The effects of methylphenidate and haloperidol on the heart rate and blood pressure of hyperactive children with special reference to time of action.
Twelve hyperactive-aggressive children were given single acute doses of placebo, methylphenidate (0.3 mg/kg) and haloperidol (0.035 mg/kg) on three separate occasions in a double blind crossover design with drug order randomized across subjects. Resting heart rates and systolic and diastolic blood pressures were obtained at nine intervals up to 7 hrs and electrocardiograms at 150 min after ingestion. Methylphenidate caused a small trend toward an increment in heart rate and a significant increment in blood pressure, while the changes with haloperidol were minimal. There were no EKG changes. Changes in heart rate were of a minimal nature as compared with those occurring with digestion which tended to obscure drug effects.
D000704:Analysis of Variance; D001794:Blood Pressure / Q000187:drug effects*; D002648:Child; D002986:Clinical Trials as Topic; D004063:Digestion; D005260:Female; D006220:Haloperidol / Q000494:pharmacology*; D006339:Heart Rate / Q000187:drug effects*; D006801:Humans; D006948:Hyperkinesis / Q000503:physiopathology*; D008297:Male; D008774:Methylphenidate / Q000494:pharmacology*; D013268:Stimulation, Chemical; D013997:Time Factors
D008774:Methylphenidate; D006220:Haloperidol