Transplacental effects of diethylnitrosamine in Syrian hamsters as related to different days of administration during pregnancy.
Female Syrian hamsters were given a single sc dose of 45 mg diethylnitrosamine (DEN)/kg body weight on 1 of the 15 days of pregnancy. In the offspring of females treated on 1 of the first 11 days of pregnancy, no respiratory tract tumors were found. The offspring of mothers given DEN on 1 of the last 4 days (12-15) of pregnancy developed respiratory tract neoplasms at a rate of up to 95%. A lower incidence of tumors in other organs seemed independent of the day of DEN treatment.
D000818:Animals; D006224:Cricetinae; D004052:Diethylnitrosamine / Q000008:administration & dosage; D005260:Female; D005865:Gestational Age; D008297:Male; D008431:Maternal-Fetal Exchange; D009374:Neoplasms, Experimental / Q000139:chemically induced; D009602:Nitrosamines; D011247:Pregnancy; D012142:Respiratory Tract Neoplasms / Q000139:chemically induced*
D009602:Nitrosamines; D004052:Diethylnitrosamine