title: The pathogenesis of single experimental infections with Strongylus vulgaris in foals.
abstract: The clinical signs, pathology and clinical pathology associated with single experimental infections of Strongylus vulgaris in worm-free pony foals are described. The major clinical signs which became apparent in the infected foals during the first three weeks were pyrexia, anorexia, dullness and abdominal pain. Within the first two weeks of infection lesions were confined to the intestine and terminal branches of the intestinal arteries and consisted of mucosal, submucosal and serosal haemorrhage together with arteritis of submucosal and serosal arteries and also a marked inflammatory reaction. The main lesion seen three weeks after infection was gross thrombosis of the anterior mesenteric artery or one of its major branches. On section these affected arteries showed marked intimal thickening with infiltration of plasma cells, lymphocytes, macrophages and neutrophils. Between one and four months after infection the gross lesions were predominantly in the arteries and consisted of fibrous thickening of the arterial wall and thrombosis associated with the presence of developing fourth stage larvae. Four months after infection the arterial lesions were still prominent and microscopically there was fibrosis of the wall of the affected artery with wide-spread disruption of the intima. In the adventitia organised thrombi were apparent in the vasa vasorum and resulted in the obliteration of their lumina. The typical lesion associated with the return of fifth stage larvae to the intestine was nodule formation in close proximity to thrombosed terminal intestinal arteries and sections of parasites were seen in the intestinal wall surrounded by neutrophils and necrotic debris. By nine months after infection the arterial lesion had healed, but histologically there was fibrosis of the intima and macrophages containing haemosiderin were seen in the arterial wall. The most significant haematological findings during the experimental period were a marked polymorphonuclear leucocytosis and an increase in the number of circulating eosinophils in the infected animals. Also marked was an increase in the serum globulin levels of the infected foals.
mesh_terms: D000818:Animals; D001158:Arteries / Q000473:pathology; D001167:Arteritis / Q000662:veterinary; D001798:Blood Proteins / Q000032:analysis; D001831:Body Temperature; D002432:Cecum / Q000473:pathology; D004906:Erythrocyte Count; D006400:Hematocrit; D006454:Hemoglobins; D006736:Horses; D007082:Ileum / Q000473:pathology; D007422:Intestines / Q000098:blood supply; D007958:Leukocyte Count; D008638:Mesenteric Arteries / Q000473:pathology; D008641:Mesenteric Vascular Occlusion / Q000662:veterinary; D012007:Rectum; D013319:Strongyle Infections, Equine / Q000097:blood / Q000473:pathology*; D013927:Thrombosis / Q000662:veterinary
chemical_list: D001798:Blood Proteins; D006454:Hemoglobins