title: Minoxidil in refractory hypertension.
abstract: A life-threatening, severe, hypertension refractory to conventional antihypertensive drugs developed in a 10-year-old girl in association with a functional renal transplant. Minoxidil, a new vasodilator, proved to be a life-saving antihypertensive drug and prevented the removal of the functional transplant. During 9 months of minoxidil therapy the blood pressure remained controlled and the renal transplant function excellent. No serious side effects except a moderate hypertrichosis have been observed. It appears that minoxidil can be used to control refractory, life-threatening hypertension in children.
mesh_terms: D001794:Blood Pressure; D002648:Child; D003404:Creatinine / Q000097:blood; D005260:Female; D005665:Furosemide / Q000627:therapeutic use; D006801:Humans; D006830:Hydralazine / Q000627:therapeutic use; D006973:Hypertension / Q000188:drug therapy* / Q000209:etiology; D016030:Kidney Transplantation; D008750:Methyldopa / Q000627:therapeutic use; D008775:Methylprednisolone / Q000627:therapeutic use; D008914:Minoxidil / Q000008:administration & dosage / Q000627:therapeutic use*; D011183:Postoperative Complications; D011433:Propranolol / Q000627:therapeutic use; D011743:Pyrimidines / Q000627:therapeutic use*; D012083:Renin / Q000097:blood; D014184:Transplantation, Homologous
chemical_list: D011743:Pyrimidines; D006830:Hydralazine; D008750:Methyldopa; D008914:Minoxidil; D005665:Furosemide; D011433:Propranolol; D003404:Creatinine; D012083:Renin; D008775:Methylprednisolone