Hypersensitivity towards alpha-crystalline in the heterochromia syndrome.
In 4 cases of heterochromic cyclitis with cataract, 5 cases of herpetic iridocyclitis, and 5 cases of senile cataract, hypersensitivity to both alpha-crystalline and uveal pigment was investigated by lymphocyte-transformation and leukocyte-migration tests. In 3 cases of heterochromic cyclitis with cataracts, cellular hypersensitivity to alpha-crystalline was proven. Basing on these findings, the role of hypersensitivity to lens proteins in the etiology of heterochromic cyclitis is suggested.
D000941:Antigens; D002386:Cataract / Q000276:immunology*; D003459:Crystallins / Q000276:immunology*; D006801:Humans; D006967:Hypersensitivity / Q000150:complications; D008213:Lymphocyte Activation; D010860:Pigments, Biological / Q000276:immunology; D014606:Uveitis, Anterior / Q000276:immunology*
D000941:Antigens; D003459:Crystallins; D010860:Pigments, Biological