[Model and the experimental therapy of acute increase of intraocular pressure (author's transl)].
Comparative experiments were carried out on 63 rabbits to study the acute increase in intraocular pressure which develops in the eye after introduction of prostaglandin F2 (instillations, subconjunctival injections) and other substances (hypertonic solution of sodium chloride, and reopirin). Tonometry, tonography, and radioisotope studies of aqueous humor (24Na, albumin-labeled 131I) were done. Differences in the display and mechanisms of acute increase of intraocular pressure were marked following administration of prostaglandin and a hypertonic solution of sodium chloride. It is stated that prostaglandin increases the permeability of the blood-aqueous humor barrier for the 24Na ions in comparison with hypertonic solution of sodium chloride, and that the eye, under the influence of prostaglandin, heightens intraocular pressure. Pretreatment with dizinon (etamsilat) reduces the increase in intraocular pressure caused by prostaglandin.
D000632:Aminopyrine / Q000494:pharmacology; D000818:Animals; D001082:Aqueous Humor / Q000378:metabolism; D001692:Biological Transport / Q000187:drug effects; D004195:Disease Models, Animal; D004338:Drug Combinations; D004979:Ethamsylate / Q000627:therapeutic use; D005260:Female; D005901:Glaucoma / Q000139:chemically induced* / Q000188:drug therapy; D007429:Intraocular Pressure / Q000187:drug effects*; D008297:Male; D010653:Phenylbutazone / Q000494:pharmacology; D011460:Prostaglandins F / Q000494:pharmacology*; D011817:Rabbits; D012462:Saline Solution, Hypertonic
D004338:Drug Combinations; D011460:Prostaglandins F; D012462:Saline Solution, Hypertonic; D000632:Aminopyrine; D004979:Ethamsylate; D010653:Phenylbutazone
Modell und experimentelle Therapie akuter Steigerungen des intraokularen Druckes