Tumor and normal tissue response to irradiation in vivo: variation with decreasing dose rates.
Continuous irradiation in vivo at dose rates ranging form 0.54 to 274 rads per minute was performed in mice using the EMT6 tumor, the gut clone system, and the bone-marrow CFU system. A progressive increase in D0 and decrease in ñ were seen with decreasing dose rates in the EMT6 tumor and the gut clone system. The D0 showed little change in the bone-marrow CFU system. These findings are related to the D2-D1 values obtained from split-dose experiments at conventional dose rates. The results do not fit the various mathematical models proposed for correlating the effects of continuous low-dose-rate irradiation and acute exposure.
D000818:Animals; D001853:Bone Marrow / Q000528:radiation effects; D001854:Bone Marrow Cells; D002587:Cesium Isotopes; D002999:Clone Cells / Q000528:radiation effects; D004307:Dose-Response Relationship, Radiation; D005260:Female; D007413:Intestinal Mucosa / Q000528:radiation effects; D007583:Jejunum / Q000473:pathology / Q000528:radiation effects; D008325:Mammary Neoplasms, Experimental / Q000401:mortality / Q000532:radiotherapy*; D008433:Mathematics; D051379:Mice; D008807:Mice, Inbred BALB C; D008962:Models, Theoretical; D009368:Neoplasm Transplantation; D011830:Radiation Effects; D011868:Radioisotopes; D011878:Radiotherapy / Q000379:methods; D011879:Radiotherapy Dosage; D014184:Transplantation, Homologous
D002587:Cesium Isotopes; D011868:Radioisotopes