Para-O-methylation of the catecholamines in neuroblastoma.
By means of thin-layer chromatographic methods, iso-homovanillic acid (iso-HVA), iso-vanillactic acid (iso-VLA) and iso-vanilmandelic acid (iso-VMA) were determined in the urine of 10 children with neuroblastoma. The mean excretion of iso-HVA was 10.1% of total HVA excretion. Three patients excreted VLA; in their urine no iso-VLA was detected with certainty. All patients excreted high amounts of VMA; there was no detectable excretion of iso-VMA. Those results suggest that para-O-methylation could be limited to dopamine catabolism.
D002395:Catecholamines / Q000378:metabolism*; D002648:Child; D002855:Chromatography, Thin Layer; D006719:Homovanillic Acid / Q000031:analogs & derivatives / Q000652:urine; D006801:Humans; D007773:Lactates / Q000652:urine; D009447:Neuroblastoma / Q000378:metabolism* / Q000652:urine; D014641:Vanillic Acid / Q000652:urine; D014642:Vanilmandelic Acid / Q000031:analogs & derivatives / Q000652:urine
D002395:Catecholamines; D007773:Lactates; D014642:Vanilmandelic Acid; D014641:Vanillic Acid; D006719:Homovanillic Acid