[Effect of L-thyroxine on the activity and isoenzymatic spectrum of liver hexokinase in intact and insulin-resistant rats].
Administration of L-thyroxine into intact rats caused a distinct increase in the activity of hexokinase in liver tissue. In the isoenzyme spectrum of hexokinase the activity of hexokinase II was increased significantly. After repeated administration of insulin, liver tissue cells lost their capacity to respond to the hormone administration by induction of hexokinase. Administration of L-thyroxine into animals caused a distinct increase in the hexokinase activity in liver tissue. In isoenzyme spectrum of hexokinase under effect of L-thyroxine a significant increase in the hexokinase II activity was also observed.
D000362:Agar; D000818:Animals; D003720:Densitometry; D004586:Electrophoresis; D004789:Enzyme Activation / Q000187:drug effects; D004790:Enzyme Induction / Q000187:drug effects; D006593:Hexokinase / Q000032:analysis / Q000378:metabolism*; D007274:Injections, Intraperitoneal; D007279:Injections, Subcutaneous; D007333:Insulin Resistance; D049528:Insulin, Long-Acting / Q000008:administration & dosage; D007527:Isoenzymes / Q000032:analysis / Q000378:metabolism*; D008099:Liver / Q000201:enzymology*; D008297:Male; D051381:Rats; D013974:Thyroxine / Q000008:administration & dosage / Q000494:pharmacology*; D013997:Time Factors
D049528:Insulin, Long-Acting; D007527:Isoenzymes; D000362:Agar; D006593:Hexokinase; D013974:Thyroxine
Vliianie L-tiroksina na aktivnost' i izofermentnyĭ spektr geksokinazy pecheni intaktnykh i rezistentnykh k insulinu krys