Effect of trimethoprim-sulfamethoxazole on blood insulin and glucose concentrations of diabetics.
Trimethoprim-sulfamethoxazole (TMP-SMX) caused no significant changes in the blood glucose or insulin concentrations of diabetic subjects treated by dietary measures alone or by insulin and diet. In only one of eight subjects receiving oral hypoglycemic agents for the control of diabetes did a significant immediate increase in immunoreactive insulin follow administration of TMP-SMX. In the same patient hypoglycemic symptoms were present after the agent had been taken for 14 days.
D000284:Administration, Oral; D001786:Blood Glucose; D003920:Diabetes Mellitus / Q000097:blood* / Q000178:diet therapy / Q000188:drug therapy; D004338:Drug Combinations; D006801:Humans; D007004:Hypoglycemic Agents / Q000009:adverse effects / Q000627:therapeutic use; D007328:Insulin / Q000097:blood* / Q000627:therapeutic use; D013420:Sulfamethoxazole / Q000008:administration & dosage / Q000009:adverse effects*; D014295:Trimethoprim / Q000008:administration & dosage / Q000009:adverse effects*
D001786:Blood Glucose; D004338:Drug Combinations; D007004:Hypoglycemic Agents; D007328:Insulin; D014295:Trimethoprim; D013420:Sulfamethoxazole