[New procedure in the diagnosis of maldigestion. Studies with 3-H palmitic acid and 14-C tripalmitate in normal subjects and patients with chronic pancreatitis].
3H-palmitic acid and 14C-tripalmitate dissolved in 1.0 g indian corn oil/kg body weight were administered to 29 patients with chronic pancreatitis and 25 control subjects. For the following 8 h 3H and 14C radioactivity in serum lipids and 14CO2 in expired air were measured at 2-hour intervals. Triglyceride absorption was significantly lowered in the pancreatitis group, while the wide dispersion in healthy subjects precluded reliable information on 14C-triglyceride absorption alone in individual cases. When related to palmitic acid absorption, however, reduced triglyceride absorption was much more evident and could be clearly demonstrated in 21 of the 29 patients with chronic pancreatitis. Since none of them had severe pancreatic insufficiency, the new double isotope method presented here appears to offer a very sensitive means of detecting maldigestion or slowed triglyceride hydrolysis. Compared with the 3H-fatty acid absorption, a relatively reduced triglyceride absorption was found in many cases without steatorrhea or otherwise demonstrable pancreatic insufficiency. Additional measurement of 14CO2 appears to be worthless, since in our patients specific activity of 14CO2 in the expired air was not reduced even in cases with mild steatorrhea.
D000328:Adult; D000368:Aged; D002250:Carbon Radioisotopes; D002908:Chronic Disease; D004063:Digestion; D006801:Humans; D006868:Hydrolysis; D008722:Methods; D008875:Middle Aged; D010169:Palmitic Acids / Q000378:metabolism; D010195:Pancreatitis / Q000175:diagnosis*; D014280:Triglycerides / Q000378:metabolism; D014316:Tritium
D002250:Carbon Radioisotopes; D010169:Palmitic Acids; D014280:Triglycerides; D014316:Tritium
Uber ein neues Verfahren in der Diagnostik der Maldigestion. Untersuchungen mit 3H-Palmitinsäure/14C-Tripalmitat bei Normalpersonen und Patienten mit chronischer Pankreatitis