Antiinflammatory activity of alpha-methyl-3-phenyl-7-benzofuranacetic acid (R-803).
The antiinflammatory activity of R-803 (alpha-methyl-3-phenyl-7-benzofuranacetic acid), a new nonsteroidal drug, has been demonstrated. The oral administration of R-803 inhibits carrageenan-induced edema of the rat's paw, ultraviolet-induced erythema of guinea-pig skin, adjuvant-induced and 6-sulfonamidoindazole-induced arthritides of the rat at doses in the range of 1.0 to 6.0 mg/kg. It also inhibits the cotton pellet-induced granuloma in the rat at higher doses.
D000818:Animals; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use*; D001168:Arthritis / Q000188:drug therapy; D001572:Benzofurans / Q000627:therapeutic use*; D004487:Edema / Q000188:drug therapy; D004890:Erythema / Q000188:drug therapy; D005260:Female; D006099:Granuloma / Q000188:drug therapy; D006168:Guinea Pigs; D008297:Male; D011833:Radiation Injuries, Experimental / Q000188:drug therapy; D051381:Rats; D014466:Ultraviolet Rays
D000893:Anti-Inflammatory Agents; D001572:Benzofurans; C010258:enprofen