The primary cultures of animal ascites tumor cells growth in tubes in suspension as a model in the screening of antitumor agents.
By alternating in vivo-in vitro passage of NK/Ly ascitic tumor cells, a line of tumor cells was achieved which can be used for primary in vitro screening of antitumor compounds. Example is given from testing various known and new compounds.
D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology / Q000627:therapeutic use*; D002286:Carcinoma, Ehrlich Tumor / Q000188:drug therapy* / Q000473:pathology; D002478:Cells, Cultured; D003470:Culture Media; D004273:DNA, Neoplasm / Q000378:metabolism; D004353:Drug Evaluation, Preclinical; D066298:In Vitro Techniques; D012334:RNA, Neoplasm / Q000378:metabolism
D000970:Antineoplastic Agents; D003470:Culture Media; D004273:DNA, Neoplasm; D012334:RNA, Neoplasm