The efficacy of intramuscular 15 methyl prostaglandin E2 in second-trimester abortion. Coagulation and hormonal aspects.
Termination of pregnancy in the second trimester is sometimes associated with serious complications. This led to clinical investigation seeking methods superior to the traditional technique utilizing hypertonic saline. Intra-amniotic administration of naturally occurring prostaglandin F2-alpha has been developed and appears to be advantageous--especially in the area of coagulation stability. This study describes a technique for intramuscular administration of a prostaglandin analogue--15 methyl prostaglandin E2. This analogue is much more potent than the natural compound. Administration to 32 patients resulted in abortion in 28. The coagulation milieu remained completely intact and all other parameters were similar to previous published data for prostaglandin administration. There were no infections in this group of patients.
D000019:Abortifacient Agents / Q000008:administration & dosage*; D000028:Abortion, Induced / Q000009:adverse effects / Q000379:methods*; D000328:Adult; D000653:Amniotic Fluid; D001777:Blood Coagulation / Q000187:drug effects*; D001780:Blood Coagulation Tests; D001792:Blood Platelets / Q000187:drug effects; D055598:Chemical Phenomena; D002621:Chemistry; D004341:Drug Evaluation; D005165:Factor V / Q000032:analysis; D005170:Factor X / Q000032:analysis; D005260:Female; D005340:Fibrinogen / Q000032:analysis; D005865:Gestational Age; D006801:Humans; D006854:Hydrocortisone / Q000097:blood*; D006982:Hypertonic Solutions / Q000008:administration & dosage; D007273:Injections, Intramuscular; D007962:Leukocytes / Q000187:drug effects; D009504:Neutrophils / Q000187:drug effects; D011247:Pregnancy; D011262:Pregnancy Trimester, Second; D011374:Progesterone / Q000097:blood*; D011453:Prostaglandins / Q000008:administration & dosage* / Q000009:adverse effects; D011517:Prothrombin Time; D012965:Sodium Chloride / Q000008:administration & dosage; D013925:Thromboplastin; D013997:Time Factors; D014599:Uterus / Q000187:drug effects
D000019:Abortifacient Agents; D006982:Hypertonic Solutions; D011453:Prostaglandins; D012965:Sodium Chloride; D011374:Progesterone; D005165:Factor V; D005170:Factor X; D005340:Fibrinogen; D013925:Thromboplastin; D006854:Hydrocortisone