[Pathomorphological changes in the kidneys in experimental hypothyroidism].
Morphohistochemical changes were studied in the kidneys of rats in experimental hypothyroidism. The latter was induced by subtotal thyroidectomy (observation periods--60 days), feeding of 6-methylthiouracil (observation periods--100 days), feeding of 6-methylthiouracil to thyroidectomized animals (observation periods--7 to 60 days). Animals of all the three groups displayed morphohistochemical signs of disturbance of acid and neutral polysaccharide metabolism in the vaso-stromal structures of the kidneys and also in the glomeruli. The degree of these changes depended directly on the extent and the duration of a hypothyroid condition. The changes described led to development of sclerosis. Among these changes attention was attracted to deposition of calcium salts in the epithelium, chiefly of the distal tubules.
D000818:Animals; D002114:Calcinosis / Q000209:etiology / Q000473:pathology; D007037:Hypothyroidism / Q000150:complications / Q000473:pathology*; D007668:Kidney / Q000473:pathology*; D007678:Kidney Glomerulus / Q000473:pathology; D007686:Kidney Tubules, Distal / Q000473:pathology; D008297:Male; D008779:Methylthiouracil; D011134:Polysaccharides / Q000378:metabolism; D051381:Rats; D013965:Thyroidectomy
D011134:Polysaccharides; D008779:Methylthiouracil
Patomorfologicheskie izmeneniia pochek pri éksperimental'nom gipotireoze