Experimental studies on the pathogenesis and prophylaxis of stroke in stroke-prone spontaneously hypertensive rats (SHR).(1) Quantitative estimation of cerebrovascular permeability.
The cerebrovascular permeability quantitatively determined by the retention of 131I-human albumin in the perfused brains was increased in SHR, especially in stroke-prone SHR compared with normotensive Wistar-Kyoto, and confirmed the macroscopical or microscopical findings on the leakage into the brain or trypan blue or peroxidase injected intravenously 2 to 3 hours before sacrifice. The localization of increased vascular permeability in SHR corresponded to the predilection sites of cerebral hemorrhage or softening, which developed likely following the increased cerebrovascular permeability.
D000818:Animals; D002199:Capillary Permeability; D002560:Cerebrovascular Circulation; D002561:Cerebrovascular Disorders / Q000209:etiology*; D006973:Hypertension / Q000150:complications / Q000503:physiopathology*; D010544:Peroxidases; D051381:Rats; D012711:Serum Albumin, Radio-Iodinated; D014343:Trypan Blue
D012711:Serum Albumin, Radio-Iodinated; D010544:Peroxidases; D014343:Trypan Blue