Proteinuria as diagnostic marker after human kidney transplantation.
Molecular weight analyses of urinary proteins in 34 patients following cadaveric kidney transplantation were performed by SDS-PAA-electrophoresis in order to diagnose transplant complications. A micromolecular 'tubular' proteinuria (mw 70-10,000) was found in all post-operative urines. Later on during clinically normal periods the patients exhibited an unphysiological proteinuria of mw 70-40,000. Recurrence of tubular proteinuria was associated with rejection episodes and acute kidney failure. Twelve patients developed a macromolecular glomerular proteinuria (mw greater than 60,000), caused by recurrent glomerulonephritis, glomerular rejection disease or renal vein thrombosis. Steroid treatment reduced the glomerular permeability for macromolecules above mw 65,000.
D000208:Acute Disease; D002908:Chronic Disease; D006084:Graft Rejection; D006801:Humans; D007674:Kidney Diseases / Q000652:urine*; D007678:Kidney Glomerulus; D016030:Kidney Transplantation; D007684:Kidney Tubules; D008970:Molecular Weight; D011507:Proteinuria / Q000139:chemically induced; D012008:Recurrence; D013256:Steroids / Q000009:adverse effects; D014184:Transplantation, Homologous
D013256:Steroids