A comparison of chlormethiazole and diazepam as intravenous sedatives for fibre-endoscopic examination of the upper gastrointestinal tract.
Chlormethiazole and diazepam as intravenous sedatives were compared in 75 patients undergoing fibre-endoscopic examination of the upper gastrointestinal tract. Diazepam was considered to offer greater reliability and ease of administration. Chlormethiazole wqs found to be a safe drug and did not encourage salivation. Local pain caused by chlormethiazole injection can be abolished by the use of lignocaine. Chlormethiazole may be useful in patients who are hypotensive and who require emergency endoscopy.
D000328:Adult; D000367:Age Factors; D000368:Aged; D001794:Blood Pressure / Q000187:drug effects; D002719:Chlormethiazole / Q000494:pharmacology*; D003975:Diazepam / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D004562:Electrocardiography; D004724:Endoscopy; D005260:Female; D005336:Fiber Optic Technology; D006461:Hemolysis; D006801:Humans; D006993:Hypnotics and Sedatives; D001239:Inhalation; D007275:Injections, Intravenous; D007422:Intestines; D008168:Lung; D008297:Male; D008875:Middle Aged; D011674:Pulse / Q000187:drug effects; D013270:Stomach
D006993:Hypnotics and Sedatives; D002719:Chlormethiazole; D003975:Diazepam