[A comparative clinico-genetic study of attack-like schizophrenia with late and early manifestation with regard to age].
The author studied the genetical traits in 2 groups of probands with attack-like schizophrenia with corresponding sex and age. The 1st group (62 probands) consisted of cases where the average age of the manifest psychoses was 59.5. The second group consisted of cases with an average of the manifest psychoses of 30.9. It appeared that the morbidity risk for schizophrenia for all the relatives of the first degree of relationship in the families of patients with late attack-like schizophrenia is significantly lower than the morbidity risk in familiies with an onset in young age. At the same time the frequency of schizophrenia among the relatives of patients with late attack-like schizophrenia significantly exceeds the frequency of schizophrenia in the general population. An accumulation of psychoses of a different nozology was not observed. The frequency of schizophrenia among the parents and sibs in a late manifestation of the disease in the probands is lower than in early schizophrenia. These differences were not seen in the children. Among the relatives of patients with late and early attack-like schizophrenia there is a large amount of schizoid personality anomalies.
D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000368:Aged; D000437:Alcoholism / Q000235:genetics; D001714:Bipolar Disorder / Q000235:genetics; D004827:Epilepsy / Q000235:genetics; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D019965:Neurocognitive Disorders / Q000235:genetics; D010259:Paranoid Disorders / Q000235:genetics; D010375:Pedigree; D011618:Psychotic Disorders / Q000235:genetics; D012306:Risk; D012557:Schizoid Personality Disorder / Q000235:genetics; D012559:Schizophrenia / Q000175:diagnosis / Q000235:genetics*; D013405:Suicide
Sravnitel'noe kliniko-geneticheskoe issledovanie pristupoobraznoĭ shizofrenii s pozdnim i rannim vozrastom manifestatsii