In vitro perfusion of the canine prostate.
An experimental model has been developed for perfusing intact canine prostates in vitro. The glands maintain normal anatomic and histologic appearance and function in a physiologic fashion. Estradiol has been shown to augment testosterone uptake by the prostatic cell. The implications of these findings are discussed.
D000818:Animals; D001345:Autoradiography; D004285:Dogs; D004347:Drug Interactions; D004958:Estradiol / Q000494:pharmacology; D007930:Leucine / Q000378:metabolism; D008297:Male; D008954:Models, Biological; D009924:Organ Culture Techniques; D010477:Perfusion; D011467:Prostate / Q000187:drug effects / Q000378:metabolism* / Q000648:ultrastructure; D013739:Testosterone / Q000378:metabolism*; D014316:Tritium / Q000378:metabolism
D014316:Tritium; D013739:Testosterone; D004958:Estradiol; D007930:Leucine