title: The relationship of autoantibodies to depression of cell-mediated immunity in infectious mononucleosis.
abstract: It has been postulated that autoantibody formation occurs as a consequence of a depression of function of certain thymus-derived lymphocytes (T cells). We have examined cell-mediated immunity, a T-cell function, in infectious mononucleosis, a condition in which autoantibodies are known to develop. We have shown some evidence of depressed cell-mediated immunity in patients with infectious mononucleosis but have been unable to correlate this with autoantibody production. These results do not support the hypothesis that depression of T-cell function leads to autoantibody formation.
mesh_terms: D000974:Antibodies, Antinuclear / Q000032:analysis; D001323:Autoantibodies; D006680:HLA Antigens / Q000032:analysis; D006801:Humans; D007111:Immunity, Cellular; D007244:Infectious Mononucleosis / Q000276:immunology*; D037102:Lectins / Q000494:pharmacology; D008213:Lymphocyte Activation; D012217:Rheumatoid Factor / Q000032:analysis; D012882:Skin Tests
chemical_list: D000974:Antibodies, Antinuclear; D001323:Autoantibodies; D006680:HLA Antigens; D037102:Lectins; D012217:Rheumatoid Factor