Repeated oral administration of coumaphos in sheep: effects on erythrocyte acetylcholinesterase and other constituents.
The effects of treating adult wethers with 2 or 4 mg of coumaphos/kg of body weight each day for 6 days were investigated. The smaller dose produced a gradual decrease of erythrocyte acetylcholinesterase (AChE) activity (to maximum average reduction of approximately 45%), but without the appearance of signs of toxicosis. The larger dose appeared to be toxic. Treatment with the drug did not seem to alter significantly the anticholinesterase effects of a 2nd treatment made 6 weeks later. Coumaphos did not significantly affect serum activities of aspartate aminotransferase (glutamic oxalacetic transaminase) or isocitrate dehydrogenase (ICD) and concentrations of serum sodium and plasma calcium. A marked decrease in blood serum potassium and an increase in plasma magnesium occurred in all wethers that died after treatment with coumaphos, whereas appreciable changes did not occur in the survivors of the treatment given 6 weeks earlier. Treatment of sheep with an intravenous injection of the organophosphorous compound trichlorfon, insufficient to produce a significant effect on erythrocyte cholinesterase activity, produced additive effects with those of coumaphos.
D000110:Acetylcholinesterase / Q000097:blood*; D000284:Administration, Oral; D000818:Animals; D001219:Aspartate Aminotransferases / Q000097:blood; D002118:Calcium / Q000097:blood; D003372:Coumaphos / Q000008:administration & dosage / Q000633:toxicity*; D004912:Erythrocytes / Q000201:enzymology*; D007306:Insecticides / Q000633:toxicity*; D007521:Isocitrate Dehydrogenase / Q000097:blood; D008274:Magnesium / Q000097:blood; D008297:Male; D011188:Potassium / Q000097:blood; D012756:Sheep / Q000097:blood*; D012757:Sheep Diseases / Q000139:chemically induced; D012964:Sodium / Q000097:blood; D013997:Time Factors; D014236:Trichlorfon / Q000008:administration & dosage / Q000633:toxicity
D007306:Insecticides; D012964:Sodium; D014236:Trichlorfon; D007521:Isocitrate Dehydrogenase; D001219:Aspartate Aminotransferases; D000110:Acetylcholinesterase; D008274:Magnesium; D003372:Coumaphos; D011188:Potassium; D002118:Calcium