[Noncoagulative catabolism of fibrinogen].
In catabolism of fibrinogen a function of Cupfer endothelial cells isolated from dog and rabbit liver tissue, was studied. In lysosomal-mitochondrial fraction of Cupfer cells and activator of plasminogen was found. Proteolytic and esterase (hydrolysis of benzoyll-agronine methyl ester) activities were the most typical for lysosomal-mitochondril and supernatant fractions of Cupfer cells. The enzymatic hydrolysis of fibrinogen was not observed in cytoplasmic matrix. The data obtained suggest that under the physiological conditions non-coagulational catabolism of fibrinogen occurred mainly intracellularly.
D000818:Animals; D001777:Blood Coagulation; D002458:Cell Fractionation; D002498:Centrifugation; D003584:Cytological Techniques; D004285:Dogs; D004727:Endothelium / Q000166:cytology; D004950:Esterases / Q000097:blood; D005340:Fibrinogen / Q000378:metabolism*; D006801:Humans; D007728:Kupffer Cells / Q000378:metabolism; D008099:Liver / Q000166:cytology; D008280:Magnetics; D010958:Plasminogen / Q000097:blood; D011817:Rabbits; D013347:Subcellular Fractions / Q000378:metabolism; D014462:Ultrafiltration
D005340:Fibrinogen; D010958:Plasminogen; D004950:Esterases
Nekoaguliatsionnyĭ katabolizm fibrinogena