Hypertonic balanced sodium solution in burn shock.
This study was designed to ascertain the most effective sodium solution for resuscitation after potentially fatal thermal injury. Solutions containing from 75 to 300 mEq/L of sodium were administered in various doses to mice subjected to a standarized scald. Their effectiveness was evaluated by comparison of the 24-hour mortalities, and also by the changes in body weight, urine and plasma electrolytes, etc. A wide range of solutions was effective; the optimal intake was approximately 22.5 mEq of sodium per kilogram of body weight. This was most efficiently given in a solution containing 225 mEq of sodium and 160 mEq of chloride per liter. Survival increased when the sodium to chloride ratio more closely approximated that oe plasma. Hypotonic solutions were less effective at all dosage levels.
D000818:Animals; D002056:Burns / Q000150:complications / Q000378:metabolism / Q000628:therapy*; D004305:Dose-Response Relationship, Drug; D004487:Edema / Q000209:etiology; D005110:Extracellular Space / Q000378:metabolism; D005260:Female; D051379:Mice; D012462:Saline Solution, Hypertonic / Q000008:administration & dosage / Q000627:therapeutic use*; D012769:Shock / Q000628:therapy*; D012964:Sodium / Q000378:metabolism; D012965:Sodium Chloride / Q000627:therapeutic use*; D014882:Water-Electrolyte Balance
D012462:Saline Solution, Hypertonic; D012965:Sodium Chloride; D012964:Sodium