Direct effect of prostaglandins in renal function and renin release in the presence of renal ischemia in the dog.
Prostaglandins PGE-1 or PGA-1 (0.5 to 1 mug per min) were infused into the stenosed renal artery of anesthetized hypertensive dogs. Increased urine volume, sodium and potassium excretion, and p-aminohippurate clearance were found during the prostaglandin infusion period in the infused kidney as compared to the control periods before infusion. Creatinine clearance was increased during infusion of PGE-1. The noninfused, nonischemic kidney showed no effect at the time of infusion with PGE-1 but in the case of PGA-1, the p-aminohippurate and creatinine clearances and urine diuresis were decreased. As a result, the mean aortic blood pressure decreased. Both prostaglandins increased the renal vein renin in the infused kidney. PGA-1 did affect renin release of the noninfused kidney, but PGE-1, which is rapidly inactivated by the lung, did not have this effect. Renin release seems to be influenced by electrolyte diuresis operating through the macula densa mechanism. However, the lowering of blood pressure seen in this study cannot exclude the involvement of the stretch receptors (the juxtaglomerular cells) for renin release. The increased renin release after prostaglandin administration seems to be a protective renal mechanism against the drug-induced hypotension. It seems to be induced by the direct sodium and water diuretic effects of prostaglandins.
D000818:Animals; D001794:Blood Pressure; D004231:Diuresis; D004285:Dogs; D005260:Female; D007511:Ischemia / Q000503:physiopathology; D007668:Kidney / Q000187:drug effects / Q000201:enzymology / Q000503:physiopathology*; D007677:Kidney Function Tests; D008297:Male; D009318:Natriuresis; D011188:Potassium / Q000652:urine; D011453:Prostaglandins / Q000494:pharmacology*; D012078:Renal Artery Obstruction / Q000503:physiopathology*; D012083:Renin / Q000378:metabolism*; D014882:Water-Electrolyte Balance
D011453:Prostaglandins; D012083:Renin; D011188:Potassium