Renin-secreting clear cell carcinoma of the kidney.
A young woman with mild to moderate hypertension and normal PRA, serum potassium levels, and urinary aldosterone excretion rate was found to have a renal tumor by selective renal arteriogram. Renal vein renin activity indicated an increased production of renin from the kidney containing the tumor. At surgery, a clear cell carcinoma of the kidney was found that contained renin activity in excess of the surrounding kidney tissue. The renin activity appeared identical to human kidney renin. Previous renin-producing tumors have been associated with severe hypertension, elevated plasma renin activity, hypokalemia, and elevated urinary aldosterone excretion. This case should call attention to the renin-secreting tumor as a cause of even mild hypertension.
D000230:Adenocarcinoma / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000503:physiopathology / Q000601:surgery; D000328:Adult; D000450:Aldosterone / Q000378:metabolism; D003480:Cushing Syndrome / Q000175:diagnosis; D005260:Female; D006729:Hormones, Ectopic / Q000378:metabolism*; D006801:Humans; D006977:Hypertension, Renal / Q000175:diagnosis; D007668:Kidney / Q000503:physiopathology; D007680:Kidney Neoplasms / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000503:physiopathology / Q000601:surgery; D008854:Microscopy, Electron; D009392:Nephrectomy; D009384:Paraneoplastic Endocrine Syndromes / Q000175:diagnosis*; D011188:Potassium / Q000097:blood; D011859:Radiography; D012083:Renin / Q000097:blood / Q000378:metabolism*
D006729:Hormones, Ectopic; D000450:Aldosterone; D012083:Renin; D011188:Potassium