[Formation of norapinephrine in the rat brain after administration of ((+)-erythro-3,4-dihydroxyphenylserine(author's transl)].
Fluorescence microscopy of rat brains after administration of (+)-erythro-DOPS has been studied. (+)-erythro-DOPS induced an increase of brain NE part of which was formed in the capillary walls. The slight diminution of this increase when (+)-erythro-DOPS was administered after inhibition of peripheral decarboxylase, might result from the algebraic sum of two inversely acting processes: suppression of NE synthesis in the capillary walls and enhancement of parenchymatous NE in some brain areas. (+)-erythro-DOPS enters different brain structures non specifically and NE is formed in DA and 5-HT systems, displacing the amines especially at the terminals; the NE formed by (+)-erythro-DOPS in NE systems should be rapidly catabolised. Possible pharmacological effects of (+)-erythro-DOPS administration involve consideration of the lack of topical specificity of NE formation; the displacement of 5-HT and DA; and the fact (+)-erythro-DOPS produces (+)-NE, and not naturally occurring NE.
D000818:Animals; D001921:Brain / Q000098:blood supply / Q000166:cytology / Q000378:metabolism*; D002196:Capillaries / Q000378:metabolism; D002262:Carboxy-Lyases / Q000494:pharmacology; D015103:Droxidopa / Q000494:pharmacology; D005260:Female; D008297:Male; D008856:Microscopy, Fluorescence; D009638:Norepinephrine / Q000096:biosynthesis*; D051381:Rats; D012694:Serine / Q000031:analogs & derivatives*
D012694:Serine; D002262:Carboxy-Lyases; D015103:Droxidopa; D009638:Norepinephrine
Formation de noradrénaline dans le cerveau du rat aprés administration de (érythro-3,4-dihydroxyphenylsérine