The evaluation of cotton twine as a new anti-inflammatory assay.
A new anti-inflammatory assay is described, utilizing a subcutaneously implanted elongated section of cotton twine to induce granuloma in rats. The cotton twine irritant is easily introduced under the abdominal skin and after seven days a well formed granuloma is established. The procedure works effectively for both steroidal and non-steroidal anti-inflammatory drug evaluation. Consistency of the cotton twine eliminates individual weighing of each section and uniformity in compactness affords reproducible results.
D000818:Animals; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use*; D004343:Drug Implants; D003368:Gossypium; D006099:Granuloma / Q000209:etiology; D007249:Inflammation / Q000188:drug therapy* / Q000209:etiology; D008297:Male; D008722:Methods; D051381:Rats
D000893:Anti-Inflammatory Agents; D004343:Drug Implants