The use of methylprednisolone during cardiopulmonary bypass. A review of 427 cases.
A study was designed to evaluate the hemodynamic effects of massive doses of methylprednisolone (30 mg. per kilogram) during cardiopulmonary bypass at normothermia and hypothermia. In 427 patients studied, significantly less vasoconstriction (p less than 0.01) and improved perfusion flows (p less than 0.0005) were obtained at comparable pressure levels in the steroid-treated group (272 patients) compared with the control group (155 patients). Because of these measured parameters, methylprednisolone should be considered a valuable adjunct to improving tissue perfusion during cardiopulmonary bypass.
D000768:Anesthesia, General; D001021:Aortic Valve / Q000601:surgery; D001794:Blood Pressure / Q000187:drug effects; D001831:Body Temperature; D002315:Cardiopulmonary Bypass; D003331:Coronary Vessels / Q000601:surgery; D005112:Extracorporeal Circulation; D006344:Heart Septal Defects, Atrial / Q000601:surgery; D006801:Humans; D007036:Hypothermia, Induced; D007902:Length of Stay; D008775:Methylprednisolone / Q000494:pharmacology*; D008943:Mitral Valve / Q000601:surgery; D010477:Perfusion; D014655:Vascular Resistance / Q000187:drug effects
D008775:Methylprednisolone