Globin synthesis in subjects doubly heterozygous for hemoglobin G-Philadelphia and hemoglobin S or C.
To study the function of globin-chain genes, in vitro synthesis of globin was measured in reticulocytes concentrated from the peripheral blood of 7 subjects doubly heterozygous for an alpha-chain abnormality (Hb G-Philadelphia) and a beta-chain abnormality (Hb S or C). Each had a deficit of alpha-chain synthesis compatible with an alpha-thalassemia-like syndrome. The data are also compatible with the quantitative expression of variable reduplication of the alpha-chain locus in man.
D001741:Black or African American; D000483:Alleles; D000740:Anemia / Q000097:blood; D002250:Carbon Radioisotopes; D004913:Erythrocytes, Abnormal / Q000032:analysis; D005260:Female; D005914:Globins / Q000096:biosynthesis*; D006400:Hematocrit; D006444:Hemoglobin C / Q000032:analysis; D006451:Hemoglobin, Sickle / Q000032:analysis; D006453:Hemoglobinopathies / Q000235:genetics*; D006454:Hemoglobins / Q000032:analysis; D006455:Hemoglobins, Abnormal / Q000378:metabolism*; D006579:Heterozygote; D006801:Humans; D066298:In Vitro Techniques; D008297:Male; D008875:Middle Aged; D012156:Reticulocytes / Q000032:analysis; D014481:United States
D002250:Carbon Radioisotopes; D006451:Hemoglobin, Sickle; D006454:Hemoglobins; D006455:Hemoglobins, Abnormal; D005914:Globins; D006444:Hemoglobin C