Comparison between the bronchodilator and cardiovascular effects of inhaling 0.5 mg. rimiterol ('Pulmadil') and 0.2 mg. salbutamol.
A comparison between the acute effects of rimiterol (0.5 mg) and salbutamol (0.2 mg.) has been made using metered dose aerosols. In this dosage it was found that the peak effect of the two drugs was the same but that the effect of rimiterol was less prolonged than that of sulbutamol. No increase in blood pressure occurred and heart rate changes were minimal after both drugs. Rimiterol is an acceptable alternative to the short-acting isoprenaline but lacks the cardiovascular effects of isoprenaline and is an alternative to salbutamol where very prolonged action is unnecessary.
D000328:Adult; D000336:Aerosols; D000402:Airway Obstruction / Q000188:drug therapy; D000420:Albuterol / Q000494:pharmacology*; D001249:Asthma / Q000188:drug therapy; D001794:Blood Pressure / Q000187:drug effects; D001980:Bronchi / Q000187:drug effects*; D001991:Bronchitis / Q000188:drug therapy; D001993:Bronchodilator Agents / Q000494:pharmacology; D002319:Cardiovascular System / Q000187:drug effects*; D002396:Catechols / Q000031:analogs & derivatives* / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D005260:Female; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D007545:Isoproterenol / Q000494:pharmacology; D008297:Male; D000432:Methanol / Q000031:analogs & derivatives / Q000494:pharmacology; D008875:Middle Aged; D010880:Piperidines / Q000494:pharmacology*; D012129:Respiratory Function Tests; D012138:Respiratory Therapy
D000336:Aerosols; D001993:Bronchodilator Agents; D002396:Catechols; D010880:Piperidines; C084590:rimiterol; D007545:Isoproterenol; D000420:Albuterol; D000432:Methanol