Studies on the behavioural pharmacology of a cyclic analogue of dopamine following its injection into the brains of conscious rats.
1. The cyclic analogue of dopamine, 2-amino-6,7-dihydroxy-1,2,3,4-tetrahydronaphthalene (ADTN) was injected into the lateral ventricle or bilaterally into the nucleus accumbens or caudate nucleus of conscious rats and its effect on locomotor activity was investigated. 2. When given intraventricularly, ADTN produced some stereotyped responses which were followed by a strong and long lasting stimulation of locomotor activity. When administered bilaterally into the nucleus accumbens a similar stimulation of locomotor activity was observed. ADTN had no effect on locomotor activity when injected bilaterally into the caudate nucleus. 3. The ADTN-induced locomotor stimulation following its intraventricular injection was completely abolished by a low dose of pimozide (0.01 mg/kg, i.p.) or haloperidol (0.5 mg/kg, i.p.). Pimozide (1 mg/kg, i.p.) given 30 min before ADTN injected bilaterally into the nucleus accumbens completely blocked locomotor stimulation. 4. Unilateral injections of ADTN (5 mug) into the nucleus accumbens caused locomotor stimulation but no turning. 5. Bilateral injections into the nucleus accumbens of 2-amino-6,7-dimethoxy-1,2,3,4-tetrahydronaphthalene or 0.9 percent w/v NaCl solution had no effect on locomotor activity. 6. It is concluded that the central stimulant action of ADTN is due to an effect on the dopamine receptors in the nucleus accumbens.
D000818:Animals; D001921:Brain / Q000187:drug effects; D002421:Caudate Nucleus / Q000187:drug effects; D002552:Cerebral Ventricles / Q000187:drug effects; D004298:Dopamine / Q000031:analogs & derivatives* / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D006220:Haloperidol / Q000494:pharmacology; D008297:Male; D009043:Motor Activity / Q000187:drug effects*; D010868:Pimozide / Q000494:pharmacology; D051381:Rats; D013268:Stimulation, Chemical
D010868:Pimozide; D006220:Haloperidol; D004298:Dopamine