title: Marijuana smoking and reduced pressure in human eyes: drug action or epiphenomenon?
abstract: Normal pressure within the human eye was reduced after smoking a socially relevant dose of marijuana (12 mg. delta9-9-tetrahydrocannabinol), but only for light to moderate users who experienced a substantial "high" and a state of peaceful relaxation from the experimental dose. Analysis suggests an indirect effect of the drug associated with relaxation-a psychophysiologic state that can be produced by drug and nondrug  means.
mesh_terms: D000293:Adolescent; D000328:Adult; D002188:Cannabis; D002707:Chlordiazepoxide / Q000627:therapeutic use; D002986:Clinical Trials as Topic; D013759:Dronabinol / Q000494:pharmacology* / Q000627:therapeutic use; D000431:Ethanol / Q000627:therapeutic use; D005901:Glaucoma / Q000188:drug therapy; D006801:Humans; D007429:Intraocular Pressure / Q000187:drug effects*; D008297:Male; D008517:Phytotherapy; D010919:Placebos; D011603:Psychophysiology; D012063:Relaxation; D019966:Substance-Related Disorders; D011795:Surveys and Questionnaires; D013997:Time Factors; D014065:Tonometry, Ocular
chemical_list: D010919:Placebos; D000431:Ethanol; D002707:Chlordiazepoxide; D013759:Dronabinol