Drug-induced inhibition of myeloid colony growth: protective effect of colony-stimulating factor.
The effect of some potentially myelotoxic drugs on the growth of colony-forming cells in mouse marrow in vitro was examined. Among the drugs tested chloramphenicol, thiamphenicol, and chlorpromazine were inhibitory in therapeutic concentrations, a finding consistent with the common occurrence of a dose-dependent leukopenia from these drugs. The degree of drug-induced inhibition of colony growth was inversely proportional to the concentration of colony-stimulating factor in the medium. It is postulated that the concentration of colony-stimulating factor in the cell milieu in vivo may play a significnat role in determining the occurrence or degree of leukopenia from thses drugs.
D000818:Animals; D001853:Bone Marrow / Q000187:drug effects / Q000276:immunology*; D001854:Bone Marrow Cells; D002455:Cell Division / Q000187:drug effects*; D002701:Chloramphenicol / Q000494:pharmacology; D002746:Chlorpromazine / Q000494:pharmacology; D002999:Clone Cells / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D066298:In Vitro Techniques; D007970:Leukopenia / Q000139:chemically induced*; D051379:Mice; D010653:Phenylbutazone / Q000494:pharmacology; D010672:Phenytoin / Q000494:pharmacology; D013752:Tetracycline / Q000494:pharmacology; D013839:Thiamphenicol / Q000494:pharmacology
D010672:Phenytoin; D002701:Chloramphenicol; D013752:Tetracycline; D013839:Thiamphenicol; D010653:Phenylbutazone; D002746:Chlorpromazine