Can colonic bacterial metabolites predispose to cholesterol gall stones?
The cholesterol content of biliary lipids increased significantly when 16 healthy volunteers ingested deoxycholic acid (DC) for two weeks in a daily dose of 100-150 mg. Serum cholesterol also fell significantly to 88% of the baseline levels. Since DC is formed in the colon we suggest that populations in whom there is a high colonic absorption of bacterially metabolized cholate--that is, DC--have an increased predisposition to cholesterol gall stones.
D000328:Adult; D000469:Alkaline Phosphatase / Q000097:blood; D001219:Aspartate Aminotransferases / Q000097:blood; D001419:Bacteria / Q000378:metabolism; D001646:Bile / Q000378:metabolism; D001663:Bilirubin / Q000097:blood; D002769:Cholelithiasis / Q000209:etiology*; D002784:Cholesterol / Q000097:blood / Q000378:metabolism*; D003106:Colon / Q000382:microbiology*; D003840:Deoxycholic Acid / Q000378:metabolism*; D005260:Female; D006801:Humans; D008099:Liver / Q000378:metabolism; D008111:Liver Function Tests; D008297:Male; D008875:Middle Aged; D014280:Triglycerides / Q000097:blood
D014280:Triglycerides; D003840:Deoxycholic Acid; D002784:Cholesterol; D001219:Aspartate Aminotransferases; D000469:Alkaline Phosphatase; D001663:Bilirubin