[Changes in the cytokinetics of Mott's cells following sensitization to BCG under conditions of preliminary treatment of rats with soluble antigens of Mycobacterium tuberculosis].
The effect of pretreatment with tuberculins on BCG sensitization of rats was expressed in the transformation of precursors into Mott's cells. The tuberculins, particularly the old tuberculin, inhibited the MC-reaction; this seems to be connected with the tolerogenic action of the mycobacterial polysaccharides. An attempt was made to interpret the results from the point of view of the three-component system of the lymphoid cell cooperation during the formation of humoral antibodies, taking into account the competitive antagonistic relations between the delayed hypersensitivity (DH) and the humoral immunity. It postulated that this competition is effectuated through the repression of the B cell function by the T1 lymphocyte killer effectors of the DH committed to the same antigen against which the "blasts" or the plasmoblasts (subsequently transformed into MC) were produced. The author believes the latter to be the cells in which specific antiboty synthesis was blocked in the statu nascendi due to ectopic (not in the Golgi zone, but in the cisterns of the rough reticulum) and an excessive complex assembly of polysaccharides with the peptide chains of immunoglobulins.
D000818:Animals; D000917:Antibody Formation; D001500:BCG Vaccine; D006968:Hypersensitivity, Delayed / Q000276:immunology; D007108:Immune Tolerance; D008198:Lymph Nodes / Q000276:immunology; D008297:Male; D008938:Mitosis; D010950:Plasma Cells / Q000276:immunology*; D051381:Rats; D013601:T-Lymphocytes / Q000276:immunology; D014373:Tuberculin; D014376:Tuberculosis / Q000276:immunology / Q000517:prevention & control*
D001500:BCG Vaccine; D014373:Tuberculin
Izmeneniia tsitokinetiki kletok Motta pri sensibilizatsii BTsZh v usloviiakh predvaritel'noĭ obrabotki krys rastvorimymi antigenami mikobakteriĭ tuberkuleza