title: Microbial reduction of 1,3-dioxo-2-methyl-2-(3'0oxo-6'-carbomethoxyhexyl)-cyclopentane to form 1 beta-hydroxy-3-oxo-2beta-methyl-2alpha-(3'-oxo-6'-carbomethoxyhexyl)-cyclopentane, an intermediate for steroid total syntheses.
abstract: The rate and extent of stereoselective reduction of 1,3-dioxo-2-methyl-2-(3'-oxo-6'-carbomethoxyhexyl)-cyclopentane to form the 1beta-hydroxy-2beta-methyl isomer by cultures of Schizosaccharomyces pombe ATCC 2476 was dramatically increased by addition to the fermentation of certain alpha,beta-unsaturated ketones and allyl alcohol.
mesh_terms: D000438:Alcohols / Q000494:pharmacology; D001203:Ascomycota / Q000378:metabolism*; D055598:Chemical Phenomena; D002621:Chemistry; D002855:Chromatography, Thin Layer; D003517:Cyclopentanes / Q000032:analysis* / Q000096:biosynthesis; D005285:Fermentation; D007659:Ketones / Q000494:pharmacology; D013237:Stereoisomerism; D013256:Steroids / Q000096:biosynthesis
chemical_list: D000438:Alcohols; D003517:Cyclopentanes; D007659:Ketones; D013256:Steroids