[Sensitivity and resistance of pathogenic yeasts to 5-fluoropyrimidines. I.--Relation between the phenotypes of resistance to 5-fluorocytosine, the serotype of Candida albicans and the ecology of various species of Candida of human origin (author's transl)].
The sensitivity to 5-fluorocytosine (5-FC), 5-fluorouracil (5-FU) and 5-fluorouridine (5-FUri) of 583 strains of C. albicans of human origin shows a relationship between their ecology, their serotype and their sensitivity to 5-FC. The incidence of the primary resistant strains isolated from patients with systemic candidiasis is of 4%, and 88.8% of the resistant strains belong to serotype B. In a closed community of premature infants the only resistant isolate amongst 78 strains recovered during hospitalization also belong to the B serotype and was introduced from outside. African strains of vaginal origin showed a higher incidence (21.6%) of resistance than did the european strains (4.5%) and this resistance was related to the B serotype predominant in the African environment. This raises the problem of the structure of the cell wall in connection with the active sites, the antigenic determinants and the enzymatic equipment.
D002175:Candida / Q000187:drug effects / Q000276:immunology*; D002176:Candida albicans / Q000187:drug effects / Q000276:immunology*; D003596:Cytosine / Q000031:analogs & derivatives*; D004352:Drug Resistance, Microbial; D005260:Female; D005437:Flucytosine / Q000494:pharmacology; D005472:Fluorouracil / Q000494:pharmacology*; D006801:Humans; D007231:Infant, Newborn; D007234:Infant, Premature; D011247:Pregnancy; D012703:Serotyping; D013045:Species Specificity; D014529:Uridine / Q000031:analogs & derivatives* / Q000494:pharmacology
D003596:Cytosine; D005437:Flucytosine; D005472:Fluorouracil; D014529:Uridine
Sensibilité et résistance des levures pathogènes aux 5-fluoropyrimidines. I.--Relation entre les phénotypes de résistance a la 5-fluorocytosine, le sérotype de Candida albicans et l'écologie de différentes espèces de Candida d'origine humaine