Marginal ulcer in achlorhydric patients.
Recurrent gastrojejunal ulceration is reported in three patients with histamine-fast achlorhydria. In none of these patients was extruding suture material responsible for the ulceration. However, all three patients had a history of alcohol abuse, and one abused aspirin as well. These cases demonstrate that achlorhydria does not protect against anastomotic ulceration. It is suggested that surgical manipulation produces an increased susceptibility to mucosal damage, and that it is erroneous to consider all anastomotic ulceration as a continuation or recurrence of acid peptic disease.
D000126:Achlorhydria / Q000150:complications* / Q000175:diagnosis; D000368:Aged; D000437:Alcoholism / Q000150:complications; D001241:Aspirin / Q000009:adverse effects; D005743:Gastrectomy / Q000009:adverse effects; D005745:Gastric Acidity Determination; D005750:Gastric Juice / Q000378:metabolism; D005753:Gastric Mucosa / Q000378:metabolism; D005773:Gastroscopy; D006632:Histamine; D006801:Humans; D008297:Male; D008875:Middle Aged; D010437:Peptic Ulcer / Q000139:chemically induced / Q000150:complications* / Q000209:etiology; D012189:Retrospective Studies
D006632:Histamine; D001241:Aspirin