title: [Rosette-formation phenomenon in autocultures of human venous blood leukocytes].
abstract: A method of human venous blood leukocyte culture permits to model immunological processes of an intact organism. Aggregation with lymphoid elements of the central target cell serves as a morphological expression of complicated cell interrelations under conditions of their extracorporeal cultivation. It may be that such interaction of mononuclears in the culture was caused by a special humoral factor generated by lymphocytes. The occurrence of the "rosette" phenomenon in the autoculture permits to suppose that there is a possibility of obtaining an antigenic information by lymphoid elements in the intact organism. The existence of a correlation between the processes of formation of intercellular associations in vitro and the severity of the disease in persons with allergy confirms this supposition.
mesh_terms: D000937:Antigen-Antibody Reactions; D003601:Cytotoxicity Tests, Immunologic; D006801:Humans; D006967:Hypersensitivity / Q000097:blood; D007104:Immune Adherence Reaction; D066298:In Vitro Techniques; D007962:Leukocytes / Q000276:immunology*; D008214:Lymphocytes / Q000276:immunology; D014680:Veins
vernacular_title: Fenomen rozetkoobrazovaniia v autokul'ture leĭkotsitov venoznoĭ krovi cheloveka