The inter-relationship of antigenic structure, thymus-independence and adjuvanticity. IV. A general model for B-cell induction.
Polymerized flagellin and E. coli lipopolysaccharide both express adjuvanticity in vivo and in vitro for responses to hapten conjugated to sheep erythrocytes, and hapten conjugated to soluble thymus-dependent antigens. In the case of erythrocyte-bound hapten, adjuvanticity is expressed in the absence of thymus-derived cells (T cells). However, in the case of responses to soluble thymus-dependent conjugates, carrier-specific T cells would appear to be necessary for adjuvanticity to be expressed. On the basis of these observations an hypothesis for the mechanism of B-cell induction and tolerance is proposed.
D000276:Adjuvants, Immunologic; D000818:Animals; D000918:Antibody Specificity; D000937:Antigen-Antibody Reactions; D000942:Antigens, Bacterial; D001402:B-Lymphocytes / Q000276:immunology*; D002352:Carrier Proteins; D004912:Erythrocytes / Q000276:immunology; D004926:Escherichia coli / Q000276:immunology; D005407:Flagella / Q000276:immunology; D006241:Haptens; D051379:Mice; D008954:Models, Biological; D011817:Rabbits; D012756:Sheep / Q000276:immunology; D012995:Solubility; D013601:T-Lymphocytes / Q000276:immunology
D000276:Adjuvants, Immunologic; D000942:Antigens, Bacterial; D002352:Carrier Proteins; D006241:Haptens