Hyperglycemia and gluconeogenesis in the liver of mice with tumors.
Gluconeogenesis, when sharply stimulated by exhaustion of the liver glycogen reserves, is one of the factors maintaining the normal blood sugar level in mice with tumors. Hyperglycemia induce by glucose leads to an increase in the liver glycogen content and a decrease in the intensity of gluconeogenesis in control mice with tumors. Only in the latter, however, does glycogen synthesis from noncarbohydrate compounds rise again steadily after the injections of glucose are discontinued.
D000818:Animals; D005943:Gluconeogenesis; D005947:Glucose / Q000378:metabolism; D006003:Glycogen / Q000096:biosynthesis; D006943:Hyperglycemia / Q000209:etiology*; D008099:Liver / Q000378:metabolism*; D008297:Male; D051379:Mice; D009368:Neoplasm Transplantation; D009374:Neoplasms, Experimental / Q000150:complications / Q000378:metabolism*; D014443:Tyrosine / Q000378:metabolism
D014443:Tyrosine; D006003:Glycogen; D005947:Glucose