Class differences in the antibody response of HLC and LLC mice to sheep red blood cells.
The immune response to sheep red blood cells (SRBC) has been studied in two mouse lines selectively bred for a difference in leukocyte levels. Low leukocyte count (LLC) mice responded to multiple injections of 4 x 10(7) SRBC with a predominant IgM response whereas high leukocyte count (HLC) mice produced IgG almost exclusively, even after a single injection of SRBC. F1 mice responded like the LLC parent and backcross data implied genetic control at multiple loci. No correlation was found between the class of antibody produced in response to SRBC and the leukocyte count in backcross mice. Large numbers of plaque-forming cells (PFC) were detected in the spleens of HLC mice relative to the number detected in LLC spleens after primary and secondary immunizations with SRBC.
D000818:Animals; D000917:Antibody Formation; D000921:Antibody-Producing Cells; D003433:Crosses, Genetic; D004912:Erythrocytes / Q000276:immunology; D005260:Female; D006461:Hemolysis; D006462:Hemolytic Plaque Technique; D007106:Immune Sera; D007074:Immunoglobulin G; D007075:Immunoglobulin M; D007958:Leukocyte Count; D007962:Leukocytes; D008297:Male; D008623:Mercaptoethanol; D051379:Mice; D008815:Mice, Inbred Strains; D012756:Sheep / Q000276:immunology
D007106:Immune Sera; D007074:Immunoglobulin G; D007075:Immunoglobulin M; D008623:Mercaptoethanol