Hypersensitivity of delayed type manifested during the development of allergic lesions of the myocardium.
Changes in humoral and cellular responses were studied during the development of allergic lesions of the myocardium in rabbits. These responses,manifestations of hypersensitivity of delayed type, are connected with transformation of cells of the active mesenchyme, responsible for the process of immuogenesis, into lymhocytes and plasma cells. In allergic lesions of the myocardium hypersensitivity of delayed type is manifested as lympho-marcrophagal reaction in the intermuscular stroma of the heart, the thymus, and lymph glands and also as blast transformation of the lymphocytes. A complex series of disturbances of immunologic homeostasis arises, in which the primary components are  micronaglopahies, blast-transformation of the lymphoctes and activation of iysosomal enzymes.
D000276:Adjuvants, Immunologic; D000818:Animals; D006968:Hypersensitivity, Delayed / Q000276:immunology*; D007111:Immunity, Cellular; D007114:Immunization; D008213:Lymphocyte Activation; D008264:Macrophages / Q000276:immunology; D009205:Myocarditis / Q000276:immunology*; D009206:Myocardium / Q000276:immunology; D011817:Rabbits; D051381:Rats / Q000276:immunology
D000276:Adjuvants, Immunologic