Divided attention performance of cannabis users and non-users following cannabis and alcohol.
The effects of delta9-tetrahydrocannabinol (delta9-THC) and alcohol, and their combination, on divided attention performance were compared for cannabis users and non-users of both sexes. Performance by all subjects was significantly impaired following 2.6 and 5.2 mg delta9-THC but not at blood alcohol concentrations of 48 and 96 mg/100 ml. The combined effect of the 2 drugs depended upon prior experience with cannabis. A synergistic action occurred in non-users while an antagonistic effect occurred in the group of users. Differences in the alcohol effects between users and non-users provided evidence of cross-tolerance between cannabis and alcohol.
D000328:Adult; D000435:Alcoholic Intoxication / Q000503:physiopathology; D001288:Attention / Q000187:drug effects*; D002188:Cannabis / Q000494:pharmacology*; D002986:Clinical Trials as Topic; D013759:Dronabinol / Q000494:pharmacology*; D004347:Drug Interactions; D004361:Drug Tolerance; D000431:Ethanol / Q000494:pharmacology*; D005260:Female; D006801:Humans; D008297:Male; D010919:Placebos
D010919:Placebos; D000431:Ethanol; D013759:Dronabinol