Clinical evaluation of local anaesthetic agents.
The precise evaluation of local anaesthetic drugs in clinical practice has many difficulties. The factors which may modify the clinical profile of these drugs are: (1) procedural in nature; (2) patient related; (3) drug related; and (4) investigator related. All these factors are discussed in relation to the proper design of clinical trials.
D000367:Age Factors; D000698:Analgesia; D000765:Anesthesia, Conduction / Q000379:methods; D000767:Anesthesia, Epidural; D000779:Anesthetics, Local; D001835:Body Weight; D002045:Bupivacaine; D004305:Dose-Response Relationship, Drug; D004341:Drug Evaluation; D004837:Epinephrine; D006470:Hemorrhage; D006801:Humans; D008012:Lidocaine; D011318:Prilocaine; D012107:Research Design; D013514:Surgical Procedures, Operative; D013997:Time Factors
D000779:Anesthetics, Local; D011318:Prilocaine; D008012:Lidocaine; D002045:Bupivacaine; D004837:Epinephrine