Specific inhibitory action of polyunsaturated fatty acids on lymphocyte transformation induced by PHA and PPD.
Both saturated (SFA) and unsaturated fatty acids (UFS) inhibited PHA- and PPD-induced lymphocyte transformation. The degree of inhibition varied with the nature of the fatty acid (FA) and further comparison with their effect on unstimulated lymphocyte cultures suggests a specific action of polyunsaturated fatty acid (PUFA) on the lymphocyte PHA- and -PPD interaction. These findings are briefly discussed in the light of similar observations with PUFA-derived prostaglandins.
D001095:Arachidonic Acids; D005231:Fatty Acids, Unsaturated / Q000494:pharmacology*; D006801:Humans; D037102:Lectins; D008041:Linoleic Acids / Q000494:pharmacology; D008213:Lymphocyte Activation / Q000187:drug effects*; D009829:Oleic Acids / Q000494:pharmacology; D010169:Palmitic Acids / Q000494:pharmacology; D013229:Stearic Acids / Q000494:pharmacology; D013936:Thymidine / Q000378:metabolism; D014316:Tritium; D014373:Tuberculin; D014529:Uridine / Q000378:metabolism
D001095:Arachidonic Acids; D005231:Fatty Acids, Unsaturated; D037102:Lectins; D008041:Linoleic Acids; D009829:Oleic Acids; D010169:Palmitic Acids; D013229:Stearic Acids; D014373:Tuberculin; D014316:Tritium; D013936:Thymidine; D014529:Uridine