title: Reticulosarcomatosis originating from skin--A clinicopathological study.
abstract: The case is that of a 65 year-old male with reticulosarcomatosis originating from the skin. There were multiple tumors composed of reticulum cells located only in the skin, particularly around the large joints. The entire course of illness was three years and five months, during which period regression by irradiation, recurrence, or new formation of tumors were repeatedly seen. At the end systemic tumor spread not only of the skin but also in various visceral organs including lymph nodes occurred. From histological and electron microscopic examinations repeatedly performed with biopsy materials, and finally with autopsy materials it was ascertained that the tumor cells had become smaller in size with less lymphoid cell infiltration at the terminal stage.
mesh_terms: D000368:Aged; D002466:Cell Nucleolus / Q000648:ultrastructure; D002467:Cell Nucleus / Q000648:ultrastructure; D003593:Cytoplasm / Q000648:ultrastructure; D004721:Endoplasmic Reticulum / Q000648:ultrastructure; D006056:Golgi Apparatus / Q000648:ultrastructure; D006801:Humans; D016403:Lymphoma, Large B-Cell, Diffuse / Q000473:pathology*; D008297:Male; D008928:Mitochondria / Q000648:ultrastructure; D012270:Ribosomes / Q000648:ultrastructure; D012867:Skin / Q000473:pathology* / Q000648:ultrastructure; D012878:Skin Neoplasms / Q000473:pathology*