Effects of phenobarbital on digitoxin and digoxin elimination in the dog.
When normal dogs were orally pretreated with a known microsomal enzyme inducer, phenobarbital, the serum biological half-life of digitoxin was not significantly affected, whereas the serum biological half-life of digoxin was significantly shortened by nearly 30%. These results are variant with that previously reported for human beings, wherein microsomal enzyme induction resulted in shortening of plasma biological half-life of digitoxin by more than 40% and insignificant effects on plasma biological half-life of digoxin. Because of the effect on plasma biological half-life, concomitant digoxin and phenobarbital administration to the canine cardiac patient may necessitate careful evaluation of the digitalization.
D000284:Administration, Oral; D000818:Animals; D004074:Digitoxin / Q000008:administration & dosage / Q000097:blood*; D004077:Digoxin / Q000097:blood*; D004285:Dogs / Q000378:metabolism*; D004347:Drug Interactions; D005260:Female; D006207:Half-Life; D007275:Injections, Intravenous; D008297:Male; D010634:Phenobarbital / Q000008:administration & dosage / Q000494:pharmacology*; D013997:Time Factors
D004077:Digoxin; D004074:Digitoxin; D010634:Phenobarbital