title: Arthritogenicity of Mycobacterium smegmatis subfractions, related to different oil vehicle and different composition.
abstract: Arthrigenicity of Mycobacterium smegmatis subfractions appeared to be remarkably potentiated in oil vehicles such as squalane or mineral oil, while water-in-oil emulsions containing Arlacel A appeared to decrease or suppress their arthritogenicity. It seems that Arlacel A can exert a suppressive effect on the arthritogenicity of the subfractions. Poly I:C and acetylated wax D potentiated the arthritogenicity of lysozyme-solubilized product, while cord factor was unable to do so. When given together with either cell membrane fraction or cell envelope, the lysozyme-solubilized product produced much more severe disease than that of lysozyme-solubilized product alone. Cell walls lost much of their arthritogenicity when mixed with lysozyme-solubilized product.
mesh_terms: D000818:Animals; D001172:Arthritis, Rheumatoid / Q000276:immunology*; D004655:Emulsions; D005260:Female; D008899:Mineral Oil / Q000494:pharmacology*; D009113:Muramidase / Q000378:metabolism; D009161:Mycobacterium / Q000276:immunology*; D011070:Poly I-C / Q000494:pharmacology; D051381:Rats; D011917:Rats, Inbred Lew; D013185:Squalene / Q000494:pharmacology*; D013347:Subcellular Fractions / Q000276:immunology*; D014867:Water; D014885:Waxes / Q000494:pharmacology
chemical_list: D004655:Emulsions; D014885:Waxes; D014867:Water; D013185:Squalene; D008899:Mineral Oil; D009113:Muramidase; D011070:Poly I-C