Substituted 9-benzyladenines: inhibitors of inflammation associated with the delayed hypersensitivity skin reaction.
Members of a group of substituted 9-benzyladenines have been identified as effective inhibitors of inflammatory aspects of the delayed hypersensitivity skin reaction in the guinea-pig. Inhibitory activity was demonstrable in the efferent arc of the cell-mediated tuberculin and contact dermatitis (2,4-dinitrochlorobenzene) reactions. One of the compounds, 2-amino-9-benzyladenine, inhibited both turpentine-induced and histamine-induced inflammation in the skin. The toxicity and inhibitory activities of some of these compounds are discussed, and reference is made to the structurally related mercaptopurines.
D000225:Adenine / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000627:therapeutic use; D000818:Animals; D001593:Benzyl Compounds / Q000008:administration & dosage / Q000627:therapeutic use; D003877:Dermatitis, Contact / Q000188:drug therapy; D006168:Guinea Pigs; D006968:Hypersensitivity, Delayed / Q000188:drug therapy* / Q000473:pathology; D007249:Inflammation / Q000139:chemically induced / Q000188:drug therapy* / Q000473:pathology; D008297:Male; D012867:Skin / Q000473:pathology; D014374:Tuberculin Test
D001593:Benzyl Compounds; D000225:Adenine