The effect of human alpha 2-macroglobulin on the restoration of humoral responsiveness in x-irradiated mice.
The effect of human alpha 2-macroglobulin on the recovery of the humoral immune response in X-irradiated mice has been assessed by measurement of antibody-forming cells in the spleen 5 days after challenge with sheep erythrocytes. The capacity of this protein to promote the recovery of immune responsiveness was variable, and appeared to be influenced by the strain and sex of the mice, and the dose of alpha2M given.
D000818:Animals; D000941:Antigens / Q000008:administration & dosage; D004305:Dose-Response Relationship, Drug; D004912:Erythrocytes / Q000276:immunology; D005260:Female; D006462:Hemolytic Plaque Technique; D006801:Humans; D007109:Immunity / Q000187:drug effects* / Q000528:radiation effects; D007274:Injections, Intraperitoneal; D008259:Macroglobulins / Q000302:isolation & purification / Q000378:metabolism*; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D011828:Radiation Chimera; D012709:Serum Albumin; D012712:Serum Globulins / Q000302:isolation & purification; D012756:Sheep; D013997:Time Factors
D000941:Antigens; D008259:Macroglobulins; D012709:Serum Albumin; D012712:Serum Globulins