Characterization of a subpopulation of human T lymphocytes reactive with an heteroantiserum to human brain.
A rabbit antiserum to human fetal brain reacted after suitable absorptions with a subpopulation of human normal T cells. The distribution of reactive T cells varied according to the organ tested: 23% of peripheral blood lymphocytes, 5% of tonsil lymphocytes, and less than 1% of thymocytes were positive. Reactive cells did not transform after phytohemagglutinin or pokeweed stimulation but were at least weakly stimulated by allogeneic cells. T-derived neoplastic cells from one case of T acute lymphoblastic leukemia, two patients with Sezary syndrome, and from three out of five cases of T chronic lymphocytic leukemias (CLL) yielded negative results. In contrast, all the leukemic cells from two other patients with T-derived CLL were positive suggesting a proliferation of homogeneous cells arising from only a subpopulation of T lymphocytes.
D000042:Absorption; D000818:Animals; D000918:Antibody Specificity; D002469:Cell Separation; D006801:Humans; D007106:Immune Sera / Q000302:isolation & purification*; D007945:Leukemia, Lymphoid / Q000276:immunology; D008213:Lymphocyte Activation; D011817:Rabbits; D013601:T-Lymphocytes / Q000276:immunology*
D007106:Immune Sera