[Renal inhibitor of erythropoietin].
The soluble fraction of the rat and rabbit renal homogenate (normal, after acute blood loss or cobalt chlorate administration) contains an erythropoietin inhibitor and interferes with transformation of the renal erythropoiesis--stimulating factor into erythropoietin. After subcutaneous administration of this fraction in intact rats, an erythropoiesis inhibitor was revealed in their plasma.
D000818:Animals; D004900:Erythroblasts / Q000187:drug effects; D004906:Erythrocyte Count; D004920:Erythropoiesis / Q000187:drug effects; D004921:Erythropoietin / Q000096:biosynthesis*; D006454:Hemoglobins / Q000032:analysis; D007668:Kidney; D008938:Mitosis / Q000187:drug effects; D011817:Rabbits; D051381:Rats; D012156:Reticulocytes / Q000187:drug effects; D014020:Tissue Extracts / Q000494:pharmacology*
D006454:Hemoglobins; D014020:Tissue Extracts; D004921:Erythropoietin
Pochechnyĭ ingibitor éritropoétina