Effect of litter size on milk yield in the rat.
The amount of milk removed from rats during 1 hour's suckling after a separation period of 8 hours was estimated by weighing their pups.  In the 1st experiment litters of 9 pups were suckled by all rats.  At test sucklings held daily on days 6-15 of lactation, pups were reallocated to give 3, 6, 9, 12 or 15 pups per dam.  The largest amount of milk was removed at suckling by groups of 12 pups. In a 2nd experiment, rats were constantly sucked by litters of either 3, 6, 9, 12 or 15 pups from birth to slaughter at 15 days post partum.  Rats with 12 and 15 pups yielded the most milk, nearly twice as much as those suckling only 6 or 9 pups.  Litters of 3 pups consumed less than 1/3 of the amount consumed by litters of 6 or 9 pups.
D000818:Animals; D000831:Animals, Newborn; D001835:Body Weight; D005260:Female; D007743:Labor, Obstetric; D007774:Lactation; D008892:Milk / Q000378:metabolism*; D011247:Pregnancy; D051381:Rats / Q000502:physiology*; D013997:Time Factors