[The genetics of the protease inhibitor system and osteospongiosis. Statistical study in 199 patients].
Since the trypsin activity of the inner ear fluid appears to be essential in the evolution of otosclerosis towards a cochlear deafness it was obvious that the protease inhibitor system which is an excellent genetic marker ought to be studied during the onset and the evolution of otosclerosis. No differences with the statistical data from the normal population was found the origin of the trypsin that destroys the inner ear is to be found locally the histiocytes of the otosclerosis focus.
D004432:Ear, Middle / Q000187:drug effects; D005602:France; D006801:Humans; D010040:Otosclerosis / Q000453:epidemiology / Q000235:genetics*; D010641:Phenotype; D011480:Protease Inhibitors; D014357:Trypsin / Q000502:physiology; D000515:alpha 1-Antitrypsin / Q000502:physiology
D011480:Protease Inhibitors; D000515:alpha 1-Antitrypsin; D014357:Trypsin
Génétique du système des inhibiteurs protéasiques et otospongiose