Effect of procaine hydrochloride on DNA repair in Escherichia coli.
Liquid-holding recovery and rejoining of gamma-radiation-induced DNA single-strand scissions in Escherichia coli could be effectively inhibited by procaine hydrochloride at the concentration of 20 mM. At this concentration, the drug also reversibly altered cellular permeability barrier as evidenced from the uptake of acriflavin by bacterial cells.
D000167:Acriflavine / Q000378:metabolism; D002462:Cell Membrane / Q000187:drug effects / Q000378:metabolism / Q000528:radiation effects; D004260:DNA Repair / Q000187:drug effects*; D004269:DNA, Bacterial / Q000096:biosynthesis* / Q000528:radiation effects; D004926:Escherichia coli / Q000187:drug effects / Q000378:metabolism* / Q000528:radiation effects; D009154:Mutation; D010539:Permeability; D011343:Procaine / Q000494:pharmacology*; D011830:Radiation Effects; D014466:Ultraviolet Rays
D004269:DNA, Bacterial; D000167:Acriflavine; D011343:Procaine