[Thienyl acrylamides and thienyl pyrazolines as potential schistosomicidal agents].
Alpha-Thienyl-N-substituted acrylamides that possess analogous structures to known schistosomicidal agents were synthesized. Two chalcones were prepared by condensing alpha-thiophenealdehyde and acetophenone or its o-hydroxy derivative. Cyclization of the chalcones with hydrazine hydrate or monosubstituted hydrazines afforded 1.3.5 trisubstituted 2-pyrazoline
D000178:Acrylamides / Q000138:chemical synthesis*; D003500:Cyclization; D011720:Pyrazoles / Q000138:chemical synthesis*; D012556:Schistosomicides / Q000138:chemical synthesis*; D013876:Thiophenes / Q000138:chemical synthesis
D000178:Acrylamides; D011720:Pyrazoles; D012556:Schistosomicides; D013876:Thiophenes