Carcinogenic action of quinoxaline 1,4-dioxide in rats.
Quinoxaline 1,4-dioxide was fed to 400 rats at levels of 10 mg or 1 mg/kg body weight for 18 months. It produced a high incidence of nasal and liver tumors only in the group fed 10 mg/kg. Of diverse histologies, the nasal tumors included anaplastic carcinomas, adenocarcinomas, squamous cell carcinomas, neuroepitheliomas, basal cell carcinomas, and a single fibrosarcoma. The nasal epithelium not involved in the neoplastic process showed dysplasia and hyperplasia.
D000230:Adenocarcinoma / Q000139:chemically induced / Q000473:pathology; D000818:Animals; D002273:Carcinogens; D002280:Basal Cell Carcinoma / Q000139:chemically induced / Q000473:pathology; D002294:Carcinoma, Squamous Cell / Q000139:chemically induced / Q000473:pathology; D004305:Dose-Response Relationship, Drug; D005260:Female; D005354:Fibrosarcoma / Q000139:chemically induced / Q000473:pathology; D006965:Hyperplasia / Q000139:chemically induced; D007680:Kidney Neoplasms / Q000139:chemically induced; D008113:Liver Neoplasms / Q000139:chemically induced; D008297:Male; D009374:Neoplasms, Experimental; D018241:Neuroectodermal Tumors, Primitive, Peripheral / Q000139:chemically induced / Q000473:pathology; D009669:Nose Neoplasms / Q000139:chemically induced*; D011230:Precancerous Conditions / Q000139:chemically induced / Q000473:pathology; D011810:Quinoxalines / Q000008:administration & dosage / Q000633:toxicity*; D051381:Rats; D012737:Sex Factors
D002273:Carcinogens; D011810:Quinoxalines