1-methyl-4piperidyl-bis (P-chlorophenoxy) acetate: a new hypolipidemic peroxisome proliferator.
Administration of 1-methyl-4-piperidyl-bis(p-chlorophenoxy) acetate (SaH 42-348) at a dietary concentration of 0.15% for 3 weeks, increased the activity of catalase in both liver and kidney of male wild type (Cs-a strain) mice. A marked increase in the activity of short chain carnitine acyltransferase in the liver was also noted. By electron microscopy, a remarkable increase in the number of peroxisomes (microbodies) was noted in the liver cells. A mild to moderate increase in number of peroxisomes in proximal convoluted tubular epithelium of the kidney was also seen. These studies demonstrate that SaH 42-348 is a potent hepatic peroxisome proliferator.
D000818:Animals; D002333:Carnitine Acyltransferases / Q000378:metabolism; D002374:Catalase / Q000378:metabolism; D006016:Glycolates / Q000494:pharmacology*; D007668:Kidney / Q000201:enzymology; D008055:Lipids / Q000037:antagonists & inhibitors*; D008099:Liver / Q000166:cytology / Q000201:enzymology / Q000648:ultrastructure; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D008830:Microbodies / Q000187:drug effects*; D009940:Organoids / Q000187:drug effects*
D006016:Glycolates; D008055:Lipids; D002374:Catalase; D002333:Carnitine Acyltransferases