title: Over 95 per cent sensitization against allogeneic leukocytes following single massive blood transfusion.
abstract: The development and persistence of leukoagglutinating and lymphocytotoxic alloantibodies were systematically studied in 54 patients who had received single massive blood transfusions because of open-heart surgery. Of these patients over 95% were sensitized when tested for both leukoagglutinins and lymphocytotoxins, whereas 74% were found to be immunized when searched for cytotoxic antibodies only. The optimal time for detecting antibodies was 2 weeks after blood transfusions.
mesh_terms: D000372:Agglutination Tests; D000917:Antibody Formation; D006348:Cardiac Surgical Procedures; D003601:Cytotoxicity Tests, Immunologic; D006650:Histocompatibility Testing; D006801:Humans; D007518:Isoantibodies / Q000032:analysis*; D007962:Leukocytes / Q000276:immunology; D065227:Transfusion Reaction
chemical_list: D007518:Isoantibodies