title: [Karyometric studies of the pancreas and adrenal glands of the albino-rat fed an unbalanced glucose diet or a glucose diet supplemented with thiamine].
abstract: Karyometric measurements in rats which for 30 days had received a glucose diet or a glucose diet supplemented with thiamine showed the following decrease in nuclear size in contrast to no treated controls. (see article) In both experimental groups there was a 30% loss of weight during the course of the experiment. The different decreases in nuclear volume in the examined organs cannot be explained only by a relative state of hunger. The very large decrease in activity in the fasciculated zone of the adrenal cortex is explained as an adaptation mechanism favouring glucose oxidation by insulin, and the relative increase in activity in the adrenal medulla as an adaptation mechanism to accomplish an elevated lipolysis.
mesh_terms: D000302:Adrenal Cortex / Q000187:drug effects / Q000648:ultrastructure; D000311:Adrenal Glands / Q000187:drug effects*; D000313:Adrenal Medulla / Q000187:drug effects / Q000648:ultrastructure; D000818:Animals; D001835:Body Weight; D002467:Cell Nucleus / Q000187:drug effects* / Q000648:ultrastructure; D004032:Diet; D005947:Glucose / Q000494:pharmacology*; D007515:Islets of Langerhans / Q000187:drug effects / Q000648:ultrastructure; D007620:Karyometry; D008297:Male; D010179:Pancreas / Q000187:drug effects* / Q000648:ultrastructure; D051381:Rats; D013831:Thiamine / Q000494:pharmacology*
chemical_list: D005947:Glucose; D013831:Thiamine
vernacular_title: Karyometrische Untersuchungen an Pankreas und Nebenniere der Albinoratte bei einseitiger Glucose- und Glucose-Thiamin-Diät