A model system for investigating the biliary excretion of an anion in the rat.
1. The biliary excretion of phenolphthalein di[35S]sulphate was studied in rats. 2. The conjugate was administered by continuous infusion at rates of 3, 4.5, 6, 9 and 12 mug/min, and kinetic analysis of the rate of biliary excretion was consistent with a two-compartment open-model system. 3. The results obtained after single injections of the ester were also consistent with the model. 4. An essential feature of the model is the presence of a compartment into which the ester may pass as an alternative to direct excretion via the bile. 5. It is suggested that such a compartment may be located within the liver.
D000818:Animals; D000838:Anions / Q000378:metabolism*; D001646:Bile / Q000378:metabolism; D001659:Biliary Tract / Q000378:metabolism*; D007263:Infusions, Parenteral; D007700:Kinetics; D008297:Male; D008954:Models, Biological; D010635:Phenolphthaleins / Q000008:administration & dosage / Q000378:metabolism; D051381:Rats
D000838:Anions; D010635:Phenolphthaleins