Attenuation of "acute" habituation by scopolamine in the black-tailed prairie dog (Cynomys ludovicianus).
The hypothesis after scopolamine attenuates habituation occurring within a training session as well as that occurring between training sessions was tested and confirmed. Scopolamine injections (.5 mg/kg) reduced spontaneous wheel running in the prairie dog. The same dosage did not affect the threshold for wheen running induced by electrical brain stimulation (EBS). Another experiment demonstrated that EBS-induced running declined during a 10-min. stimulation period and indicated that the decline was habituative since the response was repeatedly dishabituated. In a final experiment .5 mg/kg of scopolamine reduced habituation of EBS-induced wheel running during 10-min. sessions.
D000818:Animals; D001921:Brain / Q000187:drug effects / Q000502:physiology; D004558:Electric Stimulation; D005260:Female; D006185:Habituation, Psychophysiologic / Q000187:drug effects*; D009043:Motor Activity; D012377:Rodentia / Q000502:physiology*; D012601:Scopolamine / Q000494:pharmacology*; D013997:Time Factors
D012601:Scopolamine