title: [Dimer-X in the intracranial subarachnoid space--its toxicity (author's transl)].
abstract: The reaction of the rats to injection of Dimer-X into the intracranial subarachnoid space or the cerebrum was examined. When 28% iodine Dimer-X was injected into the subarachnoid space, 7 of 10 rats showed agitation, which is the most severe complication, and all died within one hour. All of the reactions were reduced with the lower concentrations of Dimer-X. The rats which were premedicated with Valium and/or Decadron revealed fewer and less severe complications. It is believed that the intracerebral injection method has many disadvantages, the results of its experiment are therefore reported without further elaboration. From the results of the experiment it is concluded as follows: 1) Dimer-X should not be injected into the intracranial subarachnoid space. 2) Dimer-X of low concentration in the subarachnoid space reduces the complications. 3) Complications from the subarachnoid application of Dimer-X can be reduced by premedication with Valium and Decadron.
mesh_terms: D000818:Animals; D001519:Behavior / Q000187:drug effects; D014695:Cerebral Ventriculography / Q000009:adverse effects; D005260:Female; D007482:Iothalamate Meglumine / Q000008:administration & dosage / Q000633:toxicity*; D007483:Iothalamic Acid / Q000031:analogs & derivatives*; D008297:Male; D051381:Rats; D012640:Seizures / Q000139:chemically induced; D013346:Subarachnoid Space; D014202:Tremor / Q000139:chemically induced
chemical_list: D007483:Iothalamic Acid; D007482:Iothalamate Meglumine