title: Urinary enzymes and kidney damage by aspirin and phenacetin.
abstract: Two groups of rats were given aspirin and phenacetin in their food at daily doses similar to those taken by humans suffering from analgesic abuse. Both drugs damaged the kidney proximal tubules although phenacetin affected the kidney more severely than aspirin. At the start of the experiment aspirin increased the urinary excretion of lactate dehydrogenase (LDH) while phenacetin raised the excretion of all four enzymes studies (acid phosphatase, alkaline phosphatase, glutamate dehydrogenase (GDH), LDH indicating generalised cellular injury. Subsequent samples of urine collected from rats up to seven weeks showed normal urinary enzyme levels. The value of urinary enzyme measurements in detecting renal damage by drugs is discussed.
mesh_terms: D000135:Acid Phosphatase / Q000652:urine*; D000469:Alkaline Phosphatase / Q000378:metabolism* / Q000652:urine; D000818:Animals; D001241:Aspirin / Q000494:pharmacology* / Q000506:poisoning; D005969:Glutamate Dehydrogenase / Q000652:urine*; D007668:Kidney / Q000187:drug effects / Q000201:enzymology*; D007687:Kidney Tubules, Proximal / Q000187:drug effects; D007770:L-Lactate Dehydrogenase / Q000378:metabolism* / Q000652:urine; D008297:Male; D010615:Phenacetin / Q000494:pharmacology* / Q000506:poisoning; D051381:Rats; D013997:Time Factors
chemical_list: D007770:L-Lactate Dehydrogenase; D005969:Glutamate Dehydrogenase; D000469:Alkaline Phosphatase; D000135:Acid Phosphatase; D010615:Phenacetin; D001241:Aspirin