title: Alkaloids of Vinca species V: structure elucidation of herbadine, an alkaloid isolated from Vinca libanotica.
abstract: Herbadine, a novel dihydroindole alkaloid, was isolated from the arterial parts of Vinca libanotica Zucc. (Apocynaceae). The physical and spectral data (UV, IR, NMR, and mass spectroscopy) indicated the alkaloid to be a derivative of aimaline. Comparative high-resolution NMR studies with quebrachidine and high-resolution mass spectral studies established the structure of the alkaloid to be 2-epi-3-hydroxyquebrachidine. Herbadine was previously isolated from another species by Russian workers and a structure was postulated. The current paper gives evidence for a corrected structure of herbadine.
mesh_terms: D000404:Ajmaline / Q000031:analogs & derivatives* / Q000032:analysis; D007211:Indoles / Q000032:analysis; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D013055:Spectrophotometry, Infrared; D013056:Spectrophotometry, Ultraviolet; D014748:Vinca Alkaloids / Q000032:analysis*
chemical_list: D007211:Indoles; D014748:Vinca Alkaloids; D000404:Ajmaline; C010318:quebrachidine