title: Factors affecting filamentation in Candida albicans: changes in respiratory activity of Candida albicans during filamentation.
abstract: Glucose metabolism and respiration of Candida albicans were compared under conditions which permitted either maximal filamentous or maximal yeast growth. Changes in metabolism were monitored by comparing the quantities of ethanol produced, CO2 evolved, and oxygen consumed. Filamenting cultures produced more ethanol and less CO2 than yeasts, with oxygen consumption in the former concomitantly slower than that of the latter. Studies involving cofactors and inhibitors associated with electron transport imply that a transfer of electrons away from flavoprotein is required for maintenance of yeast morphology. Conditions consistent with a buildup of reduced flavoprotein, however, favored filament formation. These changes were expressed metabolically as a shift from an aerobic to a fermentative metabolism. The results presented are consistent with hypotheses correlating filament production with changes in carbohydrate metabolism and an interruption of electron transfer within the cell.
mesh_terms: D000166:Acridines / Q000494:pharmacology; D002176:Candida albicans / Q000378:metabolism*; D002245:Carbon Dioxide / Q000096:biosynthesis; D002250:Carbon Radioisotopes; D002701:Chloramphenicol / Q000494:pharmacology; D003847:Deoxyglucose / Q000494:pharmacology; D004579:Electron Transport; D000431:Ethanol / Q000096:biosynthesis; D005947:Glucose / Q000378:metabolism*; D007461:Iodoacetates / Q000494:pharmacology; D008928:Mitochondria / Q000187:drug effects; D010101:Oxygen Consumption; D011796:Quinacrine / Q000494:pharmacology
chemical_list: D000166:Acridines; D002250:Carbon Radioisotopes; D007461:Iodoacetates; D002245:Carbon Dioxide; D000431:Ethanol; D002701:Chloramphenicol; D003847:Deoxyglucose; D011796:Quinacrine; D005947:Glucose