PGE2:PGE-2:.
The biological activities of 8,12-diiso-PGE2 (ent-11,15-epi-PGE2), PGE2 and PGF2alpha have been compared in a series of pharmacological preparations intended to differentiate between F and E type of activity. Similar to PGF2alpha but unlike PGE2, 8,12-diiso-PGE2 increased the tone of isolated smooth muscle preparations of guinea pig trachea, guinea pig colonic circular layer, rabbit Fallopian tubes. The stimulation effect of 8,12-diiso-PGE2 and PGF2alpha on visceral smooth muscle was also shown in vivo: the two drugs were in all instances able to increase the miogenic activity and tone of rabbit uterus in situ, while these were depressed by PGE2. 8,12-diiso-PGE2 decreased pulmonary compliance and increased pulmonary vascular resistance in the anaesthetized cat; PGE2 always decreased pulmonary vascular resistance, while leaving pulmonary compliance unaltered. The possibility is suggested that 8,12-diiso-PGE2 acts on PGF receptor in different tissues.
D000818:Animals; D002415:Cats; D003106:Colon / Q000187:drug effects; D003864:Depression, Chemical; D005187:Fallopian Tubes / Q000187:drug effects; D005260:Female; D006168:Guinea Pigs; D008168:Lung / Q000098:blood supply; D008170:Lung Compliance / Q000187:drug effects*; D008297:Male; D009129:Muscle Tonus / Q000187:drug effects*; D009130:Muscle, Smooth / Q000187:drug effects; D011453:Prostaglandins / Q000494:pharmacology*; D011817:Rabbits; D013268:Stimulation, Chemical; D014132:Trachea / Q000187:drug effects; D014599:Uterus / Q000187:drug effects; D014655:Vascular Resistance / Q000187:drug effects*
D011453:Prostaglandins