Increased rate of alcohol removal from blood with oral fructose and sucrose.
The effect of oral glucose, fructose and sucrose on the disappearance rate for intravenously administered alcohol was studied in eight abstinent alcoholic subjects. The three sugars were ingested on separate days in random sequence. alcohol levels were determined at hourly intervals. During sugar ingestion, the mean rates of alcohol disappearance were: 19 plus or minus 1.4 mg/100 ml per hour (plus or minus SE), with glucose, 23.9 or minus 1.4 mg/100 ml per hour with sucrose, and 25.4 plus or minus 1.4 mg/100 ml per hour with fructose. Compared to glucose both fructose and sucrose increased the rate of alcohol from the blood. The blood levels of fructose were similar after the oral dose of 2 g/kg of fructose or 4 g/kg of sucrose.
D000328:Adult; D000437:Alcoholism / Q000097:blood* / Q000178:diet therapy; D001786:Blood Glucose / Q000378:metabolism; D004040:Dietary Carbohydrates / Q000008:administration & dosage / Q000627:therapeutic use; D000431:Ethanol / Q000097:blood*; D005632:Fructose / Q000097:blood / Q000494:pharmacology*; D005947:Glucose / Q000494:pharmacology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D013329:Structure-Activity Relationship; D013395:Sucrose / Q000494:pharmacology*; D013997:Time Factors
D001786:Blood Glucose; D004040:Dietary Carbohydrates; D005632:Fructose; D000431:Ethanol; D013395:Sucrose; D005947:Glucose