[Study of the effect of nystatin and mycoheptin on the intrauterine development of the rat fetus].
The effect of nystatin and mycoheptyne on pregnancy and fetus of rats of Wister line was studied after single and multiple oral administrations of the drugs. Nystatin was used in single doses of 3000, 500 and 100 mg/kg. In chronic experiments the dose was 500 mg/kg. It was found that nystatin had a slight abortive effect when used during the whole period of pregnancy. Mycoheptyne was used in single doses of 1000, 100 and 20 mg/kg. In chronic experiments the dose was 100 mg/kg. It was noted that mycoheptyne had a higher toxic effect on the pregnant rats than nystatin. The animal death and abortus were observed more often. The level of the changes depended on the dose, time and period of the antibiotic use. No defects in the rat fetus were found.
D000014:Abnormalities, Drug-Induced / Q000473:pathology; D000284:Administration, Oral; D000818:Animals; D000935:Antifungal Agents / Q000494:pharmacology* / Q000633:toxicity; D002266:Carboxymethylcellulose Sodium / Q000008:administration & dosage; D003338:Corpus Luteum / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D010064:Embryo Implantation / Q000187:drug effects; D005260:Female; D005313:Fetal Death / Q000139:chemically induced; D005333:Fetus / Q000187:drug effects*; D006652:Histological Techniques; D009761:Nystatin / Q000494:pharmacology* / Q000633:toxicity; D011247:Pregnancy; D051381:Rats; D013997:Time Factors
D000935:Antifungal Agents; D009761:Nystatin; D002266:Carboxymethylcellulose Sodium
Issledovanie vliianiia nistatina i mikogeptina na vnutriutrobnoe razvitie ploda krysy