Colorimetric analysis of hexachlorophene in topical formulations.
The commonly used 4-aminoantipyrine dye formation procedure for hexachlorophene analysis in topical formulations was modified to overcome interference due to other components. Bar soaps and nonemulsion formulations are analyzed directly, employing a chloroform back-extraction stage of the dye prior to quantitation. Hexachlorophene in emulsions and liquid soaps is determined using a TLC separation prior to dye formation.
D000641:Ammonia; D000983:Antipyrine / Q000031:analogs & derivatives / Q000032:analysis; D002021:Buffers; D002855:Chromatography, Thin Layer / Q000379:methods; D003124:Colorimetry / Q000379:methods; D004655:Emulsions / Q000032:analysis; D005292:Ferricyanides; D006582:Hexachlorophene / Q000032:analysis*; D009824:Ointments / Q000032:analysis; D012996:Solutions
D002021:Buffers; D004655:Emulsions; D005292:Ferricyanides; D009824:Ointments; D012996:Solutions; D000641:Ammonia; D006582:Hexachlorophene; D000983:Antipyrine