The duration of tolerance to the anorexigenic effect of amphetamine in rats.
Rats were given dl-amphetamine 16 mg/kg twice daily for 15 days. Complete tolerance to the anorexigenic effect of amphetamine developed from day 7--11. A single injection of 16 mg/kg amphetamine was given to the amphetamine pretreated rats and to saline pretreated controls at different time-points after withdrawal, and their food intakes were compared. Signs of tolerance were present in 16 but not 20 days after withdrawal.
D000661:Amphetamine / Q000008:administration & dosage / Q000494:pharmacology*; D000818:Animals; D001066:Appetite / Q000187:drug effects*; D001835:Body Weight / Q000187:drug effects; D004361:Drug Tolerance; D004435:Eating / Q000187:drug effects; D008297:Male; D051381:Rats; D013997:Time Factors
D000661:Amphetamine