Activity of prostaglandin E, F, A and B on sphincter, dilator and ciliary muscle preparations of the cat eye.
Both sphincter and dilator muscle preparations of the cat iris contract to prostaglandins; F-2alpha and E-2 are the most potent and A-1 and B-1 the least. Ciliary muscle strips relax to PG'S provided that the strips are precontracted. E-1, E-2 and often F-2alpha are more potent relaxants than the remaining PG's. The effects of PG'S ARE NOT ALTERED BY ALPHA OR BETA BLOCKADE NOR BY ATROPINE; HOWEVER, PROPRANOLOL BLOCKS THE PG induced relaxation of the ciliary muscle. The effects of PG's on the sphincter are antagonized by catecholamines; but the latter act synergistically in contracting the dilator and in relaxing the ciliary muscle. Indomethacin markedly potentiates the effects of PG's on all three muscle preparations.
D000818:Animals; D001285:Atropine / Q000494:pharmacology; D002415:Cats; D002924:Ciliary Body / Q000187:drug effects; D004357:Drug Synergism; D004837:Epinephrine / Q000494:pharmacology; D007213:Indomethacin / Q000494:pharmacology; D007498:Iris / Q000187:drug effects; D007545:Isoproterenol / Q000494:pharmacology; D009119:Muscle Contraction / Q000187:drug effects*; D009638:Norepinephrine / Q000494:pharmacology; D009801:Oculomotor Muscles / Q000187:drug effects*; D010830:Physostigmine / Q000494:pharmacology; D011433:Propranolol / Q000494:pharmacology; D011448:Prostaglandin Antagonists / Q000494:pharmacology; D011453:Prostaglandins / Q000494:pharmacology*; D011454:Prostaglandins A / Q000494:pharmacology; D011458:Prostaglandins E / Q000494:pharmacology; D011460:Prostaglandins F / Q000494:pharmacology; D013268:Stimulation, Chemical
D011448:Prostaglandin Antagonists; D011453:Prostaglandins; D011454:Prostaglandins A; D011458:Prostaglandins E; D011460:Prostaglandins F; D001285:Atropine; D010830:Physostigmine; D011433:Propranolol; D007545:Isoproterenol; D009638:Norepinephrine; D007213:Indomethacin; D004837:Epinephrine