Oxygenation properties of hemoglobin variants with substitutions near the polyphosphate binding site.
Two hemoglobin variants with substitutions at beta 79 and beta 80 were found to have an increased oxygen affinity, but a normal response to organic phosphates. These observations are interpreted in terms of salt bridges which are affected by the substitutions.
D000595:Amino Acid Sequence; D001665:Binding Sites; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D002712:Chlorides / Q000494:pharmacology; D004163:Diphosphoglyceric Acids / Q000378:metabolism / Q000494:pharmacology; D006455:Hemoglobins, Abnormal / Q000378:metabolism*; D008024:Ligands; D009943:Organophosphorus Compounds / Q000494:pharmacology; D010100:Oxygen / Q000097:blood*
D002712:Chlorides; D004163:Diphosphoglyceric Acids; D006455:Hemoglobins, Abnormal; D008024:Ligands; D009943:Organophosphorus Compounds; D010100:Oxygen