Automated assay of N-acetyl-beta-glucosaminidase in normal and pathological human urine.
An automated method for the assay of N-acetyl-beta-glucosaminidase in human urine is described and a normal range of urinary N-acetyl-beta-glucosaminidase activity is reported. The automated method has been used routinely over a twelve month period in two London hospitals for monitoring the excretion of N-acetyl-beta-glucosaminidase in renal transplant patients. The abnormal elevation of urinary N-acetyl-beta-glucosaminidase provides an early warning of rejection by indicating the presence of renal parenchymal damage. The automated assay of urinary N-acetyl-beta-glucosaminidase may also be used in screening for the presence of renal disease.
D000118:Acetylglucosaminidase / Q000652:urine*; D000293:Adolescent; D000328:Adult; D000368:Aged; D001322:Autoanalysis / Q000379:methods; D002648:Child; D003404:Creatinine / Q000652:urine; D006596:Hexosaminidases / Q000652:urine*; D006801:Humans; D007674:Kidney Diseases / Q000175:diagnosis / Q000652:urine; D016030:Kidney Transplantation; D008875:Middle Aged; D013997:Time Factors; D014184:Transplantation, Homologous
D003404:Creatinine; D006596:Hexosaminidases; D000118:Acetylglucosaminidase