[Cytogenetic effects of chloroquine in a culture of human lymphocytes].
Chloroquine added to human lymphocyte culture at the G1 stage had no influcence on the chromosome aberration level in the concentration of 15 mug/ml and suppressed the mitotic activity of the cells almost completely in the concentration of 60 and 100 mug/ml. At the G2 stage chloroquine in the concentration of 15 mug/ml had no cytogenetic effect and in the concentration of 100 mug/ml -- it increased the number of chromosome aberrations significantly.
D000328:Adult; D002478:Cells, Cultured; D002738:Chloroquine / Q000494:pharmacology*; D002869:Chromosome Aberrations / Q000187:drug effects*; D006801:Humans; D008214:Lymphocytes; D008938:Mitosis / Q000187:drug effects*; D012216:Rheumatic Diseases
D002738:Chloroquine
Izuchenie tsitogeneticheskikh éffektov khlorokhina v kul'ture limfotsitov cheloveka