Thrombocytopenia in extracorporeal circulation (ECC). II: Bubble oxygenator versus artificial kidney.
In summary, in contrast to a blood-membrane interphase system (artificial kidney), the use of a blood-gas interphase system (bubble oxygenator), even at a low flow rate of 400 ml/min, leads to severe changes in platelet function and number, to a temporary delay in fibrin formation and to a prolonged bleeding time. A definite bleeding tendency expresses the disturbance in hemostatic balance, as predominantly effected by the changes in platelet function. Hemolysis is apparently a minor symptom, and does not express the gravity of this damaging situation.
D000244:Adenosine Diphosphate / Q000494:pharmacology; D000818:Animals; D001772:Blood Cell Count; D001777:Blood Coagulation; D001792:Blood Platelets / Q000187:drug effects / Q000502:physiology; D004285:Dogs; D005112:Extracorporeal Circulation; D005337:Fibrin / Q000378:metabolism; D006454:Hemoglobins / Q000032:analysis; D006461:Hemolysis; D007688:Kidneys, Artificial; D010106:Oxygenators; D010974:Platelet Aggregation / Q000187:drug effects; D011517:Prothrombin Time; D013921:Thrombocytopenia / Q000209:etiology*; D013997:Time Factors
D006454:Hemoglobins; D000244:Adenosine Diphosphate; D005337:Fibrin