title: [Serum enzymatic activity in neuromuscular diseases].
abstract: In 200 patients with neuromuscular diseases the author studied malonic dehydrogenase and lactic dehydrogenase activity comparing it with the activity of serum creatine kinase and aldolase. A significant rise in the values of all these enzymes was found only in the Duchenne type of muscular dystrophy, in polymyositis, and less frequently in the limb-girdle type of muscular dystrophy. Raised activity of creatine kinase and sidolase was observed in mothers and sisters of patients with Duchenne type of dystrophy, in patients with non-progressive myopathy, periodic paralysis, amyotrophic lateral sclerosis and polyneuropathy. With progression of dystrophy the activity of these enzymes decreases.
mesh_terms: D000293:Adolescent; D000690:Amyotrophic Lateral Sclerosis / Q000175:diagnosis; D002648:Child; D002675:Child, Preschool; D004796:Clinical Enzyme Tests; D003402:Creatine Kinase / Q000097:blood*; D003937:Diagnosis, Differential; D005634:Fructose-Bisphosphate Aldolase / Q000097:blood*; D006801:Humans; D007770:L-Lactate Dehydrogenase / Q000097:blood; D008291:Malate Dehydrogenase / Q000097:blood; D009136:Muscular Dystrophies / Q000175:diagnosis; D009220:Myositis / Q000175:diagnosis; D009468:Neuromuscular Diseases / Q000175:diagnosis* / Q000235:genetics; D010088:Oxidoreductases / Q000097:blood*
chemical_list: D010088:Oxidoreductases; D007770:L-Lactate Dehydrogenase; D008291:Malate Dehydrogenase; D003402:Creatine Kinase; D005634:Fructose-Bisphosphate Aldolase
vernacular_title: Aktywność enzymatyczna surowicy w chorobach nerwowo-mieśniowych