title: Lymphocyte trapping. Differential effects of ATS and irradiation on trapping in lymph nodes and spleen.
abstract: Increased sequestration (trapping) of lymphocytes occurs in lymphoid organs following antigenic challenge. The effects of irradiation and anti-thymocyte serum (ATS) upon lymphocyte trapping in lymph nodes and spleen were studied. Both the above agents diminished or abrogated trapping in the draining lymph nodes; these same agents resulted in enhanced trapping in the spleen. Suppression of lymph node trapping could be achieved with a low dose of ATS and with 850 R, but not 200 R. These results are interpreted as showing that lymphocyte trapping in lymph nodes is initiated primarily by an ATS- and irradiation-sensitive population, whereas in the spleen a cell population resistant to the above agents activates the lymphocyte trap. These data demonstrate that the cell populations and/or the mechanisms involved in lymphocyte trapping in lymph nodes and spleens are distinct.
mesh_terms: D000818:Animals; D000961:Antilymphocyte Serum / Q000494:pharmacology*; D005260:Female; D008198:Lymph Nodes / Q000276:immunology* / Q000528:radiation effects; D008214:Lymphocytes / Q000276:immunology* / Q000528:radiation effects; D008297:Male; D051379:Mice; D011830:Radiation Effects; D013154:Spleen / Q000276:immunology* / Q000528:radiation effects; D013601:T-Lymphocytes / Q000276:immunology
chemical_list: D000961:Antilymphocyte Serum