Lack of erythropoietic inhibitory effect of serum from patients withe congenital pure red cell aplasia.
The serum from five children with congenital pure red cell aplasia demonstrated no erythropoietic inhibitory effect either in vivo in animals or in vitro. The significance of immunosuppressive therapy in this disease is discussed.
D000741:Anemia, Aplastic / Q000097:blood / Q000151:congenital*; D000818:Animals; D000906:Antibodies; D001798:Blood Proteins; D001853:Bone Marrow / Q000378:metabolism; D001854:Bone Marrow Cells; D004920:Erythropoiesis / Q000187:drug effects*; D004921:Erythropoietin / Q000032:analysis / Q000276:immunology; D005260:Female; D006041:Goats / Q000276:immunology; D006418:Heme / Q000096:biosynthesis; D006801:Humans; D007223:Infant; D007504:Iron Radioisotopes; D008297:Male; D051379:Mice; D009500:Neutralization Tests; D011817:Rabbits / Q000276:immunology; D051381:Rats
D000906:Antibodies; D001798:Blood Proteins; D007504:Iron Radioisotopes; D004921:Erythropoietin; D006418:Heme