title: Pharmacokinetics of ticarcillin in patients with abnormal renal function.
abstract: The pharmacokinetics of ticarcillin were determined in patients with abnormal renal function. In individuals with rates of creatinine clearance of greater than 60 ml per min, the half-life (+/- standard deviation) of ticarcillin was 71 +/- 6 min after intravenous administration. In patients with rates of creatinine clearance of 30-60 ml per min, 10-30 ml per min, and less than 10 ml per min, ticarcillin had a half-life of 3.0 +/- 0.6 hr, 8.5 +/- 2.1 hr, and 14.8 +/- 3.7 hr, respectively. Urinary concentrations of ticarcillin after intravenous administration were adequate at all levels of renal function. Ticarcillin was removed by hemodialysis with a reduction in half-life to 3.4 +/- 0.8 hr, but peritoneal dialysis was minimally effective in removing the drug. A program for the use of ticarcillin patients with renal insufficiency was outlined.
mesh_terms: D002986:Clinical Trials as Topic; D004305:Dose-Response Relationship, Drug; D006207:Half-Life; D006801:Humans; D007668:Kidney / Q000187:drug effects* / Q000503:physiopathology; D007674:Kidney Diseases / Q000188:drug therapy; D008657:Metabolic Clearance Rate; D010406:Penicillins / Q000494:pharmacology*; D006435:Renal Dialysis; D013982:Ticarcillin / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use / Q000652:urine
chemical_list: D010406:Penicillins; D013982:Ticarcillin