title: Effect of 2-years' use of chlorhexidine-containing dentifrices on plaque, gingivitis, and caries.
abstract: Chlorhexidine digluconate in 0.1% and 0.4% concentrations was added to dentifrices to evaluate its effect on plaque formation, gingival conditions and caries in 73 dental students over a 2-year period. No differences were found in the Pl I and the G I indices between the active and the placebo dentifrices, but a possible effect on caries was demonstrated. Discolorations of anterior teeth and fillings were the only side effects observed.
mesh_terms: D000328:Adult; D001645:Biguanides / Q000627:therapeutic use*; D002710:Chlorhexidine / Q000009:adverse effects / Q000627:therapeutic use*; D002986:Clinical Trials as Topic; D003731:Dental Caries / Q000517:prevention & control*; D003773:Dental Plaque / Q000517:prevention & control*; D003802:Dentifrices / Q000627:therapeutic use*; D005891:Gingivitis / Q000517:prevention & control*; D006801:Humans; D008297:Male; D010919:Placebos; D013997:Time Factors; D014075:Tooth Discoloration / Q000139:chemically induced
chemical_list: D001645:Biguanides; D003802:Dentifrices; D010919:Placebos; D002710:Chlorhexidine