The effect of platelet function inhibitors on experimental venous thrombosis formation in rabbits.
Inhibitors of the platelet functions, collagen-induced aggregation and release reaction (ASA and sulfinpyrazone) and ADP-induced aggregation (dipyridamole and VK 744), were investigated as potential preventive agents against venous thrombosis formation in rabbits. An experimental model combining endothelial damage (sodium morrhuate) and controlled stasis of the femoral venous flow was used. None of the agents showed any significant protective effect against venous thrombosis, a finding which is in keeping with the results of recent clinical investigation.
D000244:Adenosine Diphosphate / Q000494:pharmacology; D000818:Animals; D001241:Aspirin / Q000494:pharmacology; D001792:Blood Platelets / Q000187:drug effects*; D002986:Clinical Trials as Topic; D003094:Collagen / Q000494:pharmacology; D004176:Dipyridamole / Q000494:pharmacology; D005260:Female; D008297:Male; D010973:Platelet Adhesiveness / Q000187:drug effects*; D010974:Platelet Aggregation / Q000187:drug effects*; D011817:Rabbits; D013442:Sulfinpyrazone / Q000494:pharmacology; D013924:Thrombophlebitis / Q000517:prevention & control*; D014325:Tromethamine / Q000494:pharmacology
D014325:Tromethamine; D000244:Adenosine Diphosphate; D004176:Dipyridamole; D003094:Collagen; D001241:Aspirin; D013442:Sulfinpyrazone