[Effect of actinomycin D on cell proliferation induced by phytohemagglutinin in human lymphocytes].
Actinomycin D at a dose inhibiting the synthesis of ribosomal RNA (0.15 MUG/ML) BLOCKS THE TRANSITION OF CELLS INTO ACTIVE PROLIFERATION DURING THE FIRST 6 HOURS AFTER PHYTOHAEMAGGLUTININ TREATMENT. The effect of actinomycin D becomes weaker as the cells proceed through the prereplicative period. 1 mug/ml actinomycin D blocks the synthesis of all RNSs. It has been found that actinomycin D at this concentration blocks the transition of cells into the proliferation during the entire prereplicative period.
D000596:Amino Acids; D002250:Carbon Radioisotopes; D003609:Dactinomycin / Q000494:pharmacology*; D006801:Humans; D037102:Lectins / Q000494:pharmacology; D008213:Lymphocyte Activation / Q000187:drug effects*; D008938:Mitosis / Q000187:drug effects; D012313:RNA / Q000096:biosynthesis; D013936:Thymidine; D014316:Tritium
D000596:Amino Acids; D002250:Carbon Radioisotopes; D037102:Lectins; D014316:Tritium; D003609:Dactinomycin; D012313:RNA; D013936:Thymidine
Deĭstvie aktinomitsina D na kletochnuiu proliferatsiiu, indutsirovannuiu v limfotsitakh cheloveka fitogemaggliutininom