Dehydration of tetracycline.
The dehydration of tetracycline at the C-5a-C-6 position as a function of acidity was investigated at various temperatures. The rate was first order with respect to tetracycline and with respect to [H+]. Rate constants and an activation energy are reported. Tetracycline was unstable in dilute acid.
D000812:Anhydrides / Q000138:chemical synthesis; D055598:Chemical Phenomena; D002621:Chemistry; D002855:Chromatography, Thin Layer; D007700:Kinetics; D013056:Spectrophotometry, Ultraviolet; D013696:Temperature; D013752:Tetracycline
D000812:Anhydrides; D013752:Tetracycline