title: Local spinal cord blood flow in experimental traumatic myelopathy.
abstract: Focal blood flow was measured in the lateral funiculus and center of the spinal cord in the rhesus monkey both before and after a 600 gm-cm injury at T-10. Measurements made by the hydrogen clearance technique showed that blood flow in the lateral funiculus more than doubled within 4 hours after injury, returned to normal by 8 hours, and remained in the normal range for 24 hours. At no time was a hypoperfusion in the lateral funiculus present. Blood flow in the center of the spinal cord, at the level of the lesion, began to fall within 1 hour following injury and continued to fall for 4 hours. These data challenge the notion that spreading ischemia of the white matter is an important factor in the pathophysiology of experimental spinal cord injury.
mesh_terms: D000818:Animals; D001776:Blood Circulation Time; D007238:Infarction / Q000209:etiology; D007511:Ischemia / Q000209:etiology; D008253:Macaca mulatta; D010264:Paraplegia / Q000209:etiology; D013116:Spinal Cord / Q000098:blood supply*; D013119:Spinal Cord Injuries / Q000150:complications / Q000503:physiopathology*; D013904:Thoracic Vertebrae / Q000293:injuries; D013997:Time Factors