Influenza virus infection in nude mice.
The role of T-cell function in influenza virus infection was studied by aerosol infection of nude mice with an influenza A virus (PR-8 strain). Nude mice died somewhat later than normal mice, and the antibody response of nude mice to the virus was minimal. Furthermore, nude mice did not eliminate the virus, which persisted for relatively long periods (two to three weeks).
D000818:Animals; D000917:Antibody Formation; D009980:Influenza A virus / Q000276:immunology; D051379:Mice; D008807:Mice, Inbred BALB C / Q000276:immunology; D008819:Mice, Nude / Q000276:immunology*; D009976:Orthomyxoviridae Infections / Q000209:etiology / Q000276:immunology*; D013601:T-Lymphocytes / Q000276:immunology*