Xeonon accumulation in the red blood cell. A process latered by suppressors of the membrane active transport function.
Xenon passage across the erythrocyte membrane was investigated by performing several types of tests. The effects of some enzyme inhibitors (ouabain, NaF, dinitrophenol, low temperature), representing various modifications of the mentioned transport phenomenon, led to the conclusion of the existence of a strong correlation between the cellular energetic metabolism (and, hence, the energy supply for membrane processes) and the xenon accumulation into the erythrocyte. The experimental data obtained indicate that the xenon concentration in the cell water exceeds the concentration in the incubation solution by about 20%. The metabolic inhibitors practically equalise the xenon concentrations in the cell water and in the surrounding medium. The possible theoretical consequences of these facts are taken into account and analyzed.
D001693:Biological Transport, Active; D002118:Calcium / Q000378:metabolism; D002462:Cell Membrane / Q000187:drug effects / Q000378:metabolism*; D004912:Erythrocytes / Q000187:drug effects / Q000378:metabolism*; D006801:Humans; D007700:Kinetics; D008433:Mathematics; D010042:Ouabain / Q000494:pharmacology; D011188:Potassium / Q000378:metabolism; D013696:Temperature; D013997:Time Factors; D014978:Xenon / Q000097:blood*
D014978:Xenon; D010042:Ouabain; D011188:Potassium; D002118:Calcium