title: The role of immune pig colostrum, serum and immunoglobulins IgG, IgM, and IgA, in local intestinal immunity against enterotoxic strain in Escherichia coli O55 in germfree piglets.
abstract: The protective effect of pig immune colostrum, serum and immunoglobulins IgG, IgM and IgA against the enterotoxic strain of Escherichia coli O55, was studied in newborn germfree piglets. This strain produced accumulation of fluid and dilatation of intestine when injected into the ligated ileal segment of germfree piglets, which is considered to be the typical effect of enterotoxins. Erosion of the intestinal epithelium and penetration of bacteria into the submucosa were also observed. Immune serum, colostrum and all the immunoglobulin classes used produced a local protective effect, IgA being most effective. The mechanism of protection conferred by these immunoglobulins is discussed with respect to the possible pathogenic action of enterotoxic Escherichia coli O55 in the intestinal tract of immunologically virgin germfree piglets.
mesh_terms: D000818:Animals; D000831:Animals, Newborn; D003126:Colostrum / Q000276:immunology*; D003967:Diarrhea / Q000209:etiology / Q000276:immunology / Q000517:prevention & control*; D004768:Enterotoxins / Q000096:biosynthesis / Q000633:toxicity; D004926:Escherichia coli / Q000378:metabolism; D004927:Escherichia coli Infections / Q000209:etiology / Q000276:immunology / Q000517:prevention & control*; D005856:Germ-Free Life; D007082:Ileum / Q000276:immunology; D007106:Immune Sera; D007109:Immunity; D007116:Immunization, Passive; D007070:Immunoglobulin A; D007074:Immunoglobulin G; D007075:Immunoglobulin M; D007136:Immunoglobulins; D013552:Swine
chemical_list: D004768:Enterotoxins; D007106:Immune Sera; D007070:Immunoglobulin A; D007074:Immunoglobulin G; D007075:Immunoglobulin M; D007136:Immunoglobulins