Supersensitivity of caudate neurones after repeated administration of haloperidol.
The microiontophoretic potencies of dopamine, apomorphine and alpha-aminobutyric acid were examined on caudate neurones, using the same electrodes, in control animals and animals that had received 2mg/kg/day of haloperidol for 9 days. In the haloperidol group, a greater percentage of cells were inhibited by dopamine and apomorphine, indicating the development of a post-synaptic supersensitivity.
D000818:Animals; D001058:Apomorphine / Q000494:pharmacology; D002421:Caudate Nucleus / Q000187:drug effects*; D004298:Dopamine / Q000494:pharmacology; D006220:Haloperidol / Q000494:pharmacology*; D066298:In Vitro Techniques; D007478:Iontophoresis; D008297:Male; D009474:Neurons / Q000187:drug effects*; D051381:Rats; D005680:gamma-Aminobutyric Acid / Q000494:pharmacology
D005680:gamma-Aminobutyric Acid; D006220:Haloperidol; D001058:Apomorphine; D004298:Dopamine