Effect of neuraminidase on potency of inactivated influenza virus vaccines in mice.
The protective effect of neuraminidase was studied in a mouse protection test using isolated neuraminidase of A2/Aichi/68(H3N2) virus and the complete recombinant virus A/eq(Heq-1)-HK(N2) as antigens. Immunized mice were protected against A2/Aichi(H3N2) challenge virus; however, the protection rate was low in comparison to animals immunized with comparable amounts of the complete A2/68(H3N2) virus9 Furthermore there was no cross-protection against A2/Asia/57(H2N2) challenge virus. The protective effect of neuraminidase was not impaired by Tween-ether treatment of the A/eq(Heq-1)-HK(N2) recombinant virus.
D000818:Animals; D000917:Antibody Formation; D007252:Influenza Vaccines / Q000008:administration & dosage / Q000145:classification / Q000592:standards*; D051379:Mice; D009439:Neuraminidase / Q000008:administration & dosage / Q000276:immunology / Q000494:pharmacology*; D009975:Orthomyxoviridae / Q000201:enzymology; D009976:Orthomyxoviridae Infections / Q000276:immunology; D011136:Polysorbates / Q000494:pharmacology; D014611:Vaccination
D007252:Influenza Vaccines; D011136:Polysorbates; D009439:Neuraminidase