Prolapsed mitral valve associated with the Holt-Oram syndrome.
The association of hypoplastic thumb and atrial septal defect, (Holt-Oram syndrome) with a prolapsed mitrial valve is described. Recognition of this association adds further support to the concept that the prolapsed mitrial valve syndrome is not necessarily an isolated cardiac disorder but may be part of a more generalized heritable disorder of connective tissue.
D000015:Abnormalities, Multiple / Q000150:complications / Q000000981:diagnostic imaging; D000328:Adult; D000790:Angiocardiography; D006328:Cardiac Catheterization; D004452:Echocardiography; D005260:Female; D006228:Hand Deformities, Congenital; D006330:Heart Defects, Congenital / Q000235:genetics; D006337:Heart Murmurs; D006344:Heart Septal Defects, Atrial / Q000150:complications* / Q000235:genetics / Q000601:surgery; D006347:Heart Sounds; D006801:Humans; D008944:Mitral Valve Insufficiency / Q000150:complications* / Q000175:diagnosis; D013933:Thumb / Q000002:abnormalities