Quinoxaline studies. 23. Potential antimalarials. Substituted 5,8-dimethoxy-6-[N-(omega-dimethylaminoalkyl)amino]quinoxalines were prepared: the first series with identical 2,3-substituents H, CH3, C6H5, C6H4-4-Cl, and CH2C6H5; and the second with identical styryl groups CH=CHC6H5, CH=CHC6H4-4-Cl, CH=CHC6H3-3,4-Cl2, CH=CHC6H4-4-F, CH=CHC6H4-4-CF3, and CH=CHC6H4-4-NO2. None of the substances possessed antimalarial activity; several were toxic at highest dosage levels.
3-Hydrazinopyridazines substituted in position 6 with a primary amine, secondary amine, or an alkoxy group were synthesized and screened for antihypertensive activity.  In general, the 6-dialklamino derivatives are the most active; the (2-hydroxypropyl)methylamino chain provides the best combination of high antihypertensive activity and toxicity.
D000818:Animals; D000959:Antihypertensive Agents / Q000138:chemical synthesis* / Q000633:toxicity; D001794:Blood Pressure / Q000187:drug effects; D002415:Cats; D003864:Depression, Chemical; D006834:Hydrazines / Q000138:chemical synthesis / Q000494:pharmacology / Q000633:toxicity; D006977:Hypertension, Renal / Q000503:physiopathology; D007928:Lethal Dose 50; D011724:Pyridazines / Q000138:chemical synthesis* / Q000494:pharmacology / Q000633:toxicity; D051381:Rats
D000959:Antihypertensive Agents; D006834:Hydrazines; D011724:Pyridazines