Role of sulfhydryl groups in cellular adhesiveness.
Aggregation of chick embryonic liver and kidney cells was completely abolished by a treatment with carboxypyridine disulfide which binds -SH groups. The effect could be reversed by a subsequent treatment with some thiols. Inhibition of RNA synthesis or respiratory metabolism did not prevent cell aggregation. Cell adhesion is discussed in the light of these observations.
D000818:Animals; D001386:Azides / Q000494:pharmacology; D002448:Cell Adhesion / Q000187:drug effects; D002449:Cell Aggregation / Q000187:drug effects; D002642:Chick Embryo; D003609:Dactinomycin / Q000494:pharmacology; D004220:Disulfides / Q000494:pharmacology; D007668:Kidney / Q000166:cytology / Q000187:drug effects / Q000196:embryology*; D008099:Liver / Q000166:cytology / Q000187:drug effects / Q000196:embryology*; D008433:Mathematics; D009539:Nicotinic Acids / Q000494:pharmacology; D011725:Pyridines / Q000494:pharmacology; D012402:Rotenone / Q000494:pharmacology; D013438:Sulfhydryl Compounds
D001386:Azides; D004220:Disulfides; D009539:Nicotinic Acids; D011725:Pyridines; D013438:Sulfhydryl Compounds; D012402:Rotenone; C001102:6,6'-dithiodinicotinic acid; D003609:Dactinomycin