The mitogenic activity of polyadenylic-polyuridyclic acid complexes.
Polyadenylic-polyuridylic acid complexes (poly A:U) at the 1-5 mu g level, were mitogenic for spleen cells when given intravenously to normal Balb or cortisone-treated mice. Similarly, mitogenicity was evident when poly A:U was added to tissue culture fluids containing spleen cells from normal or cortisone-treated mice, or bone marrow cells from normal mice. Under these conditions, this adjuvant was not mitogenic for thymus cells or mesenteric lymph node cells, either in vivo or in vitro.
D000818:Animals; D000917:Antibody Formation / Q000187:drug effects*; D001853:Bone Marrow / Q000187:drug effects; D001854:Bone Marrow Cells; D002478:Cells, Cultured; D003348:Cortisone; D004912:Erythrocytes / Q000276:immunology; D008198:Lymph Nodes / Q000166:cytology; D008213:Lymphocyte Activation / Q000187:drug effects; D008214:Lymphocytes / Q000276:immunology; D051379:Mice; D008807:Mice, Inbred BALB C; D008934:Mitogens; D011063:Poly A-U / Q000494:pharmacology*; D012756:Sheep / Q000276:immunology; D013154:Spleen / Q000166:cytology; D013601:T-Lymphocytes / Q000276:immunology; D013936:Thymidine / Q000378:metabolism; D014316:Tritium
D008934:Mitogens; D014316:Tritium; D011063:Poly A-U; D003348:Cortisone; D013936:Thymidine