Determination of the minimum alveolar concentration (MAC) of halothane in the white New Zealand rabbit.
The minimum alveolar concentration (MAC) was determined in rabbits as the mean of the lowest alveolar halothane concentration preventing and the highest permitting a response to stimulus. MAC for the rabbit was 0.8 plus or minus 0.3 per cent. The measurement of MAC in the rabbit appears to reflect the arterial and brain anaesthetic concentrations.
D000769:Anesthesia, Inhalation; D000818:Animals; D002245:Carbon Dioxide / Q000097:blood; D004305:Dose-Response Relationship, Drug; D006221:Halothane / Q000008:administration & dosage* / Q000032:analysis / Q000097:blood; D007442:Intubation, Intratracheal; D008297:Male; D010313:Partial Pressure; D010812:Physical Stimulation; D011650:Pulmonary Alveoli / Q000032:analysis; D011817:Rabbits; D012890:Sleep; D013997:Time Factors; D014110:Touch
D002245:Carbon Dioxide; D006221:Halothane