[The influence of 1-DOPA on emotional responses and serotonin metabolism in the rat brain].
Experiments were conducted on male Wistar rats. Intraperitoneal injection of 1-DOPA (.100 - 200 mg/kg increased the brain concentration of dopamine and homovanilinic acid and lowered the level of brain serotonin, with simultaneous elevation of its metabolite 5-HIAA. A decrease in serotonin level was accompanied by increased emotional reactivity and agressiveness in rats. L-DOPA (100 mg/kg) decreased the binding of serotonin formed from tryptophane (100 mg/kg), accelerating its catabolism in the brain; at the same time 1-DOPA eliminated the depressive action of tryptophane on the emotional reactivity and aggressiveness. It is supposed that increased emotional excitation elicited by 1-DOPA was partially mediated through the block of the serotoninergic system.
D006916:5-Hydroxytryptophan / Q000378:metabolism; D000374:Aggression / Q000187:drug effects; D000818:Animals; D001921:Brain / Q000378:metabolism*; D004298:Dopamine / Q000378:metabolism; D004644:Emotions / Q000187:drug effects*; D005106:Exploratory Behavior / Q000187:drug effects; D006801:Humans; D006897:Hydroxyindoleacetic Acid / Q000378:metabolism; D007980:Levodopa / Q000494:pharmacology*; D008297:Male; D009949:Orientation / Q000187:drug effects; D051381:Rats; D012701:Serotonin / Q000378:metabolism*; D013268:Stimulation, Chemical; D014364:Tryptophan / Q000378:metabolism
D012701:Serotonin; D007980:Levodopa; D006897:Hydroxyindoleacetic Acid; D014364:Tryptophan; D006916:5-Hydroxytryptophan; D004298:Dopamine
Vliianie 1-DOFA na émbrional'nye reaktsii i obmen serotonina v mozge krys