Ineffectiveness of Vi and chemically treated endotoxins as typhoid vaccines in mice challenged with a Salmonella typhosa-Salmonella typhimurium hybrid.
Purified Vi antigen, acetic anthydride-treated Salmonella typhosa endotoxin, and potassium methylate-treated S. typhosa endotoxin employed as vaccines in Swiss white mice failed to protect these animals against challenge with a  virulent S. typhimurium hybrid expressing S. typhosa antigens.
D000818:Animals; D000942:Antigens, Bacterial / Q000008:administration & dosage; D002954:Citrobacter / Q000276:immunology; D004731:Endotoxins / Q000627:therapeutic use*; D006824:Hybridization, Genetic; D007274:Injections, Intraperitoneal; D051379:Mice; D012485:Salmonella typhi / Q000276:immunology*; D012486:Salmonella typhimurium / Q000276:immunology*; D014436:Typhoid-Paratyphoid Vaccines / Q000627:therapeutic use*
D000942:Antigens, Bacterial; D004731:Endotoxins; D014436:Typhoid-Paratyphoid Vaccines