title: [Evaluation of the preventive efficacy of bonaphthone in influenza].
abstract: Bonaphthone was tested as a prophylactic drug in 4927 adults during 1973 influenza epidemic caused by influenza A/England/42/72 (H3N2) virus, and shown to exert a protective effect: the index of effectiveness was 1.8-2.9, the protection rate 44.7-66.4%. When given per os in a daily dose of 50 mg for 24 days bonaphthone produced no manifest side effects.
mesh_terms: D000284:Administration, Oral; D000293:Adolescent; D000328:Adult; D000917:Antibody Formation / Q000187:drug effects; D000998:Antiviral Agents / Q000627:therapeutic use*; D006801:Humans; D007251:Influenza, Human / Q000276:immunology / Q000517:prevention & control*; D008875:Middle Aged; D009285:Naphthoquinones / Q000008:administration & dosage / Q000627:therapeutic use*
chemical_list: D000998:Antiviral Agents; D009285:Naphthoquinones
vernacular_title: Otsenka profilakticheskoĭ éffektivnosti banaftona pri grippe.