Radiophosphate (32-PO4) incorporation into phosphatidic acid of lead-poisoned and normalred cells.
Radiophosphate incorporation into phosphatidic acid is decreased in the red cells of lead-poisoned humans and rabbits. The decrease in activity is not related to the length of red cell survival nor to the differences in osmotic fragility observed in the lead-poisoned cells. Incorporation of radiophosphate into phosphatidic acid of normal red cells is sulfhydryl dependent and occurs at the cell surface. Lipid composition of the red cell membrane of the lead-poisoned humans and rabbits is normal.
D000085:Acetates / Q000494:pharmacology; D000818:Animals; D001842:Bone and Bones / Q000032:analysis; D002462:Cell Membrane / Q000378:metabolism; D002470:Cell Survival; D004791:Enzyme Inhibitors; D004912:Erythrocytes / Q000032:analysis / Q000378:metabolism*; D005459:Fluorides / Q000494:pharmacology; D006400:Hematocrit; D006801:Humans; D006902:Hydroxymercuribenzoates / Q000494:pharmacology; D007461:Iodoacetates / Q000494:pharmacology; D007854:Lead / Q000032:analysis; D007855:Lead Poisoning / Q000097:blood*; D008628:Mercury / Q000494:pharmacology; D009996:Osmotic Fragility; D010042:Ouabain / Q000494:pharmacology; D010710:Phosphates / Q000378:metabolism*; D010712:Phosphatidic Acids / Q000378:metabolism*; D010743:Phospholipids / Q000378:metabolism*; D010761:Phosphorus Radioisotopes; D011817:Rabbits
D000085:Acetates; D004791:Enzyme Inhibitors; D006902:Hydroxymercuribenzoates; D007461:Iodoacetates; D010710:Phosphates; D010712:Phosphatidic Acids; D010743:Phospholipids; D010761:Phosphorus Radioisotopes; D007854:Lead; D010042:Ouabain; D008628:Mercury; D005459:Fluorides