The non-teratogenicity of 2,4,5-trichlorophenoxyacetic acid in the rhesus monkey (Macaca mulatta).
The herbicide 2,4,5-trichlorophenoxyacetic acid (2,4,5-T) containing 0.05 ppm of tetrachlorodibenzo-p-dioxin, was administered to pregnant rhesus monkeys daily from Day 22 through Day 38 of gestation. At the dose levels administered, 0.05 mg/kg, 1 mg/kg, and 10 mg/kg, no evidence of toxicity was seen in the mother and no evidence of teratogenicity was seen in any of the offspring. Observations of the infants for 1 year following birth indicated that there was no toxicity due to the 2,4,5-T.
D015085:2,4,5-Trichlorophenoxyacetic Acid / Q000494:pharmacology* / Q000633:toxicity; D000818:Animals; D001724:Birth Weight / Q000187:drug effects; D005260:Female; D005865:Gestational Age; D006128:Growth / Q000187:drug effects; D008253:Macaca mulatta; D011247:Pregnancy; D013723:Teratogens / Q000494:pharmacology*
D013723:Teratogens; D015085:2,4,5-Trichlorophenoxyacetic Acid