[Effect of slow-release aminophylline on pulmonary function in obstructive respiratory disease(author's transl)].
The effects on pulmonary function of a slow-release preparation of an oral broncholytic drug (containing 350 mg aminophylline, released over eight hours) was tested on 26 patients in a double-blind trial. There was a marked reduction of airway resistance and stimulation of breathing with decreased dynamic work of breathing. Distinctly improved alveolar function was demonstrated especially in a fall of arterial CO2 tension, but in some cases there was probably an increase in distribution abnormality. Central haemodynamic changes with a decreased in pulmonary artery pressure and changes in the other values lasted for more than ten hours on the first day of treatment, and were demonstrable on the fourth day even before the drug was taken that day. The criteria of an effective broncholytic slow-release drug with sustained effect were thus fulfilled.
D000284:Administration, Oral; D000293:Adolescent; D000328:Adult; D000368:Aged; D000628:Aminophylline / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000627:therapeutic use; D001794:Blood Pressure; D002245:Carbon Dioxide / Q000097:blood; D002986:Clinical Trials as Topic; D005260:Female; D006801:Humans; D008173:Lung Diseases, Obstructive / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged; D010313:Partial Pressure; D010919:Placebos; D011651:Pulmonary Artery; D013997:Time Factors
D010919:Placebos; D002245:Carbon Dioxide; D000628:Aminophylline
Der Einfluss eines oralen Aminophyllin-Präparates mit Retardwirkung auf die Lungenfunktionsparameter bei obstruktiven Atemwegserkrankungen