Unchanged sensitivity to electric shock in L-tryptophan treated rats.
Injections of L-tryptophan (50, 100 and 200 mg/kg) i.p. in rats resulted in dose dependent increases in brain concentrations of tryptophan, 5-hydroxytryptamine and 5-hydroxyindoleacetic acid. Sensitivity to electric shock as measured by flinch and jump thresholds was not changed by L-tryptophan 100 and 200 mg/kg. The results indicate that increased 5-HT turnover does not influence sensitivity to electric shock.
D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects*; D001921:Brain / Q000187:drug effects* / Q000378:metabolism; D004305:Dose-Response Relationship, Drug; D004597:Electroshock; D006897:Hydroxyindoleacetic Acid / Q000378:metabolism; D008297:Male; D009043:Motor Activity / Q000187:drug effects; D051381:Rats; D012701:Serotonin / Q000378:metabolism*; D013268:Stimulation, Chemical; D014364:Tryptophan / Q000008:administration & dosage / Q000494:pharmacology*
D012701:Serotonin; D006897:Hydroxyindoleacetic Acid; D014364:Tryptophan