Selective immunoglobulin a deficiency, ulcerative colitis, and gluten-sensitive enteropathy--a unique association.
A patient with selective immunoglobulin A deficiency, severe ulcerative colitis, and malabsorption had a flat jejunal mucosa demonstrated by peroral biopsy. Treatment at different times with a gluten-free diet for the jejunal lesion and corticosteroids for the ulcerative colitis, led to improvement of the malabsorption. A repeat jejunal biopsy demonstrated histological improvement of the jejunal mucosa, even though the colitis remained active. The occurrence of immunoglobulin A deficiency in a patient with ulcerative colitis and gluten-sensitive enteropathy is uncommon.
D000305:Adrenal Cortex Hormones / Q000627:therapeutic use; D001466:Barium Sulfate; D001706:Biopsy; D002446:Celiac Disease / Q000150:complications* / Q000175:diagnosis / Q000178:diet therapy; D003093:Colitis, Ulcerative / Q000150:complications* / Q000175:diagnosis / Q000628:therapy; D004406:Dysgammaglobulinemia / Q000150:complications* / Q000175:diagnosis; D004733:Enema; D005260:Female; D005983:Glutens; D006649:Histocompatibility Antigens / Q000032:analysis; D006650:Histocompatibility Testing; D006801:Humans; D007122:Immunoelectrophoresis; D007070:Immunoglobulin A; D007153:Immunologic Deficiency Syndromes / Q000150:complications*; D007583:Jejunum / Q000473:pathology; D008875:Middle Aged; D012812:Sigmoidoscopy
D000305:Adrenal Cortex Hormones; D006649:Histocompatibility Antigens; D007070:Immunoglobulin A; D001466:Barium Sulfate; D005983:Glutens