[Selective concurrent suppression of the process of rosette-forming cell accumulation during the immune response].
Repeated injections to mice of normal rabbit immunoglobulins preceding immunization with sheep erythrocytes inhibited the accumulation of rosette-forming cells (RFC) in the spleen, without influencing the proliferation of the antibody-forming cells and hemaggutinin production. Reduction of the RFC under these conditions occurred on account of B-cells whose antigen-binding receptors could be blocked by antibodies against the aggregated mouse immunoglobulins and a complex of polyadenylic-polyuridylic acids. Repeated injections of the competitive antigen enhanced the formation of the immunological memory to the second antigen. The problem of the origin of the immune rosette-forming B-cells and their influence on the formation on the immunological memory is discussed.
D000818:Animals; D000888:Antibodies, Anti-Idiotypic; D000917:Antibody Formation; D000921:Antibody-Producing Cells / Q000276:immunology; D006388:Hemagglutinins / Q000096:biosynthesis; D007104:Immune Adherence Reaction; D007136:Immunoglobulins; D007156:Immunologic Memory; D051379:Mice; D008808:Mice, Inbred CBA; D011063:Poly A-U; D013154:Spleen / Q000276:immunology*; D013997:Time Factors
D000888:Antibodies, Anti-Idiotypic; D006388:Hemagglutinins; D007136:Immunoglobulins; D011063:Poly A-U
Izbiratel'noe konkurentnoe podavlenie protsessa nakopleniia rozetkoobrazuiushchikh kletok pri immunnom otvete