Cyclophosphamide-induced immunological tolerance: recovery leads to a memory state.
Tolerance to SRBC has been induced in adult mice by the aid of cyclophosphamide, and the duration of the tolerant state has been tested by a second injection of antigen at different times thereafter. As evidenced by 19S and 7S PFC 4 days after challenge, tolerance in this model is of relatively short duration and leads spontaneously to a memory state.
D000818:Animals; D003520:Cyclophosphamide / Q000494:pharmacology*; D004912:Erythrocytes / Q000276:immunology; D006462:Hemolytic Plaque Technique; D007108:Immune Tolerance / Q000187:drug effects*; D007156:Immunologic Memory / Q000187:drug effects*; D051379:Mice
D003520:Cyclophosphamide