Effect of quinestrol on plasma and urinary gonadotropins of postmenopausal women.
Ten postmenopausal women were given a 4-mg load of quinestrol by mouth and plasma FSH and LH were serially determined at monthly intervals. By bioassay, total urinary gonadotropins were also measured at the same times. Plasma FSH and apparent total gonadotropin levels in the urine were depressed to very low levels up to 3 months, while plasma LH was slightly affected. Tentative explanations of this discrepancy are presented.
D000284:Administration, Oral; D005260:Female; D005640:Follicle Stimulating Hormone / Q000097:blood*; D006801:Humans; D007986:Luteinizing Hormone / Q000097:blood*; D008593:Menopause / Q000187:drug effects*; D008875:Middle Aged; D009651:Norpregnatrienes / Q000494:pharmacology*; D011800:Quinestrol / Q000008:administration & dosage / Q000494:pharmacology*; D013997:Time Factors
D009651:Norpregnatrienes; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone; D011800:Quinestrol