Potentiation of the adrenergic beta-receptor-mediated insulin secretion in pertussis-sensitized rats.
The increase in blood insulin level induced by adrenergic beta-stimulants, glucose and tolbutamide was strongly exaggerated in pertussis-sensitized rats. Moreover, the decrease in blood insulin caused by the alpha-receptor-mediated action of epinephrine in glucose- or tolbutamide-treated rats was effectively reversed by pertussis sensitization. The rise of blood insulin concentration due to adrenergic alpha-blockade was also enhanced by pertussis sensitization. It is concluded that the secretion of insulin resulting from the stimulation of adrenergic bate-receptor is enhanced by pertussis sensitization, probably due to activation of a process occurring in the chain of events leading to the discharge of insulin from the pancreatic beta-cell.
D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D003981:Diazoxide / Q000097:blood; D004837:Epinephrine / Q000494:pharmacology; D005934:Glucagon / Q000494:pharmacology; D005947:Glucose / Q000494:pharmacology; D006854:Hydrocortisone / Q000494:pharmacology; D007328:Insulin / Q000097:blood*; D007330:Insulin Antibodies; D007545:Isoproterenol / Q000494:pharmacology; D008297:Male; D009638:Norepinephrine / Q000494:pharmacology; D010567:Pertussis Vaccine; D010646:Phentolamine / Q000494:pharmacology; D010656:Phenylephrine / Q000494:pharmacology; D051381:Rats / Q000276:immunology; D011941:Receptors, Adrenergic; D013997:Time Factors; D014044:Tolbutamide / Q000494:pharmacology; D014917:Whooping Cough / Q000097:blood / Q000276:immunology*
D001786:Blood Glucose; D007328:Insulin; D007330:Insulin Antibodies; D010567:Pertussis Vaccine; D011941:Receptors, Adrenergic; D010656:Phenylephrine; D005934:Glucagon; D014044:Tolbutamide; D005947:Glucose; D007545:Isoproterenol; D003981:Diazoxide; D006854:Hydrocortisone; D009638:Norepinephrine; D004837:Epinephrine; D010646:Phentolamine