Effect of membranous structures of the Kupffer cells on blood clotting.
The effect of subcellular fractions of the endothelia kupffer cells on blood clotting was studied. Cells were obtained from the rabbit liver by magnetic fractionation and the subcellular structures were than isolated from them by differential centrifugation. The inner membranous structures were found to carry thromboplastic activity. No correlation was found between the blood-clotting potential of the intracellular structures of the endothelial cells and the level of their cathepsin C activity.
D000818:Animals; D001777:Blood Coagulation; D001808:Blood Vessels / Q000166:cytology; D002403:Cathepsins / Q000378:metabolism; D004727:Endothelium / Q000166:cytology; D007728:Kupffer Cells / Q000201:enzymology / Q000648:ultrastructure*; D008099:Liver / Q000098:blood supply / Q000201:enzymology / Q000648:ultrastructure; D008928:Mitochondria / Q000201:enzymology; D011817:Rabbits; D013347:Subcellular Fractions / Q000201:enzymology / Q000502:physiology; D013385:Succinate Dehydrogenase / Q000378:metabolism; D013925:Thromboplastin / Q000378:metabolism
D013925:Thromboplastin; D013385:Succinate Dehydrogenase; D002403:Cathepsins