Control of salmonellosis pacifarin biosynthesis by iron.
Enterobacter cloacae strain SS4-56 produced salmonellosis pacifarins when grown in an iron-depleted synthetic medium to which 3.16 X 10-7 g-atom of iron had been added per liter, but did not do so when grown in iron-depleted medium supplemented with 3.16 X 10-4 g-atom of iron per liter. The addition of 3.16 X 10-4 g-atom of ferric iron per liter to a pacifarin-containing culture supernatant fluid had no significant effect upon the ability of the active pacifarins present, when administered per os, to protect mice from an otherwise fatal infection produced by a sequential injection of avirulent and virulent strains of Salmonella typhimurium.
D000821:Animal Feed; D000818:Animals; D002396:Catechols / Q000031:analogs & derivatives* / Q000096:biosynthesis; D003124:Colorimetry; D003470:Culture Media; D004755:Enterobacteriaceae / Q000378:metabolism*; D007501:Iron / Q000494:pharmacology*; D007773:Lactates; D051379:Mice; D012486:Salmonella typhimurium / Q000276:immunology*; D014774:Virulence
D002396:Catechols; D003470:Culture Media; D007773:Lactates; C008752:pacifarin; D007501:Iron