The relative safety of polymethylmethacrylate. A controlled clinical study of randomly selected patients treated with Charnley and ring total hip replacements.
Forty patients from a group of seventy elected to participate in a prospective randomized clinical study designed to evaluate the systemic effects of polymethylmethacrylate implanted with a Charnley total hip replacement, utilizing patients treated with a Ring total hip prosthesis ad controls. Intraoperative alterations in cardiovascular function were related to use of methylmethacrylate, but postoperative changes in pulmonary function, erythrocyte sedimentation rate, serum lactic acid dehydrogenase, serum glutamicoxalacetic transaminase, and alkaline phosphatase were not. Charnley total hip replacements were associated with more ectopic-bone formation twelve months postoperatively. The two "latent" infections recognized during the thirty-four months of the study were in hips without acrylic fixation.
D000469:Alkaline Phosphatase / Q000097:blood; D001172:Arthritis, Rheumatoid / Q000601:surgery; D001178:Arthroplasty; D001219:Aspartate Aminotransferases / Q000097:blood; D001794:Blood Pressure / Q000187:drug effects; D002302:Cardiac Output / Q000187:drug effects; D002318:Cardiovascular Diseases / Q000139:chemically induced; D056486:Chemical and Drug Induced Liver Injury / Q000201:enzymology / Q000209:etiology; D004341:Drug Evaluation; D005260:Female; D006339:Heart Rate / Q000187:drug effects; D006621:Hip Joint / Q000601:surgery*; D006801:Humans; D007249:Inflammation / Q000139:chemically induced; D007595:Joint Prosthesis; D007770:L-Lactate Dehydrogenase / Q000097:blood; D008171:Lung Diseases / Q000139:chemically induced; D008297:Male; D008768:Methylmethacrylates / Q000009:adverse effects*; D008875:Middle Aged; D010100:Oxygen / Q000097:blood; D010313:Partial Pressure; D011183:Postoperative Complications / Q000139:chemically induced* / Q000201:enzymology; D014655:Vascular Resistance / Q000187:drug effects; D014945:Wound Healing
D008768:Methylmethacrylates; D007770:L-Lactate Dehydrogenase; D001219:Aspartate Aminotransferases; D000469:Alkaline Phosphatase; D010100:Oxygen