Laxative-induced hypokalemia, sodium depletion and hyperreninemia. Effects of potassium and sodium replacement on the renin-angiotensin-aldosterone system.
A patients with marked chronic hypokalemia (potassium, 1.7 to 2;3 meg/litre) and sodium depletion secondary to lazative abuse and dietary inadequacy was studied with respect to the renin-aldosterone system during sequential potassium and potassium-plus-sodium replacement. Extreme hyperreninemia of 20 Goldblatt units X 10-minus 4 was reduced to 0.9 with potassium replacement alone. Aldosteron excretion (15.8 mug/24 h) was initially low for a sodium-deprived state and high for a potassium-deprived state; it increased with potassium administration, but this rise was opposed by decreases in renin secretion induced by potassium and sodium administration. The results provide clinical confirmation of a dual effect of potassium on aldosterone secretion, with renin as a mediator.
D000450:Aldosterone / Q000378:metabolism* / Q000652:urine; D000804:Angiotensin II / Q000378:metabolism*; D000808:Angiotensinogen / Q000097:blood; D002400:Cathartics / Q000506:poisoning*; D004305:Dose-Response Relationship, Drug; D005260:Female; D006801:Humans; D007008:Hypokalemia / Q000139:chemically induced* / Q000378:metabolism; D008875:Middle Aged; D011188:Potassium / Q000378:metabolism* / Q000494:pharmacology; D011863:Radioimmunoassay; D012083:Renin / Q000097:blood* / Q000378:metabolism; D012964:Sodium / Q000172:deficiency / Q000378:metabolism* / Q000494:pharmacology; D019966:Substance-Related Disorders; D014882:Water-Electrolyte Balance / Q000187:drug effects
D002400:Cathartics; D000808:Angiotensinogen; D000804:Angiotensin II; D000450:Aldosterone; D012964:Sodium; D012083:Renin; D011188:Potassium