Dissociation between indices of pump performance and contractility in patients with coronary artery disease and acute myocardial infarction.
An analysis of ventricular performance comparing pump function and muscle function indices was performed in 13 patients with acute myocardial infarction, ten patients with normal coronary arteries, and 15 patients with coronary artery disease. Pump function was described by plotting left ventricular stroke work index as a function of left ventricular end diastolic pressure. This description provided a clear separation between normal patients, and surviving and nonsurviving patients with acute myocardial infarction. Values of contractile element velocity (VCE5 as an estimate of Vmax) did not separate between normals and surviving or nonsurviving patients with acute myocardial infarction. In 15 patients with acute coronary artery disease there was no correlation between values of VCE5 and the ventricular function curve. Changes in performance following the stress of ventriculography, angiotensin infusion, or isometric hand grip exercise also did not show any correlation between pump function and muscle function indices. It is concluded that pump function indices are a better indicator of ventricular performance in patients with acute myocardial infarction and coronary artery disease.
D000208:Acute Disease; D000790:Angiocardiography; D000804:Angiotensin II; D001794:Blood Pressure; D006328:Cardiac Catheterization; D002302:Cardiac Output; D003327:Coronary Disease / Q000503:physiopathology*; D005080:Exercise Test; D006321:Heart / Q000503:physiopathology*; D006339:Heart Rate; D006352:Heart Ventricles / Q000503:physiopathology; D006801:Humans; D007201:Indicator Dilution Techniques; D008954:Models, Biological; D009203:Myocardial Infarction / Q000503:physiopathology*
D000804:Angiotensin II