[Serum lipoproteids and ketone bodies after constant infusion of sorbitol i.v. (author's transl)].
20 patients of a metabolic ward received a six-hour infusion of sorbitol at a dosis of 0.125 g/kg/h(n equal to 10) and 0.25 g/kg/h(n equal to 10) body weight. Cholesterol levels showed a significant fall in both groups (p smaller than 0.05) and triglycerides rose significantly (p smaller than 0.05). The concentrations of acetoacetate and beta-hydroxybutyrate were lowered irrespective of the dosis. The cholesterol-reducing effect can be explained by the antiketogenic action, whereas the increase in triglycerides possibly could be the result of raised alpha-glycerophosphate.
D000090:Acetoacetates / Q000097:blood; D004305:Dose-Response Relationship, Drug; D005994:Glycerophosphates; D006073:Gout / Q000097:blood / Q000378:metabolism; D006801:Humans; D006885:Hydroxybutyrates / Q000097:blood; D006949:Hyperlipidemias / Q000097:blood / Q000378:metabolism; D007263:Infusions, Parenteral; D007657:Ketone Bodies / Q000097:blood*; D008074:Lipoproteins / Q000097:blood*; D008297:Male; D009765:Obesity / Q000097:blood / Q000378:metabolism; D013012:Sorbitol / Q000008:administration & dosage* / Q000494:pharmacology; D014280:Triglycerides / Q000097:blood; D014680:Veins
D000090:Acetoacetates; D005994:Glycerophosphates; D006885:Hydroxybutyrates; D007657:Ketone Bodies; D008074:Lipoproteins; D014280:Triglycerides; D013012:Sorbitol
Serumlipoproteide und Ketonkörper nach intravenöser Dauerinfusion von Sorbit