Suppression of antibody synthesis to dinitrophenylated bovine gamma globulin in contact-sensitized guinea pigs.
The anti-DNP response to DNP-BGG is substantially suppressed in guinea pigs sensitized to DNCB. The degree of antibody suppression varies with the mode of skin sensitization and with the degree of conjugation of the challenging immunogen. Suppression of the anti-HSA response was also induced by the prior injection of CFA.
D000818:Animals; D000917:Antibody Formation; D001666:Binding Sites, Antibody; D002417:Cattle / Q000276:immunology; D003429:Cross Reactions; D003877:Dermatitis, Contact; D004137:Dinitrochlorobenzene / Q000276:immunology*; D004140:Dinitrophenols / Q000276:immunology*; D005620:Freund's Adjuvant / Q000276:immunology; D006168:Guinea Pigs; D007104:Immune Adherence Reaction; D007074:Immunoglobulin G; D007165:Immunosuppression Therapy; D008297:Male; D009578:Nitrobenzenes / Q000276:immunology*; D012709:Serum Albumin / Q000276:immunology
D004137:Dinitrochlorobenzene; D004140:Dinitrophenols; D007074:Immunoglobulin G; D009578:Nitrobenzenes; D012709:Serum Albumin; D005620:Freund's Adjuvant