The correlation between the clinical effectiveness and ratio of blood concentration to minimum inhibitory concentration of sulfamethoxazole against Escherichia coli isolates. The determination of a parameter in a dosage equation by the pharmacokinetics.
The correlation between the clinical effectiveness and ratio of blood concentration to minimum inhibitory concentration of sulfamethoxazole against Escherichia coli isolated from clinical specimens were studied. This value is one of important parameters in a dosage equation by the pharmacokinetics, it showing sigma in an equation, were determined by clinical trial for acute simple cystitis of women. The sigma values were justified as 4 or more.
D000328:Adult; D001835:Body Weight; D003556:Cystitis / Q000188:drug therapy / Q000382:microbiology / Q000652:urine; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D004352:Drug Resistance, Microbial; D004926:Escherichia coli / Q000187:drug effects*; D005260:Female; D006801:Humans; D007700:Kinetics; D008826:Microbial Sensitivity Tests; D013420:Sulfamethoxazole / Q000008:administration & dosage / Q000378:metabolism / Q000494:pharmacology* / Q000627:therapeutic use; D014556:Urine / Q000382:microbiology
D013420:Sulfamethoxazole