[ Change in the protein spectrum of the erythrocytic membranes in certain anemias].
Proteins of human erythrocyte membranes were studied in normal state and in different anaemias. After solubilization of cell "shadows" in phenol-urea-acetic acid-water system in membranes there were found, by means of polyacrylamide gel disc electrophoresis, 20 protein fractions with molecular weight from 48000 to 225000; seven of them glycoproteins. In 9 cases out of 36 a complete or partial disappearance of a glycoprotein component with molecular weight of 170000 was observed in erythrocyte membranes from patients with inherited spherocytosis and Markiafava--Mikely disease.
D000740:Anemia / Q000097:blood*; D000744:Anemia, Hemolytic, Autoimmune / Q000097:blood; D000756:Anemia, Sideroblastic / Q000097:blood; D001797:Blood Protein Electrophoresis; D001798:Blood Proteins / Q000032:analysis*; D002462:Cell Membrane / Q000032:analysis; D004591:Electrophoresis, Polyacrylamide Gel; D004912:Erythrocytes / Q000032:analysis*; D006023:Glycoproteins / Q000097:blood; D006457:Hemoglobinuria, Paroxysmal / Q000097:blood; D006801:Humans; D006932:Hyperbilirubinemia / Q000097:blood; D008970:Molecular Weight; D011087:Polycythemia Vera / Q000097:blood
D001798:Blood Proteins; D006023:Glycoproteins
Izmenenie belkovogo spektra membran éritrotsitov pri nekotorykh anemiiakh