Differential effects of fasting and nicotinic acid on various enzymatic activities of the 9,000 g fraction of the perfused rat liver.
Perfused livers obtained from rats fasted for 24 or 48h show a marked impairment of the N-demethylation (substrate aminopyrine) without major changes of the O-demethylation (p-nitro anisol) and hydroxylation (aniline). The infusion with nicotinic acid restored N-demethylation but it inhibited O-demethylation and hydroxylation.
D000632:Aminopyrine; D000633:Aminopyrine N-Demethylase / Q000378:metabolism*; D000814:Aniline Compounds / Q000378:metabolism; D000815:Aniline Hydroxylase / Q000378:metabolism*; D000818:Animals; D003864:Depression, Chemical; D005215:Fasting; D007539:Isonicotinic Acids / Q000494:pharmacology; D008297:Male; D008862:Microsomes, Liver / Q000187:drug effects / Q000201:enzymology*; D006899:Mixed Function Oxygenases / Q000378:metabolism*; D009539:Nicotinic Acids / Q000494:pharmacology*; D009575:Nitroanisole O-Demethylase / Q000378:metabolism*; D010088:Oxidoreductases / Q000378:metabolism*; D010477:Perfusion; D011725:Pyridines / Q000494:pharmacology; D051381:Rats; D013268:Stimulation, Chemical; D013997:Time Factors
D000814:Aniline Compounds; D007539:Isonicotinic Acids; D009539:Nicotinic Acids; D011725:Pyridines; D000632:Aminopyrine; D006899:Mixed Function Oxygenases; D009575:Nitroanisole O-Demethylase; D010088:Oxidoreductases; D000815:Aniline Hydroxylase; D000633:Aminopyrine N-Demethylase