[Sequential chemotherapy based on the hypothesis of a circadian rhythm of tumor proliferation].
The authors treated 41 cases of advanced solid tumors by a combination chemotherapy with methotrexate, vinblastine and cyclophosphamide administered in a sequential manner according to the hypothesis of a circadiam rhythm of proliferation of human neoplasia. A tumoral regression was observed in 66. 6 p. cent of adenocarcinomas and 86.2 p.cent of non glandular carcinomas.
D000230:Adenocarcinoma / Q000188:drug therapy; D000328:Adult; D000368:Aged; D000970:Antineoplastic Agents / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D002277:Carcinoma / Q000188:drug therapy; D002294:Carcinoma, Squamous Cell / Q000188:drug therapy; D002940:Circadian Rhythm; D002986:Clinical Trials as Topic; D003520:Cyclophosphamide / Q000627:therapeutic use; D004334:Drug Administration Schedule; D004359:Drug Therapy, Combination; D005260:Female; D005472:Fluorouracil / Q000627:therapeutic use; D006098:Granulocytes / Q000187:drug effects; D006801:Humans; D008297:Male; D008727:Methotrexate / Q000627:therapeutic use; D008875:Middle Aged; D008938:Mitosis / Q000187:drug effects; D009362:Neoplasm Metastasis; D009369:Neoplasms / Q000188:drug therapy* / Q000503:physiopathology; D012075:Remission, Spontaneous; D014747:Vinblastine / Q000627:therapeutic use
D000970:Antineoplastic Agents; D014747:Vinblastine; D003520:Cyclophosphamide; D005472:Fluorouracil; D008727:Methotrexate
Chimiothérapie séquentielle basée sur l'hypothèse d'un rhythme circadien de la prolifération tumorale