Treatment of hypernatraemic dehydration in infancy.
Thirty-eight infants with severe hyperosmolar dehydration and hypernatraemia were treated, using three regimens of intravenous fluids: A. 1/2 normal saline, given fast; B.1/2 normal saline given slowly; C. 1/5 normal saline. 28 of the infants were studied in a treatment trial, and it is concluded tha 0-18% saline in 4-3% dextrose, with the early addition of potassium given at a rate of 100 ml/kg estimated rehydrated weight per 24 hours gives satisfactory rehydration within 48 hours, with little risk of convulsions.
D001639:Bicarbonates / Q000627:therapeutic use; D001835:Body Weight; D003681:Dehydration / Q000628:therapy*; D005759:Gastroenteritis / Q000150:complications; D006801:Humans; D006943:Hyperglycemia / Q000209:etiology; D006955:Hypernatremia / Q000209:etiology / Q000628:therapy*; D006996:Hypocalcemia / Q000209:etiology; D007223:Infant; D007263:Infusions, Parenteral / Q000009:adverse effects; D009994:Osmolar Concentration; D010634:Phenobarbital / Q000627:therapeutic use; D011188:Potassium / Q000627:therapeutic use / Q000652:urine; D011189:Potassium Chloride / Q000627:therapeutic use; D012140:Respiratory Tract Diseases / Q000150:complications; D012640:Seizures / Q000209:etiology; D018805:Sepsis / Q000150:complications; D012964:Sodium / Q000097:blood / Q000652:urine; D012965:Sodium Chloride / Q000627:therapeutic use; D012996:Solutions
D001639:Bicarbonates; D012996:Solutions; D012965:Sodium Chloride; D011189:Potassium Chloride; D012964:Sodium; D011188:Potassium; D010634:Phenobarbital