title: [Production and biological properties of L-like mutants (11r) of Escherichia coli].
abstract: Treatment of the strains of E. coli K12 with the mutagen N-nitroso-N-methylurea yielded mutants with the morphology similar to that of stable penicillin L-forms. Studies of the biological properties of the cultures have shown that the mutation of the gen 11r increases the susceptibility to antibiotics of various action spectra, ionic and non-ionic detergents and the resistance to UV and gamma radiation. Biochemical analysis of peptidoglycan from the cell walls of the parent bacterial cultures and L-mutants revealed no differences in its chemical composition.
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology; D003902:Detergents / Q000494:pharmacology; D004352:Drug Resistance, Microbial; D004926:Escherichia coli / Q000187:drug effects* / Q000528:radiation effects; D005720:Gamma Rays; D007740:L Forms / Q000187:drug effects / Q000528:radiation effects / Q000648:ultrastructure; D008770:Methylnitrosourea / Q000494:pharmacology; D009113:Muramidase / Q000494:pharmacology; D009153:Mutagens; D009154:Mutation; D011830:Radiation Effects; D014466:Ultraviolet Rays
chemical_list: D000900:Anti-Bacterial Agents; D003902:Detergents; D009153:Mutagens; D008770:Methylnitrosourea; D009113:Muramidase
vernacular_title: Poluchenie i biologicheskie svoĭstv L-podobnykh mutantov (11r) Escherichia coli]