A developmental study of girls with trisomy X.
Development of 11 girls (ages 2-10 years) with 47,XXX karyotype identified in a newborn survey is compared with eight girls having a mosaic sex chromatin pattern and with the normal siblings of each group. Delay in early motor development and speech, a mild intellectual deficit, and disturbance in interpersonal relationships occurred in one-third of the index cases, a higher frequency than in the comparison groups. two-thirds were considered normal and adequately adjusted. No consistent phenotype was found.
D000367:Age Factors; D001007:Anxiety; D001290:Attitude; D001722:Birth Order; D002648:Child; D002657:Child Development; D002675:Child, Preschool; D003071:Cognition; D004644:Emotions; D005260:Female; D005817:Genetic Counseling; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007360:Intelligence; D008423:Maternal Age; D008603:Mental Health; D009030:Mosaicism; D009048:Motor Skills; D010287:Parent-Child Relations; D011581:Psychological Tests; D012728:Sex Chromatin; D012730:Sex Chromosomes; D012959:Socioeconomic Factors; D014314:Trisomy