Functional half-life of virgin and primed B lymphocytes.
The functional half-life, a measure of the persistence of lymphocytes in an antigen-free environment, has been estimated and found to be about 7 days for virgin 2,4,6-trinitrophenyl (TNP)-reactive mouse B cells, and 2--3 times longer for TNP-primed B cells. Using allotype-congenic mice, lymph node cells were transferred from virgin or primed CBA/Igb donors to normal CBA/Iga recipients, and the proportion of donor B cells estimated at intervals...
D000818:Animals; D001402:B-Lymphocytes / Q000187:drug effects / Q000276:immunology*; D002470:Cell Survival; D005260:Female; D006207:Half-Life; D006241:Haptens; D007156:Immunologic Memory; D008297:Male; D051379:Mice; D008808:Mice, Inbred CBA; D014301:Trinitrobenzenes / Q000276:immunology; D014747:Vinblastine / Q000494:pharmacology
D006241:Haptens; D014301:Trinitrobenzenes; D014747:Vinblastine