Chlordiazepoxide metabolism in mice following hepatic irradiation.
Biotransformation of chlordiazepoxide was studied in mice following a single 1000-rad dose of hepatic irradiation. Meabolic N-demethylation of chlordiazepoxide in irradiated mice was impaired when tested 3 days after irradiation. No such effect was observed in mice tested 3 weeks or 6 weeks after irradiation. Thus, hepatic irradiation appeared to produce short-lived, reversible impairment of drug-metabolizing function. The effect was small and of uncertain biological significance.
D000818:Animals; D001711:Biotransformation / Q000528:radiation effects; D002707:Chlordiazepoxide / Q000097:blood / Q000378:metabolism*; D008099:Liver / Q000528:radiation effects*; D008297:Male; D051379:Mice; D011830:Radiation Effects; D013997:Time Factors
D002707:Chlordiazepoxide