Pharmacology of local anaesthetic agents. Pharmacokinetics of local anaesthetic agents.
Information derived from measurements of blood concentrations of local anaesthetics can be extended by the application of pharmacokinetic anaylsis. A better understanding of quantitative aspects of the disposition and absorption of these drugs should assist the anaesthetist in deciding the optimal agent and dosage for regional block techniques.
D000042:Absorption; D000083:Acetanilides / Q000031:analogs & derivatives; D000779:Anesthetics, Local / Q000008:administration & dosage / Q000097:blood / Q000378:metabolism*; D002045:Bupivacaine / Q000008:administration & dosage / Q000097:blood / Q000378:metabolism; D005021:Ethylamines / Q000378:metabolism; D007700:Kinetics; D008012:Lidocaine / Q000008:administration & dosage / Q000097:blood / Q000378:metabolism; D008099:Liver / Q000378:metabolism; D008619:Mepivacaine / Q000378:metabolism; D008657:Metabolic Clearance Rate; D011437:Propylamines / Q000378:metabolism; D013997:Time Factors
D000083:Acetanilides; D000779:Anesthetics, Local; D005021:Ethylamines; D011437:Propylamines; D008012:Lidocaine; D008619:Mepivacaine; D002045:Bupivacaine