Investigation of the possible involvement of ketonic derivatives of polycyclic hydrocarbons in hydrocarbon carcinogenesis.
5,6-Dihydro-5-oxo-7,12-dimethylbenz(a)anthracene and 5,6-dihydro-6-oxo-7,12-dimethylbenz(a)anthracene are described. These compounds, which are isomeric with 7,12-dimethylbenz(a)anthracene-5,6-oxide (the K-region epoxide), were inactive in tests for tumor-initiating activity in mouse skin and tumor production in the s.c. tissue of the mouse.
D000818:Animals; D001551:Benz(a)Anthracenes / Q000378:metabolism; D002273:Carcinogens; D055598:Chemical Phenomena; D002621:Chemistry; D002845:Chromatography; D004622:Embryo, Mammalian; D007536:Isomerism; D007659:Ketones / Q000378:metabolism*; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D008815:Mice, Inbred Strains; D009374:Neoplasms, Experimental / Q000139:chemically induced; D010212:Papilloma / Q000139:chemically induced*; D010616:Phenanthrenes; D013057:Spectrum Analysis
D001551:Benz(a)Anthracenes; D002273:Carcinogens; D007659:Ketones; D010616:Phenanthrenes