Hepatitis B antigens in serum and liver of chimpanzees acutely infected with hepatitis B virus.
We report the temporal patterns of various immunohistological and serological parameters of acute self-limited hepatitis B virus infection of two chimpanzees, and we provide evidence that the synthesis of hepatitis B core antigen precedes that of hepatitis B surface antigen. Our data suggest that existence of a biphasic hepatitis B virus infection involving a hematogenous reinfection of the liver and indicate that recruitment of liver cells to produce hepatitis B virus may occur in a pattern consistent with a replicative cycle of about 8 days.
D000410:Alanine Transaminase / Q000032:analysis; D000818:Animals; D001219:Aspartate Aminotransferases / Q000032:analysis; D002462:Cell Membrane / Q000276:immunology; D005455:Fluorescent Antibody Technique; D006168:Guinea Pigs / Q000276:immunology; D006509:Hepatitis B / Q000276:immunology*; D006511:Hepatitis B Antigens / Q000032:analysis*; D006515:Hepatitis B virus / Q000276:immunology*; D007106:Immune Sera; D007074:Immunoglobulin G; D008099:Liver / Q000276:immunology*; D008297:Male; D002679:Pan troglodytes; D011863:Radioimmunoassay
D006511:Hepatitis B Antigens; D007106:Immune Sera; D007074:Immunoglobulin G; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase