Hepatic artery ligation in treatment of carcinoid syndrome.
In a patient with malignant carcinoid syndrome with metastasis to the liver, cardiac lesions, pulmonary hypertension, pellagra-like skin lesions and depression developed. Her disability progressed despite medical therapy and two courses of chemotherapy. The primary tumour had been resected but the metastatic mass in the liver could not be resected because of its anatomic position. The dramatic improvement after hepatic artery ligation was correlated with urinary 5-hydroxyindole acetic acid excretion.
D000368:Aged; D000792:Angiography; D003520:Cyclophosphamide / Q000627:therapeutic use; D005260:Female; D005472:Fluorouracil / Q000627:therapeutic use; D006499:Hepatic Artery / Q000601:surgery*; D006801:Humans; D006897:Hydroxyindoleacetic Acid / Q000652:urine; D007082:Ileum / Q000601:surgery; D007414:Intestinal Neoplasms / Q000601:surgery*; D008026:Ligation; D008113:Liver Neoplasms / Q000188:drug therapy / Q000601:surgery*; D008303:Malignant Carcinoid Syndrome / Q000188:drug therapy / Q000601:surgery*; D008727:Methotrexate / Q000627:therapeutic use; D009362:Neoplasm Metastasis; D011877:Radionuclide Imaging; D012711:Serum Albumin, Radio-Iodinated
D012711:Serum Albumin, Radio-Iodinated; D006897:Hydroxyindoleacetic Acid; D003520:Cyclophosphamide; D005472:Fluorouracil; D008727:Methotrexate