title: Studies concerning the hsitotoxicity of isobutyl-2-cyanoacrylate tissue adhesive when employed as an oral hemostat.
abstract: An experimental study was implemented to determine the effectiveness of isobutyl-2-cyanoacrylate (bucrylate) as an oral hemostat, its influence on sequential wound healing, and its potential as a carcinogen. Segregated groups of equal numbers of male and female Long-Evans Hooded Rats underwent deep (socket) and superficial (surface) aerosol placement of bucrylate to maxillary molar extraction sites. Bucrylate proved to be an effective oral hemostat, rapidly retarding postextraction hemorrhage. Deep placement of the adhesive resulted in retarding of healing and lingering macrohistiocytic aggregates in wounds. Superficial placement of the material resulted in very little long-term macrohistiocytic response, and would healing showed little retardation. A neoplastic potential was not demonstrated for bucrylate.
mesh_terms: D000336:Aerosols; D000539:Alveolar Process / Q000033:anatomy & histology; D000818:Animals; D001772:Blood Cell Count; D002015:Bucrylate / Q000008:administration & dosage / Q000494:pharmacology*; D003487:Cyanoacrylates / Q000494:pharmacology*; D005260:Female; D005549:Foreign-Body Reaction / Q000139:chemically induced; D006097:Granulation Tissue / Q000033:anatomy & histology; D006490:Hemostatics / Q000494:pharmacology*; D008297:Male; D010519:Periodontium / Q000033:anatomy & histology / Q000187:drug effects*; D051381:Rats; D014081:Tooth Extraction; D014945:Wound Healing / Q000187:drug effects
chemical_list: D000336:Aerosols; D003487:Cyanoacrylates; D006490:Hemostatics; D002015:Bucrylate