[Dose-effect study on the bronchospasmolytic drug ipratropium bromide in relation to blood gases and hemodynamics].
In 9 patients with chronic bronchitis and cor puomonale and in one patient with vascularly pulmonary hypertension the efficiency of 0,04 mug and 0,16 mug Sch 1000 (isopropylatropin,), applicated with metered dose inhaler referring to blood gases and hemodynamics was examined. Inhalation of drug was not followed by any variations either referring to hemodynamic parameters (pulmonary pressure, systemic blood pressure, cardiac output, peripheral resistance) nor to the blood gases. After a dosage as high as eigth time as normal side effects were not found.
D001145:Arrhythmias, Cardiac / Q000503:physiopathology; D001286:Atropine Derivatives / Q000494:pharmacology*; D001794:Blood Pressure / Q000187:drug effects; D001965:Bromides; D001991:Bronchitis / Q000503:physiopathology; D001993:Bronchodilator Agents / Q000494:pharmacology*; D002245:Carbon Dioxide / Q000097:blood*; D002302:Cardiac Output / Q000187:drug effects; D002908:Chronic Disease; D004305:Dose-Response Relationship, Drug; D005260:Female; D006439:Hemodynamics / Q000187:drug effects*; D006801:Humans; D006976:Hypertension, Pulmonary / Q000503:physiopathology; D000860:Hypoxia / Q000503:physiopathology; D008297:Male; D010100:Oxygen / Q000097:blood*; D010313:Partial Pressure; D011660:Pulmonary Heart Disease / Q000503:physiopathology; D014655:Vascular Resistance / Q000187:drug effects
D001286:Atropine Derivatives; D001965:Bromides; D001993:Bronchodilator Agents; D002245:Carbon Dioxide; D010100:Oxygen
Dosis- Wirkungs-Studie zum Iinfluss des Bronchospasmolytikums Ipratropiumbronid auf Blutgase und Hämodynamik