Effect of allylisopropylacetamide on Nuclear Ribonucleic Acid synthesis in rat liver.
The porphyrogenic drug allylisopropylacetamide, a potent inducer of delta-aminolaevulinate synthetase, specifically increases nucleoplasmic RNA synthesis in rat liver. The drug-mediated increase in nucleoplasmic RNA synthesis is blocked by cycloheximide and haemin, which also inhibit the enzyme induction.
D000624:5-Aminolevulinate Synthetase / Q000096:biosynthesis; D000081:Acetamides / Q000494:pharmacology*; D000502:Allylisopropylacetamide / Q000494:pharmacology*; D000818:Animals; D002467:Cell Nucleus / Q000378:metabolism; D003513:Cycloheximide / Q000494:pharmacology; D003609:Dactinomycin / Q000494:pharmacology; D004790:Enzyme Induction / Q000187:drug effects; D006427:Hemin / Q000494:pharmacology; D008099:Liver / Q000187:drug effects / Q000378:metabolism* / Q000648:ultrastructure; D012313:RNA / Q000096:biosynthesis*; D051381:Rats; D014529:Uridine
D000081:Acetamides; D003609:Dactinomycin; D000502:Allylisopropylacetamide; D012313:RNA; D006427:Hemin; D003513:Cycloheximide; D000624:5-Aminolevulinate Synthetase; D014529:Uridine