Arterial-wall tissue factors influencing haemocoagulation, and their release into circulation in endarterectomy.
The wall of lover-limb arteries affected with severe atherosclerosis contains a Complex of substances with pro- and anticoagulative activities. The arterial wall, traumatized in endarterectomy by separation of the individual coats, releases procoagulative substances into blood circulation. The most conspicuous local manifestations of hypercoagulation and hypofibrinolysis appear on the day of surgery. The artery operated upon releases the thromboplastic factor for nine days; substances shortening the thrombin time (antiheparin substance, thrombin accelerator), for five days; and inhibitors of fibrinolysis, for four days after operation. A correlation was found between the regenerative process in the endarterectomized artery and the dynamics of the release of tissue factors influencing the haemocoagulation.
D000818:Animals; D001162:Arteriosclerosis Obliterans / Q000097:blood / Q000601:surgery; D001777:Blood Coagulation; D002404:Catheterization; D004285:Dogs; D004691:Endarterectomy; D005337:Fibrin / Q000032:analysis; D005342:Fibrinolysis; D006801:Humans; D007083:Iliac Artery / Q000601:surgery; D010477:Perfusion; D011183:Postoperative Complications / Q000097:blood; D013917:Thrombin / Q000032:analysis; D013925:Thromboplastin / Q000032:analysis; D013997:Time Factors
D005337:Fibrin; D013925:Thromboplastin; D013917:Thrombin