Intact and fragmented intracellular immunoglobulin in a case of non-secretory myeloma.
A patient is described with myeloma without paraproteinaemia or Bence Jones proteinuria in whom the tumour cells have been shown to contain monoclonal immunoglobulin. The use of immunoelectrophoresis and polyacrylamide gel electrophoresis has established, apparently for the first time, that the immunoglobulin components are present in the form of intact molecules and free light chains.
D000368:Aged; D000469:Alkaline Phosphatase / Q000097:blood; D002118:Calcium / Q000097:blood; D004591:Electrophoresis, Polyacrylamide Gel; D005260:Female; D005269:Femur / Q000000981:diagnostic imaging; D006801:Humans; D006811:Humerus / Q000000981:diagnostic imaging; D007070:Immunoglobulin A / Q000032:analysis; D007128:Immunoglobulin Fragments / Q000032:analysis; D007074:Immunoglobulin G / Q000032:analysis; D007075:Immunoglobulin M / Q000032:analysis; D007136:Immunoglobulins / Q000302:isolation & purification*; D008334:Mandible / Q000000981:diagnostic imaging; D009101:Multiple Myeloma / Q000000981:diagnostic imaging / Q000276:immunology* / Q000473:pathology; D009194:Myeloma Proteins / Q000032:analysis*; D010710:Phosphates / Q000097:blood; D011859:Radiography; D012709:Serum Albumin / Q000032:analysis; D012886:Skull / Q000000981:diagnostic imaging
D007070:Immunoglobulin A; D007128:Immunoglobulin Fragments; D007074:Immunoglobulin G; D007075:Immunoglobulin M; D007136:Immunoglobulins; D009194:Myeloma Proteins; D010710:Phosphates; D012709:Serum Albumin; D000469:Alkaline Phosphatase; D002118:Calcium