Distribution of intravenous sodium acetylsalicylate in the unanaesthetized rat on stimulation and inhibition of gastric secretion.
Sodium carboxyl-14C acetylsalicylate was injected intravenously into fasted rats in which gastric secretion was either inhibited by atropine or stimulated by histamine. After one hour blood samples and specimens from the glandular portion of the gastric mucosa, muscle, liver, and kidney were taken. The 14C activity in the blood and specimens was determined by liquid scintillation counting after combustion. The drug concentration was lowest in muscle and gastric mucosa, intermediate in the liver, and highest in the kidney, where it equalled that in the blood. The concentrations were proportional to the amount of drug injected in all the examined tissues. There was no difference between rats given histamine and those given atropine. The secretory state of the gastric mucosa thus did not affect the concentration of the drug in this tissue when acetylsalicylate was given intravenously.
D000818:Animals; D001241:Aspirin / Q000008:administration & dosage / Q000097:blood / Q000378:metabolism*; D001285:Atropine / Q000494:pharmacology; D005750:Gastric Juice / Q000378:metabolism*; D005753:Gastric Mucosa / Q000378:metabolism; D006632:Histamine / Q000494:pharmacology; D007275:Injections, Intravenous; D007668:Kidney / Q000378:metabolism; D008099:Liver / Q000378:metabolism; D008297:Male; D009132:Muscles / Q000378:metabolism; D051381:Rats; D012636:Secretory Rate / Q000187:drug effects; D013268:Stimulation, Chemical
D001285:Atropine; D006632:Histamine; D001241:Aspirin