Titrating dietary linoleate to in vivo platelet function in man.
Platelet aggregation time significantly increased within 48 hours in response to an increase in dietary linoleate of 4% of calories while disaggregation time decreased significantly in 96 hours. A change as small as 0.5% of calories was associated with significant alterations within 4 days. In this group, dietary linoleate appears to be related to platelet function by the equations Aggregation time equals 41.14 plus 2.79 linoleate Disaggregation time equals 11.04 minus 25.52 linoleate.
D000328:Adult; D002611:Cheese; D002784:Cholesterol / Q000097:blood; D004041:Dietary Fats / Q000008:administration & dosage*; D005224:Fats, Unsaturated / Q000008:administration & dosage; D005230:Fatty Acids, Nonesterified / Q000097:blood; D005260:Female; D006801:Humans; D008041:Linoleic Acids / Q000494:pharmacology*; D008055:Lipids / Q000097:blood; D008297:Male; D008383:Margarine; D010743:Phospholipids / Q000097:blood; D010973:Platelet Adhesiveness / Q000187:drug effects*; D010974:Platelet Aggregation / Q000187:drug effects*; D012450:Safflower Oil / Q000008:administration & dosage; D013997:Time Factors; D014280:Triglycerides / Q000097:blood
D004041:Dietary Fats; D005224:Fats, Unsaturated; D005230:Fatty Acids, Nonesterified; D008041:Linoleic Acids; D008055:Lipids; D010743:Phospholipids; D014280:Triglycerides; D012450:Safflower Oil; D008383:Margarine; D002784:Cholesterol