Inhibition of dimethylhydrazine-induced neoplasia of the large intestine by disulfiram.
Disulfiram added to the diet of female CF1 mice inhibited large-bowel neoplasia produced by repeated subcutaneous administrations of dimethylhydrazine (DMH). The mice on a control diet all showed multiple tumors of the large bowel after DMH treatments, whereas there was no evidence of neoplasia in mice given disulfiram.
D000818:Animals; D004032:Diet; D004221:Disulfiram / Q000494:pharmacology*; D005260:Female; D006834:Hydrazines; D007414:Intestinal Neoplasms / Q000139:chemically induced / Q000517:prevention & control*; D051379:Mice; D009374:Neoplasms, Experimental / Q000139:chemically induced / Q000517:prevention & control
D006834:Hydrazines; D004221:Disulfiram