Uptake, localization and secretagogic action of some biogenic amines in the submandibular and pancreatic glands of the guinea pig.
The effects of noradrenaline, 5-hydroxytryptamine (5-HT) 5-hydroxyptophan (5-HTP), dopamine, L-DOPA and carbamylcholine on the secretion of amylase from guinea pig submandibular gland and pancreas were studied. Carbamylcholine stimulated both pancreatic and salivary gland amylase release, whereas the biogenic amines elicted amylase secretion only from the submandibular gland. L-DOPA and 5-HTP, the precursor amino acids of dopamine and 5-HT, were without effects. In both glands 5-HT and dopamine were accumlated to a greater extent than their precursor amino acids. The uptake of biogenic amines into acinar cells and their effects on amylase secretion are compared and dicussed in terms of receptor specificity.
D006916:5-Hydroxytryptophan / Q000378:metabolism / Q000494:pharmacology; D000681:Amylases / Q000378:metabolism*; D000818:Animals; D001679:Biogenic Amines / Q000494:pharmacology*; D002217:Carbachol / Q000378:metabolism / Q000494:pharmacology; D004298:Dopamine / Q000378:metabolism / Q000494:pharmacology; D006168:Guinea Pigs; D007980:Levodopa / Q000378:metabolism / Q000494:pharmacology; D008297:Male; D009638:Norepinephrine / Q000378:metabolism / Q000494:pharmacology; D010179:Pancreas / Q000378:metabolism*; D012701:Serotonin / Q000378:metabolism / Q000494:pharmacology; D013363:Submandibular Gland / Q000378:metabolism*
D001679:Biogenic Amines; D012701:Serotonin; D007980:Levodopa; D002217:Carbachol; D006916:5-Hydroxytryptophan; D000681:Amylases; D004298:Dopamine; D009638:Norepinephrine