Increased proliferation of T lymphocytes in the blood of patients with Hodgkin's disease.
We investigated the number of DNA-synthesizing T lymphocytes in the blood of patients with Hodgkin's disease, with infectious mononucleosis and in normal controls. T cells were characterized by their ability to form rosettes with unsensitized neuramidase-treated sheep red blood cells. Cells in DNA synthesis were evaluated autoradiographically after in vitro incubation with [3H]thymidine. Our results indicated a preferential proliferation of T lymphocytes in the blood of patients with Hodgkin's disease and infectious mononucleosis and suggested an increased turnover of these cells.
D000328:Adult; D000368:Aged; D002455:Cell Division; D005260:Female; D006689:Hodgkin Disease / Q000097:blood* / Q000503:physiopathology; D006801:Humans; D007244:Infectious Mononucleosis / Q000097:blood / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D013601:T-Lymphocytes / Q000503:physiopathology*