Stimulation of granulopoiesis by androgens without concomitant increase in the serum level of colony stimulating factor.
The marked enhancing effect of daily injections of 19-nortestosterone decanoate (19-ND) upon granulopoietic recovery of mice made neutropenic by a single dose of BCNU was studeid in regard to the possible regulatory role of CSF. Serum levels of CSF in BCNU-treated mice with or without 19-ND injection were not found to differ significantly from those in normal mice. BCNU treatment with or without 19-ND did not alter the CSF increases in response to endotoxin injection. Increases in dividing marrow granulocytes in the 19-ND mice were preceded by increases in their marrow CFC. The acceleration of granulopoietic regeneration was thus not mediated by the serum colony stimulating factor. It is attributed to a stimulatory effect of 19-ND on proliferation of CFC and/or CFU.
D000380:Agranulocytosis / Q000097:blood*; D000818:Animals; D001853:Bone Marrow / Q000187:drug effects; D001854:Bone Marrow Cells; D002330:Carmustine / Q000009:adverse effects / Q000494:pharmacology; D002455:Cell Division / Q000187:drug effects; D003115:Colony-Stimulating Factors / Q000097:blood*; D004731:Endotoxins / Q000494:pharmacology; D005260:Female; D006023:Glycoproteins / Q000097:blood*; D006098:Granulocytes / Q000187:drug effects*; D007962:Leukocytes / Q000187:drug effects*; D008070:Lipopolysaccharides / Q000494:pharmacology; D051379:Mice; D009277:Nandrolone / Q000494:pharmacology*; D009503:Neutropenia / Q000097:blood* / Q000139:chemically induced; D012485:Salmonella typhi; D013268:Stimulation, Chemical; D013997:Time Factors
D003115:Colony-Stimulating Factors; D004731:Endotoxins; D006023:Glycoproteins; D008070:Lipopolysaccharides; D009277:Nandrolone; D002330:Carmustine