Hemodynamic effects of isoflurane and halothane in patients with coronary artery disease.
In 12 patients undergoing saphenous vein coronary artery bypass operations, cardiovascular hemodynamics were studied in the awake state (control) and during anesthesia with isoflurane (inspired concentration, 1.24%, 7 patients) or with halothane (inspired concentration, 0.77%, 5 patients). Isoflurane anesthesia was accompanied by decreases of 19% in the cardiac index (Q), 19% in mean arterial pressure (AP), and 16% in heart rate (HR). Only the change in AP was statistically significant. Halothane anesthesia was accompanied by decreases in Q (28%), AP (22%), and HR (10%). The changes in Q and AP were significant. HR did not change significantly following the induction of anesthesia with either agent. The decrease in AP was similar with both agents, and, in this regard, neither agent was clearly superior for patients with occlusive coronary artery disease.
D000758:Anesthesia; D001784:Blood Gas Analysis; D001794:Blood Pressure / Q000187:drug effects; D002302:Cardiac Output / Q000187:drug effects; D002986:Clinical Trials as Topic; D001026:Coronary Artery Bypass; D003327:Coronary Disease / Q000503:physiopathology*; D006221:Halothane / Q000494:pharmacology*; D006339:Heart Rate / Q000187:drug effects; D006439:Hemodynamics / Q000187:drug effects*; D006801:Humans; D007530:Isoflurane / Q000494:pharmacology*; D008738:Methyl Ethers / Q000494:pharmacology*; D008875:Middle Aged
D008738:Methyl Ethers; D007530:Isoflurane; D006221:Halothane