Inhibitory effect of nickel and chromium upon antibody response of rats to immunization with T-1 phage.
Nickel and chromium significantly depressed the circulating antibody response of rats immunized with a viral antigen (T-1 phage). Consistent suppression of antibody was observed in all metal-treated animals; the greatest decrease in antibody titers was noted in animals receiving metals two weeks prior to the initial antigen dose.
D000818:Animals; D000917:Antibody Formation / Q000187:drug effects*; D002857:Chromium / Q000494:pharmacology*; D003090:Coliphages / Q000276:immunology*; D003864:Depression, Chemical; D005260:Female; D007114:Immunization; D009532:Nickel / Q000494:pharmacology*; D051381:Rats
D002857:Chromium; D009532:Nickel