Glycerol effects on the perilymphatic and cerebro-spinal fluid pressure.
Glycerol has been injected intravenously in guinea pig and its effects on the pressure in the cochlear fluids have been studied. Simultaneously, arterial and cerebro-spinal pressures have been recorded. Glycerol lowered the intracochlear as well as cerebro-spinal and blood pressures, the latter only temporarily. Different possible mechanisms for the glycerol effect on the intracochlear pressure and its transient effect on hearing in Menière's disease are discussed.
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D003051:Cochlea / Q000187:drug effects; D003864:Depression, Chemical; D005990:Glycerol / Q000008:administration & dosage / Q000494:pharmacology*; D006168:Guinea Pigs; D007275:Injections, Intravenous; D007427:Intracranial Pressure / Q000187:drug effects*; D007761:Labyrinthine Fluids / Q000187:drug effects*; D010498:Perilymph / Q000187:drug effects*; D011312:Pressure; D013268:Stimulation, Chemical; D013997:Time Factors; D014280:Triglycerides / Q000097:blood
D014280:Triglycerides; D005990:Glycerol