Indomethacin potentiation of the response of the rabbit portal vein to electrical stimulation: effect of stimulus frequency and train length.
The response of the rabbit isolated portal vein to electrical stimulation was potentiated by indomethacin (10 mug/ml). This potentiation was dependent upon frequency but independent of the number of pulses in a train. It is concluded that these results add further support for the idea that indomethacin increases the release of newly synthesized noradrenaline as a result of inhibition of prostaglanding synthesis.
D000818:Animals; D004558:Electric Stimulation; D066298:In Vitro Techniques; D007213:Indomethacin / Q000494:pharmacology*; D008297:Male; D009119:Muscle Contraction / Q000187:drug effects; D009638:Norepinephrine / Q000096:biosynthesis; D011169:Portal Vein / Q000187:drug effects / Q000502:physiology*; D011453:Prostaglandins / Q000096:biosynthesis; D011817:Rabbits; D013997:Time Factors
D011453:Prostaglandins; D009638:Norepinephrine; D007213:Indomethacin