title: Pharmacokinetics and metabolism of digoxin- and  beta-methyl-digoxin-12aplha-3 H in patients with acute hepatitis.
abstract: Pharmocokinetics and metabolism of digoxin and beta-methyldigoxin have been studied in patients with acute hepatits after intravenous administration of both H-labeled glycosides. In contrast to digoxin, the rate of decline of radioactivity after administration of beta-methyldigoxin was significantly retarded in patients with acute hepatitis. The increase in plasma concentration after beta-methyldigoxin to patients with acute hepatitis is probably related to decreased demethylation.
mesh_terms: D000208:Acute Disease; D000328:Adult; D000368:Aged; D002855:Chromatography, Thin Layer; D004077:Digoxin / Q000009:adverse effects / Q000031:analogs & derivatives / Q000097:blood / Q000378:metabolism*; D005260:Female; D006505:Hepatitis / Q000378:metabolism*; D006801:Humans; D007700:Kinetics; D008297:Male; D008745:Methylation; D008875:Middle Aged
chemical_list: D004077:Digoxin