[Clinical and histopathological findings in mycoplasmal polyarthritis of rats. II. Course of disease between the 2. and 6. week (authors transl)].
Between the 9th and 42nd day p.i. the clinical features and microbiological findings of rats infected intraperitoneally with mycoplasma arthritidis were recorded and a histological investigation was carried out. From the 12th day p.i. arthritic lesions clinically showed a gradual regression. Until the 42nd day p.i. mycoplasmas and purulent exudate were present within the joint cavity. During the course of infection a gradual increase of mesenchymal cell activity was found, leading to the formation of considerable amounts of secondary synovialis. Between the epiphysis the pannus formed tissue laces, which after the 3rd week p. i. showed sequestration. During the further course of disease an increased number of focal plasma cell accumulations was observed within the joint capsule. Partial erosions of hyaline cartilage, especially near its edge, could frequently be seen. Within the cellular exudate of the joint cavity the number of macrophages steadily increased whereas remmants of exudate were mainly located in the recesses of the joint capsule. In the periarticular tissue, cellular infiltration, mesenchymal cell proliferation and purulent necrotic foci were present. In the supporting osseous tissues osteomyelitis, abscesses, periosteal new bone formation and the occurrence of mosaic bone could be observed. The lesions found in spleen and lymph-nodes indicated the persistence of a systemic reaction within the RES.
D000818:Animals; D001170:Arthritis, Infectious / Q000175:diagnosis* / Q000209:etiology / Q000473:pathology; D002358:Cartilage, Articular / Q000473:pathology; D003238:Connective Tissue; D008198:Lymph Nodes / Q000473:pathology; D008264:Macrophages; D009175:Mycoplasma Infections / Q000150:complications* / Q000175:diagnosis / Q000473:pathology; D010019:Osteomyelitis / Q000150:complications; D010950:Plasma Cells; D051381:Rats; D013154:Spleen / Q000473:pathology; D013997:Time Factors
Klinische und histopathologische Befunde bei der Mykoplasma-Polyarthritis der Ratte. II. Der Krankheitsablauf in der 2. bis 6. Woche