Cord blood coagulation studies in infants of high-risk pregnant women.
A prospective study of cord blood for coagulability, evidence for disseminated intravascular coagulation (DIC), and hematocrit was done in 106 infants who were offspring of mothers with high-risk pregnancies (pre-eclampsia, diabets mellitus, third-trimester bleeders, severe erythroblastosis fetalis, maternal hypertension, fetal distress, and spontaneous premature labor). Significant changes of hypercoagulability (low AT-III and abnormal TEG) were seen in the third-trimester bleeder and premature labor groups which also had the highest incidence of IRDS and necrotizing. Infants undergoing "stress" (pre-eclampsia, fetal distress) had elevated levels of factors V and VIII but were not hypercoagulable or AT-III deficient. Except for mild thrombocytopenia, infants of the diabetic mothers, a group with increased thrombotic complications, did not show any cord blood abnormalities. Offspring of third-trimester bleeders were anemic. The EBF infants were also anemic, severely hypercoagulable, and showed coagulation changes compatible with severe liver disease and/or DIC. Mild changes compatible with intravascular coagulation were seen in six infants and were not related to the the development of IRDS.
D000991:Antithrombins / Q000032:analysis; D001772:Blood Cell Count; D001777:Blood Coagulation; D001779:Blood Coagulation Factors / Q000302:isolation & purification; D001780:Blood Coagulation Tests; D001792:Blood Platelets; D004211:Disseminated Intravascular Coagulation / Q000175:diagnosis* / Q000209:etiology; D004461:Eclampsia / Q000097:blood / Q000150:complications; D004899:Erythroblastosis, Fetal / Q000097:blood; D005260:Female; D005315:Fetal Diseases / Q000209:etiology; D006400:Hematocrit; D006801:Humans; D006973:Hypertension / Q000097:blood / Q000150:complications; D007231:Infant, Newborn; D007232:Infant, Newborn, Diseases / Q000097:blood* / Q000209:etiology; D008431:Maternal-Fetal Exchange; D007752:Obstetric Labor, Premature / Q000097:blood / Q000150:complications; D011247:Pregnancy; D011248:Pregnancy Complications / Q000097:blood*; D011263:Pregnancy Trimester, Third; D011254:Pregnancy in Diabetics / Q000097:blood / Q000150:complications; D011446:Prospective Studies; D013916:Thrombelastography; D014470:Umbilical Cord; D014592:Uterine Hemorrhage / Q000097:blood / Q000150:complications
D000991:Antithrombins; D001779:Blood Coagulation Factors