title: Structure-activity relationships for antimicrobial cephalosporins.
abstract: The antimicrobial activity of a series of 7-mandelamido-3-cephem-4-carboxylic acids was studied using the Free-Wilson method. Electron-withdrawing and lipophilic properties of the substituents are shown to play an important role in the activity.
mesh_terms: D002511:Cephalosporins / Q000494:pharmacology*; D055598:Chemical Phenomena; D002621:Chemistry; D008826:Microbial Sensitivity Tests; D008954:Models, Biological; D012044:Regression Analysis; D013329:Structure-Activity Relationship
chemical_list: D002511:Cephalosporins