[Effect of Bencyclane on regional cerebral circulation.  Quantitative local measurement of cerebral circulation in healthy persons and patients with cerebrovascular insufficiency, awake or in light general anesthesia].
The effect of intravenous continuous drip infusion of Bencyclan (8mg/min) on regional cerebral blood flow was investigated in 30 adult patients, using the intraarterial 133-Xe-clearance-method and a 10-detector-equipment.  The application of Bencyclan in 5 persons with normal cerebral circulation entailed no significant change of rCBF.  In 5 from 15 patients with cerebrovascular disease in the awake state continuous drip infusion of Bencyclan caused a decrease of global and regional cerebral blood flow with reduction of the regional flow values about 15.3 to 28.4 p.c.  In 10 patients there was seen no statistical significant change of regional cerebral blood flow as compared with the flow values in the resting state.  In 10 patients rCBF-examinations were performed prior and after intravenous injection of Bencyclan in a state of a very light nitrous-oxide-halothan analgesia.  In all patients Bencyclan caused an overall decrease of cerebral blood flow about 8.8 p.c. to 24.3 p.c. which in 5 cases achieved statistical significance.
D000328:Adult; D000368:Aged; D000768:Anesthesia, General; D001537:Bencyclane / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D001794:Blood Pressure / Q000187:drug effects; D002245:Carbon Dioxide / Q000097:blood; D002339:Carotid Arteries / Q000000981:diagnostic imaging; D002560:Cerebrovascular Circulation / Q000187:drug effects*; D002561:Cerebrovascular Disorders / Q000503:physiopathology; D003508:Cycloheptanes / Q000494:pharmacology*; D005260:Female; D006221:Halothane; D006801:Humans; D007275:Injections, Intravenous; D008297:Male; D008657:Metabolic Clearance Rate; D008875:Middle Aged; D009609:Nitrous Oxide; D010313:Partial Pressure; D011859:Radiography; D012039:Regional Blood Flow / Q000187:drug effects*; D014980:Xenon Radioisotopes
D003508:Cycloheptanes; D014980:Xenon Radioisotopes; D002245:Carbon Dioxide; D001537:Bencyclane; D009609:Nitrous Oxide; D006221:Halothane
Das Verhalten der regionalen Gehirndurchblutung unter dem Einfluss von Bencyclan.  Quantitative örtliche Hirndurchblutungsmessungen bei Gesunden und Kranken mit zerebrovaskulärer Insuffizienz im Wachzustand und leichter Allgemeinnarkose