The effect of brinase on fibrinogen in vivo.
Brinase infusions in man cause, without excessive lowering of the inhibitor capacity, a slowing of the fibrin polymerization. This is combined with a degradation of the A alpha chain into two major fragments. Both fragments carry crosslinking sites. Brinase infusion also causes positive ethanol gelation. Evidence for the formation of gamma dimers was found.
D001230:Aspergillus / Q000201:enzymology; D001780:Blood Coagulation Tests; D004591:Electrophoresis, Polyacrylamide Gel; D000431:Ethanol; D005340:Fibrinogen / Q000378:metabolism*; D006801:Humans; D006868:Hydrolysis; D008968:Molecular Conformation; D008970:Molecular Weight; D010447:Peptide Hydrolases / Q000008:administration & dosage / Q000494:pharmacology*; D011480:Protease Inhibitors
D011480:Protease Inhibitors; D000431:Ethanol; D005340:Fibrinogen; D010447:Peptide Hydrolases