[Increase in the time of conservation of contractility of glycerinated muscles exposed to subthreshhold concentrations of chemical agents].
The response of glycerinized frog muscles to the action of chemical agents at subthreshold concentrations was the same as that of living muscles. Preservation of contractility (up to 50--200% over the control time) in response to ATP was achieved by incubation of the muscle models in solutions of chloral hydrate (0.0038--0.015M), urethan (0.09--0.35M), urea (0.5M) and sodium chloride (0.035--0.070M). Concentrations of these agents were always about 15--45% of the toxicity threshold. The prolongation of the "survival time" is suggested to depend on changes in the contractile proteins of muscles.
D000818:Animals; D001001:Anura; D002697:Chloral Hydrate / Q000008:administration & dosage / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D005990:Glycerol / Q000494:pharmacology*; D066298:In Vitro Techniques; D009119:Muscle Contraction / Q000187:drug effects*; D012965:Sodium Chloride / Q000008:administration & dosage / Q000494:pharmacology; D013997:Time Factors; D014508:Urea / Q000008:administration & dosage / Q000494:pharmacology; D014520:Urethane / Q000008:administration & dosage / Q000494:pharmacology
D014520:Urethane; D002697:Chloral Hydrate; D012965:Sodium Chloride; D014508:Urea; D005990:Glycerol
Uvelichenie vremeni sokhraneniia sokratimosti glitserinizirovannykh myshts liagushki pod vozdeĭstviem khimicheskikh agentov podporogovoĭ kontsentratsii