Correlation between resistance to actinomycin D, karyology, agglutination by concanavalin A and tumorigenicity in Chinese hamster hybrid cells.
Subclones isolated from a Chinese hamster hybrid line, derived from fusion of an actinomycin D-resistant and an actinomycin D-sensitive strain, were studied with respect to their resistance to actinomycin D, karyology, transplantability and agglutination by concanavalin A. Statistical analysis of the results allowed the establishment of a classification of the strains based on increasing resistance to actinomycin D. There appeared to be an inverse correlation between actinomycin D-resistance and tumorigenicity and a positive correlation between this resistance and the presence of a marker chromosome.
D000372:Agglutination Tests; D000818:Animals; D002471:Cell Transformation, Neoplastic; D002875:Chromosomes / Q000032:analysis; D002999:Clone Cells; D003208:Concanavalin A / Q000494:pharmacology*; D006224:Cricetinae; D003609:Dactinomycin / Q000032:analysis / Q000494:pharmacology*; D006822:Hybrid Cells; D006824:Hybridization, Genetic; D007111:Immunity, Cellular; D007621:Karyotyping; D009368:Neoplasm Transplantation; D009374:Neoplasms, Experimental
D003208:Concanavalin A; D003609:Dactinomycin