title: The dependence of the hemoglobin (beta plus gamma)/alpha chain synthetic ratio on the degree of anemia in beta-thalassemia (38561).
abstract: The peripheral blood hemoglobin (beta plus gamma)/alpha chain synthetic ratio in three homozygous beta-thalassemic subjects was shown to increase towards unity as their hematocrits were raised by stepwise transfusion.  The observation that the chain synthetic ratio can vary in a given individual is discussed in relation to current understanding about the regulation of hemoglobin synthesis.
mesh_terms: D000293:Adolescent; D000328:Adult; D000740:Anemia / Q000097:blood*; D001803:Blood Transfusion; D004906:Erythrocyte Count; D006400:Hematocrit; D006454:Hemoglobins / Q000096:biosynthesis*; D006801:Humans; D012156:Reticulocytes; D013789:Thalassemia / Q000097:blood*
chemical_list: D006454:Hemoglobins