[Myocardial contractility in dogs in hemorrhagic shock and after volumn replacement (author's transl)].
Myocardial contractility was evaluated in 8 out of 14 anaesthetized mongrel dogs during haemorrhagic shock and after volume replacement with Dextran 60 using the force-velocity relation of the contractile elements at zero load (Vmax). 7 animals received 50,000 or 20,000 KIE respectively of a proteinase inhibitor after bleeding and immediately before and one hour after the infusion of Dextran 60. The release of the lysosomal enzymes acid phosphatase and beta-glucuronidase was inhibited significantly (p less than 0.05) in the animals treated with Trasylol. However, the inhibition of the lysosomal enzymes seems not to have a decisive influence on the dynamic of the macro- and microcirculation and the myocardial contractility.
D000135:Acid Phosphatase / Q000378:metabolism; D000818:Animals; D007611:Aprotinin / Q000494:pharmacology; D001794:Blood Pressure; D002245:Carbon Dioxide / Q000097:blood; D003911:Dextrans / Q000627:therapeutic use; D004195:Disease Models, Animal; D004285:Dogs; D004791:Enzyme Inhibitors; D005260:Female; D005966:Glucuronidase / Q000378:metabolism; D006352:Heart Ventricles; D006400:Hematocrit; D008297:Male; D008833:Microcirculation; D009132:Muscles / Q000098:blood supply; D009200:Myocardial Contraction; D010100:Oxygen / Q000097:blood; D010313:Partial Pressure; D010952:Plasma Substitutes / Q000008:administration & dosage*; D012771:Shock, Hemorrhagic / Q000188:drug therapy / Q000201:enzymology / Q000503:physiopathology*
D003911:Dextrans; D004791:Enzyme Inhibitors; D010952:Plasma Substitutes; D002245:Carbon Dioxide; D007611:Aprotinin; D000135:Acid Phosphatase; D005966:Glucuronidase; D010100:Oxygen
Die Kontraktilität des linken Ventrikels des Hundes im hämorrhagischen Schock und nach Volumenersatz