Toxicity of metrizamide and meglumine iocarmate in the spinal subarachnoid space. An experimental study in rats with special reference to long-term effects.
The toxic effects of metrizamide, a new non-ionic contrast medium, and of meglumine iocarmate (Dimer-X), were investigated after injection into the spinal subarachnoid space of rats. Convulsions were seen in 8 of 11 animals with meglumine iocarmate. No such irritative effects seen with metrizamide. Histologic examiniation of the spinal cord was carried out here 4 months. No changes were seen which could be ascribed to toxic effects of the contrast media.
D000818:Animals; D002490:Central Nervous System / Q000187:drug effects*; D003287:Contrast Media / Q000008:administration & dosage / Q000633:toxicity*; D005260:Female; D008297:Male; D009192:Myelography; D051381:Rats; D012640:Seizures / Q000139:chemically induced; D013346:Subarachnoid Space; D013997:Time Factors
D003287:Contrast Media