Plasma fibrinolytic activity following oral anabolic steroid therapy.
Six anabolic steroids were assessed for their ability to enhance plasma fibrinolytic activity in males with ischaemic heart disease. Five 17alpha-alkylated steroids (Ethyloestrenol, Norethandrolone, Methandienone, Methylandrostenediol and Oxymetholone) were examined and all produced a significant increase in plasma plasminogen activator as measured by the euglobulin lysis time. The only non-17alpha-alkylated steroid studied (Methenolone acetate) failed to enhance fibrinolysis. The 17alpha-alkylated steroids studied all deserve more detailed evaluation of their long term effects on plasma fibrinolytic activity.
D000328:Adult; D000368:Aged; D045930:Anabolic Agents / Q000494:pharmacology*; D055598:Chemical Phenomena; D002621:Chemistry; D002986:Clinical Trials as Topic; D003018:Clot Retraction; D005338:Fibrin Fibrinogen Degradation Products / Q000032:analysis; D005340:Fibrinogen / Q000032:analysis; D005342:Fibrinolysis / Q000187:drug effects*; D006801:Humans; D008111:Liver Function Tests; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000097:blood* / Q000188:drug therapy; D010960:Plasminogen Activators / Q000097:blood
D045930:Anabolic Agents; D005338:Fibrin Fibrinogen Degradation Products; D005340:Fibrinogen; D010960:Plasminogen Activators