Lymphocytic choriomeningitis in university hospital personnel. Clinical features.
Clinical manifestations of lymphocytic choriomeningitis (LCM) virus infection in 15 patients are described. These patients were University Hospital personnel who had had contact with hamsters, subsequently shown to harbor the virus. Fever with striking myalgias, headache and rigors were the most common symptoms. Only 2 of the 15 patients had clinically overt and documented aseptic meningitis. Leuikpenia was observed in 10 of 11 patients and thrombocytopenia in 8 of 8 patients tested. A biphasic illness was seen in eight patients. In a patient who has been exposed to laboratory animals, particularly to hamsters, a nonspecific influenza-like febrile illness accompanied by leukopenia and thrombocytopenia may represent LCM virus infection.
D000818:Animals; D000914:Antibodies, Viral / Q000032:analysis; D001219:Aspartate Aminotransferases / Q000032:analysis; D001772:Blood Cell Count; D001792:Blood Platelets; D002556:Cerebrospinal Fluid Proteins / Q000032:analysis; D003289:Convalescence; D006224:Cricetinae; D005947:Glucose / Q000134:cerebrospinal fluid; D006801:Humans; D007677:Kidney Function Tests; D007770:L-Lactate Dehydrogenase / Q000097:blood; D007757:Laboratory Infection / Q000175:diagnosis / Q000453:epidemiology*; D007958:Leukocyte Count; D008216:Lymphocytic Choriomeningitis / Q000175:diagnosis / Q000453:epidemiology*; D008217:Lymphocytic choriomeningitis virus / Q000302:isolation & purification; D009518:New York; D010564:Personnel, Hospital
D000914:Antibodies, Viral; D002556:Cerebrospinal Fluid Proteins; D007770:L-Lactate Dehydrogenase; D001219:Aspartate Aminotransferases; D005947:Glucose