title: Effect of ascorbic acid on the human electroencephalogram.
abstract: Controversy exists over whether ascorbic acid (vitamin C) in doses in excess of known physiological requirements has demonstrable biological effects. The present study reports that such megadoses of vitamin C do significantly effect an objective electrophysiological measure, i.e., electroencephalogram (EEG) driving responses to photic stimulation. Four thousand milligrams of vitamin C administered 27 and 3 hours prior to assessment produced an effect on the EEGs of 18 healthy adolescent human males that was significantly different from a placebo. Fifty milligrams of ascorbic acid administered in this manner did not produce an effect on the EEG significantly different from placebo administration.
mesh_terms: D000293:Adolescent; D001205:Ascorbic Acid / Q000494:pharmacology*; D002986:Clinical Trials as Topic; D004305:Dose-Response Relationship, Drug; D004569:Electroencephalography; D006801:Humans; D008297:Male; D010775:Photic Stimulation; D010919:Placebos
chemical_list: D010919:Placebos; D001205:Ascorbic Acid