[Effect of amitriptyline and nortriptyline on the intracular pressure and aqueous humor dynamics in rabbits (author's transl)].
Both amitriptyline and nortriptyline applied conjunctivally produced pupil size enlargement, intraocular pressure decrease and a fall in aqueous humor formation. Phenoxybenzamine and superior cervical sympathetic ganglionectomy prevented the amitriptyline or nortriptyline inducing intraocular pressure changes. Either systemic administered or conjunctivally applied amitriptyline or nortriptyline, potentiated the effects on the pupil and intraocular pressure of exogenously norepinephrine.
D000639:Amitriptyline / Q000494:pharmacology*; D000818:Animals; D001082:Aqueous Humor / Q000187:drug effects*; D004357:Drug Synergism; D005260:Female; D007429:Intraocular Pressure / Q000187:drug effects*; D008297:Male; D009638:Norepinephrine / Q000494:pharmacology; D009661:Nortriptyline / Q000494:pharmacology*; D011680:Pupil / Q000187:drug effects; D011817:Rabbits; D013268:Stimulation, Chemical
D000639:Amitriptyline; D009661:Nortriptyline; D009638:Norepinephrine
Estudio de la acción de la amitriptilina y nortriptilina sobre la presión intraocular y dinámica del humor acuoso en el conejo