[Intravital accumulation of acriflavine in mitochondria of yeast organisms].
Acriflavine, a fluorochrome of the acridine series, inducing cytoplasmic mutations in yeast organisms, at low concentrations (0.25 to 2.50 mcg/ml) in the growth medium, is selectively accumulated in the mitochondria in which it forms complexes with nucleic acids. This binding of acriflavine to nucleic acids in the mitochondria has almost no effect on the cell viability though their respiratory activity decreases at these concentrations by 70 percent, and the activity of fermentation increases by 15 to 20 percent.
D000166:Acridines / Q000378:metabolism*; D000167:Acriflavine / Q000378:metabolism* / Q000494:pharmacology; D001203:Ascomycota / Q000187:drug effects / Q000254:growth & development / Q000378:metabolism*; D002245:Carbon Dioxide / Q000378:metabolism; D003470:Culture Media; D008928:Mitochondria / Q000378:metabolism*; D003904:Mitosporic Fungi / Q000378:metabolism*; D010101:Oxygen Consumption; D012248:Rhodotorula / Q000187:drug effects / Q000254:growth & development / Q000378:metabolism*; D012441:Saccharomyces cerevisiae / Q000187:drug effects / Q000254:growth & development / Q000378:metabolism*
D000166:Acridines; D003470:Culture Media; D002245:Carbon Dioxide; D000167:Acriflavine
Prizhiznennoe nakoplenie akriflavina v mitokhondriiakh drozhzhevykh organiznov