Hereditary hemorrhagic telangiectasia (Osler-Weber-Rendu disease). An electron microscopic study of the vascular lesions before and after therapy with hormones.
Eight patients with hereditary hemorrhagic telangiectasia and severe epistaxis were treated with norethynodrel with mestranol (Enovid). Biopsy specimens of typical lesions from two patients were taken for electron microscopy before and after several months of therapy. Characteristic endothelial cell damage and nectosis were noted in the dilated venules of patients before treatment but not after. Unlined channels of blood were found in connective tissue before treatment but not after. These are thought to arise from leaks in the affected venules, and it is suggested that later indothelial ingrowth gives rise to the propagation of lesions that are known to develop with age. Reduplicated basal laminae and regenerating endothelial cells were found both before and after treatment.
D001706:Biopsy; D003238:Connective Tissue / Q000187:drug effects / Q000473:pathology; D004338:Drug Combinations; D004727:Endothelium / Q000187:drug effects / Q000473:pathology; D004844:Epistaxis / Q000150:complications; D004903:Erythrocyte Aggregation / Q000209:etiology; D006801:Humans; D008656:Mestranol / Q000494:pharmacology / Q000627:therapeutic use*; D008854:Microscopy, Electron; D009336:Necrosis; D009641:Norethynodrel / Q000494:pharmacology / Q000627:therapeutic use*; D013683:Telangiectasia, Hereditary Hemorrhagic / Q000150:complications / Q000188:drug therapy / Q000473:pathology*; D014059:Tongue / Q000098:blood supply / Q000187:drug effects / Q000473:pathology; D014420:Turbinates / Q000098:blood supply / Q000187:drug effects / Q000473:pathology; D014680:Veins / Q000473:pathology*
D004338:Drug Combinations; D009641:Norethynodrel; D008656:Mestranol