Induction of carcinoma of the large intestine in guinea pigs by intratectal instillation of N-methyl-N-nitrosourea.
Intrarectal administration of 0.5 ml of a 0.25 percent solution of N-methyl-N-nitrosourea twice seekly for 42 weeks to female inbred strain-2 guinea pigs induced large-bowel adenocarcinomas in 9 of 10 animals in 38-56 weeks. Controls did not show cancer. The lesions were infiltrative or constrictive, which distinguished them from chemically induced large-bowel cancers of rats and mice.
D000230:Adenocarcinoma / Q000139:chemically induced / Q000473:pathology; D000818:Animals; D002273:Carcinogens / Q000008:administration & dosage; D006168:Guinea Pigs; D007414:Intestinal Neoplasms / Q000139:chemically induced* / Q000473:pathology; D007420:Intestine, Large; D009374:Neoplasms, Experimental / Q000139:chemically induced / Q000473:pathology; D009607:Nitrosourea Compounds / Q000008:administration & dosage; D012007:Rectum
D002273:Carcinogens; D009607:Nitrosourea Compounds