Estimation of plasma diazepam. Critique of a method using gas-liquid chromatography and benzene extraction.
Plasma diazepam can be reliably estimated using a simple benzene extraction and gas-liquid chromatography with griseofulvin as internal standard. This gives reproducible results within the clinical range of plasma levels. Storage at minus 20 degrees C is recommended but is not essential for the 1st week.
D001554:Benzene; D001793:Blood Preservation; D002849:Chromatography, Gas / Q000379:methods*; D003975:Diazepam / Q000097:blood*; D005615:Freezing; D006118:Griseofulvin; D006801:Humans; D011229:Preanesthetic Medication; D013048:Specimen Handling
D006118:Griseofulvin; D001554:Benzene; D003975:Diazepam