Experimental studies on the pathogenesis and prophylaxis of stroke in stroke-prone spontaneously hypertensive rats (SHR). (2) Prophylactic effect of moderate control of blood pressure on stroke.
The offspring of male stroke-prone SHR, 80 in total, were divided into treated and nontreated groups at the age of 30 to 45 days. The former groups were treated with alpha-methyl dopa (2 g/l in the drinking water), or L-dopa (2 g/l) with or without peripheral decarboxylase inhibitor (MK-486, 1-3 g/l) or apresoline (0.08 g/l) thereafter till they died a natural death during 1  and a half year observation period. So far as hypertension was controlled under about 210 mmHg, no stroke was observed, while nontreated group developed cerebrovascular lesions spontaneously in about 80 per cent. This study experimentally confirmed the importance of blood pressure control for the prevention of stroke.
D000818:Animals; D002230:Carbidopa / Q000627:therapeutic use; D002262:Carboxy-Lyases / Q000037:antagonists & inhibitors; D002561:Cerebrovascular Disorders / Q000209:etiology / Q000517:prevention & control*; D006339:Heart Rate / Q000187:drug effects; D006830:Hydralazine / Q000627:therapeutic use; D006973:Hypertension / Q000150:complications / Q000188:drug therapy* / Q000517:prevention & control; D007980:Levodopa / Q000627:therapeutic use; D008297:Male; D008750:Methyldopa / Q000627:therapeutic use; D051381:Rats
D006830:Hydralazine; D007980:Levodopa; D008750:Methyldopa; D002262:Carboxy-Lyases; D002230:Carbidopa