title: Coxsackievirus B5 infection and aseptic meningitis in neonates and children.
abstract: In metropolitan Washington, DC, an outbreak of aseptic meningitis in children was recognized in the summer and fall of 1972. Age-specific attack rates were highest in children less than 1 year of age. The incidence of cases showed two peaks: one in July and another in October. Coxsackievirus B5 was associated with cases occurring in July, August, and September, but was not implicated in the October cases. Seventy-six percent of the confirmed coxsackievirus B5 infections in aseptic meningitis patients occurred in infants less than 2 months old. Specific meningeal symptoms were less frequently observed in these young infants, although viral isolations were more common (13 of 15) compared to patients over 2 months of age (four of 19). Analysis of reported coxsackievirus B5 infections in Washington, DC, and the United States as a whole suggests a five- or six-year periodicity.
mesh_terms: D000293:Adolescent; D000367:Age Factors; D002556:Cerebrospinal Fluid Proteins / Q000032:analysis; D002648:Child; D002675:Child, Preschool; D003384:Coxsackievirus Infections / Q000150:complications / Q000453:epidemiology*; D004219:District of Columbia; D004770:Enterovirus / Q000276:immunology / Q000302:isolation & purification; D005260:Female; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007770:L-Lactate Dehydrogenase / Q000134:cerebrospinal fluid; D007958:Leukocyte Count; D008297:Male; D008396:Maryland; D008581:Meningitis / Q000150:complications / Q000453:epidemiology*; D010507:Periodicity; D012737:Sex Factors; D014768:Virginia
chemical_list: D002556:Cerebrospinal Fluid Proteins; D007770:L-Lactate Dehydrogenase