title: [The effect of alcohols on mitochondrial monoamine oxidase activity].
abstract: Effects of alcohols on the activity of mitochondrial monoamine oxidase (MAO) were studied using rat liver mitochondria and highly purified MAO preparations from rat and pig liver. It was shown that benzyl, beta-phenylethyl and octyl alcohols caused a competitive and reversible inhibition of deamination of tyramine, 4-amino- and 4-metoxy-derivatives of beta-phenylethyl amine and practically failed to affect deamination of beta-phenylethyl amine and its 4-chloro-derivative. The inhibitory properties of aliphatic alcohols were exerted only when the carbohydrate chain had the length of five methylene residues.
mesh_terms: D000438:Alcohols / Q000494:pharmacology; D000818:Animals; D001593:Benzyl Compounds; D000440:Butanols; D002384:Catalysis; D003864:Depression, Chemical; D000431:Ethanol; D000441:Hexanols; D007700:Kinetics; D008930:Mitochondria, Liver / Q000201:enzymology*; D008995:Monoamine Oxidase / Q000378:metabolism; D008996:Monoamine Oxidase Inhibitors; D000442:Octanols; D000439:Pentanols; D010627:Phenethylamines; D051381:Rats; D013552:Swine; D014439:Tyramine
chemical_list: D000438:Alcohols; D001593:Benzyl Compounds; D000440:Butanols; D000441:Hexanols; D008996:Monoamine Oxidase Inhibitors; D000442:Octanols; D000439:Pentanols; D010627:Phenethylamines; D000431:Ethanol; D008995:Monoamine Oxidase; D014439:Tyramine
vernacular_title: Vliianie spirtov na aktivnost' mitokhondrial'noĭ monoaminoksidazy