Immunological membrane markers of Hodgkin's cells.
Reed-Sternberg and other Hodgkin's giant cells derived from involved spleens and lymph nodes of patients with Hodgkin's disease were examined for surface markers of T and B cells and macrophages. Attachment and phagocytosis of untreated (E) or sensitized (EA and EAC) sheep red blood cells and yeast by Reed-Sternberg cells did not occur. IgG frequently detected at the membrane of Reed-Sternberg cells was partially removed by incubation and washing at 37 degrees C. Fluorescence with a specific anti-T cell serum was not seen on Reed-Sternberg and other Hodgkin's giant cells lack most detectable normal human lymphoid cell markers, but do exhibit membrane bound immunoglobulin possibly of exogenous origin.
D001402:B-Lymphocytes / Q000473:pathology*; D001665:Binding Sites; D002462:Cell Membrane / Q000276:immunology; D003165:Complement System Proteins; D006644:Histiocytes / Q000473:pathology*; D006689:Hodgkin Disease / Q000473:pathology*; D006801:Humans; D007141:Immunoglobulin Fc Fragments; D007074:Immunoglobulin G / Q000032:analysis; D010587:Phagocytosis; D011947:Receptors, Antigen, B-Cell / Q000032:analysis
D007141:Immunoglobulin Fc Fragments; D007074:Immunoglobulin G; D011947:Receptors, Antigen, B-Cell; D003165:Complement System Proteins