title: Genetics of patent ductus arteriosus.
abstract: A genetic study of 119 correlative cases of patent ductus arteriosus has been performed. The isolated cases showed female predominance, but there was a three times higher risk for the sibs of male cases, suggesting a multifactorial causative mechanism. Dermatoglyphs presented an excess of arches in male, and a tendency to distal axial triradius in female. There were 15 cases belonging to polymalformative syndromes, such as mongolism, Turner, Noonan, Holt-Oram, Lewis and rubella embryopathy.
mesh_terms: D000328:Adult; D000818:Animals; D002648:Child; D003878:Dermatoglyphics; D004285:Dogs; D004374:Ductus Arteriosus, Patent / Q000235:genetics*; D005260:Female; D006801:Humans; D007621:Karyotyping; D008297:Male; D008875:Middle Aged; D012737:Sex Factors