Atopic skin test re-evaluated. III. The wheal: flare ratio, the log-dose response curve and the bio-assay of allergen extracts.
It is demonstrated that the sum of the length and width of the flare is linearly correlated with the logarithm of the sum of the length and width of the wheal; on this basis a valuable "skin-reaction index" is proposed. Furthermore, the log-dose response curve of the skin reaction, at least in the medium-sized reactions, proved to be a straight line. These methods permit a bio-assay of allergens extracts giving a maximal dispersion of 100% above and below the exact value. Coefficient of variation: 62%.
D000485:Allergens; D001681:Biological Assay; D004305:Dose-Response Relationship, Drug; D006801:Humans; D008433:Mathematics; D006255:Rhinitis, Allergic, Seasonal / Q000276:immunology; D012882:Skin Tests
D000485:Allergens