Synthesis of 2-(N-arylcarboxamide)-3-substituted ethoxyindoles and their monoamine oxidase inhibitory and anticonvulsant activities.
2-(N-Arylcarboxamide)-3-substituted ethoxyindoles were synthesized by the reaction of 2-(N-arylcarboxamide)-3-hydroxyindoles, which were obtained by the cyclization of 2-carbomethoxyphenylglycine-substituted anilides. These 2-(N-arylcarboxamide)-3-substituted ethoxyindoles were evaluated for their in vitro monoamine oxidase inhibitory ability and in vivo monamine oxidase inhibitory property as evidence by reserpine reversal response. Their anticonvulsant activity also was determined against pentylenetetrazol-induced seizures. No definite correlation could be observed between chemical structure and biological activity.
D000927:Anticonvulsants; D007211:Indoles / Q000138:chemical synthesis* / Q000494:pharmacology / Q000633:toxicity; D007928:Lethal Dose 50; D008996:Monoamine Oxidase Inhibitors; D013329:Structure-Activity Relationship
D000927:Anticonvulsants; D007211:Indoles; D008996:Monoamine Oxidase Inhibitors