Action of prostaglandin F2alpha on pregnancy in hamsters: luteolytic and extra-ovarian effects.
Pregnancies in hamsters may be terminated by 10 mug PGF2alpha administered b.i.d. on days 4, k and 6 of gestation. Small (250 mug and above) daily injections of progesterone on the same days will reverse this PG effect; in contradistinction, 10 mg of progesterone per day failed to maintain normal pregnancies in hamsters spayed on day 5. Daily administration of 3 mg of progesterone and 1 mug of estrone essentially normalized the gestation; administration of PGF2alpha at 10 mg on days 5, 6 and 7 of pregnancy in steroid-maintained rats, resulted in pregnancy termination in all animals, while 1 mg was partly effective. These data demonstrate an extra-ovarian site of action of prostaglandin F2alpha on pregnancy in hamsters.
D000818:Animals; D002369:Castration; D006224:Cricetinae; D003864:Depression, Chemical; D004970:Estrone / Q000494:pharmacology; D005260:Female; D005865:Gestational Age; D010053:Ovary / Q000187:drug effects / Q000378:metabolism / Q000502:physiology; D011247:Pregnancy; D011270:Pregnancy, Animal / Q000187:drug effects*; D011374:Progesterone / Q000378:metabolism / Q000494:pharmacology; D011448:Prostaglandin Antagonists; D011460:Prostaglandins F / Q000494:pharmacology*
D011448:Prostaglandin Antagonists; D011460:Prostaglandins F; D004970:Estrone; D011374:Progesterone