Absorption of phenobarbital after the intramuscular administration of single doses in infants.
Blood concentrations of phenobarbital, following an intramuscular administration of a single large dose of approximately 10 mg/kg, were studied in 39 infants. A rapid rise was obtained with a mean concentration of 9.30 mug/ml at 30 minutes, 12.76 mug/ml at 90 minutes, and a mean peak concentration of 13.28 mug/ml, which was reached in most cases within 2 hours of injection or less. Cerebrospinal fluid values in 13 patients averaged half the blood phenobarbital concentrations.
D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007273:Injections, Intramuscular; D010634:Phenobarbital / Q000008:administration & dosage* / Q000097:blood / Q000134:cerebrospinal fluid; D013997:Time Factors
D010634:Phenobarbital