Two cases of acute pandysautonomia.
Two men had acute nonprogressive pandysautonomia. Both of them showed orthostatic hypotension, fainting in upright position, pupillary disturbances, diminished sweating, anacidity, and impotence. Case 1 showed considerable but inadequate improvement within 31 months. Case 2 recovered completely after 11 months. Clinical and pharmacodynamic investigations suggested that the main lesion was located in postganglionic fibers in case 1 and in preganglionic fibers in case 2. The cause of this disorder is unknown, although both patients had undergone substantial weight loss.
D000109:Acetylcholine / Q000494:pharmacology; D000208:Acute Disease; D000328:Adult; D001341:Autonomic Nervous System; D001794:Blood Pressure / Q000187:drug effects; D003042:Cocaine / Q000494:pharmacology; D004299:Dopamine beta-Hydroxylase / Q000097:blood; D004809:Ephedrine / Q000494:pharmacology; D004837:Epinephrine / Q000494:pharmacology; D006358:Hot Temperature; D006801:Humans; D007003:Hypoglycemia / Q000139:chemically induced; D007328:Insulin; D008297:Male; D008688:Methacholine Compounds / Q000494:pharmacology; D008875:Middle Aged; D009422:Nervous System Diseases / Q000201:enzymology / Q000503:physiopathology; D010862:Pilocarpine / Q000494:pharmacology; D010863:Piloerection / Q000187:drug effects; D011674:Pulse / Q000187:drug effects; D011680:Pupil / Q000187:drug effects; D013546:Sweating / Q000187:drug effects; D013566:Sympathomimetics / Q000494:pharmacology
D007328:Insulin; D008688:Methacholine Compounds; D013566:Sympathomimetics; D010862:Pilocarpine; D004299:Dopamine beta-Hydroxylase; D004809:Ephedrine; D003042:Cocaine; D000109:Acetylcholine; D004837:Epinephrine