Changes in human  lymphocyte subpopulation in Hodgkin's lymphoma.
An investigation of 33 patients with Hodgkin's lymphoma--both treated and untreated--has revealed lymphocytopenia and a significant decline in the absolute number of T lymphocytes labeled with rosettes with sheep erythrocytes to be due in these patients not to the tumorous disease itself, but probably to the intensive nature of the therapy. A marked decline in the absolute number of B lymphocyte subpopulation, determined by the formation of rosettes with mouse erythrocytes, occurs during a fresh relapse of patients with an active Hodgkin's lymphoma. This decline is probably independent of the preceding treatment, of the clinical stage of the disease and of its histological type.
D000328:Adult; D001402:B-Lymphocytes / Q000276:immunology / Q000473:pathology*; D004912:Erythrocytes / Q000276:immunology; D005260:Female; D006689:Hodgkin Disease / Q000276:immunology / Q000473:pathology* / Q000628:therapy; D006801:Humans; D007958:Leukocyte Count; D008297:Male; D013601:T-Lymphocytes / Q000276:immunology / Q000473:pathology*