Luteinizing hormone-releasing hormone versus human chorionic gonadotropin: differential effect on the development of ovulatory refractoriness and antibodies.
Cyclic intramuscular injections of 25 IU of human chorionic gonadotropin (HCG) at 3-week intervals induced ovulatory refractoriness and HCG antibodies after five to eight treatment cycles. Two of fifty rabbits failed to ovulate following two successive injections of luteinizing hormone-releasing hormone (LH-RH); however, no LH-RH antibodies were detected in the sera of these two animals, suggesting that these observations were due to chance alone. Thus, 0.5 mug of LH-RH injected intramuscularly at 3-week intervals did not induce ovulatory refractoriness or antibody formation after as many as 18 successive treatment cycles.
D000818:Animals; D000917:Antibody Formation; D000918:Antibody Specificity; D006063:Chorionic Gonadotropin / Q000008:administration & dosage / Q000276:immunology / Q000494:pharmacology*; D005260:Female; D007987:Gonadotropin-Releasing Hormone / Q000008:administration & dosage / Q000276:immunology / Q000494:pharmacology*; D006801:Humans; D009500:Neutralization Tests; D010060:Ovulation / Q000187:drug effects*; D011817:Rabbits
D006063:Chorionic Gonadotropin; D007987:Gonadotropin-Releasing Hormone