Cytospectrophotometric analysis of DNA content in the invasive cancer of the vervix.
Fourteen cases of invasive, well differentiated squamous cell carcinoma were studied by means of spectrophotometry for relative DNA content in the tumor cells. Comprehensive review of literature on the subject is given. No correlation of relative DNA value in the tumor cells and clinical stage of the malignancy was found. Lack of the correlation between percentage of aneuploid cells and clinical stage of the tumor was observed. Based on the results of this paper and the literature on the subject, the interrelationship of the proportion of aneuploid cells with low arbitrary DNA value and radiosensitivity of the cervical lesion is suggested. The value of quantitative DNA study for treatment planning is emphasized.
D000782:Aneuploidy; D002294:Carcinoma, Squamous Cell / Q000032:analysis / Q000473:pathology / Q000628:therapy; D004273:DNA, Neoplasm / Q000032:analysis*; D005260:Female; D006801:Humans; D013053:Spectrophotometry; D002583:Uterine Cervical Neoplasms / Q000032:analysis / Q000473:pathology* / Q000628:therapy
D004273:DNA, Neoplasm