Significance of autogenously regulated and constitutive synthesis of regulatory proteins in repressible biosynthetic systems.
The functional implications of the different modes of regulation have been examined systematically. The results lead to certain predictions. The regulatory protein in repressor-controlled systems is constitutively synthesised. In activator-controlled systems synthesis of the regulatory protein is autogenously regulated. There is favourable agreement between these predictions and published experimental evidence.
D000596:Amino Acids / Q000096:biosynthesis; D001120:Arginine; D001426:Bacterial Proteins / Q000378:metabolism; D004790:Enzyme Induction; D004794:Enzyme Repression; D004926:Escherichia coli / Q000378:metabolism; D005809:Genes, Regulator; D007532:Isoleucine; D008954:Models, Biological; D009876:Operon; D014176:Protein Biosynthesis; D012486:Salmonella typhimurium / Q000378:metabolism; D014158:Transcription, Genetic; D014364:Tryptophan; D014633:Valine
D000596:Amino Acids; D001426:Bacterial Proteins; D007532:Isoleucine; D014364:Tryptophan; D001120:Arginine; D014633:Valine