Effect of various lysosomes and endotoxin on vascular permeability in frogs and mice.
Blood-lymph permeability increasing effects of frog liver lysosomes, Escherichia coli 0111 endotoxin, bradykinin and serotonin were demonstrated in frogs with a method developed by the authors. These actions were expressed in a faster dye saturation in the lymph as compared to that of the controls. 2. The method is based on the determinations of concentration of Evans blue transported as protein-bound dye into the lymph. 3. Frog liver and polymorphonuclear leukocyte lysosomes had a capillary permeability increasing action tested by local skin response when injecting Evans blue intravenously in mice. 4. All these phenomena are similar to events described earlier in mammalian systems.
D000135:Acid Phosphatase / Q000032:analysis; D000818:Animals; D001001:Anura; D001920:Bradykinin / Q000494:pharmacology; D002199:Capillary Permeability / Q000187:drug effects*; D002403:Cathepsins / Q000032:analysis; D004396:Coloring Agents / Q000097:blood; D004731:Endotoxins / Q000494:pharmacology*; D004926:Escherichia coli; D005260:Female; D007962:Leukocytes / Q000166:cytology; D008099:Liver / Q000166:cytology; D008247:Lysosomes / Q000032:analysis / Q000201:enzymology; D008297:Male; D051379:Mice; D011485:Protein Binding; D011506:Proteins / Q000032:analysis; D011893:Rana esculenta; D012701:Serotonin / Q000494:pharmacology
D004396:Coloring Agents; D004731:Endotoxins; D011506:Proteins; D012701:Serotonin; D000135:Acid Phosphatase; D002403:Cathepsins; D001920:Bradykinin