[New evaluation of effect of total colectomy and intestinal sterilization following portacaval shunt].
The effect of total colectomy and "intestinal sterilisation" following chronic portocaval shunt was investigated in 96 Sprague-Dawley rats: while both therapeutic procedures are of no significant impact on serum ammonia concentrations there is a significant reduction of brain octopamine, a known false neuro-chemical transmitter, and a clear response on aromatic amino acid levels in brain and plasma. The interference with central and peripheral neurotransmitters is suggested as an alternative mechanism in experimental encephalopathy.
D000641:Ammonia / Q000097:blood; D000818:Animals; D001923:Brain Chemistry; D003082:Colectomy; D004203:Disinfection; D004755:Enterobacteriaceae / Q000187:drug effects; D007422:Intestines / Q000382:microbiology*; D007612:Kanamycin / Q000494:pharmacology*; D009655:Octopamine / Q000032:analysis; D011167:Portacaval Shunt, Surgical; D051381:Rats; D014364:Tryptophan / Q000032:analysis
D009655:Octopamine; D007612:Kanamycin; D000641:Ammonia; D014364:Tryptophan
Neubewertung der Wirkung der totalen Colektomie und der intestinalen Sterilisation nach portocavalem Shunt