Change in immunosensitivity of Yoshida sarcoma produced by chemical modification of cell-surface membrane.
Change in immunosensitivity of various chemically modified cells to the specific antibody was investigated in the Donryu rat-Yoshida sarcoma system. Among various agents, Amphotericin-B and cetyltrimethylammonium bromide were effective in increasing the immunosensitivity. This effect was not due to the general damage of cell membrane but to the increase of antigen exposed on the cell-surface membrane.
D000666:Amphotericin B / Q000494:pharmacology; D000818:Animals; D000951:Antigens, Neoplasm; D002462:Cell Membrane / Q000187:drug effects / Q000276:immunology; D002593:Cetrimonium Compounds / Q000494:pharmacology; D003601:Cytotoxicity Tests, Immunologic; D004586:Electrophoresis; D005260:Female; D006168:Guinea Pigs; D008214:Lymphocytes / Q000276:immunology; D009439:Neuraminidase / Q000494:pharmacology; D051381:Rats; D012517:Sarcoma, Yoshida / Q000276:immunology*
D000951:Antigens, Neoplasm; D002593:Cetrimonium Compounds; D000666:Amphotericin B; D009439:Neuraminidase