Nystatin and amphotericin B in the treatment of denture-related candidiasis.
A double-blind trial of nystatin, amphotericin B, and a placebo was carried out in fifty-two cases of denture-related candidiasis and/or angular cheilitis. The drugs effected a significant clinical cure, but recurrence of the signs was common after withdrawal of the drugs. Concurrent bacteriologic examination showed few cures and continued presence of Candida albicans during the trial. A specimen from a red palate was examined histologically.
D000666:Amphotericin B / Q000627:therapeutic use*; D001808:Blood Vessels / Q000648:ultrastructure; D002176:Candida albicans / Q000302:isolation & purification; D002180:Candidiasis, Oral / Q000188:drug therapy* / Q000209:etiology / Q000382:microbiology; D002613:Cheilitis / Q000188:drug therapy / Q000209:etiology / Q000382:microbiology; D003827:Denture, Complete, Upper / Q000009:adverse effects*; D004848:Epithelium / Q000648:ultrastructure; D006801:Humans; D009761:Nystatin / Q000627:therapeutic use*; D010159:Palate / Q000098:blood supply / Q000648:ultrastructure; D010919:Placebos; D013280:Stomatitis / Q000150:complications*; D013282:Stomatitis, Denture / Q000150:complications* / Q000473:pathology
D010919:Placebos; D009761:Nystatin; D000666:Amphotericin B