Effect of surfactants on absorption through membranes IV: effects of dioctyl sodium sulfosuccinate on absorption of a poorly absorbable drug, phenolsulfonphthalein, in humans.
To explore the effect of dioctyl sodium sulfosuccinate on drug absorption in humans, the urinary excretion of a poorly absorbable drug, phenolsulfonphthalein, administered in solution with and without the surfactant was determined. Coadministration of a therapeutic dose of the surfactant with the drug solution resulted in a significant increase in the initial rate of absorption. A small increase in the extent of absorption was also observed. Pretreatment with the surfactant for 6 nights, followed by administration of the drug on the 7th day, did not significantly change the rate of extent of absorption. The surfactant is thought to have a direct effect on the GI membrane, resulting in a temporary change in its permeability. This effect appears to be reversible after a few hours.
D000328:Adult; D004305:Dose-Response Relationship, Drug; D004357:Drug Synergism; D006801:Humans; D007408:Intestinal Absorption / Q000187:drug effects*; D008297:Male; D010635:Phenolphthaleins / Q000378:metabolism*; D010637:Phenolsulfonphthalein / Q000378:metabolism* / Q000652:urine; D013501:Surface-Active Agents / Q000009:adverse effects / Q000494:pharmacology*; D013997:Time Factors
D010635:Phenolphthaleins; D013501:Surface-Active Agents; D010637:Phenolsulfonphthalein