Sensitive method for the routine determination tricyclic antidepressants in plasma using a specific nitrogen detector.
The sensitivity of the alkali flame ionization detector to the tricyclic antidepressant drugs has been studied and limits of detection measured. A backflush system has been used to enable measurement in plasma extracts. A general method for the estimation of tricyclic plasma levels has been developed and exemplified by the measurement of imipramine at therapeutic levels.
D000929:Antidepressive Agents, Tricyclic / Q000097:blood*; D002849:Chromatography, Gas / Q000379:methods; D004305:Dose-Response Relationship, Drug; D004355:Drug Stability; D006801:Humans; D007099:Imipramine / Q000097:blood; D008722:Methods; D009584:Nitrogen
D000929:Antidepressive Agents, Tricyclic; D009584:Nitrogen; D007099:Imipramine