title: Neurofibrillary accumulation in a puppy.
abstract: A diffuse neuronal intracytoplasmic accumulation of a fibrillar material is described in a 12-week-old puppy with signs of progressive neurologic disease. Electron microscopic examination revealed fibrils about 120A in diameter aggregated in the perikaryon and processes of neurons primarily in the brain stem.
mesh_terms: D000818:Animals; D001927:Brain Diseases / Q000473:pathology / Q000662:veterinary*; D001933:Brain Stem / Q000473:pathology; D004283:Dog Diseases / Q000473:pathology*; D004285:Dogs; D008526:Medulla Oblongata / Q000648:ultrastructure; D008636:Mesencephalon / Q000473:pathology; D009454:Neurofibrils / Q000648:ultrastructure*; D009474:Neurons / Q000473:pathology / Q000648:ultrastructure; D012160:Retina / Q000648:ultrastructure; D013788:Thalamus / Q000648:ultrastructure