[Comparative Chemotherapeutical studies on the effect of Bactrim and other combined preparations on the proliferative and cystforming phase of Toxoplasma gondii in NMRI mice. A contribution to experimental chemotherapy of toxoplasmosis (author's transl)].
In the present paper, the efficacy of different sulphonamides and potentiators alone and in combination (BACTRIM, FANSIDAR) in mice infected with Toxoplasma gondii is evaluated. The experimental chemotherapeutical studies were performed in mice either freshly infected with trophozoites or cystozoites, or suffering from acute disease or a chronic infection; For the components (see article) a proportion of 10 times 1 turned out to be the most effective mixing ratio. In comparison with the standard combination of sulphamethoxypyrazine times pyrimethamine sharing the best degree of activity, the therapeutic effect of a combination of sulphadoxine times pyrimethamine (components of FANSIDAR) in a proportion of 20 times 1 was either the same or less, depending on the experimental design. The duration of therapy was found to be decisive for the therapeutic result. If it is too short the parasite will return to the cyst stage; Even at low dosage, the components of FANSIDAR, sulphadoxine and pyrimethamine in combination, are capable of acting upon all forms of the proliferative multiplication phase and the cyst formation phase, inclusive of young cysts, and eliminated them completely from the host organism.
D000208:Acute Disease; D000818:Animals; D002908:Chronic Disease; D004338:Drug Combinations; D004341:Drug Evaluation; D004357:Drug Synergism; D005260:Female; D051379:Mice; D011739:Pyrimethamine / Q000627:therapeutic use; D013420:Sulfamethoxazole / Q000627:therapeutic use*; D013449:Sulfonamides / Q000627:therapeutic use; D013997:Time Factors; D014123:Toxoplasmosis / Q000188:drug therapy*; D014295:Trimethoprim / Q000627:therapeutic use*
D004338:Drug Combinations; D013449:Sulfonamides; D014295:Trimethoprim; D013420:Sulfamethoxazole; D011739:Pyrimethamine
Vergleichende chemotherapeutische Untersuchungen über die Wirksamkeit von BACTRIM und anderen Kombinationspräparaten auf die proliferative und Zystenbildungsphase von Toxoplasma gondii in NMRI-Mäusen. Ein weiterer Beitrag zur experimentellen Chemotherapie der Toxoplasmose