Mitigation of caffeine-induced teratogenicity in mice by prior chronic caffeine ingestion.
Pregnant A/J female mice, which had drunk tap water or a 0.05% caffeine solution for 8-19 weeks after weaning, were each injected sc with 150 or 250 mg/kg caffeine once on day 13 of gestation. After 150 mg/kg caffeine the frequencies at term of fetal death, external malformation, and subcutaneous hematomas were significantly lower in the caffeine- than water-drinking group. After 250 mg/kg caffeine the frequency of fetal death but not of malformations and hematomas was lower in the group with caffeine pretreatment. These findings were explained by assuming that long-term ingestion of caffeine induced and increased rate of degradation of caffeine administered during pregnancy.
D000014:Abnormalities, Drug-Induced / Q000517:prevention & control*; D000818:Animals; D002110:Caffeine / Q000008:administration & dosage* / Q000009:adverse effects / Q000378:metabolism; D005260:Female; D005313:Fetal Death / Q000139:chemically induced / Q000453:epidemiology; D005865:Gestational Age; D051379:Mice; D008815:Mice, Inbred Strains; D011247:Pregnancy; D011292:Premedication
D002110:Caffeine