Antimalarial amino alcohols II: anthraceneaminoethanols and anthraceneaminopropanols (1- and 9-substituted).
The syntheses of seven anthracene amino alcohols with one, two, or three additional substituents are described. These compounds include three 1-aminoethanols, two 9-aminoethanols, and two 9-aminopropanols, prepared from substituted anthraquinones or from 10-chloro-9-anthraldehydes. The antimalarial activity of these compounds, as well as tentative structure-activity relationships, is discussed in the light of previously published work.
D000605:Amino Alcohols / Q000138:chemical synthesis / Q000627:therapeutic use; D000818:Animals; D000873:Anthracenes / Q000138:chemical synthesis / Q000627:therapeutic use; D000962:Antimalarials / Q000138:chemical synthesis / Q000627:therapeutic use; D008288:Malaria / Q000188:drug therapy; D051379:Mice; D010962:Plasmodium berghei; D013329:Structure-Activity Relationship
D000605:Amino Alcohols; D000873:Anthracenes; D000962:Antimalarials