Cell mediated immunity in experimental rubella infections.
Antibody and cell-bound immune response were assessed in rabbits inoculated by the intravenous route with Cenedehill or with wild rubella virus. Our results suggest that wild or attenuated live rubella virus induce a transient unresponsiveness of the lymphocytes to PHA stimulation in vitro and suggest also that this immunosuppression was due to the persistence of rubella virus in the lymphocytes.
D000818:Animals; D000914:Antibodies, Viral / Q000032:analysis; D000917:Antibody Formation; D001769:Blood / Q000382:microbiology; D006385:Hemagglutination Inhibition Tests; D007111:Immunity, Cellular; D007165:Immunosuppression Therapy; D007275:Injections, Intravenous; D037102:Lectins / Q000494:pharmacology; D008213:Lymphocyte Activation; D008214:Lymphocytes / Q000187:drug effects / Q000382:microbiology; D011817:Rabbits; D012409:Rubella / Q000276:immunology*; D012411:Rubella Vaccine; D012412:Rubella virus / Q000276:immunology* / Q000302:isolation & purification; D014613:Vaccines, Attenuated
D000914:Antibodies, Viral; D037102:Lectins; D012411:Rubella Vaccine; D014613:Vaccines, Attenuated