Studies on the evaluation of the toxicity of various salts of lead, manganese, platinum, and palladium.
Preliminary studies have been conducted on various parameters in order to assess the possible and relative toxicities of a number of metallic salts. Upon oral administration in lethal-dose experiments, two soluble Pt4+ salts were more toxic than the other salts tested. Following intraperiotneal injection in lethal-dose experiments, PbCl2 was less toxic than several of the soluble or partially soluble salts of Pt4+, Pd2+, and Mn2+. An intake of a total of approximately 250 mg of Pt4+ per rat in the drinking fluid over a 30-day interval did not affect the activities of aniline hydroxylase and aminopyrine demethylase in rat liver microsomes. In rats receiving soluble Pt4+ salts in the drinking fluid, the highest concentration of Pt was found in the kidney and an appreciiable concentration was found in the liver.
D000284:Administration, Oral; D000633:Aminopyrine N-Demethylase / Q000378:metabolism; D000815:Aniline Hydroxylase / Q000378:metabolism; D000818:Animals; D004032:Diet; D007274:Injections, Intraperitoneal; D007668:Kidney / Q000378:metabolism; D007854:Lead / Q000008:administration & dosage / Q000633:toxicity*; D007928:Lethal Dose 50; D008099:Liver / Q000201:enzymology / Q000378:metabolism; D008297:Male; D008345:Manganese / Q000008:administration & dosage; D020149:Manganese Poisoning; D010165:Palladium / Q000008:administration & dosage / Q000633:toxicity*; D010984:Platinum / Q000008:administration & dosage / Q000633:toxicity*; D051381:Rats; D013154:Spleen / Q000378:metabolism
D007854:Lead; D008345:Manganese; D010984:Platinum; D010165:Palladium; D000815:Aniline Hydroxylase; D000633:Aminopyrine N-Demethylase