Influence of therapeutic concentrations of phenylbutazone on granulocyte function.
The influence of therapeutic concentrations of phenylbutazone on human granulocyte function has been examined using a method which facilitates a precise in vitro evaluation of the phagocytic and bactericidal activities of polymorphonuclear leucocytes. Phenylbutazone caused a marked reduction in intracellular killing of bacteria by the granulocytes. Whether this inhibition of granulocyte function also takes place in vivo resulting in enhanced susceptibility to infection, remains unknown.
D003864:Depression, Chemical; D006098:Granulocytes / Q000187:drug effects*; D006801:Humans; D007962:Leukocytes / Q000187:drug effects*; D010587:Phagocytosis / Q000187:drug effects; D010653:Phenylbutazone / Q000494:pharmacology*; D013210:Staphylococcus; D013997:Time Factors
D010653:Phenylbutazone