[Role of salivary kallikrein in the pathogenesis of periodontosis].
In patients with parodontosis the distinct increase in salivary kallikrein secretion was found. In Wistar rats the intensity of age atrophy of alveoli dentalis correlated with BAEE-esterase activity of mixed saliva. Desalivation considerably decreased the rate of age atrophy of parodontosis in rats. Salivary kallikrein, penetrating in active form into parodontal tissues, caused the pronounced vasodilation in dogs and golden hamsters. By means of kallikrein preparations an intensive inflammatory-dystrophical process was reproduced in parodontal tissues of Wistar rats. The local treatment of patients with parodontosis by kallikrein inhibitors was found to be especially effective.
D000096:Acetone / Q000494:pharmacology; D000375:Aging; D000539:Alveolar Process / Q000378:metabolism / Q000473:pathology; D000818:Animals; D007611:Aprotinin / Q000627:therapeutic use; D001284:Atrophy; D006224:Cricetinae; D004285:Dogs; D004950:Esterases / Q000378:metabolism; D005881:Gingiva / Q000378:metabolism; D006801:Humans; D066298:In Vitro Techniques; D007610:Kallikreins / Q000378:metabolism* / Q000494:pharmacology; D010518:Periodontitis / Q000188:drug therapy / Q000201:enzymology / Q000209:etiology*; D051381:Rats; D012463:Saliva / Q000201:enzymology*; D012469:Salivary Glands / Q000601:surgery
D000096:Acetone; D007611:Aprotinin; D004950:Esterases; D007610:Kallikreins
Rol' kallikreina sliuny v patogeneze parodontoza