Amitriptyline-perphenazine overdose producing delayed hypomania in manic-depressive illness.
The authors describe a 26-year-old woman who became hypomanic after awakening from a semicomatose state induced by an overdose of amitriptyline-perphenazine (Triavil). She had been depressed and had a strong family history of manic-depressive illness. The case is reported to support previous evidence that dopamine is a mediator for mania.
D000328:Adult; D000639:Amitriptyline / Q000506:poisoning*; D001714:Bipolar Disorder / Q000188:drug therapy / Q000503:physiopathology*; D018492:Dopamine Antagonists; D005260:Female; D006801:Humans; D010546:Perphenazine / Q000494:pharmacology / Q000506:poisoning*; D013406:Suicide, Attempted
D018492:Dopamine Antagonists; D000639:Amitriptyline; D010546:Perphenazine