Bioavailability of oral dexamethasone.
Bioavailabilities of dexamethasone tablets and elixir in man were evaluated by each of 3 model-independent methods of pharmacokinetic analysis employing plasma and urinary values as determined by radioimmune assay. There were no significant differences among the results determined by the 3 methods nor between the respective availabilities of the two formulations; the latter averaged 82.6 +/- 17.7% for the elixir formulation and 78.0 +/- 12.1% for tablets.
D000284:Administration, Oral; D000293:Adolescent; D000328:Adult; D001682:Biological Availability; D002986:Clinical Trials as Topic; D003907:Dexamethasone / Q000008:administration & dosage / Q000378:metabolism*; D006801:Humans; D007263:Infusions, Parenteral; D007700:Kinetics; D008297:Male; D012996:Solutions; D013607:Tablets; D013997:Time Factors
D012996:Solutions; D013607:Tablets; D003907:Dexamethasone