[Serum concentrations of vitamin A, carotene, retinol-binding protein and prealbumin in patients with cystic fibrosis (author's transl)].
Vitamin A, carotene, retinol-binding protein (RBP), and prealbumin (PA) have been measured in 42 children and adolescents with cystic fibrosis (CF) and in 92 normal controls. All patients with CF were on vitamin A palmitate in twice the dose for normals. For statistical analysis U- test of Wilcoxon, Mann and Whitney, parametric correlation coefficient and Spearman's rank correlation coefficient were used. Compared with those in normal controls mean serum concentrations of vitamin A, carotene and RBP were depressed in patients with CF (P smaller than 0.001), whereas PA levels did not differ significantly from those of normal individuals. In normal controls there was only in serum concentration of PA an elevation with age (r=0.455, P smaller than 0.001). In patients with CF, serum concentration of vitamin A decreased in correlation with age (r=--0.423, P smaller than 0.01). PA and RBP as well as RBP and vitamin A were positively related in both groups (P smaller than 0.001). In normal individuals  there was a highly significant correlation between serum concentrations of vitamin A and carotene (rs=0.606, P smaller than 0.001), whereas in patients with CF this relationship was less significant (rs=0.311, P smaller than 0.02).
D000293:Adolescent; D000328:Adult; D000367:Age Factors; D001798:Blood Proteins / Q000032:analysis*; D002338:Carotenoids / Q000097:blood*; D002648:Child; D002675:Child, Preschool; D003550:Cystic Fibrosis / Q000097:blood* / Q000188:drug therapy; D005260:Female; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D011228:Prealbumin / Q000032:analysis*; D011485:Protein Binding; D012709:Serum Albumin / Q000032:analysis*; D014801:Vitamin A / Q000008:administration & dosage / Q000097:blood* / Q000378:metabolism
D001798:Blood Proteins; D011228:Prealbumin; D012709:Serum Albumin; D014801:Vitamin A; D002338:Carotenoids
Vitamin A, Carotin, retinolbindendes Protein und Präalbumin im Serum von Patienten mit cystischer Fibrose