The genetics of Drosophila subobscura populations. V. A study of linkage disequilibrium in natural populations between genes and inversions of the E chromosome.
The genetics of Hk and Est-9 complex gene have been studied in Drosophila subobscura. While Hk alleles mendelize normally, Est-9 is a complex locus consisting of several very closely linked genes with active and silent alleles. Both genes are located on chromosome E; a detailed genetic map was constructed with the help of visible markers and inversions. Both Hk and Est-9 are included in or are very near to inversions of the E chromosome. While Hk does not show linkage disequilibrium either with Est-9 or inversions, Est-9 does show disequilibrium in two ways: both with inversions and between different Est-9 genes. All natural populations studied show the same kind of association between Est-9 gene combinations and inversions. It is argued that these results are better explained by selection than by neutrality.
D000483:Alleles; D000818:Animals; D002869:Chromosome Aberrations; D007446:Chromosome Inversion; D002874:Chromosome Mapping; D002875:Chromosomes; D004330:Drosophila / Q000201:enzymology; D004950:Esterases / Q000096:biosynthesis; D005260:Female; D005787:Gene Frequency; D005796:Genes; D008040:Genetic Linkage; D005828:Genetics, Population; D006593:Hexokinase / Q000096:biosynthesis; D008297:Male; D012641:Selection, Genetic
D006593:Hexokinase; D004950:Esterases