Electrophoresis of lymphoid cells. A study of Bruton type of agammaglobulinaemia, thymic dysplasia, chronic lymphatic leukaemia and of normal human thymocytes.
The mean electrophoretic mobility (EPM) of blood lymphocytes from a patient with Bruton type of agammaglobulinaemia was high with a unimodal distribution pattern. That of blood lymphocytes from a patient with severe thymic dysplasia was low, with a small faster group. The difference between the major groups was about 30%. Thymocytes had a mean EPM 25% lower than that of normal T cells. Blood and spleen cells in a chronic lymphatic leukaemic of B-cell origin had a mean EPM 35% higher than that of the majority of normal B cells.
D000361:Agammaglobulinemia / Q000503:physiopathology*; D001402:B-Lymphocytes / Q000502:physiology; D002648:Child; D004586:Electrophoresis; D006801:Humans; D007153:Immunologic Deficiency Syndromes / Q000503:physiopathology; D066298:In Vitro Techniques; D007223:Infant; D007945:Leukemia, Lymphoid / Q000503:physiopathology*; D008297:Male; D013154:Spleen / Q000166:cytology; D013499:Surface Properties; D013601:T-Lymphocytes / Q000502:physiology*; D013950:Thymus Gland / Q000002:abnormalities*