Analgesics. 3. Selected 1-substituted and 1,3-disubstituted 5-propionoxy-5-(1-phenylethyl)barbituric acids.
Several 1,3-disubstituted and 1-substituted derivatives of 5-propionoxy-5-(1-phenylethyl)barbituric acid were synthesized and evaluated for analgesic activity.  Three of these compounds, 1,3-bis(methoxymethyl)-5-propionoxy-5-(1-phenylethyl)barbituric acid (2), 1,3-dimethyl-5-propionoxy-5-(1-phenylethyl)barbituric acid (7), and 1-methyl-5-propionoxy-5-(1-phenylethyl)barbituric acid (10), exhibited better oral activity than codeine sulfate.
D000700:Analgesics / Q000138:chemical synthesis* / Q000494:pharmacology / Q000633:toxicity; D000818:Animals; D001463:Barbiturates / Q000138:chemical synthesis* / Q000494:pharmacology / Q000633:toxicity; D002490:Central Nervous System / Q000187:drug effects; D003864:Depression, Chemical; D007928:Lethal Dose 50; D008297:Male; D051379:Mice; D013268:Stimulation, Chemical
D000700:Analgesics; D001463:Barbiturates