Immunohistology of the antigenic pattern of a continuous cell line from a human colon tumor.
The antigenic surface pattern of a continuous cell line (HT29) derived from a human primary carcinoma of the colon was studied by the immunofluorescence technique. Monovalent and polyvalent immune sera were used. The cells of this long-term culture kept the ability to synthesize the three principal colon tumor antigens: carcinoembryonic and nonspecific cross-reacting antigens, and the membrane-associated tissular autoantigen. On the HT29 cells, which still carry the original blood group of the tumor donor, no receptors for human Ig's were detected.
D000951:Antigens, Neoplasm; D001666:Binding Sites, Antibody; D001789:Blood Group Antigens; D002272:Carcinoembryonic Antigen; D002460:Cell Line; D003110:Colonic Neoplasms / Q000276:immunology*; D003429:Cross Reactions; D007141:Immunoglobulin Fc Fragments; D007074:Immunoglobulin G
D000951:Antigens, Neoplasm; D001789:Blood Group Antigens; D002272:Carcinoembryonic Antigen; D007141:Immunoglobulin Fc Fragments; D007074:Immunoglobulin G