Mass spectrometry in structural and stereochemical problems CCXLV. [1] The electron impact induced fragmentation reactions of 17-oxygenated progesterones.
The mass spectral fragmentation of a number of 17alpha-hydroxy-, 17alpha-acetoxy-, and 17alpha-methoxyprogesterones have been examined. Unlike other steroidal delta4-3-ketones, fragmentation reactions associated with the alpha,beta-unsaturated ketonic function are not particularly significant; rather, abundant ions are formed by decomposition processes occurring in and around ring D. Reactions of diagnostic significance include complete or partial loss of ring D, and elimination of the C-17 side chain (CH3CO), followed by loss of the C-17 oxygen function together with a hydrogen atom (H2O, CH3COOH, CH3OH).
D006908:Hydroxyprogesterones / Q000031:analogs & derivatives*; D013058:Mass Spectrometry; D008738:Methyl Ethers; D008968:Molecular Conformation; D010100:Oxygen; D013237:Stereoisomerism
D006908:Hydroxyprogesterones; D008738:Methyl Ethers; D010100:Oxygen