Inhibitory effect of Apernyl on production of bradykininlike substance in pulp.
In the Formalin-induced pulpitis of rats and the electrically stimulated pulps of dogs, a bradykininlike substance developed by the pulps and released into a saline pool on the exposed pulps disappeared after a local application of Apernyl solution. This suggests that the possible pain-reducing or anti-in-flammatory effect of Apernyl is a result of its inhibiting bradykinin production.
D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology*; D001241:Aspirin / Q000494:pharmacology*; D001681:Biological Assay; D001920:Bradykinin / Q000032:analysis / Q000378:metabolism*; D003782:Dental Pulp / Q000187:drug effects / Q000378:metabolism*; D003789:Dental Pulp Exposure; D003864:Depression, Chemical; D004285:Dogs; D004338:Drug Combinations; D004558:Electric Stimulation; D005557:Formaldehyde / Q000009:adverse effects; D008297:Male; D010226:Parabens / Q000494:pharmacology*; D011671:Pulpitis / Q000139:chemically induced / Q000378:metabolism; D051381:Rats
D000894:Anti-Inflammatory Agents, Non-Steroidal; D004338:Drug Combinations; D010226:Parabens; D005557:Formaldehyde; D001241:Aspirin; D001920:Bradykinin