Post-transplant function of cadaver kidneys preserved with plasma perfusate containing antidonor antibody.
Two cadaver kidneys were preserved by the perfusion method with AB cryoprecipitated plasma which contained antidonor lymphocytotoxic antibody. The kidneys were transplanted subsequently and no demonstrable immunologic damage to the kidneys was observed in the preservation and post-transplantation periods. In one patient renal function was immediate, and function has remained satisfactory in the 3 month follow-up period. The other patient had an initial period (2 weeks) of acute tubular necrosis, but renal function became satisfactory and the patient's condition has remained stable in the 3 month follow-up period. The significance of antidonor lymphocytotoxic antibody in the plasma perfusate on subsequent kidney function has been discussed.
D000906:Antibodies; D000961:Antilymphocyte Serum; D002102:Cadaver; D006649:Histocompatibility Antigens; D006801:Humans; D016030:Kidney Transplantation; D008297:Male; D008875:Middle Aged; D009926:Organ Preservation / Q000379:methods*; D010477:Perfusion; D014019:Tissue Donors; D014021:Tissue Preservation / Q000379:methods*; D014184:Transplantation, Homologous
D000906:Antibodies; D000961:Antilymphocyte Serum; D006649:Histocompatibility Antigens