Transformation of mouse cells by fusion with chronic granulocytic leukemia cells: possible role of human chromosome.
In vitro properties of somatic cell hybrids between non-malignant B82 mouse fibroblasts and human chronic granulocytic leukemia spleen cells include lack of cell density-dependent growth inhibition and growth in soft agar. These phenotypic expressions of cell transformation appear linked to the retention by the cells of chromosome 7 from the human leukemic genome.
D000818:Animals; D002459:Cell Fusion; D002471:Cell Transformation, Neoplastic; D002906:Chromosomes, Human, 6-12 and X; D005347:Fibroblasts; D006801:Humans; D006822:Hybrid Cells; D066298:In Vitro Techniques; D007621:Karyotyping; D007951:Leukemia, Myeloid / Q000235:genetics*; D051379:Mice