An electrocardiographic pattern of acute myocardial infarction associated with excessive use of aerosolized isoproterenol.
A 39-year-old women inhaled approximately 675 mg of aerosolized isoproterenol in less than three days during an asthmatic attack. Serial enzyme and ECGs were consistent with acute myocardial necrosis. During a three-year-followup period, no clinical evidence or predisposing factors for coronary artery disease were revealed. The close temporal relation of isoproterenol overdosage with mycardial necrosis provides presumptive evidence that the well-documented association of myocardial necrosis with high dosage catecholamines in animals may also occur in man. While in no way detracting from the value of isoproterenol in standard doses, this report alerts physicians to the possibility of another hazard in those who may use this drug to excess.
D000208:Acute Disease; D000328:Adult; D000336:Aerosols; D000818:Animals; D001249:Asthma / Q000188:drug therapy; D004562:Electrocardiography; D005260:Female; D006439:Hemodynamics; D006801:Humans; D007545:Isoproterenol / Q000008:administration & dosage / Q000097:blood / Q000506:poisoning*; D009203:Myocardial Infarction / Q000139:chemically induced*
D000336:Aerosols; D007545:Isoproterenol