Delayed lethal response to Candida albicans infection in mice bearing the Lewis lung carcinoma.
Lethality of Candida albicans was monitored in (C57BL times DBA/2)F1 mice bearing the transplanted Lewis lung carcinoma and in sham-operated controls inoculated with Hanks' balanced salt solution. The lethal response to C. albicans infection was significantly delayed in animals inoculated with the microorganism 6-16 days after transplantation of the Lewis lung carcinoma. Maximal increases in survival times were observed when C. albicans was inoculated 8-12 days following tumor transplantation. Therefore, a delay in the lethal response to C. albicans in this untreated model murine tumor system could be elicited through implantation of the Lewis lung carcinoma; preliminary studies with some other model murine tumors and with cell-free filtrates indicated that this phenomenon is not restricted to the Lewis lung carcinoma.
D000818:Animals; D002177:Candidiasis / Q000150:complications* / Q000401:mortality; D008175:Lung Neoplasms / Q000150:complications*; D051379:Mice; D008810:Mice, Inbred C57BL; D008811:Mice, Inbred DBA; D009368:Neoplasm Transplantation; D009374:Neoplasms, Experimental / Q000150:complications; D014184:Transplantation, Homologous