Effect of prostaglandin E2 on the pressor response to periarterial stimulation and norepinephrine of the isolated perfused rabbit kidney.
The interaction of prostaglandin E2 (PGE2) and aspirin with the responses to peri-arterial stimulation (PS) and norepinephrine (NE) was studied in the isolated kidney of rabbit perfused through the renal artery at constant flow with Krebs' solution. NE and PS increased vascular perfusion pressure of kidney and caused a contraction on the isolated rabbit aortic strip superfused with the effluent from kidney. Addition of PGE2 to the perfusion medium decreased the PS-induced rise in perfusion pressure without changing the effect of exogenous NE. In contrast, addition of aspirin to the perfusion medium induced a potentiation of the response to PS but not to NE. These results suggest that PGE2 modulates the effect of PS probably by inhibiting the releases of NE from sympathetic nerve endings.
D000818:Animals; D001011:Aorta / Q000187:drug effects; D001241:Aspirin / Q000494:pharmacology; D003864:Depression, Chemical; D004347:Drug Interactions; D004558:Electric Stimulation; D005260:Female; D007213:Indomethacin / Q000494:pharmacology; D007668:Kidney / Q000187:drug effects*; D008026:Ligation; D008297:Male; D009119:Muscle Contraction / Q000187:drug effects; D009638:Norepinephrine / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D010477:Perfusion; D011312:Pressure; D011458:Prostaglandins E / Q000494:pharmacology*; D011817:Rabbits; D012077:Renal Artery / Q000502:physiology; D013268:Stimulation, Chemical
D011458:Prostaglandins E; D001241:Aspirin; D009638:Norepinephrine; D007213:Indomethacin