Aflatoxicol H1: a major metabolite of aflatoxin B1 produced by human and rhesus monkey livers in vitro.
Among the major metabolites of aflatoxin B1 produced by human and monkey livers in vitro is a derivative with the ketone carbonyl on the cyclopentane ring reduced to a secondary alcohol, and a hydroxyl introduced onto the carbon beta to the alcohol group. The metabolite was formed from aflatoxin B1 at a level similar to that of aflatoxin M1.Both the microsomal hydroxylase and the cytoplasmic reductase systems are required for its formation. Bioassay using chicken embryos and a mutant of Salmonella typhimurium revealed no toxicity. This newly identified metabolite was named aflatoxicol H1.
D000348:Aflatoxins / Q000032:analysis / Q000378:metabolism / Q000633:toxicity; D000818:Animals; D002474:Cell-Free System; D005260:Female; D006801:Humans; D066298:In Vitro Techniques; D008099:Liver / Q000201:enzymology / Q000378:metabolism*; D008253:Macaca mulatta; D008297:Male; D008875:Middle Aged; D006899:Mixed Function Oxygenases / Q000378:metabolism
D000348:Aflatoxins; D006899:Mixed Function Oxygenases