Immunodiagnosis of a metastasis in a patient with a history of double malignant disease.
This paper discusses the use made of the antigenic specificity of malignant tumours in the diagnosis and subsequent management of a patient with secondary malignant disease who had previously been treated for both carcinoma of the breast and malignant melanoma. A comparatively simple, rapid test (leucocyte adherence inhibition) was used to determine the patient's antitumour immunoreactivity. Cell-mediated immunity against both types of tumour was detected, but this was accompanied by serum-blocking factor corresponding to melanoma only, which indicated that the secondary malignant disease was melanoma.
D000328:Adult; D001943:Breast Neoplasms; D002277:Carcinoma / Q000175:diagnosis*; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D007104:Immune Adherence Reaction; D007962:Leukocytes / Q000276:immunology; D008207:Lymphatic Metastasis; D008545:Melanoma / Q000175:diagnosis*; D009362:Neoplasm Metastasis; D009378:Neoplasms, Multiple Primary; D012878:Skin Neoplasms; D013125:Spinal Neoplasms / Q000175:diagnosis*