The relationship of the urinary cations, Calcium, Magnesium, Sodium and Potassium, in patients with Renal Calculi.
Calcium, magnesium, sodium and potassium were estimated in the 24-hour urine collections of 101 idiopathic male stone-formers, 89 male patient controls and 59 young male adult controls. The results were calculated in terms of 24-hour volume and 1 g of creatinine. The concentrations of the 4 cations, relative to a gram of creatinine, were also determined in the early-morning urines of 41 male stone-formers and 13 young male adult controls. No difference was observed in the 24-hour excretion of calcium, magnesium and sodium between the stone-formers and controls. The mean daily potassium excretion, however, was significantly reduced in the urine of stone-formers. The linear regression equations were calculated for calcium on magnesium, calcium on sodium, and calcium on potassium, using the 24-hour excretion values of these cations. Only the calcium on potassium line of stone-formers was significantly different from that of the normal subjects. A significant increase by stone-formers in the urinary calcium concentration of their early-morning specimens was found. The high concentration of urinary calcium in overnight urines of stone-formers combined with a low magnesium concentration might possibly contribute to the development of renal stone disease.
D000293:Adolescent; D000328:Adult; D002118:Calcium / Q000652:urine*; D003404:Creatinine / Q000652:urine; D006801:Humans; D007669:Kidney Calculi / Q000652:urine*; D008274:Magnesium / Q000652:urine*; D008297:Male; D008875:Middle Aged; D011188:Potassium / Q000652:urine*; D012964:Sodium / Q000652:urine*; D013997:Time Factors
D012964:Sodium; D003404:Creatinine; D008274:Magnesium; D011188:Potassium; D002118:Calcium