Serologic evidence of hepatitis B virus infection in patients with hemophilia B. a multicenter study.
Among sera from 160 patients with hemophilia B from 9 centers in Europe and North and South America, 2.5% were positive for hepatitis B surface antigen (HBsAg), 60for antibody to HBsAg, and 31% for antibody to the hepatitis B core antigen. Evidence of exposure to the hepatitis B virus appeared to be related to severity of disease and age rather than the source and method of manufacturer of factor IX concentrate.
D000914:Antibodies, Viral / Q000032:analysis; D001782:Blood Donors; D004340:Drug Contamination; D005164:Factor IX / Q000009:adverse effects*; D002836:Hemophilia B / Q000382:microbiology / Q000628:therapy*; D006509:Hepatitis B / Q000209:etiology*; D006511:Hepatitis B Antigens / Q000032:analysis / Q000302:isolation & purification; D006801:Humans; D011863:Radioimmunoassay; D065227:Transfusion Reaction
D000914:Antibodies, Viral; D006511:Hepatitis B Antigens; D005164:Factor IX