In vitro estrone-estradiol-17beta interconversion in the cornea, lens, iris and retina of the rabbit eye.
Estrone and estradiol-17beta were incubated with various eye tissues of female rabbits. The interconversion of both estrogenes by the action of 17beta-hydroxysteroid dehydrogenase decreased in the sequence cornea, iris, retina, and lens. In a smaller yield estradiol-17alpha was also formed from estrone. The cornea seems to be an active estrogen-metabolizing tissue. The role of estrogens and progestogens in the tissues of the anterior eye segment is briefly discussed.
D000818:Animals; D003276:Contraceptives, Oral / Q000009:adverse effects / Q000378:metabolism; D003315:Cornea / Q000378:metabolism; D004958:Estradiol / Q000378:metabolism*; D004970:Estrone / Q000378:metabolism*; D005123:Eye / Q000378:metabolism*; D005260:Female; D007498:Iris / Q000378:metabolism; D007908:Lens, Crystalline / Q000378:metabolism; D011817:Rabbits; D012160:Retina / Q000378:metabolism
D003276:Contraceptives, Oral; D004970:Estrone; D004958:Estradiol