Pressure-flow relationships in the peripheral circulation of the dog with isoprenaline.
1. The effects of isoprenaline on the pressure-flow relationships in the peripheral circulation were studied in five anaesthetized dogs during right heart bypass procedures. 2. Isoprenaline (1 mug/kg per min) produced a significant drop in arterial pressure and arterial resistance. 3. There was a significant decrease in the resistance to venous return which resulted in a significant increase in venous return. 4. The findings suggest that the increase in cardiac output produced by isoprenaline results in large part from dilatation of venous resistance vessels.
D000818:Animals; D001775:Blood Circulation / Q000187:drug effects*; D001794:Blood Pressure / Q000187:drug effects*; D002302:Cardiac Output / Q000187:drug effects; D003864:Depression, Chemical; D004285:Dogs; D007545:Isoproterenol / Q000494:pharmacology*; D014655:Vascular Resistance / Q000187:drug effects
D007545:Isoproterenol