Galactosamine- "hepatitis" in rats with different phagocytic activity of liver RES.
Morphological investigations by lightmicroscopy were performed to evaluate the influence of an altered liver RES-function state on the course of Gal-N-hepatitis. There was a good correlation between the biochemical data and the morphological alterations. The simultaneous infusion of Gal-N 1 g/kg b.w. and carbon particles (2.6 mg/100 g b.w) into the portal vein was followed by subtotal necrosis of the liver and Sanarelli-Shwartzmann-phenomenon. Signs of RES-activity were nearly absent. 8 days after pretreatment with carbon, Gal-N application did not produce Gal-N hepatitis; 21 days after carbon infusion the morphological changes normally found after Gal-N application were present. The morphological studies confirm the concept that an altered RES-function state is a very important factor for the development of liver cell necrosis.
D000818:Animals; D002244:Carbon / Q000494:pharmacology; D056486:Chemical and Drug Induced Liver Injury / Q000209:etiology / Q000503:physiopathology* / Q000517:prevention & control; D005688:Galactosamine; D007281:Ink; D007728:Kupffer Cells; D008099:Liver / Q000503:physiopathology*; D012157:Mononuclear Phagocyte System / Q000503:physiopathology*; D009336:Necrosis; D010587:Phagocytosis; D011292:Premedication; D051381:Rats; D011919:Rats, Inbred Strains; D012790:Shwartzman Phenomenon; D013997:Time Factors
D002244:Carbon; D005688:Galactosamine