Specific carcinogenic effect of N-methyl-N-nitrosourea on the midventral sebaceous gland of the gerbil (Meriones unguiculatus).
Gerbils (Meriones unguiculatus), given N-methyl-N-nitrosourea iv once weekly for 15 weeks at doses related to the mean lethal dose, developed tumors of the species-specific midventral sebaceous gland. These neoplasms were more frequent in males than females and were histologically classified as sebaceous adenomas or carcinomas of varying differentiation.
D000236:Adenoma / Q000139:chemically induced* / Q000473:pathology; D000818:Animals; D002277:Carcinoma / Q000139:chemically induced* / Q000473:pathology; D005260:Female; D005849:Gerbillinae; D007275:Injections, Intravenous; D007928:Lethal Dose 50; D008297:Male; D008770:Methylnitrosourea / Q000008:administration & dosage / Q000633:toxicity*; D009374:Neoplasms, Experimental / Q000139:chemically induced / Q000473:pathology; D009607:Nitrosourea Compounds / Q000633:toxicity*; D012626:Sebaceous Gland Neoplasms / Q000139:chemically induced* / Q000473:pathology; D012737:Sex Factors
D009607:Nitrosourea Compounds; D008770:Methylnitrosourea