title: [Immunological efficacy of smallpox vaccination in children with relative contraindications to vaccination].
abstract: Children (aged from 3 to 9 years) vaccinated against smallpox by multiple puncture (3 punctures by bifurcation needle), by a single cut and with vaccine diluted with a double dose of the solvent were observed. Vaccination by the methods tested considerably diminished the vaccinal reactions and failed to influence appreciably the formation of a full-value humoral immunity; only dilution of the vaccination material reduced the dynamics of the immunogenesis at the early periods after the vaccination. In children aged 3--5 and 6--9 years general vaccinal reactions were of the same character, whereas local reactions and immunological response were more pronounced in older children. A method of multiple puncture is recommended for mass vaccinations and also for vaccination of children with relative contraindications to the vaccinations.
mesh_terms: D000917:Antibody Formation; D002648:Child; D002675:Child, Preschool; D006801:Humans; D007070:Immunoglobulin A / Q000032:analysis; D007074:Immunoglobulin G / Q000032:analysis; D007075:Immunoglobulin M / Q000032:analysis; D012899:Smallpox / Q000517:prevention & control*; D012900:Smallpox Vaccine / Q000008:administration & dosage*; D014611:Vaccination / Q000379:methods*
chemical_list: D007070:Immunoglobulin A; D007074:Immunoglobulin G; D007075:Immunoglobulin M; D012900:Smallpox Vaccine
vernacular_title: Izuchenie immunologicheskoĭ éffektivnosti protivoospennoĭ vaktsinatsii deteĭ s otnositel'nymi protivopokazaniiami k privivkam