Inhibition of enzymatic reduction of delta 14-double bond of 5 alpha-cholesta-8,14-dien-3 beta-ol and 5 alpha-cholesta-7,14-dien-3 beta-ol by AY-9944.
AY-994 (trans-1,4-bis-(2-chlorobenzyl-aminomethyl) cyclohexane dihydrochloride), a potent inhibitor of the enzymatic reduction of the delta 7-double bond of delta 5,7-sterols, has been shown to inhibit, at higher concentrations (10-4 M), the enzymatic reduction of the delta 14-double bond of cholesta-8,14-dien-3 beta-ol and cholesta-7,14-dien-3 beta-ol.
D000818:Animals; D001593:Benzyl Compounds / Q000494:pharmacology; D002713:Chlorine / Q000494:pharmacology; D002775:Cholestadienols / Q000378:metabolism*; D003510:Cyclohexanes / Q000031:analogs & derivatives* / Q000494:pharmacology; D005260:Female; D008099:Liver / Q000187:drug effects / Q000201:enzymology*; D008744:Methylamines / Q000494:pharmacology; D010084:Oxidation-Reduction; D010088:Oxidoreductases / Q000037:antagonists & inhibitors*; D051381:Rats; D013329:Structure-Activity Relationship
D001593:Benzyl Compounds; D002775:Cholestadienols; D003510:Cyclohexanes; D008744:Methylamines; D002713:Chlorine; D010088:Oxidoreductases