[DNA repair in murine lupus].
DNA repair was investigated in New Zealand Mice strains which develop murine lupus, and compared with Swiss control mice. Unscheduled DNA synthesis demonstrated by autoriadiography was used to measure the repair capacity of spleen cells. After gamma-irradiation DNA repair was decreased in the autoimmune strains, while it was significantly increased after UV-irradiation. A possible relationship between repair capacity after gamma-respectively UV-irradiation and the etiologic factor of autoimmunity is discussed.
D000367:Age Factors; D000818:Animals; D000974:Antibodies, Antinuclear / Q000032:analysis; D002460:Cell Line; D004247:DNA / Q000096:biosynthesis; D004260:DNA Repair; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000378:metabolism*; D051379:Mice; D008814:Mice, Inbred NZB; D008819:Mice, Nude; D013154:Spleen / Q000378:metabolism / Q000528:radiation effects; D013936:Thymidine / Q000378:metabolism; D014466:Ultraviolet Rays
D000974:Antibodies, Antinuclear; D004247:DNA; D013936:Thymidine
Untersuchungen der DNA-Reparatur bei murinem Lupus