[Effect of histones on cell permeability, protein and RNA synthesis and RNA stability in Aerobacter cloaceae].
The histones of calf thymus were found to change the permeability of the cells of Aerobacter cloaceae, without producing any noticeable effect on their viability. Concomitant depolymerization of the cellular RNA indicates destruction of the ribosomes. The increased synthesis of RNA in interpreted as a manifestation of reparatory processes. Protein synthesis, virtually unaffected in the resting cells, was inhibited to some extent in the growing culture treated with histones. Some considerations concerning the mode of action of histones at the intracellular level are presented.
D000409:Alanine / Q000378:metabolism; D001426:Bacterial Proteins / Q000096:biosynthesis*; D002463:Cell Membrane Permeability / Q000187:drug effects*; D002470:Cell Survival / Q000187:drug effects; D004754:Enterobacter / Q000187:drug effects* / Q000378:metabolism; D004755:Enterobacteriaceae / Q000187:drug effects*; D006657:Histones / Q000494:pharmacology*; D007930:Leucine / Q000378:metabolism; D009963:Orotic Acid / Q000378:metabolism; D012329:RNA, Bacterial / Q000096:biosynthesis
D001426:Bacterial Proteins; D006657:Histones; D012329:RNA, Bacterial; D009963:Orotic Acid; D007930:Leucine; D000409:Alanine
Vliianie gistonov na kletochnuiu pronitsaemost', sintez belka, RNK i stabil'nost' RNK u Aerobacter cloaceae