Effects of Cannabis extract on the response of accessory sex organs of adult male mice to testosterone.
Cannabis extract caused a marked reduction in the body weight and in the weights of seminal vesicles, ventral prostate, epididymis, preputial gland and perineal complex (Penis and its bulb and levator ani muscle) of castrated adult male mice. Cannabis extract administration in combination with testosterone propionate (TP) inhibited growth stimulation produced by TP alone. Anti-androgenic nature of the compound is suggested.
D000311:Adrenal Glands / Q000187:drug effects; D000818:Animals; D001835:Body Weight / Q000187:drug effects; D002188:Cannabis / Q000494:pharmacology*; D005837:Genitalia, Male / Q000187:drug effects*; D008297:Male; D051379:Mice; D009929:Organ Size / Q000187:drug effects; D013739:Testosterone / Q000037:antagonists & inhibitors*; D013950:Thymus Gland / Q000187:drug effects; D013961:Thyroid Gland / Q000187:drug effects
D013739:Testosterone