Morphometric studies of the juxtaglomerular apparatus in perimembranous glomerulonephritis.
In 23 cases of perimembranous glomerulonephritis (PGN, membranous nephropathy), the juxtaglomerular cell complex (JGC-complex) in early postmortal (2 cases) and bioptically obtained specimens (21 cases) was investigated quantitatively by planimetry. The results were correlated with the stage of the PGN and the clinical findings. A statistically significant increase in mean size of the JGC-complex was found in perimembranous glomerulonephritis compared with the control group (p smaller than 0.005). Comparing the different morphological stages of PGN, the size of the JGC-complex was increased and the serum creatinine level raised in stages 3 and 4. In hypertensive patients with perimembranous glomerulonephritis, the serum creatinine levels were significantly raised as compared with the normotensive group.
D000293:Adolescent; D000328:Adult; D000368:Aged; D001706:Biopsy; D001794:Blood Pressure; D002462:Cell Membrane; D003404:Creatinine / Q000097:blood; D005260:Female; D005921:Glomerulonephritis / Q000473:pathology*; D006801:Humans; D007606:Juxtaglomerular Apparatus / Q000473:pathology* / Q000648:ultrastructure; D008297:Male; D008875:Middle Aged
D003404:Creatinine