Inhibition of estradiol-induced intranuclear inclusions by an anti-estrogen (nafoxidine) in mammotrophs of the Mongolian gerbil.
Nafoxidine, an anti-estrogen, inhibited the induction of intranuclear inclusions by estradiol in mammotrophs of the male Mongolian gerbil. No inclusions were observed with inhibitor alone or in control-injected gerbils. Estrogen may well act directly on mammotrophs in induction of nuclear inclusions.
D000818:Animals; D002467:Cell Nucleus / Q000187:drug effects / Q000648:ultrastructure; D004721:Endoplasmic Reticulum / Q000648:ultrastructure; D004958:Estradiol / Q000494:pharmacology*; D005849:Gerbillinae; D006056:Golgi Apparatus / Q000648:ultrastructure; D008297:Male; D009256:Nafoxidine / Q000494:pharmacology*; D010902:Pituitary Gland / Q000187:drug effects* / Q000648:ultrastructure; D011759:Pyrrolidines / Q000494:pharmacology*
D011759:Pyrrolidines; D009256:Nafoxidine; D004958:Estradiol