Binding of C-reactive protein to antigen-induced but not mitogen-induced T lymphoblasts.
The C-reactive protein (CRP), an acute phase reactant which binds selectively to T (thymus-derived) lymphocytes, was found to bind to lymphoblasts formed upon stimulation with antigens but not with mitogens. Binding of CRP thus serves as a marker for antigen-reactive (-reacted) as opposed to mitogen-reative (-reacted) T cells, suggesting that these represent separate subpopulations, and supports the developing concept that CRP play an important role in the regulation of responses critical to  inflammation, host defense, and tissue repair.
D000941:Antigens; D002097:C-Reactive Protein / Q000378:metabolism*; D002454:Cell Differentiation; D006649:Histocompatibility Antigens; D006801:Humans; D008214:Lymphocytes / Q000378:metabolism; D008934:Mitogens; D011485:Protein Binding; D013601:T-Lymphocytes / Q000166:cytology / Q000276:immunology* / Q000378:metabolism; D014373:Tuberculin
D000941:Antigens; D006649:Histocompatibility Antigens; D008934:Mitogens; D014373:Tuberculin; D002097:C-Reactive Protein