Pharmacodynamics of propylthiouracil in normal and hyperthyroid subjects after a single oral dose.
Serum levels of propylthiouracil were measured in 8 normal persons and in 7 patients with hyperthyroidism after a single, 300 mg, oral dose of 6-n-propyl-2-thiouracil (PTU). The patients with hyperthyroidism were restudied after 3, 6, and 9 weeks of individualized treatment with PTU. The serum half-life of the drug in normal subjects was 1.65 h. In patients with hyperthyroidism the serum half-life was similar, and it did not change significantly as the euthyroid state was achieved.
D006207:Half-Life; D006801:Humans; D006980:Hyperthyroidism / Q000097:blood* / Q000188:drug therapy; D011441:Propylthiouracil / Q000097:blood* / Q000627:therapeutic use; D013961:Thyroid Gland / Q000502:physiology* / Q000503:physiopathology; D013974:Thyroxine / Q000097:blood; D013997:Time Factors
D011441:Propylthiouracil; D013974:Thyroxine