5-Fluorocytosine treatment of candidiasis on a patient receiving regular hemodialysis.
A patient developed a severe urinary infection with Candida albicans following a cadaveric renal transplant operation. It was necessary to remove the graft and return the patient to regular hemodialysis treatment. The fungi infection was successfully eradicated by a single oral dose of 5-Fluorocytosine (20 mg/kg) after each dialysis treatment. Pharmacokinetic studies revealed that the drug had a dialyzate clearance ratio of 0.66 when compared with creatinine; the drug was not metabolized and there was no other route of elimination.
D000328:Adult; D002177:Candidiasis / Q000188:drug therapy*; D003596:Cytosine / Q000031:analogs & derivatives*; D005437:Flucytosine / Q000008:administration & dosage / Q000378:metabolism / Q000627:therapeutic use*; D006801:Humans; D016030:Kidney Transplantation; D008297:Male; D011183:Postoperative Complications; D006435:Renal Dialysis; D014184:Transplantation, Homologous; D014548:Urinary Fistula / Q000150:complications; D014552:Urinary Tract Infections / Q000188:drug therapy*
D003596:Cytosine; D005437:Flucytosine