[The effect of salicylic acid on epidermal cell proliferation kinetics in psoriasis. Autoradiographic in vitro-investigations(author's transl)].
Salicylic acid in the therapeutic concentrations from 0.5 to 10% does not affect the rate of proliferation of psoriatic epidermal cells. In 18 patients suffering from psoriasis the H3-I (H3-thymidine labelling index) was determined using autoradiographic in vitro labelling techniques. In 12 of these patients double-labelling with C14-and H3-thymidine was used to determine the H3-I, the DNA-synthesis time (ts) and the duration of the cell-cycle (tc). No significant changes were observed following external application of salicyclic acid in white Vaseline in concentrations of 0.5, 2 and 10% for one week.
D001345:Autoradiography; D002250:Carbon Radioisotopes; D002455:Cell Division / Q000187:drug effects*; D002465:Cell Movement / Q000187:drug effects; D004247:DNA / Q000096:biosynthesis; D004338:Drug Combinations; D004347:Drug Interactions; D005260:Female; D006801:Humans; D066298:In Vitro Techniques; D008297:Male; D009824:Ointments; D010087:Oxides / Q000627:therapeutic use; D011565:Psoriasis / Q000188:drug therapy*; D012459:Salicylates / Q000494:pharmacology* / Q000627:therapeutic use; D012867:Skin / Q000473:pathology*; D013936:Thymidine / Q000378:metabolism; D013997:Time Factors; D014316:Tritium; D015032:Zinc / Q000627:therapeutic use
D002250:Carbon Radioisotopes; D004338:Drug Combinations; D009824:Ointments; D010087:Oxides; D012459:Salicylates; D014316:Tritium; D004247:DNA; D015032:Zinc; D013936:Thymidine
Die Wirkung der Salicylsüre auf die Proliferationskinetik psoriatischer Epidermiszellen. Autoradiographische in vitro-Untersuchungen