Nonspecificity in the divalent cation antagonism of dihydrostreptomycin action on Mycobacterium smegmatis.
A divalent cation-dependent antagonism of dihydrostreptomycin action on Mycobacterium smegmatis was demonstrated. However, the nutritionally nonessential cations Sr++ and Ba++ inhibited drug action as effectively as the essential ions Mg++ and Ca++, indicating a high degree of nonspecificity.
D001464:Barium / Q000494:pharmacology; D002118:Calcium / Q000494:pharmacology; D003470:Culture Media; D008274:Magnesium / Q000494:pharmacology; D008670:Metals / Q000494:pharmacology*; D009161:Mycobacterium / Q000187:drug effects*; D013307:Streptomycin / Q000031:analogs & derivatives* / Q000037:antagonists & inhibitors; D013324:Strontium / Q000494:pharmacology
D003470:Culture Media; D008670:Metals; D001464:Barium; D008274:Magnesium; D002118:Calcium; D013307:Streptomycin; D013324:Strontium