[Malformations and abnormality of the sex ration after hormone treatment in mice (author's transl)].
Ovulation was induced in 90 randomly-bred virgin mice (Swiss albino) by the i.p. injection of 5 I.U. pregant mare's serum and human chorionic gonadotropin, respectively, with an interval of 48 hours between injections. Pregnancy occurred in 32 animals following normal fertilization. Caesarian section was generally performed on account of blocked delivery and the progeny placed with foster mothers. A statistically-significant shift in the sex ration (to the disadvantage of the males) was observed. The incidence of malformations of the extremities was significantly higher than in a control group. In comparison with control embryos which were also born by Caesarian section, the chance of survival of the progeny of hormone-injected females appeared distinctly reduced. A possible correlation between hormone-induced ovulation and abnormalities in the progeny is discussed in this paper.
D000014:Abnormalities, Drug-Induced / Q000453:epidemiology*; D000818:Animals; D006063:Chorionic Gonadotropin / Q000008:administration & dosage / Q000009:adverse effects*; D005260:Female; D005313:Fetal Death / Q000139:chemically induced; D005552:Forelimb / Q000002:abnormalities; D005799:Genes, Dominant; D005804:Genes, Lethal; D006064:Gonadotropins, Equine / Q000008:administration & dosage / Q000009:adverse effects*; D007274:Injections, Intraperitoneal; D008297:Male; D051379:Mice; D009154:Mutation; D010060:Ovulation / Q000187:drug effects; D011247:Pregnancy; D012744:Sex Ratio; D013094:Spermatozoa / Q000187:drug effects
D006063:Chorionic Gonadotropin; D006064:Gonadotropins, Equine
Missbildungen und Störung des Geschlechtsverhältnisses nach Hormonbehandlung bei Mäusen