Increased sulfobromophthalein clearance in a patient receiving phenobarbital and other anticonvulsant drugs.
A marked increase in bromosulfophthalein, dibromosulfophthalein, and indocyanine green fractional clearance was found in a patient who had received phenobarbital for 30 years and other anticonvulsant agents for 6 years. This was related to a marked increase in hepatic blood flow, while hepatic extraction remained normal. These changes were associated with signs of hepatic microsomal enzyme induction (in particular a 2-fold increase in liver bilirubin UDP-glucuronyltransferase activity and hypertrophy of the smooth endoplasmic reticulum in the hepatocytes). Drug administration (especially phenobarbital) should be considered as a possible cause of increased bromosulfophthalein clearance in man.
D000328:Adult; D000927:Anticonvulsants / Q000494:pharmacology*; D006801:Humans; D007208:Indocyanine Green / Q000378:metabolism; D008099:Liver / Q000187:drug effects / Q000378:metabolism*; D008297:Male; D010634:Phenobarbital / Q000494:pharmacology*; D013268:Stimulation, Chemical; D013448:Sulfobromophthalein / Q000378:metabolism*
D000927:Anticonvulsants; D013448:Sulfobromophthalein; D007208:Indocyanine Green; D010634:Phenobarbital