title: Use of prostaglandin E2 vaginal suppositories in intrauterine fetal death and missed abortion.
abstract: Twenty patients with either missed abortions or intrauterine fetal death were induced with prostaglandin (PGE2) vaginal suppositories. The uterus is surprisingly responsive to PGE2 in cases of intrauterine death, yielding a short treatment-delivery interval. Blood coagulopathies which can develop after intrauterine death can be avoided through early diagnosis and treatment. Eighteen patients completely delivered and there were no serious complications. The remaining 2 patients required curettage. Side effects were mild in nature, consisting of occasional gastrointestinal symptoms. This method is now a standard procedure in cases of intrauterine fetal death and missed abortion at Yale-New Haven Medical Center.
mesh_terms: D000028:Abortion, Induced; D000030:Abortion, Missed / Q000601:surgery*; D000293:Adolescent; D000328:Adult; D001780:Blood Coagulation Tests; D003475:Curettage; D005260:Female; D005313:Fetal Death / Q000601:surgery*; D006801:Humans; D008875:Middle Aged; D011247:Pregnancy; D011453:Prostaglandins / Q000008:administration & dosage* / Q000009:adverse effects / Q000494:pharmacology; D013488:Suppositories; D014599:Uterus / Q000187:drug effects; D014621:Vagina
chemical_list: D011453:Prostaglandins; D013488:Suppositories