title: Observations on the Gy-a and Hy antigens and the antibodies that define them.
abstract: Two high frequency antigens, Hy (Holley) and Gy-a (Gregory), show an apparent association. All individuals lacking Gy-a are whites and these individuals are Hy-negative. A second group of Hy-negative individuals are blacks. All of these react weakly with anti-Gy-a. Neither Gy-a nor Hy are well developed on cord cells, although antibodies to both factors have been stimulated by pregnancy. Anti-Gy-a and anti-Hy antibodies react best in the antihuman globulin test. These antibodies have low avidity, high titers, and have been implicated as causing transfusion reactions.
mesh_terms: D000937:Antigen-Antibody Reactions; D044383:Black People; D001787:Blood Group Incompatibility; D003241:Consanguinity; D004912:Erythrocytes / Q000276:immunology*; D005260:Female; D006579:Heterozygote; D006801:Humans; D007518:Isoantibodies / Q000502:physiology*; D007519:Isoantigens; D008297:Male; D044465:White People
chemical_list: D007518:Isoantibodies; D007519:Isoantigens