Antagonism of luteinizing hormone release and of ovulation by an analog of the luteinizing hormone-releasing hormone.
Two varients of LH-RH, less than Glu-D-Phe-Trp-D-Ala-Leu-Arg-Pro-Gly-NH2 (I) and less than Glu-D-Phe-Trp-Ser-Tyr-D-Ala-Leu-Arg-Pro-NHCH2CH3 (II), have been synthesized by solid-phase methods. Both peptides strongly inhibit the LH-RH induced secretion of LH in an in vitro assay; however, only I proved effective in preventing ovulation in the 4-day cycling rat.
D000818:Animals; D002478:Cells, Cultured; D003864:Depression, Chemical; D005260:Female; D007987:Gonadotropin-Releasing Hormone / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000494:pharmacology; D066298:In Vitro Techniques; D007986:Luteinizing Hormone / Q000037:antagonists & inhibitors* / Q000097:blood; D010060:Ovulation / Q000187:drug effects*; D010902:Pituitary Gland / Q000187:drug effects; D051381:Rats
D007987:Gonadotropin-Releasing Hormone; D007986:Luteinizing Hormone