The effect of methylphenidate on cardiovascular sensory differentiation on the hyperkinetic syndrome.
In the present study, the action of methylphenidate on mean heart rate was studied while hyperkinetic children were attending to monosensory, bisensory and trisensory stimuli presentations. Neither children receiving methylphenidate nor those receiving placebo exhibited a significant shift in tonic heart rate during relaxation periods. While attending to sensory stimuli, heart rates were higher for children receiving placebo than for those receiving methylphenidate in all experimental conditions for the high and moderate degrees of hyperkinetic behavior. A drug reversal effect was demonstrated in mildly hyperkinetic children.
D000161:Acoustic Stimulation; D001143:Arousal / Q000187:drug effects; D002648:Child; D002986:Clinical Trials as Topic; D005260:Female; D006339:Heart Rate / Q000187:drug effects*; D006801:Humans; D006948:Hyperkinesis / Q000188:drug therapy / Q000503:physiopathology*; D008297:Male; D008774:Methylphenidate / Q000494:pharmacology* / Q000627:therapeutic use; D010775:Photic Stimulation; D010919:Placebos; D014110:Touch
D010919:Placebos; D008774:Methylphenidate