A simple model of the hemodynamic effects of a proximal coronary artery narrowing.
A simple mathematical model of the hemodynamic effects of a discrete proximal coronary artery obstruction is presented. The model demonstrates that resting myocardial flow demands fail to be met when the vessel diameter is decreased by 75% or greater. More strikingly, it shows that the maximum flow obtainable for increased myocardial oxygen demand begins to fall significantly with a lesion causing a 40 to 50% obstruction. The implications of these findings in relation to stress-induced angina are discussed.
D003326:Coronary Circulation; D003327:Coronary Disease / Q000503:physiopathology*; D006801:Humans; D008954:Models, Biological; D014655:Vascular Resistance