Treatment of thyrotoxicosis during pregnancy with propranolol.
The treatment of two pregnant thyrotoxic patients with propranolol alone is discussed. One patient had a spontaneous remission during pregnancy wile taking propranolol. In the other patient treatment with propranolol allowed postponement of definitive therapy until after delivery, when the fetus was no longer at risk. There were no complications of therapy in either patient and both infants were normal. The use of propranolol in thyrotoxicosis is discussed and the pertinent literature is reviewed. Regional anesthesia is preferred over general anesthsia in patients taking propranolol. Patients taking propranolol who require general anesthesia for delivery should have continuous monitoring of electrocardiogram and central venous pressure. To this date no method of therapy has been free of fetal side effects. Surgical treatment is associated with occasional abortion or premature labor; antithyroid medication occasionally results in fetal goiter or cretinism.
D000293:Adolescent; D000328:Adult; D000765:Anesthesia, Conduction; D000768:Anesthesia, General; D000773:Anesthesia, Obstetrical; D001794:Blood Pressure; D005260:Female; D005318:Fetal Heart / Q000503:physiopathology; D005333:Fetus / Q000187:drug effects; D005865:Gestational Age; D006321:Heart / Q000503:physiopathology; D006801:Humans; D006980:Hyperthyroidism / Q000188:drug therapy* / Q000503:physiopathology; D008431:Maternal-Fetal Exchange; D011181:Postnatal Care; D011247:Pregnancy; D011248:Pregnancy Complications / Q000188:drug therapy* / Q000503:physiopathology; D011295:Prenatal Care; D011433:Propranolol / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*; D011674:Pulse; D012075:Remission, Spontaneous; D013960:Thyroid Function Tests; D014284:Triiodothyronine
D014284:Triiodothyronine; D011433:Propranolol