[Use of a 2-part model of i pharmacokinetics of gentaniycin for maintaining a constant blood concentration in infusion intravenous (an experimental study)].
Maintenance of constant antibiotic blood levels within the required ranges may be accomplished with mathematical modelling of the antibiotic pharmacokinetics. The problem solvation was illustrated on gentamicin. The kinetic analysis of the curves of the drug excretion from the blood after a one-moment intravenous administration of the antibiotic to cats provided estimation of the constants for a two-compartment model of its pharmacokinetics. The constant values were used for calculation of the intravenous infusion rate for gentamicin and the load dose value providing attainance and maintenance of the drug blood levels within the required ranges. The experimental testing of the regiments of gentamicin infusion showed satisfactory correlation of the theoretically supposed and practically found antibiotic blood levels.
D000818:Animals; D001407:Bacillus; D002415:Cats; D004305:Dose-Response Relationship, Drug; D005839:Gentamicins / Q000097:blood / Q000494:pharmacology*; D007263:Infusions, Parenteral / Q000295:instrumentation; D007700:Kinetics; D008433:Mathematics; D008826:Microbial Sensitivity Tests; D008954:Models, Biological; D013997:Time Factors
D005839:Gentamicins
Primenenie dvuchastevoĭ modeli farmakokinetiki gentamitsina dlia podderzhaniia ego postoiannoĭ kontsentratsii v krovi pri vnutrivennoĭ infuzii (éksperimental'noe issledovanie)