[The distribution of ampicillin between blood and cerebrospinal fluid in patients with and without serous meningitis (author's transl)].
1. With a constant plasma concentration of Ampicillin the ratio of concentration in the cerebrospinal fluid to concentration in the plasma reaches a constant value after 2 hrs in patients with and without serous meningitis. 2. Patients without serous meningitis have a value of 0.025, patients with serous meningitis a value of 0.061. 3. From this it can be calculated that Ampicillin passes two and a half times faster through inflamed meningeal membranes than unaffected membranes.
D000667:Ampicillin / Q000032:analysis* / Q000097:blood / Q000134:cerebrospinal fluid; D001812:Blood-Brain Barrier; D002648:Child; D002675:Child, Preschool; D006801:Humans; D008581:Meningitis / Q000097:blood / Q000134:cerebrospinal fluid / Q000378:metabolism*; D013997:Time Factors
D000667:Ampicillin
Blut-Liquor-Verteilung von Ampicillin bei Patienten mit und ohne seröse Meningitis