Antibody suppression by cadmium.
Mice exposed to subclinical doses of cadmium chloride for ten weeks and inoculated with antigen six weeks after discontinuance of exposure had a remarkable decrease in antibody-forming cells, particularly IgG. These results indicate that immunosuppression produced by environmental contaminants may persist for several months after exposure to the contaminant.
D000818:Animals; D000917:Antibody Formation / Q000187:drug effects*; D000921:Antibody-Producing Cells / Q000187:drug effects; D000941:Antigens / Q000008:administration & dosage; D002104:Cadmium / Q000009:adverse effects* / Q000032:analysis; D006462:Hemolytic Plaque Technique; D007074:Immunoglobulin G; D007075:Immunoglobulin M; D007156:Immunologic Memory; D007668:Kidney / Q000032:analysis / Q000187:drug effects / Q000473:pathology; D008099:Liver / Q000032:analysis / Q000187:drug effects; D051379:Mice; D013154:Spleen / Q000187:drug effects; D013997:Time Factors
D000941:Antigens; D007074:Immunoglobulin G; D007075:Immunoglobulin M; D002104:Cadmium