Effect of Nocardia and Mycobacterium cell-wall skeleton on autochthonous tumor grafts.
Cell-wall skeleton of Nocardia rubra and of Mycobacterium bovis BCG in the oil-attached form, when injected mixes with autografts of spontaneous mammary adenocarcinoma or of methylcholanthrene-induced sarcoma of mice, suppresses the growth of tumor autografts to a demonstrate extent. The BCG whole cell wall showed no effect. The local destruction of tumor autografts did not induce recognizable systemic immunity to the respective tumors. These findings are commended upon from immunological and chemical points of view.
D000230:Adenocarcinoma / Q000276:immunology*; D000818:Animals; D002473:Cell Wall / Q000276:immunology*; D007165:Immunosuppression Therapy; D008325:Mammary Neoplasms, Experimental / Q000276:immunology*; D008748:Methylcholanthrene; D051379:Mice; D009163:Mycobacterium bovis / Q000276:immunology* / Q000648:ultrastructure; D009368:Neoplasm Transplantation; D009615:Nocardia / Q000276:immunology* / Q000648:ultrastructure; D012513:Sarcoma, Experimental / Q000139:chemically induced / Q000276:immunology*; D014182:Transplantation, Autologous
D008748:Methylcholanthrene