Progressive hypovolemia leading to shock after continuous hemorrhage and 3:1 crystalloid replacement.
Dogs subjected to arterial hemorrhage and infused with 3:1 volumes of lactated Ringer's solution became progressively hypovolemic, to the point of frank shock. Stability and normovolemia were restored only after additional fluid delivery, in a net ratio of 8:1. These were the mathematically predicted values that satisfied Starling's hypothesis.
D000818:Animals; D001810:Blood Volume / Q000187:drug effects; D004285:Dogs; D005260:Female; D006439:Hemodynamics / Q000187:drug effects; D006470:Hemorrhage / Q000628:therapy*; D008297:Male; D010952:Plasma Substitutes / Q000008:administration & dosage* / Q000494:pharmacology; D010953:Plasma Volume / Q000187:drug effects; D012769:Shock / Q000517:prevention & control*; D014882:Water-Electrolyte Balance
D010952:Plasma Substitutes