Cross-linked hemoglobins as potential plasma protein extenders.
Reaction of hemoglobin solutions with members of a class of diimidate esters leads to the formation of cross-linked intermolecular or intramolecular complexes depending on the relative concentration of hemoglobin and the length of the carbon chain of the imidate esters. The products have a life-span in the circulation of rabbits significantly greater than that of unmodified hemoglobin and it is suggested that they may serve as plasma protein extenders.
D000596:Amino Acids / Q000032:analysis; D000818:Animals; D055598:Chemical Phenomena; D002621:Chemistry; D004591:Electrophoresis, Polyacrylamide Gel; D004952:Esters; D006454:Hemoglobins / Q000032:analysis; D006801:Humans; D007094:Imides / Q000494:pharmacology; D008970:Molecular Weight; D010455:Peptides / Q000032:analysis; D010952:Plasma Substitutes; D011817:Rabbits; D012967:Sodium Dodecyl Sulfate / Q000494:pharmacology
D000596:Amino Acids; D004952:Esters; D006454:Hemoglobins; D007094:Imides; D010455:Peptides; D010952:Plasma Substitutes; D012967:Sodium Dodecyl Sulfate