Chemotherapy of advanced renal cell carcinoma with vinblastine and CCNU.
Forty-four patients with advanced renal cell carcinoma (stage IV) were divided into 3 groups. The 23 patients in group 1 received CCNU alone,the 6 patients in group 2 received CCNU and vinblastine and the 15 patients in group 3 received methyl CCNU and vinblastine. The over-all response, subjective and objective, was 30% in group 1, 60% in group 2 and 54% in group 3. These results are compared to other existing modalities of treatment and appear to be superior.
D000230:Adenocarcinoma / Q000188:drug therapy* / Q000473:pathology; D000328:Adult; D000368:Aged; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D003510:Cyclohexanes / Q000627:therapeutic use; D004359:Drug Therapy, Combination; D006801:Humans; D007680:Kidney Neoplasms / Q000188:drug therapy* / Q000473:pathology; D008875:Middle Aged; D009588:Nitrogen Mustard Compounds / Q000627:therapeutic use*; D009607:Nitrosourea Compounds / Q000627:therapeutic use*; D014747:Vinblastine / Q000008:administration & dosage
D000970:Antineoplastic Agents; D003510:Cyclohexanes; D009588:Nitrogen Mustard Compounds; D009607:Nitrosourea Compounds; D014747:Vinblastine