[Multiple cartilaginous exostoses with polyposis of stomach and colon: a new, hereditary combination different from Gardner's syndrome (author's transl)].
Multiple cartilaginous exostoses were found in a 41-year-old man and his two sons, aged 11 and 15 years. The older boy had extensive polyposis of the sigmoid colon and gastric antrum, his brother had radiological changes suspicious of sigmoid polyposis, while there was no radiological evidence of polyposis in the father. None of them had any symptoms of polyposis. The described combination of findings suggests a separate entity from Gardner's syndrome, perhaps on the basis of a combined dominant gene inheritance. In case of multiple exostoses radiological and endoscopic examination of the gastro-intestinal tract for polyposis are indicated.
D000293:Adolescent; D000328:Adult; D002648:Child; D003110:Colonic Neoplasms / Q000150:complications* / Q000235:genetics; D005097:Exostoses, Multiple Hereditary / Q000150:complications* / Q000235:genetics; D006801:Humans; D007417:Intestinal Polyps / Q000150:complications* / Q000235:genetics; D008297:Male; D009378:Neoplasms, Multiple Primary / Q000150:complications; D010375:Pedigree; D011706:Pyloric Antrum; D012811:Sigmoid Neoplasms / Q000150:complications; D013274:Stomach Neoplasms / Q000150:complications* / Q000235:genetics; D013577:Syndrome
Multiple kartilaginäre Exostosen bei Kolon- und Magen-Polypose. Mitteilungen einer neuen, vom Gardner-Syndrom abweichenden erblichen Kombinationserkrankung