Immunological changes and liver disease associated with alpha1-antitrypsin deficiency.
A female aged 60 years with heterozygous alpha-1-antitrypsin deficiency developed a progressive and ultimately fatal liver disease with the clinical, biochemical, immunological and histological characteristics of active chronic hepatitis. It is suggested that the hepatic disease of A-AT deficiency be included among the types of liver disease which may initiate a progressive immunopathic response.
D002908:Chronic Disease; D005260:Female; D006505:Hepatitis / Q000209:etiology*; D006801:Humans; D007154:Immune System Diseases / Q000209:etiology*; D008875:Middle Aged; D019896:alpha 1-Antitrypsin Deficiency