Induction of acrosome degeneration of mouse spermatozoa with blood serum collected from females in various hormonal states.
Blood serum collected from female mice treated with oestrogen and progesterone was assayed for its ability to induce acrosome degeneration. The maximum activity was found in serum obtained from females treated with 1.0 mug oestrogen/day for 5 days. Lower doses did not produce any significant difference from the control group. Blood serum from pregnant or ovariectomized females treated with progesterone did not significantly depress the incidence of acrosome degeneration. The possibility that removal of the acrosome may not be a morphological concomitant of capacitation in mice has been discussed.
D000818:Animals; D001769:Blood; D002369:Castration; D004967:Estrogens / Q000494:pharmacology; D004971:Estrus; D005260:Female; D066298:In Vitro Techniques; D008297:Male; D051379:Mice / Q000502:physiology; D011247:Pregnancy; D011270:Pregnancy, Animal; D011374:Progesterone / Q000494:pharmacology; D012737:Sex Factors; D013075:Sperm Capacitation; D013094:Spermatozoa
D004967:Estrogens; D011374:Progesterone