Studies on a gross-virus-induced lymphoma in the rat. II. The role of cell-membrane-associated and serum P30 antigen in the antibody and cell-mediated response.
The internal viral protein, p30-1, has been identified by cytotoxicity tests using xenogeneic sera, on MuLV-G-induced rat lymphoma cells. In this system internal virion antigens, and in particular p30, are  cytotoxic target antigens for syngeneic antibody and cell-mediated cytotoxicity; p30 is also present in the serum of rats with progressively growing lymphomas, and is the principal antigen responsible for the inhibition of cell-mediated cytotoxicity produced by these sera.
D000406:AKR murine leukemia virus / Q000276:immunology*; D000818:Animals; D000914:Antibodies, Viral; D000937:Antigen-Antibody Reactions; D000956:Antigens, Viral; D002460:Cell Line; D002462:Cell Membrane / Q000276:immunology; D003601:Cytotoxicity Tests, Immunologic; D007106:Immune Sera; D007111:Immunity, Cellular; D008223:Lymphoma / Q000276:immunology*; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D009374:Neoplasms, Experimental / Q000276:immunology*; D014764:Viral Proteins
D000914:Antibodies, Viral; D000956:Antigens, Viral; D007106:Immune Sera; D014764:Viral Proteins