Ophthalmic manifestations of induced sickling of erythrocytes in Japanese sika deer (Cervus nippon).
Nine female Japanese sika deer (Cervus nippon) were used in a total of 25 experiments in which sickling was chemically induced. During these experiments, color fundic and color fluorescein photographs were taken. Fundic changes included retinal vascular attenuation, blood column pallor, and decreased tapetal reflectivity. These changes were most likely directly associated with a decreased hematocrit and a generalized shocklike condition. Three deer had a congested appearance in retinal blood vessels and tapetum lucidum. Two of the 3 deer developed serous detachment of the retina. These changes seemingly were associated with severe venous statis; all 3 deer died shortly after the experiment was terminated. These experiments yielded data only for the acutely affected deer. None of the ocular changes could be considered the result of chronic sickling because of the reversal of sickling that occurred despite continued intravenous administration of bicarbonate. None of the deer developed ocular changes characteristic of sickle cell retinopathy in human beings. The changes in human beings probably result from continued stress and prolongation of sickling, and especially from a multiplicity of repeated severe episodes of sickling occurring over many years.
D000471:Alkalosis / Q000662:veterinary; D000755:Anemia, Sickle Cell / Q000503:physiopathology / Q000662:veterinary*; D000818:Animals; D001639:Bicarbonates / Q000008:administration & dosage; D003670:Deer; D004596:Electroretinography; D004912:Erythrocytes; D005132:Eye Manifestations; D005260:Female; D005451:Fluorescein Angiography; D005654:Fundus Oculi; D007275:Injections, Intravenous; D007564:Japan; D012160:Retina / Q000503:physiopathology; D012163:Retinal Detachment / Q000473:pathology / Q000662:veterinary; D012171:Retinal Vessels / Q000503:physiopathology
D001639:Bicarbonates