Role of saline consumption in the prevention of deoxycorticosterone hypertension in rats by central 6-hydroxydopamine.
1. The mechanism by which pretreatment of rats with intracisternal 6-hydroxydopamine prevents the onset of deoxycorticosterone hypertension has been studied. 2. Rats pretreated with central 6-hydroxydopamine increase their consumption of 0-17 mol/l sodium chloride--0-03 mol/l potassium chloride ('saline') less than normal rats when implanted with deoxycorticosterone. 3. Intact rats restricted to the equivalent consumption of saline of rats pretreated with 6-hydroxydopamine develop hypertension despite this restriction. 4. It is suggested that the prevention of deoxycorticosterone hypertension by central 6-hydroxydopamine does not depend on reduced saline consumption.
D000818:Animals; D001794:Blood Pressure; D001921:Brain / Q000187:drug effects / Q000378:metabolism; D003900:Desoxycorticosterone; D004298:Dopamine / Q000378:metabolism; D004327:Drinking Behavior; D005247:Feeding Behavior; D006892:Hydroxydopamines / Q000494:pharmacology / Q000627:therapeutic use*; D006973:Hypertension / Q000139:chemically induced / Q000503:physiopathology / Q000517:prevention & control*; D008297:Male; D009638:Norepinephrine / Q000378:metabolism; D011189:Potassium Chloride / Q000627:therapeutic use*; D051381:Rats; D012965:Sodium Chloride / Q000627:therapeutic use*; D013997:Time Factors
D006892:Hydroxydopamines; D003900:Desoxycorticosterone; D012965:Sodium Chloride; D011189:Potassium Chloride; D004298:Dopamine; D009638:Norepinephrine