Studies in burns. XIII. Effects of a topical lipid on burned subjects and their wounds.
We evaluated ethyl linoleate (ethyl, (9, 12)-cic, cis-octadecadienoate), a naturally occurring cutaneous water-holding lipid, for its water-holding metabolic, healing and toxic properties in groups of unburned and burned rabbits and its toxic potentials in this species and mice. The lipid appears to reduce evaporative water loss in full-thickness burned rabbits. Associated with this effect is a proportional and related lowering of metabolic heat production. The topical application of the lipid at any time after burn appears to be associated with a significant healing in lesions that, histologically at least, would be interpreted as fullthickness. The material is highly toxic if applied daily to mice or rabbits. The details of the toxic effect (s) are being studied. The commerical-grade material (75 percent pure) contains a derivative of ricinoleci acid and chronic exposure of the EL to air may result in the formation of peroxides and epoxides. These materials exert well-defined toxicity. The obvious potential uses of this agent in treating human burn lesions need not be emphasized, but it does need to be stated categorically that, at present, (Feb 1974), the toxicity has not been defined enough for use except in experiments.
D000287:Administration, Topical; D000336:Aerosols; D000818:Animals; D001706:Biopsy; D001831:Body Temperature / Q000187:drug effects; D001835:Body Weight / Q000187:drug effects; D002056:Burns / Q000188:drug therapy* / Q000382:microbiology / Q000473:pathology; D002151:Calorimetry; D002245:Carbon Dioxide / Q000096:biosynthesis; D006358:Hot Temperature; D006801:Humans; D008041:Linoleic Acids / Q000008:administration & dosage* / Q000494:pharmacology / Q000627:therapeutic use; D008297:Male; D051379:Mice; D010101:Oxygen Consumption / Q000187:drug effects; D011817:Rabbits; D013997:Time Factors; D014867:Water / Q000378:metabolism; D014945:Wound Healing / Q000187:drug effects
D000336:Aerosols; D008041:Linoleic Acids; D014867:Water; D002245:Carbon Dioxide