The effects of methylprednisolone on oxygenation in experimental hypoxemic respiratory failure.
Methylprednisolone administration in dogs with oleic acid-induced pulmonary edema increases survival rate, cardiac output, oxygen delivery, and peripheral capillary Po2 compared to untreated dogs with edema. In addition, there is evidence that steroid treatment brings about a more favorable relationship between ventilation and perfusion but this effect takes a longer time than those dependent on cardiac output. There is mounting evidence from this and other studies that steroids represent a rational form of treatment at least for some forms of hypoxemic respiratory failure.
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D002302:Cardiac Output / Q000187:drug effects; D004285:Dogs; D000860:Hypoxia / Q000188:drug therapy; D008775:Methylprednisolone / Q000494:pharmacology / Q000627:therapeutic use*; D009829:Oleic Acids / Q000494:pharmacology / Q000627:therapeutic use*; D012131:Respiratory Insufficiency / Q000188:drug therapy*
D009829:Oleic Acids; D008775:Methylprednisolone