title: Comparison of secretin and vasoactive intestinal peptide on pancreatic secretion in dogs.
abstract: Vasoactive inhibitory peptide (VIP) and secretin were compared in regard to the stimulation of pancreatic bicarbonate secretion and the augmentation of pancreatic response to caerulein or a peptone meal in chronic gastric and pancreatic fistula dogs. Dose-response analysis showed that maximal bicarbonate response to VIP was about 17% of that to secretin. Both caerulein and endogenous cholecystokinin, released by a peptone meal, clearly potentiated pancreatic bicarbonate response to VIP in a manner similar to secretin. The interactions of these two peptides showed that VIP is a potent inhibitor of secretin-induced pancreatic secretion. From the dose-response curves to secretin alone and secretin plus VIP, Michaelis-Menten analysis showed typical competitive inhibition, which indicates that VIP and secretin share a common receptor site.
mesh_terms: D000681:Amylases / Q000378:metabolism; D000818:Animals; D001639:Bicarbonates / Q000378:metabolism; D002108:Ceruletide / Q000494:pharmacology; D002766:Cholecystokinin / Q000494:pharmacology; D003864:Depression, Chemical; D004285:Dogs; D004305:Dose-Response Relationship, Drug; D004338:Drug Combinations; D004357:Drug Synergism; D005747:Gastric Fistula; D005768:Gastrointestinal Hormones / Q000008:administration & dosage / Q000494:pharmacology*; D007263:Infusions, Parenteral; D007700:Kinetics; D010179:Pancreas / Q000187:drug effects* / Q000378:metabolism; D010185:Pancreatic Fistula; D010189:Pancreatic Juice / Q000378:metabolism; D010455:Peptides / Q000008:administration & dosage / Q000494:pharmacology*; D010461:Peptones / Q000494:pharmacology; D011506:Proteins / Q000378:metabolism; D012633:Secretin / Q000008:administration & dosage / Q000494:pharmacology*
chemical_list: D001639:Bicarbonates; D004338:Drug Combinations; D005768:Gastrointestinal Hormones; D010455:Peptides; D010461:Peptones; D011506:Proteins; D012633:Secretin; D002108:Ceruletide; D002766:Cholecystokinin; D000681:Amylases