Treatment of solar keratoses with a 5-fluorouracil and salicylic acid varnish.
In an attempt to avoid the side-effects of treating solar keratoses with 5% 5-fluorouracil (5-FU) ointment, a new pharmacological varnish containing 5% 5-FU and 5-10% salicylic acid to collodium was tried. Twenty patients with such lesions were treated. A drop of the varnish was applied on each lesion every 3 weeks. Only one to five applications on facial lesions were necessary to obtain apparent cure in all patients. Lesions reappeared in four patients, but were cured after a second and similar treatment. The keratoses of the hands were more resistant and needed seven applications in one patient and nine in the other.
D000287:Administration, Topical; D000328:Adult; D000368:Aged; D003101:Collodion; D004338:Drug Combinations; D005260:Female; D005472:Fluorouracil / Q000008:administration & dosage* / Q000627:therapeutic use; D006225:Hand; D006801:Humans; D007642:Keratosis / Q000188:drug therapy* / Q000209:etiology; D008297:Male; D008875:Middle Aged; D010150:Paint; D012008:Recurrence; D012459:Salicylates / Q000008:administration & dosage* / Q000627:therapeutic use; D013472:Sunlight
D004338:Drug Combinations; D012459:Salicylates; D003101:Collodion; D005472:Fluorouracil