Increased lever pressing for amphetamine after pimozide in rats: implications for a dopamine theory of reward.
Low and high doses of a dopamine blocking agent had effects on lever pressing for intravenous amphetamine reward which resembled the effects of reward reduction and reward termination, respectively. Noradrenaline blockade had no such effects. A role in central mediation of reward perception is suggested for dopamine but not for noradrenaline.
D000661:Amphetamine; D000818:Animals; D003216:Conditioning, Operant / Q000187:drug effects*; D004298:Dopamine / Q000502:physiology*; D004305:Dose-Response Relationship, Drug; D008297:Male; D010646:Phentolamine / Q000494:pharmacology; D010868:Pimozide / Q000494:pharmacology*; D011433:Propranolol / Q000494:pharmacology; D051381:Rats; D012201:Reward
D010868:Pimozide; D011433:Propranolol; D000661:Amphetamine; D004298:Dopamine; D010646:Phentolamine