Effect of delayed local cooling on experimental spinal cord injury.
The authors report studies indicating that delayed local cooling is effective in minimizing the neurological deficits of experimental spinal cord injury in cats. Cortical evoked responses were useful in predicting the neurological outcome; untreated animals whose evoked response disappeared for 6 hours failed to recover whereas all treated animals in the same group recovered dramatically. Decompression by laminectomy alone proved ineffective. Possible explanations for the therapeutic effects of cooling and the significance of the delay are briefly discussed.
D000818:Animals; D002415:Cats; D003452:Cryosurgery / Q000379:methods*; D005069:Evaluation Studies as Topic; D005071:Evoked Potentials; D007796:Laminectomy; D013116:Spinal Cord / Q000503:physiopathology; D013119:Spinal Cord Injuries / Q000503:physiopathology / Q000628:therapy*; D013997:Time Factors