title: The effect of X-irradiation on the alanine--and aspartate aminotransferase activity in the liver, kidney and spleen of mouse.
abstract: The effect of X-irradiation on the alanine- and aspartate aminotransferase activity in the liver, kidney and spleen of mouse. Acta Physiol. Pol. 1975, 26 (1): 95-101. The alanine- and aspartate aminotransferase (GOT and GPT) activities and the protein content were measured in the liver, kidney and spleen homogenates of mice exposed to a single whole body X-irradiation with a 900 r dose. The assays were performed in 6 h intervals during the first day and 24 h intervals from the 2nd until the 6th day after the exposure. Significant differences in the enzymatic activity were found in the course of 24 h in control animals and a marked increase of this activity was found after irradiation. This may be explained by changes in the permeability of the mitochondrial membrane for enzyme molecules.
mesh_terms: D000410:Alanine Transaminase / Q000378:metabolism*; D000818:Animals; D001219:Aspartate Aminotransferases / Q000378:metabolism*; D002940:Circadian Rhythm; D005260:Female; D007668:Kidney / Q000201:enzymology* / Q000528:radiation effects; D008099:Liver / Q000201:enzymology* / Q000528:radiation effects; D008297:Male; D051379:Mice; D011829:Radiation Dosage; D011830:Radiation Effects; D013154:Spleen / Q000201:enzymology* / Q000528:radiation effects
chemical_list: D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase