Pilocarpine toxicity. Effects on the rabbit corneal endothelium.
The effects of pilocarpine on the healthy rabbit corneal endothelium were studied by in vitro perfusion, photography, and electron microscopy. The toxicity of endothelial cells to pilocarpine was doserelated. Photography showed shrinkage of cells exposed to pilocarpine. The most striking ultrastructure changes were margination of nuclear heterochromatin and cytoplasmic vacuolation.
D000818:Animals; D003315:Cornea / Q000187:drug effects* / Q000473:pathology; D004305:Dose-Response Relationship, Drug; D004727:Endothelium / Q000187:drug effects / Q000473:pathology; D004847:Epithelial Cells; D004848:Epithelium / Q000473:pathology; D005260:Female; D008297:Male; D008854:Microscopy, Electron; D010477:Perfusion; D010781:Photography; D010862:Pilocarpine / Q000633:toxicity*; D011817:Rabbits; D013997:Time Factors
D010862:Pilocarpine