title: Cycloplegics and mydriatics. Tolerance, habituation, and addiction to topical administration.
abstract: A patient had tolerance, habituation, and addiction to the topical use of a combination of cyclopentolate hydrochloride and tropicamide. He also developed a blotchy, diffuse epithelial keratitis that disappeared when the drugs were discontinued.
mesh_terms: D000287:Administration, Topical; D000328:Adult; D000577:Amides / Q000506:poisoning / Q000627:therapeutic use; D001007:Anxiety; D003519:Cyclopentolate / Q000008:administration & dosage / Q000506:poisoning* / Q000627:therapeutic use; D004338:Drug Combinations; D004361:Drug Tolerance; D006801:Humans; D007634:Keratitis / Q000139:chemically induced; D008297:Male; D009184:Mydriatics / Q000008:administration & dosage / Q000506:poisoning* / Q000627:therapeutic use; D009325:Nausea / Q000209:etiology; D010648:Phenylacetates / Q000506:poisoning*; D011725:Pyridines / Q000506:poisoning* / Q000627:therapeutic use; D012472:Salivation / Q000209:etiology; D013375:Substance Withdrawal Syndrome; D019966:Substance-Related Disorders; D014202:Tremor / Q000209:etiology; D014839:Vomiting / Q000209:etiology
chemical_list: D000577:Amides; D004338:Drug Combinations; D009184:Mydriatics; D010648:Phenylacetates; D011725:Pyridines; D003519:Cyclopentolate