Pharmacological and toxicological studies with 1-benzyl-3-(2,3-dihydroxypropoxy)indazole.
1-Benzyl-3-(2,3-dihydroxypropoxy)-indazole (benzidol) is a novel indazolane derivative with marked antiinflammatory, analgesic and antipyretic properties. Its acute toxicity is three times less than that of benzidamine and five times less than that of phenylbutazone. Rats, mice, guinea pigs and rabbits treated with benzidol during 6 months at doses of 5, 50 and 200 mg/kg did not present any pathological alteration. The anti-inflammatory activity of benzidol is similar to that of phenylbutazone and higher than that of benzidamine. The analgesic and antipyretic properties are also considerable. Benzidol is better tolerated than the mentioned drugs with similar activities.
D000014:Abnormalities, Drug-Induced; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal; D005260:Female; D006168:Guinea Pigs; D007191:Indazoles / Q000494:pharmacology* / Q000633:toxicity; D007928:Lethal Dose 50; D008297:Male; D051379:Mice; D009154:Mutation / Q000187:drug effects; D010437:Peptic Ulcer / Q000139:chemically induced; D010653:Phenylbutazone / Q000494:pharmacology; D011720:Pyrazoles / Q000494:pharmacology*; D011817:Rabbits; D051381:Rats
D000894:Anti-Inflammatory Agents, Non-Steroidal; D007191:Indazoles; D011720:Pyrazoles; C013838:benzidol; D010653:Phenylbutazone