[Influence of substances that change the serotonin level of the brain on the analgesic effect of promedol in rats].
In tests with determination of pain reaction in rats registered by their squeak and arising in reponse to a single electric irritation of the tail evidence was obtained to the effect that substances both lowering the serotonin content in the brain (p-chlorphenylalanine, reserpine) and raising it (5-oxytryptophan, pargilin) cause a fall of the threshold, viz. 5-oxytryptophan and pargilin display antagonism to the analgetic effect of trimeperidine hydrochloride, whereas p-chlorphenylalanine, and inhibitor of trypophan-hydroxylase and tipindol, an antagonist of serotonin, do not exert any noticeable influence on the extent of the analgesic effect of trimeperidine hydrochloride.
D006916:5-Hydroxytryptophan / Q000494:pharmacology*; D000698:Analgesia; D000818:Animals; D001921:Brain / Q000187:drug effects*; D004347:Drug Interactions; D008614:Meperidine / Q000494:pharmacology*; D010293:Pargyline / Q000494:pharmacology*; D010649:Phenylalanine / Q000494:pharmacology*; D051381:Rats; D012110:Reserpine / Q000494:pharmacology*; D012701:Serotonin / Q000378:metabolism*
D012701:Serotonin; D010649:Phenylalanine; D012110:Reserpine; D008614:Meperidine; D010293:Pargyline; D006916:5-Hydroxytryptophan
Vliianie veshchestv, izmeniaiushchikh soderzhanie serotonina v mozge, na anal'geticheskiĭ éffekt promedola u krys