Cytotoxicity of normal rabbit serum for chicken lymphoid cells. I. Localization of the activity.
Normal rabbit sera were found to be highly cytotoxic for chicken thymus cells. When the sera were fractionated on Sephadex G-200, the natural cytotoixc activity resided exclusively in the first peak. It was found to be complement-dependent and heat stable at 56 degrees. On the other hand, in the serum of immunized animals the specific cytotoxic activity appeared in the second peak.
D000818:Animals; D002645:Chickens; D002845:Chromatography; D003601:Cytotoxicity Tests, Immunologic; D007106:Immune Sera; D011817:Rabbits; D013045:Species Specificity; D013601:T-Lymphocytes / Q000276:immunology*
D007106:Immune Sera