[Postoperative prevention of thrombosis through the tonicizing of the caudal venous system. A new principle of drug therapy].
Haemostasis of the lower extremities is among the constituent factors of postoperative thrombosis risks ("Virchow's Trias"). Therapeutical efforts have, therefore, ever since focused on the idea of accelerating vein circulation. An equivalent effect is produced by Dihydergot which is thus qualified for postoperative thrombo-prophylaxis. This investigation proves the efficiency ofDihydergot. Results are based on 148 patients subject to longitudinal section tests along the 125-J-fibrinogen-test lines, from the 1st through to the 6th day after operation. In comparison with a control group, the results with the members of the therapy group gave evidence of a highly significant reduction of thrombosis frequency in the leg veins. Side-effects have not been noted. Tonus of the vessels and acceleration of the vein backflow by Dihydergot form a new therapeutical principle within the scope of postoperative thrombo-prophylaxis. The method is advantageous because it is highly efficient, practicable without complications, and is riskfree.
D001775:Blood Circulation; D002395:Catecholamines / Q000494:pharmacology; D004087:Dihydroergotamine / Q000494:pharmacology; D004879:Ergotamines; D005081:Exercise Therapy; D005260:Female; D005340:Fibrinogen; D006487:Hemostasis; D006801:Humans; D007457:Iodine Radioisotopes; D007866:Leg / Q000098:blood supply*; D008297:Male; D008875:Middle Aged; D009129:Muscle Tonus / Q000187:drug effects*; D009638:Norepinephrine / Q000494:pharmacology; D011182:Postoperative Care; D011183:Postoperative Complications / Q000517:prevention & control; D013268:Stimulation, Chemical; D013923:Thromboembolism / Q000188:drug therapy* / Q000517:prevention & control; D013924:Thrombophlebitis / Q000175:diagnosis / Q000209:etiology; D014680:Veins / Q000187:drug effects* / Q000503:physiopathology
D002395:Catecholamines; D004879:Ergotamines; D007457:Iodine Radioisotopes; D004087:Dihydroergotamine; D005340:Fibrinogen; D009638:Norepinephrine
Postoperative Thromboseprophylaxe durch Tonisierung des kaudalen Venensystems. Ein neues medikamentöses Behandlungsprinzip