The effects of trypsin-degradation products of albumin on the activity of the central nervous system.
The investigations deal with the pharmacological activity of albumin degradation products. The peptides which resulted from 30 min trypsin digestion of human albumin exhibited some kinin-like effects. The peptides given intraperitoneally and intraventricularly revealed a central inhibitory action, the strength of which was similar to kinin effects.
D000418:Albumins / Q000378:metabolism*; D000818:Animals; D001921:Brain / Q000187:drug effects*; D007274:Injections, Intraperitoneal; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D010455:Peptides / Q000008:administration & dosage / Q000494:pharmacology*; D051381:Rats; D013997:Time Factors; D014357:Trypsin / Q000378:metabolism*
D000418:Albumins; D010455:Peptides; D014357:Trypsin