Prevention of experimental obstructions in the retinal microcirculation. Arterial Fluorescein Studies.
Platelet aggregates were formed in flowing blood by infusing ADP in the carotid artery of the dog. Under fluorographic examination, these aggregates were seen to lodge in retina vessels. Previous administration of gliclazide helped maintain normal retina circulation.
D000244:Adenosine Diphosphate / Q000494:pharmacology; D000818:Animals; D001792:Blood Platelets / Q000187:drug effects; D004285:Dogs; D005451:Fluorescein Angiography; D005452:Fluoresceins; D008833:Microcirculation / Q000187:drug effects*; D012161:Retinal Artery / Q000187:drug effects*; D013997:Time Factors; D014044:Tolbutamide / Q000494:pharmacology*; D014105:Tosyl Compounds / Q000494:pharmacology*
D005452:Fluoresceins; D014105:Tosyl Compounds; D000244:Adenosine Diphosphate; D014044:Tolbutamide