Adenosine as a source for hypoxanthine nucleotides synthesis in human erythrocytes. The effect of dipyridamole.
Incubation of human erythrocytes in the medium containing adenosine, pyruvate and phosphate causes the synthesis of considerable amounts of IMP and ITP. The synthesis of ITP is linear during the 4-hour incubation period. Dipyridamole lowered the synthesis of ITP to a certain extent and greatly increased the synthesis of IMP.
D000227:Adenine Nucleotides / Q000032:analysis; D000241:Adenosine / Q000378:metabolism*; D002852:Chromatography, Ion Exchange; D004176:Dipyridamole / Q000494:pharmacology*; D004912:Erythrocytes / Q000378:metabolism*; D006801:Humans; D007042:Hypoxanthines / Q000032:analysis / Q000096:biosynthesis*; D007292:Inosine Nucleotides / Q000096:biosynthesis; D010710:Phosphates; D011773:Pyruvates; D012965:Sodium Chloride; D013053:Spectrophotometry
D000227:Adenine Nucleotides; D007042:Hypoxanthines; D007292:Inosine Nucleotides; D010710:Phosphates; D011773:Pyruvates; D012965:Sodium Chloride; D004176:Dipyridamole; D000241:Adenosine