Brain tissue levels in a fatal case of neonatal mepivacaine (Carbocaine) poisoning.
A fatal case of mepivacaine poisoning in a newborn infant is reported. Regional brain tissue concentrations of mepivacaine were determined by a sensitive and specific gas chromatographic-mass spectrometric method. The brain tissue levels in this patient were higher than those previously reported, possibly due to alkalosis occurring several hours prior to the infant's death.
D000328:Adult; D000773:Anesthesia, Obstetrical / Q000009:adverse effects; D001923:Brain Chemistry; D002531:Cerebellum / Q000032:analysis; D002540:Cerebral Cortex / Q000032:analysis; D002584:Cervix Uteri; D002849:Chromatography, Gas; D005078:Exchange Transfusion, Whole Blood; D005260:Female; D005318:Fetal Heart; D006339:Heart Rate; D006801:Humans; D007231:Infant, Newborn; D007232:Infant, Newborn, Diseases / Q000139:chemically induced*; D007668:Kidney / Q000032:analysis; D008099:Liver / Q000032:analysis; D013058:Mass Spectrometry; D008526:Medulla Oblongata / Q000032:analysis; D008619:Mepivacaine / Q000032:analysis / Q000097:blood / Q000506:poisoning*; D009407:Nerve Block / Q000009:adverse effects; D011149:Pons / Q000032:analysis; D011247:Pregnancy; D013116:Spinal Cord / Q000032:analysis
D008619:Mepivacaine