Biliary lipids during vitamin C feeding in healthy persons.
Inspired by the hypothesis that vitamin C controls the transformation of cholesterol into bile acids, the biliary lipid composition was examined in 10 healthy persons before and after 7 to 15 days' treatment with alrge doses of ascorbic acid. No significant difference between the values before and after treatment were found. It is stressed that the study does not allow evaluation of the hypothesis, but it may be concluded that vitamin C most likely has no place in the medical treatment of cholesterol gallstones.
D001205:Ascorbic Acid / Q000008:administration & dosage / Q000494:pharmacology*; D001646:Bile / Q000187:drug effects / Q000378:metabolism; D001647:Bile Acids and Salts / Q000378:metabolism*; D002784:Cholesterol / Q000097:blood*; D003864:Depression, Chemical; D006801:Humans; D050356:Lipid Metabolism; D010743:Phospholipids / Q000378:metabolism; D013268:Stimulation, Chemical
D001647:Bile Acids and Salts; D010743:Phospholipids; D002784:Cholesterol; D001205:Ascorbic Acid