Human antisera detecting leukemia-associated antigens on autochthonous tumor cells.
Leukemia patients in remission were immunized with RAJI lymphoid tissue culture cell lines. Four of 7 patients developed antibody to the immunizing cell as well as to allogeneic leukemia cells. Sera from 3 patients were tested against autochthonous tumor cells either frozen or obtained at the time of disease relapse. Patient's sera were cytotoxic to their own leukemia cells; however, this cytotoxicity was lost at the time of relapse.
D000951:Antigens, Neoplasm / Q000032:analysis*; D002051:Burkitt Lymphoma / Q000276:immunology; D002460:Cell Line; D003601:Cytotoxicity Tests, Immunologic; D006801:Humans; D007106:Immune Sera; D007114:Immunization; D007938:Leukemia / Q000276:immunology*; D012075:Remission, Spontaneous
D000951:Antigens, Neoplasm; D007106:Immune Sera