Studies in antifertility agents. 8. Seco steroids. 2. 5,6-Secoestradiol and some related compounds.
Three ring beta-secoestradiols, 2alpha,3beta- and 2beta,3beta-2-ethyl-3-(p-hydroxyphenyl)-6beta-methyl-trans-bicyclo[4.3.0]nonan-7beta-ols, have been synthesized and some of them shown to possess significant antiimplantation activity in rats.
D000818:Animals; D002369:Castration; D003281:Contraceptives, Postcoital / Q000138:chemical synthesis*; D003283:Contraceptives, Postcoital, Synthetic / Q000138:chemical synthesis*; D010064:Embryo Implantation / Q000187:drug effects; D004958:Estradiol / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000494:pharmacology; D045166:Estradiol Congeners / Q000138:chemical synthesis; D005260:Female; D009929:Organ Size / Q000187:drug effects; D051381:Rats; D012632:Secosteroids / Q000138:chemical synthesis* / Q000494:pharmacology; D014599:Uterus / Q000187:drug effects; D014621:Vagina / Q000187:drug effects
D003281:Contraceptives, Postcoital; D003283:Contraceptives, Postcoital, Synthetic; D045166:Estradiol Congeners; D012632:Secosteroids; D004958:Estradiol