Auditory similarities associated with genetic and experimental acoustic deprivation.
Susceptibility to audiogenic seizures has been produced in otherwise non-susceptible mice by acoustic stress and by conductive hearing loss. Both procedures temporarily elevate the absolute threshold of the auditory evoked potential (AEP) and are maximally effective during a circumscribed period of early development. In the genetically SUSCEPTIBLE DBA/2J mouse, AEP thresholds indicated that its auditory system is functionally less mature during this early period than that of the nonsusceptible C57BL/6Jmouse. It was proposed that innate susceptibility found in the DBA/2J mouse results from auditory disuse supersensitivity during a critical developmental period, in support of Saunders' hypothesis for acoustically primed mice. The increased peak-to-peak AEP amplitudes, however, were not believed to be causally related to the audiogenic seizures.
D000161:Acoustic Stimulation; D000367:Age Factors; D000818:Animals; D001309:Auditory Threshold; D003423:Critical Period, Psychological; D004198:Disease Susceptibility; D004423:Ear / Q000254:growth & development; D005071:Evoked Potentials; D006311:Hearing Disorders / Q000150:complications; D051379:Mice; D008810:Mice, Inbred C57BL; D008811:Mice, Inbred DBA; D013216:Reflex, Startle / Q000502:physiology; D012640:Seizures / Q000209:etiology*; D012683:Sensory Deprivation; D013016:Sound; D013045:Species Specificity