Some pharmacological effects of prodolic acid, a new anti-inflammatory compound, indicative of inhibition of prostaglandin synthesis.
Prodolic acid, a new non-steroidal anti-inflammatory compound, inhibited bradykinin-induced bronchoconstriction but did not affect histamine-induced bronchoconstriction in the guinea pig. Prodolic acid potentiated the responses of the isolated rabbit vas deferens and portal vein to electrical stimulation without altering the response to noradrenaline. The potentiating effects of prodolic acid on the vas deferens were reversible but the potentiating effects in the portal vein were frequency-dependent. It is concluded that these effects of prodolic acid are probably related to its ability to inhibit prostaglandin biosynthesis.
D000403:Airway Resistance / Q000187:drug effects; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology*; D001920:Bradykinin / Q000037:antagonists & inhibitors; D001980:Bronchi / Q000187:drug effects*; D003250:Constriction; D003864:Depression, Chemical; D004558:Electric Stimulation; D006168:Guinea Pigs; D006632:Histamine / Q000494:pharmacology; D066298:In Vitro Techniques; D007210:Indoleacetic Acids; D007211:Indoles / Q000494:pharmacology*; D008297:Male; D011169:Portal Vein / Q000502:physiology; D011453:Prostaglandins / Q000096:biosynthesis; D011714:Pyrans / Q000494:pharmacology; D011817:Rabbits; D013268:Stimulation, Chemical; D014649:Vas Deferens / Q000187:drug effects / Q000502:physiology
D000893:Anti-Inflammatory Agents; D007210:Indoleacetic Acids; D007211:Indoles; D011453:Prostaglandins; D011714:Pyrans; D006632:Histamine; D001920:Bradykinin; C009795:prodolic acid