Extreme toxicity from combustion products of a fire-retarded polyurethane foam.
The products from nonflaming combustion of wood and a trimethylol-propane-based rigid-urethane foam that was not fire-retarded produced elevated carboxyhemoglobin levels but no abnormal neurological effects. However, when this type of foam contained a reactive phosphate fire retardant, the combustion products caused grand mal seizures and death in rats. The toxic combustion product responsible for the seizures has been identified as 4-ethyl-1-phospha-2,6,7-trioxabicyclo(2.2.2.)octane-1-oxide.
D000818:Animals; D001273:Atmosphere Exposure Chambers; D001643:Bridged Bicyclo Compounds / Q000633:toxicity*; D001952:Bridged-Ring Compounds / Q000633:toxicity*; D002248:Carbon Monoxide / Q000097:blood*; D002263:Carboxyhemoglobin / Q000032:analysis; D003498:Cyclic P-Oxides / Q000633:toxicity*; D004569:Electroencephalography; D006358:Hot Temperature; D011140:Polyurethanes / Q000633:toxicity*; D051381:Rats; D012018:Reflex / Q000187:drug effects; D012640:Seizures / Q000139:chemically induced*; D012906:Smoke; D014934:Wood
D001643:Bridged Bicyclo Compounds; D001952:Bridged-Ring Compounds; D003498:Cyclic P-Oxides; D011140:Polyurethanes; D012906:Smoke; D002248:Carbon Monoxide; D002263:Carboxyhemoglobin