title: Significance of autogenously regulated and constitutive synthesis of regulatory proteins in repressible biosynthetic systems.
abstract: The functional implications of the different modes of regulation have been examined systematically. The results lead to certain predictions. The regulatory protein in repressor-controlled systems is constitutively synthesised. In activator-controlled systems synthesis of the regulatory protein is autogenously regulated. There is favourable agreement between these predictions and published experimental evidence.
mesh_terms: D000596:Amino Acids / Q000096:biosynthesis; D001120:Arginine; D001426:Bacterial Proteins / Q000378:metabolism; D004790:Enzyme Induction; D004794:Enzyme Repression; D004926:Escherichia coli / Q000378:metabolism; D005809:Genes, Regulator; D007532:Isoleucine; D008954:Models, Biological; D009876:Operon; D014176:Protein Biosynthesis; D012486:Salmonella typhimurium / Q000378:metabolism; D014158:Transcription, Genetic; D014364:Tryptophan; D014633:Valine
chemical_list: D000596:Amino Acids; D001426:Bacterial Proteins; D007532:Isoleucine; D014364:Tryptophan; D001120:Arginine; D014633:Valine