Detection of non-H2 antigen(s) which, like Ia antigens, are associated with the Fc receptor of B lymphocytes.
Antibodies contained in an A/J anti-B10 antiserum, when tested on lymphocytes from B10.A mice, were shown to bind to both B and T cells and to inhibit the binding of Ig complexes to the Fc receptors of B lymphocytes. These antibodies could be removed by absorption with B10.D2 lymphocytes. Similar results were obtained with lymphocytes from two to six (B6A)F1 x A/J backcross mice which had H-2a/a genotype. These data indicate that alloantigens determined by at least one non-H-2 locus are associated with or a part of Fc receptors. These antigens may be similar in structure and function to Ia antigens.
D000818:Animals; D001402:B-Lymphocytes / Q000276:immunology*; D001666:Binding Sites, Antibody; D002462:Cell Membrane / Q000276:immunology; D002874:Chromosome Mapping; D003433:Crosses, Genetic; D003601:Cytotoxicity Tests, Immunologic; D005260:Female; D005455:Fluorescent Antibody Technique; D008040:Genetic Linkage; D006649:Histocompatibility Antigens; D007141:Immunoglobulin Fc Fragments; D007518:Isoantibodies; D007519:Isoantigens; D008297:Male; D051379:Mice; D008805:Mice, Inbred A; D008810:Mice, Inbred C57BL; D013154:Spleen / Q000276:immunology
D006649:Histocompatibility Antigens; D007141:Immunoglobulin Fc Fragments; D007518:Isoantibodies; D007519:Isoantigens