Effects of methylprednisolone, glucagon, and allopurinol in the protection of pancreaticoduodenal allografts perfused for twenty-four hours.
To establish a model for 24 hours of hypothermic pulsatile perfusion-preservation, methylprednisolone, glucagon, and allopurinol were added to the perfusate of five groups of canine pancreaticoduodenal segments. Results after transplantation showed that neither allopurinol nor glucagon, when used alone, had any beneficial effect on the segments. The segments perfused with the additive combination of methylprednisolone and glucagon had the best results after transplant.
D000493:Allopurinol / Q000494:pharmacology*; D000818:Animals; D004285:Dogs; D004386:Duodenum / Q000187:drug effects / Q000637:transplantation*; D005934:Glucagon / Q000494:pharmacology*; D008775:Methylprednisolone / Q000494:pharmacology*; D009926:Organ Preservation / Q000379:methods*; D010179:Pancreas / Q000187:drug effects; D016035:Pancreas Transplantation; D010477:Perfusion; D014021:Tissue Preservation / Q000379:methods*; D014022:Tissue Survival / Q000187:drug effects*; D014184:Transplantation, Homologous
D000493:Allopurinol; D005934:Glucagon; D008775:Methylprednisolone