Effects of 13-nle-motilin in man--inhibition of gastric evacuation and stimulation of pepsin secretion.
In 3 healthy male volunteers, graded doses of 13-norleucine-motilin (13-nle-motilin)--synthetic analogue of motilin and biologically equivalent to the natural polypeptide--were given intravenously on separate days. Gastric emptying, as determined by means of a radioisotope method, was slowed down dose-dependently by increasing doses of 13-nle-motilin. This was indicated by increasing "half-lives" and "starting indices" of the gastric emptying process, and by decreasing pyloric loss rates, respectively. The gastric pepsin output rose markedly from the basal level during intravenous infusion of 13-nle-motilin.
D000328:Adult; D003864:Depression, Chemical; D004305:Dose-Response Relationship, Drug; D005768:Gastrointestinal Hormones / Q000008:administration & dosage / Q000494:pharmacology; D005769:Gastrointestinal Motility / Q000187:drug effects*; D006801:Humans; D007275:Injections, Intravenous; D008297:Male; D009037:Motilin / Q000031:analogs & derivatives; D009646:Norleucine / Q000008:administration & dosage / Q000031:analogs & derivatives / Q000494:pharmacology; D010434:Pepsin A / Q000378:metabolism*; D010455:Peptides / Q000494:pharmacology*; D012636:Secretory Rate / Q000187:drug effects; D013268:Stimulation, Chemical; D013997:Time Factors
D005768:Gastrointestinal Hormones; D010455:Peptides; D009037:Motilin; C008680:motilin, Nle(13)-; D009646:Norleucine; D010434:Pepsin A