Tumor-induced angiogenesis: lack of inhibition by irradiation.
The effect of irradiation of tumors on their ability to induce vascular responses (angiogenesis) was studied. Rat Walker carcino-sarcoma 256, rabbit V2 carcinoma, mouse (C57B1) melanoma and mouse (129) teratoma (OTT 6050, 100K) were irradiated with up to 5000R, then grafted either to the chicken chorioallantoic membrane or intracorneally into adult rabbits to assess competence to provoke angiogenesis. For all tumors and both assay systems the results were similar: irradiation did not interfere with tumor-induced vascular responses.
D043925:Angiogenesis Inducing Agents / Q000528:radiation effects*; D000818:Animals; D001808:Blood Vessels / Q000528:radiation effects*; D002277:Carcinoma / Q000532:radiotherapy*; D002279:Carcinoma 256, Walker / Q000532:radiotherapy*; D002460:Cell Line; D002470:Cell Survival / Q000528:radiation effects; D002642:Chick Embryo; D003315:Cornea; D005134:Eye Neoplasms / Q000532:radiotherapy*; D006133:Growth Substances / Q000528:radiation effects*; D008545:Melanoma / Q000532:radiotherapy*; D051379:Mice; D008810:Mice, Inbred C57BL; D008811:Mice, Inbred DBA; D009368:Neoplasm Transplantation; D009374:Neoplasms, Experimental; D011817:Rabbits; D011829:Radiation Dosage; D011830:Radiation Effects; D013724:Teratoma / Q000532:radiotherapy*; D014183:Transplantation, Heterologous; D014184:Transplantation, Homologous; D014655:Vascular Resistance / Q000528:radiation effects
D043925:Angiogenesis Inducing Agents; D006133:Growth Substances