Cholinergic-dopaminergic interaction in the striatum: the effect of 6-hydroxydopamine or pimozide treatment on the increased striatal acetylcholine levels induced by apomorphine, piribedil and d-amphetamine.
Apomorphine (1 and 2 mg/kg), piribedil (15 and 60 mg/kg) and d-amphetamine (5 and 10 mg/kg) increased rat striatal acetylcholine levels without affecting choline. Pretreatment with pimozide (0.5 mg/kg) completely antagonized the effect of apomorphine and piribedil and by itself markedly decreased striatal acetylcholine levels. d-Amphetamine signigicantly antagonized the effect of pimozide. Nine days after pretreatment with 6-hydroxydopamine plus pargyline, striatal dopamine was decreased by 78% while acetylcholine and choline levels remained unaltered. Under these conditions, the effect of d-amphetamine was completely abolished while apomorphine and piribedil were just as active as in the vehicle-treated group. The results suggest that d-amphetamine acted indirectly to increase striatal acetylcholine levels probably through the release of dopamine and/or noradrenaline, while apomorphine and piribedil acted directly at dopamine receptor sites.
D000109:Acetylcholine / Q000378:metabolism*; D000661:Amphetamine / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D000818:Animals; D001058:Apomorphine / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D002794:Choline / Q000378:metabolism; D003342:Corpus Striatum / Q000187:drug effects* / Q000378:metabolism; D004298:Dopamine / Q000378:metabolism; D005260:Female; D006892:Hydroxydopamines / Q000494:pharmacology*; D010293:Pargyline / Q000494:pharmacology; D010868:Pimozide / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D011719:Pyrazines / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D051381:Rats
D006892:Hydroxydopamines; D011719:Pyrazines; D010868:Pimozide; D010293:Pargyline; D000661:Amphetamine; D001058:Apomorphine; D002794:Choline; D000109:Acetylcholine; D004298:Dopamine