The effect of locally administered PGF2alpha on the contractility of the nonpregnant human uterus.
The effect of locally administered prostaglandin F2alpha on the sensitivity and reactivity of the nonpregnant human uterus during the menstrual cycle was studied. An increase in uterine contractility in response to as little as 1.0 MUG PGF2alpha could be observed in all patients during both the early and late portions of the menstrual cycle, but at the time of ovulation a marked decrease in sensitivity was noted. Endogenous prostaglandin normally occurs in the secretory endometrium in levels compatible with the amount of exogenous prostaglandin which elicited increased uterine activity. These findings support the hypothesis that PGF2alpha plays an important physiological role in the cyclical regulation of uterine motility during the human menstrual cycle.
D004305:Dose-Response Relationship, Drug; D005260:Female; D006801:Humans; D008598:Menstruation; D010060:Ovulation; D011460:Prostaglandins F / Q000008:administration & dosage / Q000494:pharmacology*; D013268:Stimulation, Chemical; D014590:Uterine Contraction / Q000187:drug effects*
D011460:Prostaglandins F