Lomotil ingestions in children.
Although the incidence of adverse reactions is relatively low in adults, Lomotil may result in serious toxicity in children. Early effects are often due to the atropine present in the compound, while the narcotic-like actions of diphenoxylate HCI tend to occur later. Respiratory depression is the most threatening reaction and should be treated with naloxone.
D001285:Atropine / Q000378:metabolism / Q000506:poisoning*; D001831:Body Temperature / Q000187:drug effects; D002648:Child; D002675:Child, Preschool; D004157:Diphenoxylate / Q000378:metabolism / Q000506:poisoning*; D004338:Drug Combinations; D005260:Female; D006801:Humans; D007223:Infant; D007540:Isonipecotic Acids / Q000506:poisoning*; D008297:Male; D009292:Narcotic Antagonists / Q000627:therapeutic use; D012131:Respiratory Insufficiency / Q000139:chemically induced / Q000188:drug therapy
D004338:Drug Combinations; D007540:Isonipecotic Acids; D009292:Narcotic Antagonists; D004157:Diphenoxylate; D001285:Atropine