Sodium restriction and thiazide diuretics in the treatment of hypertension.
In a group of hypertensive patients it has been shown that moderate sodium chloride restriction has a hypotensive effect that is similar to that produced by thiazide diuretics. Blood pressure changed in relation to body weight in individual patients, and appeared to correlate with their sodium balance. The more a patient was depleted of sodium, the lower was the blood pressure. The serum potassium level fell with the use of thiazide diuretics, but in this group of patients there was little change in total body potassium content. The fall in serum potassium level appeared to relate to a shift into the cells due to the accompanying alkalosis. Potassium supplementation appeared to have had little effect and was unnecessary for most patients who were given diuretics for hypertension. Amiloride corrected the alkalosis and restored the serum potassium level to normal.
D000584:Amiloride / Q000494:pharmacology / Q000627:therapeutic use; D001639:Bicarbonates / Q000097:blood; D001835:Body Weight / Q000187:drug effects; D002740:Chlorothiazide / Q000627:therapeutic use; D004039:Diet, Sodium-Restricted; D004232:Diuretics; D006801:Humans; D006852:Hydrochlorothiazide / Q000627:therapeutic use; D006973:Hypertension / Q000097:blood / Q000378:metabolism / Q000628:therapy*; D008297:Male; D008875:Middle Aged; D011188:Potassium / Q000032:analysis / Q000097:blood; D011189:Potassium Chloride / Q000627:therapeutic use; D049993:Sodium Chloride Symporter Inhibitors / Q000494:pharmacology / Q000627:therapeutic use*; D014527:Uric Acid / Q000097:blood
D001639:Bicarbonates; D004232:Diuretics; D049993:Sodium Chloride Symporter Inhibitors; D006852:Hydrochlorothiazide; D014527:Uric Acid; D011189:Potassium Chloride; D002740:Chlorothiazide; D000584:Amiloride; D011188:Potassium