T cell-dependent mediator in the immune response. III. The role of non-specific factor (NSF) in the in vitro immune response.
Evidence is presented which suggests that T cell-dependent nonspecific factor (NSF) cannot be the sole mediator of 'co-operation' for all types of thymus-dependent antibody response. NSF can replace the requirement for T cells in responses to hapten conjugated to particulate carriers, but cannot do so in responses to hapten conjugates of soluble thymus-dependent carriers.
D000818:Animals; D000906:Antibodies; D000917:Antibody Formation; D000918:Antibody Specificity; D000921:Antibody-Producing Cells; D000937:Antigen-Antibody Reactions; D000941:Antigens / Q000032:analysis; D002352:Carrier Proteins; D002478:Cells, Cultured; D004912:Erythrocytes / Q000276:immunology; D005620:Freund's Adjuvant; D006241:Haptens; D006462:Hemolytic Plaque Technique; D007109:Immunity; D007114:Immunization; D051379:Mice; D008808:Mice, Inbred CBA; D011485:Protein Binding; D012756:Sheep / Q000276:immunology; D013601:T-Lymphocytes / Q000276:immunology*
D000906:Antibodies; D000941:Antigens; D002352:Carrier Proteins; D006241:Haptens; D005620:Freund's Adjuvant