title: The immune response to phi chi 174 in man. II. Primary and secondary antibody production in patients with Crohn's disease.
abstract: 10 patients with Crohn's disease in various states of activity have been injected with 3.3 times 10-9 plaque-forming units of the bacteriophage phi chi 174, as a test for their capacity to produce antibodies. 9 patients had a completely normal primary and secondary antibody response. One patient had higher levels of preimmunization antibodies than have been encountered in normal subjects and developed a secondary (IgG) response to the first dose of antigen. We conclude that there is no evidence of a general disturbance of antibody-producing capacity in subjects with Crohn's disease.
mesh_terms: D000328:Adult; D000917:Antibody Formation; D001798:Blood Proteins / Q000032:analysis; D001809:Blood Viscosity; D003090:Coliphages / Q000276:immunology*; D003424:Crohn Disease / Q000097:blood / Q000276:immunology*; D005260:Female; D006801:Humans; D007114:Immunization; D007074:Immunoglobulin G / Q000032:analysis; D007075:Immunoglobulin M / Q000032:analysis; D007156:Immunologic Memory; D007958:Leukocyte Count; D008297:Male; D008875:Middle Aged
chemical_list: D001798:Blood Proteins; D007074:Immunoglobulin G; D007075:Immunoglobulin M