[In vitro investigations on the influence of various antirheumatic drugs on the enzymes of the purine salvage pathway (author's transl)].
On testing the effect of 5 drugs (azapropazone, flufenamic acid, indomethacin, oxyphenbutazone and prednisolone) commonly used in the therapy of rheumatic diseases on 3 enzymes of the purine salvage pathway (adenine-phosphoribosyltransferase, guanine-phosphoribosyltransferase and hypoxanthine-phosphoribosyltransferase) a distinct inhibitory effect of oxyphenbutazone and flufenamic acid was noted. A particularly marked effect was observed on adenine-phosphoribosyltransferase at the applied concentration (50 mug%) by both drugs but also guanine-phosphoribosyltransferase and hypoxanthine-phosphoribosyltransferase indicated reduced activities.
D000228:Adenine Phosphoribosyltransferase / Q000378:metabolism; D000893:Anti-Inflammatory Agents / Q000494:pharmacology*; D001032:Apazone / Q000494:pharmacology; D005439:Flufenamic Acid / Q000494:pharmacology; D006801:Humans; D007041:Hypoxanthine Phosphoribosyltransferase / Q000378:metabolism; D007213:Indomethacin / Q000494:pharmacology; D010113:Oxyphenbutazone / Q000494:pharmacology; D011239:Prednisolone / Q000494:pharmacology; D011687:Purines / Q000378:metabolism*
D000893:Anti-Inflammatory Agents; D011687:Purines; D005439:Flufenamic Acid; D011239:Prednisolone; D000228:Adenine Phosphoribosyltransferase; D007041:Hypoxanthine Phosphoribosyltransferase; D010113:Oxyphenbutazone; D001032:Apazone; D007213:Indomethacin
In-vitro-Untersuchungen über den Einfluss verschiedener Antirheumatika auf die Enzyme des Purin-Wiederverwertungsstoffwechsels