Suppression of autoimmunity in NZB mice with steroid-sensitive X-radiation-sensitive syngeneic young thymocytes.
NZB mice spontaneously lose thymic regulatory or suppressor cells and subsequently develop autoimmunity and lymphoreticular hyperplasia. Treatment with 2-week-old syngeneic thymocytes every 2 weeks starting at 4 weeks of age suppressed these disease manifestations. The active thymocyte subpopulation was found to be sensitive to corticosteroids and X-irradiation.
D000818:Animals; D001323:Autoantibodies; D003298:Coombs Test; D007109:Immunity / Q000187:drug effects / Q000528:radiation effects*; D007165:Immunosuppression Therapy; D007674:Kidney Diseases / Q000276:immunology; D008198:Lymph Nodes / Q000473:pathology; D008775:Methylprednisolone / Q000494:pharmacology*; D051379:Mice; D008814:Mice, Inbred NZB; D012157:Mononuclear Phagocyte System / Q000473:pathology; D013601:T-Lymphocytes / Q000187:drug effects / Q000528:radiation effects* / Q000637:transplantation; D014184:Transplantation, Homologous; D014965:X-Rays
D001323:Autoantibodies; D008775:Methylprednisolone