[Interaction of various types of cells in the production of anti-influenzal antibodies. III. Cooperation of B- and T-lymphocytes in the production of antibodies to the influenza virus].
Bone marrow and thymus cells of syngenous donors were transplanted to sublethally irradiated mice to study the interaction between the B- and T-lymphocytes in the production of antibodies to the influenza virus. Influenza virus proved to be referred to the thymus-dependent antigens; both types of the lymphocytes participated in the antibody production. The T-lymphocyte function could not be replaced by an increase in the dose of the antigen and of the amount of B-lymphocytes. The ratio of the B- and T-lymphocytes optimal for the antibody production was 1:1 or 1:2.
D000818:Animals; D000914:Antibodies, Viral / Q000096:biosynthesis*; D000917:Antibody Formation / Q000528:radiation effects; D000921:Antibody-Producing Cells / Q000276:immunology*; D001402:B-Lymphocytes / Q000276:immunology* / Q000637:transplantation; D001853:Bone Marrow / Q000276:immunology; D001854:Bone Marrow Cells; D007114:Immunization; D051379:Mice; D008807:Mice, Inbred BALB C; D009975:Orthomyxoviridae / Q000276:immunology*; D011830:Radiation Effects; D011833:Radiation Injuries, Experimental / Q000276:immunology; D013154:Spleen / Q000276:immunology; D013601:T-Lymphocytes / Q000276:immunology* / Q000637:transplantation; D013950:Thymus Gland / Q000276:immunology
D000914:Antibodies, Viral
Vzaimodeĭstvie razlichnykh tipov kletok v produktsii protivo-grippoznykh antitel. Soobshchenie III. Kooperatsiia B- i T-limfotsitov v produktsii antitel k virusu grippa