Effects of hormonal pretreatment of cardiac necrosis in the Japanese quail.
Male Japanese quail castrated and treated with beta-estradiol-3-benzoate for 3 wk were more resistant than sham-operated males to the necrogenic effects of massive doses of isoproterenol. The estrogen-treated castrate also weighed significantly more and had significantly lower hematocrit ratios than either the sham-operated male or the intact male. These results indicate that there is a definite sex-related protective effect this type of cardiac necrosis which cannot be explained on the basis of differences in body weight.
D000818:Animals; D002369:Castration; D003370:Coturnix; D004958:Estradiol / Q000494:pharmacology / Q000502:physiology*; D005260:Female; D006400:Hematocrit; D007545:Isoproterenol; D008297:Male; D009203:Myocardial Infarction / Q000139:chemically induced / Q000503:physiopathology*; D009206:Myocardium / Q000473:pathology; D009336:Necrosis; D012737:Sex Factors; D013739:Testosterone / Q000494:pharmacology / Q000502:physiology*
D013739:Testosterone; D004958:Estradiol; D007545:Isoproterenol