Studies on the effect of penicillin, streptomycin and isonicotinic acid hydrazide on small intestinal oligosaccharidase.
Studies have been done on the effect of Penicillin, Streptomycin and Isonicotinic Acid hydrazide on small intestinal oligosaccharidase and it was observed that the drug penicillin inhibited the enzyme lactase and sucrase by 62.7% and 34.7% respectively, whereas I.N.H. inhibited the enzyme sucrase and maltase by 57.1% and 56.14% respectively. Streptomycin did not show any inhibitory effect on those enzymes. Lactose tolerance test showed impairment of lactose absorption in case of penicillin. Fasting serum sugar level was diminished both in penicillin and streptomycin and the absorption capacity was increased after oral administration of streptomycin.
D000818:Animals; D001786:Blood Glucose / Q000032:analysis; D003864:Depression, Chemical; D004186:Disaccharidases / Q000037:antagonists & inhibitors*; D005696:Galactosidases / Q000037:antagonists & inhibitors; D005959:Glucosidases / Q000037:antagonists & inhibitors; D007408:Intestinal Absorption / Q000187:drug effects; D007421:Intestine, Small / Q000201:enzymology* / Q000378:metabolism; D007538:Isoniazid / Q000494:pharmacology*; D007785:Lactose / Q000378:metabolism; D008297:Male; D010406:Penicillins / Q000494:pharmacology*; D011817:Rabbits; D051381:Rats; D013307:Streptomycin / Q000494:pharmacology*; D013393:Sucrase / Q000037:antagonists & inhibitors
D001786:Blood Glucose; D010406:Penicillins; D004186:Disaccharidases; D005696:Galactosidases; D005959:Glucosidases; D013393:Sucrase; D007785:Lactose; D007538:Isoniazid; D013307:Streptomycin