Pituitary inhibitor of thyroxine.
A description is given of a new pituitary function. It is suggested that the new function acts to decrease gradually the responsiveness of the peripheral tissues to thyroid hormones throughout life. It is suggested that the postulated relative hypothyroidism of older animals might contribute to their loss of viability.
D000375:Aging; D000818:Animals; D002417:Cattle; D006706:Homeostasis; D007037:Hypothyroidism / Q000209:etiology; D008954:Models, Biological; D010101:Oxygen Consumption / Q000187:drug effects; D010902:Pituitary Gland / Q000502:physiology; D051381:Rats; D013974:Thyroxine / Q000037:antagonists & inhibitors*; D014020:Tissue Extracts / Q000494:pharmacology*
D014020:Tissue Extracts; D013974:Thyroxine