The effect of chlordiazepoxide hydrochloride on the isolated perfused rat liver.
The effects of chlordiazepoxide-hydrochloride (CDZ) on the isolated perfused rat liver were examined. CDZ administration decreased bile flow, biliary excretion of sulfobromophthalein (BSP) and hepatic uptake of BSP. The addition of CDZ to the perfusate of livers obtained from phenobarbital (Pb) pretreated rats led to 50% greater reductions in bile flow, concentration of BSP in bile and hepatic uptake of BSP. The adverse effects of CDZ on BSP excretion per g liver, however, did not appear to be enhanced by Pb pretreatment. The complex nature of the interrelationship of the effects of Pb and of CDZ on the control liver prevented differentiation of the role of CDZ from that of a metabolite on the adverse effect on liver function.
D000818:Animals; D001646:Bile / Q000502:physiology; D002707:Chlordiazepoxide / Q000494:pharmacology*; D004357:Drug Synergism; D005260:Female; D066298:In Vitro Techniques; D007274:Injections, Intraperitoneal; D008099:Liver / Q000187:drug effects* / Q000378:metabolism; D008657:Metabolic Clearance Rate; D010477:Perfusion; D010634:Phenobarbital / Q000494:pharmacology; D051381:Rats; D013448:Sulfobromophthalein / Q000378:metabolism
D013448:Sulfobromophthalein; D002707:Chlordiazepoxide; D010634:Phenobarbital