Prostaglandins and congeners. Synthesis of simplified prostaglandins. Inhibition of gastric acid secretion by 2-(omega-carboxyalkyl)-3-alkylcycloalkanones.
Simplified prostaglandin analogs were prepared and tested for inhibition of gastric acid secretion. An alkyl moiety of 1-8 carbon atoms was substituted for the C-13 to C-20 chain of the PG's. Analog variations included shortened and lengthened acid side chains, beta-oxidation blockage, beta-ketol, Falpha-hydroxyl, and cyclohexanone substitution. Maximal inhibitory activity was obtained with the shorter alkyl moieties.
D000818:Animals; D002849:Chromatography, Gas; D003517:Cyclopentanes / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000494:pharmacology; D003864:Depression, Chemical; D005750:Gastric Juice / Q000378:metabolism*; D005753:Gastric Mucosa / Q000378:metabolism; D008297:Male; D011453:Prostaglandins / Q000138:chemical synthesis* / Q000494:pharmacology; D011708:Pylorus / Q000502:physiology; D051381:Rats; D013237:Stereoisomerism
D003517:Cyclopentanes; D011453:Prostaglandins