Multiple sclerosis immunogenetics. A possible correlation with human leukocyte HL-A antigens.
To investigate the relationships of genotype to susceptibility to multiple sclerosis, 42 patients hospitalized into Multiple Sclerosis Study Center of The Milan Medical School were typed for 14 HL-A specificities: HL-A1, HL-A2 + W 28, HL-A3, HL-A10 + W 19, HL-A11, HL-A9 of the 1st Series and HL-A5, HL-A7, HL-A8, HL-A12, HL-A13 of the 2nd Series. The increased HL-A9 frequency found in a previous study has been confirmed. Moreover in the total of multiple sclerosis patients this deviation reaches a higher degree of significance (P less than 0.01) and one antigen HL-A10 + W 19 appears to be significantly decreased (P less than 0.01). No variations were found in HL-A3, HL-A7 frequencies.
D002986:Clinical Trials as Topic; D005260:Female; D005787:Gene Frequency; D005838:Genotype; D006680:HLA Antigens; D006649:Histocompatibility Antigens; D006650:Histocompatibility Testing; D006801:Humans; D007962:Leukocytes / Q000276:immunology; D008297:Male; D009103:Multiple Sclerosis / Q000235:genetics / Q000276:immunology*
D006680:HLA Antigens; D006649:Histocompatibility Antigens