[Cerebral complications (viral encephalopathy, toxoplasmosis) in two patients with treated Hodgkin's disease. Clinical and pathological study (author's transl)].
In his anatomo-clinical description of two cases of Hodgkin's disease treated by immunosuppressive agents and which were complicated by encephalopathy, the author insists on the moderate encephalic inflammatory reaction which he attributes, in part, to the noxious effects of this type of therapeutics on the immune defenses. He further reviews similar case histories from the literature and compares them with his personal observations. The first case, of subacute evolution, may have been infected by two distinct viruses represented by intranuclear inclusions; one having its site within the neurons provoking a moderate localized oedematous zone in the cerebral trunk, the other situated within the neuroglia cells results in a net tissular reaction. In the absence of virological and electron microscopic studies it is impossible to be precise about their true nature. The second case, on the contrary of acute evolution, revealed an extraordinary quantity of intracellular toxoplasma parasites in the periphery of several necrotic areas.
D000328:Adult; D001344:Autopsy; D001927:Brain Diseases / Q000473:pathology; D002540:Cerebral Cortex / Q000473:pathology; D003342:Corpus Striatum / Q000473:pathology; D004660:Encephalitis / Q000139:chemically induced* / Q000175:diagnosis / Q000473:pathology; D004827:Epilepsy / Q000150:complications; D005260:Female; D005625:Frontal Lobe / Q000473:pathology; D006429:Hemiplegia / Q000209:etiology; D006689:Hodgkin Disease / Q000188:drug therapy*; D006801:Humans; D007166:Immunosuppressive Agents / Q000009:adverse effects* / Q000627:therapeutic use; D008526:Medulla Oblongata / Q000473:pathology; D009336:Necrosis; D013702:Temporal Lobe / Q000473:pathology; D014122:Toxoplasma / Q000302:isolation & purification; D014123:Toxoplasmosis / Q000139:chemically induced* / Q000473:pathology
D007166:Immunosuppressive Agents
Complications cérébrales (neurovirose, toxoplasmose) de deux cas de maladie de Hodgkin sous traitement immunodeépresseur. Etude anatomo-clinique