title: Miconazole nitrate compared with chlordantoin in the treatment of vaginal candidiasis.
abstract: In a double-blind study of the treatment of vaginal candidiasis, miconazole nitrate gave a cure-rate of 88 per cent. (29 out of 33) compared with 58 per cent. (21 out of 36) using chlordantoin. Although approximately two-thirds of the patients who responded did so to a 10-day course of treatment, the different rates of cure with these preparations at this stage were not statistically significant. However, when a second course of treatment was given to those women who still had proven candidiasis, the overall cure-rate with miconazole was significantly greater than that with chlordantoin.
mesh_terms: D000328:Adult; D000935:Antifungal Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D002181:Candidiasis, Vulvovaginal / Q000188:drug therapy*; D002986:Clinical Trials as Topic; D003276:Contraceptives, Oral; D005260:Female; D006801:Humans; D006827:Hydantoins / Q000627:therapeutic use*; D006843:Hydrocarbons, Chlorinated / Q000627:therapeutic use; D007093:Imidazoles / Q000627:therapeutic use*; D008825:Miconazole / Q000627:therapeutic use*; D009824:Ointments; D014621:Vagina / Q000382:microbiology
chemical_list: D000935:Antifungal Agents; D003276:Contraceptives, Oral; D006827:Hydantoins; D006843:Hydrocarbons, Chlorinated; D007093:Imidazoles; D009824:Ointments; D008825:Miconazole