Effect of the antiepileptic drug sodium valproate on induction of hepatic microsomal P450.
Sodium valproate is an anticonvulsant which, unlike phenobarbitone, does not produce an increase in rat hepatic P450 when given in large nontherapeutic doses.
D000818:Animals; D000927:Anticonvulsants / Q000494:pharmacology*; D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism*; D004790:Enzyme Induction / Q000187:drug effects; D008297:Male; D008862:Microsomes, Liver / Q000201:enzymology*; D010634:Phenobarbital / Q000494:pharmacology; D011189:Potassium Chloride / Q000494:pharmacology; D051381:Rats; D014631:Valerates / Q000494:pharmacology*; D014635:Valproic Acid / Q000494:pharmacology*
D000927:Anticonvulsants; D014631:Valerates; D014635:Valproic Acid; D011189:Potassium Chloride; D003577:Cytochrome P-450 Enzyme System; D010634:Phenobarbital