Appparent familial multiple sclerosis in three generations. Report of a family with histocompatibility antigen typing.
Three members of an unusual family were affected with apparent multiple sclerosis in a direct line over three successive generations. Each affected member had clinical remissions and exacerbations and evidence of lesions disseminated in space. One affected member had a cerebrospinal fluid pleocytosis and elevated gamma-globulin level. The genetically determined histocompatibility antigen (HL-A) types are reported for 13 family members. The three affected members had HL-A types 11 and W16 in common.
D000293:Adolescent; D000328:Adult; D002555:Cerebrospinal Fluid / Q000166:cytology; D005260:Female; D005684:Gait; D006649:Histocompatibility Antigens; D006801:Humans; D007074:Immunoglobulin G / Q000134:cerebrospinal fluid; D008214:Lymphocytes; D008297:Male; D009103:Multiple Sclerosis / Q000134:cerebrospinal fluid / Q000175:diagnosis / Q000235:genetics*; D010375:Pedigree
D006649:Histocompatibility Antigens; D007074:Immunoglobulin G