title: [Immuno-prevention of coli infections in swine using live vaccine. 1. Use in coli infections during the 1st days of life].
abstract: Live vaccine prepared from streptomycin-dependent mutants of E. coli was well tolerated in various doses and at various times of administration, for there were no adverse reactions. There was no evidence of reversion to a virulent form. Efficacy was closely related to frequency of application of the vaccine. Vaccination must be performed as early as possible to immunize against infection during the first few days of life. It was possible to confer protection against the diarrhoea that occurs at 3-4 weeks of age. The use of an oral vaccine under intensive husbandry systems was shown to be safe. When the piglets were kept in cages, the vaccine could be administered in the existing mixing tanks for water supply, without the need for special equipment. Oral immunization of pigs already infected or already ill did not aggravate the existing infection, whether the animals were housed individually or in pens. Because of the dilution effect of the mixing tank and water supply pipes, the dose of vaccine, given on ten successive days, should be calculated at 10(9) organisms of the E. coli mutant per animal. This should supply a number close to the desired bacterial count of 10(10) organisms per animal daily. Immunization significantly reduced the frequency of gastrointestinal diseases during the first three weeks of age in piglets.
mesh_terms: D000818:Animals; D001428:Bacterial Vaccines / Q000008:administration & dosage*; D004927:Escherichia coli Infections / Q000188:drug therapy / Q000517:prevention & control / Q000662:veterinary*; D007167:Immunotherapy / Q000662:veterinary; D013552:Swine; D013553:Swine Diseases / Q000188:drug therapy* / Q000276:immunology; D014613:Vaccines, Attenuated / Q000008:administration & dosage*
chemical_list: D001428:Bacterial Vaccines; D014613:Vaccines, Attenuated
vernacular_title: Zur Immunprophylaxe der Koliinfektionen bei Schweinen mit Lebendimpfstoff. 1. Anwendung bei Koliinfektionen der ersten Lebenstage