title: Effect of oral contraceptive agents on vitamin nutrition status.
abstract: Effects of low estrogen combination type oral contraceptives on some of the biochemical parameters used for assessing vitamin nutritional status were investigated in a group of women who had used the pill for 6 to 12 months. Another group of women was examined initially and then at one or more points of time within the first 6 months of treatment. Following changes were observed in women treated with oral contraceptives: 1) increased excretion of kynurenic acid and xanthurenic acid following tryptophan load; 2) increased EGOT activity and also an increase in vitro stimulation of EGOT with added PALP; 3) increased plasma vitamin A levels; 4) fall in erythrocyte folate levels; 5) fall in erythrocyte transketolase activity with no change in vitro stimulation with TPP; and 6) fall in erythrocyte riboflavin concentration associated with a decrease in erythrocyte glutathione reductase activity and increase in vitro stimulation with FAD. Most of these changes were observed during the first few cycles of oral contraceptive treatment.
mesh_terms: D001219:Aspartate Aminotransferases / Q000097:blood; D003276:Contraceptives, Oral / Q000494:pharmacology*; D003280:Contraceptives, Oral, Synthetic / Q000009:adverse effects / Q000494:pharmacology*; D004338:Drug Combinations; D004912:Erythrocytes / Q000378:metabolism*; D004997:Ethinyl Estradiol / Q000494:pharmacology; D005040:Ethynodiol Diacetate / Q000494:pharmacology; D005260:Female; D005492:Folic Acid / Q000097:blood; D006400:Hematocrit; D006454:Hemoglobins / Q000378:metabolism; D006801:Humans; D007194:India; D007736:Kynurenic Acid / Q000652:urine; D009644:Norgestrel / Q000494:pharmacology; D012256:Riboflavin / Q000097:blood; D012959:Socioeconomic Factors; D014174:Transketolase / Q000097:blood; D014801:Vitamin A / Q000097:blood; D014815:Vitamins / Q000378:metabolism*; D014977:Xanthurenates / Q000652:urine
chemical_list: D003276:Contraceptives, Oral; D003280:Contraceptives, Oral, Synthetic; D004338:Drug Combinations; D006454:Hemoglobins; D014815:Vitamins; D014977:Xanthurenates; D014801:Vitamin A; D009644:Norgestrel; D004997:Ethinyl Estradiol; D005040:Ethynodiol Diacetate; D005492:Folic Acid; D014174:Transketolase; D001219:Aspartate Aminotransferases; D007736:Kynurenic Acid; D012256:Riboflavin