Washed hyperpacked frozen and shelf red blood cells.
In order to determine the maximum degree to which blood units could be packed and still be effective, shelf stored blood and previously frozen red blood cells were washed and hyperpacked to hematocrits of 90 to 98 per cent. These products had average volumes of 180 and 162 ml, respectively. When transfused into a group of patients with stable nonhemolytic anemias or with slow or intermittent blood loss, the hyperpacked shelf stored blood resulted in average hematocrit increments of 4.4 per cent; the hyperpacked frozen red blood cells resulted in average hematocrit increments of 3.4 per cent. Conventionally packed unwashed red blood cells had approximately 10 per cent more hemoglobin and volumes of 270 to 330 ml, but resulted in average hematocrit elevations of only 2.8 per cent. Unwashed blood hyperpacked to hematocrits of 90 per cent with removal of the visible buffy coat took much longer to administer. Thus, by washing and hyperpacking shelf stored blood or previously forzen red blood cells, transfusions with the minimal amount of extraneous material can be given.
D001793:Blood Preservation / Q000379:methods*; D001803:Blood Transfusion; D002498:Centrifugation; D002951:Citrates; D004912:Erythrocytes; D005615:Freezing; D005947:Glucose; D006400:Hematocrit; D006801:Humans; D010710:Phosphates
D002951:Citrates; D010710:Phosphates; D005947:Glucose