Genetic control of cutaneous basophil hypersensitivity.
CBH to DNP-GL could be elicited only in responder guinea pigs which possess the genetic ability to develop classic delayed type hypersensitivity to DNP-PLL, the response to which is governed by the same gene. Since the defect in nonresponder animals seems to reside at the level of their T cells and not B cells, these results lend support to the contention that CBH, as well as DH, is dependent on and probably mediated by T cells.
D000818:Animals; D001491:Basophils / Q000276:immunology*; D005260:Female; D005796:Genes; D006168:Guinea Pigs; D006648:Histocompatibility; D006968:Hypersensitivity, Delayed / Q000235:genetics*; D012882:Skin Tests; D013601:T-Lymphocytes / Q000276:immunology*