Comparison of some permeability properties of rat liver slices, liver cells in suspension, and in vivo-produced aggregates of dispersed liver cells.
It has been reported earlier that when rat liver is dispersed to a single cell  suspension, the parenchymal cells lose the ability to take up pyrimidine bases but acquire the ability to take up RNAase and macromolecular nucleic acids. It is now shown that these changes are largely reversed on intraperitoneal reaggregation of the parenchymal cells and that, in these respects, the aggregates behave more like the organized tissue than like the dispersed cells.
D000818:Animals; D001693:Biological Transport, Active; D002449:Cell Aggregation; D004269:DNA, Bacterial / Q000378:metabolism; D005260:Female; D066298:In Vitro Techniques; D008099:Liver / Q000166:cytology / Q000378:metabolism*; D008297:Male; D009696:Nucleic Acids / Q000378:metabolism; D009963:Orotic Acid / Q000378:metabolism; D010539:Permeability; D012329:RNA, Bacterial / Q000378:metabolism; D051381:Rats; D012260:Ribonucleases / Q000378:metabolism; D014498:Uracil / Q000378:metabolism; D014529:Uridine / Q000378:metabolism
D004269:DNA, Bacterial; D009696:Nucleic Acids; D012329:RNA, Bacterial; D014498:Uracil; D009963:Orotic Acid; D012260:Ribonucleases; D014529:Uridine