title: Latent period, time to reach maximum effect, and disappearance of uterine contractility induced by desamino-oxytocin.
abstract: The effect of buccal desamino-oxytocin (CAO) upon uterine contractility was studied in pregnant women at term by recording the amniotic pressure. The DAO increased uterine activity and the intensity and frequency of the contractions; basal pressure did not vary. The time required to reach the maximum effect ranged between 57 and 106 minutes, whereas the time elapsed between the administration of the first tablet and the beginning of the increase of uterine activity ranged between 13 and 96 minutes. An inverse linear correlation between the percentage increase of uterine activity and the spontaneous uterine activity was observed. Ninety minutes after the suppression of DAO uterine activity remained above basal levels; uterine activity after DAO was found to be in direct linear correlation with stabilized utertine activity during DAO.
mesh_terms: D005260:Female; D006801:Humans; D007743:Labor, Obstetric; D010121:Oxytocin / Q000031:analogs & derivatives* / Q000494:pharmacology; D011247:Pregnancy; D013997:Time Factors; D014599:Uterus / Q000187:drug effects*
chemical_list: D010121:Oxytocin