title: Teratogenicities of ophthalmic drugs. II. Teratogenicities and tissue accumulation of thimerosal.
abstract: Under the conditions of this study, systemically or topically applied thimerosal was found to have no teratogenic effect even when given in concentrations approaching the 50% lethal dose of these compounds. A comparison of topical and subcutaneous administration of thimerosal to rabbits shows that a substantial concentration of mercury was present in blood and tissues of the treated animals and their offspring. Thimerosal was found to cross the blood-brain and placenta barriers.
mesh_terms: D000287:Administration, Topical; D000818:Animals; D001345:Autoradiography; D001565:Benzoates / Q000008:administration & dosage / Q000378:metabolism / Q000494:pharmacology; D001921:Brain / Q000378:metabolism; D003315:Cornea / Q000378:metabolism; D005035:Ethylmercury Compounds / Q000008:administration & dosage / Q000378:metabolism / Q000494:pharmacology*; D005260:Female; D005865:Gestational Age; D007274:Injections, Intraperitoneal; D007498:Iris / Q000378:metabolism; D007668:Kidney / Q000378:metabolism; D008431:Maternal-Fetal Exchange; D008628:Mercury; D051379:Mice; D009883:Ophthalmic Solutions / Q000009:adverse effects*; D011247:Pregnancy; D011817:Rabbits; D011868:Radioisotopes; D051381:Rats; D013054:Spectrophotometry, Atomic; D013440:Sulfides / Q000008:administration & dosage / Q000378:metabolism / Q000494:pharmacology; D013723:Teratogens
chemical_list: D001565:Benzoates; D005035:Ethylmercury Compounds; D009883:Ophthalmic Solutions; D011868:Radioisotopes; D013440:Sulfides; D013723:Teratogens; D008628:Mercury