Lymphocytic infiltration of the brain in sleeping sickness.
Cerebrospinal fluid mononuclear cells from 40 patients with advanced Gambian sleeping sickness were examined for intracytoplasmic immunoglobulin and for B- and T-lymphocyte markers. About 5% of mononuclear cells were plasma cells. Most of the lymphocytes present were B cells. These findings suggest that the considerable lymphocytic infiltration of the nervous system seen in advanced sleeping sickness is not a cell-mediated immune reaction to trypanosomes. Immune complexes may play a part in producing the brain damage characteristic of this disease.
D001402:B-Lymphocytes; D002555:Cerebrospinal Fluid / Q000166:cytology; D006801:Humans; D007075:Immunoglobulin M / Q000134:cerebrospinal fluid; D010950:Plasma Cells / Q000648:ultrastructure; D013601:T-Lymphocytes; D014353:Trypanosomiasis, African / Q000134:cerebrospinal fluid*
D007075:Immunoglobulin M