title: Immune response to hepatitis B surface antigen.
abstract: A total of 69 persons were investigated for assessment of cell-mediated and humoral immunity to hepatitis B surface antigen (HBsAg). Three groups, each consisting of 20 normal persons, 20HBsAg carriers, and 20 convalescent hepatitis B patients, were studied for HBsAg, anti-HBs, and leukocyte migration inhibition with purified HBsAg. Sequential sampling if an additional group of nine acute hepatitis B patients defined the cellular and humoral immune response to HBsAg. The antigen was eliminated rapidly by mounting of cell-mediated immune response detectable for a limited period, followed by antibody response in relatively few patients moore than 3 months after clearance of circulating HBsAg.
mesh_terms: D000917:Antibody Formation; D002464:Cell Migration Inhibition; D002499:Centrifugation, Density Gradient; D003377:Countercurrent Distribution; D006385:Hemagglutination Inhibition Tests; D006509:Hepatitis B / Q000276:immunology*; D006510:Hepatitis B Antibodies / Q000032:analysis; D006511:Hepatitis B Antigens / Q000032:analysis*; D006801:Humans; D007111:Immunity, Cellular; D007122:Immunoelectrophoresis; D007962:Leukocytes / Q000276:immunology; D011863:Radioimmunoassay
chemical_list: D006510:Hepatitis B Antibodies; D006511:Hepatitis B Antigens