Adequacy of commercial lentogenic vaccines against Canadian strains of viscerotropic Newcastle disease virus.
Three field strains of Newcastle Disease virus, designated S20, S21 and S23, isolated from chickens or turkeys in Ontario during the 1971-72 epizootic, were characterized as velogenic viscerotropic viruses. No significant antigenic differences were demonstrated among B1, LaSota and a field strain (S23) of velogenic vescerotropic virus by haemagglutination inhibition or protection tests. Primary water vaccination of chicks with commercial B1 and LaSota vaccines at five weeks of age and aerosol revaccination with the same strains four weeks later resulted in protection that lasted 16 weeks after revaccination against experimental challenge with strain S23. The differences in haemagglutination inhibition titres noted when the homologous or the heterologous viruses were used as haemagglutinating antigen were not statistically significant. The rates of decay of virus neutralizing and haemagglutination inhibition antibodies in vaccinated birds showed a divergence indicating the possible duality of antibodies measured in serum neutralization and haemagglutination inhibition tests.
D000284:Administration, Oral; D000336:Aerosols; D000818:Animals; D000917:Antibody Formation; D002170:Canada; D002645:Chickens; D006385:Hemagglutination Inhibition Tests; D009500:Neutralization Tests; D009521:Newcastle Disease / Q000276:immunology / Q000517:prevention & control*; D009522:Newcastle disease virus / Q000276:immunology*; D014765:Viral Vaccines / Q000008:administration & dosage; D014867:Water
D000336:Aerosols; D014765:Viral Vaccines; D014867:Water