Evaluation of the asymmetry of renal sodium excretion in patients with renal artery stenosis.
Despite the fact that excretion and reabsorption fractions of sodium and water should express complementary aspects of the same renal process, calculation of ratios of excretion and reabsorption fractions in both kidneys can lead to differences in results. A theoretical analysis demonstrates that from the physiological point of view it is more correct to evaluate asymmetry on the basis of the ratios of reabsorption fractions. In 13 patients with renal artery stenosis, changes in reabsorption and excretion fractions of sodium, all osmotically active substances and water investigated before and after furosemide administration. The ratios of reabsorption fractions of sodium increased in 9 cases and syymmetry in function on the two sides was accentuated. It is suggested that separate investigation of tubular reabsorption of sodium and water in patients with renal artery stenosis should be combined with administration of furosemide and that the evaluation should be carried out on the basis of calculation of reabsorption fractions.
D000328:Adult; D004231:Diuresis / Q000187:drug effects; D005260:Female; D005665:Furosemide / Q000494:pharmacology; D005919:Glomerular Filtration Rate; D006801:Humans; D007684:Kidney Tubules / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D009318:Natriuresis; D009997:Osmotic Pressure; D012078:Renal Artery Obstruction / Q000175:diagnosis / Q000503:physiopathology / Q000652:urine; D014546:Urinary Catheterization
D005665:Furosemide