[Recent data on the immunology of tumors. Mechanisms of escape of immunological control. Role of suppressor cells].
Cells in spleens from tumor bearing animals were found to inhibit in vitro reactivity of lymphocytes to a variety of stimulants. These suppressor cells inhibited the stimulation of normal lymphocytes by mitogens : P.H.A.-Con A-L.P.S. They were adherent cells, bore immunoglobulins at their surface and did not bear the 0 marker. They were also demonstrated in T deprived tumor bearing animals. They might be B cells, or, more probably, macrophages. Other activities that are inhibited by the suppressor cells are: -reactivity to allogenic cells in the mixed lymphocyte culture, -in vitro generation of secondary anti tumor cytotoxic effector cells, -macrophage migration inhibition in the presence of immune lymphocytes and tumor extracts, -reactivity against syngeneic tumor cells or tumor extracts. Suppressor cells may play a role in the general immunodepression of tumor bearing hosts, and in the inability of tumor bearing hosts to reject the tumor. However, the biological role of these non T suppressor cells is not clear, as they also inhibit tumor cell growth, and in vivo experiments favour suppressor cells of thymic origin.
D000818:Animals; D001402:B-Lymphocytes / Q000276:immunology*; D002464:Cell Migration Inhibition; D003208:Concanavalin A / Q000494:pharmacology; D005354:Fibrosarcoma / Q000276:immunology*; D066298:In Vitro Techniques; D037102:Lectins / Q000276:immunology; D008070:Lipopolysaccharides / Q000494:pharmacology; D008213:Lymphocyte Activation; D008264:Macrophages / Q000276:immunology*; D051379:Mice; D009368:Neoplasm Transplantation; D009374:Neoplasms, Experimental / Q000276:immunology; D009858:Oncogenic Viruses
D037102:Lectins; D008070:Lipopolysaccharides; D003208:Concanavalin A
Données récentes sur l'immunologie des tumeurs, Mécanismes d'échappement au contrôle immunologique. Rôle des cellules suppressives