title: [Synergism of colistin and sulfonamide in proteus species (author's transl)].
abstract: In agar diffusion testing of Proteus mirabilis strains sensitive to sulfonamide a synergistic effect of colistine (C) and sulfonamide (S) was demonstrated. By quantitative evaluation these results were confirmed in 100 strains of Proteus mirabilis and 100 strains of indol-positive Proteus spp. using broth dilution method. Combining 1 part C with 10 parts S the mean increase in sulfonamide sensitivity was enhanced fourfold. Increasing the inoculum sensitivity of Proteus against the combination of C and S was still found to range within therapeutic blood levels. Therefore in treatment of Proteus infection the positive synergistic effect of C+S should be taken into consideration.
mesh_terms: D003091:Colistin / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D004357:Drug Synergism; D008826:Microbial Sensitivity Tests; D011511:Proteus / Q000187:drug effects*; D011513:Proteus mirabilis / Q000187:drug effects; D011514:Proteus vulgaris / Q000187:drug effects; D013411:Sulfadiazine / Q000494:pharmacology; D013416:Sulfamerazine / Q000494:pharmacology; D013432:Sulfathiazoles / Q000494:pharmacology; D013449:Sulfonamides / Q000494:pharmacology*
chemical_list: D013432:Sulfathiazoles; D013449:Sulfonamides; D013411:Sulfadiazine; D013416:Sulfamerazine; D003091:Colistin
vernacular_title: Untersuchungen zum Synergismus von Colistin und Sulfonamid bei Proteus spec