Responses of isolated human basilar arteries to 5-hydroxytryptamine, noradrenaline, serum, platelets, and erythrocytes.
The isolated human basilar artery suspended in Kreb's solution contracts to 5-hydroxy-tryptamine, noradrenaline, and histamine, which stimulate specific receptors. Normal human serum contains an unidentified contractile substance, and erythrocytes relax the artery. Serum and erythrocytes potentiate 5-HT contractions. This preparation is suitable for studying vasoactive substances released during vasospasm after subarachnoid haemorrhage.
D000293:Adolescent; D000328:Adult; D001488:Basilar Artery / Q000187:drug effects*; D001769:Blood; D001792:Blood Platelets / Q000502:physiology; D002555:Cerebrospinal Fluid / Q000502:physiology; D004912:Erythrocytes / Q000502:physiology; D006801:Humans; D002546:Ischemic Attack, Transient / Q000097:blood / Q000209:etiology; D009119:Muscle Contraction / Q000187:drug effects; D009130:Muscle, Smooth / Q000187:drug effects; D009638:Norepinephrine / Q000494:pharmacology*; D011955:Receptors, Drug / Q000187:drug effects; D012701:Serotonin / Q000494:pharmacology*; D013345:Subarachnoid Hemorrhage / Q000150:complications; D014666:Vasomotor System / Q000187:drug effects*
D011955:Receptors, Drug; D012701:Serotonin; D009638:Norepinephrine