Partition coefficients and the structure-activity relationship of the anesthetic gases.
Partition coefficients of 32 gaseous anesthetics in the octanol-water system have been determined. It is shown that relative anesthetic potency depends on hydrophobicity of the anesthetic (as defined by log P) and on a polar factor. The presence of a polar hydrogen in the anesthetic greatly increases potency. A quantitative structure-activity relationship is formulated based on these two factors.
D000777:Anesthetics / Q000494:pharmacology; D000818:Animals; D007700:Kinetics; D051379:Mice; D000442:Octanols; D012018:Reflex / Q000187:drug effects; D012995:Solubility; D013329:Structure-Activity Relationship; D014867:Water
D000777:Anesthetics; D000442:Octanols; D014867:Water