Comparison of observed and predicted bioavailability of nortriptyline in humans following oral administration.
The first-pass equation based on the dose, hepatic blood flow, and total area under the plasma level-time curve after oral administration was used retrospectively to predict the bioavailability of nortriptyline after oral administration of 1 mg/kg-single oral doses to monozygotic and dizygotic twin pairs. The predicted values of bioavailability ranged from 45 to 85%, consistent with experimentally derived estimates of nortriptyline availability.
D000284:Administration, Oral; D001682:Biological Availability; D001702:Biopharmaceutics; D001783:Blood Flow Velocity; D004305:Dose-Response Relationship, Drug; D006801:Humans; D008099:Liver / Q000098:blood supply / Q000378:metabolism; D009661:Nortriptyline / Q000008:administration & dosage / Q000097:blood* / Q000378:metabolism
D009661:Nortriptyline