Pathophysiology of stress ulcer and its prevention. II. Prostaglandin E1 and microcirculatory responses in stress ulcer.
PGE1 completely prevented the formation of stress ulcers when administered in doses of 4 to 5 mg/kg or more. However, at this dose, complications and mortality were significant.
D000818:Animals; D004353:Drug Evaluation, Preclinical; D005753:Gastric Mucosa / Q000098:blood supply / Q000473:pathology; D008297:Male; D008833:Microcirculation / Q000187:drug effects* / Q000473:pathology; D011453:Prostaglandins / Q000008:administration & dosage / Q000627:therapeutic use*; D051381:Rats; D013270:Stomach / Q000098:blood supply* / Q000473:pathology; D013276:Stomach Ulcer / Q000209:etiology / Q000473:pathology / Q000503:physiopathology / Q000517:prevention & control; D013312:Stress, Physiological / Q000150:complications* / Q000473:pathology
D011453:Prostaglandins