Antiradiation compounds XV: condensations of carbon disulfide with amino, chloro, cyanomethyl, and sulfonamido heterocycles.
Condensations of carbon disulfide were carried out with amino, chloro, and diamino heterocycles to give condensed ring thiazoline-2-thiones and imidazoline-2-thiones, with cyanomethyl heterocycles to give dithio acid derivatives, and with heterocyclic sulfonamides to give sulfonyldithiocarbamates. Of several examples tested, pyrido[3,2-d]thiazoline-2-thione, disodium 2-(5-chloro-2-thienyl)-3,3-dimercaptoacrylonitrile, triethylammonium 4-sulfamoylphenyldithiocarbamate, ammonium beta-phenethyldithiocarbamate, and methyl N-(thiophene-2-sulfonyl)dithiocarbamate, only the last-named compound showed any radiation protection for mice. Several compounds gave negative tests for antimalarial activity.
D000097:Acetonitriles / Q000138:chemical synthesis*; D000588:Amines / Q000138:chemical synthesis*; D000818:Animals; D000962:Antimalarials / Q000138:chemical synthesis / Q000494:pharmacology; D002246:Carbon Disulfide / Q000138:chemical synthesis*; D055598:Chemical Phenomena; D002621:Chemistry; D002713:Chlorine; D006571:Heterocyclic Compounds / Q000138:chemical synthesis*; D051379:Mice; D011837:Radiation-Protective Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D013449:Sulfonamides / Q000138:chemical synthesis*
D000097:Acetonitriles; D000588:Amines; D000962:Antimalarials; D006571:Heterocyclic Compounds; D011837:Radiation-Protective Agents; D013449:Sulfonamides; D002713:Chlorine; D002246:Carbon Disulfide