The direct gas chromatographic analysis of barbiturates as their sodium salts.
The addition of formic acid to the carrier gas will permit the on-column liberation of the free acids following the direct injection of barbiturates as their sodium salts. These free acids may then be resolved upon an Apiezon L column: the presence of formic acid also minimizes the adsorption effects which may be associated with the gas chromatographic analysis of these relatively polar drugs.
D001463:Barbiturates / Q000032:analysis*; D002849:Chromatography, Gas / Q000379:methods; D005561:Formates; D010424:Pentobarbital / Q000032:analysis; D010634:Phenobarbital / Q000032:analysis; D012964:Sodium / Q000032:analysis
D001463:Barbiturates; D005561:Formates; D012964:Sodium; D010424:Pentobarbital; D010634:Phenobarbital