title: [Spontaneous regression and leukoderma in malignant melanoma].
abstract: In four patients with superficial spreading melanoma, partial spontaneous regression and/or leukodermas of different appearance occurred. In two patients leukoderma appeared within the central area of the primary tumor; one of whom developed, in addition, vitiligo elsewhere on the body. In a further case the melanoma exhibited a depigmented halo resembling Sutton's nevus. Presumably, these leukodermas represent an epiphenomenon of the specific immunological reaction between the host and the melanoma.
mesh_terms: D000328:Adult; D006801:Humans; D008297:Male; D008543:Melanins; D008545:Melanoma / Q000276:immunology / Q000473:pathology* / Q000601:surgery; D008875:Middle Aged; D009365:Neoplasm Regression, Spontaneous; D009506:Nevus / Q000276:immunology / Q000473:pathology; D010859:Pigmentation Disorders / Q000473:pathology; D011379:Prognosis; D012878:Skin Neoplasms / Q000276:immunology / Q000473:pathology* / Q000601:surgery; D014820:Vitiligo / Q000276:immunology / Q000473:pathology*
chemical_list: D008543:Melanins
vernacular_title: Spontanregression und Leukoderm beim malignen Melanom