Chronic vulvovaginitis in children due to Shigella flexneri.
Although previous reports have implicated Shigella flexneri in resistant or chronic cases  of vulvovaginitis in children, no authors have described the clinical findings of this condition. The report presents four cases of persistent vulvovaginitis in prepubertal Indian girls from different reservation communities in Arizona. S. flexneri was isolated in pure culture from the vaginal discharge of each patient. All four cases were characterized by a prolonged vaginitis with a bloody, purulent discharge which responded poorly or not at all to various topical modes of therapy for nonspecific vaginitis. Three cases cleared completely when treated with orally given ampicillin for one week. The striking similarity of these cases suggests that chronic Shigella vulvovaginitis is a recognizable clinical entity and should be considered in the differential diagnosis of persistent vaginitis in children, especially in those from communities where Shigella is endemic.
D000667:Ampicillin / Q000627:therapeutic use; D001130:Arizona; D002648:Child; D002675:Child, Preschool; D004756:Enterobacteriaceae Infections / Q000150:complications*; D004967:Estrogens / Q000627:therapeutic use; D005260:Female; D006801:Humans; D007198:Indians, North American; D009582:Nitrofurantoin / Q000627:therapeutic use; D009761:Nystatin / Q000627:therapeutic use; D012763:Shigella flexneri / Q000472:pathogenicity; D013444:Sulfisoxazole / Q000627:therapeutic use; D013449:Sulfonamides / Q000627:therapeutic use; D014848:Vulvovaginitis / Q000175:diagnosis / Q000188:drug therapy / Q000209:etiology*
D004967:Estrogens; D013449:Sulfonamides; D009761:Nystatin; D013444:Sulfisoxazole; D000667:Ampicillin; D009582:Nitrofurantoin