Identification and quantitation of impurities in dapsone preparations.
Chromatographic and fluorometric procedures were developed to isolate and quantitate small amounts of 2,4'-diamino-diphenyl sulfone and 4-aminodiphenyl sulfone in pharmaceutical preparations of the antileprosy drug 4,4'-diaminodiphenyl sulfone (dapsone). Identification was accomplished by comparison with authentic compounds employing UV absorption, fluorometry, and mass spectrometry in addition to TLC and high-pressure liquid chromatography.
D002855:Chromatography, Thin Layer; D003622:Dapsone / Q000032:analysis*; D005470:Fluorometry; D008722:Methods; D013056:Spectrophotometry, Ultraviolet; D013450:Sulfones / Q000302:isolation & purification; D013607:Tablets / Q000032:analysis
D013450:Sulfones; D013607:Tablets; D003622:Dapsone