The virulence of vaccine strains of Mycoplasma mycoides var. mycoides recovered from inoculated cattle.
The T1 and KH3J attenuated strains of M mycoides, well-known in Africa for immunisation against contagious bovine pleuropneumonia, were recovered from the lymph nodes of cattle at intervals up to three months after vaccination. Virulence titrations in mice indicated that the organisms recovered from cattle were of no greater virulence than the strains used for inoculation. There was, therefore, no suggestion that the use of attenuated vaccines in the field might be associated with reversion to virulence after inoculation.
D000818:Animals; D001428:Bacterial Vaccines / Q000008:administration & dosage; D002417:Cattle / Q000382:microbiology*; D007279:Injections, Subcutaneous; D008198:Lymph Nodes / Q000382:microbiology; D051379:Mice; D009174:Mycoplasma / Q000276:immunology / Q000302:isolation & purification* / Q000472:pathogenicity; D013997:Time Factors; D014774:Virulence
D001428:Bacterial Vaccines