[The influence of ethrane on the electro- and pentylenetetrazol-convulsions in mice (author's transl)].
The influence of Ethrane upon electro shock and pentylenetetrazol-induced convulsions was studied in mice. Similar to other inhalation anaesthetics and to barbiturates Ethrane exerts a powerful anticonvulsive activity. There is a dose response relationship between the rate of electro shock (20 mA/0.2 sec) induced convulsions and inspiratory Ethrane concentration, convulsions being completely prevented by 1.5 vol.-percent of Ethrane. The LD(50) of pentylentetrazol increases five fold under a 2 vol.-percent Ethrane anaesthesia.
D000769:Anesthesia, Inhalation; D000777:Anesthetics / Q000009:adverse effects / Q000494:pharmacology*; D000818:Animals; D000927:Anticonvulsants / Q000008:administration & dosage; D002713:Chlorine / Q000008:administration & dosage / Q000009:adverse effects / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D004347:Drug Interactions; D004597:Electroshock; D004987:Ethers / Q000008:administration & dosage / Q000009:adverse effects / Q000494:pharmacology*; D005260:Female; D005461:Fluorine / Q000008:administration & dosage / Q000009:adverse effects / Q000494:pharmacology; D007928:Lethal Dose 50; D051379:Mice; D009120:Muscle Cramp / Q000139:chemically induced*; D009132:Muscles / Q000187:drug effects*; D010433:Pentylenetetrazole; D012640:Seizures / Q000139:chemically induced / Q000188:drug therapy
D000777:Anesthetics; D000927:Anticonvulsants; D004987:Ethers; D005461:Fluorine; D002713:Chlorine; D010433:Pentylenetetrazole
Der Einfluss von Ethrane auf den Elektro- und Pentylentetrazol-Krampf der Maus