Immune reactivity in renal cancer: a sequential study.
We evaluated 18 patients with adenocarcinoma of the kidney immunologically in a linear fashion. Delayed cutaneous hypersensitivity was significantly altered in patients with metastatic disease. In vitro studies have shown a progressive decline in the absolute number of circulating lymphocytes and the T cell subpopulations that parallels the advance of the maligant process. Evaluation of lymphocyte function by the response to mitogens appears to be of little significance in a sequential study.
D000230:Adenocarcinoma / Q000276:immunology*; D001402:B-Lymphocytes / Q000276:immunology; D004137:Dinitrochlorobenzene / Q000276:immunology; D006801:Humans; D006968:Hypersensitivity, Delayed / Q000276:immunology; D007680:Kidney Neoplasms / Q000276:immunology*; D008213:Lymphocyte Activation; D008934:Mitogens; D013601:T-Lymphocytes / Q000276:immunology
D004137:Dinitrochlorobenzene; D008934:Mitogens