Percutaneous penetration and disposition of triclocarban in man: body showering.
The percutaneous penetration and metabolic disposition of 14C-3-4,4'-trichlorocarbanilide (triclocarban, TCC) after body showering has been determined in man. Single intravenous doses of trace amounts 14C-triclocarban were given to subjects to determine the pharmacologic disposition of the compound before conducting the shower study. Radioactivity was rapidly cleared from blood after intravenous administrations of 14C-triclocarban in propylene glycol with a blood clearance half-life of 8.6 hours. About 54% of the dose was excreted in the feces and 21% of the dose in the urine with a urinary elimination half-life of ten hours. No radioactivity was detected in the saliva. Subjects took a single shower employing a whole body lather with approximately 7 gm of soap containing 2% 14C-triclocarban on a soap basis. Special blood withdrawal and urinary/fecal collection techniques were utilized that minimized contamination of samples by extraneous 14C-triclocarban. About 0.23% of the applied radioactive dose was recovered in the feces after six days and 0.16% of the dose in the urine after two days. At all sampling times blood levels of radioactivity were below the detection limit of the method (10 part per billion).
D000890:Anti-Infective Agents / Q000097:blood; D000891:Anti-Infective Agents, Local / Q000378:metabolism*; D001494:Baths; D002224:Carbanilides / Q000097:blood / Q000378:metabolism*; D002250:Carbon Radioisotopes; D055598:Chemical Phenomena; D002621:Chemistry; D002713:Chlorine / Q000378:metabolism; D005243:Feces / Q000032:analysis; D006207:Half-Life; D006801:Humans; D007275:Injections, Intravenous; D008297:Male; D012869:Skin Absorption; D012915:Soaps; D013997:Time Factors
D000890:Anti-Infective Agents; D000891:Anti-Infective Agents, Local; D002224:Carbanilides; D002250:Carbon Radioisotopes; D012915:Soaps; D002713:Chlorine