Structure-activity relationship in synthetic fibrinolytics. 2-Phenethynylcyclopropanecarboxylates.
The fibrinolytic activity of nine 2-phenethynylcyclopropanecarboxylates was measured in the hanging clot test. The structure-activity relationship is given by log 1/C equals 0.54 log P + 2.01 where P is the octanol-water partition coefficient of the carboxylate ion pair and C is the molar concentration of the drug. The equation obtained for the cyclopropanecarboxylates is compared with similar equations for benzoates, salicylates, and N-phenylanthranilates.
D000480:Alkynes / Q000138:chemical synthesis* / Q000494:pharmacology; D001780:Blood Coagulation Tests; D002264:Carboxylic Acids / Q000138:chemical synthesis / Q000494:pharmacology; D003521:Cyclopropanes / Q000138:chemical synthesis* / Q000494:pharmacology; D005343:Fibrinolytic Agents / Q000138:chemical synthesis*; D007700:Kinetics; D013329:Structure-Activity Relationship
D000480:Alkynes; D002264:Carboxylic Acids; D003521:Cyclopropanes; D005343:Fibrinolytic Agents