Diagnosis and prognosis in colon cancer based on a profile in immune reactivity.
An immunologic profile consisting of measurements of circulating carcinoembryonic antigen (CEA), tumor antigen-induced inhibition of monomuclear cell migration (IMM) and skin reactivity to purified protein derivative, streptokinase-streptodornase, and mumps was assessed as a diagnostic and prognostic tool in 16 patients with colon cancer. Preoperatively, 10 of 14 patients tested had elevated CEA, 12 of 12 showed tumor antigen-induced IMM, and 10 of 11 failed to react to 2 or more recall antigens. Potential surgical cure (7 patients) was accompanied by normal CEA in 4, absent tumor antigen-induced IMM in all 7, and increased skin-test reactivity in 6. Disseminated cancer (9 patients) was associated with elevated CEA in all 9, with absent IMM in all 7 and with suppressed skin-test reactivity in 6 of 9.
D000328:Adult; D000368:Aged; D002272:Carcinoembryonic Antigen / Q000032:analysis; D002464:Cell Migration Inhibition; D003110:Colonic Neoplasms / Q000175:diagnosis* / Q000276:immunology / Q000601:surgery; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009107:Mumps / Q000276:immunology; D009362:Neoplasm Metastasis; D011379:Prognosis; D012882:Skin Tests; D013299:Streptodornase and Streptokinase / Q000276:immunology; D014374:Tuberculin Test
D002272:Carcinoembryonic Antigen; D013299:Streptodornase and Streptokinase