Mass reconstitution of neutral cephalothin sodium using tandem sequence filling.
A procedure is described for reconstituting and packaging neutral cephalothin sodium in large numbers of underfilled minibags for i.v. bolus administration. A special rack to hold six 20-g Keflin vials was designed for the procedure which employs an automatic pipetting device in a laminar air flow hood. A reconstitution deck and needle holder are used in the admixing stage. The minibags are frozen and later thawed prior to dispensing. The average labor and material cost (excluding drug and minibag) ranges from $0.195 to $0.124 per minibag depending on batch size. The 20-g neutral cephalothin sodium vial improves speed of reconstitution and does not require transfer into an intermediate container during the packaging cycle.
D002512:Cephalothin; D003365:Costs and Cost Analysis; D004339:Drug Compounding / Q000295:instrumentation / Q000379:methods; D004340:Drug Contamination / Q000517:prevention & control
D002512:Cephalothin