title: Correlation of abnormal immunoglobulin with clinical features of myeloma.
abstract: Physical and chemical characteristics of the abnormal immunoglobulin as well as the immunoglobulin type are important determinants of the clinical features and prognosis in myeloma. A review of 270 cases of myeloma studied by the Acute Leukemia Group B showed that survival was adversely affected by azotemia. The presence of Bence Jones proteinuria adversely influenced survival even in patients who were not initially azotemic. The presence of lambda-type Bence Jones proteinuria resulted in greatly shortened survival in contrast to kappa-type Bence Jones proteinuria in the absence, or presence, of a serum IgG M-protein. The adverse effect of lambda-type Bence Jones protein could not be demonstrated in patients with IgA myeloma. Patients with IgA myeloma were found to have a noticeably shorter survival than those with IgG myeloma.
mesh_terms: D000373:Agglutinins / Q000032:analysis; D000477:Alkylating Agents / Q000627:therapeutic use; D001323:Autoantibodies / Q000032:analysis; D001536:Bence Jones Protein / Q000032:analysis*; D001809:Blood Viscosity; D001859:Bone Neoplasms / Q000150:complications / Q000188:drug therapy / Q000276:immunology* / Q000401:mortality; D003080:Cold Temperature; D006801:Humans; D006934:Hypercalcemia / Q000209:etiology; D007070:Immunoglobulin A / Q000032:analysis; D007072:Immunoglobulin D / Q000032:analysis; D007073:Immunoglobulin E / Q000032:analysis; D007075:Immunoglobulin M / Q000032:analysis; D007136:Immunoglobulins / Q000032:analysis*; D007952:Leukemia, Plasma Cell / Q000276:immunology; D009101:Multiple Myeloma / Q000150:complications / Q000188:drug therapy / Q000276:immunology* / Q000401:mortality; D009194:Myeloma Proteins / Q000032:analysis*; D014511:Uremia / Q000209:etiology
chemical_list: D000373:Agglutinins; D000477:Alkylating Agents; D001323:Autoantibodies; D007070:Immunoglobulin A; D007072:Immunoglobulin D; D007075:Immunoglobulin M; D007136:Immunoglobulins; D009194:Myeloma Proteins; D007073:Immunoglobulin E; D001536:Bence Jones Protein