The effect of intravenous prostaglandin F2 alpha and E2 on the motility of the sigmoid colon.
The effect of a 20-min intravenous infusion of prostaglandin E2 (0-08 mug kg-1 min-1) or of prostaglandin F2 alpha (0-8 mug kg-1 min-1) on the segmental pressures in the sigmoid colon was studied in 12 patients. Prostaglandin F2 alpha had no measurable effect, but prostaglandin E2 significantly inhibited sigmoid motility.
D012809:Colon, Sigmoid / Q000187:drug effects*; D003967:Diarrhea / Q000139:chemically induced; D005769:Gastrointestinal Motility / Q000187:drug effects*; D006801:Humans; D007275:Injections, Intravenous; D008297:Male; D008365:Manometry; D011453:Prostaglandins / Q000008:administration & dosage / Q000494:pharmacology*; D012812:Sigmoidoscopy
D011453:Prostaglandins