Phagocytic properties of exudative microphages from animals with alloxan diabetes and insulin-induced hypoglycemia.
Phagocytosis was studied in exudative microphages from white mice with alloxan diabetes and insulin-induced hypoglycemia. Peritoneal exudates were induced to obtain exudative forms of microphages, which were used to phagocytize Staphylococcus aureus 209 P Oxford. Phagocytic indices were calculated by the method of Davies. The liver and pancreas were studied morphologically and histochemically, and serum glucose levels were assayed. The experiments showed that: 1) lowered phagocytic indices in animals with alloxan diabetes and insulin-induced hypoglycemia indicate lower phagocytic capability of exudative microphages; 2) normal phagocytosis depends on: a) normal blood levels of glucose as energetic material, and b) adequate concentration of insulin in tissues as enzymatic "transporter" of glucose.
D000496:Alloxan / Q000008:administration & dosage; D000818:Animals; D001786:Blood Glucose / Q000032:analysis; D003921:Diabetes Mellitus, Experimental / Q000276:immunology* / Q000473:pathology; D005122:Exudates and Transudates / Q000166:cytology; D007003:Hypoglycemia / Q000276:immunology* / Q000473:pathology; D007279:Injections, Subcutaneous; D007328:Insulin / Q000008:administration & dosage; D008099:Liver / Q000648:ultrastructure; D008297:Male; D051379:Mice; D010179:Pancreas / Q000648:ultrastructure; D010586:Phagocytes / Q000276:immunology*
D001786:Blood Glucose; D007328:Insulin; D000496:Alloxan