Effect of a potent interferon inducer on acute and chronic lactic dehydrogenase virus viremia.
The effect of a single and multiple doses of polyinosinic-polycytidylic acid (poly (I). poly(C) on lactic dehydrogenase virus viremia has been studied. A single injection of 200 mug of poly (I)-poly(C) given 6 h before infection with lactic dehydrogenase virus caused a temporary decrease in viremia of about 2.5 log10. Repeated injections of 100 mug of poly(I)-poly(C) every 24 h beginning at -24 h caused a temporary decrease in viremia of about 4.0 log 10. Therapeutic treatment with optimal dosage schedules (100 mug every 24 h) caused a reduction in viremia of 1.0 to 2.0 log10. This decrease lasted for at least 24 h after the treatment was stopped. Some possible reasons for the limited effectiveness of poly (I)-poly(C) in this system are discussed.
D000818:Animals; D001769:Blood / Q000382:microbiology; D007275:Injections, Intravenous; D007369:Interferon Inducers; D007772:Lactate dehydrogenase-elevating virus / Q000187:drug effects*; D051379:Mice; D011070:Poly I-C / Q000008:administration & dosage / Q000627:therapeutic use*; D012328:RNA Viruses / Q000187:drug effects*; D014777:Virus Diseases / Q000188:drug therapy* / Q000517:prevention & control
D007369:Interferon Inducers; D011070:Poly I-C