In vitro corticosteroid: correlation response with primary open-angle glaucoma and ocular corticosteroid sensitivity.
The transformation of human peripheral blood lymphocytes can be inhibited by corticosteroid compounds. In an in vitro study of 100 patients with primary open-angle glaucoma and various degrees of ocular pressure responsiveness to corticosteroid testing, varying degrees of sensitivity to corticosteroid compounds existed systemically in the circulating lymphocyte. A high correlation exists between the level of corticosteroid sensitivity in the lymphocyte and in the eye. In vitro cellular systems may be useful in evaluating the molecular basis of the variability in corticosteroid response, and in understanding the pathogenesis of corticosteroid-induced ocular hypertension and primary open-angle glaucoma.
D003864:Depression, Chemical; D003907:Dexamethasone / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D005901:Glaucoma / Q000503:physiopathology*; D006801:Humans; D006854:Hydrocortisone / Q000097:blood; D066298:In Vitro Techniques; D007429:Intraocular Pressure / Q000187:drug effects*; D037102:Lectins; D008213:Lymphocyte Activation / Q000187:drug effects; D009943:Organophosphorus Compounds / Q000494:pharmacology; D011239:Prednisolone / Q000032:analysis / Q000494:pharmacology
D037102:Lectins; D009943:Organophosphorus Compounds; D003907:Dexamethasone; D011239:Prednisolone; D006854:Hydrocortisone