An analysis of the defective response of CBA/N mice to T-dependent antigens.
CBA/N mice fail to respond to T-independent antigens, and give a diminished response to T-dependent antigens. The cellular basis of the diminished response to T-dependent antigens in this strain was analyzed by means of adoptive transfers of various primed cell populations along with cells from the immunologically normal, histocompatible strain CBA/CaJ. CBA/N mice behaved normally as recipients and had normal levels of spleen helper cell activity. However, CBA/N spleen cells, used as a B cell source, produced only 56% as much antibody as CBA/CaJ cells. Since CBA/N mice have a relative frequency of immunoglobulin-bearing lymphocytes roughly half that of normal mice, these results suggest that CBA/N mice have a quantitative defect in spleen B cells responsive to T-dependent antigens.
D000818:Animals; D000917:Antibody Formation / Q000187:drug effects*; D000941:Antigens; D001402:B-Lymphocytes / Q000187:drug effects; D004140:Dinitrophenols / Q000276:immunology; D005260:Female; D006433:Hemocyanins / Q000494:pharmacology; D007111:Immunity, Cellular / Q000187:drug effects; D007115:Immunization Schedule; D051379:Mice; D008808:Mice, Inbred CBA / Q000276:immunology*; D010047:Ovalbumin / Q000494:pharmacology; D012710:Serum Albumin, Bovine / Q000494:pharmacology; D013154:Spleen / Q000276:immunology; D013601:T-Lymphocytes / Q000276:immunology*
D000941:Antigens; D004140:Dinitrophenols; D012710:Serum Albumin, Bovine; D010047:Ovalbumin; D006433:Hemocyanins