Thrombin-induced disseminated intravascular coagulation in the dog. I: Demonstration of microthrombi in lung.
Disseminated intravascular coagulation was induced in dogs by the infusion of a fibrinolytic inhibitor followed by thrombin. The deposition of microthrombi in the lung was demonstrated by radioactive labelling of platelets and fibrinogen.
D000614:Aminocaproates / Q000494:pharmacology; D000818:Animals; D001792:Blood Platelets; D002860:Chromium Radioisotopes; D004211:Disseminated Intravascular Coagulation / Q000139:chemically induced / Q000378:metabolism; D004285:Dogs; D005340:Fibrinogen / Q000378:metabolism; D007457:Iodine Radioisotopes; D008168:Lung / Q000378:metabolism; D008297:Male; D010949:Plasma; D013917:Thrombin / Q000494:pharmacology*; D013997:Time Factors
D000614:Aminocaproates; D002860:Chromium Radioisotopes; D007457:Iodine Radioisotopes; D005340:Fibrinogen; D013917:Thrombin