Protection of the ischemic liver by donor pretreatment before transplantation.
Canine livers ischemically damaged for thirty minutes prior to auxiliary transplantation did not survive for long periods of time unless a combination of isoproterenol, allopurinol, and heparin was administered intravenously to the donor animal before the ischemic damage. These drugs had no protective effect when given individually. Ischemic livers treated with adenosine prior to transplantation also showed no improved recovery of function.
D000241:Adenosine / Q000494:pharmacology*; D000493:Allopurinol / Q000494:pharmacology*; D000818:Animals; D004285:Dogs; D006493:Heparin / Q000494:pharmacology*; D007511:Ischemia / Q000517:prevention & control; D007545:Isoproterenol / Q000494:pharmacology*; D008099:Liver / Q000098:blood supply / Q000187:drug effects; D008102:Liver Circulation / Q000187:drug effects*; D008111:Liver Function Tests; D016031:Liver Transplantation; D014019:Tissue Donors; D014184:Transplantation, Homologous
D000493:Allopurinol; D006493:Heparin; D000241:Adenosine; D007545:Isoproterenol