Accumulation of 3H-estradiol in the vaginas and pituitary glands of mice of inbred strains.
The sensitivity of the vaginal epithelium of ovariectomized mice of the A and C57 strains to estradiol differ approximately fivefold.  The vaginas of the more sensitive C57 strain did accumulate more 333H-E2 at 1 hr in two or three experiments but the retention at 6 and 12 hr was not significantly different.  The pituitary accumulation of H-E2 by the pituitary-tumor susceptable C57 mice, although not significantly greater than that of the nonsusceptable A strain mice at 1 hr was higher at 6 and 12 hr after the injection.  Most of the toluene extractable radioactivity from pituitary glands and vaginas was estradiol with no strain differences.  The accumulation of H-E2 in other tissues was not significantly different in mice of the two strains.
D000818:Animals; D002369:Castration; D004198:Disease Susceptibility; D004848:Epithelium / Q000378:metabolism; D004958:Estradiol / Q000009:adverse effects / Q000032:analysis / Q000378:metabolism*; D005260:Female; D051379:Mice; D008805:Mice, Inbred A; D008810:Mice, Inbred C57BL; D010902:Pituitary Gland / Q000032:analysis / Q000378:metabolism*; D010911:Pituitary Neoplasms / Q000139:chemically induced; D013997:Time Factors; D014316:Tritium; D014621:Vagina / Q000032:analysis / Q000378:metabolism*
D014316:Tritium; D004958:Estradiol