Cadmium accumulation in rat liver.
The biochemical accumulation and clinical pathological conditions induced by intraperitoneal administration of cadmium was studied in Sprague-Dawley rats. Injected doses of cadmium ranging from 0.5 to 3 mg/kg of body weight were administered. Distribution studies of Cd in the liver indicated the metal was bound to a soluble protein, and that the amount of metal present increases with increasing dosage. The pathological changes were found to correlate better with hepatic concentration of metal than with the injected dose.
D000818:Animals; D001835:Body Weight / Q000187:drug effects; D002104:Cadmium / Q000008:administration & dosage / Q000378:metabolism* / Q000633:toxicity; D056486:Chemical and Drug Induced Liver Injury / Q000209:etiology / Q000473:pathology; D002850:Chromatography, Gel; D007274:Injections, Intraperitoneal; D007770:L-Lactate Dehydrogenase / Q000378:metabolism; D008099:Liver / Q000187:drug effects / Q000378:metabolism* / Q000648:ultrastructure; D008297:Male; D008667:Metalloproteins / Q000378:metabolism; D009929:Organ Size; D011485:Protein Binding; D051381:Rats; D013054:Spectrophotometry, Atomic; D013347:Subcellular Fractions / Q000201:enzymology / Q000378:metabolism
D008667:Metalloproteins; D002104:Cadmium; D007770:L-Lactate Dehydrogenase