Retinal pigment epithelial degeneration, partial retinal atrophy and macular hole in acute lymphocytic leukemia.
A seven year old child with acute lymphocytic leukemia presented at autopsy with a macular hole, and degeneration of the retinal pigment epithelium and its overlying photoreceptors. She had been treated with cobalt 60, methotrexate, vincristine cyclophosphamide and prednisone. A review of the literature of similar findings as well as pigment epithelial degenerations from other causes is presented.
D000970:Antineoplastic Agents / Q000627:therapeutic use; D001284:Atrophy; D002648:Child; D002829:Choroid / Q000473:pathology; D004848:Epithelium; D005260:Female; D006801:Humans; D007945:Leukemia, Lymphoid / Q000150:complications* / Q000188:drug therapy; D008268:Macular Degeneration / Q000209:etiology; D009900:Optic Nerve / Q000473:pathology; D010786:Photoreceptor Cells; D012162:Retinal Degeneration / Q000209:etiology*; D012168:Retinal Pigments; D012171:Retinal Vessels / Q000473:pathology
D000970:Antineoplastic Agents; D012168:Retinal Pigments