Evidence for permanent enhancement of residual ADH induced by antidiuretic agents (chlorpropamide, carbamazepine, clofibrate) in patients with pituitary diabetes insipidus.
Excretion of free water was studied in 7 patients with pituitary diabetes insipidus before treatment and after withdrawal of antidiuretic drugs (chlorpropamide, carbamazepine, clofibrate) used on a long-term basis. A statistically significant decrease in free water clearance was found after 2-4 weeks of withdrawal of antidiuretic agents. This was considered as a clinical evidence for the permanently enhanced release of residual ADH induced by chlorpropamide, carbamazepine and clofibrate in patients with partial defect in ADH secretion.
D000293:Adolescent; D000328:Adult; D002220:Carbamazepine / Q000627:therapeutic use*; D002747:Chlorpropamide / Q000627:therapeutic use*; D002994:Clofibrate / Q000627:therapeutic use*; D003919:Diabetes Insipidus / Q000188:drug therapy* / Q000378:metabolism; D004231:Diuresis / Q000187:drug effects*; D004359:Drug Therapy, Combination; D005260:Female; D005919:Glomerular Filtration Rate; D006801:Humans; D008297:Male; D008875:Middle Aged; D014667:Vasopressins / Q000378:metabolism*
D014667:Vasopressins; D002220:Carbamazepine; D002994:Clofibrate; D002747:Chlorpropamide