Reduction of acute tubular necrosis (ATN) by furosemide and steroids in cadaveric kidney recovery.
One hundred fifty human cadaver kidneys have been preserved by a combination of topical hypothermia and pulsatile perfusion with cryoprecipitated plasma in our laboratory. Post-transplant acute renal failure was reduced from 58 to 21 per cent in those kidneys protected with furosemide and methylprednisolone.
D058186:Acute Kidney Injury / Q000517:prevention & control*; D000293:Adolescent; D000328:Adult; D000368:Aged; D002102:Cadaver; D002648:Child; D002675:Child, Preschool; D004341:Drug Evaluation; D005260:Female; D005665:Furosemide / Q000494:pharmacology*; D006801:Humans; D016030:Kidney Transplantation; D007683:Kidney Tubular Necrosis, Acute / Q000517:prevention & control*; D008297:Male; D008775:Methylprednisolone / Q000494:pharmacology*; D008875:Middle Aged; D009926:Organ Preservation / Q000379:methods*; D010477:Perfusion / Q000379:methods*; D012034:Refrigeration; D013997:Time Factors; D014019:Tissue Donors; D014021:Tissue Preservation / Q000379:methods*; D014184:Transplantation, Homologous
D005665:Furosemide; D008775:Methylprednisolone