Effect of clomiphene on the ponderal, histological and biochemical changes induced by stilbestrol and testosterone in the uterus of rats.
A comparative study on the effects of clomiphene on the stilbestrol- and testosterone-induced changes in the weight, histology and biochemical constituents of the uterus was undertaken. Clomiphene counteracted the stilbestrol-induced increase in the weight, and the absolute contents of the glycogen, protein and RNA of the uterus, possibly by competitive inhibition. It failed to prevent such changes induced by testosterone: on the contrary, there were some additive effects. The results of the present study indicate that the binding sites for the estrogen and the androgen in the uterus are different.
D000818:Animals; D002996:Clomiphene / Q000494:pharmacology*; D004054:Diethylstilbestrol / Q000494:pharmacology*; D005260:Female; D006003:Glycogen / Q000378:metabolism; D009929:Organ Size; D011506:Proteins / Q000378:metabolism; D012313:RNA / Q000378:metabolism; D051381:Rats; D012794:Sialic Acids / Q000378:metabolism; D013739:Testosterone / Q000494:pharmacology*; D014599:Uterus / Q000033:anatomy & histology / Q000187:drug effects / Q000378:metabolism*
D011506:Proteins; D012794:Sialic Acids; D002996:Clomiphene; D013739:Testosterone; D012313:RNA; D004054:Diethylstilbestrol; D006003:Glycogen