Thallium-201 for myocardial imaging.  Relation of thallium-201 to regional myocardial perfusion.
Following intravenous administration, the myocardial concentration of tracer thallium-201, potassium-43, and rubidium-81 were determined in mice; thallium was present in the greatest concentration in the myocardium (2.08% compared 1.25% for potassium and 1.15% for rubidium at 10 minutes). The regional myocardial distribution of thallium-201 was determined in dogs under conditions of normal flow, and total occlusion, and compared with potassium-43 (r=0.97). The regional distribution of thallium-201 was compared to microspheres under conditions of partial occlusion and reactive hyperemia (r=0.97). Thallium-201 was evaluated in a series of phantom scans, which demonstrated that the low energy X-ray of thallium was suitable for imaging. These results suggest that thallium-201 can be used for the evaluation of the distribution of regional myocardial perfusion.
D000818:Animals; D003326:Coronary Circulation; D003327:Coronary Disease / Q000175:diagnosis*; D004285:Dogs; D051379:Mice; D008863:Microspheres; D009206:Myocardium / Q000378:metabolism*; D011194:Potassium Isotopes; D011877:Radionuclide Imaging / Q000379:methods*; D012413:Rubidium; D013326:Strontium Radioisotopes; D013793:Thallium / Q000378:metabolism
D011194:Potassium Isotopes; D013326:Strontium Radioisotopes; D013793:Thallium; D012413:Rubidium