[Fungicidal and phagocytic activity against "Candida albicans" of human neutrophils in serum depleted in C3 and C4 (author's transl)].
Cases of systemic infections caused by C. albicans are increasing in number and the kidney appears to be involved more often than any other tissue. The renal medulla is especially susceptible to infection by C. albicans and by bacteria - Previous works has showed that this is essentially due to hyperosmolality and to inactivation of the complement system. Polymorphs are one of the main host defense mechanisms against C. albicans and the authors have studied their power of phagocytosis against Candida and fongicidal activity in serum depleted in C3 and C4. Both are found to be normal.
D000818:Animals; D002176:Candida albicans; D002177:Candidiasis; D003176:Complement C3 / Q000502:physiology; D003181:Complement C4 / Q000502:physiology; D006801:Humans; D007679:Kidney Medulla; D008297:Male; D051379:Mice; D009393:Nephritis / Q000382:microbiology; D009504:Neutrophils / Q000502:physiology*; D010587:Phagocytosis
D003176:Complement C3; D003181:Complement C4
Pouvoirs phagocytaire et fongicide envers Candida albicans des polynucléaires neutrophiles humains en présence de sérum dépourvu de C3 et C4