title: Some effects of ovarian hormones on food intake and body weight in female rats.
abstract: Ovarian steroids affect the food intake and body weight of rats. These effects are probably mediated by estradiol and progesterone, since these 2 hormones are more effective than their principal metabolites (estrone and 5alpha-pregnane-3,20-dione, respectively) in altering the food intake and body weight of ovariectomized rats. Estradiol seems to affect food intake by lowering the set point about which body weight is regulated in a dose-dependent fashion. These actions of estradiol can be attenuated or completely blocked by concurrent injections of progesterone. Estradiol-treated ovariectomized rats are far more responsive to the weight- and appetite-promoting actions of progesterone than are ovariectomized-adrenalectomized rats, suggesting that the principal action of progesterone on energy balance may be to interfere with the effects of estradiol.
mesh_terms: D000311:Adrenal Glands / Q000502:physiology; D000315:Adrenalectomy; D000818:Animals; D001835:Body Weight / Q000187:drug effects*; D002369:Castration; D004958:Estradiol / Q000494:pharmacology*; D004970:Estrone / Q000494:pharmacology; D005247:Feeding Behavior / Q000187:drug effects*; D005260:Female; D010053:Ovary / Q000502:physiology; D011277:Pregnanediones / Q000494:pharmacology; D011374:Progesterone / Q000494:pharmacology*; D051381:Rats; D013997:Time Factors
chemical_list: D011277:Pregnanediones; D004970:Estrone; D011374:Progesterone; D004958:Estradiol