Potassium canrenoate in the treatment of long-term digoxin-induced arrhythmias in conscious dogs.
The effects of potassium canrenoate on arrhythmias induced by long-term progressive digoxin toxicity were studied in eight conscious beagle dogs. Sinus bradycardia and sinoatrial block, as well as atrioventricular (A-V) conduction disturbances, were consistently alleviated by administration of potassium canrenoate. Premature supraventricular (including junctional) and ventricular depolarizations as well as ventricular tachycardias were also suppressed. Although potassium canrenoate always terminated the digitalis-induced arrhythmias, it usually converted the rhythm to sinus arrhythmia rather than to normal sinus rhythm. Equimolar sodium canrenoate, but not potassium chloride, had similar reversal effects on arrhythmias induced by long-term digoxin intoxication. These data indicate that canrenoate, a diuretic agent with reported positive inotropic effects, may be useful in the treatment of digitalis-induced arrhythmias in man.
D000818:Animals; D001146:Arrhythmia, Sinus / Q000188:drug therapy; D001145:Arrhythmias, Cardiac / Q000139:chemically induced / Q000188:drug therapy; D001283:Atrioventricular Node / Q000503:physiopathology; D001919:Bradycardia / Q000188:drug therapy; D002036:Bundle of His / Q000503:physiopathology; D004077:Digoxin; D004232:Diuretics / Q000494:pharmacology / Q000627:therapeutic use*; D004285:Dogs; D004562:Electrocardiography; D005260:Female; D006327:Heart Block / Q000188:drug therapy; D006352:Heart Ventricles / Q000187:drug effects; D007664:Ketosteroids / Q000627:therapeutic use; D008297:Male; D000451:Mineralocorticoid Receptor Antagonists; D011188:Potassium / Q000627:therapeutic use; D011189:Potassium Chloride / Q000627:therapeutic use; D011245:Pregnadienes / Q000627:therapeutic use*; D012964:Sodium / Q000627:therapeutic use; D013610:Tachycardia / Q000188:drug therapy
D004232:Diuretics; D007664:Ketosteroids; D000451:Mineralocorticoid Receptor Antagonists; D011245:Pregnadienes; D011189:Potassium Chloride; D004077:Digoxin; D012964:Sodium; D011188:Potassium