title: Repair of cross-linked DNA in Escherichia coli.
abstract: The repair of DNA containing interstrand cross-links in Escherichia coli was studied by following the temporal sequence of DNA-related metabolic events in cells exposed to psoralen plus light. Mutations in some genes controlling replication, recombination, and repair strongly influence these specific events. Results reported here are consistent with a cross-link repair mechanism involving sequential excision and recombination.
mesh_terms: D001665:Binding Sites; D004260:DNA Repair / Q000187:drug effects; D004261:DNA Replication / Q000187:drug effects; D004269:DNA, Bacterial / Q000378:metabolism*; D004926:Escherichia coli / Q000187:drug effects / Q000378:metabolism*; D005363:Ficusin / Q000494:pharmacology; D008027:Light; D009690:Nucleic Acid Conformation
chemical_list: D004269:DNA, Bacterial; D005363:Ficusin