The excretion of 2-hydroxyestrone during the menstrual cycle.
A double isotope derivative determination technique was developed to investigate the excretion of 2-hydroxyestrone inhuman menstrual cycle. The method is highly specific, accurate and precise within the range of 0.2-20 nmol 2-hydroxyestrone/20ml of urine. The amounts of 2-hydroxyestrone excreted during menstrual cycle varied between 10 (proliferation phase) and 60 mug/24 h urine (ovulatory peak), which is comparable to that of estriol, supposed hitherto to be the main excretion product of estrogen metabolism.
D004970:Estrone / Q000031:analogs & derivatives* / Q000652:urine; D005260:Female; D006801:Humans; D006914:Hydroxysteroids / Q000652:urine; D007986:Luteinizing Hormone / Q000378:metabolism; D008598:Menstruation; D008722:Methods; D011276:Pregnanediol / Q000378:metabolism
D006914:Hydroxysteroids; D004970:Estrone; D007986:Luteinizing Hormone; D011276:Pregnanediol