Haemostatic plug formation and stability in the rabbit mesentery after femoral fracture.
The effect of standardised trauma (femoral fracture) on the formation time and stability of haemostatic plugs in transected microvessels of the rabbit mesentery was studied in relation to alterations in fibrinogen concentration, platelet count, platelet adhesiveness, and haematocrit. In contrast to most other studies, platelet adhesiveness as a percentage was found to decrease post-traumatically. One week after trauma, the haemostatic plugs were maximally stable and at the same time venular haemostatic plug formation time was significantly reduced. These findings coincide with high levels of fibrinogen and increased numbers of circulating adhesive platelets.
D000818:Animals; D001772:Blood Cell Count; D001777:Blood Coagulation; D005260:Female; D005264:Femoral Fractures / Q000097:blood*; D005340:Fibrinogen / Q000378:metabolism; D006400:Hematocrit; D006487:Hemostasis; D008297:Male; D008638:Mesenteric Arteries; D008642:Mesenteric Veins; D008833:Microcirculation; D010973:Platelet Adhesiveness; D011817:Rabbits
D005340:Fibrinogen