Hypolipidemic imidazoles.
A series of analogs of N-benzylimidazole was prepared and tested for hypolipidemic activity. Both plasma cholesterol and triglyceride-lowering activity were found in several members of the series. The most active compounds were N-3-methoxy-, N-4-methoxy-, and N-4-methylbenzylimidazole. Structure-activity relationships are discussed.
D000818:Animals; D002784:Cholesterol / Q000097:blood / Q000378:metabolism; D003864:Depression, Chemical; D000960:Hypolipidemic Agents / Q000138:chemical synthesis*; D007093:Imidazoles / Q000138:chemical synthesis* / Q000494:pharmacology; D008099:Liver / Q000378:metabolism; D008297:Male; D051379:Mice; D013329:Structure-Activity Relationship; D014280:Triglycerides / Q000097:blood / Q000378:metabolism
D000960:Hypolipidemic Agents; D007093:Imidazoles; D014280:Triglycerides; D002784:Cholesterol