Acetylcholinesterase inactivation in young and old human red blood cells.
A comparison is made of the effects of certain enzyme-inactivating agents on the acetylcholinesterase (ACHE) of young and old human erythrocytes. Normal red cells and ACHE-deficient red cells are separated in accordance with their density and then exposed to trypsin, cephalothin and tannic acid. The ACHE activity of young and old cells is affected to the same extent, indicating that inactivation is independent of cullular age and the initial enzyme activity.
D000109:Acetylcholine / Q000378:metabolism; D000328:Adult; D002469:Cell Separation; D002512:Cephalothin / Q000494:pharmacology; D002800:Cholinesterase Inhibitors; D003720:Densitometry; D004905:Erythrocyte Aging; D004912:Erythrocytes / Q000201:enzymology*; D005260:Female; D006452:Hemoglobinometry; D006801:Humans; D007202:Indicators and Reagents; D007231:Infant, Newborn; D011247:Pregnancy; D013634:Tannins / Q000494:pharmacology; D014357:Trypsin / Q000494:pharmacology
D002800:Cholinesterase Inhibitors; D007202:Indicators and Reagents; D013634:Tannins; D014357:Trypsin; D000109:Acetylcholine; D002512:Cephalothin