Drug release from a lipophilic ointment base as influenced by chain length of added surfactant.
The release of sulfathiazole and salicylic acid from white petrolatum containing ethoxylated surfactants of varying ethylene oxide chain length was evaluated by the dialysis method. The rate of release of the drugs increased with the ethylene oxide number of the added surfactant.
D001702:Biopharmaceutics; D009824:Ointments; D010577:Petrolatum; D012212:Rheology; D012459:Salicylates; D013329:Structure-Activity Relationship; D013432:Sulfathiazoles; D013501:Surface-Active Agents / Q000494:pharmacology*
D009824:Ointments; D012459:Salicylates; D013432:Sulfathiazoles; D013501:Surface-Active Agents; D010577:Petrolatum