Effects of a glucose meal on human pulmonary function at 1600-m and 4300-m altitudes.
The effects of a high-glucose meal on pulmonary function were observed in seven healthy males at medium (1,600 m) and high (4,300 m) altitude. Thirty minutes after the ingestion of 410 kcal (109.9 g cerelose) of glucose, peak serum glucose values were noted with a subsequent decrease over 3 h to below fasting levels at both elevations. At the same time, triglyceride levels continued to decline from 104.2 to 83.3 mg at 1,600 m and 103.7 to 80.5 mg/100 ml at 4,300 m, with differences being significant after 2 h. Both V-E and V-T increased in response to translocation to altitude; however, only V-T increased by 10.9% and 13.3% at 0.5 h for 1,600 m and 4,300 m, respectively. The V-o-2 increased during glucose elevation at 4300 m, while P-A-O2 remained essentially unchanged except for differences associated with translocation to altitude. A 13.9% increase was noted in D-L-CO followign glucose ingestion at 4,300 m along with a decreased triglyceride levels. The elevated D-L-CO values suggest an increase in gas exchange at the alveolar-capillary (A-c) level following the ingestion of a glucose meal for individuals transported to high altitude.
D000328:Adult; D000337:Aerospace Medicine; D000531:Altitude; D000704:Analysis of Variance; D001786:Blood Glucose; D004040:Dietary Carbohydrates / Q000378:metabolism*; D005947:Glucose / Q000378:metabolism*; D006454:Hemoglobins; D006801:Humans; D008168:Lung / Q000502:physiology*; D008297:Male; D014280:Triglycerides / Q000097:blood; D014692:Ventilation-Perfusion Ratio
D001786:Blood Glucose; D004040:Dietary Carbohydrates; D006454:Hemoglobins; D014280:Triglycerides; D005947:Glucose