title: Differential effects of hypothalamic deafferentation upon luteinizing hormone-releasing hormone in the median eminence and organum vasculosum of the lamina terminalis.
abstract: Complete deafferentation of the medial basal hypothalamus (MBH) was performed in male rats to ascertain the location of the cell bodies of nerve terminals containing luteinizing hormone-releasing hormone (LH-RH) in the external layer of the median eminence and the organum vasculosum of the lamina terminalis (OVLT). Radioimmunoassayable LH-RH in the MBH decreased to one-fourth of the control value 10 days after complete deafferentation, whereas, no change was observed in an area coextensive with the OVLT. Immunohistochemical staining of LH-RH appeared less intense within the median eminence of deafferented animals but was normal in the OVLT. These results suggest that the cell bodies of neurons producing LH-RH found in terminals in the OVLT lie outside the MBH. The possible explanations for the decreased LH-RH content in the median eminence are discussed.
mesh_terms: D000818:Animals; D003714:Denervation; D007987:Gonadotropin-Releasing Hormone / Q000378:metabolism*; D007031:Hypothalamus / Q000378:metabolism* / Q000502:physiology; D008297:Male; D008473:Median Eminence / Q000378:metabolism; D009411:Nerve Endings / Q000378:metabolism*; D009474:Neurons / Q000502:physiology*; D009475:Neurons, Afferent / Q000502:physiology*; D051381:Rats
chemical_list: D007987:Gonadotropin-Releasing Hormone