Estimating total cerebral blood flow from the initial slope of hydrogen washout curves.
An initial slope index of total cerebral blood flow, measured by the hydrogen clearance technique, shows a high correlation with flows calculated by bicompartmental analysis. In 247 flow measurements done on 41 rhesus monkeys, a linear regression analysis between these two methods of calculating flow shows a correlation coefficient of 0.928 with a standard error about y values of plus or minus 7.63. The initial slope index is not only faster but does not require that a steady state be maintained for ten minutes.
D000818:Animals; D001921:Brain / Q000098:blood supply*; D002560:Cerebrovascular Circulation; D006859:Hydrogen; D008253:Macaca mulatta; D008433:Mathematics; D008722:Methods; D012039:Regional Blood Flow
D006859:Hydrogen