In vitro interaction of prostaglandin F2alpha and oxytocin in placental vessels.
The interaction of prostaglandin F2alpha and synthetic oxytocin on placental vessels was studied in vitro. Resistance was measured near the placental margin after spontaneous term delivery. In seven experiments reactions to norepinephrine and oxytocin were PGF2alpha. PGF2alpha produced significantly increased vasoconstriction after a single administration of oxytocin. In eight experiments the perfusion medium contained oxytocin. There was no change after a single dose of PGF2alpha. The reaction after norepinephrine remained the same in both groups of experiments. There is thus an "enhancement effect" of PGF2alpha upon the reaction of placental vessels to oxytocin in vitro.
D001808:Blood Vessels / Q000187:drug effects; D004347:Drug Interactions; D005260:Female; D006801:Humans; D066298:In Vitro Techniques; D009638:Norepinephrine / Q000494:pharmacology; D010121:Oxytocin / Q000494:pharmacology*; D010920:Placenta / Q000098:blood supply*; D011247:Pregnancy; D011453:Prostaglandins / Q000494:pharmacology*; D014655:Vascular Resistance / Q000187:drug effects
D011453:Prostaglandins; D010121:Oxytocin; D009638:Norepinephrine