Metabolism of papaverine. I. Identification of metabolites in rat bile.
1. After hydrolysis with glusulase of bile from rats treated with papaverine, four metabolites (A, B, C and D) were separated. 2. The structures A, B and C were established as monodemethylated compounds, 4'-desmethyl-, 7-desmethyl-, and 6-desmethylpapaverine, respectively. 3. D was formed from papaverine by bis-desmethylation. Since it was found in cat bile after administering either A or C, but not B, it was identified as 4', 6-desmethylpapaverine.
D000818:Animals; D001646:Bile / Q000378:metabolism*; D001711:Biotransformation; D002415:Cats; D055598:Chemical Phenomena; D002621:Chemistry; D002849:Chromatography, Gas; D002855:Chromatography, Thin Layer; D006868:Hydrolysis; D007274:Injections, Intraperitoneal; D007275:Injections, Intravenous; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D013058:Mass Spectrometry; D010208:Papaverine / Q000031:analogs & derivatives / Q000378:metabolism*; D051381:Rats; D014316:Tritium
D014316:Tritium; D010208:Papaverine