Effect of ethanol on toxicity and metabolism of amphetamine in the mouse.
Ethanol, 3 g/kg i.p., did not significantly alter the acute toxicity of amphetamine in the mouse. However, the urinary metabolite pattern was changed, suggesting that ethanol suppressed metabolism of the stimulant during the initial 6 h period. After 24 h, the mouse metabolized the same fraction of a given dose of amphetamine, whether it was given as amphetamine alone or amphetamine mixed with 2,3 or 4 g/kg ethanol.
D000818:Animals; D003913:Dextroamphetamine / Q000378:metabolism / Q000633:toxicity* / Q000652:urine; D004305:Dose-Response Relationship, Drug; D000431:Ethanol / Q000494:pharmacology*; D008297:Male; D051379:Mice; D013997:Time Factors
D000431:Ethanol; D003913:Dextroamphetamine