Nephrotoxicity and molecular structure.
The nephrotoxicity of a number of aminophenols, quinols and catechols has been assessed from the extent of necrosis of proximal convoluted tubules produced by intravenous injection  in rats, and the toxicity correlated with the oxidation-reduction potentials of the compounds.
D000814:Aniline Compounds / Q000633:toxicity*; D000818:Animals; D002396:Catechols / Q000633:toxicity; D005260:Female; D006873:Hydroquinones / Q000633:toxicity; D007687:Kidney Tubules, Proximal / Q000187:drug effects* / Q000473:pathology; D009336:Necrosis / Q000139:chemically induced; D010084:Oxidation-Reduction; D010636:Phenols / Q000633:toxicity; D051381:Rats; D013329:Structure-Activity Relationship
D000814:Aniline Compounds; D002396:Catechols; D006873:Hydroquinones; D010636:Phenols