title: Prostaglandin E2 on the electroencephalogram.
abstract: Present study was prompted by the report from another center on the occasional occurrence of convulsions and abnormal electroencephalogram (E.E.G.) patterns in women aborted with intra-amniotic prostaglandin F2alpha (PGF2alpha). Fifty four subjects were investigated by means of an E.E.G. taken before and after initiation of PGE2 administration. They included pregnant and non-pregnant patients, nearly half (23) of whom were known epileptics. One seizure was observed during PG administration in a man with daily psychomotor attacks who had not taken his anticonvulsants on the day the test was performed. PGE2 caused no alteration of the E.E.G. in subjects with a normal control tracing; in those with an abnormal E.E.G., a deterioration was seen in one and an improvement in three. It is concluded that PGE2 is not epileptogenic at doses required for termination of pregnancy.
mesh_terms: D000028:Abortion, Induced; D000328:Adult; D000650:Amnion; D002540:Cerebral Cortex / Q000187:drug effects*; D002986:Clinical Trials as Topic; D004569:Electroencephalography; D004827:Epilepsy / Q000503:physiopathology; D005260:Female; D006801:Humans; D007267:Injections; D007275:Injections, Intravenous; D008297:Male; D011247:Pregnancy; D011262:Pregnancy Trimester, Second; D011263:Pregnancy Trimester, Third; D011458:Prostaglandins E / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D014599:Uterus
chemical_list: D011458:Prostaglandins E