Treatment of acute isoniazid toxicity.
The clinical symptoms and treatment of acute isoniazid toxicity are presented. The use of supportive measures and chemotherapy are discussed in detail. The pharmacology and biochemistry underlying the symptons of isoniazid poisoning are aslo presented. It is concluded that diazepam in combination with pyridoxine is the treatment of choice for the management of convulsions associated with isoniazid toxicity. Pyridoxine should be administered intravenously in amounts equal to the estimated quantity of isoniazid ingested, even if seizures have not occurred.
D000138:Acidosis / Q000139:chemically induced / Q000188:drug therapy; D000293:Adolescent; D000328:Adult; D000402:Airway Obstruction / Q000628:therapy; D000927:Anticonvulsants / Q000627:therapeutic use; D001639:Bicarbonates / Q000627:therapeutic use; D003128:Coma / Q000628:therapy; D004231:Diuresis; D005260:Female; D006801:Humans; D007538:Isoniazid / Q000494:pharmacology / Q000506:poisoning* / Q000652:urine; D008297:Male; D011041:Poisoning / Q000188:drug therapy; D011736:Pyridoxine / Q000008:administration & dosage / Q000627:therapeutic use; D012640:Seizures / Q000139:chemically induced; D013405:Suicide
D000927:Anticonvulsants; D001639:Bicarbonates; D011736:Pyridoxine; D007538:Isoniazid