title: Atrial receptors and renal function.
abstract: The hypothesis that receptors in the heart or pulmonary vasculature initiate a reflex that influences urine flow was derived from experiments designed to evaluate the effect of mechanical ventilation on renal function.  These experiments indicated that urine flow usually decreases during positive-pressure breathing and usually increases during negative-pressure breathing.  It was surmised that impulses from certain cardiopulmonary receptors affect the secretion of ADH, which in turn influences urine flow.  A subsequent investigation appeared to localize the pertinent receptors to the left atrium, but the results of this particular investigation were influenced by several complication factors that have not been widely appreciated.  The apparent localization of volume-regulating recpetors to the left atrium and the accumulating evidence that atrial receptors do respond to changes in atrial pressure or atrial volume triggered a myriad of further studies on the function of left receptors.  Nearly all these studies employed indirect techniques that produced changes in systemic and pulmonary hemodynamics in addition to changes in left atrial pressure.  Nevertheless, it often was assumed that if changes in left pressure were produced, any concomitant changes in circulating ADH or in urine flow were attributable to a reflex elicited from atrial receptors.  Mush of the data obtained were interpreted as being compatible with the elft atrial volume-receptor hypothesis, but very liggle of the data pertained to left atrial receptors specifically.
mesh_terms: D000818:Animals; D016275:Atrial Function; D001681:Biological Assay; D001794:Blood Pressure; D001810:Blood Volume; D006348:Cardiac Surgical Procedures; D002305:Cardiac Tamponade; D003714:Denervation; D004231:Diuresis; D004285:Dogs; D005110:Extracellular Space; D006333:Heart Failure / Q000503:physiopathology; D006470:Hemorrhage; D007031:Hypothalamus / Q000502:physiology; D007101:Immersion; D007668:Kidney / Q000098:blood supply / Q000502:physiology*; D008465:Mechanoreceptors / Q000502:physiology; D009318:Natriuresis; D009413:Nerve Fibers, Myelinated / Q000502:physiology; D011175:Positive-Pressure Respiration; D011187:Posture; D011863:Radioimmunoassay; D012039:Regional Blood Flow; D011984:Sensory Receptor Cells / Q000502:physiology*; D013610:Tachycardia / Q000652:urine; D014628:Vagotomy; D014630:Vagus Nerve / Q000502:physiology; D014667:Vasopressins / Q000032:analysis; D014701:Veratridine / Q000494:pharmacology
chemical_list: D014667:Vasopressins; D014701:Veratridine