Analysis of intellectual and cognitive performance in patients with multi-infarct dementia, vertebrobasilar insufficiency with dementia, and Alzheimer's disease.
A prominent feature in dementia is intellectual deterioration. Review of the clinical literature indicates a lack of suitably quantitated studies of specific intellectual defects in dementia. The present study investigated the performance of patients with multi-infarct dementia (MID), dementia due to Alzheimer's disease (AD), and vertebrobasilar insufficiency (VBI) with dementia using the Wechsler Adult Intelligence Scale (WAIS). Forty-two patients ranging in age from 45 to 85 years (x 66) were included. Significant differences in cognitive and intellectual performance were found between patients with dementia due to VBI and MID versus neuronal atrophy of the Alzheimer's type. The group with AD performed significantly and consistently lower on all measures. There were no significant differences between the two cerebrovascular disease groups, even though the MID group performed consistently more poorly than the VBI group. A discriminant function analysis classified 74% of the patients correctly based on the individual WAIS scores. The diagnosis was more easily made when tasks measuring visual motor coordination and abstract reasoning were included in the analysis.
D000367:Age Factors; D000368:Aged; D000544:Alzheimer Disease / Q000175:diagnosis*; D000704:Analysis of Variance; D001488:Basilar Artery; D002561:Cerebrovascular Disorders / Q000150:complications*; D003071:Cognition; D003704:Dementia / Q000175:diagnosis* / Q000209:etiology; D003937:Diagnosis, Differential; D004522:Educational Status; D005260:Female; D006801:Humans; D007361:Intelligence Tests; D002542:Intracranial Embolism and Thrombosis / Q000150:complications; D008297:Male; D008875:Middle Aged; D019965:Neurocognitive Disorders / Q000175:diagnosis*; D011581:Psychological Tests; D012044:Regression Analysis; D014711:Vertebral Artery