Is the Negri body specific for rabies? A light and electron microscopical study.
Since first described by Negri in 1903, the Negri body has been regarded as a pathognomonic finding in signifying the presence of rabies encephalitis. Negri bodies (light microscope) were found in the brain of a patient with conclusive evidence against the presence of rabies encephalitis. This case provided the opportunity for a pertinent review of the literature in bringing the subject into a reasoned perspective. A definitive etiologic diagnosis of rabies requires the use of electron microscopical or immunofluorescent methods or both.
D001344:Autopsy; D001921:Brain / Q000382:microbiology*; D002675:Child, Preschool; D006801:Humans; D007181:Inclusion Bodies, Viral / Q000648:ultrastructure*; D008297:Male; D008854:Microscopy, Electron; D011689:Purkinje Cells / Q000382:microbiology; D011818:Rabies / Q000175:diagnosis*; D011820:Rabies virus / Q000648:ultrastructure*