Treatment of ethylene glycol toxicosis in cats.
Ethylene glycol (EG) was orally administered to 27 cats at dose levels of 4, 6, or 8 ml/kg of body weight. Treatment was initiated 4 or 8 hours later and consisted of giving (intraperitoneal injection, IP) 5 ml of 20% ethanol in isotonic saline solution and 6 ml of 5% sodium bicarbonate in isotonic saline solution per kilogram of body weight. Treatment was repeated every 6 or 8 hours for approximately 56 hours after initial treatment was given. The 6 control cats (i.e., untreated) and all cats treated 8 hours after EG was given in doses of 6 ml/kg (4 cats) or 8 ml/kg (4 cats) died. Only 1 of 4 cats (25%) recovered in the group given EG at the dose level of 4 ml/kg of body weight and initial treatment started 8 hours later. Two of 3 cats (67%) recovered in each of the groups given EG at the dose levels of 4 ml/kg and 6 ml/kg and initially treated 4 hours after dosing, but only 1 of 3 cats (33%) recovered in the group given 8 ml of eg/kg and first treated 4 hours later. Limitations of successful treatment are high doses of EG and delays in initiating the treatment.
D000818:Animals; D001639:Bicarbonates / Q000008:administration & dosage / Q000627:therapeutic use; D002371:Cat Diseases / Q000139:chemically induced / Q000188:drug therapy* / Q000473:pathology; D002415:Cats; D000431:Ethanol / Q000008:administration & dosage / Q000627:therapeutic use; D005026:Ethylene Glycols / Q000633:toxicity*; D005260:Female; D007274:Injections, Intraperitoneal; D007668:Kidney / Q000473:pathology; D008297:Male; D009069:Movement Disorders / Q000662:veterinary; D012640:Seizures / Q000662:veterinary
D001639:Bicarbonates; D005026:Ethylene Glycols; D000431:Ethanol