title: Intragranular starch: comparison of starch USP and modified cornstarch.
abstract: Incorporation of starch USP or a modified cornstarch within the granules of several drug formulations was investigated. In general, the formulation containing the modified starch exhibited improved processing characteristics as well as improved tablet properties. A comparison of a granulated and a direct compression formulation of the same ingradients indicated that granulation of an active ingredient is not necessarily detrimental to its (pharmaceutical) availability.
mesh_terms: D000082:Acetaminophen; D001205:Ascorbic Acid; D001702:Biopharmaceutics; D002482:Cellulose; D002740:Chlorothiazide; D004295:Dihydroxyphenylalanine; D005079:Excipients; D006245:Hardness Tests; D007700:Kinetics; D008750:Methyldopa; D011312:Pressure; D011339:Probenecid; D012995:Solubility; D013213:Starch / Q000592:standards; D013607:Tablets / Q000592:standards
chemical_list: D005079:Excipients; D013607:Tablets; D000082:Acetaminophen; D008750:Methyldopa; D004295:Dihydroxyphenylalanine; D002740:Chlorothiazide; D002482:Cellulose; D013213:Starch; D011339:Probenecid; D001205:Ascorbic Acid