[Increasing the non-specific resistance of animals to staphylococcus with official RNA preparations].
A single or double parenteral injection to mice of sodium nucleinate considerably elevated their nonspecific resistance to the virulent staphylococcus as soon as in four hours; the resistance remained marked for four days. Daily prolonged injection of the stimulant also proved to be very effective. In the simulated organism there occurred a significant depression of reproduction of the virulent staphylococci and an increase in the amount of phagocytic cells and their digestive activity. The latter served as a material basis for induced nonspecific resistance. The data obtained substantiated a possibility of using sodium nucleinate as an antibacterial nonspecific stimulant under clinical conditions.
D000818:Animals; D008264:Macrophages / Q000276:immunology; D051379:Mice; D009504:Neutrophils / Q000276:immunology; D010587:Phagocytosis; D012313:RNA / Q000008:administration & dosage / Q000302:isolation & purification / Q000627:therapeutic use*; D012480:Salmonella Infections / Q000517:prevention & control; D013154:Spleen / Q000382:microbiology; D013203:Staphylococcal Infections / Q000276:immunology / Q000382:microbiology / Q000517:prevention & control*; D015003:Yeasts / Q000032:analysis
D012313:RNA
Povyshenie nespetsificheskoĭ ustoĭchivosti zhivotnykh k stafilokokku ofitsinal'nymi preparatami RNK