Effect of dietary D-penicillamine on metabolism of copper in the rat.
When normal rats were put on a diet containing d-penicillamine equivalent to a dosage of about 1.75 g/day in a 70-kg man, there was a prompt, marked decrease in biliary excretion of copper and of radiocopper after its intravenous administration. Urinary copper increased as tissue copper levels decreased; this decrease was most pronounced in bone marrow, kidney, lung, and spleen. Plasma copper increased and p-phenylendiamine oxidase activity increased. Fecal copper decreased modestly, which was probably attributable to decreases in food intake and biliary copper. Copper-toxic rats, already hypercupriuric, excreted more urinary copper when given d-penicillamine.
D000818:Animals; D001646:Bile / Q000032:analysis; D001853:Bone Marrow / Q000378:metabolism; D003300:Copper / Q000097:blood / Q000378:metabolism* / Q000506:poisoning / Q000652:urine; D004032:Diet; D004435:Eating; D005243:Feces / Q000032:analysis; D007668:Kidney / Q000378:metabolism; D008168:Lung / Q000378:metabolism; D008297:Male; D010396:Penicillamine / Q000494:pharmacology*; D051381:Rats; D013154:Spleen / Q000378:metabolism; D013997:Time Factors
D003300:Copper; D010396:Penicillamine