Contractility of renal cortex following complete ureteral obstruction.
Contractility of strips of renal cortex obtained from rabbit kidneys obstructed by complete ureteral ligation for 8 and 32 days was tested and compared with control tissue.  Concentration-response data were obtained for norepinephrine, angiotensin, and 5-hydroxytrypamine, and were expressed as mg tension/cm of tissue.  Control tissue tested simultaneously revealed minimal responses, but obstructed tissue containing modified interstital cells revealed statistically significant evidence of contraction in response to all three drugs studied.  The response to norepinephrine could be blocked by the alpha adrenergic antagonist, phenoxybenzamine, but this drug did not significantly affect the response to angiotensin or 5-hydroxytryptamine.  The findings are related to similar observations reported in stimulated fibroblasts of granulation tissue and are discussed in terms of the possible role this phenomenon may play in the pathogenesis of renal interstitial injury.
D000804:Angiotensin II / Q000494:pharmacology; D000818:Animals; D066298:In Vitro Techniques; D007672:Kidney Cortex / Q000187:drug effects / Q000473:pathology / Q000503:physiopathology*; D008297:Male; D009638:Norepinephrine / Q000037:antagonists & inhibitors / Q000494:pharmacology; D010643:Phenoxybenzamine / Q000494:pharmacology; D011817:Rabbits; D012701:Serotonin / Q000494:pharmacology; D013268:Stimulation, Chemical; D014517:Ureteral Obstruction / Q000503:physiopathology* / Q000601:surgery
D010643:Phenoxybenzamine; D000804:Angiotensin II; D012701:Serotonin; D009638:Norepinephrine