Antiarrhythmic agents. 2-, 3-, And 4-substituted benzylamines.
The synthesis of a series of 2-, 3-, and 4-substituted benzylamine derivatives is described. These compounds were studied for their effect on experimental cardiac arrhythmias. Many of the derivatives, but in particular 2-(p-methoxyphenylethynyl)benzylamine (3d), alpha,alpha-dimethyl-4y(phenylethynyl)benzylamine (7a), and alpha,alpha-dimethyl-4-phenethylbenzylamine (12g), showed good antiarrhythmic activity.
D000588:Amines / Q000138:chemical synthesis* / Q000494:pharmacology; D000818:Animals; D000889:Anti-Arrhythmia Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D001593:Benzyl Compounds / Q000138:chemical synthesis* / Q000494:pharmacology; D001794:Blood Pressure / Q000187:drug effects; D004285:Dogs; D004562:Electrocardiography; D006339:Heart Rate / Q000187:drug effects; D009203:Myocardial Infarction / Q000503:physiopathology; D013329:Structure-Activity Relationship; D014693:Ventricular Fibrillation / Q000503:physiopathology
D000588:Amines; D000889:Anti-Arrhythmia Agents; D001593:Benzyl Compounds