Regulation of succinic dehydrogenase activity of heart mitochondria by anti-arrhythmic drugs.
It was observed that either propranolol or iproveratril could increase the succinate oxidation activity by rat heart mitochondria to 444% and to 371% respectively. Both drugs decreased the respiratory control coefficient and ADP/O ratio. No effect on mitochondrial succinic dehydrogenase, succinic dehydrogenase-Co Q-reductase and malic dehydrogenase was observed. It was pointed out that these drugs would act preventing the reoxidation of NADH+ + H+ through the respiratory chain.
D000596:Amino Acids / Q000378:metabolism; D000818:Animals; D000889:Anti-Arrhythmia Agents / Q000494:pharmacology*; D002417:Cattle; D066298:In Vitro Techniques; D008291:Malate Dehydrogenase / Q000378:metabolism; D008931:Mitochondria, Muscle / Q000201:enzymology*; D009206:Myocardium / Q000201:enzymology* / Q000648:ultrastructure*; D010071:Oxaloacetates / Q000378:metabolism; D010085:Oxidative Phosphorylation / Q000187:drug effects; D010088:Oxidoreductases / Q000378:metabolism; D010101:Oxygen Consumption / Q000187:drug effects; D011433:Propranolol / Q000494:pharmacology; D051381:Rats; D013385:Succinate Dehydrogenase / Q000378:metabolism*; D014700:Verapamil / Q000494:pharmacology
D000596:Amino Acids; D000889:Anti-Arrhythmia Agents; D010071:Oxaloacetates; D011433:Propranolol; D014700:Verapamil; D010088:Oxidoreductases; D008291:Malate Dehydrogenase; D013385:Succinate Dehydrogenase