Responses of Clostridium botulinum type B and E progenitor toxins to some clostridial sulfhydryl-dependent proteases.
Sulfhydryl-dependent proteases produced by Clostridium botulinum types A, B, and F, Clostridium histolyticum, Clostridium sporogenes and Clostridium perfringens activate preferentially type E over type B progenitor toxin but less efficiently than trypsin. The results explain why activable toxin is demonstrable in culture of a strongly proteolytic type B strain.
D001905:Botulinum Toxins / Q000378:metabolism* / Q000633:toxicity; D003014:Clostridium botulinum / Q000201:enzymology*; D010447:Peptide Hydrolases / Q000378:metabolism*; D014357:Trypsin / Q000378:metabolism
D010447:Peptide Hydrolases; D014357:Trypsin; D001905:Botulinum Toxins