[Preliminary results of immuno-surgical treatment of primary melanoma (author's transl)].
During the course of 1973, 14 patients affected by primary skin melanoma were treated with surgery and adjunctive immunotherapy. This comprized preliminary non specific treatment with 2 - 4 di-nitrochlorobenzene (DNCB) followed by wide excision. Pathological examination of melanomas thus treated essentially shows dysruption of tumoral masses by lymphoplasmocytic strands. Significant increase in 19S (IgM) is observed after immunotherapy. Though follow-up perspective is insufficient, all patients following this therapeutic protocole are in apparent complete remission.
D000328:Adult; D000368:Aged; D001323:Autoantibodies / Q000032:analysis; D003601:Cytotoxicity Tests, Immunologic; D004137:Dinitrochlorobenzene / Q000627:therapeutic use; D005260:Female; D006801:Humans; D007111:Immunity, Cellular; D007074:Immunoglobulin G / Q000032:analysis; D007075:Immunoglobulin M / Q000032:analysis; D007167:Immunotherapy; D008214:Lymphocytes / Q000276:immunology; D008297:Male; D008545:Melanoma / Q000276:immunology / Q000473:pathology / Q000601:surgery*; D008875:Middle Aged; D012075:Remission, Spontaneous; D012878:Skin Neoplasms / Q000276:immunology / Q000473:pathology / Q000601:surgery*
D001323:Autoantibodies; D004137:Dinitrochlorobenzene; D007074:Immunoglobulin G; D007075:Immunoglobulin M
Résultants préliminaires du traitement immunochirurgical du mélanome primitif