[Metabolic stress by guanosin in healthy persons and in patients suffering from gouty arthritis].
The oral administration of 2 g guanosine resulted in both normal and gouty patients in a significant increase of serum uric acid levels, remaining for 24 hours above the initial values. There was no difference in the response of both groups investigated, indicating that a "purine-tolerance test" has no significance in the diagnosis of arthritis urica. The 24-hour-rhythm of serum aicd was studied in 20 normal persons, showing no statistical significant differences. The results of this investigation demonstrate that blood-sampling for uric acid determination can be performed at any time of the day, provided a provided a purine-poor diet is given 24 hours before.
D000284:Administration, Oral; D001806:Blood Urea Nitrogen; D002940:Circadian Rhythm; D003404:Creatinine / Q000097:blood; D006073:Gout / Q000097:blood / Q000175:diagnosis / Q000378:metabolism*; D006151:Guanosine / Q000008:administration & dosage; D006801:Humans; D008657:Metabolic Clearance Rate; D014527:Uric Acid / Q000097:blood / Q000652:urine
D006151:Guanosine; D014527:Uric Acid; D003404:Creatinine
Stoffwechselbelastung mit Guanosin bei Gesunden und bei Patienten mit Arthritis Urica