Cycloalkanones. 7. Hypocholesterolemic activity of aliphatic compounds related to 2,8-dibenzylcyclooctanone.
A series of 19 aliphatic analogs of 2,8-dibenzylcyclooctanone and 1,5-diphenyl-2,4-dimethyl-3-pentanone was examined. Separation of hypocholesterolemic activity from the previously observed uterotropic and antifertility activities was achieved by simplification of the parent compound to 2-octanone. There was no loss of hypocholesterolemic activity. Reduction of serum cholesterol levels in male rats to less than 50% of control values was obtained at a dose of 10 mg/kg/day.
D000818:Animals; D000924:Anticholesteremic Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D001593:Benzyl Compounds / Q000138:chemical synthesis / Q000494:pharmacology; D002784:Cholesterol / Q000097:blood; D003516:Cycloparaffins / Q000138:chemical synthesis* / Q000494:pharmacology; D003864:Depression, Chemical; D005260:Female; D005298:Fertility / Q000187:drug effects; D005327:Fetal Resorption / Q000139:chemically induced; D008297:Male; D051379:Mice; D009929:Organ Size / Q000187:drug effects; D011247:Pregnancy; D051381:Rats; D013268:Stimulation, Chemical; D014599:Uterus / Q000187:drug effects
D000924:Anticholesteremic Agents; D001593:Benzyl Compounds; D003516:Cycloparaffins; D002784:Cholesterol