Substance P and spinal neurones.
When applied by microiontophoresis, substance P (sP) had a strong, but slow and prolonged excitatory action on nearly half the neurones tested in the lumbar spinal cord of cats. Motoneuronal antidromic field potentials only occasionally showed a significant effect of sP. Cerebral cortical neurones in cats and rats were much less readily excited than spinal interneurones. Some unresponsive units showed evidence of a depressant effect of sP. Although sP may have a significant function in central afferent pathways, it is not likely to be a quickly-acting synaptic transmitter.
D000085:Acetates / Q000494:pharmacology; D000109:Acetylcholine / Q000494:pharmacology; D000818:Animals; D002415:Cats; D003655:Decerebrate State; D003864:Depression, Chemical; D004305:Dose-Response Relationship, Drug; D007395:Interneurons / Q000187:drug effects; D007478:Iontophoresis; D008839:Microelectrodes; D009046:Motor Neurons / Q000187:drug effects; D009431:Neural Conduction / Q000187:drug effects*; D010812:Physical Stimulation; D011863:Radioimmunoassay; D051381:Rats; D012970:Sodium Glutamate / Q000494:pharmacology; D013116:Spinal Cord / Q000187:drug effects*; D013268:Stimulation, Chemical; D013373:Substance P / Q000494:pharmacology*; D013997:Time Factors; D005680:gamma-Aminobutyric Acid / Q000494:pharmacology
D000085:Acetates; D013373:Substance P; D005680:gamma-Aminobutyric Acid; D000109:Acetylcholine; D012970:Sodium Glutamate