The synthesis of prostaglandin analogs containing hydroxycyclohexenyl rings.
The synthesis of prostaglandin analogs incorporating the 3-hydroxycyclohexenyl moiety in place of the natural C13-C20 side-chain has been accomplished via copper-assisted conjugate addition of the cycloalkenyllithium 2 to the cyclopentenous intermediates 4, 7 and 10.
D000818:Animals; D003511:Cyclohexanols / Q000138:chemical synthesis; D003517:Cyclopentanes; D006168:Guinea Pigs; D007082:Ileum / Q000187:drug effects; D066298:In Vitro Techniques; D009119:Muscle Contraction / Q000187:drug effects; D011453:Prostaglandins / Q000138:chemical synthesis* / Q000494:pharmacology
D003511:Cyclohexanols; D003517:Cyclopentanes; D011453:Prostaglandins