[Action of antibiotic 1719 from a group of diazo compounds on hematopoiesis in laboratory animals and its pharmacokinetics].
Antibiotic 1719 administered intravenously to rats in a single dose of 6.0 mg/kg induced a transitory decrease in the number of myelocariocytes on the 2nd-5th day of its use mainly at the account of decreased numbers of lymphoid elements. Simultaneously momentory leucopenia (granulocytopenia) and more stable lymphopenia were observed. When the antibiotic was administered intravenously to dogs in a dose of 0.9 mg/kg 4 times and in a dose of 0.4 mg/kg 40 times, an insignificant decrease in the number of myelocarlocytes was noted. Leucopenia, lymphopenia and thrombocytopenia in the peripheral blood almost completely disappeared after discontinuation of the preparation administration. Leucocytosis (granulocytosis), lymphopenia and thrombocytopenia were registered in the dogs and rabbits treated with the antibiotic in doses of 1.5 and 3.0 mg/kg 3 and 11 times respectively. When the antibiotic was added to the rabbit blood serum in concentrations of 0.5-5 gamma/ml, 70 to 80 per cent of the preparation bound with the blood proteins. After a single intravenous administration of antibiotic 1719 to rabbits in doses of 10 and 15 mg/kg, it was detected in the blood only for 5 to 15 minutes after the administration in concentrations not exceeding 0.3 and 0.5 gamma/ml. The antibiotic penetrated into all organs in small amounts and persisted there for 1.5 to 3 hours after the administration. The antibiotic was excreted with the bile in amounts of 0.3-0.5 per cent of the dose administered for 1 to 2 hours after a single administration. The antibiotic was excreted with the urine for 3-4 hours after the administration in amounts of 3.5 per cent after a single administration and 60-72 per cent after multiple administrations.
D000818:Animals; D000900:Anti-Bacterial Agents / Q000032:analysis / Q000494:pharmacology*; D001391:Azo Compounds / Q000032:analysis / Q000494:pharmacology*; D001853:Bone Marrow / Q000187:drug effects; D001854:Bone Marrow Cells; D004285:Dogs; D004305:Dose-Response Relationship, Drug; D005609:Free Radicals; D006410:Hematopoiesis / Q000187:drug effects*; D007275:Injections, Intravenous; D007700:Kinetics; D007964:Leukocytosis / Q000139:chemically induced; D007970:Leukopenia / Q000139:chemically induced; D011485:Protein Binding / Q000187:drug effects; D011817:Rabbits; D051381:Rats; D013921:Thrombocytopenia / Q000139:chemically induced; D013997:Time Factors
D000900:Anti-Bacterial Agents; D001391:Azo Compounds; D005609:Free Radicals
Deĭstvie antibiotika 1719 iz gruppy diazosoedineniĭ na krovetvorenie laboratornykh zhivotnykh i ego farmakokinetika