Incompatibility of diphenhydramine hydrochloride (Benadryl) with meglumine iodipamide (Cholografin).
Diphenhydramine hydrochloride (Benadryl) and meglumine iodipamide (Cholografin) were mixed in varying proportions and found to consistently form a dense amorphous precipitate. This is not mentioned in the package insert of either agent. All physicians who administer these compounds should be aware of this phenomenon.
D002758:Cholangiography / Q000009:adverse effects; D004155:Diphenhydramine / Q000008:administration & dosage* / Q000009:adverse effects / Q000627:therapeutic use; D004344:Drug Incompatibility; D006801:Humans; D007458:Iodipamide / Q000008:administration & dosage* / Q000009:adverse effects
D004155:Diphenhydramine; D007458:Iodipamide