Mechanism of action of anti-influenza benzamidine derivatives.
Benzamidine derivatives exhibited a high antiviral effect in vivo against influenza virus strains A2/Adachi and B/Lee. The inhibiting properties of anti-influenza benzamidine derivatives on the virus-induced inflammation undoubtedly plays an important role in the clarification of the mechanism of action of these drugs.
D000578:Amidines / Q000494:pharmacology*; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology; D000998:Antiviral Agents / Q000494:pharmacology* / Q000627:therapeutic use; D001550:Benzamidines / Q000494:pharmacology* / Q000627:therapeutic use; D002642:Chick Embryo; D008297:Male; D051379:Mice; D009975:Orthomyxoviridae / Q000187:drug effects*; D009976:Orthomyxoviridae Infections / Q000188:drug therapy; D051381:Rats; D014779:Virus Replication / Q000187:drug effects
D000578:Amidines; D000893:Anti-Inflammatory Agents; D000998:Antiviral Agents; D001550:Benzamidines