Effects of topical and general anesthetic agents on tracheal mucous velocity of sheep.
Tracheal mucous velocity was estimated in eleven sheep by means of cine-bronchofiberscopic technique in which Teflon discs placed on the tracheal mucosa were filmed as markers. The procedure was done using a transnasal approach in conscious nonanesthetized sheep, and in the same sheep using topical and/or general anesthetic agents. The average mucous velocity in conscious sheep was 17.3 plus or minus 6.2 (SD) mm/min; in sheep anesthetized with intravenous pentobarbital or thioamylal, the average velocity was significantly depressed to 11.1 plus or minus 3.6 mm/min. No Significant differences in tracheal mucous velocity were found when 10 ml of 2 percent lidocaine was instilled into the tracheas of either conscious sheep or sheep under general anesthesia. Sheep as an animal model appear to be ideal in the study of the responses of tracheal mucous velocity to physical and chemical agents since they tolerate bronchofiberscopy quite well without the use of topical or general anesthetic agents. The basis for the depression of tracheal mucous velocity by barbiturates cannot be ascertained from the present study but the model should be useful for comparing different types of anesthetic agents.
D000768:Anesthesia, General; D000779:Anesthetics, Local / Q000494:pharmacology*; D000818:Animals; D001999:Bronchoscopy; D005336:Fiber Optic Technology; D008012:Lidocaine / Q000494:pharmacology; D009093:Mucus / Q000187:drug effects*; D010424:Pentobarbital / Q000494:pharmacology; D012756:Sheep / Q000502:physiology*; D013997:Time Factors; D014132:Trachea / Q000502:physiology*
D000779:Anesthetics, Local; D008012:Lidocaine; D010424:Pentobarbital