Congenital malformations associated with the administration of oral anticoagulants during pregnancy.
Three small infants whose mothers had received oral anticoagulant therapy during the first trimester of pregnancy are described. These infants all had hypoplasia of the nasal bones, and two had stippling of epiphyses and bones and deformities of the bones of the hand. One child is mentally retarded. It is suggested that these abnormalities may be related to maternal oral anticoagulant therapy during the first trimester.
D000014:Abnormalities, Drug-Induced / Q000209:etiology*; D000284:Administration, Oral; D000328:Adult; D000925:Anticoagulants / Q000008:administration & dosage / Q000009:adverse effects* / Q000627:therapeutic use; D001021:Aortic Valve / Q000601:surgery; D002348:Carpal Bones / Q000002:abnormalities; D002806:Chondrodysplasia Punctata / Q000139:chemically induced*; D005145:Face; D005260:Female; D005528:Foot / Q000000981:diagnostic imaging; D006225:Hand / Q000000981:diagnostic imaging; D006228:Hand Deformities, Congenital; D006350:Heart Valve Prosthesis; D006801:Humans; D007231:Infant, Newborn; D008297:Male; D008431:Maternal-Fetal Exchange; D008943:Mitral Valve / Q000601:surgery; D009295:Nasal Bone / Q000002:abnormalities*; D009666:Nose / Q000002:abnormalities*; D011247:Pregnancy; D011248:Pregnancy Complications / Q000188:drug therapy*; D011261:Pregnancy Trimester, First; D011859:Radiography
D000925:Anticoagulants