[Study of the monoaminergic mechanisms of the effect of haloperidol in experiments using cats].
Monoaminergic mechanisms of the haloperidol action on the systems "rewards" and "punishments" were studied in 22 cats with nichrome electrodes implanted into the hypothalamus. Haloperidol was introduced against the background of the dopaminomimetic amantadine, precursors of biogenic amines L-DOPA, tryptophan and 5-OTP. The inhibitory influence of haloperidol on the system "rewards" was found to be materialized largely at the expense of its serotonin-negative effect, while in the activating action of haloperidol on the system "punishment" its serotonin- and dopamino-negative effects partook.
D006916:5-Hydroxytryptophan / Q000494:pharmacology; D000547:Amantadine / Q000037:antagonists & inhibitors / Q000494:pharmacology; D000818:Animals; D001921:Brain / Q000187:drug effects*; D002415:Cats; D003864:Depression, Chemical; D004305:Dose-Response Relationship, Drug; D004336:Drug Antagonism; D004558:Electric Stimulation; D006220:Haloperidol / Q000008:administration & dosage / Q000494:pharmacology*; D007031:Hypothalamus / Q000502:physiology; D007980:Levodopa / Q000494:pharmacology; D009043:Motor Activity / Q000187:drug effects; D013268:Stimulation, Chemical; D014364:Tryptophan / Q000494:pharmacology
D007980:Levodopa; D014364:Tryptophan; D000547:Amantadine; D006916:5-Hydroxytryptophan; D006220:Haloperidol
Izuchenie monoaminergicheskikh mekhanizmov deĭstviia galoperidola, v opytakh na koshkakh.