Influence of energy metabolism on the repair of x-ray damage in living cells. IV. Effects of 2-deoxy-D-glucose on the repair phenomena during fractionated irradiation of yeast.
Inhibition of repair of sublethal and potentially lethal damage was observed in respiratory-deficient mutants of yeast during fractionated X-irradiation in the presence of equimolar concentrations of 2-deoxy-D-glucose and glucose in the growth medium. In the wild-type cells, on the other hand, an enhancement of repair of the potentially lethal damage was obtained under similar conditions. These results suggest, by analogy, that in higher organisms also, 2-deoxy-D-glucose may differentially inhibit the repair of radiation damage in hypoxic tumor cells while enhancement of repair processes could be expected in normal tissues.
D004260:DNA Repair / Q000187:drug effects*; D003837:Deoxy Sugars / Q000494:pharmacology*; D003847:Deoxyglucose / Q000494:pharmacology* / Q000627:therapeutic use; D004307:Dose-Response Relationship, Radiation; D009154:Mutation; D009369:Neoplasms / Q000532:radiotherapy; D010100:Oxygen; D011831:Radiation Genetics; D011838:Radiation-Sensitizing Agents / Q000627:therapeutic use; D012441:Saccharomyces cerevisiae / Q000528:radiation effects*; D014965:X-Rays
D003837:Deoxy Sugars; D011838:Radiation-Sensitizing Agents; D003847:Deoxyglucose; D010100:Oxygen