[Effect of large doses of nicotinic acid on certain metabolic processes and contractile function of an intact heart].
Peroral administration of nicotinic acid to rabbits in amounts of 500 mg, twice a day for 7 days was attended by a reduced contractility of the myocardium, an increased content of catecholamines in the heart and deranged lipids metabolism in the heart muscle. It is assumed that the contractility of the heart is largely determined by the state of the lipids metabolism and their utilization in the generation of energy.
D000284:Administration, Oral; D000818:Animals; D002395:Catecholamines / Q000378:metabolism; D004734:Energy Metabolism; D005230:Fatty Acids, Nonesterified / Q000378:metabolism; D006321:Heart / Q000187:drug effects* / Q000502:physiology; D008297:Male; D009119:Muscle Contraction; D009206:Myocardium / Q000378:metabolism*; D009539:Nicotinic Acids / Q000008:administration & dosage / Q000494:pharmacology*; D011817:Rabbits
D002395:Catecholamines; D005230:Fatty Acids, Nonesterified; D009539:Nicotinic Acids
Vliianie bol'shikh doz nikotinovoĭ kisloty na nekotorye obmennye protsessy i sokratitel'nuiu funktsiiu intaktnogo serdtsa