Effects of high-molecular levan on the growth and spread of lymphoma in AKR mice.
Levan was shown to inhibit lymphoma development in AKR mice. Growth of tumor was inhibited at the site of injection and in metastases. Levan caused a decrease in the incidence of tumors, and it reduced pleomorphism, mitoses, and invasiveness of tumors in comparison to nonlevanized mice. Evidence of tumor cell destruction was observed in levanized mice. The effect of levan on tumor development was dose dependent.
D000818:Animals; D004305:Dose-Response Relationship, Drug; D004754:Enterobacter / Q000276:immunology; D005632:Fructose / Q000627:therapeutic use; D008113:Liver Neoplasms / Q000473:pathology; D008198:Lymph Nodes / Q000473:pathology; D008223:Lymphoma / Q000188:drug therapy* / Q000473:pathology; D008297:Male; D051379:Mice; D008806:Mice, Inbred AKR; D008970:Molecular Weight; D009362:Neoplasm Metastasis; D009368:Neoplasm Transplantation; D009374:Neoplasms, Experimental / Q000188:drug therapy; D011135:Polysaccharides, Bacterial / Q000008:administration & dosage / Q000627:therapeutic use* / Q000633:toxicity; D013997:Time Factors
D011135:Polysaccharides, Bacterial; D005632:Fructose