title: Preliminary clinical experience with meptazinol, a new analgesic.
abstract: The analgesic effect of intravenous meptazinol at various dosage levels was studied in 30 patients suffering from acute renal colic. Out of a total of 41 injections (dose range: 20 to 120 mg.) a favourable analgesic response was recorded on 39 occasions. The onset of action was rapid with the minimun duration of action of 1 hour. Higher doses increased the drug's action but were accompanied by nausea and dizziness. There was no overall effect on blood pressure or heart rate.
mesh_terms: D000208:Acute Disease; D000328:Adult; D000368:Aged; D000700:Analgesics / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D002986:Clinical Trials as Topic; D003085:Colic / Q000188:drug therapy*; D006801:Humans; D007275:Injections, Intravenous; D007674:Kidney Diseases / Q000188:drug therapy*; D008875:Middle Aged; D010865:Pilot Projects; D010919:Placebos; D014717:Vertigo / Q000139:chemically induced; D014839:Vomiting / Q000139:chemically induced
chemical_list: D000700:Analgesics; D010919:Placebos