title: Promotion of secondary anti-DNP antibody production in mice by type III pneumococcal polysaccharide (SIII) and dinitrophenylated rabbit antibody to SIII.
abstract: Type III pneumococcal polysaccharide (SIII) is able markedly to increase the adoptive IgG ANTI-DNP antibody response of B cells primed to DNP-flagellin and stimulated with DNP conjugated to the heterologous carrier, rabbit globulin, provided the latter has anti-SIII activity. The stimulatory effect is apparently accessory cell-dependent as well as being unequivocally T cell-dependent. Although no positive evidence is available, the possibility exists that non-specific T-cell activation is involved in the stimulating effect of anti-SIII plus SIII.
mesh_terms: D000818:Animals; D000917:Antibody Formation; D000921:Antibody-Producing Cells; D000936:Antigen-Antibody Complex; D001402:B-Lymphocytes / Q000276:immunology; D002678:Chimera; D005260:Female; D006462:Hemolytic Plaque Technique; D006736:Horses / Q000276:immunology; D007108:Immune Tolerance; D007074:Immunoglobulin G; D008297:Male; D051379:Mice; D008808:Mice, Inbred CBA; D009578:Nitrobenzenes / Q000276:immunology*; D011135:Polysaccharides, Bacterial / Q000276:immunology*; D011817:Rabbits / Q000276:immunology; D011827:Radiation; D012756:Sheep / Q000276:immunology; D013154:Spleen / Q000276:immunology; D013601:T-Lymphocytes / Q000276:immunology
chemical_list: D000936:Antigen-Antibody Complex; D007074:Immunoglobulin G; D009578:Nitrobenzenes; D011135:Polysaccharides, Bacterial