title: Depression and anxiety in heroin addicts: a placebo-controlled study of doxepin in combination with methadone.
abstract: Narcotic addicts may manifest symptoms of depression that aggravate their addiction. In this double-blind study of 35 mildly depressed patients in a methadone maintenance program, subjects who received doxepin improved significantly more than control subjects. Even in this short-term study, the reduction in depression was associated with a trend toward better performance in other areas of rehabilitation.
mesh_terms: D000284:Administration, Oral; D000328:Adult; D000435:Alcoholic Intoxication; D000661:Amphetamine; D001007:Anxiety / Q000187:drug effects; D001463:Barbiturates; D002214:Capsules; D002986:Clinical Trials as Topic; D003863:Depression / Q000150:complications* / Q000188:drug therapy; D004316:Doxepin / Q000008:administration & dosage / Q000627:therapeutic use*; D004341:Drug Evaluation; D004347:Drug Interactions; D004359:Drug Therapy, Combination; D006556:Heroin Dependence / Q000188:drug therapy*; D006801:Humans; D008297:Male; D008691:Methadone / Q000008:administration & dosage / Q000627:therapeutic use*; D008875:Middle Aged; D010352:Patient Dropouts; D010919:Placebos; D011569:Psychiatric Status Rating Scales
chemical_list: D001463:Barbiturates; D002214:Capsules; D010919:Placebos; D004316:Doxepin; D000661:Amphetamine; D008691:Methadone