Thromboembolic complications of oral contraceptive therapy.
During a ten-year period, 348 women were studied for a total of 5877 patient months for changes in hematologic parameters induced by oral contraceptives. Significant increases were observed in Factors I, II, VII, VIII, IX, X and plasminogen. Severe complications developed in four patients. All four had an abnormal blood coagulation profile, suggesting "hypercoagulability" before initiation of therapy. All four patients were of A or AB blood group. It appears from these data that hematologic workups may be useful in women who are about to embark on long-term oral contraceptive therapy.
D001772:Blood Cell Count; D001777:Blood Coagulation / Q000187:drug effects; D001779:Blood Coagulation Factors / Q000032:analysis; D001789:Blood Group Antigens; D001792:Blood Platelets / Q000187:drug effects; D003276:Contraceptives, Oral / Q000009:adverse effects*; D005260:Female; D005340:Fibrinogen / Q000032:analysis; D006801:Humans; D010958:Plasminogen / Q000032:analysis; D012164:Retinal Diseases / Q000139:chemically induced; D013923:Thromboembolism / Q000139:chemically induced*; D013924:Thrombophlebitis / Q000139:chemically induced; D013997:Time Factors
D001779:Blood Coagulation Factors; D001789:Blood Group Antigens; D003276:Contraceptives, Oral; D005340:Fibrinogen; D010958:Plasminogen