Side-effects of local anesthetics on the corneal epithelium of the rabbit eye.
The toxic side-effects of 0.4% Novesine and Chibro-Kerakain were investigated by scanning- and transmission electron microscopy in 15 rabbit corneae each in intervals of 3, 6, 10, 15 and 60 mins. The lesions following Kerakain were larger and occurred earlier. After 60 mins, the specimens after Novesine application showed an almost complete repair process, whereas after Kerakain the epithelial surface appeared to be functionally impaired.
D000779:Anesthetics, Local / Q000633:toxicity*; D000818:Animals; D001548:Benzalkonium Compounds / Q000494:pharmacology; D003315:Cornea / Q000187:drug effects*; D008854:Microscopy, Electron; D008855:Microscopy, Electron, Scanning; D011817:Rabbits; D012038:Regeneration
D000779:Anesthetics, Local; D001548:Benzalkonium Compounds