The influence of exogenous estrogen on the circadian periodicity of circulating prolactin in women.
Ethinylestradiol (400 pg/day) does not only stimulate prolactin release in normal cycling women but also modifies the pattern of the circadian periodicity of circulating prolactin: the nocurnal rise is of reduced amplitude but covers a larger part of the nyctohemeral period as compared to the situation during a control period in the same subjects. The values start rising long before sleep, i.e., -t 2 pm, under estrogen treatment and during sleep, i.e., at 4 am, during the control period. In both cases, however, the values remain high until 8 am and are minimal at 12 am.
D000293:Adolescent; D000328:Adult; D002940:Circadian Rhythm / Q000187:drug effects; D004997:Ethinyl Estradiol / Q000494:pharmacology*; D005260:Female; D005640:Follicle Stimulating Hormone / Q000097:blood; D006801:Humans; D007986:Luteinizing Hormone / Q000097:blood; D008598:Menstruation; D011388:Prolactin / Q000097:blood*; D012890:Sleep; D013997:Time Factors
D004997:Ethinyl Estradiol; D011388:Prolactin; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone