Quantal release parameters during fade of endplate potentials.
An analog of hemicholinium-3 caused the fade of endplate potentials during repetitive stimulation at low rates. The quantal parameters of release were estimated during steady-state conditions before and in the presence of the drug. The fade of EPP's was associated with a decrease in quantal content (m). The decrease in m was, in turn, associated with a decrease in the binomial parameter n and an increase in the binomial parameter p. The changes in n and p are discussed in relation to available stores of transmitter and the probability of transmitter release.
D000200:Action Potentials / Q000187:drug effects; D000818:Animals; D001001:Anura; D004558:Electric Stimulation; D066298:In Vitro Techniques; D009045:Motor Endplate / Q000502:physiology*; D009132:Muscles / Q000187:drug effects; D009469:Neuromuscular Junction / Q000502:physiology*; D000644:Quaternary Ammonium Compounds / Q000494:pharmacology; D011894:Rana pipiens; D012584:Sciatic Nerve / Q000502:physiology
D000644:Quaternary Ammonium Compounds