Metabolism of 4-3-H- and 4-14-C-17alpha-ethynylestradiol 3-methyl ether (mestranol) by women.
A mixture of 4-3-H and 4-14-C-mestranol was administered orally to four women. Reactions involving position 4 were no greater than 1.7-3% of the dose as measured by liberation of 3-H into body water. The extent of de-ethynylation in vivo was no greater than 1-2% of the dose as measured by urinary estrone metabolites. Mestranol (0.7 and 0.32% of the dose), 17alpha-ethynylestradiol (6.6 and 11.3%) and 2-hydroxy-17alpha-ethynylestradiol (0.64 and 0.7%) were identified as metabolite aglycons by reverse isotope dilution after Ketodase hydrolysis of the urine from two of the women.
D000284:Administration, Oral; D000328:Adult; D001827:Body Height; D001835:Body Weight; D002250:Carbon Radioisotopes; D004970:Estrone / Q000652:urine; D004997:Ethinyl Estradiol / Q000652:urine; D005260:Female; D006801:Humans; D007553:Isotope Labeling; D008656:Mestranol / Q000008:administration & dosage / Q000378:metabolism*; D009640:Norethindrone; D013997:Time Factors; D014316:Tritium
D002250:Carbon Radioisotopes; D014316:Tritium; D004970:Estrone; D004997:Ethinyl Estradiol; D008656:Mestranol; D009640:Norethindrone