title: [Characteristics of the immunomorphological substrate in secondary immunization as dependent on the functional state of the hypothalamic nuclei].
abstract: The authors traced the morphological and serological shifts occurring in secondary immunological response against the background of destruction of the posterior hypothalamic nuclei. It was revealed in experiments on rabbits that in primary and secondary immunization carried out against the background of bilateral coagulation of the posterior hypothalamic nucleus the secondary immunological response was reduced in comparison with control. Depression occurred both on account of reduction of the number of cells-precursors, and in connection with disturbances of differentiation of the antibody-forming cells. When the primary immunization was conducted against the background of the intact brain, and destruction of the posterior hyfothalamic nuclei preceded the secondary immunization there occurred a change in the number of cells-precursors involved in differentiation, without disturbance of the differentiation itself.
mesh_terms: D000818:Animals; D000907:Antibodies, Bacterial / Q000032:analysis; D000921:Antibody-Producing Cells / Q000166:cytology; D002454:Cell Differentiation; D004168:Diphtheria Toxoid / Q000008:administration & dosage; D005455:Fluorescent Antibody Technique; D007031:Hypothalamus / Q000276:immunology*; D007034:Hypothalamus, Posterior / Q000276:immunology* / Q000502:physiology; D007114:Immunization; D007117:Immunization, Secondary; D008198:Lymph Nodes / Q000166:cytology / Q000276:immunology; D011817:Rabbits; D013997:Time Factors
chemical_list: D000907:Antibodies, Bacterial; D004168:Diphtheria Toxoid
vernacular_title: Ob osobennostiakh immuno-morfologicheskogo substrata pri vtorichnoĭ immunizatsii v zavisimosti ot funktsional'nogo sostoianiia iader gipotalamusa