title: Toxicity of aerosol propellants in the respiratory and circulatory systems. VIII. Respiration and circulation in primates.
abstract: The low-pressure propellants influence predominantly the circulation, whereas the high pressure propellants affect the respiration in anesthetized monkeys. There are four groups according to the level of toxicity: Class 1, low-pressure propellants of high toxicity that cause tachycardia and hypotension; Class 2, low-pressure propellants of intermediate toxicity that influence either circulation or respiration or both; Class 3, high-pressure propellants of intermediate toxicity that cause bronchoconstriction; and Class 4, high-pressure propellants of low toxicity that do not influence respiration or circulation even when inhaled at levels of up to 20 percent concentration.
mesh_terms: D000335:Aerosol Propellants / Q000633:toxicity*; D000336:Aerosols / Q000633:toxicity*; D000818:Animals; D001775:Blood Circulation / Q000187:drug effects*; D006339:Heart Rate / Q000187:drug effects; D006845:Hydrocarbons, Fluorinated / Q000633:toxicity*; D008170:Lung Compliance / Q000187:drug effects; D008253:Macaca mulatta; D011312:Pressure; D012119:Respiration / Q000187:drug effects*; D013696:Temperature; D014132:Trachea / Q000503:physiopathology; D014690:Venous Pressure / Q000187:drug effects
chemical_list: D000335:Aerosol Propellants; D000336:Aerosols; D006845:Hydrocarbons, Fluorinated