Teratologic evaluation of synthetic delta-9-tetrahydrocannabinol in rats.
Delta-9-Tetrahydrocannabinol (THC) was dissolved in propylene glycol and 25, 50, or 100 mg/kg administereed dialy sc to pregnant Charles River Sprague-Dawley rats on days 6-15 of gestation (presence of sperm considered day 1). Maternal weight gain was depressed, but a significant decrease in fetal weight occurred only in the 50 mg/kg group. No malformations were noted, only some abnormalities consisting of several instances of rudimentary 14th rib and soft or spongy spinal cords.
D000014:Abnormalities, Drug-Induced / Q000209:etiology*; D000818:Animals; D001835:Body Weight / Q000187:drug effects; D002188:Cannabis / Q000009:adverse effects*; D013759:Dronabinol / Q000009:adverse effects*; D005260:Female; D005865:Gestational Age; D011247:Pregnancy; D051381:Rats; D012272:Ribs / Q000002:abnormalities / Q000187:drug effects; D013116:Spinal Cord / Q000002:abnormalities / Q000187:drug effects; D013723:Teratogens / Q000009:adverse effects*
D013723:Teratogens; D013759:Dronabinol