Synthesis and antiarrhythmic activity of substituted (2-pyrimidinylthio)acetamidoximes.
A series of (2-pyrimidinylthiomethyl)carbonitriles and -carboxamidoximes was synthesized and the antiarrhythmic effects were evaluated against ventricular arrhythmias as measured by the electrical fibrillatory threshold in the anesthetized dog. Structure-activity studies indicated 2-[4-(p-chlorobenzylamino)-6-methyl-2-pyrimidinylthio]acetamidoxime dihydrochloride (6a) and 2-[4-(1,3-benzodioxol-5-ylmethylamino-6-propyl-2-pyrimidinylthio]acetamidoxime (6g) to be the most potent members of the series.
D000081:Acetamides / Q000138:chemical synthesis* / Q000627:therapeutic use; D000818:Animals; D000889:Anti-Arrhythmia Agents / Q000138:chemical synthesis* / Q000627:therapeutic use; D004285:Dogs; D004558:Electric Stimulation; D011743:Pyrimidines / Q000138:chemical synthesis* / Q000627:therapeutic use; D014693:Ventricular Fibrillation / Q000517:prevention & control
D000081:Acetamides; D000889:Anti-Arrhythmia Agents; D011743:Pyrimidines