Short communications. Subunit A from cholera toxin is an activator of adenylate cyclase in pigeon erythrocytes.
Intact cholera toxin and its purified subunit A both activate the adenylate cyclase of pigeon erythrocyte membranes, but subunit B does not. The activation by subunit A is unaffected by treatments that inhibit whole toxin by interfering with the binding of subunit B to cell membranes.
D000262:Adenylyl Cyclases / Q000378:metabolism*; D000818:Animals; D001665:Binding Sites; D002462:Cell Membrane / Q000378:metabolism; D002771:Cholera; D010856:Columbidae; D004789:Enzyme Activation; D004912:Erythrocytes / Q000201:enzymology*; D014118:Toxins, Biological / Q000032:analysis / Q000494:pharmacology*
D014118:Toxins, Biological; D000262:Adenylyl Cyclases