The search for a human equivalent of the mouse T-locus - negative results from a study of HL-A types in spina bifida.
The spina bifida/anencephaly complex in man in some ways resembles the effects of T-locus mutants in the mouse. To test the hypothesis that these entities are genetically related, HL-A typing was performed in families with multiple cases of central nervous system abnormality. No evidence of linkage was found between HL-A type and the congenital malformation.
D000818:Animals; D002648:Child; D005260:Female; D008040:Genetic Linkage; D006680:HLA Antigens; D006649:Histocompatibility Antigens; D006650:Histocompatibility Testing; D006801:Humans; D008297:Male; D051379:Mice; D009154:Mutation; D016135:Spinal Dysraphism / Q000235:genetics / Q000276:immunology*
D006680:HLA Antigens; D006649:Histocompatibility Antigens