Identification of angiotensinogenic hypertension in man using 1-sar-8-ala-angiotensin II (Saralasin, P-113).
Peripheral plasma renin activity (PRA) is not invariably elevated in patients whose ischemic renal lesion is causing hypertension. Infusions of an angiotensin II antagonist, 1-sar-8-ala-angiotensin II (P-113), have been used to determine whether the blood pressure responses might indicate angiotensin dependence in 221 consecutive hypertensive patients. In 32 patients P-113 infusion reversibly reduced blood pressure, and almost all of these "P-113 responders" had elevated renal vein and/or peripheral PRA levels, together with evidence of renal ischemia. Among the 189 "P-113 nonresponders," peripheral PRA was elevated in seven (3.8%), and renal vein PRA ratio was abnormal in two patients, who might represent exceptions to the otherwise successful record of the P-113 response in identifying "angiotensinoginic" hypertensives.
D000328:Adult; D000368:Aged; D000792:Angiography; D000804:Angiotensin II / Q000031:analogs & derivatives* / Q000096:biosynthesis; D001794:Blood Pressure / Q000187:drug effects; D006801:Humans; D006973:Hypertension / Q000097:blood / Q000175:diagnosis* / Q000209:etiology; D007511:Ischemia / Q000503:physiopathology; D007668:Kidney / Q000098:blood supply; D008875:Middle Aged; D009392:Nephrectomy; D011866:Radioisotope Renography; D012039:Regional Blood Flow; D012082:Renal Veins; D012083:Renin / Q000097:blood; D012504:Saralasin / Q000494:pharmacology; D014567:Urography
D000804:Angiotensin II; D012083:Renin; D012504:Saralasin