Adrenocortical function related to Althesin anaesthesia and surgery in man.
Althesin anaesthesia alone had no significant effect on plasma cortisol concentration. When Althesin induction was followed by maintenance with N2O and halothane there was a statistically insignificant fall, but with N2O, pancuronium and I.P.P.V there was a tendency for plasma cortisol concentrations to rise. This, too, was statistically not significant. A significant elevation in the mean plasma cortisol concentration was only found in patients during abdominal surgery.
D000005:Abdomen / Q000601:surgery; D000293:Adolescent; D000302:Adrenal Cortex / Q000187:drug effects*; D000311:Adrenal Glands / Q000187:drug effects*; D000328:Adult; D000368:Aged; D000530:Alfaxalone Alfadolone Mixture / Q000494:pharmacology*; D000771:Anesthesia, Intravenous; D002986:Clinical Trials as Topic; D005260:Female; D006221:Halothane / Q000494:pharmacology; D006801:Humans; D006854:Hydrocortisone / Q000097:blood; D008875:Middle Aged; D013511:Minor Surgical Procedures; D009609:Nitrous Oxide / Q000494:pharmacology; D010197:Pancuronium / Q000494:pharmacology; D011175:Positive-Pressure Respiration; D011277:Pregnanediones / Q000494:pharmacology*; D013312:Stress, Physiological; D013514:Surgical Procedures, Operative
D011277:Pregnanediones; D000530:Alfaxalone Alfadolone Mixture; D010197:Pancuronium; D009609:Nitrous Oxide; D006221:Halothane; D006854:Hydrocortisone