Helper T-cell kinetics and investigation of antigen receptor expression on early and memory T-helper cells.
The subcutaneous application of soluble antigen resulted in generation of helper T lymphocytes in the draining lymph nodes, tested 4 days after priming in the adoptive transfer system. Four days later a specific helper T-cell population was detected in the spleen. B-cell activity could be demonstrated 4-5 days after helper T-cell activity in both organs. We investigated the early helper T-cell population and memory T cells with respect to differences in the expression of antigen receptors. No such differences could be detected, either by anti-immunoglobulin-coated Degalan columns or by an antigen-specific rosetting method.
D000818:Animals; D000921:Antibody-Producing Cells; D000941:Antigens; D001402:B-Lymphocytes / Q000276:immunology; D001666:Binding Sites, Antibody; D005260:Female; D007114:Immunization; D007156:Immunologic Memory; D007700:Kinetics; D007958:Leukocyte Count; D008297:Male; D051379:Mice; D008808:Mice, Inbred CBA; D010047:Ovalbumin / Q000276:immunology; D011947:Receptors, Antigen, B-Cell; D012710:Serum Albumin, Bovine / Q000276:immunology; D013601:T-Lymphocytes / Q000276:immunology*
D000941:Antigens; D011947:Receptors, Antigen, B-Cell; D012710:Serum Albumin, Bovine; D010047:Ovalbumin