Thymus dependence of rabies vaccine.
Immune responses to rabies vaccine were compared with those to known thymus-dependent and thymus-independent antigens, in nude mice and their normal litter mates. No antibody response to, or protection against, challenge was observed in nude mice inoculated with either 1 or 2 doses of rabies vaccine. A single dose of the same vaccine induced a substantial antibody response and protected normal mice. These data indicate that the antigens in rabies vaccine that induce neutralizing antibody and protect mice are thymus-dependent.
D000818:Animals; D000914:Antibodies, Viral; D000917:Antibody Formation; D051379:Mice; D008819:Mice, Nude; D009500:Neutralization Tests; D011819:Rabies Vaccines; D011820:Rabies virus / Q000276:immunology; D013601:T-Lymphocytes / Q000276:immunology*
D000914:Antibodies, Viral; D011819:Rabies Vaccines