The effect of testosterone and other adrenal steroids on PMS-induced ovulation in the immature rat.
17 alpha-hydroxyprogesterone (up to 200 mug/day) and 11 beta-hydroxyandrostenedione (up to 500 mug) had no effect on PMS-induced ovulation in intact immature rats. 10 mug/day of testosterone propoinate (TP) on days 28-30 of life decreased the percent of animals ovulating and the number of ova produced; this effect persisted in adrenalectomized animals with or without corticosterone replacement. Three daily doses of 10 mug TP increased the electrical threshold of the medial preoptic area in pentobarbital-blocked, PMS-stimulated animals. And TP decreased the rate of release and synthesis of FSH during the ovulatory surge, and the storage and rate of release of LH; it also inhibited the response to HCG in the PMS-primed animal, suggesting a direct target-organ effect.
D000311:Adrenal Glands / Q000502:physiology; D000315:Adrenalectomy; D000367:Age Factors; D000737:Androstenols / Q000494:pharmacology*; D000818:Animals; D006063:Chorionic Gonadotropin / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D004347:Drug Interactions; D004594:Electrophysiology; D005260:Female; D005640:Follicle Stimulating Hormone / Q000378:metabolism; D006064:Gonadotropins, Equine / Q000494:pharmacology*; D006801:Humans; D006908:Hydroxyprogesterones / Q000494:pharmacology*; D007031:Hypothalamus / Q000187:drug effects; D007986:Luteinizing Hormone / Q000378:metabolism; D010060:Ovulation / Q000187:drug effects*; D010902:Pituitary Gland / Q000378:metabolism; D051381:Rats; D013739:Testosterone / Q000494:pharmacology*
D000737:Androstenols; D006063:Chorionic Gonadotropin; D006064:Gonadotropins, Equine; D006908:Hydroxyprogesterones; D013739:Testosterone; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone