Polymorphism of red cell glyoxalase I (EI: 4.4.1.5); a new genetic marker in man. Investigation of 169 mother-child combinations.
The polymorphism of glyoxalase I was investigated in 169 mother-child combinations from southwestern Germany. Glyoxalase I (GLO) has 3 common phenotypes: GLO 1, GLO 2-1, and GLO 2. The results are in good agreement with the formal hypothesis: Two alleles GLO1 and GLO2 at an autosomal locus. The GLO1 gene frequency was estimated to be 0.39. From the electrophoretic pattern the GLO-molecule appears to consist of two subunits.
D004912:Erythrocytes / Q000201:enzymology*; D005260:Female; D005787:Gene Frequency; D005860:Germany, West; D005978:Glutathione; D006037:Glyoxal; D006801:Humans; D008190:Lyases; D008967:Molecular Biology; D011110:Polymorphism, Genetic
D006037:Glyoxal; D008190:Lyases; D005978:Glutathione