Effect of compaction on particle size.
Compressed tablets were prepared on a hydraulic press at several different compaction pressures by a standardized technique, using aspirin, dicalcium phosphate dihydrate, calcium phosphato-carbonate, alumina, and microcrystalline cellulose. All tablets except microcrystalline cellulose contained a cation-exchange resin as disintegrant. The particle-size spectra of the disintegrating compacts were evaluated using a particle-size counter or an air jet sieve. It is shown that compacts made from different materials but of the same initial particle-size spectra disintegrate to give particles of a considerably different size. Determination of the change in particle size produced by the compaction process provides useful insight into the nature of the compaction process.
D000535:Aluminum; D001241:Aspirin; D002130:Calcium Phosphates; D002254:Carbonates; D002482:Cellulose; D010087:Oxides; D010316:Particle Size; D011312:Pressure; D013607:Tablets
D002130:Calcium Phosphates; D002254:Carbonates; D010087:Oxides; D013607:Tablets; D002482:Cellulose; D000535:Aluminum; D001241:Aspirin