Systemic lupus erythematosus in a 1-year-old child.
An 11-month-old girl had systemic lupus erythematosus with a widespread skin rash. She manifested five of the criteria necessary for the diagnosis: oral ulcerations, alopecia, positive lupus erythematosus preparations, convulsions, and thrombocytopenia with leukopenia. Direct immunofluorescence showed deposits of IgG and C3 at the dermoepidermal junction of both abnormal and clinically uninvolved skin, and in subepithelial deposits along the glomerular basement membrane.
D000367:Age Factors; D000505:Alopecia / Q000209:etiology; D003176:Complement C3 / Q000032:analysis; D005260:Female; D006801:Humans; D007074:Immunoglobulin G / Q000032:analysis; D007223:Infant; D007970:Leukopenia / Q000209:etiology; D008180:Lupus Erythematosus, Systemic / Q000175:diagnosis / Q000188:drug therapy / Q000276:immunology; D008856:Microscopy, Fluorescence; D009912:Oral Manifestations; D010406:Penicillins / Q000009:adverse effects / Q000627:therapeutic use; D012640:Seizures / Q000209:etiology; D012867:Skin / Q000276:immunology; D013444:Sulfisoxazole / Q000009:adverse effects / Q000627:therapeutic use; D013921:Thrombocytopenia / Q000209:etiology; D014456:Ulcer / Q000209:etiology
D003176:Complement C3; D007074:Immunoglobulin G; D010406:Penicillins; D013444:Sulfisoxazole