Genetic effects of providone-iodine.
Povidone-iodine is capable of specifically altering the DNA of living cells. This alteration may result in the induction of mutations of the base-substitution type. Because of the known relationship between mutagenic potential and the ability to induce cancer in animals, the present findings raise serious questions concerning the safety of this topical disinfectant.
D004254:DNA Nucleotidyltransferases / Q000037:antagonists & inhibitors; D004260:DNA Repair / Q000187:drug effects; D004269:DNA, Bacterial / Q000378:metabolism*; D004926:Escherichia coli / Q000201:enzymology; D009153:Mutagens / Q000494:pharmacology*; D011205:Povidone / Q000031:analogs & derivatives*; D011206:Povidone-Iodine / Q000494:pharmacology*; D012486:Salmonella typhimurium / Q000187:drug effects* / Q000378:metabolism; D013997:Time Factors
D004269:DNA, Bacterial; D009153:Mutagens; D011206:Povidone-Iodine; D004254:DNA Nucleotidyltransferases; D011205:Povidone