[Effects of staphylococcal leucocidin in mice (author's transl)].
After intraperitoneal injections of mice with paraffin-oil and sodium caseinate the numbers of macrophages and granulocytes increased respectively as well in their peritoneal exsudate as in their blood. On the other hand, cyclophosphamide markedly decreased the numbers of leucocytes. All mice were more susceptibel to infections with leucocidin (PVL-R)-positive staphylococci than to those with leucodidin-negative staphylococci of comparable hemolytic properties. Generally, mice with increased numbers of leucocytes were relatively more resistant to the staphylococcal infections. Concentrated PVL-R-leucocidin injected intraperitoneally into mice caused a temporary decrease in the number of leucocytes, especially granulocytes and their phagocytic activity.
D000818:Animals; D002364:Caseins / Q000494:pharmacology; D003520:Cyclophosphamide / Q000494:pharmacology; D006461:Hemolysis; D007274:Injections, Intraperitoneal; D007956:Leukocidins / Q000494:pharmacology*; D007958:Leukocyte Count; D007962:Leukocytes / Q000187:drug effects; D008264:Macrophages / Q000187:drug effects; D051379:Mice; D010232:Paraffin / Q000494:pharmacology; D010587:Phagocytosis / Q000187:drug effects; D013210:Staphylococcus
D002364:Caseins; D007956:Leukocidins; D010232:Paraffin; D003520:Cyclophosphamide
Wirkungen von Staphylokokken-Leukozidin bei Mäusen