Glomerular-tubular balance for bicarbonate in man.
We recently showed in dogs that there is a close relationship between bicarbonate reabsorption and glomerular filtration rate (GFR). The present studies were designed to confirm these findings in five normal men. Bicarbonate titrations were done after ingesting a low protein diet for one week and were repeated following elevation of GFR 11-29 per cent by high protein diet and dexamethazone ingestion. In every casetubular reabsorption of bicarbonate increased in proportion to the increases in GFR. We conclude that glomerular-tubular balance for bicarbonate reabsorption is a characteristic of human, as well as canine kidneys.
D000042:Absorption; D000328:Adult; D000818:Animals; D001639:Bicarbonates / Q000008:administration & dosage / Q000378:metabolism*; D003907:Dexamethasone; D004044:Dietary Proteins / Q000008:administration & dosage; D004231:Diuresis; D004285:Dogs; D005919:Glomerular Filtration Rate; D006801:Humans; D007263:Infusions, Parenteral; D007678:Kidney Glomerulus / Q000378:metabolism* / Q000502:physiology; D007684:Kidney Tubules / Q000378:metabolism* / Q000502:physiology; D008297:Male; D012964:Sodium / Q000008:administration & dosage / Q000378:metabolism
D001639:Bicarbonates; D004044:Dietary Proteins; D003907:Dexamethasone; D012964:Sodium