Prevention of Ozonide-Induced Heinz Bodies in human Erythrocytes by Vitamin E.
Methyl oleate ozonide, a proposed intermediary in ozone intoxication, produced Heinz  body inclusions in human erythrocytes at concentrations of from 10-4 to 2 x 10-3 M. Daily oral supplementation with either 100 mg or 200 mg of D-alpha-tocopheryl acetate prevented Heinz body formation by methyl oleate ozonide. These observations suggest that the protective effects of vitamin E against ozone-produced toxicants occurs in man as well as in animals.
D004781:Environmental Exposure; D004912:Erythrocytes / Q000187:drug effects / Q000378:metabolism*; D005260:Female; D006366:Heinz Bodies / Q000187:drug effects*; D006801:Humans; D008297:Male; D009829:Oleic Acids / Q000506:poisoning; D010126:Ozone / Q000506:poisoning*; D014810:Vitamin E / Q000008:administration & dosage / Q000494:pharmacology*
D009829:Oleic Acids; D014810:Vitamin E; C010235:methyl oleate ozonide; D010126:Ozone