Antiprostatic effects of a nitrogen mustard of estriol.
The chemical ester of a nitrogen mustard with estriol was tested for its antiprostatic effects in dogs and rats.  The E33-mustard was shown to interfere with the uptake of labeled estriol in the dog prostate and by the ventral prostate of the rat; and to increase the uptake of the radioactivity associated with testosterone in the dog prostate.  The weights of the ventral and dorsolateral prostates of the rat were significantly reduced following the administration of E3-mustard for 2 days.  The results are interpreted to be very similar to those obtained with the mustard of E (Estracyt) and the effects are probably a combination of the actions of the released estrogen (D) and/or mustard, either adding individually or in concert.
D000818:Animals; D002369:Castration; D004285:Dogs; D004338:Drug Combinations; D004961:Estramustine / Q000627:therapeutic use*; D004964:Estriol / Q000378:metabolism / Q000494:pharmacology; D008297:Male; D009588:Nitrogen Mustard Compounds / Q000494:pharmacology / Q000627:therapeutic use*; D009929:Organ Size; D011467:Prostate / Q000033:anatomy & histology / Q000187:drug effects / Q000378:metabolism; D011471:Prostatic Neoplasms / Q000188:drug therapy*; D051381:Rats; D013739:Testosterone / Q000378:metabolism / Q000627:therapeutic use; D014316:Tritium
D004338:Drug Combinations; D009588:Nitrogen Mustard Compounds; D014316:Tritium; D004961:Estramustine; D013739:Testosterone; D004964:Estriol