Effect of cycloheximide on pregnenolone-16alpha-carbonitrile (PCN)-induced ultrastructural changes in the rat liver.
Cycloheximide (10 mg/100 g body weight i.v. twice), an inhibitor of protein synthesis, caused smooth endoplasmic reticulum (SER) accumulation in the hepatocytes of female rats. Pregnenolone-16alpha-carbonitrile (PCN), given p.o., had a similar effect. When cycloheximide was administered to PCN-treated rats, SER proliferation as well as myelin figure formation were noted.
D000818:Animals; D003513:Cycloheximide / Q000008:administration & dosage / Q000494:pharmacology*; D004721:Endoplasmic Reticulum / Q000187:drug effects*; D005260:Female; D050356:Lipid Metabolism; D008099:Liver / Q000187:drug effects* / Q000648:ultrastructure; D008938:Mitosis / Q000187:drug effects; D011285:Pregnenolone Carbonitrile / Q000008:administration & dosage / Q000494:pharmacology*; D011292:Premedication; D051381:Rats; D014158:Transcription, Genetic / Q000187:drug effects
D011285:Pregnenolone Carbonitrile; D003513:Cycloheximide