Methotrexate megadosage followed by folate rescue. I. A study in clearance patterns.
Plasma clearance rates of methotrexate  (MTX) have been determined in five patients given an infusion of 3,000 mg of MTX over six hours, followed by folate rescue 24 hours after the commencement of infusion. Results presented indicate that maintenance of high MTX concentrations and potential toxicity could not be related to age, body weight or surface area.
D000293:Adolescent; D000328:Adult; D002648:Child; D005260:Female; D006801:Humans; D002955:Leucovorin / Q000627:therapeutic use*; D008297:Male; D008657:Metabolic Clearance Rate; D008727:Methotrexate / Q000097:blood* / Q000627:therapeutic use / Q000652:urine; D008875:Middle Aged; D012516:Osteosarcoma / Q000097:blood* / Q000188:drug therapy / Q000652:urine
D002955:Leucovorin; D008727:Methotrexate