Effect of pentoxifylline on energy rich phosphates in rat's erythrocytes.
After an oral administration of 5 mg/kg pentoxifylline (3, 7-dimethyl-1-(5-oxo-hexyl)-xanthine, Trental -R) increases significantly total adenine nucleotides content, ATP and AMP, and decreases significantly ADP in rat's erythrocytes. This increased ATP level is likely partly responsible for the therapeutic effect of pentoxifylline in the disturbed peripheral circulation.
D000227:Adenine Nucleotides / Q000097:blood*; D000244:Adenosine Diphosphate / Q000097:blood; D000249:Adenosine Monophosphate / Q000097:blood; D000255:Adenosine Triphosphate / Q000097:blood; D000818:Animals; D004912:Erythrocytes / Q000187:drug effects*; D005260:Female; D006452:Hemoglobinometry; D051381:Rats; D014665:Vasodilator Agents / Q000494:pharmacology*; D014970:Xanthines / Q000494:pharmacology*
D000227:Adenine Nucleotides; D014665:Vasodilator Agents; D014970:Xanthines; D000249:Adenosine Monophosphate; D000244:Adenosine Diphosphate; D000255:Adenosine Triphosphate