title: An in vivo study of an antimicrobial mouth rinse on supragingival and subgingival plaque and calculus formation.
abstract: An antibiotic mouth rinse (CC10232) was used twice a day for one week in human subjects in a supervised double blind clinical and histological study. Nylon strips were placed supra and subgingivally for one week and then sectioned, stained and examined. Results showed that the rinse containing CC-10232 reduced the amount of plaque and reduced the amount of mineralization in 4 of 5 subjects.Also, no spirochetes were found in subjects who utilized this rinse.
mesh_terms: D000891:Anti-Infective Agents, Local / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects / Q000302:isolation & purification / Q000648:ultrastructure; D002986:Clinical Trials as Topic; D003728:Dental Calculus / Q000382:microbiology* / Q000473:pathology; D003773:Dental Plaque / Q000382:microbiology* / Q000473:pathology; D006801:Humans; D009067:Mouthwashes / Q000494:pharmacology*; D010919:Placebos; D013142:Spirochaeta / Q000302:isolation & purification
chemical_list: D000891:Anti-Infective Agents, Local; D009067:Mouthwashes; D010919:Placebos