title: [Histiocytosis. Clinical aspects in childhood].
abstract: The clinical and pathologic features in 11 cases of histiocytosis were reviewed. The were 6 cases of Hand-Schüller-Christian, disease 4 cases of Letterer-Siwe and 1 case of eosinophilic granuloma. The clinical differences among those diseases are outlined. We agree with other authors that the symptoms are related in great measure to the moment of embryonic differentation in which the proliferation occurred. When proliferation is present at an early stage of development of macrophage (promonocyte), a more malignant disease appears than when it occurs at a later stage (macrophage). The treatment of histiocytosis is briefly outlined.
mesh_terms: D001706:Biopsy; D002648:Child; D002675:Child, Preschool; D003937:Diagnosis, Differential; D004803:Eosinophilic Granuloma / Q000175:diagnosis; D005260:Female; D006646:Histiocytosis, Langerhans-Cell / Q000175:diagnosis*; D006801:Humans; D008297:Male; D010372:Pediatrics
vernacular_title: Histiocitosis. Aspectos clínicos en la niñez