Oestrogen-induced endometrial carcinoma in a patient with gonadal dysgenesis.
This case report describes the genesis of endometrial carcinoma after prolonged stilboestrol therapy in a patient with gonadal dysgenesis (Turner's syndrome). The varied histological appearance included the presence of cartilage-like material. A review of the literature reveals the need to treat these patients with combined oestrogen/progestogen preparations rather than with continuous unopposed oestrogens.
D000230:Adenocarcinoma / Q000139:chemically induced* / Q000473:pathology; D000328:Adult; D002294:Carcinoma, Squamous Cell / Q000139:chemically induced / Q000473:pathology; D002356:Cartilage; D004054:Diethylstilbestrol / Q000009:adverse effects*; D005260:Female; D006801:Humans; D014424:Turner Syndrome / Q000150:complications* / Q000188:drug therapy; D014594:Uterine Neoplasms / Q000139:chemically induced* / Q000150:complications / Q000473:pathology
D004054:Diethylstilbestrol