Charlotte Auerbach and chemical mutagenesis.
A review is presented of the many conceptual contributions of Charlotte Auerbach to the development of the field of chemical mutagenesis during the past thirty years. The following aspects are discussed: (1) differences between the genetic effects of chemicals and X-rays; (2) mosaicism, delayed mutation and replicating instabilities; (3) mutation as a cellular process; (4) specificity; (5) dose-effect curves, and (6) correlation between different kinds of damage.
D004305:Dose-Response Relationship, Drug; D005260:Female; D005804:Genes, Lethal; D008040:Genetic Linkage; D005823:Genetics / Q000266:history; D049673:History, 20th Century; D006801:Humans; D009030:Mosaicism; D009153:Mutagens; D009154:Mutation; D012730:Sex Chromosomes; D013045:Species Specificity
D009153:Mutagens