Influence of fibrinogen degradation products (FDP) on the central nervous system and on the effects of centrally acting drugs.
Fibrinogen degradation products (FDP) from bovine fibrinogen were obtained in vitro by trypsin digestion for 3 and 120 min, respectively. FDP-120 min applied i.p. and i.v.c. stimulated the CNS, while FDP-3 min did not. The FDP increased the potency of amphetamine, caffeine, thiopental, and chlorpromazine by enhancing their level in the brain. Peptides from 120 min digestion were more effective. A possible mechanism of observed changes has been discussed.
D000661:Amphetamine / Q000494:pharmacology*; D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects; D002110:Caffeine / Q000494:pharmacology*; D002490:Central Nervous System / Q000187:drug effects*; D002746:Chlorpromazine / Q000494:pharmacology*; D003864:Depression, Chemical; D005337:Fibrin / Q000378:metabolism / Q000494:pharmacology; D005340:Fibrinogen / Q000378:metabolism* / Q000494:pharmacology; D008297:Male; D051381:Rats; D013268:Stimulation, Chemical; D013874:Thiopental / Q000494:pharmacology*; D013997:Time Factors
D002110:Caffeine; D005337:Fibrin; D005340:Fibrinogen; D000661:Amphetamine; D013874:Thiopental; D002746:Chlorpromazine