title: [Substitution of T-cell function by poly-4-vinypyridine in the formation of the primary and secondary immune response].
abstract: The influence of poly-4-vinylpiridine (P-4-VP) on the production of antibody forming cells (AFC) has been studied. P-4-VP induces helper activity in lymphoid organs of B-mice. P-4-VP injected into mice substitutes T cell function in the development of immunological memory. The possibility of substitution by P-4-VP of various functions or of different subpopulations of T cells in T cell-deprived mice is discussed.
mesh_terms: D000818:Animals; D000921:Antibody-Producing Cells / Q000187:drug effects / Q000528:radiation effects; D001853:Bone Marrow / Q000187:drug effects; D001854:Bone Marrow Cells; D007109:Immunity / Q000187:drug effects*; D007156:Immunologic Memory / Q000187:drug effects; D008198:Lymph Nodes / Q000187:drug effects; D008221:Lymphoid Tissue / Q000187:drug effects; D051379:Mice; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D011144:Polyvinylpyridine N-Oxide / Q000276:immunology*; D011145:Polyvinyls / Q000276:immunology*; D011830:Radiation Effects; D013154:Spleen / Q000187:drug effects; D013601:T-Lymphocytes / Q000187:drug effects / Q000276:immunology*; D013934:Thymectomy; D013950:Thymus Gland / Q000528:radiation effects
chemical_list: D011145:Polyvinyls; D011144:Polyvinylpyridine N-Oxide
vernacular_title: Zameshchenie funktsii T-kletok poli-4-vinilpiridinom pri formirovanii pervichnogo i vtorichnogo immunnogo otveta