Evaluation of carbon-11 labelled phenylglycine and phenylalanine for pancreas scintigraphy.
Carbon-11 (t1/2 equals 20.4 min, beta-+) labelled DL-alpha-phenylalanine and DL-alpha-phenylglycine were administered intravenously to rats and the distribution of the radioactive amino acids over pancreas, liver, spleen, kidneys and blood was measured after several time intervals. From these results the ratios of the concentration in pancreas and liver were calculated and compared with the corresponding ratios from the literature for some 18-F-labelled aromatic amino acids and L-selenomethionine-75-Se. On the basis of this study it appears that DL-alpha-phenylglycine-1-11-C, in spite of a small percentage of the administered dose reaching the pancreas, and DL-alpha-phenylalanine-1-11-C are better suited to pancreas scintigraphy than L-selenomethionine-75-Se.
D000818:Animals; D002250:Carbon Radioisotopes; D005069:Evaluation Studies as Topic; D005461:Fluorine; D005998:Glycine / Q000378:metabolism; D007275:Injections, Intravenous; D007553:Isotope Labeling / Q000379:methods; D007668:Kidney / Q000378:metabolism; D008099:Liver / Q000378:metabolism; D008297:Male; D010179:Pancreas / Q000378:metabolism; D010182:Pancreatic Diseases / Q000175:diagnosis*; D010648:Phenylacetates; D010649:Phenylalanine / Q000378:metabolism; D011868:Radioisotopes; D011877:Radionuclide Imaging; D051381:Rats; D012643:Selenium; D013154:Spleen / Q000378:metabolism
D002250:Carbon Radioisotopes; D010648:Phenylacetates; D011868:Radioisotopes; D005461:Fluorine; D010649:Phenylalanine; D012643:Selenium; D005998:Glycine