[Potentiation of the action of reserpine on the frog as a characteristic effect of antidepressants].
Antidepressants-thymoanaleptics chlorimipramine, amitriptyline, imipramine, melitracen potenciated the inhibitory effect of reserpine in a frog (supression of the turning over from the back reflex) stronger than did antidepressants with less marked thymoanaleptic action (Lu-5-003, azaphen, quipazine, desipramine) and also neuroleptics (promazine, stelazine, haloperidol) cholinolytics (atropine and benectyzine) and stimulator--phenamine. The potentiating action of tertiary amines--imipramine, amitriptyline protixen was stronger than that of the corresponding secondary amines (desipramine, norprotixen, nortriptyline). Phenothiazines with the chlorine atom in the second position (chlorprotixen and chlorpromazine) potentiated the effect of reserpine less intensively than did their chlorine-free analogues (protixen, promazine).
D000661:Amphetamine / Q000494:pharmacology; D000818:Animals; D000928:Antidepressive Agents / Q000494:pharmacology*; D001522:Behavior, Animal / Q000187:drug effects; D003864:Depression, Chemical; D004305:Dose-Response Relationship, Drug; D004357:Drug Synergism; D005260:Female; D008297:Male; D010276:Parasympatholytics / Q000494:pharmacology; D011896:Rana temporaria; D012018:Reflex / Q000187:drug effects; D012110:Reserpine / Q000494:pharmacology*; D012621:Seasons; D013997:Time Factors; D014149:Tranquilizing Agents / Q000494:pharmacology
D000928:Antidepressive Agents; D010276:Parasympatholytics; D014149:Tranquilizing Agents; D012110:Reserpine; D000661:Amphetamine
Potentsirovanie deĭstviia rezerpina na liagushke kak kharakternyĭ éffekt antidepressantov