Dynamics of insulin release by perfused hamster )Mesocricetus auratus) pancreases: effects of hypophysectomy, bovine and human growth hormone, and prolactin.
The hamster exhibits a biphasic pattern of insulin secretion; however, the dynamic response differs qualitatively from that of the rat in that there is a steady-state second release phase. A marked attenuation of insulin secretion as a result of hypophysectomy was observed after 3 weeks, but not after 2 weeks. This depression of insulin secretion was restored to near or above normal levels by bovine growth hormone, human growth hormone, and prolactin.
D000818:Animals; D002417:Cattle; D006224:Cricetinae / Q000502:physiology*; D013006:Growth Hormone / Q000502:physiology*; D006801:Humans; D007016:Hypophysectomy; D007328:Insulin / Q000378:metabolism*; D000078790:Insulin Secretion; D008647:Mesocricetus; D010179:Pancreas / Q000187:drug effects / Q000378:metabolism*; D010477:Perfusion; D010902:Pituitary Gland / Q000502:physiology*; D011388:Prolactin / Q000502:physiology*; D013997:Time Factors
D007328:Insulin; D011388:Prolactin; D013006:Growth Hormone