title: [Effect of nucleic acids on the outcome of acute streptococcal infection].
abstract: The work is devoted to the experimental study of the effect of exogenous heterologous RNA and DNA on the outcome of infection caused by streptococci--virulent and of low virulence, of the 1st and 2nd serological types of group A, in mice. It was found that the severity of the outcomes of the infectious process was not associated with the type of nucleic acids, but was determined by the dose and the periods of their administration in relation to the time of infection of the animals and the streptococcus virulence. Aggravation of the outcomes of the infection under the effect of exogenous RNA and DNA was accompanied by an increase in the virulence of the causative agent.
mesh_terms: D000208:Acute Disease; D000818:Animals; D004247:DNA / Q000008:administration & dosage / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D051379:Mice; D012313:RNA / Q000008:administration & dosage / Q000494:pharmacology*; D013290:Streptococcal Infections / Q000188:drug therapy*; D013297:Streptococcus pyogenes / Q000472:pathogenicity; D013997:Time Factors; D014774:Virulence / Q000187:drug effects
chemical_list: D012313:RNA; D004247:DNA
vernacular_title: Vliianie nukleinovykh kislot na iskhod ostroĭ streptokokkovoĭ infektsii