[Absecence of the antidepressant action of lithium under clinical and experimental conditions].
During a long-term treatment by lihtium carbonate of 200 patients with manic-depressive psychosis the authors did not find any antidepressive effect. In some cases administration of lithium during the depressive phases aggravated the depressive symptomatology, prolonged the duration of the phase, increased the therapeutical resistance. In experiments with lithium on animals there were no typical traits for an antidepressive effect: adrenopositive and serotoninopositive action.
D006916:5-Hydroxytryptophan / Q000494:pharmacology; D000661:Amphetamine / Q000494:pharmacology; D000818:Animals; D000928:Antidepressive Agents; D001714:Bipolar Disorder / Q000188:drug therapy*; D004347:Drug Interactions; D006801:Humans; D007099:Imipramine / Q000494:pharmacology; D008094:Lithium / Q000494:pharmacology / Q000627:therapeutic use*; D051379:Mice; D009043:Motor Activity / Q000187:drug effects; D010095:Oxotremorine / Q000494:pharmacology; D010276:Parasympatholytics; D010624:Phenelzine / Q000494:pharmacology; D051381:Rats; D011930:Reaction Time; D012110:Reserpine / Q000494:pharmacology; D013566:Sympathomimetics
D000928:Antidepressive Agents; D010276:Parasympatholytics; D013566:Sympathomimetics; D010095:Oxotremorine; D012110:Reserpine; D008094:Lithium; D006916:5-Hydroxytryptophan; D000661:Amphetamine; D010624:Phenelzine; D007099:Imipramine
Otsutstvie antidepressivnogo deĭstviia litiia v klinike i éksperimente