title: Half chromatid mutations: transmission in humans?
abstract: Attention is drawn to the possibility of half chromatid and early somatic mutations and to several implications of these mosaic-yielding events. There is suggestive evidence that spontaneous mutations can result in mosaics. A world-wide cooperative study of Lesch-Nyhan families could determine the extent of half chromatid mutation transmission and early somatic mutation in humans.
mesh_terms: D001483:Base Sequence; D002842:Chromatids; D004261:DNA Replication; D004277:DNA, Single-Stranded; D005260:Female; D005808:Genes, Recessive; D014644:Genetic Variation; D005838:Genotype; D006801:Humans; D007926:Lesch-Nyhan Syndrome / Q000235:genetics*; D008297:Male; D009030:Mosaicism; D009154:Mutation; D010375:Pedigree; D011336:Probability; D012641:Selection, Genetic; D012730:Sex Chromosomes
chemical_list: D004277:DNA, Single-Stranded