Antiallergic activity of omega-nitroacetophenones.
Selected omega-nitroacetophenones, formed by the alcoholic cleavage of 2-nitroindandiones, have been shown to inhibit the homocytotropic antibody-antigen induced passive cutaneous analhylaxis reaction in the rat.  The enzymatic cyclization of these derivatives to the parent nitroindandione has been demonstrated both in vivo and in vitro and this process is suggested as a possible prerequisite to biological activity.
D000098:Acetophenones / Q000097:blood / Q000138:chemical synthesis* / Q000627:therapeutic use; D000818:Animals; D003500:Cyclization; D006967:Hypersensitivity / Q000188:drug therapy*; D066298:In Vitro Techniques; D008099:Liver / Q000378:metabolism; D009574:Nitro Compounds / Q000097:blood / Q000138:chemical synthesis / Q000627:therapeutic use; D010323:Passive Cutaneous Anaphylaxis; D051381:Rats; D013056:Spectrophotometry, Ultraviolet
D000098:Acetophenones; D009574:Nitro Compounds