Tumor initiation by N-acyloxy derivatives of piperidine and N-arylacetamides.
Four N-Acetoxy-N-arylacetamides previously found to be local sarcomagens in the rat have been found to be initiators of tumorigenesis in mouse skin. The order of activity was: N-acetoxy-2-acetamidophenanthrene greater than N-acetoxy-4-acetamino-stilbene similar to N-acetoxy-2-acetamido-fluorene greater than N-acetoxy-4-acetamidobiphenyl. Two substituted N-benzoyloxypiperidines previously shown to yield nitrenium ions on solvolysis in methanol also had initiating activity in mouse skin.
D000081:Acetamides / Q000633:toxicity*; D000818:Animals; D001555:Benzene Derivatives; D001713:Biphenyl Compounds; D005260:Female; D005464:Fluorobenzenes; D051379:Mice; D010616:Phenanthrenes; D010880:Piperidines / Q000633:toxicity*; D011230:Precancerous Conditions / Q000139:chemically induced*; D012878:Skin Neoplasms / Q000139:chemically induced*; D013267:Stilbenes; D013997:Time Factors
D000081:Acetamides; D001555:Benzene Derivatives; D001713:Biphenyl Compounds; D005464:Fluorobenzenes; D010616:Phenanthrenes; D010880:Piperidines; D013267:Stilbenes