Studies on the inhibitory effect of somatostatin on glucose induced insulin release in the isolated perfused rat pancreas.
Somatostatin, the recently discovered growth hormone release-inhibiting hormone in the hypothalamus, also inhibited glucose induced insulin release from the isolated perfused rat pancreas. The lowest effective dose of somatostatin was 1 ng/ml of perfusate. By increasing the dose to 100 ng/ml an almost complete inhibition of basal as well as stimulated insulin release was obtained. The inhibition of glucose stimulated insulin release mediated by somatostatin might be of competitive nature since somatostatin seemed to dislocate the glucose-insulin dose-response curve to the right.
D000818:Animals; D001667:Binding, Competitive; D003864:Depression, Chemical; D004305:Dose-Response Relationship, Drug; D005947:Glucose / Q000494:pharmacology*; D013007:Growth Hormone-Releasing Hormone / Q000037:antagonists & inhibitors*; D007328:Insulin / Q000378:metabolism*; D000078790:Insulin Secretion; D010179:Pancreas / Q000187:drug effects* / Q000378:metabolism; D010455:Peptides / Q000494:pharmacology*; D010477:Perfusion; D051381:Rats; D013268:Stimulation, Chemical; D013997:Time Factors
D007328:Insulin; D010455:Peptides; D013007:Growth Hormone-Releasing Hormone; D005947:Glucose