title: Unusual sensitivity of Escherichia coli to adenine or adenine plus histidine.
abstract: The W3110 strain of Escherichia coli K-12 is unusually sensitive to adenine. Inhibition of growth is relieved by a combination of thiamine and uridine (or cytidine). In the presence of histidine, inhibition is more severe and is relieved by a combination of thiamine, glycine, uridine (or cytidine), and inosine (or guanosine).
mesh_terms: D000225:Adenine / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D003562:Cytidine / Q000494:pharmacology; D004347:Drug Interactions; D004926:Escherichia coli / Q000187:drug effects* / Q000254:growth & development; D005998:Glycine / Q000494:pharmacology; D006151:Guanosine / Q000494:pharmacology; D006639:Histidine / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D007288:Inosine / Q000494:pharmacology; D008826:Microbial Sensitivity Tests; D009154:Mutation; D013045:Species Specificity; D013831:Thiamine / Q000494:pharmacology; D014529:Uridine / Q000494:pharmacology
chemical_list: D006151:Guanosine; D006639:Histidine; D007288:Inosine; D003562:Cytidine; D000225:Adenine; D005998:Glycine; D014529:Uridine; D013831:Thiamine