[Effect of heparin on certain indicators of oxidating and energetic processes in experimental endomyocarditis].
The influence of therapeutic dosage of heparin on the content of underoxidized substanses of blood, quantity of ATP, ADP, AMP, creatininphosphate, CPK, and lactatedehydrogenase activity of the heart, liver and kidney tissues was studied in 55 rabbits during horse serum and complex antigen sensitization. Changes in oxidizing and energy processes in experimental endomyocarditis were more prominent in these organs tissues than in blood. Heparin administration increased lactate acid in blood and lactatedehydrogenase activity in the cardiac tissue. Heparin also normalized the increased pyruvic acid level in blood and preserved higher ATP content in tissues. Adenyl system components were balanced in heparinized animals. Heparin influence on oxydizing and energy processes depended upon the basic status of the organism.
D000818:Animals; D003401:Creatine / Q000378:metabolism; D003402:Creatine Kinase / Q000378:metabolism; D004696:Endocarditis / Q000188:drug therapy* / Q000201:enzymology / Q000378:metabolism; D005260:Female; D006493:Heparin / Q000494:pharmacology / Q000627:therapeutic use; D007668:Kidney / Q000378:metabolism; D007770:L-Lactate Dehydrogenase / Q000378:metabolism; D007773:Lactates / Q000378:metabolism; D008099:Liver / Q000378:metabolism; D008297:Male; D009205:Myocarditis / Q000188:drug therapy* / Q000201:enzymology / Q000378:metabolism; D009206:Myocardium / Q000201:enzymology / Q000378:metabolism; D010085:Oxidative Phosphorylation / Q000187:drug effects; D010101:Oxygen Consumption; D011773:Pyruvates / Q000378:metabolism; D011817:Rabbits
D007773:Lactates; D011773:Pyruvates; D006493:Heparin; D007770:L-Lactate Dehydrogenase; D003402:Creatine Kinase; D003401:Creatine
Vliianie geparina na nekotorye pokazateli okislitel'nykh i energeticheskikh protsessov pre eksperimental'nom endomiokardite