Complications associated with membrane lung support by venoarterial perfusion.
A series of patients supported with long-term venoarterial perfusion is presented. Gas exchange was achieved with a membrane oxygenator at flows usually in excess of 50% of the patient's baseline cardiac output. Perfusions were maintained for 7 to 12 days. Two major complications were encountered: thromboembolic myocardial infarction and liquefaction necrosis of the lung. Possible etiologies and suggestions for prevention are discussed.
D000293:Adolescent; D000328:Adult; D001921:Brain / Q000098:blood supply; D004617:Embolism / Q000209:etiology*; D005112:Extracorporeal Circulation; D005260:Female; D006801:Humans; D007238:Infarction / Q000209:etiology; D008171:Lung Diseases / Q000209:etiology*; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000209:etiology; D009336:Necrosis; D010107:Oxygenators, Membrane / Q000009:adverse effects*; D011247:Pregnancy; D012131:Respiratory Insufficiency / Q000628:therapy