A comparsion of the effects of prazosin and hydrallazine on blood pressure, heart rate and plasma renin activity in conscious renal hypertensive dogs.
Prazosin, a novel antihypertensive agent, and hydrallazine have been compared in renal hypertensive dogs. I.v. prazosin (0.1 mg/kg) produced greater falls in blood pressure than hydrallazine (1 mg/kg i.v.) but, in contrast to hydrallazine, did not cause any significant alteration in heart rate or plasma renin activity in these animals. When given orally, prazosin (0.1 mg/kg) produced falls in blood pressure equivalent to those observed with i.v. hydrallazine (1 mg/kg) again without significant tachycardia or plasma renin activation.
D000818:Animals; D000959:Antihypertensive Agents / Q000494:pharmacology*; D001794:Blood Pressure / Q000187:drug effects*; D004285:Dogs; D005663:Furans / Q000494:pharmacology; D006830:Hydralazine / Q000494:pharmacology*; D006977:Hypertension, Renal / Q000503:physiopathology*; D008297:Male; D010879:Piperazines / Q000494:pharmacology; D011799:Quinazolines / Q000494:pharmacology*; D011863:Radioimmunoassay; D012083:Renin / Q000097:blood*
D000959:Antihypertensive Agents; D005663:Furans; D010879:Piperazines; D011799:Quinazolines; D006830:Hydralazine; D012083:Renin