title: Synaptosomes containing large agranular vesicles isolated from developing rat brain.
abstract: Using the subcellular fractionation technique the fine structure of the isolated nerve endings (synaptosomes) from the hemispheres and brain stem of the 1-day old and adult rat was examined. In the synaptosomal fractions of the brain of 1-day old rats we observed a new type of nerve endings containing predominantly large agranular vesicles about 1,000 A in diameter. After incubation with alpha-methylnoradrenaline or 5-hydroxydopamine these vesicles remained agranular. It is assumed that the new type of large vesicles represent developing synaptic vesicles.
mesh_terms: D000367:Age Factors; D000818:Animals; D000831:Animals, Newborn; D001921:Brain / Q000254:growth & development*; D001933:Brain Stem / Q000254:growth & development; D006892:Hydroxydopamines / Q000494:pharmacology; D008771:Nordefrin / Q000494:pharmacology; D051381:Rats; D013347:Subcellular Fractions; D013572:Synaptic Vesicles / Q000187:drug effects / Q000648:ultrastructure*; D013574:Synaptosomes / Q000648:ultrastructure*
chemical_list: D006892:Hydroxydopamines; D008771:Nordefrin