Fatal overdose from Bendectin.
A three-year old male ingested approximately 100 tablets of Bendectin. He developed tonic-clonic seizures followed by cardiac arrest. Toxicologic analysis yielded high levels of doxylamine, dicyclomine, and pyridoxine in blood, peritoneal fluid, and tissue homogenates. The antihistamine, doxylamine succinate appears to be the toxic constituent. Analytical methods used to document the case are herein described.
D000061:Accidents, Home; D001344:Autopsy; D002675:Child, Preschool; D002849:Chromatography, Gas; D003509:Cyclohexanecarboxylic Acids / Q000032:analysis / Q000506:poisoning*; D003510:Cyclohexanes / Q000032:analysis / Q000506:poisoning; D003692:Delayed-Action Preparations / Q000506:poisoning; D004048:Diethylamines / Q000032:analysis / Q000506:poisoning; D004319:Doxylamine / Q000032:analysis / Q000506:poisoning*; D004338:Drug Combinations; D006801:Humans; D008297:Male; D001261:Pulmonary Atelectasis / Q000139:chemically induced; D011725:Pyridines / Q000506:poisoning*; D011736:Pyridoxine / Q000032:analysis / Q000506:poisoning*; D013056:Spectrophotometry, Ultraviolet
D003509:Cyclohexanecarboxylic Acids; D003510:Cyclohexanes; D003692:Delayed-Action Preparations; D004048:Diethylamines; D004338:Drug Combinations; D011725:Pyridines; D004319:Doxylamine; D011736:Pyridoxine