Prolongation of skin allograft survival by Valium (diazepam).
The survival of rat skin allografts was significantly increased by repeated intraperitoneal injections of 2.5 mg Valium (diazepam) into hosts. In addition, in vivo pretreatment of the donor animals at this dose level decreased the intensity of the recipients' immune responses to skin allografts. In vitro exposure of skin grafts to Valium also prolonged allograft survival.
D000818:Animals; D003975:Diazepam / Q000008:administration & dosage / Q000494:pharmacology*; D006084:Graft Rejection / Q000187:drug effects*; D007274:Injections, Intraperitoneal; D051381:Rats; D011917:Rats, Inbred Lew; D016038:Skin Transplantation; D014184:Transplantation, Homologous
D003975:Diazepam