[Transport of 131J-iodo-o-hippurate and 22Na out of the retroretinal space in experimental non rhegmatogenous detachment of the retina (author's transl)].
A model of an experimental arhegmatogenous retinal detachment is presented, to allow the measurement of the transport of radioactive labeled substances out of the subretinal space. Experiments were performed on 19 male cats. 131I-iodo-o-hippurate and 22Na were used as test substances. There was no significant difference between the rate of disappearance of 131I-hippurate  if injected retroretinally or intravitreally. The rate of disappearance of 131I-hippurate could be slowed down by intravenous infusion of penicillin-G. The rate of disappearance  of 22Na following retroretinal injection is not only slower than the rate of disappearance of 22Na injected intravitreally, but significantly slower than the rate of disappearance of 131I-hippurate. For graphic analysis ("curve peeling") of the terms embodied in the curves, more densly situated points of measurements will be necessary. Then the experimental model will serve well to analyze the components influencing the transport of labeled sodium out of the  subretinal space.
D000818:Animals; D001692:Biological Transport; D002415:Cats; D004195:Disease Models, Animal; D007267:Injections / Q000379:methods; D007457:Iodine Radioisotopes; D007465:Iodohippuric Acid / Q000008:administration & dosage / Q000378:metabolism*; D008297:Male; D008657:Metabolic Clearance Rate / Q000187:drug effects; D010400:Penicillin G / Q000494:pharmacology; D012163:Retinal Detachment / Q000209:etiology / Q000378:metabolism*; D012965:Sodium Chloride / Q000008:administration & dosage / Q000378:metabolism*; D012979:Sodium Radioisotopes; D014822:Vitreous Body / Q000378:metabolism
D007457:Iodine Radioisotopes; D012979:Sodium Radioisotopes; D007465:Iodohippuric Acid; D012965:Sodium Chloride; D010400:Penicillin G
Abtransport von 131qhippursäure und 22Na aus dem Retroretinal-Raum bei experimenteller arhegmatogener Netzhautablösung