title: The spleen as a hematological organ.
abstract: The spleen has multiple roles in human physiology. Eitht major functions are discussed in this review (hematopoiesis, erythrocyte destruction, hormonal function in hematopoiesis, culling and pitting, platelet and leukocyte destruction, particulate removal, reservoir function, and immunologic function). Splenic trapping of red cells, and the concepts of hypersplenism, are major responsibilities of this organ. These aspects are placed in perspective for the reader.
mesh_terms: D000743:Anemia, Hemolytic / Q000503:physiopathology; D000747:Anemia, Hypochromic / Q000503:physiopathology; D001792:Blood Platelets; D002467:Cell Nucleus; D002470:Cell Survival; D002860:Chromium Radioisotopes; D003102:Colloids; D004912:Erythrocytes; D004913:Erythrocytes, Abnormal; D006410:Hematopoiesis; D006457:Hemoglobinuria, Paroxysmal / Q000503:physiopathology; D006801:Humans; D006971:Hypersplenism / Q000175:diagnosis; D007504:Iron Radioisotopes; D007962:Leukocytes; D055728:Primary Myelofibrosis / Q000503:physiopathology; D013103:Spherocytosis, Hereditary / Q000503:physiopathology; D013154:Spleen / Q000002:abnormalities / Q000098:blood supply / Q000276:immunology / Q000502:physiology* / Q000503:physiopathology; D013156:Splenectomy / Q000009:adverse effects; D013789:Thalassemia / Q000503:physiopathology; D014923:Wiskott-Aldrich Syndrome / Q000503:physiopathology
chemical_list: D002860:Chromium Radioisotopes; D003102:Colloids; D007504:Iron Radioisotopes