Cardiovascular complications of pheochromocytoma crisis.
Two patients with hypertensive crises due to pheochromocytoma presented with unusual features suggestive of cardiovascular disorders other than pheochromocytoma. These features included transient cortical blindness and other neurologic deficits, electrocardiographic changes indicative of transmural infarction and peripheral arterial spasm. In both patients the diagnosis of pheochromocytoma was made later; removal of the tumor was followed by ready reversal of the clinical and biochemical abnormalities. Management of such cases includes suspicion of the diagnosis in the presence of atypical features, early initiation of therapy with alpha and beta adrenergic blocking agents and a definitive surgical procedure before peripheral vascular changes become irreversible. When an apparent myocardial infarction occurs, the diagnosis of coronary artery disease cannot always be excluded, but rapid stabilization of the clinical and electrocardiographic changes after adrenergic blockade would favor the diagnosis of a catecholamine-induced myocarditis. The coexistence of coronary artery disease and uncontrollable arrhythmias presents an increased risk but, if pheochromocytoma is suspected, surgery may be necessary despite the increased risk.
D000310:Adrenal Gland Neoplasms / Q000150:complications* / Q000175:diagnosis / Q000503:physiopathology; D000328:Adult; D001157:Arterial Occlusive Diseases / Q000000981:diagnostic imaging / Q000209:etiology*; D001766:Blindness / Q000209:etiology*; D003937:Diagnosis, Differential; D004562:Electrocardiography; D005260:Female; D006329:Heart Conduction System / Q000503:physiopathology*; D006801:Humans; D006973:Hypertension / Q000209:etiology*; D008875:Middle Aged; D009203:Myocardial Infarction / Q000175:diagnosis*; D009461:Neurologic Manifestations; D010673:Pheochromocytoma / Q000150:complications* / Q000175:diagnosis / Q000503:physiopathology; D011150:Popliteal Artery / Q000000981:diagnostic imaging; D011859:Radiography; D013035:Spasm / Q000000981:diagnostic imaging / Q000209:etiology*