The occurrence of the HL-B alloantigens on the cells of unclassified acute lymphoblastic leukemias.
Six cases of acute lymphoblastic leukemia were studied by a variety of T- and B-lymphocyte surface markers. Two appeared to represent T-cell leukemias with the lymphoblasts forming sheep erythrocyte rosettes. The other four lacked all the usual membrane markers. However, indirect immunofluorescence with alloantisera detected the presence of the Ia-related HL-B antigens on the cells of the latter four cases; these antigens were absent in the first two cases. The primary association of the HL-B antigens with B cells raises the possibility that the positive group of cases are of B-cell lineage.
D001402:B-Lymphocytes / Q000276:immunology; D001666:Binding Sites, Antibody; D002462:Cell Membrane / Q000276:immunology; D005260:Female; D005455:Fluorescent Antibody Technique; D006649:Histocompatibility Antigens; D006801:Humans; D007140:Immunoglobulin Fab Fragments / Q000032:analysis; D007945:Leukemia, Lymphoid / Q000276:immunology*; D008214:Lymphocytes / Q000276:immunology; D008297:Male; D011247:Pregnancy; D013601:T-Lymphocytes / Q000276:immunology
D006649:Histocompatibility Antigens; D007140:Immunoglobulin Fab Fragments