Sunscreen dermatitis due to glyceryl PABA: significance of cross-reactions to this PABA Ester.
Glyceryl PABA (Escalol 106), present in many popular sunscreens, is a common sensitizer which invariably cross-reacts with benzocaine; it is present in over 400 over-the-counter products. Glyceryl PABA does not appear to cross-react with the sunscreening agents amyl (Escalol 506) and octyl (Escalol 507) dimethyl PABA. Glyceryl PABA, may, on occasion, cross-react with para-aminobenzoic acid (PABA), paraphenylenediamine, aniline, and sulfa drugs. Ironically, the sunscreening agent glyceryl PABA may, itself, act as a photosensitizing agent.
D010129:4-Aminobenzoic Acid / Q000009:adverse effects* / Q000276:immunology; D062365:Aminobenzoates; D001566:Benzocaine / Q000276:immunology; D003429:Cross Reactions; D003877:Dermatitis, Contact / Q000209:etiology*; D005990:Glycerol / Q000009:adverse effects; D006801:Humans; D013473:Sunscreening Agents / Q000009:adverse effects*; D062366:para-Aminobenzoates
D062365:Aminobenzoates; D013473:Sunscreening Agents; D062366:para-Aminobenzoates; C014011:2,3-dihydroxypropyl 4-aminobenzoate; D005990:Glycerol; D010129:4-Aminobenzoic Acid; D001566:Benzocaine