title: H-2-linked genetic control of antibody response to soluble calf skin collagen in mice.
abstract: An autosomal dominant immune response gene could be demonstrated in congenic resistant strains of mice which is linked to the H-2 locus and controls the antibody response to soluble calf collagen. High responsiveness was associated with the H-2 alleles, b and f, low responsiveness with the H-2 alleles, d, k, m and r. Studies with calf procollagen, which contains an additional carrier moiety, indicated that these genetic differences might be expressed at the level of T cells.
mesh_terms: D000818:Animals; D000917:Antibody Formation; D003094:Collagen / Q000276:immunology*; D005260:Female; D005796:Genes; D005799:Genes, Dominant; D008040:Genetic Linkage; D006649:Histocompatibility Antigens; D008297:Male; D051379:Mice; D011347:Procollagen / Q000276:immunology; D013601:T-Lymphocytes / Q000276:immunology*
chemical_list: D006649:Histocompatibility Antigens; D011347:Procollagen; D003094:Collagen