[Clinical studies on the effect of drugs used in the treatment of angina].
The report is based on a four-centre study on 25 patients with coronary insufficiency (ECG signs). In random sequence the following were given to each patient: a nitrate (isosorbide dinitrate), carbocromene, practolol, and oxyphedrine. The initial criterion for inclusion was S-T depression of 0.2 mV on stepwise exercise (bicycle ergometry). S-T depression, systolic blood pressure and heart rate changes were used as criteria. For each drug there was an acute test and a long-term test of 12 days. The Friedman test was used for the statistical evaluation of the results. Isosorbide dinitrate decreased the extent of S-T depression in the acute tests while practolol did so in the long-term test. Practolol reduced systolic pressure on long-term administration, with no difference in the acute experiment. Heart rate was reduced by practolol both acutely and long-term. These results give no indication for any possible differential treatment of coronary insufficiency, but this may be due to the selection of patients in this study.
D000328:Adult; D000368:Aged; D000605:Amino Alcohols / Q000627:therapeutic use; D000787:Angina Pectoris / Q000188:drug therapy* / Q000503:physiopathology; D001794:Blood Pressure / Q000187:drug effects; D002986:Clinical Trials as Topic; D003374:Coumarins / Q000627:therapeutic use*; D005069:Evaluation Studies as Topic; D005260:Female; D006016:Glycolates / Q000627:therapeutic use*; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D007548:Isosorbide Dinitrate / Q000494:pharmacology / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D010627:Phenethylamines / Q000627:therapeutic use; D011217:Practolol / Q000494:pharmacology / Q000627:therapeutic use*; D011427:Propiophenones / Q000627:therapeutic use*; D011674:Pulse / Q000187:drug effects
D000605:Amino Alcohols; D003374:Coumarins; D006016:Glycolates; D010627:Phenethylamines; D011427:Propiophenones; D007548:Isosorbide Dinitrate; D011217:Practolol
Klinische Vergleichsstudie über den Effekt der vier koronarwirksamen Hauptsubstanzgruppen