4-Amino-5-arylpyrimidines as antiinflammatory agents.
4-Amino-5-arylpyrimidines were synthesized by a variety of methods and have demonstrated antiinflammatory activity in the carrageenan-induced edema in the rat but displayed little activity against adjuvant-induced arthritis in rats or against uv-induced erythema in guinea pigs.
D000818:Animals; D000893:Anti-Inflammatory Agents / Q000138:chemical synthesis* / Q000627:therapeutic use; D001172:Arthritis, Rheumatoid / Q000188:drug therapy; D002351:Carrageenan; D004487:Edema / Q000188:drug therapy; D004890:Erythema / Q000188:drug therapy; D005620:Freund's Adjuvant; D006168:Guinea Pigs; D011743:Pyrimidines / Q000138:chemical synthesis* / Q000627:therapeutic use; D051381:Rats; D014466:Ultraviolet Rays
D000893:Anti-Inflammatory Agents; D011743:Pyrimidines; D002351:Carrageenan; D005620:Freund's Adjuvant