Hyperammonemia due to a urea cycle enzyme deficiency in two dogs.
Hyperammonemia in 2 dogs was associated with a deficiency of arginosuccinate synthetase, one of the enzymes of the urea cycle. The usual criteria for evaluation of hepatic function were normal.
D000641:Ammonia / Q000097:blood*; D000740:Anemia / Q000662:veterinary; D000818:Animals; D001119:Arginase / Q000378:metabolism; D001124:Argininosuccinate Synthase / Q000172:deficiency / Q000378:metabolism; D001798:Blood Proteins / Q000032:analysis; D004283:Dog Diseases / Q000178:diet therapy / Q000201:enzymology*; D004285:Dogs; D008099:Liver / Q000201:enzymology; D008297:Male; D009954:Ornithine Carbamoyltransferase / Q000378:metabolism; D012640:Seizures / Q000662:veterinary; D014508:Urea / Q000378:metabolism*
D001798:Blood Proteins; D000641:Ammonia; D014508:Urea; D009954:Ornithine Carbamoyltransferase; D001119:Arginase; D001124:Argininosuccinate Synthase