title: [Immunoblastic adenopathy: clinical features, treatment and prognosis (author's transl)].
abstract: Clinical features, response to treatment and prognosis of 50 cases of immunoblastic lymph-adenopathy are reviewed. Most of the patients presented with generalized lymphadenopathy, hepatomegaly and/or splenomegaly, and fever. Hyperergic reactions such as pruritus, skin rash or eosinophilia were frequent. Erythrocytic sedimentation rate was increased by differing amounts. In some cases there was a polyclonal increase in immunoglobulins, while in others there was a reduction. Proven hypersensitivity to a wide spectrum of drugs was present in nine cases. Prognosis is uncertain: almost half of the patients died within one to forty-two months, some perhaps as a result of massive chemotherapy and/or radiotherapy. Best management probably is symptomatic treatment alone or with small doses of corticoids or immunosuppressives,  supplemented by antibiotics. It is concluded that immunoblastic lymphadenopathy represents a hyperimmune reaction and is not, despite the high death-rate, a true malignant lymphoma.
mesh_terms: D000328:Adult; D000367:Age Factors; D000368:Aged; D003937:Diagnosis, Differential; D004342:Drug Hypersensitivity / Q000150:complications; D005260:Female; D006529:Hepatomegaly / Q000150:complications; D006689:Hodgkin Disease / Q000175:diagnosis; D006801:Humans; D007154:Immune System Diseases / Q000150:complications / Q000175:diagnosis* / Q000628:therapy; D007136:Immunoglobulins / Q000032:analysis; D008206:Lymphatic Diseases / Q000150:complications / Q000175:diagnosis* / Q000628:therapy; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D012737:Sex Factors; D013163:Splenomegaly / Q000150:complications; D013577:Syndrome
chemical_list: D007136:Immunoglobulins
vernacular_title: Lymphogranulomatosis X. Klinisches Bild, Therapie und Prognose