Pattern of CSF glucose concentration after induced hyperglycaemia in patients with acute meningitis and evidence of cerebrospinal canal obstruction.
The pattern of glucose CSF concentration after induced hyperglycaemia was studied in 14 patients suffering from acute meningitis and 10 having meningism, as judged by normal CSF. Four out of the first group of patients had symptoms and signs likely to be due to cerebrospinal canal obstruction after the acute phase of the disease was over. When the patterns of CSF glucose concentration of the two groups were compared it was noted that patients suffering from acute meningitis showed generally a quicker and more profound rise of glucose levels after induced hyperglycaemia than patients with meningism. In four cases CSF glucose levels showed a partial or complete failure to rise, despite adequate increase of blood glucose concentration. Subsequent investigation revealed permanent obstruction of the cerebrospinal canal in three of the cases. The usefulness of serial CSF glucose estimations after induced hyperglycaemia as an early screening test for cases with possible obstruction is discussed.
D000208:Acute Disease; D000328:Adult; D001786:Blood Glucose / Q000378:metabolism; D003250:Constriction; D005260:Female; D005947:Glucose / Q000134:cerebrospinal fluid*; D006801:Humans; D006943:Hyperglycemia / Q000134:cerebrospinal fluid / Q000139:chemically induced; D008297:Male; D008581:Meningitis / Q000097:blood / Q000134:cerebrospinal fluid* / Q000150:complications; D008875:Middle Aged; D013116:Spinal Cord; D013118:Spinal Cord Diseases / Q000134:cerebrospinal fluid / Q000209:etiology
D001786:Blood Glucose; D005947:Glucose