Topical treatment with urea-hydrocortisone in atopic dermatitis. A controlled study against betamethasone 17-valerate.
When comparing 1% hydrocortisone in a stabilized 10% urea cream with 0.1% betamethasone 17-valerate cream in a double-blind study on 49 patients with atopic dermatitis or atopic winter feet, betamethasone cream was found to be the most potent. The study also showed that in approximately 60% of the patients the clinical response was equal. It is suggested that the urea-hydrocortisone combination may have its place in the long-term topical treatment of atopic dermatitis on account of its water-binding effect.
D000287:Administration, Topical; D000893:Anti-Inflammatory Agents / Q000009:adverse effects / Q000627:therapeutic use*; D001623:Betamethasone / Q000031:analogs & derivatives*; D001624:Betamethasone Valerate / Q000627:therapeutic use*; D002057:Burns, Chemical / Q000209:etiology; D002986:Clinical Trials as Topic; D003876:Dermatitis, Atopic / Q000188:drug therapy*; D004338:Drug Combinations; D004890:Erythema / Q000139:chemically induced; D006801:Humans; D006854:Hydrocortisone; D013997:Time Factors; D014508:Urea / Q000009:adverse effects / Q000627:therapeutic use*
D000893:Anti-Inflammatory Agents; D004338:Drug Combinations; D014508:Urea; D001623:Betamethasone; D001624:Betamethasone Valerate; D006854:Hydrocortisone