Substrate incorporation into hepatic lipids and proteins in vitro in patients with pre-beta hyperlipoproteinemia.
Fifty-three patients operated on for uncomplicated gallstone disease have been studied concerning the hepatic synthesis rate in vitro of glycerides and proteins. Thirteen of the patients had pre-beta hyperlipoproteinemia. Five of them and four normolipoproteinemic patients were fed a sucrose-enriched diet for two weeks prior to the operation. In the non-sucrose-fed hyperlipoproteinemic patients the liver concentration of triglycerides (TG) and the incorporation rate of precursors into TG were increased. A significant correlation was found between the synthesis rate of TG in liver tissue and the plasma TG concentration in these hyperlipoproteinemic patients. After sucrose feeding of patients with hyperlipoproteinemia the concentration of phosphoglycerides  (PG) the incorporation rate of labelled precursors in PG were significantly lower than in normolipoproteinemic patients and in hyperlipoproteinemic patients on an ordinary diet. The incorporation rate of leucine into hepatic proteins and the hepatic protein concentration were the same in non-sucrose-fed controls, sucrose-fed, and non-sucrose-fed hyperlipoproteinemic patients. The results indicate an increased vulnerability of the hepatic PG and protein metabolism for dietary sucrose in patients with pre-beta hyperlipoproteinemia.
D002784:Cholesterol / Q000097:blood; D004032:Diet; D005260:Female; D005632:Fructose / Q000378:metabolism; D005990:Glycerol / Q000378:metabolism; D006801:Humans; D006949:Hyperlipidemias / Q000378:metabolism*; D007930:Leucine / Q000378:metabolism; D050356:Lipid Metabolism; D008099:Liver / Q000378:metabolism*; D008112:Liver Glycogen / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D011506:Proteins / Q000378:metabolism*; D013395:Sucrose; D014280:Triglycerides / Q000097:blood / Q000378:metabolism
D008112:Liver Glycogen; D011506:Proteins; D014280:Triglycerides; D005632:Fructose; D013395:Sucrose; D002784:Cholesterol; D007930:Leucine; D005990:Glycerol