Haemophilus influenzae meningitis: an evolving therapeutic regimen.
Ampicillin sodium has been the drug of choice in the treatment of Haemophilus influenzae meningitis. The development of ampicillin-resistant strains forces the clinician to focus on alternative therapies. We describe two patients in whom neutropenia was noted secondary to chloramphenicol administration, and streptomycin sulfate and sulfonamides were employed. An historical perspective summarizing the evolution of available therapeutic regimens is presented.
D000667:Ampicillin / Q000627:therapeutic use; D002701:Chloramphenicol / Q000009:adverse effects / Q000627:therapeutic use; D004359:Drug Therapy, Combination; D005260:Female; D006193:Haemophilus influenzae; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D008583:Meningitis, Haemophilus / Q000188:drug therapy*; D010403:Penicillin Resistance; D013307:Streptomycin / Q000008:administration & dosage / Q000627:therapeutic use*; D013449:Sulfonamides / Q000627:therapeutic use*; D013754:Tetracyclines / Q000627:therapeutic use
D013449:Sulfonamides; D013754:Tetracyclines; D002701:Chloramphenicol; D000667:Ampicillin; D013307:Streptomycin