Tumor localization of 131-I-labeled antibodies by radionuclide inaging.
Intravenous injections of 131-I-labeled anti-EL4 lymphoma antibodies showed progressive localization of radioactivity in EL4 transplants but not in B16 melanoma in mice carrying both tumors. Normal rabbit globulin labeled with 131-I did not localize in either tumor and cleared more slowly from the internal organs. Metastatic localization of intravenous 131-I-labeled anti-tumor antibodies was also observed in 2 cancer patients.
D000818:Animals; D000912:Antibodies, Neoplasm / Q000032:analysis*; D001345:Autoradiography; D001551:Benz(a)Anthracenes; D006041:Goats / Q000276:immunology; D006801:Humans; D007457:Iodine Radioisotopes; D008223:Lymphoma / Q000139:chemically induced / Q000175:diagnosis* / Q000276:immunology; D008545:Melanoma / Q000175:diagnosis* / Q000276:immunology; D051379:Mice; D008810:Mice, Inbred C57BL; D009374:Neoplasms, Experimental / Q000139:chemically induced / Q000175:diagnosis / Q000276:immunology; D011817:Rabbits / Q000276:immunology; D011877:Radionuclide Imaging
D000912:Antibodies, Neoplasm; D001551:Benz(a)Anthracenes; D007457:Iodine Radioisotopes