Inhibition of 5-hydroxytryptamine-induced human blood platelet aggregation by chlorpromazine and its metabolites.
1 Blood platelets from normal human subjects were isolated and aggregated in vitro with adenosine diphosphate (ADP) or 5-hydroxytryptamine (5-HT). 2 The effects of chlorpromazine and 7 major metabolites upon 5-HT-induced aggregation were investigated. 3 All the phenothiazines inhibited 5-HT-induced aggregation when added to platelet rich plasma 3 min prior to 5-HT. 4 There were no qualitative differences in the inhibitory effects, but inhibitory potency varied over a wide range. The decreasing order of potency was monodesmethylchlorpromazine, chlorpromazine, 7-hydroxychlorpromazine, didesmethylchlorpromazine, 3,7 -dimethoxy-chlorpromazine, didesmethylchlorpromazine sulphoxide, chlorpromazine sulphoxide, chlorpromazine nitroxide.
D000244:Adenosine Diphosphate / Q000494:pharmacology; D000293:Adolescent; D000328:Adult; D002746:Chlorpromazine / Q000031:analogs & derivatives / Q000494:pharmacology*; D005260:Female; D006801:Humans; D066298:In Vitro Techniques; D008297:Male; D010973:Platelet Adhesiveness / Q000187:drug effects*; D010974:Platelet Aggregation / Q000187:drug effects*; D012702:Serotonin Antagonists
D012702:Serotonin Antagonists; D000244:Adenosine Diphosphate; D002746:Chlorpromazine