Genetic control of immune responses in vitro. VI. Experimental conditions for the development of helper T-cell activity specific for the terpolymer L-glutamic aicd60-L-alanine30-L-tyrosine10 (GAT) in nonresponder mice.
Mice which are genetic nonresponders to the random terpolymer of L-glutamic acid60-L-alanine30-L-tyrosine10 (GAT) not only fail to develop GAT-specific antibody responses when stimulated with soluble GAT either in vivo or in vitro, but develop GAT-specific T cells which suppress the GAT-specific plaque-forming cell response of normal nonresponder mice stimulated with GAT complexed to methylated bovine serum albumin (MBSA).Thus, both responder and nonresponder mice have T cells which recognize GAT. However, nonresponder mice can develop GAT-specific helper T cells if immunized with GAT bound to MBSA or to macrophages. The relevance of Ir gene-controlled responses is discussed.
D000367:Age Factors; D000409:Alanine; D000818:Animals; D000921:Antibody-Producing Cells; D000941:Antigens; D002874:Chromosome Mapping; D005971:Glutamates; D006649:Histocompatibility Antigens; D007274:Injections, Intraperitoneal; D051379:Mice; D008810:Mice, Inbred C57BL; D008811:Mice, Inbred DBA; D008970:Molecular Weight; D010567:Pertussis Vaccine / Q000008:administration & dosage; D011108:Polymers / Q000276:immunology*; D011830:Radiation Effects; D013154:Spleen / Q000276:immunology; D013601:T-Lymphocytes / Q000276:immunology* / Q000528:radiation effects; D014443:Tyrosine
D000941:Antigens; D005971:Glutamates; D006649:Histocompatibility Antigens; D010567:Pertussis Vaccine; D011108:Polymers; D014443:Tyrosine; D000409:Alanine