3-Hydroxymethyl-s-triazolo[3,4-a]phthalazine, a novel urinary hydralazine metabolite in man.
The elucidation of the structure of a new major metabolic product of hydralazine, 3-hydroxymethyl-s-triazolo[3,4-a]-phthalazine, is described. The structures of several other previously described metabolites of the drug, phthalazone, s-triazolo[3,4-a]phthalazine, and 3-methyl-s-triazolo[3,4-a]phthalazine, are confirmed. A metabolic pathway of hydralazine is also proposed.
D006801:Humans; D006830:Hydralazine / Q000378:metabolism*; D006973:Hypertension / Q000652:urine; D013058:Mass Spectrometry; D010793:Phthalazines / Q000138:chemical synthesis* / Q000652:urine; D011724:Pyridazines / Q000138:chemical synthesis*; D014230:Triazoles / Q000138:chemical synthesis / Q000652:urine
D010793:Phthalazines; D011724:Pyridazines; D014230:Triazoles; D006830:Hydralazine