Age trends in human chiasma frequencies and recombination fractions. II. Method for analyzing recombination fractions and applications to the ABO:nail-patella linkage.
A new method is presented for studying the relationship between human recombination fractions and parental age at the time of conception. Assuming the sex specific recombination fraction to be a linear function of age, a feasible computer algorithm is described whereby the likelihood of multigenerational families can be calculated. Using this method and the likelihood ratio test, it is found that for the ABO:nail-patella linkage age (P= .17)is more significant than sex (p= .23) in its effect on the recombination fraction. The age effect, if it is real, appears to be limited to males: the paternal recombination fraction decreases by .0062(+/- .0036) per year.
D000017:ABO Blood-Group System; D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000483:Alleles; D003201:Computers; D005260:Female; D008040:Genetic Linkage; D005821:Genetic Techniques; D006801:Humans; D008297:Male; D008875:Middle Aged; D009261:Nail-Patella Syndrome / Q000235:genetics*; D010375:Pedigree; D011995:Recombination, Genetic; D012737:Sex Factors
D000017:ABO Blood-Group System