Colchicine-induced inhibition of plasma lipoprotein lipase release in the intact rat.
The release of plasma lipoprotein lipase by heparin was studied in fed and food-deprived rats pretreated with colchicine and vinblastine. Four hours after the administration of either drug the lipoprotein lipase activity released by heparin was only half of that found in controls. Colchicine affected the release of both protamine-sensitive and protamine-resistant lipoprotein lipase. It is suggested that colchicine and vinblastine interfere with the transport of lipoprotein lipase from the site of its storage to the vascular cell surface.
D000818:Animals; D001692:Biological Transport / Q000187:drug effects; D003078:Colchicine / Q000494:pharmacology*; D004351:Drug Resistance; D006493:Heparin / Q000494:pharmacology; D008071:Lipoprotein Lipase / Q000097:blood*; D008099:Liver / Q000201:enzymology; D008297:Male; D011479:Protamines / Q000494:pharmacology; D051381:Rats; D013997:Time Factors; D014747:Vinblastine / Q000494:pharmacology*
D011479:Protamines; D014747:Vinblastine; D006493:Heparin; D008071:Lipoprotein Lipase; D003078:Colchicine