Alpha1-antitrypsin deficiency and pancreatic fibrosis.
A 39-year-old woman with homozygous ZZ alpha1-antitrypsin deficiency was found to have pancreatic fibrosis in addition to the recognized pulmonary and hepatic abnormalities. Pancreatic exocrine function was normal but endocrine studies showed glucose intolerance. Pancreatic fibrosis may be another manifestation of alpha1-antitrypsin deficiency.
D000328:Adult; D005260:Female; D005951:Glucose Tolerance Test; D006720:Homozygote; D006801:Humans; D007328:Insulin / Q000378:metabolism; D000078790:Insulin Secretion; D008099:Liver / Q000473:pathology / Q000648:ultrastructure; D008103:Liver Cirrhosis / Q000235:genetics / Q000473:pathology; D010179:Pancreas / Q000473:pathology / Q000503:physiopathology; D010182:Pancreatic Diseases / Q000235:genetics* / Q000473:pathology / Q000503:physiopathology; D010189:Pancreatic Juice / Q000378:metabolism; D011656:Pulmonary Emphysema / Q000235:genetics / Q000473:pathology / Q000503:physiopathology; D019896:alpha 1-Antitrypsin Deficiency
D007328:Insulin