Striatal dopaminergic modulation of lateral hypothalamic self-stimulation.
The bilateral application of crystalline 6-hydroxydopamine to the ventral anterior head of the corpus striatum of rats severely suppressed responding for electrical stimulation of the lateral hypothalamus. This suppression lasted for days or weeks, after other behavioral deficits in food and  water intake and activity had recovered. Application of crystalline dopamine through the same cannulas temporarily reversed the impairment. Applications of crystalline dopamine to the same striatal region of untreated rats were more effective in enhancing self-stimulation than similar applications of norepinephrine.
D000818:Animals; D003342:Corpus Striatum / Q000502:physiology*; D004298:Dopamine / Q000502:physiology*; D004327:Drinking Behavior / Q000187:drug effects; D005247:Feeding Behavior / Q000187:drug effects; D006892:Hydroxydopamines / Q000494:pharmacology; D007031:Hypothalamus / Q000033:anatomy & histology / Q000502:physiology*; D008297:Male; D009043:Motor Activity / Q000187:drug effects; D009638:Norepinephrine / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D012653:Self Stimulation
D006892:Hydroxydopamines; D004298:Dopamine; D009638:Norepinephrine