The influence of bretylium tosylate on the intraocular pressure of the rabbit.
Bretylium tosylate was applied topically and intravitreously to rabbit eyes. The topical application of 1, 2, 5 and 10% bretylium tosylate gave a small but significant decrease of the intraocular pressure 6 hrs after treatment. The effects had disappeared, when the eyes were re-examined after 24 hrs. The intravitreous injection of 200 mug of bretylium tosylate caused a more pronounced and prolonged pressure decrease. The results are interpreted in the light of chemical sympathectomy.
D000818:Animals; D001949:Bretylium Compounds / Q000494:pharmacology*; D001950:Bretylium Tosylate / Q000008:administration & dosage / Q000494:pharmacology*; D003864:Depression, Chemical; D005260:Female; D007267:Injections; D007429:Intraocular Pressure / Q000187:drug effects*; D008297:Male; D009883:Ophthalmic Solutions; D011817:Rabbits; D014822:Vitreous Body
D001949:Bretylium Compounds; D009883:Ophthalmic Solutions; D001950:Bretylium Tosylate