Glycopyrrolate in 99mTc-pertechnetate brain imaging.
Glycopyrrolate, a synthetic anticholinergic agent, was administered parenterally to two groups of patients referred for 99mTc-pertechnetate brain imaging to assess its ability to suppress pertechnetate uptake by the choroid plexus, oral mucosa, and salivary (parotid) glands. Pertechnetate activity was almost completely eliminated from the choroid plexus and mouth and appeared to be moderately reduced in the parotid gland. The drug can be given orally and may prove valuable in pertechnetate brain imaging.
D001921:Brain; D001927:Brain Diseases / Q000175:diagnosis; D002831:Choroid Plexus / Q000378:metabolism; D006024:Glycopyrrolate / Q000494:pharmacology; D006801:Humans; D009061:Mouth Mucosa / Q000378:metabolism; D010306:Parotid Gland / Q000378:metabolism; D011759:Pyrrolidines; D011877:Radionuclide Imaging; D013667:Technetium / Q000378:metabolism*
D011759:Pyrrolidines; D013667:Technetium; D006024:Glycopyrrolate