The management of organophosphate intoxication.
This review attempts to reiterate the problem of organophosphate intoxication and the pathophysiologic problems created by these compounds. A discussion of management is included. The case reported of a two-year old child serves to illustrate the tremendously high doses of atropine which may be required to block the acetylcholine accumulated at cholinergic synapses as a result of phosphorylation of acetylcholinesterase by organophosphorus compounds.
D000110:Acetylcholinesterase / Q000378:metabolism; D001285:Atropine / Q000008:administration & dosage / Q000627:therapeutic use; D002675:Child, Preschool; D004359:Drug Therapy, Combination; D006801:Humans; D006868:Hydrolysis; D007306:Insecticides / Q000378:metabolism / Q000506:poisoning*; D008297:Male; D009943:Organophosphorus Compounds; D011041:Poisoning / Q000175:diagnosis / Q000188:drug therapy; D011220:Pralidoxime Compounds / Q000008:administration & dosage / Q000627:therapeutic use; D012121:Respiration, Artificial
D007306:Insecticides; D009943:Organophosphorus Compounds; D011220:Pralidoxime Compounds; D001285:Atropine; D000110:Acetylcholinesterase