A novel mechanism for inhibition of beta-oxidation by methylenecyclopropylacetyl-CoA, a metabolite of hypoglycin.
D000105:Acetyl Coenzyme A / Q000031:analogs & derivatives / Q000494:pharmacology*; D000409:Alanine / Q000031:analogs & derivatives* / Q000378:metabolism; D000818:Animals; D002087:Butyrates / Q000378:metabolism; D002331:Carnitine / Q000378:metabolism; D003065:Coenzyme A / Q000031:analogs & derivatives* / Q000378:metabolism; D003521:Cyclopropanes / Q000378:metabolism / Q000494:pharmacology*; D005227:Fatty Acids / Q000378:metabolism*; D007700:Kinetics; D008053:Lipid Mobilization / Q000187:drug effects*; D008930:Mitochondria, Liver / Q000187:drug effects / Q000378:metabolism*; D010088:Oxidoreductases / Q000037:antagonists & inhibitors*; D010101:Oxygen Consumption / Q000187:drug effects; D051381:Rats; D013329:Structure-Activity Relationship; D013997:Time Factors; D014118:Toxins, Biological / Q000378:metabolism / Q000494:pharmacology*
D002087:Butyrates; D003521:Cyclopropanes; D005227:Fatty Acids; D014118:Toxins, Biological; D000105:Acetyl Coenzyme A; D010088:Oxidoreductases; D000409:Alanine; D002331:Carnitine; D003065:Coenzyme A