Fat emulsion vehicle for intravenous administration of an aqueous insoluble drug.
Formulation of a sterile preparation for the parenteral administration of a water insoluble drug is described. Methyl CCNU was first dissolved in absolute alcohol and slowly added to a fat emulsion, Intralipid. The preparation was found to be stable for eight hours at room temperature and seven days under refrigeration. After administration of the preparation to approximately 100 patients, no significant side effects were attributed to the fat emulsion.
D004355:Drug Stability; D004655:Emulsions; D000431:Ethanol; D005223:Fats; D007275:Injections, Intravenous; D008130:Lomustine / Q000008:administration & dosage* / Q000009:adverse effects; D009607:Nitrosourea Compounds / Q000008:administration & dosage*; D014677:Pharmaceutical Vehicles; D012995:Solubility
D004655:Emulsions; D005223:Fats; D009607:Nitrosourea Compounds; D014677:Pharmaceutical Vehicles; D000431:Ethanol; D008130:Lomustine