A central nervous system depressant-antidepressant.
A new tricyclic agent with an allenyl side chain experimentally shows antidepressant activity similar to amitriptyline and imipramine but also exerts marked CNS depression. Such dual activity should be of clinical interest for treatment of mixed anxiety and depression.
D000466:Alkadienes / Q000494:pharmacology; D000818:Animals; D000929:Antidepressive Agents, Tricyclic; D001522:Behavior, Animal / Q000187:drug effects; D001831:Body Temperature / Q000187:drug effects; D003986:Dibenzocycloheptenes / Q000494:pharmacology* / Q000633:toxicity; D051379:Mice; D012110:Reserpine / Q000037:antagonists & inhibitors
D000466:Alkadienes; D000929:Antidepressive Agents, Tricyclic; D003986:Dibenzocycloheptenes; D012110:Reserpine