Effect of protein hormones and steroids on tissue cultures of endometrial carcinoma.
Neoplastic tissue was obtained from 30 patients with endometrial carcinoma and the response of this tissue to various hormones was studied in vitro by histological methods and by measuring the incorporation of 3-H thymidine into DNA. Progesterone and synthetic progestogens had a consistently adverse effect on tissue survival in vitro while pregneolone  had a beneficial effect.
D001345:Autoradiography; D002470:Cell Survival / Q000187:drug effects; D046508:Culture Techniques; D004247:DNA / Q000096:biosynthesis; D004717:Endometrium / Q000187:drug effects; D004958:Estradiol / Q000494:pharmacology*; D004964:Estriol / Q000494:pharmacology; D005032:Ethylestrenol / Q000494:pharmacology; D005260:Female; D006801:Humans; D006908:Hydroxyprogesterones / Q000031:analogs & derivatives / Q000494:pharmacology; D008525:Medroxyprogesterone / Q000627:therapeutic use; D011284:Pregnenolone / Q000494:pharmacology*; D011374:Progesterone / Q000494:pharmacology*; D045167:Progesterone Congeners / Q000494:pharmacology*; D013936:Thymidine / Q000378:metabolism; D014594:Uterine Neoplasms / Q000378:metabolism / Q000473:pathology* / Q000532:radiotherapy
D006908:Hydroxyprogesterones; D045167:Progesterone Congeners; D011374:Progesterone; D004958:Estradiol; D011284:Pregnenolone; D004247:DNA; D005032:Ethylestrenol; D004964:Estriol; D008525:Medroxyprogesterone; D013936:Thymidine