The potential of localized heating as a adjunct to radiation therapy.
Experimental studies have shown that (a) tumor cells may be more sensitive to heat than normal cells; (b) hyperthermia inactivates cellular repair mechanisms for radiation damage; and (c) heat may lower the OER for ionizing radiation (anoxic cells are at least as sensitive to hyperthermia as oxygenated cells). Localized hyperthemia produced by localized current fields in the range of 100 kHz-10 MHz by direct contact electrodes offers two major advantages: the eletrode configurations may be manipulated to obtain desired thermal dose distributions, and, since the mode of heating is essentially instantaneous, accurate temperature control can be maintained during treatment.
D000293:Adolescent; D000818:Animals; D001859:Bone Neoplasms / Q000532:radiotherapy / Q000628:therapy; D002460:Cell Line; D002470:Cell Survival; D002648:Child; D004560:Electricity; D005260:Female; D006367:HeLa Cells; D006358:Hot Temperature / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D008545:Melanoma / Q000532:radiotherapy / Q000628:therapy; D009368:Neoplasm Transplantation; D009369:Neoplasms / Q000532:radiotherapy / Q000628:therapy*; D009374:Neoplasms, Experimental / Q000532:radiotherapy / Q000628:therapy; D012516:Osteosarcoma / Q000532:radiotherapy / Q000628:therapy; D010100:Oxygen; D011878:Radiotherapy / Q000379:methods*; D012510:Sarcoma 180 / Q000532:radiotherapy / Q000628:therapy
D010100:Oxygen