Natriuresis and carbohydrate-induced antinatriuresis in fasted, hydrated hypertensives.
After an overnight fast and oral hydration with water, hypertensive subjects developed a significant natriuresis (mean urine sodium excretions increased from 130 to 291 mueq/min. The incidence of a natriuresis (greater than 200 mueq sodium excreted per minute) was 75% in the hypertensive group (16 subjects) compared to 27% in a previously studied normotensive group (22 subjects). The incidence of a carbohydrate-induced antinatriuresis (greater than 30% decrease in urinary sodium excretion) was 62% in the hypertensive group compared to 41% in the normotensive group. No decrease in plasma volume (131I-labeled albumin concentration) due to a shift of solute and water intracellularly could be documented to explain the antinatriuretic effect of glucose. An incidental observation was a significant decrease in plasma zinc concentrations after glucose ingestion.
D000328:Adult; D000618:Aminohippuric Acids / Q000008:administration & dosage; D002118:Calcium / Q000652:urine; D005215:Fasting; D005947:Glucose / Q000494:pharmacology*; D006801:Humans; D006973:Hypertension / Q000378:metabolism / Q000503:physiopathology*; D007444:Inulin / Q000008:administration & dosage / Q000652:urine; D008274:Magnesium / Q000652:urine; D008875:Middle Aged; D009318:Natriuresis / Q000187:drug effects; D010953:Plasma Volume; D011188:Potassium / Q000097:blood / Q000652:urine; D012711:Serum Albumin, Radio-Iodinated; D012964:Sodium / Q000097:blood* / Q000652:urine; D014867:Water; D015032:Zinc / Q000097:blood / Q000652:urine
D000618:Aminohippuric Acids; D012711:Serum Albumin, Radio-Iodinated; D014867:Water; D007444:Inulin; D012964:Sodium; D008274:Magnesium; D005947:Glucose; D015032:Zinc; D011188:Potassium; D002118:Calcium