title: Tumor and normal tissue response to irradiation in vivo: variation with decreasing dose rates.
abstract: Continuous irradiation in vivo at dose rates ranging form 0.54 to 274 rads per minute was performed in mice using the EMT6 tumor, the gut clone system, and the bone-marrow CFU system. A progressive increase in D0 and decrease in ñ were seen with decreasing dose rates in the EMT6 tumor and the gut clone system. The D0 showed little change in the bone-marrow CFU system. These findings are related to the D2-D1 values obtained from split-dose experiments at conventional dose rates. The results do not fit the various mathematical models proposed for correlating the effects of continuous low-dose-rate irradiation and acute exposure.
mesh_terms: D000818:Animals; D001853:Bone Marrow / Q000528:radiation effects; D001854:Bone Marrow Cells; D002587:Cesium Isotopes; D002999:Clone Cells / Q000528:radiation effects; D004307:Dose-Response Relationship, Radiation; D005260:Female; D007413:Intestinal Mucosa / Q000528:radiation effects; D007583:Jejunum / Q000473:pathology / Q000528:radiation effects; D008325:Mammary Neoplasms, Experimental / Q000401:mortality / Q000532:radiotherapy*; D008433:Mathematics; D051379:Mice; D008807:Mice, Inbred BALB C; D008962:Models, Theoretical; D009368:Neoplasm Transplantation; D011830:Radiation Effects; D011868:Radioisotopes; D011878:Radiotherapy / Q000379:methods; D011879:Radiotherapy Dosage; D014184:Transplantation, Homologous
chemical_list: D002587:Cesium Isotopes; D011868:Radioisotopes