Preparation of deuterium-labeled cocaine and benzoylecgonine.
The preparation of deuterium-labeled cocaine and benzoylecgonine by a site-specific method is reported. This method involves the reductive dehalogenation of appropriately substituted derivatives by a NaBD4 - PdCl2 system. By the judicious choice of halogen-substituted aromatic systems, a wide variety of specifically deuterated compounds of biological interest can be prepared.
D055598:Chemical Phenomena; D002621:Chemistry; D003042:Cocaine / Q000031:analogs & derivatives* / Q000138:chemical synthesis; D003903:Deuterium; D007553:Isotope Labeling / Q000379:methods; D008968:Molecular Conformation
D003903:Deuterium; D003042:Cocaine