The level of GABA in the brain and locomotor behavior.
GABA content was measured in the brains of animals injected with AOAA, DPA or Saline. Significant increases in GABA were found in the motor cortex and cerebellum after treatment with both drugs as compared to saline injected controls. Increased GABA levels were associated with interference with the smooth execution of locomotor acts, especially where balancing and coordination of the hind limbs were necessary.
D000613:Aminobutyrates / Q000378:metabolism*; D000625:Aminooxyacetic Acid / Q000494:pharmacology; D000818:Animals; D001921:Brain / Q000378:metabolism*; D001923:Brain Chemistry / Q000187:drug effects; D002531:Cerebellum / Q000378:metabolism; D003864:Depression, Chemical; D008297:Male; D009043:Motor Activity / Q000187:drug effects / Q000502:physiology*; D009044:Motor Cortex / Q000378:metabolism; D009048:Motor Skills / Q000187:drug effects; D051381:Rats; D013997:Time Factors; D014635:Valproic Acid / Q000494:pharmacology; D005680:gamma-Aminobutyric Acid / Q000378:metabolism*
D000613:Aminobutyrates; D000625:Aminooxyacetic Acid; D005680:gamma-Aminobutyric Acid; D014635:Valproic Acid