Effects of Newcastle disease virus (NDV) on infection of adult mice with the Thogoto-like Ar-126 arbovirus.
Inoculation of mice with Newcastle disease virus (NDV) alters the course of infection with the Thogoto-like arbovirus Tho-Ar-126. The Tho-Ar-126 content of liver, spleen, and lymph nodes was approximately 10 times greater in mice treated with NDV 24 h before infection; the mortality was somewhat increased, but liver damage (as indicated by serum transaminase levels) did not seem to be potentiated. Lymphocytopenia was observed in NDV-inoculated mice, and in the spleen and lymph nodes the proportion of lymphocytes susceptible to lysis by anti-theta (a marker for thymus-derived lymphocytes) was markedly decreased in these animals. This suggests that NDV potentiates infection by Tho-Ar-126 through its action on thymus-derived lymphocytes.
D000410:Alanine Transaminase / Q000097:blood; D000818:Animals; D001102:Arbovirus Infections / Q000276:immunology / Q000382:microbiology* / Q000401:mortality; D001103:Arboviruses / Q000254:growth & development*; D001219:Aspartate Aminotransferases / Q000097:blood; D007111:Immunity, Cellular; D008099:Liver / Q000382:microbiology; D008198:Lymph Nodes / Q000382:microbiology; D008297:Male; D051379:Mice; D008808:Mice, Inbred CBA; D009522:Newcastle disease virus / Q000254:growth & development*; D013154:Spleen / Q000382:microbiology; D013601:T-Lymphocytes / Q000276:immunology
D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase