The effect of porphyrin precursors on monosynaptic reflex activity in the isolated hemisected frog spinal cord.
The porphyrin precursors beta-aminolevulinic acid (beta-ALA) and porphobilinogen (PBG) which accumulate, and are excreted in the urine in increased amounts during acute attacks of porphyria, were tested for their effects on reflex activity in the isolated hemisected spinal cords of Xenopus laevis. The two compounds were found to exert an inhibitory effect on monosynaptic ventral root responses, as well as on dorsal root responses (DRR) and dorsal root potentials (DRP). The latent period for inhibition of the monosynaptic response was longer than that for the DRR and DRP. The sensitivity of the preparations to the effect of the porphyrin precursors was subject to some seasonal variation. BETA-ALA and PBG did not effect conduction in isolated sciatic nerves at a concentration of 1 mg/ml.
D000622:Aminolevulinic Acid / Q000494:pharmacology*; D000818:Animals; D003864:Depression, Chemical; D005071:Evoked Potentials / Q000187:drug effects; D066298:In Vitro Techniques; D007982:Levulinic Acids / Q000494:pharmacology*; D009431:Neural Conduction / Q000187:drug effects; D011162:Porphobilinogen / Q000494:pharmacology*; D012023:Reflex, Monosynaptic / Q000187:drug effects*; D012584:Sciatic Nerve / Q000187:drug effects; D012621:Seasons; D013116:Spinal Cord / Q000502:physiology*; D013126:Spinal Nerve Roots / Q000187:drug effects; D014981:Xenopus
D007982:Levulinic Acids; D011162:Porphobilinogen; D000622:Aminolevulinic Acid