Increased kidney size and glomerular filtration rate in untreated juvenile diabetes: normalization by insulin-treatment.
Glomerular filtration rate (GFR), renal plasma flow (RPF) and roentigenographic kiendy size were measured in six newly diagnosed male diabetics with a mean age of 25 years. Glomerular filtration rate was elevated before treatment to the same extent as found previously. A significant fall in both kidney size and glomerular filtration rate was found after treatment with insulin for 3 months. These results support further the concept that there is a basal connection between enlarged kidneys and the elevated GFR of early diabetes.
D003922:Diabetes Mellitus, Type 1 / Q000188:drug therapy / Q000503:physiopathology*; D003928:Diabetic Nephropathies / Q000188:drug therapy / Q000503:physiopathology*; D005919:Glomerular Filtration Rate; D006801:Humans; D006984:Hypertrophy; D007328:Insulin / Q000627:therapeutic use*; D007668:Kidney / Q000503:physiopathology*; D008297:Male; D012039:Regional Blood Flow / Q000187:drug effects; D014567:Urography
D007328:Insulin