Differential effects of amphetamine and food deprivation of self-stimulation of the lateral hypothalamus and medial frontal cortex.
Intracranial self-stimulation of the lateral hypothalamus of the rat was markedly increased by d-amphetamine administration and by food deprivation. In contrast, similar self-stimulation response rates obtained in the same animals from the medial frontal cortex were unaffected by food deprivation and only slightly increased by d-amphetamine administration. Furthermore, a large difference between d- vs. l-amphetamine on response rate was obtained for lateral hypothalamic but not for medial frontal cortex self-stimulation. The results of this study were consistent with a noradrenergic self-stimulation system for the lateral hypothalamus. Medial frontal cortex self-stimulation, however, appears to be mediated by a neuroanatomical and neurochemical system different from that of the lateral hypothalamus.
D000661:Amphetamine / Q000494:pharmacology*; D000818:Animals; D002540:Cerebral Cortex / Q000187:drug effects / Q000502:physiology* / Q000648:ultrastructure; D003913:Dextroamphetamine / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D005508:Food Deprivation; D007031:Hypothalamus / Q000187:drug effects / Q000502:physiology* / Q000648:ultrastructure; D008297:Male; D051381:Rats; D012653:Self Stimulation; D013997:Time Factors
D000661:Amphetamine; D003913:Dextroamphetamine