Features of Turner's syndrome in women with polycystic ovaries.
Four women with phenotypic features of Turner's syndrome and with poly  cystic ovaries (PCO) are describe. In addition to  the phenotypic features, Case 1 had primary amenorrhea and small PCO, Case 2  had a 46, XX/45, X karyotype (lumphocytes), Case 3 had enlarged PCO  which contained a  decreased number of oocytes, and Case 4 had enlarged PCO and was short in statute. These cases support the concept of a relation between PCO and the X chromosome. Some PCO may represent an intermediate condition in a spectrum that extends from the streak gonad of Turners syndrome to the normal ovary. Evidience for X chromosome involvement in PCO is summarized. The concept is advanced that at least some cases of OCO may be due to X chromosomal factors causing an abnormal follicular appartus.
D000293:Adolescent; D000568:Amenorrhea / Q000209:etiology; D000735:Androstenedione / Q000097:blood; D002904:Chromosomes, Human, 21-22 and Y; D003593:Cytoplasm / Q000648:ultrastructure; D005260:Female; D005640:Follicle Stimulating Hormone / Q000097:blood; D006628:Hirsutism / Q000209:etiology; D006801:Humans; D007621:Karyotyping; D007986:Luteinizing Hormone / Q000097:blood; D009765:Obesity / Q000209:etiology; D009865:Oocytes / Q000648:ultrastructure; D010641:Phenotype; D011085:Polycystic Ovary Syndrome / Q000097:blood / Q000150:complications / Q000235:genetics*; D013739:Testosterone / Q000097:blood; D014424:Turner Syndrome / Q000150:complications* / Q000235:genetics; D014617:Vacuoles / Q000648:ultrastructure
D013739:Testosterone; D000735:Androstenedione; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone