Enzyme potentiated hyposensitization: IV. effect of protamine on the immunological behavior of beta glucuronidase in mice and patients with hay fever.
The ability of beta glucuronidase and a small dose of antigen to modify the anaphylactic reaction of previously sensitized mice has been further investigated. Protamine has an important effect on the immunological behavior of the enzyme. A trial on hay fever patients shows that the results in mice are relevant and that the method can produce significant clinical hyposensitization.
D000818:Animals; D003510:Cyclohexanes; D003888:Desensitization, Immunologic; D004305:Dose-Response Relationship, Drug; D005966:Glucuronidase / Q000627:therapeutic use*; D006801:Humans; D007117:Immunization, Secondary; D051379:Mice; D011058:Pollen; D011479:Protamines / Q000494:pharmacology*; D006255:Rhinitis, Allergic, Seasonal / Q000628:therapy*
D003510:Cyclohexanes; D011479:Protamines; D005966:Glucuronidase