[Septicemias of superinfection in resucitation. Their prevention by restriction of antibiotics].
Nosocomial septicemias supervened during the 15 trimesters following the opening of a new built critical care unit were reviewed. During the five first trimesters the incidence of nosocomial septicemias was 5.9 p.cent. It increases to 10.7 p.cent (p smaller than 0.001) during the five following trimesters. Then a drastic restriction in antibiotic administration was performed, including withdrawal of any prophylactic antibiotherapy, preferential use of penicilline G to prevent infection by Clostridium and cocci Gram positive species surinfection, and, in case of bacterial proved infection, use of a narrow spectrum adapted antibiotic for a time as short as possible. During the 5 trimesters following the application of this antibiotic restriction, the incidence of nosocomial septicemias dropped to 5.7 p.cent (p smaller than 0.001). This phenomenon was related to the lowered incidence of the Gram negative bacilli septicemias from 11.1 p.cent to 4.8 p.cent (p smaller than 0.001) while the incidence of Gram positive cocci septicemias remained unchanged. These results strongly suggest the responsibility of the overuse of antibiotics in the determination of nosocomial septicemias and the efficiency of a drastic antibiotic restriction upon the surinfection of patients hospitalized in a critical care unit.
D000900:Anti-Bacterial Agents / Q000009:adverse effects* / Q000627:therapeutic use; D001419:Bacteria; D003428:Cross Infection / Q000517:prevention & control*; D006801:Humans; D007362:Intensive Care Units; D012151:Resuscitation; D018805:Sepsis / Q000188:drug therapy / Q000517:prevention & control*
D000900:Anti-Bacterial Agents
Les septicémies de surinfection en réanimation. Leur prévention par la restriction de l'antibiothérapie