[Effect of propranolol on hemodynamic shifts and respiration during physical exertion in patients with hypertensive disease].
An examination of 25 patients with hypertensive disease of the I-II stage proved that following propranolol treatment the systolic and mean arterial pressure, the rate of cardiac contractions and the minute blood volume accrue on physical effort to a lesser extent, and the circulation time, diastolic pressure and peripheral resistance ot the blood flow-to the same degree as before the medication. Changes in the phasic structure of the left ventricle of the heart in physical exertion are less marked than they were prior to the treatment. Propranolol does not materially change the level of the oxygen consumption on effort; the lactic acid level and the ratio lactate/pyruvate in the blood rise against the background of the medication with this drug to a some-what lesser degree than before the treatment.
D001794:Blood Pressure / Q000187:drug effects; D001810:Blood Volume / Q000187:drug effects; D006321:Heart / Q000503:physiopathology; D006439:Hemodynamics / Q000187:drug effects*; D006801:Humans; D006973:Hypertension / Q000188:drug therapy / Q000503:physiopathology*; D005082:Physical Exertion; D011433:Propranolol / Q000494:pharmacology* / Q000627:therapeutic use; D012119:Respiration / Q000187:drug effects*; D014655:Vascular Resistance / Q000187:drug effects
D011433:Propranolol
Vliianie propranolola na gemodinamicheskie sdvigi i dykhanie pri fizicheskoĭ nagruzke u bol'nykh gipertonicheskoĭ bolezn'iu