Increased loss of duplicated genes in streptomycin-resistant (strA) mutants of Escherichia coli k-12.
The recombination-dependent loss of a duplicated portion of the Escherichia coli chromosome is five- to tenfold greater in strains containing streptomycin resistance (strA) mutations than in the strA+ parental strain. Streptomycin (500 mug/ml) partially reverses the increase. These results suggest an interaction between strA mutations and recombination.
D004352:Drug Resistance, Microbial; D004926:Escherichia coli / Q000187:drug effects* / Q000378:metabolism; D005796:Genes; D007211:Indoles / Q000378:metabolism; D009154:Mutation; D011995:Recombination, Genetic; D013307:Streptomycin / Q000494:pharmacology*; D014364:Tryptophan / Q000096:biosynthesis; D062367:ortho-Aminobenzoates / Q000494:pharmacology
D007211:Indoles; D062367:ortho-Aminobenzoates; D014364:Tryptophan; D013307:Streptomycin