Polyarthritis, hepatitis and anti-native DNA antibodies after treatment with ethambutol and rifampicin.
After seven months' continuous treatment for suspected tuberculosis with rifampicin and ethambutol a nine-year-old boy developed polyarthritis, rash and hepatitis in association with anti-native DNA antibodies and positive antinuclear factor. Six weeks after withdrawal of the antituberculosis drugs and conservative management, the boy was clinically well and ten months later he remained well clinically and liver function tests, anti-DNA antibody and antinuclear factor tests were normal.
D000906:Antibodies / Q000032:analysis*; D000974:Antibodies, Antinuclear; D000918:Antibody Specificity; D002648:Child; D004247:DNA / Q000276:immunology*; D004977:Ethambutol / Q000009:adverse effects*; D006801:Humans; D008297:Male; D009164:Mycobacterium Infections / Q000188:drug therapy*; D012293:Rifampin / Q000009:adverse effects* / Q000627:therapeutic use*
D000906:Antibodies; D000974:Antibodies, Antinuclear; D004977:Ethambutol; D004247:DNA; D012293:Rifampin