[Inhibition by somatostatin of pancreatic juice and enzyme secretion and gallbladder contraction in man induced by secretin and cholecystokinin-pancreozymin administration (author's transl)].
Somatostatin (200 mug/h) was administered to five healthy volunteers after submaximal stimulation of exocrine pancreatic secretion with 0.33 KU secretin or cholecystokinin-pancreozymin, given intravenously. In all instances there was a significant reduction in duodenal secretory volume after secretin, without any change in HCO3- concentration. Stimulation of enzyme secretion by cholecystokinin-pancreozymin was significantly inhibited and gallbladder contraction abolished.
D000328:Adult; D000681:Amylases / Q000032:analysis; D001639:Bicarbonates / Q000032:analysis; D002766:Cholecystokinin / Q000494:pharmacology*; D004386:Duodenum; D005704:Gallbladder / Q000187:drug effects*; D006801:Humans; D007419:Intestinal Secretions / Q000032:analysis / Q000201:enzymology; D008297:Male; D010179:Pancreas / Q000187:drug effects* / Q000378:metabolism; D012633:Secretin / Q000494:pharmacology*; D013004:Somatostatin / Q000494:pharmacology*; D014357:Trypsin / Q000032:analysis
D001639:Bicarbonates; D012633:Secretin; D013004:Somatostatin; D002766:Cholecystokinin; D000681:Amylases; D014357:Trypsin
Hemmung der Sekretin-und Cholezystokinin-Pankreozymin-induzierten Saft-und Enzymsekretion des Pankreas und der Gallenblasenkontraktion beim Menschen durch Somatostatin