Therapy and prognosis of hypertension in chronic nephritis.
Statistical analysis of the realtion between blood pressure and renal function in 421 patients with CGN, referred to the Second Internal Medicine at Nihon University Hospital, and in 253 Hypertensive patients with CGN by questionaires sent to 29 Medical Universities were investigated. The relationship between survival rate and blood pressure of 84 patients with CGN in Surugadai Nihon University Hospital was also examined. These data show that antihypertensive therapy for CGN with hypertension has an important effect on prognosis. Propranolol was given to 10 hypertensive patients with CGN and hypotensive effect on renal function was observed. Our experience suggests that propranolol may be useful for treating a high renin component in the hypertension with non renal failure, and renal function does not become worse. But in renal failure, propranolol therapy must be used carefully because of inducement to cardiac failure.
D000328:Adult; D000450:Aldosterone / Q000097:blood; D000804:Angiotensin II / Q000097:blood; D001810:Blood Volume; D002395:Catecholamines / Q000378:metabolism; D002908:Chronic Disease; D003404:Creatinine / Q000097:blood; D005110:Extracellular Space; D005260:Female; D005921:Glomerulonephritis / Q000150:complications*; D006801:Humans; D006830:Hydralazine / Q000627:therapeutic use; D006973:Hypertension / Q000209:etiology; D006977:Hypertension, Renal / Q000188:drug therapy / Q000209:etiology* / Q000401:mortality; D008297:Male; D008750:Methyldopa / Q000627:therapeutic use; D008875:Middle Aged; D011379:Prognosis; D011433:Propranolol / Q000627:therapeutic use
D002395:Catecholamines; D000804:Angiotensin II; D006830:Hydralazine; D000450:Aldosterone; D008750:Methyldopa; D011433:Propranolol; D003404:Creatinine