Mutations which affect amino acid transport in Aspergillus nidulans.
Mutants deficient in amino acid transport (aau), and unable to utilize L-glutamate as a sole carbon and nitrogen source, have been isolated. There are four unlinked genes involved: aauA, aauB, aauC and aauD. The transport levels of certain amino acids, and the growth characteristics on certain nitrogen and carbon sources and toxic amino acid analogues, indicate that: aauAI has defective transport of acidic amino acids; aauBI has defective transport of acidic and neutral amino acids; aauCI and aauDI have defective transport of acid, neutral and aromatic amino acids. aauAI and aauBI are recessive for all three characteristics in the heterozygous diploid; aauCI and aauDI are dominant.
D000409:Alanine / Q000378:metabolism; D000596:Amino Acids / Q000378:metabolism*; D001233:Aspergillus nidulans / Q000254:growth & development / Q000378:metabolism*; D001693:Biological Transport, Active; D050260:Carbohydrate Metabolism; D002250:Carbon Radioisotopes; D002874:Chromosome Mapping; D004171:Diploidy; D005796:Genes; D008040:Genetic Linkage; D005971:Glutamates / Q000378:metabolism; D006238:Haploidy; D009153:Mutagens; D009154:Mutation; D009566:Nitrates / Q000378:metabolism; D009604:Nitrosoguanidines; D010649:Phenylalanine / Q000378:metabolism; D000644:Quaternary Ammonium Compounds / Q000378:metabolism; D013237:Stereoisomerism; D013890:Thiourea / Q000378:metabolism
D000596:Amino Acids; D002250:Carbon Radioisotopes; D005971:Glutamates; D009153:Mutagens; D009566:Nitrates; D009604:Nitrosoguanidines; D000644:Quaternary Ammonium Compounds; D010649:Phenylalanine; D013890:Thiourea; D000409:Alanine