[Carcinogenesis due to mustard gas exposure in man, important sign for therapy with alkylating agents].
Sulphur-mustard and nitrogen-mustard are known to act as carcinogens in animal experiments. A similar effect in humans was demonstrated in 245 workers previously exposed occupationally to mustard gas and followed for over 20 years. There was a statistically significant increase in malignant tumours, especially bronchial carcinoma, bladder carcinoma and leukaemia. These findings underline the need for using alkylating agents of the mustard type exclusively in the treatment of malignant neoplasms. Immunosuppression with alkylating agents in the treatment of chronic inflammatory diseases associated with a long life expectancy is no longer justified.
D000328:Adult; D000477:Alkylating Agents / Q000009:adverse effects / Q000627:therapeutic use; D001984:Bronchial Neoplasms / Q000139:chemically induced / Q000453:epidemiology; D002273:Carcinogens; D003095:Collagen Diseases / Q000188:drug therapy; D005860:Germany, West; D006801:Humans; D007165:Immunosuppression Therapy / Q000009:adverse effects; D007938:Leukemia / Q000139:chemically induced / Q000453:epidemiology; D008017:Life Expectancy; D008297:Male; D009150:Mustard Compounds / Q000009:adverse effects*; D009151:Mustard Gas / Q000009:adverse effects*; D009369:Neoplasms / Q000139:chemically induced*; D009784:Occupational Diseases / Q000139:chemically induced*; D009787:Occupational Medicine; D012189:Retrospective Studies; D013223:Statistics as Topic; D001749:Urinary Bladder Neoplasms / Q000139:chemically induced / Q000453:epidemiology
D000477:Alkylating Agents; D002273:Carcinogens; D009150:Mustard Compounds; D009151:Mustard Gas
Karzinogenese durch Lost-Exposition beim Menschen, ein wichtiger Hinweis für die Alkylantien-Therapie