Determination of perphenazine and its sulphoxide metabolite in human plasma after therapeutic doses by gas chromatography.
A gas chromatographic method for the determination of perphenazine (Tri-lafon) and its main metabolite in human plasma, perphenazine sulphoxide, has been developed. The procedure involves the use of an electron capture detector and permits the determination of the drug and its metabolite at concentrations down to 0.2 mug/l. This is sufficient for analyzing plasma from patients on ordinary treatment with perphenazine. Tests for specificity revealed no interference by nortriptyline or biperidine.
D001711:Biotransformation; D002849:Chromatography, Gas / Q000379:methods*; D006801:Humans; D007273:Injections, Intramuscular; D008722:Methods; D009661:Nortriptyline / Q000097:blood; D010546:Perphenazine / Q000008:administration & dosage / Q000031:analogs & derivatives / Q000097:blood*; D010880:Piperidines / Q000097:blood; D013454:Sulfoxides / Q000097:blood; D013997:Time Factors
D010880:Piperidines; D013454:Sulfoxides; D009661:Nortriptyline; D010546:Perphenazine