title: [Controlled double-blind study (SAMe-imipramine) in depressive syndromes].
abstract: Thirty one patients were treated with either S-Adenosylmethionine or Imipramine in a double-blind clinical trial comparing S-Adenosylmethionine (25 mg i.m. three times daily) with Imipramine (25 mg i.m. three times daily) administered for a period of three weeks. Hamilton Rating scores showed no significant differences between treatments, but such slight differences as were observed favoured S-Adenosylmethionine.
mesh_terms: D000284:Administration, Oral; D000328:Adult; D000368:Aged; D002986:Clinical Trials as Topic; D003863:Depression / Q000188:drug therapy*; D004341:Drug Evaluation; D005260:Female; D006801:Humans; D007099:Imipramine / Q000008:administration & dosage / Q000627:therapeutic use*; D007273:Injections, Intramuscular; D008297:Male; D008875:Middle Aged; D012436:S-Adenosylmethionine / Q000008:administration & dosage / Q000627:therapeutic use*; D013405:Suicide
chemical_list: D012436:S-Adenosylmethionine; D007099:Imipramine
vernacular_title: Studio controllato in doppio cieco (SAMe-Imipramina) nelle sindromi depressive