Depression of blast transformation of peripheral leukocytes by plasma from pregnant women.
The blast transformation of peripheral leukocytes from pregnant and nonpregnant women has been studied at different time intervals with graded concentrations of phytohemagglutinin. The transformation is markedly depressed during pregnancy. Leukocytes from nonpregnant women and men show diminished transformation when cultured in a medium containing plasma from pregnant women.
D000328:Adult; D002478:Cells, Cultured; D003470:Culture Media; D003864:Depression, Chemical; D005260:Female; D006801:Humans; D007700:Kinetics; D037102:Lectins / Q000008:administration & dosage / Q000494:pharmacology; D007962:Leukocytes / Q000187:drug effects / Q000378:metabolism; D008213:Lymphocyte Activation / Q000187:drug effects; D008214:Lymphocytes / Q000502:physiology; D011247:Pregnancy; D011261:Pregnancy Trimester, First; D011262:Pregnancy Trimester, Second; D011263:Pregnancy Trimester, Third; D013936:Thymidine / Q000378:metabolism; D013997:Time Factors
D003470:Culture Media; D037102:Lectins; D013936:Thymidine