[Relationship of the reticulo-plasmocytic reaction of the bone marrow and serum hypergammaglobulinemia when tetracycline is administered to rabbits].
Administration of tetracycline to rabbits in doses of 10 and 40 mg/kg induced hyperplasia of the reticulo-plasmic tissue of the bone marrow correlating with increased levels of gammaglobulins in the blood serum. The pronounced reticulo-plasmocytal reaction of the bone marrow must be considered as manifestation of hyperplasia of the whole reticulo-histiocytal system of the host with impairement of differentiation of the reticular syncytium of the bone marrow.
D000284:Administration, Oral; D000818:Animals; D001772:Blood Cell Count; D001797:Blood Protein Electrophoresis; D001853:Bone Marrow / Q000187:drug effects*; D001854:Bone Marrow Cells; D001856:Bone Marrow Examination; D004305:Dose-Response Relationship, Drug; D004590:Electrophoresis, Paper; D006942:Hypergammaglobulinemia / Q000139:chemically induced*; D008297:Male; D010950:Plasma Cells / Q000187:drug effects*; D011817:Rabbits; D013268:Stimulation, Chemical; D013752:Tetracycline / Q000494:pharmacology*; D013997:Time Factors
D013752:Tetracycline
O sviazi retikulo-plazmotsitarmnoĭ reaktsii kostnogo mozga i gipergammaglobulinemii syvorotki krovi pri vvedenii tetratsiklina krolikam