title: Proteinase inhibitors in rheumatoid arthritis.
abstract: The concentrations of five normally occurring protease inhibitors in serum and synovial fluid were compared in patients with rheumatoid arthritis, osteoarthrosis, and normal controls. The patients with rheumatoid arthritis showed a significant rise in alpha1-antitrypsin, alpha1-antichymotrypsin, and inter-alpha-trypsin inhibitor (in decreasing order) in serum as well as in synovial fluid. In synovial fluid the inhibitors were present in their native form and bound to hyaluronate. A large molecular protein with immunological specificity of alpha1-antitrypsin, presumably a complex of alpha1-antitrypsin and a protease, could be shown in synovial fluid of all patients with classical and probable rheumatoid arthritis and not in that of the other subjects studied.23Author
mesh_terms: D001172:Arthritis, Rheumatoid / Q000201:enzymology*; D002850:Chromatography, Gel; D002918:Chymotrypsin / Q000037:antagonists & inhibitors / Q000097:blood; D005260:Female; D006801:Humans; D006821:Hyaluronoglucosaminidase; D007122:Immunoelectrophoresis; D008297:Male; D008970:Molecular Weight; D010003:Osteoarthritis / Q000201:enzymology; D011480:Protease Inhibitors; D013582:Synovial Fluid / Q000201:enzymology; D014361:Trypsin Inhibitors / Q000032:analysis / Q000097:blood; D000515:alpha 1-Antitrypsin / Q000032:analysis / Q000097:blood
chemical_list: D011480:Protease Inhibitors; D014361:Trypsin Inhibitors; D000515:alpha 1-Antitrypsin; D006821:Hyaluronoglucosaminidase; D002918:Chymotrypsin