Induction of tumors of the nervous system in the ACI/N rat with 1-butyl-1-nitrosourea administered transplacentally, neonatally, or via maternal milk.
1-Butyl-1-nitrosourea (BNU), a strong leukemogen for rats and mice, was administered prenatally, neonatally, and to sucklings via maternal milk in the ACI/N rats. A high incidence of neurogeneous tumor was obtained in the offspring of the mother rats that received 3 subcutaneous injections of 10 mg/rat of BNU at the late stage of pregnancy and also in the animals that received one subcutaneous injection of 100 mg/kg of BNU within 24 hr after birth. Though in low incidence, the tumors also developed in the offspring of the mothers that received the BNU treatment at the middle stage of their pregnancy or in the rats that were nursed by the mother rats which received 3 subcutaneous injections of 300 mg/kg of BNU during lactation. Contrary to expectations, leukemia developed in only one rat of all the offspring of the mother animals that received the BNU treatment during their pregnancy.
D000818:Animals; D000831:Animals, Newborn; D001932:Brain Neoplasms / Q000139:chemically induced*; D002273:Carcinogens; D005260:Female; D007279:Injections, Subcutaneous; D008297:Male; D008431:Maternal-Fetal Exchange; D009374:Neoplasms, Experimental / Q000139:chemically induced; D009607:Nitrosourea Compounds / Q000008:administration & dosage*; D010524:Peripheral Nervous System Neoplasms / Q000139:chemically induced*; D010911:Pituitary Neoplasms / Q000139:chemically induced; D011247:Pregnancy; D051381:Rats; D011919:Rats, Inbred Strains; D013120:Spinal Cord Neoplasms / Q000139:chemically induced*; D013736:Testicular Neoplasms / Q000139:chemically induced; D013997:Time Factors; D014594:Uterine Neoplasms / Q000139:chemically induced
D002273:Carcinogens; D009607:Nitrosourea Compounds; C002738:N-nitrosobutylurea