18-hydroxylated steroids in human hypertension - clinical study.
The detection of two unknown urinary steroids called x and y in various patients was previously reported. Compound x was tentatively characterized as a derivative of dihydro-18-hydroxy-DOC with two additional polar groups. In this communication clinical observations of a set of 25 hypertensive patients are presented. Compound x alone was found in 4 cases, compound y alone 4 cases and both compound x and y in 5 cases. In several other cases, hypokalemia and/or a decreased urinary Na+/K+ ratio were found.
D015070:18-Hydroxydesoxycorticosterone / Q000652:urine; D000293:Adolescent; D000328:Adult; D000368:Aged; D000450:Aldosterone / Q000097:blood / Q000652:urine; D005260:Female; D006801:Humans; D006900:Hydroxylation; D006973:Hypertension / Q000652:urine*; D008297:Male; D008875:Middle Aged; D013256:Steroids / Q000652:urine*
D015070:18-Hydroxydesoxycorticosterone; D013256:Steroids; D000450:Aldosterone