Translocation 4p-- syndrome: a general review.
The casee presented here may be the first fully identified and verified cas of translocation 4p-- syndrome, a B4/G22 translocation, ie, 45,XX,-4,-22,+t(4q 22q). Thirty-nine other cases of the 4p--syndrome, including one other possible translocation case, have been found in the medical literature. Conventional chromosome studies cannot distinguish between 4p-- (Wolf) syndrome and 5p-- (cri-du-chat) syndrome, and the clinical features, as in our case, may not be sufficiently characteristic to permit differentiation. The newer chromosome banding techniques have made specific identification possible.
D000015:Abnormalities, Multiple; D002675:Child, Preschool; D002869:Chromosome Aberrations / Q000175:diagnosis; D025063:Chromosome Disorders; D002905:Chromosomes, Human, 4-5; D003410:Cri-du-Chat Syndrome / Q000175:diagnosis; D003878:Dermatoglyphics; D003937:Diagnosis, Differential; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007621:Karyotyping / Q000379:methods; D013577:Syndrome; D014178:Translocation, Genetic