Properties of enzymes. II. Comparative study of superoxide dismutase activity in rat tissues.
Consideration and comparison of specific superoxide dismutase activities shows that--of the values calculated for the same wet weight--the superoxide dismutase activity of the liver is more than twice that of the other tissues. This indicates the important metabolism-directing role of the liver. The large amount of superoxide dismutase (even the tissular superoxide dismutase alone) protects the tissues from the effects of the O(2)-radical, and the function of the superoxide dismutase probably opposing the cytochrome P-450 may be important as regards the hydroxylase effect.
D000818:Animals; D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism; D005260:Female; D005609:Free Radicals; D006801:Humans; D008099:Liver / Q000201:enzymology; D008297:Male; D009928:Organ Specificity; D010100:Oxygen; D051381:Rats; D013045:Species Specificity; D013482:Superoxide Dismutase / Q000378:metabolism*
D005609:Free Radicals; D003577:Cytochrome P-450 Enzyme System; D013482:Superoxide Dismutase; D010100:Oxygen