[Immunologic competence of T- and B-lymphocytes in tolerance induced by cyclophosphamide].
A study was made of immunological competence of T- and B-lymphocytes of mice subjected to tolerogenic treatment (administration of a massive dose of sheep erythrocytes and cyclophosphamide 7 days before the experiment). The capacity of lymphocytes of tolerant mice to influence the interaction of normal T- and B-lymphocytes was also investigated. This form of tolerance was caused not by T-suppressors, but by a true deficiency of T-cells-helpers (both in the thymus and in the spleen), and partially of B-cells (in the spleen). Some lack of B-cells in the bone marrow was connected with a nonspecific action of cyclophosphamide. Cyclophosphamide is supposed to selectively eliminate cells proliferating in response to the antigen.
D000818:Animals; D000917:Antibody Formation; D001402:B-Lymphocytes / Q000276:immunology*; D003520:Cyclophosphamide / Q000276:immunology*; D007108:Immune Tolerance; D051379:Mice; D013601:T-Lymphocytes / Q000276:immunology*
D003520:Cyclophosphamide
Immunologicheskaia kompetentsiia T- i B-limfotsitov pri tolerantnosti, indutsirovannoĭ s pomoshch'iu tsiklofosfamida