Polymorphonulcear leukocyte chemotaxis toward oxidized lipid components of cell membranes.
Polymorphonuclear leukocyte chemotaxis has been elicited by oxidized arachidonic acid and other oxidized polyenoic lipids in the Boyden micropore filter assay system. This chemotactic activity was observed in the absence of serum and chemotactic proteins. The esterfied arachidonic acid present in plasma membranes may be a precursor of chemotactic messages as well as prostaglandins in vivo.
D001095:Arachidonic Acids / Q000378:metabolism; D002462:Cell Membrane / Q000378:metabolism; D002633:Chemotaxis; D005231:Fatty Acids, Unsaturated / Q000378:metabolism; D006801:Humans; D008041:Linoleic Acids / Q000378:metabolism; D050356:Lipid Metabolism; D008055:Lipids; D009504:Neutrophils / Q000502:physiology*; D010084:Oxidation-Reduction
D001095:Arachidonic Acids; D005231:Fatty Acids, Unsaturated; D008041:Linoleic Acids; D008055:Lipids