Studies on an unstable phenotype induced by UV irradiation: the lysine excreting (lex(-)) phenotype of the yeast Saccharomycosis lipolytica.
Unstable clones excreting L-lysine into their growth medium are obtained at a very high frequency following UV irradiation in both haploid and diploid strains of Saccharomycopsis lipolytica, provided they carry a mutation affecting the first enzyme of the lysine pathway and confering resistance to end product inhibition.  The phenotype can be stabilized in some sublines; it appears as dominant and coupled with a decrease in spore viability.  Excretion in batch cultures is confined to the end of the exponential phase, and seems not to consist in a simple release of the lysine pool content.
D000596:Amino Acids / Q000096:biosynthesis; D001203:Ascomycota / Q000528:radiation effects*; D002470:Cell Survival / Q000528:radiation effects; D002999:Clone Cells; D003433:Crosses, Genetic; D003470:Culture Media; D004171:Diploidy; D005809:Genes, Regulator / Q000528:radiation effects; D014644:Genetic Variation; D007700:Kinetics; D008239:Lysine / Q000096:biosynthesis*; D009154:Mutation; D010641:Phenotype; D011831:Radiation Genetics; D012442:Saccharomycopsis / Q000378:metabolism / Q000528:radiation effects*; D013172:Spores, Fungal / Q000254:growth & development; D014466:Ultraviolet Rays
D000596:Amino Acids; D003470:Culture Media; D008239:Lysine