title: Pharmacokinetics of sulbenicillin, a new broad-spectrum semisynthetic penicillin.
abstract: In a pharmacolinetic study on a new semisynthetic penicillin, alpha-sulfobenzylpenicillin, sulbenicillin, serum level, serum half-life, apparent distribution volume, renal clearance, urinary excretion, and metabolism were determined after a 4-gm intravenous dose and compared to that of carbenicillin in 5 patients with normal renal function. In the case of sulbenicillin, the mean serum concentration at 1 hr was 157 plus or minus 25 mug/ml, the mean serum half-life was 70 plus or minus 10 min, the renal clearance was 95 plus or minus 25 ml/min, and the total urinary recovery after 24 hr was about 80% of the dose. The only metabolite detected in the urine was the penicilloic acid derivative, in an amount usually less than 5% of the dose. Serum values, serum half-live, renal clearances, and excretion pattern did not differ significantly from that of carbenicillin. In 8 patients with decreased renal function (creatinine clearance less than 50 ml/min) there was an inverse correlation between creatinine clearance and serum half-life.
mesh_terms: D000328:Adult; D000368:Aged; D001681:Biological Assay; D002228:Carbenicillin / Q000097:blood / Q000652:urine; D002855:Chromatography, Thin Layer; D003404:Creatinine / Q000652:urine; D005260:Female; D006207:Half-Life; D006801:Humans; D007668:Kidney / Q000502:physiology / Q000503:physiopathology; D007700:Kinetics; D008297:Male; D008875:Middle Aged; D010400:Penicillin G / Q000031:analogs & derivatives* / Q000097:blood / Q000652:urine; D011485:Protein Binding; D011549:Pseudomonas; D012709:Serum Albumin / Q000378:metabolism; D013451:Sulfonic Acids / Q000097:blood / Q000652:urine
chemical_list: D012709:Serum Albumin; D013451:Sulfonic Acids; D003404:Creatinine; D002228:Carbenicillin; D010400:Penicillin G