title: Coexistent lymphoid interstitial pneumonia, pernicious anemia, and agammaglobulinemia.
abstract: Immunologic factors have been incriminated in the pathogenesis of lymphoid interstitial pneumonia. The discovery of a patient with coexistent lymphoid interestitial pneumonia, pernicious anemia, and common variable hypogammaglobulinemia focused attention on the possible autoimmune nature of this pulmonary disease. Extensive immunologic studies demonstrated a noticeably impaired bonemarrow-dependent (B cell) system and intact thymus-dependent (T cell) system. No evidence of humoral or cellular hypersensitivity to homologous lung determinants was found.
mesh_terms: D000361:Agammaglobulinemia / Q000150:complications* / Q000276:immunology; D000752:Anemia, Pernicious / Q000150:complications* / Q000276:immunology; D001323:Autoantibodies / Q000032:analysis; D001327:Autoimmune Diseases / Q000150:complications*; D001402:B-Lymphocytes / Q000276:immunology; D005260:Female; D006801:Humans; D007111:Immunity, Cellular; D008168:Lung / Q000276:immunology; D008875:Middle Aged; D011658:Pulmonary Fibrosis / Q000150:complications* / Q000276:immunology; D013601:T-Lymphocytes / Q000276:immunology
chemical_list: D001323:Autoantibodies