Bioconversion of ribostamycin (SF-733). III. Formation, structure and synthesis of 3-N-carboxymethyl ribostamycin.
A new inactivated product of ribostamycin (SF-733), 3-N-carboxymethyl ribostamycin, was obtained from the broth of Streptomyces ribosidificus which was grown on a medium containing D-xylose. Detection and some biochemical mechanism of N-carboxymethylation were discussed, and structure of 3-N-carboxymethyl ribostamycin was proposed based on the chemical degradation and synthesis.
D000900:Anti-Bacterial Agents / Q000031:analogs & derivatives*; D055598:Chemical Phenomena; D002621:Chemistry; D008745:Methylation; D012271:Ribostamycin / Q000031:analogs & derivatives* / Q000302:isolation & purification / Q000378:metabolism; D013302:Streptomyces / Q000378:metabolism; D014994:Xylose / Q000378:metabolism
D000900:Anti-Bacterial Agents; D012271:Ribostamycin; D014994:Xylose