Chronic heparin anticoagulant in dogs by continuous infusion with a totally implantable pump.
The ability of our implantable pump to provide continuous long-term drug infusion in abulatory animals has been demonstrated. Chronic heparinization has been achieved in the dog for 6 mos. Anticipated complications, hemorrhage and osteoporosis occurred, but not to a prohibitive degree. The successful performance of the pump in these animal studies has led us to plan a clinical trial using the pump for heparin anticoagulation in patients and to investigate employment of the pump in cancer chemotherapy, insulin for the treatment of diabetes, and other purposes.
D000818:Animals; D001777:Blood Coagulation / Q000187:drug effects; D001842:Bone and Bones / Q000378:metabolism; D004285:Dogs; D005069:Evaluation Studies as Topic; D005260:Female; D006470:Hemorrhage / Q000209:etiology; D006493:Heparin / Q000008:administration & dosage* / Q000009:adverse effects / Q000494:pharmacology; D007263:Infusions, Parenteral / Q000295:instrumentation*; D008903:Minerals / Q000378:metabolism; D013997:Time Factors
D008903:Minerals; D006493:Heparin