Antimalarials: screening of (orally administered) silver solfonamides against Plasmodium berghei.
Orally administered silver sulfadiazine is effective against Plasmodium berghei. Attempts to synthesize an active analogue with antimalarial activity failed. Although several of the analogues were chemically stable (like silver sulfadiazine) in sodium chloride, none of the analogues were biologically active. This suggests that the antimalarial activity of silver sulfadiazine is stereo-specific.
D000284:Administration, Oral; D000818:Animals; D000962:Antimalarials / Q000008:administration & dosage / Q000627:therapeutic use; D004353:Drug Evaluation, Preclinical; D008288:Malaria / Q000188:drug therapy*; D051379:Mice; D010962:Plasmodium berghei; D012834:Silver / Q000008:administration & dosage / Q000627:therapeutic use; D013411:Sulfadiazine / Q000008:administration & dosage / Q000627:therapeutic use*; D013449:Sulfonamides / Q000627:therapeutic use
D000962:Antimalarials; D013449:Sulfonamides; D013411:Sulfadiazine; D012834:Silver