Prostaglandin F2-alpha for induction of midterm abortion: a comparative study.
The action of prostaglandin F2alpha (PGF2-alpha) to induce midterm abortion in rabbits, rats, hamsters, and mice using different methods and routes of administration was studied. Administration of PGF-alpha in a Silastic-PVP implant was more effective than was the parenteral injection at the same dose levels. The efficacy of PGF2alpha was optimum when deposited locally in the uterine lumen as a Silastic-PVP implant, a condition comparable to a continuous intra-amniotic or extra-amniotic administration of PGF2alpha in women. It is possible that the insertion of a Silastic-PVP implant into the uterine lumen results in a continuous PGF2alpha release and a high local PGF2alpha concentration which minimizes such factors as dilution and the short half life displayed in the general circulation. PGF2alpha contained in a Silastic-PVP implant and inserted into the uterine lumen may effectively induce abortion with a comparatively lower dose than that necessary for parenteral routes of administration.
D000028:Abortion, Induced / Q000379:methods; D000818:Animals; D006224:Cricetinae; D003692:Delayed-Action Preparations; D004305:Dose-Response Relationship, Drug; D005260:Female; D007263:Infusions, Parenteral; D007274:Injections, Intraperitoneal; D007279:Injections, Subcutaneous; D007743:Labor, Obstetric / Q000187:drug effects; D008297:Male; D011247:Pregnancy; D011453:Prostaglandins / Q000008:administration & dosage* / Q000494:pharmacology; D011817:Rabbits; D014599:Uterus / Q000187:drug effects
D003692:Delayed-Action Preparations; D011453:Prostaglandins