Probable neonatal propoxyphene withdrawal: a case report.
A baby with neonatal withdrawal from propoxyphene as evidenced by severe diarrhea, flapping tremors, shrill cry, diaphoresis, hypertonicity, and seizures is presented. Propoxyphene and its metabolites were identified in the patient's serum and urine. We express concern about the wide use of propoxyphene and its proposed use in substitution programs for detoxifying and maintaining heroin addicts in view of the possibility of neonatal complications.
D011431:Dextropropoxyphene / Q000009:adverse effects* / Q000097:blood / Q000652:urine; D003967:Diarrhea / Q000139:chemically induced; D005260:Female; D005333:Fetus / Q000187:drug effects*; D006801:Humans; D006948:Hyperkinesis / Q000139:chemically induced; D007231:Infant, Newborn; D007232:Infant, Newborn, Diseases / Q000139:chemically induced*; D008297:Male; D008431:Maternal-Fetal Exchange; D011247:Pregnancy; D012640:Seizures / Q000139:chemically induced; D013375:Substance Withdrawal Syndrome; D019966:Substance-Related Disorders; D014202:Tremor / Q000139:chemically induced
D011431:Dextropropoxyphene