title: Response of homozygous and heterozygous xeroderma pigmentosum cells to several chemical and viral carcinogens.
abstract: The topics discussed include the relationship between the carcinogenic property of various compounds and their capacity to elicit DNA damage that results in a DNA repair synthesis; the metabolic activation of precarcinogens; the in vivo use of DNA repair synthesis in the identification of tissues that will give rise to neoplasms; the possible involvement of DNA repair in the sensitivity of human cells to the chromosome-damaging and lethal effect of chemical carcinogens; the different responses of homozygous xeroderma pigmentosum (XP) cells, heterozygous XP cells, and controls to some but not all chemical carcinogens and oncogenic viruses; and the possible link between DNA damage, its repair, and viral-induced neoplastic transformation.
mesh_terms: D002273:Carcinogens / Q000494:pharmacology*; D002875:Chromosomes / Q000378:metabolism / Q000528:radiation effects; D004260:DNA Repair / Q000187:drug effects*; D004273:DNA, Neoplasm / Q000096:biosynthesis; D005347:Fibroblasts / Q000187:drug effects / Q000378:metabolism; D006579:Heterozygote; D006720:Homozygote; D006801:Humans; D009154:Mutation; D011830:Radiation Effects; D014466:Ultraviolet Rays; D014983:Xeroderma Pigmentosum / Q000235:genetics / Q000378:metabolism*
chemical_list: D002273:Carcinogens; D004273:DNA, Neoplasm