Matrical inclusions induced by clofibrate in hepatic microbodies of rats fed 2-acetylaminofluorene.
Abnormal inclusions in microbodies were induced by clofibrate in hepatocytes of hyperplastic liver nodules in rats fed 2-acetylaminofluorene. These were matrical tubules and plates, each with the same ultrastructural features as those reported previously by other investigators. A hyperplastic state of hepatocytes induced by hepatocarcinogens might be related to the formation of these inclusions in response to clofibrate.
D002994:Clofibrate / Q000494:pharmacology*; D005449:Fluorenes; D008099:Liver / Q000648:ultrastructure*; D008113:Liver Neoplasms / Q000139:chemically induced*; D008830:Microbodies / Q000187:drug effects* / Q000648:ultrastructure; D009374:Neoplasms, Experimental / Q000139:chemically induced; D009940:Organoids / Q000187:drug effects*
D005449:Fluorenes; D002994:Clofibrate