title: Histidine supplementation for treatment of anaemia of uraemia.
abstract: The effects of supplemental histidine on the anaemia of 16 chronically uraemic patients and 26 patients undergoing maintenance dialysis were assessed. Patients were given either L-histidine 4 g/day or placebo for a mean of 17-5 weeks in a randomized double-blind controlled study. Haemoglobin and packed cell volume increased slightly and to a similar degree in the patients on dialysis receiving placebo and histidine, but this change was statistically significant only in those on placebo. Plasma histidine rose significantly in the histidine-treated patients undergoing dialysis and decreased in the uraemic patients receiving placebo. These results suggest that supplementary L-histidine in patients with uraemia or patients undergoing maintenance dialysis does not improve anaemia.
mesh_terms: D000284:Administration, Oral; D000328:Adult; D000368:Aged; D000740:Anemia / Q000188:drug therapy* / Q000209:etiology; D001806:Blood Urea Nitrogen; D002908:Chronic Disease; D002986:Clinical Trials as Topic; D003404:Creatinine / Q000378:metabolism; D005260:Female; D006400:Hematocrit; D006454:Hemoglobins / Q000032:analysis; D006639:Histidine / Q000097:blood / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010919:Placebos; D006435:Renal Dialysis; D013739:Testosterone / Q000627:therapeutic use; D013997:Time Factors; D014511:Uremia / Q000150:complications* / Q000178:diet therapy
chemical_list: D006454:Hemoglobins; D010919:Placebos; D013739:Testosterone; D006639:Histidine; D003404:Creatinine