Tumour angiogenic factor associated with subcutaneous lymphoma.
Growth and survival of cutaneous neoplasms are dependent on the development of a nutrient-supplying vascular lifeline. A subcutaneous lymphoma is described which mimicked a vascular neoplasm because of the extensive telangiectasia overlying the tumour. Fragments of the lymphoma inserted in direct apposition to the hamster cheek pouch membrane or separated from the membrane by a microporous filter both induced dramatic neovascularization. Control materials failed to induce significant vascular changes. A diffusable Tumour Angiogenic Factor may play a vital role in tumour survival and portends a therapeutic potential.
D043925:Angiogenesis Inducing Agents / Q000032:analysis*; D000818:Animals; D001706:Biopsy; D002675:Child, Preschool; D006224:Cricetinae; D005260:Female; D006133:Growth Substances / Q000032:analysis*; D006801:Humans; D008223:Lymphoma / Q000032:analysis / Q000150:complications / Q000503:physiopathology*; D012867:Skin / Q000098:blood supply*; D012878:Skin Neoplasms / Q000032:analysis / Q000150:complications / Q000503:physiopathology*; D013684:Telangiectasis / Q000209:etiology
D043925:Angiogenesis Inducing Agents; D006133:Growth Substances