The effect of actinomycin D on estrogen-induced uterine blood flow.
The effect of actinomycin D on estrogen-induced uterine blood flow was studied in four nonpregnant, oophorectomized sheep, utilizing electromagnetic flow probes chronically implanted around the uterine arteris. Two hours after the intravenous injection of 1 mug of estradiol-17beta per kilogram of body weight, incorporation of [3H]-uridine into RNA was two- to threefold higher (2.7 plus or minus 0.4 S.E.M.) in the control horn than the uterine horn that had received an intra-arterial injection of actinomycin D. Actinomycin D had no effect on the estrogen-induced increase in uterine blood flow.
D000818:Animals; D001158:Arteries; D002369:Castration; D003609:Dactinomycin / Q000494:pharmacology; D003864:Depression, Chemical; D055590:Electromagnetic Phenomena; D004958:Estradiol / Q000008:administration & dosage / Q000494:pharmacology*; D005260:Female; D049671:History, 18th Century; D012313:RNA / Q000096:biosynthesis; D012039:Regional Blood Flow / Q000187:drug effects; D012756:Sheep; D014316:Tritium; D014529:Uridine / Q000378:metabolism; D014599:Uterus / Q000098:blood supply*
D014316:Tritium; D003609:Dactinomycin; D004958:Estradiol; D012313:RNA; D014529:Uridine