title: Effect of dietary safflower oil upon lipogenesis in neonatal lamb.
abstract: The effect of dietary safflower oil upon lipogenesis has been investigated in neonatal lambs. Preliminary experiments with lambs suckled by their mothers showed that there was a 10-fold increase in the rate of incorporation of [14-C] from acetate into fatty acids in adipose tissue slices during the first 10 days post partum. Barely detectable rates of [14-C] acetate incorporation into fatty acids were found in liver slices from lambs during the same period. In lambs given cows' milk from birth untill 11 days of age, there was also a 10-fold increase in the rate of lipogenesis in adipose tissue slices. Supplementing the diet of cows' milk with safflower oil (5 ml/lamb/day) resulted in significantly lower rates of lipogenesis in adipose tissue slices from 11 day old lambs. Administration of safflower oil had no effect upon the concentration of unesterified fatty acids, including linoleic acid, in the lamb adipose tissue slices. The data show that lipogenesis in ovine adipose tissue, like that in rodent liver and adipose tissue, is sensitive to dietary polyunsaturated fatty acids, and that, for the neonatal lamb, the effect of polyunsaturated fatty acids upon lipogenesis is not dependent upon an increase in the tissue concentration of polyunsaturated fatty acids.
mesh_terms: D000085:Acetates / Q000378:metabolism; D000273:Adipose Tissue / Q000378:metabolism; D000818:Animals; D000831:Animals, Newborn / Q000378:metabolism*; D002417:Cattle; D004041:Dietary Fats; D005230:Fatty Acids, Nonesterified / Q000096:biosynthesis / Q000097:blood; D005231:Fatty Acids, Unsaturated / Q000096:biosynthesis; D005260:Female; D008055:Lipids / Q000096:biosynthesis*; D008099:Liver / Q000378:metabolism; D008892:Milk; D009821:Oils / Q000494:pharmacology*; D009928:Organ Specificity; D012450:Safflower Oil / Q000494:pharmacology*; D012756:Sheep; D013997:Time Factors
chemical_list: D000085:Acetates; D004041:Dietary Fats; D005230:Fatty Acids, Nonesterified; D005231:Fatty Acids, Unsaturated; D008055:Lipids; D009821:Oils; D012450:Safflower Oil