Kasabach-kasabach-.
Giant haemangiomas combined with a haemostasis disorder of the Kasabach-Meritt type are rare and even more rare are the problems posed during labour when vulvo-vagino-uterine sites are involved. Two cases are reported. After summary of the clinical and biochemical studies, the authors report attempts to improve the haemostasis disorder, first with heparin and then with antifibrinolytic preparations, and to improve the angiomas with antifibrinolytic preparations in the hope of stimulating intrasacular thrombosis. In particular, the obstetric and surgical problems are discussed in the context of labour. In one case the outcome of labour was successful only moderate transfusion being required, and in the other the outcome was fatal despite the use of about 100 bottles of blood in the first 24 hours. In both cases the infants were normal.
D000328:Adult; D015119:Aminocaproic Acid / Q000627:therapeutic use; D001803:Blood Transfusion; D005260:Female; D006391:Hemangioma / Q000150:complications* / Q000188:drug therapy; D006493:Heparin / Q000627:therapeutic use; D006801:Humans; D007744:Obstetric Labor Complications; D006473:Postpartum Hemorrhage / Q000401:mortality / Q000628:therapy; D011247:Pregnancy; D011250:Pregnancy Complications, Hematologic / Q000188:drug therapy; D011696:Purpura, Thrombocytopenic / Q000150:complications* / Q000188:drug therapy; D012878:Skin Neoplasms / Q000150:complications* / Q000188:drug therapy; D013577:Syndrome; D014148:Tranexamic Acid / Q000627:therapeutic use
D014148:Tranexamic Acid; D006493:Heparin; D015119:Aminocaproic Acid
Problémes pratiques posés par deux cas d'hémangiomes géants avec syndrome de Kasabach Meritt