Efficacy of dyphylline (dihydroxypropyltheophylline) in exercise-induced bronchospasm.
The efficacy of dyphlline in prevention of exercise-induced bronchospasm (EIB) was studied in seven subjects. A single 15 mg/kg dose of dyphylline 40 minutes prior to exercise prevented EIB as documented by a significantly smaller mean greatest percent decrease in forced expiratory volume in one second when compared to placebo. Mean serum dyphylline concentrations 40 minutes after a dose of 15 mg/kg were probably in the lower portion of the therapeutic range.
D000293:Adolescent; D000328:Adult; D001986:Bronchial Spasm / Q000517:prevention & control*; D002986:Clinical Trials as Topic; D005541:Forced Expiratory Volume; D006801:Humans; D008450:Maximal Midexpiratory Flow Rate; D005082:Physical Exertion; D013806:Theophylline / Q000031:analogs & derivatives* / Q000097:blood / Q000627:therapeutic use; D014797:Vital Capacity
D013806:Theophylline