The effect of some antithrombotic drugs on experimental arterial thrombosis.
The model of arterial thrombosis in rats used in this study is especially suitable for testing the preventive effect of antithrombotic drugs. An oral anticoagulant was ineffective in this model. Heparin, streptokinase, acetylsalicylic acid and dipyridamole were only moderately effective whereas highest effectiveness was attained by combining heparin with acetylsalicylic acid.
D000208:Acute Disease; D000818:Animals; D000925:Anticoagulants / Q000627:therapeutic use*; D001158:Arteries; D001241:Aspirin / Q000494:pharmacology / Q000627:therapeutic use; D004176:Dipyridamole / Q000494:pharmacology; D004357:Drug Synergism; D005342:Fibrinolysis / Q000187:drug effects; D006493:Heparin / Q000494:pharmacology / Q000627:therapeutic use; D008954:Models, Biological; D011517:Prothrombin Time; D051381:Rats; D013300:Streptokinase / Q000627:therapeutic use; D013927:Thrombosis / Q000188:drug therapy*
D000925:Anticoagulants; D004176:Dipyridamole; D006493:Heparin; D013300:Streptokinase; D001241:Aspirin