Hyperglycemic effect of amino compounds structurally related to caproate in rats.
The chronic feeding of small amounts (0.3-3% of diet weight) of certain amino derivatives of caproate resulted in hyperglycemia, an elevated glucose tolerance curve and, occasionally, glucosuria. Effective compounds included norleucine, norvaline, glutamate, epsilon-aminocaproate, methionine, and leucine.
D000596:Amino Acids / Q000008:administration & dosage / Q000009:adverse effects*; D000614:Aminocaproates / Q000009:adverse effects*; D000818:Animals; D003920:Diabetes Mellitus / Q000378:metabolism; D005951:Glucose Tolerance Test; D005971:Glutamates / Q000009:adverse effects; D006029:Glycosuria / Q000139:chemically induced; D006943:Hyperglycemia / Q000139:chemically induced*; D007930:Leucine / Q000009:adverse effects; D008297:Male; D008715:Methionine / Q000009:adverse effects; D009646:Norleucine / Q000009:adverse effects; D051381:Rats; D013329:Structure-Activity Relationship; D013997:Time Factors
D000596:Amino Acids; D000614:Aminocaproates; D005971:Glutamates; D009646:Norleucine; D008715:Methionine; D007930:Leucine