[Passive immunization against rubella: studies on the effectiveness of rubella-immunoglobulin after intranasal infection with rubella vaccination virus].
The effectiveness of high-titre rubella immunoglobulin was tested on rubella-susceptible female juveniles or young adults after intranasal immunization with rubella strain RA 27/3, 20 ml of rubella immunoglobulin having been administered intramuscularly to 56 subjects at different times (1, 3 and 5 days) after the immunization. The effect was demonstrated by seroconversion and virus isolation from the throat. In the control subjects (26) the secroconversion was 96% and in 42% of subjects virus was demonstrated in the throat. Early administration of rubella immunoglobulin (up to three days after immunization) depressed the seroconversion rate to 55% and virus isolation rate to 17.5%. Later administration (five days after immunization) increased the conversion rate to 81%, the isolation rate to 31%. There were no serious side effects of the immunization and the injection of the immunoglobulin. The results indicate that on early administration of an adequate amount of high-titre rubella immunoglobulin a protective effect can be expected, although this favourable effect-obtained in the conditions of this study-cannot be unreservedly transposed to the situation in wild virus infections.
D000293:Adolescent; D000914:Antibodies, Viral / Q000032:analysis; D000917:Antibody Formation; D000956:Antigens, Viral; D002648:Child; D005260:Female; D005334:Fever / Q000209:etiology; D006261:Headache / Q000209:etiology; D006801:Humans; D007112:Immunity, Maternally-Acquired; D007136:Immunoglobulins / Q000032:analysis; D007592:Joint Diseases / Q000209:etiology; D009666:Nose; D012409:Rubella / Q000276:immunology* / Q000517:prevention & control; D012411:Rubella Vaccine / Q000008:administration & dosage* / Q000009:adverse effects; D012412:Rubella virus / Q000276:immunology* / Q000302:isolation & purification; D013997:Time Factors
D000914:Antibodies, Viral; D000956:Antigens, Viral; D007136:Immunoglobulins; D012411:Rubella Vaccine
Passive Rötelnprophylaxe. Untersuchungen zur Wirksamkeit von Rötelnimmunglobulin nach intranasaler Infektion mit Röteln-Impfvirus