Sphincter patency and hepatic BSP uptake after biliary sphincterotomy.
An attempt has been made to assess the patency and function of the choledochoduodenal junction after biliary sphincterotomy by estimating the first arrival time of injected bromsulphalein (BSP) in duodenal aspirate and the effect of morphine on this. Studies on 49 patients 1--12 years after this operation showed the arrival time to be normal in 47, but in 2 cases there was delay, which suggests that stenosis may develop in time in abot 4 per cent of cases. This had not been detected clinically, radiologically, or by liver function testing. Although it did not effect the BSP arrival time in T-tube bile, morphine was found to prolong the duodenal arrival time in control patients and also after sphincterotomy of the type used, indicating that the protective mechanism of the sphincter region may not have been destroyed by this operation. Abnormal BSP retention in plasma has been reported up to 5 years afte supraduodenal exploration of the bile ducts in 30 per cent of cases. Similarly, in the present study after biliary sphincterotomy plasma BSP levels were above normal in 14 of 49 patients, suggesting that this abnormality reflects the original pathological condition rather than the type of operation used to deal with it.
D002763:Cholecystectomy; D003135:Common Bile Duct / Q000502:physiology*; D004386:Duodenum / Q000378:metabolism / Q000502:physiology*; D042882:Gallstones / Q000503:physiopathology; D006801:Humans; D008099:Liver / Q000378:metabolism; D009020:Morphine / Q000494:pharmacology; D011183:Postoperative Complications; D009803:Sphincter of Oddi / Q000601:surgery; D013448:Sulfobromophthalein / Q000097:blood
D013448:Sulfobromophthalein; D009020:Morphine