[Excitability curve of alpha motor neurons of the foot dorsal flexor in chemically induced parkinsonian rigidity prior to and following ethylbenzatropine administration].
For evaluation of the state of excitability of motoneurons in the dorsal flexor of the foot in patients with drug-induced muscle rigidity curves of excitability of motoneurons in the anterior tibial muscle were plotted in 10 patients not receiving psychotropic agents (controls) and 10 patients treated with chlorpromazine. Two variants of experiment wase used: in the 1st variant stimulation of the peroneal nerve  behind the fibular capitulum served as the conditioning and testing stimulus, in the 2nd variant stimulation of the tibial nerve in the popliteal fossa was the conditioning stimulus and stimulation of the peroneal nerve in the above way was the testing stimulus. The investigations were carried out before and 30-50 min after intramuscular injection of ethylbenzatropine 5 mg. In the 1st variant the curve of excitability of the motoneurons of the anterior tibial muscle showed the same configuration as the curve of excitability of motoneurons of the soleus muscle in the control group as well as in the treated group. Similarly as in the excitability curve of the soleus muscle five phases could be differentiated in it. Phase III of depression was, however, deeper and phase IV of returning excitability was more evident. In variant II in phase III depression was observed lasting only 40 msec., then in place of return of excitability its decrease was observed. These results were similar to these obtained in the case of conditioning stimulation of afferent fibres of the anterior tibialis muscle, and testing stimulation of the afferent fibres of the soleus muscle. After ethylbenzatropine injection no changes were found in variant I, on the other hand, in variant II a rise of excitability was present in phase III in the control group and in phases III and IV in treated patients. Ethylbenzatropine seemed, thus, to have no effect on the excitability of motoneurons in the dorsal flexor of the foot in the case of conditioning afferent stimulation of the dorsae flexor of the foot.
D002746:Chlorpromazine / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use; D004576:Electromyography; D005528:Foot / Q000294:innervation; D006181:H-Reflex / Q000187:drug effects; D006801:Humans; D007273:Injections, Intramuscular; D009046:Motor Neurons / Q000187:drug effects*; D009127:Muscle Rigidity / Q000503:physiopathology; D009132:Muscles / Q000187:drug effects; D010300:Parkinson Disease / Q000503:physiopathology; D010543:Peroneal Nerve; D010812:Physical Stimulation; D013979:Tibial Nerve; D013997:Time Factors; D014326:Tropanes / Q000008:administration & dosage / Q000494:pharmacology*
D014326:Tropanes; D002746:Chlorpromazine
Krzywa pobudliwości motoneuronów alfa mieśnia zginacza grzbietowego stopy w polekowej sztywności parkinsonowskiej przed i po podaniu etylobenzoatropiny