title: Inhibitory effect of U.V. -irradiation on the formation of twisted circular lambda DNA.
abstract: Ultra-violet irradiation of lambda phage results in an inhibition of conversion of lambda DNA in host cells from the initial linear form to twisted circular form. The formation of open circular lambda DNA in vitro (formation of Hershey's circle) was quite resistant to the irradiation. The occurrence of denaturation of ultraviolet irradiation was detected in lambda DNA.
mesh_terms: D002501:Centrifugation, Zonal; D003090:Coliphages / Q000528:radiation effects*; D004261:DNA Replication; D004267:DNA Viruses / Q000528:radiation effects; D004270:DNA, Circular / Q000096:biosynthesis*; D004279:DNA, Viral / Q000096:biosynthesis*; D005557:Formaldehyde; D006358:Hot Temperature; D009691:Nucleic Acid Denaturation; D011830:Radiation Effects; D013936:Thymidine; D014316:Tritium; D014466:Ultraviolet Rays; D014779:Virus Replication
chemical_list: D004270:DNA, Circular; D004279:DNA, Viral; D014316:Tritium; D005557:Formaldehyde; D013936:Thymidine