Radioiodinated antibody to carcinoembryonic antigen: binding to normal and cancerous human colon in vitro.
Samples of tumor and normal mucosa from 32 patients with adenocarcinoma of the colorectum were examined for their capacity to bind radioiodinated antibody to carcinoembryonic antigen (anti-CEA) lgG. Twenty-three (72%) of the tumors bound significantly more antibody than the respective normal mucosa. The results indicate that radiolabeled anti-CEA may be useful in the in vivo localization of CEA-producing tumors and metastases in man, and may have application in vitro as a diagnostic marker of precancerous change in colorectal biopsies from patients at risk of developing colorectal cancer.
D000230:Adenocarcinoma / Q000276:immunology*; D000912:Antibodies, Neoplasm; D000937:Antigen-Antibody Reactions; D002272:Carcinoembryonic Antigen / Q000032:analysis; D003106:Colon / Q000276:immunology*; D003110:Colonic Neoplasms / Q000276:immunology*; D006801:Humans; D007074:Immunoglobulin G; D007413:Intestinal Mucosa / Q000276:immunology; D011863:Radioimmunoassay; D012004:Rectal Neoplasms / Q000276:immunology*
D000912:Antibodies, Neoplasm; D002272:Carcinoembryonic Antigen; D007074:Immunoglobulin G