Inhibition of immune responses in vitro by specific antiserums to Ia antigens.
Mouse antiserums prepared against Ia antigens, which are products of I (immune response) region genes of the H-2 complex, can inhibit both primary (immunoglobulin M) and secondary (immunoglobulin G) immune responses in vitro by mouse spleen cultures to heterologous erythrocytes. Antiserums directed specifically at products of either the H-2K or H-2D loci have no effect on this response.
D000818:Animals; D000917:Antibody Formation; D004912:Erythrocytes / Q000276:immunology; D005796:Genes; D008040:Genetic Linkage; D006649:Histocompatibility Antigens; D007106:Immune Sera; D007108:Immune Tolerance; D007074:Immunoglobulin G / Q000096:biosynthesis; D007075:Immunoglobulin M / Q000096:biosynthesis; D066298:In Vitro Techniques; D007518:Isoantibodies; D007519:Isoantigens; D051379:Mice; D010527:Perissodactyla / Q000276:immunology; D013154:Spleen / Q000276:immunology
D006649:Histocompatibility Antigens; D007106:Immune Sera; D007074:Immunoglobulin G; D007075:Immunoglobulin M; D007518:Isoantibodies; D007519:Isoantigens