Effects of female sex hormones on uterine motility and reactivity to oxytocin in goats.
Uterine motility was recorded for several weeks in 10 ovariectomised goats, using small intra-uterine balloons, to study the effects of female sex hormones on uterine activity and reactivity to oxytocin. Oestradiol stimulated uterine contractions and increased both the sensitivity and intra-uterine pressure response to oxytocin. When progesterone was administered in addition to oestradiol, spontaneous uterine motility became irregular with low amplitude contrations; the sensitivity and reactivity to oxytocin was significantly depressed.
D000769:Anesthesia, Inhalation / Q000662:veterinary; D000818:Animals; D002369:Castration / Q000662:veterinary; D004958:Estradiol / Q000008:administration & dosage / Q000494:pharmacology*; D005260:Female; D006041:Goats / Q000502:physiology*; D006221:Halothane; D007273:Injections, Intramuscular; D007275:Injections, Intravenous; D010121:Oxytocin / Q000008:administration & dosage / Q000494:pharmacology*; D011312:Pressure; D011374:Progesterone / Q000008:administration & dosage / Q000494:pharmacology*; D014590:Uterine Contraction / Q000187:drug effects*
D011374:Progesterone; D004958:Estradiol; D010121:Oxytocin; D006221:Halothane