In vitro study on the effects of silver sulfadiazine on bilirubin binding.
Silver sulfadiazine is a new topical antimicrobial agent with a broad spectrum of activity against most bacterial (both gram-positive and gram-negative) and many fungal species. This broad spectrum of activity suggests that silver sulfiazine may be useful in clinical situations which require the inhibition of cutaneous bacterial and/or fungal colonization. The present study was undertaken to determine the effect of this agent on a bilirubin-protein binding. Using chromatographic procedures on artificially jaundiced sera and human serum albumin solutions, we were unable to detect any releast of protein-bound bilirubin by a saturated suspension of silver sulfadiazine.
D000328:Adult; D001663:Bilirubin / Q000097:blood*; D002110:Caffeine / Q000494:pharmacology; D002850:Chromatography, Gel; D006801:Humans; D007565:Jaundice / Q000097:blood; D011485:Protein Binding; D012709:Serum Albumin / Q000378:metabolism; D012834:Silver / Q000494:pharmacology; D013411:Sulfadiazine / Q000494:pharmacology*
D012709:Serum Albumin; D013411:Sulfadiazine; D002110:Caffeine; D012834:Silver; D001663:Bilirubin