Magnesium movement in hypothyroid sheep.
We described magnesium transport in hypothyroid and normal sheep with an eight-compartment biomodel fitted by a least-squares technique to data from multiple compartments and routes of entry of 28-Mg. Isotopic equilibrium was not attained during this period of observation in hypothyroid or control sheep. Hypothyroidism reduced transfer coefficients for absorption (P less than 0.01) of 28-Mg from the GI tract but did not change the rate coefficient for endogenous 28-Mg losses to feces (P less than 0.05). Nutritional balance data indicated higher absorption and retention of Mg in hypothyroid sheep, and the observed decrease in rate of passage of digestive residues suggested that mean retention time of GI tract contents had a definite effect on the availability of Mg.
D000818:Animals; D001692:Biological Transport; D004064:Digestive System / Q000378:metabolism; D005243:Feces / Q000032:analysis; D005769:Gastrointestinal Motility; D007037:Hypothyroidism / Q000378:metabolism*; D007457:Iodine Radioisotopes; D007668:Kidney / Q000378:metabolism; D008274:Magnesium / Q000378:metabolism*; D008954:Models, Biological; D012756:Sheep; D013974:Thyroxine / Q000378:metabolism
D007457:Iodine Radioisotopes; D008274:Magnesium; D013974:Thyroxine