Abscopal effect of irradiation on haemopoietic stem cells of shielded bone marrow--role of migration.
Immediately after partial-body irradiation, the number of colony-forming units (CFU) of the protected marrow decreases. This decrease seems to be dose-dependent and cannot be completely explained by migration for the following reasons: there is no evidence of CFU entry to irradiated territories and the number of circulating CFU does not increase. A more plausible explanation for the phenomena is an accelerated differentiation during the first 15 min after irradiation. The migration of CFU to the spleen is observed between 15 min and 3 hours after irradiation, after which it ceases. The absence of migration 3 hours after irradiation may be due to one of the two possibilities: (1) a depletion of the mobile pool of CFU if one admits that such a pool is responsible for migration in the organism; (2) a depletion of a temporarily increased stimulus due to irradiation.
D000818:Animals; D001853:Bone Marrow / Q000503:physiopathology*; D002465:Cell Movement; D003037:Cobalt Radioisotopes; D004307:Dose-Response Relationship, Radiation; D004601:Elementary Particles; D005260:Female; D006412:Hematopoietic Stem Cells / Q000503:physiopathology*; D051379:Mice; D008809:Mice, Inbred C3H; D011833:Radiation Injuries, Experimental / Q000503:physiopathology*; D013154:Spleen / Q000503:physiopathology; D014965:X-Rays
D003037:Cobalt Radioisotopes