Ankylosing spondylitis in a large kindred: clinical and genetic studies.
In a kindred of 66 members spanning four generations, seven cases of ankylosing spondylitis (AS) HAVE BEEN FOUND. Four of these were in a single sibship of 13. AS was associated with HL-A27 in three of the four involved siblings, but close linkage was shown to be unlikely. Knowledge of HL-A genotype has made possible informed counseling for younger members of the sibship of 13, some of whom, as teenagers, already have back pain.
D000293:Adolescent; D000328:Adult; D001789:Blood Group Antigens; D003376:Counseling; D005260:Female; D008040:Genetic Linkage; D006649:Histocompatibility Antigens / Q000032:analysis*; D006801:Humans; D008297:Male; D008875:Middle Aged; D012703:Serotyping; D013167:Spondylitis, Ankylosing / Q000235:genetics*
D001789:Blood Group Antigens; D006649:Histocompatibility Antigens