The comparative efficacy of diamphenethide and rafoxanide against fasciola gigantica in sheep.
Efficacy of diamphenethide ("Coriban", Burroughs Wellcome) and rafoxanide ("Ranide", Merck Sharpe & Dohme, Ltd.) was evaluated in lambs against 8-week old experimentally induced Fasciola gigantica infection. Results were assessed by the reduction in worm counts at post-mortem examination 8 weeks after treatment. Diamphenethide at a dosage rate of 100 mg/kg body weight was found 99.4 per cent effective. Rafoxanide at a dosage rate of 10 mg/kg body weight showed 98.78 per cent efficacy. Six weeks following treatment, infected animals treated with either drug exhibited significantly greater weight gain than the non-treated infected animals.
D000083:Acetanilides / Q000031:analogs & derivatives*; D000818:Animals; D003957:Diamfenetide / Q000627:therapeutic use*; D005211:Fascioliasis / Q000188:drug therapy / Q000662:veterinary*; D008099:Liver / Q000469:parasitology; D010270:Parasite Egg Count; D011888:Rafoxanide / Q000627:therapeutic use*; D012457:Salicylamides / Q000627:therapeutic use*; D012756:Sheep; D012757:Sheep Diseases / Q000188:drug therapy*
D000083:Acetanilides; D012457:Salicylamides; D011888:Rafoxanide; D003957:Diamfenetide