title: [Osteoporosis and osteomalacia].
abstract: The pathogenesis, clinical course and treatment of senile-postmenopausal osteoporosis are reviewed. It is likely that several factors, including genetic and racial determinants as well as nutritional calcium and/or vitamin D deficiency in the elderly play a pathogenic role. Available data are consistent with the possibility that the primary alteration of bone metabolism in senile-postmenopausal osteoporosis may be a decrease in de-novo bone formation below the level necessary to compensate for age-related bone loss. The second part of the study deals with the osteomalacia syndrome. The most common known causes of osteomalacia are vitamin D deficiency, especially secondary to malabsorption, and a defective vitamin D metabolism associated with chronic renal insufficiency or prolonged anticonvulsant therapy. The hypophosphatemic forms of osteomalacia may be induced by renal tubular dysfunction or by phosphate deficiency of other origin; in these disorders a pathogenic role of altered vitamin D metabolism has not yet been established.
mesh_terms: D000367:Age Factors; D000368:Aged; D001861:Bone Regeneration; D001862:Bone Resorption; D005260:Female; D006801:Humans; D008297:Male; D008593:Menopause; D010018:Osteomalacia / Q000175:diagnosis / Q000188:drug therapy / Q000209:etiology; D010024:Osteoporosis / Q000175:diagnosis / Q000188:drug therapy / Q000209:etiology; D010710:Phosphates / Q000172:deficiency; D012737:Sex Factors; D014807:Vitamin D / Q000627:therapeutic use; D014808:Vitamin D Deficiency / Q000150:complications
chemical_list: D010710:Phosphates; D014807:Vitamin D
vernacular_title: Osteoporose und Osteomalazie