The conversion of cholest-5-en-3beta-ol into cholest-7-en-3beta-ol by the echinoderms Asterias rubens and Solaster papposus.
1. The echinoderms Asterias rubens and Solaster papposus (Class Asteroidea) metabolize injected [4(-14)C]cholest-5-en-3beta-ol to produce labelled 5alpha-cholestan-3beta-ol and 5alpha-cholest-7-en-3beta-ol. 2. Conversion of 5alpha-[4(-14)C]cholestan-3beta-ol into 5alpha-cholest-7-en-3beta-ol was demonstrated in A. Rubens. 3. Incubations of A. rubens with [4(-14)C]cholest-4-en-3-one resulted in the production of labelled 5alpha-cholestan-3-one, 5alpha-cholestan-3beta-ol and 5alpha-cholest-7-en-3beta-ol. 4. [4(-14)C]Sitosterol was metabolized by A. rubens to give 5alpha-stigmastan-3beta-ol and 5alpha-stigmast-7-en-3beta-ol. 5. The significance of these results in relation to the presence of alpha7 sterols in starfish is discussed.
D000818:Animals; D002778:Cholestanones / Q000378:metabolism; D002782:Cholestenes / Q000378:metabolism; D002784:Cholesterol / Q000378:metabolism*; D012855:Sitosterols / Q000378:metabolism; D013215:Starfish / Q000378:metabolism; D013265:Stigmasterol / Q000378:metabolism
D002778:Cholestanones; D002782:Cholestenes; D012855:Sitosterols; D002784:Cholesterol; D013265:Stigmasterol