Immediate changes in plasma potassium, sodium and chloride concentrations induced by suxamethonium.
Four groups of healthy female patients were anaesthetized with wither thiopentone, Althesin or nitrous oxide-oxygen with and without halothane. The concentrations of the plasma electrolytes were measured before and at varying times up to 10 min after the administration of suxamethonium 1 mg/kg. Asmall, but significant, biphasic increase in plasma potassium concentration was found when suxamethonium was administered to patients in whom anaesthesia was induced with thiopentone, Althesin and nitrous oxide-oxygen. The initial increase in plasma potassium concentration was greater in the Althesin group thanin the other two groups. A more delayed, but sustained, increase in plasma potassium concentration was found following induction with nitrous oxide-oxygen-halothane. There were no significant changes in the plasma concentrations of sodium or chloride exceptin the halothane-nitrous oxide-oxygen series.
D000328:Adult; D000530:Alfaxalone Alfadolone Mixture; D000769:Anesthesia, Inhalation; D000771:Anesthesia, Intravenous; D002712:Chlorides / Q000097:blood*; D005260:Female; D006221:Halothane; D006801:Humans; D009609:Nitrous Oxide; D010100:Oxygen; D011188:Potassium / Q000097:blood*; D012964:Sodium / Q000097:blood*; D013268:Stimulation, Chemical; D013390:Succinylcholine / Q000494:pharmacology*; D013874:Thiopental; D013997:Time Factors
D002712:Chlorides; D000530:Alfaxalone Alfadolone Mixture; D012964:Sodium; D013390:Succinylcholine; D013874:Thiopental; D009609:Nitrous Oxide; D011188:Potassium; D010100:Oxygen; D006221:Halothane