Effect of smoking marihuana and of a high-nicotine cigarette on angina pectoris.
The purpose of this study was to determine the effect of smoking marihuana and of high-nicotine cigarettes on exercise-induced angina pectoris. Smoking 1 marihuana cigarette increased the resting product of systolic blood pressure times heart rate 54%, increased the venous carboxyhemoglobin level, and decreased the exercise time until angina 50% in 10 patients with angina pectoris. Smoking 1 high-nicotine cigarette increased the resting product of systolic blood pressure times heart rate 36%, increased the venous carboxyhemoglobin level, and decreased the exercise time until angina 23%. Smoking either marihuana or high-nicotine cigarettes decreases exercise performance until angina by increasing myocardial oxygen demand and by decreasing myocardial oxygen delivery. Smoking 1 marihuana cigarette decreased the exercise time until angina more than smoking 1 high-nicotine cigarette (p less than 0.001).
D000787:Angina Pectoris / Q000150:complications / Q000503:physiopathology*; D001794:Blood Pressure / Q000187:drug effects; D002188:Cannabis / Q000494:pharmacology*; D002263:Carboxyhemoglobin / Q000032:analysis; D003327:Coronary Disease / Q000150:complications / Q000503:physiopathology; D004562:Electrocardiography; D005080:Exercise Test; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D008297:Male; D008875:Middle Aged; D009538:Nicotine / Q000494:pharmacology*; D012907:Smoking / Q000150:complications*
D009538:Nicotine; D002263:Carboxyhemoglobin