title: Topical 5-fluorouracil in the treatment of carcinoma in situ of the vulva.
abstract: The clinical and pathologic response of carcinoma in situ of the vulva in a 42-year-old woman treated with topical 5-fluorouracil is reported. Except for one persistent area of involvement in the anal region which required local excision, the result of treatment was excellent, with no evidence of recurrence after 2 years' followup. This important adjunct in the treatment of intra-epithelial carcinoma deserves long-range investigation.
mesh_terms: D000287:Administration, Topical; D000328:Adult; D002278:Carcinoma in Situ / Q000188:drug therapy*; D002294:Carcinoma, Squamous Cell / Q000188:drug therapy*; D005260:Female; D005472:Fluorouracil / Q000008:administration & dosage / Q000627:therapeutic use*; D006801:Humans; D014846:Vulvar Neoplasms / Q000188:drug therapy*
chemical_list: D005472:Fluorouracil