Calcific cardiomyopathy in advanced renal failure.
Four uremic patients on maintenance hemodialysis developed intractable heart failure and atrioventricular block. All had persistently high (over 60) calcium-phosphorus products. At autopsy, all had metastatic myocardial calcification. Their inability to take phosphate-binding agents orally is responsible for this fatal complication.
D000328:Adult; D000536:Aluminum Hydroxide / Q000627:therapeutic use; D002114:Calcinosis / Q000150:complications*; D002118:Calcium / Q000097:blood; D002128:Calcium Metabolism Disorders / Q000188:drug therapy; D004388:Dura Mater / Q000473:pathology; D005260:Female; D006327:Heart Block / Q000150:complications; D006333:Heart Failure / Q000150:complications* / Q000209:etiology; D006801:Humans; D007676:Kidney Failure, Chronic / Q000150:complications*; D008168:Lung / Q000473:pathology; D008297:Male; D008875:Middle Aged; D009206:Myocardium / Q000473:pathology*; D010758:Phosphorus / Q000097:blood; D010760:Phosphorus Metabolism Disorders / Q000188:drug therapy
D010758:Phosphorus; D000536:Aluminum Hydroxide; D002118:Calcium