A comparison of a new analgesic, floctafenine, with dextropropoxyphene and aspirin in post-operative pain..
Seventy-seven patients took part in a double-blind crossover trial to compare the effects of floctafenine, dextropropxyhene and aspirin in the relief of post-operative pain. Pain levels were recorded at hourly intervals and pain relief scores calculated. For Dose 1, the difference between the mean pain relief score for patients receiving floctafenin (12.8) and that for patients receiving dextropropoxyphen (6.2) was significant, (p smaller than 0.05) but the difference between the mean score for aspirin (9.2) and that for dextropropoxyphene was not significant. For Dose 2, there were no significant differences between the mean pain relief scores for floctafenine (12.5), for aspirin (10.9) and for dextropropoxyphene (13.2).
D000328:Adult; D000368:Aged; D000700:Analgesics / Q000627:therapeutic use*; D001241:Aspirin / Q000009:adverse effects / Q000627:therapeutic use*; D011431:Dextropropoxyphene / Q000009:adverse effects / Q000627:therapeutic use*; D006801:Humans; D008875:Middle Aged; D010149:Postoperative Pain / Q000188:drug therapy*; D011804:Quinolines / Q000009:adverse effects / Q000627:therapeutic use*; D062367:ortho-Aminobenzoates / Q000009:adverse effects / Q000627:therapeutic use*
D000700:Analgesics; D011804:Quinolines; D062367:ortho-Aminobenzoates; D001241:Aspirin; D011431:Dextropropoxyphene