Intestinal metabolism of phenacetin in the rat: effect of charcoal-broiled beef and rat chow.
The intestinal metabolism of phenacetin in vitro was increased 1100 percent in rats fed charcoal-broiled ground beef in a semisynthetic diet. The intestinal metabolism of phenacetin was increased 200 percent in rats fed a chow diet, as compared to rats fed the semisynthetic diet. The results obtained suggest a need for studies in man to determine whether charcoal-broiled meat and other dietary constituents can stimulate the intestinal metabolism of phenacetin or other drugs and thereby decrease their absorption and bioavailability.
D000818:Animals; D002417:Cattle; D002606:Charcoal; D003296:Cooking; D004032:Diet; D007421:Intestine, Small / Q000378:metabolism*; D008297:Male; D008460:Meat; D010615:Phenacetin / Q000378:metabolism*; D051381:Rats
D002606:Charcoal; D010615:Phenacetin