Methyoxuflurane and serum fluoride concentrations during anaesthesia and postoperative renal function.
In twenty gynaecological patients scheduled for hysterectomy, arterial blood concentrations of methoxyflurane and fluoride ions were measured during operation. Renal function was assessed by pre and postoperative measurements of BUN, creatinine, osmolality and serum electrolytes. Fluid balances were calculated by the daily intake and output values. During the first five postoperative days, from the 12 hour urine specimens the fluoride concentrations were measured, and from the 24 hour specimens urine electrolytes and creatinine levels were calculated. No clinical or laboratory evidence of renal dysfunction was observed. Fluoride levels were lower than those previously associated with renal toxicity. Methoxyflurane concentrations in arterial blood showed concentrations lower as previously reported.
D000328:Adult; D000368:Aged; D000768:Anesthesia, General; D000773:Anesthesia, Obstetrical; D001794:Blood Pressure; D003404:Creatinine / Q000652:urine; D005260:Female; D005459:Fluorides / Q000097:blood* / Q000652:urine; D006801:Humans; D007044:Hysterectomy; D007668:Kidney / Q000187:drug effects*; D008657:Metabolic Clearance Rate; D008733:Methoxyflurane / Q000009:adverse effects / Q000097:blood / Q000378:metabolism*; D008875:Middle Aged; D009994:Osmolar Concentration; D013997:Time Factors; D014882:Water-Electrolyte Balance
D008733:Methoxyflurane; D003404:Creatinine; D005459:Fluorides