Propionate metabolism in fetal livers of 15 to 19 weeks' gestation.
Extracts of hepatic tissue obtained from saline-induced abortuses were analyzed for methylmalonyl CoA carbonylmutase (MM) and propionyl CoA carboxylase (PC) activity. MM activity was similar to control values, which suggests that abortion material may be used to confirm the prenatal diagnosis of methylmalonic acidemia. Confirmation of a presumptive propionic acidemia diagnosis is more tenuous due to the instability of PC and the possibility that saline may induce PC activity.
D000028:Abortion, Induced; D001835:Body Weight; D002245:Carbon Dioxide; D002250:Carbon Radioisotopes; D002262:Carboxy-Lyases / Q000032:analysis / Q000378:metabolism*; D004796:Clinical Enzyme Tests; D003067:Coenzymes / Q000032:analysis; D005260:Female; D005333:Fetus / Q000378:metabolism*; D005865:Gestational Age; D006801:Humans; D007535:Isomerases / Q000032:analysis; D008099:Liver / Q000196:embryology / Q000378:metabolism*; D008110:Liver Extracts / Q000032:analysis; D008661:Metabolism, Inborn Errors / Q000175:diagnosis / Q000201:enzymology; D011247:Pregnancy; D011262:Pregnancy Trimester, Second; D011296:Prenatal Diagnosis; D011422:Propionates / Q000032:analysis / Q000378:metabolism*; D014021:Tissue Preservation
D002250:Carbon Radioisotopes; D003067:Coenzymes; D008110:Liver Extracts; D011422:Propionates; D002245:Carbon Dioxide; D002262:Carboxy-Lyases; D007535:Isomerases