Anabolic agents in kidney disease: the effect of formebolone on protein synthesis in patients with renal insufficiency or nephrosis.
The anabolic activity of formebolone was studied in 7 patients with nephrosis or renal insufficiency by measuring the amount of 14C-leucine incorporated into plasma proteins as an index of protein synthesis. The data demonstrate that the incorporation of label into the plasma albumin fraction was significantly increased after formebolone administration.
D058186:Acute Kidney Injury / Q000378:metabolism*; D000328:Adult; D000368:Aged; D045930:Anabolic Agents / Q000008:administration & dosage*; D000734:Androstenediols / Q000008:administration & dosage*; D001798:Blood Proteins / Q000096:biosynthesis; D002250:Carbon Radioisotopes / Q000378:metabolism; D005260:Female; D005557:Formaldehyde / Q000008:administration & dosage / Q000031:analogs & derivatives; D006801:Humans; D007664:Ketosteroids / Q000008:administration & dosage; D007930:Leucine / Q000097:blood / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D009401:Nephrosis / Q000378:metabolism*; D014176:Protein Biosynthesis; D012709:Serum Albumin / Q000032:analysis
D045930:Anabolic Agents; D000734:Androstenediols; D001798:Blood Proteins; D002250:Carbon Radioisotopes; D007664:Ketosteroids; D012709:Serum Albumin; D005557:Formaldehyde; D007930:Leucine