Perturbations of humoral and cellular immunity in a patient with pigmented villonodular synovitis.
Several parameters of the immune system have been studied in a patient with pigmented villonodular synovitis. Numerous immunoglobulin-synthesizing cells were found by immunofluorescent technics in both synovium and synovial fluid. Phytohemagglutinin-induced in vitro blastogenesis of peripheral blood T lymphocytes was absent whereas B-lymphocyte blastogenesis was preserved. These results indicate a necessity for evaluating immune responsiveness in other patients with pigmented villonodular synovitis.
D000818:Animals; D000917:Antibody Formation; D001707:Biopsy, Needle; D002417:Cattle; D002648:Child; D003593:Cytoplasm / Q000648:ultrastructure; D005260:Female; D005455:Fluorescent Antibody Technique; D006801:Humans; D007109:Immunity; D007111:Immunity, Cellular; D007070:Immunoglobulin A; D007074:Immunoglobulin G; D007075:Immunoglobulin M; D007719:Knee Joint / Q000473:pathology; D037102:Lectins / Q000494:pharmacology; D008213:Lymphocyte Activation; D008214:Lymphocytes / Q000187:drug effects; D010950:Plasma Cells / Q000473:pathology; D011817:Rabbits / Q000276:immunology; D013582:Synovial Fluid / Q000166:cytology / Q000276:immunology; D013585:Synovitis / Q000276:immunology* / Q000473:pathology
D007070:Immunoglobulin A; D007074:Immunoglobulin G; D007075:Immunoglobulin M; D037102:Lectins