title: Double heterozygosity for hemoglobin Camden (beta 131 Gln yields Glu) and hemoglobin S in an American negro.
abstract: A hemoglobin variant with the slightly fast mobility associated with K hemoglobins was found, together with hemoglobin S, in an apparently healthy 3-year-old Negro girl from Washington, D.C. Her father had the same variant, along with hemoglobin A, and her mother had hemoglobins A plus S. Respective proportions of hemoglobins K and S in the propositus were 66-34. The K variant now has been found to have the structural change Gln yields Glu at position beta-131 (beta-H9); therefore it apparently is identical to hemoglobin Camden reported in trait form in a Negro subject by YATES, BELLINGHAM and HUEHNS (Nature 243: 467-468, 1973).
mesh_terms: D044383:Black People; D002675:Child, Preschool; D002918:Chymotrypsin; D004592:Electrophoresis, Starch Gel; D005260:Female; D005973:Glutamine / Q000032:analysis; D006451:Hemoglobin, Sickle / Q000032:analysis*; D006453:Hemoglobinopathies / Q000235:genetics*; D006455:Hemoglobins, Abnormal / Q000032:analysis*; D006461:Hemolysis; D006579:Heterozygote; D006801:Humans; D010455:Peptides / Q000032:analysis; D014357:Trypsin
chemical_list: D006451:Hemoglobin, Sickle; D006455:Hemoglobins, Abnormal; D010455:Peptides; D005973:Glutamine; D002918:Chymotrypsin; D014357:Trypsin