[Lupus nephropathy. Treatment with the indomethacin-hydroxychloroquine combination and comparison with corticoids].
The authors report their comparative experience of the treatment of proliferative lupus glomerulonephritis using prednisone (16 patients) or the indomethacin-hydroxychloroquine association (12 patients). Prednisone in high dosage was associated in this series with 9 deaths and in 6 patients, with renal failure or an extra-renal complication. By contrast, the indomethacin-hydroxychloroquine association proved to be highly effective, without side-effect. In the endocapillary glomerulonephritis group (8 cases) the authors obtained 7 durable remissions (36.3 months on average) and 1 temporary remission of 24 months, with an average length of treatment of 45.8 months. In the extracapillary glomerulonephritis group (4 cases) the authors obtained 1 remission, 2 improvements and I death, with an average length of treatment of 16.8 months. This combination has a highly significant anti-proteinuric and anti-haematuric action, with a constant efficiency on renal function and on the extra-renal signs of lupus. Its effect is less constant on the immunological disorders. Study of iterative renal biopsies confirms this favourable impression. According to these results, the authors propose a provisional scheme of management of proliferative lupus glomerulonephritis.
D000293:Adolescent; D000328:Adult; D000906:Antibodies / Q000032:analysis; D003165:Complement System Proteins / Q000032:analysis; D004357:Drug Synergism; D004359:Drug Therapy, Combination; D005260:Female; D005921:Glomerulonephritis / Q000188:drug therapy* / Q000209:etiology / Q000276:immunology / Q000473:pathology; D006801:Humans; D006886:Hydroxychloroquine / Q000627:therapeutic use*; D007213:Indomethacin / Q000627:therapeutic use*; D007231:Infant, Newborn; D007668:Kidney / Q000473:pathology; D007677:Kidney Function Tests; D008180:Lupus Erythematosus, Systemic / Q000150:complications / Q000188:drug therapy* / Q000276:immunology / Q000473:pathology; D008297:Male; D008854:Microscopy, Electron; D008875:Middle Aged; D011241:Prednisone / Q000627:therapeutic use*
D000906:Antibodies; D006886:Hydroxychloroquine; D003165:Complement System Proteins; D011241:Prednisone; D007213:Indomethacin
La néphropathie lupique Traitement par l'association indométacine-hydroxychloroquine et comparaison avec les corticoïdes