title: Etorphine in man. I. Subjective effects and suppression of morphine abstinence.
abstract: The effects of etorphine, a potent morphine-like drug, were qualitatively and quantitatively compared to those of morphine. In nondependent subjects, etorphine in doses of 0.025, 0.050, and 0.100 mg produced pupillary constriction and morphine-like subjective effects and euphoria. Etorphine was 500 times as potent as morphine, with a very rapid onset and short duration of action. In morphine-dependent subjects, etorphine suppressed abstinence but for a shorter period than morphine. These studies indicate that in man etorphine is a morphine-like drug with a high abuse potential.
mesh_terms: D002986:Clinical Trials as Topic; D005059:Euphoria / Q000187:drug effects; D006801:Humans; D009019:Morphinans / Q000494:pharmacology*; D009021:Morphine Dependence / Q000503:physiopathology*; D009294:Narcotics / Q000494:pharmacology; D000439:Pentanols / Q000494:pharmacology; D010555:Personality Inventory; D010919:Placebos; D011680:Pupil / Q000187:drug effects; D013329:Structure-Activity Relationship; D013375:Substance Withdrawal Syndrome; D011795:Surveys and Questionnaires; D013997:Time Factors
chemical_list: D009019:Morphinans; D009294:Narcotics; D000439:Pentanols; D010919:Placebos