Nephrotoxicity of combined cephalothin-gentamicin regimen.
Two patients developed acute tubular necrosis, characterized clinically by acute oliguric renal failure, while they were receiving a combination of cephalothin sodium and gentamicin sulfate therapy. Patients who are given this drug regimen should be observed very carefully for early signs of nephrotoxicity. High doses of this antibiotic combination should be avoided especially in elderly patients. Patients with renal insufficiency should not be given this regimen.
D058186:Acute Kidney Injury / Q000139:chemically induced*; D000368:Aged; D001806:Blood Urea Nitrogen; D001996:Bronchopneumonia / Q000188:drug therapy; D002512:Cephalothin / Q000008:administration & dosage / Q000009:adverse effects* / Q000627:therapeutic use; D004357:Drug Synergism; D004359:Drug Therapy, Combination; D005260:Female; D005839:Gentamicins / Q000008:administration & dosage / Q000009:adverse effects* / Q000627:therapeutic use; D006801:Humans; D007683:Kidney Tubular Necrosis, Acute / Q000139:chemically induced*; D007684:Kidney Tubules / Q000473:pathology; D008875:Middle Aged; D011512:Proteus Infections / Q000188:drug therapy; D011552:Pseudomonas Infections / Q000188:drug therapy
D005839:Gentamicins; D002512:Cephalothin