[Description of a case of acute neurological toxicity after DTIC-adriamycin-vincristine therapy (author's transl)].
A case of acute neurological toxicity was observed in a patient with a retroperitoneal fibromyxosarcoma treated with DTIC (NSC-45382), Adriamycin and Vincristine. The neurological symptoms started one hour after drug administration and rapidly declined with symptomatic therapy: no EEG and scintigraphic changes were detectable. The case is discussed in relation to central nervous system complications reported by other authors, following administration of DTIC and Adriamycin.
D001927:Brain Diseases / Q000139:chemically induced*; D003072:Cognition Disorders / Q000139:chemically induced; D003606:Dacarbazine / Q000009:adverse effects* / Q000627:therapeutic use; D004317:Doxorubicin / Q000009:adverse effects* / Q000627:therapeutic use; D004338:Drug Combinations; D005260:Female; D005354:Fibrosarcoma / Q000188:drug therapy*; D006801:Humans; D008875:Middle Aged; D012186:Retroperitoneal Neoplasms / Q000188:drug therapy*; D014226:Triazenes / Q000009:adverse effects*; D014750:Vincristine / Q000009:adverse effects* / Q000627:therapeutic use; D014786:Vision Disorders / Q000139:chemically induced
D004338:Drug Combinations; D014226:Triazenes; D014750:Vincristine; D003606:Dacarbazine; D004317:Doxorubicin
Descrizione di un caso di tossicità neurologica acuta dopo trattamento con adriamicina, vincristina e dimetiltriazenoimidazolcarbossamide (NSC-45388)