title: Premature craniosynostosis-a complication of thyroid replacement therapy.
abstract: Three hypothyroid children with premature craniosynostosis are presented, who have been treated intensively with 1-thyroxine from early infancy. It is postulated that the craniosynostosis is the result of iatrogenic hyperthyroidism during a critical period of skull growth. Various regimens of treatment for hypothyroidism are discussed with recommendations for avoiding this potentially hazardous complication of therapy.
mesh_terms: D002648:Child; D003409:Congenital Hypothyroidism; D003398:Craniosynostoses / Q000139:chemically induced* / Q000000981:diagnostic imaging; D005260:Female; D006257:Head / Q000254:growth & development; D006801:Humans; D007037:Hypothyroidism / Q000000981:diagnostic imaging / Q000188:drug therapy*; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D011859:Radiography; D012886:Skull / Q000000981:diagnostic imaging; D013974:Thyroxine / Q000009:adverse effects* / Q000627:therapeutic use
chemical_list: D013974:Thyroxine