Blood-brain barrier lesions in acute hypertension in rabbits after unilateral X-ray exposure of brain.
Acute hypertension was induced by metaraminol at different time intervals following irradiation in rabbits exposed to unilateral X-ray irradiation against the brain (3000 R) and in control animals. Hypertension resulted in a few areas of Evans blue extravasation in control animals. In the irradiated animals there was a marked increase in tracer extravasation on the half of the brain exposed to X-rays, indicating an increased vulnerability of cerebral vessels to blood pressure increase after irradiation.
D000208:Acute Disease; D000818:Animals; D001812:Blood-Brain Barrier / Q000528:radiation effects*; D001921:Brain / Q000528:radiation effects; D002199:Capillary Permeability / Q000528:radiation effects; D002543:Cerebral Hemorrhage / Q000209:etiology; D002560:Cerebrovascular Circulation / Q000528:radiation effects; D004395:Dye Dilution Technique; D006973:Hypertension / Q000139:chemically induced / Q000503:physiopathology*; D008680:Metaraminol / Q000494:pharmacology; D011817:Rabbits; D011833:Radiation Injuries, Experimental; D014965:X-Rays
D008680:Metaraminol