title: Genetic recombination in Nocardia mediterranei.
abstract: A system of genetic recombination in Nocardia mediterranei ATCC 13685 is described. This strain produces a mixture of several rifamycin antibiotics. Using haploid recombinant selection and analysis procedures similar to those applied to Streptomyces coelicolor A3(2), 14 auxotrophic markers and 1 streptomycin resistance marker were located on a circular linkage map. The linkage map of N. mediterranei seems to be similar to that of S. coelicolor A3(2).
mesh_terms: D000596:Amino Acids / Q000378:metabolism; D002874:Chromosome Mapping; D003433:Crosses, Genetic; D004352:Drug Resistance, Microbial; D005796:Genes; D008040:Genetic Linkage; D006238:Haploidy; D007930:Leucine / Q000378:metabolism; D009153:Mutagens; D009154:Mutation; D009604:Nitrosoguanidines; D009615:Nocardia / Q000187:drug effects / Q000378:metabolism; D011995:Recombination, Genetic; D012294:Rifamycins / Q000096:biosynthesis; D013307:Streptomycin / Q000494:pharmacology; D014466:Ultraviolet Rays; D014498:Uracil / Q000378:metabolism
chemical_list: D000596:Amino Acids; D009153:Mutagens; D009604:Nitrosoguanidines; D012294:Rifamycins; D014498:Uracil; D007930:Leucine; D013307:Streptomycin