Dilutional hyponatremia due to diazoxide-produced polydipsia.
Subcutaneous injection of diazoxide every 3 hr for a total of 5 doses in 15 hr produced a state of elevated drinking and antidiuresis in rats resulting in a massive, positive, self-imposed water load. Dilutional hyponatremia was present, but not serum hyposmolality, owing to the increased serum glucose and BUN. The mechanism by which diazoxide produces a polydipsia even in the presence of an accumulating water load may illuminate the genesis of other pathophysiological dilutional states.
D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D001810:Blood Volume; D003981:Diazoxide / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D004327:Drinking Behavior / Q000187:drug effects*; D006400:Hematocrit; D007010:Hyponatremia / Q000139:chemically induced / Q000503:physiopathology*; D008297:Male; D009994:Osmolar Concentration; D051381:Rats; D012964:Sodium / Q000097:blood; D013997:Time Factors; D014508:Urea / Q000097:blood
D001786:Blood Glucose; D014508:Urea; D012964:Sodium; D003981:Diazoxide