Genetic control of susceptibility to experimental allergic encephalomyelitis and the Ag-B locus of rats.
Injection of guinea pig spinal cord with complete Freund's adjuvant induces EAE in Lewis (Ag-B1) and DA (Ag-B4) rats, but not in rats of the BN (Ag-B3) strain. When BN is crossed with Lewis, susceptibility is determined by a gene linked to the Ag-B histocompatibility locus, but a much more complex mode of inheritance is involved when BN and DA rats are crossed. Six inbred strains possessing the Ag-B1 histocompatibility allele have been found to be susceptible to EAE. Evidence for recombination between the Ag-B locus and the gene determining susceptibility to EAE has not yet been obtained.
D000483:Alleles; D000818:Animals; D000941:Antigens; D001853:Bone Marrow / Q000276:immunology; D001854:Bone Marrow Cells; D003429:Cross Reactions; D004681:Encephalomyelitis, Autoimmune, Experimental / Q000235:genetics*; D006168:Guinea Pigs / Q000276:immunology; D006649:Histocompatibility Antigens; D007108:Immune Tolerance; D051381:Rats; D011914:Rats, Inbred BN; D016038:Skin Transplantation; D013045:Species Specificity; D013116:Spinal Cord / Q000276:immunology; D014184:Transplantation, Homologous
D000941:Antigens; D006649:Histocompatibility Antigens