Effect of glucagon on blood glucose homeostasis in infants of diabetic mothers.
Thirty infants of diabetic mothers (IDM) were randomly selected and divided into 3 groups of 10 babies each. Group A were used as controls. Group B received glucagon 300 mug/kg i.m. and Group C received glucagon 300 mug/kg i.v. at birth. Hypoglycemia developed in 6 infants in Group A and 4 infants in Group B. None of the infants in Group C had hypoglycemia. Mean blood glucose was higher in Group C in the first 3 hours than Group A, and higher in Group B in the first (/2-1 hour. I.v. glucshon, 300 mug/kg when given in the first 15 minutes after birth prevented hypoglycemia in IDM in the first hours of life.
D001034:Apgar Score; D001724:Birth Weight; D001786:Blood Glucose / Q000378:metabolism*; D003920:Diabetes Mellitus / Q000097:blood*; D005260:Female; D005865:Gestational Age; D005934:Glucagon / Q000008:administration & dosage; D006706:Homeostasis; D006801:Humans; D007231:Infant, Newborn; D007273:Injections, Intramuscular; D007275:Injections, Intravenous; D008297:Male; D012737:Sex Factors
D001786:Blood Glucose; D005934:Glucagon