Late seroconversion following HPV-77, DE5 rubella virus vaccine.
The HAI antibody responses to HPV-77, DE5 rubella virus vaccine were evaluated with respect to time in 258 rubella-susceptible children. Seroconversion after 28 days post inoculation with this vaccine was not uncommon. These findings indicate a greater degree of modification of the HPV-77, DE5 rubella virus vaccine since most vaccines have been shown to seroconvert by 28 or 30 days post inoculation with the HPV-77 and other HPV-77 derived rubella vaccines. With respect to the routine of inoculating rubella-susceptible women in the childbearing age, late seroconversion could be of importance because of this uncertainty of the time of viremia and the increased chane of pregnancy with increasing time following immunization. Comparative information is needed for the Cendehill and candidate RA 27/3 rubella virus vaccines. That vaccine showing an early and predictable higher conversion ratio would be the most desirable for use in the above population.
D000914:Antibodies, Viral / Q000032:analysis; D000917:Antibody Formation; D002675:Child, Preschool; D003168:Complement Fixation Tests; D005260:Female; D006385:Hemagglutination Inhibition Tests; D006801:Humans; D007223:Infant; D008297:Male; D012409:Rubella / Q000517:prevention & control*; D012411:Rubella Vaccine; D012412:Rubella virus / Q000276:immunology; D013997:Time Factors; D014611:Vaccination; D014613:Vaccines, Attenuated
D000914:Antibodies, Viral; D012411:Rubella Vaccine; D014613:Vaccines, Attenuated