Chemistry of nonaqueous titration of chlopromazine.
The chemistry of the red color formed during perchloric acid titration of chlorpromazine hydrochloride in acetic acid in the presence of mercuric acetate is discussed. Addition of ascorbic acid prevents the color formation and allows titration using a crystal violet end-point. Ascorbic acid addition also sharpens the potentiometric end-point. Ascrobic acid and its oxidation product, dehydroascorbic acid, being neutral to perchloric acid, do not interfere with the titration.
D001205:Ascorbic Acid / Q000032:analysis; D002746:Chlorpromazine / Q000032:analysis*; D003124:Colorimetry; D004355:Drug Stability; D005609:Free Radicals; D007202:Indicators and Reagents; D007267:Injections; D008722:Methods; D010084:Oxidation-Reduction; D010640:Phenothiazines / Q000032:analysis; D011199:Potentiometry; D012972:Sodium Hydroxide; D013053:Spectrophotometry; D013607:Tablets / Q000032:analysis
D005609:Free Radicals; D007202:Indicators and Reagents; D010640:Phenothiazines; D013607:Tablets; D012972:Sodium Hydroxide; D001205:Ascorbic Acid; D002746:Chlorpromazine