Cushing's syndrome and pituitary-adrenal suppression due to clobetasol propionate.
Widespread application of clobetasol propionate resulted in suppression of the hypothalamic pituitary axis in four patients. Three patients showed Cushigoid features and developed symptoms of adrenocortical insufficiency on withdrawal of clobetasol.
D001623:Betamethasone / Q000009:adverse effects / Q000031:analogs & derivatives* / Q000627:therapeutic use; D003366:Cosyntropin; D003480:Cushing Syndrome; D005260:Female; D006801:Humans; D007328:Insulin; D008297:Male; D008875:Middle Aged; D010912:Pituitary-Adrenal Function Tests; D010913:Pituitary-Adrenal System / Q000187:drug effects*; D011565:Psoriasis / Q000175:diagnosis
D007328:Insulin; D003366:Cosyntropin; D001623:Betamethasone