title: Acute and chronic effects of sulpride on serum prolactin and gonadotropin levels in castrated male rats (38581).
abstract: The effect of the acute or chronic administration of sulpiride on serum prolactin and gonadotropin levels was studied in castrated male rats. Sulpiride administered in acute intravenous injections induced a quick increase in serum prolactin levels and no significant changes in serum gonadotropins. The peak in serum prolactin was observed 30 min after the injection of sulpiride, with a decrease of serum prolactin levels at 60 and 120 min. The subcutaneous administration of sulpiride for 13 days induced a significant increase in serum prolactin levels at the end of the treatment, and no significant changes in serum FSH and LH levels.
mesh_terms: D000818:Animals; D002369:Castration; D003864:Depression, Chemical; D005640:Follicle Stimulating Hormone / Q000097:blood*; D007275:Injections, Intravenous; D007279:Injections, Subcutaneous; D007986:Luteinizing Hormone / Q000097:blood*; D008297:Male; D011388:Prolactin / Q000097:blood*; D051381:Rats; D013268:Stimulation, Chemical; D013469:Sulpiride / Q000008:administration & dosage / Q000494:pharmacology; D013737:Testis / Q000502:physiology; D013997:Time Factors
chemical_list: D013469:Sulpiride; D011388:Prolactin; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone