[Effectiveness of local and parenteral antibiotics in infection of aortic dacron grafts (author's transl)].
The effectiveness of local and parenteral antibiotic prophylaxis in infections of aortic dacron grafts was tested in animal experiments. In 20 foxhounds Dacron-interpositions, 4 cms in length, were inoculated with 50 million Staph aureus bacteria and then treated in 4 different ways: Nr. 1-5 no antibiotic treatment. Nr. 6-10 local antibiotic (Nebacetin, R) treatment. Nr 11-15 parenteral treatment with Gramaxin (R) i.m. Nr. 16-20 combined Nebacetin (R) and Gramaxin (R) treatment. The untreated dogs developed infection of laparotomy wounds, peritoneum udn prosthesis. Nebacetin gave improved results, whereas Gramaxin led to complete eradication of the infection. It is concluded, that antibiotic prophylaxis should be applied in vascular surgery, whenever alloplastic, homologous or autologous implants are used.
D000287:Administration, Topical; D000818:Animals; D000900:Anti-Bacterial Agents / Q000008:administration & dosage*; D001414:Bacitracin / Q000627:therapeutic use; D002437:Cefazolin / Q000627:therapeutic use; D004285:Dogs; D007275:Injections, Intravenous; D009355:Neomycin / Q000627:therapeutic use; D013530:Surgical Wound Infection / Q000188:drug therapy*
D000900:Anti-Bacterial Agents; D001414:Bacitracin; D009355:Neomycin; D002437:Cefazolin
Wirkung lokaler und parenteraler Antibiotika bei infizierten Gefässprothesen