Interstital nephritis in autoimmune hemolytic anemia.
A case is reported of a 15-year-old boy with chronic autoimmune hemolytic anemia who developed renal insufficiency 3 years after splenectomy. An interstitial nephritis with striking lymphocytic infiltrates and sclerosed glomeruli could be demonstrated by percutaneous renal biopsy. Renal symptoms disappeared promptly after corticosteroid therapy. The renal lesions are thought to have arisen as part of the autoimmune disease.
D000293:Adolescent; D000305:Adrenal Cortex Hormones / Q000627:therapeutic use; D000744:Anemia, Hemolytic, Autoimmune / Q000150:complications* / Q000276:immunology; D003404:Creatinine / Q000097:blood; D006801:Humans; D007668:Kidney / Q000473:pathology; D007678:Kidney Glomerulus / Q000473:pathology; D008213:Lymphocyte Activation; D008233:Lymphotoxin-alpha; D008297:Male; D009395:Nephritis, Interstitial / Q000188:drug therapy / Q000209:etiology* / Q000473:pathology; D009929:Organ Size; D013156:Splenectomy
D000305:Adrenal Cortex Hormones; D008233:Lymphotoxin-alpha; D003404:Creatinine