title: Chemotactic deactivation of human eosinophils by the eosinophil chemotactic factor of anaphylaxis (38527).
abstract: Purified human eosinophils demonstrate diminished chemotactic responsiveness (deactivation) after incubation with the eosinophil chemotactic factor of anaphylaxis (ECF-A). The deactivation is rapid and selective in that ECF-A deactivated human eosinophils more markedly than neutrophilic or mononuclear leukocytes. The eosinophil can also be deactivated by C5a which is eosinophilotactic, and there is cross deactivation between C5a and ECF-A. Deactivation may be an important physiologic control mechanism enabling the eosinophil to remain at sites of ECF-A release in order to manifest its regulatory functions in immediate hypersensitivity reactions.
mesh_terms: D000707:Anaphylaxis / Q000276:immunology*; D002245:Carbon Dioxide / Q000378:metabolism; D002633:Chemotaxis; D003165:Complement System Proteins; D004804:Eosinophils / Q000276:immunology*; D005947:Glucose / Q000378:metabolism; D006801:Humans; D009000:Monocytes / Q000276:immunology; D009504:Neutrophils / Q000276:immunology; D010455:Peptides / Q000276:immunology*
chemical_list: D010455:Peptides; D002245:Carbon Dioxide; D003165:Complement System Proteins; D005947:Glucose