Hypoglycemic conditioned reflex in rats: preliminary study of its mechanism.
It was found that a nervous mechanism is involved in eliciting a hypoglycemic response in rats. A conditioned reflex was established after a series of reinforcements in which an insulin injection (unconditioned stimulus) was associated with the sound of a bell (conditioning stimulus). The hypoglycemic conditioned response was statistically similar to that of insulin. The latency of the beginning of the hypoglycemic response to insulin was between 4 and 6 min. The latency of the conditioned hypoglycemic response to the conditioning stimulus was about 1 min. Blood extracted from a conditioned rat during the test of conditioning produced a hypoglycemic effect when injected into a nonconditioned receptor rat.
D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D003214:Conditioning, Classical; D005260:Female; D007003:Hypoglycemia / Q000139:chemically induced / Q000503:physiopathology*; D007328:Insulin; D051381:Rats; D012054:Reinforcement, Psychology; D013997:Time Factors
D001786:Blood Glucose; D007328:Insulin