Neurotoxicity of topically applied hexachlorophene in the young rat.
Young rats 6 to 22 days of age are extremely susceptible to the neurotoxic effects of hexachlorophene given as a daily bath of undiluted antiseptic detergent containing 3% hexachlorophene (pHiso-Hex). At this age, most rats are clinically and histologically damaged by as few as two daily baths. Younger rats are relatively resistant, probably because they have less myelin to be affected; older rats cannot be poisoned by this route, probably because the more mature liver excretes the drug more effectively. Age-dose-response curves in rats are similar to those in humans. This experimental model is potentially useful in defining other characteristics of this drug.
D000287:Administration, Topical; D000367:Age Factors; D000818:Animals; D000831:Animals, Newborn; D001921:Brain / Q000473:pathology; D001927:Brain Diseases / Q000139:chemically induced* / Q000401:mortality; D001933:Brain Stem / Q000473:pathology; D002531:Cerebellum / Q000473:pathology; D004305:Dose-Response Relationship, Drug; D005106:Exploratory Behavior / Q000187:drug effects; D005247:Feeding Behavior / Q000187:drug effects; D006582:Hexachlorophene / Q000008:administration & dosage / Q000633:toxicity*; D006801:Humans; D007231:Infant, Newborn; D007232:Infant, Newborn, Diseases / Q000473:pathology; D008854:Microscopy, Electron; D009186:Myelin Sheath / Q000187:drug effects / Q000254:growth & development / Q000473:pathology; D051381:Rats
D006582:Hexachlorophene