Activation by pyridoxal 5-phosphate of aspartate transaminase in serum of patients with heart and liver disease.
When aspartate transaminase activity in serum is increased, pyridoxal 5-phosphate addition produces more pronounced activation of post-myocardial infarct sera than of sera from patients with chronic liver disease. Possible explanations for this are considered. Routine pre-incubation of sera with pyridoxal phosphate prior to aspartate transaminase determination is recommended.
D001219:Aspartate Aminotransferases / Q000097:blood / Q000378:metabolism*; D002908:Chronic Disease; D004796:Clinical Enzyme Tests; D004789:Enzyme Activation; D006801:Humans; D008099:Liver / Q000201:enzymology; D008107:Liver Diseases / Q000175:diagnosis / Q000201:enzymology*; D009203:Myocardial Infarction / Q000175:diagnosis / Q000201:enzymology; D009206:Myocardium / Q000201:enzymology; D011732:Pyridoxal Phosphate / Q000494:pharmacology*
D011732:Pyridoxal Phosphate; D001219:Aspartate Aminotransferases