Acute pulmonary edema and plasma kininogen consumption in the adrenaline-treated rat: inhibition by acetylsalicylic acid and resistance to salicylate and indomethacin.
Pulmonary edema and plasma kininogen consumption caused by intravenously administered adrenaline, were inhibited in rats pretreated with acetylsalicylic acid, but not in rats pretreated with indomethacin or sodium salicylate. The possibility of a connection between this edema and mast cell-linked activation of kallikrein by adrenaline is discussed, as well as the possible role of acetylsalicylic acid acting as an acetylating inhibitor of these processes.
D000818:Animals; D001241:Aspirin / Q000494:pharmacology*; D004351:Drug Resistance; D004837:Epinephrine / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D007213:Indomethacin / Q000494:pharmacology*; D007704:Kininogens / Q000097:blood*; D008297:Male; D011654:Pulmonary Edema / Q000378:metabolism*; D051381:Rats; D012459:Salicylates / Q000494:pharmacology*
D007704:Kininogens; D012459:Salicylates; D001241:Aspirin; D007213:Indomethacin; D004837:Epinephrine