Effect of diphenylhydantoin and lithium on whole brain serotonin, sodium and potassium in mice.
The effect of lithium and Diphenylhydantoin separately and in combination on whole brain serotonin, sodium and potassium were studied in mice. 9 day treatment with lithium was found to significantly raise brain serotonin. Lithium enhanced the sodium lowering effect of diphenylhydantoin. Though neither drug affected brain potassium, combination of the two drugs significantly lowered brain potassium. The possible mechanisms of these effects are discussed.
D000818:Animals; D001921:Brain / Q000378:metabolism*; D001923:Brain Chemistry; D003864:Depression, Chemical; D004357:Drug Synergism; D008094:Lithium / Q000494:pharmacology*; D051379:Mice; D010672:Phenytoin / Q000494:pharmacology*; D011188:Potassium / Q000378:metabolism*; D012701:Serotonin / Q000378:metabolism*; D012964:Sodium / Q000378:metabolism*; D013268:Stimulation, Chemical
D012701:Serotonin; D010672:Phenytoin; D008094:Lithium; D012964:Sodium; D011188:Potassium