title: Arterialization of the liver in combination with a portacaval shunt in the dog.
abstract: A dog preparation has been developed combining an end-to-side portacaval shunt with arterialization of the hepatic portion of the portal vein through an anastomosis between the inferior branch of the splenic artery and the stump of the portal vein. In this dog preparation, total hepatic blood flow, perfusion of the intrahepatic portal vein, and sinusoidal pressure remained within the preoperative range in the majority of the dogs. The data presented indicate that arterialization of the liver, under those conditions, resulted in no histologic damage or atrophy of the parenchyma of the liver and was effective in achieving significant prolongation of life and prevention of most of the adverse metabolic sequelae that follow a portacaval shunt in dogs. The indocyanine green extraction was restored to normal. The extraction of ammonia was impaired in all dogs with shunts; however, a significantly better ammonia extraction was seen in dogs with arterialization of the liver. It is being postulated that the dual perfusion of the liver through the hepatic artery and the portal vein is essential for the maintenance of the normal morphologic and functional states of the liver in dogs. The avoidance of hyperfusion of the sinusoidal bed with arterial blood is the most critical factor in preventing morphologic damage of the liver if arterialization of the portal vein is used.
mesh_terms: D000641:Ammonia / Q000097:blood; D000643:Ammonium Chloride / Q000097:blood; D000818:Animals; D001166:Arteriovenous Shunt, Surgical / Q000401:mortality; D001707:Biopsy, Needle; D001835:Body Weight; D001927:Brain Diseases / Q000209:etiology; D004285:Dogs; D006503:Hepatic Veins / Q000502:physiology; D007208:Indocyanine Green; D008099:Liver / Q000033:anatomy & histology; D008102:Liver Circulation; D011167:Portacaval Shunt, Surgical / Q000401:mortality; D011169:Portal Vein / Q000502:physiology / Q000601:surgery*; D012039:Regional Blood Flow; D013156:Splenectomy; D013157:Splenic Artery / Q000601:surgery*; D013997:Time Factors; D014690:Venous Pressure
chemical_list: D000643:Ammonium Chloride; D000641:Ammonia; D007208:Indocyanine Green