Gastro-intestinal microbleeding under acetylsalicylic acid, ketoprofen and placebo.
A quantitative comparison of gastro-intestinal microbleeding induced by acetylsalicylic acid (ASA), 3.6 g daily, ketoprofen (KETO), 200 mg daily and placebo (P) was undertaken in 12 normal volunteers using a double-blind factorial design with repeated measures. We conclude that KETO induces less gastro-intestinal bleeding than ASA but more than placebo and that there is a significant residual bleeding under placebo following ASA.
D000893:Anti-Inflammatory Agents; D001241:Aspirin / Q000009:adverse effects*; D001577:Benzophenones / Q000009:adverse effects*; D006471:Gastrointestinal Hemorrhage / Q000139:chemically induced*; D006801:Humans; D007660:Ketoprofen / Q000009:adverse effects*; D008297:Male; D010919:Placebos
D000893:Anti-Inflammatory Agents; D001577:Benzophenones; D010919:Placebos; D007660:Ketoprofen; D001241:Aspirin