Pentagastrin increases phenylalanine and decreases histidine incorporation to proteins of rat stomach.
Female rats were treated with L-phenylalanine-14C or L-histidine-14C, 20 mug/kg i.p. one hour before receiving pentagastrin 250 mug/kg s.c. Sixty minutes after injection of pentagastrin the incorporation of L-phenylalanine-14C into the proteins of the squamous and fundic portions of the stomach was significantly increased respectively by 18 and 17.5%. On the contrary, the uptake of Lhistidine-14C into the proteins of the squamous (-24%), fundic (-18% and duodenal (-16%) regions was significantly decreased. Incorporation of histidine and phenylalanine into the proteins of the pylorus was not significantly affected by pentagastrin.
D000818:Animals; D002250:Carbon Radioisotopes; D003864:Depression, Chemical; D004386:Duodenum / Q000378:metabolism; D005260:Female; D005753:Gastric Mucosa / Q000378:metabolism*; D006639:Histidine / Q000378:metabolism*; D010418:Pentagastrin / Q000494:pharmacology*; D010649:Phenylalanine / Q000378:metabolism*; D014176:Protein Biosynthesis; D011708:Pylorus / Q000378:metabolism; D051381:Rats; D013268:Stimulation, Chemical; D013270:Stomach / Q000187:drug effects
D002250:Carbon Radioisotopes; D010649:Phenylalanine; D006639:Histidine; D010418:Pentagastrin