Specific human B lymphocyte alloantigens linked to HL-A.
Sera, previously found to react specifically with B lymphoid cultured cells, were tested on isolated T and B peripheral blood lymphocytes in a microcytotoxicity assay. Studies were performed on lymphocytes obtained from several large Amish families. The sera used in these studies were cytotoxic to peripheral blood, B lymphocytes, but not cytotoxic to T lymphocytes. The antigens detected followed the inheritance pattern of HL-A haplotypes. The strong linkage disequilibrium with HL-A antigens suggests that genes controlling the expression of B lymphocyte antigens are linked to genes controlling HL-A alloantigens.
D001402:B-Lymphocytes / Q000032:analysis / Q000276:immunology*; D001665:Binding Sites; D001666:Binding Sites, Antibody; D002478:Cells, Cultured; D005260:Female; D006680:HLA Antigens / Q000032:analysis*; D006649:Histocompatibility Antigens / Q000032:analysis*; D006801:Humans; D007519:Isoantigens / Q000032:analysis*; D008297:Male; D010375:Pedigree; D011485:Protein Binding
D006680:HLA Antigens; D006649:Histocompatibility Antigens; D007519:Isoantigens