[Inhibition of pentagastrin-induced gastric-acid secretion by somatostatin in man (author's transl)].
The effect of somatostatin on pentagastrin-induced gastric-acid secretion was measured in three healthy volunteers and four patients with duodenal ulcer. Somatostatin (100, 200 and 400 mug/h) inhibited secretory volume and acid concentration simulated by pentagastrin infusion (2 mug/kg - h), the effect being dose-dependent. In the patients with duodenal ulcer somatostatin given as a bolus (50 mug) and by subsequent infusion (150 mug/h) reduced maximal acid output after subcutaneous injection of 2.0 mug/kg pentagastrin by 68-96%.
D000293:Adolescent; D000328:Adult; D000368:Aged; D004381:Duodenal Ulcer / Q000503:physiopathology; D005745:Gastric Acidity Determination; D005750:Gastric Juice / Q000187:drug effects* / Q000378:metabolism; D006801:Humans; D007279:Injections, Subcutaneous; D008297:Male; D008875:Middle Aged; D010418:Pentagastrin / Q000008:administration & dosage / Q000037:antagonists & inhibitors; D013004:Somatostatin / Q000494:pharmacology*
D013004:Somatostatin; D010418:Pentagastrin
Hemmung der pentagastrin-induzierten Säuresekretion des Magens beim Menschen durch Somatostatin