Comparison of the effects of pentobarbital and chloralose on the cardiac rhythms of the dog in chronic atrio-ventricular heart block.
In the dog in chronic atrio-ventricular dissociation, pentobarbital at a dose of 25 mg/kg causes atrial tachycardia, but does not change the ventricular frequency. The vagolytic effect of pentobarbital explains this phenomenon. The pronounced vagal tonus seen in the Keith-Flack node, is not seen in the ventricle. Chloralose at a dose of 80 mg/kg i.v. does not alter atrial frequency but depresses ventricular frequency, in a significant way, for 40 min.
D000818:Animals; D002698:Chloralose / Q000494:pharmacology*; D004285:Dogs; D005260:Female; D006321:Heart / Q000187:drug effects*; D006325:Heart Atria / Q000187:drug effects; D006327:Heart Block; D006339:Heart Rate / Q000187:drug effects; D006352:Heart Ventricles / Q000187:drug effects; D008297:Male; D010424:Pentobarbital / Q000494:pharmacology*
D002698:Chloralose; D010424:Pentobarbital