[Characteristics of the energy metabolism in the kidneys in analgesic nephropathy].
Effect of prolonged treatment with acetyl salicylic acid (100 mg/kg) on energy metabolism was studied in dog kidney. Functional conditions of kidney were altered, which was manifested by an increase in excretion of sodium and by impairement is osmotic concentrating of urine. Studies of energy metabolism revealed uncoupling of oxidation and phosphorylation and also some decrease in the activity of glycolytic processes. The observed alterations in bioenergetics of kidney tissue are considered as important factors in development of analgetic nephropathy.
D000284:Administration, Oral; D000818:Animals; D001241:Aspirin / Q000009:adverse effects*; D004285:Dogs; D004734:Energy Metabolism; D007668:Kidney / Q000378:metabolism*; D007671:Kidney Concentrating Ability; D007672:Kidney Cortex / Q000166:cytology; D007674:Kidney Diseases / Q000139:chemically induced*; D007677:Kidney Function Tests; D007679:Kidney Medulla / Q000166:cytology; D008297:Male; D008928:Mitochondria / Q000378:metabolism; D009997:Osmotic Pressure; D010085:Oxidative Phosphorylation; D010101:Oxygen Consumption; D011048:Polarography; D012964:Sodium / Q000652:urine; D013997:Time Factors
D012964:Sodium; D001241:Aspirin
Osobennosti énergeticheskogo obmena v pochkakh pri anal'geticheskoĭ nefropatii