[The effect of tilidine on left-ventricular function of the human heart (author's transl)].
The effect of tilidine (Valoron, 1.5 mg/kg) on left-ventricular function was measured in ten patients undergoing diagnostic cardiac catheterization. In the course of thirty minutes after administration there was a small fall in systemic arterial pressure, decrease in cardiac output, cardiac index and stroke volume, as well as a change in the isovolumetric inotropic state. Haemodynamic and inotropic changes were small in amount, varying between 3.4 and 14.5% of basal values. This study indicates that tilidine, while having a powerful analgesic effect, has only a mild contractility-inhibiting action. Tilidine is thus a useful alternative as an analgesic in cardiac pain.
D000328:Adult; D001794:Blood Pressure / Q000187:drug effects; D006328:Cardiac Catheterization; D002302:Cardiac Output / Q000187:drug effects; D003509:Cyclohexanecarboxylic Acids / Q000494:pharmacology*; D006321:Heart / Q000187:drug effects; D006352:Heart Ventricles; D006801:Humans; D008875:Middle Aged; D009119:Muscle Contraction / Q000187:drug effects; D013993:Tilidine / Q000494:pharmacology*
D003509:Cyclohexanecarboxylic Acids; D013993:Tilidine
Die Wirkung von Tilidin auf die linksventrikuläre Dynamik des menschlichen Herzens