Fetal monkey absorption of 55Fe from amniotic fluid.
A single dose of 0.5 mCi radioiron (55Fe) was injected directly into the amniotic cavity of each of four pregnant monkeys near term. At 6 or 24 hours after 55Fe adminstration, samples of fetal jejunum, ileum, blood, spleen, liver, lung and fetal membranes were taken for radioautography and scintillation counts. Counts were also made on corresponding maternal tissues. Intestinal radioiron levels and localization indicated that fetuses swallowed and absorbed 55Fe within 6 to 24 hours after injection. Silver grains over the meconium bodies of fetal ileum suggested that intestinal epithelium retained at least some of the absorbed radioiron. However, elevated 55Fe levels in fetal blood and hematopoietic organs indicated that transport of radioiron to the circulation had occurred, presumably through fetal intestine, extraembryonic membranes and/or fetal lungs. Transfer of 55Fe across the placenta from fetus to mother occurred at a slow rate, i.e., samples of maternal organs obtained at 24 hours gave low counts.
D000653:Amniotic Fluid / Q000378:metabolism*; D000818:Animals; D001345:Autoradiography; D005260:Female; D005333:Fetus / Q000378:metabolism; D007082:Ileum / Q000378:metabolism; D007267:Injections; D007501:Iron / Q000378:metabolism*; D007504:Iron Radioisotopes; D007583:Jejunum / Q000378:metabolism; D008099:Liver / Q000378:metabolism; D008168:Lung / Q000378:metabolism; D008253:Macaca mulatta; D008431:Maternal-Fetal Exchange; D008470:Meconium / Q000032:analysis; D010920:Placenta / Q000378:metabolism; D011247:Pregnancy
D007504:Iron Radioisotopes; D007501:Iron