Ellipticine derivatives.
Several acyloxy and alkyl derivatives of ellipticine have been prepared.  In addition, a modified synthesis leading to the hitherto unobtainable 8,9-dimethoxy- and 8,9-methylenedioxyellipticines is described.  Some of the derivatives described herein exhibit antitumor activity.  However, none of the compounds showed activity superior to that of the naturally occurring pyridocarbazoles, ellipticine and 9-methoxyellipticine.
D000470:Alkaloids / Q000138:chemical synthesis*; D000818:Animals; D002286:Carcinoma, Ehrlich Tumor / Q000188:drug therapy; D004611:Ellipticines / Q000138:chemical synthesis* / Q000627:therapeutic use; D051379:Mice; D012510:Sarcoma 180 / Q000188:drug therapy
D000470:Alkaloids; D004611:Ellipticines