Immuno-fluorescent reactivity to anti-somatostatin in the gastro-intestinal mucosa of the dog.
Evidence is presented that somatostatin-containing cells are present in the gastro-intestinal tract of the dog. Thus immuno-fluorescent cells were detected by the use of antiserum to cyclic somatostatin. These cells were mainly encountered in the antral mucosa and in the neighbourhood of gastrin-producing cells. No cross reaction was observed between gastrin and somatostatin. It is suggested that locally produced somatostatin controls gastrin secretion, and, more generally, that somatostatin-containing cells, multifocally distributed, modulates secretion of a large number of glands.
D000818:Animals; D004285:Dogs; D005455:Fluorescent Antibody Technique; D005753:Gastric Mucosa / Q000032:analysis*; D005755:Gastrins / Q000032:analysis; D007413:Intestinal Mucosa / Q000032:analysis*; D013004:Somatostatin / Q000032:analysis*
D005755:Gastrins; D013004:Somatostatin