title: [The cardiovascular manifestations of Paget's disease].
abstract: After reviewing the old ideas (peripheral syndrome and cardiac insufficiency at high outputs) and more recent ideas (arterial and intracardiac vascular calcification), the authors report their experiences based on the study of the histories of 150 patients suffering from Paget's disease followed for several years. First they emphasize the frequent latency of cardiac manifestations looked for systematically by means of the electrocardiogram particularly during evolutive stages of the disease. Electrocardiographic disturbances were observed 91 times and included 43 cases of conduction disorders and 48 of repolarization disorders; their distribution was studied as a function of various inherent parameters, of the patient (age and sex) and of the disease (its evolutive character and its degree of diffusion). On the basis of the anti-arythmic power of calcitonin found during experiments and obtained excellent results three times. Finally the place of cardiovascular manifestations in the pathogenic hypotheses and nosology of Paget's disease is discussed.
mesh_terms: D000328:Adult; D000367:Age Factors; D000368:Aged; D001145:Arrhythmias, Cardiac / Q000209:etiology; D002114:Calcinosis / Q000209:etiology; D002116:Calcitonin / Q000494:pharmacology / Q000627:therapeutic use; D002986:Clinical Trials as Topic; D003327:Coronary Disease / Q000209:etiology; D004562:Electrocardiography; D005260:Female; D006321:Heart / Q000187:drug effects; D006327:Heart Block / Q000209:etiology; D006331:Heart Diseases / Q000188:drug therapy / Q000209:etiology*; D006337:Heart Murmurs; D006349:Heart Valve Diseases / Q000209:etiology; D006801:Humans; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000209:etiology; D010001:Osteitis Deformans / Q000150:complications*; D012737:Sex Factors; D014652:Vascular Diseases / Q000209:etiology
chemical_list: D002116:Calcitonin
vernacular_title: Les manifestations cardio-vasculaires de la maladie de Paget