Venous flow velocity, venous volume and arterial blood flow.
The relationship of arterial blood flow and venous volume to venous flow velocity was studied in normal subjects. The effects of current modes of treatment in venous thrombosis and of a vasodilator drug on venous flow velocity were also investigated. Total calf flow and venous volume were measured by venous occlusion plethysmography while venous flow axial velocity was determined by the transit time of 131-I albumin from calf to inguinal region. Local intravenous epinephrine administration induced venoconstriction and increased venous flow velocity. Intra-arterial isoproterenol and angiotensin increased and decreased arterial flow, respectively, with no change in venous flow velocity of volume, but local heat increased arterial flow and venous flow velocity with no change in venous volume. Local cold, despite venoconstriction, decreased venous flow velocity accompanied by a decreased arterial flow. Intravenous heparin did not affect venous flow velocity. Intravenous but not oral nylidrin increased venous flow velocity. Therefore venous flow velocity can be significantly increased by venocontriction, by large increases in arterial flow (local heat), and by a parenteral vasodilator drug. These experiements indicate that there is a basis for applying heat but not cold in the prevention and treatment of venous thrombosis.
D000328:Adult; D001158:Arteries / Q000502:physiology; D001783:Blood Flow Velocity; D001810:Blood Volume / Q000187:drug effects; D003097:Collateral Circulation; D017679:Cryotherapy; D004837:Epinephrine / Q000494:pharmacology; D006439:Hemodynamics / Q000187:drug effects; D006493:Heparin / Q000494:pharmacology; D006358:Hot Temperature / Q000627:therapeutic use; D006801:Humans; D007456:Iodine Isotopes; D007545:Isoproterenol / Q000494:pharmacology; D007866:Leg / Q000098:blood supply*; D011877:Radionuclide Imaging; D012039:Regional Blood Flow / Q000187:drug effects; D013924:Thrombophlebitis / Q000188:drug therapy / Q000517:prevention & control; D014680:Veins / Q000502:physiology; D014690:Venous Pressure
D007456:Iodine Isotopes; D006493:Heparin; D007545:Isoproterenol; D004837:Epinephrine