Luteolysis induced in pigtail monkeys (Macaca nemestrina) with prostaglandin f 2 alpha, ICI 80996 and ICI 81008.
Non-pregnant pigtail monkeys (M. nemestrina) were given ICI 80996 subcutaneously and ICI 81008 and PGF2alpha subcutaneously or intravaginally, once daily on days 20-30 inclusive, or two or three times on days 24 or 26 only. Doses of 50 mug/kg of ICI 80996, 100 mug/kg of ICI 81008 and approx. 1 mg/kg of PGF2alpha were used. In the majority of monkeys treated subcutaneously a rapid fall in circulating progesterone concentrations and earlier than normal menstrual bleeding occurred. When given per vaginam, ICI 81008 was as effective as when given subcutaneously, though PGF2alpha was less effective intravaginally than by the subcutaneous route.
D000818:Animals; D003338:Corpus Luteum / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D004958:Estradiol / Q000494:pharmacology; D005260:Female; D007275:Injections, Intravenous; D008251:Macaca; D008598:Menstruation / Q000187:drug effects*; D011374:Progesterone / Q000097:blood; D011460:Prostaglandins F / Q000008:administration & dosage / Q000494:pharmacology*; D013268:Stimulation, Chemical
D011460:Prostaglandins F; D011374:Progesterone; D004958:Estradiol