Effect of actinomycin D and estradiol on the response to LH-releasing hormone in neonatally androgenized femal rats.
The effect of estradiol, actinomycin D, or both, on pituitary response to LH-RH was studied in 6-month-old female rats which had been injected with testosterone propionate on the 2nd day of life. Estradiol significantly augmented the pituitary response to LH-RH. Actinomycin D did not significantly modify basal serum LH levels and pituitary response to LH-RH but did significantly inhibit the augmenting effect of estradiol on such a response.
D000818:Animals; D003609:Dactinomycin / Q000494:pharmacology*; D004357:Drug Synergism; D004958:Estradiol / Q000494:pharmacology*; D004965:Estrogen Antagonists; D005260:Female; D007987:Gonadotropin-Releasing Hormone / Q000494:pharmacology*; D006801:Humans; D007986:Luteinizing Hormone / Q000378:metabolism; D010053:Ovary / Q000187:drug effects; D010902:Pituitary Gland / Q000187:drug effects / Q000378:metabolism; D051381:Rats; D013739:Testosterone / Q000494:pharmacology
D004965:Estrogen Antagonists; D003609:Dactinomycin; D007987:Gonadotropin-Releasing Hormone; D013739:Testosterone; D004958:Estradiol; D007986:Luteinizing Hormone