DNA repair synthesis dependent on the uvrA,B gene products in toluene-treated cells.
Ultraviolet irradiation of toluene-treated Escherichia coli causes an inhibition of replicative DNA synthesis. This is followed by the appearance of nonconservative DNA repair synthesis which does not require either the polymerase or 5' leads to 3' exonucleolytic activities of DNA polymerase I. The repair synthesis may be catalyzed by DNA polymerase III activity but does not require a functional DNA polymerase II. The ultraviolet-induced synthesis requires ATP and is dependent on a functional uvrA and uvrB gene product. However, other uvr gene products are not required for the synthesis. The recB function is also not required.
D003227:Conjugation, Genetic; D004254:DNA Nucleotidyltransferases / Q000378:metabolism; D004260:DNA Repair / Q000187:drug effects*; D004261:DNA Replication / Q000187:drug effects* / Q000528:radiation effects; D004926:Escherichia coli / Q000187:drug effects / Q000378:metabolism*; D005796:Genes; D014050:Toluene / Q000494:pharmacology*; D014466:Ultraviolet Rays
D014050:Toluene; D004254:DNA Nucleotidyltransferases