Atropine and exocrine pancreatic secretion in alcohol-fed dogs.
In dogs provided with chroinic pancreatic and gastric fistulas (Thomas canula), one of them vagotomized and alcohol-fed for 17 months with 50% (v/v) intragastric ethanol (0.2gm./kg.), an atropine perfusion (1.0 mg./hr.) superimposed on a continuous i.v. injection of secretion (GIH, 1.0 CU./kg./hr.) and CCK (GIH, Crick, Harper 3.0 U./kg./hr) prevents the excitatory effects on pancreatic secretion of an acute i.v. ethanol infusion (1.3 gm./kg.). In alcohol-fed dogs, the i.v. ehtanol-induced excitatory effect on 'pancreon' is exerted through a cholinergic mechanism, elicited at the hypothalamic bulbar centers and/or the intrapancreatic ganglia.
D000818:Animals; D001285:Atropine / Q000008:administration & dosage / Q000494:pharmacology*; D002766:Cholecystokinin / Q000494:pharmacology; D004285:Dogs; D000431:Ethanol / Q000008:administration & dosage / Q000494:pharmacology*; D005724:Ganglia / Q000187:drug effects / Q000502:physiology; D007031:Hypothalamus / Q000502:physiology; D010179:Pancreas / Q000187:drug effects / Q000294:innervation / Q000378:metabolism*; D010276:Parasympatholytics / Q000494:pharmacology; D010477:Perfusion; D012633:Secretin; D013268:Stimulation, Chemical; D013997:Time Factors; D014630:Vagus Nerve / Q000502:physiology
D010276:Parasympatholytics; D012633:Secretin; D000431:Ethanol; D001285:Atropine; D002766:Cholecystokinin