Two cases of pseudoaldosteronism (Liddle's syndrome) in siblings.
Two cases of Liddle's syndrome were found in a brother and sister.  Both showed typical hypokalemic hypertension without hyperaldosteronism.  These cases showed similar responses in various pharmacological tests and their symptoms of hypokalemic and hypertension were relieved by triamterene.  And in a family survey, the father appeared to be affected.  This seems to be the first report on this syndrome in Japan.
D000293:Adolescent; D001794:Blood Pressure; D003907:Dexamethasone / Q000627:therapeutic use; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D006929:Hyperaldosteronism / Q000175:diagnosis / Q000188:drug therapy / Q000235:genetics*; D006973:Hypertension / Q000150:complications; D007008:Hypokalemia / Q000150:complications; D008297:Male; D010375:Pedigree; D013148:Spironolactone / Q000627:therapeutic use; D014223:Triamterene / Q000627:therapeutic use
D013148:Spironolactone; D003907:Dexamethasone; D014223:Triamterene