Failure of neutrophilia to increase the number of neutrophils entering a peritoneal exudate in mice.
Neutrophilia, produced by bleeding or by parasitic infection, did not result in a larger than normal number of cells migrating into endotoxin-induced peritoneal exudates. These results fail to support but do not disprove the concept that neutrophil loss from the blood may be controlled primarily by changes in the fractional turnover rate rather than by blood pool size. They indicate that the failure of exudate neutrophils to increase in proportion to blood neutrophils in patients with chronic myeloid leukemia may not be an abnormality as interpreted previously.
D000818:Animals; D001202:Ascitic Fluid / Q000166:cytology*; D004731:Endotoxins / Q000494:pharmacology; D005260:Female; D007274:Injections, Intraperitoneal; D007958:Leukocyte Count; D007964:Leukocytosis / Q000209:etiology / Q000473:pathology*; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D008811:Mice, Inbred DBA; D009349:Nematode Infections / Q000150:complications; D009504:Neutrophils; D013997:Time Factors
D004731:Endotoxins