Assessment of possible luteolytic effect on intra-ovarian injection of prostaglandin F-2ALPHA in the human.
A group of five patients awaiting laparoscopic tubal diathermy were followed by daily assay of luteinising hormone (LH) and progesterone. Between five and eight days after the LH peak, prostaglandin F-2ALPHA (PGF-2ALPHA) was injected into either the corpus luteum or the ovarian stroma. Doses of 100 mu-g into the corpus tuteum, 1000 mu-g into the adjacent stroma and 500 mu-g into an indeterminate ovarian structure had no effect on peripheral plasma progesterone levels or uterine bleeding. An injection of 500 mu-g or 1000 mu-g given unequivocally into the corpus luteum produced a rapid and profound fall in plasma progesterone levels, the nadir coinciding with the onset of uterine bleeding which commenced 24 hours after the injection and persisted for more than seven days. Injection of 100 mu-g in the same volume of saline had no such effect. Despite continued bleeding plasma progesterone levels returned to normal luteal levels for three days and then fell again.
D003338:Corpus Luteum / Q000187:drug effects; D003864:Depression, Chemical; D005260:Female; D006801:Humans; D007986:Luteinizing Hormone / Q000097:blood*; D010053:Ovary / Q000187:drug effects*; D011374:Progesterone / Q000097:blood*; D011460:Prostaglandins F / Q000494:pharmacology*; D013268:Stimulation, Chemical
D011460:Prostaglandins F; D011374:Progesterone; D007986:Luteinizing Hormone