title: Cellular recognition and activation within the lymphoid system.
abstract: The present study is concerned with cellular recognition and activation within the lymphoid system. Data presented indicate that in human peripheral blood phagocytes recognize and preferentially bind phagocytes, and thymus-derived (T) lymphocytes recognize and preferentially bind other T lymphocytes rather than thymus-indepedent (B) lymphocytes. Recognition of non-self results in activation of lymphoid cells; recent data using a calcium ionophore, A23 187, suggest that calcium may act as an intracellular messenger by which signals for cellular activation are transmitted from the cell surface to the nucleus.
mesh_terms: D000818:Animals; D001402:B-Lymphocytes / Q000276:immunology / Q000378:metabolism; D001665:Binding Sites; D001773:Blood Cells / Q000276:immunology*; D002118:Calcium / Q000502:physiology; D002417:Cattle; D002462:Cell Membrane / Q000276:immunology; D004912:Erythrocytes / Q000378:metabolism; D006801:Humans; D007104:Immune Adherence Reaction; D007111:Immunity, Cellular; D008221:Lymphoid Tissue / Q000276:immunology*; D010586:Phagocytes / Q000276:immunology / Q000378:metabolism; D010587:Phagocytosis; D010802:Phylogeny; D012756:Sheep; D013601:T-Lymphocytes / Q000276:immunology / Q000378:metabolism
chemical_list: D002118:Calcium