Injury and repair of tracheobronchial cartilage following accidental exposure to ehtyleneimine.
A fatal case following ehtyleneimine inhalation is described. Profound destructive effects on tracheobronchial cartilage were found at necropsy after an interval of apparent recovery from early phases of poisoning. The pathogenesis of these cartilaginous changes is discussed. It is proposed that they may have been due to proteases liberated from liberated from mucosal granulation tissue.
D000818:Animals; D001344:Autopsy; D001980:Bronchi / Q000473:pathology*; D001986:Bronchial Spasm / Q000139:chemically induced; D002356:Cartilage / Q000473:pathology; D004724:Endoscopy; D005030:Ethylenes / Q000506:poisoning / Q000633:toxicity; D006099:Granuloma / Q000139:chemically induced; D006168:Guinea Pigs; D006801:Humans; D006854:Hydrocortisone / Q000627:therapeutic use; D007097:Imines / Q000506:poisoning*; D008297:Male; D008875:Middle Aged; D011654:Pulmonary Edema / Q000139:chemically induced* / Q000473:pathology; D011817:Rabbits; D051381:Rats; D012008:Recurrence; D014132:Trachea / Q000473:pathology*; D014135:Tracheal Stenosis / Q000139:chemically induced; D014140:Tracheotomy
D005030:Ethylenes; D007097:Imines; D006854:Hydrocortisone