Renin and distal tubule Na during stop flow in dogs.
Using radioimmunoassay techniques, arteria (A) and renal venous (RV) plasma renin activities were measured in sodium pentobarbital-anesthetized dogs during clearance and stop-flow periods. Changes in RV-A renin were used to estimate changes in renin secretion. RV-A renin increased during stop flow from its average value during clearance periods, whether 10% mannitol in 0.15 M NaCl or 10% mannitol in 0.1 M Na2SO4 was being administered intravenously. However, RV-A renin during mannitol + NaCl stop-flow periods was significantly greater than during mannitol + Na2SO4 stop-flow periods. Distal tubular fluid Na concentrations as indicated by stop-flow analysis were higher during the latter. These observations suggest that a macula densa stimulus, Na concentration, and/or load, may control renin secretion during ureteral occlusion.
D000618:Aminohippuric Acids / Q000032:analysis; D000818:Animals; D001794:Blood Pressure; D001826:Body Fluids / Q000378:metabolism*; D004285:Dogs; D005260:Female; D007444:Inulin; D007684:Kidney Tubules / Q000502:physiology*; D007686:Kidney Tubules, Distal / Q000502:physiology; D007687:Kidney Tubules, Proximal / Q000502:physiology; D008297:Male; D008353:Mannitol; D008722:Methods; D011188:Potassium / Q000032:analysis; D012039:Regional Blood Flow; D012077:Renal Artery; D012082:Renal Veins; D012083:Renin / Q000378:metabolism*; D012964:Sodium / Q000032:analysis / Q000378:metabolism*; D012965:Sodium Chloride; D013431:Sulfates
D000618:Aminohippuric Acids; D013431:Sulfates; D008353:Mannitol; D012965:Sodium Chloride; D007444:Inulin; D012964:Sodium; D012083:Renin; D011188:Potassium