title: Selective IgA deficiency---some perspectives.
abstract: The clinical spectrum of IgA deficiency varies from good health to respiratory, gastrointestinal, autoimmune and malignant disorders. Evaluation of B lymphocytes with surface IgA receptors in this disease reveals cap formation, decreased to normal density of IgA receptors, and IgA secretion following pokeweed stimulation. Further study of antigen-induced B-lymphocyte phenomena is needed. The presence of decreased numbers of T-cell markers in some individuals with IgA deficiency suggests a T-"helper" cell defect.
mesh_terms: D000917:Antibody Formation; D000941:Antigens; D001249:Asthma / Q000276:immunology; D001327:Autoimmune Diseases / Q000209:etiology*; D001402:B-Lymphocytes / Q000276:immunology; D001666:Binding Sites, Antibody; D002446:Celiac Disease / Q000276:immunology; D004705:Endocytosis; D004847:Epithelial Cells; D004848:Epithelium / Q000276:immunology; D005455:Fluorescent Antibody Technique; D005767:Gastrointestinal Diseases / Q000209:etiology*; D006801:Humans; D017098:IgA Deficiency; D007073:Immunoglobulin E / Q000032:analysis; D007074:Immunoglobulin G; D007075:Immunoglobulin M; D008264:Macrophages / Q000276:immunology; D009369:Neoplasms / Q000209:etiology*; D009858:Oncogenic Viruses / Q000276:immunology; D012141:Respiratory Tract Infections / Q000209:etiology*; D006255:Rhinitis, Allergic, Seasonal / Q000276:immunology; D013601:T-Lymphocytes / Q000276:immunology
chemical_list: D000941:Antigens; D007074:Immunoglobulin G; D007075:Immunoglobulin M; D007073:Immunoglobulin E