title: The regulation of arginine biosynthesis in Saccharomyces cerevisiae. The specificity of argR- mutations and the general control of amino-acid biosynthesis.
abstract: The regulation of arginine biosynthetic enzymes in yeast is subjected to a double control. One level of arginine enzyme synthesis is under the control of an apo-repressor, called ARGR. ARGR molecules control specifically the arginine pathway. A second level of control of arginine biosynthesis has been disclosed. It also controls tryptophan, histidine, lysine, isoleucine-valine and probably many more biosyntheses. The general mechanism is turned on in leaky mutants in any of the amino acid pathways mentioned above.
mesh_terms: D000596:Amino Acids / Q000096:biosynthesis*; D000641:Ammonia / Q000378:metabolism; D001120:Arginine / Q000096:biosynthesis*; D001123:Argininosuccinate Lyase / Q000378:metabolism; D005838:Genotype; D009154:Mutation; D009954:Ornithine Carbamoyltransferase / Q000378:metabolism; D012441:Saccharomyces cerevisiae / Q000378:metabolism*; D013045:Species Specificity
chemical_list: D000596:Amino Acids; D000641:Ammonia; D001120:Arginine; D009954:Ornithine Carbamoyltransferase; D001123:Argininosuccinate Lyase