[Study of the effect of the enzyme hyaluronidase on the pathomorphological changes in certain internal organs in white mice infected intraperitoneally with Tr. vaginalis].
The authors injected daily a dose of 5 l hyaluronidase diluted in 0,5 ml of saline, in 25 out of 50 white mice, contaminated with tr. vaginalis intraperitonealy. The remaining 25 mice formed the control group and were injected only with saline. The administration was made intraperitonealy. An equal number of mice from both groups were killed on the 30th and 40th day of contamination and the macroscopic changes in the abdominal cavity were examined. Histological examinations of liver, spleen and kidneys were made as well. The obtained pathologic changes were characteristic of manifestations of chronice en pusforming inflammatory process, involving mostly liver. Substantially differences in character and gravity of the pathologic changes between mice treated with hyaluronidase and those of the control group were not found.
D000686:Amyloidosis / Q000209:etiology / Q000473:pathology; D000818:Animals; D006821:Hyaluronoglucosaminidase / Q000494:pharmacology*; D007274:Injections, Intraperitoneal; D008099:Liver / Q000473:pathology; D051379:Mice; D009336:Necrosis; D013154:Spleen / Q000473:pathology; D013997:Time Factors; D014245:Trichomonas Infections / Q000188:drug therapy / Q000473:pathology*; D014246:Trichomonas vaginalis / Q000472:pathogenicity*
D006821:Hyaluronoglucosaminidase
Prouchvane vliianieto na fermenta khialuronidaza vurkhu patomorfologichnite izmeneniia na miakoi vutreshni organi u beli mishki, zarazeni intraperitonealno s Tr. vaginalis