Effect of fluocinolone acetonide cream on human skin blood flow.
Blood flow rate was measured in the forearm skin of human subjects exposed to ultraviolet irradiation. Blood flow was determined by the 133Xe disappearance technique 18 hr after ultraviolet (UV) irradiation with a Westinghouse RS sunlamp held 10 inches from the skin for 10 min. Ultraviolet irradiation caused skin blood flow to increase. Application of fluocinolone acetonide cream, 0.025%, 4 times in the 16 hr following UV irradiation had no effect on either control skin blood flow or the UV-induced hyperemia.
D000287:Administration, Topical; D000328:Adult; D001783:Blood Flow Velocity; D004890:Erythema / Q000209:etiology / Q000503:physiopathology*; D005260:Female; D005446:Fluocinolone Acetonide / Q000008:administration & dosage / Q000494:pharmacology*; D006801:Humans; D008297:Male; D011832:Radiation Injuries / Q000503:physiopathology*; D012039:Regional Blood Flow / Q000187:drug effects*; D012867:Skin / Q000098:blood supply* / Q000187:drug effects / Q000528:radiation effects; D014466:Ultraviolet Rays / Q000009:adverse effects; D014980:Xenon Radioisotopes
D014980:Xenon Radioisotopes; D005446:Fluocinolone Acetonide