The effect of chlorpromazine on the secretion of immunoreactive beta-MSH and prolactin in man.
The effect of chlorpromazine (50 mg. im) on the plasma concentration of immunoreactive beta-melanocyte-stimulating hormone (beta-MSH) and prolactin was studied in 8 hospitalized subjects with non-endocrine skin disorders. Plasma beta-MSH concentrations remained unchanged over a period of 7 h in 6 subjects. In the remaining 2 subjects there was a slight increase. Plasma prolactin concentrations were greatly increased in all subjects 1 1/2-3 h after the injection and had almost returned to pre-injection levels by 7 h. This suggests that the control of beta-MSH secretion in man, unlike that of prolactin in man and MSH peptides in other mammals, is not predominantly inhibitory. The reason for this discrepancy may be that beta-MSH is not a natural MSH in man and occurs as part of the lipotropic hormone (LPH) or as a breakdown product.
D002746:Chlorpromazine / Q000494:pharmacology*; D005260:Female; D006801:Humans; D008297:Male; D009074:Melanocyte-Stimulating Hormones / Q000097:blood* / Q000276:immunology; D010902:Pituitary Gland / Q000187:drug effects / Q000503:physiopathology*; D010903:Pituitary Gland, Anterior / Q000187:drug effects / Q000503:physiopathology; D011388:Prolactin / Q000097:blood* / Q000276:immunology; D012871:Skin Diseases / Q000097:blood; D013997:Time Factors
D011388:Prolactin; D009074:Melanocyte-Stimulating Hormones; D002746:Chlorpromazine