Elevated serum growth hormone in protein-deprived rats, and decreased liver RNA after hypophysectomy.
Serum growth hormone was significantly higher in rats fed on a non-protein than on a 25% casein diet. In both dietary groups, hypophysectomy provoked a decrease in the RNA/DNA ratio of the liver, and, especially in the protein-deprived rats, a decrease in the RNA synthesis per liver cell, measured as the product of the RNA/DNA ratio, and the ratio of specific RNA activity to specific nucleotide activity, two hours after administration of [3H]orotic acid. In the protein-deprived rats, full reconstitution of these figures was obtained with a combination of growth hormone, hydrocortisone and triiodothyronine, but not quite with growth hormone alone. The possible role of growth hormone in protein deprivation is discussed.
D000818:Animals; D001798:Blood Proteins / Q000378:metabolism; D001835:Body Weight; D002364:Caseins / Q000494:pharmacology; D004247:DNA / Q000378:metabolism; D004044:Dietary Proteins / Q000494:pharmacology; D013006:Growth Hormone / Q000097:blood* / Q000494:pharmacology; D007016:Hypophysectomy; D008099:Liver / Q000378:metabolism*; D008297:Male; D010902:Pituitary Gland / Q000502:physiology*; D011488:Protein Deficiency / Q000378:metabolism*; D012313:RNA / Q000378:metabolism*; D051381:Rats; D013552:Swine
D001798:Blood Proteins; D002364:Caseins; D004044:Dietary Proteins; D012313:RNA; D013006:Growth Hormone; D004247:DNA