title: Glucocorticoid inhibition of sulfate incorporation by cartilage of normal rats.
abstract: The effects of dexamethasone, cortisol, and deoxycorticosterone on sulfate incorporation by cartilage of normal rats were determined. In vivo dexamethasone was a more potent inhibitor than cortisol, and deoxycorticosterone in the dose tested was ineffective. In vitro dexamethasone and cortisol were inhibitory in concentrations of 10-8 and 10-7M, respectively, when sulfate incorporation was measured after 24 h of incubation. Dexamethasone was at least 10 times as potent as cortisol. Deoxycorticosterone was inhibitory in a concentration of 10-4M. It is concluded that inhibition of mucopolysaccharide synthesis in cartilage of normal rats by adrenal cortical steroids or their analogs, both in vivo and in vitro, is correlated with glucocorticoid activity.
mesh_terms: D000818:Animals; D002356:Cartilage / Q000378:metabolism*; D003864:Depression, Chemical; D003900:Desoxycorticosterone / Q000494:pharmacology; D003907:Dexamethasone / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D005938:Glucocorticoids / Q000494:pharmacology*; D006854:Hydrocortisone / Q000494:pharmacology; D008297:Male; D051381:Rats / Q000378:metabolism*; D013431:Sulfates / Q000378:metabolism*; D013997:Time Factors
chemical_list: D005938:Glucocorticoids; D013431:Sulfates; D003900:Desoxycorticosterone; D003907:Dexamethasone; D006854:Hydrocortisone