3H leucine incorporation into myofibrils of normal and dystrophic mouse skeletal muscle.
The study of 3H leucine incorporation into skeletal muscle of mouse muscular dystrophy (129 ReJ/dy Bar Harbour strain) shows the uptake of isotope into myofibrils. The techniques employed were light and EM autoradiography before and after glycerination (Szent-Gyorgyi 1947). The results indicate a marked drop in uptake of the 3H-Leucine into myofibrils in the dystrophic animals, supporting the contention of Nihei et al (1971) that reduced myosin synthesis occurs in mouse muscular dystrophy.
D000818:Animals; D004195:Disease Models, Animal; D005990:Glycerol / Q000494:pharmacology; D007930:Leucine / Q000378:metabolism*; D051379:Mice; D008815:Mice, Inbred Strains; D009132:Muscles / Q000187:drug effects / Q000378:metabolism; D009137:Muscular Dystrophy, Animal / Q000378:metabolism*; D009210:Myofibrils / Q000378:metabolism*; D012519:Sarcoplasmic Reticulum / Q000378:metabolism
D007930:Leucine; D005990:Glycerol