title: Neonatal changes in renal blood flow distribution in puppies.
abstract: The intrarenal distribution of blood flow was studied in 31 newborn mongrel puppies from 18 h to 70 days using xenon washout and krypton autoradiography. Mean renal blood flow increased from 0.39 plus or minus 0.05 ml/g per min (SE) the 1st wk to 2.06 plus or minus 0.12 ml/g per min at 6 wk. During the 1st wk of life renal cortex was perfused homo-geneously at 0.88 plus or minus 0.19 ml/g per min (SE) and accounted for 35 plus or minus 4% of the renal blood flow. During the 2nd wk a narrow, rapidly perfused zone of outer cortex was identified which was perfused at 3.35 plus or minus 0.26 ml/g per min, received 19.53 plus or minus 5.05% of the total renal blood flow, and represented 15 plus or minus 4% of the mass of the total cortex. The inner cortex and outer medulla at this time received 53.40 plus or minus 4.12% of the flow at 1.07 plus or minus 0.08 ml/g per min. Outer cortical flow increased with age reaching adult values by about 6-10 wk when the rapidly perfused area represented 40 plus or minus 8% of the cortex. These changes are parallel to the results of previously reported studies with microspheres in newborn puppies and are compatible with the well established maturational changes noted in neonates of several species. They represent the first gas-washout studies in animals during the first 6 wk of life.
mesh_terms: D000367:Age Factors; D000818:Animals; D001345:Autoradiography; D001783:Blood Flow Velocity; D001794:Blood Pressure; D004285:Dogs; D007839:Functional Laterality; D006400:Hematocrit; D007668:Kidney / Q000098:blood supply* / Q000254:growth & development / Q000502:physiology; D007726:Krypton; D008954:Models, Biological; D011868:Radioisotopes; D012039:Regional Blood Flow; D012588:Scintillation Counting; D013997:Time Factors; D014980:Xenon Radioisotopes
chemical_list: D011868:Radioisotopes; D014980:Xenon Radioisotopes; D007726:Krypton