Central inhibitory effect of alpha-methyldopa on blood pressure, heart rate and body temperature of renal hypertensive rats.
The central inhibitory effect of alpha-methyldopa on blood pressure, heart rate and body temperature was studied in conscious renal hypertensive rats. Systemic administration of alpha-methyldopa decreased mean arterial blood pressure and body temperature and caused a short lasting increase in heart rate followed by a long lasting decrease. Inhibition of central decarboxylase activity prevented the decrease in blood pressure, heart rate and body temperature but not the initial increase in heart rate. Inhibition of peripheral decarboxylase activity blocked the increase in heart rate and partially reduced the decrease in heart rate and body temperature but did not affect the decrease in blood pressure. Alpha-Methyldopa also decreased blood pressure at an ambient temperature of 30 degrees C, but the decrease of body temperature was absent and the heart rate remained elevated for 7 hr. Similar results were obtained in normotensive rats. The decrease in heart rate was correlated with the decrease in body temperature in normotensive and renal hypertensive rats. These findings suggest that in the renal hypertensive rat the decrease in blood pressure and in body temperature depends on a central action of alpha-methyldopa metabolites.
D000818:Animals; D065105:Aromatic Amino Acid Decarboxylase Inhibitors; D001545:Benserazide / Q000494:pharmacology; D001794:Blood Pressure / Q000187:drug effects*; D001831:Body Temperature / Q000187:drug effects*; D003864:Depression, Chemical; D006339:Heart Rate / Q000187:drug effects*; D006977:Hypertension, Renal / Q000201:enzymology / Q000503:physiopathology; D008297:Male; D008750:Methyldopa / Q000494:pharmacology*; D051381:Rats
D065105:Aromatic Amino Acid Decarboxylase Inhibitors; D008750:Methyldopa; D001545:Benserazide