Preparation and anticoagulant activity of trimethylsilyl heparin in Carbowax.
Trimethylsilyl heparin, when administered intraduodenally or intragastrically to rats, did not increase intestinal absorption and, consequently, the clotting times were not influenced. However, suspension of sodium heparin in Carbowax 200 prolonged the whole blood clotting time at a dose of 50 mg/kg when given intraduodenally or intragastrically to rats.
D000818:Animals; D001777:Blood Coagulation / Q000187:drug effects; D001780:Blood Coagulation Tests; D004586:Electrophoresis; D006493:Heparin / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000378:metabolism / Q000494:pharmacology; D006801:Humans; D007408:Intestinal Absorption; D008899:Mineral Oil; D009821:Oils; D014677:Pharmaceutical Vehicles; D011092:Polyethylene Glycols; D011136:Polysorbates; D011817:Rabbits; D051381:Rats; D012825:Silicon; D012995:Solubility; D013329:Structure-Activity Relationship; D014885:Waxes; D003313:Zea mays
D009821:Oils; D014677:Pharmaceutical Vehicles; D011136:Polysorbates; D014885:Waxes; D011092:Polyethylene Glycols; D008899:Mineral Oil; D006493:Heparin; D012825:Silicon