Effect of plasma lipid levels and obesity on tissue stores of alpha-tocopherol.
Experiments were designed to determine how varying levels of plasma lipids affect tissue deposition of alpha-tocopherol (vitamin E). Hypolipemia was induced by feeding orotic acid, and hyperlipemia was obtained using genetically obese rats. With equal dietary intakes of alpha-tocopherol, hypolipemic rats had lower plasma and tissue concentrations than rats with normal plasma lipids. An exception was liver, which due to fatty enlargement from orotic acid had more alpha-tocopherol. Hyperlipemic obese rats had plasma total lipids and alpha-tocopherol three times those of normal rats with the same intake of alpha-tocopherol. Tissue concentrations of the vitamin, however, were considerably lower in obese rats. Due to their large adipose mass, obese rats had considerably more total body alpha-tocopherol than normal rats. It was concluded that both plasma lipid levels and degree of adiposity are important factors in determining tissue deposition of alpha-tocopherol.
D000273:Adipose Tissue / Q000032:analysis; D000818:Animals; D002784:Cholesterol / Q000097:blood; D005260:Female; D008055:Lipids / Q000097:blood*; D008099:Liver / Q000032:analysis; D008297:Male; D009132:Muscles / Q000032:analysis; D009206:Myocardium / Q000032:analysis; D009765:Obesity / Q000235:genetics / Q000378:metabolism*; D009963:Orotic Acid / Q000494:pharmacology*; D051381:Rats; D013737:Testis / Q000032:analysis; D014810:Vitamin E / Q000032:analysis / Q000097:blood / Q000378:metabolism*
D008055:Lipids; D014810:Vitamin E; D009963:Orotic Acid; D002784:Cholesterol