Haemophilia home infusions with dried fresh plasma.
A group of 26 haemophilic patients was successfully managed on a home infusion programme over a one-year period. Single donor units of dried fresh plasma, the coagulant activity of which was adequate to ensure haemostasis of most of the haemorrhagic episodes treated, were used. The transmission of hepatitis was kept to a minimum by careful selection of regular, known donors and by the utilisation of single donor units of plasma in preference to plasma pools. Although the programme was costly, it was less expensive than it would have been had alternate antihaemophilic products been used. The advantages and disadvantages of self-administration are discussed. No serious mishaps occurred, and the programme was considered an outstanding success by both laymen and medical personnel. Minor alterations in liver function tests were demonstrated in several of the recipients. No factor VIII inhibitors were detected.
D000914:Antibodies, Viral / Q000032:analysis; D001803:Blood Transfusion; D003365:Costs and Cost Analysis; D005169:Factor VIII / Q000627:therapeutic use; D006386:Hemagglutination Tests; D006395:Hemarthrosis / Q000628:therapy; D006467:Hemophilia A / Q000276:immunology / Q000503:physiopathology / Q000628:therapy*; D006509:Hepatitis B / Q000517:prevention & control; D006511:Hepatitis B Antigens; D006701:Home Nursing; D006801:Humans; D008111:Liver Function Tests; D008297:Male; D010949:Plasma; D012651:Self Medication; D065227:Transfusion Reaction
D000914:Antibodies, Viral; D006511:Hepatitis B Antigens; D005169:Factor VIII