Variations in human metabolism of methaqualone given in therapeutic doses and in overdose cases studied by gas chromatography-mass spectrometry.
The individual variations in human metabolism of methaqualone were studied after oral administration of therapeutic doses. The effect of antabuse on the drug metabolism as well as metabolites in some autopsy cases were also studied. The metabolites were identified using the GC-MS computer technique, and the relative amounts of the indicated metabolites were calculated from the sum of the peak heights in the gas chromatogram. The results show that the individual variations were small in the cases of therapeutic doses and that antabuse did not interact with the metabolism of methaqualone. Large amounts of one single metabolite 2-methyl-3-[phenyl(2'-methyl-4-hydroxy)]-4(3H)-quinazolinone was found in the bile from the two autopsy cases where the bile was also collected.
D000284:Administration, Oral; D000328:Adult; D000368:Aged; D002849:Chromatography, Gas; D004221:Disulfiram / Q000494:pharmacology; D005260:Female; D006801:Humans; D008297:Male; D013058:Mass Spectrometry; D008702:Methaqualone / Q000008:administration & dosage / Q000378:metabolism* / Q000506:poisoning; D008722:Methods; D008875:Middle Aged
D008702:Methaqualone; D004221:Disulfiram