Cellular specificity of plasmacytoma-induced immunosuppression.
The pattern of immunodeficiency in plasmacytoma-bearing mice appears to be unique. Mice bearing these tumors exhibit a severe impairment in their ability to mount a primary immune response to thymus-dependent and -independent antigens. However, cell-mediated immune functions in these mice apparently remain intact. Thus, when T cell activity of lymph node cells from plasmacytoma-bearing mice was tested in vivo by sensitization with dinitrofluorobenzene and in vitro by responsiveness to phytohemmagglutinin, allogeneic cells, and dinitrobenzene sulfonate, cell-mediated immunity was found to be normal.
D000818:Animals; D000917:Antibody Formation; D004139:Dinitrofluorobenzene / Q000276:immunology; D007111:Immunity, Cellular; D007165:Immunosuppression Therapy; D037102:Lectins; D008198:Lymph Nodes / Q000166:cytology; D008213:Lymphocyte Activation; D051379:Mice; D008807:Mice, Inbred BALB C; D008810:Mice, Inbred C57BL; D010954:Plasmacytoma / Q000276:immunology*; D013601:T-Lymphocytes / Q000276:immunology
D037102:Lectins; D004139:Dinitrofluorobenzene