Inhibition of rat spermatogenesis and seminiferous tubule growth after short-term and long-term administration of a monoamine oxidase inhibitor.
Seminiferous tubules from rats killed 24 hours after injection of pargyline, a monoamine oxidase inhibitor, did not grow well in tissue culture when compared to control tubules. Treated tubules showed severe tubular degeneration and loss of cellular detail after nine days in culture. Animals injected with pargyline for ten days had varying degrees of semi-niferous tubule degeneration with depletion of the spermatogenic elements. It is suggested that pargyline has a detrimental effect on spermatogenesis. Pargyline possibly acts by decreasing MAO levels which, in turn, may increase potentially damaging amines which may be responsible for the testicular damage.
D000311:Adrenal Glands / Q000187:drug effects; D000818:Animals; D046508:Culture Techniques; D003864:Depression, Chemical; D007553:Isotope Labeling; D007985:Leydig Cells / Q000166:cytology; D008297:Male; D008995:Monoamine Oxidase / Q000378:metabolism; D010293:Pargyline / Q000008:administration & dosage / Q000494:pharmacology*; D010870:Pineal Gland / Q000187:drug effects; D010902:Pituitary Gland / Q000187:drug effects; D011467:Prostate / Q000187:drug effects; D051381:Rats; D012669:Seminal Vesicles / Q000187:drug effects; D012701:Serotonin / Q000494:pharmacology; D013091:Spermatogenesis / Q000187:drug effects*; D013223:Statistics as Topic; D013737:Testis / Q000187:drug effects* / Q000201:enzymology; D013997:Time Factors
D012701:Serotonin; D010293:Pargyline; D008995:Monoamine Oxidase