An assessment of the effects of hormones on short term organ cultures of human breast carcinomata.
Twenty-eight mammary carcinomata were maintained in organ culture in the presence of various hormones. The effects of the hormones have been assessed histologically by estimation of total dehydrogenases activity of the pentose glycolytic pathway and by the incorporation of tritiated thymidine or uridine into DNA or RNA. No significant effects on tumour cell activity due to hormones have been observed.
D001940:Breast / Q000187:drug effects; D001943:Breast Neoplasms / Q000188:drug therapy* / Q000201:enzymology / Q000378:metabolism; D004273:DNA, Neoplasm / Q000096:biosynthesis; D004958:Estradiol / Q000627:therapeutic use; D005260:Female; D006728:Hormones / Q000627:therapeutic use*; D006801:Humans; D009924:Organ Culture Techniques; D010088:Oxidoreductases / Q000032:analysis; D011388:Prolactin / Q000627:therapeutic use; D012334:RNA, Neoplasm / Q000096:biosynthesis; D013629:Tamoxifen / Q000494:pharmacology; D013739:Testosterone / Q000627:therapeutic use; D013936:Thymidine / Q000378:metabolism; D014529:Uridine / Q000378:metabolism
D004273:DNA, Neoplasm; D006728:Hormones; D012334:RNA, Neoplasm; D013629:Tamoxifen; D013739:Testosterone; D004958:Estradiol; D011388:Prolactin; D010088:Oxidoreductases; D013936:Thymidine; D014529:Uridine