Studies on lankacidin-group (T-2636) ANTIBIOTICS. IX Preparation of C-labeled lankacidin C 14-propionate.
To investigate the metabolic fate of lankacidin C 14-propionate in experimental animals, the 14-C-labeled antibiotic was prepared by the fermentation of Streptomyces rochei var, volubilis in the presence of various 14-C-labeled organic carboxylic acids, amino acids and carbohydrates. Significant incorporation (20 similar to 40%) was observed with L-methionine-methyl-14-C. Lankacidin C 14-propionate-14-C (specific activity 49.6 muCi/mg) was obtained from lankacidin C-14-C and ethyl propionate by the action of an acylase of the streptomyces.
D000215:Acylation; D000596:Amino Acids / Q000378:metabolism; D000818:Animals; D000900:Anti-Bacterial Agents / Q000096:biosynthesis* / Q000302:isolation & purification; D050260:Carbohydrate Metabolism; D002250:Carbon Radioisotopes; D002264:Carboxylic Acids / Q000378:metabolism; D007783:Lactones / Q000096:biosynthesis / Q000302:isolation & purification; D008715:Methionine / Q000378:metabolism; D051379:Mice; D011422:Propionates / Q000378:metabolism; D051381:Rats; D013302:Streptomyces / Q000032:analysis; D013997:Time Factors
D000596:Amino Acids; D000900:Anti-Bacterial Agents; D002250:Carbon Radioisotopes; D002264:Carboxylic Acids; D007783:Lactones; D011422:Propionates; D008715:Methionine