Increase in bilirubin-binding affinity of serum with age of infant.
The bilirubin-binding affinity of infant serum, as determined by Sephadex gel filtration, began to increase during the first week of life and continued to increase gradually until the age of 5 months, when it reached that of adult serum. This increase might be due to a transition from a fetal to an adult type of serum albumin and/or to a decrease in the concentration in serum of the substances thought to compete with bilirubin for binding to albumin.
D000367:Age Factors; D001663:Bilirubin / Q000097:blood*; D002850:Chromatography, Gel; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D011485:Protein Binding; D012709:Serum Albumin / Q000378:metabolism
D012709:Serum Albumin; D001663:Bilirubin