The analysis of cardiovascular action of 10-(3-dimethylaminopropyl)-7-chlorobenzo-(b)-(1,8)-naphthyridone-5 monohydrochloride (IF-C-45) with antidepressant properties.
The effects on cardiovascular system of a new compound, 10-(3-dimethylaminopropyl)-7-chlorobenzo-(b)-(1,8)-naphthyridone-5-monohydrochloride (IF-C-45) were investigated in rats, dogs and cats and compared to the effects induced by imipramine. Within the range of the analysis of peripheral cardiovascular effects IF-C-45 acts in a similar way as imipramine does. Its hypotensive and cardiodepressive action is significantly weaker than that of imipramine.
D000284:Administration, Oral; D000818:Animals; D000928:Antidepressive Agents / Q000008:administration & dosage / Q000494:pharmacology*; D001341:Autonomic Nervous System / Q000187:drug effects; D001794:Blood Pressure / Q000187:drug effects; D001808:Blood Vessels / Q000187:drug effects; D002319:Cardiovascular System / Q000187:drug effects*; D002415:Cats; D004123:Dimethylamines / Q000494:pharmacology; D004285:Dogs; D006339:Heart Rate / Q000187:drug effects; D007099:Imipramine / Q000494:pharmacology; D007275:Injections, Intravenous; D051379:Mice; D009130:Muscle, Smooth / Q000187:drug effects; D009287:Naphthyridines / Q000008:administration & dosage / Q000494:pharmacology*; D051381:Rats; D011941:Receptors, Adrenergic; D011950:Receptors, Cholinergic
D000928:Antidepressive Agents; D004123:Dimethylamines; D009287:Naphthyridines; D011941:Receptors, Adrenergic; D011950:Receptors, Cholinergic; D007099:Imipramine