Human cells repair DNA damaged by nitrous acid.
Cultured fibroblasts from normal persons or persons afflicted by xeroderma pigmentosum were used as hosts for adenovirus 2 infection. With xeroderma cells as hosts, nitrous acid-treated virus showed less plaque-forming ability than when normal cells were used, indicating that DNA damaged by nitrous acid is at least partly repaired by normal human cells.
D000256:Adenoviridae / Q000187:drug effects; D002478:Cells, Cultured; D004260:DNA Repair; D005347:Fibroblasts / Q000187:drug effects / Q000382:microbiology; D006801:Humans; D009573:Nitrites / Q000494:pharmacology*; D009608:Nitrous Acid / Q000494:pharmacology*; D014983:Xeroderma Pigmentosum / Q000473:pathology
D009573:Nitrites; D009608:Nitrous Acid