Correlation of serum creatinine concentration and amikacin half-life.
The half-life of amikacin in serum has been measured following the administration of a single intravenous injection of 7 mg/kg in nine adult patients with varying degrees of renal function impairment and in four patients with normal renal function. A linear relationship between the half-life and the serum concentration has been found, suggesting that half-life of amikacin in serum can be calculated by multiplying the serum creatinine (in mg/100 ml) by 3.
D000328:Adult; D000583:Amikacin / Q000097:blood; D002986:Clinical Trials as Topic; D003404:Creatinine / Q000097:blood*; D006207:Half-Life; D006801:Humans; D007612:Kanamycin / Q000031:analogs & derivatives*; D007674:Kidney Diseases / Q000378:metabolism
D007612:Kanamycin; D000583:Amikacin; D003404:Creatinine