A rapid method for measuring miotic activity of drugs in the intact mouse eye.
A rapid and precise method for evaluating the miotic activity of cholinergic drugs has been developed based on Long's method for measuring the rate of mydriasis. The rate of reversal of mydriasis developed previously in the intact mouse eye by a mild mydriatic (phenycyclidine) is used to evaluate the miotic activity. The method provides a useful tool for measuring and comparing the miotic activity of acetylcholine agonists and cholinesterase inhibitors.
D000577:Amides / Q000494:pharmacology; D000818:Animals; D001115:Arecoline / Q000494:pharmacology; D001285:Atropine / Q000494:pharmacology; D002800:Cholinesterase Inhibitors / Q000494:pharmacology*; D003517:Cyclopentanes / Q000031:analogs & derivatives; D004123:Dimethylamines / Q000494:pharmacology; D004347:Drug Interactions; D008029:Lighting; D008722:Methods; D051379:Mice; D008853:Microscopy; D008916:Miotics / Q000494:pharmacology*; D009184:Mydriatics / Q000494:pharmacology*; D010277:Parasympathomimetics / Q000494:pharmacology*; D010622:Phencyclidine / Q000494:pharmacology; D010648:Phenylacetates / Q000494:pharmacology; D011680:Pupil / Q000187:drug effects*; D011725:Pyridines / Q000494:pharmacology; D013997:Time Factors
D000577:Amides; D002800:Cholinesterase Inhibitors; D003517:Cyclopentanes; D004123:Dimethylamines; D008916:Miotics; D009184:Mydriatics; D010277:Parasympathomimetics; D010648:Phenylacetates; D011725:Pyridines; D001115:Arecoline; D001285:Atropine; D010622:Phencyclidine