Syntheses and tissue distribution of 99m-Tc-sulfonylureas.
Four new tolbutamide analogs were prepared and evaluated as hypoglycemics. Hypoglycemic action was observed in two members of the class, and 99m-Tc-chelates were tested as potential radiopharmaceutical imaging agents.
D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D003864:Depression, Chemical; D007004:Hypoglycemic Agents / Q000494:pharmacology; D008297:Male; D051381:Rats; D013453:Sulfonylurea Compounds / Q000138:chemical synthesis / Q000378:metabolism / Q000494:pharmacology; D013667:Technetium / Q000378:metabolism*
D001786:Blood Glucose; D007004:Hypoglycemic Agents; D013453:Sulfonylurea Compounds; D013667:Technetium