title: Influence of various anesthetic drugs on the intraocular pressure of cats.
abstract: Cats with one normal eye and one eye with experimental glaucoma were trained to tolerate tonometry while conscious. They were then given the general anesthetic agents pentobarbital, ketamine, and CI-744 in the lowest and twice the lowest dosages which permitted tonometry in untrained cats. Pentobarbital lowered intraocular pressure (IOP) by 20-50%. Ketamine raised IOP by about 10%. CI-744 had essentially no effect on IOP. The two conpoments of CI-744, tiletamine (CI-634) and zolazepam (CI-716) were given individually in the doses in which they had been given as part of CI-744. Tiletamine had no effect on IOP, while zolazepam lowered IOP by about 10%.
mesh_terms: D000777:Anesthetics / Q000494:pharmacology*; D000818:Animals; D001381:Azepines / Q000494:pharmacology; D002415:Cats; D004338:Drug Combinations; D005260:Female; D005901:Glaucoma; D007429:Intraocular Pressure / Q000187:drug effects*; D007649:Ketamine / Q000494:pharmacology; D008297:Male; D010424:Pentobarbital / Q000494:pharmacology; D013992:Tiletamine / Q000494:pharmacology; D014065:Tonometry, Ocular
chemical_list: D000777:Anesthetics; D001381:Azepines; D004338:Drug Combinations; D013992:Tiletamine; D007649:Ketamine; D010424:Pentobarbital