[The reaction of the supraoptic nucleus of the hypothalamus and diuresis during thyroid gland restitution following discontinuation of 6-methylthiouracil].
There is a marked reduction of diuresis (revealed by water load) during the action of 6-methylthiouracil (MTU). In the course of the thyroid gland restitution (after the discontinuance of the 6-MTU action) the diuresis at first becomes intensified and then it repeatedly either becomes diminished or enhanced. Secretory activity of the cells of the supraoptic nucleus of the anterior hypothalamus also becomes alternately enhanced and diminished. Dynamics of the shifts in this activity failed to correlate with the "ricochet" enhancement of the thyrotropic function of the hypophysis, which occurred on the 11th restitution day and corresponded to the "ricochet" enhancement of iodine consumption by the thyroid gland. Thus, there was no association between the state of the cells of the supraoptic nucleus and the changes in the thyrotropic function of the hypophysis.
D000818:Animals; D004231:Diuresis / Q000187:drug effects*; D007031:Hypothalamus / Q000166:cytology*; D007455:Iodine / Q000378:metabolism; D007457:Iodine Radioisotopes; D008297:Male; D008779:Methylthiouracil / Q000494:pharmacology*; D051381:Rats; D013495:Supraoptic Nucleus / Q000166:cytology* / Q000187:drug effects; D013961:Thyroid Gland / Q000378:metabolism*; D013997:Time Factors
D007457:Iodine Radioisotopes; D007455:Iodine; D008779:Methylthiouracil
Reaktsiia supraopticheskogo iadra gipotalamusa i diurez vo vremia restitutsii shchitovidnoĭ zhelezy posle otmeny 6-metiltiouratsila