Lysocellin, a new polyether antibiotic. I. Isolation, purification, physico-chemical and biological properties.
A new antibiotic, lysocellin (K-5610), WAS ISOLATED FROM Streptomyces cacaoi var. asoensis K-9 Met-. Lysocellin was obtained as a colorless crystalline needles from both the cultural filtrate and the mycelium of the organism. The antibiotic melted at 158 similar to 160 degrees C and had a molecular formula C34H59O10Na-1/2H2O. It had antimicrobial activity against gram-positive bacteria, antibiotic-resistant Staphyloccus aureus and some fungi, but not against gram-negative bacteria. Based on its physico-chemical and biological properties lysocellin was identified as a new polyether antibiotic.
D000818:Animals; D000900:Anti-Bacterial Agents / Q000032:analysis / Q000302:isolation & purification* / Q000494:pharmacology; D000935:Antifungal Agents / Q000032:analysis / Q000302:isolation & purification / Q000494:pharmacology; D001419:Bacteria / Q000187:drug effects; D055598:Chemical Phenomena; D002621:Chemistry; D002627:Chemistry, Physical; D004352:Drug Resistance, Microbial; D004987:Ethers / Q000302:isolation & purification / Q000494:pharmacology; D051379:Mice; D013210:Staphylococcus / Q000187:drug effects; D013302:Streptomyces / Q000032:analysis
D000900:Anti-Bacterial Agents; D000935:Antifungal Agents; D004987:Ethers