Isolated marrow reticuloendothelial activation and erythropoietic response following an acute blood loss.
The radioassay technique with the 113mIndium-iron chondroitin sulfate colloid, developed in our laboratory, revealed that an isolated marrow reticuloendothelial activation takes place after bleeding 15 to 30 ml of blood per kg body weight from a rabbit. It parallels the erythropoietic response very well. The present stimulation method might deserve testing for studies where marrow reticuloendothelial function is important such as in cancer-bearing patients, the effects of anticancer chemotherapy and gross antigenization.
D000208:Acute Disease; D000740:Anemia / Q000097:blood / Q000378:metabolism / Q000503:physiopathology*; D000818:Animals; D001815:Bloodletting; D001853:Bone Marrow / Q000378:metabolism / Q000503:physiopathology*; D002807:Chondroitin / Q000378:metabolism; D003102:Colloids; D004195:Disease Models, Animal; D004920:Erythropoiesis; D005260:Female; D007065:Idoxuridine / Q000378:metabolism; D007204:Indium / Q000378:metabolism; D007501:Iron / Q000097:blood; D008099:Liver / Q000378:metabolism; D008297:Male; D008722:Methods; D012157:Mononuclear Phagocyte System / Q000503:physiopathology*; D011817:Rabbits; D011868:Radioisotopes; D013154:Spleen / Q000378:metabolism
D003102:Colloids; D011868:Radioisotopes; D007204:Indium; D002807:Chondroitin; D007501:Iron; D007065:Idoxuridine