title: Silo-Filler's disease.
abstract: The effects of oxides of nitrogen inhalation are reported in a 21-year-old gardener exposed to silage gas. Initial nausea, cough and fever remitted, but respiratory failure developed 3 weeks later. Roentgenograms and lung function studies revealed pulmonary edema, volume restriction, and severely impaired gas exchange. Needle biopsy showed a nonspecific interstitial pneumonia. With steroid therapy all functional parameters except diffusing capacity returned to normal. Failure to inquire about non-occupational activities led to delayed diagnosis. A brief review of toxic effects of nitrogen oxides is presented.
mesh_terms: D000305:Adrenal Cortex Hormones / Q000627:therapeutic use; D000328:Adult; D001707:Biopsy, Needle; D006801:Humans; D008171:Lung Diseases / Q000175:diagnosis*; D008297:Male; D009585:Nitrogen Dioxide / Q000506:poisoning*; D011859:Radiography; D012129:Respiratory Function Tests; D012832:Silo Filler's Disease / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000188:drug therapy
chemical_list: D000305:Adrenal Cortex Hormones; D009585:Nitrogen Dioxide