H-2 gene complex restricts transfer of delayed-type hypersensitivity in mice.
Sensitized lymphocytes can transfer a state of delayed-type hypersensitivity to soluble protein antigens to naive mice only if donor and recipient share the I-A region of the H-2 gene complex. Identity at the K or D region is not essential. The restriction is unlikely to result from ineffective homing of the injected cells or from their early destruction. It is thought to reflect a requirement for an Ir-gene controlled mechanism which governs effective interaction between sensitized T lymphocytes and antigen presented on the surface of macrophages.
D000818:Animals; D001402:B-Lymphocytes / Q000187:drug effects / Q000276:immunology; D003520:Cyclophosphamide / Q000494:pharmacology; D004139:Dinitrofluorobenzene / Q000494:pharmacology; D005260:Female; D005796:Genes; D006824:Hybridization, Genetic; D006968:Hypersensitivity, Delayed / Q000276:immunology*; D008198:Lymph Nodes / Q000187:drug effects / Q000276:immunology; D008214:Lymphocytes / Q000187:drug effects / Q000276:immunology; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains
D003520:Cyclophosphamide; D004139:Dinitrofluorobenzene