Cellular basis of tolerance in neonatally induced mouse chimeras.
In mice, thymectomized as young adults, neonatally induced tolerance persists in the putative absence of cell chimerism. The finding provides evidence that a selective deficiency of specific clones of lymphocytes exists in transplantation tolerance when induced under the conditions of these experiments.
D000818:Animals; D000831:Animals, Newborn / Q000276:immunology*; D002678:Chimera; D005260:Female; D007108:Immune Tolerance; D007111:Immunity, Cellular; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D016038:Skin Transplantation; D013601:T-Lymphocytes / Q000276:immunology; D013934:Thymectomy; D013950:Thymus Gland / Q000276:immunology; D014184:Transplantation, Homologous