Clearances of complement components, C3 proactivator and other serum proteins in chronic membranoproliferative glomerulonephritis (CMPGN).
In chronic membranoproliferative glomerulonephritis (CMPGN) the activation of the complement system through the properdin pathway plays an important role. The clearance of complement components and of the C3-proactivator (C3-PA) have been determined in 18 patients. Hemolytically active C5, C6, C7 and C3-PA were detected in the urine for the first time. The clearances of the complement components  did not correlate with the clearances of other serum proteins with similar molecular weights. The specificities of the single complement components in the urine were tested by specific complement inhibitors such as hydrazine, KSCN, and the C4-inactivating factor.
D000293:Adolescent; D000328:Adult; D001798:Blood Proteins / Q000378:metabolism*; D002648:Child; D003172:Complement C1 / Q000378:metabolism; D003175:Complement C2 / Q000378:metabolism; D003176:Complement C3 / Q000378:metabolism; D003181:Complement C4 / Q000378:metabolism; D003182:Complement C5 / Q000378:metabolism; D003183:Complement C6 / Q000378:metabolism; D003184:Complement C7 / Q000378:metabolism; D003165:Complement System Proteins / Q000378:metabolism*; D005260:Female; D005921:Glomerulonephritis / Q000097:blood / Q000276:immunology* / Q000652:urine; D006801:Humans; D007122:Immunoelectrophoresis; D008297:Male; D008875:Middle Aged; D008970:Molecular Weight; D009404:Nephrotic Syndrome / Q000276:immunology / Q000652:urine; D011414:Properdin / Q000378:metabolism; D011507:Proteinuria / Q000276:immunology
D001798:Blood Proteins; D003172:Complement C1; D003175:Complement C2; D003176:Complement C3; D003181:Complement C4; D003182:Complement C5; D003183:Complement C6; D003184:Complement C7; D011414:Properdin; D003165:Complement System Proteins