Activity of commerical fasciolicides in small laboratory mammals.
The activity is reported of 6 commerical fasciolicides and disophenol administered at doses of effective in sheep, against 6- and 12-week-old Fasciola hepatica in rats and rabbits and 6-week-old flukes in guinea pigs. Tests in rats and rabbits do not give a reliable indication of the activity of fasciolicides in sheep, but results with guinea pigs were closer to those in sheep. A comparison of the effective dose in rats and sheep indicates that tests in rats usually underestimate activity in sheep. The use of a simple egg count procedure in sheep to provide information on potential fasciolicides is described.
D000083:Acetanilides / Q000031:analogs & derivatives / Q000627:therapeutic use; D000818:Animals; D000871:Anthelmintics / Q000627:therapeutic use*; D001713:Biphenyl Compounds / Q000627:therapeutic use; D002722:Chlorobenzenes / Q000627:therapeutic use; D004341:Drug Evaluation; D005211:Fascioliasis / Q000188:drug therapy* / Q000662:veterinary; D006168:Guinea Pigs; D009570:Nitriles / Q000627:therapeutic use; D009596:Nitrophenols / Q000627:therapeutic use; D011817:Rabbits; D051381:Rats; D012457:Salicylamides / Q000627:therapeutic use; D012756:Sheep; D012757:Sheep Diseases / Q000188:drug therapy
D000083:Acetanilides; D000871:Anthelmintics; D001713:Biphenyl Compounds; D002722:Chlorobenzenes; D009570:Nitriles; D009596:Nitrophenols; D012457:Salicylamides