Uptake of carbon monoxide in blood of miniture pigs and other mammals.
Different affinities of blood for CO were observed in in vivo and in vitro experiments. Hamsters showed the greatest relative affinity (1.0), the corresponding value for rats was 0.8, for pigs 0.74 and for rabbits 0.58. The upward shift of the saturation curves was dependent on the rate of respiratory exchange per unit of body weight, e.g. the curves were less steep for pigs than for rabbits. After increased motor activity the equilibrium saturation of CO in blood is reached more rapidly. From the results of in vitro experiments the following affinity constants for the blood of different species could be calculated: pig K = 130, hamster K = 181, rat I = 141, rabbit K = 109. For equal atmospheric CO concentrations the saturation values were lower (37-40%) in experiments in vitro than in vivo. Similar saturation values were obtained with light excluded, when O2 concentration was decreased to the level of alveolar oxygen concentration. With regard to the affinity of blood for CO, the blood of domestic pigs did not differ from that of minature pigs in in vitro experiments.
D000818:Animals; D001835:Body Weight; D002248:Carbon Monoxide / Q000097:blood* / Q000378:metabolism; D002849:Chromatography, Gas; D006224:Cricetinae; D005260:Female; D006454:Hemoglobins / Q000032:analysis; D007700:Kinetics; D009043:Motor Activity; D010101:Oxygen Consumption; D011817:Rabbits; D051381:Rats; D012119:Respiration / Q000187:drug effects; D013045:Species Specificity; D013552:Swine
D006454:Hemoglobins; D002248:Carbon Monoxide