A dissolution rate apparatus for the prediction of initial drug absorption patterns in beagles: tolbutamide tablets.
An apparatus utilizing liquid turbulence to simulate hydrodynamic conditions generated by gastrointestinal peristalsis was designed to estimate drug release from solid oral dosage forms; This turbulence was achieved through special arrangements of a pipetting pump to a dissolution chamber. By adjusting the flow rate of the pump to deliver and withdraw a fixed volume of dissolution medium per minute, a correlation was developed between dissolution rates and absorption patterns in beagles of two commerical tolbutamide tablets, A and B, and a micronized tolbutamide suspensionmon the basis of this relationship, it was possible to predict the initial absorption patterns of two misformulated tablets, C and D.
D000818:Animals; D002845:Chromatography; D004285:Dogs; D004339:Drug Compounding; D005260:Female; D007408:Intestinal Absorption; D007700:Kinetics; D008297:Male; D008954:Models, Biological; D012995:Solubility; D013535:Suspensions; D013607:Tablets; D013678:Technology, Pharmaceutical / Q000295:instrumentation*; D014044:Tolbutamide / Q000032:analysis / Q000378:metabolism*
D013535:Suspensions; D013607:Tablets; D014044:Tolbutamide