The acute effect of sodium cellulose phosphate on intestinal absorption and urinary excretion of calcium in man.
Intestinal 47Ca absorption has been determined from blood and stool radioactivity after oral administration of the isotope in nine patients before and during cellulose phosphate treatment. Oral administration of 5 g cellulose phosphate concomitant with 47Ca in 100 mg "carrier" calcium as CaCl2 decreased 47Ca absorption by 80 per cent. Cellulose phosphate, 5 g three times daily, decreased urinary excretion of non-radioactive calcium by 47 percent. Urinary magnesium excretion decreased by 47 percent whereas urinary phosphorus excretion increased by 67%. Calcium and magnesium excretion in urine decrease because cellulose phosphate binds divalent cations within the GI tract. The increased phosphorus excretion is probably due to partial hydrolysis of the substance in the gut.
D002118:Calcium / Q000097:blood / Q000378:metabolism / Q000652:urine*; D002482:Cellulose / Q000494:pharmacology* / Q000627:therapeutic use; D003864:Depression, Chemical; D004381:Duodenal Ulcer / Q000188:drug therapy; D006801:Humans; D006961:Hyperparathyroidism / Q000188:drug therapy; D007408:Intestinal Absorption / Q000187:drug effects*; D007674:Kidney Diseases / Q000188:drug therapy; D008274:Magnesium / Q000652:urine; D009943:Organophosphorus Compounds / Q000494:pharmacology* / Q000627:therapeutic use; D011188:Potassium / Q000652:urine; D012507:Sarcoidosis / Q000188:drug therapy; D012964:Sodium / Q000494:pharmacology / Q000627:therapeutic use; D013268:Stimulation, Chemical; D013997:Time Factors
D009943:Organophosphorus Compounds; D002482:Cellulose; D012964:Sodium; D008274:Magnesium; D011188:Potassium; D002118:Calcium