title: Atypical germ cells in the adjacent "normal" tissue of testicular tumours.
abstract: Recently a possible intratubular carcinoma-in-situ of the human testis was described. The same histological picture has been found in the residual testicular tissue in 17 out of 22 men with either seminoma, embryonal carcinoma or terato-carcinoma. The hypothesis is put forward that the described cells may represent malignant germ cells from which testicular germ cell tumours of different types may originate.
mesh_terms: D000293:Adolescent; D000328:Adult; D002455:Cell Division; D002467:Cell Nucleus; D002843:Chromatin; D004407:Dysgerminoma / Q000473:pathology*; D005854:Germ Cells / Q000473:pathology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D012708:Sertoli Cells; D013724:Teratoma / Q000473:pathology*; D013736:Testicular Neoplasms / Q000473:pathology*
chemical_list: D002843:Chromatin