Prophylaxis and treatment of experimental anaphylaxis in cattle by sodium meclofenamate.
Sodium meclofenamate was compared to saline for efficacy in preventing and treating experimentally induced, acute, systemic anaphylaxis in cattle. Respiratroy changes were shown to be reduced to the greatest extent. Lacrimation and collapse were not affected. The timing and routes of administration giving maximum efficacy were those which gave maximum plasma levels of the drug closest to the time of exposure of the animal to the specific antigen.
D000284:Administration, Oral; D000707:Anaphylaxis / Q000188:drug therapy / Q000517:prevention & control / Q000662:veterinary*; D000818:Animals; D000941:Antigens / Q000008:administration & dosage; D002417:Cattle; D002418:Cattle Diseases / Q000188:drug therapy / Q000517:prevention & control; D003371:Cough / Q000662:veterinary; D007275:Injections, Intravenous; D010047:Ovalbumin / Q000008:administration & dosage / Q000276:immunology; D012131:Respiratory Insufficiency / Q000662:veterinary; D012472:Salivation; D014050:Toluene / Q000031:analogs & derivatives / Q000627:therapeutic use; D062367:ortho-Aminobenzoates / Q000031:analogs & derivatives* / Q000627:therapeutic use
D000941:Antigens; D062367:ortho-Aminobenzoates; D014050:Toluene; D010047:Ovalbumin