Screening for cystic fibrosis by analysis of serum protein in faeces.
Faecal specimens from 51 infants free of cystic fibrosis (CF) and from 9 infants with the disease were analysed for albumin and alpha1-antitrypsin content. Faeces from infants with no CF had a mean albumin content of less than 0-1 mg/g dry weight and a mean albumin: alpha1-antitrypsin ratio value of less than 0-1. Faeces from infants with CF had, with one exception, an albumin content of more than 2-0 mg/g dry weight and a ratio value greater than 3-0. It was subsequently found that the duodenal aspirate from the child with CF but whose faeces had a low albumin content and ratio value, had tryptic activity though at a much reduced level compared to the activity in aspirates from healthy infants.
D000418:Albumins / Q000032:analysis*; D003550:Cystic Fibrosis / Q000175:diagnosis*; D005243:Feces / Q000032:analysis*; D006801:Humans; D008470:Meconium / Q000032:analysis; D000515:alpha 1-Antitrypsin / Q000032:analysis*
D000418:Albumins; D000515:alpha 1-Antitrypsin