Penetration of fluorometholone into the cornea and aqueous humor.
In each of the experimental conditions studied, fluorometholone penetrated into the cornea and aqueous humor following topical administration of a standard drop. The amount of drug measured in each location was less than that previously documented for dexamethasone and prednisolone preparations. In contrast to these more conventional steroids, the ocular penetration of fluorometholone appeared to be unaffected by the presence or absence of the corneal epithelium or of intraocular inflammation.
D000287:Administration, Topical; D000818:Animals; D001082:Aqueous Humor / Q000032:analysis; D002855:Chromatography, Thin Layer; D003315:Cornea / Q000378:metabolism* / Q000601:surgery; D003907:Dexamethasone / Q000378:metabolism; D004848:Epithelium / Q000601:surgery; D005128:Eye Diseases / Q000378:metabolism; D005469:Fluorometholone / Q000008:administration & dosage / Q000378:metabolism*; D006207:Half-Life; D007249:Inflammation; D011239:Prednisolone / Q000378:metabolism; D011817:Rabbits; D013997:Time Factors; D014316:Tritium
D014316:Tritium; D003907:Dexamethasone; D011239:Prednisolone; D005469:Fluorometholone