Elevated IGA in carcinoma of the nasopharynx.
Fourteen patients with nasopharyngeal carcinoma were evaluated immunologically prior to standard radiotion therapy. All had elevations of serum IgA, ranging from 300 mg/100 ml to 1000 mg/100 ml, with a mean value of 549 mg/100 ml. Seven patients demonstrated depression of cell-mediated immunity as measured by delayed hypersensitivity skin tests, total lymphocyte count, in vitro stimulation with PHA, and T-cell rosette formation. Elevation of serum IgA associated with depression of cell mediated immunity may be characteristic of patients with nasopharyngeal carcinoma.
D000917:Antibody Formation; D002277:Carcinoma / Q000276:immunology*; D006801:Humans; D006968:Hypersensitivity, Delayed; D007104:Immune Adherence Reaction; D007111:Immunity, Cellular; D007070:Immunoglobulin A / Q000032:analysis*; D037102:Lectins; D007958:Leukocyte Count; D008213:Lymphocyte Activation; D008214:Lymphocytes; D009303:Nasopharyngeal Neoplasms / Q000276:immunology*; D012882:Skin Tests
D007070:Immunoglobulin A; D037102:Lectins