Intranuclear inclusions in a case of Creutzfeldt-Jakob disease: an ultrastructural study.
Two types of intranuclear inclusions were described in a brain biopsy from a patient with Creutzfeldt-Jakob disease. The first type of intranculear inclusion was papova virus-like and was observed within 20% of the nuclei of all astrocytes and neurons examined. The particles measured 32 nm in diameter and consisted of a dense core surrounded by a multi-layered shell. The second type of intranuclear inculsion was a granulo-fibrillar nuclear body found within the nuclei of astrocytes and neurons. The possible significance of these inculsions to the etiology of Creutzfeldt-Jakob disease is discussed.
D001253:Astrocytes / Q000382:microbiology; D002467:Cell Nucleus / Q000382:microbiology; D007562:Creutzfeldt-Jakob Syndrome / Q000382:microbiology* / Q000473:pathology; D005260:Female; D006378:Helper Viruses / Q000032:analysis; D006801:Humans; D007181:Inclusion Bodies, Viral; D008854:Microscopy, Electron; D008875:Middle Aged; D009474:Neurons / Q000382:microbiology; D027383:Papillomaviridae / Q000032:analysis; D010316:Particle Size; D027382:Polyomaviridae