Radioselenium pancreozymin-secretin test as a clinical test for pancreatic exocrine function.
The appearance of radioselenium in the protein fraction of duodenal aspirates has been studied after an intravenous injection of 75-Se-selenomethionine. The continuous flow of pancreatic juice was stimulated by pancreozymin at 120 minutes and by secretin at 140 minutes. A good distinction between normal subjects and patients with pancreatic disease was obtained by measuring 75-Se-radioactivity in the protein fraction of duodenal aspirates; either cumulative radioactivity during the combined 80-minute post-pancreozymin-secretin period, or maximum 75-Se-specific activity during the postsecretin period was used as an index. The test presented here might be a useful and sufficiently reliable method for detecting abnormal pancreatic exocrine function. This test can be performed along with the conventional pancreozymin-secretin test, serum enzyme response to pancreozymin and secretin, and pancreatic scintiscanning.
D000681:Amylases / Q000097:blood; D002766:Cholecystokinin; D004386:Duodenum / Q000032:analysis; D006801:Humans; D010179:Pancreas / Q000378:metabolism / Q000502:physiology; D010181:Pancreatic Cyst / Q000175:diagnosis; D010182:Pancreatic Diseases / Q000175:diagnosis*; D010189:Pancreatic Juice / Q000378:metabolism; D010190:Pancreatic Neoplasms / Q000175:diagnosis; D010195:Pancreatitis / Q000175:diagnosis; D011877:Radionuclide Imaging; D012633:Secretin; D012643:Selenium; D012645:Selenomethionine
D012633:Secretin; D002766:Cholecystokinin; D012645:Selenomethionine; D000681:Amylases; D012643:Selenium