Q fever (Coxiella burnetii) investigations in dairy cattle: persistence of antibodies after vaccination.
The immune response and persistence of antibodies were investigated in dairy cattle vaccinated with formalin-inactivated phase (ph) I Coxiella burnetii vaccine agglutinating antibody geometric mean titer (GMT) of 193.2 at 1 month after vaccination compared to a GMT of 2.0 for nonvaccinated calves. The agglutinating antibodies gradually decreased in vaccinated cattle, but the GMT remained approximately 4 times higher than that for the nonvaccinated group for at least 20 months. Results of serotests at 2 months after revaccination indicated a rapid increase in the GMT to 177.0 with agglutinating titers between 1:64 and 1:512.
D000372:Agglutination Tests; D000818:Animals; D000907:Antibodies, Bacterial; D000917:Antibody Formation; D000942:Antigens, Bacterial; D002417:Cattle; D002418:Cattle Diseases / Q000276:immunology*; D003168:Complement Fixation Tests; D003381:Coxiella / Q000276:immunology*; D005260:Female; D006168:Guinea Pigs; D007075:Immunoglobulin M / Q000032:analysis; D007279:Injections, Subcutaneous; D008297:Male; D051379:Mice; D011778:Q Fever / Q000276:immunology / Q000662:veterinary*; D012290:Rickettsial Vaccines / Q000008:administration & dosage; D014611:Vaccination / Q000662:veterinary*
D000907:Antibodies, Bacterial; D000942:Antigens, Bacterial; D007075:Immunoglobulin M; D012290:Rickettsial Vaccines