Ligand-exchange chromatography of alkaloids.
Alkaloids are separated by liquid chromatography on resins having functional carboxyl groups combined with copper (II) ions. The eluent is aqueous alcohol containing ammonia. Some resins retain alkaloids much better than others. Alkaloids studied included morphine, codeine, strychnine, atropine, papaverine, narcotine, cocaine, quinine, cinchonine and methadone.
D000470:Alkaloids / Q000032:analysis*; D001285:Atropine / Q000032:analysis; D002852:Chromatography, Ion Exchange / Q000379:methods*; D002929:Cinchona / Q000031:analogs & derivatives / Q000032:analysis; D002930:Cinchona Alkaloids; D003042:Cocaine / Q000032:analysis; D003061:Codeine / Q000032:analysis; D003300:Copper; D006868:Hydrolysis; D007475:Ion Exchange Resins; D008691:Methadone / Q000032:analysis; D008722:Methods; D009020:Morphine / Q000032:analysis; D009665:Noscapine / Q000032:analysis; D010208:Papaverine / Q000032:analysis; D010946:Plants, Medicinal; D011803:Quinine / Q000032:analysis; D013331:Strychnine / Q000032:analysis
D000470:Alkaloids; D002930:Cinchona Alkaloids; D007475:Ion Exchange Resins; D009020:Morphine; D003300:Copper; D001285:Atropine; D009665:Noscapine; D011803:Quinine; D010208:Papaverine; D013331:Strychnine; D003042:Cocaine; D008691:Methadone; D003061:Codeine; C010086:cinchonine