Catecholamine release as mediator of intracellular enzyme activation in ischaemic perfused rat hearts.
Isolated rat hearts perfused at suboptimal pressures have been studied as a model for generalised myocardial ischaemia. Glycogen phosphorylase a and hormone-sensitive triglyceridase activities, measured as markers for endogenous catecholamine release, were significantly increased at low perfusion pressures. Pharmacological blockage of noradrenaline re-uptake accentuated these effects, and depletion of catecholamine reserves eliminated them. This phenomenon may be important in the pathophysiology of cardiac ischaemia and its serious complications.
D000818:Animals; D002395:Catecholamines / Q000378:metabolism*; D003124:Colorimetry; D003327:Coronary Disease / Q000201:enzymology / Q000378:metabolism*; D003593:Cytoplasm / Q000201:enzymology; D003864:Depression, Chemical; D004195:Disease Models, Animal / Q000201:enzymology / Q000378:metabolism; D004789:Enzyme Activation; D005260:Female; D066298:In Vitro Techniques; D008049:Lipase / Q000378:metabolism*; D008297:Male; D008928:Mitochondria / Q000201:enzymology; D009206:Myocardium / Q000201:enzymology / Q000378:metabolism*; D010477:Perfusion; D010643:Phenoxybenzamine / Q000494:pharmacology; D006005:Phosphorylases / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains; D012110:Reserpine / Q000494:pharmacology; D014280:Triglycerides
D002395:Catecholamines; D014280:Triglycerides; D010643:Phenoxybenzamine; D012110:Reserpine; D006005:Phosphorylases; D008049:Lipase