title: Evidence of nonvagal neural stimulation of canine gastric acid secretion.
abstract: In this study, we confirmed our original findings that central vagus stimulation is significantly associated with a subsequent increase in gastric mucus secretion. Central vagus stimulation following phenoxybenzamine hydrochloride administration was associated significantly with protracted elevations in secretory volume and titratable acid. We were unable to conclude that phenoxybenzamine itself in several pharmacologic dosages was associated with an increase in titratable acid. The acid secretory responses could be abolished by transection of the splanchnic nerves. Electrical stimulation of the peripheral part of the splanchnic nerve following administration of phenoxybenzamine was also associated with significant increases in secretory volume and titrable acidity. These secretory responses were not blocked by atropine but were diminished by burimamide. It is concluded that, in the dog, a largely heretofore unsuspected second neural pathway exists which is capable of influencing gastric acid secretion.
mesh_terms: D000818:Animals; D001285:Atropine; D001794:Blood Pressure; D002049:Burimamide / Q000494:pharmacology; D002698:Chloralose; D003864:Depression, Chemical; D004285:Dogs; D004558:Electric Stimulation; D005260:Female; D005750:Gastric Juice / Q000378:metabolism*; D005753:Gastric Mucosa / Q000378:metabolism; D007649:Ketamine; D008297:Male; D010643:Phenoxybenzamine; D013153:Splanchnic Nerves / Q000502:physiology*; D013270:Stomach / Q000294:innervation*; D013997:Time Factors; D014520:Urethane; D014628:Vagotomy; D014630:Vagus Nerve / Q000502:physiology
chemical_list: D010643:Phenoxybenzamine; D002698:Chloralose; D014520:Urethane; D007649:Ketamine; D001285:Atropine; D002049:Burimamide