title: Radioligand assay in reproductive biology.
abstract: Radioligand assays have been developed for the principal reproductive steroids and peptide hormones. Specific binding reagents have included antibodies, plasma binders, and intracellular receptors. In each assay, problems of specificity, sensitivity, and nonspecific inhibitors were encountered. Many features of the endocrine physiology in childhood, during puberty, and in adulthood have been characterized. Hormonal evaluations of endocrine disorders of reproduction are characterized on the basis of their characteristic pathophysiologic alterations.
mesh_terms: D000328:Adult; D000568:Amenorrhea / Q000097:blood; D002648:Child; D003117:Color Vision Defects / Q000097:blood; D012734:Disorders of Sex Development / Q000097:blood / Q000235:genetics; D004958:Estradiol / Q000097:blood; D005058:Eunuchism / Q000097:blood; D005260:Female; D005640:Follicle Stimulating Hormone / Q000097:blood* / Q000652:urine; D012739:Gonadal Steroid Hormones / Q000097:blood*; D006177:Gynecomastia / Q000097:blood; D006801:Humans; D007006:Hypogonadism / Q000097:blood; D008607:Intellectual Disability / Q000097:blood; D007713:Klinefelter Syndrome / Q000097:blood; D007986:Luteinizing Hormone / Q000097:blood*; D008297:Male; D009223:Myotonic Dystrophy / Q000097:blood; D009839:Oligomenorrhea / Q000097:blood; D010053:Ovary / Q000502:physiology; D011374:Progesterone / Q000097:blood; D011869:Radioligand Assay / Q000379:methods; D013577:Syndrome; D013737:Testis / Q000502:physiology; D013739:Testosterone / Q000097:blood
chemical_list: D012739:Gonadal Steroid Hormones; D013739:Testosterone; D011374:Progesterone; D004958:Estradiol; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone