title: Development of T and B cells and their functional interactions.
abstract: The development of IgM-, IgG- and then IgA-bearing B lymphocytes is an orderly process occurring independently of antigens and T cells. T cells enhance antigen-induced B lymphocyte to plasma cell differentiation according to the hierarchy: IgA greater than IgG greater than IgM. T cells also exhibit antigenindependent and dependent stages of differentiation and a functional diversity, perhaps attributable to different classes of T cells. New evidence indicates the presence of a receptor on T cells for IgM antibody produced by B cells.
mesh_terms: D000361:Agammaglobulinemia / Q000209:etiology; D000818:Animals; D000917:Antibody Formation; D000941:Antigens; D000961:Antilymphocyte Serum; D001065:Appendix / Q000276:immunology; D001402:B-Lymphocytes / Q000276:immunology*; D001666:Binding Sites, Antibody; D002060:Bursa of Fabricius / Q000276:immunology; D002454:Cell Differentiation; D002642:Chick Embryo; D002645:Chickens; D002999:Clone Cells; D005865:Gestational Age; D006412:Hematopoietic Stem Cells; D006801:Humans; D017098:IgA Deficiency; D007104:Immune Adherence Reaction; D007108:Immune Tolerance; D007075:Immunoglobulin M / Q000096:biosynthesis; D007136:Immunoglobulins / Q000096:biosynthesis; D008213:Lymphocyte Activation; D051379:Mice; D010581:Peyer's Patches / Q000276:immunology; D010950:Plasma Cells / Q000276:immunology; D011947:Receptors, Antigen, B-Cell; D013601:T-Lymphocytes / Q000276:immunology*; D013950:Thymus Gland / Q000276:immunology
chemical_list: D000941:Antigens; D000961:Antilymphocyte Serum; D007075:Immunoglobulin M; D007136:Immunoglobulins; D011947:Receptors, Antigen, B-Cell