title: Statistical analysis of the reproducibility of the intravenous glucose tolerance test and the serum insulin response to this test in the middle-aged men.
abstract: The reproducibility of the intravenous glucose tolerance test (IVGTT) and the serum insulin response to this test have been studied in 48 healthy middle-aged men participating in a health screening program. Two tests were done 4-6 weeks apart. The subjects were ambulatory, and no diet prescriptions other than recommendation of an overnight fast were given. Under these circumstances the correlation between the K values of the two tests was low (r equals 0.55), and the equation for linear regression was y equals 0.56 x + 0.61. The intraindividual variation was 21 per cent, expressed as the coefficient of variation. The early increases in glucose-stimulated serum insulin concentrations in the two tests were significantly correlated (r equals 0.87), and this equation for linear regress was y equals 0.81 x + 10. The coefficient of variation intraindividually for this determination was 20 per cent. We conclude that the K values of the IVGTTs must be judged with caution when obtained in ambulatory practice, especially when the result is used for preventive measures and long-term follow-up of asymptomatic individuals.
mesh_terms: D002986:Clinical Trials as Topic; D003327:Coronary Disease; D005951:Glucose Tolerance Test; D006306:Health Surveys; D006801:Humans; D007328:Insulin / Q000097:blood*; D008297:Male; D008875:Middle Aged; D011786:Quality Control; D012044:Regression Analysis; D013223:Statistics as Topic; D013997:Time Factors
chemical_list: D007328:Insulin