title: Rickets then and now.
abstract: Since the introduction of irradiated ergosterol into our food supply, nutritional vitamin D-deficiency rickets has become an uncommon disease. However, skeletal disorders due to abnormalities of vitamin D function still occur. These disorders can now be classified more exactly into two groups: those in which there is a deficiency of the active metabolite of vitamin D, 1,25-dihydroxyvitamin D, and those in which there is an abnormality of renal tubular function resulting in renal hypophosphatemia despite normal vitamin D metabolism. The various entities of these two groups are described and the theoretical basis of their treatment given.
mesh_terms: D004097:Dihydrotachysterol / Q000627:therapeutic use; D005198:Fanconi Syndrome / Q000378:metabolism; D006029:Glycosuria / Q000378:metabolism; D006801:Humans; D006961:Hyperparathyroidism / Q000188:drug therapy; D006962:Hyperparathyroidism, Secondary / Q000378:metabolism; D007015:Hypophosphatemia, Familial / Q000188:drug therapy; D007223:Infant; D010018:Osteomalacia / Q000150:complications; D010710:Phosphates / Q000627:therapeutic use; D000608:Renal Aminoacidurias / Q000378:metabolism; D012279:Rickets / Q000145:classification / Q000150:complications / Q000378:metabolism*; D014807:Vitamin D / Q000627:therapeutic use; D014808:Vitamin D Deficiency / Q000378:metabolism*
chemical_list: D010710:Phosphates; D014807:Vitamin D; D004097:Dihydrotachysterol