Tumor suppression by pyran copolymer: correlation with production of cytotoxic macrophages.
Intraperitoneal administration of pyran copolymer (pyran-2-succinic anhydride-4,5-dicarboxytetrahydro-6-methylanhydride polymer) protected C3H/HeN male mice against tumor development after intradermal challenge with cells of the transplantable, methylcholanthrene-induced, syngeneic fibrosarcoma 1038. Peritoneal cells from pyran-treated but not from normal animals suppressed tumor development in local passive-transfer experiments. Adherent peritoneal cells from pyran-treated mice were cytotoxic in vitro to several syngeneic murine tumor cell lines including 1038.
D000818:Animals; D001202:Ascitic Fluid / Q000166:cytology; D002460:Cell Line; D003601:Cytotoxicity Tests, Immunologic; D005354:Fibrosarcoma / Q000139:chemically induced / Q000276:immunology / Q000517:prevention & control*; D007116:Immunization, Passive; D008264:Macrophages / Q000276:immunology*; D008297:Male; D008748:Methylcholanthrene; D051379:Mice; D008809:Mice, Inbred C3H; D009368:Neoplasm Transplantation; D011108:Polymers / Q000627:therapeutic use*; D011713:Pyran Copolymer / Q000627:therapeutic use*; D012513:Sarcoma, Experimental / Q000139:chemically induced / Q000276:immunology / Q000517:prevention & control; D014184:Transplantation, Homologous
D011108:Polymers; D011713:Pyran Copolymer; D008748:Methylcholanthrene