Delta Beta-Thalassaemia in two yugoslavian families.
Members of two Yugoslavian families were found to have delta-beta-thalassaemia. Interaction of beta-thalassaemia with delta-beta-thalassaemia occured in two young children producing a clinical condition which is somewhat less severe than that of homozygous beta-thalassaemia. Results from biosynthetic analyses indicate that the degree of globin chain imbalance in double heterozygotes for beta- and delta-beta-thalassaemia is similar to that in homozygous beta-thalassaemia. Fetal haemoglobin of all heterozygotes contained G-gamma and A-gamma chains in an average ratio of about 2:3 whereas that in the two double heterozygotes had G-gamma and A-gamma chains in a ratio of 3:2.
D000293:Adolescent; D000328:Adult; D002648:Child; D002675:Child, Preschool; D005260:Female; D006454:Hemoglobins / Q000032:analysis; D006579:Heterozygote; D006720:Homozygote; D006801:Humans; D007223:Infant; D008297:Male; D008875:Middle Aged; D010375:Pedigree; D013789:Thalassemia / Q000097:blood / Q000235:genetics*; D015022:Yugoslavia
D006454:Hemoglobins