Iridoplegia and aqueous flare due to acute herpetic keratouveitis.
Functional disturbances due to herpetic keratouveitis in rabbits were investigated. Measurements of pupillary reactivity and exudative processes in the anterior chamber with marked elevations of aquenous proteins and enzymes (LDH and GOT) were used to determine virus-induced pharmacodynamic changes by application of several autonomic and antiviral agents. Characteristic features included the earlier occurrence of hyperreactivity to Mecholyl and epinephrine and the later development of iridoplegia unreponsive to cocaine or atropine. An increase of aqueous proteins causing aqueous flare was suppressed by application of PPP. These patterns were compared with those of acute ocular responses to various types of injuries caused by fromalin, bacterial endotoxins and immunological sensitization with bovine albumin. This experimental herpetic keratouveitis in rabbits appeared similar to Wellings' ocular syndrome,which is suspected to be of herpetic etiology.
D000208:Acute Disease; D000818:Animals; D001082:Aqueous Humor; D003609:Dactinomycin / Q000494:pharmacology; D005128:Eye Diseases / Q000209:etiology; D005136:Eye Proteins / Q000378:metabolism; D006918:Hydroxyurea / Q000494:pharmacology; D007498:Iris; D007635:Keratitis, Dendritic / Q000150:complications*; D010243:Paralysis / Q000209:etiology; D011817:Rabbits; D013997:Time Factors; D014605:Uveitis / Q000209:etiology*
D005136:Eye Proteins; D003609:Dactinomycin; D006918:Hydroxyurea