title: Initial chemotherapeutic trials in patients with inoperable or recurrent cancer of the prostate.
abstract: This paper describes a random study being conducted to compare the value of 5-fluorouracil plus diethylstilbestrol vs diethylstilbestrol alone and the value of 5-fluorouracil vs CCNU in the treatment of stage D adenocarcinoma of the prostate. We have established that similar normal values of acid phosphatase are encountered in serum and bone marrow of patients with nonmalignant and malignant diseases without osseous metastasis.
mesh_terms: D000135:Acid Phosphatase / Q000097:blood; D000230:Adenocarcinoma / Q000188:drug therapy* / Q000201:enzymology; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D004054:Diethylstilbestrol / Q000627:therapeutic use; D005472:Fluorouracil / Q000627:therapeutic use; D006801:Humans; D008297:Male; D009362:Neoplasm Metastasis; D009607:Nitrosourea Compounds / Q000627:therapeutic use; D011471:Prostatic Neoplasms / Q000188:drug therapy* / Q000201:enzymology; D012008:Recurrence
chemical_list: D000970:Antineoplastic Agents; D009607:Nitrosourea Compounds; D004054:Diethylstilbestrol; D000135:Acid Phosphatase; D005472:Fluorouracil