[T and B lymphocytes in skin changes of cutaneous lymphoma (author's transl)].
In 30 patients with benign or malignant lymphoreticular proliferation of the skin (38 skin biopsies) the percentage of immunoglobulin-bearing (B) and of spontaneous rosette-forming (T) lymphocytes was determined in cell suspension from homogenized tissue. Four main classes of cutaneous lymphoma could be differentiated: lymphocyte-rich (more than 50% of the infiltrate cells, predominantly B-lymphocytic, predominantly T-lymphocytic, mixed B and T-lymphocytic), lymphocyte-depleted (less than 50% of infiltrate cells), reticulo-histio-monocytic infiltrates, and reticulo- or lymphosarcoma. A definite statement was not possible (other than in leukaemic processes) if the accumulation of lymphocytic cells represented the primary malignant process rather than a concomitant inflammatory reaction. A clinically useful differentiation was into hyperplasia, paraplasia and neoplasia, as this takes into account different histopathological characteristics of cutaneous lymphomas (reactive hyperplastic/autonomic proliferative: benign/malignant; reversible/irreversible; systemic/nonsystemic; metastasizing/nonmetastasizing).
D001402:B-Lymphocytes / Q000276:immunology; D002471:Cell Transformation, Neoplastic; D006801:Humans; D006965:Hyperplasia; D008223:Lymphoma / Q000097:blood* / Q000473:pathology; D016403:Lymphoma, Large B-Cell, Diffuse / Q000097:blood / Q000473:pathology; D008228:Lymphoma, Non-Hodgkin / Q000097:blood / Q000473:pathology; D012878:Skin Neoplasms / Q000276:immunology* / Q000473:pathology; D013601:T-Lymphocytes / Q000276:immunology
T- und B-Lymohpzyten in Hautveränderungen kutaner Lymphome. Ein Beitrag zur Klassifikation lymphoretikulärer Proliferation in der Haut