Cardiopulmonary bypass. Microembolization and platelet aggregation.
Particulate microemboli and in vitro platelet aggregation were studied in blood of patients during cardiac operations with an electronic particle size analyzer. A small gradient of microemboli developed on passage of blood through a bubble oxygenator but not through a membrane oxygenator. However, with both types of oxygenators, there was a sustained increase in the volume of microemboli in cardiotomy return blood which was much greater than in aterial blood. After cardiopulmonary bypass with both oxygenators, there was a comparable reduction in the volume of circulating platelets which exceeded that of the hemoglobin concentration, indicating platelet loss exceeded that that expected from hemodilution alone. However, the total volume and mean size of platelet aggregates induced in blood of patients after membrane oxygenation was significantly greater than similar measurements after bubble  oxygenation. This study shows that membrane oxygenation reduces particulate microembolization and preserves platelet function in patients undergoing cardiac operations when compared to bubble oxygenation.
D000244:Adenosine Diphosphate / Q000097:blood; D000818:Animals; D001810:Blood Volume; D002315:Cardiopulmonary Bypass / Q000009:adverse effects*; D004285:Dogs; D004617:Embolism / Q000209:etiology*; D004618:Embolism, Air / Q000209:etiology; D005112:Extracorporeal Circulation / Q000009:adverse effects*; D005374:Filtration; D006461:Hemolysis; D006801:Humans; D066298:In Vitro Techniques; D010106:Oxygenators; D010107:Oxygenators, Membrane; D010316:Particle Size; D010973:Platelet Adhesiveness; D010974:Platelet Aggregation; D013921:Thrombocytopenia / Q000209:etiology
D000244:Adenosine Diphosphate