Experimental cerebral vasospasm in cats: modification by a new synthetic vasodilator YC-93.
Effects of a new synthetic vasodilator, YC-93, a derivative of 1. 4-dihydropyridine, on experimental cerebral vasospasm, were studies in cats. A topical administration of YC-93 solution was found to rapidly reverse the spasm of the basilar artery induced with a subarachnoi application of fresh blood, serotonin or porstaglandin F2 alpha. Pretreatment of the basilar artery with YC-93 prevented the development of experimental vasospasm with all these agents.
D000818:Animals; D001488:Basilar Artery; D001769:Blood; D002415:Cats; D003998:Dicarboxylic Acids / Q000627:therapeutic use; D002546:Ischemic Attack, Transient / Q000188:drug therapy* / Q000209:etiology; D009578:Nitrobenzenes / Q000627:therapeutic use; D011453:Prostaglandins; D011725:Pyridines / Q000627:therapeutic use*; D012701:Serotonin; D014665:Vasodilator Agents / Q000627:therapeutic use
D003998:Dicarboxylic Acids; D009578:Nitrobenzenes; D011453:Prostaglandins; D011725:Pyridines; D014665:Vasodilator Agents; D012701:Serotonin