Smooth-pursuit eye movements, and diazepam, CPZ, and secobarbital.
This study examined the effects on smooth-pursuit eye tracking of single doses of CPZ (0.667 and 1.334 mg/kg), diazepam (0.071, 0.142, and 0.284 mg/kg), and secobarbital (100 mg). Only the barbiturate significantly affected the ability to follow a moving target with smooth-pursuit eye movements. In repeated testing of a single subject, 130 mg of secobarbital disrupted smooth-pursuit movements at least until 24 hrs after ingestion.
D000328:Adult; D002746:Chlorpromazine / Q000494:pharmacology*; D002986:Clinical Trials as Topic; D003975:Diazepam / Q000494:pharmacology*; D005133:Eye Movements / Q000187:drug effects*; D006801:Humans; D008297:Male; D012631:Secobarbital / Q000494:pharmacology*
D012631:Secobarbital; D003975:Diazepam; D002746:Chlorpromazine