title: The synthesis of tautine from sulfate VIII. The effect of potassium (38580).
abstract: The in vitro and in vivo influence of K+ on the activity of rat heart and liver PAPS-sulfotransferase (P1) was tested. The P1 activity was optimal with 0.5 mumoles K+ per mug protein. The P1 activity was decreased by mild dialysis and lost by extended dialysis. The enzyme was stable when dialyzed with K+ and tests with other ions indicated K+ specificity. Rats fed purified diets with low, normal or high levels of K+ had significantly different heart taurine concentrations and P1 specific activities. These P1 specific activities became comparable to those from the rats receiving the normal K+ diet by the addition of KCl to the assay mixture.
mesh_terms: D000818:Animals; D066298:In Vitro Techniques; D008099:Liver / Q000378:metabolism*; D008297:Male; D009206:Myocardium / Q000378:metabolism*; D011188:Potassium / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D013431:Sulfates / Q000378:metabolism*; D013466:Sulfurtransferases / Q000378:metabolism; D013654:Taurine / Q000096:biosynthesis*
chemical_list: D013431:Sulfates; D013654:Taurine; D013466:Sulfurtransferases; D011188:Potassium