[Cyclic hydrazides. II. (1) Synthesis of 3-aminopyrazolo[1,2-b]hthalazine-1(1H),5(10 H)-diones].
The synthesis is described of a number of 3-aminopyrazolo[1,2-b]phthalazine-1(1H),5(10H)-diones (I) differently substituted on the amino group and in position 2, through condensation of alpha-chloro-beta-chlorocarbonylenamines (IV) with the 3,4-dihydrophthalazin-1(2H)-one (III). Alternatively cyanoacetylchlorides are condensed with (III) giving directly the 3-aminopyrazolo[1,2-b]phthalazine-1(1H),5(10H)-diones with the primary amino function (VII).
D000893:Anti-Inflammatory Agents / Q000138:chemical synthesis*; D002626:Chemistry, Pharmaceutical; D006834:Hydrazines / Q000138:chemical synthesis*; D010793:Phthalazines / Q000138:chemical synthesis*; D011720:Pyrazoles / Q000138:chemical synthesis*; D011724:Pyridazines / Q000138:chemical synthesis*
D000893:Anti-Inflammatory Agents; D006834:Hydrazines; D010793:Phthalazines; D011720:Pyrazoles; D011724:Pyridazines
Idrazidi cicliche. II (1) - Sintesi di 3-aminopirazolo [1,2-b]ftalazin-1(1H),5(10H)-dioni