Investigations into the inhibition of DNA repair processes by detergents.
The inhibition of semi-conservative DNA replication and unscheduled DNA synthesis by three different detergents was investigated in mouse spleen cells. The investigations were made by following the kinetics of the incorporation of 3H-thymidine into the DNA, as well as by autoradiographic studies. At various concentrations different inhibition patterns were found and the significance of these findings is discussed.
D000818:Animals; D001345:Autoradiography; D004260:DNA Repair / Q000187:drug effects*; D004261:DNA Replication / Q000187:drug effects; D003864:Depression, Chemical; D003902:Detergents / Q000494:pharmacology*; D004987:Ethers / Q000494:pharmacology; D006918:Hydroxyurea / Q000494:pharmacology; D051379:Mice; D011092:Polyethylene Glycols / Q000494:pharmacology; D011136:Polysorbates / Q000494:pharmacology; D013154:Spleen / Q000166:cytology / Q000378:metabolism; D013936:Thymidine / Q000378:metabolism
D003902:Detergents; D004987:Ethers; D011136:Polysorbates; D011092:Polyethylene Glycols; D013936:Thymidine; D006918:Hydroxyurea