Short-term inhalation toxicity of halogenated hydrocarbons: effects on fasting rats.
Male rats, fasted overnight (18 hours), and exposed to various materials in inhalation were more sensitive to the hepatotoxic effects of carbon tetrachloride, 2-chlorobutadiene, 1,1-dibromoethylene, and 1,1-dichloroethylene (DCE). Vinyl chloride monomer and 1,1-difluoroethylene were not acutely hepatotoxic in fed or fasted rats at any concentration tested. Vinyl chloride monomer when administered simultaneously with DCE prevented the injury associated with DCE inhalation in fasted rats. This prevention of injury may be a result of a competitive interaction since the effect was concentration dependent.
D000336:Aerosols; D000410:Alanine Transaminase / Q000097:blood; D000429:Alcohol Oxidoreductases / Q000097:blood; D000818:Animals; D001273:Atmosphere Exposure Chambers; D002070:Butadienes / Q000031:analogs & derivatives / Q000633:toxicity; D002251:Carbon Tetrachloride / Q000008:administration & dosage / Q000633:toxicity; D005030:Ethylenes / Q000031:analogs & derivatives / Q000633:toxicity; D005215:Fasting; D006842:Hydrocarbons, Brominated / Q000633:toxicity; D006843:Hydrocarbons, Chlorinated / Q000633:toxicity; D006845:Hydrocarbons, Fluorinated / Q000633:toxicity; D006846:Hydrocarbons, Halogenated / Q000008:administration & dosage / Q000633:toxicity*; D007656:Ketoglutaric Acids; D008099:Liver / Q000187:drug effects; D008297:Male; D051381:Rats; D013012:Sorbitol; D014753:Vinyl Compounds / Q000633:toxicity
D000336:Aerosols; D002070:Butadienes; D005030:Ethylenes; D006842:Hydrocarbons, Brominated; D006843:Hydrocarbons, Chlorinated; D006845:Hydrocarbons, Fluorinated; D006846:Hydrocarbons, Halogenated; D007656:Ketoglutaric Acids; D014753:Vinyl Compounds; D013012:Sorbitol; C007319:1,1-dibromoethylene; D002251:Carbon Tetrachloride; D000429:Alcohol Oxidoreductases; D000410:Alanine Transaminase