Althesin and thiopentone: a clinical comparison.
Althesin was compared with thiopentone in a double blind study of 200 patients undergoing gynaecological operations. Althesin in a dose of 0.05 ml/kg was found to be an excellent induction agent, virtually devoid of undesirable side effects; however, when used as the principal anaesthetic (supplemented only by 66 per cent nitrous oxide in oxygen), the incidence of disturbing movements was high. Recovery time from Althesin was one-third of that after thiopentone. The patients recovering from Althesin were remarkably clearheaded with a low incidence of "hangover".
D000328:Adult; D000530:Alfaxalone Alfadolone Mixture / Q000008:administration & dosage / Q000009:adverse effects / Q000494:pharmacology*; D000771:Anesthesia, Intravenous; D001794:Blood Pressure / Q000187:drug effects; D002986:Clinical Trials as Topic; D004305:Dose-Response Relationship, Drug; D004341:Drug Evaluation; D005260:Female; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D011277:Pregnanediones / Q000494:pharmacology*; D012119:Respiration / Q000187:drug effects; D013874:Thiopental / Q000008:administration & dosage / Q000009:adverse effects / Q000494:pharmacology*
D011277:Pregnanediones; D000530:Alfaxalone Alfadolone Mixture; D013874:Thiopental