Mutagenic studies of aziridine derivatives derived from various diamines.
Various aziridine derivatives derived from diamines were studied in several biological systems to evaluate their effects on reproduction and as potential mutagens. Considerable variations in the biological activities of these compounds were seen among animal species and among the varied chemical structures. In general, mutagenic responses paralleled the antifertility effects in mice and houseflies and the anticancer effects in mice. The lack of an antifertility effect by N,N'-bis(aziridinylacetyl)-1,8-octamethylenediamine in the rat was quite unexpected in view of its chemosterilant activity in houseflies and mice.
D000818:Animals; D001388:Aziridines / Q000494:pharmacology* / Q000627:therapeutic use; D001389:Azirines / Q000494:pharmacology*; D002286:Carcinoma, Ehrlich Tumor / Q000188:drug therapy; D002629:Chemosterilants / Q000494:pharmacology; D002869:Chromosome Aberrations; D003959:Diamines / Q000494:pharmacology*; D005260:Female; D005298:Fertility / Q000187:drug effects; D005799:Genes, Dominant; D005804:Genes, Lethal; D006793:Houseflies / Q000187:drug effects; D008297:Male; D051379:Mice; D008938:Mitosis; D009153:Mutagens / Q000494:pharmacology*; D009154:Mutation; D011784:Quail; D051381:Rats; D013329:Structure-Activity Relationship
D001388:Aziridines; D001389:Azirines; D002629:Chemosterilants; D003959:Diamines; D009153:Mutagens