The action of arachidonic acid on the locomotive activity of mice.
The intraperitoneal administration of methyl or sodium arachidonate (100 and 200 mg-kg causes, in mice, a significant decline in locomotive activity 30 min later, and is able to oppose completely the antagonistic action of D-amphetamine (2.5 and 5 mg-kg). This effect seems to be related to increased synthesis of prostaglandins, for it disappears partially after pretreatment with acetylsalicylic acid, which alone has no effect on the spontaneous activity of mice. Oleic acid, an unsaturated fatty acid not involved in prostaglandin synthesis does not give significant results in the same conditions.
D000661:Amphetamine / Q000494:pharmacology; D000818:Animals; D001095:Arachidonic Acids / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D001241:Aspirin / Q000494:pharmacology; D008297:Male; D051379:Mice; D009043:Motor Activity / Q000187:drug effects*; D009829:Oleic Acids / Q000494:pharmacology
D001095:Arachidonic Acids; D009829:Oleic Acids; D000661:Amphetamine; D001241:Aspirin