Inhibition of macromolecular synthesis in L1210 mouse leukemia ascites cells by hycanthone.
Hycanthone inhibits macromolecular synthesis in L1210 cells. At the same concentrations of hycanthone, DNA synthesis is inhibited to a greater extent than the synthesis of RNA. There is an inhibition by the drug of the synthesis of ribosomal precursor RNA; the synthesis of other types of RNA including heterogeneous and small-molecular-weight, also appears to be inhibited. Maturation of 45-S RNA does not seem to be affected, and there is a partial reversal of inhibition of both DNA and RNA synthesis by washing the cells free of hycanthone.
D000818:Animals; D004273:DNA, Neoplasm / Q000096:biosynthesis*; D005029:Ethylenediamines / Q000494:pharmacology*; D007939:Leukemia L1210 / Q000378:metabolism*; D051379:Mice; D009363:Neoplasm Proteins / Q000096:biosynthesis*; D014176:Protein Biosynthesis / Q000187:drug effects; D012334:RNA, Neoplasm / Q000096:biosynthesis*; D013892:Thioxanthenes / Q000494:pharmacology*; D013936:Thymidine / Q000378:metabolism; D014158:Transcription, Genetic / Q000187:drug effects; D014529:Uridine / Q000378:metabolism
D004273:DNA, Neoplasm; D005029:Ethylenediamines; D009363:Neoplasm Proteins; D012334:RNA, Neoplasm; D013892:Thioxanthenes; D013936:Thymidine; D014529:Uridine