Migration inhibition of peritoneal cells and PHA lymphocyte toxicity in rats during methylcholanthrene carcinogenesis.
Peritoneal exudate cells obtained from rats bearing primary methylcholanthrene-induced tumors were shown to be inhibited in their capillary tube migration capacity as compared to cells from nontreated control litter-mates. The survival of rat peripheral blood lymphocytes harvested from the same individuals were tested simultaneously in short-term cultures with a standard concentration of Phytohemagglutinin. Lymphocytes from tumor-bearing rats survived better than control lymphocytes in 24-hour cultures with Phytohemagglutinin. A correlation was found from a comparison of the results of these two methods. These findings are discussed with regard to the possibility of T cells depletion from peripheral lymphocyte population, together with the enrichment of this population with B cells in tumor-bearing individuals.
D000818:Animals; D001202:Ascitic Fluid / Q000166:cytology*; D001402:B-Lymphocytes / Q000276:immunology; D002464:Cell Migration Inhibition; D003601:Cytotoxicity Tests, Immunologic; D037102:Lectins; D008214:Lymphocytes / Q000276:immunology*; D008748:Methylcholanthrene; D009374:Neoplasms, Experimental / Q000139:chemically induced / Q000276:immunology*; D051381:Rats; D013601:T-Lymphocytes / Q000276:immunology
D037102:Lectins; D008748:Methylcholanthrene