Bile acid excretion after pull-through operation for Hirschsprung's disease.
Four children with chronic diarrhoea and perianal excoriation after a pull-through operation for Hirschsprung's disease have been shown to have increased but not markedly raised levels of faecal bile acids. Bile acid analysis of the 'bile-rich' duodenal fluid obtained after pancreozymin stimulation in 3 of the patients indicated a marked reduction in the proportion of deoxycholic acid conjugates. These findings are compatible with colonic malabsorption of secondary bile acids in these patients which is related in some way to the pull-through operation, but which is not likely to be the cause of the diarrhoea and the anal excoriation.
D000293:Adolescent; D001647:Bile Acids and Salts / Q000032:analysis / Q000378:metabolism*; D002635:Chenodeoxycholic Acid / Q000032:analysis; D002648:Child; D002675:Child, Preschool; D002793:Cholic Acids / Q000032:analysis; D003840:Deoxycholic Acid / Q000032:analysis; D003967:Diarrhea / Q000209:etiology*; D004386:Duodenum / Q000032:analysis; D005243:Feces / Q000032:analysis*; D005750:Gastric Juice / Q000032:analysis; D005998:Glycine / Q000032:analysis; D006801:Humans; D008055:Lipids / Q000032:analysis; D008531:Megacolon / Q000601:surgery*; D011183:Postoperative Complications; D013654:Taurine / Q000032:analysis
D001647:Bile Acids and Salts; D002793:Cholic Acids; D008055:Lipids; D003840:Deoxycholic Acid; D002635:Chenodeoxycholic Acid; D013654:Taurine; D005998:Glycine