Histogenesis of the deep cerebellar nuclei in the mouse: an autoradiographic study.
In order to tag cells when they arise, pregnant mice were injected usually once or in some cases multiple times at a known time of gestation with tritiated thymidine. The offspring were killed and their brains prepared for autoradiography. Distribution of labeled cells was plotted using a drawing apparatus. Neurons of the deep cerebellar nuclei arise on gestation days 10-17. (Later periods were not studied.) Most neurons arise on gestation day 11. Many medium and small sized neurons arise after gestation day 11 with a limited number of small neurons observed to arise through the 17th day. Neurons for all parts of the complex arise at the same time, thus no gradients could be established.
D000818:Animals; D002529:Cerebellar Nuclei / Q000166:cytology / Q000196:embryology*; D005260:Female; D005865:Gestational Age; D008297:Male; D051379:Mice