Thymosin restores T cell function and reduces the incidence of amyloid disease in casein-treated mice.
Evidence is presented that T cell impairment appears to be specifically related to the pathogenesis of experimental amyloidosis. This conclusion is based on the finding that thymosin administration improves T cell function as measured by mitogen stimulation of spleen cell suspension and at the same time reduces the incidence and severity of amyloid disease in casein-treated mice.
D000686:Amyloidosis / Q000139:chemically induced / Q000175:diagnosis / Q000188:drug therapy*; D000818:Animals; D002364:Caseins; D008213:Lymphocyte Activation; D051379:Mice; D008808:Mice, Inbred CBA; D013601:T-Lymphocytes / Q000503:physiopathology*; D013947:Thymosin / Q000627:therapeutic use*; D013949:Thymus Extracts / Q000627:therapeutic use*
D002364:Caseins; D013949:Thymus Extracts; D013947:Thymosin