Actions and interactions of dipropylacetate and penicillin on evoked potentials of excised prepiriform cortex of guinea pig.
Slices from guinea pig brain containing the lateral olfactory tract (LOT) and the prepiriform cortex were studied in vitro. Field potentials, evoked by stimulation of the LOT, were recorded extracellularly. This field potential comprises a compound action potential, a surface negative wave (identified as EPSP), and superimposed positive peaks ("population spikes" or PSs) reflecting postsynaptic activity. In a previous article the penicillin-induced increase of EPSP and of both amplitude and number of PSs was described. Now we are reporting the slight depression of EPSP and PSs and the prevention of the appearance of penicillin-induced PSs by an antiepileptic drug sodium dipropylacetate (Depakine). The effect was dose-dependent. Models explaining the effects of penicillin and dipropylacetate are discussed.
D000818:Animals; D002540:Cerebral Cortex / Q000187:drug effects*; D003864:Depression, Chemical; D004305:Dose-Response Relationship, Drug; D005071:Evoked Potentials / Q000187:drug effects*; D006168:Guinea Pigs; D066298:In Vitro Techniques; D008959:Models, Neurological; D010406:Penicillins / Q000037:antagonists & inhibitors*; D014631:Valerates / Q000494:pharmacology*; D014635:Valproic Acid / Q000008:administration & dosage / Q000494:pharmacology*
D010406:Penicillins; D014631:Valerates; D014635:Valproic Acid