Influence of age and sex on the calcification of rat aorta in relation to bone mineralization.
Thoracic aortas of pvg rats accumulated Ca (analysed by flame spectrophotometry) throughout mature life, with females having slightly higher levels than males at each age interval studied. Femur Ca concentration was similarly elevated in female rats, and was maintained fairly constant in both sexes after 19 weeks of age. Femur Mg and K levels showed an over-all decrease with age; whilst the Na concentration fell up to 19 weeks, and then decreased steadily. It was concluded that a simple shift of Ca from the ageing skeleton into soft tissues cannot adequately account for aortic physiosclerosis.
D000367:Age Factors; D000368:Aged; D000375:Aging; D000818:Animals; D001011:Aorta / Q000032:analysis / Q000033:anatomy & histology / Q000378:metabolism*; D001835:Body Weight; D002113:Calcification, Physiologic; D002118:Calcium / Q000032:analysis / Q000378:metabolism*; D004285:Dogs; D005269:Femur / Q000032:analysis / Q000033:anatomy & histology / Q000378:metabolism*; D006801:Humans; D008274:Magnesium / Q000032:analysis; D008297:Male; D008875:Middle Aged; D009929:Organ Size; D011188:Potassium / Q000032:analysis; D051381:Rats; D012737:Sex Factors; D012964:Sodium / Q000032:analysis
D012964:Sodium; D008274:Magnesium; D011188:Potassium; D002118:Calcium