title: Coronary artery surgery for recurrent ventricular arrhythmias in patients with variant angina.
abstract: Two patients with Prinzmetal's variant angina had recurrent episodes of resting chest pain, ST segment elevation, QRS widening, ventricular tachycardia, and ventricular fibrillation. These eqisodes were unresponsive to medical therapy including lidocaine, procaine amide, and quinidine sulfate. Coronary arteriography revealed severe obstructive coronary artery disease, involving more than one coronary artery, in both patients. Aorticocoronary saphenous vein grafts were utilized to bypass significant disease in each patient. In one patient blood flow through the grafts was measured at 90 and 65 ml per minute, respectively, at operation and patent grafts were demonstrated six months postoperatively. Neither patient has had recurrence of chest pain or evidence of ventricular tachycardia at one year or 2 1/2 years postoperatively. Postoperative resting and maximal exercise ECG's are normal. Coronary artery surgery may be an effective method of therapy for ischemic ventricular tachycardia when medical therapy fails.
mesh_terms: D000328:Adult; D000787:Angina Pectoris / Q000601:surgery*; D001145:Arrhythmias, Cardiac / Q000188:drug therapy / Q000601:surgery*; D001026:Coronary Artery Bypass; D004562:Electrocardiography; D006352:Heart Ventricles; D006801:Humans; D008012:Lidocaine / Q000627:therapeutic use; D008297:Male; D011342:Procainamide / Q000627:therapeutic use; D011802:Quinidine / Q000627:therapeutic use; D013610:Tachycardia / Q000601:surgery
chemical_list: D008012:Lidocaine; D011802:Quinidine; D011342:Procainamide