title: Atopic skin test re-evaluated. III. The wheal: flare ratio, the log-dose response curve and the bio-assay of allergen extracts.
abstract: It is demonstrated that the sum of the length and width of the flare is linearly correlated with the logarithm of the sum of the length and width of the wheal; on this basis a valuable "skin-reaction index" is proposed. Furthermore, the log-dose response curve of the skin reaction, at least in the medium-sized reactions, proved to be a straight line. These methods permit a bio-assay of allergens extracts giving a maximal dispersion of 100% above and below the exact value. Coefficient of variation: 62%.
mesh_terms: D000485:Allergens; D001681:Biological Assay; D004305:Dose-Response Relationship, Drug; D006801:Humans; D008433:Mathematics; D006255:Rhinitis, Allergic, Seasonal / Q000276:immunology; D012882:Skin Tests
chemical_list: D000485:Allergens