Induction of rho- mutants in Saccharomyces cerevisiae by guanidine hydrochloride. II. Conditions that prevent rho- induction.
The induction of rho- "petite" mutants by guanidine hydrochloride (GuHCl) is inhibited in several conditions. Anaerobiosis inhibited the induction either with or without cell multiplication. Both nalidixic acid (NA) and cycloheximide (CH) inhibited the induction of mutants. On the other hand, chloramphenicol (CAP) produced a dual effect: at low concentration it stimulated, at high concentration it inhibited, the induction. The effect of these different inhibitors on the transformation of rho+ mother cells into rho- by GuHCl is discussed.
D000693:Anaerobiosis; D002701:Chloramphenicol / Q000494:pharmacology; D003513:Cycloheximide / Q000494:pharmacology; D004171:Diploidy; D006146:Guanidines / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D009153:Mutagens; D009154:Mutation / Q000187:drug effects*; D009268:Nalidixic Acid / Q000494:pharmacology; D012441:Saccharomyces cerevisiae / Q000187:drug effects*
D006146:Guanidines; D009153:Mutagens; D009268:Nalidixic Acid; D002701:Chloramphenicol; D003513:Cycloheximide