title: Effect of the rhythm of cyclophosphamide administration on its antitumor action and the immune response of mice with methylcholanthrene sarcoma.
abstract: The therapeutic effect of cyclophosphamide (CP) in relation to the dose and rhythum of its administration was studied in C57BL/6 mice with a methycholanthrene-induced sarcoma. The optimal scheme giving a complete cure of the experimental animals was 5 injections, each of  199 mg/kg CP at intervals of 10 days. The effect of the total dose of CP on humoral antitumor immunity was demonstrated: after injection  of 100 mg/kg CP the animals' serum lost its ability to stimulate tumor growth and acquired cytotoxic properties. The serum of animals receiving the total doses of CP above 400 mg/kg lost its effect on tumor growth. The doses of CP used did not affect cellular antitumor immunity (the cytotoxicity of the lymphocytes and resistance of the tumor to retransplantation.).
mesh_terms: D000818:Animals; D000912:Antibodies, Neoplasm / Q000096:biosynthesis; D000917:Antibody Formation; D003520:Cyclophosphamide / Q000008:administration & dosage / Q000627:therapeutic use*; D004305:Dose-Response Relationship, Drug; D008748:Methylcholanthrene; D051379:Mice; D008810:Mice, Inbred C57BL; D012513:Sarcoma, Experimental / Q000139:chemically induced / Q000188:drug therapy* / Q000276:immunology
chemical_list: D000912:Antibodies, Neoplasm; D008748:Methylcholanthrene; D003520:Cyclophosphamide