Carcinomatous polyarthritis. The presenting symptom of an ovarian tumor and association with a platelet activating factor.
A 59-year-old white female presented with an acute polyarthritis, fever, and mental confusion. Accompanying blood changes included positive tests for rheumatoid factor and antinuclear factor, anemia, leukocytosis, thrombocytosis, and a circulating factor that stimulated serotonin release from normal platelets. Exploratory laporatomy for a mobile pelvic mass revealed an adenocarcinoma of the left ovary which was completely resected. Shortly thereafter the patient's acute symptoms subsided. After 2 years of follow-up the patient has remained free of symptoms and the serologic changes have reverted to normal.
D000230:Adenocarcinoma / Q000150:complications* / Q000473:pathology; D000974:Antibodies, Antinuclear / Q000032:analysis; D001168:Arthritis / Q000097:blood / Q000209:etiology* / Q000276:immunology; D001792:Blood Platelets / Q000378:metabolism; D005260:Female; D006801:Humans; D008875:Middle Aged; D010051:Ovarian Neoplasms / Q000150:complications* / Q000473:pathology; D012217:Rheumatoid Factor / Q000032:analysis; D012701:Serotonin / Q000378:metabolism
D000974:Antibodies, Antinuclear; D012701:Serotonin; D012217:Rheumatoid Factor