[Mechanism of the effect of sera from rats subjected to high external temperature on rosette formation by splenic lymphocytes from non-immune animals].
Serum of rats subjected to the action of moderately high external temperature increased the immunogenicity of heterologous erythrocytes, but became inactive at a temperature of 2 degrees C and after the treatment with a polyvalent proteinase inhibitor--trasilol. Incubation of sheep erythrocytes with the serum of heated rats intensified the reaction of rosette formation by the lymphocytes of the spleen of intact rats. Incubation of the spleen cells with the sera of intact and heated rats failed to influence the rosette formation. After trasilol treatment the serum of heated rats completely lost the property to intensify the reaction of rosette formation. Phenomenon of intensification of rosette formation was revealed in case of treatment of erythrocytes with the sera at a temperature of 37 degrees C and was not reproduced at a temperature of 2 degrees C. Investigations carried out indicated that the increase in the immunogenicity of sheep erythrocytes and the intensification of their binding with the lymphocyte receptors of intact rats under the effect of the serum of heated animals were caused by the action of the same factor.
D000818:Animals; D007611:Aprotinin; D006358:Hot Temperature; D007104:Immune Adherence Reaction; D007106:Immune Sera / Q000494:pharmacology*; D008214:Lymphocytes / Q000276:immunology*; D051381:Rats; D013154:Spleen / Q000276:immunology*
D007106:Immune Sera; D007611:Aprotinin
O mekhanizme vliianiia syvorotki krys, podvergnutykh deĭstviiu vysokoĭ vneshneĭ temperatury, na obrazovanie rozetok limfotsitami selezenki neimmunykh zhivotnykh