Effects of alpha-chlorohydrin on the testes and epididymides of dog: a preliminary study.
Chronic administration of alpha-chlorohydrin (8 mg/kg for 30 days, caused lesions in the testis of dog. Seminiferous tubules presented marked degenerative changes. Leydig cell hypertrophy was conspicous. Epididymal epithelium was regressed and the lumen was devoid of spermatozoa. Obstruction of the epididymal lumen was not seen. Alpha-Chlorohydrin inhibited the synthesis of RNA and sialic acid in the testis, caput epidiymis, corpus epididymis, and cauda epididymis. The total cholesterol per gram of testis was increased significantly after alpha-chlorohydrin administration. The anti-androgenic nature of alpha-chlorohydrin is suggested.
D000818:Animals; D002728:Chlorohydrins / Q000494:pharmacology*; D004285:Dogs; D004822:Epididymis / Q000187:drug effects* / Q000473:pathology; D008297:Male; D009929:Organ Size; D012671:Seminiferous Tubules / Q000473:pathology; D013091:Spermatogenesis / Q000187:drug effects; D013094:Spermatozoa / Q000187:drug effects; D013737:Testis / Q000187:drug effects* / Q000473:pathology; D013997:Time Factors; D000517:alpha-Chlorohydrin / Q000008:administration & dosage / Q000494:pharmacology*
D002728:Chlorohydrins; D000517:alpha-Chlorohydrin