title: Antibody-producing cells: virus-induced alteration of response to antigen.
abstract: Spleen antibody-forming cells of mice yield a 3- to 10-fold increase in their response to sheep erythrocyte antigen if they are acutely infected by lactate dehydrogenase-elevating virus. This early stimulation is replaced by a long-term inhibition of the antibody-forming cells as the viremia goes into its persisting chronic stage. These contrasting immunological phenomena are examined as contributing factors responsible for the enhancement by this virus of asparaginase (EC 3.5.1.1; L-asparagine amidolydrolase) therapy against leukemia in mice, and for the alteration of the susceptibility of mice to various neoplastic processes.
mesh_terms: D000208:Acute Disease; D000818:Animals; D000917:Antibody Formation; D000918:Antibody Specificity; D000921:Antibody-Producing Cells / Q000276:immunology*; D001215:Asparaginase / Q000276:immunology / Q000627:therapeutic use; D001402:B-Lymphocytes / Q000276:immunology; D002908:Chronic Disease; D005260:Female; D007772:Lactate dehydrogenase-elevating virus; D007942:Leukemia, Experimental / Q000188:drug therapy; D051379:Mice; D009929:Organ Size; D012328:RNA Viruses; D013154:Spleen / Q000033:anatomy & histology / Q000276:immunology
chemical_list: D001215:Asparaginase