Immunologic studies of male infertility.
Infertile men with azo- or oligospermia of unknown cause were investigated for evidence of testicular autoimmunity. Testicular germinal cell antibodies were found in 14% of the patients, compared with 5% of normal men, and 21% had spermatozoal antibodies, compared with 5% of the normal subjects. One-third had positive macrophage inhibitory factor tests, compared with 5% of normal subjects. However, of autoantibodies against thyroid, stomach, and nuclear material, only the prevalence of thyroid cytoplasmic antibodies was significantly greater than in normal subjects; serum IgG, IgM, and IgA levels were normal in all cases tested. Furthermore, there was no excess of lymphoid tissue on biopsy and no evidence of antibody deposition in the testicular tissue. The evidence for autoimmunity is less impressive than that for leprous orchitis, which has been proposed as a model for testicular organ-specific autoimmunity. Nevertheless, it is possible that certain germinal cell or spermatozoal antibodies may be directed against factors necessary for orderly spermatogenesis. If so, they may play a role in some cases of maturation arrest and shedding defects.
D000328:Adult; D000906:Antibodies / Q000302:isolation & purification*; D001323:Autoantibodies / Q000302:isolation & purification; D005260:Female; D006801:Humans; D007246:Infertility / Q000276:immunology*; D008213:Lymphocyte Activation; D008263:Macrophage Migration-Inhibitory Factors / Q000302:isolation & purification; D008264:Macrophages / Q000276:immunology; D008297:Male; D008875:Middle Aged; D009845:Oligospermia / Q000276:immunology*; D013091:Spermatogenesis; D013094:Spermatozoa / Q000276:immunology; D013737:Testis / Q000276:immunology / Q000473:pathology
D000906:Antibodies; D001323:Autoantibodies; D008263:Macrophage Migration-Inhibitory Factors