title: Fine structure and pinocytic activity of the visceral epithelium of the rat yolk sac incubated in a culture medium with or without goat antirat-placenta-IgG.
abstract: The fine structure and pinocytic activity of the rat visceral yolk sac epithelium were examined electron microscopically after incubation in Krebs-Ringer-Phosphate solution containing either 125-I-labeled albumin or goat antirat-placenta-IgG or both compounds simultaneously. Addition of 125-I-albumin to the incubation medium stimulates the pinocytosis, whereas the addition of goat antirat-placenta-IgG, cross-reacting with the yolk sac tissue, causes a diminution of the pinocytic activity of the yolk sac epithelium. Fine structural alterations and lesions are generally noticed. Preincubation of yolk sacs in Krebs-Ringer-Phosphate solution containing goat antirat-placent-IgG and the subsequent postincubation in a new Krebs-Ringer-Phosphate medium with 125-I-albumin does not restore the original pinocytic activity of the visceral epithelial cells.
mesh_terms: D000818:Animals; D002462:Cell Membrane; D003470:Culture Media; D004848:Epithelium; D005260:Female; D006041:Goats / Q000276:immunology; D007106:Immune Sera; D007074:Immunoglobulin G / Q000032:analysis*; D008247:Lysosomes; D010586:Phagocytes; D010873:Pinocytosis; D010920:Placenta / Q000276:immunology; D051381:Rats; D012711:Serum Albumin, Radio-Iodinated; D014817:Vitelline Membrane / Q000166:cytology / Q000276:immunology* / Q000648:ultrastructure
chemical_list: D003470:Culture Media; D007106:Immune Sera; D007074:Immunoglobulin G; D012711:Serum Albumin, Radio-Iodinated