title: [Insulin precursors--a historical synopsis. First diabetes treatment trials using pancreas extracts].
abstract: The highly interesting and successful attempts to treat diabetes with pancreas extracts deserve a historical review. Some of these experiments were performed long before the isolation and use of insulin by the Canadians Banting, Best, Macleod and Collip in 1921--22. Successful isolation of insulin, known as acomatol and pancreatin, was first carried out before the Canadian research-workers published their results. Particular credit goes above all to Paulesco, Reuter and Zuelzer.
mesh_terms: D002170:Canada; D003920:Diabetes Mellitus / Q000188:drug therapy* / Q000266:history; D005858:Germany; D049672:History, 19th Century; D049673:History, 20th Century; D007328:Insulin / Q000266:history*; D010184:Pancreatic Extracts / Q000627:therapeutic use*; D012383:Romania
chemical_list: D007328:Insulin; D010184:Pancreatic Extracts
vernacular_title: Insulin-Vorläufer -- ein historischer Abriss. Erste Diabetes-Behandlungsversuche mit Pankreasextrakten