[Antibodies against various nuclear antigens (especially DNA and RNA proteins) in disseminated lupus erythematosus with and without kidney involvement and in other collagen diseases. Preliminary report].
The incidence of autoantibodies to various nuclear antigens was studied in 64 patients with SLE, 137 patients with various connective tissue diseases, 63 other patients and 90 controls. A positive correlation was found between SLE, nephritis, and the presence of antibody against native DNA. Antibody to denatured DNA showed no specificity for SLE and was correlated with the absence of nephritis. Antibody to RNA-protein occurred mainly in SLE, regardless of the presence or absence of nephritis.
D000974:Antibodies, Antinuclear; D003095:Collagen Diseases / Q000276:immunology*; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000150:complications / Q000276:immunology*; D009393:Nephritis / Q000209:etiology / Q000276:immunology
D000974:Antibodies, Antinuclear
Anticorps contre différents antigènes nucléaires (notamment DNA et RNA-protéine) dans le lupus érythémateux disséminé avec et sans atteinte rénale et dans les autres maladies du collagène