Aspirin dosages for the dog.
Aspirin dosages calculated from published pharmacokinetic data were tested in 3 male and 3 female Basset Hounds. Emesis occurred frequently after dosing at the rate of 50 mg/kg of body weight, a dosage that would be required for a convenient 12-hour dosing interval. A dosage of 25 mg/kg every 12 hours avoided emesis but did not maintain serum salicylate concentrations within the desired range of 10 to 30 mg/100 ml. A dosage of 25 mg/kg every 8 hours resulted in serum salicylate concentrations varying from 12.5 to 17.8 mg/100 ml. It was concluded that a maintenance dosage of 25 to 35 mg/kg every 8 hours in optimal for the dog, based on extrapolation of data obtained in man.
D000284:Administration, Oral; D000818:Animals; D001241:Aspirin / Q000008:administration & dosage* / Q000633:toxicity; D004283:Dog Diseases / Q000139:chemically induced; D004285:Dogs / Q000097:blood*; D005260:Female; D008297:Male; D012459:Salicylates / Q000097:blood; D013997:Time Factors; D014839:Vomiting / Q000139:chemically induced / Q000662:veterinary
D012459:Salicylates; D001241:Aspirin