Newborn blood levels of lidocaine and mepivacaine in the first postnatal day following maternal epidural anesthesia.
Distribution and elimination of lidocaine and mepivacaine were studies in 114 subjects after obstetric epidural anesthesia, Epinephrine significantly lowered the concentrations of lidocaine in the mothers' circulations by about 33 per cent, and the concentrations of mepivacaine by about 22 per cent. It also significantly altered their concentrations in the newborns' circulations at delivery and in the first 4 hours after birth. More mepivacaine than lidocaine crossed the placenta. The mepivacaine concentration in the cord blood was 36 to 47 per cent higher, and the mean fetal to maternal ratio for mepivacaine without epinephrine was 0.64, in contrast to 0.52 for the equivalent lidocaine group. Of importance was the long persistance of either drug in the newborns' circulation. Detectable levels of lidocaine and mepivacaine were present until 8 and 24 hours after birth, respectively. Pharmacokinetic models revealed that the long-term rate of disappearance of lidocaine was approximately three times as fast as that of mepivacaine. Computed half-times averaged 3 hours for lidocaine and 9 hours for mepivacaine.
D000328:Adult; D000763:Anesthesia, Caudal; D000767:Anesthesia, Epidural; D000773:Anesthesia, Obstetrical; D004837:Epinephrine / Q000494:pharmacology; D005260:Female; D005312:Fetal Blood; D006801:Humans; D007231:Infant, Newborn; D008012:Lidocaine / Q000008:administration & dosage / Q000097:blood*; D008297:Male; D008431:Maternal-Fetal Exchange; D008619:Mepivacaine / Q000008:administration & dosage / Q000097:blood*; D008657:Metabolic Clearance Rate; D011247:Pregnancy; D013997:Time Factors
D008012:Lidocaine; D008619:Mepivacaine; D004837:Epinephrine