title: Clinical applications of the continuous flow blood separator machine.
abstract: The NCl/IBM or Aminco Continuous Flow Blood Separator Machine is a safe apparatus for the selective removal or exchange of either packed red blood cells, leucocyte-rich or platelet-rich layers or plasma. Abnormal fractions from any of these layers may be collected and discarded. Normal constituents may be collected for therapeutic uses. The wide scope of its applications includes important uses in clinical immunology: temporary provision of good leucocytes or platelets; harvesting of immune leucocytes (preparation of transfer factor at up to 10 units per harvest); removal of cryo- or macro-globulins, immune complexes or blocking factors; replacement therapy for antibody or complement deficiencies. Examples are given of such uses together with some of the medical problems so far encountered.
mesh_terms: D000328:Adult; D000361:Agammaglobulinemia / Q000628:therapy; D000368:Aged; D000744:Anemia, Hemolytic, Autoimmune / Q000628:therapy; D000906:Antibodies; D000936:Antigen-Antibody Complex; D001145:Arrhythmias, Cardiac / Q000209:etiology; D001323:Autoantibodies; D001769:Blood; D001792:Blood Platelets; D002469:Cell Separation / Q000295:instrumentation; D002498:Centrifugation / Q000295:instrumentation; D004912:Erythrocytes; D005078:Exchange Transfusion, Whole Blood; D005260:Female; D006098:Granulocytes; D006333:Heart Failure / Q000209:etiology; D006493:Heparin / Q000627:therapeutic use; D006801:Humans; D006996:Hypocalcemia / Q000209:etiology; D007022:Hypotension / Q000209:etiology; D007938:Leukemia / Q000628:therapy; D007962:Leukocytes; D008107:Liver Diseases / Q000628:therapy; D008297:Male; D008875:Middle Aged; D009369:Neoplasms / Q000628:therapy; D009447:Neuroblastoma / Q000628:therapy; D010265:Paraproteinemias / Q000628:therapy; D010956:Plasmapheresis; D013575:Syncope / Q000209:etiology; D014165:Transfer Factor
chemical_list: D000906:Antibodies; D000936:Antigen-Antibody Complex; D001323:Autoantibodies; D014165:Transfer Factor; D006493:Heparin