Catecholamines concentration in brain and heart tissue of rats and its blood pressure during chronic treatment with a new tricyclic antidepressant 10-(3-dimethylaminopropyl)-7-chlorobenzo-(b), (1,8)-naphthyridone-5 monohydrochloride (IF-C-45).
DA concentration in brain tissue decreased statisticaly after 3, 6 and 9 weeks, NA concentration also statisticaly decreased but after 3 weeks only. The NA concentration in heart tissue decreased statisticaly significant in all investigated animals. There were no statisticaly significant changes in blood pressure.
D000311:Adrenal Glands / Q000032:analysis; D000818:Animals; D000929:Antidepressive Agents, Tricyclic / Q000494:pharmacology*; D001794:Blood Pressure / Q000187:drug effects*; D001835:Body Weight / Q000187:drug effects; D001923:Brain Chemistry / Q000187:drug effects*; D002395:Catecholamines / Q000032:analysis*; D004123:Dimethylamines / Q000494:pharmacology; D004298:Dopamine / Q000032:analysis; D004837:Epinephrine / Q000032:analysis; D008297:Male; D009206:Myocardium / Q000032:analysis*; D009287:Naphthyridines / Q000494:pharmacology*; D009638:Norepinephrine / Q000032:analysis; D009929:Organ Size / Q000187:drug effects; D051381:Rats; D013997:Time Factors
D000929:Antidepressive Agents, Tricyclic; D002395:Catecholamines; D004123:Dimethylamines; D009287:Naphthyridines; D004298:Dopamine; D009638:Norepinephrine; D004837:Epinephrine