title: Correlation of anti-inflammatory activity with inhibition of prostaglandin synthesis activity of nonsteroidal anti-estrogens and estrogens (38532).
abstract: Diethylstilbestrol, clomiphene, ethamoxytriphetol and triparanol were 0.18, 1.0, 0.02 and 0.01 times as potent in the in vitro inhibition of prostaglandin synthetase, respectively as was indomethacin.  In the in vivo carrageenan-induced rat paw edema studies, diethylstilbestrol was more potent as an anti-inflammatory agent than was clomiphene, and ethamoxytriphetol and triparanol were only marginally effective.  The most potent of the compounds tested was indomethacin.  The results reported demonstrate that the nonsteroidal anti-inflammatory agents and the nonsteroidal estrogens and anti-estrogens share the property of inhibition of prostaglandin synthetase.
mesh_terms: D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology*; D002351:Carrageenan; D002996:Clomiphene / Q000494:pharmacology; D004048:Diethylamines / Q000494:pharmacology; D004054:Diethylstilbestrol / Q000494:pharmacology; D004965:Estrogen Antagonists; D004967:Estrogens / Q000494:pharmacology*; D000431:Ethanol / Q000031:analogs & derivatives / Q000494:pharmacology; D066298:In Vitro Techniques; D007213:Indomethacin / Q000494:pharmacology*; D007249:Inflammation / Q000139:chemically induced; D008297:Male; D010647:Phenyl Ethers / Q000494:pharmacology; D011453:Prostaglandins / Q000096:biosynthesis*; D051381:Rats; D012669:Seminal Vesicles / Q000378:metabolism; D014308:Triparanol / Q000494:pharmacology
chemical_list: D000893:Anti-Inflammatory Agents; D004048:Diethylamines; D004965:Estrogen Antagonists; D004967:Estrogens; D010647:Phenyl Ethers; D011453:Prostaglandins; D002996:Clomiphene; D000431:Ethanol; D014308:Triparanol; D004054:Diethylstilbestrol; D002351:Carrageenan; D007213:Indomethacin