Decreased inhibition of platelet aggregation by PGE1 in children with cystic fibrosis and their parents.
PGE1 inhibited ADP-induced platelet aggregation in children with cystic fibrosis and their parents to a much lesser extent than in normal controls. We suggest that this may be a reliable test for heterozygote carriers of cystic fibrosis.
D000244:Adenosine Diphosphate / Q000494:pharmacology; D000328:Adult; D002353:Carrier State / Q000097:blood; D002648:Child; D002986:Clinical Trials as Topic; D003550:Cystic Fibrosis / Q000097:blood* / Q000175:diagnosis; D003864:Depression, Chemical; D006801:Humans; D010974:Platelet Aggregation / Q000187:drug effects*; D011458:Prostaglandins E / Q000494:pharmacology*
D011458:Prostaglandins E; D000244:Adenosine Diphosphate