title: [Experimental and clinical study of d, 1-oxyphedrin].
abstract: Comparative pharmacological and toxicological studies were carried out on animals covering the preparation d,1-oxyphedrine (myophedrine), put out in the GDR, as against the drug 1-oxyphedrine. The activity of both drugs showed no material difference. Clinical trials demonstrated good tolerance of the drug both by healthy persons and patients with its intravenous administration twice a day in amounts of 1 mg, or by mouth--3 times a day in amounts of 8--16 mg. In outpatients with anginal pains after sustained myocardial infarction and also in institutionally treated patients with myocardial infarction the activity of d,1-oxyphedrine proved to be not inferior to that of 1-oxyphedrine.
mesh_terms: D000328:Adult; D000368:Aged; D000553:Ambulatory Care; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D002986:Clinical Trials as Topic; D004285:Dogs; D004305:Dose-Response Relationship, Drug; D005260:Female; D006168:Guinea Pigs; D006339:Heart Rate / Q000187:drug effects; D006760:Hospitalization; D006801:Humans; D066298:In Vitro Techniques; D007928:Lethal Dose 50; D008297:Male; D051379:Mice; D008875:Middle Aged; D009203:Myocardial Infarction / Q000188:drug therapy; D010099:Oxyfedrine / Q000009:adverse effects / Q000494:pharmacology*; D011427:Propiophenones / Q000494:pharmacology*; D051381:Rats; D013997:Time Factors
chemical_list: D011427:Propiophenones; D010099:Oxyfedrine
vernacular_title: Eksperimental'noe i klinicheskoe izuchenie d, 1-oksifedrina