title: [Early functional disorders in 3 children exhibiting an obstructive syndrome and an alpha 1 antitrypsin deficiency].
abstract: The respiratory function is studied in 3 children, two of which 4 years in age, exhibiting a respiratory obstructive syndrome and an alpha1-antitrypsin deficiency. The study of the respiratory function is global and regional. The disorders noted include a ventilatory asynchronism, a distension, regional anomalies of ventilation and perfusion. The ventilatory asynchronism appears to be an early disorder in the course of alpha1-antitrypsin deficiency. These results have to be related with the development of the elastic fibers during the child's growth.
mesh_terms: D002648:Child; D002675:Child, Preschool; D006801:Humans; D008168:Lung / Q000503:physiopathology; D008173:Lung Diseases, Obstructive / Q000503:physiopathology*; D008176:Lung Volume Measurements; D011653:Pulmonary Diffusing Capacity; D012119:Respiration; D012129:Respiratory Function Tests; D019896:alpha 1-Antitrypsin Deficiency
vernacular_title: Perturbations fonctionnelles précoces chez 3 enfants ayant un syndrome obstructif et un déficit en alpha1-antitrypsine