Rm values of phenols. Their relationship with log P values and activity.
The experimental Rm values for a series of phenols were obtained by a reversed-phase TLC system. The extrapolation from a range of linear relationship between experimental Rm values and acetone concentration provided a set of extrapolated Rm values. This were used for studying the relationship between structure and activity in vitro and in vivo. The possibility to obtain by means of the extrapolation technique the Rm values in a standard system for serveral series of chemotherapeutic agents is pointed out.
D000818:Animals; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D002855:Chromatography, Thin Layer; D004912:Erythrocytes / Q000187:drug effects; D006461:Hemolysis / Q000187:drug effects; D007700:Kinetics; D007928:Lethal Dose 50; D051379:Mice; D008826:Microbial Sensitivity Tests; D009994:Osmolar Concentration; D010636:Phenols / Q000494:pharmacology / Q000633:toxicity; D051381:Rats; D012995:Solubility; D013210:Staphylococcus / Q000187:drug effects; D013329:Structure-Activity Relationship
D010636:Phenols