title: Prophage induction and inactivation by UV light.
abstract: Analysis of the induction curves for UV light-irradiated Haemophilus influenzae lysogens and the distribution of pyrimidine dimers in a repair-deficient lysogen suggests that one dimer per prophage-size segment of the host bacterial chromosome is necessary as a preinduction event. The close correlations obtained prompted a renewed consideration of the possibility that direct prophage induction occurs when one dimer is stabilized within the prophage genome. The host excision-repair system apparently functions to reduce the probability of "stabilizing" within the prophage those dimers that are necessary for induction and inactivation. The presence of the inducible defective prophage in strain Rd depresses the inducibility of prophage HP1c1.
mesh_terms: D001435:Bacteriophages / Q000254:growth & development* / Q000528:radiation effects; D004260:DNA Repair; D004269:DNA, Bacterial / Q000096:biosynthesis; D006193:Haemophilus influenzae / Q000378:metabolism / Q000528:radiation effects; D008242:Lysogeny; D009154:Mutation; D011830:Radiation Effects; D014466:Ultraviolet Rays; D014779:Virus Replication / Q000528:radiation effects
chemical_list: D004269:DNA, Bacterial