title: The effect of bithionol sulphoxide on Echinococcus granulosus and Taenia hydatigena infections in dogs.
abstract: Trials with bithionol sulphoxide involving 130 dogs, infected with either Echinococcus granulosus or Taenia hydatigena, indicated that a single treatment at a dose rate of 400 mg/kg or two treatments at 50 mg/kg eliminated the former, but a single treatment at 50 mg/kg was sufficient to eliminate the latter. Dose rates 200 mg/kg or more were lethal to some dogs. With two doses of 50 mg/kg, there was only minor discomfort from vomiting or diarrhoea in some dogs.
mesh_terms: D000818:Animals; D000871:Anthelmintics / Q000009:adverse effects / Q000627:therapeutic use*; D003967:Diarrhea / Q000662:veterinary; D004283:Dog Diseases / Q000139:chemically induced / Q000188:drug therapy* / Q000469:parasitology; D004285:Dogs; D004443:Echinococcosis / Q000188:drug therapy / Q000469:parasitology / Q000662:veterinary*; D010636:Phenols / Q000627:therapeutic use*; D013454:Sulfoxides / Q000627:therapeutic use; D013622:Taeniasis / Q000188:drug therapy / Q000469:parasitology / Q000662:veterinary*; D014839:Vomiting / Q000662:veterinary
chemical_list: D000871:Anthelmintics; D010636:Phenols; D013454:Sulfoxides