Artificial elimination of drug resistance from group A beta-hemolytic streptococci.
Ten strains of beta-hemolytic streptococci were tested for elimination of resistance to macrolide antibiotics, tetracycline, and chloramphenicol. Six of the strains lost resistance after cultivation at 41 C or addition of acriflavine (0.2 mug/ml). These results suggest that determinants governing resistance to these antibiotics are located on extrachromosomal genetic elements (plasmids) that are widely distributed in streptococci.
D000167:Acriflavine / Q000494:pharmacology; D002701:Chloramphenicol / Q000494:pharmacology; D004352:Drug Resistance, Microbial; D005111:Extrachromosomal Inheritance; D010957:Plasmids; D013291:Streptococcus / Q000187:drug effects*; D013752:Tetracycline / Q000494:pharmacology
D000167:Acriflavine; D002701:Chloramphenicol; D013752:Tetracycline