The influence of thyroid stimulation on the incidence of 3-methylcholanthrene-induced tumors.
The incidence of tumors induced by a single s.c. injection of 2 mg of 3-methylcholanthrene was observed in euthyroid and thyroidectomized rats and in rats fed thyroid powder. Thyroid feeding increased the metabolic rate by a factor of 1.6 and reduced the incidence of tumors at the site of injection from 92% in euthyroid rats to 36% in hyperthyroid rats.
D000818:Animals; D002273:Carcinogens; D004326:Drinking; D004435:Eating; D005260:Female; D006980:Hyperthyroidism; D008748:Methylcholanthrene; D009374:Neoplasms, Experimental / Q000139:chemically induced*; D010101:Oxygen Consumption; D051381:Rats; D013961:Thyroid Gland; D013965:Thyroidectomy; D013997:Time Factors
D002273:Carcinogens; D008748:Methylcholanthrene