Influence of age on the formation of 5alpha-androstanediol and 7alpha-hydroxy-testosterone by incubated rat testes.
Testes from rats of different ages were indubated with or without tritiated testosterone. The exogenously-added or endogenously-produced testosterone is mainly metabolized to 7alpha-hydroxylated testosterone in adult animals, and to 5alpha-reduced metabolites (especially 5alpha-androstanediol) in immature animals.
D000375:Aging; D015113:Androstane-3,17-diol / Q000096:biosynthesis*; D000731:Androstanes / Q000096:biosynthesis*; D000818:Animals; D002850:Chromatography, Gel; D002854:Chromatography, Paper; D005470:Fluorometry; D006900:Hydroxylation; D006914:Hydroxysteroids / Q000096:biosynthesis; D008297:Male; D010084:Oxidation-Reduction; D051381:Rats; D013737:Testis / Q000378:metabolism*; D013739:Testosterone / Q000096:biosynthesis* / Q000378:metabolism; D014316:Tritium
D000731:Androstanes; D006914:Hydroxysteroids; D014316:Tritium; D015113:Androstane-3,17-diol; D013739:Testosterone