Effects of prostaglandin antagonist SC-19220 on body temperature and on hyperthermic responses to prostaglandin E-1 and leukocytic pyrogen in the cat.
Intravenous injection of SC-19220 (3-9 mg/kg) caused dose-related hypothermic responses in cats. Repeated administration of SC-19220 resulted in tolerance to its hypothermic action. During SC-19220-induced hypothermia, the hyperthermic activity of both prostaglandin E-1 and leukocytic pyrogen was reduced or abolished. Neither prostaglandin E-1 nor leukocytic pyrogen was antagonized when given shortly after recovery from SC-19220-induced hypothermia or by doses of SC-19220 which did not cause hypothermia. Although these results may indicate a role of prostaglandins in normal physiological thermoregulation, it is also possible that production of hypothermia by SC-19220 is unrelated to prostaglandin antagonism.
D000818:Animals; D001831:Body Temperature / Q000187:drug effects*; D002415:Cats; D003864:Depression, Chemical; D004305:Dose-Response Relationship, Drug; D007036:Hypothermia, Induced; D007275:Injections, Intravenous; D011448:Prostaglandin Antagonists / Q000008:administration & dosage / Q000494:pharmacology*; D011458:Prostaglandins E / Q000494:pharmacology; D011749:Pyrogens; D013268:Stimulation, Chemical; D013997:Time Factors
D011448:Prostaglandin Antagonists; D011458:Prostaglandins E; D011749:Pyrogens