Hepatic veno-occlusive disease in a renal transplant patient receiving azathioprine.
Central vein phlebitis and occlusion developed in a patient who was receiving immunosuppressive therapy with azathioprine (Imuran) and prednisone after renal transplantation. He had been well for 1 year before evidence of liver disease was noted; once begun, it progressed to hepatocellular failure in spite of a change in immunosuppressants from azathioprine to cyclophosphamide. Several known causes of venoocclusive disease and the possible causes in this patient are discussed.
D001379:Azathioprine / Q000009:adverse effects*; D006502:Budd-Chiari Syndrome / Q000139:chemically induced; D056486:Chemical and Drug Induced Liver Injury; D006801:Humans; D016030:Kidney Transplantation; D008099:Liver / Q000473:pathology; D008107:Liver Diseases / Q000473:pathology; D008297:Male; D008875:Middle Aged; D014184:Transplantation, Homologous
D001379:Azathioprine