An evaluation of the analgesia induced by morphine gamma-hydroxybutyrate.
Experiments were performed to determine 1) whether synergism existed between morphine and gamma-hydroxybutyrate in the production of analgesia and 2) the effect of each of these agents on pain-induced changes in brain amino acid content in mice. The analgetic ED50 for both agents was determined using hot plate and tail-flick procedures. The combination of one-half the ED50 of each agent produced an effect equivalent to the ED50 of either agent administered alone in the hot plate but not in the tail-flick test. Although both agents produced an unresponsiveness to noxious stimulation, only morphine prevented pain-induced alterations in brain GABA and glutamate levels.
D000613:Aminobutyrates / Q000494:pharmacology*; D000698:Analgesia; D000818:Animals; D001923:Brain Chemistry / Q000187:drug effects; D005971:Glutamates / Q000032:analysis; D006358:Hot Temperature; D008297:Male; D051379:Mice; D009020:Morphine / Q000494:pharmacology*; D011930:Reaction Time / Q000187:drug effects; D005680:gamma-Aminobutyric Acid / Q000032:analysis / Q000494:pharmacology*
D000613:Aminobutyrates; D005971:Glutamates; D005680:gamma-Aminobutyric Acid; D009020:Morphine