Topical application of a chlordane-containing ectoparasiticide: effect on the plasma half-life of warfarin in dogs.
Brief exposure of dogs to topical chlordane solutions resulted in a significant and long-lasting decrease in the biological half-life of orally administered warfarin. The effect is presumed to be an expression of chlordane's well-documented inductive effect on hepatic microsomal drug metabolizing enzymes and its long-term storage in fat depots. The facility with which chlordane is absorbed through the intact skin of dogs may render casually-treated animals unsuitable for subsequent pharmacologic study for long periods of time.
D000284:Administration, Oral; D000287:Administration, Topical; D000818:Animals; D002706:Chlordan / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D004283:Dog Diseases / Q000188:drug therapy; D004285:Dogs / Q000097:blood*; D004478:Ectoparasitic Infestations / Q000188:drug therapy / Q000662:veterinary; D006207:Half-Life; D014859:Warfarin / Q000008:administration & dosage / Q000097:blood*
D002706:Chlordan; D014859:Warfarin