Nortriptyline hydrochloride in urology.
Forty female patients suffering for long periods from frequency, urgency, and dysuria without any definite organic cause received nortriptyline chloride for three weeks. In 75 percent there was either considerable improvement or total disappearance of urinary complaints. At the same time the in vitro effects of the drug were tested using the isometric muscle contraction technique. Nortriptyline was found to have anticholinergic properties. The importance of this effect in the clinical study and the possible mode of action of the drug are discussed.
D000109:Acetylcholine / Q000037:antagonists & inhibitors / Q000494:pharmacology; D000818:Animals; D002940:Circadian Rhythm; D005260:Female; D006801:Humans; D009119:Muscle Contraction / Q000187:drug effects; D009129:Muscle Tonus / Q000187:drug effects; D009661:Nortriptyline / Q000009:adverse effects / Q000494:pharmacology / Q000627:therapeutic use*; D051381:Rats; D013268:Stimulation, Chemical; D001743:Urinary Bladder / Q000503:physiopathology; D014552:Urinary Tract Infections / Q000188:drug therapy; D014555:Urination Disorders / Q000188:drug therapy*
D009661:Nortriptyline; D000109:Acetylcholine