Plasma phenytoin levels produced by various phenytoin preparations.
A cross-over study was conducted to compare the plasma phenytoin levels produced by different phenytoin preparations available in Australia. The preparations were found not to be equivalent, a liquid suspension product producing higher levels compared with capsule and tablet formulations. The clinical significance and possible explantation are discussed.
D000293:Adolescent; D000328:Adult; D001682:Biological Availability; D002214:Capsules; D002986:Clinical Trials as Topic; D006801:Humans; D008875:Middle Aged; D010316:Particle Size; D010672:Phenytoin / Q000008:administration & dosage / Q000097:blood*; D012995:Solubility; D013535:Suspensions; D013607:Tablets
D002214:Capsules; D013535:Suspensions; D013607:Tablets; D010672:Phenytoin