Evidence for the activation of 3-methylcholanthrene as a carcinogen in vivo and asa mutagen in vitro by P1 -450 from inbred strains of mice.
Genetic differences in aromatic hydrocarbon "responsiveness" exist among various mouse strains. New formation of cytochrome P1-450 and the induction aryl hydrocarbon (benzo [a ])pyrene) hydroxylase (as well as numerous other monooxygenase activities) appear to be associated ultimately with genes that cosegregate at a small number of genetic loci. By comparing "responsive" and "nonresponsive" siblings, we can evaluate the susceptibility of each individual to various mutagenic chemicals in vitro or carcinogenic agents in vivo.
D000818:Animals; D002273:Carcinogens / Q000378:metabolism*; D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism*; D005419:Flavonoids / Q000494:pharmacology; D005838:Genotype; D008099:Liver / Q000201:enzymology; D008748:Methylcholanthrene / Q000378:metabolism* / Q000494:pharmacology; D051379:Mice; D008806:Mice, Inbred AKR; D008809:Mice, Inbred C3H; D008810:Mice, Inbred C57BL; D008811:Mice, Inbred DBA; D008826:Microbial Sensitivity Tests; D006899:Mixed Function Oxygenases / Q000032:analysis; D008954:Models, Biological; D008967:Molecular Biology; D009153:Mutagens / Q000378:metabolism*; D009281:Naphthalenes / Q000494:pharmacology; D010105:Oxygenases / Q000032:analysis; D010634:Phenobarbital / Q000494:pharmacology; D011083:Polycyclic Compounds / Q000378:metabolism; D012486:Salmonella typhimurium / Q000187:drug effects
D002273:Carcinogens; D005419:Flavonoids; D009153:Mutagens; D009281:Naphthalenes; D011083:Polycyclic Compounds; D008748:Methylcholanthrene; D003577:Cytochrome P-450 Enzyme System; D006899:Mixed Function Oxygenases; D010105:Oxygenases; D010634:Phenobarbital