Malaria, favism and glucose-6-phosphate dehydrogenase deficiency.
Although glucose-6-phosphate dehydrogenase deficient individuals may suffer (sometimes fatally) from favism, a high incidence of this trait occurs in many Mediterranean populations. This apparent paradox is explained on the basis of a synergistic interaction between favism and G-6-PD deficiency that provides increased protection against malaria compared to that of the G-6-PD deficiency alone. This relationship is analogous to that between various hemoglobins and malaria in that there is selection for a more severe trait if it provides more protection against malaria.
D005236:Favism / Q000235:genetics; D005955:Glucosephosphate Dehydrogenase Deficiency / Q000235:genetics; D008288:Malaria / Q000235:genetics; D012641:Selection, Genetic