Induction of hepatocellular mitosis with carbon tetrachloride in late-phase Ehrlich ascites tumour-bearing mice.
Hepatocellular mitoses are scanty or absent in livers of animals in the late stages of growth of Ehrlich ascites tumours. The challenge of CCl4-induced liver necrosis in such animals is, however, met by a massive hepatocellular mitotic response. Thus general debility of the animal, imposing a block on liver cell division cannot be an explantation for the cessation of tumour-associated liver cell mitosis in late-stage tumour-bearing animals. Possible explantations for the pattern of hepatocellular mitosis in relation to duration of tumour growth are discussed.
D000818:Animals; D002251:Carbon Tetrachloride / Q000494:pharmacology*; D002286:Carcinoma, Ehrlich Tumor / Q000473:pathology*; D008099:Liver / Q000187:drug effects / Q000473:pathology*; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D008938:Mitosis / Q000187:drug effects*; D009821:Oils; D013997:Time Factors
D009821:Oils; D002251:Carbon Tetrachloride