On the racemization of L-noradrenaline bitartrate.
The hydronium ion catalyzed racemization of L-noradrenaline bitartrate solutions was studied as a function of ionic strength and polarity of the medium. On the grounds of the findings obtained, it was assumed that the racemization of the drug involves an ionic reaction between ions of like charge. The water/propylene glycol system dielektric constant 60 was found to furnish optimal stability conditions for the drug. In addition, attention must be given to avoiding the incorporation of electrolytes into the solution.
D004355:Drug Stability; D004573:Electrolytes; D009638:Norepinephrine; D009904:Optical Rotation; D012996:Solutions; D013242:Sterilization; D013644:Tartrates
D004573:Electrolytes; D012996:Solutions; D013644:Tartrates; D009638:Norepinephrine