Action of ethanol and other solvents on the nerve tissue under in vitro conditions.
Explants and cells of nervous tissue were cultivated in the presence of aethanol, tween 80, dimethylformamid (DMF) and dimethylsulfoxid (DMSO) and the influence upon the index of area, the growth rate and fiber index was observed. They are important to solutions of drugs for tests in vitro. At the beginning of the cultivation aethanol in vitro influenced the regeneration of nerve fibers from explants and cells. A significant increase of the index of growth was observed. After a long term influence of tween 80, DMF and DMSO an inhibition of differentiation of neurons in vitro was observed.
D000818:Animals; D002452:Cell Count / Q000187:drug effects; D002454:Cell Differentiation / Q000187:drug effects; D002455:Cell Division / Q000187:drug effects; D002642:Chick Embryo; D003470:Culture Media; D046508:Culture Techniques; D004121:Dimethyl Sulfoxide / Q000494:pharmacology*; D004126:Dimethylformamide / Q000494:pharmacology*; D000431:Ethanol / Q000494:pharmacology*; D006352:Heart Ventricles; D006624:Hippocampus / Q000196:embryology; D009474:Neurons / Q000166:cytology / Q000187:drug effects*; D011092:Polyethylene Glycols / Q000494:pharmacology*; D011136:Polysorbates / Q000494:pharmacology*; D051381:Rats; D013687:Telencephalon; D012668:Trigeminal Ganglion
D003470:Culture Media; D011136:Polysorbates; D000431:Ethanol; D011092:Polyethylene Glycols; D004126:Dimethylformamide; D004121:Dimethyl Sulfoxide
Uber die Wirkung von Athanol und anderen Lösungsmitteln auf das Nervengewebe unter In-vitro-Bedingungen.