[The contractile capacity of the myocardium, the effect of insulin on it and indices of central hemodynamics in patients with diabetes mellitus].
In comparing the indices in 105 patients with diabetes and in 75 healthy persons a possibility was revealed of significant disturbances of the contractile function of the myocardium also in young patients with diabetes without any clinico-instrumental signs of coronary atherosclerosis.  This proves the significane not only of atherosclerotic changes in the development of myocardial pathology in diabetes, but alos of the metabolic ones.  Against the opinion of some authors, when given in the usual therapeutic doses insulin failed to lead to negative shifts in the phasic structure of the left ventricle systole in diabetics.  For the first time investigations of hemodynamics by the method of diluted Evans blue demonstrated an increase in the plasma volume and of the circulating blood mass, and a decrease of circulation velocity in diabetes.
D000328:Adult; D000367:Age Factors; D001776:Blood Circulation Time; D001810:Blood Volume; D002302:Cardiac Output; D003920:Diabetes Mellitus / Q000188:drug therapy* / Q000503:physiopathology; D006439:Hemodynamics; D006801:Humans; D007328:Insulin / Q000627:therapeutic use*; D009200:Myocardial Contraction; D010953:Plasma Volume; D014655:Vascular Resistance
D007328:Insulin
Sokratitel'naia sposobnost' miokarda, vliianie na nee insulina i pokazateli gemodinamiki u bol'nykh sakharnykh diabetom