Blood--its derivatives and its problems--factor VIII.
Unfortunately, all of the problems of the hemophiliac have not been solved by the availability of concentrated factor VIII products. Patients still are faced with the crippling effects of arthritis, problems with employment, problems with ignorance (both medical and lay), and an increased risk of premature death even in a sophisticated, treatment-oriented, community (Table 3). It can only be hoped that we can solve the problems of hepatitis transmission, availability, and economics so that concentrated forms of factor VIII can be made available to all patients with hemophilia. It seems appropriate to suggest that our severely affected patients should be placed on some prophylactic programs, since this would ease most of the long-term psychologic and physical disabilities common to this disease.
D000686:Amyloidosis / Q000209:etiology; D001168:Arthritis / Q000209:etiology; D005169:Factor VIII / Q000302:isolation & purification; D006461:Hemolysis; D006467:Hemophilia A / Q000150:complications / Q000534:rehabilitation / Q000628:therapy*; D006505:Hepatitis / Q000209:etiology; D006801:Humans; D007518:Isoantibodies; D008297:Male; D065227:Transfusion Reaction
D007518:Isoantibodies; D005169:Factor VIII