Inhalation carcinogenicity of alpha halo ethers. II. Chronic inhalation studies with chloromethyl methyl ether.
Rats and hamsters were exposed to 1 ppm of chloromethyl methyl ether six hours per day, five days per week, throughout their lifetime. Mortality and weight gain of the exposed animals paralleled that of the control animals. Malignant tumors of the respiratory tract were found in two rats. These were a squamous cell carcinoma of the lung with blood vessel invasion and an esthesloneuroepithelioma originating in the olfactory epithelium and invading the forebrain. One hamster was found to have an adenocarcinoma of the lung and another, a squamous papilloma of the trachea. A single exposed rat had a pituitary tumor of primitive cell type that may well have been coincidental.
D000230:Adenocarcinoma / Q000139:chemically induced; D000818:Animals; D001984:Bronchial Neoplasms / Q000139:chemically induced; D002273:Carcinogens; D002294:Carcinoma, Squamous Cell / Q000139:chemically induced; D006224:Cricetinae; D004781:Environmental Exposure; D008175:Lung Neoplasms / Q000139:chemically induced; D008297:Male; D008737:Methyl Chloride / Q000633:toxicity*; D008738:Methyl Ethers / Q000633:toxicity*; D018241:Neuroectodermal Tumors, Primitive, Peripheral / Q000139:chemically induced; D009669:Nose Neoplasms / Q000139:chemically induced; D010212:Papilloma / Q000139:chemically induced; D010911:Pituitary Neoplasms / Q000139:chemically induced; D051381:Rats; D012142:Respiratory Tract Neoplasms / Q000139:chemically induced*; D014134:Tracheal Neoplasms / Q000139:chemically induced
D002273:Carcinogens; D008738:Methyl Ethers; D008737:Methyl Chloride