Drug induced hypersensitivity nephritis.
Drug-induced hypersensitivity nephritis may show several histological and clinical patterns. In most of these microscopic vascular involvement of the kidney seems to be very frequent. On immunofluorescence, deposits of C3 in mesangium and in arterioles were observed in almost all cases, independently of histological features on light microscopy. The pointing out of clinico-histological relationship seems to be the best rational approach to diagnosis of these conditions.
D000328:Adult; D000368:Aged; D000667:Ampicillin; D003176:Complement C3 / Q000378:metabolism; D003181:Complement C4 / Q000378:metabolism; D004342:Drug Hypersensitivity / Q000150:complications* / Q000473:pathology; D005260:Female; D005455:Fluorescent Antibody Technique; D005921:Glomerulonephritis / Q000209:etiology; D006801:Humans; D007074:Immunoglobulin G / Q000378:metabolism; D007075:Immunoglobulin M / Q000378:metabolism; D007678:Kidney Glomerulus / Q000276:immunology / Q000473:pathology; D008297:Male; D008712:Methicillin; D008875:Middle Aged; D009393:Nephritis / Q000209:etiology* / Q000473:pathology; D009395:Nephritis, Interstitial / Q000209:etiology; D012293:Rifampin
D003176:Complement C3; D003181:Complement C4; D007074:Immunoglobulin G; D007075:Immunoglobulin M; D000667:Ampicillin; D008712:Methicillin; D012293:Rifampin