Free amino acids in serum of patients with epilepsy: significant increase in taurine.
More than half the amino acids determined in serum were lower in patients with epilepsy than in control subjects. Taurine was the only amino acid to be increased in epilepsy. The changes could represent a compensatory metabolic reaction to limit the imbalance of amino acids in epileptic brain and to facilitate uptake of taurine, which has an anticonvulsant action.
D000293:Adolescent; D000328:Adult; D000596:Amino Acids / Q000097:blood* / Q000134:cerebrospinal fluid; D001812:Blood-Brain Barrier; D002852:Chromatography, Ion Exchange; D004827:Epilepsy / Q000097:blood* / Q000134:cerebrospinal fluid; D005260:Female; D006801:Humans; D008297:Male; D013654:Taurine / Q000097:blood* / Q000134:cerebrospinal fluid
D000596:Amino Acids; D013654:Taurine