Familial, isolated, complete right bundle-branch block.
An electrocardiographic study of the families of two children with isolated complete right bundle-branch block is presented. Several cases of classical complete right bundle-branch block were disclosed (17/69 and 3/22 respectively) in three generations of the two families. Personal interviews and parish registers showed that the two families were related, being descendants 8 generations back from a glass-blower who has emigrated to Sweden in the eighteenth century. It is concluded that complete right bundle-branch block can be an autosomal, genetic anomaly which is inherited dominantly but with reduced penetrance and/or expressivity.
D000293:Adolescent; D000328:Adult; D002037:Bundle-Branch Block / Q000235:genetics* / Q000503:physiopathology; D006328:Cardiac Catheterization; D002648:Child; D004562:Electrocardiography; D005260:Female; D005799:Genes, Dominant; D006801:Humans; D008297:Male; D008875:Middle Aged; D010375:Pedigree