Effects of drug vehicles on ocular uptake of tetracycline.
Varying concentrations of tetracycline hydrochloride were topically applied to the rabbit eye in several ophthalmic vehicles. The antibiotic levels in the corneal epithelium, aqueous humor, and lens were markedly elevated by increasing the drug concentration and the drug contact time with the eye. The ocular levels of tetracycline were increased by the vehicle in this ascending order: isotonic saline, 1.4% polyvinyl alcohol, 1% alpha-methylcellulose, and a 6:4 mixture of white petrolatum-mineral oil ointment. Tetracycline hydrochloride as a 2.0% suspension in ointment produced anterior chamber and corneal concentrations for several hours in the range of bacteriostasis for many gram-negative bacteria that occasionally invade the eye.
D000042:Absorption; D000287:Administration, Topical; D000818:Animals; D000867:Anterior Chamber / Q000378:metabolism; D001082:Aqueous Humor / Q000378:metabolism; D001419:Bacteria / Q000187:drug effects; D003315:Cornea / Q000378:metabolism; D004848:Epithelium / Q000378:metabolism; D005123:Eye / Q000378:metabolism*; D007552:Isotonic Solutions; D007908:Lens, Crystalline / Q000378:metabolism; D008747:Methylcellulose / Q000494:pharmacology; D008899:Mineral Oil / Q000378:metabolism; D009824:Ointments; D009883:Ophthalmic Solutions; D010577:Petrolatum / Q000378:metabolism; D014677:Pharmaceutical Vehicles / Q000494:pharmacology*; D011142:Polyvinyl Alcohol / Q000494:pharmacology; D011817:Rabbits; D012965:Sodium Chloride / Q000494:pharmacology; D013752:Tetracycline / Q000008:administration & dosage / Q000378:metabolism* / Q000494:pharmacology
D007552:Isotonic Solutions; D009824:Ointments; D009883:Ophthalmic Solutions; D014677:Pharmaceutical Vehicles; D012965:Sodium Chloride; D010577:Petrolatum; D008899:Mineral Oil; D011142:Polyvinyl Alcohol; D008747:Methylcellulose; D013752:Tetracycline