title: 99mTc-pertechnetate thyroid scintigraphy in patients predisposed to thyroid neoplasms by prior radiotherapy to the head and neck.
abstract: Histories, physical examinations and 99mTc-pertechnetate imaging were used to evaluate 1,452 persons who had had x-ray therapy to the neck region for benign conditions 18 to 35 years previously. Thyroid abnormalities were found in 301 patients (21%) and thyroid malignancy was found in 29% of 193 patients with abnormal studies who were explored surgically. Thyroid imaging detected 96% of these abnormalities, 40% of which would not have been unequivocally established by physical examination alone. Nuclear imaging could not distinguish benign from malignant lesions.
mesh_terms: D000230:Adenocarcinoma / Q000175:diagnosis / Q000209:etiology*; D000328:Adult; D002291:Carcinoma, Papillary / Q000175:diagnosis / Q000209:etiology*; D005260:Female; D006801:Humans; D008297:Male; D009381:Neoplasms, Radiation-Induced / Q000175:diagnosis / Q000453:epidemiology*; D011877:Radionuclide Imaging; D011878:Radiotherapy / Q000009:adverse effects*; D013667:Technetium; D013964:Thyroid Neoplasms / Q000175:diagnosis / Q000209:etiology*; D014481:United States; D014965:X-Rays
chemical_list: D013667:Technetium