The influence of carbenoxolone on steroid-induced ulcer and mucus secretion in the rat.
In rats, gastric mucus was decreased by starvation. The administration of carbenoxolone sodium, prednisolone, or their combination to starved rats brought the level of gastric mucus to that of nonstarved controls. Concomitant treatment with carbenoxolone sodium did not prevent prednisolone-induced ulceration of the glandular stomach in starved rats. The ulcerations of the prostomach (squamous spithelium)induced by starvation were prevented by carbenoxolone sodium, prednisolone, or the combination of the two.
D000818:Animals; D001835:Body Weight; D005260:Female; D005753:Gastric Mucosa / Q000378:metabolism; D009093:Mucus / Q000378:metabolism*; D011239:Prednisolone; D051381:Rats; D013217:Starvation; D013270:Stomach / Q000187:drug effects / Q000473:pathology; D013276:Stomach Ulcer / Q000139:chemically induced* / Q000473:pathology / Q000517:prevention & control; D014315:Triterpenes / Q000494:pharmacology* / Q000627:therapeutic use
D014315:Triterpenes; D011239:Prednisolone