Prolongation of pancreatic allograft survival by 5-fluorouracil.
Recipient survival in canine pancreatic allotransplantation was significantly prolonged when animals were treated with 5-fluorouracil in combination with low-dose azathioprine. Untreated dogs and those receiving only azathioprine survived for only short periods of time, and pancreatitis was frequently encountered. In contrast, animals treated with 5-fluorouracil were protected from pancreatitis and survived an average of almost three weeks.
D000818:Animals; D001379:Azathioprine / Q000276:immunology / Q000627:therapeutic use; D004285:Dogs; D005472:Fluorouracil / Q000276:immunology / Q000627:therapeutic use*; D006084:Graft Rejection; D006801:Humans; D007165:Immunosuppression Therapy; D010179:Pancreas / Q000473:pathology; D016035:Pancreas Transplantation; D010195:Pancreatitis / Q000517:prevention & control; D014184:Transplantation, Homologous
D001379:Azathioprine; D005472:Fluorouracil