Subcutaneous secretin in dogs: influence of solvent and volume of solvent.
Pancreatic secretion in response to subcutaneously injected secretin was studied in three dogs with chronic pancreatic and gastric fistulas. Three solvents: saline, gelatin, carboxymethylcellulose (CMC); two volumes of solvent: 2 and 6 ml; and two doses of secretin: 75 and 150 clinical units were tested. Gelatin was more effective than CMC in prolonging the action of secretin; the duration of the plateau of secretion was about twice as long with gelatin as with saline. Increasing the volume of solvent from 2 to 6 ml also increased the total duration of secretion and total HCO-3 output. It is concluded that gelatin is a suitable vehicle for prolonging the action of secretin.
D000704:Analysis of Variance; D000818:Animals; D001639:Bicarbonates / Q000032:analysis; D002266:Carboxymethylcellulose Sodium; D004285:Dogs; D005747:Gastric Fistula; D005780:Gelatin; D007279:Injections, Subcutaneous; D010185:Pancreatic Fistula; D010189:Pancreatic Juice / Q000032:analysis; D014677:Pharmaceutical Vehicles; D012633:Secretin / Q000008:administration & dosage*; D012997:Solvents; D013997:Time Factors
D001639:Bicarbonates; D014677:Pharmaceutical Vehicles; D012997:Solvents; D012633:Secretin; D005780:Gelatin; D002266:Carboxymethylcellulose Sodium