title: In vitro effects of zinc chloride on spontaneous sheep red blood cell (e) rosette formation by lymphocytes from cancer patients and normal subjects.
abstract: The in vitro spontaneous formation of sheep red blood cell (SRBC) (E) rosettes by peripheral blood lymphocytes is altered in vitro by the addition of micro-molar quantities of zinc chloride. Appropriate concentrations of zinc chloride cause marked enhancement of rosette formation, both in normal subjects and in cancer patients with low initial E rosette values. The effect is dependent upon zinc treatment of the lymphocyte and not the SRBC. Other zinc-induced effects on E rosettes include retardation of temperature-dependent spontaneous decay, increased mechanical stability due to enhanced of "capping." The formation of EAC rosettes is not altered by the presence of zinc.
mesh_terms: D000818:Animals; D002712:Chlorides / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D006801:Humans; D007104:Immune Adherence Reaction; D008214:Lymphocytes / Q000276:immunology*; D009000:Monocytes / Q000276:immunology*; D009369:Neoplasms / Q000276:immunology*; D012756:Sheep; D013601:T-Lymphocytes / Q000276:immunology; D013997:Time Factors; D015032:Zinc / Q000494:pharmacology*
chemical_list: D002712:Chlorides; D015032:Zinc