The influence of chronic uremia on hepatic glycogen in the rat.
Long term maintenance of male Wistar rats following sub-total nephrectomy has been shown to alter carbohydrate metabolism. These rats frequently became hypoglycemic and concurrently demonstrated increased hepatic glycogen stores. Chemical analysis of glycogen revealed a significant increase in branching, with a concomitant decrease in glucose residues per segment. The influence of food intake and glycosuria are discussed. Decreased glycogen autolysis is attributed to increased glycogen branching in the uremic liver.
D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D002908:Chronic Disease; D006029:Glycosuria / Q000378:metabolism; D007003:Hypoglycemia / Q000209:etiology / Q000378:metabolism; D007668:Kidney / Q000502:physiology; D008099:Liver / Q000648:ultrastructure; D008112:Liver Glycogen / Q000378:metabolism*; D008297:Male; D008854:Microscopy, Electron; D009392:Nephrectomy; D051381:Rats; D013997:Time Factors; D014511:Uremia / Q000150:complications / Q000378:metabolism*
D001786:Blood Glucose; D008112:Liver Glycogen