title: Sinus histiocytosis with massive lymphadenopathy.
abstract: Five cases of "sinus histiocytosis with massive lymphadenopathy" are reported. The clinical features and histopathological appearances are described. The majority were African children with massive cervical lymphadenopathy. Histologically, the lymphnode sinuses are widely dilated by mature histiocytes, with phagocytosis of lymphocytes and other hematopoietic cells by the proliferating histiocytes. The diagnostic difficulties are discussed. These are the first cases recognized in Zambia.
mesh_terms: D000293:Adolescent; D000328:Adult; D002675:Child, Preschool; D003937:Diagnosis, Differential; D005260:Female; D006644:Histiocytes / Q000473:pathology*; D006646:Histiocytosis, Langerhans-Cell / Q000175:diagnosis; D006689:Hodgkin Disease / Q000175:diagnosis; D006801:Humans; D008198:Lymph Nodes / Q000473:pathology; D008206:Lymphatic Diseases / Q000175:diagnosis / Q000473:pathology*; D008297:Male; D014388:Tuberculosis, Lymph Node / Q000175:diagnosis