[The effect of piromen on the flial-mesenchymal scar in the cortex of hamsters].
In the present work the effect of Piromen is studied on the formation of the glial-mesenchymal scar in the experimentally injuried cortex of hamsters. The uniform effect of the bacterial polysaccharide is suggested in a strong and lasting stimulation of proliferating reactive cells in the traumatic area. The excessive proliferation is combined with a decrease of differentiation in the reactive cells. A reduction of specific activities (phagocytosis, production of collagen and glial filaments) of these cells was also observed. Finally a porous mesenchymal scar develops with a great many of dedifferentiated cells. On the other hand a spongy glial scar is formed, which is due to a desintegration of astrocytic processes in the peritraumatic area. A so far not precisely understood transformation of reactive astrocytes plays an important role herein. The changes of the glial-mesenchymal scar after administration of Piromen, reported in the literature, were on the whole confirmed.
D000818:Animals; D002454:Cell Differentiation; D002455:Cell Division; D002540:Cerebral Cortex / Q000187:drug effects* / Q000293:injuries / Q000473:pathology; D002921:Cicatrix / Q000473:pathology*; D003239:Connective Tissue Cells; D006224:Cricetinae; D008297:Male; D008854:Microscopy, Electron; D009457:Neuroglia / Q000187:drug effects*; D010587:Phagocytosis; D011135:Polysaccharides, Bacterial / Q000494:pharmacology*; D011549:Pseudomonas
D011135:Polysaccharides, Bacterial
Licht-und elektronenmikroskopische Untersuchung der gliös-mesenchymalen Narbe nstruktur in de experimentell traumatisierten Grobetahirnrinde des Goldhamsters nach Anwendung des Bakterienpolysaccharides Piromen