[Effects of verapamil on the electrical and mechanical activity of smooth muscle].
Verapamil inhibited both the electrical and the mechanical activity of isolated guinea-pig taenia coli. The action of the drug was similar in some respects to that of quinidine as far as the electrical activity was concerned. Closer similarities were observed between it and diphenylhydantoin. The conclusion is drawn that the drug has points of attack at the electromechanical junction and the membrane.
D000200:Action Potentials / Q000187:drug effects; D000818:Animals; D003106:Colon / Q000187:drug effects; D005071:Evoked Potentials / Q000187:drug effects; D006168:Guinea Pigs; D066298:In Vitro Techniques; D009119:Muscle Contraction / Q000187:drug effects; D009130:Muscle, Smooth / Q000187:drug effects*; D014700:Verapamil / Q000494:pharmacology*
D014700:Verapamil
Effetti del verapamil sull'attività elettrica e meccanica del muscolo liscio