Polygraphic night sleep pattern during chronic single and multiple neuroleptic dose administration.
A comparison was made between the polygraphic night-sleep pattern of chronic schizophrenic patients who were receiving a single dose of neuroleptics at bedtime and between the night-sleep pattern of the same patients receiving the same amount of the same neuroleptic divided into 3-4 doses during daytime. It was shown that the single bedtime dose provoked a significant increase in the mean percentage of the NREM stage 4 and of the mean percentage of the REM state whereas the mean percentage of the NREM stage 2 was significantly decreased.
D000328:Adult; D004569:Electroencephalography; D004576:Electromyography; D004585:Electrooculography; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011569:Psychiatric Status Rating Scales; D012559:Schizophrenia / Q000188:drug therapy; D012890:Sleep / Q000187:drug effects*; D013997:Time Factors; D014149:Tranquilizing Agents / Q000009:adverse effects / Q000494:pharmacology* / Q000627:therapeutic use
D014149:Tranquilizing Agents