[Activity of certain blood enzymes in patients with myocardial infarct complicated by shock].
The activity of glutamino-oxaloacetic transaminase was studied in 85 and that of creatinophosphokinase, total lactate-dehydrogenase and its isoenzymes in 58 patients with macrofocal myocardial infarction complicated by a shock. The maximal transaminase activity in patients with myocardial infarction attended by a shock was on the average greater than in similar patients without any shock. In patients with myocardial infarction attended by a shock who presented, at the same time, congestive manifestations in the systemic ciruclation demonstrated a higher transaminase activity and its normalization at a later date than this was in the case of patients with a shock, but without congestion in the systemic circulation. In patients suffering from myocardial infarction with a shock the activity of creatinophosphokinase and total lactate-dehydrogenase averaged higher than in those without shock. In the blood serum of such patients the proportions of the lactate-dehydrogenase isoenzymes were found to undergo substantial changes, which consisted in an increased activity of the LDH1 and LDH5 fractions. The main factor responsible for a considerable rise in the activity of the blood serum transaminase, creatinophosphokinase, total lactate-dehydrogenase and the LDH1 fraction occurring in patients with myocardial infarction attended by a shock is the great extent of the necrotic focus in the myocardium.
D000328:Adult; D000368:Aged; D001219:Aspartate Aminotransferases / Q000097:blood; D003402:Creatine Kinase / Q000097:blood; D005260:Female; D006801:Humans; D007527:Isoenzymes / Q000097:blood; D007770:L-Lactate Dehydrogenase / Q000097:blood; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000097:blood / Q000150:complications / Q000201:enzymology*; D012770:Shock, Cardiogenic / Q000097:blood / Q000150:complications / Q000201:enzymology*
D007527:Isoenzymes; D007770:L-Lactate Dehydrogenase; D001219:Aspartate Aminotransferases; D003402:Creatine Kinase
Aktivnost' nekotorykh syvorotochnykh fermentov u bol'nykh infarktom miokarda, oslozhnennym shokom