title: DNA repair in tumor cells from the variant form of xeroderma pigmentosum.
abstract: Cells from most patients with xeroderma pigmentosum (XP) can be shown to be defective in repairing ultraviolet (UV) light-induced damage to their DNA, for they have a reduced rate of UV-induced thymidine incorporation.  XP variants, however, have clinical manifestations of XP, but all their tissues tested to date have a normal rate of UV-induced 3H-thymidine incorporation. We have now tested tumor cells from an XP variant and from a typical XP patient.  The variant's tumor cells, in contrast to those of the typical patient, had no detectable defect in their UV-induced thymidine corporation.  We conclude, therefore, that the cells that formed tumors in this XP variant resemble his other cells in DNA repair capacity, and do not represent a minor cell population with the kind of DNA repair defect that is reflected in reduced UV-induced thymidine incorporation.
mesh_terms: D001345:Autoradiography; D002280:Basal Cell Carcinoma / Q000378:metabolism*; D002478:Cells, Cultured; D004247:DNA / Q000528:radiation effects*; D004260:DNA Repair; D006801:Humans; D011830:Radiation Effects; D012878:Skin Neoplasms / Q000378:metabolism*; D013936:Thymidine / Q000378:metabolism; D014316:Tritium; D014466:Ultraviolet Rays; D014983:Xeroderma Pigmentosum / Q000378:metabolism*
chemical_list: D014316:Tritium; D004247:DNA; D013936:Thymidine