Phenobarbital protection against methyl mercury neophrotoxicity.
Phenobarbital injections to rats given a low oral dose level of methl mercury for 2 or 4 wk decreased methyl mercury-induced ultrastructural alterations in kidney proximal tubule cells, increased urinaryexcretion of inorganic mercury and increased blood concentrations of methylmercury. These effects were not seen after 2 wk of treatment but were highly significant after 4 wk.
D000818:Animals; D004721:Endoplasmic Reticulum / Q000187:drug effects / Q000648:ultrastructure; D007274:Injections, Intraperitoneal; D007687:Kidney Tubules, Proximal / Q000187:drug effects* / Q000473:pathology; D008297:Male; D008628:Mercury / Q000032:analysis / Q000097:blood / Q000652:urine; D008767:Methylmercury Compounds / Q000097:blood / Q000633:toxicity* / Q000652:urine; D008854:Microscopy, Electron; D010634:Phenobarbital / Q000008:administration & dosage / Q000494:pharmacology*; D051381:Rats; D013997:Time Factors
D008767:Methylmercury Compounds; D008628:Mercury; D010634:Phenobarbital