[Studies on long-term irradiated rats using clomiphenedihydrogen citrate, LH and LH-RH].
The influence of clomiphene, LH and LH-RH on vaginal cycle and ovarian function in mature rats, which had been exposed to continuous light in order to block the cyclic sexual centre, was examined by different doses. While ovulation was obtained by administration of LH and LH-RH, clomiphene showed no effect. It may be assumed that the central mode of action of the "ovulation inducing effect" of clomiphene is mediated by stimulation of the cyclic sexual centre in the anterior hypothalamus.
D000818:Animals; D002996:Clomiphene / Q000008:administration & dosage / Q000494:pharmacology*; D003338:Corpus Luteum / Q000166:cytology; D004031:Diestrus / Q000187:drug effects; D005260:Female; D007987:Gonadotropin-Releasing Hormone / Q000008:administration & dosage / Q000494:pharmacology*; D006062:Gonadotropins / Q000378:metabolism; D007279:Injections, Subcutaneous; D008027:Light; D007986:Luteinizing Hormone / Q000008:administration & dosage / Q000494:pharmacology*; D010053:Ovary / Q000166:cytology / Q000187:drug effects*; D010060:Ovulation / Q000187:drug effects*; D011247:Pregnancy; D051381:Rats; D013268:Stimulation, Chemical; D014626:Vaginal Smears
D006062:Gonadotropins; D002996:Clomiphene; D007987:Gonadotropin-Releasing Hormone; D007986:Luteinizing Hormone
Untersuchungen mit Clomiphendihydrogencitrat, LH and LH-RH an dauerlichtbehandelten Ratten