Regional Myocardial Blood Flow Measurement in the Evaluation of Patients with Coronary Artery Disease.
Myocardial imaging with 133-Xe and a gamma camera was employed to evaluate total and regional myocardial blood flow. The technique detected vasodilatation after injection of papaverine or diatrizoate. Contrast medium caused transient vasodilatation with return to baseline flow within five minutes. Myocardial tissue flow tended to decrease as coronary artery stenosis became more severe. There was overlap of flow measurements in patients with and without coronary artery disease. Coronary flow measurements made at rest are not considered to be an essential clinical tool. gpreater diagnostic benefit is obtained from the scintigram which distinguishes between akinesia caused by ischemia and akinesia due to extensive scarring.
D003287:Contrast Media; D003326:Coronary Circulation / Q000187:drug effects; D003327:Coronary Disease / Q000175:diagnosis* / Q000503:physiopathology; D003973:Diatrizoate / Q000494:pharmacology; D006801:Humans; D010208:Papaverine / Q000494:pharmacology; D011877:Radionuclide Imaging; D014665:Vasodilator Agents / Q000494:pharmacology; D014980:Xenon Radioisotopes
D003287:Contrast Media; D014665:Vasodilator Agents; D014980:Xenon Radioisotopes; D003973:Diatrizoate; D010208:Papaverine