[Cellular kinetics of the primary immune response after application of phytohemagglutinin].
The Jerne technique, a proved method for detecting the number of plaque-forming cells (PFC) in spleen, shows an immunosuppressive effect of phytohemagglutine (PHA) on primary immune response. Kinetic studies are done on 300 NMRI mice, considering the number of PFC/10-8 spleen cells. Significant suppressions of the primary immune response are found if PHA is applied either one day before or together with antigen provided that studies are done 3, 4 or 5 days after immunization with sheep red blood cells (SRBC). The role of activated T-lymphocytes concerning the diminution of immune response is discussed.
D000818:Animals; D000917:Antibody Formation / Q000187:drug effects*; D000921:Antibody-Producing Cells / Q000187:drug effects; D000937:Antigen-Antibody Reactions; D004912:Erythrocytes / Q000276:immunology; D006168:Guinea Pigs; D006462:Hemolytic Plaque Technique; D007075:Immunoglobulin M; D007165:Immunosuppression Therapy; D037102:Lectins / Q000494:pharmacology*; D008297:Male; D051379:Mice; D012756:Sheep / Q000276:immunology; D013154:Spleen / Q000276:immunology; D013997:Time Factors
D007075:Immunoglobulin M; D037102:Lectins
Zur zellulären Kinetik der primären Immunantwort nach Phytohämagglutiningabe