Effects of methamphetamine on the isolated rat phrenic nerve-diaphragm preparation.
Low concentrations of methamphetamine facilitated twitch, while higher concentrations produced dose-dependent blockade of twitch indirectly elicited. Methamphetamine facilitated twitch elicited by direct stimulation; These findings suggest that methamphetamine-induced enhancement in physical endurance and performance in moderate doses, and muscle weakness at high doses, may be attributed to drug effects at a peripheral site of action.
D000818:Animals; D003964:Diaphragm / Q000187:drug effects; D004558:Electric Stimulation; D066298:In Vitro Techniques; D008297:Male; D008694:Methamphetamine / Q000494:pharmacology*; D009119:Muscle Contraction / Q000187:drug effects*; D009469:Neuromuscular Junction / Q000187:drug effects*; D010791:Phrenic Nerve / Q000187:drug effects* / Q000502:physiology; D051381:Rats; D013618:Tachyphylaxis
D008694:Methamphetamine