Sythesis of polypeptide models of collagen.
The synthesis of several sequential oligomer models of collagen is reported. Polytripeptides H(-Pro-Gly-Leu)n OH, H(-Pro-Gly-Phe)n OH, H(-Pro-Sar-Gly)n OH, H-(Sar-Pro-Gly-)n -OH, H(-Pro-Gly-V-AL-)N OH and H(-Gly-Val-Pro)n -oh were synthesized by the active ester method. Preliminary fractionation and mol.wt. determination showed typical gaussian distributions. Good yields were obtained in the mol.wt. range of 4,000-6,000, except in the case of H(-Pro-Sar-Gly-)n OH which yielded molecular weights over 20,000.
D005591:Chemical Fractionation; D003094:Collagen / Q000138:chemical synthesis*; D005998:Glycine; D007930:Leucine; D008970:Molecular Weight; D010455:Peptides / Q000138:chemical synthesis*; D010649:Phenylalanine; D011392:Proline; D012521:Sarcosine; D014633:Valine
D010455:Peptides; D010649:Phenylalanine; D003094:Collagen; D011392:Proline; D007930:Leucine; D014633:Valine; D005998:Glycine; D012521:Sarcosine