title: Changes in obsessive/compulsive patients as measured by the Leyton Inventory before and after treatment with clomipramine.
abstract: The Leyton Obsessional Inventory has been found to be a useful measure in assessing patients before and after treatment with clomipramine. Mean scores for symptoms and interference altered significantly during the course of treatment. The Leyton Obsessional Inventory, however, lacks external validation owing to the absence of some valid alternative quantification. In the absence of such external validation it seems justifiable to use the mean Leyton score diagnostically but not as a sole indication of severity or response to treatment.
mesh_terms: D002986:Clinical Trials as Topic; D002997:Clomipramine / Q000008:administration & dosage / Q000627:therapeutic use*; D003863:Depression / Q000150:complications / Q000188:drug therapy; D003984:Dibenzazepines / Q000627:therapeutic use*; D006801:Humans; D009771:Obsessive-Compulsive Disorder / Q000150:complications / Q000175:diagnosis / Q000188:drug therapy*; D010698:Phobic Disorders / Q000150:complications; D011569:Psychiatric Status Rating Scales
chemical_list: D003984:Dibenzazepines; D002997:Clomipramine