Biochemical criteria for the evaluation of drug efficiency on adjuvant arthritis and nephrotoxic serum nephritis in the rat: studies with phenylbutazone, L-Asparaginase, colchicine, lysine acetylsalicylate, and pyridinol carbamate.
The levels of serum orosomucoid, haptoglobin, and seromucoid were evaluated as possible quantitative criteria for the estimation of drug efficiency in adjuvant arthritis and nephrotoxic serum nephritis. In adjuvant arthritis, haptoglobin, seromucoid, and chiefly orosomucoid serum levels were generally very sensitive to anti-inflammatory agents such as phenylbutazone and pyridinol carbamate, and to immunosuppressive agents such as L-asparaginase. There was a significant correlation between the serum levels of these glycoproteins and the arthritis scores. In nephrotoxic serum nephritis, seromucoid levels were correlated with the proteinuria of the autologous phase and were found to be a good complementary criterion for the analysis of the efficiency of pyridinol carbamate, colchicine, iysine acetylsalicylate, and L-asparaginase.
D000818:Animals; D001172:Arthritis, Rheumatoid / Q000097:blood / Q000188:drug therapy* / Q000276:immunology; D001215:Asparaginase / Q000494:pharmacology*; D001241:Aspirin / Q000494:pharmacology*; D001485:Basement Membrane / Q000276:immunology; D001798:Blood Proteins / Q000032:analysis; D002219:Carbamates / Q000494:pharmacology*; D003078:Colchicine / Q000494:pharmacology*; D005260:Female; D006242:Haptoglobins / Q000032:analysis; D007106:Immune Sera; D007678:Kidney Glomerulus / Q000276:immunology*; D007700:Kinetics; D008239:Lysine / Q000494:pharmacology*; D009393:Nephritis / Q000097:blood / Q000188:drug therapy* / Q000276:immunology; D009961:Orosomucoid / Q000032:analysis; D010653:Phenylbutazone / Q000494:pharmacology*; D011507:Proteinuria / Q000188:drug therapy; D011727:Pyridinolcarbamate / Q000494:pharmacology*; D051381:Rats
D001798:Blood Proteins; D002219:Carbamates; D006242:Haptoglobins; D007106:Immune Sera; D009961:Orosomucoid; D011727:Pyridinolcarbamate; D001215:Asparaginase; D010653:Phenylbutazone; D008239:Lysine; D001241:Aspirin; D003078:Colchicine