The influence of x-rays, vitamin A and protease inhibitor on the hydroproteolytic activity and serotonin content in pancreas and intestine of rats.
Activity of MAO, hydroproteolytic enzymes including some lysosomal markers as well as serotonin content were examined in pancreas and intestinal tissue of rats 24 hours after irradiation with the dose of 800R. It was stated that postirradiation disturbances of enzymatic activity in intestinal tract were accompanied by changes of serotonin content. Administration of vitamin A into rats caused in some parts of the intestine slight increase of acid phosphatase activity-and evident changes in serotonin content. Inhibitor of proteases (Trasylol) evidently prevented the disturbances of serotonin content both in rats exposed to X-rays or vitamin A administration- when simultaneously its influence on changes in hydroproteolytic activity (except of pancreas and colon) was of smaller degree.
D000135:Acid Phosphatase / Q000032:analysis; D000818:Animals; D007611:Aprotinin / Q000494:pharmacology*; D005260:Female; D007413:Intestinal Mucosa / Q000378:metabolism*; D007422:Intestines / Q000032:analysis / Q000201:enzymology; D008297:Male; D008995:Monoamine Oxidase / Q000032:analysis; D010179:Pancreas / Q000032:analysis / Q000187:drug effects / Q000201:enzymology / Q000378:metabolism* / Q000528:radiation effects; D011830:Radiation Effects; D051381:Rats; D012701:Serotonin / Q000032:analysis* / Q000378:metabolism; D013997:Time Factors; D014801:Vitamin A / Q000494:pharmacology*
D014801:Vitamin A; D012701:Serotonin; D007611:Aprotinin; D008995:Monoamine Oxidase; D000135:Acid Phosphatase