Endodermal sinus tumor: a report of two sustained remissions treated postoperatively with a combination of actinomycin D, 5-fluorouracil, and cyclophosphamide.
The literature reflects a poor prognosis for women with endodermal sinus tumor. Two women with this neoplasm, 1 having stage IA and the other stage IIB disease were treated for 1 year postoperatively with a combination of actinomycin-D, 5-fluorouracil, and cyclophosphamide. Each had therapy discontinued after a negative second laparotomy and 15 and 21 months later are without recurrence. It is suggested that this drug regimen is a benficial adjunct to surgery in the treatment of endodermal sinus tumor.
D000293:Adolescent; D000328:Adult; D003520:Cyclophosphamide / Q000008:administration & dosage* / Q000627:therapeutic use; D003609:Dactinomycin / Q000008:administration & dosage* / Q000627:therapeutic use; D004359:Drug Therapy, Combination; D005260:Female; D005472:Fluorouracil / Q000008:administration & dosage* / Q000627:therapeutic use; D006801:Humans; D007813:Laparotomy; D008649:Mesonephroma / Q000188:drug therapy*; D010051:Ovarian Neoplasms / Q000188:drug therapy*; D012075:Remission, Spontaneous; D013724:Teratoma / Q000188:drug therapy; D013997:Time Factors
D003609:Dactinomycin; D003520:Cyclophosphamide; D005472:Fluorouracil