Demonstration during life of rabies antigen in humans.
In three cases of human rabies, in which the diagnosis was proved postmortem, rabies antigen was detected by direct immunofluorescence of frozen sections of facial skin. The antigen was thought to be in nerve fibers in association with hair follicles. Development of this technique might enable the establishment of a method for the diagnosis of human rabies during life.
D000293:Adolescent; D000328:Adult; D000818:Animals; D000956:Antigens, Viral; D001706:Biopsy; D002648:Child; D005455:Fluorescent Antibody Technique; D005629:Frozen Sections; D006197:Hair / Q000276:immunology; D006801:Humans; D008297:Male; D051379:Mice; D009454:Neurofibrils / Q000276:immunology; D010527:Perissodactyla / Q000276:immunology; D011818:Rabies / Q000175:diagnosis / Q000276:immunology* / Q000473:pathology; D012867:Skin / Q000276:immunology / Q000473:pathology; D013552:Swine
D000956:Antigens, Viral