[Familial neuroblastoma: cytogenetic investigation of the peripheral blood (author's transl)].
A cytogenetic investigation was performed in a family which included 2 individuals with congenital neuroblastomas of the suprarenal gland confirmed by autopsy and one with a ganglioneuroblastoma of the thoracic wall as well as 3 other individuals with tumors which probably were also neuroblastomas. The lymphocytes of the peripheral blood of 5 healthy relatives as well as of the child with the treated ganglioneuroblastoma failed to show a constant alteration of chromosomes. In this family, therefore, the suggestion could not be proofed that the very rare familial aggregation of neuroblastomas is caused by a hereditary chromosomal aberration.
D000310:Adrenal Gland Neoplasms / Q000235:genetics; D002869:Chromosome Aberrations; D005260:Female; D005729:Ganglioneuroma / Q000235:genetics; D006801:Humans; D007621:Karyotyping; D008214:Lymphocytes / Q000166:cytology; D008297:Male; D009447:Neuroblastoma / Q000235:genetics*; D010375:Pedigree; D013899:Thoracic Neoplasms / Q000235:genetics
Cytogenetische Untersuchung des peripheren Blutes beim familiären Neuroblastom