The development of kinetic parameters of hepatic drug-metabolizing enzymes in perinatal rats.
The development of the apparent kinetic parameters K-  m and V-max was studied in perinatal Wistar rats for three functionally diverse, hepatic enzymes (p-nitroanisole O-demethylase, carboxylesterase and bromosulphophthalein-glutathione conjugating enzyme), the period studied being from 3 days prepatum to 35 days postpartum. The kinetic parameters underwent marked quantitative changes during development, which appeared to be independent of sex for the first 5 weeks postpartum.
D000375:Aging; D000818:Animals; D000831:Animals, Newborn; D000840:Anisoles; D001835:Body Weight; D004247:DNA / Q000378:metabolism; D004950:Esterases / Q000378:metabolism*; D005260:Female; D005333:Fetus; D005978:Glutathione; D007700:Kinetics; D008025:Ligases / Q000378:metabolism*; D008099:Liver / Q000033:anatomy & histology / Q000254:growth & development / Q000378:metabolism*; D008297:Male; D009929:Organ Size; D010088:Oxidoreductases / Q000378:metabolism*; D011247:Pregnancy; D011506:Proteins / Q000378:metabolism; D012313:RNA / Q000378:metabolism; D051381:Rats; D012737:Sex Factors; D013448:Sulfobromophthalein
D000840:Anisoles; D011506:Proteins; D013448:Sulfobromophthalein; D012313:RNA; D004247:DNA; D010088:Oxidoreductases; D004950:Esterases; D008025:Ligases; D005978:Glutathione