Persistent hypotension and intestinal infarction in a patient with primary amyloidosis.
A patient with primary amyloidosis and the nephrotic syndrome had diarrhea and gastrointestinal bleeding probably due to intestinal ischemia. He died with extensive intestinal infarction. The infarction was most likely caused by decreased splanchnic perfusion secondary to the chronic hypotension of the nephrotic syndrome and to amyloid deposition within the walls of the small blood vessels supplying the gut. Although amyloidosis was suspected prior to death, a fixation artifact probably prevented the correct antemortem biopsy diagnosis.
D000368:Aged; D000686:Amyloidosis / Q000150:complications* / Q000175:diagnosis / Q000473:pathology; D003937:Diagnosis, Differential; D006801:Humans; D007022:Hypotension / Q000209:etiology* / Q000473:pathology; D007238:Infarction / Q000209:etiology*; D007413:Intestinal Mucosa / Q000473:pathology; D007422:Intestines / Q000098:blood supply*; D007511:Ischemia / Q000209:etiology / Q000473:pathology; D008297:Male; D009404:Nephrotic Syndrome / Q000150:complications; D012812:Sigmoidoscopy