Dose effects of smoked marihuana on human cognitive and motor functions.
Graded doses of marihuana were administered to five adults in a longitudinal repeated-measurements design. Speed of response was the basic parameter measured accross tests of increasing cognitive involvement. Marihuana produced significant dose-response effects of impaired performance in all test scores. However, single automatic motor abilities demonstrated greater sensitivity than tests of greater complexity. Evidence is presented for tolerance development.
D000328:Adult; D002188:Cannabis / Q000494:pharmacology*; D003071:Cognition / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D013759:Dronabinol / Q000494:pharmacology; D004361:Drug Tolerance; D005260:Female; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D008297:Male; D009048:Motor Skills / Q000187:drug effects*; D008517:Phytotherapy; D010919:Placebos; D011930:Reaction Time / Q000187:drug effects; D013404:Suggestion; D013998:Time Perception / Q000187:drug effects; D014936:Word Association Tests
D010919:Placebos; D013759:Dronabinol