Relationship among skin tests, bronchial challenge and serology in house dust and Candida albicans allergic asthma.
One hundred and ninety-six asthmatic patients were examined by inhalation challenge using house dust and candida albicans; an early, dual or late bronchial response was induced where IgE, C3 and C4 were elevated. In some of late responses by candida inhalation there was a decrease or almost no increase in IgE and a fall in C3 and C4. There was a considerable correlation between skin tests and bronchial responses. An induced bronchial response, early, dual or late, was identified as Type I, While candida-induced late bronchial responses were Type I and Type III. There is some question whether Type I plus Type III mechanism may be involved in the dual bronchial response provoked with candida.
D000293:Adolescent; D001249:Asthma / Q000276:immunology*; D001980:Bronchi / Q000276:immunology*; D002176:Candida albicans / Q000276:immunology*; D002648:Child; D002675:Child, Preschool; D003176:Complement C3; D003181:Complement C4; D004391:Dust; D005260:Female; D006801:Humans; D007073:Immunoglobulin E; D008297:Male; D012882:Skin Tests
D003176:Complement C3; D003181:Complement C4; D004391:Dust; D007073:Immunoglobulin E