Enzymic studies on the metabolism of 5-hydroxyindoles in the brain.
It was shown that rat brain extract catalysed the formation of 5HIAA from 5HTP via a transamination pathway which does not contain 5HT but 5-hydroxyindolepyruvic acid as an intermediate.
D006916:5-Hydroxytryptophan / Q000378:metabolism*; D000818:Animals; D001921:Brain / Q000378:metabolism*; D006897:Hydroxyindoleacetic Acid / Q000378:metabolism*; D007656:Ketoglutaric Acids / Q000494:pharmacology; D007700:Kinetics; D051381:Rats
D007656:Ketoglutaric Acids; D006897:Hydroxyindoleacetic Acid; D006916:5-Hydroxytryptophan