[Effect of monoamine oxidase inhibitors on the phagocytic activity of macrophages].
Preparations studied in this work with the properties of monoaminoxidase (MAO) inhibitors caused a reduction of the phagocytic activity of cells and degeneration of the cell culture. By the extent of the toxic action on the macrophage culture the preparations could be distributed in the following order: chloracizine, chlorpromazine, vetrazine, indopan; biogenic amine serotonin influenced the phagocytic activity of cells only in very high concentrations. Macrophage cultivation in a medium containing MAO inhibitors led to quantitative and qualitative changes in the acid phosphatase granules. Reduction of the phagocytic capacity of macrophages and the changes in the lysosomal apparatus of the cells proved to depend on the increase in the concentration of the inhibitors in the culture medium and the duration of their action on the macrophage cells.
D000818:Animals; D001202:Ascitic Fluid / Q000166:cytology; D002746:Chlorpromazine / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D006168:Guinea Pigs; D006834:Hydrazines / Q000494:pharmacology; D066298:In Vitro Techniques; D008264:Macrophages / Q000187:drug effects; D008996:Monoamine Oxidase Inhibitors / Q000494:pharmacology*; D010587:Phagocytosis / Q000187:drug effects*; D010640:Phenothiazines / Q000494:pharmacology; D012701:Serotonin / Q000494:pharmacology; D014363:Tryptamines / Q000494:pharmacology; D014665:Vasodilator Agents / Q000494:pharmacology
D006834:Hydrazines; D008996:Monoamine Oxidase Inhibitors; D010640:Phenothiazines; D014363:Tryptamines; D014665:Vasodilator Agents; D012701:Serotonin; D002746:Chlorpromazine
Vliianie preparatov, obladaiushchikh svoĭstvami ingibitorov monoaminoksidazy, na fagotsitarnuiu aktivnost' makrofagov