Antiarrhythmic activity of 3-amino-3-methyloxindoles.
A series of 3-amino-3-methyloxindoles was synthesized from indoles by modification of previously described procedures. All compounds showed activity against chloroform-induced arrhythmias in mice. One member of the series, 3-methyl-3-piperidinooxindole, displayed activity equal to that of lidocaine while showing only one-third the acute toxicity.
D000588:Amines / Q000032:analysis / Q000627:therapeutic use / Q000633:toxicity; D000818:Animals; D000889:Anti-Arrhythmia Agents / Q000627:therapeutic use* / Q000633:toxicity; D001145:Arrhythmias, Cardiac / Q000139:chemically induced / Q000188:drug therapy*; D002725:Chloroform; D005260:Female; D007211:Indoles / Q000032:analysis / Q000627:therapeutic use* / Q000633:toxicity; D008012:Lidocaine / Q000627:therapeutic use*; D051379:Mice
D000588:Amines; D000889:Anti-Arrhythmia Agents; D007211:Indoles; D002725:Chloroform; D008012:Lidocaine