Further studies on the mechanism of rise in blood pressure and tachycardia after intraventricular administration of aconitine.
Intraventricular administration of aconitine nitrate (10 mug) consistently produced hypertension and tachycardia. Peripheral vaso-constriction due to increase in central vasomomotor tone mainly responsible for hypertension whereas stimulation of central beta-receptors with sympathoadr renal discharge responsible for tachycardia.
D000157:Aconitine / Q000008:administration & dosage / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D031841:Aconitum / Q000031:analogs & derivatives*; D000311:Adrenal Glands / Q000502:physiology; D000818:Animals; D001285:Atropine / Q000494:pharmacology; D001794:Blood Pressure / Q000187:drug effects*; D002415:Cats; D005260:Female; D006339:Heart Rate / Q000187:drug effects*; D006352:Heart Ventricles; D006892:Hydroxydopamines / Q000494:pharmacology; D007267:Injections; D008297:Male; D010643:Phenoxybenzamine / Q000494:pharmacology; D011433:Propranolol / Q000494:pharmacology; D012110:Reserpine / Q000494:pharmacology; D013116:Spinal Cord / Q000502:physiology; D013268:Stimulation, Chemical; D013747:Tetrabenazine / Q000494:pharmacology; D014630:Vagus Nerve / Q000502:physiology
D006892:Hydroxydopamines; D010643:Phenoxybenzamine; D001285:Atropine; D012110:Reserpine; D011433:Propranolol; D000157:Aconitine; D013747:Tetrabenazine