Essential fatty acid deficiency: metabolism of 20:3(n-9) and 22:3(n-9) of major phosphoglycerides in subcellular fractions of developing and mature mouse brain.
Essential fatty acid deficiency was initiated in young and mature mice.  The metabolism of 20:3(n-9) and 22:3(n-9) in brain subcellular fractions was followed after the mice were switched from the deficient diet to a corn oil supplemented diet.  After switching to the supplemented diet, the proportions of (n-9) polyunsaturated fatty acids in brain in both groups of mice decreased with time.  The rate of disappearance of (n-9) polyunsaturated fatty acids was faster in the young groups than in the mature group.  In the developing mice, the half-linves of the (n-9) polyunsaturated fatty acids in the total ethanolamine phosphoglycerides of brain microsomal, synaptosomal, and myelin fractions were 3, 10, and 15 days respectively.  In the mature group, the half-lives for 20:3(n-9) in diacyl-glycerophosphorylethanolamine of microsome, synaptosome, and myelin fractions were 8-10, 10, and 22 days, respectively; and the half-lives for 22:3(n-9) in alkenylacyl-glycerophosphorylethanolamine of the same subcellular fractions were 8-12, 28, and rate of disappearance of 20:3(n-9) in brain was faster in the diacyl-glycerophosphorylethanolamine than in the alkenylacyl-glycerophosphorylethanolamine.  These results demonstrate that the metabolism of (n-9) polyunsaturated fatty acid in brain phosphoglycerides during recovery from essential fatty acid deficiency not only varies with age, but also depends upon individual phosphoglycerides present in each subcellular fraction.
D000375:Aging; D000818:Animals; D001835:Body Weight; D001921:Brain / Q000033:anatomy & histology / Q000254:growth & development / Q000378:metabolism*; D004041:Dietary Fats; D005228:Fatty Acids, Essential / Q000172:deficiency / Q000378:metabolism*; D051379:Mice; D008815:Mice, Inbred Strains; D008861:Microsomes / Q000378:metabolism; D009929:Organ Size; D010714:Phosphatidylethanolamines / Q000378:metabolism; D010743:Phospholipids / Q000378:metabolism*; D013347:Subcellular Fractions / Q000378:metabolism; D013574:Synaptosomes / Q000378:metabolism
D004041:Dietary Fats; D005228:Fatty Acids, Essential; D010714:Phosphatidylethanolamines; D010743:Phospholipids