A "cytotoxic" factor released from unactivated human lymphocytes.
A protein mixture named LTx, was released from human tonsillar lymphocytes, when incubated at 37 degrees C in either "individual" or "mixed" cultures. LTx caused a decrease in the incorporation of 14C-labelled amino acids of the target lymphocytes, while the release of 51Cr from labelled target cells increased. Target cells were found to bind the "toxic" protein.
D000596:Amino Acids / Q000378:metabolism; D002478:Cells, Cultured; D006801:Humans; D007700:Kinetics; D008214:Lymphocytes / Q000502:physiology*; D014066:Palatine Tonsil / Q000502:physiology*; D011506:Proteins / Q000502:physiology*; D013997:Time Factors; D014118:Toxins, Biological / Q000494:pharmacology*; D014633:Valine / Q000378:metabolism
D000596:Amino Acids; D011506:Proteins; D014118:Toxins, Biological; D014633:Valine