Cardiovascular malformations with lithium use during pregnancy.
The 143 cases of lithium use during pregnancy collected by the Register of Lithium Babies show that infants exposed to lithium appear to have a higher than expected ratio of cardiovascular anomalies to all anomalies and may have an increased risk of congenital heart disease. The authors believe that these findings justify a conservative policy on the use of lithium with fertile and pregnant women.
D000014:Abnormalities, Drug-Induced / Q000453:epidemiology*; D000328:Adult; D001017:Aortic Coarctation / Q000139:chemically induced; D001714:Bipolar Disorder / Q000188:drug therapy*; D002170:Canada; D002254:Carbonates; D002535:Cerebral Aqueduct / Q000002:abnormalities; D003718:Denmark; D004374:Ductus Arteriosus, Patent / Q000139:chemically induced; D004431:Ear, External / Q000002:abnormalities; D004437:Ebstein Anomaly / Q000139:chemically induced; D005260:Female; D005333:Fetus / Q000187:drug effects*; D006330:Heart Defects, Congenital / Q000139:chemically induced*; D006345:Heart Septal Defects, Ventricular / Q000139:chemically induced; D006352:Heart Ventricles / Q000002:abnormalities; D006801:Humans; D007231:Infant, Newborn; D008094:Lithium / Q000009:adverse effects* / Q000627:therapeutic use; D008943:Mitral Valve / Q000002:abnormalities; D011247:Pregnancy; D011248:Pregnancy Complications / Q000188:drug therapy*; D014188:Transposition of Great Vessels / Q000139:chemically induced; D014261:Tricuspid Valve / Q000002:abnormalities; D014481:United States; D014683:Vena Cava, Superior / Q000002:abnormalities
D002254:Carbonates; D008094:Lithium