title: Synthesis and biological properties of alkyl esters of polyene antibiotics.
abstract: Several new alkyl esters of polyene antibiotics were prepared by an improved general procedure, and their toxicity and microbiological activity were tested. Some of these alkyl esters were more active than the nonesterified polyenes against Candida albicans but were less effective than the known methyl esters. Their toxicity was much less than that of the parent compounds.
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000138:chemical synthesis / Q000494:pharmacology / Q000633:toxicity; D002176:Candida albicans / Q000187:drug effects; D004952:Esters / Q000138:chemical synthesis / Q000494:pharmacology / Q000633:toxicity; D005260:Female; D007928:Lethal Dose 50; D051379:Mice; D011090:Polyenes / Q000138:chemical synthesis / Q000494:pharmacology / Q000633:toxicity
chemical_list: D000900:Anti-Bacterial Agents; D004952:Esters; D011090:Polyenes