title: Mapping of functional neural pathways by autoradiographic survey of local metabolic rate with (14C)deoxyglucose.
abstract: An enzymatic preparation from human brain converts tryptamine to tryptoline (9H-1,2,3,4-tetrahydropyrido(3,4-b)indole) in the presence of 5-methyltetrahydrofolic acid. Similarly, N-methyltryptamine and 5-hydroxytryptamine yield 1-methyltryptoline and 5-hydroxytryptoline, respectively. Neither in vitro nor in vivo formation of these compounds by human tissues has been described.
mesh_terms: D000818:Animals; D001345:Autoradiography; D001921:Brain / Q000033:anatomy & histology / Q000378:metabolism* / Q000502:physiology; D001931:Brain Mapping / Q000379:methods*; D002250:Carbon Radioisotopes; D003837:Deoxy Sugars / Q000378:metabolism*; D003847:Deoxyglucose / Q000378:metabolism*; D004558:Electric Stimulation; D005071:Evoked Potentials; D008253:Macaca mulatta; D008297:Male; D009434:Neural Pathways / Q000033:anatomy & histology / Q000502:physiology; D051381:Rats; D013116:Spinal Cord / Q000033:anatomy & histology / Q000502:physiology; D014795:Visual Pathways / Q000033:anatomy & histology / Q000502:physiology
chemical_list: D002250:Carbon Radioisotopes; D003837:Deoxy Sugars; D003847:Deoxyglucose