[Prevention of microaggregation in stored blood (author's transl)].
Microembolism is still a feared complication during and after blood transfusions. Up to now they could only be diminished by special filter systems. In spite of much research it has not been possible as yet to fine adequate remedies for the preservation of blood cells and for the decrease of aggregation in stored blood. As foregoing studies have shown the inhibition of aggregation is combined with a considerable impairment or even loss of platelet function. In these clinical experiments, however, it has been shown, that aggregations in stored blood are significantly stunted by early addition of Aprotinin. It is clinically important, that no inhibition of platelet function occured.
D007611:Aprotinin / Q000494:pharmacology; D001792:Blood Platelets / Q000187:drug effects; D001793:Blood Preservation; D004617:Embolism / Q000517:prevention & control; D006801:Humans; D010974:Platelet Aggregation / Q000187:drug effects; D065227:Transfusion Reaction
D007611:Aprotinin
Beeinflussung der Mikroaggregation in lagernden Blutkonserven