[Collagenous fibrillogenesis in the damaged arterial intima].
Development of fibromuscular hyperplasia of the intima (intimal thickening) as a characteristic reparative reaction of the intimal tissue was found in the carotid artery and abdominal aorta after an increased mechanical loading during experimental stenosis by means of optical and electronic microscopic examinations of the arterial wall. In children, whose death was caused by rheumatism at various phases of the disease in the coronary artery there was also focal diffuse intimal hyperplasia. Both in the experimental and in the rheumatic injuries of the arteries in the thickened intima there was more scarce infiltration with plasmatic proteins and lipids were discovered. An inference was made for interferention of serum insudation with collagenous synthesis in the damaged and reparative thickening of the arterial intima.
D000293:Adolescent; D000818:Animals; D001012:Aorta, Abdominal / Q000293:injuries / Q000502:physiology; D001158:Arteries / Q000293:injuries / Q000502:physiology*; D002339:Carotid Arteries / Q000502:physiology; D020212:Carotid Artery Injuries; D002648:Child; D002675:Child, Preschool; D003094:Collagen / Q000096:biosynthesis*; D003331:Coronary Vessels / Q000503:physiopathology; D005260:Female; D006801:Humans; D008026:Ligation; D008297:Male; D051381:Rats; D012038:Regeneration; D012216:Rheumatic Diseases / Q000503:physiopathology; D013997:Time Factors
D003094:Collagen
Vurkhu kolagennata fibrilogeneza v uvredenata arterialna intima