Single-dose treatment of gonorrhoea with cotrimoxazole. A report on 1,223 cases.
1,223 ambulant patients with gonorrhoea were each treated with a single dose of eight tablets of cotrimoxazole. 1,069 patients were followed up (794 males and 275 females). Of these, only 46 (4%) failed to respond. Cotrimoxazole in the dosage used was well tolerated by all the patients, with very few side-effects. There was clear evidence that cotrimoxazole did not mask concomitant syphilitic infections; neither did it produce a gonococcal carrier state. The incidence of post-gonococcal non-specific urethritis was 6 per cent. At present cotrimoxazole seems to be the most useful alternative to penicillin in the treatment of gonorrhoea.
D000293:Adolescent; D000328:Adult; D002353:Carrier State; D004338:Drug Combinations; D005260:Female; D006069:Gonorrhea / Q000188:drug therapy*; D006801:Humans; D008297:Male; D008826:Microbial Sensitivity Tests; D013420:Sulfamethoxazole / Q000008:administration & dosage / Q000627:therapeutic use*; D014295:Trimethoprim / Q000008:administration & dosage / Q000627:therapeutic use*
D004338:Drug Combinations; D014295:Trimethoprim; D013420:Sulfamethoxazole