title: Permanent neonatal diabetes mellitus: a case report with plasma insulin studies.
abstract: The 11th case of permanent neonatal diabetes mellitus appearing during the first month of life is reported. A critical review of the literature is also presented. The permanence of diabetes is demonstrated by the duration of insulin therapy still necessary after 30 months. Insulin-stimulation tests have been performed some for the first time in such a young diabetic. They have shown a nearly total failure in beta-cell response, only very high doses of glucagon provoking a moderate insulin secretion. The absence of acetonuria is discussed. It can perhaps be explained by the hyperglycemia which, by a mass effect, brings about cellular glucose penetration and this stops liberation of Nefa's from adipose tissue.
mesh_terms: D001786:Blood Glucose / Q000032:analysis; D002908:Chronic Disease; D003920:Diabetes Mellitus / Q000097:blood / Q000175:diagnosis*; D004361:Drug Tolerance; D005934:Glucagon; D005951:Glucose Tolerance Test; D006801:Humans; D006943:Hyperglycemia / Q000175:diagnosis; D007231:Infant, Newborn; D007232:Infant, Newborn, Diseases / Q000097:blood / Q000175:diagnosis; D007328:Insulin / Q000097:blood; D008297:Male; D014044:Tolbutamide
chemical_list: D001786:Blood Glucose; D007328:Insulin; D005934:Glucagon; D014044:Tolbutamide