The metabolism of chlorpromazine and promethazine to give new "pink spots". Proposals for the mechanisms involved.
Mechanisms are proposed for the removal, during metabolism, of the aminoalkyl side chain from chlorpromazine and promethazine and for the subsequent formation of nitroxides, N-hydroperoxides, N-oxyhydroperoxides and hydroxylamines from the phenothiazine nuclei.
D055598:Chemical Phenomena; D002621:Chemistry; D002746:Chlorpromazine / Q000378:metabolism*; D002855:Chromatography, Thin Layer; D004579:Electron Transport; D005420:Flavoproteins / Q000378:metabolism; D006898:Hydroxylamines / Q000096:biosynthesis; D010084:Oxidation-Reduction; D010100:Oxygen; D011398:Promethazine / Q000378:metabolism*
D005420:Flavoproteins; D006898:Hydroxylamines; D011398:Promethazine; D010100:Oxygen; D002746:Chlorpromazine