Antiviral quinolinehydrazones. A modified Free-Wilson analysis.
Eighty-four 4-quinolinehydrazones were synthesized and tested for antiviral activity. Thirty nine derivatives were active against influenza A2 and/or Coxsackie B1 in mice at a dose of 25 mg/kg sc. Structure-activity relationships of 44 derivatives (21 inactive) were analyzed qualitatively using a modified Free-Wilson approach.
D000818:Animals; D000998:Antiviral Agents / Q000138:chemical synthesis* / Q000627:therapeutic use; D003384:Coxsackievirus Infections / Q000188:drug therapy; D006561:Herpes Simplex / Q000188:drug therapy; D006835:Hydrazones / Q000138:chemical synthesis / Q000627:therapeutic use; D007700:Kinetics; D051379:Mice; D009976:Orthomyxoviridae Infections / Q000188:drug therapy; D011804:Quinolines / Q000138:chemical synthesis* / Q000627:therapeutic use; D013329:Structure-Activity Relationship
D000998:Antiviral Agents; D006835:Hydrazones; D011804:Quinolines