title: Thyroid control of small intestinal oxygen consumption and the influence of sodium ions, oxyhen tension, glucose and anaesthesia.
abstract: 1. Oxygen consumption of jejunum removed from either killed or anaesthetized euthytoid, hypothyroid and triiodothyronine (T3)-treated rats was measured polarographically in vitro.  2. Hypothyroidism induced by drinking 6-n-propyl-2-thiouracil depressed jejunal oxygen consumption.  3. Treatment of euthyroid rats with T3 stimulated jejunal oxygen consumption by 39% in the presence of 28 mM glucose and by 23% in its absence.  4. Sodium ions appear to play a major permissive role in the action of T3 on jejunal oxygen uptake.  In the presence of sodium, T3 stimulated significantly the oxygen consumption by 23% while in the absence of sodium the stimulation was only 10% which was not significant.  The sodium-sensitive oxygen uptake of the jejunum was expanded by 57% after T3 treatment.
mesh_terms: D000768:Anesthesia, General; D000818:Animals; D005947:Glucose / Q000494:pharmacology*; D007037:Hypothyroidism / Q000139:chemically induced / Q000378:metabolism; D066298:In Vitro Techniques; D007421:Intestine, Small / Q000378:metabolism*; D007583:Jejunum / Q000187:drug effects / Q000378:metabolism; D008297:Male; D008564:Membrane Potentials; D010100:Oxygen; D010101:Oxygen Consumption / Q000187:drug effects*; D010313:Partial Pressure; D011441:Propylthiouracil; D051381:Rats; D012964:Sodium / Q000494:pharmacology*; D013268:Stimulation, Chemical; D013961:Thyroid Gland / Q000502:physiology*; D013965:Thyroidectomy; D014284:Triiodothyronine / Q000494:pharmacology
chemical_list: D014284:Triiodothyronine; D011441:Propylthiouracil; D012964:Sodium; D005947:Glucose; D010100:Oxygen