title: Hyaline membrane disease treated with early nasal end-expiratory pressure: one year's experience.
abstract: This report describes one year's experience treating hyaline membrane disease (HMD) with nasal end-expiratory pressure (NEEP). During the 12 months from July 1, 1973 through June 30, 1974, 119 children with HMD were admitted to the Intensive Care Unit of St. Paul Children's Hospital. Sixty-nine infants were treated early in the course of their disease with NEEP. The survival, incidence of complications, and the number of endotracheal intubations are reported and compared to our experience during a similar time period prior to the use of NEEP (1971-1972). Since the advent of the early application of modest amounts of end-expiratory pressure by nasopharyngeal tube, there has been an increase in the survival of all admissions with HMD, but the increase was statistically significant (P less than .01) only in those weighing 1,501 to 2,000 gm. There was a significant decrease (P less than .025) in the total number of children with HMD requiring endotracheal intubation. There was no change in the incidence of pneumothoraces or bronchopulmonary dysplasia. NEEP is a simple and effective technique for creating continuous airway distending pressure. Its effectiveness and ready availability make the routine endotracheal intubation of infants requiring only continuous airway distending pressure no longer justifiable.
mesh_terms: D001784:Blood Gas Analysis; D006801:Humans; D006819:Hyaline Membrane Disease / Q000000981:diagnostic imaging / Q000503:physiopathology / Q000628:therapy*; D007231:Infant, Newborn; D007232:Infant, Newborn, Diseases / Q000628:therapy*; D007442:Intubation, Intratracheal; D009296:Nasal Cavity / Q000503:physiopathology*; D009666:Nose / Q000503:physiopathology*; D011175:Positive-Pressure Respiration / Q000379:methods*; D011859:Radiography; D012127:Respiratory Distress Syndrome, Newborn / Q000175:diagnosis; D012122:Ventilators, Mechanical