Multiple sclerosis and high incidence of a B lymphocyte antigen.
Multiple sclerosis patients were tested for six new antigens present on human B lymphocytes. The group 4 specificity occurred in 83.9% of the 56 patients as compared to 32.5 percent in 72 healthy controls (P less than .003). The antiserums defining the five other B lymphocyte specificities reacted at a lower frequency to B cells from multiple sclerosis patients, showing that increased reactivity to group 4 antiserum was specific. Linkage of a hypothesized multiple sclerosis susceptibility gene with certain haplotypes of HLA-A3, HLA-B7 HLA-DW2, and the new B group 4 can be inferred.
D000483:Alleles; D001402:B-Lymphocytes / Q000276:immunology*; D005796:Genes; D008040:Genetic Linkage; D006680:HLA Antigens; D006801:Humans; D007519:Isoantigens; D009103:Multiple Sclerosis / Q000175:diagnosis / Q000235:genetics / Q000276:immunology*; D044465:White People
D006680:HLA Antigens; D007519:Isoantigens