title: Different effects of bacterial lipopolysaccharide on neonatal immunological tolerance to HSA in rabbits and chickens.
abstract: Addition of bacterial lipopolysaccharide to HSA during repeated immunization of rabbits neonatally rendered tolerant to HSA led to anti-HSA antibody formation in 4 out of 5 animals. In all 6 tolerant animals immunized with HSA alone tolerance persisted after cessation of the immunization series, as shown by non-immune elimination of 125I-HSA. On the other hand, immunization with HSA together with different doses of LPS did not increase anti-HSA antibody levels in tolerant and control chickens.
mesh_terms: D000818:Animals; D000831:Animals, Newborn; D000917:Antibody Formation / Q000187:drug effects; D000918:Antibody Specificity; D002645:Chickens / Q000276:immunology*; D004926:Escherichia coli; D007108:Immune Tolerance / Q000187:drug effects*; D007114:Immunization; D008070:Lipopolysaccharides / Q000494:pharmacology*; D011817:Rabbits / Q000276:immunology*; D012709:Serum Albumin / Q000494:pharmacology
chemical_list: D008070:Lipopolysaccharides; D012709:Serum Albumin