Uptake ratio of (19-1311) cholesterol by adrenal glands as observed by a scintigraphic method.
The adrenal scintigram was performed after administration of [19-131I] cholesterol. A high/low ratio of both adrenal glands was calculated to evaluate whether there is a difference between the left and right sides in adrenal diseases. During scanning, information was stored in a 64 X 64 matrix and then punched out on a computer compatible paper tape. This paper tape was processed with a small digital computer. The areas of interest were selected over adrenal glands. The computer decided mean counts per unit area. After subtraction of background counts, a high/low ratio of adrenal gland was calculated. In five patients with Cushing's syndrome due to bilateral hyperplasia, a high/low ratio ranged from 1.0 to 2.0. In four patients with primary aldosteronism due to adenoma, a high/low ratio ranged from 1.33 to 4.0. This method may be useful to differentiate bilateral hyperplasia from unilateral adrenocortical adenoma.
D000236:Adenoma / Q000175:diagnosis; D000293:Adolescent; D000307:Adrenal Gland Diseases / Q000175:diagnosis*; D000310:Adrenal Gland Neoplasms / Q000175:diagnosis; D000311:Adrenal Glands / Q000378:metabolism*; D000308:Adrenocortical Hyperfunction / Q000175:diagnosis; D000328:Adult; D002784:Cholesterol / Q000378:metabolism*; D003201:Computers; D003480:Cushing Syndrome / Q000175:diagnosis; D005260:Female; D006801:Humans; D006929:Hyperaldosteronism / Q000175:diagnosis; D006965:Hyperplasia; D007457:Iodine Radioisotopes; D008297:Male; D008875:Middle Aged; D010673:Pheochromocytoma / Q000175:diagnosis; D011877:Radionuclide Imaging / Q000379:methods
D007457:Iodine Radioisotopes; D002784:Cholesterol