Blood coagulation profile in Indian patients with pre-eclampsia and eclampsia.
Twelve Indian patients with pre-eclampsia, 15 with eclampsia and 15 with normal pregnancy in the third trimester were investigated. A systemic bleeding diathesis was encountered in two patients with eclampsia and in none with pre-eclampsia; two patients with pre-eclampsia, however, had excessive uterine haemorrhage. Coagulation studies showed statistically significant prolongation of thrombin time, elevation of serum fibrinogen degradation products (FDP) and hypofibrinogenaemia in patients with pre-eclampsia as well as eclampsia. In patients with eclampsia, significant thrombocytopenia also occurred. Euglobulin lysis time showed no significant change in patients with pre-eclampsia and eclampsia. There was no significant difference in the coagulation profile between patients with eclampsia and pre-eclampsia, except for more hypofibrinogenaemia in the former. The laboratory findings suggest the occurrence of intravascular coagulation in patients with pre-eclampsia and eclampsia.
D000328:Adult; D000419:Albuminuria / Q000209:etiology; D001777:Blood Coagulation; D001778:Blood Coagulation Disorders / Q000150:complications; D001792:Blood Platelets; D004461:Eclampsia / Q000097:blood* / Q000150:complications; D004487:Edema / Q000209:etiology; D005260:Female; D005340:Fibrinogen / Q000032:analysis; D006474:Hemorrhagic Disorders / Q000150:complications; D006801:Humans; D006973:Hypertension / Q000209:etiology; D007194:India; D007616:Kaolin; D008875:Middle Aged; D010714:Phosphatidylethanolamines; D011225:Pre-Eclampsia / Q000097:blood* / Q000150:complications; D011247:Pregnancy; D011263:Pregnancy Trimester, Third; D011517:Prothrombin Time; D012712:Serum Globulins; D013921:Thrombocytopenia / Q000150:complications; D014592:Uterine Hemorrhage / Q000150:complications
D010714:Phosphatidylethanolamines; D012712:Serum Globulins; D007616:Kaolin; D005340:Fibrinogen