Factors which influence development of macrophage-layer and spleen colonies in mice.
Irradiated mice infused with bone marrow cells developed colonies both in the spleen and on the macrophage layer of the cellulose acetate membrane which had been inserted into their peritoneal cavity. Factors influencing the ratio of spleen to macrophage-layer colonies were examined. The ratio of the colonies depended on the condition of the recipients rather than the condition of the injected cells provided there was no marked histoincompatibility between donors and recipients.
D000818:Animals; D001853:Bone Marrow / Q000528:radiation effects; D001854:Bone Marrow Cells; D016026:Bone Marrow Transplantation; D002369:Castration; D002452:Cell Count; D002455:Cell Division; D002999:Clone Cells; D005260:Female; D006648:Histocompatibility; D008264:Macrophages / Q000187:drug effects / Q000528:radiation effects; D008297:Male; D008567:Membranes, Artificial; D051379:Mice; D008815:Mice, Inbred Strains; D012737:Sex Factors; D013154:Spleen / Q000187:drug effects / Q000276:immunology* / Q000528:radiation effects; D013268:Stimulation, Chemical; D013936:Thymidine / Q000494:pharmacology; D014184:Transplantation, Homologous
D008567:Membranes, Artificial; D013936:Thymidine