A family study of coeliac disease.
Thirteen of 141 cases (9 percent) of overt, biopsy proven coeliac disease had a definitely affected relative. The pattern of inheritance in these families is compatible with an incompletely penetrant autosomal dominant gene. There was a female preponderance in the adults and the sporadic cases, but not in the children or the familial cases. The series included a pair of concordant and probably monozygotic twins. The authors believe that coeliac disease, as defined at present, is a heterogeneous condition.
D000293:Adolescent; D000328:Adult; D001706:Biopsy; D002446:Celiac Disease / Q000235:genetics*; D002648:Child; D004200:Diseases in Twins; D005260:Female; D005787:Gene Frequency; D005799:Genes, Dominant; D014644:Genetic Variation; D006801:Humans; D007583:Jejunum / Q000473:pathology; D008297:Male; D010375:Pedigree; D010641:Phenotype; D012641:Selection, Genetic; D012737:Sex Factors