[Plasma-androgens following oral administration of testosterone. Influence of sex, age, and liver function (author's transl)].
The influence of sex, age, and liver function on the androgenmetabolizing capacity of the liver was investigated. To that end, testosterone was administered orally to healthy men, women and prepubertal boys as well as to men with liver dysfunction. While normal men (n = 17) and men with fatty liver (n = 9) showed no rise in circulating plasma testosterone levels and only a slight increase in androstenedione, a steep increase in both steroids was observed in men with liver cirrhosis (n = 7). Unlike adult men, boys (n = 7) and women (n = 6) also showed elevated testosterone levels after oral administration of this steroid. It is concluded that the hepatic capacity to metabolize testosterone is influenced by sex, stage of development, and liver function. It seems possible that peripheral concentration of testosterone after its oral administration can serve as a clinical test for liver function.
D000284:Administration, Oral; D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000368:Aged; D000735:Androstenedione / Q000097:blood; D002648:Child; D005234:Fatty Liver / Q000378:metabolism; D005260:Female; D006801:Humans; D008099:Liver / Q000378:metabolism; D008103:Liver Cirrhosis / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D011627:Puberty; D012737:Sex Factors; D013739:Testosterone / Q000097:blood / Q000378:metabolism*
D013739:Testosterone; D000735:Androstenedione
Androgene im Plasma nach oraler Verabreichung von Testosteron. Einfluss von Alter,  Geschlecht und Leberfunktion