title: Follicular carcinoma of the thyroid with functioning metastases and clinical hyperthyroidism.
abstract: Hyperthyroidism associated with metastatic follicular carcinoma of the thyroid gland is rare. In one patient the mass of functioning follicular tissue in the primary and metastatic tumour was so great that excessive amounts of thyroxine and triiodothyronine were produced and, as a result, clinical hyperthyroidism developed. This was in spite of the fact that the activity per unit of tissue was not supranormal and may even have been slightly subnormal. The initial response of the metastases to 131I ablative therapy was excellent.
mesh_terms: D000230:Adenocarcinoma / Q000150:complications* / Q000473:pathology; D005260:Female; D006801:Humans; D006980:Hyperthyroidism / Q000209:etiology*; D007457:Iodine Radioisotopes / Q000627:therapeutic use; D008479:Mediastinal Neoplasms / Q000473:pathology; D008875:Middle Aged; D009362:Neoplasm Metastasis; D012737:Sex Factors; D013964:Thyroid Neoplasms / Q000150:complications* / Q000473:pathology / Q000532:radiotherapy; D013972:Thyrotropin / Q000097:blood; D013974:Thyroxine / Q000097:blood; D014284:Triiodothyronine / Q000097:blood
chemical_list: D007457:Iodine Radioisotopes; D014284:Triiodothyronine; D013972:Thyrotropin; D013974:Thyroxine