title: [Effects of short time extreme hemodilution with and without hypothermia on hemodynamic and biochemical parameters in the pig (author's transl)].
abstract: Extreme hemodilution as "Total Body Washout" (TBW) is a feasible method for the clinical therapy of endo- or exogenous intoxication. This method was modified for a simple and quick setup. Landrace pigs were hemodiluted with a special heart-lung-machine. Within 4 minutes the hematocrit was lowered to less than 1%. The rectal temperature fell hereby in a normothermic group (n = 15) to 35, 1 +/- 1, 1 degrees C and in a hypothermic one (n = 13) to 31,1 +/- 1,3 degrees C. The TBW was followed by a total exchange transfusion. Most of the parameters that were studied did not show significant differences between cold and warm perfusion. The proceeding was well tolerated by the animals, they were observed up to 6 weeks. Disadvantages of initial surface cooling may be avoided by extreme hemodilution with exclusive extracorporal cooling, when cardiac arrest in hypothermia is intended.
mesh_terms: D000818:Animals; D001794:Blood Pressure; D001810:Blood Volume; D001831:Body Temperature; D005078:Exchange Transfusion, Whole Blood; D005112:Extracorporeal Circulation / Q000009:adverse effects / Q000295:instrumentation / Q000379:methods*; D006323:Heart Arrest; D006400:Hematocrit; D006439:Hemodynamics; D007036:Hypothermia, Induced; D010477:Perfusion / Q000379:methods; D013552:Swine
vernacular_title: Auswirkungen kurzzeitiger extremer Hämodilution mit und ohne Hypothermie auf hämodynamische und biochemische Parameter an Schwein