Bronchopulmonary dysplasia and lung rupture in hyaline membrane disease: influence of continuous distending pressure.
Review of 158 patients with hyaline membrane disease was undertaken. The introduction of artificial ventilation with a positive end-expiratory pressure (IPPB and PEEP) has doubled the prevalence of pneumothorax, pneumomediastinum and interstitial emphysema from 20.7% to 39.7%). Continuous negative distending pressure during spontaneous ventilation (CNP) was associated with a prevalence of lung rupture similar to that occurring spontaneously (4.8%). No patient treated with CNP alone developed bronchopulmonary dysplasia. Patients treated with IPPB with PEEP had a marked decreased prevalence of bronchopulmonary dysplasia (17.2%) when compared to patients treated with IPPB alone (36.2%), probably related to the enhanced overdistension of relatively normal areas of the lung may be related to the increased prevalence of lung rupture seen during IPPB with PEEP.
D006801:Humans; D006819:Hyaline Membrane Disease / Q000628:therapy*; D007231:Infant, Newborn; D008171:Lung Diseases / Q000000981:diagnostic imaging / Q000209:etiology* / Q000401:mortality; D008478:Mediastinal Emphysema / Q000209:etiology*; D010100:Oxygen / Q000633:toxicity*; D011030:Pneumothorax / Q000209:etiology*; D011175:Positive-Pressure Respiration / Q000009:adverse effects*; D011859:Radiography; D012421:Rupture; D013997:Time Factors
D010100:Oxygen