Cell cycle dependency of a T-cell marker on lymphoblasts.
A T-cell marker was expressed by the leukemic lymphoblasts of a 14 years old boy. After 14 days of cultivation, a permanently growing lymphoblastic cell line JM, which manifested the T-cell marker over the whole period of subcultivation, was established from the blood. In vitro synchronization experiments showed that this important cell marker in the G1 phase of the cell cycle is expressed on the surface of the blasts to a reduced degree, compared to the level in the other cell cycle phases.
D000293:Adolescent; D002455:Cell Division; D002460:Cell Line; D046508:Culture Techniques; D005455:Fluorescent Antibody Technique; D006801:Humans; D007945:Leukemia, Lymphoid / Q000473:pathology; D008297:Male; D013601:T-Lymphocytes; D013997:Time Factors