A controlled comparison of doxepin h.s. and doxepin q.i.d.
A controlled double-blind study of 40 depressed psychiatric outpatients who received doxepin either q.i.d. or h.s. showed that doxepin may be administered h.s. without loss of efficacy or increase in side effects. The patients who received doxepin h.s. felt significantly better rested in the morning than the patients who received doxepin in divided doses.
D000328:Adult; D001007:Anxiety / Q000187:drug effects; D003863:Depression / Q000188:drug therapy; D004316:Doxepin / Q000008:administration & dosage* / Q000009:adverse effects / Q000627:therapeutic use; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010919:Placebos; D011569:Psychiatric Status Rating Scales; D012893:Sleep Wake Disorders / Q000188:drug therapy; D013997:Time Factors
D010919:Placebos; D004316:Doxepin