title: Replicating circular DNA molecules in yeast.
abstract: The yeast Saccharomyces cerevisiae contains a class of small circular DNA molecules, approximately 2 mum in contour length (Sinclair et al., 1967). In this report, it is shown that these molecules replicate as double-branched circles, similar to those observed during replication of the bacteriophage lambda and Escherichia coli chromosomes. A normal rate of replication of these DNA circles requires the function of a nuclear gene, cdc 8.
mesh_terms: D002499:Centrifugation, Density Gradient; D004261:DNA Replication; D004270:DNA, Circular / Q000096:biosynthesis; D005456:Fluorescent Dyes; D005796:Genes; D008854:Microscopy, Electron; D009690:Nucleic Acid Conformation; D012441:Saccharomyces cerevisiae / Q000378:metabolism*
chemical_list: D004270:DNA, Circular; D005456:Fluorescent Dyes