Immune response to combined live influenza virus vaccines administered intranasally.
The immune responses in volunteers vaccinated intranasally with a live influenza virus vaccine containing attenuated A and B strains have been studied. The hemagglutination-inhibiting antibody titers for both components were determined a few weeks after vaccination. They demonstrated that a good antibody response had been induced in a high percentage of volunteers. The hemagglutination inhibiting titers and percentage of seroconversion for both components were comparable to the results obtained after the intranasal administration of each component separately.
D000281:Administration, Intranasal; D000914:Antibodies, Viral / Q000032:analysis / Q000096:biosynthesis; D006385:Hemagglutination Inhibition Tests; D006801:Humans; D007109:Immunity / Q000187:drug effects*; D007252:Influenza Vaccines / Q000008:administration & dosage / Q000145:classification / Q000494:pharmacology*; D009500:Neutralization Tests; D014613:Vaccines, Attenuated
D000914:Antibodies, Viral; D007252:Influenza Vaccines; D014613:Vaccines, Attenuated