Adrenaline-induced cardiovascular changes after intrahypothalamic administration to rats.
Adrenaline caused a decrease in arterial blood pressure and heart rate when injected into the anterior thalamic region of rats. The size and the duration of these effects depended upon the dose of adrenaline injected. Adrenaline is 10 times more potent than noradrenaline in inducing these intrahypothalamic effects on cardiovascular parameters. These data support the concept of the relevance of adrenaline receptors in central autonomic regulation.
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D003864:Depression, Chemical; D004837:Epinephrine / Q000008:administration & dosage / Q000494:pharmacology*; D006339:Heart Rate / Q000187:drug effects; D006439:Hemodynamics / Q000187:drug effects*; D007031:Hypothalamus; D007267:Injections; D008297:Male; D051381:Rats; D013268:Stimulation, Chemical; D013997:Time Factors
D004837:Epinephrine