Effects of synthetic somatostatin on endotoxin-induced changes of growth hormone, cortisol and insulin in plasma, blood sugar and blood leukocytes in man.
In normal man synthetic somatostatin inhibits the growth hormone response to intravenous administration of endotoxin (Piromen), but exerts no influence on cortisol plasma levels. Endotoxin-induced leukocytosis in blood is significantly reduced by somatostatin. Plasma levels of insulin and the blood sugar in man receiving endotoxin are firstly reduced in a significant manner and then increasing to normal values during somatostatin infusion.
D000328:Adult; D001786:Blood Glucose / Q000378:metabolism*; D004336:Drug Antagonism; D004731:Endotoxins / Q000494:pharmacology*; D013006:Growth Hormone / Q000097:blood*; D006801:Humans; D006854:Hydrocortisone / Q000097:blood*; D007275:Injections, Intravenous; D007328:Insulin / Q000097:blood*; D007958:Leukocyte Count; D007962:Leukocytes / Q000187:drug effects*; D008297:Male; D011549:Pseudomonas; D011749:Pyrogens / Q000008:administration & dosage / Q000494:pharmacology; D013004:Somatostatin / Q000494:pharmacology*; D013997:Time Factors
D001786:Blood Glucose; D004731:Endotoxins; D007328:Insulin; D011749:Pyrogens; D013004:Somatostatin; D013006:Growth Hormone; D006854:Hydrocortisone