Dose dependent kinetics of carbamazepine in the monkey.
The blood concentration-time curve of carbamazepine in monkeys following intravenous infusion of the drug at two different levels was determined using a specific gas liquid chromatographic assaymconcentration values measured over a two and one-half decade concentration range during zero order infusion as well as the decay portion of the curve for both doses were computer fit using a nonlinear least-squares program and found to follow Michaelis-Menten kinetics. There was little change found in the volume of distribution for carbamazepine from monkey to monkey, however, marked differences were noted in the metabolic rate constants.
D000818:Animals; D002220:Carbamazepine / Q000097:blood / Q000378:metabolism* / Q000652:urine; D002849:Chromatography, Gas; D004305:Dose-Response Relationship, Drug; D007700:Kinetics; D008253:Macaca mulatta; D008297:Male; D008954:Models, Biological
D002220:Carbamazepine