Heparin-induced thrombocytopenia: confirmation of diagnosis with in vitro methods.
Profound thrombocytopenia developed in a patient during treatment with heparin for venous thrombosis. The platelet count increased toward normal when heparin administration was stopped, but fell abruptly when the drug was again given. Platelet aggregation occurred when heparin was added to the patient's platelet-rich plasma, or to normal platelets plus the patient's serum. This serum also effected release of 3H-serotonin from normal platelets. This pattern of aggregation was clearly different from that occasionally caused by heparin in a control population. The data is consistent with an effect of heparin on platelets, possibly mediated by on immune mechanism.
D000238:Adenoma, Chromophobe / Q000532:radiotherapy; D000244:Adenosine Diphosphate / Q000494:pharmacology; D000328:Adult; D000368:Aged; D001766:Blindness / Q000209:etiology; D001780:Blood Coagulation Tests; D001792:Blood Platelets / Q000276:immunology / Q000378:metabolism; D004837:Epinephrine / Q000494:pharmacology; D005654:Fundus Oculi / Q000473:pathology; D006493:Heparin / Q000009:adverse effects* / Q000627:therapeutic use; D006801:Humans; D008297:Male; D008875:Middle Aged; D010974:Platelet Aggregation / Q000187:drug effects; D011693:Purpura / Q000139:chemically induced; D011830:Radiation Effects; D012658:Sella Turcica / Q000528:radiation effects; D012701:Serotonin / Q000378:metabolism; D013921:Thrombocytopenia / Q000139:chemically induced*; D013924:Thrombophlebitis / Q000188:drug therapy; D014316:Tritium
D014316:Tritium; D012701:Serotonin; D000244:Adenosine Diphosphate; D006493:Heparin; D004837:Epinephrine