Association of a chromosomal abnormality with lymphocytes having both T and B markers in a patient with lymphoproliferative disease.
The lymphocytes of a patient with leukemic lymphosarcoma were found to have an unusual surface phenotype in that they bound both sheep erythrocytes (a T cell marker) and complement-coated erythrocytes (a B cell marker) but lacked other B cell surface characteristics. Marker chromosomes were present in these cells, but not in other, phenotypically normal cells from the same patient. This case may provide a clue to the chromosomal origin of some lymphocyte surface markers in man.
D000368:Aged; D001402:B-Lymphocytes / Q000276:immunology*; D001666:Binding Sites, Antibody; D002294:Carcinoma, Squamous Cell / Q000150:complications; D002462:Cell Membrane / Q000276:immunology; D002869:Chromosome Aberrations; D002901:Chromosomes, Human, 13-15; D002902:Chromosomes, Human, 16-18; D005260:Female; D006801:Humans; D007104:Immune Adherence Reaction; D007141:Immunoglobulin Fc Fragments; D007938:Leukemia / Q000150:complications / Q000235:genetics* / Q000276:immunology; D008175:Lung Neoplasms / Q000150:complications; D008213:Lymphocyte Activation; D010641:Phenotype; D010996:Pleural Effusion / Q000209:etiology; D013601:T-Lymphocytes / Q000276:immunology*
D007141:Immunoglobulin Fc Fragments