title: Subsensitivity to pilocarpine in primate ciliary muscle following topical anticholinesterase treatment.
abstract: Accommodative responses to intramuscular pilocarpine were determined in four surgically aniridic vervet monkeys, before and after eight weeks of daily unilateral topical treatment with echothiophate iodide.  The echothiophate-treated eyes maintained maximum myopia during the treatment course. However, after echotiophate treatment was stopped and the refraction had returned to baseline, a subsensitivity of the accommodative mechanism to pilocarpine became apparent.  Normal sensitivity to pilocarpine did not return until four to five months after echothiophate treatment had been stopped.
mesh_terms: D000065:Accommodation, Ocular / Q000187:drug effects; D000818:Animals; D001285:Atropine / Q000008:administration & dosage / Q000494:pharmacology; D002522:Chlorocebus aethiops; D002924:Ciliary Body / Q000187:drug effects*; D004456:Echothiophate Iodide / Q000008:administration & dosage* / Q000494:pharmacology; D005260:Female; D007273:Injections, Intramuscular; D009216:Myopia / Q000139:chemically induced; D009883:Ophthalmic Solutions; D010862:Pilocarpine / Q000008:administration & dosage / Q000494:pharmacology*; D012029:Refraction, Ocular
chemical_list: D009883:Ophthalmic Solutions; D010862:Pilocarpine; D001285:Atropine; D004456:Echothiophate Iodide