Evidence of major role of the intestine in cholesterol synthesis in the adult male rat.
By an new in vivo method using 1-14-C-acetate, it becomes apparent that the intestine is the main organ concerned in cholesterol synthesis. The liver contributes a mere 13.5% to the total. These results challenge the traditional theory which considers the liver as responsible for producing most of cholesterol synthesized by the rat.
D000085:Acetates / Q000378:metabolism; D000105:Acetyl Coenzyme A / Q000378:metabolism; D000818:Animals; D002245:Carbon Dioxide / Q000378:metabolism; D002784:Cholesterol / Q000096:biosynthesis* / Q000097:blood; D007413:Intestinal Mucosa / Q000378:metabolism*; D008099:Liver / Q000378:metabolism; D008297:Male; D008722:Methods; D051381:Rats; D013261:Sterols / Q000096:biosynthesis; D013997:Time Factors
D000085:Acetates; D013261:Sterols; D002245:Carbon Dioxide; D000105:Acetyl Coenzyme A; D002784:Cholesterol