Decreased mitotic activity in the stomach, duodenum and colon of rats treated with high doses of histamine.
Histamine in doses of 25, 50, 100 and 200 mg/kg significantly inhibited mitotic activity of the stomach, duodenum and colon of rats. With the above doses this effect is not dose dependent. However, only the highest dose produced acute gastric mucosal ulceration. It is suggested that decreased mitotic activity is not causally related to ulcer provocation.
D000818:Animals; D003106:Colon / Q000187:drug effects; D003864:Depression, Chemical; D004386:Duodenum / Q000187:drug effects; D005260:Female; D006632:Histamine / Q000008:administration & dosage / Q000494:pharmacology*; D008297:Male; D008938:Mitosis / Q000187:drug effects*; D051381:Rats; D013270:Stomach / Q000187:drug effects; D013276:Stomach Ulcer / Q000139:chemically induced
D006632:Histamine