Occult gastrointestinal bleeding due to aspirin: comparison of two compounds.
Occult gastrointestinal bleeding as measured by the faecal 51Cr-labelled red-cell loss was compared in eight healthy volunteers while on therapeutic doses of soluble aspirin and a new slow-release formulation of aspirin (Deskoval). While both preparations led to increased faecal blood loss, this was significantly less during administration of Deskoval than when soluble aspirin was taken.
D001241:Aspirin / Q000008:administration & dosage / Q000009:adverse effects*; D002860:Chromium Radioisotopes; D004912:Erythrocytes / Q000378:metabolism; D006471:Gastrointestinal Hemorrhage / Q000139:chemically induced*; D006801:Humans; D008551:Melena / Q000175:diagnosis; D009780:Occult Blood; D013608:Tablets, Enteric-Coated
D002860:Chromium Radioisotopes; D013608:Tablets, Enteric-Coated; D001241:Aspirin