Reversal of fungitoxicity of 8-quinolinols and their copper (II) bischelates. I. Amino acids and related compounds.
The effect of amino acids and related compounds on the toxicity of 8-quinolinols and their copper (II) bischelates to Aspergillus oryzae (ATCC 1011) Was studied. None of the compounds tested except the thiol-containing compounds, cysteine, cysteamine, glutathione, and N-acetylcysteine reversed the inhibitory action of 8-quinolinol but not that of 5-iodo-8-quinolinol or bis (8-quinolinolato) copper (II). It appears that the mechanism(s) of fungitoxicity of 8-quinolinol is different from that of 5-iodo-8-quinolinol or bis(8-quinolinolato) copper (II.).
D000111:Acetylcysteine / Q000494:pharmacology; D000596:Amino Acids / Q000494:pharmacology*; D000935:Antifungal Agents; D001230:Aspergillus / Q000187:drug effects* / Q000254:growth & development; D003300:Copper / Q000494:pharmacology*; D003543:Cysteamine / Q000494:pharmacology; D003545:Cysteine / Q000494:pharmacology; D004336:Drug Antagonism; D005978:Glutathione / Q000494:pharmacology; D009942:Organometallic Compounds / Q000494:pharmacology*; D011804:Quinolines / Q000494:pharmacology*
D000596:Amino Acids; D000935:Antifungal Agents; D009942:Organometallic Compounds; D011804:Quinolines; D003543:Cysteamine; D003300:Copper; D005978:Glutathione; D003545:Cysteine; D000111:Acetylcysteine