Dissolution profile in relation to initial particle distribution.
A general equation was derived describing the complete and exact dissolution profile of powders under sink conditions. It is applicable to powders having any initial particle-size distribution, with particles dissolving according to any explicit equation. It was applied to develop an equation for the dissolution of log-normal powders that is more generally applicable than previous approaches. The effect of change in initial particle-size distribution parameters on the dissolution profile is illustrated.
D003201:Computers; D008962:Models, Theoretical; D010316:Particle Size; D011208:Powders; D012995:Solubility
D011208:Powders