Effect of lipids on glucagon secretion in man.
Animal experiments have suggested a FFA control mechanism for glucagon secretion. In man, the potent effect of FFA on HGH secretion and the similarity of the secretory control mechanisms for HGH and IRG also support a role of FFA in IRG secretion. Our studies in man in which plasma FFA were elevated by either an oral lipid emulsion (Lipomul) or an intravenous lipid suspension (Intralipid)suggest only a minor role of lipids in control of IRG secretion. Plasma FFA and triglyceride elevations did not suppress arginine- or hypoglycemia-induced plasma IRG elevations, but an inhibitory effect of Intralipid on basal plasma IRG concentrations was observed. Although nicotinic acid administration, which caused a depression in plasma FFA, did elevate plasma IRG, the IRG elevation was considered more likely a consequence of stress induced by the drug. The failure of lipids to inhibit IRG secretion at FFA concentrations inhibiting HGH secretion indicates a dissociation in the secretory control mechanisms of the two hormones.
D000284:Administration, Oral; D000328:Adult; D000906:Antibodies; D001120:Arginine / Q000494:pharmacology; D001786:Blood Glucose; D004041:Dietary Fats; D004655:Emulsions; D005230:Fatty Acids, Nonesterified / Q000008:administration & dosage / Q000097:blood / Q000494:pharmacology; D005934:Glucagon / Q000097:blood* / Q000276:immunology; D013006:Growth Hormone / Q000097:blood; D006493:Heparin / Q000008:administration & dosage / Q000494:pharmacology; D006801:Humans; D007275:Injections, Intravenous; D007328:Insulin / Q000494:pharmacology; D008055:Lipids / Q000494:pharmacology*; D008297:Male; D009539:Nicotinic Acids / Q000494:pharmacology; D009821:Oils; D013997:Time Factors; D014280:Triglycerides / Q000097:blood
D000906:Antibodies; D001786:Blood Glucose; D004041:Dietary Fats; D004655:Emulsions; D005230:Fatty Acids, Nonesterified; D007328:Insulin; D008055:Lipids; D009539:Nicotinic Acids; D009821:Oils; D014280:Triglycerides; D013006:Growth Hormone; D006493:Heparin; D005934:Glucagon; D001120:Arginine