Induction of hepatitis in adult Syrian hamster by H-1 virus.
The induction of hepatitis in adult hamster by H-1 virus was documented by demonstrating an increase in serum SGOT and SGPT at 3-9 wk postinoculation. The electrophoresis pattern of LDH isoenzymes showed a marked increase in the liver fraction (fraction 5) indicating liver damage in infected hamsters. The pathology displayed in diseased livers revealed a focal degeneration of hepatic cells although infiltration of white cells was not observed. H-1 virus is apparently capable of producing hepatitis (without symptoms) in adult hamsters as well as cause hepatitis and severe cerebral disease in newborn hamsters.
D000410:Alanine Transaminase / Q000097:blood; D000818:Animals; D001219:Aspartate Aminotransferases / Q000097:blood; D006224:Cricetinae; D004591:Electrophoresis, Polyacrylamide Gel; D006520:Hepatitis, Animal / Q000201:enzymology / Q000209:etiology*; D007274:Injections, Intraperitoneal; D007527:Isoenzymes; D007770:L-Lactate Dehydrogenase / Q000097:blood; D008099:Liver / Q000473:pathology; D008854:Microscopy, Electron; D009336:Necrosis; D010321:Parvoviridae / Q000472:pathogenicity*; D013997:Time Factors
D007527:Isoenzymes; D007770:L-Lactate Dehydrogenase; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase