Hemoglobin Atlanta or alpha 2 beta 2 75 Leu-Pro (E19): an unstable variant found in several members of a Caucasian family.
Hemoglobin Atlanta, alpha 2 beta 2 75 Leu-Pro (E19), has been found in several members of three generations of a Caucasian family living in metropolitan Atlanta. The abnormal hemoglobin is one of the nine unstable variants in which either a leucyl or an alanyl residue is replaced by a prolyl residue. These substitutions have been observed in the B, E, F, and G helixes of the beta chain and in the H helix of the alpha-chain. Hemoglobin Atlanta heterozygotes are mildly affected by the presence of this unstable hemoglobin.
D000409:Alanine; D000596:Amino Acids / Q000032:analysis; D005260:Female; D005845:Georgia; D006366:Heinz Bodies; D006455:Hemoglobins, Abnormal / Q000032:analysis*; D006801:Humans; D007930:Leucine; D010446:Peptide Fragments / Q000032:analysis; D011392:Proline; D011487:Protein Conformation; D044465:White People
D000596:Amino Acids; D006455:Hemoglobins, Abnormal; D010446:Peptide Fragments; D011392:Proline; D007930:Leucine; D000409:Alanine