Studies on absorption and elimination of drugs. Part III. Kinetic of distribution and elimination of 2-p-methoxy- and 2-p-bromophenylindandione-1,3 in rabbits.
Distribution and elimination constants, half-times, plasma clearance and volume of distribution for 2-p-methoxy (AID) and 2-p-bromophenylindandione-1,3 (Br-PID) were estimated, basing on a two-compartment open pharmacokinetic models. Differences were found when similar processes of distribution and elimination of PID and its p- chloro, bromo and methoxy derivatives were compared.
D000818:Animals; D000840:Anisoles; D000925:Anticoagulants / Q000008:administration & dosage; D001711:Biotransformation; D001969:Bromobenzenes; D055598:Chemical Phenomena; D002621:Chemistry; D007189:Indans / Q000008:administration & dosage / Q000378:metabolism*; D007192:Indenes / Q000378:metabolism*; D007700:Kinetics; D008433:Mathematics; D008657:Metabolic Clearance Rate; D011485:Protein Binding; D011817:Rabbits; D013997:Time Factors
D000840:Anisoles; D000925:Anticoagulants; D001969:Bromobenzenes; D007189:Indans; D007192:Indenes