Distribution of 3H-uridine-5 in rat brain areas after exposure to various training tasks - an autoradiographic analysis.
Operant schedules were used to isolate components of a training task and the distribution of radioactivity into various brain areas was studied using high resolution autoradiography. Rats exposed to a visual stimulus change showed more labelling in hippocampal area CA1 than littermates exposed to no stimulus change. Rats exposed to a non-cued contingency change showed higher labelling in hippocampal areas CA2 and CA4 than littermates exposed to a cued contingency change. The results suggest that hippocampal changes in RNA synthesis may be related more to the aversive conditions of the training task than to specific learning changes.
D000818:Animals; D001345:Autoradiography; D001921:Brain / Q000378:metabolism*; D001923:Brain Chemistry; D005108:Extinction, Psychological; D006624:Hippocampus / Q000378:metabolism; D007858:Learning / Q000502:physiology*; D008297:Male; D009044:Motor Cortex / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains; D012055:Reinforcement Schedule; D014529:Uridine / Q000378:metabolism*; D014793:Visual Cortex / Q000378:metabolism
D014529:Uridine