[Levels of immunoreactive insulin and catecholamines in the blood plasma of patients with congestive heart failure].
The plasma level of the immunoreactive insulin and the blood level of sugar on an empty stomach and following carbohydrate provocation were determined in 31 patients with congestiva heart failure due to ischaemic heart disease. In 26 of them the plasma levels of adrenalin and noradrenalin were also studied. After 30-35 days of active therapy 15 patients were reexamined. The immunoreactive insulin plasma level was determined by the Hales and Randle technique, that of catecholamines-flowmetrically by the trioxyindol method after Vendsalu modified by E. Sh. Matlina. Carbohydrate metabolism disorders that manifested themselve in fasting hyperglycemia and in changing tolerance of glucose were noted in 13 of the 31 patients, examined. In the majority of patients with congestive heart failure insulin secretion was reduced both after fasting and after glucose administration. The improvement of the patients state in response to the employed therapy was accompanied by an increasing insulin secretion. One of the causes of the inhibition of insulin secretion in patients with congestive heart failure consisted in hypercatecholaminemia that was noted in most of the examined cases. The obtained data prove the necessity of a careful control of carbohydrate metabolism in patients with congestive heart failure and of a more active employment of insulin for their treatment.
D000368:Aged; D001786:Blood Glucose; D002395:Catecholamines / Q000097:blood*; D004837:Epinephrine / Q000097:blood; D005215:Fasting; D005260:Female; D005951:Glucose Tolerance Test / Q000379:methods; D006333:Heart Failure / Q000097:blood / Q000276:immunology* / Q000628:therapy; D006801:Humans; D007330:Insulin Antibodies / Q000032:analysis*; D008297:Male; D008875:Middle Aged; D009638:Norepinephrine / Q000097:blood
D001786:Blood Glucose; D002395:Catecholamines; D007330:Insulin Antibodies; D009638:Norepinephrine; D004837:Epinephrine
Soderzhanie immunoreaktivnogo insulina i katekholaminov v plazme krovi u bol'nykh s zastoĭnoĭ serdechnoĭ nedostatochnost'iu