Inhibition of hamster cell transformation and of benz(a)pyrene hydroxylation by antioxidants.
Addition of butylated hydroxyanisole (BHA) and butylated hydroxytoluene (bht) to benz(a)pyrene (BP) exposed cell cultures results in slight reduction of transformation. The benz(a)pyrene hydroxylation is reduced when antioxidants are added to the incubation mixture.
D000818:Animals; D000840:Anisoles / Q000494:pharmacology*; D001580:Benzopyrenes / Q000494:pharmacology*; D002083:Butylated Hydroxyanisole / Q000494:pharmacology*; D002084:Butylated Hydroxytoluene / Q000494:pharmacology*; D002471:Cell Transformation, Neoplastic / Q000187:drug effects*; D002478:Cells, Cultured; D003408:Cresols / Q000494:pharmacology*; D006224:Cricetinae; D006900:Hydroxylation; D051381:Rats
D000840:Anisoles; D001580:Benzopyrenes; D003408:Cresols; D002084:Butylated Hydroxytoluene; D002083:Butylated Hydroxyanisole