Muscarinic receptors in rat intestinal muscle: comparison with the guinea pig.
The properties of muscarinic receptors in rat intestinal muscle have been investigated by examining the binding of 3H-propylbenzilylcholine mustard, 3H-PrBCM, a specific and virtually irreversible muscarinic antagonist. It is shown that the properties of these muscarinic receptore correspond in general closely to those observed in the guinea pig, in particular the binding curve inferred for carbachol shows the same apparent negative cooperativity, but there is a notable difference in the rate of binding 3H-PrBCM.
D000818:Animals; D001285:Atropine / Q000494:pharmacology; D001388:Aziridines / Q000378:metabolism; D001561:Benzilates / Q000378:metabolism; D002217:Carbachol / Q000494:pharmacology; D002794:Choline / Q000031:analogs & derivatives* / Q000378:metabolism; D006168:Guinea Pigs; D066298:In Vitro Techniques; D007413:Intestinal Mucosa / Q000378:metabolism*; D008297:Male; D009119:Muscle Contraction / Q000187:drug effects; D009130:Muscle, Smooth / Q000187:drug effects / Q000378:metabolism*; D009150:Mustard Compounds / Q000378:metabolism*; D051381:Rats; D011950:Receptors, Cholinergic; D013045:Species Specificity
D001388:Aziridines; D001561:Benzilates; D009150:Mustard Compounds; D011950:Receptors, Cholinergic; D001285:Atropine; D002217:Carbachol; D002794:Choline