In vitro determination of relative corticosteroid potency.
The corticosteroid concentration required to inhibit phytohemagglutinin stimulated human lymphocyte transformation by 50% was determined for three corticosteroids. The relative potency of hydrocortisone, prednisolone and dexamethasone determined in 16 patients was 1.00, 2.43, and 24.7 respectively. This assay is proposed as an objective tool for comparison of relative corticosteroid potency in man.
D000305:Adrenal Cortex Hormones / Q000032:analysis*; D003907:Dexamethasone / Q000032:analysis / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D005260:Female; D006801:Humans; D006854:Hydrocortisone / Q000032:analysis / Q000494:pharmacology; D037102:Lectins / Q000037:antagonists & inhibitors / Q000494:pharmacology; D008213:Lymphocyte Activation; D008297:Male; D008875:Middle Aged; D011239:Prednisolone / Q000032:analysis / Q000494:pharmacology; D013936:Thymidine / Q000378:metabolism
D000305:Adrenal Cortex Hormones; D037102:Lectins; D003907:Dexamethasone; D011239:Prednisolone; D013936:Thymidine; D006854:Hydrocortisone