[Effect of somatostatin on betazole-stimulated gastric secretion and carbachol-stimulated pancreatic secretion and gall bladder contraction in man(author's transl)].
The effect of somatostatin on betazole-stimulated gastric secretion and carbachol-stimulated pancreatic secretion and gall bladder contraction has been studied in seven healthy volunteers. Somatostatin (150 and 250 mug/h) inhibited dose-dependently volume of gastric juice and acid output stimulated by 16 mg betazole. Acid concentration was little affected. 500 mug/h were not more effective than 250 mug/h. Pancreatic secretion stimulated by 250 mug carbachol has been reduced by 80-90% and gall bladder contraction abolished by somatostatin infusion (200 mug/h).
D000328:Adult; D001625:Betazole / Q000494:pharmacology*; D002217:Carbachol / Q000494:pharmacology*; D005260:Female; D005704:Gallbladder / Q000187:drug effects*; D005750:Gastric Juice / Q000378:metabolism; D005753:Gastric Mucosa / Q000187:drug effects* / Q000378:metabolism; D006801:Humans; D008297:Male; D009119:Muscle Contraction / Q000187:drug effects; D009130:Muscle, Smooth / Q000187:drug effects; D010179:Pancreas / Q000187:drug effects* / Q000378:metabolism; D011720:Pyrazoles / Q000494:pharmacology*; D013004:Somatostatin / Q000494:pharmacology*
D011720:Pyrazoles; D001625:Betazole; D013004:Somatostatin; D002217:Carbachol
Wirkung von Somatostatin auf die betazol-stimulierte Magensekretion und die carbachol-stimulierte Pankreassekretion und Gallenblasenkontraktion des Menschen