The chemistry of local anaesthetic agents: classification of blocking agents.
Compounds with local anaesthetic properties may be classified according to their action upon the nerve membrane. Four classes of agent are recognized: A. Compounds acting at the exterior of the sodium channels; B. Compounds acting at the axoplasmic part of the sodium channels; C. Compounds acting through a physicochemical mechanism; BC. Compounds acting by a combination of B and C mechanisms. The chemical basis for these different mechanisms is discussed.
D000779:Anesthetics, Local / Q000145:classification* / Q000378:metabolism / Q000494:pharmacology; D001566:Benzocaine / Q000494:pharmacology; D001593:Benzyl Compounds / Q000494:pharmacology; D001665:Binding Sites / Q000187:drug effects; D001667:Binding, Competitive / Q000187:drug effects; D002462:Cell Membrane / Q000187:drug effects; D008012:Lidocaine / Q000494:pharmacology; D008958:Models, Molecular; D009431:Neural Conduction / Q000187:drug effects; D009441:Neurilemma / Q000187:drug effects*; D010634:Phenobarbital / Q000494:pharmacology; D010636:Phenols / Q000494:pharmacology; D012530:Saxitoxin / Q000494:pharmacology; D012964:Sodium / Q000378:metabolism; D013329:Structure-Activity Relationship; D013388:Succinimides / Q000494:pharmacology; D013779:Tetrodotoxin / Q000494:pharmacology
D000779:Anesthetics, Local; D001593:Benzyl Compounds; D010636:Phenols; D013388:Succinimides; D012530:Saxitoxin; D013779:Tetrodotoxin; D008012:Lidocaine; D012964:Sodium; D001566:Benzocaine; D010634:Phenobarbital