The humoral response of mouse spleen cells to two types of sheep erythrocytes. II. Evidence for gene expression in the B lymphocyte.
There is multigene control of the response of mouse spleen cells to two types of sheep erytrocytes (H and L). Discriminator strains of mice make a much higher response to extra antigens found only on H SRBC than to the shared antigens found on both types of erythrocyte. Non-discriminator strains respond only to the shared antigens, making a responses as great as the discriminator response to the extra antigens. The cell type in which this genetic control is expressed was investigated by a number of methods for studying the role of the macrophage, T cell, and B cell in the production of anti-SRBC response. The results provide no evidence that the gene(s) operate at the macrophage, T cell, or any other accessory cell level. The data from B cell-limiting dilution experiments are compatible with genetic expression at the B cell level.
D000818:Animals; D001402:B-Lymphocytes / Q000276:immunology*; D002448:Cell Adhesion; D003165:Complement System Proteins; D004912:Erythrocytes / Q000276:immunology*; D005796:Genes; D007106:Immune Sera / Q000302:isolation & purification; D007109:Immunity; D066298:In Vitro Techniques; D008264:Macrophages / Q000276:immunology; D051379:Mice; D008810:Mice, Inbred C57BL; D008811:Mice, Inbred DBA; D012756:Sheep / Q000276:immunology*; D013154:Spleen / Q000276:immunology*; D013601:T-Lymphocytes / Q000276:immunology
D007106:Immune Sera; D003165:Complement System Proteins