Treatment of respiratory Klebsiella pneumoniae infection in mice with aerosols of kanamycin.
Aerosols of kanamycin resulted in greater survival of mice challenged with respiratory Klebsiella pneumoniae than the same dosage given intramuscularly. Determinations of viable bacteria in the blood and lungs revealed that aerosolized kanamycin was most effective when infection was confined to the lungs. After the organisms had spread to other areas, however, aerosol therapy was still more effective than intramuscular therapy, but only one-half the infected mice survived.
D000336:Aerosols; D000818:Animals; D005260:Female; D007273:Injections, Intramuscular; D007612:Kanamycin / Q000008:administration & dosage / Q000627:therapeutic use*; D007710:Klebsiella Infections / Q000188:drug therapy*; D007711:Klebsiella pneumoniae; D051379:Mice; D008813:Mice, Inbred ICR; D010316:Particle Size; D011014:Pneumonia / Q000188:drug therapy*; D013997:Time Factors
D000336:Aerosols; D007612:Kanamycin