A murine model for central nervous system leukemia and its possible relevance to human leukemia.
Treatment of a transplantable leukemia in AKR mice with both amphotericin B and 1,3-Bis(2-chloroethyl)-1-nitrosourea cured a significant percentage of animals with advanced disease. Some long-term survivors developed paralysis, and they invariably demonstrated central nervous system (CNS) leukemia. Some of these animals had a systemic relapse of their leukemia, and the CNS appeared to act as a focus for systemic dissemination. The occurrence patterns and histopathologic features of the CNS leukemia in the long-term survivors were strikingly similar to those observed in humans with acute lymphoblastic leukemia.
D000666:Amphotericin B / Q000627:therapeutic use; D000818:Animals; D001921:Brain / Q000473:pathology; D002330:Carmustine / Q000627:therapeutic use; D002493:Central Nervous System Diseases; D004195:Disease Models, Animal; D005260:Female; D007942:Leukemia, Experimental / Q000188:drug therapy / Q000473:pathology; D007945:Leukemia, Lymphoid / Q000188:drug therapy; D008578:Meninges / Q000473:pathology; D051379:Mice; D008806:Mice, Inbred AKR; D009362:Neoplasm Metastasis; D009364:Neoplasm Recurrence, Local; D010243:Paralysis / Q000209:etiology; D013116:Spinal Cord / Q000473:pathology
D000666:Amphotericin B; D002330:Carmustine