Anti-tumour and anti-metastatic activity of 3-(P-Chlorophenyl)-2,3-Dihydro-3-Hydroxythiazolo (3,2-A)-Benzimidazole-2-acetic acid (WY-13,876).
Extensive investigation of 3-(p-chlorophenyl)-2,3-dihydro-3-hydroxythiazolo(3,2-alpha)-benzimidazole-2-acetic acid (Wy-13,876) in BDF1 mice implanted with Lewis lung tumour has shown that it is an effective anti-tumour and anti-metastatic agent. In vitro examination using HEp-2 human epidermal tumour cells has indicated that Wy-13,876 is not cytotoxic. When mice implanted with Lewis lung tumour and treated with Wy-13,876 are also injected with anti-thymocyte serum, an increase in lung metastases is observed suggesting that thymocyte activity is involved in the drug's mechanism of action. An increase in peripheral T lymphocytes observed in rats 18 h after a single oral dose of Wy-13,876 further supports this possibility. When Wy-13,876 is given to tumour -bearing mice in combination with low, ineffective doses of 5-fluorouracil or cyclophosphamide, further reduction of primary tumour growth is observed.
D000818:Animals; D000871:Anthelmintics / Q000627:therapeutic use / Q000633:toxicity; D000961:Antilymphocyte Serum; D000970:Antineoplastic Agents / Q000627:therapeutic use* / Q000633:toxicity; D001562:Benzimidazoles / Q000627:therapeutic use* / Q000633:toxicity; D003520:Cyclophosphamide / Q000627:therapeutic use; D005472:Fluorouracil / Q000627:therapeutic use; D007928:Lethal Dose 50; D007978:Levamisole / Q000627:therapeutic use; D008175:Lung Neoplasms / Q000188:drug therapy* / Q000276:immunology; D008297:Male; D051379:Mice; D009362:Neoplasm Metastasis / Q000188:drug therapy*; D009368:Neoplasm Transplantation; D009374:Neoplasms, Experimental / Q000188:drug therapy / Q000276:immunology; D013601:T-Lymphocytes / Q000276:immunology; D013844:Thiazoles / Q000627:therapeutic use / Q000633:toxicity; D014185:Transplantation, Isogeneic
D000871:Anthelmintics; D000961:Antilymphocyte Serum; D000970:Antineoplastic Agents; D001562:Benzimidazoles; D013844:Thiazoles; D007978:Levamisole; D003520:Cyclophosphamide; D005472:Fluorouracil