Inhibition of cholesterol esterification by polyene antibiotics in blood plasma.
The inhibition of the lecithin-cholesterol acyltransferase reaction in human plasma by the polyene antibiotics, levorine and amphotericin B, has been demonstrated by in vitro experiments. It is suggested that the inhibition of the esterification reaction is the result of interaction between polyenes and non-esterified cholesterol.
D000217:Acyltransferases / Q000037:antagonists & inhibitors* / Q000097:blood; D000666:Amphotericin B / Q000494:pharmacology*; D000935:Antifungal Agents / Q000494:pharmacology*; D002250:Carbon Radioisotopes; D002784:Cholesterol; D006801:Humans; D008074:Lipoproteins / Q000097:blood; D010713:Phosphatidylcholines; D011090:Polyenes / Q000494:pharmacology
D000935:Antifungal Agents; D002250:Carbon Radioisotopes; D008074:Lipoproteins; D010713:Phosphatidylcholines; D011090:Polyenes; D000666:Amphotericin B; D002784:Cholesterol; D000217:Acyltransferases