title: [Thrombosis of the Björk-Shiley valve as an early fatal complication of the prothetic aortic valve replacement (author's transl)].
abstract: From a series of 28 patients subjected to aortic valve replacement with the Björk-Shiley tilting disc valve prosthesis 3 cases are reported in which massive thrombosis with valve dysfunction and fatal outcome occurred in the very early postoperative period. The autopsy findings and the examination of the blood coagulation state during the first 24 hours postoperatively disclosed in all 3 cases a hypercoagulability being responsible for the massive clot formation. The early recognition and establishment of the diagnosis of a hypercoagulability state and an immediate anticoagulant therapy with heparin are necessary for preventing such early fatal complications in patients with cardiac valve replacement.
mesh_terms: D000328:Adult; D000368:Aged; D001021:Aortic Valve / Q000601:surgery*; D001344:Autopsy; D001778:Blood Coagulation Disorders / Q000175:diagnosis / Q000517:prevention & control; D006350:Heart Valve Prosthesis / Q000009:adverse effects*; D006493:Heparin / Q000627:therapeutic use; D006801:Humans; D008297:Male; D011182:Postoperative Care; D011183:Postoperative Complications / Q000517:prevention & control; D011474:Prosthesis Design; D013927:Thrombosis / Q000209:etiology* / Q000517:prevention & control; D013997:Time Factors
chemical_list: D006493:Heparin
vernacular_title: Lokale Gerinnselbildung am Björk-Shiley-Ventil als Frühkomplikation des prothetischen Aortenklappenersatzes