The anthelmintic efficacy of fenbendazole against a mixed nematode infection in sheep.
Fenbendazole (methyl-5-(phenylthio)-2-benzimidazole carbamate) at dose rates of 5 mg/kg and above was 100 per cent effective in eliminating a naturally acquired Dictyocaulus filaria infection in sheep. The drug was 100 per cent effective in eliminating concurrent infections of adult Trichostrongylus axei, Haemonchus contortus, Haemonchus placei, Ostertagia circumcincta, Ostertagia ostertagii, Cooperia oncophora, Cooperia mcmasterii, Nematodirus spathiger, Neumatodirus filcollis, Oesophagostomum venulosum and Chabertia ovina. Fenbendazole was 93 per cent and 97 per cent effective at doses of 5 and 10 mg/kg respectively in removing infection with adult T colubriformis, and post-treatment worm-egg production was completely suppressed in surviving female worms. No adverse side-effects were observed in treated sheep at either of the two dose rates used.
D000818:Animals; D000871:Anthelmintics / Q000627:therapeutic use*; D001562:Benzimidazoles / Q000627:therapeutic use*; D002219:Carbamates / Q000627:therapeutic use*; D006188:Haemonchiasis / Q000188:drug therapy / Q000662:veterinary; D008297:Male; D009349:Nematode Infections / Q000188:drug therapy / Q000662:veterinary*; D009814:Oesophagostomiasis / Q000188:drug therapy / Q000662:veterinary; D010029:Ostertagiasis / Q000188:drug therapy / Q000662:veterinary; D012756:Sheep; D012757:Sheep Diseases / Q000188:drug therapy*; D013320:Strongyloidea; D014252:Trichostrongyloidiasis / Q000188:drug therapy / Q000662:veterinary; D014253:Trichostrongylosis / Q000188:drug therapy / Q000662:veterinary; D014257:Trichuriasis / Q000188:drug therapy / Q000662:veterinary
D000871:Anthelmintics; D001562:Benzimidazoles; D002219:Carbamates