New adrenal-scanning agent.
A new adrenal-specific compound, 6beta-iodomethyl-19-norcholest-5(10)-en-3beta-ol(NCL-3-I), which is derived from 19-iodocholesterol (CL-19-I), has been found. Tissue distribution studies have revealed that the rat adrenal gland accumulates ten times more NCL-6-131-I than CL-19-131-I. The advantage of NCL-6-131-I as a possible adrenal-scanning agent is discussed.
D000307:Adrenal Gland Diseases / Q000175:diagnosis*; D000311:Adrenal Glands / Q000378:metabolism; D000818:Animals; D002784:Cholesterol / Q000031:analogs & derivatives* / Q000097:blood / Q000378:metabolism; D007457:Iodine Radioisotopes; D007668:Kidney / Q000378:metabolism; D008099:Liver / Q000378:metabolism; D008168:Lung / Q000378:metabolism; D008297:Male; D011877:Radionuclide Imaging; D051381:Rats; D013154:Spleen / Q000378:metabolism; D013737:Testis / Q000378:metabolism; D013961:Thyroid Gland / Q000378:metabolism
D007457:Iodine Radioisotopes; D002784:Cholesterol