Effect of antimyeloma cell antiserum on immunological enhancement.
Growth of Sarvoma 180 in AKR mice was enhanced by immunization with frozen-thawed homogenates of this tumor. Treatment of host mice with rabbit antimyeloma cell antiserum, either furing immunization or shortly after tumor implantation, resulted in a decreased incidence of tumor rejection or an increased rate of tumor growth. A slow-growing subline from a spontaneous, DBA/2Ha-DD mammary tumor is rejected after initial growth in DBA/2J mice. The incidence of rejection was reduced by treatment with the antiserum studied.
D000818:Animals; D002460:Cell Line; D005260:Female; D006084:Graft Rejection; D007106:Immune Sera; D007108:Immune Tolerance; D007114:Immunization; D007165:Immunosuppression Therapy; D008325:Mammary Neoplasms, Experimental / Q000276:immunology; D051379:Mice; D008806:Mice, Inbred AKR; D008807:Mice, Inbred BALB C; D008811:Mice, Inbred DBA; D010954:Plasmacytoma / Q000276:immunology*; D011817:Rabbits / Q000276:immunology; D012510:Sarcoma 180 / Q000276:immunology*; D013997:Time Factors
D007106:Immune Sera