title: Low platelet adhesiveness and other hemostatic abnormalities in hypothyroidism.
abstract: Fifteen patients with definite hypothyroidism and two with probable hypothyroidism had extensive hemostatic profiles done. In 12 of the 16 patients tested, the platelet adhesiveness (platelet retention in a glass bead column) was abnormal, and in 1 more it was borderline. In the six patients who were studied repeatedly, hemostatic abnormalities either markedly improved or disappeared after treatment with L-thyroxine. It is concluded that, in addition to the previously reported coagulation factor deficiencies (which we also observed in some of our patients), low platelet adhesiveness occurs frequently in patients with hypothyroidism.
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D001779:Blood Coagulation Factors / Q000032:analysis; D001780:Blood Coagulation Tests; D004837:Epinephrine / Q000008:administration & dosage / Q000494:pharmacology; D005260:Female; D006487:Hemostasis; D006801:Humans; D007037:Hypothyroidism / Q000097:blood* / Q000150:complications / Q000188:drug therapy; D008297:Male; D008875:Middle Aged; D010973:Platelet Adhesiveness; D010974:Platelet Aggregation / Q000187:drug effects; D013974:Thyroxine / Q000494:pharmacology / Q000627:therapeutic use*
chemical_list: D001779:Blood Coagulation Factors; D013974:Thyroxine; D004837:Epinephrine