Effect of ventricular aberrancy on fibrillation threshold.
VFT's were determined in 12 open-chest dogs at epicardial sites in the right and left ventricles (RV and LV) following normally or aberrantly conducted beats.  The normal beats were produced by right atrial pacing, and the aberrant beats by surgical RBBB or ventricular pacing at an RV or LV site.  The mean VFT following normal beats was 21.2 plus or minus 1.8 ma. in RV and 23.0 plus or minus 2.7 ma. in LV. The mean VFT following aberrant beats of RBBB was 21.3 plus or minus 2.6 ma. in RV and 25.0 plus or minus 2.8 ma. in LV.  The difference between the mean VFT of normal beats and that of aberrant beats was not statistically significant.  The mean values of VFT's determined in RV or LV following aberrant beats produced by pacing of the contralateral ventricle were not significantly different from those of the normal beats.  The mean VFT was 22.9 plus or minus 3.1 ma. in RV and 20.1 plus or minus 2.1 ma. in LV.  These results indicate that  the aberrancy of ventricular beats per se is not associated with decreased VFT or increased ventricular vulnerability to fibrillation.  The most predictable observation was that the mean VFT's were significantly lower in both ventricles when they were determined at the site of application of pacing stimuli.  The mean values were 12.4 plus or minus 1.2 ma. in RV and 13.6 plus or minus 1.6 ma. in LV.  This decrease in VFT may be due to slow conduction and increased asynchrony of recovery of excitability at or near the site of application of pacing stimuli.
D000818:Animals; D002037:Bundle-Branch Block / Q000150:complications* / Q000503:physiopathology; D004285:Dogs; D004562:Electrocardiography; D006329:Heart Conduction System / Q000503:physiopathology*; D006352:Heart Ventricles / Q000503:physiopathology*; D010138:Pacemaker, Artificial; D014693:Ventricular Fibrillation / Q000209:etiology* / Q000503:physiopathology