[The protective effect of serotonin against the depolarizing influence of aminazine on the membrane potentials of mouse embryos, in vitro, at the 2-blastomere stage].
The action of chlorpromazine, serotonin and prostaglandin F2-alpha on the cellular membrane potential of 2-cell mouse embryos, as well as a protective effect of serotonin and prostaglandin F2-alpha against the inhibition of the membrane potential by chlorpromazine were studied. Chlorporomazine (1.10-5 g/ml) proved to induce a strong decrease of the membrane potential, but serotonin, prostaglandin F2-alpha were ineffective. Serotonin (1.10-4 g/ml) prevented the action of chlorpormazine (2.10-6 g/ml), whereas prostaglandin F2-alpha (4-8.10-6 g/ml) was ineffective in this respect.
D000818:Animals; D002746:Chlorpromazine / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D003864:Depression, Chemical; D004622:Embryo, Mammalian / Q000187:drug effects*; D008564:Membrane Potentials / Q000187:drug effects*; D051379:Mice; D011453:Prostaglandins / Q000494:pharmacology*; D012701:Serotonin / Q000494:pharmacology*; D013268:Stimulation, Chemical
D011453:Prostaglandins; D012701:Serotonin; D002746:Chlorpromazine
Zashchitnyĭ éffekt serotonina ot depoliarizuiushchego vliianiia aminazina na membrannyĭ potentsial émbrionov mysheĭ in vitro, nakhodiashchikhsia na stadii 2 blastomerov