Hybridization of polymers of antibiotic C-nucleoside phosphates, poly(formycin phosphate) and poly(laurusin phosphate)
The ability of complex formation of poly-(formycin phosphate), poly(F), and poly(laurusin phosphate), poly(L), with the polymers of natural polynucleotides was examined mainly by mixing experiments in 0.1 M NaCl-0.05 M sodium cascodylate buffer (pH 7.0) at 2 degrees. Poly(F) formed complexes with poly(U) and poly(I) in the ratio of 1:1 and 1:2, respectively. Poly(L) formed complexes with poly(A) in 2:1 ration and poly(C) in 1:2 and 2:1 ratios in addition to a self-complex. Poly(F) and poly(L) also formed a 1:2 complex between them. Some of these complexes were assumed to contain novel types of base pairings using the 7-NH group. Thus it was concluded that poly(L) could form complexes with both, the oligomer of cycloadenylic acid (øcn-120 degrees) and polymers of natural nucleotides (øcn0degrees), showing flexibility of the torsion angle of the laurusin residue.
D000249:Adenosine Monophosphate; D000903:Antibiotics, Antineoplastic; D055598:Chemical Phenomena; D002621:Chemistry; D003597:Cytosine Nucleotides; D005573:Formycins / Q000032:analysis; D007292:Inosine Nucleotides; D009690:Nucleic Acid Conformation; D011072:Poly U; D011119:Polynucleotides
D000903:Antibiotics, Antineoplastic; D003597:Cytosine Nucleotides; D005573:Formycins; D007292:Inosine Nucleotides; D011119:Polynucleotides; D011072:Poly U; D000249:Adenosine Monophosphate