Antibacterial activity of delta9-tetrahydrocannabinol and cannabidiol.
The minimum inhibiting concentrations (MIC) of delta9-tetrahydrocannabinol (THC) and cannabidiol (CBD) for staphylococci and streptococci in broth are in the range of 1-5 mug/ml. In the same range, both compounds are also bactericidal. In media containing 4% serum or 5% blood the antibacterial activity is strongly reduced (MIC 50 mug/ml). Gram-negative bacteria are resistant to THC and CBD.
D002185:Cannabidiol / Q000494:pharmacology*; D002188:Cannabis / Q000494:pharmacology*; D002455:Cell Division / Q000187:drug effects; D013759:Dronabinol / Q000494:pharmacology*; D004755:Enterobacteriaceae / Q000187:drug effects; D013045:Species Specificity; D013210:Staphylococcus / Q000187:drug effects*; D013291:Streptococcus / Q000187:drug effects*
D002185:Cannabidiol; D013759:Dronabinol