Advanced heart block aggravated by carbamazepine.
This report presents a serious adverse reaction to the anticonvulsant compound carbamazepine. A woman was admitted to hospital for recurrent attacks of syncope. She suffered from atrioventricular block of the Mobitz type II. Carbamazepine suppressed the conduction in her already defective Purkinje fibres and induced ventricular stand-still with subsequent Adams-Stokes attacks.
D000219:Adams-Stokes Syndrome / Q000139:chemically induced; D000368:Aged; D002220:Carbamazepine / Q000009:adverse effects* / Q000494:pharmacology / Q000627:therapeutic use; D005260:Female; D006327:Heart Block / Q000139:chemically induced* / Q000188:drug therapy; D006329:Heart Conduction System / Q000187:drug effects; D006801:Humans; D013575:Syncope / Q000188:drug therapy
D002220:Carbamazepine