The effect of terbutaline in exercise-induced asthma.
A double blind study of 5 asthmatic subjects in remission demonstrated that the severity of bronchoconstriction after exercise was decreased by a single oral dose of 5 mg of terbutaline. The effect lasted for at least 6 hours and was significantly better than the protection afforded by 20 mg of metaproterenol, which was itself more effective than a placebo. In these doses, neither terbutaline nor metaproterenol affected heart rate or blood pressure at rest or in exercise, and no drug-induced side effects were found.
D000293:Adolescent; D000328:Adult; D001249:Asthma / Q000188:drug therapy*; D001794:Blood Pressure / Q000187:drug effects; D002986:Clinical Trials as Topic; D004341:Drug Evaluation; D005260:Female; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D008297:Male; D009921:Metaproterenol / Q000008:administration & dosage / Q000627:therapeutic use; D008875:Middle Aged; D005082:Physical Exertion; D010919:Placebos; D013726:Terbutaline / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D013997:Time Factors
D010919:Placebos; D009921:Metaproterenol; D013726:Terbutaline