Biochemical modifications of fascia lata for autologous valve replacement.
The biochemistry of canine fascia lata was studied to assess the feasibility of tissue modification with a variety of cross-linking reagents and growth inhibitors in order to provide a more suitable material for heart valves. Chemical determinants for maximal reactivity were consequently established for several growth inhibitors, of which the hydrophobic ligands difluorodinitrobenzene, octadecylamine, and oleylamine were the most effective in preventing invasive cellular growth. This enhanced the longevity of atrial grafts in dogs as judged from morphological and histological examination of excised grafts.
D000596:Amino Acids / Q000032:analysis; D000818:Animals; D000873:Anthracenes / Q000494:pharmacology*; D055598:Chemical Phenomena; D002621:Chemistry; D004285:Dogs; D005069:Evaluation Studies as Topic; D005205:Fascia / Q000637:transplantation*; D005206:Fascia Lata / Q000637:transplantation*; D006349:Heart Valve Diseases / Q000601:surgery*; D006595:Hexosamines / Q000032:analysis; D008055:Lipids / Q000032:analysis; D009281:Naphthalenes / Q000494:pharmacology*; D009578:Nitrobenzenes / Q000494:pharmacology*; D012710:Serum Albumin, Bovine; D012794:Sialic Acids / Q000032:analysis; D014182:Transplantation, Autologous; D014574:Uronic Acids / Q000032:analysis
D000596:Amino Acids; D000873:Anthracenes; D006595:Hexosamines; D008055:Lipids; D009281:Naphthalenes; D009578:Nitrobenzenes; D012794:Sialic Acids; D014574:Uronic Acids; D012710:Serum Albumin, Bovine