title: Pressure-flow relationships in the peripheral circulation of the dog with practolol.
abstract: 1. The influence of practolol (a proposed beta1-adrenoreceptor antagonist) upon the pressure-flow relationships in the peripheral circulation was studied in eight anaesthetized dogs during right heart by-pass procedures. 2. Practool (1 mg/kg) produced a significant increase in the resistance to venous return which resulted in a significant fall in venous return. 3. There was no significant change in arterial resistance. 4. This study suggests that practolol should not be classified as an exclusive cardioselective beta-adrenoreceptor antagonist.
mesh_terms: D000818:Animals; D001013:Aorta, Thoracic; D001794:Blood Pressure / Q000187:drug effects*; D002302:Cardiac Output / Q000187:drug effects; D003326:Coronary Circulation / Q000187:drug effects*; D004285:Dogs; D011217:Practolol / Q000494:pharmacology*; D014655:Vascular Resistance / Q000187:drug effects; D014680:Veins; D014690:Venous Pressure / Q000187:drug effects
chemical_list: D011217:Practolol