Hepatitis B antigen and systemic lupus erythematosus. False positive complement fixation due to anti-antibodies.
Sera from 22 patients with systemic lupus erythematosus (SLE) were examined for the presence of hepatitis B antigen (HBsAG) by a complement fixation (CF) test, by an immunoelectrophoretic method (counterelectrophoresis-CEP), and by radioimmunoassay (RIA). The sera from 8 patients gave positive results using CF. However, the same sera and sera from 28 additional SLE patients, when tested with CEP and RIA, were not shown to contain HBsAG.
D000042:Absorption; D000888:Antibodies, Anti-Idiotypic; D003168:Complement Fixation Tests; D003378:Counterimmunoelectrophoresis; D005189:False Positive Reactions; D006510:Hepatitis B Antibodies; D006511:Hepatitis B Antigens / Q000032:analysis*; D006801:Humans; D007106:Immune Sera; D007074:Immunoglobulin G; D008180:Lupus Erythematosus, Systemic / Q000382:microbiology*; D011863:Radioimmunoassay
D000888:Antibodies, Anti-Idiotypic; D006510:Hepatitis B Antibodies; D006511:Hepatitis B Antigens; D007106:Immune Sera; D007074:Immunoglobulin G