Varicella followed by glomerulonephritis. Treatment with corticosteroids and azathioprine resulting in recurrence of varicella.
The present report outlines the clinical features of a 2-year-old boy who following varicella developed purpura of the lower extremities, transient gastrointestinal bleeding and glomerulonephritis. The triad of symptoms suggests Schonlein-Henoch Syndrome, but coagulation studies and renal biopsy did not confirm this, and varicella is thought to be the cause of the complications. Therapy with corticosteroids and azathioprine had only a minor effect on the nephritis but caused depression of serum IgG and specific antibody resulting in reinfection or reactivation of varicella.
D001379:Azathioprine / Q000009:adverse effects* / Q000627:therapeutic use; D002644:Chickenpox / Q000150:complications* / Q000276:immunology; D002675:Child, Preschool; D005076:Exanthema / Q000209:etiology; D006471:Gastrointestinal Hemorrhage / Q000209:etiology; D005921:Glomerulonephritis / Q000209:etiology*; D006801:Humans; D008297:Male; D011241:Prednisone / Q000009:adverse effects* / Q000627:therapeutic use; D012008:Recurrence
D001379:Azathioprine; D011241:Prednisone