Cycloalkanones. 6. Separation of hypocholesterolemic and antifertility activities in derivatives of 2,8-dibenzylcyclooctanone.
Fluoro and hydroxy derivatives of 2,8-dibenzylcyclooctanone were prepared. Separation of antifertility activity from hypolipidemic and uterotropic effects was achieved with 2,8-bis(4-acetoxybenzyl)cyclooctanone. Some enhancement of the hypolipidemic effect in relation to the uterotropic and antifertility activities was seen in 2,8-bis(4-fluorobenzyl)cyclooctanone. Synthetic methods for the hydroxy compounds are presented.
D000818:Animals; D000924:Anticholesteremic Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D001593:Benzyl Compounds / Q000138:chemical synthesis / Q000494:pharmacology; D001835:Body Weight / Q000187:drug effects; D002784:Cholesterol / Q000097:blood; D003516:Cycloparaffins / Q000138:chemical synthesis* / Q000494:pharmacology; D004967:Estrogens / Q000494:pharmacology; D005260:Female; D005298:Fertility / Q000187:drug effects*; D007659:Ketones / Q000138:chemical synthesis / Q000494:pharmacology; D008099:Liver / Q000187:drug effects; D008297:Male; D051379:Mice; D009929:Organ Size; D051381:Rats; D012669:Seminal Vesicles / Q000187:drug effects; D013737:Testis / Q000187:drug effects; D014280:Triglycerides / Q000097:blood; D014599:Uterus / Q000187:drug effects; D014649:Vas Deferens / Q000187:drug effects
D000924:Anticholesteremic Agents; D001593:Benzyl Compounds; D003516:Cycloparaffins; D004967:Estrogens; D007659:Ketones; D014280:Triglycerides; D002784:Cholesterol