Studies on the sensitivity of anticancer agents of normal human cells in culture.
Two biopsies of human periosteal tissue have been tested for sensitivity to several antitumoral agents. The tests were performed during the lifespan of the cultured cells in order to reveal possible variations in sensitivity. The results indicate that the age of the donor affects drug sensitivity; cells obtained from the young donor show a higher growth potential, together with a variable sensitivity and morphology during their life in vitro, while cells from the adult donor have a lower growth potential, a constant sensitivity to chemotherapy and a constant morphology.
D000328:Adult; D000970:Antineoplastic Agents / Q000494:pharmacology / Q000592:standards*; D002470:Cell Survival; D002478:Cells, Cultured; D002648:Child; D003609:Dactinomycin / Q000494:pharmacology; D004317:Doxorubicin / Q000494:pharmacology; D005260:Female; D006801:Humans; D008297:Male; D008558:Melphalan / Q000494:pharmacology; D015122:Mercaptopurine / Q000031:analogs & derivatives / Q000494:pharmacology; D009588:Nitrogen Mustard Compounds / Q000494:pharmacology; D010521:Periosteum; D014228:Triaziquone / Q000494:pharmacology
D000970:Antineoplastic Agents; D009588:Nitrogen Mustard Compounds; D003609:Dactinomycin; D004317:Doxorubicin; D015122:Mercaptopurine; D014228:Triaziquone; D008558:Melphalan