Antigen-specific T-cell factor in cell cooperation. Mapping within the I region of the H-2 complex and ability to cooperate across allogeneic barriers.
Further mapping of the mouse T-cell factor specific for poly(Try,Glu)-polyD-LAla--polyLys is reported. It is shown to be a product of the I-A subregion of the H-2 complex by the use of antisera either raised specifically against or made specific, by absorption, for different regions of the H-2 complex. The factor cooperates across allogeneic barriers, e.g., when factor produced by one strian is combined with bone marrow cells of other H-2 incompatible strains.
D000818:Animals; D000917:Antibody Formation; D000941:Antigens; D001854:Bone Marrow Cells; D016026:Bone Marrow Transplantation; D002874:Chromosome Mapping; D003433:Crosses, Genetic; D005260:Female; D005796:Genes; D006649:Histocompatibility Antigens; D008198:Lymph Nodes / Q000637:transplantation; D008297:Male; D051379:Mice; D010455:Peptides / Q000276:immunology; D016038:Skin Transplantation; D013154:Spleen / Q000637:transplantation; D013601:T-Lymphocytes / Q000276:immunology*; D013950:Thymus Gland / Q000637:transplantation; D013997:Time Factors; D014184:Transplantation, Homologous
D000941:Antigens; D006649:Histocompatibility Antigens; D010455:Peptides