Degradation of particulate lipid by the large-granule fraction of rat liver (38555).
Radiolabeled particulate lipid administered intravenously was cleared from the circulation and localized primarily with in the liver. The phagocytized 131I-triglyceride was degraded with the subsequent release of free 131I-triglyceride emulsion in vitro with different hepatic subcellular fractions revealed that the lysosome rich large-granule fraction contained the highest specific deiodinative activity. This observation coupled with the findings on latency of activation and an acid findings on latency of activation and an acid pH optimum, support the concept that the lysosomes are critically involved in the degradation of the particulate phagocytized lipid in the liver.
D000818:Animals; D002458:Cell Fractionation; D007728:Kupffer Cells / Q000378:metabolism*; D008055:Lipids; D008099:Liver / Q000378:metabolism / Q000648:ultrastructure*; D008247:Lysosomes / Q000378:metabolism; D008297:Male; D012157:Mononuclear Phagocyte System / Q000502:physiology*; D010587:Phagocytosis; D051381:Rats; D014280:Triglycerides / Q000097:blood / Q000378:metabolism
D008055:Lipids; D014280:Triglycerides