Treatment of experimental vasogenic cerebral edema with benzopyrones.
Vasogenic cerebral edema was induced in rabbits by cold injury. Benzopyrone treatment, started 15 min after freezing, significantly reduced both brain edema and the increased permeability of the blood-brain barrier. On the other hand benzopyrone-treatment was without any effect in cytotoxic brain edema induced in rats by triethyl tin poisoning.
D000818:Animals; D001578:Benzopyrans / Q000494:pharmacology / Q000627:therapeutic use*; D001812:Blood-Brain Barrier / Q000187:drug effects; D001929:Brain Edema / Q000139:chemically induced / Q000188:drug therapy* / Q000209:etiology; D003080:Cold Temperature / Q000009:adverse effects; D004195:Disease Models, Animal; D008297:Male; D011817:Rabbits; D013268:Stimulation, Chemical; D014001:Tin
D001578:Benzopyrans; D014001:Tin