Analysis of the dominance effect of a spontaneous recessive lethal in the mouse on homozygous and heterozygous genetic background.
A spontaneous lethal (l-15) without detectable dominant phenotypical effects has been studied in F-4 offspring on a homozygous (CBA/CBA) or a heterozygous (CBA/Ajax) genetic background. No significant dominance effect resulting in increased intra-uterine death or decreased mating ability was found irrespective of the genetic background.
D000818:Animals; D003433:Crosses, Genetic; D005260:Female; D005313:Fetal Death; D005799:Genes, Dominant; D005804:Genes, Lethal; D005808:Genes, Recessive; D006579:Heterozygote; D006720:Homozygote; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D010641:Phenotype; D011247:Pregnancy; D011336:Probability