Ovarian hyperstimulation syndrome.
Eighteen patients hospitalized for excessive ovarian hyperstimulation syndrome are reported. In 14 cases the ovarian hyperstimulation was induced by human menopausal -onadotropins and in 4 cases by combined treatment with clomiphene and HCG. In 5 patients the hyperstimulation was associated with conception, which resulted in 1 quintuplet delivery, 1 early quintuplet abortion, 1 twin abortion, 1 normal delivery, and  1 missed abortion. The regimen of treatment was a conservative one. The patients were hospitalized and treated with infusion of plasma expanders. Anticoagulant therapy was administered only in cases that showed clinical evidence of thromboembolic pheomena or laboratory evidence of severe hemoconcentration. The pathogenesis of the ovarian hyperstimulation syndrome, prevention, and management are discussed. This syndrome should be diagnosed early and treated intensively.
D000006:Abdomen, Acute / Q000139:chemically induced; D000328:Adult; D000858:Anovulation / Q000188:drug therapy; D001201:Ascites / Q000139:chemically induced; D001826:Body Fluids / Q000378:metabolism; D006063:Chorionic Gonadotropin / Q000009:adverse effects* / Q000627:therapeutic use; D002996:Clomiphene / Q000009:adverse effects* / Q000627:therapeutic use; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D007049:Iatrogenic Disease; D007247:Infertility, Female / Q000188:drug therapy; D008596:Menotropins / Q000009:adverse effects* / Q000627:therapeutic use; D008599:Menstruation Disturbances / Q000188:drug therapy; D010048:Ovarian Cysts / Q000139:chemically induced; D010049:Ovarian Diseases / Q000628:therapy; D010053:Ovary / Q000187:drug effects*; D010952:Plasma Substitutes / Q000627:therapeutic use; D011247:Pregnancy; D011272:Pregnancy, Multiple; D013268:Stimulation, Chemical; D013577:Syndrome
D006063:Chorionic Gonadotropin; D010952:Plasma Substitutes; D002996:Clomiphene; D008596:Menotropins