title: [Morphological studies on the hepatotoxic effect of Thiuram (tetramethylthiuram disulphide) in white rats].
abstract: After a single per os or a single and repeated subcutan doses of Thiuram necrosis of the liver of different extension was revealed. Changes could be seen by 3--14 days after administration of Thiuram in different doses. In some cases animals died spontaneously. These investigations seems to evidence the fact that Thiuram, which is similar to Disulphiram (Antaethyl-Antabus) used in the therapy of chronic alkoholism in big doses exerts a noxious effect on the liver of white rats.
mesh_terms: D000818:Animals; D056486:Chemical and Drug Induced Liver Injury / Q000473:pathology*; D004221:Disulfiram / Q000633:toxicity*; D008099:Liver / Q000187:drug effects / Q000473:pathology*; D008103:Liver Cirrhosis / Q000139:chemically induced* / Q000473:pathology; D051381:Rats
chemical_list: D004221:Disulfiram
vernacular_title: Morphologiai megfigyelések a Thiuram-(tetramethyl-thiuram-disulphid) hepatotoxikus hatásáról fehér patkányokban