Lipid peroxidation: a possible mechanism for paraquat toxicity.
The toxicity of the herbicide paraquat in mice, measured by the single dose lethal to 50 per cent of the animals after 7 days, was significantly enhanced by prior exposure to diets deficient in selenium or vitamin E and by pretreatment with diethyl maleate. These data suggest lipid peroxidation to be an important in vivo biochemical mechanism of paraquat toxicity as both selenium and vitamin E have antioxidant functions.
D000818:Animals; D005260:Female; D005979:Glutathione Peroxidase / Q000378:metabolism; D007928:Lethal Dose 50; D050356:Lipid Metabolism; D008298:Maleates / Q000494:pharmacology; D051379:Mice; D010269:Paraquat / Q000633:toxicity*; D010545:Peroxides / Q000378:metabolism*; D012643:Selenium / Q000172:deficiency; D014811:Vitamin E Deficiency / Q000201:enzymology
D008298:Maleates; D010545:Peroxides; D005979:Glutathione Peroxidase; D012643:Selenium; D010269:Paraquat