Effects of succinylcholine and d-tubocurarine on epinephrine-induced arrhythmias during halothane anesthesia in dogs.
The effects of subparalytic doses of succinylcholine and d-tubocurarine on epinephrine-induced cardiac arrhythmias during halothane anesthesia were evaluated in dogs. Succinylcholine markedly increased (P is less than .05) the arrhythmogenicity of epinephrine and d-tubocurarine slightly decreased (P is less than .05) its arrhythmic effect. Prior administration of atropine resulted in a partial, but significant, reversal of this action of succinylcholine.
D000769:Anesthesia, Inhalation; D000818:Animals; D001145:Arrhythmias, Cardiac / Q000139:chemically induced*; D001285:Atropine / Q000494:pharmacology; D002849:Chromatography, Gas; D004285:Dogs; D004837:Epinephrine / Q000008:administration & dosage / Q000494:pharmacology; D006221:Halothane; D006339:Heart Rate / Q000187:drug effects; D008297:Male; D013390:Succinylcholine / Q000494:pharmacology*; D014403:Tubocurarine / Q000494:pharmacology*
D001285:Atropine; D013390:Succinylcholine; D006221:Halothane; D014403:Tubocurarine; D004837:Epinephrine