title: A controlled study of a tetracyclic antidepressant--maprotiline (Ludiomil).
abstract: Maprotiline (Ludiomil) is a dibenzo bicyclooctadiene pharmacologically related to the tricyclic antidepressants and stereochemically having a tetracyclic structure. A controlled, double-blind comparison of maprotiline and imipramine in a group of 71 female outpatients with primary depression is presented. Maprotiline was found to be at least as effective as imipramine and significantly better in depressive neurosis. It also showed a bipolar action, being effective in both agitation and retardation.
mesh_terms: D000275:Adjustment Disorders / Q000188:drug therapy; D000328:Adult; D000873:Anthracenes / Q000627:therapeutic use*; D001714:Bipolar Disorder / Q000188:drug therapy; D001835:Body Weight / Q000187:drug effects; D002986:Clinical Trials as Topic; D003863:Depression / Q000188:drug therapy* / Q000503:physiopathology; D004328:Drive / Q000187:drug effects; D005260:Female; D006801:Humans; D007099:Imipramine / Q000009:adverse effects / Q000494:pharmacology / Q000627:therapeutic use; D008376:Maprotiline / Q000009:adverse effects / Q000494:pharmacology / Q000627:therapeutic use*; D011569:Psychiatric Status Rating Scales; D013997:Time Factors
chemical_list: D000873:Anthracenes; D008376:Maprotiline; D007099:Imipramine