Familial scoliosis. A clinical report.
Scoliosis appeared in fifteen members of a family in three generations. The eight members examined showed an idiopathic type of scoliosis. Father-to-son transmission occurred more than once. Although at first appearance transmission of the scoliosis is as an autosomal dominant trait, the concept of polygenic inheritance, as has been shown in previous population studies, could also explain the inheritance in this family.
D000293:Adolescent; D000328:Adult; D002170:Canada; D002675:Child, Preschool; D005260:Female; D005799:Genes, Dominant; D006801:Humans; D007557:Israel; D007585:Jews; D008297:Male; D010375:Pedigree; D012600:Scoliosis / Q000235:genetics*