Recovery of catalase activity after inhibition with aminotriazole in acatalasemia mice.
The kinetics of catalase synthesis and degradation were determined in acatalasemia and normal mouse livers during recovery of catalase activity after inhibition with aminotriazole. Catalase turned over with a half life of 10.0 hr in acatalasemia mice and of 19.2 hr in normal mice. The rate of catalase synthesis (Ks) was 0.168 (PU/mg protein/hr) in acatalasemia mice and 0.271 in normal mice. The rate of catalase degradation (KD) was 0.069 and 0.036 per hour in acatalasemia and normal mice, respectively.
D000818:Animals; D002374:Catalase / Q000037:antagonists & inhibitors / Q000096:biosynthesis / Q000097:blood*; D006207:Half-Life; D007700:Kinetics; D008099:Liver / Q000201:enzymology; D008433:Mathematics; D051379:Mice; D014230:Triazoles / Q000494:pharmacology*
D014230:Triazoles; D002374:Catalase