Studies of insulin release and rat pancreatic islet metabolism with diastereomers of D-glucose.
Studies of insulin release with diastereomers and other analogues of D-glucose demonstrated that only sugars which undergo oxidation to CO2 stimulated insulin release by the pancreatic islet. None of the non-metabolizable diastereomers of glucose stimulated insulin release in the presence of a sub-stimulatory concentration of glucose for fuel. Although 5.5 mM glucose formed 77% as much CO2 as 16.7 mM mannose and twice that of 16.7 mM fructose, 5.5 mM glucose did not stimulate insulin release whereas 16.7 mM mannose and fructose did stimulate insulin release. These results indicate that the important stimulus for glucose-induced insulin release involves metabolism of glucose, but that the stimulus does not involve solely a fuel function of glucose.
D000818:Animals; D002245:Carbon Dioxide / Q000378:metabolism; D005260:Female; D005944:Glucosamine / Q000378:metabolism; D005947:Glucose / Q000378:metabolism* / Q000494:pharmacology; D006601:Hexoses / Q000378:metabolism / Q000494:pharmacology; D007328:Insulin / Q000378:metabolism*; D000078790:Insulin Secretion; D007515:Islets of Langerhans / Q000378:metabolism*; D008759:Methylglycosides / Q000378:metabolism; D051381:Rats; D013237:Stereoisomerism; D013329:Structure-Activity Relationship
D006601:Hexoses; D007328:Insulin; D008759:Methylglycosides; D002245:Carbon Dioxide; D005947:Glucose; D005944:Glucosamine