Dopamine-beta-hydroxylase after treatment with beta-blockers in hypertension.
Dopamine-beta-hydroxylase (DBH) the enzyme responsible for the biosynthesis of noradrenaline from dopamine, was assayed in the blood plasma of 19 cases with hypertension before and during beta-receptor blockade. Propranolol was given to 15 patients and I.C.I. 66,082 (a new cardioselective beta-adrenergic blocker without intrinsic sympathomimetic properties) to 4 patients. - There was no effect by the drugs on the level of plasma DBH activity in spite of a good reduction of the blood pressure.
D001262:Atenolol / Q000494:pharmacology* / Q000627:therapeutic use; D001794:Blood Pressure / Q000187:drug effects; D004299:Dopamine beta-Hydroxylase / Q000097:blood*; D006801:Humans; D006973:Hypertension / Q000188:drug therapy / Q000201:enzymology*; D008297:Male; D011412:Propanolamines / Q000494:pharmacology*; D011433:Propranolol / Q000494:pharmacology* / Q000627:therapeutic use
D011412:Propanolamines; D001262:Atenolol; D011433:Propranolol; D004299:Dopamine beta-Hydroxylase