Cyclamates: a review of the current position.
Cyclamates were prohibited for use as food additives in the U.S.A. and other parts of the world during 1970 because of the fears of carcinogenicity. The author reviews the evidence leading to this ban and discusses the appeal made against the decision which led to the lifting of the cyclamate restrictions in Australia in November 1974.
D000818:Animals; D002273:Carcinogens / Q000009:adverse effects*; D002291:Carcinoma, Papillary / Q000139:chemically induced; D003494:Cyclamates / Q000008:administration & dosage / Q000009:adverse effects* / Q000378:metabolism; D003514:Cyclohexylamines / Q000009:adverse effects / Q000378:metabolism; D003922:Diabetes Mellitus, Type 1 / Q000178:diet therapy; D004305:Dose-Response Relationship, Drug; D005260:Female; D005503:Food Additives / Q000009:adverse effects; D006801:Humans; D007422:Intestines / Q000382:microbiology; D007928:Lethal Dose 50; D008297:Male; D009369:Neoplasms / Q000139:chemically induced*; D009374:Neoplasms, Experimental / Q000139:chemically induced; D011247:Pregnancy; D012439:Saccharin / Q000008:administration & dosage / Q000009:adverse effects; D014481:United States; D014486:United States Food and Drug Administration; D001749:Urinary Bladder Neoplasms / Q000139:chemically induced
D002273:Carcinogens; D003494:Cyclamates; D003514:Cyclohexylamines; D005503:Food Additives; D012439:Saccharin