Diuretic agents and glucose reabsorption.
Acetazolamide, chlorothiazide, ethacrynic acid and furosemide were infused to glucose loaded dogs. Glucose reasorption was unchanged after acetazolamide and chlorothiazide. Ethacrynic acid depressed glucose reabsorption significantly. Furosemide caused a modest decrease in glucose reabsorption which was not significant when the control values were compared with the last three experimental values, but which was significant when all experimental values are analyzed. These diuretics most likely depress glucose reabsorption by acting on the proximal tubule, though a distal effect cannot be excluded.
D000042:Absorption; D000086:Acetazolamide / Q000008:administration & dosage / Q000494:pharmacology; D000818:Animals; D001835:Body Weight; D002740:Chlorothiazide / Q000008:administration & dosage / Q000494:pharmacology; D004232:Diuretics / Q000494:pharmacology*; D004285:Dogs; D004976:Ethacrynic Acid / Q000008:administration & dosage / Q000494:pharmacology; D005260:Female; D005665:Furosemide / Q000008:administration & dosage / Q000494:pharmacology; D005919:Glomerular Filtration Rate / Q000187:drug effects; D005947:Glucose / Q000378:metabolism*; D007275:Injections, Intravenous; D007457:Iodine Radioisotopes; D007684:Kidney Tubules / Q000187:drug effects*; D007686:Kidney Tubules, Distal / Q000187:drug effects; D007687:Kidney Tubules, Proximal / Q000187:drug effects; D012964:Sodium / Q000378:metabolism
D004232:Diuretics; D007457:Iodine Radioisotopes; D002740:Chlorothiazide; D005665:Furosemide; D012964:Sodium; D005947:Glucose; D004976:Ethacrynic Acid; D000086:Acetazolamide