Hyperosmolar nonketotic syndrome and steroid diabetes. Occurrence after renal transplantation.
So-called steroid (glucocorticoids) diabetes developed in 11 (5.5%) of 202 patients receiving 216 renal allografts between December 1963 and June 1974. In three of the 11 patients, hyperosmolar nonketotic syndrome was present at diagnosis; all of the three recovered. Eight of the 11 patients survived with functioning allografts, and only one of the eight requires insulin. Hyperglycemia has been detected in most transplant patients tested in the immediate postoperative period. Factors (including stress from surgery and treatment with drugs such as furosemide) predispose to this condition.
D000293:Adolescent; D000328:Adult; D001786:Blood Glucose / Q000032:analysis; D003241:Consanguinity; D003920:Diabetes Mellitus / Q000139:chemically induced* / Q000188:drug therapy; D005260:Female; D005938:Glucocorticoids / Q000008:administration & dosage / Q000009:adverse effects*; D006801:Humans; D006943:Hyperglycemia / Q000175:diagnosis*; D007166:Immunosuppressive Agents / Q000009:adverse effects; D007275:Injections, Intravenous; D007328:Insulin / Q000627:therapeutic use; D016030:Kidney Transplantation; D008297:Male; D008875:Middle Aged; D009392:Nephrectomy; D011183:Postoperative Complications; D013156:Splenectomy; D013577:Syndrome; D013997:Time Factors; D014184:Transplantation, Homologous
D001786:Blood Glucose; D005938:Glucocorticoids; D007166:Immunosuppressive Agents; D007328:Insulin