The effect of caffeine on survival of UV-irradiated diploid yeast strains of different sensitivities.
The action of caffeine post-treatment after UV exposure in three strains of diploid yeast has been studied. The addition of the drug to the plating medium reduced survival in all cases. Higher colony-forming abilities were found in all strains when the UV dose had been split into two fractions with an interval of about 6 h. Caffeine added to the incubation medium between dose fractions did not interfere with this process in the wild type but suppressed split-dose sparing completely in two sensitive strains.
D002110:Caffeine / Q000494:pharmacology*; D002470:Cell Survival / Q000187:drug effects / Q000528:radiation effects; D004260:DNA Repair / Q000187:drug effects; D004171:Diploidy; D004307:Dose-Response Relationship, Radiation; D009154:Mutation; D011831:Radiation Genetics; D011838:Radiation-Sensitizing Agents; D012441:Saccharomyces cerevisiae / Q000187:drug effects* / Q000528:radiation effects; D014466:Ultraviolet Rays
D011838:Radiation-Sensitizing Agents; D002110:Caffeine