Distribution of 3H-uridine-5 into brain RNA species of rats exposed to various training tasks - an electrophoretic analysis.
Operant schedules were used to isolate component parts of a training task and specific activities were determine for nuclear and cytoplasmic RNA species separated by polyacrylamide disc gel electrophoresis. Rats exposed to a stimulus or schedule change incorporated more radioactivity into nuclear rRNA and mRNA and cytoplasmic rRNA and tRNA than littermates exposed to no change from baseline training. Rats developing a change in response probability to a stimulus in the environment incorporated more radioactivity into cytoplasmic mRNA.
D000818:Animals; D001921:Brain / Q000648:ultrastructure; D001923:Brain Chemistry; D002467:Cell Nucleus / Q000378:metabolism; D003593:Cytoplasm / Q000378:metabolism; D004591:Electrophoresis, Polyacrylamide Gel; D005108:Extinction, Psychological; D007858:Learning / Q000502:physiology*; D008297:Male; D012313:RNA / Q000378:metabolism*; D012333:RNA, Messenger / Q000378:metabolism; D012335:RNA, Ribosomal / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains; D012055:Reinforcement Schedule; D013056:Spectrophotometry, Ultraviolet; D014529:Uridine / Q000378:metabolism*
D012333:RNA, Messenger; D012335:RNA, Ribosomal; D012313:RNA; D014529:Uridine