title: Trimethorpim-sulfamethoxazole in the treatment of chronic prostatitis.
abstract: Chronic prostatis is a common condition for which evidence of bacterial etiology is often lacking, possibly because of difficulty in obtaining secretion from the diseased portion of the gland. Aids to diagnosis apart from bacteriologic studies are of little value. It has been shown that trimethoprim reaches high levels in the prostatic fluid and when combined with sulfamethoxazole provides a highly effective antibacterial agent. In a survey of 40 patients with chronic prostatitis treated with TMP-SMX the usefulness of the combination was demonstrated.
mesh_terms: D000284:Administration, Oral; D001424:Bacterial Infections / Q000175:diagnosis / Q000188:drug therapy*; D001431:Bacteriological Techniques; D001437:Bacteriuria / Q000175:diagnosis; D001707:Biopsy, Needle; D003558:Cystoscopy; D004338:Drug Combinations; D004341:Drug Evaluation; D004357:Drug Synergism; D006801:Humans; D008297:Male; D011467:Prostate / Q000378:metabolism; D011472:Prostatitis / Q000175:diagnosis / Q000188:drug therapy*; D013420:Sulfamethoxazole / Q000008:administration & dosage / Q000627:therapeutic use*; D014295:Trimethoprim / Q000008:administration & dosage / Q000378:metabolism / Q000627:therapeutic use*; D014552:Urinary Tract Infections / Q000175:diagnosis
chemical_list: D004338:Drug Combinations; D014295:Trimethoprim; D013420:Sulfamethoxazole