title: The adult respiratory distress syndrome and pancuronium bromide.
abstract: The institution and maintenance of artificial ventilation for a patient with the adult respiratory distress syndrome (ARDS) is frequently difficult because the hypoxic patient is often confused, agitated, or combative. Pancuronium bromide, a recently introduced neuromuscular blocking agent, was used to facilitate artificial ventilation in 6 patients with ARDS. As compared with morphine sulfate and diazepam, pancuronium bromide has fewer cardiovascular and central-nervous system effects. It also has fewer cardiovascular effects than does curare, and its prolonged administration does not lead to a desensitization neuromuscular block as is seen with succinylcholine. However, continuous high-quality nursing care is necessary if this drug is used.
mesh_terms: D000007:Abdominal Injuries / Q000150:complications; D000293:Adolescent; D000328:Adult; D001965:Bromides / Q000008:administration & dosage / Q000627:therapeutic use; D003490:Cyanosis / Q000150:complications; D004620:Embolism, Fat / Q000150:complications; D006556:Heroin Dependence / Q000150:complications; D006801:Humans; D000860:Hypoxia / Q000628:therapy; D007275:Injections, Intravenous; D007442:Intubation, Intratracheal; D008297:Male; D010100:Oxygen / Q000097:blood; D010197:Pancuronium / Q000008:administration & dosage / Q000627:therapeutic use*; D011175:Positive-Pressure Respiration / Q000379:methods; D011654:Pulmonary Edema / Q000150:complications; D012131:Respiratory Insufficiency / Q000209:etiology / Q000628:therapy*; D013577:Syndrome; D013848:Thigh / Q000293:injuries; D012122:Ventilators, Mechanical
chemical_list: D001965:Bromides; D010197:Pancuronium; D010100:Oxygen