title: Immunodeficiency and autoimmunity.
abstract: The following aspects of autoimmunity and immunodeficiency will be discussed: 1) Autoantibodies and autoimmunity and their relationships to human disease and particularly to the rheumatic diseases. 2) Relationships between human immunodeficiency diseases and autoimmunity including: a) autoimmune disease in patients with immunodeficiency; b) arthritis in patients with immunodeficiency; c) lupus-like illness in carriers of chronic granulomatous disease; d) occurrence of autoantibodies and autoimmunity in relatives of patients with immunodeficiency. 3) Immunodeficiency as a basis for human rheumatic or autoimmune diseases. The role of immunodeficiency in NZB mouse diseases and human SLE. 4) The role of viral infections in autoimmune disease.
mesh_terms: D000328:Adult; D000974:Antibodies, Antinuclear; D000936:Antigen-Antibody Complex; D001065:Appendix / Q000473:pathology; D001323:Autoantibodies; D001327:Autoimmune Diseases; D001770:Blood Bactericidal Activity; D003298:Coombs Test; D003384:Coxsackievirus Infections / Q000382:microbiology; D004770:Enterovirus / Q000302:isolation & purification; D005260:Female; D005921:Glomerulonephritis / Q000276:immunology; D006105:Granulomatous Disease, Chronic / Q000276:immunology; D006801:Humans; D007153:Immunologic Deficiency Syndromes; D007165:Immunosuppression Therapy; D007223:Infant; D008180:Lupus Erythematosus, Systemic / Q000276:immunology; D008198:Lymph Nodes / Q000473:pathology; D008213:Lymphocyte Activation; D008231:Lymphopenia / Q000276:immunology; D009130:Muscle, Smooth / Q000276:immunology; D009928:Organ Specificity; D012217:Rheumatoid Factor; D013045:Species Specificity; D013154:Spleen / Q000473:pathology; D013950:Thymus Gland / Q000002:abnormalities; D013961:Thyroid Gland / Q000276:immunology; D013966:Thyroiditis / Q000276:immunology
chemical_list: D000974:Antibodies, Antinuclear; D000936:Antigen-Antibody Complex; D001323:Autoantibodies; D012217:Rheumatoid Factor