Abnormal regeneration of hydra induced with vinblastine sulfate.
The effect of vinblastine sulfate on the regeneration of hydra was examined. When the three segments of hydra (fore, mid, and hind segments) were treated with 0.01% vinblastine sulfate immediately after separation, transferred to normal culture medium, and observed for 7 days, various types of abnormal regeneration were observed, especially in the regenerates from the mid segments. Other segments of hydra did not reveal any abnormal pattern of regeneration, although incomplete regeneration or no regeneration of the segments was seen in the advanced period of the treatment. In the case of treatment of the three segments with 0.01% vincristine sulfate, no abnormal regeneration was seen, in spite of marked inhibition of regeneration which was observed in the advanced period of the treatment.
D003470:Culture Media; D006829:Hydra / Q000187:drug effects / Q000502:physiology*; D012038:Regeneration / Q000187:drug effects*; D013431:Sulfates; D014747:Vinblastine / Q000494:pharmacology*
D003470:Culture Media; D013431:Sulfates; D014747:Vinblastine