title: [Uricolytic therapy. Value of urate oxidase in the treatment of hyperuricemias].
abstract: In addition to uricosuric agents and purine synthesis inhibitors, Urate Oxydase may be used in the treatment of hyperuricaemia. This substance breaks down uric acid to allantoin which is soluble and easily excreted. Use of the medication in 14 cases of major gout with tophi and 9 cases of hyperuricaemia secondary to renal insufficiency showed the good tolerance of the substance and it's clinical and biological effectiveness.
mesh_terms: D058186:Acute Kidney Injury / Q000150:complications; D000328:Adult; D000368:Aged; D000481:Allantoin / Q000096:biosynthesis / Q000097:blood; D055598:Chemical Phenomena; D002621:Chemistry; D002986:Clinical Trials as Topic; D005260:Female; D006073:Gout / Q000188:drug therapy*; D006801:Humans; D007676:Kidney Failure, Chronic / Q000150:complications; D008297:Male; D008659:Metabolic Diseases / Q000150:complications / Q000188:drug therapy; D008875:Middle Aged; D011687:Purines / Q000378:metabolism; D014503:Urate Oxidase / Q000378:metabolism / Q000627:therapeutic use*; D014527:Uric Acid / Q000097:blood* / Q000378:metabolism
chemical_list: D011687:Purines; D014527:Uric Acid; D000481:Allantoin; D014503:Urate Oxidase
vernacular_title: La thérapeutique uricolytique. Intérêt de l'urate oxydase dans le traitement des hyperuricémies