In vivo hemolytic potency and binding of chlorpromazine to plasma protein and erythrocytes of rat and dog (38579).
It was demonstrated by equilibrium dialysis that dog red cells have a greater ability to bind chlorpromazine than rat red cells.  Dog plasma was shown to have a greater ability to bind chlopromazine than rat plasma although this difference was not statistically significant.  In the presence of CPZ (10-3M), the 50% hemolysis time of dog red cells suspended in homologous plasma or in 0.9% buffered NaCl solution was much greater than that of rat red cells treated in the same manner.  The 50% hemolysis time of dog red cells suspended in homologous plasma was considerably shortened when they were suspended in rat plasma.  Conversely, an increase in the 50% hemolysis time was obtained when rat red cells were suspended in dog plasma.  Several possibilities for the slower rate of CPZ-induced hemolysis of dog red cells as compared to rat has been discussed in the present report.
D000818:Animals; D001798:Blood Proteins / Q000378:metabolism*; D002746:Chlorpromazine / Q000378:metabolism* / Q000494:pharmacology*; D004285:Dogs / Q000378:metabolism*; D004912:Erythrocytes / Q000187:drug effects / Q000378:metabolism*; D006400:Hematocrit; D009994:Osmolar Concentration; D011485:Protein Binding; D051381:Rats / Q000378:metabolism*
D001798:Blood Proteins; D002746:Chlorpromazine