title: Antimalarial phenanthrene amino alcohols. 3. Halogen-containing 9-phenanthrenemethanols.
abstract: A series of new 9-phenanthrene amino alcohols has been prepared in which each compound bears from one to five halogen or halogen-containing moieties. A number of these compounds are extremely active against Plasmodium berghei in the mouse. Some structural requirements for optimal efficacy are considered.
mesh_terms: D000605:Amino Alcohols / Q000138:chemical synthesis / Q000627:therapeutic use; D000818:Animals; D000962:Antimalarials / Q000138:chemical synthesis* / Q000627:therapeutic use; D002645:Chickens; D006219:Halogens / Q000627:therapeutic use; D008288:Malaria / Q000188:drug therapy; D008289:Malaria, Avian / Q000188:drug therapy; D051379:Mice; D010616:Phenanthrenes / Q000138:chemical synthesis* / Q000627:therapeutic use; D010962:Plasmodium berghei; D013329:Structure-Activity Relationship
chemical_list: D000605:Amino Alcohols; D000962:Antimalarials; D006219:Halogens; D010616:Phenanthrenes