Cyanogen condensations as a route to 3-amino-2-imino-1,3-benzothiazin-4-ones with CNS depressant potential.
Seven new 3-amino-2-imino-1,3-benzothiazin-4-ones, prepared from the condensation of cyanogen and 2-mercaptobenzhydrazides, were evaluated in a neuropharmacological mouse profile. CNS depression was observed in several members of the class.
D000818:Animals; D002490:Central Nervous System / Q000187:drug effects*; D003488:Cyanogen Bromide; D003864:Depression, Chemical; D007928:Lethal Dose 50; D051379:Mice; D013843:Thiazines / Q000138:chemical synthesis* / Q000494:pharmacology / Q000633:toxicity
D013843:Thiazines; D003488:Cyanogen Bromide