[Autoimmune phenomena in D-penicillamine therapy].
In two patients with rheumatoid arthritis, immunoglobuline deposits in the skin were detected during D-penicillamine treatment. One patient presented with drug induced exanthema, the other with pemphigus erythematosus which was confirmed by clinical, histological, and immunofluorescent findings. During the development of the specific side-effect in one patient, an increase of ANA-titre and antibody-binding-capacity versus denaturated DNA was observed. Therefore in a prospective study of another ten patients during four months after onset of treatment with D-penicillamine, antinuclear antibodies and antibody-binding-capacity versus native and denaturated DNA were examined. The latter group of patients - without skin lesions - did not show any changes in the above mentioned parameters.
D000974:Antibodies, Antinuclear; D000917:Antibody Formation; D000937:Antigen-Antibody Reactions; D001172:Arthritis, Rheumatoid / Q000188:drug therapy*; D005076:Exanthema / Q000139:chemically induced; D006801:Humans; D010392:Pemphigus / Q000139:chemically induced; D010396:Penicillamine / Q000009:adverse effects* / Q000627:therapeutic use
D000974:Antibodies, Antinuclear; D010396:Penicillamine
Autoimmunologische Phänomene unter D-penicillamin-Therapie