Glucagon stimulation of plasma renin activity in humans.
Administration of 0.2 mg of glucagon by intravenous bolus resulted in an increase in plasma renin activity (PRA) in 2 of 5 normal volunteers on their usual diet. Two of the nonresponders subsequently showed a PRA response to glucagon after sodium depletion. A lower dose of glucagon (0.01 mg) had no effect on PRA despite a 31 mg/100 ml rise in blood glucose and peak plasma glucagon of over 2000 pg/ml. In conclusion, glucagon can stimulate PRA but it is not a potent stimulator; its effect may be potentiated by sodium depletion.
D000328:Adult; D004032:Diet; D005665:Furosemide / Q000494:pharmacology; D005934:Glucagon / Q000494:pharmacology*; D006801:Humans; D007700:Kinetics; D008297:Male; D011188:Potassium / Q000494:pharmacology; D011863:Radioimmunoassay; D012083:Renin / Q000097:blood*; D012964:Sodium
D005665:Furosemide; D005934:Glucagon; D012964:Sodium; D012083:Renin; D011188:Potassium