The immunogenicity of fresh and frozen allogeneic bone.
Both fresh and frozen allogeneic bone elicit both acellular and humoral immune response. This response includes the development of enhancing factors which block detectable immunity and probably protect the graft from rejection. There seems to be no evidence of an alteration in immunogenicity by freezing of the graft. The importance of these observations lies in the potential technique of employing fresh viable allografts; prior freezing and tissue matching for HL-A transplantation antigens should not be necessary.
D000818:Animals; D000906:Antibodies / Q000032:analysis; D000917:Antibody Formation; D016025:Bone Transplantation; D001842:Bone and Bones / Q000473:pathology; D002464:Cell Migration Inhibition; D003601:Cytotoxicity Tests, Immunologic; D006084:Graft Rejection; D007111:Immunity, Cellular; D007962:Leukocytes / Q000276:immunology; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D016038:Skin Transplantation; D013997:Time Factors; D014021:Tissue Preservation; D014184:Transplantation, Homologous
D000906:Antibodies