Transient, spontaneous bruising with long bleeding time and normal platelet count.
Spontaneous, widespread bruising in apparently healthy individuals relatively common among Thai children. It is a transient problem, unaccompanied by any common bleeding disorder of childhood. The physical defect is limited to the painless cutaneous lesions. Screening tests for hemostasis as well as tests of platelet function were measured in 24 of these patients. The significant abnormal findings were eosinophilia, prolonged bleeding time, positive tourniquet test and platelet dysfunction--i.e., defective ADP release and adhesivity to glass beads. So far, the condition appears to 0e a self-limited diathesis of unknown etiology.
D000244:Adenosine Diphosphate / Q000096:biosynthesis; D000293:Adolescent; D001772:Blood Cell Count; D001779:Blood Coagulation Factors / Q000096:biosynthesis; D001780:Blood Coagulation Tests; D001792:Blood Platelets; D002648:Child; D002675:Child, Preschool; D003094:Collagen / Q000494:pharmacology; D004438:Ecchymosis / Q000209:etiology*; D005260:Female; D005898:Glass; D006454:Hemoglobins / Q000032:analysis; D006801:Humans; D007223:Infant; D008297:Male; D010973:Platelet Adhesiveness / Q000187:drug effects; D010974:Platelet Aggregation / Q000187:drug effects; D011517:Prothrombin Time; D013917:Thrombin / Q000494:pharmacology
D001779:Blood Coagulation Factors; D006454:Hemoglobins; D000244:Adenosine Diphosphate; D003094:Collagen; D013917:Thrombin