. The B lymphocytes of these patients fail to incorporate [3H]mannose and/or [3H]glucosamine into newly synthesized IgG, whereas such incorporation appears to occur just before IgG secretion in cultures of normal B lymphocytes.
D000361:Agammaglobulinemia / Q000276:immunology* / Q000378:metabolism; D001402:B-Lymphocytes / Q000276:immunology / Q000378:metabolism; D005944:Glucosamine / Q000378:metabolism; D006801:Humans; D007074:Immunoglobulin G / Q000096:biosynthesis*; D007532:Isoleucine / Q000378:metabolism; D007930:Leucine / Q000378:metabolism; D008358:Mannose / Q000378:metabolism; D014176:Protein Biosynthesis; D014633:Valine / Q000378:metabolism
D007074:Immunoglobulin G; D007532:Isoleucine; D007930:Leucine; D014633:Valine; D005944:Glucosamine; D008358:Mannose