Indomethacin release from silicone rubber: a suggested method for continuous inhibition of prostaglandin synthesis.
Indomethacin was vulcanized in dimethylpolysiloxane, an inert silicone suitable for tissue implantation. The drug is released from this polymer matrix gradually in amounts that can inhibit endogenous prostaglandin synthesis. The method is simple, rapid and inexpensive and eliminates repetitive administration in studies where prolonged inhibition of prostaglandin synthesis is desired.
D003692:Delayed-Action Preparations; D003864:Depression, Chemical; D004343:Drug Implants; D007213:Indomethacin / Q000008:administration & dosage* / Q000494:pharmacology; D007700:Kinetics; D008722:Methods; D011453:Prostaglandins / Q000096:biosynthesis*; D012826:Silicone Elastomers
D003692:Delayed-Action Preparations; D004343:Drug Implants; D011453:Prostaglandins; D012826:Silicone Elastomers; D007213:Indomethacin