Stoichiometric inhibition of mammalian dihydrofolate reductase by the gamma-glutamyl metabolite of methotrexiate, 4-amino-4-deoxy-N-10-methylpteroylglutamyl-gamma-glutamate.
D000818:Animals; D002455:Cell Division / Q000187:drug effects; D002478:Cells, Cultured; D002850:Chromatography, Gel; D004305:Dose-Response Relationship, Drug; D005493:Folic Acid Antagonists; D005971:Glutamates; D007939:Leukemia L1210 / Q000201:enzymology; D008727:Methotrexate / Q000031:analogs & derivatives* / Q000494:pharmacology; D051379:Mice; D013329:Structure-Activity Relationship
D005493:Folic Acid Antagonists; D005971:Glutamates; D008727:Methotrexate