[Early recognition of a rejection crisis following kidney transplantation by determination of a low-molecular protease inhibitor in serum and urine].
The dynamic of the lowmolecular acid stable inhibitor in serum and urine was investigated in 10 patients with kidney transplants. The same was done with serum creatinin levels. In kidney transplantation changing serum levels and excretion of acid stable proteinase inhibitors early indicate the starting function of the kidney transplant. Rapid reduction of the inhibitors serum level and massive excretion are sign of the functioning of the kidney transplant even though creatinin levels remain elevated. An increasing inhibitor concentration in serum indicates the beginning of a rejection crisis. This is an easy check-up which takes only a few minutes.
D000293:Adolescent; D000328:Adult; D003404:Creatinine / Q000097:blood; D004791:Enzyme Inhibitors / Q000097:blood / Q000652:urine; D006084:Graft Rejection / Q000097:blood / Q000175:diagnosis* / Q000652:urine; D006801:Humans; D016030:Kidney Transplantation; D008970:Molecular Weight; D010447:Peptide Hydrolases / Q000097:blood / Q000652:urine; D011480:Protease Inhibitors; D013997:Time Factors; D014184:Transplantation, Homologous
D004791:Enzyme Inhibitors; D011480:Protease Inhibitors; D003404:Creatinine; D010447:Peptide Hydrolases
Frühzeitige Erkennung einer Abstossungskrise nach Nierentransplantation durch Bestimmung eines niedermolekularen Proteasen-Inhibitors im Serum und Harn