Withdrawal rates of DDT from chickens treated with diphenylhydantoin.
Male and female chickens of a broiler-type strain were fed, from 1 day old to 5 weeks of age, diets containing 0, 2.5, or 15.0 p.p.m. (mg/kg) 1,1,1-trichloro-2,2-bis(p-chlorophenyl)ethane (p,p'-DDT). Then the diets with pesticide were withdrawn and the chickens were fed dietary levels of diphenylhydantoin (DPH) at 0, 100, or 250 p.p.m. Adipose-tissue and liver samples were obtained on days 0, 10, 20, and 30 following withdrawal of diets with pesticides to determine DPH effect on DDT, 1,1-dichloro-2,2-bis(p-chlorophenyl)ethylene (DDE), and 1,1-dichloro-2,2-bis(p-chlorophenyl)ethane (DDD) levels. DPH had no effect on the concentration of DDT and DDE in adipose tissue; their levels declined at a rate having a half-life value of 16 days. DDD was not detected in adipose tissue. DDT accounted for 87% of the adipose residues on day 0, but 66% of the residues at day 30. DPH had no effect on the concentrations of DDT and DDE in livers of chickens fed 15.0 p.p.m. DDT, but did significantly reduce the levels of DDD by 28 and 54% for levels of 100 and 250 p.p.m. DPH, respectively. The similarity of these data to studies on dairy cows and humans, and the dissimilarity to data from rat studies were discussed.
D000273:Adipose Tissue / Q000378:metabolism; D000818:Animals; D002645:Chickens; D003634:DDT / Q000378:metabolism*; D003633:Dichlorodiphenyl Dichloroethylene / Q000378:metabolism; D003632:Dichlorodiphenyldichloroethane / Q000378:metabolism; D004026:Dieldrin / Q000378:metabolism; D005260:Female; D006207:Half-Life; D008099:Liver / Q000378:metabolism; D008297:Male; D010672:Phenytoin / Q000494:pharmacology*; D013268:Stimulation, Chemical; D013997:Time Factors
D003633:Dichlorodiphenyl Dichloroethylene; D010672:Phenytoin; D003634:DDT; D004026:Dieldrin; D003632:Dichlorodiphenyldichloroethane