Synthesis and antiinflammatory activity of some-2-substituted alpha-methyl-5-benzimidazoleacetic acids.
The synthesis of alpha-methyl-5-benzimidazoleacetic acid (17), its 2-amino, 2-phenyl, 2-(4-chlorophenyl), and 2-(4-chlorophenyl)-1-methyl derivatives (18,4,3, and 5, respectively), and alpha-methyl-2-oxo-2,3-dihydro-5-benzimidazoleacetic acid (19) is described.  None of the compounds were effective in reducing carrageenan-induced edema in rat paws.
D000085:Acetates / Q000138:chemical synthesis / Q000627:therapeutic use; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000138:chemical synthesis*; D001562:Benzimidazoles / Q000138:chemical synthesis* / Q000627:therapeutic use; D004487:Edema / Q000188:drug therapy; D008968:Molecular Conformation; D051381:Rats; D013329:Structure-Activity Relationship
D000085:Acetates; D000893:Anti-Inflammatory Agents; D001562:Benzimidazoles