[Possibility of the occurrence of the Shwartzman phenomenon during administration of a reacting dose of typhoid antigen through the respiratory tracts].
This work is devoted to the study of possible vaccinal complications of Schwartzmann's phenomenon type following subcutaneous injection to rabbits, sensitized by typhoid antigen, of a reacting dose of the same antigen through the respiratory tracts. The reacting dose of the antigen of 0.5; 1.0, 1.5 ml was injected to the rabbits in the form of a dry and liquid aerosol intratracheally intrapulmonary and subcutaneously. Animals to which the reacting dose of the same antigen (0.1; 0.25; 0.5; 1.0 mg) was injected intravenously served as control. Local Schwartzmann's phenomenon was reproduced after administration of all the reacting doses of typhoid antigen tested by intravenous method only. Administration of the reacting dose of the same antigen through the respiratory tracts failed to produce local Schwartzmann's phenomenon, this pointing to the difference in the reaction of rabbit organism sensitized with typhoid antigen to the administration of a reacting dose of the same antigen through the respiratory tracts, in comparison with the intravenous method.
D000336:Aerosols; D000818:Animals; D000942:Antigens, Bacterial / Q000008:administration & dosage*; D007114:Immunization / Q000009:adverse effects*; D007275:Injections, Intravenous; D007279:Injections, Subcutaneous; D008168:Lung; D008297:Male; D011817:Rabbits; D012485:Salmonella typhi / Q000276:immunology*; D012790:Shwartzman Phenomenon / Q000209:etiology*; D014132:Trachea
D000336:Aerosols; D000942:Antigens, Bacterial
O veroiatnosti vozniknoveniia fenomena Shvartzmana pri vvedenii razreshaiushcheĭ dozy briushnotifoznogo antigena cherez dykhatel'nye puti