The role of plasma volume in the increase of aldosterone secretion rate during sodium deprivation.
1. 24 h aldosterone secretion rates (ASR) have been measured in six normal volunteers while recumbent all day and while standing for 12 h, on 200 and 10 mmol/day sodium diets and after salt-poor albumin infusions (75 g in 150 ml), which significantly expanded plasma volume. 2. The mean ASR on the 10 mmol/day sodium diet, both without and with the salt-poor albumin infusion, was highly significantly increased above the mean ASR on the 200 mmol/day sodium diet, both in the recumbent and in the upright posture. 3. There was no significant difference between the mean ASR values on the 10 mmol/day sodium diet alone and after the infusion of albumin either in the recumbent or in the upright posture. 4. The above abservations su;gest that sodium deprivation raises ASR by a mechanism or mechanisms unrelated to plasma volume.
D015065:17-Hydroxycorticosteroids / Q000652:urine; D000328:Adult; D000450:Aldosterone / Q000097:blood* / Q000378:metabolism; D001835:Body Weight; D003404:Creatinine / Q000652:urine; D004032:Diet; D005260:Female; D006801:Humans; D008297:Male; D010953:Plasma Volume / Q000187:drug effects*; D011187:Posture; D011188:Potassium / Q000097:blood / Q000652:urine; D012964:Sodium / Q000097:blood / Q000494:pharmacology* / Q000652:urine
D015065:17-Hydroxycorticosteroids; D000450:Aldosterone; D012964:Sodium; D003404:Creatinine; D011188:Potassium