Enhanced expression of histocompatibility antigens of lymphoid cells in mice treated with interferon.
Treatment of young and mature mice with potent preparations of mouse interferon results in a marked enhancement of the expression of histocompatibility antigens on the surface of thymocytes and splenic lymphocytes, as measured by an enhanced absorption of alloantiserum. These modifications in the expression of cell surface antigens may reflect an effect of interferon on lymphocyte naturation and may be relevant to theffect of interferon on lymphocyte function.
D000818:Animals; D000937:Antigen-Antibody Reactions / Q000187:drug effects*; D001665:Binding Sites / Q000187:drug effects; D006649:Histocompatibility Antigens / Q000032:analysis*; D007106:Immune Sera; D007369:Interferon Inducers / Q000494:pharmacology; D007372:Interferons / Q000494:pharmacology*; D008214:Lymphocytes / Q000187:drug effects; D051379:Mice; D008810:Mice, Inbred C57BL; D008811:Mice, Inbred DBA; D013601:T-Lymphocytes / Q000187:drug effects
D006649:Histocompatibility Antigens; D007106:Immune Sera; D007369:Interferon Inducers; D007372:Interferons