title: [Antifibrinolytic and antimycotic properties of 2-thiontetrahydro-1,3,5-thiadiazine].
abstract: A series of tetrahydro-1,3,5-thiadiazine-2-thiones have been tested for their fungistatic and antifibrinolytic effects. The fungistatic activity depends upon the substitution of nitrogen in positions 3 and 5 of the ring system. But it is, however, only the derivatives that are able to split off the antifibrinolytically active w-amino acids by solvolysis which produces antifibrinolytic effect in vivo.
mesh_terms: D010129:4-Aminobenzoic Acid / Q000494:pharmacology; D015119:Aminocaproic Acid / Q000494:pharmacology; D000818:Animals; D000933:Antifibrinolytic Agents; D000935:Antifungal Agents; D005342:Fibrinolysis / Q000187:drug effects; D066298:In Vitro Techniques; D011817:Rabbits; D013829:Thiadiazines / Q000494:pharmacology*; D013843:Thiazines / Q000494:pharmacology*; D014249:Trichophyton / Q000187:drug effects
chemical_list: D000933:Antifibrinolytic Agents; D000935:Antifungal Agents; D013829:Thiadiazines; D013843:Thiazines; D010129:4-Aminobenzoic Acid; D015119:Aminocaproic Acid
vernacular_title: Antifibrinoliticheskie i antimikoticheskie svoĭstva 2-tiontetragidro-1,3,5-tiadiazina.