Comparative immunogenicity of HL-A antigens: a study in primiparas.
A comparison of immunogenic strength among 23 HL-A antigens was made by studying HL-A antibodies formed in primiparous women. In this setting of single pregnancies, each one of the incompatible fetal antigens would have an equal opportunity (one gestational period) to sensitize the mother. Three hundred pairs of primiparous women and newborns were HL-A typed and the serum of each mother was tested for antibody activity against the child's lymphocytes. The test was positive in 24 instances; 19 sera were reactive with only one antigen of paternal origin, one serum was reactive with both antigens, and in four instances the children's incompatible antigens were identified. When the frequencies of different antibody specificities were statistically analysed, HL-A5 and W14 were found to be distinctly more immunogenic than the other antigens.
D000917:Antibody Formation; D000918:Antibody Specificity; D005260:Female; D005333:Fetus / Q000276:immunology; D006680:HLA Antigens; D006238:Haploidy; D006649:Histocompatibility Antigens; D006650:Histocompatibility Testing; D006801:Humans; D007114:Immunization; D007231:Infant, Newborn; D008214:Lymphocytes / Q000276:immunology; D010298:Parity; D011247:Pregnancy
D006680:HLA Antigens; D006649:Histocompatibility Antigens