Breeding nude (nu/nu) mice.
By using as sires homozygous nude males bearing thymus glands from their normal siblings, heterozygous females yield 50 per cent nu/nu offspring under conventional conditions.  Most nu/nu females are fertile, but in our experience only 20 per cent of them rear nude litters to weaning age.
D000818:Animals; D000831:Animals, Newborn; D001947:Breeding; D005260:Female; D005298:Fertility; D006579:Heterozygote; D006720:Homozygote; D007668:Kidney; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains / Q000502:physiology; D009154:Mutation; D011247:Pregnancy; D013950:Thymus Gland / Q000002:abnormalities* / Q000637:transplantation; D014184:Transplantation, Homologous