Continuous phrophylcatic anticonvulsants in selected childrens with febrile convulsions.
The recurrence rate of febrile convulsions is assessed in 108 children who had had either prolonged or repeated initial fits or had both a positive family history and persisting neurological disorder. Only 7 of 40 (17%) who received continuous prophylactic phenobarbitone or primidone for at minimum of 18 months had another fit compared with 40 of 68 (59%) children who were untreated (p less than 0.0005). Indications for continuous therapy are discussed.
D002648:Child; D002675:Child, Preschool; D002986:Clinical Trials as Topic; D005260:Female; D005334:Fever / Q000150:complications* / Q000188:drug therapy; D005500:Follow-Up Studies; D006801:Humans; D007223:Infant; D008297:Male; D010634:Phenobarbital / Q000627:therapeutic use*; D011324:Primidone / Q000627:therapeutic use*; D012008:Recurrence; D012640:Seizures / Q000188:drug therapy / Q000209:etiology / Q000517:prevention & control*
D011324:Primidone; D010634:Phenobarbital