Effect of dantrolene sodium on spasticity associated with hemiplegia.
The effects of dantrolene sodium (Dantrium) were studied in 23 patients with hemiplegic spasticity, 13 of whom were younger than 50, and 10 older than 50. The dosage of dantrolene ranged from 100 mg per day initially to 600 mg per day maximally. The drug was most effective in reducing or abolishing clonus and somewhat less efficacious in decreasing  the resistance to stretch and the tendon reflexes. Functionally, gait was improved and the patients found it easier to take care of their personal needs. In general, motor performance was improved. The observation that patients in the 50+ age group responded less well remains unexplained. Dantrolene sodium is a valuable tool in the management of spasticity due to hemiplegia.
D000328:Adult; D000368:Aged; D003620:Dantrolene / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D005221:Fatigue / Q000139:chemically induced; D005500:Follow-Up Studies; D005684:Gait; D006429:Hemiplegia / Q000150:complications* / Q000209:etiology; D006801:Humans; D006827:Hydantoins / Q000627:therapeutic use*; D008875:Middle Aged; D012026:Reflex, Stretch; D013035:Spasm / Q000188:drug therapy* / Q000209:etiology
D006827:Hydantoins; D003620:Dantrolene