Detection of anti-idiotype reactive cells in the response to phosphorylcholine.
Upon immunization with phosphorylcholine (PC), BALB/c mice produce antibodies bearing mainly one idiotype which is identical to that of the TEPC 15 PC-binding myeloma protein. By coating sheep red cells (SRC) with TEPC 15 it was possible to detect anti-idiotypic plaques during the course of an immune response to PC. These plaques are detectable only after the anti-PC response has reached a peak and begun to decline. They are specific, since addition of free TEPC 15 and not MOPC 315 prevented their detection. It is suggested that such anti-idiotypic reactive cells might regulate the response to PC.
D000818:Animals; D000888:Antibodies, Anti-Idiotypic / Q000096:biosynthesis*; D000917:Antibody Formation; D002794:Choline / Q000031:analogs & derivatives*; D005260:Female; D007126:Immunoglobulin Allotypes; D007700:Kinetics; D051379:Mice; D008807:Mice, Inbred BALB C; D009194:Myeloma Proteins / Q000276:immunology; D010767:Phosphorylcholine / Q000276:immunology*
D000888:Antibodies, Anti-Idiotypic; D007126:Immunoglobulin Allotypes; D009194:Myeloma Proteins; D010767:Phosphorylcholine; D002794:Choline