[Effect of carbenicillin and its combination with prodigiozan and lysozyme on the course of an experimental inflammatory process of Proteus etiology].
Biological properties of 142 Proteus strains isolated from patients were studied. Sensitivity of Proteus to II antibiotics was tested. The isolates were resistant to most of the antibiotics. The highest number of the isolates was sensitive to ampicillin (77.1 minus or plus 7.16) and especially to carbenicillin (82.6 plus or minus 6.16). This provided the use of carbenicillin for the treatment of experimental septicemia in albino mice and wound processes in rabbits with Proteus complications. The high therapeutic effect of the antibiotic was shown in experiments with 210 albino mice and 44 rabbits. The therapeutic effect of carbenicillin increased when it was used in combination with prodigiozan and especially in combination with prodigiozan and lysozyme.
D000818:Animals; D002228:Carbenicillin / Q000627:therapeutic use*; D004357:Drug Synergism; D004359:Drug Therapy, Combination; D007274:Injections, Intraperitoneal; D051379:Mice; D008826:Microbial Sensitivity Tests; D009113:Muramidase / Q000627:therapeutic use*; D011353:Prodigiosin / Q000627:therapeutic use*; D011511:Proteus / Q000187:drug effects / Q000302:isolation & purification; D011512:Proteus Infections / Q000188:drug therapy* / Q000382:microbiology; D011817:Rabbits; D018805:Sepsis / Q000382:microbiology; D013997:Time Factors
D009113:Muramidase; D002228:Carbenicillin; D011353:Prodigiosin
Vliianie karbenitsillina i ego sochetaniia s prodigiozanom i lizotsimom na techenie vospalitel'nogo protsessa proteĭnoĭ étiologii v éksperimente