[Experimental pulmonary edema: pathophysiological mechanism (author's transl)].
Traumaticed tissue or organs show different reactions to oral and parenteral application of watery solutions. Tissue traumaticed or not does incline to edema. 2. In its central position in blood circulation, its capability of water storage and distribution as well in its regulatory function of the cardiac output, the lung is very suitable for transportation of fluid. 3. If physiologic transportation exceeds a maximum (renal and cardiac insufficiency, high temperature, infusion) and if lymphatics are blocked, edema results in the interstitial and intraalveolare space. 4. Fatal edema is prevented during the first 48 h by applicating proteinase inhibitor drug; Trasylol immediatly after trauma. 5. Edema is significantly diminished applicating Benzopyrone (Venalot), as proven biochemically and electromicroscopically. 6. Taking the findings, it is necessary to considerate a new concept of fluid therapy.
D000818:Animals; D007611:Aprotinin / Q000627:therapeutic use; D002302:Cardiac Output; D003288:Contusions; D003374:Coumarins / Q000627:therapeutic use; D005260:Female; D008297:Male; D008854:Microscopy, Electron; D011654:Pulmonary Edema / Q000209:etiology / Q000503:physiopathology* / Q000517:prevention & control; D051381:Rats; D013898:Thoracic Injuries / Q000150:complications
D003374:Coumarins; D007611:Aprotinin
Experimentelle Untersuchungen zur Pathophysiologie der Flüssigkeitslunge