title: Platelet reactivity ex vivo and in vivo after acute and chronic treatment with sodium caprylate.
abstract: The effect of sodium caprylate on platelet function and other hematological parameters was studied, using rabbits as experimental animals. Intravenous administration of caprylate resulted in a pronounced, although transient, inhibition of platelet reactivity as measured by the laser technique. A single oral dose of caprylate had no effect on platelet adhesiveness. Long-term oral administration of caprylate (2 and 3 weeks) to rabbits resulted in a progressive and significant decrease in platelet adhesiveness in these animals compared to that in a control group receiving saline. However, the platelet reactivity to laser damage was not changed after administration of caprylate for 3 weeks. Other hematological parameters such as hematocrit, plasma cholesterol, triglycerides, and ketone body concentrations were not altered by the treatment.
mesh_terms: D000090:Acetoacetates / Q000097:blood; D000284:Administration, Oral; D000818:Animals; D001792:Blood Platelets / Q000187:drug effects*; D001835:Body Weight; D002087:Butyrates / Q000097:blood; D002210:Caprylates / Q000008:administration & dosage / Q000494:pharmacology*; D002784:Cholesterol / Q000097:blood; D005260:Female; D006400:Hematocrit; D007275:Injections, Intravenous; D007657:Ketone Bodies / Q000097:blood; D007834:Lasers; D008297:Male; D010973:Platelet Adhesiveness / Q000187:drug effects; D010974:Platelet Aggregation / Q000187:drug effects; D011817:Rabbits; D013997:Time Factors; D014280:Triglycerides / Q000097:blood
chemical_list: D000090:Acetoacetates; D002087:Butyrates; D002210:Caprylates; D007657:Ketone Bodies; D014280:Triglycerides; D002784:Cholesterol