The renal pathology in a case of lithium-induced diabetes insipidus.
A case of lithium-induced diabetes insipidus is reported. At necropsy microscopy shoed unique and extensive damage to cells lining the distal nephron. It is suggested that these changes represent a specific toxic effect of lithium, reported here for the first  time in man.
D000328:Adult; D001714:Bipolar Disorder / Q000188:drug therapy; D003919:Diabetes Insipidus / Q000139:chemically induced* / Q000473:pathology; D003928:Diabetic Nephropathies / Q000473:pathology*; D006801:Humans; D007668:Kidney / Q000187:drug effects*; D007679:Kidney Medulla / Q000473:pathology; D008094:Lithium / Q000009:adverse effects* / Q000097:blood / Q000627:therapeutic use; D008297:Male; D009765:Obesity / Q000150:complications; D011141:Polyuria / Q000139:chemically induced; D013894:Thirst
D008094:Lithium