Indomethacin, ketoprofen and corpus luteum regression in the guinea-pig.
1 The accelerated regression of the corpora lutea normally produced by glass beads inserted unilaterally into the uterus of the guinea-pig early in the oestrous cycle was prevented when the beads were filled with indomethacin or ketoprofen. 2 Luteal regression was enhanced by the placement of beads in both horns of the uterus. When empty beads were placed in one horn of the uterus and drug-filled beads in the other, indomethacin blocked regression in both ovaries whereas ketoprofen was ineffective. 3 Indomethacin probably blocks luteal regression by inhibition of prostaglandin syntheses in the uterus.
D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology*; D001577:Benzophenones / Q000494:pharmacology*; D003338:Corpus Luteum / Q000187:drug effects*; D004971:Estrus; D005260:Female; D005898:Glass; D066298:In Vitro Techniques; D007213:Indomethacin / Q000494:pharmacology*; D007660:Ketoprofen / Q000494:pharmacology*; D011247:Pregnancy; D014599:Uterus / Q000187:drug effects
D000893:Anti-Inflammatory Agents; D001577:Benzophenones; D007660:Ketoprofen; D007213:Indomethacin