title: Structure-activity relationship of some steroidal compounds in ocular inflammation.
abstract: The structure-activity relationship of some topically applied 21-desoxy-substituted steroids as anti-inflammatory agents was investigated; the anti-inflammatory activity remained unaltered or increased on introducing a methyl group in position 6alpha and a hydroxyl group in position 11beta, even after eliminating the hydroxyl group in position 21. The activity of the molecule was further increased by the introduction of a hydroxyl group in position 17alpha and a fluorine atom in position 9alpha.
mesh_terms: D000818:Animals; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use*; D004353:Drug Evaluation, Preclinical; D009877:Endophthalmitis / Q000188:drug therapy*; D005260:Female; D006854:Hydrocortisone / Q000627:therapeutic use; D006908:Hydroxyprogesterones / Q000627:therapeutic use; D011239:Prednisolone / Q000627:therapeutic use; D011278:Pregnanes / Q000627:therapeutic use*; D011282:Pregnenediones / Q000627:therapeutic use; D051381:Rats; D013329:Structure-Activity Relationship
chemical_list: D000893:Anti-Inflammatory Agents; D006908:Hydroxyprogesterones; D011278:Pregnanes; D011282:Pregnenediones; D011239:Prednisolone; D006854:Hydrocortisone