[The effect of hormones regulating calcium metabolism on the growth and metastasis of experimental tumors].
Injection of parathormone and thyrocalcitonin into rats with DMBA induced sarcomas resulted in a considerable stimulation of the metastasization process. It was found that the level of total Ca++ in tumor tissue was reduced under the influence of PTH. Under conditions of chronic exogenous hyperparathyroidism autoimmunereactions were suppressed. A prolonged administration of TCT did not alter considerable the total Ca++ content in tumor and markedly activated the autoantibody production in immunocompetent cells.
D000818:Animals; D000921:Antibody-Producing Cells; D002116:Calcitonin / Q000633:toxicity*; D002118:Calcium / Q000378:metabolism*; D004357:Drug Synergism; D006462:Hemolytic Plaque Technique; D007153:Immunologic Deficiency Syndromes / Q000139:chemically induced; D008099:Liver / Q000276:immunology; D008297:Male; D009132:Muscles / Q000032:analysis; D009362:Neoplasm Metastasis; D010281:Parathyroid Hormone / Q000633:toxicity*; D000644:Quaternary Ammonium Compounds; D051381:Rats; D012513:Sarcoma, Experimental / Q000032:analysis / Q000139:chemically induced* / Q000276:immunology; D013154:Spleen / Q000276:immunology
D010281:Parathyroid Hormone; D000644:Quaternary Ammonium Compounds; D002116:Calcitonin; D002118:Calcium
Vliianie gormonov, reguliruiushchikh obmen kal'tsiia, na rost i metastazirovanie opukholeĭ v éksperimente