Clearance of cryoprecipitated factor VIII in canine hemophilia A.
Canine factor VIII was isolated by a cryoprecipitation method and injected into dogs with hemophilia A. Assays of factor VIII in the cryoprecipitate resulted in a range of 92 to 660% of the factor VIII level of normal dog plasma, with a mean of 266%. Half times of the cryoprecipitate in the hemophiliac dogs, as measured by the partial thromboplastin time (PTT) test, ranged from 7.7 to 32.3 hours, with a mean of 13.2 hours.
D000818:Animals; D001772:Blood Cell Count; D001780:Blood Coagulation Tests; D001792:Blood Platelets; D011232:Chemical Precipitation; D003080:Cold Temperature; D004283:Dog Diseases / Q000097:blood* / Q000188:drug therapy; D004285:Dogs; D005169:Factor VIII / Q000032:analysis* / Q000302:isolation & purification / Q000627:therapeutic use; D005340:Fibrinogen / Q000032:analysis; D006467:Hemophilia A / Q000097:blood / Q000188:drug therapy / Q000662:veterinary*; D008297:Male; D011517:Prothrombin Time; D013997:Time Factors
D005169:Factor VIII; D005340:Fibrinogen