Control of the malignant hyperpyrexic syndrome in MHS swine by dantrolene sodium.
Experiments are described which demonstrate that dantrolene sodium effectively terminates the syndrome of malignant hyperpyrexia induced in susceptible swine by exposure to halothane. Dantrolene is also shown to block initiation of the syndrome of malignant hyperpyrexia by halothane in MHS swine. Therapeutic use of this drug in patients with anaesthetic-induced malignant hyperpyrexia appears to be indicated.
D000768:Anesthesia, General / Q000009:adverse effects; D000818:Animals; D003620:Dantrolene / Q000627:therapeutic use*; D006221:Halothane / Q000009:adverse effects; D006827:Hydantoins / Q000627:therapeutic use*; D008305:Malignant Hyperthermia / Q000139:chemically induced / Q000188:drug therapy*; D008353:Mannitol; D012964:Sodium; D012972:Sodium Hydroxide; D013552:Swine
D006827:Hydantoins; D008353:Mannitol; D012972:Sodium Hydroxide; D012964:Sodium; D003620:Dantrolene; D006221:Halothane