Suppression of sebaceous gland non-specific esterase activity be electrophilic alpha beta-unsaturated compounds.
Sebaceous gland non-specific esterase activity was suppressed following application to mouse skin of 2 electrophilic alpha beta-unsaturated compounds, o-chlorobenzylidenemalononitrile and beta-nitrostyrene, but not by three others.
D000447:Aldehydes / Q000494:pharmacology; D000475:Alkenes / Q000494:pharmacology; D000818:Animals; D002273:Carcinogens; D003510:Cyclohexanes / Q000494:pharmacology; D004353:Drug Evaluation, Preclinical; D004950:Esterases / Q000378:metabolism*; D005260:Female; D051379:Mice; D009570:Nitriles / Q000494:pharmacology*; D012627:Sebaceous Glands / Q000187:drug effects / Q000201:enzymology*; D013343:Styrenes / Q000494:pharmacology*; D014812:Vitamin K / Q000494:pharmacology; D009763:o-Chlorobenzylidenemalonitrile / Q000494:pharmacology*
D000447:Aldehydes; D000475:Alkenes; D002273:Carcinogens; D003510:Cyclohexanes; D009570:Nitriles; D013343:Styrenes; D014812:Vitamin K; D009763:o-Chlorobenzylidenemalonitrile; D004950:Esterases