[Study of the possibilities of inactivating adeno-associated virus type 4].
Adeno-associated type 4 virus (AAV-4) is inactivated by formalin dilutions 1 : 400, 1 : 1000 and 1 : 2000 for 24 hours at 37 degrees C. Under these conditions hemogglutinins (HA) and complement-fixing antigen (CFA) are retained. The residual formalin must be neutralized with sodium bisulphite. AAV-4 can also be inactivated by 3% hydrogen peroxide and HA and CFA are retained too. Hydrogen peroxide may be neutralized with catalase. No inactivation of AAV-4 could be achieved with lowere concentrations of hydrogen peroxide, even in the presence of copper sulphate.
D003300:Copper / Q000494:pharmacology; D004202:Disinfectants / Q000494:pharmacology; D004203:Disinfection; D005557:Formaldehyde / Q000494:pharmacology; D006358:Hot Temperature; D006861:Hydrogen Peroxide / Q000494:pharmacology; D012526:Satellite Viruses / Q000187:drug effects; D013242:Sterilization; D013431:Sulfates / Q000494:pharmacology
D004202:Disinfectants; D013431:Sulfates; D005557:Formaldehyde; D003300:Copper; D006861:Hydrogen Peroxide
Izuchenie vozmozhnosteĭ inaktivatsii adenoassotsiirovannogo virusa tipa 4