[Double-blind polycentric study of the action of S-adenosylmethionine in hepatic cirrhosis].
Two comparable groups of patients with hepatic cirrhosis of different genesis in a compensation phase have been treated for 30 days with S-adenosylmethionine and vitamine B-12 (28 cases) or with vitamine B-12 alone (25 cases). The drugs were given by slow intravenous route at the daily dose of 150 mg of SAMe and 2000 gamma of vit. B-12 or of 2000 gamma of vit. B-12 alone, in two adminstrations. An evaluation of the results was carried out mostly on the laboratory data testing the liver function. Only the group of patients who had received SAMe showed significant modifications of all the parameters considered. This is confirming SAMe ability to restore hepatocyte activity bringing also to normal the protein synthesis.
D000368:Aged; D001798:Blood Proteins / Q000032:analysis; D002986:Clinical Trials as Topic; D005260:Female; D006801:Humans; D008099:Liver / Q000378:metabolism; D008103:Liver Cirrhosis / Q000188:drug therapy*; D008111:Liver Function Tests; D008297:Male; D008875:Middle Aged; D014176:Protein Biosynthesis; D012436:S-Adenosylmethionine / Q000627:therapeutic use*; D014805:Vitamin B 12 / Q000627:therapeutic use
D001798:Blood Proteins; D012436:S-Adenosylmethionine; D014805:Vitamin B 12
Studio policentrico in doppio cieco sull'azione della solfoadenosilmetionina nella cirrosi epatica