Measles vaccine in dogs: efficacy against aerosol challenge with virulent canine distemper virus.
Fifty young Beagle pups were used in studies on the efficacy of measles virus vaccine in providing protection against virulent canine distemper (CD) virus given intranasally. Among 29 dogs vaccinated with measles virus vaccine and subsequently exposed to virulent CD virus, 1 died, 7 developed relatively severe signs of CD, 15 had mild signs of distemper, and 6 remained clinically normal. Of 15 unvaccinated dogs similarly exposed to virulent CD virus, 11 succumbed to distemper. Six pups vaccinated with modified live-virus (MLV) CD virus vaccine remained clinically normal following immunity challenge.
D000281:Administration, Intranasal; D000336:Aerosols; D000818:Animals; D000855:Anorexia / Q000662:veterinary; D001835:Body Weight; D003967:Diarrhea / Q000662:veterinary; D004216:Distemper / Q000276:immunology / Q000517:prevention & control*; D004217:Distemper Virus, Canine / Q000276:immunology; D004285:Dogs; D004751:Enteritis / Q000662:veterinary; D005334:Fever / Q000662:veterinary; D007273:Injections, Intramuscular; D008458:Measles Vaccine / Q000008:administration & dosage; D008459:Measles virus / Q000276:immunology; D009500:Neutralization Tests; D014765:Viral Vaccines / Q000008:administration & dosage
D000336:Aerosols; D008458:Measles Vaccine; D014765:Viral Vaccines