[Effect of trypsin-like enzyme inhibitor on certain metabolic processes in the acute period of experimental myocardial ischemia].
The effect of trasylol upon the activeness of proteolysis in the cytoplasm and mitochondrial-lysosomal fractions of the heart muscle was studied in the acute experimental period of myocardial ischaemia (5 days) along with a determination of the spectrum of the iso-enzymes of the lactate- and malate- dehydrogenases. For the evaluation of oxidation processes in vitro the iections. Trasylol was found to limit the proteolysis in the cytostructures of the myocardium cell, to increase the activity of the transaminases, as well as to help the normalization of thespectrum of the NAD-dependent iso-enzymes. At the same time, under the effect of the employed drug, the myocardial consumption of the radioactive carbon from the acetate Na-2C-14 increases.
D000818:Animals; D007611:Aprotinin / Q000494:pharmacology*; D003327:Coronary Disease / Q000201:enzymology / Q000378:metabolism* / Q000473:pathology; D006321:Heart / Q000187:drug effects; D007527:Isoenzymes / Q000378:metabolism; D007770:L-Lactate Dehydrogenase / Q000378:metabolism; D008291:Malate Dehydrogenase / Q000378:metabolism; D008931:Mitochondria, Muscle / Q000378:metabolism; D009206:Myocardium / Q000378:metabolism; D011817:Rabbits
D007527:Isoenzymes; D007611:Aprotinin; D007770:L-Lactate Dehydrogenase; D008291:Malate Dehydrogenase
Vliianie ingibitora tripsinopodobnykh fermentov na nekotorye metabolicheskie protsessy v ostrom periode eksperimental'noĭ ishemii miokarda