Modification by imidazoles of ocular inflammatory and pressure responses.
Imidazole, given intraperitoneally to rabbits, inhibited the prostaglandin E1-induced (PGE1) elevation of intraocular pressure. The maximum imidaz-le effect occurred at three to six hours after intraperitoneal infection. The prostaglandin E1-induced aqueous humor protein elevation was reduced markedly in the imidazole-pretreated rabbits. Intravenous administration of imidazole also was effective in reducing the intraocular pressure elevation produced by prostaglandin E1. Imidazole pretreatment by subconjunctival, subdermal, or topical routes had no such effect. Imidazole derivatives, 1-methylimidazole and 2-methylimidazole, given intraperitoneally, blocked the effect of PGE1 on intraocular pressure and aqueous humor protein. Imidazole pretreatment also inhibited the elevation of intraocular pressure produced by topical nitrogen mustard, 1 per cent.
D000287:Administration, Topical; D000818:Animals; D000893:Anti-Inflammatory Agents; D001082:Aqueous Humor / Q000187:drug effects; D001205:Ascorbic Acid / Q000378:metabolism; D003228:Conjunctiva; D003315:Cornea; D007093:Imidazoles / Q000008:administration & dosage / Q000494:pharmacology*; D007249:Inflammation; D007267:Injections; D007274:Injections, Intraperitoneal; D007275:Injections, Intravenous; D007279:Injections, Subcutaneous; D007429:Intraocular Pressure / Q000187:drug effects*; D009588:Nitrogen Mustard Compounds / Q000008:administration & dosage / Q000494:pharmacology; D011458:Prostaglandins E / Q000008:administration & dosage / Q000037:antagonists & inhibitors / Q000494:pharmacology; D011506:Proteins / Q000378:metabolism; D011817:Rabbits; D013997:Time Factors
D000893:Anti-Inflammatory Agents; D007093:Imidazoles; D009588:Nitrogen Mustard Compounds; D011458:Prostaglandins E; D011506:Proteins; D001205:Ascorbic Acid