Cardias arrhythmias in hypoxic rabbits during aerosol propellant inhalation.
Rabbits were exposed for four minutes to combinations of oxygen (21%, 11%, or 7%) and fluorocarbon-11 (0%, 5%, or 15%). Exposure to 7% oxygen-15% fluorocarbon-11 caused cardiac arrhythmias in all rabbits exposed. These bradyarrhythmias developed at levels of arterial hypoxemia that did not cause arrhythmias in rabbits exposed to 7% oxygen alone. In contrast with recent reports, hypoxia and this aerosol propellant do appear to have an interactive effect on cardiac rhythm.
D000335:Aerosol Propellants / Q000633:toxicity*; D000336:Aerosols / Q000633:toxicity*; D000818:Animals; D001145:Arrhythmias, Cardiac / Q000209:etiology*; D001693:Biological Transport, Active; D001794:Blood Pressure / Q000187:drug effects; D001919:Bradycardia / Q000209:etiology; D004347:Drug Interactions; D004562:Electrocardiography; D004781:Environmental Exposure; D005465:Fluorocarbon Polymers / Q000633:toxicity*; D005466:Fluorocarbons / Q000494:pharmacology / Q000633:toxicity*; D006329:Heart Conduction System / Q000187:drug effects; D006339:Heart Rate / Q000187:drug effects; D000860:Hypoxia / Q000150:complications*; D008297:Male; D010100:Oxygen / Q000494:pharmacology; D011817:Rabbits
D000335:Aerosol Propellants; D000336:Aerosols; D005465:Fluorocarbon Polymers; D005466:Fluorocarbons; D010100:Oxygen