Preparation, quality control and clinical acceptance of labeled Macrotec.
Thirty minutes after reconstitution, radiochemical purity determinations of the lung-scanning agent Macrotec (99m-Tc-MAA) indicated 95-100% technetium labeling: 76% of the particles had a mean diameter of 10-50 mu. Rat tissue distribution studies indicated lung uptake of 98% at 15 minutes. The biological half-life in the lung was 8.3 hours. In 12 patients requiring emergency lung scans, 9 scans were rated excellent. No liver, spleen or thyroid uptake or adverse reactions were noted.
D000818:Animals; D006801:Humans; D008168:Lung / Q000378:metabolism; D008171:Lung Diseases / Q000175:diagnosis; D011655:Pulmonary Embolism / Q000175:diagnosis; D011877:Radionuclide Imaging / Q000592:standards; D051381:Rats; D012588:Scintillation Counting; D012709:Serum Albumin / Q000378:metabolism / Q000592:standards; D013667:Technetium
D012709:Serum Albumin; D013667:Technetium