The use of protease inhibitor (trasylol) and heparin in cardiorespiratory resuscitation. I. Studies of the blood clotting system.
The purpose of the study was the assessment of the effect of protease inhibitor (trasylol) and heparin on the blood clotting system during cardiorespiratory resuscitation. The studies were carried out in two experimental groups of rabbits. In group I oxygen was given, cardiac massage was applied, alkalinizing agents and drugs improving the action of the heart and the peripheral circulation were administered. In group II trasylol and heparin were given additionally. The studies proved that cardiorespiratory arrest causes development of the intravascular clotting syndrome. Resuscitation management in group I failed to correct the disturbances in the blood clotting system. On the other hand, in group II they were partly corrected. The animals in this group survived the experiment. The administration of protease inhibitor and heparin increased the efficiency of resuscitation management.
D000818:Animals; D007611:Aprotinin / Q000494:pharmacology*; D001777:Blood Coagulation / Q000187:drug effects*; D004211:Disseminated Intravascular Coagulation / Q000209:etiology; D005260:Female; D006323:Heart Arrest / Q000150:complications; D006493:Heparin / Q000494:pharmacology*; D011817:Rabbits; D012151:Resuscitation; D013916:Thrombelastography
D006493:Heparin; D007611:Aprotinin