Djungarian hamster-a suitable tool for cancer research and cytogenetic studies.
The Djungarian hamster, bred under usual laboratory conditions, developed different spontaneous neoplasms, most often mammary and skin cancers. Some mammary tumors were serially transplanted to noninbred animals. This hamster was susceptible to some chemical carcinogens and oncogenic viruses but resistant to others. It had comparatively few chromosomes (2n equal to 28), most of which could be recognized even in conventionally stained preparations. The chromosome-breaking effect of gamma-rays, chemical carcinogens, and viruses was studied with primary cultures of cells. Several transformed cell lines were developed. Karyotype abnormalities were generally not seen in primary and induced neoplasms. This hamster is a new suitable tool for cancer research and cytogenetic studies.
D000818:Animals; D002273:Carcinogens; D002471:Cell Transformation, Neoplastic; D002478:Cells, Cultured; D002869:Chromosome Aberrations; D002875:Chromosomes / Q000187:drug effects / Q000528:radiation effects; D006224:Cricetinae; D004195:Disease Models, Animal; D007621:Karyotyping; D008325:Mammary Neoplasms, Experimental / Q000235:genetics; D009368:Neoplasm Transplantation; D009374:Neoplasms, Experimental / Q000139:chemically induced / Q000235:genetics; D009858:Oncogenic Viruses; D012878:Skin Neoplasms / Q000235:genetics; D014184:Transplantation, Homologous
D002273:Carcinogens