Histochemical study of gastric mucosubstances after thermal injury: correlation with endoscopic evidence of acute gastroduodenal disease.
Gastroduodenoscopy with biopsy was performed in nine patients within 5 days after major thermal injury. Biopsies were evaluated by special histochemical techniques to visualize and differentiate cellular mucosubstances. Acute gastroduodenal lesions were encountered early and frequently in 78% of adult burn patients. The early occurrence, morphology, and histology of these lesions suggest that alterations in gastric mucosal blood flow may play an important etiologic role. A decreased production of gastric mucus does not appear to be an etiologic factor since acute gastric mucosal disease was encountered in most patients despite normal quantities of cellular mucosubstances.
D000208:Acute Disease; D000293:Adolescent; D000328:Adult; D002056:Burns / Q000150:complications*; D004378:Duodenal Diseases / Q000209:etiology* / Q000378:metabolism / Q000473:pathology; D004724:Endoscopy; D005753:Gastric Mucosa / Q000378:metabolism / Q000473:pathology*; D005773:Gastroscopy; D006801:Humans; D008297:Male; D009093:Mucus / Q000378:metabolism; D013272:Stomach Diseases / Q000209:etiology* / Q000378:metabolism / Q000473:pathology