Changes in the mitotic cycle induced by alpha-solanine.
Low concentrations of alpha-solanine stimulated the growth of cultured human fibroblasts, while higher concentrations (greater 30 mug ml-1) had a markedly inhibitory effect. Autoradiographic studies indicated that the stimulation of cell growth was due to a shortening of the G1 phase. Feulgen microdensitometry of cells treated with high doses of alpha-solanine revealed an abnormal accumulation of cells in G2. The response of cultured human fibroblasts to low doses of alpha-solanine is comparable to that of sex hormones on target tissues. It is concluded that by virtue of either its stimulatory or its inhibitory effect on cell growth, alpha-solanine could act as a human teratogen.
D001345:Autoradiography; D001706:Biopsy; D002478:Cells, Cultured; D003720:Densitometry; D005347:Fibroblasts / Q000187:drug effects; D006801:Humans; D008938:Mitosis / Q000187:drug effects*; D012867:Skin; D012992:Solanine / Q000494:pharmacology*; D013723:Teratogens / Q000494:pharmacology; D013936:Thymidine; D013997:Time Factors; D014316:Tritium
D013723:Teratogens; D014316:Tritium; D012992:Solanine; D013936:Thymidine