title: Alteration of bone marrow-thymus cell synergism in hereditary asplenic and adult splenctomiced mice.
abstract: The cooperation betweeen bone marrow (B) and thymus (T) cells was markedly impaired in mice with congenital asplenia.  The deficiency of IgM producers could not be corrected by neotal transplantation of spleen cells.  The use of T and B cells from splenectomized donors resulted in a marked shift from 19S to 7S antibody forming cells.
mesh_terms: D000818:Animals; D000831:Animals, Newborn; D000917:Antibody Formation; D000921:Antibody-Producing Cells / Q000276:immunology; D001402:B-Lymphocytes / Q000276:immunology* / Q000528:radiation effects; D001853:Bone Marrow / Q000276:immunology* / Q000528:radiation effects; D001854:Bone Marrow Cells; D006462:Hemolytic Plaque Technique; D007075:Immunoglobulin M / Q000096:biosynthesis; D008214:Lymphocytes; D051379:Mice; D011830:Radiation Effects; D013154:Spleen / Q000166:cytology / Q000637:transplantation; D013156:Splenectomy; D013601:T-Lymphocytes / Q000276:immunology* / Q000528:radiation effects; D014184:Transplantation, Homologous
chemical_list: D007075:Immunoglobulin M