The "memory" of salivary gland cells.
In experiments on dogs with a chronic fistual of the submandibular salivary gland intravenous or subcutaneous injection of pilocarpine at intervals of a few days was accompanied by a gradual increase in the volume of saliva, reaching a maximum after 5 injections. Retention of the 'trace' of the action of pilocarpine was observed also in experiments on a dog with vago-sympathetic anastomosis and subsequent parasympathetic denervation of the gland.
D000818:Animals; D003714:Denervation; D004285:Dogs; D010275:Parasympathetic Nervous System / Q000502:physiology; D010862:Pilocarpine / Q000494:pharmacology*; D012469:Salivary Glands / Q000294:innervation / Q000502:physiology*; D012472:Salivation / Q000187:drug effects*
D010862:Pilocarpine