Laryngeal transplantation: current status 1974.
There are four major areas of concern that must be examined before human laryngeal transplantation can be considered feasible in clinical practice. These are: 1. surgical mechanics of revascularization; 2. reinnervation; 3. prevention of host rejection; and 4. justification. Of these criteria, the first two habe been met sucessfully at present. Safe suppression of rejection without increased risk of cancer recurrence remains to be achieved. Until this third criterion is satisfied, one is probably not justified to make further attempts at laryngeal transplantation in humans.
D000818:Animals; D000961:Antilymphocyte Serum; D001166:Arteriovenous Shunt, Surgical; D001808:Blood Vessels / Q000637:transplantation; D002339:Carotid Arteries / Q000637:transplantation; D004285:Dogs; D006084:Graft Rejection; D006801:Humans; D007165:Immunosuppression Therapy; D007601:Jugular Veins / Q000637:transplantation; D007822:Laryngeal Neoplasms / Q000601:surgery; D007823:Laryngeal Nerves / Q000637:transplantation; D007825:Laryngectomy; D007830:Larynx / Q000098:blood supply / Q000637:transplantation*; D009046:Motor Neurons / Q000637:transplantation; D009364:Neoplasm Recurrence, Local; D009416:Nerve Regeneration; D010791:Phrenic Nerve / Q000637:transplantation; D014184:Transplantation, Homologous; D014630:Vagus Nerve / Q000637:transplantation; D014827:Vocal Cords / Q000294:innervation; D014945:Wound Healing
D000961:Antilymphocyte Serum