Comparison of analgesic effects of isosteric variations of salicylic acid and aspirin (acetylasalicylic acid).
A reliable and sensitive method was used to compare the analgesic activities of salicylic acid and aspirin (acetylsalicylic acid) and several phenoxy substituted isosteric pairs. Those isosteric compounds studied did not show analgesic activity. The analgesic activity of aspirin was more than twofold greater than that of salicylic acid.
D000700:Analgesics; D000818:Animals; D001241:Aspirin / Q000494:pharmacology* / Q000633:toxicity; D001565:Benzoates / Q000494:pharmacology; D001920:Bradykinin / Q000494:pharmacology; D007536:Isomerism; D007928:Lethal Dose 50; D008297:Male; D010146:Pain / Q000139:chemically induced; D051381:Rats; D012459:Salicylates / Q000494:pharmacology* / Q000633:toxicity; D013438:Sulfhydryl Compounds / Q000494:pharmacology; D062367:ortho-Aminobenzoates / Q000494:pharmacology
D000700:Analgesics; D001565:Benzoates; D012459:Salicylates; D013438:Sulfhydryl Compounds; D062367:ortho-Aminobenzoates; D001241:Aspirin; D001920:Bradykinin