The inhibiting effect of indomethacin on the disruption of the blood-aqueous barrier in the rabbit eye.
The aqueous flare (AF) of an intact rabbit eye was measured by a photoelectric instrument. Local application of prostaglandin E2 (PGE2) and its precursor arachidonic acid (AA) gave an almost identical increase of the AF. The response to AA but not to PGE2 was inhibited by pretreating the eye locally with a solution of indomethacin. The ability of indomethacin to inhibit the aqueous flare response (AFR) to an agent is assumed to indicate that a kind of prostaglandin is the effector of the AF. Indomethacin blocked the AFR to infrared irradiation of the iris and to intravenous administration of endotoxin but not to subcutaneous administration of alpha-melanocyte-stimulating hormone (alpha-MSH).
D000287:Administration, Topical; D000818:Animals; D001082:Aqueous Humor / Q000187:drug effects / Q000502:physiology*; D001095:Arachidonic Acids / Q000008:administration & dosage / Q000494:pharmacology; D001692:Biological Transport / Q000187:drug effects; D001769:Blood; D003315:Cornea; D004731:Endotoxins / Q000008:administration & dosage / Q000494:pharmacology; D007213:Indomethacin / Q000494:pharmacology*; D007259:Infrared Rays; D007275:Injections, Intravenous; D007279:Injections, Subcutaneous; D007498:Iris / Q000528:radiation effects; D009074:Melanocyte-Stimulating Hormones / Q000008:administration & dosage / Q000494:pharmacology; D019721:Ophthalmoscopes; D011458:Prostaglandins E / Q000008:administration & dosage / Q000494:pharmacology; D011513:Proteus mirabilis; D011817:Rabbits; D011830:Radiation Effects
D001095:Arachidonic Acids; D004731:Endotoxins; D011458:Prostaglandins E; D009074:Melanocyte-Stimulating Hormones; D007213:Indomethacin