title: Pentaerythritol tetranitrate and metabolites in rat plasma.
abstract: Intact pentaerythritol (PE) tetranitrate and all seven of its metabolites were present in blood withdrawn from the hearts of rats dosed by gavage with 14-C-PE tetranitrate (10 mg/kg). The plasma half-life (T 1/2) of PE tetranitrate was 2 hours which is far longer than the rat T 1/2 values of all other organic nitrates in clinical use. PE trinitrate, the obligatory metabolite of PE tetranitrate now in clinical trial, establishes much higher plasma levels and has a longer T 1/2 (3 hours) than its parent drug. PE trinitrate glucuronide acts as a reservoir for its aglycone and remains in blood for 48 hours after PE tetranitrate administration.
mesh_terms: D000818:Animals; D002250:Carbon Radioisotopes; D002855:Chromatography, Thin Layer; D005965:Glucuronates / Q000097:blood; D006207:Half-Life; D007700:Kinetics; D008297:Male; D010417:Pentaerythritol Tetranitrate / Q000097:blood*; D051381:Rats
chemical_list: D002250:Carbon Radioisotopes; D005965:Glucuronates; D010417:Pentaerythritol Tetranitrate