Antitumor action of vitamin A in mice inoculated with adenocarcinoma cells.
Vitamin A palmitate was incorporated into a laboratory chow (150,000 IU/kg diet) and fed ad libitum to C3H/HeJ female mice inoculated with 1 times 10-6 C3HBA tumor cells, beginning the day of inoculation. Control female mice of the same strain similarly inoculated were fed the laboratory chow alone. Vitamin A did not affect rate for the first 19 days, after which growth rates were independent of treatment. Vitamin A-treated mice survived for significantly longer times than did control mice.
D000230:Adenocarcinoma / Q000401:mortality* / Q000473:pathology; D000818:Animals; D004032:Diet; D005260:Female; D008325:Mammary Neoplasms, Experimental / Q000401:mortality* / Q000473:pathology; D051379:Mice; D008809:Mice, Inbred C3H; D014801:Vitamin A / Q000494:pharmacology*
D014801:Vitamin A