Activity of 6-methyl-8-substituted ergolines against the 7,12-dimethylbenz(a)anthracene-induced mammary carcinoma.
The ability of a series of 8-beta-carboxamido ergolines, 8-formamido ergolines, and 8-methyl ergolines to cause regressions of established dimethylbenz[a]anthracene-induced mammary carcinomas was compared to some ergot alkaloids. Although most of the ergoline derivatives depressed serum prolactin concentrations in rats, only a few had pronounced effects against the dimethylbenz[a]anthracene-induced mammary carcinoma in rats. Some derivatives from each of the three groups of substituted ergolines gave comparable activities against the dimethylbenz[a]anthracene-induced mammary carcinoma.
D000818:Animals; D001551:Benz(a)Anthracenes; D002273:Carcinogens; D055598:Chemical Phenomena; D002621:Chemistry; D004873:Ergolines / Q000627:therapeutic use*; D004874:Ergonovine / Q000627:therapeutic use; D004876:Ergot Alkaloids / Q000627:therapeutic use; D004878:Ergotamine / Q000627:therapeutic use; D005260:Female; D005559:Formamides; D008325:Mammary Neoplasms, Experimental / Q000097:blood / Q000139:chemically induced / Q000188:drug therapy*; D011388:Prolactin / Q000097:blood; D051381:Rats
D001551:Benz(a)Anthracenes; D002273:Carcinogens; D004873:Ergolines; D004876:Ergot Alkaloids; D005559:Formamides; D011388:Prolactin; D004878:Ergotamine; D004874:Ergonovine