Hostility, somatic symptoms and recovery with antidepressants.
Patients were treated with protriptyline or nortriptyline (double-blind). They were assessed on the Zung Depression Scale and on the Hostility and Direction of Hostility Questionnaire (HDHQ). A good response was heralded by low ratings on criticism of self and others,and on projected (paranoid) hostility. The outcome was better with initial low scores on depressive symptoms, particularly unworthiness, restlessness and constipation. As to reported side effects, initial loss of interest augured badly for drowsiness, lack of clear mind for blurred vision, loss of libido for constipation and ideas of suicide for dry mouth.
D003863:Depression / Q000188:drug therapy; D003986:Dibenzocycloheptenes / Q000494:pharmacology*; D006791:Hostility / Q000187:drug effects*; D006801:Humans; D009661:Nortriptyline / Q000494:pharmacology* / Q000627:therapeutic use; D010555:Personality Inventory; D011530:Protriptyline / Q000494:pharmacology* / Q000627:therapeutic use; D011569:Psychiatric Status Rating Scales; D012647:Self-Assessment; D011795:Surveys and Questionnaires
D003986:Dibenzocycloheptenes; D011530:Protriptyline; D009661:Nortriptyline