Effects of protriptyline and perphenazine in neurotic depressed outpatients.
A four-week comparison of protriptyline 10 mg three times a day and perphenazine 2 mg three times a day, alone and in combination, and a placebo in a group of nonpsychotic depressed outpatients showed no significant differences among any of the treatment groups after both two and four weeks, and a slight trend in favor of the placebo group. A significant positive correlation was observed between changes in hostility and changes in depression, contrary to many commonly held assumptions regarding the relationship between hostility and depression.
D000275:Adjustment Disorders / Q000188:drug therapy*; D000328:Adult; D002986:Clinical Trials as Topic; D003986:Dibenzocycloheptenes / Q000627:therapeutic use*; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010044:Outpatient Clinics, Hospital; D010546:Perphenazine / Q000627:therapeutic use*; D010919:Placebos; D011530:Protriptyline / Q000627:therapeutic use*; D011569:Psychiatric Status Rating Scales
D003986:Dibenzocycloheptenes; D010919:Placebos; D011530:Protriptyline; D010546:Perphenazine