Polynucleotide analogs: acrylic acid and maleic acid copolymers of 1-vinyluracil and 9-vinyladenine.
Radical-induced copolymerization of 1-vinyluracil and maleic anhydride gave, after hydrolysis, a polymer containing a 1:1 monomer ratio of 1-vinyluracil-maleic acid. Gamma-Ray-induced copolymerization of 1-vinyluracil with acrylic acid gave a polymer with a ratio of 1:1.7. Similar treatment of 9-vinlyadenine and acrylic acid resulted in a polymer with a 1:3.2 ratio. These three compounds are potent stimulants of poly (uridylic acid) coded polyphenylalanine synthesis in an in vitro cell free system purified from Escherichia coli MRE 600. The double-stranded polymer, poly(inosinic acid)-poly(cytidylic acid), also stimulates polyphenylalanine synthesis in this assay.
D000225:Adenine / Q000031:analogs & derivatives*; D001665:Binding Sites; D004926:Escherichia coli / Q000378:metabolism; D007700:Kinetics; D009690:Nucleic Acid Conformation; D011061:Poly A; D011070:Poly I-C; D011072:Poly U; D011119:Polynucleotides; D014176:Protein Biosynthesis; D012270:Ribosomes / Q000378:metabolism; D013056:Spectrophotometry, Ultraviolet; D013329:Structure-Activity Relationship; D014498:Uracil / Q000031:analogs & derivatives*; D014753:Vinyl Compounds
D011119:Polynucleotides; D014753:Vinyl Compounds; D011061:Poly A; D011072:Poly U; D014498:Uracil; D000225:Adenine; D011070:Poly I-C