Preparation of [18-F]haloperidol.
A procedure is described that permits the preparation of [18F]haloperidol in 140 min at specific activities ranging from 4-5 muCi mg-1. A key step in the synthetic route involves the incorporation of 18F into the molecule through a Schiemann-type reaction, which involves the pyrolysis of the diazonium tetrafluoroborate salt of 4-[4-(p-chlorophenyl)-4-hydroxypiperidino]-4'-aminobutyrophenone.
D005461:Fluorine; D006220:Haloperidol / Q000138:chemical synthesis*; D007553:Isotope Labeling; D008722:Methods; D011868:Radioisotopes
D011868:Radioisotopes; D005461:Fluorine; D006220:Haloperidol