Uptake of 3H-uridine into brain and incorporation into brain RNA of rats exposed to various training tasks - a biochemical analysis.
Operant schedules were used to isolate component parts of a training task and rates of incorporation of 3H-uridine into the brain and brain RNA were determined. Rats that developed a discrimination in responding to a visual stimulus absorbed more radioactivity into the brain and incorporated a higher percentage of this radioactivity into total and cytoplasmic RNA than littermates exposed to the visual stimulus only. Of the component parts of the training task, the discrimination accounted for the greatest increase in absorption of radioactivity and incorporation of it into RNA. The schedule change had the second largest effect and the stimulus change the least.
D000818:Animals; D001921:Brain / Q000378:metabolism* / Q000648:ultrastructure; D001923:Brain Chemistry; D002467:Cell Nucleus / Q000378:metabolism; D003593:Cytoplasm / Q000378:metabolism; D005108:Extinction, Psychological; D007858:Learning / Q000502:physiology*; D008297:Male; D012313:RNA / Q000096:biosynthesis*; D051381:Rats; D011919:Rats, Inbred Strains; D012055:Reinforcement Schedule; D014529:Uridine / Q000378:metabolism*
D012313:RNA; D014529:Uridine