title: The effect of oxytocin on blood vessels of cremaster muscle of the rat.
abstract: Oxytocin administered intravenously to the anaesthetized rat produced dilatation of the blood vessels of the cremaster muscle at concentrations ranging from 2.5 times 10-minus 11 to 2.5 times 10-minus 9 M. When applied topically to the exposed vessels it produced constriction at concentrations ranging from 2.5 times 10-minus 12 to 5.0 times 10-minus 8 M. Oxytocin was thus similar to adrenaline in eliciting opposite effects when applied to the serosa or to the intima of skeletal muscle blood vessels.
mesh_terms: D000287:Administration, Topical; D000818:Animals; D001808:Blood Vessels / Q000187:drug effects*; D066298:In Vitro Techniques; D007275:Injections, Intravenous; D008297:Male; D009132:Muscles / Q000098:blood supply*; D010121:Oxytocin / Q000008:administration & dosage / Q000494:pharmacology*; D051381:Rats; D012039:Regional Blood Flow / Q000187:drug effects; D014662:Vasoconstrictor Agents / Q000494:pharmacology; D014665:Vasodilator Agents / Q000494:pharmacology
chemical_list: D014662:Vasoconstrictor Agents; D014665:Vasodilator Agents; D010121:Oxytocin