[Allergen-induced bronchoconstriction in asthma: antagonistic effect of a synthetic anticholinergic drug (author's transl)].
In ten allergic patients, the effect of inhaltion of increasing quantities of grass pollen on specific airways resistance (SRaw, measured by plethysmography) was estimated after preliminary inhalation of a placebo and of a synthetic anticholinergic drug (SCH 10000). After placebo, the inhalation of grass pollen induced in all cases a bronchoconstriction (mean increase of SRaw : 170 %). After SCH 1000, and for the same quantity of pollen inhaled, seven patients were entirely protected against the bronchoconstrictor effect of the allergen ; for the whole group, the observed bronchoconstriction was significantly lower (p less than 0.01, mean increase of SRaw : 60 %). The possible mechanisms of this protection are discussed. The results suggest that SCH 1000 could be used as a preventive drug in pollinic asthma.
D000328:Adult; D000336:Aerosols; D000403:Airway Resistance; D001249:Asthma / Q000188:drug therapy* / Q000209:etiology; D001285:Atropine / Q000627:therapeutic use*; D001993:Bronchodilator Agents / Q000627:therapeutic use*; D002986:Clinical Trials as Topic; D004305:Dose-Response Relationship, Drug; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010276:Parasympatholytics / Q000627:therapeutic use*; D010919:Placebos; D006109:Poaceae; D011058:Pollen; D014326:Tropanes / Q000627:therapeutic use*
D000336:Aerosols; D001993:Bronchodilator Agents; D010276:Parasympatholytics; D010919:Placebos; D014326:Tropanes; D001285:Atropine
Bronchoconstriction provoquée par inhalation d'allergène dans l'asthme: effet antagoniste d'un anticholinergique de synthèse