Three dimensional geometry of acutely ischemic myocardium.
The distribution of coronary flow to small segments of the entire left ventricle (96 per dog; average weight = 0.78 g) was studied in 28 open-chested dogs utilizing 7-10 mu labeled microspheres. Although the flow to large areas of the ventricle was nearly evenly distributed, there was considerable heterogeneity of flow to small adjacent segments of myocardium (average standard deviation of the flow distributions was 17.3 +/- 3.2% of mean lfow). Approximately one-half of the measured heterogeneity of flow could be attributed to various extraneous factors, and one-half appears to be due to inherent heterogeneity of flow in the left ventricular myocardium. In ten of 28 dogs, the mid-circumglex coronary was suddenly occluded, and five minutes thereafter the distribution of left ventricular flow was determined with microspheres labeled with a different isotope. The ischemic regments were separated into three groups: severely ischemic, moderately ischemic, and borderline ischemic. The three dimmensional geometry of the acutely ischemic myocardium was analyzed, and four general conclusions were reached. 1) The percent distribution of severely ischemic segments, moderately ischemic segments, and borderline ischemic segments within an ischemic region varies from animal to animal. 2) Subendocardial segments were more frequently and more severely affected than neighboring mid-wall or epicardial segments. 3) No evidence of an "hyperperfused zone" of myocardium surrounding the ischemic area was found. 4) The flows to segments immediately adjacent to the severely ischemic segments were heterogeneous. Therefore, the concept of a geometrically defined "buffer zone" of moderately ischemic myocardium surrounding and separating severely ischemic from normally perfused myocardium no longer seems realistic.
D000818:Animals; D001783:Blood Flow Velocity; D001794:Blood Pressure; D002302:Cardiac Output; D003326:Coronary Circulation; D003327:Coronary Disease / Q000473:pathology* / Q000503:physiopathology; D003331:Coronary Vessels; D004195:Disease Models, Animal; D004285:Dogs; D004562:Electrocardiography; D005260:Female; D006321:Heart / Q000503:physiopathology; D006339:Heart Rate; D008297:Male; D008863:Microspheres; D009206:Myocardium / Q000473:pathology*