Effects of anti-Ia serum on mitogenic responses. I. Inhibition of the proliferative response to B cell mitogen, LPS, by specific anti-Ia sera.
Specific anti-Ia serum in combination with rabbit complement removed the B lymphocyte population normally responsive to LPS mitogenic stimulation. Significant inhibition of this proliferative response was also obtained by brief periods of cell pretreatment with anti-Ia antibodies, but not with specific anti-H-2K antibodies. The population of splenic B cells resistant to anti-Thy-1.2 serum and complement was blocked in a very similar manner by anti-Ia serum, but not by anti-H-2 serum.
D000818:Animals; D000918:Antibody Specificity; D001402:B-Lymphocytes / Q000276:immunology*; D001789:Blood Group Antigens; D006649:Histocompatibility Antigens; D007048:I Blood-Group System; D007518:Isoantibodies; D008070:Lipopolysaccharides; D008213:Lymphocyte Activation / Q000187:drug effects*; D051379:Mice; D008815:Mice, Inbred Strains; D008934:Mitogens; D013154:Spleen / Q000276:immunology
D001789:Blood Group Antigens; D006649:Histocompatibility Antigens; D007048:I Blood-Group System; D007518:Isoantibodies; D008070:Lipopolysaccharides; D008934:Mitogens