Serum antibodies in human pancreatic disease.
An immunofluorescent study of sera from patients with various pancreatic diseases and from controls was carried out using human pancreas as substrate. A reproducible pattern of immunofluorscence, consisting of a coarse granular appearance in the cytoplasm of acinar cells of the pancreas and independent of the ABO blood group system was found. This occurred in 21 of 61 patients with acute pancreatitis; it was not found in other pancreatic diseases, and occurred in only four of 170 control subjects consisting of mixed hospital patients and healthy adults. Preliminary absorption experiments suggest that the  antigen is located in the microsomal fraction of pancreatic homogenates and may be organ-specific. The relationship of positive antibody tests to aetiological factors is discussed.
D000017:ABO Blood-Group System; D000208:Acute Disease; D000328:Adult; D000368:Aged; D000818:Animals; D000906:Antibodies / Q000302:isolation & purification*; D002908:Chronic Disease; D003168:Complement Fixation Tests; D003593:Cytoplasm / Q000276:immunology; D005455:Fluorescent Antibody Technique; D006168:Guinea Pigs; D006432:Hemochromatosis / Q000276:immunology; D006801:Humans; D007070:Immunoglobulin A / Q000302:isolation & purification; D007074:Immunoglobulin G / Q000302:isolation & purification; D007075:Immunoglobulin M / Q000302:isolation & purification; D007223:Infant; D008861:Microsomes / Q000276:immunology; D008875:Middle Aged; D010182:Pancreatic Diseases / Q000276:immunology*; D010184:Pancreatic Extracts / Q000276:immunology; D010190:Pancreatic Neoplasms / Q000276:immunology; D010195:Pancreatitis / Q000276:immunology; D051381:Rats; D012463:Saliva / Q000276:immunology
D000017:ABO Blood-Group System; D000906:Antibodies; D007070:Immunoglobulin A; D007074:Immunoglobulin G; D007075:Immunoglobulin M; D010184:Pancreatic Extracts