Teratologic evaluation of delta9-tetrahydrocannabinol in mice, including a review of the literature.
Pregnant CD1 mice received 5, 15, 50, 150 mg/kg/day of delta9-THC in sesame oil on days 6-15 of gestation orally by gavage and were killed about one day before expected delivery. Treatment had no effect on the maternal weight gain, prenatal mortality rate, fetal weight, and the frequency of gross external, internal, and skeletal abnormalities.
D000014:Abnormalities, Drug-Induced / Q000453:epidemiology*; D000818:Animals; D001835:Body Weight / Q000187:drug effects; D002188:Cannabis / Q000009:adverse effects*; D013759:Dronabinol / Q000008:administration & dosage / Q000009:adverse effects*; D005260:Female; D005313:Fetal Death / Q000453:epidemiology; D005333:Fetus / Q000187:drug effects* / Q000502:physiology; D005865:Gestational Age; D006128:Growth / Q000187:drug effects; D051379:Mice; D008815:Mice, Inbred Strains; D011247:Pregnancy
D013759:Dronabinol