[Electrolyte excretion by the rat kidney following intravenous injection of a solution of sodium phosphate].
In rats, after administration of 0.125 ml/100 g sodium phosphate solution (pH 7.4, 0.05 M concentration), the urinary concentration of phosphate was increased just as in control experiments with administration of 0.15 M sodium chloride. The 0.25-0.75M solutions of sodium phosphate led to the maximal urinary phosphate concentration (200-250 mmol/l). Within 120-150 min of the injection the serum phosphate concentration did not differ from the control level. The renal reabsorption of phosphate was decreased in all the experiments. After administration of sodium phosphate, urinary potassium concentration was increased while that of chloride was decreased; no correlation was found between urinary concentration of these ions. The data obtained indicate presence of a specific system of phosphate transport in the cells of the rat kidney.
D000818:Animals; D001692:Biological Transport; D002118:Calcium / Q000652:urine; D002712:Chlorides / Q000652:urine; D004231:Diuresis / Q000187:drug effects; D005260:Female; D007444:Inulin / Q000378:metabolism; D007668:Kidney / Q000378:metabolism*; D009318:Natriuresis / Q000187:drug effects; D010710:Phosphates / Q000494:pharmacology*; D011188:Potassium / Q000652:urine; D051381:Rats; D012964:Sodium / Q000494:pharmacology*; D013431:Sulfates / Q000652:urine; D013997:Time Factors; D014882:Water-Electrolyte Balance / Q000187:drug effects*
D002712:Chlorides; D010710:Phosphates; D013431:Sulfates; D007444:Inulin; D012964:Sodium; D011188:Potassium; D002118:Calcium
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