[Dopamine effects on the pulmonary circulation of innervated and autotransplanted lungs (author's transl)].
The effects of dopamine on the pulmonary vascular resistance were investigated in 7 normal and 9 autotransplanted canine lungs during perfusion in situ. Dopamine (up to 13,5 gamma/kg BW, rapid injection) acts as a vasoconstrictor by alpha-receptor stimulation. Vasodilative effects could not be registered neither by very small amounts of dopamine nor during alpha-blockade with phentolamine. No difference could be detected between the vascular reactions of normal and autotransplanted lungs.
D000818:Animals; D001011:Aorta / Q000502:physiology; D016275:Atrial Function; D001794:Blood Pressure / Q000187:drug effects; D004285:Dogs; D004298:Dopamine / Q000008:administration & dosage / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D004347:Drug Interactions; D006339:Heart Rate / Q000187:drug effects; D007269:Injections, Intra-Arterial; D008168:Lung / Q000294:innervation; D016040:Lung Transplantation; D010477:Perfusion; D010646:Phentolamine / Q000494:pharmacology; D011651:Pulmonary Artery; D011652:Pulmonary Circulation / Q000187:drug effects*; D011955:Receptors, Drug / Q000187:drug effects; D014182:Transplantation, Autologous; D014655:Vascular Resistance / Q000187:drug effects*
D011955:Receptors, Drug; D004298:Dopamine; D010646:Phentolamine
Die Wirkung von Dopamin im Pulmonalkreislauf der innervierten und autotransplantierten Lunge