Effect of dieldrin toxicity on acetate and palmitate metabolism in rat liver.
The effect of a single oral dose of dieldrin (30 mg/kg body weight) on lipid metabolism in rats was studied. Liver lipids content increased and this increase was mainly in the triglyceride fraction. The incorporation of acetate-14C into fatty acids was decreased indicating an inhibition of lipogenesis. Fatty acid oxidation was increased. Palmitate-14C incorporation into the triglyceride fraction was enhanced pointing to an overall increased utilization of fatty acids.
D000085:Acetates / Q000378:metabolism*; D000284:Administration, Oral; D000818:Animals; D001835:Body Weight / Q000187:drug effects; D003864:Depression, Chemical; D004026:Dieldrin / Q000008:administration & dosage / Q000494:pharmacology*; D005227:Fatty Acids / Q000378:metabolism; D050356:Lipid Metabolism; D008099:Liver / Q000033:anatomy & histology / Q000378:metabolism*; D008297:Male; D009929:Organ Size; D010168:Palmitates / Q000378:metabolism*; D010169:Palmitic Acids / Q000378:metabolism*; D051381:Rats; D013268:Stimulation, Chemical; D014280:Triglycerides / Q000378:metabolism
D000085:Acetates; D005227:Fatty Acids; D010168:Palmitates; D010169:Palmitic Acids; D014280:Triglycerides; D004026:Dieldrin