title: Changes in regional blood flow and cardiodynamics associated with electrically and chemically induced epilepsy in cat.
abstract: Changes in cardiodynamics and regional blood flow were examined in chronically prepared paralyzed cats during seizures induced electrically by transcerebral or direct cortical stimulation or by administration of flurothyl ether (Indoklon) or pentylenetetrazol (Metrazol). Transcerebral and chemical stimuli produced the greatest vascular responses. During seizures there was an abrupt elevation of arterial pressure unassociated with consistent changes in heart rate. Vascular resistance was increased in femoral, renal and mesenteric arteries with variable reductions in blood flow. Resistance was decreased and flow passively increased in the common carotid artery reflecting the loss of cerebral autoregulation. Cardiac output was unchanged. With seizures associated with large elevations of arterial pressure, the central venous and left ventricular end-diastolic pressures were markedly increased indicating incipient congestive failure. The pressor response was blocked by alpha-adrenergic blockade with phentolamine. Increased regional vascular resistance was abolished by regional sympathectomy. While either adrenalectomy or treatment with 6-hydroxydopamine alone failed to abolish the pressor response, combined, they did. Such treatment unmasked an atropine-sensitive bradycardia. The pressor response with seizures is a consequence of increased vascular resistance in viscera and muscles due to widespread activation of sympathetic neurons and release of adrenomedullary catecholamines. Co-activation of cardiovagal and cardiosympathetic neurons may underlie some associated arrhythmias. Cardiovascular events may severe, by redistribution of the cardiac output, to assure increased availability of oxygen and nutrients to brain to meet the metabolic demands of convulsions.
mesh_terms: D000315:Adrenalectomy; D000818:Animals; D001285:Atropine / Q000494:pharmacology; D001794:Blood Pressure; D002302:Cardiac Output; D002415:Cats; D004558:Electric Stimulation; D004569:Electroencephalography; D004827:Epilepsy / Q000139:chemically induced* / Q000503:physiopathology; D005481:Flurothyl; D006339:Heart Rate; D006439:Hemodynamics; D006892:Hydroxydopamines / Q000494:pharmacology; D009493:Neurosurgery; D010291:Paresis / Q000139:chemically induced; D010433:Pentylenetetrazole; D010646:Phentolamine / Q000494:pharmacology; D012039:Regional Blood Flow; D013562:Sympathectomy; D014655:Vascular Resistance
chemical_list: D006892:Hydroxydopamines; D001285:Atropine; D005481:Flurothyl; D010433:Pentylenetetrazole; D010646:Phentolamine