Relative efficacy of alcohol and propranolol in action tremor.
Thirty-nine patients with a variety of diseases, including essential tremor, Parkinson's Disease, olivopontocerebellar degeneration, ataxia telangiectasia, and cervical cord injury with action tremor, were evaluated for the effect of one ounce of absolute alcohol ingestion. Tremor significantly subsided in 61.9% of E.T.; 46.6% of P.D.; one patient with A.T.; and one patient with C6 lesion. The tremor became worse in one patient with O.P.C.D. Twenty of these patients were treated with propranolol, an average dose of 92 mgm. per day, and re-evaluated three to six months later. All those who improved on alcohol improved on propranolol and the one whose tremor accentuated with alcohol had a similar response to propranolol. It is concluded that the tremorilytic effect of alcohol is neither specific for, nor limited to, essential tremor and is of no value in differentiating various neurological disorders which manifest as action tremor. It is recommended that one ounce of absolute alcohol by mouth be used as an office procedure to predict the response of patients' tremor to propranolol.
D000328:Adult; D001260:Ataxia Telangiectasia / Q000188:drug therapy; D002526:Cerebellar Diseases / Q000188:drug therapy; D004341:Drug Evaluation; D000431:Ethanol / Q000097:blood / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D008297:Male; D010300:Parkinson Disease / Q000188:drug therapy; D011433:Propranolol / Q000627:therapeutic use*; D013119:Spinal Cord Injuries / Q000188:drug therapy; D014202:Tremor / Q000188:drug therapy*
D000431:Ethanol; D011433:Propranolol