The effect of autonomic and psychotropic drugs on adrenaline reversal in the rat uterus.
Desipramine and other psychotropic and autonomic drugs were tested for their ability to prevent the motor response of the rat uterus to adrenaline in vitro. Those agents which have been shown to prevent catecholamine uptake into stores most readily reversed the motor response; those which had little or no effect on catecholamine storage were usually without effect on the motor response to adrenaline. The motor response of the rat uterus to adrenaline is due to prostaglandin E2. Agents blocking the motor response prevented the release of prostaglandin and did not block the action of prostaglandin on the uterus. Since all the effective agents also interfered with uptake with catecholamine stores it seems likely that passage of catecholamine in and out of storage depots is involved with the synthesis of prostaglandins.
D000818:Animals; D001337:Autonomic Agents / Q000494:pharmacology*; D002395:Catecholamines / Q000378:metabolism; D004837:Epinephrine / Q000037:antagonists & inhibitors*; D004971:Estrus / Q000187:drug effects; D005260:Female; D066298:In Vitro Techniques; D009119:Muscle Contraction / Q000187:drug effects; D011247:Pregnancy; D011458:Prostaglandins E / Q000378:metabolism; D011619:Psychotropic Drugs / Q000494:pharmacology*; D051381:Rats; D013997:Time Factors; D014599:Uterus / Q000187:drug effects* / Q000378:metabolism
D001337:Autonomic Agents; D002395:Catecholamines; D011458:Prostaglandins E; D011619:Psychotropic Drugs; D004837:Epinephrine