Apomorphine as a discriminative stimulus, and its antagonism by haloperidol.
At a non-stereotypogenic dose (0.16 mg/kg, s.c.), apomorphine was shown to produce a discriminative stimulus in rats. The apomorphine-produced stimulus was found to be effectively antagonized by haloperidol. It is suggested that apomorphine's ability to stimulate central dopamine receptors is directly related to its cueing action.
D000818:Animals; D001058:Apomorphine / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D004193:Discrimination Learning / Q000187:drug effects*; D006220:Haloperidol / Q000494:pharmacology*; D051381:Rats
D006220:Haloperidol; D001058:Apomorphine