Hyperplastic and neoplastic lesions of the kidney in Buffalo rats of varying ages ingesting N-4-(4'-flurobiphenyl)acetamide.
Inbred Buffalo male and female rats 4, 12, 24, and 52 weeks of age ingested 0.04% N-4(4'-fluorobiphenyl)acetamide in a semisynthetic diet for 36 weeks. Animals were killed 12 weeks later. Male rats 24 weeks old were more susceptible to the development of carcinomas of the kidney than were female rats of the same age or younger or older animals of both sexes. Rats with renal cell carcinomas either did not have hepatic carcinomas or had small ones.
D000081:Acetamides / Q000633:toxicity*; D000230:Adenocarcinoma / Q000139:chemically induced*; D000284:Administration, Oral; D000367:Age Factors; D000818:Animals; D001713:Biphenyl Compounds / Q000633:toxicity*; D002273:Carcinogens; D004032:Diet; D005260:Female; D006845:Hydrocarbons, Fluorinated / Q000633:toxicity; D007680:Kidney Neoplasms / Q000139:chemically induced*; D008113:Liver Neoplasms / Q000139:chemically induced; D008297:Male; D009368:Neoplasm Transplantation; D009374:Neoplasms, Experimental / Q000139:chemically induced; D011230:Precancerous Conditions / Q000139:chemically induced*; D051381:Rats; D011915:Rats, Inbred BUF; D012737:Sex Factors
D000081:Acetamides; D001713:Biphenyl Compounds; D002273:Carcinogens; D006845:Hydrocarbons, Fluorinated