[The effect of loading liver lysosomes with triton WR 1339 on the development of chronic toxic hepatitis].
Preliminary administration of triton WR 1339 produced a favourable effect on the course of chronic toxic hepatitis. This was expressed in a reduction of necrotic zones, a delay in development of connective tissue and in improvement of the functional capacity of the liver. Lysosomes of the liver of animals subjected to the action of CCl-4 under conditions of preliminary administration of a detergent were more stable to the injurious actions in vitro.
D000135:Acid Phosphatase / Q000378:metabolism; D000469:Alkaline Phosphatase / Q000378:metabolism; D000818:Animals; D002252:Carbon Tetrachloride Poisoning / Q000150:complications* / Q000201:enzymology / Q000473:pathology / Q000503:physiopathology; D056486:Chemical and Drug Induced Liver Injury / Q000201:enzymology / Q000209:etiology / Q000473:pathology / Q000517:prevention & control*; D002908:Chronic Disease; D007728:Kupffer Cells; D008099:Liver / Q000473:pathology; D008247:Lysosomes / Q000201:enzymology; D008297:Male; D009336:Necrosis; D011092:Polyethylene Glycols / Q000627:therapeutic use*; D000644:Quaternary Ammonium Compounds / Q000627:therapeutic use*; D051381:Rats; D011919:Rats, Inbred Strains
D000644:Quaternary Ammonium Compounds; D011092:Polyethylene Glycols; D000469:Alkaline Phosphatase; D000135:Acid Phosphatase
Vliianie nagruzki lizosom pecheni tritonom WR 1339 na razvitie khronicheskogo toksicheskogo gepatita