Age differences affecting induction of hepatic drug metabolizing enzymes by methaqualone and phenobarbital in the rat.
Methaqualone pretreatment for 3 or 6 days caused an induction of hepatic enzymes in the young male rat as measured by a reduction in hexobarbital-hypnosis. However, methaqualone pretreatment had no effect on the hexobarbital-hypnotic response in older male rats. Phenobarbital was a more potent enzyme inducer than methaqualone, and caused induction of liver enzymes in both age groups.
D000367:Age Factors; D000818:Animals; D004790:Enzyme Induction / Q000187:drug effects; D006591:Hexobarbital / Q000037:antagonists & inhibitors / Q000494:pharmacology; D008099:Liver / Q000187:drug effects / Q000201:enzymology*; D008297:Male; D008702:Methaqualone / Q000494:pharmacology*; D009929:Organ Size / Q000187:drug effects; D010634:Phenobarbital / Q000494:pharmacology*; D051381:Rats; D012890:Sleep / Q000187:drug effects; D013997:Time Factors
D008702:Methaqualone; D006591:Hexobarbital; D010634:Phenobarbital