Dopamine-B-hydroxylase and catecholamines in an olfactory esthesioneuroma.
In a case of olfactory esthesioneuroma, of which an unfixed specimen and blood sample were available, we demonstrated immunohistochemically and biochemically the presence of dopamine-B-hydroxylase and catecholamines in low concentration. This result indicates that this nasal tumor is probably of sympathetic origin, in whole or in part, and provides a new aid in diagnosis. Furthermore, biochemical assay of dopamine, V.M.A., and H.V.A. excretion in urine could perhaps bring information of diagnostic and prognostic value before and after treatment.
D000328:Adult; D000917:Antibody Formation; D004299:Dopamine beta-Hydroxylase / Q000378:metabolism*; D004837:Epinephrine / Q000378:metabolism*; D006801:Humans; D008297:Male; D018241:Neuroectodermal Tumors, Primitive, Peripheral / Q000378:metabolism* / Q000473:pathology; D009638:Norepinephrine / Q000378:metabolism*; D009669:Nose Neoplasms / Q000201:enzymology / Q000378:metabolism* / Q000473:pathology
D004299:Dopamine beta-Hydroxylase; D009638:Norepinephrine; D004837:Epinephrine