3-Substituted 2',3'-dihydroestra-1,3,5(10)-trieno (16alpha, 17alpha-b)furan-17beta-ols as potential estrogens.
The preparation, characterization, and estrogenic activity of the two new steroids 3-(cylopentyloxy)-2',3'-dihydroestra-1,3,5(10)-trieno(16alpha,17alpha-b)furan-17beta-ol and 2',3'-dihydroestra-1,3,5(10)-trieno(16alpha,17alphs-b)furan-3,17beta-diol are described. The compounds were found to be 0.1 and 0.002 respectively, as potnet as estrone in a test design to measure the uterine weight gain of treated immature mice relative to controls.
D000818:Animals; D045166:Estradiol Congeners / Q000138:chemical synthesis* / Q000494:pharmacology; D004963:Estrenes / Q000138:chemical synthesis* / Q000494:pharmacology; D005260:Female; D005663:Furans / Q000138:chemical synthesis / Q000494:pharmacology; D009682:Magnetic Resonance Spectroscopy; D051379:Mice; D009929:Organ Size; D014599:Uterus / Q000187:drug effects
D045166:Estradiol Congeners; D004963:Estrenes; D005663:Furans