Experimental brain damage from fluid pressures due to impact acceleration. 2. Pathophysiological observations.
The significance of the intracranial acceleration pressure pattern at impact to the intact skull in production of brain damage is discussed, particularly as regards the contre-coup pressures. A rigid fluid-filled cylinder was connected to the skull cavity of rabbits; the cylinder was impacted and the intracranial contents acted as a contre-coup end. The pressure pattern was also modified by injection of small quantified air volumes. The pathophysiological effects of "experimental brain concussion" with vasomotor and respiratory disturbances which occurred were related to the contre-coup pressures produced, particularly the magnitude of subatmospheric pressures and the duration of late positive pressures. Some implications on their significance for brain tissue flow are discussed.
D000054:Acceleration; D000818:Animals; D001274:Atmospheric Pressure; D001930:Brain Injuries / Q000503:physiopathology*; D004195:Disease Models, Animal; D005260:Female; D007427:Intracranial Pressure; D008297:Male; D008722:Methods; D011817:Rabbits; D012119:Respiration; D013997:Time Factors; D014666:Vasomotor System / Q000503:physiopathology*