Tissue levels of prostaglandin E following heterotopic rat heart allografting.
Heterotopic rat heart allografts were performed in 35 rats. At intervals after transplantation, rats were killed and tissue concentrations of immunoassayable prostaglandin E (PGE) were measured in the native heart, transplanted heart, spleen, and thymus. A significant increase in allograft PGE activity was observed at days 5 through 7, coinciding with the onset of the rejection reaction. These studies implicate PGE in the host response to allografting, but further studies are needed to determine what (if any) role prostaglandins play in the rejection reaction.
D000818:Animals; D006321:Heart / Q000033:anatomy & histology; D016027:Heart Transplantation; D009206:Myocardium / Q000032:analysis*; D009929:Organ Size; D011458:Prostaglandins E / Q000032:analysis*; D051381:Rats; D013154:Spleen / Q000032:analysis* / Q000033:anatomy & histology; D013950:Thymus Gland / Q000032:analysis* / Q000033:anatomy & histology; D013997:Time Factors; D014184:Transplantation, Homologous
D011458:Prostaglandins E