Experimental allergic encephalomyelitis.-- The effect of dexamethasone on growth and proliferation in the draining lymph node.
Dexamethasone, when administered from day 0 to day 9 following the sensitizing injection of encephalitogenic protein in complete Freund's adjuvant, suppressed both the characteristic enlargement of the paracortical area of the draining lymph node and the development of clinical and histopathological signs of experimental allergic encephalomyelitis. Division of cells within the node was not inhibited and therefore the effect of dexamethasone appeared to be a consequence of reduced migration of lymphocytes into the node.
D000818:Animals; D003907:Dexamethasone / Q000494:pharmacology*; D004681:Encephalomyelitis, Autoimmune, Experimental / Q000473:pathology / Q000503:physiopathology*; D005260:Female; D008198:Lymph Nodes / Q000187:drug effects* / Q000473:pathology / Q000503:physiopathology; D009929:Organ Size / Q000187:drug effects; D051381:Rats; D011917:Rats, Inbred Lew; D013116:Spinal Cord / Q000473:pathology
D003907:Dexamethasone