Ara-A and IDU therapy of human superficial herpetic keratitis.
Ara-A ointment was compared to IDU ointment in patients with dendritic herpes simplex virus infection of the corneal epithelium. Twenty-eight patients were treated with Ara-A ointment and twenty-four with IDU ointment. The lesions healed in 5.1 days with Ara-A and in 6.9 days with IDU. This drug was given in a double-controlled manner, so that neither the patient, nor the investigator knew which drug the patient was receiving. The patient groups were comparable as to length of the dendritic lesion and duration of symptoms. The adverse reactions to each of these drugs were comparable and in no case was there any permanent ocular change from drug use.
D002986:Clinical Trials as Topic; D003320:Corneal Ulcer / Q000188:drug therapy / Q000473:pathology; D005901:Glaucoma / Q000139:chemically induced; D006801:Humans; D007065:Idoxuridine / Q000009:adverse effects / Q000627:therapeutic use*; D007634:Keratitis / Q000139:chemically induced; D007635:Keratitis, Dendritic / Q000188:drug therapy* / Q000473:pathology; D011684:Purine Nucleosides / Q000627:therapeutic use*; D012008:Recurrence; D014605:Uveitis / Q000139:chemically induced; D014740:Vidarabine / Q000009:adverse effects / Q000627:therapeutic use*; D014945:Wound Healing
D011684:Purine Nucleosides; D014740:Vidarabine; D007065:Idoxuridine