[Metabolism and toxicity of therapeutic chelating agents. 14. Effect of DTPA on hematopoiesis].
By use of 3-H-thymidine it is shown that toxic doses of Ca-DTPA lead to a reversible inhibition of DNA-synthesis in the lymphocytes, erythro- and myelopoietic cells of the rat. The incorporation of 59-Fe into the erythrocytes is markedly imparied. The hematological reaction, i. e. granulocytosis, lympho- and eosinopenia, is ascribed to the general adaptation syndrom. Zn-DTPA proved to be ineffective in all respects.
D000818:Animals; D002118:Calcium; D004247:DNA / Q000096:biosynthesis; D004305:Dose-Response Relationship, Drug; D004804:Eosinophils / Q000187:drug effects; D004912:Erythrocytes / Q000187:drug effects; D005260:Female; D006410:Hematopoiesis / Q000187:drug effects*; D006454:Hemoglobins; D007504:Iron Radioisotopes / Q000378:metabolism; D008214:Lymphocytes / Q000187:drug effects; D008938:Mitosis / Q000187:drug effects; D009000:Monocytes / Q000187:drug effects; D009504:Neutrophils / Q000187:drug effects; D004369:Pentetic Acid / Q000378:metabolism / Q000633:toxicity*; D051381:Rats; D013936:Thymidine; D014316:Tritium; D015032:Zinc
D006454:Hemoglobins; D007504:Iron Radioisotopes; D014316:Tritium; D004369:Pentetic Acid; D004247:DNA; D015032:Zinc; D002118:Calcium; D013936:Thymidine
Metabolismus und Toxizität therapeutischer Chelatbildner. XIV. Mitteilung: Wirkung von DTPA auf die Hämatopoese