In utero sensitization with influenza virus in man.
Following a community-wide epidemic of influenza A/England virus infection, 64 cord blood samples were evaluated for their fetal serum and lymphocyte responses to this virus. Cord sera were tested for HI antibody vs. A/England with and without 2-ME. A fourfold or greater reduction in titer was observed in four, indicating fetal IgM antibody responses. In addition, lymphocyte samples from three of 16 tested showed proliferative responses to influenza A suggesting fetal lymphocyte sensitization with influenza virus. These data suggest that, in some pregnancies, influenza virus is capable of transplacental sensitization of the fetus.
D005260:Female; D005312:Fetal Blood / Q000166:cytology / Q000276:immunology*; D005333:Fetus / Q000276:immunology; D006385:Hemagglutination Inhibition Tests; D006801:Humans; D007075:Immunoglobulin M / Q000032:analysis*; D007223:Infant; D007231:Infant, Newborn; D009980:Influenza A virus / Q000276:immunology*; D007251:Influenza, Human / Q000276:immunology; D008213:Lymphocyte Activation; D008623:Mercaptoethanol / Q000494:pharmacology; D009975:Orthomyxoviridae / Q000276:immunology*; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000276:immunology; D013601:T-Lymphocytes
D007075:Immunoglobulin M; D008623:Mercaptoethanol