Microvascular response to local application of dequalinium chloride. A vital microscopical study of hamster's cheek pouch and a microangiographic study of rabbit's ear.
Dequalinium chloride is a topical antiseptic, whose use may be attended by skin necrosis. Since microcirculatory changes are an early and distinct manifestation of tissue injury, the tissue damaging effect of dequalinium chloride on the microcirculation was examined. The immediate vascular reactions were studied by vital microscopy, of the hamster cheek pouch and the late effects were visualized by microangiography of the rabbit ear. An aqueous solution of dequalinium chloride in concentrations well below those used in clinical practice induced severe microcirculatory disturbances.
D000818:Animals; D002199:Capillary Permeability / Q000187:drug effects; D002610:Cheek / Q000098:blood supply; D006224:Cricetinae; D003864:Depression, Chemical; D003868:Dequalinium / Q000009:adverse effects*; D004305:Dose-Response Relationship, Drug; D004431:Ear, External / Q000098:blood supply; D005260:Female; D006461:Hemolysis; D066298:In Vitro Techniques; D007249:Inflammation / Q000139:chemically induced; D008297:Male; D008833:Microcirculation / Q000187:drug effects*; D011806:Quinolinium Compounds / Q000009:adverse effects*; D011817:Rabbits; D012039:Regional Blood Flow / Q000187:drug effects
D011806:Quinolinium Compounds; D003868:Dequalinium