title: The starved kidney: a defect in renal concentrating ability.
abstract: The renal tubular responsiveness to antidiuretic hormone was assessed in seven obese patients during starvation and feeding by an overnight dehydration test followed by exogenous vasopressin. All seven subjects showed a mean reduction of one-third in their maximum urinary osmolality on day 4 of starvation. Thes- data show that the renal tubule is partially insensitive to antidiuretic hormone at a time when it is also insensitive to mineralocorticoids.?Author
mesh_terms: D000328:Adult; D001835:Body Weight; D003681:Dehydration; D004032:Diet; D005215:Fasting; D006801:Humans; D007684:Kidney Tubules / Q000187:drug effects*; D008875:Middle Aged; D008901:Mineralocorticoids / Q000494:pharmacology; D009747:Nutritional Physiological Phenomena; D009765:Obesity / Q000378:metabolism; D009994:Osmolar Concentration; D013997:Time Factors; D014554:Urination / Q000187:drug effects; D014556:Urine; D014667:Vasopressins / Q000008:administration & dosage / Q000494:pharmacology*
chemical_list: D008901:Mineralocorticoids; D014667:Vasopressins