title: Continuous phrophylcatic anticonvulsants in selected childrens with febrile convulsions.
abstract: The recurrence rate of febrile convulsions is assessed in 108 children who had had either prolonged or repeated initial fits or had both a positive family history and persisting neurological disorder. Only 7 of 40 (17%) who received continuous prophylactic phenobarbitone or primidone for at minimum of 18 months had another fit compared with 40 of 68 (59%) children who were untreated (p less than 0.0005). Indications for continuous therapy are discussed.
mesh_terms: D002648:Child; D002675:Child, Preschool; D002986:Clinical Trials as Topic; D005260:Female; D005334:Fever / Q000150:complications* / Q000188:drug therapy; D005500:Follow-Up Studies; D006801:Humans; D007223:Infant; D008297:Male; D010634:Phenobarbital / Q000627:therapeutic use*; D011324:Primidone / Q000627:therapeutic use*; D012008:Recurrence; D012640:Seizures / Q000188:drug therapy / Q000209:etiology / Q000517:prevention & control*
chemical_list: D011324:Primidone; D010634:Phenobarbital