Hydrodynamic analog model for pharmacokinetics I: model and its usefulness.
A novel hydrodynamic model for drug distribution, when the drug is administered intravenously in physiological systems, is presented. In addition to obtaining results of familiar multicompartment models, the theory presents fresh insights into pharmacokinetic problems. A detailed procedure is included for evaluating drug-physiological system parameters such as the elimination rate constant, volumes of distribution, and permeability properties from the experimental time course of concentration of the central compartment.
D004058:Diffusion; D007700:Kinetics; D008954:Models, Biological; D010539:Permeability; D004364:Pharmaceutical Preparations / Q000378:metabolism*
D004364:Pharmaceutical Preparations