[Formation of a secondary adrenaline-heparin-fibrinogen complex and its properties].
An effect of increase in fibrinolytic activity of adrenaline-heparin (ADH) complex was studied under its incubation in a mixture with pure fibrinogen on unstablized plates of fibrin in presence of xi-aminocapronic acid, By means of spectrophotometry in UV-light an increase in lytic activity of the incubated mixture of adrenaline-heparin complex with fibrinogen was shown to be due to formation of a secondary complex, which included adrenaline, heparin and fibrinogen. After intravenous administration of a mixture of ADH complex with fibrinogen, containing products of interaction of adrenaline, heparin and fibrinogen, not only an increase in non-enzymic fibrinolytic activity of plasma occurred, but also an increase in duration of an effect of adrenaline--heparin--fibrinogen complex was observed in vivo as compared with the equivalent dose of the ADH complex
D000614:Aminocaproates / Q000494:pharmacology; D000818:Animals; D001777:Blood Coagulation / Q000187:drug effects; D004347:Drug Interactions; D004591:Electrophoresis, Polyacrylamide Gel; D004837:Epinephrine / Q000494:pharmacology*; D005340:Fibrinogen / Q000494:pharmacology*; D006461:Hemolysis / Q000187:drug effects; D006493:Heparin / Q000494:pharmacology*; D066298:In Vitro Techniques; D007275:Injections, Intravenous; D008297:Male; D051381:Rats; D012996:Solutions; D013054:Spectrophotometry, Atomic; D013055:Spectrophotometry, Infrared; D013056:Spectrophotometry, Ultraviolet; D013916:Thrombelastography; D014461:Ultracentrifugation
D000614:Aminocaproates; D012996:Solutions; D005340:Fibrinogen; D006493:Heparin; D004837:Epinephrine
Obrazovanie vtorichnogo kompleksa adrenalin-geparin-fibrinogen i ego svoĭstva