The effects of x-irradiation on collagen metabolism in rat skin.
Collagen metabolism in rat skin and the response to X-radiation are studied during three consecutive hair-cycles. Collagen biosynthesis and turnover, assessed by the hydroxylation of [U-14C]-proline, proceeds as a function of the periodic hair-growth phenomenon. A single X-radiation treatment to the skin does not affect the amino-acid composition of collagen, but reduces the proline hydroxylation capacity of the fibroblasts. The initial damage to the tissue, resulting in a reduced collagen concentration of the skin, particularly noticeable after several hair-cycles, is at least partially responsible for the delayed skin lesions after irradiation.
D000596:Amino Acids / Q000378:metabolism; D000818:Animals; D003094:Collagen / Q000378:metabolism*; D006197:Hair / Q000502:physiology; D008297:Male; D011830:Radiation Effects; D051381:Rats; D011919:Rats, Inbred Strains; D012867:Skin / Q000378:metabolism / Q000528:radiation effects*; D014965:X-Rays
D000596:Amino Acids; D003094:Collagen