Exchange transfusion in hepatic coma: factors affecting results, with long-term follow-up data.
1. Exchange transfusion in our experience has produced a response in 42 per cent of the patients. 2. Complicating factors, primarily sepsis, have been responsible for a 50 per cent mortality in those patients who initially respond, yielding a survival rate of 21 per cent. 3. In a select group of patients with infectious hepatitis under the age of twenty-five years, the survival rate was 37.5 per cent. 4. Excess bilirubin and ammonia rebound after exchange transfusions indicates a grave prognosis. 5. All survivors have normal results on liver function studies.
D000293:Adolescent; D000328:Adult; D000368:Aged; D000641:Ammonia / Q000097:blood; D001663:Bilirubin / Q000097:blood; D001706:Biopsy; D056486:Chemical and Drug Induced Liver Injury / Q000150:complications; D002648:Child; D005078:Exchange Transfusion, Whole Blood / Q000379:methods; D005260:Female; D005500:Follow-Up Studies; D006221:Halothane / Q000009:adverse effects; D006501:Hepatic Encephalopathy / Q000209:etiology / Q000401:mortality / Q000473:pathology / Q000628:therapy*; D006506:Hepatitis A / Q000150:complications; D006801:Humans; D007538:Isoniazid / Q000009:adverse effects; D008099:Liver / Q000187:drug effects / Q000473:pathology; D008103:Liver Cirrhosis / Q000150:complications; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D018805:Sepsis / Q000401:mortality
D000641:Ammonia; D001663:Bilirubin; D006221:Halothane; D007538:Isoniazid