Near-UV photoproduct(s) of L-typtophan: an inhibitor of medium-dependent repair of X-ray-induced single-strand breaks in DNA which also inhibits replication-gap closure in Escherichia coli DNA.
Near-UV photoproducts of L-tryptophan (TP), which are especially toxic for recombination-deficient (rec) mutants, were found to inhibit medium-dependent repair of X-ray-induced single-strand breaks. This inhibitor also slows the rate of closure of replication gaps, suggesting that these two processes may have a common pathway (or share a required step which TP can inhibit).
D002499:Centrifugation, Density Gradient; D004260:DNA Repair; D004261:DNA Replication; D004269:DNA, Bacterial / Q000032:analysis / Q000528:radiation effects*; D004926:Escherichia coli / Q000378:metabolism* / Q000528:radiation effects*; D011830:Radiation Effects; D014364:Tryptophan / Q000528:radiation effects*; D014466:Ultraviolet Rays
D004269:DNA, Bacterial; D014364:Tryptophan