Spontaneous motility and distribution of prostaglandins in different segments of human Fallopian tubes.
The "in vitro" spontaneous magnitude and stability with time of the isometric developed tension (IDT) and frequency of contractions of ampullar longitudinal and ampullar circular as well as isthmic longitudinal and isthmic circular muscle, from human Fallopian tubes, were explored. The effects of polyphloretin-phosphate (PPP), an inhibitor of prostaglandins (PG), upon the IDT and frequency of different tubal segments, were also explored. We looked for PGE, and F2alpha in extracts of ampullar and isthmic tubal segments. The initial IDT and frequency (recorded at 10 minutes following equilibration) as well as the stability with time (explored afterward during 40 minutes) were comparable among all the preparations, with the exception of the isthmic longitudinal muscle, which suffered a progressive decrement of IDT. PPP inhibited significantly the IDT of the isthmic circular muscle but had no effect upon the ampullar circular muscle. Whereas PGF2alpha was frequently detected in extracts from the isthmic region, those from the tubal ampullar region showed the consistent presence of PGE1. The results suggested a possible relationship between isthmic PGF2alpha and its spontaneous motility. Also, the peculiar distribution of PGE1 and PGF2alpha could have some bearing on the regulation of the different functions of isthmic and ampullar regions of human Fallopian tubes.
D005187:Fallopian Tubes / Q000032:analysis* / Q000187:drug effects; D005260:Female; D006801:Humans; D009132:Muscles / Q000187:drug effects / Q000502:physiology; D011121:Polyphloretin Phosphate / Q000494:pharmacology; D011453:Prostaglandins / Q000502:physiology*; D011458:Prostaglandins E / Q000032:analysis / Q000502:physiology; D011460:Prostaglandins F / Q000032:analysis / Q000502:physiology; D013314:Stress, Mechanical; D013997:Time Factors
D011453:Prostaglandins; D011458:Prostaglandins E; D011460:Prostaglandins F; D011121:Polyphloretin Phosphate