Histidines and renal function.
The results of endogenous renal clearances of 3-methylhistidine and histidine in twelve patients with normal and decreased renal functions are reported. Differences in the renal handling of the amino acids have been established. 3-methylhistidine showed a hyperbolic relationship between serum concentration and inulin clearance: histidine a linear relationship. The percentage tubular reabsorption of 3-methylhistidine was found to be about half that of histidine. The possible use of the measurement of serum 3-methylhistidine concentration as an index of renal insufficiency is discussed.
D000328:Adult; D000368:Aged; D003404:Creatinine / Q000097:blood; D005260:Female; D005921:Glomerulonephritis / Q000378:metabolism; D006639:Histidine / Q000097:blood / Q000378:metabolism*; D006801:Humans; D006977:Hypertension, Renal / Q000378:metabolism; D007444:Inulin; D007668:Kidney / Q000378:metabolism* / Q000502:physiology; D007677:Kidney Function Tests; D008297:Male; D008657:Metabolic Clearance Rate; D008762:Methylhistidines / Q000097:blood / Q000378:metabolism; D008875:Middle Aged; D011704:Pyelonephritis / Q000378:metabolism
D008762:Methylhistidines; D006639:Histidine; D007444:Inulin; D003404:Creatinine