Isolation and characterization of a gamma-thiochromanone-4-thiosemicarbazone-resistant mutant of vaccinia virus.
gamma-Thiochromanone-4-thiosemicarbazone (TCT) inhibits the growth of vaccinia virus in BSCl cells by interfering with viral maturation. A mutant of the virus (TCT(R)) which is resistant to this drug was isolated. This mutant also exhibits resistance to another thiosemicarbazone related compound, isatin beta-thiosemicarbazone (IBT). There is a good correlation between the cross-resistance of the two mutants IBT(R) and TCT(R) to TCT and IBT, respectively, and the similar antipoxvirus activity of these two thiosemicarbazone-related compounds.
D001578:Benzopyrans / Q000494:pharmacology*; D002839:Chromans / Q000494:pharmacology*; D004352:Drug Resistance, Microbial; D006801:Humans; D009154:Mutation; D013455:Sulfur; D013882:Thiosemicarbazones / Q000494:pharmacology*; D014616:Vaccinia virus / Q000187:drug effects* / Q000276:immunology / Q000302:isolation & purification; D014764:Viral Proteins / Q000096:biosynthesis
D001578:Benzopyrans; D002839:Chromans; D013882:Thiosemicarbazones; D014764:Viral Proteins; D013455:Sulfur