Phosphonoacetic acid in the treatment of experimental herpes simplex keratitis.
In a rabbit model of herpes simplex corneal ulceration, 5% phosphonoacetic acid solution or ophthalmic ointment suppressed clinical disease and virus replication. The effect of 5% phosphonoacetic acid ointment was equivalent to that of 0.5% idoxuridine ointment in the treatment of this established herpetic eye infection.
D000085:Acetates / Q000009:adverse effects / Q000627:therapeutic use*; D000818:Animals; D005260:Female; D007635:Keratitis, Dendritic / Q000188:drug therapy*; D009943:Organophosphorus Compounds / Q000009:adverse effects / Q000627:therapeutic use*; D011817:Rabbits
D000085:Acetates; D009943:Organophosphorus Compounds