[Research in antitumoral chemotherapy. X. Cytotoxic and antitumoral activity of beta-nitrostyrenes and of composed nitrovinyl derivatives].
In previous work the antitumoral cytotoxicity of beta-nitrostyrenes obtained by simplification of the aristolochic acid molecule was demonstrated. The effect of modifying the three characteristic parts of the beta-nitrostyrene molecule has now been investigated. The results obtained in vitro and in vivo allow hypothesis of a mechanism of action for the various beta-nitrostyrene and nitrovinyl compounds studied and definition of the maximum simplification compatible with retention of biological activity.
D000818:Animals; D000970:Antineoplastic Agents / Q000138:chemical synthesis; D002287:Carcinoma, Krebs 2 / Q000188:drug therapy*; D055598:Chemical Phenomena; D002621:Chemistry; D066298:In Vitro Techniques; D009682:Magnetic Resonance Spectroscopy; D051379:Mice; D009574:Nitro Compounds / Q000138:chemical synthesis / Q000494:pharmacology*; D013343:Styrenes / Q000138:chemical synthesis / Q000494:pharmacology*; D014753:Vinyl Compounds / Q000138:chemical synthesis / Q000494:pharmacology*
D000970:Antineoplastic Agents; D009574:Nitro Compounds; D013343:Styrenes; D014753:Vinyl Compounds
Recherches en chimiotherapie antitumorale. X. Activité cytotoxique et antitumorale de beta-nitrostyrènes et de composés nitrovinyliques dérivés