Evaluation of the teratogenic potential of a spray adhesive in hamsters.
Pregnant Syrian hamsters were placed in a 100-1 static inhalation chamber for 30 min twice daily on days 5-10 of gestation and exposed to 8.0 +/- 0.13, 11.6 +/- 0.11,or 13.23 +/- 0.49 g of "Foil Art Adhesive" and killed on day 14. Controls were placed in adjacent identical chambers but received no spray. The spray adhesive was toxic but not teratogenic at the doses administered. Maternal alopecia occurred upon exposure to the 2 highest dose levels, and 1 female died during exposure to the highest dose level. Fetal survival was not affected. Mean fetal weight was significantly decreased after exposure to all 3 dose levels, and delayed skeletal development occurred but was not dose related.
D000014:Abnormalities, Drug-Induced; D000336:Aerosols; D000505:Alopecia / Q000139:chemically induced; D000818:Animals; D001835:Body Weight; D002070:Butadienes; D006224:Cricetinae; D004305:Dose-Response Relationship, Drug; D005260:Female; D005313:Fetal Death; D005333:Fetus / Q000187:drug effects* / Q000502:physiology; D006128:Growth; D008647:Mesocricetus; D011247:Pregnancy; D012116:Resins, Plant; D013343:Styrenes; D013723:Teratogens
D000336:Aerosols; D002070:Butadienes; D012116:Resins, Plant; D013343:Styrenes; D013723:Teratogens