Studies on the effector cell of anti-tumour immunity in a chemically induced mouse tumour system.
Spleen cells from mice immunized against a methylcholanthrene induced rhabdomyosarcoma inhibited tumour cell colony formation in vitro and prevented tumour development in vivo in an adoptive transfer test. Treatment of the immune spleen cells with anti-mouse immunoglobulin serum or passage through a nylon wool column, both of which reduced the percentage of immunoglobulin bearing cells in the population to less than 3-4%, did not alter their anti-tumour effects. In contrast, treatment of the spleen cells with anti-BAomicron serum abolished their anti-tumour effects both in vitro and in vivo. These results indicate that T cells are the mediators of tumour immunity in this chemically induced tumour system.
D000818:Animals; D001402:B-Lymphocytes / Q000276:immunology; D003208:Concanavalin A / Q000494:pharmacology; D005260:Female; D007111:Immunity, Cellular; D007116:Immunization, Passive; D008070:Lipopolysaccharides / Q000494:pharmacology; D008748:Methylcholanthrene; D051379:Mice; D008811:Mice, Inbred DBA; D009374:Neoplasms, Experimental / Q000139:chemically induced / Q000276:immunology; D012208:Rhabdomyosarcoma / Q000139:chemically induced / Q000276:immunology*; D013154:Spleen / Q000276:immunology; D013601:T-Lymphocytes / Q000276:immunology
D008070:Lipopolysaccharides; D003208:Concanavalin A; D008748:Methylcholanthrene