Pressure changes in bottles during sterilization by autoclaving.
A method is described to measure changes in pressure inside a bottle during autoclaving without disturbing the integrity of the seal. Experiments showed that, in a perfectly sealed bottle, the pressure rose to a maximum of 58.2 psi absolute. If the rubber linear was unable to maintain the seal, air leaked slowly from the bottle both during the heating-up and the early sterilization period.
D004349:Drug Packaging; D011199:Potentiometry; D011312:Pressure; D013242:Sterilization / Q000379:methods; D013696:Temperature; D013997:Time Factors