Strain differences during intraventricular infusion of norepinephrine: possible role of receptor sensitivity.
Two rat strains previously shown to differ with respect to behavioral activity, regional brain tyrosine hydroxylase activity, and norepinephrine-elicited accumulation of adenosine 3', 5'-monophosphate exhibited differential behavioral responsiveness during the intraventricular infusion of norepinephrine. The results are interpreted in terms of differential catecholamine receptor sensitivity.
D000661:Amphetamine / Q000494:pharmacology; D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects; D001921:Brain / Q000187:drug effects / Q000378:metabolism*; D002404:Catheterization; D002552:Cerebral Ventricles; D008297:Male; D008729:Methoxamine / Q000494:pharmacology; D009043:Motor Activity; D009638:Norepinephrine / Q000008:administration & dosage / Q000378:metabolism* / Q000494:pharmacology; D051381:Rats; D011915:Rats, Inbred BUF / Q000378:metabolism*; D011916:Rats, Inbred F344 / Q000378:metabolism*; D011919:Rats, Inbred Strains / Q000378:metabolism*; D011941:Receptors, Adrenergic; D013045:Species Specificity
D011941:Receptors, Adrenergic; D000661:Amphetamine; D008729:Methoxamine; D009638:Norepinephrine