Distributions of immunoglobulin-containing cells in alimentary tract, spleen, and mesenteric lymph node of the pig demonstrated by peroxidase-conjugated antiserums to porcine immunoglobulins G, A, and M.
Peroxidase-conjugated antibody to porcine immunoglobulins A, G, and M were used in a light microscope study of the distribution of immunoglobulins and immunoglobulin-containing cells in alimentary tract, spleen, and mesenteric lymph node of the pig. Largest populations of plasma cells staining for each of the 3 immunoglobulin classes were demonstrated in the lamina propria of the intestinal tract. Immunoglobulin A cells were most numerous, and immunoglobulin A and M cells each outnumbered immunoglobulin G cells which were, however, present in considerable numbers. Both immunoglobulins A and M were demonstrated in intestinal crypt epithelial cells, indicating they have similar intracellular secretion pathways. Porcine spleen and mesenteric lymph node seem to have a minor role in immunoglobulin synthesis.
D000818:Animals; D000888:Antibodies, Anti-Idiotypic; D000921:Antibody-Producing Cells / Q000276:immunology*; D002432:Cecum / Q000276:immunology; D003106:Colon / Q000276:immunology; D004064:Digestive System / Q000276:immunology*; D004386:Duodenum / Q000276:immunology; D004847:Epithelial Cells; D004848:Epithelium / Q000276:immunology; D007082:Ileum / Q000276:immunology; D007070:Immunoglobulin A / Q000032:analysis; D007074:Immunoglobulin G / Q000032:analysis; D007075:Immunoglobulin M / Q000032:analysis; D007136:Immunoglobulins / Q000032:analysis*; D008198:Lymph Nodes / Q000276:immunology*; D008643:Mesentery / Q000276:immunology; D012007:Rectum / Q000276:immunology; D013154:Spleen / Q000276:immunology*; D013270:Stomach / Q000276:immunology; D013552:Swine / Q000276:immunology*
D000888:Antibodies, Anti-Idiotypic; D007070:Immunoglobulin A; D007074:Immunoglobulin G; D007075:Immunoglobulin M; D007136:Immunoglobulins