A study of the oncogenicity of adenovirus type 2 transformed rat embryo cells.
Rat embryo cells were transformed by adenovirus type 2 at different multiplicities of infection. The oncogenic potential of the resulting transformed lines varied considerably but a relationship was found to exist between transforming virus dose and oncogenicity of the resulting transformed lines. Possible reasons for the considerable variation in oncogenicity of the transformed lines are discussed, giving particular consideration to cellular antigenicity and recent molecular biology studies of adenovirus type 2 transformed cell lines.
D000256:Adenoviridae; D000367:Age Factors; D000818:Animals; D000961:Antilymphocyte Serum; D002460:Cell Line; D002471:Cell Transformation, Neoplastic; D002999:Clone Cells; D007165:Immunosuppression Therapy; D009368:Neoplasm Transplantation; D051381:Rats; D012513:Sarcoma, Experimental / Q000473:pathology; D013601:T-Lymphocytes / Q000276:immunology; D014184:Transplantation, Homologous
D000961:Antilymphocyte Serum