Similarity of acetaldehyde and sulfhydryl reagent actions on the perfused guinea pig heart.
The effects of acetaldehyde (1 mM) and two known sulfhydryl reagents, diamide (0.25 mM) and cystamine (0.5 mM), on the perfused guinea pig heart were compared and were found to be markedly similar. All compounds increased heart rate and coronary flow. Dichloroisoproterenol blocked the increase in heart rate but not the increase in coronary flow. It is concluded that acetaldehyde may produce its effects by reaction with cellular thiols.
D000079:Acetaldehyde / Q000494:pharmacology*; D000818:Animals; D001391:Azo Compounds / Q000494:pharmacology; D003326:Coronary Circulation / Q000187:drug effects; D003538:Cystamine / Q000494:pharmacology; D005559:Formamides / Q000494:pharmacology; D006168:Guinea Pigs; D006321:Heart / Q000187:drug effects*; D006339:Heart Rate / Q000187:drug effects; D008297:Male; D010477:Perfusion; D013439:Sulfhydryl Reagents / Q000494:pharmacology*
D001391:Azo Compounds; D005559:Formamides; D013439:Sulfhydryl Reagents; D000079:Acetaldehyde; D003538:Cystamine