Antihypertensive effect of beta-1 receptor blockade and beta-2-receptor stimulation in essential hypertension.
The antihypertensive effect of practolol, a beta-1-blocker, alone and in combination with a beta-2-stimulating drug, salbutamol, has been studied in a double-blind cross-over trial on 19 patients. Practolol treatment induced a significant BP reduction, while the addition of salbutamol failed to give any further decrease.
D000420:Albuterol / Q000627:therapeutic use*; D001794:Blood Pressure; D002986:Clinical Trials as Topic; D004359:Drug Therapy, Combination; D005260:Female; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D006973:Hypertension / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged; D010919:Placebos; D011217:Practolol / Q000627:therapeutic use*
D010919:Placebos; D000420:Albuterol; D011217:Practolol