[Characteristics of hemocoagulation in different periods of the development of a venous intravascular thrombus].
Experiments were conducted on rabbits. A study was made of peculiarities of blood coagulation and of the functional changes in platelets at the period of the thrombus organization, and also at various stages after its formation in the femoral vein. It appeared that at the period of the thrombus formation and during the first 5 minutes after its organization there occurred hypercoagulation changes in the blood and hypocoagulation of the plasma against the background of decrease in fibrinogen, hyperfibrinolysis, hyperheparinemia and thrombocytopenia. One to three days after the thrombosis of the femoral vein the blood hypercoagulation capacity becomes less pronounced. At this time thrombocytosis, an increase in fibrinogen content, hypoheparinemia and inhibition of fibrinolysis are observed. In the authors' opinion, hemocoagulation changes in venous thrombosis were chiefly caused by the hypercoagulation activity of the blood formed elements.
D000818:Animals; D001777:Blood Coagulation; D001792:Blood Platelets; D005268:Femoral Vein; D005340:Fibrinogen / Q000032:analysis; D005342:Fibrinolysis; D006493:Heparin / Q000097:blood; D011817:Rabbits; D013921:Thrombocytopenia / Q000209:etiology; D013927:Thrombosis / Q000097:blood* / Q000150:complications; D013997:Time Factors
D005340:Fibrinogen; D006493:Heparin
Osobennosti gemokoaguliatsii v razlichnye sroki obrazovaniia venoznogo vnutrisosudistogo tromba