[Investigations on the effectiveness of a new antimycotic through experimental keratomycosis in rabbits (author's transl)].
Thirty-two rabbits infected with Fumigatus keratitis were treated for a period of  10 to 20 days with a new antifungal agent known as "BAY b 5097" (Canesten). It was administered to 6 animals (500 mg/kg body weight; 12 eyes) orally; 20 received unilateral topical treatment. In both groups the therapy failed to supress mycosis in the avascular cornea. In topical treatment problems concerning common solvents arise: They are unable to reach the intracorneal infection, and most of them are incompatible for conjunctival use.
D000284:Administration, Oral; D000287:Administration, Topical; D000818:Animals; D000935:Antifungal Agents / Q000627:therapeutic use*; D001555:Benzene Derivatives / Q000627:therapeutic use; D002177:Candidiasis / Q000188:drug therapy*; D007093:Imidazoles / Q000627:therapeutic use*; D007634:Keratitis / Q000188:drug therapy*; D011817:Rabbits
D000935:Antifungal Agents; D001555:Benzene Derivatives; D007093:Imidazoles
Untersuchungen zur Frage der Wirksamkeit eines neuen Antimycoticums bei experimenteller Keratomycose an Kaninchen