Lactic dehydrogenase isoenzymes in human bladder cancer.
The lactic dehydrogenase isoenzymic patterns of normal, atypical and neoplastic urothelium were studied. In comparison to normal, the atypical urothelium had a significant increase in the LDH-V/I ratio. In neoplastic urothelium the LDH-I per cent was increased in low grade tumors, while the LDH-V per cent and LDH-V/I ratio was increased in high grade tumors. The findings in high grade tumors are thought to represent altered genetic expression with activation of the gene locus controlling M subunit synthesis.
D001706:Biopsy; D002295:Carcinoma, Transitional Cell / Q000201:enzymology* / Q000473:pathology; D006651:Histocytochemistry; D006801:Humans; D007527:Isoenzymes; D007770:L-Lactate Dehydrogenase / Q000378:metabolism*; D001743:Urinary Bladder / Q000201:enzymology* / Q000473:pathology; D001749:Urinary Bladder Neoplasms / Q000201:enzymology* / Q000473:pathology
D007527:Isoenzymes; D007770:L-Lactate Dehydrogenase