title: Bioavailability studies and the clinical pharmacologist: correlation of drug distribution with clinical effects.
abstract: Bioavailability studies can be interpreted only when clinical information is available which correlates drug distribution with both efficacious and toxic clinical effects. The clinical pharmacologist should be instrumental in the development of safe and effective drug therapy by the systematic application of well designed clinical trials, the clear definition of therapeutically desirable clinical responses, and the development and application of improved techniques of measuring these effects.
mesh_terms: D001682:Biological Availability; D001702:Biopharmaceutics; D002986:Clinical Trials as Topic; D004305:Dose-Response Relationship, Drug; D004341:Drug Evaluation; D006801:Humans; D007700:Kinetics; D004364:Pharmaceutical Preparations / Q000097:blood; D010600:Pharmacology
chemical_list: D004364:Pharmaceutical Preparations