Cellular and humoral immunity after clinical renal transplantation.
Cellular and humoral responses against donor lymphocytes were studied in ten kidney-transplant patients, nine of whom had well functioning grafts. No(T)cell-mediated cytotoxicity against donor cells was demonstrated. Specific anti-donor antibodies were found in two recipients with well-accepted grafts. A single immunological factor responsible for a favourable clinical course was not demonstrated. Neither complete T nor B cell tolerance against donor cells had developed, and a well-tolerated graft could coexist with antibodies directed against donor cells.
D000906:Antibodies; D003165:Complement System Proteins; D003601:Cytotoxicity Tests, Immunologic; D006650:Histocompatibility Testing; D006801:Humans; D007108:Immune Tolerance; D016030:Kidney Transplantation; D008213:Lymphocyte Activation; D008214:Lymphocytes / Q000276:immunology*; D013601:T-Lymphocytes / Q000276:immunology; D014181:Transplantation Immunology; D014184:Transplantation, Homologous
D000906:Antibodies; D003165:Complement System Proteins