title: A method for prevention of cardiovascular reactions to laryngoscopy and intubation.
abstract: A technique of nebulizing lidocaine in the upper airways was developed and its effectiveness in preventing cardiovascular responses to laryngoscopy and intubation was documented. In ten pre-treated patients the average percentage-rise in systolic blood pressure was 10.3 per cent and there were no arrhythmias. The pulse rate increased by 16.8 per cent. In ten control patients, the systolic blood pressure increased by 56 per cent and the incidence of arrhythmias was 40 per cent. The pulse rate increased by 38.8 per cent. The significance and application of these results is discussed and compared to other available methods. The opinion is expressed that the effect of the aerosol, especially as it relates to the suppression of arrhythmias, is partly due to systemic absorption of lidocaine.
mesh_terms: D000336:Aerosols; D000368:Aged; D001145:Arrhythmias, Cardiac / Q000209:etiology / Q000517:prevention & control*; D001794:Blood Pressure; D002245:Carbon Dioxide / Q000097:blood; D002986:Clinical Trials as Topic; D004562:Electrocardiography; D006221:Halothane; D006801:Humans; D006973:Hypertension / Q000209:etiology / Q000517:prevention & control*; D007442:Intubation, Intratracheal / Q000009:adverse effects*; D007828:Laryngoscopy / Q000009:adverse effects*; D008012:Lidocaine / Q000008:administration & dosage* / Q000097:blood / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged; D009609:Nitrous Oxide; D010100:Oxygen / Q000097:blood; D011188:Potassium / Q000097:blood; D011674:Pulse; D013874:Thiopental
chemical_list: D000336:Aerosols; D002245:Carbon Dioxide; D008012:Lidocaine; D013874:Thiopental; D009609:Nitrous Oxide; D011188:Potassium; D010100:Oxygen; D006221:Halothane