Carcinoid myopathy. Serotonin-induced muscle weakness in man?
A myopathy, which improved with cyproheptadine hydrochloride therapy, developed in a patient with carcinoid syndrome of ten years' duration. Biopsy examination revealed advanced atrophy of type II muscle fibers, with type I fiber preponderance. Many of the small fibers had degenerated. Carcinoid myopathy may be due to excess circulating serotonin.
D000328:Adult; D002276:Carcinoid Tumor / Q000150:complications* / Q000503:physiopathology; D003533:Cyproheptadine / Q000627:therapeutic use; D004576:Electromyography; D005260:Female; D006801:Humans; D007414:Intestinal Neoplasms / Q000150:complications* / Q000503:physiopathology; D009132:Muscles / Q000473:pathology / Q000648:ultrastructure; D009135:Muscular Diseases / Q000188:drug therapy / Q000209:etiology* / Q000473:pathology; D012701:Serotonin / Q000378:metabolism*; D013577:Syndrome
D003533:Cyproheptadine; D012701:Serotonin