[Cardiovascular and hemodynamic effects of derivatives of metoclopramide].
Two salicylamides, thiapride and sultopride, were found to provoke a dose-related depressor effect in the anesthetized dog. This effect was qualitatively similar to that of procaïnamide and metoclopramide. The hypotensive and negative inotropic effects were not related to the parasympathic system. In fact these compounds are weak autonomic antagonists. They do not exert any anticholinesterase activity. Intra-arterial administration provoked vasodilation.
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D002800:Cholinesterase Inhibitors / Q000494:pharmacology; D004285:Dogs; D004562:Electrocardiography; D005260:Female; D006339:Heart Rate / Q000187:drug effects; D006439:Hemodynamics / Q000187:drug effects*; D008297:Male; D008787:Metoclopramide / Q000031:analogs & derivatives* / Q000494:pharmacology; D009200:Myocardial Contraction / Q000187:drug effects; D011342:Procainamide / Q000494:pharmacology; D012119:Respiration / Q000187:drug effects; D014655:Vascular Resistance / Q000187:drug effects
D002800:Cholinesterase Inhibitors; D011342:Procainamide; D008787:Metoclopramide
Effets cardiovasculaire et hémodynamiques de dérivés du métoclopramide