title: The nitrofurans as sperm immobilizing agents.
abstract: In certain critical concentrations nitrofurantoin sodium and nitrofurazone cause sperm immobilization. Intraoperative was irrigation with these solutions in 16 patients produced sterility in the immediate postoperative period. This procedure minimizes time-consuming postoperative sperm analyses. Moreover, in underdeveloped countries where postoperative followup is difficult to obtain, this procedure would provide an additional positive factor in an attempt to ensure sterility.
mesh_terms: D000818:Animals; D003864:Depression, Chemical; D006168:Guinea Pigs; D006801:Humans; D008297:Male; D009581:Nitrofurans / Q000494:pharmacology* / Q000633:toxicity; D009582:Nitrofurantoin / Q000494:pharmacology; D009583:Nitrofurazone / Q000494:pharmacology; D013078:Sperm Immobilizing Agents / Q000494:pharmacology* / Q000633:toxicity; D013094:Spermatozoa / Q000187:drug effects*; D014649:Vas Deferens / Q000187:drug effects; D014659:Vasectomy
chemical_list: D009581:Nitrofurans; D013078:Sperm Immobilizing Agents; D009582:Nitrofurantoin; D009583:Nitrofurazone