Anticonvulsant effects of 6-methoxy-1, 2, 3, 4-tetrahydro-alpha-carboline on audiogenic and electroconvulsive seizures in mice.
6-Methoxy-1, 2, 3, 4, -tetrahydro-beta-carboline (6-MeO-THBC) was tested for anticonvulsant properties against audiogenic seizures in DBA/2J and primed C57BL/6J mice (i.e., mice given a prior auditory exposure) and aginast electroconvulsive seizures in DBA/2J mice. 6-MeO-THBC (100 mg/kg) was found to attenuate both types of behavioral seizures 2 hr after injection as compared to saline controls. In addition, 6-MeO-THBC increased whole brain serotonin and decreased whole brain 5-hydroxyindoleacetic acid 2 hr after injection. These results support previous reports which suggest a serotonergic involvement in behavioral seizures.
D000161:Acoustic Stimulation; D000818:Animals; D000927:Anticonvulsants; D001522:Behavior, Animal / Q000187:drug effects; D001921:Brain / Q000187:drug effects / Q000378:metabolism; D002243:Carbolines / Q000494:pharmacology / Q000627:therapeutic use*; D004597:Electroshock; D005260:Female; D006897:Hydroxyindoleacetic Acid / Q000378:metabolism; D007211:Indoles / Q000627:therapeutic use*; D008297:Male; D008738:Methyl Ethers / Q000494:pharmacology / Q000627:therapeutic use; D051379:Mice; D008815:Mice, Inbred Strains; D012640:Seizures / Q000188:drug therapy*; D012701:Serotonin / Q000378:metabolism; D013045:Species Specificity; D013997:Time Factors
D000927:Anticonvulsants; D002243:Carbolines; D007211:Indoles; D008738:Methyl Ethers; D012701:Serotonin; D006897:Hydroxyindoleacetic Acid