Effect of metiamide on the response to secretin and cholecystokinin in man.
The effects of intravenous metiamide on the pancreatic exocrine response to intravenous infusion of secretin plus cholecystokinin has been studied in eight patients with duodenal ulceration. The secretion of bicarbonate and water was not altered by metiamide. The secretion of enzymes was significantly less than control during infusion of metiamide. The differences between the pancreatic and gastric responses to metiamide are discussed.
D001639:Bicarbonates / Q000378:metabolism; D001654:Bile Pigments / Q000032:analysis; D002766:Cholecystokinin / Q000008:administration & dosage / Q000494:pharmacology*; D004381:Duodenal Ulcer / Q000188:drug therapy / Q000503:physiopathology*; D005215:Fasting; D005750:Gastric Juice / Q000378:metabolism; D006801:Humans; D007093:Imidazoles / Q000494:pharmacology / Q000627:therapeutic use; D007275:Injections, Intravenous; D010179:Pancreas / Q000187:drug effects* / Q000378:metabolism; D011092:Polyethylene Glycols; D012633:Secretin / Q000008:administration & dosage / Q000494:pharmacology*; D013270:Stomach / Q000187:drug effects; D013440:Sulfides / Q000494:pharmacology / Q000627:therapeutic use; D013890:Thiourea / Q000032:analysis* / Q000494:pharmacology / Q000627:therapeutic use; D014357:Trypsin / Q000378:metabolism
D001639:Bicarbonates; D001654:Bile Pigments; D007093:Imidazoles; D013440:Sulfides; D012633:Secretin; D011092:Polyethylene Glycols; D002766:Cholecystokinin; D014357:Trypsin; D013890:Thiourea