Comparison of 3,4-dimethoxyphenylethylamine treated plasma from chronic schizophrenics and controls.
Plasma samples were collected from chronic schizophrenic patients not on drug therapy and from non-psychotic hospital volunteet controls and incubated with 3,4-dimethoxywhenylethylamine (DMPEA) when injected into monoamine oxidase inhibitor (MAOI) pretreated mice who were then aggregated (groups of 5 ea.) for four hours, the two kinds of plasma produced results so similar that no differences between them could be observed. Doubling the amount of plasma and DMPEA likewise failed to differentiate plasma origin. In our hands no differentiation between plasma samples from control subjects and schizophrenic patients could be determined under the conditions employed.
D000661:Amphetamine; D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects; D001679:Biogenic Amines / Q000378:metabolism; D001769:Blood / Q000187:drug effects*; D001923:Brain Chemistry / Q000187:drug effects; D002908:Chronic Disease; D003441:Crowding; D004118:Dimethoxyphenylethylamine / Q000494:pharmacology*; D005260:Female; D006801:Humans; D008297:Male; D051379:Mice; D008996:Monoamine Oxidase Inhibitors / Q000494:pharmacology; D009043:Motor Activity / Q000187:drug effects; D010627:Phenethylamines / Q000494:pharmacology*; D012559:Schizophrenia / Q000097:blood*; D013239:Stereotyped Behavior / Q000187:drug effects
D001679:Biogenic Amines; D004118:Dimethoxyphenylethylamine; D008996:Monoamine Oxidase Inhibitors; D010627:Phenethylamines; D000661:Amphetamine