The effect of pindolol on exercise-induced cardiac acceleration in relation to plasma levels in man.
The correlation between the beta receptor blocking activity of pindolol and plasma level was studied in 8 subjects after a 10-mg oral dose. Exercise tachycardia was markedly reduced over a period of at least 6 hr. Significant effects were recorded 30 min after the drug. For each individual there was a close correlation between log plasma level and beta blockade. The regression lines were parallel as shown by analysis of covariance; the intercepts, however, were significantly different. It can be concluded that there is a correlation between plasma level and beta adrenergic blockade by pindolol, but the data failed to establish in different individuals the blood levels necessary to achieve effective adrenergic blockade.
D000328:Adult; D000704:Analysis of Variance; D004562:Electrocardiography; D005080:Exercise Test; D005260:Female; D006339:Heart Rate / Q000187:drug effects*; D006801:Humans; D008297:Male; D005082:Physical Exertion; D010869:Pindolol / Q000097:blood / Q000494:pharmacology*; D012044:Regression Analysis; D013997:Time Factors
D010869:Pindolol