Cardiac sensitivity to hyperkalemia in adrenalectomized dogs.
In dogs with bilateral adrenalectomy loaded with K by infusion of 2 mEq KCI/kg/hr there is a marked increase of cardiac sensitivity to hyperkalemia. Typical ECG changes begin at lower serum K levels (5-6 mEq/l) and the prelethal arrhythmias that signal the imminent onset of fatal when mean serum K is 7.6 mEq/l, 2.9 mEq/l above the average pre-infusion level. In control dogs, ECG changes start above 8 mEq K/liter, and prelethal arrhythmias appear between 9.5 and 10.2 mEq/l, a mean increase of 5.6 mEq/l above the average preinfusion level.
D000311:Adrenal Glands / Q000502:physiology*; D000315:Adrenalectomy; D000818:Animals; D001145:Arrhythmias, Cardiac / Q000139:chemically induced; D004285:Dogs; D004562:Electrocardiography; D005260:Female; D006321:Heart / Q000503:physiopathology*; D006947:Hyperkalemia / Q000503:physiopathology*; D008297:Male; D010477:Perfusion; D011188:Potassium / Q000097:blood; D011189:Potassium Chloride / Q000008:administration & dosage / Q000494:pharmacology; D013997:Time Factors
D011189:Potassium Chloride; D011188:Potassium