Marked histoincompatibility between and within sublines of AKR mice used in a syngeneic leukemia model.
Sublines of AKR mice differed significantly in their histoincompatibility to AKR/J mice, as indicated by their ability to reject AKR/J skin grafts and an AKR transplantable leukemia. Further, all sublines tested demonstrated some degree of heterogeneity, because isografts were rejected in 5-97% of the mice, depending on the subline. The presence of excessive heterogeneity among and within sublines poses a serious problem for experimental oncologists using these sublines in their tumor models.
D000818:Animals; D006084:Graft Rejection; D006648:Histocompatibility; D007942:Leukemia, Experimental / Q000276:immunology*; D051379:Mice; D008806:Mice, Inbred AKR / Q000276:immunology*; D009368:Neoplasm Transplantation; D016038:Skin Transplantation; D014184:Transplantation, Homologous