Production of extracellular lysine by a strain of Bacillus coagulans. Identification and requirements for growth and lysine accumulation.
A naturally deficient thiamine and methionine requiring strain of Bacillus coagulans (Ms 5) accumulates lysine in medium only when exogenous pyridoxine (optimal concentration, 0.1 mu g/ml) are supplied. Threonine exerts an inhibitory effect at higher  concentrations but pyridoxine does not.
D001407:Bacillus / Q000145:classification / Q000254:growth & development / Q000378:metabolism*; D002854:Chromatography, Paper; D003124:Colorimetry; D008239:Lysine / Q000096:biosynthesis*; D008715:Methionine / Q000378:metabolism; D009154:Mutation; D011736:Pyridoxine / Q000378:metabolism; D013831:Thiamine / Q000378:metabolism; D013912:Threonine / Q000378:metabolism
D013912:Threonine; D008715:Methionine; D008239:Lysine; D011736:Pyridoxine; D013831:Thiamine