Interaction of concanavalin A with the surface of virus-infected cells.
Infection of untransformed cells with a wide-range of non-oncogenic enveloped viruses causes a significant increase in their susceptibility to agglutination by concanavalin A (Con A). The increased Con A agglutinability of these cells is not caused by an increase in the number of Con A sites on the cell surface but involves alteration in the surface properties of infected cells to allow redistribution of Con A receptors to form "patches" following binding of Con A to the cell surface. Similarities between Con A-mediated agglutination of normal cells infected with non-oncogenic viruses and the agglutination response to cells transformed by oncogenic viruses will be reviewed. Finally, the use of Con A as an experimental tool to modify the replication and cytopathogenicity of non-oncogenic viruses grown in mammalian cells will be presented.
D000371:Agglutination / Q000187:drug effects; D000818:Animals; D001665:Binding Sites / Q000187:drug effects; D002417:Cattle; D002449:Cell Aggregation / Q000187:drug effects; D002459:Cell Fusion / Q000187:drug effects; D002471:Cell Transformation, Neoplastic; D002477:Cells; D002642:Chick Embryo; D003208:Concanavalin A / Q000494:pharmacology*; D006224:Cricetinae; D003588:Cytopathogenic Effect, Viral / Q000187:drug effects; D004798:Enzymes / Q000494:pharmacology; D009522:Newcastle disease virus; D014779:Virus Replication / Q000187:drug effects; D014780:Viruses / Q000187:drug effects
D004798:Enzymes; D003208:Concanavalin A