title: Abrin and hurin: two new lymphocyte mitogens.
abstract: Two plant proteins, abrin from the seed of Abrus precatorius and hurin from the seed of Hura crepitans, are potent lymphocyte mitogens. The extent of stimulation of BALB/C AND CBA strain mouse spleens by these factors is significantly greater than that attained with PHA or PWM and requires thymus-derived lymphocytes. Abrin has been purified to electrophoretic homogeneity, physically characterized, and may undergo conversion from a toxic to mitogenic form. Hurin is the best mitogen we have tested.
mesh_terms: D000036:Abrin / Q000494:pharmacology; D000596:Amino Acids / Q000032:analysis; D000818:Animals; D004355:Drug Stability; D005690:Galactose / Q000032:analysis; D005944:Glucosamine / Q000032:analysis; D037102:Lectins / Q000494:pharmacology; D008214:Lymphocytes / Q000187:drug effects / Q000502:physiology*; D008358:Mannose / Q000032:analysis; D051379:Mice; D008807:Mice, Inbred BALB C; D008808:Mice, Inbred CBA; D008938:Mitosis / Q000187:drug effects; D008970:Molecular Weight; D010940:Plant Proteins / Q000494:pharmacology; D013154:Spleen / Q000187:drug effects / Q000502:physiology; D014961:X-Ray Diffraction
chemical_list: D000596:Amino Acids; D037102:Lectins; D010940:Plant Proteins; D000036:Abrin; D005944:Glucosamine; D008358:Mannose; D005690:Galactose