Clearance of middle ear effusions by the mucociliary system.
There are two extreme types of middle ear effusion leading to hearing loss (a) a rubber-like effusion seen in secretory otitis media and (b) a water-like effusion seen in serous otitis media. The possibility is considered that the degree of crosslinking in these two extreme cases is the basis of an altered mucus transport rate that leads to an accumulation of effusions and hence impaired hearing. It has been shown (King et al., 1974) that the requisite rheological property for transport activity is not unique to mucus structural macromolecules but is found with other polymeric systems that are loosely crosslinked e.g. guaran, polyacrylamide, gelatin and agarose. Studies on one of these systems guaran, indicate that the transport rate is dependent on the degree of crosslinking with a maximum rate found close to the gel point, i.e. in a region where there are very few crosslinks per macromolecule. The finding that mucus from different mucociliary epithelial sources involves a chemically similar structural glycoprotein suggests that differences observed in transport rate between various mucus samples are more likely due to differences observed in transport rate between various mucus samples are more likely due to differences in crosslinking than chemical variations of the glycoprotein units.
D000818:Animals; D001001:Anura; D001831:Body Temperature; D002415:Cats; D004432:Ear, Middle / Q000503:physiopathology*; D005122:Exudates and Transudates / Q000378:metabolism; D006023:Glycoproteins / Q000378:metabolism; D006801:Humans; D008970:Molecular Weight; D009092:Mucous Membrane / Q000378:metabolism / Q000503:physiopathology; D010033:Otitis Media / Q000503:physiopathology*
D006023:Glycoproteins