[Coronary collateral vessels after long-term treatment with fendiline hydrochloride in a double-blind study (author's transl)].
After long-therapy with 5 mg/kg body-weight of N-(2-benzhydryl-ethyl)-N-(1-phenyl-ethyl)amine hydrochloride (fendiline hydrochloride, Sensit) in dogs the development of functioning coronary collateral vessels can be proven by filling the vessel system with synthetic resin. From earlier studies, it is known that coronary collateral vessels can protect the heart from the consequences of stenoses and tissue damage due to hypoxia.
D000818:Animals; D001559:Benzhydryl Compounds / Q000008:administration & dosage / Q000494:pharmacology; D002986:Clinical Trials as Topic; D003097:Collateral Circulation / Q000187:drug effects*; D003331:Coronary Vessels / Q000187:drug effects* / Q000502:physiology; D004285:Dogs; D004334:Drug Administration Schedule; D004353:Drug Evaluation, Preclinical; D005260:Female; D008026:Ligation; D008297:Male; D010627:Phenethylamines / Q000008:administration & dosage / Q000494:pharmacology*; D013997:Time Factors; D014665:Vasodilator Agents
D001559:Benzhydryl Compounds; D010627:Phenethylamines; D014665:Vasodilator Agents
Koronargefässkollateralen nach oraler Langzeitbehandlung mit Fendilin-hydrochlorid im Doppelblindversuch