Response of the isolated perfused stomach of the dog to electrical vagal stimulation.
The left vagal trunk of blood-perfused, isolated, canine stomach was continously stimulated electrically for periods of 30 min at 7 v and 5-msec duration; the frequency of stimulation was varied without interruption from 0.5 to 10 Hz. Plasma immunoreactive gastrin (IRG), total gastric blood flow (GBF), and gastric acid output (GAO) were monitored continuously. When the vagus was stimulated, gastrin concentrations and GBF increased rapidly, while GAO rose at a slower rate. Two Hertz appeared to be the optimal stimulus frequency for increasing plasma IGR levels, while 10 Hz was most effective for increasing GBF. Increasing the frequency from 0 to 0.5 Hz produced the maximum observed change in GAO; additional increments to 2 or 10 Hz produced no consistent additional increase in GAO. The results indicate that plasma IRG concentration and GBF increase in response to various frequencies of vagal stimulation. Vagal stimulation increases the output of immunoreactive gastrin, as well as acid, from the isolated canine stomach.
D000818:Animals; D001769:Blood; D004285:Dogs; D004558:Electric Stimulation; D005750:Gastric Juice / Q000378:metabolism; D005755:Gastrins / Q000097:blood / Q000378:metabolism; D010477:Perfusion; D012039:Regional Blood Flow; D013270:Stomach / Q000098:blood supply / Q000502:physiology*; D013997:Time Factors; D014630:Vagus Nerve / Q000502:physiology*
D005755:Gastrins