Action of tetrodotoxin on the contractile responses of isolated guinea-pig urinary bladder preparation to x-irradiation and to electrical stimulation.
Tetrodotoxin (10- minus 8 to 10- minus 6 g/ml) blocked the contractile responses of isolated guinea-pig urinary bladder preparation to electrical (25 and 100 Hz) neural but not to transmural stimulation and to X-irradiation (50 kV, 20 kR/min, 20 kR). The irradiation had no influence on the bladder responses to electrical and hormonal (acetylcholine and histamine) stimulation. It is concluded that the X-ray-induced contraction is of myogenic origin and that it is possibly not related to the electro-mechanical coupling system.
D000109:Acetylcholine / Q000494:pharmacology; D000200:Action Potentials; D000818:Animals; D004558:Electric Stimulation; D006168:Guinea Pigs; D006632:Histamine / Q000494:pharmacology; D066298:In Vitro Techniques; D008297:Male; D009119:Muscle Contraction; D009129:Muscle Tonus / Q000528:radiation effects; D009130:Muscle, Smooth / Q000187:drug effects / Q000502:physiology* / Q000528:radiation effects; D011830:Radiation Effects; D013779:Tetrodotoxin / Q000494:pharmacology*; D001743:Urinary Bladder / Q000187:drug effects / Q000502:physiology* / Q000528:radiation effects
D013779:Tetrodotoxin; D006632:Histamine; D000109:Acetylcholine