The effect of central chemical sympathectomy on the oxygen uptake; anaerobic glycolysis and lactic acid dehydrogenase activity in the retina of white rats.
Male Wistar rats were injected intraventricularly with two doses of 250 mcg of 6-hydroxydopamine (6-OHDA) in two consecutive days. Two weeks later the oxygen uptake, anaerobic glycolysis and lactic acid dehydrogenase (LDH) activity in the retina were determined. The decrease of oxygen uptake (-28%), anaerobic glycolysis (-31%) and LDH activity (-12%) in rats treated with 6-OHDA in comparison to control animals was found. The possible role of the adrenergic system in regulation of the metabolism of the retina is discussed.
D000693:Anaerobiosis; D000818:Animals; D006019:Glycolysis / Q000187:drug effects*; D006892:Hydroxydopamines / Q000494:pharmacology*; D007770:L-Lactate Dehydrogenase / Q000378:metabolism*; D008297:Male; D010101:Oxygen Consumption / Q000187:drug effects*; D051381:Rats; D012160:Retina / Q000187:drug effects / Q000378:metabolism*; D013564:Sympathetic Nervous System / Q000187:drug effects*
D006892:Hydroxydopamines; D007770:L-Lactate Dehydrogenase