[The influence of cardiogreen on the albumin binding of bilirubin in the neonatal period].
The albumin-binding of bilirubin may be disturbed by pharmacologically inert substances. This is true for Cardiogreen as used for dye dilution curves. The displacement of bilirubin from its albumin-bindung, examined in vitro by Sephadex filtration, is stronger for Cardiogreen than for Gantrisin known to cause kernicterus even in mild hyperbilirubinemia. However, from differences in dosage and the pharmacokinetics of the two substances it may be concluded, that the risk of possibly causing a kernicterus by Cardiogreen is limited to only extrem cases.
D001663:Bilirubin / Q000097:blood*; D002850:Chromatography, Gel; D004396:Coloring Agents / Q000494:pharmacology*; D004395:Dye Dilution Technique; D006801:Humans; D007231:Infant, Newborn; D007647:Kernicterus / Q000139:chemically induced; D011485:Protein Binding / Q000187:drug effects; D012709:Serum Albumin / Q000378:metabolism*; D013444:Sulfisoxazole / Q000494:pharmacology
D004396:Coloring Agents; D012709:Serum Albumin; D013444:Sulfisoxazole; D001663:Bilirubin
Uber den Einflubeta des Cardiogreens auf die Albuminbindung des Bilirubins in der Neonatalperiode