The effect of the short-acting barbiturate enibomal (Narcodorm) on systolic time intervals.
The systolic time intervals were studied in 16 surgical patients without heart disease between 29 and 75 years of age by a non-invasive technique before and after an induction dose of enibomal (Narcodorm). The pre-injection period/left ventricular ejection time-ratio (PEP/LVET-ratio) increased between 8 and 60% and (1/PEP-2) decreased between 3 and 50%, indicating a reduction of myocardial contractility under the influence of enibomal. Factors responsible for circulatory depression during barbiturate anaesthesia are discussed.
D000328:Adult; D000368:Aged; D000498:Allyl Compounds / Q000008:administration & dosage / Q000494:pharmacology; D001463:Barbiturates / Q000008:administration & dosage / Q000494:pharmacology*; D004562:Electrocardiography; D005260:Female; D006352:Heart Ventricles / Q000187:drug effects*; D006801:Humans; D007275:Injections, Intravenous; D008297:Male; D008875:Middle Aged
D000498:Allyl Compounds; D001463:Barbiturates; C010308:pronarcon