title: Lymphokines in the rheumatoid joint.
abstract: Joint fluids and culture supernatants of synovial tissue were examined for the presence of two lymphokines. Migration inhibitory activity was found in 16 of 22 rheumatoid fluids (73%), in 3 of 15 osteoarthritis fluids (20%), and in 3 of 11 fluids from patients with various inflammatory arthritides (27%). Blastogenic activity was present in 14 of 15 rheumatoid fluids and in 1 of 7 nonrheumatoid effusions. The active materials eluted with the third peak from Sephadex G-200 and were therefore smaller than immunoglobulin or immune complexes. These findings suggest that lymphokine-like substances were present in effusions and synovial tissue of most patients with rheumatoid arthritis and some patients with other forms of chronic synovitis.
mesh_terms: D016918:Arthritis, Reactive / Q000276:immunology; D001172:Arthritis, Rheumatoid / Q000276:immunology*; D002845:Chromatography; D006073:Gout / Q000276:immunology; D006801:Humans; D066298:In Vitro Techniques; D007592:Joint Diseases / Q000276:immunology; D008213:Lymphocyte Activation; D008222:Lymphokines / Q000302:isolation & purification*; D008263:Macrophage Migration-Inhibitory Factors / Q000302:isolation & purification; D008264:Macrophages / Q000276:immunology; D010003:Osteoarthritis / Q000276:immunology; D013582:Synovial Fluid / Q000276:immunology*; D013583:Synovial Membrane / Q000276:immunology*
chemical_list: D008222:Lymphokines; D008263:Macrophage Migration-Inhibitory Factors