Preservation of estrogen-induced increase of uterine blood volume following catechlamine and mast cell histamine depletion.
Uterine blood volume increases after administration of estrogen to ovariectomized mice. The effect on uterine blood volume was not altered by depletion of mast cell histamine with compound 48/80 or by depletion of norepinephrine from uterine nerves by 6-hydroxydopamine. Thus, neither reduction in the adrenergic transmitter content nor release of mast cell histamine appears to play any primary role in mediating the changes in uterine hemodynamics produced by estrogen, at least as they are reflected by changes in uterine blood volume.
D000818:Animals; D001810:Blood Volume / Q000187:drug effects*; D001811:Blood Volume Determination; D002369:Castration; D004285:Dogs; D004958:Estradiol / Q000008:administration & dosage / Q000494:pharmacology; D004967:Estrogens / Q000494:pharmacology*; D005260:Female; D005615:Freezing; D006632:Histamine / Q000378:metabolism*; D006892:Hydroxydopamines / Q000008:administration & dosage / Q000494:pharmacology; D008407:Mast Cells / Q000378:metabolism*; D051379:Mice; D009638:Norepinephrine / Q000378:metabolism*; D012711:Serum Albumin, Radio-Iodinated; D014599:Uterus / Q000098:blood supply* / Q000294:innervation; D003189:p-Methoxy-N-methylphenethylamine / Q000008:administration & dosage / Q000494:pharmacology
D004967:Estrogens; D006892:Hydroxydopamines; D012711:Serum Albumin, Radio-Iodinated; D003189:p-Methoxy-N-methylphenethylamine; D004958:Estradiol; D006632:Histamine; D009638:Norepinephrine