The influence of treatment of the paralesional skin with dithranol on healing in psoriasis.
Application of dithranol confined to the normal skin surrounding thirty-six psoriatic lesions produced improvement in twenty-four lesions, which was significantly more than the improvement noted in four of thirty-six control lesions left untreated. Such healing was temporary and slower than in lesions treated conventionally. It is suggested that the apparently normal skin around a psoriatic lesion under treatment influences the psoriasis.
D000287:Administration, Topical; D000293:Adolescent; D000328:Adult; D000368:Aged; D000873:Anthracenes / Q000627:therapeutic use*; D000875:Anthralin / Q000008:administration & dosage / Q000627:therapeutic use*; D002986:Clinical Trials as Topic; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011565:Psoriasis / Q000188:drug therapy*; D012008:Recurrence
D000873:Anthracenes; D000875:Anthralin