Prophylaxis with dextran 70 against thrombosis in patients with fractures of the upper end of the femur.
A trial was undertaken to assess the effect of dextran 70 (Macrodex) in prophylaxis against thrombosis in womem over 65 years with fractures of the upper end of the femur. The dosage used was 500 ml at operation and 500 ml on the first postoperative day. At this dosage given at this time there was no difference in the overall incidence of clinically diagnosed deep venous thrombosis in the group of patients given dextran 70 compared with the control group. There was a tendency for thrombosis to occur earlier in the control group. The mortality rates at 3 weeks and even at 6 months were less in the treated group than in the control series.
D002986:Clinical Trials as Topic; D003911:Dextrans / Q000008:administration & dosage / Q000627:therapeutic use*; D005264:Femoral Fractures; D005500:Follow-Up Studies; D006801:Humans; D013924:Thrombophlebitis / Q000401:mortality / Q000517:prevention & control*; D013997:Time Factors
D003911:Dextrans