Bronchial hypersensitivity to methacholine in monkeys with beta-adrenergic blockade.
In monkeys with beta-adrenergic blockade caused by administration of propranolol, we found that the conductance of the total respiratory system markedly decreased following intravenous administration of methacholine. The presence of beta-adrenergic blockade was judged from inotropic effect on the heart, levels of blood glucose and lactic acid, and the reaction of eosinophils after adrenalin injection.
D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D004342:Drug Hypersensitivity / Q000209:etiology*; D004804:Eosinophils; D004837:Epinephrine / Q000494:pharmacology; D005260:Female; D006339:Heart Rate / Q000187:drug effects; D007773:Lactates / Q000097:blood; D007958:Leukocyte Count; D008251:Macaca / Q000502:physiology*; D008252:Macaca fascicularis / Q000502:physiology*; D008297:Male; D008688:Methacholine Compounds / Q000494:pharmacology; D011433:Propranolol / Q000494:pharmacology*; D012130:Respiratory Hypersensitivity / Q000139:chemically induced*; D012137:Respiratory System / Q000187:drug effects
D001786:Blood Glucose; D007773:Lactates; D008688:Methacholine Compounds; D011433:Propranolol; D004837:Epinephrine