A familial F/G translocation [t(p-; 22q+)] observed in three generations.
A family is described in which a translocation between chromosomes 20 and 22 has been observed in three generations. Two first cousins with remarkably similar malformations and mental retardation have identical karyotypes which, after chromosome banding, were interpreted as partially trisomic for the short arm of chromosome No. 20.
D000015:Abnormalities, Multiple / Q000235:genetics*; D000328:Adult; D002648:Child; D002675:Child, Preschool; D002869:Chromosome Aberrations; D002904:Chromosomes, Human, 21-22 and Y; D005145:Face / Q000002:abnormalities; D005260:Female; D006228:Hand Deformities, Congenital; D006801:Humans; D007223:Infant; D008607:Intellectual Disability / Q000235:genetics*; D007621:Karyotyping; D008297:Male; D010375:Pedigree; D014178:Translocation, Genetic