Platelet reactivity ex vivo and in vivo after acute and chronic treatment with sodium caprylate.
The effect of sodium caprylate on platelet function and other hematological parameters was studied, using rabbits as experimental animals. Intravenous administration of caprylate resulted in a pronounced, although transient, inhibition of platelet reactivity as measured by the laser technique. A single oral dose of caprylate had no effect on platelet adhesiveness. Long-term oral administration of caprylate (2 and 3 weeks) to rabbits resulted in a progressive and significant decrease in platelet adhesiveness in these animals compared to that in a control group receiving saline. However, the platelet reactivity to laser damage was not changed after administration of caprylate for 3 weeks. Other hematological parameters such as hematocrit, plasma cholesterol, triglycerides, and ketone body concentrations were not altered by the treatment.
D000090:Acetoacetates / Q000097:blood; D000284:Administration, Oral; D000818:Animals; D001792:Blood Platelets / Q000187:drug effects*; D001835:Body Weight; D002087:Butyrates / Q000097:blood; D002210:Caprylates / Q000008:administration & dosage / Q000494:pharmacology*; D002784:Cholesterol / Q000097:blood; D005260:Female; D006400:Hematocrit; D007275:Injections, Intravenous; D007657:Ketone Bodies / Q000097:blood; D007834:Lasers; D008297:Male; D010973:Platelet Adhesiveness / Q000187:drug effects; D010974:Platelet Aggregation / Q000187:drug effects; D011817:Rabbits; D013997:Time Factors; D014280:Triglycerides / Q000097:blood
D000090:Acetoacetates; D002087:Butyrates; D002210:Caprylates; D007657:Ketone Bodies; D014280:Triglycerides; D002784:Cholesterol