Initial stages of differentiation of thymocytes in the plasma membrane.
There is some evidence in the plasma membrane after binding of molecules triggering differentiation processes that different membrane areas exist possessing different functions. We have tried to isolate these different membrane areas, using a type of affinity chromatography on Con A-Sepharose. Our results from binding sites, affinity constant and fatty acid composition seem to reinforce the evidence that heterogeneous plasma membrane areas exist having different functions in the proliferation and differentiation process of thymocytes after triggering with Con A.
D000217:Acyltransferases / Q000378:metabolism; D000818:Animals; D001665:Binding Sites; D002454:Cell Differentiation; D002462:Cell Membrane / Q000378:metabolism / Q000502:physiology*; D002784:Cholesterol / Q000378:metabolism; D002846:Chromatography, Affinity; D003208:Concanavalin A / Q000378:metabolism; D008213:Lymphocyte Activation; D010743:Phospholipids / Q000378:metabolism; D011817:Rabbits; D011955:Receptors, Drug; D013601:T-Lymphocytes / Q000648:ultrastructure*
D010743:Phospholipids; D011955:Receptors, Drug; D003208:Concanavalin A; D002784:Cholesterol; D000217:Acyltransferases