Comparison of ribosomal proteins from neoplastic and non-neoplastic cells. Resolution by two-dimensional gel electrophoresis.
Functionally active mammalian membrane-free ribosomes were prepared from rat forebrain, a solid tumor (mouse neuroblastoma C-1300) and a human tumor cell-line in suspension culture (HeLa). Proteins were extracted from these ribosomes and were resolved by a newly developed. Two dimensional gel electrophoretic procedure. Although the ribosomal protein patterns from the three preparations were generally similar, there were four obvious differences between the forebrain ribosomes and the ribosomes from the two neoplastic cell types.
D000818:Animals; D001921:Brain; D004586:Electrophoresis; D006367:HeLa Cells; D006801:Humans; D051379:Mice; D008970:Molecular Weight; D009363:Neoplasm Proteins / Q000302:isolation & purification; D009447:Neuroblastoma; D051381:Rats; D012269:Ribosomal Proteins / Q000302:isolation & purification
D009363:Neoplasm Proteins; D012269:Ribosomal Proteins