Time/dose relationships in experimental radiation cataractogenesis.
The response of the mammalian lens to fractionated radiation exposures was evaluated as a model system for predicting delayed radiation effects on normal tissue. Only the heads of male Ha/ICR mice were irradiated with 14 different time-dose schedules and followed for cataractous changes. A log-log plot of dose vs time yielded a line with a slope of 0.303 and ordinate intercept of 1050 R; a similar plot for dose vs fraction number yielded a slope of 0.382 and ordinate intercept of 835 R. Results suggest that the lenticular response to radiation may be a useful model for studying late effects.
D000818:Animals; D002386:Cataract / Q000209:etiology*; D004307:Dose-Response Relationship, Radiation; D007908:Lens, Crystalline / Q000528:radiation effects*; D008297:Male; D051379:Mice; D011830:Radiation Effects; D013997:Time Factors