[The effect of sympatholytics and adrenergic receptor blockade on the histophysiology of the insular apparatus of the pancreas and insulin sensitivity of white rats].
Experiments were conducted on 200 male albino rats.  It was shown that prolonged administration of sympatholytics (ornide or actadine) and also of a blocker of the alpha-adrenorecptors with phentholamine or of beta-adrenoreceptors with inderal led to the accumulation of zinc in the cytoplasm of beta-cells, reduction of the content in them of specific aldehyde-fuchsinophilic granularity, neoformation of the islands of Langerhans and to increase in the animal sensitivity to the exogenous insulin.
D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D001949:Bretylium Compounds / Q000494:pharmacology; D006145:Guanethidine / Q000494:pharmacology; D007515:Islets of Langerhans / Q000187:drug effects*; D008297:Male; D010646:Phentolamine / Q000494:pharmacology; D011433:Propranolol / Q000494:pharmacology; D051381:Rats; D013565:Sympatholytics / Q000494:pharmacology*
D001786:Blood Glucose; D001949:Bretylium Compounds; D013565:Sympatholytics; D011433:Propranolol; D010646:Phentolamine; D006145:Guanethidine
Vliianie simpatolitikov i blokady adrenergicheskikh retseptorov na gistofiziologiiu insuliarnogo apparata podzheludochnoĭ zhelezy i chuvstvitel'nost' k insulinu u belykh krys