Effects of prolonged administration of triton WR-1339 to the rat on morphology and phospholipids of liver.
Rats received 10 injections of Triton WR-1339 over a 4-week period. Light and electron microscopy and analysis of lipids and acid phosphatase were performed on livers of untreated controls, of animals taken during the period of treatment, and of animals allowed 2 weeks to recover. The only morphologic change resulting from the treatment was the appearance in both hepatocytes and Kupffer cells of after cessation of treatment, the change in hepatocytes had almost disappeared whereas it had become accentuated in the Kupffer cells. The treatments resulted in a 75 per cent increase in the concentration of lipids which includes Triton taken into the liver, a 17 per cent decrease in concentration of total phospholipid and a 26 per cent increase in acid phosphatase. Among phospholipid classes, there were small decreases in phosphatidylethanolamine, phosphatidylcholine, and diphosphatidylglycerol, a small increase in sphingomyelin and a striking increase of bis(monscylglyceryl)phosphate from 2.5 to 55 mug. of P per gm. of fresh weight. Cerebrosides were also increased. In rats allowed  2 weeks to recover, values for those classes which had been decreased by the treatment showed a trend of return toward controls. These observations suggest that lysosomal material is transferred from hepatocytes to Kupffer cells.
D000818:Animals; D004163:Diphosphoglyceric Acids / Q000378:metabolism; D008099:Liver / Q000032:analysis / Q000187:drug effects* / Q000378:metabolism; D008247:Lysosomes / Q000378:metabolism; D008297:Male; D010743:Phospholipids / Q000032:analysis*; D011092:Polyethylene Glycols / Q000494:pharmacology*; D000644:Quaternary Ammonium Compounds / Q000494:pharmacology*; D051381:Rats
D004163:Diphosphoglyceric Acids; D010743:Phospholipids; D000644:Quaternary Ammonium Compounds; D011092:Polyethylene Glycols