Effects of levodopa on the bladder outlet.
Lower urinary tract function was studied in patients with Parkinson's disease. A significant proportion of patients receiving levodopa manifested clinical and radiological evidence of bladder outlet obstruction. We believe that neuropharmacologic bladder neck obstruction may be caused by the alpha-adrenergic properties of the metabolites of levodopa.
D015102:3,4-Dihydroxyphenylacetic Acid / Q000494:pharmacology; D000368:Aged; D004298:Dopamine / Q000494:pharmacology; D005260:Female; D006719:Homovanillic Acid / Q000494:pharmacology; D006801:Humans; D007980:Levodopa / Q000009:adverse effects*; D008297:Male; D008875:Middle Aged; D010300:Parkinson Disease / Q000150:complications* / Q000188:drug therapy; D014513:Ureter / Q000601:surgery; D001743:Urinary Bladder / Q000473:pathology / Q000601:surgery; D001748:Urinary Bladder Neck Obstruction / Q000139:chemically induced*; D014554:Urination / Q000187:drug effects
D015102:3,4-Dihydroxyphenylacetic Acid; D007980:Levodopa; D004298:Dopamine; D006719:Homovanillic Acid