"Ground-glass" hepatocytes.
"Ground-glass" hepatocytes are liver cells which have eosinophilic granular, glassy cytoplasm on light microscopy. This appearance corresponds to a proliferated smooth endoplasmic reticulum ultrastructure. These changes may be drug-induced or associated with hepatitis B antigenaemia, particularly in carriers. In the latter case, hepatitis B antigen may be demonstrated in the liver cell cytoplasm, with a modified orcein stain, by immunofluorescence, electron microscopy and immuno-electron microscopy. Two patients are described in whom "ground-glass" hepatocytes were noted on liver biopsy. One patient had been treated with high doses of phenobarbitone, the other is a hepatitis B antigen carrier as was demonstrated by the modified orcein stain.
D000328:Adult; D001706:Biopsy; D002353:Carrier State / Q000382:microbiology / Q000473:pathology*; D056486:Chemical and Drug Induced Liver Injury / Q000209:etiology / Q000473:pathology*; D005260:Female; D006509:Hepatitis B / Q000382:microbiology / Q000473:pathology*; D006511:Hepatitis B Antigens / Q000032:analysis; D006801:Humans; D007231:Infant, Newborn; D007232:Infant, Newborn, Diseases / Q000139:chemically induced / Q000473:pathology*; D008099:Liver / Q000382:microbiology / Q000473:pathology* / Q000648:ultrastructure; D008297:Male; D010634:Phenobarbital / Q000009:adverse effects
D006511:Hepatitis B Antigens; D010634:Phenobarbital