Fanconi's anemia. II. Are multiple endocrine insufficiencies a substantial part of the disease?
Three children with Fanconi's anemia belonging to a family where 6 children had the disease were investigated. One child had growth hormone deficiency, a second child showed subnormal response of testosterone to gonadotropin stimulation and the third child had a missing insulin release following arginine. This report shows that growth hormone deficiency is not necessarily liniked with Fanconi's anemia when it occurs in a family. Multiple endocrine insufficiencies do no appear to be part of the disease.
D015065:17-Hydroxycorticosteroids / Q000097:blood; D015068:17-Ketosteroids / Q000652:urine; D000741:Anemia, Aplastic / Q000503:physiopathology*; D001120:Arginine; D001786:Blood Glucose / Q000032:analysis; D001827:Body Height; D001835:Body Weight; D002648:Child; D002675:Child, Preschool; D004702:Endocrine Glands / Q000503:physiopathology*; D005199:Fanconi Anemia / Q000503:physiopathology*; D013006:Growth Hormone / Q000097:blood / Q000378:metabolism*; D006801:Humans; D006854:Hydrocortisone / Q000097:blood; D007328:Insulin / Q000097:blood / Q000378:metabolism*; D000078790:Insulin Secretion; D007515:Islets of Langerhans / Q000503:physiopathology; D007986:Luteinizing Hormone / Q000097:blood; D008297:Male; D008797:Metyrapone; D010903:Pituitary Gland, Anterior / Q000503:physiopathology; D013737:Testis / Q000503:physiopathology; D013739:Testosterone / Q000097:blood / Q000378:metabolism*; D013974:Thyroxine / Q000097:blood; D014508:Urea / Q000097:blood
D015065:17-Hydroxycorticosteroids; D015068:17-Ketosteroids; D001786:Blood Glucose; D007328:Insulin; D013739:Testosterone; D014508:Urea; D007986:Luteinizing Hormone; D013006:Growth Hormone; D001120:Arginine; D013974:Thyroxine; D006854:Hydrocortisone; D008797:Metyrapone