2-Deoxy-D-glucose inhibition of prostaglandin E1 hyperthermia and yeast fever in mice.
2-Deoxy-D-glucose (2-DG) and sodium salicylate were evaluated relative to their effects on body temperature in mice with prostaglandin E1 (PGE1)hyperthermia or yeast fever. Injection of 2-DG into the cerebral ventricles of conscious mice abolished the hyperthermia of PGE1 and reduced the fever produced by yeast, while sodium salicylate was effective only in yeast fever. The data are suggestive of glucose dependency of thermoregulatory centers in the brain.
D000818:Animals; D001831:Body Temperature / Q000187:drug effects*; D001833:Body Temperature Regulation; D002552:Cerebral Ventricles / Q000187:drug effects; D003837:Deoxy Sugars / Q000494:pharmacology*; D003847:Deoxyglucose / Q000494:pharmacology*; D005334:Fever / Q000139:chemically induced / Q000209:etiology / Q000517:prevention & control*; D008297:Male; D051379:Mice; D011458:Prostaglandins E / Q000037:antagonists & inhibitors*; D012980:Sodium Salicylate / Q000494:pharmacology; D013997:Time Factors; D015003:Yeasts
D003837:Deoxy Sugars; D011458:Prostaglandins E; D003847:Deoxyglucose; D012980:Sodium Salicylate