Synthesis and antimicrobial activity of N-substituted N'-cyano-S-(triorganostannyl)isothioureas.
Six N-substituted N'-cyano-S-(trimethylstannyl)isothioureas were synthesized by the reaction of (trimethylstannyl)cyanamide with various organic isothiocyanates. The IR spectrum of each compound was obtained over the 4000-30-cm(-1) range, and some bands were assigned. The six new compounds and five previously synthesized N-substituted N'-cyano-S-(triphenylstannyl)isothioureas were tested for and were found to exhibit antifungal activity. N-Phenyl-N'-cyano-S-(triphenylstannyl)isothiourea was also investigated for antibacterial activity and was observed to be especially inhibitory toward Gram-positive species. The antimicrobial activity of two compounds was compared to that of the oxygen analogs of these compounds.
D001419:Bacteria / Q000187:drug effects*; D005658:Fungi / Q000187:drug effects*; D009570:Nitriles / Q000138:chemical synthesis / Q000494:pharmacology; D009947:Organotin Compounds / Q000138:chemical synthesis / Q000494:pharmacology; D013890:Thiourea / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000494:pharmacology
D009570:Nitriles; D009947:Organotin Compounds; D013890:Thiourea