Accelerated uptake of 5-hydroxytryptamine by human blood platelets enriched in a sialic acid.
The enzymically catalysed incorporation of N-acetylneuraminic acid into human platelets, whether suspended in their own citrated plasma or in buffered saline containing 0.17 mM-sucrose, accelerated the uptake of 5-hydroxytryptamine. This acceleration decreased with time. The observations may be explained by assuming that N-acetylneuraminic acid is a component of a transport receptor for 5-hydroxytryptamine.
D001692:Biological Transport; D001792:Blood Platelets / Q000378:metabolism*; D002384:Catalysis; D012701:Serotonin / Q000097:blood*; D012794:Sialic Acids / Q000494:pharmacology*
D012794:Sialic Acids; D012701:Serotonin