Liver glycogen accumulation after cyanate treatment.
Sodium cyanate has been proposed as a therapy for sickle cell anemia. Histologic studies have suggested abnormal accumulation of glycogen in livers of rats. Quantitative liver glycogen determinations reported here showed a significant increase (P smaller than 0.05), which, however, was mobilized normally during fasting and after glucagon injections.
D000818:Animals; D003485:Cyanates / Q000494:pharmacology*; D005934:Glucagon / Q000494:pharmacology; D008099:Liver / Q000033:anatomy & histology / Q000187:drug effects / Q000378:metabolism; D008112:Liver Glycogen / Q000378:metabolism*; D008297:Male; D051381:Rats; D013268:Stimulation, Chemical; D013997:Time Factors
D003485:Cyanates; D008112:Liver Glycogen; D005934:Glucagon