Hydroxypyruvate as a gluconeogenic substrate in rat hepatocytes.
At concentrations of 2mM and above hydroxypyruvate produced no glucose with isolated rat liver cells, although it was rapidly utilized. At a lower concentration of hydroxypyruvate or in the presence of substrates which generate reducing equivalents (ethanol or butyrate), appreciable amounts of glucose were formed from hydroxypyruvate. A possible explanation for this phenomenon is discussed.
D000818:Animals; D002087:Butyrates / Q000378:metabolism; D000431:Ethanol / Q000378:metabolism; D005260:Female; D005943:Gluconeogenesis; D005947:Glucose / Q000096:biosynthesis; D066298:In Vitro Techniques; D008099:Liver / Q000378:metabolism*; D011773:Pyruvates / Q000378:metabolism*; D051381:Rats
D002087:Butyrates; D011773:Pyruvates; D000431:Ethanol; D005947:Glucose