Effect of alpha-retinyl acetate on growth of hamsters fed vitamin A-deficient diets.
The capacity of the alpha-isomer of retinyl acetate to support growth in hamsters fed a vitamin A-deficient diet was assessed over a 40-fold dose range. Although decreased relative potency of the alpha isomer, as compared with the beta isomer, was found, sustained weight gain and survival for 6 months were achieved with a weekly intraperitoneal dose of 300 mug of the alpha isomer. An intraperitoneal dosage of alpha-retinyl acetate resulted in greater activity than an oral dosage.
D000085:Acetates / Q000494:pharmacology; D000284:Administration, Oral; D000824:Animal Nutritional Physiological Phenomena; D000818:Animals; D001835:Body Weight / Q000187:drug effects; D006224:Cricetinae; D007274:Injections, Intraperitoneal; D007536:Isomerism; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D013329:Structure-Activity Relationship; D014801:Vitamin A / Q000031:analogs & derivatives* / Q000494:pharmacology; D014802:Vitamin A Deficiency / Q000188:drug therapy*
D000085:Acetates; D014801:Vitamin A