Toxic-therapeutic ratio of sodium cyanate.
Six patients with sickle cell anemia were treated with sodium cyanate (30 mg/kg/day). In four, treatment was stopped because of definite or suspected toxicity, and no improvement was seen in the other two. Most alarming was the sudden development of peripheral motor neuropathy in a patient whose red blood cells contained less than 0.6 mols NCO-/mol of hemoglobin: six months after treatment was stopped, function had not completely returned in this patient. Safe oral dosage regimens may not be effective, but extra-corporeal treatment of sickle cells with cyanate, or other compounds, might circumvent that problem.
D000328:Adult; D000755:Anemia, Sickle Cell / Q000188:drug therapy / Q000628:therapy; D000818:Animals; D001803:Blood Transfusion; D003485:Cyanates / Q000008:administration & dosage* / Q000506:poisoning / Q000627:therapeutic use; D005260:Female; D006801:Humans; D008297:Male; D009431:Neural Conduction / Q000187:drug effects; D051381:Rats
D003485:Cyanates