Different responses of two mouse strains to 650 rads and protection by surgical stress.
Radiation survival of C57B1/6J mice after 650 rads improved from 1.7% to 66% when mice were stressed surgically one week before irradiation. Surgical stress one or three weeks before irradiation increased endogenous CFUs and decreased exogenous CFUs in C57B1/6J and DBA/1J mice. Survival may be related to the proportion of stem cells in different phases of the cell cycle, which was abnormal in C57B1/6J mice and compensated for by a greater number of nucleated cells per femur.
D000818:Animals; D001853:Bone Marrow / Q000528:radiation effects; D001854:Bone Marrow Cells; D002452:Cell Count; D002455:Cell Division; D002999:Clone Cells; D005269:Femur; D006400:Hematocrit; D006412:Hematopoietic Stem Cells / Q000528:radiation effects; D007958:Leukocyte Count; D051379:Mice; D008810:Mice, Inbred C57BL / Q000528:radiation effects; D008811:Mice, Inbred DBA / Q000528:radiation effects; D008815:Mice, Inbred Strains / Q000528:radiation effects*; D011829:Radiation Dosage; D011832:Radiation Injuries / Q000517:prevention & control*; D013154:Spleen / Q000166:cytology; D013312:Stress, Physiological; D013514:Surgical Procedures, Operative; D013997:Time Factors