Decontamination procedures for skin exposed to phenolic substances.
Spraying or swabbing with a mixture of polyethylene glycol 300/industrial methylated spirits (PEG-300/IMS) (2:1 by volume) has been shown to substantially reduce mortality, systemic effects, and skin burns resulting from skin contamination by phenol, cumene hydroperoxide, or phenol/acetone cleavage product. The skin-damaging potentials of sodium hydroxide and sulfuric acid have also been investigated. PEG-300/IMS(2:1 by volume) mixture was found, in rats, to be slightly less effective than water as means of decontamination. The PEG-300/IMS mixture has been shown not to cause eye irritation, and so should not present a hazard where this mixture is used as a decontaminant spray.
D000096:Acetone / Q000633:toxicity; D000473:Alkanes / Q000627:therapeutic use; D000818:Animals; D001593:Benzyl Compounds / Q000633:toxicity; D002057:Burns, Chemical / Q000150:complications / Q000209:etiology / Q000628:therapy*; D003666:Decontamination / Q000379:methods*; D003902:Detergents / Q000008:administration & dosage / Q000627:therapeutic use; D005123:Eye / Q000187:drug effects; D005990:Glycerol / Q000627:therapeutic use; D007928:Lethal Dose 50; D000432:Methanol / Q000008:administration & dosage / Q000627:therapeutic use; D009787:Occupational Medicine; D010545:Peroxides / Q000633:toxicity*; D010636:Phenols / Q000633:toxicity*; D011092:Polyethylene Glycols / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*; D000644:Quaternary Ammonium Compounds / Q000008:administration & dosage / Q000627:therapeutic use; D011817:Rabbits; D051381:Rats; D012869:Skin Absorption / Q000187:drug effects; D012972:Sodium Hydroxide / Q000633:toxicity; D013464:Sulfuric Acids / Q000633:toxicity; D014867:Water
D000473:Alkanes; D001593:Benzyl Compounds; D003902:Detergents; D010545:Peroxides; D010636:Phenols; D000644:Quaternary Ammonium Compounds; D013464:Sulfuric Acids; D014867:Water; D000096:Acetone; D011092:Polyethylene Glycols; D012972:Sodium Hydroxide; D005990:Glycerol; D000432:Methanol