title: RNA and protein synthesis in spontaneous rosette formation by T lymphocytes.
abstract: Formation of rosettes with sheep red blood cells (SRBC) by peripheral blood lymphocytes and thymocytes has been studied. Trypsinization of these cells abolishes the capacity to form SRBC-rosettes. The process of re-establishment of this capacity to form SRBC-rosettes, in vitro, has been shown by use of metabolic inhibitors to require transcription, translation, and protein synthesis. These observations are interpreted in terms of the T cell markers as the expression of a definitive process or step in lymphoid cell differentiation.
mesh_terms: D000546:Amanitins; D000818:Animals; D001773:Blood Cells; D001798:Blood Proteins / Q000096:biosynthesis*; D002454:Cell Differentiation; D002470:Cell Survival; D003609:Dactinomycin; D004912:Erythrocytes / Q000276:immunology; D006801:Humans; D007104:Immune Adherence Reaction; D014176:Protein Biosynthesis; D011691:Puromycin; D012313:RNA / Q000096:biosynthesis*; D012756:Sheep / Q000276:immunology; D013601:T-Lymphocytes / Q000276:immunology*; D013950:Thymus Gland / Q000166:cytology; D014158:Transcription, Genetic; D014357:Trypsin
chemical_list: D000546:Amanitins; D001798:Blood Proteins; D003609:Dactinomycin; D011691:Puromycin; D012313:RNA; D014357:Trypsin