Enhancement of picrotoxin convulsions in chicks and mice by the prior intraperitoneal injection of hypertonic GABA or mannitol.
Effects of i.p. injection of hypertonic solutions of GABA and mannitol on convulsant activity and latency to reduced or enhanced depending on whether picrotoxin was given i.p. or given i.v. or s.c. The principal cause of these changes appeared to be altered rates of absorption of picrotoxin. There was no evidence that cerebral dehydration afforded protection against picrotoxin.
D000613:Aminobutyrates / Q000494:pharmacology*; D000818:Animals; D000831:Animals, Newborn; D002645:Chickens; D004357:Drug Synergism; D006982:Hypertonic Solutions; D007274:Injections, Intraperitoneal; D008353:Mannitol / Q000008:administration & dosage / Q000494:pharmacology*; D051379:Mice; D008815:Mice, Inbred Strains; D010852:Picrotoxin / Q000494:pharmacology*; D012640:Seizures / Q000139:chemically induced*; D013997:Time Factors; D005680:gamma-Aminobutyric Acid / Q000008:administration & dosage / Q000494:pharmacology*
D000613:Aminobutyrates; D006982:Hypertonic Solutions; D008353:Mannitol; D010852:Picrotoxin; D005680:gamma-Aminobutyric Acid