title: Major factors in the development of diabetes mellitus in 10,000 men.
abstract: The average annual incidence of diabetes among 8,688 adult men followed up for five years was 8.0/1,000 with Asian, African and Israeli-born having higher rates than European-born. Multivariate analysis of the findings suggested the following: the most significant variables associated with the development of diabetes are overweight and peripheral vascular disease; the high incidence of diabetes in immigrants from Asia and Africa might be an example of Neel's "thrifty genotype" or failure of adaptation to relatively rapid environmental changes; serum cholesterol level, blood pressure, uric acid level, and education were important also; and the probability of developing diabetes within five years rises from 17/1,000 (when the major variables are low or absent) to 450/1,000 (when they are high and present). This has important clinical implications.
mesh_terms: D000222:Adaptation, Physiological; D000328:Adult; D000352:Africa, Northern / Q000208:ethnology; D000367:Age Factors; D001208:Asia / Q000208:ethnology; D001786:Blood Glucose / Q000032:analysis; D001794:Blood Pressure; D001827:Body Height; D001835:Body Weight; D002784:Cholesterol / Q000097:blood; D003920:Diabetes Mellitus / Q000453:epidemiology* / Q000235:genetics; D004522:Educational Status; D005006:Ethnicity; D005060:Europe / Q000208:ethnology; D005838:Genotype; D005951:Glucose Tolerance Test; D006801:Humans; D007383:Intermittent Claudication / Q000453:epidemiology; D007557:Israel; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D012306:Risk; D014527:Uric Acid / Q000097:blood; D014652:Vascular Diseases / Q000453:epidemiology
chemical_list: D001786:Blood Glucose; D014527:Uric Acid; D002784:Cholesterol