Genetic polymorphism of properdin factor B in the rhesus: evidence for single subunit structure in primates.
Properdin Factor B shows genetic polymorphism in the human and the polymorphic patterns in agarose gel electrophoresis suggest a tetrameric structure. Factor B polymorphism in the rhesus monkey has been demonstrated in the present study to be genetically determined and under the control of a single autosomal locus, rhesus Bf. Six codominant alleles, Bf-F, Bf-G-1, Bf-G-2, Bf-S-1, Bf-S-2 have been recognized and the first five have been shown to have gene frequencies of 0.307,0.160,0.016,0.377, and 0.139. The electrophoretic appearance of the polymorphic patterns does not suggest a tetrameric structure in the rhesus. Structural studies show purified human factor B to exist as a single subunit of molecular weight 94,000 daltons so that a tetrameric structure appears highly unlikely.
D000818:Animals; D000936:Antigen-Antibody Complex; D000937:Antigen-Antibody Reactions; D004586:Electrophoresis; D004591:Electrophoresis, Polyacrylamide Gel; D005260:Female; D005787:Gene Frequency; D014644:Genetic Variation; D006041:Goats / Q000276:immunology; D007106:Immune Sera; D007122:Immunoelectrophoresis; D007125:Immunogenetics; D008253:Macaca mulatta; D008297:Male; D008970:Molecular Weight; D011110:Polymorphism, Genetic; D011323:Primates / Q000276:immunology*; D011414:Properdin; D011487:Protein Conformation; D012685:Sepharose
D000936:Antigen-Antibody Complex; D007106:Immune Sera; D011414:Properdin; D012685:Sepharose