The effect of drugs on the electrical and mechanical activity of the isolated porcine stomach.
Electrical and mechanical activity was recorded from totally isoltted porcine stomachs perfused with homologous blood, The electrical control activity, response activity, and mechanical reaction to various hormones and drugs stimulationg these activities were recorded. The drugs were injected directly into the gastric artery of the isolated organ. Normal response to cholinergic stimulants and to pentagastrin was observed. The effect of blockers such as atropine, hexamethonium and tetrodotosin on the action of stimulants was also assessed. The results of this study suggest that the release of acetylcholine is involved in the mechanism of action of pentagastrin. They also demonstrate the usefulness of the isolated porcine stomach approach to the study of gastric myoelectrical and mechanical activity.
D000109:Acetylcholine / Q000378:metabolism; D000200:Action Potentials; D000818:Animals; D001285:Atropine / Q000494:pharmacology; D004558:Electric Stimulation; D005260:Female; D006584:Hexamethonium Compounds / Q000494:pharmacology; D008297:Male; D010418:Pentagastrin / Q000494:pharmacology; D013270:Stomach / Q000187:drug effects*; D013552:Swine; D013779:Tetrodotoxin / Q000494:pharmacology; D014630:Vagus Nerve / Q000502:physiology
D006584:Hexamethonium Compounds; D013779:Tetrodotoxin; D001285:Atropine; D010418:Pentagastrin; D000109:Acetylcholine