[Breath acetone and ketonemia in normal- and overweight subjects during total fasting (author's transl)].
In subjects of ideal weight (7 males and 7 females) total whole blood ketones and breath acetone were determined during a 6 day fast, and in obese subjects (8 males, 18 females) during 6-28 days of fasting. Development of starvation ketosis was significantly slower in overweight than in normal weight subjects. Breath acetone concentration was up to blood ketone levels of 4 mMol/1 a linear function of the blood ketone concentration, beyond that level, however, an additional exponential component became apparent. The highest acetone elimination found was 4.46 mg/min, corresponding to 6.4 g acetone and 11.2 g acetoacetic acid in 24 hours. Hence the decarboxylation of acetoacetic acid to acetone may be an additional mechanism for the lowering of ketoacidosis in starvation.
D000096:Acetone / Q000032:analysis*; D000328:Adult; D000388:Air / Q000032:analysis; D001835:Body Weight; D005215:Fasting; D005260:Female; D006801:Humans; D007659:Ketones / Q000097:blood*; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000097:blood / Q000378:metabolism*; D012119:Respiration; D013997:Time Factors
D007659:Ketones; D000096:Acetone
Aceton in der Atemluft und Ketone im Venenblut bei vollständigem Fasten normal-und übergewichtiger Personen