Prevention of porcine malignant hyperthermia by epidural block.
Malignant hyperthermia in susceptible swine was completely blocked by epidural anesthesia with lidocaine. Incomplete epidural anesthesia modified the disease but did not prevent it. These studies indicate the importance of the nervous system in the triggering of malignant hyperthermia. (Key words: Hyperthermia, malignant; Anesthetic technique, peridural.).
D000767:Anesthesia, Epidural / Q000379:methods; D000818:Animals; D001831:Body Temperature; D002490:Central Nervous System / Q000503:physiopathology; D005260:Female; D006221:Halothane / Q000008:administration & dosage; D008012:Lidocaine; D008297:Male; D008305:Malignant Hyperthermia / Q000139:chemically induced / Q000209:etiology / Q000517:prevention & control*; D009127:Muscle Rigidity / Q000139:chemically induced / Q000209:etiology; D013552:Swine; D013997:Time Factors
D008012:Lidocaine; D006221:Halothane