Effects of ethyl adenosine-5'-carboxylate on the heart and coronary circulation.
Using the canine heart-lung preparation supported by a donor, the effects of ehtyl adenosine-5'-carboxylate (EAC) on the heart and coronary circulation were studied and compared with those of adenosine. EAC produced qualitatively similar effects to adenosine in this preparation. Aminophylline inhibited the effects of EAC as well as those of adenosine. Dipyridamole did not potentiate the effects of EAC, while it produced a definite potentiation of the effects of adenosine.
D000241:Adenosine / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D000628:Aminophylline / Q000494:pharmacology; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D002264:Carboxylic Acids / Q000494:pharmacology; D002302:Cardiac Output / Q000187:drug effects; D003326:Coronary Circulation / Q000187:drug effects*; D004176:Dipyridamole / Q000494:pharmacology; D004285:Dogs; D004357:Drug Synergism; D005260:Female; D006339:Heart Rate / Q000187:drug effects; D066298:In Vitro Techniques; D007288:Inosine / Q000494:pharmacology; D008297:Male
D002264:Carboxylic Acids; D000628:Aminophylline; D007288:Inosine; D004176:Dipyridamole; D000241:Adenosine