[Electrophysiologic study of fenoxedil chlorhydrate].
Electrophysiologic studies were carried out on 10 patients before and during therapy by Fenoxedil Chlorhydrate a new anti-arrhythmic drug, to determine the effects on cardiac conduction. Fenoxedil Chlorhydrate produces a constant alteration of intra-nodal conduction. Modification of sinus function are less evident. Auricular and ventricular refractory periods are increased in the majority of cases. These results give a better understanding of mecanism of this drug, and helps in its prescription in clinical practice.
D000889:Anti-Arrhythmia Agents / Q000494:pharmacology / Q000627:therapeutic use*; D001145:Arrhythmias, Cardiac / Q000188:drug therapy* / Q000503:physiopathology; D001283:Atrioventricular Node / Q000187:drug effects / Q000503:physiopathology; D002036:Bundle of His / Q000503:physiopathology; D004562:Electrocardiography; D005260:Female; D006327:Heart Block / Q000503:physiopathology; D006329:Heart Conduction System / Q000187:drug effects*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010647:Phenyl Ethers / Q000494:pharmacology / Q000627:therapeutic use*
D000889:Anti-Arrhythmia Agents; D010647:Phenyl Ethers; C010726:fenoxedil
Etude electrophysiologique du chlorhydrate de fenoxedil