Immunoglobulins and complement components in synovial fluid of patients with acute rheumatic fever.
Three components of complement and six other serum proteins were assayed in synovial fluid and serum samples from 25 patients with acute rheumatic fever in Trinidad.  The resulting data indicate a relative decrease in both early and late components of complement within the synovial fluids which suggests local activation by immune complexes. Such activation of complement within the joint spaces may play a primary role in development of the  inflammatory arthritis of acute rheumatic fever.
D000293:Adolescent; D000328:Adult; D000418:Albumins / Q000032:analysis; D000936:Antigen-Antibody Complex; D001797:Blood Protein Electrophoresis; D002648:Child; D002675:Child, Preschool; D003172:Complement C1 / Q000032:analysis; D003176:Complement C3 / Q000032:analysis; D003165:Complement System Proteins / Q000032:analysis*; D005260:Female; D006801:Humans; D007070:Immunoglobulin A / Q000032:analysis; D007074:Immunoglobulin G / Q000032:analysis; D007075:Immunoglobulin M / Q000032:analysis; D007136:Immunoglobulins / Q000032:analysis*; D008259:Macroglobulins / Q000032:analysis; D008297:Male; D012213:Rheumatic Fever / Q000097:blood / Q000276:immunology*; D013582:Synovial Fluid / Q000276:immunology*; D013583:Synovial Membrane / Q000276:immunology; D014168:Transferrin / Q000032:analysis
D000418:Albumins; D000936:Antigen-Antibody Complex; D003172:Complement C1; D003176:Complement C3; D007070:Immunoglobulin A; D007074:Immunoglobulin G; D007075:Immunoglobulin M; D007136:Immunoglobulins; D008259:Macroglobulins; D014168:Transferrin; D003165:Complement System Proteins