Determination of propoxyphene and norpropoxyphene by chemical ionization mass fragmentography.
The kinetics of propoxyphene and its primary metabolite, norpropoxyphene, have been simultaneously re-evaluated in man by using gas-liquid chromatography/mass spectrometry, deuterium-labeled mass internal standards, and multiple ion monitoring. Plasma concentrations in 4 volunteers determined for as long as 240 hr after single oral doses of 2 propoxyphene salts indicate the overall half-life of propoxyphene to be 11.8 hr and of norpropoxyphene to be 36.6 hr.
D000328:Adult; D002849:Chromatography, Gas; D003640:Dealkylation; D003903:Deuterium; D011431:Dextropropoxyphene / Q000031:analogs & derivatives / Q000032:analysis* / Q000097:blood; D006207:Half-Life; D006801:Humans; D008297:Male; D013058:Mass Spectrometry / Q000379:methods; D013997:Time Factors
D003903:Deuterium; D011431:Dextropropoxyphene