title: Clindamycin-associated colitis.
abstract: Four cases of clindamycin-associated colitis have recently been observed at Kansas University Medical Center. There have been a few reports in the literature of colitis associated with this antibiotic, and our 4 cases are similar to those noted previously. All had the onset of diarrhea 7-14 days following the initiation of clindamycin therapy; the diarrhea persisted for weeks after the drug was discontinued. Mucosal changes ranged from focal ulceration to pseudomembrane formation. Diarrhea in a patient on clindamycin should alert the physician to the possibility of antibiotic induced colitis, a condition with significant morbidity and occasional mortality.
mesh_terms: D000230:Adenocarcinoma / Q000601:surgery; D000284:Administration, Oral; D000328:Adult; D000368:Aged; D002512:Cephalothin / Q000627:therapeutic use; D002981:Clindamycin / Q000008:administration & dosage / Q000009:adverse effects* / Q000627:therapeutic use; D003092:Colitis / Q000139:chemically induced* / Q000188:drug therapy / Q000473:pathology; D003106:Colon / Q000473:pathology; D003967:Diarrhea / Q000139:chemically induced; D005260:Female; D005383:Finger Injuries / Q000601:surgery; D006801:Humans; D008175:Lung Neoplasms / Q000601:surgery; D008297:Male; D008875:Middle Aged; D011014:Pneumonia / Q000188:drug therapy; D011183:Postoperative Complications / Q000188:drug therapy; D011241:Prednisone / Q000627:therapeutic use; D012141:Respiratory Tract Infections / Q000188:drug therapy
chemical_list: D002981:Clindamycin; D002512:Cephalothin; D011241:Prednisone