Piperazine derivatives of dimethylxanthines. III. 1-Piperazinoethyltheobromines.
1-Beta-Chloroethyltheobromine (CETb) heated with piperazine in the medium of 2-methoxyethanol yields N,N'-bis-(theobrominyl-1-ethyl)-piperazine dihydrochloride (IIb) or 1-piperazinoethyltheobromine (I). The use of N-methyl, N-beta-hydroxyethyl, N-ethoxycarbonyl and N-phenylpiperazine for exchange of chlorine in CETb lead to corresponding 1-N-alkyl or N-arylpiperazinoethyltheobromines (III--VIa) isolated in the form of salts. The preliminary investigations for diuretic and cardiovascular activity of the obtained compounds were performed.
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D004231:Diuresis / Q000187:drug effects; D007928:Lethal Dose 50; D009043:Motor Activity / Q000187:drug effects; D010879:Piperazines / Q000138:chemical synthesis* / Q000494:pharmacology / Q000633:toxicity; D051381:Rats; D013805:Theobromine / Q000031:analogs & derivatives* / Q000138:chemical synthesis
D010879:Piperazines; D013805:Theobromine