Lymphocyte transformation in mycosis fungoides.
Lymphocyte transformation tests with PHA were carried out in 26 patients with mycosis fungoides (MF) in different stages of the disease. In premycotic and infiltrative stages of MF there were no significant disturbances in the lymphocyte response to PHA. Inhibition of DNA synthesis and blastic transformation was observed only in the tumorous stage. The results are in favour of the nosological distinctiveness of mycosis fungoides within the lymphoma group.
D000368:Aged; D001345:Autoradiography; D004247:DNA / Q000096:biosynthesis; D005500:Follow-Up Studies; D006801:Humans; D037102:Lectins / Q000032:analysis; D008213:Lymphocyte Activation; D008297:Male; D008875:Middle Aged; D009182:Mycosis Fungoides / Q000276:immunology* / Q000473:pathology / Q000532:radiotherapy; D011230:Precancerous Conditions / Q000276:immunology; D013936:Thymidine; D014316:Tritium
D037102:Lectins; D014316:Tritium; D004247:DNA; D013936:Thymidine