The significance of circulating glycerol as a precursor of pulmonary phosphatidylcholine in the developing mammalian lung.
There is scant information regarding the contribution made by circulating precursors to pulmonary phosphatidylcholine synthesis in the developing mammalian lung. In situ pulmonary artery perfusions were performed in term New Zealand newborn rabbits with physiologic buffer containing either 3.6 mM or 10.8 mM glycerol. There was a twofold increase in nanomoles of glycerol-phosphatidylcholine synthesized at 30 min when the higher concentration of glycerol was used. Continuing with the higher concentration, a near three-fold increase was observed between the 30-min and 60-min perfusions. This data indicates that the de novo synthesis of pulmonary phosphatidylcholine is influenced by the concentration of glycerol in the perfusate as well as the duration of perfusion.
D000818:Animals; D000831:Animals, Newborn; D002021:Buffers / Q000494:pharmacology; D004075:Diglycerides / Q000032:analysis; D005260:Female; D005333:Fetus / Q000032:analysis; D005990:Glycerol / Q000097:blood*; D066298:In Vitro Techniques; D008055:Lipids / Q000096:biosynthesis; D008168:Lung / Q000032:analysis / Q000254:growth & development* / Q000502:physiology; D010477:Perfusion; D010713:Phosphatidylcholines / Q000096:biosynthesis*; D011651:Pulmonary Artery / Q000187:drug effects; D011817:Rabbits
D002021:Buffers; D004075:Diglycerides; D008055:Lipids; D010713:Phosphatidylcholines; D005990:Glycerol