The effect of intravenous infusions of prostaglandins E-2 and F-2alpha on human gastric function.
The effect of intravenous infusions of prostaglandins E-2 and F(-2alpha) at various dose levels on basal, or on maximally or submaximally pentagastrin-stimulated acid secretion, was studied in 40 male subjects. Intraluminal antral pressures were also measured. Prostaglandin F (0.08 mug kg-minus 1 min-minus 1) transiently, but significantly, inhibited submaximal acid output and increased the frequency of antral contractions. Prostaglandin E(2)(0.08 mug kg-minus 1 min-minus 1) inhibited basal acid secretion.
D004415:Dyspepsia; D005750:Gastric Juice / Q000378:metabolism*; D005769:Gastrointestinal Motility / Q000187:drug effects; D006801:Humans; D007263:Infusions, Parenteral; D008297:Male; D010418:Pentagastrin / Q000494:pharmacology; D010437:Peptic Ulcer / Q000503:physiopathology; D011312:Pressure; D011453:Prostaglandins / Q000008:administration & dosage / Q000494:pharmacology*; D011458:Prostaglandins E / Q000494:pharmacology; D011460:Prostaglandins F / Q000494:pharmacology; D011706:Pyloric Antrum / Q000187:drug effects; D013270:Stomach / Q000187:drug effects*
D011453:Prostaglandins; D011458:Prostaglandins E; D011460:Prostaglandins F; D010418:Pentagastrin