A transient excited state model for sodium permeability changes in excitable membranes.
In this paper we explore the properties of a mathematical model for the passive sodium permeability system of excitable membranes. This model is distinguished by the explicit inclusion of a rate constant which depends not on instantaneous voltage, but on rate of voltage change. Actually, the model is a rather modest modification of the Hodgkin-Huxley model, but displays some behaviors which the H-H model does not. Among these behaviors are a pronounced inactivation shift (for certain parameter values), a difference between inactivation time constant as measured by turning off a sodium current under sustained depolarization and as measured by double pulse experiments, skip runs under sustained current stimulation, and accommodation to slowing rising currents.
D004553:Electric Conductivity; D007700:Kinetics; D008433:Mathematics; D008566:Membranes; D008956:Models, Chemical; D010539:Permeability; D012964:Sodium
D012964:Sodium