Adriamycin-induced cardiac damage in the mouse: a small-animal model of cardiotoxicity.
After one dose of adriamycin, a subacute cardiomyopathy was observed in the mouse by both light and electron microscopy. The microscopic alterations were characterized by single-cell necrosis and mitochondrial degeneration. These lesions were similar to those seen in man and shortly preceded fatal toxicity.
D000818:Animals; D004195:Disease Models, Animal; D004317:Doxorubicin / Q000633:toxicity*; D005260:Female; D006321:Heart / Q000187:drug effects*; D006331:Heart Diseases / Q000139:chemically induced*; D051379:Mice; D008810:Mice, Inbred C57BL; D008811:Mice, Inbred DBA; D008854:Microscopy, Electron; D008931:Mitochondria, Muscle / Q000473:pathology; D009206:Myocardium / Q000473:pathology* / Q000648:ultrastructure; D009336:Necrosis
D004317:Doxorubicin