Identification of the vasopressin-neurophysin II and the oxytocin-neurophysin I producing neurons in the bovine hypothalamus.
Immuno-enzyme histochemical investigations on the bovine hypothalamus showed that vasopressin and oxytocin are synthetized in separate neurons. Moreover, it was found that the vasopressin-producing neurons are identical with the neruophysin II-producing neurons, while the oxtocin producing neurons correspond with the neurophysin I-producing neurons. From this result it is concluded that, in the species studied, neurophysin I is the carrier protein of oxytocin and that neurophysin II is the carrier protein of vasopressin. The bovine vasopressin-neurophysin II producing neurons and the oxytocin-neurophysin I producing neurons are both present as well in the suparoptic nuclei as in the paraventricular nuclei. In the supraoptic nuclei, the vasopressin-neurophysin II neurons predominate in number; in the paraventricular nuclei, the oxytocin-neurophysin II neurons predominate. The two kinds of bovine neurosecretory neurons are partly localized in separate areas. Moreover, the vasopressin-neurophysin II neurons and the oxytocin-neurophysin I neurons show distinct morphological differences.
D000818:Animals; D002417:Cattle; D006651:Histocytochemistry; D007031:Hypothalamus / Q000166:cytology* / Q000378:metabolism; D007106:Immune Sera; D009474:Neurons / Q000378:metabolism*; D009481:Neurophysins / Q000096:biosynthesis*; D010121:Oxytocin / Q000096:biosynthesis* / Q000276:immunology; D010544:Peroxidases / Q000276:immunology; D011817:Rabbits / Q000276:immunology; D014667:Vasopressins / Q000096:biosynthesis* / Q000276:immunology
D007106:Immune Sera; D009481:Neurophysins; D014667:Vasopressins; D010121:Oxytocin; D010544:Peroxidases