Translation of polysomal messenger RNA during epidermal differentiation.
Translation in vitro of messenger RNA obtained from preparations of active polysomes isolated from the epidermal basal, spinous, and granular cells of the newborn rat has provided evidence that in the context of differentiation in this tissue, control of protein synthesis is exerted at the level of transcription. The data supporting this hypothesis are reviewed.
D000596:Amino Acids / Q000032:analysis; D000818:Animals; D001345:Autoradiography; D002454:Cell Differentiation; D002845:Chromatography; D004247:DNA / Q000096:biosynthesis*; D005815:Genetic Code; D008854:Microscopy, Electron; D011132:Polyribosomes / Q000032:analysis / Q000378:metabolism*; D014176:Protein Biosynthesis; D012333:RNA, Messenger / Q000032:analysis / Q000378:metabolism*; D051381:Rats; D012270:Ribosomes / Q000648:ultrastructure; D012867:Skin / Q000032:analysis* / Q000166:cytology; D014158:Transcription, Genetic; D014316:Tritium / Q000032:analysis; D014461:Ultracentrifugation
D000596:Amino Acids; D012333:RNA, Messenger; D014316:Tritium; D004247:DNA