title: Isoniazid (I.N.H.) in the treatment of depressive syndrome: a pilot trial.
abstract: An account of a pilot trial of Isoniazid as an anti-depressant is given. About 70% of the total patients improved and above 50% of them improved markedly. The improvement was sustained even after withdrawal of the drug. No patient worsened and the drug was very well tolerated on the whole. These preliminary results of a pilot trial amply justifies further exhaustive study of this drug, particularly in depressions.
mesh_terms: D000328:Adult; D000928:Antidepressive Agents; D002986:Clinical Trials as Topic; D003863:Depression / Q000188:drug therapy*; D005260:Female; D006801:Humans; D007538:Isoniazid / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged
chemical_list: D000928:Antidepressive Agents; D007538:Isoniazid