[The hemodynamic effect of verapamil by intravenous administration in middle-aged, subjectively healthy subjects at rest and during exercise].
After an intravenous injection of 0.1 mg Verapamil per kg body weight and during an infusion of 0.007 mg Verapamil per kg body weight and minute the heart rate increased, P,Q,-time increased, pulmonary vascular pressures increased. Aortic pressures decreased. No change in maximum dp/dt of the aortic pressure. The word maximum is still missing. Pre-ejection period decreased. During an exercise on a load of 650 kpm/min on average heart rate after Verapamil was increased, aortic pressures decreased, stroke work decreased and there were no signs of any negative inotropic effect.
D000328:Adult; D000367:Age Factors; D001794:Blood Pressure / Q000187:drug effects; D001824:Body Constitution; D002302:Cardiac Output / Q000187:drug effects; D002306:Cardiac Volume; D005080:Exercise Test; D006339:Heart Rate / Q000187:drug effects; D006439:Hemodynamics / Q000187:drug effects*; D006801:Humans; D008297:Male; D008875:Middle Aged; D005082:Physical Exertion; D014655:Vascular Resistance / Q000187:drug effects; D014700:Verapamil / Q000494:pharmacology*
D014700:Verapamil
Effetto emodinamico del veraa,il per via endovenosa su soggetti di mezza età soggettivamente in buona salute, a riposo e sotto sforzo