[Investigations on the combined effect of zinc and lead (author's transl)].
The effect of zinc and the combined effect of zinc and lead on the Ala-D of the erythrocytes were experimentally followed in vivo and vitro. It was demonstrated that the zinc effect on the Ala-D is a function of the zinc-concentrate in blood. It was hence traced that ZnCl2 dosis up to 500 mug/ml blood raises the activity of Ala-D. Higher levels of ZnCl2 on other side leads to supression of the Ala-D activity. The experiments demonstrated further zinc exerts a dosis dependent antagonistic effect on the lead suppression of the Ala-D. Possible explanations of the effect of zinc on the Ala-D, and the antagonistic zinc effect after lead applications are still in discussion.
D000818:Animals; D002478:Cells, Cultured; D004912:Erythrocytes / Q000201:enzymology*; D006801:Humans; D006836:Hydro-Lyases / Q000097:blood*; D007275:Injections, Intravenous; D007854:Lead / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D051379:Mice; D000623:Porphobilinogen Synthase / Q000097:blood*; D015032:Zinc / Q000494:pharmacology*
D007854:Lead; D006836:Hydro-Lyases; D000623:Porphobilinogen Synthase; D015032:Zinc
Untersuchungen zur Kombinationswirkung von Zink und Blei