Synthesis and properties of 7-hydroxyalkyl-8-benzylaminotheophyllines.
The synthetic routes leading to 7-beta-hydroxyethyl- (I) and 7-beta-hydroxypropyl-8-benzylaminotheophylline (II) were described. Particularly the opening of oxazolidine ring in easy available oxazolidine-(2,3-f)-theophyllines with benzylamine was investigated. The structure of I, II and acetyl derivatives Ia, Ib, IIa and IIb was also confirmed by UV spectra.
D000818:Animals; D007928:Lethal Dose 50; D051379:Mice; D013056:Spectrophotometry, Ultraviolet; D013806:Theophylline / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000633:toxicity
D013806:Theophylline