Cerebral etiology of the acute respiratory distress syndrome: diphenylhydantoin prophylaxis.
Beagles and rats were subjected to hemorrhage regimens that induced the pulmonary complex of the Acute Respiratory Distress Syndrome (ARDS) in 6:6 dogs and 7:8 rats. Pretreatment with diphenylhydantoin (DPH), 5 mg/kg 1-2 hours preceding hemorrhage, resulted in complete prevention of the lung lesions in 8:8 dogs. (P smaller than 0.005). It also provided significant (P smaller than 0.01) protection to 8:11 rats. We offer this as circumstantial evidence that the ARDS has a centrineurogenic etiology.
D000818:Animals; D001982:Bronchial Diseases / Q000517:prevention & control; D004195:Disease Models, Animal; D004285:Dogs; D005260:Female; D002534:Hypoxia, Brain / Q000150:complications* / Q000517:prevention & control; D008168:Lung / Q000473:pathology; D008297:Male; D010672:Phenytoin / Q000627:therapeutic use*; D011654:Pulmonary Edema / Q000517:prevention & control; D051381:Rats; D012131:Respiratory Insufficiency / Q000209:etiology* / Q000517:prevention & control; D012771:Shock, Hemorrhagic / Q000150:complications
D010672:Phenytoin