title: Porphyria in relation to surgery and anaesthesia.
abstract: A review is presented of the more recent biochemical findings in the hepatic porphyrias. The clinical aspects of acute porphyria are re-emphasized and illustrated with a case history. In particular the differentiation between porphyria and surgical causes of abdominal pain is stressed. The anaesthetic management is discussed and details of diagnostic and screening tests are given.
mesh_terms: D000624:5-Aminolevulinate Synthetase / Q000378:metabolism; D000328:Adult; D000758:Anesthesia / Q000009:adverse effects; D001463:Barbiturates / Q000009:adverse effects; D002746:Chlorpromazine / Q000627:therapeutic use; D003276:Contraceptives, Oral / Q000009:adverse effects; D005260:Female; D006418:Heme / Q000378:metabolism; D006584:Hexamethonium Compounds / Q000627:therapeutic use; D006801:Humans; D008099:Liver / Q000378:metabolism; D008297:Male; D008598:Menstruation; D011164:Porphyrias / Q000139:chemically induced / Q000188:drug therapy / Q000201:enzymology; D011166:Porphyrins / Q000378:metabolism; D011247:Pregnancy; D013329:Structure-Activity Relationship
chemical_list: D001463:Barbiturates; D003276:Contraceptives, Oral; D006584:Hexamethonium Compounds; D011166:Porphyrins; D006418:Heme; D000624:5-Aminolevulinate Synthetase; D002746:Chlorpromazine