title: Catechol estrogen formation in the central nervous system of the rat.
abstract: Conversion of estradiol and estrone to catechol estrogens by rat hypothalamic tissue but not by the cerebral cortex was demonstrated from the incubation of these tissues with estradiol-2-3H and estrone-2-3H and monitoring the incorporation of tritium into water. Direct evidence for this transformation was obtained by isolating the labelled phenazine derivative of 2-hydroxyestrone after hypothalamic incubation with estrone-4-14C.
mesh_terms: D000818:Animals; D001921:Brain / Q000378:metabolism*; D002396:Catechols / Q000378:metabolism*; D002540:Cerebral Cortex / Q000378:metabolism; D004958:Estradiol / Q000378:metabolism; D004967:Estrogens / Q000378:metabolism*; D004970:Estrone / Q000378:metabolism; D005260:Female; D007031:Hypothalamus / Q000378:metabolism; D066298:In Vitro Techniques; D051381:Rats; D014867:Water / Q000096:biosynthesis
chemical_list: D002396:Catechols; D004967:Estrogens; D014867:Water; D004970:Estrone; D004958:Estradiol