title: Enhancement of skin grafts in the mouse. The combined used of specific and nonspecific immunosuppression.
abstract: Enhancement of skin grafts in mice by passively administered alloantiserum was examined in conjunction with the simultaneous use of other immunosuppressive regimens. It could be clearly shown that when a "weak" antilymphocyte serum (ALS) was used, a significant further prolongation of graft survival occurred over that obtained with the enhancing antiserum alone, and these two separate effects were synergistic. When a "strong" ALS was used, no synergistic effects were apparent unless the enhancing alloantiserum was given almost continuously. A similar, but less impressive synergism was seen when the enhancing alloantiserum and azathioprine were used together. Azathioprine, like ALS, presumably acts on T cells, whereas drugs directed against B cells, such as cyclophosphamide and prednisolone, failed to show any synergistic effect.
mesh_terms: D000818:Animals; D000918:Antibody Specificity; D000961:Antilymphocyte Serum; D001202:Ascitic Fluid / Q000276:immunology; D001379:Azathioprine / Q000627:therapeutic use; D003520:Cyclophosphamide / Q000627:therapeutic use; D006041:Goats / Q000276:immunology; D006084:Graft Rejection / Q000517:prevention & control; D007106:Immune Sera; D007165:Immunosuppression Therapy / Q000379:methods*; D008198:Lymph Nodes / Q000166:cytology; D008214:Lymphocytes / Q000276:immunology; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D008810:Mice, Inbred C57BL; D011239:Prednisolone / Q000627:therapeutic use; D011817:Rabbits / Q000276:immunology; D016038:Skin Transplantation; D013154:Spleen / Q000166:cytology; D013950:Thymus Gland / Q000166:cytology; D014181:Transplantation Immunology; D014184:Transplantation, Homologous
chemical_list: D000961:Antilymphocyte Serum; D007106:Immune Sera; D003520:Cyclophosphamide; D011239:Prednisolone; D001379:Azathioprine