title: Acute tolerance to ethanol in the rat.
abstract: Male Wistar rats were examined on the moving belt test at approximately 10, 30 and 60 min after administration of ethanol in doses ranging from 1.0-2.8 g/kg. Immediately after the test, each animal was sacrificed and ethanol concentrations were measured. The regression line of impairment as a function of brain alcohol concentration showed a progressive shift toward higher brain levels with increasing time after alcohol administration. The results confirm the existence of acute tolerance to ethanol, as defined by reduced impairment of function for a given blood level on the falling versus the rising arm of the blood alcohol curve. Confusion of interpretation due to arterio-venous differences in alcohol concentration was ruled out by simultaneous measurements in arterial blood and brain. Practice effects were ruled out by testing each animal only once.
mesh_terms: D000818:Animals; D001923:Brain Chemistry; D002540:Cerebral Cortex / Q000032:analysis; D004361:Drug Tolerance; D000431:Ethanol / Q000032:analysis / Q000097:blood / Q000494:pharmacology*; D008297:Male; D009048:Motor Skills / Q000187:drug effects; D051381:Rats; D012044:Regression Analysis
chemical_list: D000431:Ethanol