Effect of guanethidine and of reserpine on angiotensin responsiveness in man.
The respective effects of guanethidine and reserpine on angiotensin responsiveness in man have been investigated. Oral administration of 0.5 mg guanethidine per kg for a week has been found to reduce angiotensin responsiveness considerably, while plasma renin activity remained unaffected. Daily 1 mg reserpine for a week did not influence either angiotensin responsiveness or renin activity. Comparison of the results obtained with the enhancing effect of alphamethyldopa on angiotensin responsiveness has led to the conclusion that there is no relationship between the hypotensive activity of the two drugs in question and their respective effects on angiotensin responsiveness.
D000293:Adolescent; D000328:Adult; D000804:Angiotensin II / Q000494:pharmacology*; D001794:Blood Pressure / Q000187:drug effects; D004347:Drug Interactions; D005260:Female; D006145:Guanethidine / Q000494:pharmacology*; D006801:Humans; D008297:Male; D008750:Methyldopa / Q000494:pharmacology; D008875:Middle Aged; D012083:Renin / Q000097:blood; D012110:Reserpine / Q000494:pharmacology*
D000804:Angiotensin II; D008750:Methyldopa; D012110:Reserpine; D012083:Renin; D006145:Guanethidine