Test systems for assessing mutagenic potential of chemical substances.
The first report that certain chemicals have the potential of inducing heritable effects (mutation) appeared in the mid-1940's. Two decades passed before this and subsequent observations were translated into a concern that some of the chemicals to which we are exposed may constitute a hazard to man's genetic material and hence a threat to future generations of individuals. Such concern has led to the gradual evolution of the newest subdiscipline of toxicology, genetic toxicology. This subdiscipline is still young and faces many challenges in terms of developing sound toxicologic approaches for meeting specific evaluation needs in the interest of public health. This paper describes the current status of efforts in genetic toxicology and the types of steps which must be taken in order to begin to meet the needs and requirements of regulatory agencies.
D001711:Biotransformation; D004247:DNA / Q000502:physiology; D005069:Evaluation Studies as Topic; D005809:Genes, Regulator; D005815:Genetic Code; D005826:Genetics, Medical; D006801:Humans; D009153:Mutagens / Q000592:standards; D014116:Toxicology
D009153:Mutagens; D004247:DNA