Preliminary evidence for cell-mediated immunity in cross-protection among group A arboviruses.
Unfractionated and T cell-enriched populations from spleens of mice immunized with Sinbdis virus confer cross-protection against Semliki forest virus challenge in recipient mice. Both Group A viruses are serologically related, but not by tests for cross-neutralizing antibody. The protection in mice persisted for three consecutive cell passages in uninfected mice. The results suggest that cell-mediated immunity accounts for cross-protection.
D000818:Animals; D000914:Antibodies, Viral; D000956:Antigens, Viral; D001102:Arbovirus Infections / Q000517:prevention & control*; D003429:Cross Reactions; D007111:Immunity, Cellular; D007116:Immunization, Passive; D008214:Lymphocytes / Q000276:immunology; D051379:Mice; D012672:Semliki forest virus / Q000276:immunology*; D012845:Sindbis Virus / Q000276:immunology*; D013154:Spleen / Q000166:cytology; D013601:T-Lymphocytes / Q000276:immunology
D000914:Antibodies, Viral; D000956:Antigens, Viral