In vitro metabolism of ethionine, N-acetyl-ethionine and N-acetylmethionine by rat liver microsomes.
Rat liver microsomes deacetylated N-acetylethionine and N-acetyl-methionine to ethionine and methionine. The deacetylation of N-acetylmethionine was more rapid than the deacetylation of N-acetylethionine. Ethionine was slowly converted to ethionine sulfoxide by the microsomal preparations. N-Acetylethionine and N-acetylmethionine were not oxidized by the microsomes.
D000818:Animals; D005001:Ethionine / Q000031:analogs & derivatives / Q000378:metabolism*; D066298:In Vitro Techniques; D007700:Kinetics; D008297:Male; D008715:Methionine / Q000031:analogs & derivatives / Q000378:metabolism; D008862:Microsomes, Liver / Q000378:metabolism*; D051381:Rats; D013454:Sulfoxides / Q000378:metabolism
D013454:Sulfoxides; D008715:Methionine; D005001:Ethionine