title: Studies on the function of the denervated rabbit ovary: human chorionic gonadotropin-induced ovulation.
abstract: The described method for selective sympathetic denervation of the in vivo rabbit ovary involved stripping the ovarian artery of its nerve bundles and adventitial tissue. The ovary was then entirely free of fluorescent-staining adrenergic nerves. This technique was used to study the effects of ovarian denervation on HCG-induced ovulation. After HCG was administered to 22 rabbits which had previously undergone unilateral ovarian denervation, the ovaries were observed for follicular maturation and rupture. Control ovaries demonstrated a mean of 5.6 stimulated follicles/ovary; denervated ovaries had a mean of 5.4. An average of 3.5 follicles/control ovary ruptured; an average of 3.1 follicles/denervated ovary ruptured. Furthermore, the time course of ovulation after HCG did not differ between denervated and intact ovaries. These results indicate that HCG-induced ovulation in the rabbit is not interrupted by ovarian denervation.
mesh_terms: D000818:Animals; D006063:Chorionic Gonadotropin / Q000008:administration & dosage*; D003714:Denervation; D005260:Female; D006801:Humans; D007275:Injections, Intravenous; D009413:Nerve Fibers, Myelinated / Q000166:cytology; D010053:Ovary / Q000166:cytology / Q000294:innervation* / Q000502:physiology; D010060:Ovulation / Q000187:drug effects*; D011817:Rabbits; D013564:Sympathetic Nervous System / Q000166:cytology; D013997:Time Factors
chemical_list: D006063:Chorionic Gonadotropin