Dichotomy in response to indomethacin in UV-C and UV-B induced ultraviolet light inflammation.
In subjects irradiated with both UV-C and UV-B ultraviolet light (UVL), 10 mug of intradermal indomethacin decreased the redness in all 13 of the UV-B irradiated areas but in only 2 of 13 of the UV-C irradiated areas. Higher doses of intradermal indomethacin (50 mug and 100 mug) decreased the redness produced by UV-C irradiation in 6 subjects. It is suggested that the failure of 10 mug of indomethacin to decrease the redness of the UV-C induced inflammation, while decreasing the redness in the UV-B induced inflammation, is consistent with the possibility that prostaglandins participate in UV-B but not UV-C induced inflammation.
D000328:Adult; D004890:Erythema / Q000188:drug therapy* / Q000209:etiology; D005260:Female; D006801:Humans; D007213:Indomethacin / Q000008:administration & dosage / Q000627:therapeutic use*; D007249:Inflammation / Q000209:etiology / Q000628:therapy*; D007271:Injections, Intradermal; D008297:Male; D011453:Prostaglandins / Q000502:physiology; D011832:Radiation Injuries / Q000188:drug therapy* / Q000209:etiology; D014466:Ultraviolet Rays / Q000009:adverse effects
D011453:Prostaglandins; D007213:Indomethacin