Modification of brain and CSF LH-RH following deafferentation.
The effect of hypothalamic deafferentation upon levels of LH-RH in brain, cerebrospinal fluid, and plasma was studied in adult male rats. Deafferentation produced a significant increase in the LH-RH concentration of third ventricular CSF (from 140.6 to 343.9 pg/microl), while there was no change in median eminence or hypothalamic content. LH-RH in the pineal gland and the posterior pituitary was also elevated by hypothalamic isolation.
D000818:Animals; D001921:Brain / Q000378:metabolism*; D002540:Cerebral Cortex / Q000378:metabolism; D007987:Gonadotropin-Releasing Hormone / Q000097:blood / Q000134:cerebrospinal fluid / Q000378:metabolism*; D007031:Hypothalamus / Q000378:metabolism / Q000502:physiology*; D008297:Male; D008473:Median Eminence / Q000378:metabolism; D009928:Organ Specificity; D010870:Pineal Gland / Q000378:metabolism; D010903:Pituitary Gland, Anterior / Q000378:metabolism; D010904:Pituitary Gland, Posterior / Q000378:metabolism; D051381:Rats
D007987:Gonadotropin-Releasing Hormone