Corticosteroids in organ preservation.
1. Glucocorticoids have been empirically employed during perfusion preservation of transplantable organs. 2. Use of corticosteroids in organ preservation is based on their pharmocologic binding of released lysosomal enzymes, as membrane stabilizers, peripheral vasodilators, and inhibitors of the inflammatory response. 3. The incidence post-transplant of ATN in cadaveric kidney preservation by pulsa-tile perfusion has been reduced from 57% to 18% when the donor was protected with large doses of M-P. 4. There is sufficient clinical and laboratory evidence to substantiate the use of large doses of M-P given to the prospective donor as a protective agent against ischemic injury in organ recovery.
D005938:Glucocorticoids / Q000494:pharmacology*; D016027:Heart Transplantation; D007249:Inflammation / Q000517:prevention & control; D007511:Ischemia / Q000517:prevention & control; D008099:Liver; D016040:Lung Transplantation; D008247:Lysosomes / Q000187:drug effects; D009926:Organ Preservation / Q000379:methods*; D016035:Pancreas Transplantation; D010477:Perfusion; D014021:Tissue Preservation / Q000379:methods*; D014656:Vascular Surgical Procedures; D014665:Vasodilator Agents / Q000494:pharmacology; D014680:Veins / Q000637:transplantation
D005938:Glucocorticoids; D014665:Vasodilator Agents