3,4-Dihydro-1H-1,4-oxazino[4,3-a]indoles as potential antidepressants.
A series of 3,4-dihydro-1H-1,4-oxazino[4,3-a]indoles bearing basic side chains has been synthesized by a novel chemical process. These compounds have been screened for potential antidepressant activity. One of these derivatives, 3,4-dihydro-1,10-dimethyl-1-(3-methylaminopropyl)-1H-1,4-oxazino[4,3-a]indole (AY-23,673), was particularly potent in the prevention of reserpine ptosis test in mice, with an ED50 of 0.5 mg/kg ip.
D000818:Animals; D000928:Antidepressive Agents / Q000138:chemical synthesis* / Q000494:pharmacology / Q000633:toxicity; D001763:Blepharoptosis / Q000517:prevention & control; D007211:Indoles / Q000138:chemical synthesis* / Q000494:pharmacology / Q000633:toxicity; D007928:Lethal Dose 50; D051379:Mice; D010078:Oxazines / Q000138:chemical synthesis / Q000494:pharmacology / Q000633:toxicity; D012110:Reserpine / Q000037:antagonists & inhibitors
D000928:Antidepressive Agents; D007211:Indoles; D010078:Oxazines; D012110:Reserpine