title: The charge-transfer constant. A new substituent constant for structure-activity relationships.
abstract: A new, versatile constant accounting for the pi-complex formation ability of aromatic systems is proposed. The constant is derived from charge-transfer complex data of aromatic species (charge-transfer constant, CT). The applicability of CT in structure-reactivity relations is demonstrated. It is shown that the affinity of various inhibitors (32) and acetylcholinesterase is a function of CT and pi (Hansch hydrophobicity constant).
mesh_terms: D001555:Benzene Derivatives; D002219:Carbamates; D055598:Chemical Phenomena; D002621:Chemistry; D002800:Cholinesterase Inhibitors; D007700:Kinetics; D008433:Mathematics; D008956:Models, Chemical; D013056:Spectrophotometry, Ultraviolet; D013329:Structure-Activity Relationship
chemical_list: D001555:Benzene Derivatives; D002219:Carbamates; D002800:Cholinesterase Inhibitors