The effect of local anesthetic solutions on the blood vessels of the rat molars.
The effect of solutions of lidocaine, with and without adrenaline, on the blood vessels of the dental pulp and periodontal ligament in rat molars was examined. The vessels were visualized by intravascular injection of a supension of carbon particles. The results indicate that the anesthetic solution alone does have a local effect on the blood vessels. Local anesthetic solutions containing adrenaline had a more marked effect; in addition, a dose-dependent systemic effect of adrenaline was noted.
D000818:Animals; D001808:Blood Vessels / Q000187:drug effects*; D003782:Dental Pulp / Q000098:blood supply* / Q000187:drug effects; D004837:Epinephrine / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D008012:Lidocaine / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D008297:Male; D008963:Molar / Q000098:blood supply; D010513:Periodontal Ligament / Q000098:blood supply*; D051381:Rats
D008012:Lidocaine; D004837:Epinephrine