Abnormal hemoglobin synthesis in some leukemic patients.
Hemoglobin chain synthesis during leukemic processes has been studied on patients having fetal hemoglobin. All cases showed the following abnormalities : (1) a relatively increased synthesis of the beta chain ; (2) an important increase of the free dimeric precursors pool, with, most of the time, a predominance of alpha chain. If the first point suggests an alpha-thalassemia feature, the presence of free alpha chains shows evidence for a more complex mechanism not only due to a decrease of messenger RNA. The hypothesis of a clonal disorder could neither be demonstrated nor ruled out. The observed abnormalities could be due to a defect in a alpha chain depending regulation mechanism.
D002250:Carbon Radioisotopes; D002850:Chromatography, Gel; D005319:Fetal Hemoglobin / Q000096:biosynthesis; D005914:Globins / Q000096:biosynthesis; D006455:Hemoglobins, Abnormal / Q000096:biosynthesis*; D006801:Humans; D007930:Leucine / Q000378:metabolism; D007938:Leukemia / Q000097:blood*; D008239:Lysine / Q000378:metabolism; D012156:Reticulocytes / Q000378:metabolism; D014316:Tritium
D002250:Carbon Radioisotopes; D006455:Hemoglobins, Abnormal; D014316:Tritium; D005914:Globins; D005319:Fetal Hemoglobin; D007930:Leucine; D008239:Lysine