Systemic aspirin and indomethacin do not prevent the response of the monkey eye to trauma.
The stability of the blood-aqueous barrier of the monkey eye was challenged by three different methods: anterior chamber paracentesis, intravitreal shigella endotoxin, and subconjunctival arachidonic acid. Systemic aspirin and indomethacin were ineffective in stabilizing the blood-aqueous barrier in all three of these systems.
D000818:Animals; D001082:Aqueous Humor / Q000032:analysis; D001095:Arachidonic Acids; D001241:Aspirin / Q000008:administration & dosage / Q000627:therapeutic use*; D004305:Dose-Response Relationship, Drug; D004731:Endotoxins; D005131:Eye Injuries / Q000503:physiopathology*; D005136:Eye Proteins / Q000378:metabolism*; D007213:Indomethacin / Q000627:therapeutic use*; D007429:Intraocular Pressure / Q000187:drug effects; D008253:Macaca mulatta; D011677:Punctures; D012760:Shigella; D014605:Uveitis / Q000517:prevention & control
D001095:Arachidonic Acids; D004731:Endotoxins; D005136:Eye Proteins; D001241:Aspirin; D007213:Indomethacin