[Neutropenia in disorders of the neutrophil motility].
A 51-year-old patient exhibited severe neutropenia over a period of 12 months following lobectomy for carcinoma of the lung. Marrow neutrophil mass and marrow neutrophil production were measured quantitatively and were within normal limits. Mobilization into a skin window was absent. A defect in neutrophil motility could be demonstrated in vitro and was confirmed in vivo by poor neutrophil release from the marrow following injection of hydrocortisone; it thus represented a lazy leukocyte syndrome of the adult.
D000380:Agranulocytosis / Q000209:etiology*; D001854:Bone Marrow Cells; D002465:Cell Movement / Q000187:drug effects; D006801:Humans; D006854:Hydrocortisone / Q000494:pharmacology; D008175:Lung Neoplasms / Q000601:surgery; D008297:Male; D008875:Middle Aged; D009503:Neutropenia / Q000209:etiology*; D009504:Neutrophils / Q000502:physiology; D011013:Pneumonectomy; D012884:Skin Window Technique
D006854:Hydrocortisone
Neutropenie bei gestörter Motilität der Neutrophilen