[Drug induced acute renal failure after heart surgery (author's transl)].
The incidence of acute renal failure following cardiac surgery was markedly increased during the last years in our medical center. There was no correlation to known etiologic factors such as preexisting disease, hemolysis, low perfusion rates, post-operative low output syndrome etc. Post-operative renal failure was mainly seen in children between 2 and 10 years and was noted after 3-4 days of normal renal function. Peritoneal dialysis was carried out in 39% of out patients and the overall mortality was 10.7%. Careful analysis of our cases exhibited a correlation of the post operative acute renal failure to the intravenous application of Aescin. After abandoning this drug from our post-operative therapy we did not observe a similar case since almost one year.
D058186:Acute Kidney Injury / Q000139:chemically induced* / Q000175:diagnosis / Q000628:therapy; D002648:Child; D002675:Child, Preschool; D004928:Escin / Q000009:adverse effects*; D005260:Female; D006331:Heart Diseases / Q000601:surgery; D006801:Humans; D010530:Peritoneal Dialysis; D011183:Postoperative Complications / Q000139:chemically induced*; D012503:Saponins / Q000009:adverse effects*; D013997:Time Factors
D012503:Saponins; D004928:Escin
Medikamentös bedingtes post-operatives Nierenversagen nach herzchirurgischen Eingriffen