title: [Distribution of chromosome breakage point induced by arabinosylcytosine on in-vitro human lymphocytes].
abstract: The cytogenetic effects of arabinosyl cytosine on human leukocytes in vitro has been studied using continuous and discontinuous treatments. Optimum activity occurs at the end of the S period. Interchromosomal distribution of breaks is non-random. The hypothesis of a very late replication for some chromatid segments is discussed. The relations between banding and the position of breaks are discussed.
mesh_terms: D002478:Cells, Cultured; D002842:Chromatids / Q000187:drug effects; D002869:Chromosome Aberrations; D002875:Chromosomes / Q000187:drug effects*; D003561:Cytarabine / Q000494:pharmacology*; D006801:Humans; D066298:In Vitro Techniques; D008214:Lymphocytes / Q000187:drug effects; D008938:Mitosis / Q000187:drug effects; D013997:Time Factors
chemical_list: D003561:Cytarabine
vernacular_title: Distribution des points de cassure chromosomique induits par l'arabinosyl cytosine sur des lymphocytes humains in vitro