The synthesis and biological activity of alkyloxy prostaglandin analogues.
Prostaglandin analogues in which the alkyl chain attached to C-15 in the natural compounds is replaced by an alkyoxyalkyl group have been synthesised. Compounds of the 17-oxa series are particularly potent luteolytic agents and are selective in the sense that they are less effective than PGE-2alpha in causing isotonic contractions of isolated uterus muscle.
D000478:Alkylation; D008958:Models, Molecular; D010084:Oxidation-Reduction; D011453:Prostaglandins / Q000138:chemical synthesis* / Q000378:metabolism
D011453:Prostaglandins