title: [Significance of proteolytic sperm enzymes for the fertility].
abstract: Proteolytic enzymes of the male genital tract have important functions in the reproduction process. The sperm enzyme acrosin is of particular significance for the penetration of the zona pellucida. Proteinases are involved in coagulation and liquefaction of human semen. The kallikrein-kinin system has an important role in stimulation and regulation of sperm motility. In addition, semen proteinases seem to be involved in the penetration and migration of spermatozoa through the cervix uteri. Disturbances of the proteolytic potential of human semen may be the cause of subfertility or  infertility. Specific inhibition of proteinases participating in the fertilization process could be an approach for an effective antienzymatic contraception.
mesh_terms: D000176:Acrosin / Q000502:physiology; D002268:Carboxypeptidases / Q000494:pharmacology; D002582:Cervix Mucus; D003267:Contraception; D005260:Female; D005298:Fertility; D006801:Humans; D066298:In Vitro Techniques; D007248:Infertility, Male / Q000209:etiology; D007610:Kallikreins / Q000494:pharmacology / Q000502:physiology; D007705:Kinins / Q000494:pharmacology / Q000502:physiology; D008297:Male; D008855:Microscopy, Electron, Scanning; D010447:Peptide Hydrolases / Q000502:physiology*; D012661:Semen / Q000201:enzymology; D013073:Sperm Agglutination; D013081:Sperm Motility / Q000187:drug effects; D013084:Sperm-Ovum Interactions; D013094:Spermatozoa / Q000201:enzymology* / Q000648:ultrastructure; D014783:Viscosity
chemical_list: D007705:Kinins; D002268:Carboxypeptidases; D010447:Peptide Hydrolases; D007610:Kallikreins; D000176:Acrosin
vernacular_title: Die Bedeutung proteolytischer Spermaenzyme für die Fertilität