Effect of excision repair system on antibacterial and mutagenic activity of daunomycin and other intercalating agents in Salmonella typhimurium.
Daunomycin and adriamycin, are more mutagenic and antibacterial for a strain of Salmonella typhimurium defective for the uvrB gene than for its uvr+ counterpart. Other intercalating agents, as some acridine dyes, affect equally the two bacterial strains.
D000166:Acridines / Q000494:pharmacology*; D000900:Anti-Bacterial Agents; D003630:Daunorubicin / Q000494:pharmacology*; D004317:Doxorubicin / Q000494:pharmacology*; D009153:Mutagens; D011118:Polynucleotide Ligases / Q000378:metabolism*; D012486:Salmonella typhimurium / Q000187:drug effects*; D013329:Structure-Activity Relationship
D000166:Acridines; D000900:Anti-Bacterial Agents; D009153:Mutagens; D004317:Doxorubicin; D011118:Polynucleotide Ligases; D003630:Daunorubicin