Therapeutic use of inducers of interferon on Herpes simplex keratitis in humans.
The double-stranded RNA interferon inducer polyinosinic-polycytidylic acid (In-Cn) was used to treat acute dendritic keratitis in man in a double-blind manner with IDU. The success rate for this agent was similar to IDU and was found efficacious in cases not responsive to IDU. Prophylaxis with In-Cn did not prevent recurrences of epithelial herpes, but such recurrences were responsive to IDU or In-Cn.
D000208:Acute Disease; D002908:Chronic Disease; D002986:Clinical Trials as Topic; D006801:Humans; D007065:Idoxuridine / Q000627:therapeutic use*; D007369:Interferon Inducers / Q000627:therapeutic use*; D007635:Keratitis, Dendritic / Q000188:drug therapy*; D011070:Poly I-C / Q000627:therapeutic use*; D012008:Recurrence
D007369:Interferon Inducers; D007065:Idoxuridine; D011070:Poly I-C