Analysis of changes in reactivity of rabbit arteries and veins two weeks after induction of hypertension by coarctation of the abdominal aorta.
Vessel dimensions and characteristic responses to norepinephrine were measured in various arteries and veins of the rabbit made hypertensive by partial constriction of the upper abdominal aorta. The ear, radial, and basilar arteries taken from the circulation proximal to the ligature (the hypertensive arteries) were thickened in proportion to the rise is arterial blood pressure. The water, sodium, and potassium contents of these and all other vessels were not significantly changed in the hypertensive rabbits. The maximum response to norepinephrine in the ear artery, a representative vessel from the hypertensive part of the rabbit, was increased, whhereas the sensitivity of this vessel to norepinephrine expressed as the ED50 did not alter with changes in the arterial blood pressure. In contrast, the thickness and the maximum response to norepinephrine of the saphenous artery, representative of vessels distal to the ligature (normotensive vessels) and of the saphenous and cephalic veins were unaltered. The sensitivity as indicated by the norepinephrine ED50 of the veins, but not of the saphenous artery, increased with a rise in carotid artery blood pressure. These results suggest that the increased responsiveness to norepinephrine of arteries proximal to the ligature is due to changes in muscle mass and that the increased responsiveness of the veins is due to increased sensitivity to norepinephrine.
D000818:Animals; D001012:Aorta, Abdominal; D001017:Aortic Coarctation / Q000150:complications / Q000503:physiopathology*; D001808:Blood Vessels / Q000503:physiopathology*; D004195:Disease Models, Animal; D005260:Female; D006973:Hypertension / Q000209:etiology / Q000503:physiopathology*; D008297:Male; D009119:Muscle Contraction; D009638:Norepinephrine / Q000494:pharmacology; D011817:Rabbits; D013997:Time Factors; D014655:Vascular Resistance / Q000187:drug effects; D014666:Vasomotor System / Q000187:drug effects / Q000378:metabolism / Q000503:physiopathology; D014882:Water-Electrolyte Balance
D009638:Norepinephrine