Defective erythropoietic responses of aged mice not improved by young marrow.
Defective responses to severe bleeding in 25-mo.-old C57BL/6J mice were not improved by injections of 8-mo.-old marrow cells. Such injections greatly improved responses of genetically anemic W/W-v mice that have defective erythropoietic stem cells. Apparently the defective responses of old mice were not intrinsic to their erythropoietic stem cells.
D000375:Aging; D000741:Anemia, Aplastic / Q000235:genetics / Q000628:therapy*; D000818:Animals; D001815:Bloodletting; D001854:Bone Marrow Cells; D016026:Bone Marrow Transplantation; D004920:Erythropoiesis; D005260:Female; D006412:Hematopoietic Stem Cells / Q000502:physiology; D051379:Mice; D008810:Mice, Inbred C57BL; D014184:Transplantation, Homologous