title: Biological markers in breast carcinoma. I. Incidence of abnormalities of CEA, HCG, three polyamines, and three minor nucleosides.
abstract: Patients with breast carcinoma were screened for abnormal concentrations of CEA, HCG, putrescine, spermidine, spermine, pseudouridine, N2, N2-dimethylguanosine, and 1-methylinosine. Abnormal polyamine levels occurred in less than 15% of the patients. Among the nucleosides, N2, N2-dimethylguanosine was the most frequently abnormal, occurring in 57% of the patients with metastatic disease. CEA levels were abnormal in 30% of postoperative N+ patients and 74% of patients with metastatic disease, while HCG elevations were found in 45% and 50%, respectively. All the patients with one or more marker abnormalities could be detected by measuring only CEA, N2, N2-dimethylguanosine, and HCG. Among these three tests, a singular marker abnormality occurred in 35.8% of the patients, and all three tests were abnormal in 21.8% of the patients. The performance of these three tests in each patient revealed one or more abnormalities 97% of the patients with metastatic disease, and 67% of the postoperative N+ patients.
mesh_terms: D001943:Breast Neoplasms / Q000097:blood / Q000276:immunology*; D002272:Carcinoembryonic Antigen / Q000032:analysis*; D006063:Chorionic Gonadotropin / Q000097:blood*; D005260:Female; D006151:Guanosine / Q000031:analogs & derivatives / Q000097:blood; D006801:Humans; D007288:Inosine / Q000031:analogs & derivatives / Q000097:blood; D009362:Neoplasm Metastasis; D009705:Nucleosides / Q000097:blood*; D011073:Polyamines / Q000097:blood*; D011560:Pseudouridine / Q000097:blood; D011700:Putrescine / Q000097:blood; D013095:Spermidine / Q000097:blood
chemical_list: D002272:Carcinoembryonic Antigen; D006063:Chorionic Gonadotropin; D009705:Nucleosides; D011073:Polyamines; D006151:Guanosine; D011560:Pseudouridine; D007288:Inosine; D013095:Spermidine; D011700:Putrescine