Studies in potential filaricides. 6. Synthesis of 3,8-disubstituted 1,3,8-triazabicyclo(4.4.0)decan-2-ones and -thiones.
1,3,8-Triazabicyclo[4.4.0]decan-2-ones and -thiones varying substituents at positions 3 and 8 have been synthesized. When tested in cotton rats for their antifilarial activity against Litomosoides carinii, some of the compounds showed moderate microfilaricidal activity.
D000818:Animals; D000871:Anthelmintics / Q000138:chemical synthesis*; D001372:Aza Compounds / Q000138:chemical synthesis / Q000627:therapeutic use; D001643:Bridged Bicyclo Compounds / Q000138:chemical synthesis* / Q000627:therapeutic use; D001952:Bridged-Ring Compounds / Q000138:chemical synthesis*; D005368:Filariasis / Q000188:drug therapy; D005369:Filaricides / Q000138:chemical synthesis*; D051381:Rats; D013329:Structure-Activity Relationship; D013871:Thiones / Q000138:chemical synthesis / Q000627:therapeutic use
D000871:Anthelmintics; D001372:Aza Compounds; D001643:Bridged Bicyclo Compounds; D001952:Bridged-Ring Compounds; D005369:Filaricides; D013871:Thiones