Identification of a metabolite of thioridazine and mesoridazine from human plasma.
The major unknown component present in the plasma of all subjects given thioridazine (la) or mesoridazine (lb) has been identified by TLC, GC, and mass spectrometry as thioridazine side-chain sulfone (sulforidazine) (1c).
D055598:Chemical Phenomena; D002621:Chemistry; D002849:Chromatography, Gas; D002855:Chromatography, Thin Layer; D006801:Humans; D007536:Isomerism; D013058:Mass Spectrometry; D008653:Mesoridazine / Q000097:blood* / Q000378:metabolism; D013450:Sulfones / Q000097:blood / Q000378:metabolism; D013881:Thioridazine / Q000097:blood* / Q000378:metabolism
D013450:Sulfones; D008653:Mesoridazine; D013881:Thioridazine