title: Synthesis of octopamine by insect dorsal median unpaired neurons.
abstract: Dorsal unpaired median (DUM) neurons of locusts and grasshoppers inhibit the instrinsic rhythm of contraction of metathoracic extensor tibia muscle fibers. This physiological action is mimicked by very low concentrations of octopamine and by higher concentrations of dopamine and noradrenaline. We have examined the synthesis of biogenic amines from tritiated tyrosine by these neurons. DUM cell bodies and a peripheral nerve containing the DUM axon which terminates in the extensor tibia both produced octopamine, but neither noradrenaline nor dopamine synthesis was detected. The observations support the suggestion that the dorsal unpaired median neurons are octopaminergic.
mesh_terms: D000818:Animals; D005724:Ganglia / Q000378:metabolism; D006110:Grasshoppers / Q000378:metabolism; D009474:Neurons / Q000378:metabolism*; D009655:Octopamine / Q000096:biosynthesis*; D009987:Orthoptera / Q000378:metabolism*; D014439:Tyramine / Q000378:metabolism; D014443:Tyrosine / Q000378:metabolism
chemical_list: D009655:Octopamine; D014443:Tyrosine; D014439:Tyramine