Gaseous persufflation during machine perfusion of human kidneys before transplantation.
Massive air embolisation (persufflation) of four machine-perfused human kidneys occurred during preservation. This lasted for 60-120 min and caused increasing perfusion resistance. Pressure and flow returned to normal within 2 h after reperfusion. All kidneys showed immediate function after transplantation. Experiments with dog kidneys revealed closure of cortical vessels and increased kidney temperature during persufflation. Cortical flow became normal after 1 h of reperfusion.
D000792:Angiography; D000818:Animals; D004285:Dogs; D006801:Humans; D007668:Kidney / Q000098:blood supply; D016030:Kidney Transplantation; D009926:Organ Preservation; D010477:Perfusion; D012039:Regional Blood Flow; D013997:Time Factors; D014021:Tissue Preservation; D014184:Transplantation, Homologous