[Prophylaxis of acute gastric erosions with vitamin A in the rat (author's transl)].
The protective effect of Vitamin A against stress-induced ulcerations of the gastric mucosa was investigated by the hypoxic stress model of the rat. The incidence of acute mucosal erosions in the main stomach was significantly reduced by intramuscular application of 125 000 - 500 000 U Vitamin A/kg body weight prior to or immediately after the onset of stress. A dosage smaller than that or an application 2 hours after the onset of stress had no influence on the development of the acute mucosal erosions.
D000818:Animals; D005753:Gastric Mucosa; D000860:Hypoxia; D008297:Male; D051381:Rats; D013272:Stomach Diseases / Q000517:prevention & control*; D013276:Stomach Ulcer / Q000209:etiology / Q000517:prevention & control; D013312:Stress, Physiological / Q000150:complications; D013997:Time Factors; D014801:Vitamin A / Q000008:administration & dosage / Q000627:therapeutic use*
D014801:Vitamin A
Zur Prophylaxe akuter Schleimhauterosionen im Rattenmagen mit Vitamin A