title: 5-chloro-2-pyrimidinyl analog of dantrolene.
abstract: 1-[5-(5-Chloro-2-pyrimidinyl)furfurylidene]amino-hydantoin, a structural analog of the skeletal muscle contraction antagonist dantrolene, was synthesized and found to have no skeletal muscle relaxant activity.
mesh_terms: D000818:Animals; D002713:Chlorine / Q000494:pharmacology; D003620:Dantrolene / Q000031:analogs & derivatives / Q000138:chemical synthesis; D004305:Dose-Response Relationship, Drug; D006827:Hydantoins / Q000138:chemical synthesis*; D066298:In Vitro Techniques; D051379:Mice; D009119:Muscle Contraction / Q000187:drug effects; D009132:Muscles / Q000187:drug effects; D011743:Pyrimidines / Q000138:chemical synthesis* / Q000494:pharmacology; D051381:Rats
chemical_list: D006827:Hydantoins; D011743:Pyrimidines; D002713:Chlorine; D003620:Dantrolene