Blockade of reserpine emesis in pigeons by metoclopramide.
Reserpine (0.5 mg/kg i.m.) produced emesis in pigeons with 60% of the animals responding. Metoclopramide HCl at 10, 20 and 40 mg/kg p.o. administered 30 min before or after reserpine injection was effective in blocking reserpine emesis. Metoclopramide was unable to antagonize reserpine-induced sedation and hypotension in rats, thus inviting discussion of its possible mechanism in blocking reserpine emesis.
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D010856:Columbidae / Q000502:physiology*; D005260:Female; D006993:Hypnotics and Sedatives / Q000037:antagonists & inhibitors; D008297:Male; D008787:Metoclopramide / Q000494:pharmacology*; D012110:Reserpine / Q000037:antagonists & inhibitors* / Q000494:pharmacology; D014839:Vomiting / Q000139:chemically induced*
D006993:Hypnotics and Sedatives; D012110:Reserpine; D008787:Metoclopramide