[Lesion of the retinal fatty acids following intravitreal injection of iron. An experimental study on the retinal lesions in cases of siderosis bulbi (author's transl)].
In this study the alterations of the pattern of the fatty acids of the retinal phosphatides after intravitreal injection of ferrous ammonium sulphate are treated. In vitro and in vivo a significant decrease of the highly unsaturated fatty acids of the C22 type occurs. This lesion spreads from the region of direct contact between iron and retina towards the periphery within 24 hs. The reliability of the experiment is ensured by the proof of analogous changes in human globes affected with siderosis. Finally, the production of lipid peroxides as a cause of the breakdown of the retinal function is discussed.
D000818:Animals; D005227:Fatty Acids / Q000032:analysis / Q000378:metabolism*; D005231:Fatty Acids, Unsaturated / Q000378:metabolism; D006801:Humans; D066298:In Vitro Techniques; D007501:Iron; D008875:Middle Aged; D010743:Phospholipids / Q000032:analysis / Q000378:metabolism*; D011817:Rabbits; D012160:Retina / Q000032:analysis; D012164:Retinal Diseases / Q000139:chemically induced / Q000378:metabolism*; D012806:Siderosis / Q000378:metabolism*; D013997:Time Factors; D014822:Vitreous Body / Q000378:metabolism
D005227:Fatty Acids; D005231:Fatty Acids, Unsaturated; D010743:Phospholipids; D007501:Iron
Uber die Schädigung des retinalen Fettsäuremusters nach intravitrealer Eiseninjektion. Eine experimentelle Studie über die Netzhautveränderungen bei Siderosis bulbi