[Study of a group of families with high incidence of schizophrenia].
The pedigrees of six schizophrenics' families presenting a very high percentage of sick subjects, (near to 50%) are studied. The data obtained allow to think to an hereditary transmission of the mental disease, in these families, as an autosomal dominant character; the responsible gene may have a reduced penetrance and a variable expressivity. The comparison of these data with those obtained from other schizophrenics' families support the hypotesis of an unomogeneus genetic basis for schizophrenia and also the supposition that a severe mutation of the principal gene has occurred in the studied families.
D000293:Adolescent; D000328:Adult; D000368:Aged; D005799:Genes, Dominant; D006801:Humans; D008875:Middle Aged; D010375:Pedigree; D012557:Schizoid Personality Disorder / Q000235:genetics; D012559:Schizophrenia / Q000235:genetics*
Studio di un gruppo di famiglie ad alta incidenza di schizofrenia