[Sensitivity of certain strains of pathogenic Leptospira to streptomycin, the nature of resistant variants and the frequency of their occurrence].
Streptomycin sensitivity of 112 Leptospira strains isolated from domestic and wild animals was studied. Independent of the isolation period and nature the strains proved to be highly sensitive to the antiobiotic (MIC 0.1 to 0.5 gamma/ml). On the example of a clone strain of Leptospira it was shown with a fluctuation test that streptomycin resistance occurred spontaneously. Frequency of the streptomycin resistant mutations was determined for 5 clone strains of L. interrogans. It was 10-9 to 10-7 per a Leptospira.
D000818:Animals; D002417:Cattle; D002999:Clone Cells / Q000382:microbiology; D003470:Culture Media; D004305:Dose-Response Relationship, Drug; D004352:Drug Resistance, Microbial; D005787:Gene Frequency / Q000187:drug effects*; D014644:Genetic Variation / Q000187:drug effects*; D006801:Humans; D007919:Leptospira / Q000187:drug effects*; D008826:Microbial Sensitivity Tests; D009154:Mutation / Q000187:drug effects; D012377:Rodentia / Q000382:microbiology; D012703:Serotyping; D013307:Streptomycin / Q000494:pharmacology*; D013552:Swine / Q000382:microbiology; D013997:Time Factors
D003470:Culture Media; D013307:Streptomycin
Chuvstvitel'nost' nekotorykh shtammov patogennykh leptospir k streptomitsinu, priroda ustoĭchivykh k nemu variantov i chastota ikh vozniknoveniia