Effects of red cell extract on in vitro growth and multiplication of malarial parasites.
An extract of red blood cells was prepared from monkey blood. Red cell extract (RCE) of Aotus monkeys was beneficial for the in-vitro cultivation of 2 strains of P. falciparum. The active material(s) in Aotus RCE was not sedimented by centrifugation at 34,800 g for 1 hr. Rhesus monkey RCE improved the growth of P. knowlesi for in-vitro cultivation through 4 schizogonous cycles (88 hr).
D000818:Animals; D001029:Aotus trivirgatus; D003470:Culture Media; D004912:Erythrocytes / Q000469:parasitology; D010961:Plasmodium / Q000254:growth & development*; D010963:Plasmodium falciparum / Q000254:growth & development; D014020:Tissue Extracts / Q000494:pharmacology*
D003470:Culture Media; D014020:Tissue Extracts