title: Experimental amyloidosis: the inducer is a polyclonal B-cell activator to which susceptibility is under genetic control.
abstract: Experimental amyloidosis in mice can be induced by repeated injections of casein. It has now been demonstrated that casein induces strong polyclonal antibody synthesis in mouse B spleen lymphocytes. This effect is much more pronounced in spleen cells from anyloid-susceptible mice (CBA/J) than amyloid-resistant mice (A/J). It is suggested that amyloidosis can be due in some instances to a constant exposure for molecules which induce polyclonal B-cell activation.
mesh_terms: D000686:Amyloidosis / Q000139:chemically induced* / Q000235:genetics / Q000276:immunology; D000818:Animals; D000917:Antibody Formation; D001402:B-Lymphocytes / Q000276:immunology*; D002364:Caseins; D004247:DNA / Q000096:biosynthesis; D004926:Escherichia coli; D037102:Lectins; D008070:Lipopolysaccharides; D051379:Mice; D008815:Mice, Inbred Strains; D008934:Mitogens; D011135:Polysaccharides, Bacterial; D013154:Spleen / Q000276:immunology*; D013601:T-Lymphocytes / Q000276:immunology
chemical_list: D002364:Caseins; D037102:Lectins; D008070:Lipopolysaccharides; D008934:Mitogens; D011135:Polysaccharides, Bacterial; D004247:DNA