title: Lipid accumulation in smooth muscle cell lysosomes im primate atherosclerosis.
abstract: Cytochemical and ultrastructural examination of the developing atherosclerotic lesion in hypercholesterolemic rhesus monkeys reveals that lipid is sequestered within lysosomes of aortic smooth muscle cells. A common pathway in the development of sclerotic arterial disease appears to be overloading of vascular smooth muscle cell lysosomes with a variety of metabolites. This may occur as a consequence of an excess of substrate or because of a congenital deficiency of a lysosomal hydrolase.
mesh_terms: D000818:Animals; D001011:Aorta / Q000378:metabolism / Q000648:ultrastructure*; D001161:Arteriosclerosis / Q000473:pathology*; D004036:Diet, Atherogenic; D005260:Female; D006651:Histocytochemistry; D006937:Hypercholesterolemia / Q000473:pathology; D050356:Lipid Metabolism; D008247:Lysosomes / Q000378:metabolism* / Q000648:ultrastructure; D008253:Macaca mulatta; D008854:Microscopy, Electron; D009130:Muscle, Smooth / Q000378:metabolism / Q000648:ultrastructure*