Lymphocyte blastogenesis induced by potassium chloride extracts of allogeneic breast carcinoma and lymphoid cells.
Lymphocytes from cancer patients and normal individuals demonstrated blastogenesis with allogeneic potassium chloride (3 M KCl) extracts of breast carcinoma cells. Normal individuals reacted with a greater frequency and stronger blastogenic responses to tumor extracts than did breast carcinoma patients; allogeneic extracts may have elicited recognition of normal alloantigens rather than tumor-associated antigens. Normal individuals also responded to 3 M KCl extracts of allogeneic pooled normal leukocytes, normal breast tissue, and other cancers, but did not react to extracts of autologous leukocytes.
D000918:Antibody Specificity; D000951:Antigens, Neoplasm; D001940:Breast / Q000276:immunology; D001943:Breast Neoplasms / Q000276:immunology*; D006801:Humans; D007519:Isoantigens; D007962:Leukocytes / Q000276:immunology; D008213:Lymphocyte Activation; D011189:Potassium Chloride
D000951:Antigens, Neoplasm; D007519:Isoantigens; D011189:Potassium Chloride