Effect of long-term hyperglucocorticoidism on the neuronal morphology of the trigeminal ganglion of the mouse.
Immature mice were treated for up to 12 weeks with daily doses of triamcinolone diacetate. The trigeminal ganglion was studied histologically at regular intervals. By the tenth injection significant morphological changes were noted in the various nerve cells, followed by marked cellular deterioration in the form of lysis or pyknosis. A possible explanation for the above findings is discussed.
D000818:Animals; D005260:Female; D005938:Glucocorticoids / Q000494:pharmacology*; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D013997:Time Factors; D014221:Triamcinolone / Q000008:administration & dosage / Q000494:pharmacology; D012668:Trigeminal Ganglion / Q000033:anatomy & histology / Q000166:cytology / Q000187:drug effects*; D014276:Trigeminal Nerve / Q000187:drug effects*
D005938:Glucocorticoids; D014221:Triamcinolone