Malignant histiocytosis in a patient presenting with leukocytosis, eosinophilia, and lymph node granuloma.
A patient with malignant histiocytosis presented with a number of unusual features including fever, leukemoid reaction, and eosinophilia. Other confusing findings included lymph node biopsies which showed reactive changes, noncaseating granuloma, and atypical Reed-Sternberg cells. These features are compared with cases appearing in the literature. The course was rapidly progressive despite combination chemotherapy.
D000328:Adult; D000493:Allopurinol / Q000627:therapeutic use; D001344:Autopsy; D001856:Bone Marrow Examination; D003520:Cyclophosphamide / Q000627:therapeutic use; D004802:Eosinophilia / Q000209:etiology*; D004977:Ethambutol / Q000627:therapeutic use; D005260:Female; D006099:Granuloma / Q000209:etiology*; D006801:Humans; D007538:Isoniazid / Q000627:therapeutic use; D007964:Leukocytosis / Q000209:etiology*; D008198:Lymph Nodes / Q000473:pathology; D008206:Lymphatic Diseases / Q000175:diagnosis* / Q000188:drug therapy / Q000473:pathology; D008297:Male; D011241:Prednisone / Q000627:therapeutic use; D013307:Streptomycin / Q000627:therapeutic use; D014750:Vincristine / Q000627:therapeutic use
D014750:Vincristine; D000493:Allopurinol; D004977:Ethambutol; D003520:Cyclophosphamide; D007538:Isoniazid; D011241:Prednisone; D013307:Streptomycin