title: Changes in the bidirectional sodium flux across the intestinal mucosa in Crohn's disease.
abstract: Bidirectional sodium flux across the intestinal mucosa was measured in a group of 10 patients with Crohn's disease treated in the past by panproctocolectomy with ileostomy and compared with a similarly treated group of 11 patients with ulcerative colitis. All of them were in good health at the time of the study and a recent radiological examination of the small intestine was normal. A significant reduction in bidirectional sodium flux was found in those patients with Crohn's disease and suggests that the intestinal mucosa is involved to a greater extent than can be judged by radiological appearances alone. This adds weight to the concept that Crohn's diseases is a diffuse rather than a focal lesion of the gastrointestinal tract.
mesh_terms: D003093:Colitis, Ulcerative / Q000378:metabolism / Q000601:surgery; D003424:Crohn Disease / Q000378:metabolism* / Q000601:surgery; D006801:Humans; D007081:Ileostomy; D007082:Ileum / Q000601:surgery; D007408:Intestinal Absorption; D007413:Intestinal Mucosa / Q000378:metabolism*; D011868:Radioisotopes; D012964:Sodium / Q000378:metabolism*; D012975:Sodium Isotopes
chemical_list: D011868:Radioisotopes; D012975:Sodium Isotopes; D012964:Sodium