Experience with clinical and operative staging of Hodgkin's disease in children.
Accurate staging is critical for the proper treatment of Hodgkin's disease. In the past 5 yr, 60 children with Hodgkin's disease were staged by celiotomy which included splenectomy and biopsy of liver, retroperitoneal lymph nodes, and bone. Fifty children underwent staging celiotomy at initial diagnosis (Group I). Ten others were staged surgically because of suspected reactivation of disease diagnosed and treated before current staging methods were employed (Group II). Forty-one of 50 children in Group I had Stage I or II disease, seven Stage III, and two Stage IV. As a result of operation, therapy was altered in seven children. Three had a higher stag e and four a lower stage than that suspected by clinical evaluation, including two with liver involvement. Of the two patients in Group II, celiotomy revealed unsuspected splenic disease in seven, including one with liver involvement. Celiotomy and splenectomy were well tolerated and no long-term complications have been noted (average follow-up 2 yr). Forty-nine of 50 children in Group I and six of ten in Group II are alive without disease. No cases of sepsis attributable to splenectomy have been observed.
D000293:Adolescent; D001365:Axilla; D001706:Biopsy; D002648:Child; D002675:Child, Preschool; D005260:Female; D006689:Hodgkin Disease / Q000473:pathology* / Q000601:surgery / Q000628:therapy; D006801:Humans; D007264:Inguinal Canal; D008099:Liver / Q000473:pathology; D008111:Liver Function Tests; D008198:Lymph Nodes / Q000473:pathology; D008220:Lymphography; D008297:Male; D008482:Mediastinum; D009333:Neck; D013902:Radiography, Thoracic; D012186:Retroperitoneal Neoplasms / Q000473:pathology; D013156:Splenectomy; D014054:Tomography