A new formula for depigmenting human skin.
Complete depigmentation of the noraml skin of adult male blacks was procured by the daily application for five to seven weeks of a formula consisting of 0.1% tretinoin, 5.0% hydroquinone, 0.1% dexamethasone, and hydrophilic ointment. Depigmentation was not attainable when any one of the components was omitted. The formula was therapeutically effective in treatment of melasma, ephelides, and postinflammatory hyperpigmentation. Senile lentigines were resistant to this therapy.
D000287:Administration, Topical; D044383:Black People; D003907:Dexamethasone / Q000008:administration & dosage / Q000627:therapeutic use*; D004305:Dose-Response Relationship, Drug; D004341:Drug Evaluation; D004359:Drug Therapy, Combination; D006801:Humans; D006854:Hydrocortisone / Q000494:pharmacology; D006873:Hydroquinones / Q000008:administration & dosage / Q000627:therapeutic use*; D007641:Keratolytic Agents / Q000627:therapeutic use; D008297:Male; D009779:Occlusive Dressings; D010859:Pigmentation Disorders / Q000188:drug therapy* / Q000473:pathology; D012867:Skin / Q000166:cytology / Q000528:radiation effects; D014466:Ultraviolet Rays; D014801:Vitamin A / Q000627:therapeutic use*; D044465:White People
D006873:Hydroquinones; D007641:Keratolytic Agents; D014801:Vitamin A; D003907:Dexamethasone; D006854:Hydrocortisone