Liver cirrhosis: immunofluorescence and biochemical studies demonstrate two types of collagen.
Pepsin solubilization of small and large noduled liver cirrhosis yielded two types of collagen (precipitated at 1.7 and 2.5 M NaCl concentrations) as demonstrated by electronmicroscopy. The 1.7 M NaCl precipitate was identified as type III collagen using an immunofluorescence technique. The 2.5 M NaCl precipitate appeared to be type I in the electronmicroscope. However, immunofluorescent and biochemical studies indicated that it was not type I but a type of collagen not yet described.
D000368:Aged; D011232:Chemical Precipitation; D003094:Collagen / Q000032:analysis* / Q000276:immunology; D005260:Female; D005455:Fluorescent Antibody Technique; D006801:Humans; D008103:Liver Cirrhosis / Q000276:immunology* / Q000378:metabolism / Q000473:pathology; D008297:Male; D008854:Microscopy, Electron; D008875:Middle Aged; D008968:Molecular Conformation; D010434:Pepsin A / Q000032:analysis
D003094:Collagen; D010434:Pepsin A