[Comparative clinical electroencephalographic study of cycloserine and terizidon tolerance].
The aim of the study was comparative investigation of cycloserin and terizidone tolerance by patients with the lung tuberculosis. The investigation procedure included parallel clinical observations and electroencephalographic studies (EEG) using light and sonic stimulation. Sixty six and 26 patients treated with cycloserin and terizidone respectively were observed. The results of the studies showed that by the mechanism of their action on the central nervous system terizidone and cycloserine were similar and increased the general reactivity of the brain. However, terizidone promoted an increase of the activating effect of the ascending part of the reticular formation of the brain stem to a lesser extent than cycloserine. Terizidone in a dose of 0.25 g 3 times a day was well tolerated by the patients with concomitant psycho-neurological impairements.
D000293:Adolescent; D000328:Adult; D000995:Antitubercular Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D002490:Central Nervous System / Q000187:drug effects / Q000503:physiopathology; D002908:Chronic Disease; D002986:Clinical Trials as Topic; D003523:Cycloserine / Q000008:administration & dosage / Q000031:analogs & derivatives / Q000627:therapeutic use*; D004361:Drug Tolerance; D004569:Electroencephalography; D006801:Humans; D007097:Imines / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged; D010080:Oxazoles / Q000627:therapeutic use*; D014397:Tuberculosis, Pulmonary / Q000188:drug therapy / Q000503:physiopathology
D000995:Antitubercular Agents; D007097:Imines; D010080:Oxazoles; D003523:Cycloserine
Sravnitel'noe kliniko-élektoréntsefalograficheskoe izuchenie perenosimosti tsikloserina i terizidona