Fatal infectious mononucleosis. Association with liver necrosis and herpes-like virus particles.
A 20-year-old woman died of infectious mononucleosis associated with extensive hepatic necrosis with herpes-type inclusions within nuclei of remaining liver cells. Electron microscopical examination of these liver cells showed intranuclear and occasional intracytoplasmic herpes-like virus. This case supports the concept that a herpes-like virus, or a structurally closely related agent, is the etiological agent of infectious mononucleosis.
D000328:Adult; D001344:Autopsy; D002467:Cell Nucleus / Q000382:microbiology / Q000648:ultrastructure; D002843:Chromatin; D003593:Cytoplasm / Q000382:microbiology / Q000648:ultrastructure; D005260:Female; D006801:Humans; D007181:Inclusion Bodies, Viral; D007244:Infectious Mononucleosis / Q000209:etiology / Q000382:microbiology* / Q000473:pathology; D008099:Liver / Q000382:microbiology* / Q000473:pathology / Q000648:ultrastructure; D008107:Liver Diseases / Q000382:microbiology* / Q000473:pathology; D008854:Microscopy, Electron; D009336:Necrosis
D002843:Chromatin