Potentiation of the L-5-hydroxytryptophan-induced elevation of plasma corticosterone levels in rats by a specific inhibitor of serotonin uptake.
The ability of L-5-hydroxytryptophan (L-5HTP), a serotonin precursor, to elevate plasma levels of corticosterone in rats was confirmed. Pretreatment of the rats with 3-(p-trifluoromethylphenoxy)-N-methyl-3-phenyl-propylamine hydrochloride (Lilly 110140) markedly enhanced the elevation of corticosterone levels  by L-5HTP. Since Lilly 110140 is a specific inhibitor of serotonin uptake, these results support the hypothesis that L-5HTP elevates corticosterone by enhancing neurotransmission through a serotoninergic pathway influencing ACTH release.
D006916:5-Hydroxytryptophan / Q000494:pharmacology*; D000818:Animals; D003345:Corticosterone / Q000097:blood*; D004305:Dose-Response Relationship, Drug; D004357:Drug Synergism; D006845:Hydrocarbons, Fluorinated / Q000494:pharmacology; D008297:Male; D010647:Phenyl Ethers / Q000494:pharmacology; D011437:Propylamines / Q000494:pharmacology*; D051381:Rats; D012701:Serotonin / Q000378:metabolism; D012702:Serotonin Antagonists; D013050:Spectrometry, Fluorescence
D006845:Hydrocarbons, Fluorinated; D010647:Phenyl Ethers; D011437:Propylamines; D012702:Serotonin Antagonists; D012701:Serotonin; D006916:5-Hydroxytryptophan; D003345:Corticosterone