Anitdiuretic effect of carbamazepine in diabetes insipidus.
A study was made of the effect of the antiepileptic carbamazepine on the water metabolism in 13 vasopressin-sensitive and 4 ADH-resistant diabetes insipidus patients. It was found that in 12 ADH-sensitive diabetes insipidus cases the drug decreased the urinary output and the free water clearance, and increased the urinary osmolarity. The diuresis did not change in ADH-resistant diabetes insipidus patients. The investigations suggest that carbamazepine exerts an ADH-like effect, and can be applied with good results in the treatment of ADH-sensitive diabetes insipidus.
D000293:Adolescent; D000328:Adult; D002220:Carbamazepine / Q000494:pharmacology* / Q000627:therapeutic use; D003404:Creatinine / Q000652:urine; D003919:Diabetes Insipidus / Q000188:drug therapy / Q000503:physiopathology*; D004231:Diuresis / Q000187:drug effects*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009994:Osmolar Concentration; D014667:Vasopressins / Q000494:pharmacology
D014667:Vasopressins; D002220:Carbamazepine; D003404:Creatinine