The repair of potentially lethal damage; an alternative approach.
An alternative approach to the explanation and analysis of post-irradiation effects is presented. The analysis is based on the repair of a radiation-induced lesion and it is shown that the experimental results are compatible with the repair of one type of critical lesion involved in cell reproductive death. The nature of the lesion with respect to potentially lethal damage and sub-lethal damage is discussed.
D000818:Animals; D002470:Cell Survival / Q000528:radiation effects; D002478:Cells, Cultured; D006224:Cricetinae; D004260:DNA Repair; D004307:Dose-Response Relationship, Radiation; D004330:Drosophila / Q000528:radiation effects; D066298:In Vitro Techniques; D007739:L Cells / Q000528:radiation effects; D008099:Liver / Q000528:radiation effects; D008322:Mammals; D011832:Radiation Injuries; D012441:Saccharomyces cerevisiae