Effects of lymphocytotoxins of systemic lupus erythematosus (SLE) sera on T and B lymphocytes.
SLE lymphocytotoxins can be demonstrated on the lymphocytes by immunofluorescence. Complement addition lyses the cells covered with LCT. The proportion of B and T cells as determined by surface immunoglobulins and spontaneous rosette formation of lymphocytes from healthy donors remains unchanged after LCT and complement treatment. The proportion of B and T cells of SLE lymphocytes was altered after cell lysis. The B cells seemed to be relatively resistant, and the T cells more susceptible, to autologous LCT. Thus the relative decrease in the number of T cells in active SLE may be the consequence of surface bound LCT with its effect on the circulating T cells.
D001402:B-Lymphocytes / Q000276:immunology*; D003165:Complement System Proteins; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000276:immunology*; D008233:Lymphotoxin-alpha; D013601:T-Lymphocytes / Q000276:immunology*
D008233:Lymphotoxin-alpha; D003165:Complement System Proteins