An indirect sympathomimetic effect of burimamide on kitten isolated atria.
1. Burimamide (34-1080 muM) caused a concentration-dependent increase in the force and frequency of contraction of kitten isolated atria. 2. Metiamide (467 muM) had no stimulant action on kitten atria and did not modify the effects of burimamide. 3. The atrial stimulation produced by burimamide was reduced by (-)propranolol (34-68 nM) and by cocaine (3 muM). 4. The atrial stimulant effect of burimamide was prevented by pretreatment of kittens with reserpine (1 mg/kg, 24 h before the experiment). 5. It is concluded that burimamide causes atrial stimulation by releasing catecholamines.
D000818:Animals; D002049:Burimamide / Q000494:pharmacology*; D002415:Cats; D003042:Cocaine / Q000494:pharmacology; D005260:Female; D006325:Heart Atria / Q000187:drug effects; D006339:Heart Rate / Q000187:drug effects; D006632:Histamine / Q000494:pharmacology; D066298:In Vitro Techniques; D008297:Male; D008785:Metiamide / Q000494:pharmacology; D009200:Myocardial Contraction / Q000187:drug effects*; D009638:Norepinephrine / Q000494:pharmacology; D011433:Propranolol / Q000494:pharmacology; D012110:Reserpine / Q000494:pharmacology; D013268:Stimulation, Chemical; D013566:Sympathomimetics / Q000494:pharmacology*; D013890:Thiourea / Q000031:analogs & derivatives*; D014439:Tyramine / Q000494:pharmacology
D013566:Sympathomimetics; D008785:Metiamide; D006632:Histamine; D012110:Reserpine; D011433:Propranolol; D013890:Thiourea; D003042:Cocaine; D002049:Burimamide; D009638:Norepinephrine; D014439:Tyramine