[Postpartum hemorrhage syndrome caused by factor VIII inhibitor in the blood].
The appearance of Factor VIII inhibitor in women after childbirth is a very rare occurence. However the hemorrhagic syndrome which results from such condition can be very serious and difficult to treat. In this paper a case of young women is described who developed after childbirth a severe bleeding disorder. Clinical feature was very similar to those seen in haemophilia. The patient was investigated in the local hospital but the diagnosis was not made. The bleeding disorder lasted with various extension for six months and patient finally developed a severe sublingual and laringeal bleeding. She was transfered to the Clinic "B" of Internal Medicine in a very serious condition. On examination there was marked prolongation of the clotting time and no detectable Factor VIII. On the basis of these findings and the clinical expression of bleeding disorders, the tentative diagnosis of Factor VIII inhibitor was made. The treatment was not possible to institute because the patient expired within hours. Autopsy showed that bleeding into deep laringeal tissue was the sole cause of her death. Additional examination of the of the patient's plasma specimen using the antibody assay (Biggs-Bidwell-1959) showed the presence of the antibody to the Factor Viii which were active in 1:100 dilution.
D000328:Adult; D001778:Blood Coagulation Disorders / Q000150:complications* / Q000473:pathology; D005169:Factor VIII / Q000037:antagonists & inhibitors*; D005260:Female; D006801:Humans; D006473:Postpartum Hemorrhage / Q000209:etiology* / Q000473:pathology; D011247:Pregnancy; D013577:Syndrome; D013997:Time Factors
D005169:Factor VIII
Postpartalni hemoragijski sindrom prouzrokovan inhibitorom VIII faktora koagulacije krvi