title: Intrinsic asthma associated with diabetes mellitus; abnormal vascular response and glucose tolerance tests.
abstract: Patients manifesting intrinsic idiopathic rhinitis and/or asthma in association with diabetes or aspirin intolerance were studied. Various metabolites (sugars and L-histidine) and chemical (aspirin, insulin and glucagon) challenges were studied using the parameter of the induced sequential vascular response. A standard oral glucose tolerance test was also correlated. The results indicated similar as well as divergent ab- nc. nalities of responses to the various carbohydrates, insulin, glucagon, L-histidine and aspirin challenges. This permitted a separation of some patients with idiopathic rhinitis and/or asthma into those associated with diabetes and those with tolerance to aspirin.
mesh_terms: D001241:Aspirin / Q000009:adverse effects / Q000494:pharmacology; D001249:Asthma / Q000150:complications*; D001780:Blood Coagulation Tests; D002083:Butylated Hydroxyanisole / Q000009:adverse effects; D002084:Butylated Hydroxytoluene / Q000009:adverse effects; D048909:Diabetes Complications; D004342:Drug Hypersensitivity / Q000150:complications; D005632:Fructose / Q000494:pharmacology; D005690:Galactose / Q000494:pharmacology; D005934:Glucagon / Q000494:pharmacology; D005947:Glucose / Q000494:pharmacology; D005951:Glucose Tolerance Test; D006639:Histidine / Q000494:pharmacology; D006801:Humans; D007328:Insulin / Q000494:pharmacology; D007454:Iodides / Q000009:adverse effects; D011136:Polysorbates / Q000009:adverse effects; D006255:Rhinitis, Allergic, Seasonal / Q000150:complications; D012882:Skin Tests
chemical_list: D007328:Insulin; D007454:Iodides; D011136:Polysorbates; D002084:Butylated Hydroxytoluene; D002083:Butylated Hydroxyanisole; D005632:Fructose; D006639:Histidine; D005934:Glucagon; D005947:Glucose; D001241:Aspirin; D005690:Galactose