Linear regression analysis of inhibitory potency of organic disulfides against Histoplasma capsulatum.
The Free-Wilson equations are derived for the case of symmetrical substitution and are applied, in four modifications, to in vitro inhibitory activity of 77 organic disulfides against Histoplasma capsulatum. Substituent constants are listed to aid in the design of new inhibitory agents against this human pathogen (and perhaps other fungal organisms).
D004220:Disulfides / Q000494:pharmacology*; D006658:Histoplasma / Q000187:drug effects*; D007700:Kinetics; D008433:Mathematics; D008826:Microbial Sensitivity Tests; D008956:Models, Chemical; D012044:Regression Analysis; D013329:Structure-Activity Relationship
D004220:Disulfides