Tumor response in strain A mice exposed to silylating compounds used for gas-liquid chromatography.
Six reagents used to silylate, alkylate, or acylate compounds for ease of identification on gas chromatographic columns significantly increased the frequency of lung tumors in A/He mice.
D000081:Acetamides; D000236:Adenoma / Q000139:chemically induced*; D000477:Alkylating Agents / Q000633:toxicity*; D000818:Animals; D002849:Chromatography, Gas; D005260:Female; D007093:Imidazoles; D007202:Indicators and Reagents / Q000633:toxicity; D008175:Lung Neoplasms / Q000139:chemically induced*; D008297:Male; D051379:Mice; D008805:Mice, Inbred A; D009374:Neoplasms, Experimental / Q000139:chemically induced; D012825:Silicon / Q000633:toxicity*; D014226:Triazenes
D000081:Acetamides; D000477:Alkylating Agents; D007093:Imidazoles; D007202:Indicators and Reagents; D014226:Triazenes; D012825:Silicon