Metabolic fate of ethynodiol diacetate in the baboon.
The enterohepatic circulation and metabolism of ethynodiol diacetate (3beta,17beta-diacetoxy-17alpha-ethynyl-estr-4-ene) in baboons were studied following the intravenous injection of this contraceptive steroid labeled with 14C (4-position) and with 3H (in either the 3- or 17-acetoxy moieties). Bile and urine from four baboons with biliary fistulas and urine from four intact baboons were collected for 7 hours. On the average, 40% and 44% of the injected dose were excreted in the bile and urine, respectively. Only 48% was recovered in the urine of intact baboons. Analysis of these excretion rates indicates an insignificant enterohepatic circulation of this compound. The steroid was excreted mostly (over 80%) as a glucosiduronate in urine and bile. Very little excretion of the 3-acetoxy compound was detected in the urine or bile at any time interval. 17-Monoacetoxy compounds, however, were detected both in urine and bile, suggesting a difference in the rate of in vivo hydrolysis of the 17beta- vs. the 3beta-acetate.
D000818:Animals; D001646:Bile / Q000378:metabolism; D001658:Biliary Fistula / Q000378:metabolism; D002850:Chromatography, Gel; D002852:Chromatography, Ion Exchange; D004305:Dose-Response Relationship, Drug; D005040:Ethynodiol Diacetate / Q000378:metabolism*; D005965:Glucuronates / Q000378:metabolism / Q000652:urine; D008297:Male; D010215:Papio; D013431:Sulfates / Q000378:metabolism / Q000652:urine; D013997:Time Factors
D005965:Glucuronates; D013431:Sulfates; D005040:Ethynodiol Diacetate