[Effects of propranolol on some metabolic changes induced with insulin].
The effect of propranolol on certain insulin-induced metabolic changes in man. The effects of 0.2 mg/kg/body weight propranolol perfused in 10' on insulin-induced (0.15 I.U./Kg i.v.)changes in blood glucose, pyruvate, lactic acid, phosphorus, and potassium levels were examined in 12 normal volunteers. The blood glucose curve was substantially unaffected. Insulin-induced increases in lactate and pyruvate were inhibited to a varying degree, namely 78% (61-93%) and 44% (0.94%) respectively. The fall in phosphorus was reduced in a more constant manner (mean 48; range 37-57%) in all subjects, while that of potassium was not altered. The data indicate that these insulin-induced changes are significantly, though variably, attributable to beta-adrenergic activity on the part of endogenous catecholamines released during insulin-induced hypoglycaemia.
D001786:Blood Glucose; D006801:Humans; D007328:Insulin / Q000494:pharmacology*; D007773:Lactates / Q000097:blood*; D010758:Phosphorus / Q000097:blood*; D011188:Potassium / Q000097:blood*; D011433:Propranolol / Q000494:pharmacology*; D011773:Pyruvates / Q000097:blood*
D001786:Blood Glucose; D007328:Insulin; D007773:Lactates; D011773:Pyruvates; D010758:Phosphorus; D011433:Propranolol; D011188:Potassium
Effetti del propranololo su alcune modificazioni metaboliche indotte dalla insulina