Induction of temporary sterility in female hamsters by an intraperitoneal silastic-PVP-PGF2alpha tube.
In the female hamster, temporary sterility for a period of 10 or 15 days was induced by an intraperitoneal Silastic-PVP-tube containing 3.5 or 1.0 mg of PGF2alpha, respectively. All Silastic-PVP-PGF2alpha tube hearing animals regained fertility and delivered normal litters at various times after the placement of the tube. The release rate of 3-H-PGF2alpha from the Silastic-PVP tube was described and their potential use as a drug delivery system discussed.
D000818:Animals; D006224:Cricetinae; D003864:Depression, Chemical; D005260:Female; D005298:Fertility / Q000187:drug effects; D007247:Infertility, Female / Q000139:chemically induced*; D007440:Intubation; D008098:Litter Size / Q000187:drug effects; D010537:Peritoneum; D011205:Povidone; D011247:Pregnancy; D011460:Prostaglandins F / Q000008:administration & dosage / Q000378:metabolism / Q000494:pharmacology*; D012826:Silicone Elastomers
D011460:Prostaglandins F; D012826:Silicone Elastomers; D011205:Povidone