Oxime derivatives of erythromycin: inhibitors of Rous sarcoma virus reverse transcriptase activity and focus formation.
Bovine adenovirus type 3 (BAV-3), strain WBR-1, quantitatively transforms hamster embryo carcass cells with a maximum efficiency of 4-7 X 10-4 p.f.u./focus-forming units (f.f.u). This frequency is signigicantly inhibited by the presence of 1-8 mM of Ca++. The transformed cells are highly tumourigenic in hamsters and possess T- and tumour-specific transplantation antigens. BAV-3 is one of the most oncogenic of the adenoviruses and an ideal model virus for the study of transformation.
D000256:Adenoviridae; D000818:Animals; D002118:Calcium / Q000494:pharmacology; D002417:Cattle; D002471:Cell Transformation, Neoplastic / Q000187:drug effects; D002478:Cells, Cultured; D006224:Cricetinae / Q000196:embryology; D005455:Fluorescent Antibody Technique; D006649:Histocompatibility Antigens / Q000032:analysis; D009368:Neoplasm Transplantation; D009374:Neoplasms, Experimental / Q000209:etiology / Q000276:immunology
D006649:Histocompatibility Antigens; D002118:Calcium