Preliminary studies on the prolongation of the survival of mouse skin allografts cultured on a solid medium.
Skin allografts were transferred between individuals of white Swiss mice. No first set reaction was observed, but a second set reaction which resulted in accelerated rejection of the graft, could be induced by a second graft transplanted 2 weeks after the first. However, the histoincompatibility of the graft which causes the rejection, could be temporarily weakened when a graft had been cultured "in vitro" for at least 6 weeks prior to grafting. Nevertheless, histocompatibility differences between two different species e.g. man and mouse, could not be weakened at all by the tissue culture method.
D000293:Adolescent; D000328:Adult; D000368:Aged; D000818:Animals; D002648:Child; D002675:Child, Preschool; D003470:Culture Media; D046508:Culture Techniques; D006084:Graft Rejection; D006648:Histocompatibility; D006801:Humans; D008297:Male; D051379:Mice; D008875:Middle Aged; D016038:Skin Transplantation; D013997:Time Factors; D014181:Transplantation Immunology; D014183:Transplantation, Heterologous; D014184:Transplantation, Homologous
D003470:Culture Media