Immunologic study of nonsyphilitic interstitial keratitis with vestibuloauditory symptoms.
We studied four patients with the clinical entity of nonsyphilitic interstitial keratitis and vestibuloauditory symptoms to determine whether immunologic abnormalities play a role in its pathophysiology. There was no evidence of alteration in nonspecific cell-mediated or humoral immunologic status of any of the patients studied. Three of the four patients had W-17, a histocompatibility antigen that occurs in 3 to 10% of the normal population. All four patients had increased cell-mediated immunity against normal allogenic corneal antigens compared to normal control subjects. There seems to be no apparent generalized alteration of the immune system in this syndrome.
D000293:Adolescent; D000328:Adult; D000917:Antibody Formation; D002986:Clinical Trials as Topic; D003315:Cornea / Q000276:immunology; D003638:Deafness / Q000150:complications; D005260:Female; D006680:HLA Antigens; D006649:Histocompatibility Antigens; D006801:Humans; D007111:Immunity, Cellular; D007519:Isoantigens; D007634:Keratitis / Q000150:complications / Q000276:immunology*; D008875:Middle Aged
D006680:HLA Antigens; D006649:Histocompatibility Antigens; D007519:Isoantigens