A genetic analysis of morphine-induced running and analgesia in the mouse.
A genetic analysis of morphine-induced analgesia and activity was conducted in mice belonging to the strains BALB/cJ, C57BL/6J, DBA/2J and to their F1 and backcross progenies. The results support previous findings showing that a negative correlation is evident between these two behavioral measures and support that their mode of inheritance is characterized by dominance or partial dominance. The biometric analysis conducted on the parental, F1 hybrid and backcross populations indicates very clearly that the effects of morphine are genetically determined.
D000698:Analgesia; D000818:Animals; D001699:Biometry; D003433:Crosses, Genetic; D005799:Genes, Dominant; D006824:Hybridization, Genetic; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D008810:Mice, Inbred C57BL; D008811:Mice, Inbred DBA; D009020:Morphine / Q000494:pharmacology*; D009043:Motor Activity / Q000187:drug effects*
D009020:Morphine