[The action of triglycylvasopressin on control subjects and patients with upper gastrointestinal bleeding (author's transl)].
Nalpha-glycyl-glycyl-glycyl-(8-lysine)-vasopressin, a hormone analogue with prolonged pharmacological action due to slow release of active nonapeptide by enzyme action in vivo, has been administered to 5 control subjects and to 14 patients actively bleeding from upper gastrointestinal sites. The control subjects showed a prolonged pressor response to 100mug/kg body weight associated with a rise in cardiac output, with no ECG signs of myocardial toxicity. 13 of the 14 bleeding patients showed not only pressor responses and haemodynamic and clinical improvement when administering doses of 20-100 mug/kg, but clear signs of standstill of upper gastrointestinal bleeding.
D000293:Adolescent; D000328:Adult; D000368:Aged; D000818:Animals; D003085:Colic / Q000139:chemically induced; D003672:Defecation / Q000187:drug effects; D004285:Dogs; D004932:Esophageal and Gastric Varices / Q000188:drug therapy; D005260:Female; D006471:Gastrointestinal Hemorrhage / Q000188:drug therapy*; D005998:Glycine / Q000494:pharmacology*; D006321:Heart / Q000187:drug effects; D006439:Hemodynamics / Q000187:drug effects; D006801:Humans; D008236:Lypressin / Q000031:analogs & derivatives / Q000378:metabolism / Q000494:pharmacology; D008297:Male; D008875:Middle Aged; D009325:Nausea / Q000139:chemically induced; D010438:Peptic Ulcer Hemorrhage / Q000188:drug therapy; D013546:Sweating / Q000187:drug effects; D014554:Urination / Q000187:drug effects; D014667:Vasopressins / Q000009:adverse effects / Q000031:analogs & derivatives* / Q000494:pharmacology*
D014667:Vasopressins; D008236:Lypressin; D005998:Glycine
Die Wirkung von Triglycyl-Lysin-Vasopressin auf Kontrollpersonen und Patienten mit Blutungen des oberen Gastrointestinaltraktes