Analgesic activity of substituted benzylidinohydrazines.
Sixteen substitued benzylidinohydrazines were evaluated for morphine-like analgesic activity by mouse tail-pinch test while aconitine-induced writhing test in mice was used to determine their ability to possess aspirin-like analgesia. All benzylidinohydrazines exhibited analgesic activity where protection against tail-pinch and aconitine-induced writhing response ranged from 16.7-83.3% and 16.7-66.7%, respectively.
D031841:Aconitum / Q000037:antagonists & inhibitors; D000700:Analgesics; D000818:Animals; D001593:Benzyl Compounds / Q000494:pharmacology*; D005260:Female; D006834:Hydrazines / Q000494:pharmacology*; D008297:Male; D051379:Mice; D011930:Reaction Time / Q000187:drug effects; D013035:Spasm / Q000139:chemically induced
D000700:Analgesics; D001593:Benzyl Compounds; D006834:Hydrazines