title: The evolution of selectively similar electrophoretically detectable alleles in finite natural populations.
abstract: Most of the models of population genetics are not realistic when applied to data on electrophoretic variants of proteins because the same net charge may result from any of several amino acid combinations. In the absence of realistic models they have, however, been widely used to test competing hypotheses about the origin and maintenance of genetic variation in populations. In this paper I present a general method for determining probability generating functions for electrophoretic state differences. Then I use the method to find allelic state difference distributions for selectively similar electrophoretically detectable alleles in finite natural populations. Predicted patterns of genetic variation, both within and among species, are in reasonable accord with those found in the Drosophila willistoni group by Ayala et al. (1972) and by Ayala and Tracey (1974).
mesh_terms: D000483:Alleles; D000596:Amino Acids; D000818:Animals; D004330:Drosophila; D004586:Electrophoresis; D014644:Genetic Variation; D005828:Genetics, Population; D008954:Models, Biological; D011336:Probability; D012641:Selection, Genetic
chemical_list: D000596:Amino Acids