Mechanis of chlorampenicol-cephalordine synergism on Enerobacteiaeae.
A synergistic in vitro bactericidal effect of combinations of chloramphenicol and beta-lactams on strains of Enterobacteriaceae is described. The synergism is seen with strains which are resistant to the beta-lactam and is due to chloramphenicol-induced inhibition of beta-lactamase production.
D002509:Cephaloridine / Q000494:pharmacology*; D002701:Chloramphenicol / Q000494:pharmacology*; D004357:Drug Synergism; D004755:Enterobacteriaceae / Q000187:drug effects*
D002701:Chloramphenicol; D002509:Cephaloridine