Sex dependent toxicity of four chemicals.
Toxicity investigations were conducted with 4 chemicals: hydrazine, 1,2-dimethylhydrazine di HCl, phenylhydrazine HCl and Beta-N-(gamma-L(+)-glutamyl)-4-hydroxymethylphenylhydrazine in Swiss mice. Hydrazine and phenylhydrazine HCl were administered daily in drinking water, the former at 0.01% and the latter at 0.001% concentrations. The 1,2-dimethylhydrazine di HCl and Beta-N-(gamma-L(+)-glutamyl)-4-hydroxymethylphenylhydrazine were given as a single subcutaneous injection at 45 mug and 100 mug/gr. body weight basis, respectively. The findings clearly showed that all four chemicals exerted a stronger toxic effect in male than in female mice. It is, therefore, recommended in similar situations to use different doses of chemicals for each sex in the long-term tumorigenesis studies.
D000818:Animals; D001835:Body Weight / Q000187:drug effects; D004127:Dimethylhydrazines / Q000494:pharmacology / Q000633:toxicity*; D004327:Drinking Behavior / Q000187:drug effects; D005260:Female; D006834:Hydrazines / Q000494:pharmacology / Q000633:toxicity*; D008297:Male; D051379:Mice; D010659:Phenylhydrazines / Q000494:pharmacology / Q000633:toxicity*; D012737:Sex Factors
D004127:Dimethylhydrazines; D006834:Hydrazines; D010659:Phenylhydrazines