Correlation between the carcinogenicities of nitrofuran derivatives and their destructive actions on sebaceous glands of mouse skin.
The effects of six nitrofuran derivatives (including a formerly used food preservative) on mouse skin sebaceous glands were investigated. A close correlation was found between the carcinogenicities and destructive activities of nitrofuran derivatives on the sebaceous glands. 5-Nitro-2-furaldehyde semicarbazone and 4-methyl-1-[(5-nitrofurfurylidene)amino]-2-imidazolidinone, which are carcinogenic, caused marked destruction of the glands at a dose of 1-5 mg/mouse. 2-(5-Nitro-2-furfurylidene)-aminoethanol almost completely destroyed the glands at a dose of 5 mg/mouse; its carcinogenicity has not yet been investigated. 1-[(5-Nitrofurfurylidene)amino]-carcinogenic, did not affect the glands, even at a dose of 5 mg/mouse. 2-(2-Furyl)-3-(5-nitro-2-furyl)acrylamide, which is a potent mutagen but not carcinogenic, had no effect on the glands at a dose of 5 mg/mouse. Under similar conditions, the potent carcinogen 7,12-dimethylbenz(alpha)athracene almost completely destroyed the sebaceous glands at a dose of 0.05 mg/mouse, but dimethyl sulfoxide (used as solvent for the test compounds) had no effect.
D000818:Animals; D001551:Benz(a)Anthracenes / Q000494:pharmacology; D002273:Carcinogens / Q000633:toxicity; D004121:Dimethyl Sulfoxide / Q000494:pharmacology; D005260:Female; D007093:Imidazoles; D051379:Mice; D008813:Mice, Inbred ICR; D009153:Mutagens / Q000633:toxicity; D009581:Nitrofurans / Q000633:toxicity*; D009583:Nitrofurazone / Q000494:pharmacology; D012627:Sebaceous Glands / Q000187:drug effects*; D012867:Skin / Q000187:drug effects
D001551:Benz(a)Anthracenes; D002273:Carcinogens; D007093:Imidazoles; D009153:Mutagens; D009581:Nitrofurans; D009583:Nitrofurazone; D004121:Dimethyl Sulfoxide