[Pentacyclic triterpenes and ion excretion by rat kidneys].
Experiments were conducted on rats. A study was made of water, sodium, potassium and creatine excretion 3 hours after the administration into the stomach of a 5% load with a 0.9% NaCl solution. In comparison with control, sodium excretion decreased considerably in the animals given 2 mg per 100 g of weight of trioxylupane or heterobetulin; water, potassium and creatine excretion remained unchanged. Sodium and water excretion increased with administration of dioxylupenal in a dose of 2 mg per 100 g of weight. Heterobetulin also increased the urinary potassium excretion under conditions of administration to rats of a 5% load with a 1.25% KCl solution. The data obtained were of interest for the understanding of the interrelationship between the structure of the substances and their physiological activity.
D000818:Animals; D003401:Creatine / Q000378:metabolism; D004231:Diuresis / Q000187:drug effects; D005260:Female; D007668:Kidney / Q000378:metabolism*; D009318:Natriuresis / Q000187:drug effects*; D011188:Potassium / Q000378:metabolism*; D011189:Potassium Chloride / Q000378:metabolism; D051381:Rats; D012965:Sodium Chloride / Q000378:metabolism; D013268:Stimulation, Chemical; D014315:Triterpenes / Q000494:pharmacology*; D014882:Water-Electrolyte Balance / Q000187:drug effects*
D014315:Triterpenes; D012965:Sodium Chloride; D011189:Potassium Chloride; D003401:Creatine; D011188:Potassium
Pentstsiklicheskie triterpeny i ékskretsiia ionov pochkoĭ krysy