[Research on substances with antiblastic activity. LVIII. Synthesis and antineoplastic activity of derivatives of pyrrolo-(1,2-a)quinoxaline].
Some derivatives of pyrrolo[1,2-a]quinoxaline and 7,8-dimethoxypyrrolo[1,2-a]quinoxaline, structurally related to two antitumoral antibiotics, mitomycin C and anthramycin, have been prepared. The synthesis of the two nuclei was carried out starting from the required nitroaniline and 2,5-diethoxytetrahydrofuran; formylation of the pyrrole derivative and successive reduction gave the heterocyclic compound directly. Antineoplastic activity was evaluated on mice treated intraperitoneally with leukemia L 1210.
D000818:Animals; D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000627:therapeutic use; D002626:Chemistry, Pharmaceutical; D004353:Drug Evaluation, Preclinical; D007939:Leukemia L1210 / Q000188:drug therapy; D051379:Mice; D011758:Pyrroles / Q000138:chemical synthesis* / Q000627:therapeutic use; D011810:Quinoxalines / Q000138:chemical synthesis* / Q000627:therapeutic use
D000970:Antineoplastic Agents; D011758:Pyrroles; D011810:Quinoxalines
Ricerche su sostanze ad attivitá antiblastica LVIII - Sintesi ed attivitá antineoplastica di derivati della pirrolo[1,2-a]chinossaline