[Mathematical analysis of the n-cholinolytic effects in experiments with the isolated frog rectus abdominis muscle].
An inquiry into the nature of antagonism of alpha-tubocurarine and gentamycin to acetylcholine based on a mathematical analysis of cumulative curves obtained in experiments with an isolated musculus rectus abdominalis of the frog showed that the character of changes in the parameters of cumulative curves occuring under the effect of alpha-tubocurarine cannot be explained from the standpoint of Clark's (1929) "employment theory", but accords with deductions drawn from a more general theory of allosteric interaction of substances and receptors (Karlin--1967) in competitive antagonism. Variations in the parameters of cumulation curves occurring under the action of gentamycin may be regarded as a manifestation of non-competative to acetylcholine in conformity with both theories.
D000109:Acetylcholine / Q000494:pharmacology; D000818:Animals; D004305:Dose-Response Relationship, Drug; D004347:Drug Interactions; D005839:Gentamicins / Q000494:pharmacology; D066298:In Vitro Techniques; D008297:Male; D008433:Mathematics; D008954:Models, Biological; D008956:Models, Chemical; D009119:Muscle Contraction / Q000187:drug effects; D009132:Muscles / Q000187:drug effects*; D010276:Parasympatholytics / Q000494:pharmacology*; D011896:Rana temporaria; D014403:Tubocurarine / Q000494:pharmacology
D005839:Gentamicins; D010276:Parasympatholytics; D000109:Acetylcholine; D014403:Tubocurarine
O matematicheskoĭ analize n-kholinoliticheskikh ĕffektov v opytakh s izolirovannoĭ priamoĭ myshtseĭ zhivota liagushki