title: Glucose-6-phosphate dehydrogenase deficiency and blood transfusion.
abstract: Seven White American male blood donors with Italian surnames were found to have red cell glucose-6-phosphate dehydrogenase (G-6-PD) deficiency among 1,285 with Greek or Italian surnames screened. Five different genetic variants were found; G-6-PDs Mediterranean (2), "Athens-like" (2), San Juan, Columbus and "Canton-like". Clinical evaluation of 23 patients who received 24 units of G-6-PD-deficient blood (G-6-PD A-) failed to reveal any deleterious effects. Screening of Black donors for G-6-PD deficiency is believed unnecessary; further data are needed before a recommendation can be made concerning screening for non-Black donors.
mesh_terms: D044383:Black People; D001782:Blood Donors; D001803:Blood Transfusion; D003237:Connecticut; D004219:District of Columbia; D005954:Glucosephosphate Dehydrogenase / Q000145:classification; D005955:Glucosephosphate Dehydrogenase Deficiency; D006461:Hemolysis; D006801:Humans; D007558:Italy; D008297:Male; D012156:Reticulocytes; D044465:White People; D001741:Black or African American
chemical_list: D005954:Glucosephosphate Dehydrogenase