Investigation of some materials as dry binders for direct compression in tablet manufacture. Part 4: Effect of disintegrants.
The effects of starch and Veegum as disintegrants on the dry-binding qualities of tragacanth, polyethylene glycol 4000, polyvinylpyrrolidone and mannitol were investigated. The type of diluent and its concentration in the powder blends appeared to influence the binding efficiency of the binders investigated.
D000538:Aluminum Silicates; D002626:Chemistry, Pharmaceutical; D004339:Drug Compounding; D006244:Hardness; D008274:Magnesium; D008353:Mannitol; D010316:Particle Size; D010592:Pharmaceutic Aids; D011092:Polyethylene Glycols; D011134:Polysaccharides; D011205:Povidone; D011312:Pressure; D013213:Starch; D013607:Tablets
D000538:Aluminum Silicates; D010592:Pharmaceutic Aids; D011134:Polysaccharides; D013607:Tablets; D008353:Mannitol; D011092:Polyethylene Glycols; D013213:Starch; D011205:Povidone; D008274:Magnesium