title: Safety of administration of procaine hydrochloride-hematoporphyrin (KH3) to beagle dogs.
abstract: Data were collected as to food consumption, body weight, coat condition, blood cells and chemical constituents, as well as physical and chemical characteristics of urine on 31 adult Beagle dogs (male and female) during a control period and later at monthly intervals during course of the study. After the control period, the dogs were divided into four groups and were given orally for 90 days either placebo, 0.5 gm. (one capsule), 1.5 gm., or 3 gm. of KH3 per day. At the end of the study, animals were necropsied and organs weighed. The coat appeared to be glossy and have luxurious growth. The other parameters studied showed no significant variations from control or normal ranges. Tissues revealed no gross or microscopic abnormalities which could be attributed to treatment. On the basis of this study, KH3 does not appear to have any deleterious effect on dogs at dose levels which are substantially higher than those recommended for animal or human usage.
mesh_terms: D000818:Animals; D001344:Autopsy; D001773:Blood Cells / Q000187:drug effects; D001774:Blood Chemical Analysis; D001835:Body Weight / Q000187:drug effects; D004285:Dogs; D004338:Drug Combinations; D005260:Female; D006197:Hair / Q000187:drug effects; D006415:Hematoporphyrins / Q000633:toxicity*; D008297:Male; D009929:Organ Size; D010919:Placebos; D011343:Procaine / Q000633:toxicity*; D014556:Urine / Q000032:analysis
chemical_list: D004338:Drug Combinations; D006415:Hematoporphyrins; D010919:Placebos; D011343:Procaine