Some aspects of the radiopharmaceutics of 99m-Tc-phytate.
This paper outlines the method of preparation of 99m-Tc-phytate and its use for scanning the reticuloendothelial system. The tissue distribution studies in mice and rats indicate that 99m-Tc-phytate is a safe and effective liver imaging agent. This was confirmed by preliminary studies in human subjects. The stability of the aqueous tin-phytate complex is remarkably good, and it could be successfully used for more than two months to prepare the labelled product.
D000818:Animals; D055598:Chemical Phenomena; D002621:Chemistry; D003102:Colloids; D006801:Humans; D007294:Inositol / Q000031:analogs & derivatives*; D007553:Isotope Labeling / Q000379:methods; D008099:Liver / Q000378:metabolism; D051379:Mice; D012157:Mononuclear Phagocyte System; D010833:Phytic Acid / Q000378:metabolism*; D011877:Radionuclide Imaging; D051381:Rats; D013154:Spleen / Q000378:metabolism; D013667:Technetium / Q000378:metabolism*; D013997:Time Factors; D014001:Tin
D003102:Colloids; D007294:Inositol; D013667:Technetium; D014001:Tin; D010833:Phytic Acid