title: Prophylactic antibiotic therapy in surgery.
abstract: Prophylactic (preventive) antibiotic therapy initiated preoperatively, with antibiotics administered in moderately high dosage for short periods, is recommended on the basis of experimental and prospective, randomized clinical trials for patients who require surgery that is likely to expose tissue planes to contamination. The value of prophylactic antibiotics in clean operations is not presently supported but must be considered in patients with decreased resistance and in those in whom infection of a prosthesis would have catastrophic results. In these patients topical antibiotics might prove useful and less dangerous. It is clear that surgical technique remains an important but as yet unmeasured factor in wound infection.
mesh_terms: D000667:Ampicillin / Q000627:therapeutic use; D000818:Animals; D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D002509:Cephaloridine / Q000627:therapeutic use; D002701:Chloramphenicol / Q000627:therapeutic use; D004927:Escherichia coli Infections / Q000517:prevention & control; D006168:Guinea Pigs; D006801:Humans; D007165:Immunosuppression Therapy; D008712:Methicillin / Q000627:therapeutic use; D009355:Neomycin / Q000627:therapeutic use; D010400:Penicillin G / Q000627:therapeutic use; D011300:Preoperative Care; D019736:Prostheses and Implants; D012306:Risk; D013203:Staphylococcal Infections / Q000517:prevention & control; D013530:Surgical Wound Infection / Q000517:prevention & control*; D013752:Tetracycline / Q000627:therapeutic use
chemical_list: D000900:Anti-Bacterial Agents; D002701:Chloramphenicol; D000667:Ampicillin; D013752:Tetracycline; D009355:Neomycin; D002509:Cephaloridine; D010400:Penicillin G; D008712:Methicillin