The possible presence of a bursa-independent, IgM-producing system in chicks.
The number of splenic plaque-forming cells significantly increased in bursectomized chicks immunized secondarily with SRBC. Further experiments using rabbit antiserum specific to the bursa of Fabricius indicate that the different types of antibody-producing cells might be engaged in the synthesis of IgM in bursectomized chicks. The possible presence of a bursa-independent, IgM-producing system in chicks is suggested.
D000818:Animals; D000921:Antibody-Producing Cells / Q000276:immunology*; D002060:Bursa of Fabricius / Q000276:immunology*; D002470:Cell Survival; D002645:Chickens; D004912:Erythrocytes / Q000276:immunology; D006388:Hemagglutinins / Q000032:analysis; D006462:Hemolytic Plaque Technique; D007106:Immune Sera / Q000494:pharmacology; D007111:Immunity, Cellular; D007114:Immunization; D007075:Immunoglobulin M / Q000096:biosynthesis*; D007156:Immunologic Memory; D011817:Rabbits / Q000276:immunology; D012756:Sheep / Q000276:immunology; D013154:Spleen / Q000166:cytology / Q000276:immunology*
D006388:Hemagglutinins; D007106:Immune Sera; D007075:Immunoglobulin M