[Peri-osteocytic calcium fixation under calcitonin treatment. Microradiographic study using automatic analysis of images in 8 cases of osteogenesis imperfecta].
The authors treated eight cases of osteogenesis imperfecta using doses of 1 to 2 units of MRC over periods ranging from 6 weeks to 27 months. The lacunar surface area measured before and after treatment was greatly decreased as a result of the latter, probably as the result of marked calcium fixation around the osteocytes, though this effect seems to be transient. The hypothesis of an inactivation of calcitonin on a immunological basis or of a  secondary hyperparathyroid reaction is suggested.
D000293:Adolescent; D001322:Autoanalysis; D001706:Biopsy; D001862:Bone Resorption / Q000473:pathology; D001842:Bone and Bones / Q000378:metabolism* / Q000473:pathology; D002116:Calcitonin / Q000627:therapeutic use*; D002118:Calcium / Q000378:metabolism*; D002648:Child; D002675:Child, Preschool; D006801:Humans; D008297:Male; D008852:Microradiography; D010013:Osteogenesis Imperfecta / Q000188:drug therapy* / Q000378:metabolism
D002116:Calcitonin; D002118:Calcium
Fixation calcique péri-ostéocytaire sous calcitonine. Etude microradiographique à l'analyseur automatique d'images dans huit cas d'ostéogénèse imparfaite