title: [Focal myofibrillar disorganization in acute metabolic impairment of somatic musculature].
abstract: Skeletal muscles of rats and rabbits were studied by the target electron microscoptic and polarization-optic methods after administration of toxic substances and experimental acute ischemia of the extremities. Two types of foci of the myofibrillae disaggregation were described along with contracture injuries. The first occurred on the basis of relaxation and was expressed in total dysaggregation and lysis of myofibrillae; with the second type lysis occurred in the partially contracted fibers and began in the I-discs leading to diastasis of A-discs. The first type of the foci is characteristic chiefly of the white fibers, and the second one--of the red.
mesh_terms: D000208:Acute Disease; D000818:Animals; D002682:Chinchilla; D002712:Chlorides; D003035:Cobalt; D004167:Diphtheria Toxin; D007511:Ischemia / Q000473:pathology* / Q000503:physiopathology; D008297:Male; D008854:Microscopy, Electron; D008858:Microscopy, Phase-Contrast; D009132:Muscles / Q000098:blood supply / Q000473:pathology* / Q000648:ultrastructure; D009135:Muscular Diseases / Q000139:chemically induced / Q000209:etiology / Q000473:pathology*; D009210:Myofibrils / Q000648:ultrastructure; D010206:Papain; D010655:Phenylenediamines; D011817:Rabbits; D051381:Rats; D011919:Rats, Inbred Strains
chemical_list: D002712:Chlorides; D004167:Diphtheria Toxin; D010655:Phenylenediamines; D003035:Cobalt; D010206:Papain
vernacular_title: Ochagovaia dezagregatsiia miofibrill pri ostrykh metabolicheskikh povrezhdeniiakh somaticheskoĭ muskulatury