The effect of LSD and 2-bromo LSD on the DOPA accumulation after central and peripheral decarboxylase inhibition.
LSD and BOL were found to be equally potent in increasing the rat brain DOPA accumulation after decarboxylase inhibition. However, at the doses selected, the DOPA levels after haloperidol and apomorphine were increased by LSD but not by BOL. It is suggested that this difference is due to LSD's activating effect on central serotoninergic receptors.
D000818:Animals; D065105:Aromatic Amino Acid Decarboxylase Inhibitors; D001921:Brain / Q000187:drug effects / Q000378:metabolism; D004295:Dihydroxyphenylalanine / Q000378:metabolism*; D008238:Lysergic Acid Diethylamide / Q000031:analogs & derivatives / Q000494:pharmacology*; D008297:Male; D010646:Phentolamine / Q000494:pharmacology; D011433:Propranolol / Q000494:pharmacology; D051381:Rats; D013268:Stimulation, Chemical
D065105:Aromatic Amino Acid Decarboxylase Inhibitors; D004295:Dihydroxyphenylalanine; D008238:Lysergic Acid Diethylamide; D011433:Propranolol; D010646:Phentolamine