title: Effects of diuril and dilantin on blood glucose and insulin levels in late pregnancy.
abstract: In order to evaluate the carbohydrate metabolic effects of certain drug therapies used in treating the toxemia syndrome, 75 term pregnant women were studied with two intravenous glucose tolerance tests performed 1 week apart. During the 2-hour tests, both blood glucose and plasma insulin were measured. The women were randomly assigned to three treatment groups, and during the week between tests they received:a) no drugs (control or C group);b) Diuril, 500 mg/day (Dgroup); or c)Dilantin, 100 mg, t.i.d. (DL group). Each group was of similar age, weight, and gestational age. There were no significant changes in any of the glucose curves. Both drug-treated groups demonstrated insulin changes. In contrast to the C group, the D group showed an elevation of the plasma insulin values during the second test, and the DL group had a lowering of plasma insulin levels in the second test. Thus, both drugs had minor effects on carbohydrate metabolism during short-term use. However, a more marked metabolic effect of these drugs must be considered when using them at higher dosages or for a longer duration.
mesh_terms: D001786:Blood Glucose / Q000032:analysis*; D002740:Chlorothiazide / Q000494:pharmacology* / Q000627:therapeutic use; D004040:Dietary Carbohydrates / Q000378:metabolism*; D005260:Female; D005951:Glucose Tolerance Test; D006801:Humans; D007328:Insulin / Q000097:blood*; D010672:Phenytoin / Q000494:pharmacology* / Q000627:therapeutic use; D011225:Pre-Eclampsia / Q000188:drug therapy* / Q000378:metabolism; D011247:Pregnancy; D011263:Pregnancy Trimester, Third; D011254:Pregnancy in Diabetics / Q000378:metabolism
chemical_list: D001786:Blood Glucose; D004040:Dietary Carbohydrates; D007328:Insulin; D010672:Phenytoin; D002740:Chlorothiazide