Metabolism in vitro of enflurane, isoflurane, and methoxyflurane.
Specific activities of enflurane, isoflurane, and methoxyflurane defluorinases were measured in microsomes prepared from the livers of Fischer 344 rats; the ratio of these activities was 23:3:1. Pretreatment with phenobarbital significantly increased the defluorinase activities of all three agents. Factors that influence anesthetic drug metabolism are discussed; tissue solubility is considered to be the most important.
D000769:Anesthesia, Inhalation; D000777:Anesthetics / Q000378:metabolism; D000818:Animals; D055598:Chemical Phenomena; D002621:Chemistry; D004790:Enzyme Induction / Q000187:drug effects; D004987:Ethers / Q000378:metabolism*; D006845:Hydrocarbons, Fluorinated / Q000378:metabolism; D006846:Hydrocarbons, Halogenated / Q000378:metabolism; D066298:In Vitro Techniques; D008733:Methoxyflurane / Q000378:metabolism*; D008738:Methyl Ethers / Q000378:metabolism*; D008862:Microsomes, Liver / Q000187:drug effects / Q000201:enzymology / Q000378:metabolism*; D010088:Oxidoreductases / Q000378:metabolism*; D010634:Phenobarbital / Q000494:pharmacology; D051381:Rats; D011916:Rats, Inbred F344
D000777:Anesthetics; D004987:Ethers; D006845:Hydrocarbons, Fluorinated; D006846:Hydrocarbons, Halogenated; D008738:Methyl Ethers; D008733:Methoxyflurane; D010088:Oxidoreductases; D010634:Phenobarbital