[The influence of inhalation anaesthetics on catecholamine secretion from the adrenal medulla in vivo].
The influence of chloroform and ether on the catecholamine (CA) secretion from the adrenal medulla was investigated in cats in order to compare these effects to those of halothane and methoxyflurane studied previously. The CA concentrations in the blood of the adrenolumbar vein were measured spectrofluorometrically. During inhalation of chloroform (1.0-1.5%) no significant changes of spontaneous CA secretion were observed; contrary to that, the secretion evoked by splanchnic nerve stimulation was decreased. During inhalation of ether (4.0-6.0%) spontaneous CA output was increased and the CA release evoked by splanchnic nerve stimulation was inhibited. The results differ qualitatively from those obtained with methoxyflurane and halothane; these anesthetics caused a pronounced inhibition of spontaneous CA output. The inhibition by ether of CA secretion evoked by splanchnic nerve stimulation was less pronounced than that caused by the other anaesthetics. By comparison of the effects of four inhalation anaesthetics we evaluated, which circulatory side effects depend on changes of CA output.
D000313:Adrenal Medulla / Q000187:drug effects* / Q000378:metabolism; D000769:Anesthesia, Inhalation; D000818:Animals; D002395:Catecholamines / Q000097:blood / Q000378:metabolism*; D002415:Cats; D002725:Chloroform / Q000494:pharmacology*; D004837:Epinephrine / Q000378:metabolism; D005019:Ethyl Ethers / Q000494:pharmacology*; D005260:Female; D006221:Halothane / Q000494:pharmacology; D008297:Male; D008733:Methoxyflurane / Q000494:pharmacology; D009638:Norepinephrine / Q000378:metabolism; D013050:Spectrometry, Fluorescence; D013153:Splanchnic Nerves
D002395:Catecholamines; D005019:Ethyl Ethers; D008733:Methoxyflurane; D002725:Chloroform; D006221:Halothane; D009638:Norepinephrine; D004837:Epinephrine
Einfluss von Inhalationsnarkotica auf die Katecholaminsekretion aus dem Nebennierenmark in vivo