title: Cystic fibrosis: comparison of two mucolytic drugs for inhalation treatment (acetylcysteine and arginine hydrochloride).
abstract: Clinical, bronchoscopic, spirographic, scintigraphic, and chemical analyses were done in 24 children with cystic fibrosis to assess the mucolytic effects of acetylcysteine inhalations versus L-arginine hydrochloride aerosols. The latter drug is less active than acetylcysteine and should not be used to treat children with cystic fibrosis.
mesh_terms: D000111:Acetylcysteine / Q000008:administration & dosage* / Q000627:therapeutic use; D000336:Aerosols; D001120:Arginine / Q000008:administration & dosage* / Q000627:therapeutic use; D001999:Bronchoscopy; D002245:Carbon Dioxide / Q000097:blood; D002648:Child; D002675:Child, Preschool; D003371:Cough; D003550:Cystic Fibrosis / Q000188:drug therapy* / Q000503:physiopathology; D004341:Drug Evaluation; D005100:Expectorants / Q000008:administration & dosage* / Q000627:therapeutic use; D005260:Female; D006801:Humans; D008297:Male; D009093:Mucus / Q000378:metabolism; D010100:Oxygen / Q000097:blood; D011877:Radionuclide Imaging; D012119:Respiration; D012129:Respiratory Function Tests; D013147:Spirometry; D013183:Sputum / Q000382:microbiology
chemical_list: D000336:Aerosols; D005100:Expectorants; D002245:Carbon Dioxide; D001120:Arginine; D010100:Oxygen; D000111:Acetylcysteine