The effects of cosmic Particle radiation on pocket mice aboard Apollo XVII: V. Preflight studies on tolerance of pocket mice to oxygen and heat. Part I. physiological studies.
Tests were carried out on pocket mice to ascertain their tolerance to elevated oxygen pressures alone and to a combination of hyperoxta and heat in excess of that expected during the flight of the mice on Apollo XVII. the mice withstood oxygen partial pressures up to 12 pst at normal room temperature (24 degrees C, 75 degrees F) over a period of 7 days. A few mice previously exposed to increased PO2 died in the course of exposure to an oxygen pressure of 10 pst or 12 psi (517 mm or 620 mm Hg) for 13 d in ambient heat of 32 degrees C (90 degrees F). Supplemental vitamin E and physiological saline loading given prior to exposure had no apparent protective effect. The overall conclusion was that the pocket mice which were to go on Apollo XVII could readily survive the ambient atmosphere to which they would be exposed.
D000222:Adaptation, Physiological; D000818:Animals; D001273:Atmosphere Exposure Chambers; D001274:Atmospheric Pressure; D003359:Cosmic Radiation; D004780:Environment, Controlled; D006358:Hot Temperature; D051379:Mice; D010100:Oxygen; D010313:Partial Pressure; D011830:Radiation Effects; D012965:Sodium Chloride / Q000008:administration & dosage; D013026:Space Flight; D014481:United States; D014810:Vitamin E / Q000494:pharmacology
D014810:Vitamin E; D012965:Sodium Chloride; D010100:Oxygen