Alterations in hepatic drug metabolism and lipid peroxidation during administration of Baygon, a pesticide.
Biochemical studies during low- and high-dose administration of Baygon (a pesticide) to young male rats were performed. It was observed that the activities of drug-metabolizing enzymes were decreased even at a low dose of Baygon and the decrease was much more significant during high-dose injections. Lipid peroxidation was increased with a low dose and the increase was much more pronounced with a high dose. Besides these changes the animals showed physical changes such as salivation, fasciculations, etc. The presence of conjugated diene absorption patterns and malonaldehyde formation indicated the in vivo lipid peroxidation dut to Baygon administration. Toxic effects leading to death were noted when the animals were injected with a high dose of the pesticide, Baygon above 25 mg/kg.
D000083:Acetanilides; D000633:Aminopyrine N-Demethylase / Q000378:metabolism*; D000818:Animals; D001835:Body Weight; D004305:Dose-Response Relationship, Drug; D050356:Lipid Metabolism; D008099:Liver / Q000033:anatomy & histology / Q000187:drug effects / Q000201:enzymology*; D008297:Male; D006899:Mixed Function Oxygenases / Q000378:metabolism*; D009929:Organ Size; D010544:Peroxidases / Q000378:metabolism*; D004364:Pharmaceutical Preparations / Q000378:metabolism*; D001074:Propoxur / Q000494:pharmacology* / Q000633:toxicity; D051381:Rats
D000083:Acetanilides; D004364:Pharmaceutical Preparations; D001074:Propoxur; D006899:Mixed Function Oxygenases; D010544:Peroxidases; D000633:Aminopyrine N-Demethylase