Inhalation carcinogenicity of alpha halo ethers. III. Lifetime and limited period inhalation studies with bis(chloromethyl)ether at 0.1 ppm.
Rats and hamsters were exposed to 0.1 ppm bis(chloromethyl)ether (BCME) six hours per day, five days per week throughout their lifetime. Additional groups of rats were given 10, 20, 40, 60, 80, and 100 exposures to 0.1 ppm BCME and then held until death. Forty cancers originating in the respiratory tract were found in the 200 rats involved in these studies. These included 14 cancers of the lung and 26 cancers of the nasal cavity. They occurred in dose-related fashion. A single undifferentiated carcinoma of the lung was seen in a hamster.
D000818:Animals; D002273:Carcinogens; D002294:Carcinoma, Squamous Cell / Q000139:chemically induced / Q000473:pathology; D006224:Cricetinae; D004305:Dose-Response Relationship, Drug; D004781:Environmental Exposure; D008175:Lung Neoplasms / Q000139:chemically induced / Q000473:pathology; D008297:Male; D008737:Methyl Chloride / Q000633:toxicity; D008738:Methyl Ethers / Q000633:toxicity*; D018241:Neuroectodermal Tumors, Primitive, Peripheral / Q000139:chemically induced / Q000473:pathology; D009669:Nose Neoplasms / Q000139:chemically induced / Q000473:pathology; D051381:Rats; D012142:Respiratory Tract Neoplasms / Q000139:chemically induced* / Q000473:pathology
D002273:Carcinogens; D008738:Methyl Ethers; D008737:Methyl Chloride