An assessment of the reproducibility and safety of 2-deoxy-D-glucose as a gastric acid stimulant in duodenal ulcer patients.
In studying the effects of 2-deoxy-D-glucose (2-DG) on the vagus nerve in preoperative patients with duodenal ulcer we have concluded that (1) in initiating gastric acid secretion 2-DG produces a response that is reproducible after 30 days; (2) 2-DG when given in a dose of 40 mg/kg intravenously produces a glucopenic state that appears safe in an otherwise healthy patient. We consider that 2-DG is a worthwhile agent in the investigation of the duodenal ulcer patient.
D000410:Alanine Transaminase / Q000097:blood; D001219:Aspartate Aminotransferases / Q000097:blood; D001786:Blood Glucose; D001794:Blood Pressure / Q000187:drug effects; D001831:Body Temperature / Q000187:drug effects; D003837:Deoxy Sugars / Q000494:pharmacology*; D003847:Deoxyglucose / Q000009:adverse effects / Q000494:pharmacology*; D004381:Duodenal Ulcer / Q000175:diagnosis / Q000503:physiopathology*; D004562:Electrocardiography; D005750:Gastric Juice / Q000378:metabolism*; D011188:Potassium / Q000097:blood; D011674:Pulse; D012119:Respiration / Q000187:drug effects; D012636:Secretory Rate / Q000187:drug effects; D013268:Stimulation, Chemical
D001786:Blood Glucose; D003837:Deoxy Sugars; D003847:Deoxyglucose; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase; D011188:Potassium