Prophylactic chemotherapy with low-dosage trimethoprim-sulfamethoxazole following acute urinary tract infections in children.
The cases of 10 children with acute and recurrent infection of the urinary tract are presented. Their ages were between 7 weeks and 9 years. Five of the children had been previously treated with a combination of sulfisoxazole, ampicillin, mandelamine and nitrofurantion and four of these children had "breakthrough" infections. When trimethoprim-sulfamethoxazole was administered twice weekly no further infections were noted in four of these five patients. The second group of five children were started on trimethoprim-sulfamethoxazole from the start of their infection and treatment was continued twice weekly for 5 to 7 months. No recurrence of infection of the urine has been detected up to the present time. It is concluded that treatment with trimethoprim-sulfamethoxazole initiated at the outset of urinary tract infection and twice weekly is a valuable drug in children, provided the organism responsible for the infection is sensitive to this agent.
D000667:Ampicillin / Q000627:therapeutic use; D001424:Bacterial Infections / Q000188:drug therapy / Q000517:prevention & control*; D002648:Child; D002675:Child, Preschool; D004338:Drug Combinations; D004341:Drug Evaluation; D004927:Escherichia coli Infections / Q000188:drug therapy; D005492:Folic Acid / Q000097:blood; D006801:Humans; D007223:Infant; D008709:Methenamine / Q000627:therapeutic use; D009582:Nitrofurantoin / Q000627:therapeutic use; D011512:Proteus Infections / Q000188:drug therapy; D012008:Recurrence; D013290:Streptococcal Infections / Q000188:drug therapy; D013420:Sulfamethoxazole / Q000008:administration & dosage* / Q000009:adverse effects / Q000627:therapeutic use; D014295:Trimethoprim / Q000008:administration & dosage* / Q000009:adverse effects / Q000627:therapeutic use*; D014552:Urinary Tract Infections / Q000188:drug therapy / Q000517:prevention & control*
D004338:Drug Combinations; D000667:Ampicillin; D009582:Nitrofurantoin; D005492:Folic Acid; D014295:Trimethoprim; D008709:Methenamine; D013420:Sulfamethoxazole