Pituitary and ovarian response patterns to stimulation in the postpartum and in galactorrhea-amenorrhea. The role of prolactin.
In order to assess the action of prolactin on the puerperal pituitary-ovarian resistance to physiologic stimulation, a study was conducted in 27 women divided into three groups. Group I: 9 postpartum women who did not wish to breastfeed their infants and received 2.5 mg bromocriptin (CB 154) twice daily for 14 days starting immediately after delivery; Group II: 9 normally lactating mothers; and Group III: 9 women with hyperprolactinemia associated with amenorrhea. The three groups underwent stimulation with LHRH and Pergonal 500. Results indicate lack of prolactin dependence in the pituitary-ovarian resistance of the puerperium. The possible mechanisms involved in the anovulatory period of lactation are discussed.
D000328:Adult; D000568:Amenorrhea / Q000097:blood / Q000503:physiopathology*; D001942:Breast Feeding; D001971:Bromocriptine / Q000494:pharmacology; D004958:Estradiol / Q000097:blood; D005260:Female; D005640:Follicle Stimulating Hormone / Q000097:blood; D005687:Galactorrhea / Q000097:blood / Q000503:physiopathology*; D007987:Gonadotropin-Releasing Hormone / Q000494:pharmacology; D006801:Humans; D007775:Lactation Disorders / Q000503:physiopathology*; D008596:Menotropins / Q000494:pharmacology; D010053:Ovary / Q000502:physiology* / Q000503:physiopathology; D010902:Pituitary Gland / Q000502:physiology* / Q000503:physiopathology; D049590:Postpartum Period; D011247:Pregnancy; D011388:Prolactin / Q000037:antagonists & inhibitors / Q000097:blood / Q000502:physiology*
D007987:Gonadotropin-Releasing Hormone; D001971:Bromocriptine; D004958:Estradiol; D008596:Menotropins; D011388:Prolactin; D005640:Follicle Stimulating Hormone