Disappearance of vascular calcifications during treatment of renal osteodystrophy. Two patients treated with high doses of vitamin D and aluminum hydroxide.
In two patients with chronic renal failure, extensive renal osteodystrophy, and vascular calcifications, treatment with high doses of vitamin D3 and aluminum hydroxide was followed by healing of the osteodystrophy and marked resolution of the vascular calcifications. The importance of adequate serum phosphate control during this treatment is stressed. It is postulated that the presence of pathologic bone that was rendered more avid for mineral by the action of vitamin D contributed to the disposal of calcium and phosphorus derived from the calcified vessels and from a positive external balance.
D000328:Adult; D000469:Alkaline Phosphatase / Q000097:blood; D000536:Aluminum Hydroxide / Q000008:administration & dosage* / Q000627:therapeutic use; D001862:Bone Resorption / Q000000981:diagnostic imaging; D002114:Calcinosis / Q000097:blood / Q000188:drug therapy*; D002118:Calcium / Q000097:blood; D012080:Chronic Kidney Disease-Mineral and Bone Disorder / Q000097:blood / Q000188:drug therapy*; D005260:Female; D006801:Humans; D007676:Kidney Failure, Chronic / Q000097:blood / Q000188:drug therapy; D010281:Parathyroid Hormone / Q000097:blood; D010710:Phosphates / Q000097:blood; D010758:Phosphorus / Q000097:blood; D011859:Radiography; D014652:Vascular Diseases / Q000097:blood / Q000188:drug therapy*; D014807:Vitamin D / Q000008:administration & dosage* / Q000627:therapeutic use
D010281:Parathyroid Hormone; D010710:Phosphates; D014807:Vitamin D; D010758:Phosphorus; D000536:Aluminum Hydroxide; D000469:Alkaline Phosphatase; D002118:Calcium