Influence of 3-chloropropane-1,2-diol on microbial lipid composition and its effect on the activity of some antibacterial agents.
The organisms E. coli, S. aureus, K. aerogenes, Pr. vulgaris and S. abortusovis were inhibited by 3-chloropropane-1,2-diol at high concentrations (ca 10,000 mug/ml) and Ps. aeruginosa was unaffected. The phospholipid and lipoamino acid composition of E. coli, S. aureus and S. cerevisiae was altered by growth in the presence of 3-chloropropane-1,2-diol. The effect of growth under these conditions on the sensitivity of the bacteria to various antibacterial agents was determined and appears to depend on the hydrophobicity of the drug molecule. Cell division of E. coli and S. aureus was impaired by growth in the presence of 3-chloropropane-1,2-diol leading to filamentous forms. The change in phospholipid composition of both Gram-positive and Gram-negative organisms may influence cell division and antibiotic sensitivity.
D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects / Q000254:growth & development / Q000378:metabolism*; D002462:Cell Membrane / Q000187:drug effects / Q000378:metabolism; D004357:Drug Synergism; D005990:Glycerol / Q000378:metabolism; D006017:Glycolipids / Q000096:biosynthesis; D008055:Lipids / Q000096:biosynthesis*; D010743:Phospholipids / Q000096:biosynthesis; D011409:Propylene Glycols / Q000494:pharmacology*; D013045:Species Specificity
D000900:Anti-Bacterial Agents; D006017:Glycolipids; D008055:Lipids; D010743:Phospholipids; D011409:Propylene Glycols; D005990:Glycerol