title: Massive colonic bleeding and oral contraceptive "pills".
abstract: Two patients on oral contraceptives who developed massive colonic bleeding have been presented. The clinical course and various studies suggest the mesenteric insufficiency syndrome as being a possible result of oral contraceptive effect on mesenteric vasculature. Although no definite histologic confirmation is available, the onset, course, and follow-up of these patients suggest contraceptive-induced massive colonic bleeding. The spectrum of oral contraceptive-induced colonic bleeding may vary from mucosal injury with massive colonic bleeding to transmural infarction. Only the clinical follow-up would determine the severity of the involvement and that would determine whether surgical intervention  will be necessary.
mesh_terms: D000328:Adult; D003108:Colonic Diseases / Q000139:chemically induced*; D003276:Contraceptives, Oral / Q000009:adverse effects*; D005260:Female; D006471:Gastrointestinal Hemorrhage / Q000139:chemically induced*; D006801:Humans; D008641:Mesenteric Vascular Occlusion / Q000139:chemically induced; D008875:Middle Aged; D011247:Pregnancy; D013927:Thrombosis / Q000139:chemically induced
chemical_list: D003276:Contraceptives, Oral