Platelet heparin-neutralizing factor (platelet factor 4).
The heparin-neutralizing platelet factor (PF4) is released from platelets under the influence of inducers of aggregation and nucleotide-release in the form of a high-molecular weight complex. The heparin-neutralizing activity is carried by a basic protein of molecular weight 29,700, four of which combine with a proteoglycan carrier, which in turn consists of 4 chondroitin sulfate A residues and a peptide moiety.
D000818:Animals; D001779:Blood Coagulation Factors / Q000032:analysis; D001792:Blood Platelets / Q000032:analysis; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D006494:Heparin Antagonists; D006801:Humans; D008970:Molecular Weight; D009940:Organoids / Q000032:analysis; D010974:Platelet Aggregation; D011487:Protein Conformation; D051381:Rats
D001779:Blood Coagulation Factors; D006494:Heparin Antagonists