The pharmacological assessment of single drugs and drug combinations in exercise-induced asthma.
The relative effectiveness of ephedrine, theophylline, hydroxyzine, and their combinations in relieving cycloergometer exercise-induced asthma were studied in 16 children and adolescents. Ephedrine had no effect on post-exercise asthma, hydroxyzine had weak effect on hastening recovery, while theophylline modified on the post-exercise response significantly. The three drugs together produced an additive effect superior to that of theohylline alone.
D000293:Adolescent; D001249:Asthma / Q000209:etiology* / Q000517:prevention & control; D002648:Child; D002986:Clinical Trials as Topic; D004338:Drug Combinations; D004809:Ephedrine / Q000627:therapeutic use*; D005541:Forced Expiratory Volume; D006801:Humans; D006919:Hydroxyzine / Q000627:therapeutic use*; D008448:Maximal Expiratory Flow Rate; D008450:Maximal Midexpiratory Flow Rate; D005082:Physical Exertion; D010919:Placebos; D011674:Pulse; D013806:Theophylline / Q000627:therapeutic use*; D014797:Vital Capacity; D014939:Work of Breathing
D004338:Drug Combinations; D010919:Placebos; D006919:Hydroxyzine; D013806:Theophylline; D004809:Ephedrine