[Psychological studies of a long-term treatment of the neurovascular syndrom with Trivastal (author's tranls)].
With Trivastal, a double blind study including placebo control was carried out with 66 patients at the age between 55 and 67. These persons were patients of several practioners and were treated because of different phenomena of the neurovascular psychosyndrome. They received 1 dragee daily at the beginning of the treatment, then additional dragees up to the amount of 3, 4 and 5 (or 6 according to the case) over a period of 14 weeks. The control of efficiency consisted in 13 psychometrical measurements: Measurement of reaction time, flicker fusion test, "fluency"-tests according to Guilford, self rating scale for the measurement of general psycho-physical condition, several tests for the control of memory functions, projective tests to determine emotional factors and a semi-standardized interview for the control of subjective symptoms of the neurovascular psychosyndrome. Data were evaluated by variance analysis and covariance analysis. Trivastal improved the cerebral metabolism, so that the treatment resulted in an improvement of vigilance and of psychomotor functions, in a better adaptation to demands of everyday affairs and in a higher efficiency of different memory functions. Finally, the patients returned to a normal level of psychic behaviour and managed their social integration more easily.
D000368:Aged; D000704:Analysis of Variance; D001921:Brain / Q000378:metabolism; D002560:Cerebrovascular Circulation / Q000187:drug effects; D002561:Cerebrovascular Disorders / Q000188:drug therapy*; D002986:Clinical Trials as Topic; D003704:Dementia / Q000188:drug therapy*; D005260:Female; D006801:Humans; D007406:Interview, Psychological; D008297:Male; D008568:Memory / Q000187:drug effects; D008875:Middle Aged; D010879:Piperazines / Q000627:therapeutic use*; D010891:Piribedil / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*; D010919:Placebos; D011569:Psychiatric Status Rating Scales; D011594:Psychometrics; D011930:Reaction Time / Q000187:drug effects
D010879:Piperazines; D010919:Placebos; D010891:Piribedil
Langzeitbehandlung des neurovaskulären Psychosyndroms mit Trivastal. Psychologische Untersuchungen