The effect of aprotinin on the harmine-induced tremor in lymphostatic encephalopathic and normal rats.
In normal and lymphostatic encephalopathic rats, aprotinin pretreatment alters the duration of the harmine tremor and the cerebral concentration of the alkaloid; low doses shorten the tremor and decrease the concentration, a high dose causes the opposite. Aprotinin may decrease or increase the blood-brain barrier permeability of harmine. Because the findings are similar in both groups of rats the blood-brain barrier for harmine is assumed to be intact in lymphostatic encephalopathy. However, sick rats possibly suffer from an impaired cerebral elimination of harmine.
D000470:Alkaloids / Q000494:pharmacology*; D000818:Animals; D007611:Aprotinin / Q000494:pharmacology*; D001798:Blood Proteins / Q000378:metabolism; D001923:Brain Chemistry / Q000187:drug effects; D001927:Brain Diseases / Q000503:physiopathology*; D006247:Harmine / Q000494:pharmacology*; D008198:Lymph Nodes / Q000502:physiology; D008297:Male; D011485:Protein Binding; D051381:Rats; D013997:Time Factors; D014202:Tremor / Q000139:chemically induced*
D000470:Alkaloids; D001798:Blood Proteins; D006247:Harmine; D007611:Aprotinin