The effects of chemical structure and surface properties of synthetic polymers on the coagulation of blood. IV. The relation between polymer morphology and protein adsorption.
Although these studies are preliminary, they do not show that the chemical structure of the block copolymer is not the only determinant of its blood properties; one must be equally concerned with the effect of its domain-matrix size and purity. These features, which are affected by factors such as block size, mold surface, and general fabrication procedures, as well as chemical structure, must be controlled if one is to have reproducible results in the function of an implant.
D000327:Adsorption; D000818:Animals; D001777:Blood Coagulation / Q000187:drug effects*; D001798:Blood Proteins / Q000378:metabolism*; D055598:Chemical Phenomena; D002621:Chemistry; D006224:Cricetinae; D005337:Fibrin / Q000378:metabolism; D005340:Fibrinogen / Q000378:metabolism; D005347:Fibroblasts / Q000187:drug effects; D007668:Kidney / Q000166:cytology; D008968:Molecular Conformation; D010973:Platelet Adhesiveness / Q000187:drug effects; D010974:Platelet Aggregation / Q000187:drug effects; D011108:Polymers / Q000378:metabolism / Q000494:pharmacology*; D011126:Polypropylenes / Q000494:pharmacology; D011138:Polytetrafluoroethylene / Q000378:metabolism / Q000494:pharmacology*; D011140:Polyurethanes / Q000378:metabolism / Q000494:pharmacology*; D012709:Serum Albumin / Q000378:metabolism; D012712:Serum Globulins / Q000378:metabolism; D012826:Silicone Elastomers / Q000378:metabolism / Q000494:pharmacology*; D013329:Structure-Activity Relationship; D013499:Surface Properties
D001798:Blood Proteins; D011108:Polymers; D011126:Polypropylenes; D011140:Polyurethanes; D012709:Serum Albumin; D012712:Serum Globulins; D012826:Silicone Elastomers; D005337:Fibrin; D005340:Fibrinogen; D011138:Polytetrafluoroethylene