Nicotine-induced hypophagia and hypodipsia in deprived and in hypothalamically stimulated rats.
Nicotine, in doses of 0.15 and 0.45 mg/kg, induced hypophagia and hypodipsia in 20 hrs-deprived rats and elevated the threshold currents for hypothalamically induced feeding and drinking in satiated rats. These effects were blocked by pretreatment with 0.5 mg/kg mecamylamine, but not by pretreatment with 3.0 or 9.0 mg/kg hexamethonium. These results indicate a centrally-located mechanism for the hypophagic and hypodipsic effect of single injections of nicotine.
D000818:Animals; D003864:Depression, Chemical; D004327:Drinking Behavior / Q000187:drug effects*; D004558:Electric Stimulation; D005247:Feeding Behavior / Q000187:drug effects*; D005508:Food Deprivation; D006584:Hexamethonium Compounds / Q000494:pharmacology; D007031:Hypothalamus / Q000502:physiology*; D008297:Male; D008464:Mecamylamine / Q000494:pharmacology; D009538:Nicotine / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D051381:Rats; D014868:Water Deprivation
D006584:Hexamethonium Compounds; D008464:Mecamylamine; D009538:Nicotine