Ketoacids in the treatment of uremia.
Essential amino acid supplementation (EAA) was compared with supplementation by a mixture (KA) of keto-analogues of valine, leucine, isoleucine, methionine and phenylalanine, plus the four remaining essential amino acids in stable chronic uremics. When KA were given after EAA, urea appearance fell and N balance improved (9 studies). When EAA were given after KA (5 studies), urea appearance and N balance did not worsen significantly during the 4-9 days of observation. Seven patients, including one on chronic dialysis prior to therapy, were given KA for 3-9 months as outpatients. In three, renal function clearly improved. Five became asymptomatic for intervals of 3-8 months.
D000328:Adult; D000368:Aged; D000601:Amino Acids, Essential / Q000008:administration & dosage / Q000627:therapeutic use*; D003928:Diabetic Nephropathies / Q000188:drug therapy; D005260:Female; D005921:Glomerulonephritis / Q000188:drug therapy; D006801:Humans; D007651:Keto Acids / Q000008:administration & dosage / Q000627:therapeutic use*; D007677:Kidney Function Tests; D008297:Male; D008875:Middle Aged; D009400:Nephrosclerosis / Q000188:drug therapy; D009584:Nitrogen / Q000378:metabolism; D006435:Renal Dialysis; D014511:Uremia / Q000188:drug therapy*
D000601:Amino Acids, Essential; D007651:Keto Acids; D009584:Nitrogen