[Autoradiographic study of proline incorporation into cerebral proteins. The influence of learning and of asparaginase administration. (author's transl)].
The distribution of labelled proteins in the brain after the injection of tritiated proline into the third ventricle was studied after autoradiography. In discrete areas, the incorporation proceeds at a faster rate after an avoidance training. The difference between trained and resting animals is much more evident after the injection of 100 units of L-Asparaginase. It is suggested that L-Asparaginase impairs long-term memory through the inhibition of protein synthesis.
D000818:Animals; D001215:Asparaginase / Q000494:pharmacology*; D001345:Autoradiography; D001362:Avoidance Learning; D001921:Brain / Q000378:metabolism*; D008568:Memory / Q000187:drug effects*; D051379:Mice; D008807:Mice, Inbred BALB C; D009419:Nerve Tissue Proteins / Q000096:biosynthesis*; D011392:Proline / Q000378:metabolism*
D009419:Nerve Tissue Proteins; D011392:Proline; D001215:Asparaginase
Etude autoradiographique de l'incorporation de la proline dans les protéines cérébrales. Influence de l'apprentissage et de l'administration d'asparaginase