Glucocorticoid and antibiotic effect on experimental gram-negative bacteremic shock.
This study was designed to answer the three following questions: (1) Are glucocorticoids as protective in Gram-negative bacteremic shock as they are in endotoxic shock? (2) Is there any difference in efficacy between a bacteriostatic and a bactericidal antibiotic in bacteremic shock? (3) Does the combination of glucocorticoid with antibiotic potentiate the individual protective effects of both? Bacteremia was induced in male Sprague-Dawley rats by a single intravenous injection of viable Escherichia coli. The results showed that dexamethasone sodium phosphate alone afforded significant protection against Gram-negative bacteremic shock up to eight hours after challenge. The choice of a bactericidal vs a bacteriostatic antibiotic did not influence the survival rates in this study. The survival rate was maximal when dexamethasone was used with both ampicillin sodium and gentamicin sulfate.
D000667:Ampicillin / Q000627:therapeutic use*; D000818:Animals; D002701:Chloramphenicol / Q000627:therapeutic use; D003907:Dexamethasone / Q000494:pharmacology / Q000627:therapeutic use*; D004926:Escherichia coli / Q000187:drug effects; D005839:Gentamicins / Q000627:therapeutic use; D006801:Humans; D008297:Male; D010400:Penicillin G / Q000627:therapeutic use; D051381:Rats; D012772:Shock, Septic / Q000517:prevention & control*; D013307:Streptomycin / Q000627:therapeutic use; D013924:Thrombophlebitis / Q000150:complications / Q000517:prevention & control / Q000601:surgery*
D005839:Gentamicins; D002701:Chloramphenicol; D000667:Ampicillin; D003907:Dexamethasone; D010400:Penicillin G; D013307:Streptomycin