[Action on the isolated guinea-pig ileum and toxicity of some derivatives of 1,5-bis-(3,4-methylendioxyphenyl)-n. pentane].
The acute toxicity and the activity on isolated guinea pig ileum of some derivatives of 1,5-bis-(3,4-methylendioxyphenyl)-n.pentane are reported. The majority of such compounds showed clear antagonist activity towards BaCl2, acetylcholine, histamine and 5-HT contracting responses, generally greater than that of papaverine. In almost all cases the therapeutic index of these compounds, calculated as the ratio between mouse i.v. LD50 and ileum ED50, was greater than the therapeutic index of papaverine.
D000588:Amines / Q000494:pharmacology*; D000818:Animals; D002082:Butylamines / Q000494:pharmacology*; D004149:Dioxoles / Q000494:pharmacology*; D006168:Guinea Pigs; D007082:Ileum / Q000187:drug effects*; D009119:Muscle Contraction / Q000187:drug effects; D009130:Muscle, Smooth / Q000187:drug effects*; D010208:Papaverine / Q000494:pharmacology
D000588:Amines; D002082:Butylamines; D004149:Dioxoles; D010208:Papaverine
Attività sull'ileo isolato di cavia e tossicità di alcuni derivati dell'1,5-bis-(3,4-metilendiossifenil)-n.pentano