Effects of anesthetics on ponto-geniculo-occipital waves from the oculomotor nucleus of the cat.
Effects of anesthetics and doxapram on pontogeniculo-occipital (PGO) waves from the oculomotor nucleus were studied in acute experiments in cats paralyzed by gallamine triethiodide. The anesthetic agents studied in the present experiment (thiopental, ketamine, Innovar, nitrous oxide, and halothane) decreased, while doxapram increased, the total number of PGO waves. As the doses of anesthetics increased, PGO waves were abolished, but they returned to control levels or below control levels when the concentrations of anesthetics were decreased. The results indicate that the anesthetics studied inhibit the activity of the central mechanism associated with the oculomotor system. PGO waves may prove a useful index of the level of anesthesia.
D000769:Anesthesia, Inhalation; D000777:Anesthetics / Q000494:pharmacology*; D000818:Animals; D002415:Cats; D004315:Doxapram / Q000494:pharmacology; D004329:Droperidol / Q000494:pharmacology; D004569:Electroencephalography; D005133:Eye Movements; D005260:Female; D005283:Fentanyl / Q000494:pharmacology; D005829:Geniculate Bodies / Q000187:drug effects*; D006221:Halothane / Q000494:pharmacology; D006624:Hippocampus / Q000502:physiology; D007649:Ketamine / Q000494:pharmacology; D008297:Male; D009609:Nitrous Oxide / Q000494:pharmacology; D009778:Occipital Lobe / Q000187:drug effects*; D009802:Oculomotor Nerve / Q000187:drug effects / Q000502:physiology; D009900:Optic Nerve / Q000502:physiology; D011149:Pons / Q000187:drug effects*; D013477:Superior Colliculi / Q000187:drug effects* / Q000502:physiology; D013874:Thiopental / Q000494:pharmacology
D000777:Anesthetics; D007649:Ketamine; D004315:Doxapram; D013874:Thiopental; D009609:Nitrous Oxide; D004329:Droperidol; D005283:Fentanyl; D006221:Halothane