title: Acute mitral regurgitation from ruptured chordae tendineae in systemic lupus erythematosus.
abstract: A patient with systemic lupus erythematosus developed acute mitral regurgitation due to ruptured chordae tendineae, requiring mitral valve replacement. Typical changes of Libman-Sacks endocarditis were observed in the excised mitral valve. Immunofluorescent studies revealed antinuclear antibody and deposits of immunoglobulins and complement within small vessels.
mesh_terms: D000328:Adult; D000974:Antibodies, Antinuclear / Q000032:analysis; D002815:Chordae Tendineae / Q000473:pathology; D003165:Complement System Proteins / Q000032:analysis; D005260:Female; D006801:Humans; D007136:Immunoglobulins / Q000032:analysis; D008180:Lupus Erythematosus, Systemic / Q000150:complications* / Q000276:immunology; D008943:Mitral Valve / Q000276:immunology / Q000601:surgery; D008944:Mitral Valve Insufficiency / Q000209:etiology*; D012422:Rupture, Spontaneous
chemical_list: D000974:Antibodies, Antinuclear; D007136:Immunoglobulins; D003165:Complement System Proteins