Stimulation of adenylate deaminase activity by serotonin.
After a single intraperitoneal injection of serotonin into rats adenylate deaminase activity in the mitochondrial fraction of the liver was stimulated. The conditions under which a twofold increase in the deamination of AMP occurred, after serotonin administration,were determined. Preliminary blocking of monamine oxidase activity did not prevent this effect of serotonin.
D000249:Adenosine Monophosphate; D000581:Amidohydrolases / Q000378:metabolism*; D000818:Animals; D004789:Enzyme Activation; D008297:Male; D008930:Mitochondria, Liver / Q000201:enzymology*; D010293:Pargyline / Q000494:pharmacology; D051381:Rats; D012701:Serotonin / Q000494:pharmacology*; D013268:Stimulation, Chemical
D012701:Serotonin; D000249:Adenosine Monophosphate; D010293:Pargyline; D000581:Amidohydrolases