title: [Fetal haemoglobin levels in acquired and congenital haematological diseases and malignant tumours in adults (author's transl)].
abstract: Hb F values were estimated in 336 adults on 525 occasions. A variable elevation appeared not only in patients with a variety of haematological diseases, but also in conjunction with malignant neoplasms, liver disease etc. The highest values were encountered in cases of pernicious anaemia, haemolytic anaemia, panmyelopathy and plasmocytoma. The determination of Hb F in peripheral blood smears by means of this extremely simple elution method (Betke and Kleihauer) represents a useful tool in the diagnosis of haematological disorders in adults, especially the haemoglobinopathies. The possible causes of this biochemical redifferentiation of erythropoiesis are discussed.
mesh_terms: D000328:Adult; D004920:Erythropoiesis; D005260:Female; D005319:Fetal Hemoglobin / Q000378:metabolism*; D006402:Hematologic Diseases / Q000097:blood*; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007674:Kidney Diseases / Q000097:blood; D008107:Liver Diseases / Q000097:blood; D008297:Male; D009369:Neoplasms / Q000097:blood*; D012216:Rheumatic Diseases / Q000097:blood
chemical_list: D005319:Fetal Hemoglobin
vernacular_title: Das fetale Hämoglobin bei hämatologischen Erkrankungen und malignen Neoplasien des Erwachsenen