Histopathology of the endocrine pancreas of a fresh-water fish, Clarias batrachus (L.). V. Effect of epinephrine administration.
Intramuscular administration of epinephrine in 2 mg/kg and 5 mg/kg body weight doses to Clarias batrachus caused significant hyperglycemia between 12 and 18 h after treatment. The hormone produced a small decrease in the liver glycogen, but induced a notable fall in the glycogen of muscles and a transient increase in the brain glycogen. Light-microscopical examination of the pancreatic islets revealed degranulation and vacuolization of the beta-cells accompanied by acute necrosis. Damage to the alpha-cells was also noticed in hyperglycemic fish. The changes in the cellular configuration of the islets, blood glucose and on the tissue glycogen contents were dose-dependent. It is suggested that epinephrine alters the carbohydrate metabolism through the alpha-cells of the islets.
D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D001921:Brain / Q000378:metabolism; D004837:Epinephrine / Q000008:administration & dosage / Q000494:pharmacology*; D005260:Female; D005399:Fishes / Q000033:anatomy & histology*; D005618:Fresh Water; D006003:Glycogen / Q000378:metabolism; D006943:Hyperglycemia / Q000139:chemically induced; D007515:Islets of Langerhans / Q000166:cytology* / Q000187:drug effects / Q000378:metabolism; D008112:Liver Glycogen / Q000378:metabolism; D008297:Male; D009132:Muscles / Q000378:metabolism
D001786:Blood Glucose; D008112:Liver Glycogen; D006003:Glycogen; D004837:Epinephrine