Treatment of nocardial mycetoma with trimethoprim and sulfamethoxazole.
Two cases of nocardial mycetoma were successfully treated with a mixture of trimethoprim and sulfamethoxazole (Bacterim). The patient in case 1 showed resistance to treatment with antibiotics and sulfamethoxypyridazine, and the causal agent of the disease could not be isolated. In case 2, bone involvement was seen; the causal agent was N asteroides. No adverse effects of the drug occurred in a period of treatment ranging from three to nine months.
D000328:Adult; D004338:Drug Combinations; D005260:Female; D006801:Humans; D008297:Male; D008271:Mycetoma / Q000188:drug therapy* / Q000209:etiology; D009616:Nocardia asteroides; D013420:Sulfamethoxazole / Q000008:administration & dosage* / Q000627:therapeutic use; D013421:Sulfamethoxypyridazine / Q000627:therapeutic use; D013752:Tetracycline / Q000627:therapeutic use; D014295:Trimethoprim / Q000008:administration & dosage* / Q000627:therapeutic use
D004338:Drug Combinations; D014295:Trimethoprim; D013752:Tetracycline; D013420:Sulfamethoxazole; D013421:Sulfamethoxypyridazine