Time-dependent changes in amphetamine self-administration following frontal cortex ablations in rats.
Rats were trained to intravenously self-administer d-amphetamine (.01 mg/kg/reward infusion) during daily 1-hr. testing sessions. Following removal of frontal cortex, rates of d-amphetamine self-administration were higher at early (3-5 days) postoperative intervals but lower at later (2-4 wk.) postoperative intervals. These and other results indicated that, as a function of time after surgery, frontal rats are first hyposensitive and then become increasingly hypersensitive to the rewarding effect of d-amphetamine.
D000818:Animals; D002540:Cerebral Cortex / Q000502:physiology*; D003214:Conditioning, Classical / Q000187:drug effects; D003913:Dextroamphetamine / Q000008:administration & dosage* / Q000494:pharmacology; D005260:Female; D007275:Injections, Intravenous; D051381:Rats; D013997:Time Factors
D003913:Dextroamphetamine