Pentobarbital pharmacokinetics in the normal and in the hepatectomized rat.
The pharmacokinetics of pentobarbital, a barbiturate metabolized by the liver, was compared in normal and in hepatectomized rats. The blood concentration time curve following a single intravenous injection of pentobarbital was fitted to a two-compartment open model. Both the volume of the central compartment and the elimination rate constant were significantly reduced in hepatectomized rats. It is concluded that the liver plays a role both in the metabolism and the distribution of pentobarbital.
D000273:Adipose Tissue / Q000032:analysis; D000818:Animals; D001646:Bile / Q000032:analysis; D001923:Brain Chemistry; D006498:Hepatectomy; D007275:Injections, Intravenous; D007422:Intestines / Q000032:analysis; D007668:Kidney / Q000032:analysis; D007700:Kinetics; D008099:Liver / Q000032:analysis / Q000378:metabolism*; D008168:Lung / Q000032:analysis; D008297:Male; D008954:Models, Biological; D009132:Muscles / Q000032:analysis; D010424:Pentobarbital / Q000032:analysis / Q000097:blood / Q000378:metabolism*; D051381:Rats; D012867:Skin / Q000032:analysis; D013154:Spleen / Q000032:analysis
D010424:Pentobarbital