Glutamine aminotransferase and glutamine aminohydrolase ratio as a possible test for antitumour compounds.
Three known antitumour drugs have been tested for their effect on the GAT/GNase ratio of Ehrlich Ascites cells and host plasma. It was observed that all these drugs had changed the ratio of the 2 types of glutaminases from below 1.0 to the normal value of 1.0, this was accompanied with an increase in the survival time of the tumour-bearing animals. There was, however, no effect on the plasma GAT/GNase ratio of normal animals in the presence of the 3 antitumour compounds tested.
D000619:Aminohydrolases / Q000097:blood*; D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology* / Q000627:therapeutic use; D002286:Carcinoma, Ehrlich Tumor / Q000188:drug therapy / Q000201:enzymology*; D003520:Cyclophosphamide / Q000494:pharmacology; D003609:Dactinomycin / Q000494:pharmacology; D005973:Glutamine; D051379:Mice; D008937:Mitomycins / Q000494:pharmacology; D000637:Transaminases / Q000097:blood*
D000970:Antineoplastic Agents; D008937:Mitomycins; D005973:Glutamine; D003609:Dactinomycin; D003520:Cyclophosphamide; D000637:Transaminases; D000619:Aminohydrolases