title: Pathological mechanisms to explain some cases of amenorrhoea without organic disease.
abstract: A test is described to define the site of the lesion causing amenorrhoea in women of child-bearing age who have normal ovaries and a normal response to luteinizing hormone-releasing hormone (LH-RH). Patients able to produce a release of LH following the administration of 1 mg. of oestradiol benzoate (EB) have normal hypothalamic function and thus the site of the defect must lie more centrally in the brain. Patients unable to show these LH surges have either a primary or secondary abnormality affecting their hypothalamic oestrogen "receptor" mechanisms or their ability to produce LH-RH.
mesh_terms: D000568:Amenorrhea / Q000139:chemically induced / Q000209:etiology* / Q000503:physiopathology; D000856:Anorexia Nervosa / Q000150:complications; D003276:Contraceptives, Oral / Q000009:adverse effects; D004958:Estradiol / Q000097:blood; D005260:Female; D005640:Follicle Stimulating Hormone / Q000097:blood; D007987:Gonadotropin-Releasing Hormone / Q000494:pharmacology; D006801:Humans; D007031:Hypothalamus / Q000187:drug effects / Q000503:physiopathology*; D007986:Luteinizing Hormone / Q000097:blood / Q000378:metabolism; D011374:Progesterone / Q000097:blood; D013268:Stimulation, Chemical; D013997:Time Factors
chemical_list: D003276:Contraceptives, Oral; D007987:Gonadotropin-Releasing Hormone; D011374:Progesterone; D004958:Estradiol; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone