A comparative study of the relative efficacy of pyrantel pamoate, bephenium hydroxynaphthoate and tetrachlorethylene in the treatment of Necator americanus infection in Ceylon.
The clearance of hookworm (Necator americanus) ova by a single dose of tetrachlorethylene (T.C.E.) was compared with that produced by single and multiple dose regimes of bephenium hydroxynaphthoate and pyrantel pamoate. Single doses of bephenium and pyrantel were inferior to T.C.E. Three daily doses of bephenium or pyrantel produced effects comparable with a single dose of T.C.E. Because of the low cost and lack of side effects, T.C.E. remains the drug of choice in the treatment of N. americanus in infections; the only disadvantage of T.C.E. is its unnoticed deterioration under tropical conditions.
D000284:Administration, Oral; D000328:Adult; D001598:Bephenium Compounds / Q000008:administration & dosage / Q000627:therapeutic use*; D001835:Body Weight; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D004341:Drug Evaluation; D005243:Feces / Q000469:parasitology; D006454:Hemoglobins / Q000032:analysis; D006725:Hookworm Infections / Q000188:drug therapy*; D006801:Humans; D009331:Necator / Q000187:drug effects* / Q000302:isolation & purification; D009332:Necatoriasis / Q000097:blood / Q000188:drug therapy*; D011715:Pyrantel / Q000031:analogs & derivatives*; D011716:Pyrantel Pamoate / Q000008:administration & dosage / Q000627:therapeutic use*; D013188:Sri Lanka; D013750:Tetrachloroethylene / Q000008:administration & dosage / Q000627:therapeutic use*
D001598:Bephenium Compounds; D006454:Hemoglobins; D011715:Pyrantel; D011716:Pyrantel Pamoate; D013750:Tetrachloroethylene