title: Corneal contact times of ophthalmic vehicles. Evaluation by microscintigraphy.
abstract: Lacrimal microscintigraphy, in conjunction with a recently developed computer system, was used to evaluate the corneal contact time of three ophthalmic vehicles in 18 humans. The percentage of a radioactively labeled vehicle remaining over the cornea after 90 seconds was 2.9% plus and minus 2.2% for saline, 4.3% plus and minus 2.4% for polyvinyl alcohol, and 8.8% plus and minus 4.1% for hydroxypropyl methylcellulose.
mesh_terms: D000328:Adult; D001693:Biological Transport, Active; D003201:Computers; D003315:Cornea; D005260:Female; D006801:Humans; D007765:Lacrimal Apparatus; D008297:Male; D008747:Methylcellulose / Q000378:metabolism; D009883:Ophthalmic Solutions; D009991:Oscillometry; D014677:Pharmaceutical Vehicles; D011142:Polyvinyl Alcohol / Q000378:metabolism; D011877:Radionuclide Imaging; D012965:Sodium Chloride / Q000378:metabolism; D013667:Technetium; D013997:Time Factors
chemical_list: D009883:Ophthalmic Solutions; D014677:Pharmaceutical Vehicles; D012965:Sodium Chloride; D013667:Technetium; D011142:Polyvinyl Alcohol; D008747:Methylcellulose