Increased serum bromide concentration after halothane anesthesia in man.
Seven healthy male volunteers received 6.6 plus or minus 0.5 (SE) per cent-hours of halothane-oxygen anesthesia without surgery. Serum bromide concentrations increased from 0.6 plus or minus 0.1 before anesthesia to 2.9 plus or minus 0.2 mEq/l on the second day after anesthesia. On the ninth day serum bromide was still elevated to 2.5 plus or minus 0.1 mEq/l. These bromide concentrations represent psychoactive levels and may account for previously recognized prolonged changes in mood and intellectual function after halothane. Plasma and urinary fluoride concentrations did not increase significantly.
D000328:Adult; D000769:Anesthesia, Inhalation; D001965:Bromides / Q000097:blood*; D005459:Fluorides / Q000097:blood / Q000652:urine; D006221:Halothane; D006801:Humans; D008297:Male; D013997:Time Factors
D001965:Bromides; D005459:Fluorides; D006221:Halothane