[Effect of the antibiotic sibiromycin on the bioelectrical activity of the heart and the serum transaminase activity in dogs].
Experiments with dogs showed that daily intravenous administrations of sibiromycin in doses of 1.5 or 1 gamma/kg resulted in significant changes in the ECG: delayed heart rythm, narrowed R peak amplitude, lower P peak or its absence, presence of coronary T peak and location of S-T segment above the isoline, which corresponded to the increase in the transminase activity of the blood serum. When sibiromycin was used in a dose of 0.75 gamma/kg 30 times a day and in a dose of 1.5 gamma/kg 2 times a weak for 13 times T, P R peaks on the ECG changed. The cardiotoxic effect of sibiromycin depended on the dose. When used in a single dose of 5 gamma/kg, in a dose of 0.37 gamma/kg 30 times a day or in a dose of 2 or 1.5 gamma/kg once a weak for 7 times, sibiromycin had no toxic effect on the heart.
D000410:Alanine Transaminase / Q000097:blood; D000818:Animals; D000903:Antibiotics, Antineoplastic / Q000494:pharmacology*; D001219:Aspartate Aminotransferases / Q000097:blood; D003124:Colorimetry; D004285:Dogs; D004305:Dose-Response Relationship, Drug; D004562:Electrocardiography; D004594:Electrophysiology; D006321:Heart / Q000187:drug effects* / Q000502:physiology; D006339:Heart Rate / Q000187:drug effects; D007275:Injections, Intravenous; D012770:Shock, Cardiogenic / Q000139:chemically induced; D013997:Time Factors; D000637:Transaminases / Q000097:blood*
D000903:Antibiotics, Antineoplastic; D000637:Transaminases; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase
Vliianie antibiotika sibiromitsina na bioélektricheskuiu aktivnost' serdtsa i transaminaznuiu aktivnost' syvorotki krovi sobak