Pyloric reflux gastritis: the offending agent.
Tubes of canine gastric corpus were constructed so that the mucosa was exposed chronically to jejunal contents, pancreatic juice, or bile. Biopsies of these mucosae obtained 4 to 24 months later were compared with each other and with the normal stomach for parietal cell numbers, mucus cell numbers, inflammation, glandular disorder, and surface-cell hyperplasia. All three preparations showed marked gastrititis, but whole jejunal contents caused more severe changes than did either pancreatic juice or bile, which were approximately equal.
D000818:Animals; D001646:Bile / Q000502:physiology*; D004285:Dogs; D005753:Gastric Mucosa / Q000166:cytology / Q000503:physiopathology*; D005756:Gastritis / Q000503:physiopathology*; D005764:Gastroesophageal Reflux / Q000503:physiopathology; D006801:Humans; D006965:Hyperplasia / Q000503:physiopathology; D007419:Intestinal Secretions / Q000502:physiology*; D007583:Jejunum; D010189:Pancreatic Juice / Q000502:physiology*; D010437:Peptic Ulcer / Q000503:physiopathology; D011178:Postgastrectomy Syndromes / Q000503:physiopathology; D011706:Pyloric Antrum / Q000166:cytology / Q000503:physiopathology; D051381:Rats