Measurement of fibrinogen-fibrin-related antigen in serum as aid to diagnosis of deep vein thrombosis in outpatients.
A study of serum levels of fibrinogen-fibrin-related antigen (F.R.-antigen) in outpatients presenting with clinical features suggesting deep vein thrombosis was undertaken. A raised serum level of this antigen (greater than 12 mg/1) is strong evidence in favour of the diagnosis of deep vein thrombosis. It is virtually conclusive evidence if other known causes of a raised level of the antigen are absent. On the other hand, a normal serum level of F.R.-antigen does not exclude even extensive thrombosis, and other objective techniques are required to substantiate the diagnosis.
D000328:Adult; D000941:Antigens / Q000032:analysis*; D005260:Female; D005337:Fibrin / Q000276:immunology*; D005340:Fibrinogen / Q000276:immunology*; D006801:Humans; D007841:Latex Fixation Tests; D007866:Leg / Q000098:blood supply; D008297:Male; D008875:Middle Aged; D010044:Outpatient Clinics, Hospital; D011655:Pulmonary Embolism / Q000150:complications; D013924:Thrombophlebitis / Q000150:complications / Q000175:diagnosis* / Q000276:immunology
D000941:Antigens; D005337:Fibrin; D005340:Fibrinogen