Tricyclic antidepressive drugs and dopamine-sensitive adenylate cyclase from rat brain striatum.
Tricyclic antidepressant drugs were examined as inhibitors of dopamine-sensitive adenylate cyclase in a cell-free homogenate of rat brain striatum. Amitriptyline (Ki 0.17 muM) and doxepin (Ki 0.24 muM) were found to be potent inhibitors of dopamine-sensitive adenylate cyclase, chlorimipramine (Ki 0.59 muM) and nortriptyline (Ki 0.50 muM) were moderate inhibitors and imipramine, desmethylimipramine, protriptyline and melitracene were weak inhibitors with Ki values higher than 1 muM.
D000067956:Adenylyl Cyclase Inhibitors; D000818:Animals; D000929:Antidepressive Agents, Tricyclic / Q000494:pharmacology*; D002474:Cell-Free System; D003342:Corpus Striatum / Q000201:enzymology*; D004298:Dopamine / Q000494:pharmacology*; D066298:In Vitro Techniques; D010761:Phosphorus Radioisotopes; D051381:Rats; D013268:Stimulation, Chemical; D014149:Tranquilizing Agents / Q000494:pharmacology
D000067956:Adenylyl Cyclase Inhibitors; D000929:Antidepressive Agents, Tricyclic; D010761:Phosphorus Radioisotopes; D014149:Tranquilizing Agents; D004298:Dopamine