Compatible transfusion therapy for paroxysmal cold hemoglobinuria.
Two children with paroxysmal cold hemoglobinuria (PCH) are described. Both cases were associated with cold-warm serum lysins having anti-Tja activity. Transfusion with compatible frozen-thawed red cells tided these children over the critical acute hemolytic phase of the syndrome. These are the first recorded examples of successful compatible transfusion therapy in PCH.
D001803:Blood Transfusion; D002675:Child, Preschool; D003080:Cold Temperature; D003165:Complement System Proteins / Q000032:analysis; D003298:Coombs Test; D006400:Hematocrit; D006454:Hemoglobins / Q000032:analysis; D006457:Hemoglobinuria, Paroxysmal / Q000175:diagnosis / Q000276:immunology / Q000628:therapy*; D006461:Hemolysis; D006358:Hot Temperature; D006801:Humans; D007104:Immune Adherence Reaction; D007518:Isoantibodies / Q000032:analysis; D008297:Male; D011485:Protein Binding
D006454:Hemoglobins; D007518:Isoantibodies; D003165:Complement System Proteins