Oxidation of the carcinogens benzo [a] pyrene and benzo [a] anthracene to dihydrodiols by a bacterium.
A mutant strain of Beijerinckia, after growth with succinate plus biphenyl, contains an enzyme system that oxidizes benzo [a] pyrene and benzo [a] anthracene to mixtures of vicinal dihydrodiols. The major dihydrodiol formed from benzo [a] pyrene was identified as cis-9, 10-dihydroxy-9, 10-dihydrobenzo [a] pyrene by comparison with a synthetic sample. Benzo [a] anthracene was metabolized to four dihydrodiols, the major isomer being cis-1, 2-dihydroxy-1, 2-dihydroxy-1, 2-dihydrobenzo [a] anthracene.
D001395:Azotobacter / Q000378:metabolism*; D001551:Benz(a)Anthracenes / Q000378:metabolism*; D001580:Benzopyrenes / Q000378:metabolism*; D002855:Chromatography, Thin Layer; D009682:Magnetic Resonance Spectroscopy; D010084:Oxidation-Reduction; D013057:Spectrum Analysis
D001551:Benz(a)Anthracenes; D001580:Benzopyrenes