Regulation of antibody formation in chickens escaping from tolerance to human serum albumin.
The immune capacity of chickens made tolerant to human serum albumin just after hatching was studied after a primary and secondary challenge at 7--14 weeks of age, of either 1 mg/kg or 100 mg/kg. The class and avidity of antibody produced by birds "escaping" from tolerance was similar to normal controls. The escaping chickens made a normal peak antibody response to a high dose but not to a low dose (except that the response to a low secondary dose after priming with a high dose was normal); but the decline of the antibody titer was abrupt, indicating inability to maintain the response. It is concluded that the antibody-forming capacity of B cells is normal, but regulation of antibody formation is impaired in previously tolerant chickens.
D000818:Animals; D000831:Animals, Newborn; D000917:Antibody Formation; D000936:Antigen-Antibody Complex; D000937:Antigen-Antibody Reactions; D001402:B-Lymphocytes / Q000276:immunology; D002645:Chickens / Q000276:immunology; D005260:Female; D007108:Immune Tolerance; D007114:Immunization; D007117:Immunization, Secondary; D007074:Immunoglobulin G / Q000032:analysis; D007158:Immunologic Techniques; D008297:Male; D012709:Serum Albumin
D000936:Antigen-Antibody Complex; D007074:Immunoglobulin G; D012709:Serum Albumin