Dieldrin toxicity and in vivo incorporation of DL-(1-14 C)leucine.
The in vivo effect of a single oral dose (30mg/kg body weight) of dieldrin on proteolipid and phosphatidopeptide content of liver and brain and on total protein of liver, brain, plasma, muscle and kidney of rat was studied. Incorporation of (14C)leucine into total protein of liver was increased whereas labelling of total protein of muscle was decreased. Labelling of total protein of other tissues was unchanged. Incorporation into liver phosphatidopeptides was increased and this was consistent with an involvement of group. Proteolipid protein content of brain was increased and that of liver unchanged. There was, however, no change in the labelling of brain or liver proteolipids.
D000818:Animals; D001835:Body Weight / Q000187:drug effects; D001923:Brain Chemistry / Q000187:drug effects; D004026:Dieldrin / Q000494:pharmacology*; D007668:Kidney / Q000378:metabolism; D007930:Leucine / Q000378:metabolism*; D008074:Lipoproteins / Q000378:metabolism; D008099:Liver / Q000378:metabolism; D008297:Male; D009132:Muscles / Q000378:metabolism; D009929:Organ Size / Q000187:drug effects; D010748:Phosphopeptides / Q000378:metabolism; D011506:Proteins / Q000378:metabolism; D051381:Rats
D008074:Lipoproteins; D010748:Phosphopeptides; D011506:Proteins; D007930:Leucine; D004026:Dieldrin