Experimental study of the combined effect of leukeran, degranol and predisolone.
The effect of the combined treatment with leukeran, degranol and prednisolone on the lymphoid tissue and marrow hamopoiesis in rats is studied. The simultaneous administration of these drugs is shown to cause a more effective inhibition of the lymphoid tissue and a less suppression of the marrow, as compared with their separate administration.
D000818:Animals; D001853:Bone Marrow / Q000187:drug effects*; D002699:Chlorambucil / Q000008:administration & dosage* / Q000494:pharmacology; D005260:Female; D007958:Leukocyte Count; D008221:Lymphoid Tissue / Q000187:drug effects*; D008357:Mannomustine / Q000008:administration & dosage* / Q000494:pharmacology; D011239:Prednisolone / Q000008:administration & dosage* / Q000494:pharmacology; D051381:Rats; D013154:Spleen / Q000187:drug effects
D002699:Chlorambucil; D011239:Prednisolone; D008357:Mannomustine