[An autoradiographic study of kidney tissue with different frequency of exposure to a pathogenic factor].
The kidney tissue was examined under normal conditions and also with a single and repeated administration of mercuric bichloride at intervals of 1 day and 1 week, autoradiographically with the use of thymidine-H3. Male albino mice (26) weighing 25-30 g were used in these experiments. Control mice displayed a relatively greater label index in the epithelium of the proximal tubules. With a more frequent action of the pathogenic factor on the kidney there proved to appear more DNA-synthesizing cells. It is supposed that the existing interrelationship between the number of labeled cells of the epithelium of the proximal tubules and of the flattened cells lying under their basal membranes served as a peculiar index of the regenerative manifestations in the tissue of the injured kidney.
D000818:Animals; D001345:Autoradiography; D004247:DNA / Q000096:biosynthesis*; D007668:Kidney / Q000166:cytology / Q000378:metabolism* / Q000503:physiopathology; D007686:Kidney Tubules, Distal / Q000166:cytology; D007687:Kidney Tubules, Proximal / Q000166:cytology; D008297:Male; D008630:Mercury Poisoning / Q000378:metabolism* / Q000503:physiopathology; D051379:Mice; D012038:Regeneration; D013936:Thymidine / Q000378:metabolism*; D014316:Tritium
D014316:Tritium; D004247:DNA; D013936:Thymidine
Avtoradiograficheskoe issledovanie pochechnoĭ tkani pri raznoĭ chastote deĭstviia patogennogo faktora