Antiallergic activity of 4-hydroxy-3-nitrocoumarins.
Twenty-four substituted 4-hydroxy-3-nitrocoumarins have been prepared for nitration of the corresponding 4-hydroxycoumarins. All were found to possess antiallergic activity as measured by the homocytotropic antibody-antigen induced passive cutaneous anaphylaxis reaction in the rat.
D000818:Animals; D000937:Antigen-Antibody Reactions; D003374:Coumarins / Q000138:chemical synthesis* / Q000627:therapeutic use; D006967:Hypersensitivity / Q000188:drug therapy*; D007111:Immunity, Cellular; D007518:Isoantibodies; D009574:Nitro Compounds / Q000138:chemical synthesis / Q000627:therapeutic use; D010323:Passive Cutaneous Anaphylaxis; D051381:Rats
D003374:Coumarins; D007518:Isoantibodies; D009574:Nitro Compounds