Alleviating agitation, apprehension, and related symptoms in geriatric patients: A double-blind comparison of a phenothiazine and a benzodiazepien.
A four-week, double-blind study compared the effectiveness of thioridazine and diazepam in 40 geriatric patients with various symptoms of senility. Patients' progress was evaluated with the Hamilton Anxiety Rating Scale, a Modified Nurses' Observation Scale for Inpatient Evaluation (NOSIE), a global rating of degree of illness, and a global rating of degree of overall change. The data indicate that thioridazine was superior to diazepam inrelieving troublesome symptoms of senility.
D000368:Aged; D001007:Anxiety / Q000187:drug effects*; D002986:Clinical Trials as Topic; D003704:Dementia / Q000188:drug therapy*; D003863:Depression / Q000188:drug therapy; D003975:Diazepam / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D004341:Drug Evaluation; D005260:Female; D006801:Humans; D008297:Male; D009735:Nursing Homes; D011569:Psychiatric Status Rating Scales; D012893:Sleep Wake Disorders / Q000188:drug therapy; D013881:Thioridazine / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*
D013881:Thioridazine; D003975:Diazepam