Investigation of some materials as dry binders for direct compression in tablet manufacture. Part 3: Effect of diluents.
The effects of lactose and dibasic calcium phosphate as diluents on the dry-binding qualities of tragacanth, polyethylene glycol 4000, polyvinylpyrrolidone and mannitol were investigated. The type, concentration and particle size of the diluent appeared to influence the flowability and the binding properties of the binders investigated.
D000042:Absorption; D002130:Calcium Phosphates; D002626:Chemistry, Pharmaceutical; D004339:Drug Compounding; D006244:Hardness; D007785:Lactose; D008353:Mannitol; D010316:Particle Size; D010592:Pharmaceutic Aids; D011092:Polyethylene Glycols; D011134:Polysaccharides; D011205:Povidone; D011312:Pressure; D013607:Tablets; D014867:Water
D002130:Calcium Phosphates; D010592:Pharmaceutic Aids; D011134:Polysaccharides; D013607:Tablets; D014867:Water; D008353:Mannitol; D011092:Polyethylene Glycols; D011205:Povidone; D007785:Lactose