Recurrent hyperosmolar nonketotic episodes in a young diabetic.
A 15-month-old girl was successfully treated for substantial hyperosmolarity in the absence of ketosis at the onset of permanent insulin-requiring diabetes mellitus. Hypotonic solutions containing small amounts of glucose and subcutaneous administration of low doses of insulin were empolyed. Potassium was added to the hydrating solutions during the second hour of treatment. In the next three months, two recurrences of this syndrome were verified and successfully treated in a similar manner.
D001786:Blood Glucose / Q000032:analysis; D002712:Chlorides / Q000097:blood; D003681:Dehydration / Q000209:etiology*; D003922:Diabetes Mellitus, Type 1 / Q000150:complications* / Q000188:drug therapy; D003926:Diabetic Coma / Q000209:etiology*; D005260:Female; D005947:Glucose / Q000134:cerebrospinal fluid / Q000627:therapeutic use; D006801:Humans; D007223:Infant; D007328:Insulin / Q000097:blood / Q000627:therapeutic use; D007773:Lactates / Q000627:therapeutic use; D009994:Osmolar Concentration; D010634:Phenobarbital / Q000627:therapeutic use; D011188:Potassium / Q000097:blood; D011189:Potassium Chloride / Q000627:therapeutic use; D012008:Recurrence; D012964:Sodium / Q000097:blood / Q000627:therapeutic use
D001786:Blood Glucose; D002712:Chlorides; D007328:Insulin; D007773:Lactates; D011189:Potassium Chloride; D012964:Sodium; D005947:Glucose; D011188:Potassium; D010634:Phenobarbital