Nonsteroidal secondary and tertiary amines: inhibitors of insect development and metamorphosis and delta-24-sterol reductase system of tobacco hornworm.
Several new branched and straight chain secondary and tertiary amines were shown to have inhibitive effects upon development and metamorphosis and the delta-24-sterol reductase system in larvae of the tobacco hornworm similar to those previously observed with a number of azasteroids. Certain of the amines which are related structurally to compounds with juvenile hormone activity in insects also blocked development and metamorphosis in three other species of insects. These compounds are lethal or inhibit development in all larval stages and thus differ in action from compounds with juvenile hormone activity where the principal effect is to block the penultimate or ultimate molt.
D000429:Alcohol Oxidoreductases / Q000037:antagonists & inhibitors*; D000577:Amides / Q000138:chemical synthesis / Q000494:pharmacology*; D000818:Animals; D055598:Chemical Phenomena; D002621:Chemistry; D004123:Dimethylamines / Q000494:pharmacology*; D005021:Ethylamines / Q000138:chemical synthesis / Q000494:pharmacology*; D007313:Insecta / Q000187:drug effects / Q000201:enzymology* / Q000254:growth & development; D007814:Larva / Q000187:drug effects / Q000201:enzymology; D008675:Metamorphosis, Biological / Q000187:drug effects*; D008744:Methylamines / Q000138:chemical synthesis; D012855:Sitosterols / Q000494:pharmacology; D013261:Sterols
D000577:Amides; D004123:Dimethylamines; D005021:Ethylamines; D008744:Methylamines; D012855:Sitosterols; D013261:Sterols; D000429:Alcohol Oxidoreductases