A technique for intensifying BCG sensitivity.
Sensitization to BCG (Bacille Calmette-Guérin) appears to be more effective when it is carried out at the site of a delayed hypersensitivity challenge reaction to DNCB (1-chloro, 2,4-dinitrobenzene) than when it is carried out at unchallenged sites in non-sensitized animals. The effectiveness of BCG sensitization was determined by measurement of the intensity of the PPD (Purified Protein Derivative of tuberculin) 24-hour skin test. Possible mechanisms for this phenomenon and its implications for cancer immunotherapy are considered.
D000818:Animals; D001500:BCG Vaccine; D004137:Dinitrochlorobenzene / Q000276:immunology*; D006168:Guinea Pigs; D006968:Hypersensitivity, Delayed; D007111:Immunity, Cellular; D007167:Immunotherapy; D009163:Mycobacterium bovis / Q000276:immunology*; D009369:Neoplasms / Q000276:immunology / Q000628:therapy; D009578:Nitrobenzenes / Q000276:immunology*; D014374:Tuberculin Test
D001500:BCG Vaccine; D004137:Dinitrochlorobenzene; D009578:Nitrobenzenes