Selection of a reference partitioning system for drug design work.
Consideration of the structural, polar, and transport properties of water-saturated solvent and solvent-saturated water phases of three general and eight specific binary systems leads to the conclusion that the n-octanol-water system is a very good all-round compromise for use as a reference system for biological partitioning in drug design work.
D000438:Alcohols; D055598:Chemical Phenomena; D002621:Chemistry; D004952:Esters; D009682:Magnetic Resonance Spectroscopy; D004364:Pharmaceutical Preparations; D012995:Solubility; D012997:Solvents; D013055:Spectrophotometry, Infrared; D013696:Temperature; D013816:Thermodynamics; D014783:Viscosity; D014867:Water
D000438:Alcohols; D004952:Esters; D004364:Pharmaceutical Preparations; D012997:Solvents; D014867:Water