Protective effect of Pepto-Bismol liquid on the gastric mucosa of rats.
Pepto-Bismol liquid (primary active constituent, bismuth subsalicy-late) protected the gastric mucosa of rats against the formation of hemorrhagic lesions or erosions in response to cold + restraint stress, to a combination of aspirin and cold + restraint stress, and to ethyl alcohol. The protective effect of Pepto-Bismol in these studies was clearly demonstrated. Although the mechanism of action of Pepto-Bismol was not delineated, there was a suggestion that the degree of coating of the gastric mucosa was related to protection.
D000818:Animals; D001241:Aspirin / Q000009:adverse effects; D001729:Bismuth / Q000494:pharmacology* / Q000627:therapeutic use; D003080:Cold Temperature / Q000009:adverse effects; D004195:Disease Models, Animal; D000431:Ethanol / Q000009:adverse effects; D005753:Gastric Mucosa / Q000187:drug effects*; D010437:Peptic Ulcer / Q000139:chemically induced / Q000188:drug therapy / Q000517:prevention & control*; D051381:Rats
D000431:Ethanol; D001241:Aspirin; D001729:Bismuth