Radiopague contrast media. Part 30. New heterocyclic derivatives of triiodophenoxy alkanoic acids.
A series of new heterocyclic derivatives of triiodophenyl and triiodophenoxy alkanoic acids was prepared; some of these compounds showed high billiary excretion and low acute toxicity in rats. One compound, 2-ethyl-3-[3-N-butyrolactamyl-2,4,6-triiodophenyl]-propionic acid, showed such characteristics that encouraged us to carry out further preclinical and clinical investigations.
D000818:Animals; D002264:Carboxylic Acids / Q000138:chemical synthesis / Q000378:metabolism / Q000633:toxicity; D003287:Contrast Media / Q000138:chemical synthesis* / Q000633:toxicity; D007462:Iodobenzenes / Q000138:chemical synthesis* / Q000378:metabolism / Q000633:toxicity; D007928:Lethal Dose 50; D010647:Phenyl Ethers / Q000138:chemical synthesis / Q000378:metabolism / Q000633:toxicity; D051381:Rats
D002264:Carboxylic Acids; D003287:Contrast Media; D007462:Iodobenzenes; D010647:Phenyl Ethers