Alprenolol in angina pectoris. A comparative study of the tablet form and slow-release formulation.
In a double-blind crossover trial in angina pectoris patients, alprenolol in a slow-release formulation (Aptin Durules) was compared with ordinary Aptin tablets. Four hundred mg per day in tablets given four times a day produced the same increase in exercise tolerance five hours after last intake as did an equivalent dose of slow-release formulation given twice per day nine hours after intake. Aptin Durules in double the dosage had a considerably greater effect. An optimal, sustained and antianginal effect of alprenolol is best achieved by giving 400 to 800 mg per day of slow-release formulation with 10 to 12 hours' dosage interval.
D000368:Aged; D000526:Alprenolol / Q000008:administration & dosage* / Q000097:blood / Q000627:therapeutic use; D000787:Angina Pectoris / Q000097:blood / Q000188:drug therapy*; D002986:Clinical Trials as Topic; D003692:Delayed-Action Preparations; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D005082:Physical Exertion; D010919:Placebos; D013607:Tablets
D003692:Delayed-Action Preparations; D010919:Placebos; D013607:Tablets; D000526:Alprenolol