Effect of 17alpha-ethinylestradiol on biliary excretion of bile acids.
The effect of 17alpha-ethinylestradiol on biliary bile acids has been investigated. The ratio of cholate to chenodeoxycholate was diminished by the estrogen in cholestyramine-treated rats. With low doses, this effect was due to increased excretion of chenodeoxycholate. With the highest dose, the decreased ratio was due to a reduction in the levels of cholic acid. In the intermediate dosage range, both factors contributed to the decreased ratio. Prolonged treatment with 500 mug daily of 17alpha-ethinylestradiol produced a reduction in the excretory rate of both bile acids in animals treated or not treated with cholestyramine.
D000818:Animals; D001646:Bile / Q000187:drug effects / Q000378:metabolism*; D002635:Chenodeoxycholic Acid / Q000378:metabolism*; D002792:Cholestyramine Resin / Q000494:pharmacology; D002793:Cholic Acids / Q000378:metabolism*; D002849:Chromatography, Gas; D004305:Dose-Response Relationship, Drug; D004958:Estradiol / Q000494:pharmacology; D004997:Ethinyl Estradiol / Q000494:pharmacology*; D005260:Female; D008535:Megestrol / Q000494:pharmacology; D008656:Mestranol / Q000494:pharmacology; D009640:Norethindrone / Q000494:pharmacology; D051381:Rats; D013997:Time Factors
D002793:Cholic Acids; D002635:Chenodeoxycholic Acid; D002792:Cholestyramine Resin; D004997:Ethinyl Estradiol; D004958:Estradiol; D008656:Mestranol; D008535:Megestrol; D009640:Norethindrone