Investigation of some materials as dry binders for direct compression in tablet manufacture. Part 2: Comparative self-binding properties.
Comparative self-binding qualities of four substances studied as potential dry binders for direct compression applications in tablet making were investigated. The effect of particle size of these materials on hardness, friability and hardness-friability ratio of disks made with mere binders was studied. The results showed that for comparable particle sizes, values of hardness-friability ratio of the various disks were in the following descending order: Plasdone, tragacanth, Carbowax 4000 and then mannitol.
D005079:Excipients; D006245:Hardness Tests; D010316:Particle Size; D014677:Pharmaceutical Vehicles; D011312:Pressure; D013607:Tablets; D013678:Technology, Pharmaceutical
D005079:Excipients; D014677:Pharmaceutical Vehicles; D013607:Tablets