Synaptosomal uptake and levels of serotonin in rat brain areas after p-chloroamphetamine or B-9 lesions.
In contrast to the pronounced fall in 5HT levels and synaptosomal uptake caused by p-chloroamphetamine, bilateral lesions of the B-9 cell group caused minimal regional changes, except for 35% decreases in the metathalamus-thalamus. We conclude therefore that the prolonged biochemical effects of p-chloroamphetamine are not due to a selective cytotoxic action on B-9 cells; and that a lateral 5HT pathway, possibly from the B-9 cell group, projects to the metathalamus-thalamus.
D000662:Amphetamines / Q000494:pharmacology*; D000818:Animals; D001921:Brain / Q000378:metabolism*; D008297:Male; D051381:Rats; D012154:Reticular Formation / Q000502:physiology*; D012701:Serotonin / Q000378:metabolism*; D013238:Stereotaxic Techniques; D013574:Synaptosomes / Q000378:metabolism*; D010133:p-Chloroamphetamine / Q000494:pharmacology*
D000662:Amphetamines; D012701:Serotonin; D010133:p-Chloroamphetamine