Rickets in Nigerian children--response to vitamin D.
The findings in 20 cases of nutritional rickets treated on an out-patient basis with oral calciferol and calcium gluconate are reported. Attention was paid to their clinical, biochemical and radiological responses. If was noted that presentation at the hospital out-patient department was always delayed until there were obvious and sometimes severe deformities in  the children. Biochemical changes noted during the early phase of treatment showed an initial fall in the level of serum calcium and plasma phosohorus and a rise in the serum alkaline phosphatase. About three months after initiating treatment, calcium and phosphorus reverted to normal levels but serum alkaline phosphatase still remained high. Twelve of our cases (60 per cent) suffered from protein calorie malnutrition of the marasmic type and showed an apparent resistance to vitamin D therapy in what may be regarded as normal dosages. Response was however, achieved with substantial increase in the amount of vitamin given. There was a striking sex difference in the ratio of 15 males to five females indicating that males are more likely to develop nutritional rickets than females when subjected to predisposing environmental conditions. Vitamin D resistant type of rickets was not encountered in this study.
D000469:Alkaline Phosphatase / Q000097:blood; D002118:Calcium / Q000097:blood / Q000627:therapeutic use; D002648:Child; D002675:Child, Preschool; D004872:Ergocalciferols / Q000627:therapeutic use*; D005260:Female; D005942:Gluconates / Q000627:therapeutic use; D006801:Humans; D007223:Infant; D008297:Male; D009549:Nigeria; D010758:Phosphorus / Q000097:blood; D012279:Rickets / Q000097:blood / Q000188:drug therapy* / Q000201:enzymology / Q000453:epidemiology
D004872:Ergocalciferols; D005942:Gluconates; D010758:Phosphorus; D000469:Alkaline Phosphatase; D002118:Calcium