Immediate oophorectomy and adrenalectomy in the treatment of stage III breast carcinoma. A ten year follow-up study.
One hundred twenty-two patients with state III breast carcinoma had radical mastectomy with or without adjunctive radiation therapy, chemotherapy, or steroids. Thirteen randomly selected persons in the group had immediate bilateral oophoroadrenalectomy. Survival ranged from 10 to 147 months (median, 68.0) with seven of thirteen patients (53.8 per cent) alive five years and three of thirteen (23.0 per cent) alive ten year or longer. No statistical difference in survival or disease-free intervals with respect to menopausal status was observed in the nine patients of this group who died. One hundred and nine patients treated by conventional therapy without endocrine ablation had shorter five year (37.6 per cent) and ten year (15.6 per cent) survival intervals. The difference in survival intervals was statistically significant at p smaller than 0.01. This study suggests that immediate endocrine ablation may prolong survival in patients with stage III breast carcinoma.
D000315:Adrenalectomy; D000328:Adult; D000368:Aged; D000970:Antineoplastic Agents / Q000627:therapeutic use; D001943:Breast Neoplasms / Q000532:radiotherapy / Q000601:surgery / Q000628:therapy*; D002277:Carcinoma / Q000628:therapy*; D002369:Castration; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008408:Mastectomy; D008875:Middle Aged; D010053:Ovary / Q000601:surgery*
D000970:Antineoplastic Agents