Effect of D-glucosamine and D-galactosamine on the uridine nucleotide concentration in mouse myeloid tumor (Graffi) and myeloma MOPC-21.
The effect of D-glucosamine and D-galactosamine on the content of uridine nucleotides in myeloid tumor (Graffi) and myeloma MOPC-21 of mice was investigated in vivo. After treatment with aminosugars a marked decrease in UTP and UDP-glucose quantity was found. The trapping of uridine phosphates by formation of UDP-sugar derivatives was different in the two tumors and depended on the aminosugar employed. D-glucosamine provoked an increase in the UDP-N-acetylglucosamine pool size in myeloid tumor (Graffi) and myeloma MOPC-21. D-galactosamine administration led to formation of UDP-galactosamine and UDP-N-acetylglucosamine in myeloma MOPC-21, while in myeloid tumor (Graffi) an increase in the content of UDP-N-acetylglucosamine was obtained only.
D000818:Animals; D004273:DNA, Neoplasm / Q000378:metabolism; D005688:Galactosamine / Q000494:pharmacology*; D005944:Glucosamine / Q000494:pharmacology*; D051379:Mice; D008807:Mice, Inbred BALB C; D009101:Multiple Myeloma / Q000378:metabolism*; D009368:Neoplasm Transplantation; D009374:Neoplasms, Experimental; D009711:Nucleotides / Q000378:metabolism*; D010954:Plasmacytoma / Q000378:metabolism*; D012334:RNA, Neoplasm / Q000378:metabolism; D014184:Transplantation, Homologous; D014500:Uracil Nucleotides / Q000378:metabolism; D014529:Uridine / Q000378:metabolism*
D004273:DNA, Neoplasm; D009711:Nucleotides; D012334:RNA, Neoplasm; D014500:Uracil Nucleotides; D005688:Galactosamine; D005944:Glucosamine; D014529:Uridine