[The serum and uterine muscle concentrations of Cephradin and Cephalothin].
On the day of operation 2 grams of Cephradin was given intravenously to 33 patient and 2 grams of Cephalothin was given intravenously to 31 patients. At various time intervals, uterine tissue and serum was removed. The mean serum concentrations of Cephradin were 3 times higher and the mean tissue concentrations of Cephradin were 7-8 times higher than the corresponding concentrations of Cephalothin. Because of the difference in protein binding of the examined cephalosporins (Cephradin 6%, Cephalothin 60-65%) the difference for the antimicrobially active portion (Protein free portion) is even more favorable for Cephradin. The significance of these pharmacokinetic differences for the treatment are obvious.
D000328:Adult; D002511:Cephalosporins / Q000378:metabolism*; D002512:Cephalothin / Q000097:blood / Q000378:metabolism; D005260:Female; D006801:Humans; D007044:Hysterectomy; D007275:Injections, Intravenous; D008875:Middle Aged; D011485:Protein Binding; D013997:Time Factors; D014599:Uterus / Q000378:metabolism*
D002511:Cephalosporins; D002512:Cephalothin
Konzentration von Cephradin und Cephalothin in Serum und in der Uterusmuskulatur