Preliminary experience with 15 (S) 15-methyl prostaglandin F2 alpha for midtrimester abortion.
Twenty-six women received intramuscular or intra-amniotic 15 (S) 15-methyl prostaglandin F2 alpha to induce midtrimester abortion. The median initial injection-abortion interval was 10 hours and 25 minutes. The advantages of intramuscular analogue are somnolence and reduced discomfort during labor. Disadvantages include severe gastrointestinal toxicity in the majority of patients and symptoms of acute respiratory distress in two patients.
D000028:Abortion, Induced; D003967:Diarrhea / Q000139:chemically induced; D005260:Female; D006801:Humans; D007273:Injections, Intramuscular; D010121:Oxytocin / Q000494:pharmacology; D011247:Pregnancy; D011262:Pregnancy Trimester, Second; D011453:Prostaglandins / Q000008:administration & dosage / Q000494:pharmacology* / Q000633:toxicity; D012131:Respiratory Insufficiency / Q000139:chemically induced; D013997:Time Factors; D014839:Vomiting / Q000139:chemically induced
D011453:Prostaglandins; D010121:Oxytocin