The effect of intra-uterine prostaglandin F-2alpha on corpus luteum function in the human.
Prostaglandin F-2alpha (PGF-2alpha) was administered via a Foley catheter over a 12 hour period to 8 healthy volunteers awaiting laparoscopic sterilisation. The amount of PGF-2alpha infused varied between 500 mu-g and 2000 mu-g every 2 hours for 6 doses. Plasma progestins and oestradiol 17beta, and urinary estrogens and pregnanediol were assayed throughout the study period. There was no evidence of luteolysis in any patient although vaginal bleeding of varying duration occurred in all women within 36 hours of administration of PGF-2alpha.
D003338:Corpus Luteum / Q000187:drug effects*; D003864:Depression, Chemical; D004958:Estradiol / Q000097:blood; D004967:Estrogens / Q000652:urine; D005260:Female; D006801:Humans; D010060:Ovulation / Q000187:drug effects; D011276:Pregnanediol / Q000652:urine; D011372:Progestins / Q000097:blood; D011460:Prostaglandins F / Q000494:pharmacology*; D013268:Stimulation, Chemical; D013997:Time Factors
D004967:Estrogens; D011372:Progestins; D011460:Prostaglandins F; D004958:Estradiol; D011276:Pregnanediol