Carcinogenic and cocarcinogenic effects of inhaled synthetic smog and ferric oxide particles.
The carcinogenic and cocarcinogenic activity of synthetic smog, ferric oxide (Fe2O3) dust, and a mixture of the two air contaminants was determined in a long-term inhalation study with Syrian hamsters. Inhaled Fe2O3 particles definitely enhanced diethylnitrosamine tumorigenicity in the peripheral lung. Synthetic smog did not. When tested at a concentration of 40 ppm methane equivalents or 40 mg/m3, respectively, neither air pollutant by itself appeared carcinogenic. Fe2O3 caused pulmonary fibrosis and synthetic smog caused alveolar bronchiolization in many of the exposed animals.
D000393:Air Pollutants; D000818:Animals; D001835:Body Weight / Q000187:drug effects; D002273:Carcinogens; D006224:Cricetinae; D004052:Diethylnitrosamine / Q000633:toxicity; D004357:Drug Synergism; D005290:Ferric Compounds / Q000032:analysis / Q000633:toxicity*; D007501:Iron / Q000633:toxicity*; D007822:Laryngeal Neoplasms / Q000139:chemically induced; D008168:Lung / Q000032:analysis; D008171:Lung Diseases / Q000139:chemically induced; D008175:Lung Neoplasms / Q000139:chemically induced; D008297:Male; D009669:Nose Neoplasms / Q000139:chemically induced; D011658:Pulmonary Fibrosis / Q000139:chemically induced; D012142:Respiratory Tract Neoplasms / Q000139:chemically induced*; D012905:Smog; D013997:Time Factors; D014134:Tracheal Neoplasms / Q000139:chemically induced
D000393:Air Pollutants; D002273:Carcinogens; D005290:Ferric Compounds; D012905:Smog; D004052:Diethylnitrosamine; D007501:Iron