Contraction of the canine gallbladder in different degrees of common bile duct obstruction.
C-terminal octapeptide of cholecystokinin was administered at six dose levels, 4-128 ng/kg, by 184 intravenous injections to three mongrel dogs under several pressure conditions of the biliary system. Gallbladder contraction was monitored radiographically. A good, dose-dependent contraction response resulted with intraductal pressures of 0 and 10 cm water. At 20 cm water, a markedly reduced and dose-independent response occurred. No contraction response was found with an intraductal pressure of 30 cm water. This animal experimental work suggests that in man, a contraction response of 30% or more may rule out significant common bile duct obstruction.
D000818:Animals; D001660:Biliary Tract Diseases / Q000503:physiopathology; D002404:Catheterization; D002758:Cholangiography; D002765:Cholecystography; D002766:Cholecystokinin / Q000494:pharmacology; D002779:Cholestasis / Q000000981:diagnostic imaging; D003135:Common Bile Duct / Q000503:physiopathology; D003937:Diagnosis, Differential; D004285:Dogs; D005704:Gallbladder / Q000187:drug effects / Q000503:physiopathology*; D007275:Injections, Intravenous; D007565:Jaundice / Q000000981:diagnostic imaging / Q000503:physiopathology*; D011312:Pressure
D002766:Cholecystokinin