Effect of cysteine on the hepatic toxicity and antischistosomal activity of antimonyl potassium tartrate.
Cysteine produced a significant and progressive reduction in the toxicity of antimonyl potassium tartrate (APT) when the two substances were injected into mice and rabbits in ratios of APT to cysteine ranging from 1:1 to 1:3. The reduction in toxicity was highest with the 1:3 ratio. However, the combination of the two substances, especially in the ratio of 1:3, appreciably reduced the antischistosomal activity of APT both in vivo and in vitro.
D000818:Animals; D000965:Antimony / Q000633:toxicity*; D000966:Antimony Potassium Tartrate / Q000627:therapeutic use / Q000633:toxicity*; D056486:Chemical and Drug Induced Liver Injury / Q000209:etiology*; D003545:Cysteine / Q000494:pharmacology*; D008099:Liver / Q000187:drug effects*; D008297:Male; D051379:Mice; D011817:Rabbits; D012552:Schistosomiasis / Q000188:drug therapy*
D000965:Antimony; D000966:Antimony Potassium Tartrate; D003545:Cysteine