Failure to detect chromosome damage in vivo in Friend virus-infected leukemic mice.
The cytogenetic activity of Friend virus (FV) was tested in vivo on spleen and bone marrow cells of FV-infected leukemic C3H/HeJ and STS mice. No specific chromosome rearrangements were detected in the infected animals. Some chromosome abnormalities were recorded in both normal and diseased animals; however, aberrations did not significantly increase in the leukemic groups.
D000818:Animals; D001853:Bone Marrow / Q000648:ultrastructure; D001854:Bone Marrow Cells; D002869:Chromosome Aberrations; D005622:Friend murine leukemia virus; D007942:Leukemia, Experimental / Q000209:etiology / Q000235:genetics*; D051379:Mice; D008809:Mice, Inbred C3H; D013154:Spleen / Q000648:ultrastructure