Teratogenicities of ophthalmic drugs. II. Teratogenicities and tissue accumulation of thimerosal.
Under the conditions of this study, systemically or topically applied thimerosal was found to have no teratogenic effect even when given in concentrations approaching the 50% lethal dose of these compounds. A comparison of topical and subcutaneous administration of thimerosal to rabbits shows that a substantial concentration of mercury was present in blood and tissues of the treated animals and their offspring. Thimerosal was found to cross the blood-brain and placenta barriers.
D000287:Administration, Topical; D000818:Animals; D001345:Autoradiography; D001565:Benzoates / Q000008:administration & dosage / Q000378:metabolism / Q000494:pharmacology; D001921:Brain / Q000378:metabolism; D003315:Cornea / Q000378:metabolism; D005035:Ethylmercury Compounds / Q000008:administration & dosage / Q000378:metabolism / Q000494:pharmacology*; D005260:Female; D005865:Gestational Age; D007274:Injections, Intraperitoneal; D007498:Iris / Q000378:metabolism; D007668:Kidney / Q000378:metabolism; D008431:Maternal-Fetal Exchange; D008628:Mercury; D051379:Mice; D009883:Ophthalmic Solutions / Q000009:adverse effects*; D011247:Pregnancy; D011817:Rabbits; D011868:Radioisotopes; D051381:Rats; D013054:Spectrophotometry, Atomic; D013440:Sulfides / Q000008:administration & dosage / Q000378:metabolism / Q000494:pharmacology; D013723:Teratogens
D001565:Benzoates; D005035:Ethylmercury Compounds; D009883:Ophthalmic Solutions; D011868:Radioisotopes; D013440:Sulfides; D013723:Teratogens; D008628:Mercury