Gastric secretory inhibition by two 16-methylated analogs of prostaglandin E2 given intragastrically to patients with duodenal ulcer disease.
The effects of two methylated analogs of prostaglandin E2 (PGE2), namely 16,16-dimethyl PGE2 and its methyl ester, on gastric acid and pepsin secretion have been studied in 5 ulcer patients. Both analogs produced significant inhibition of acid secretion in a dose-dependent fashion, but the effect was less pronounced than the inhibition found in a group of healthy volunteers, and it was necessary to give 140 mug of each analog to reach about the ED50. The mean values of pepsin output and pepsin concentration were decreased following administration of PGE2, but the individual results varied.
D000328:Adult; D003037:Cobalt Radioisotopes; D003864:Depression, Chemical; D004305:Dose-Response Relationship, Drug; D004381:Duodenal Ulcer / Q000378:metabolism*; D005750:Gastric Juice / Q000378:metabolism*; D006801:Humans; D008297:Male; D008745:Methylation; D008875:Middle Aged; D010434:Pepsin A / Q000378:metabolism*; D011453:Prostaglandins / Q000008:administration & dosage / Q000494:pharmacology*; D012636:Secretory Rate / Q000187:drug effects; D013268:Stimulation, Chemical; D014805:Vitamin B 12 / Q000378:metabolism
D003037:Cobalt Radioisotopes; D011453:Prostaglandins; D010434:Pepsin A; D014805:Vitamin B 12