title: [Tetanic fatigue and proximate post-tetanic recuperation in sartorius and flexor carpi radialis muscles of the male frog. Effects of iodoacetic acid (author's transl)].
abstract: The time-course of the isometric tension output, at 20 degrees C, during a long tetanus and after a short period of rest, was investigated in two isolated frog muscles : the sartorius and flexor carpi radialis muscles. To prevent aerobie and glycolytic recovery processes, some muscles were poisoned with 0,4 mM iodoacetic acid (IAA) and nitrogen, for 20 or 40 min. 1. For the unpoisoned sartorius muscle, tetanic tension declined quickly, but after a 0,8 sec period of rest, the muscle was able to develop high tension. Poisoning with IAA-N2 increased fatigue without suppressing the property of a proximate post-tetanic recuperation. 2. In the flexor carpi radialis muscle resistance to fatigue was very large before poisoning and diminished after poisoning. Proximate recuperation was very weak. 3. The results show that the recovery processes are not a primary factor of the development of the short-term fatigue ; they enhance the hypothesis that a failure of the electromechanical coupling can explain the rate of the tension fall in tetanized sartorius muscles.
mesh_terms: D000693:Anaerobiosis; D000818:Animals; D004558:Electric Stimulation; D005121:Extremities; D005221:Fatigue; D007461:Iodoacetates / Q000494:pharmacology* / Q000506:poisoning; D008297:Male; D009119:Muscle Contraction; D009132:Muscles / Q000187:drug effects / Q000502:physiology*; D009584:Nitrogen; D011896:Rana temporaria; D013997:Time Factors
chemical_list: D007461:Iodoacetates; D009584:Nitrogen
vernacular_title: Fatigue tétanique et récupération post-tétanique immédiate dans les muscles sartorius et flexor carpi radialis de la grenouille mâle. Effets de l'acide iodoacétique