Stimulatory effect of prostaglandin E2 on LH release in the rat: evidence for hypothalamic site of action.
The intravenous administration of prostaglandin E2 (PGE2; 100 mug/rat) to immature male and female rats increased the serum level of lutenizing hormone (LH). This effect was prevented by the prior administration of an antiserum to the hypothalamic gonadotropin-releasing hormone. LH release from rat pituitaries in vitro was not stimulated by PGE2 (10 mug/ml). It is inferred that the stimulatory effect of PGE2, on LH release is not a direct one on the pituitary gland, but is exerted at the level of the hypothalamus.
D000818:Animals; D005260:Female; D007987:Gonadotropin-Releasing Hormone / Q000378:metabolism*; D007031:Hypothalamus / Q000187:drug effects* / Q000378:metabolism; D066298:In Vitro Techniques; D007986:Luteinizing Hormone / Q000097:blood / Q000378:metabolism*; D008297:Male; D011453:Prostaglandins / Q000494:pharmacology*; D051381:Rats
D011453:Prostaglandins; D007987:Gonadotropin-Releasing Hormone; D007986:Luteinizing Hormone