Modest radiosensitization of solid tumours in C3H mice by the hypoxic cell radiosensitizer NDPP.
The x-ray dose required to cure half the mice bearing first generation transplanted mammary carcinomata 150 days after irradiation was determined. NDPP proved to be a relatively poor radiosensitizer in mice, for although a maximum enhancement ratio of 1-3 was obtained when x-rays produced from a 1-4 MeVp electron accelerator were given between 10 and 17 min after the administration of NDPP, this was at a drug concentration sufficient to cause marked kidney abnormalities in 5-10% of the mice.
D000818:Animals; D004307:Dose-Response Relationship, Radiation; D005260:Female; D007674:Kidney Diseases / Q000139:chemically induced; D008297:Male; D008325:Mammary Neoplasms, Experimental / Q000532:radiotherapy*; D051379:Mice; D008809:Mice, Inbred C3H; D009362:Neoplasm Metastasis; D009574:Nitro Compounds; D010100:Oxygen; D011427:Propiophenones / Q000494:pharmacology* / Q000633:toxicity; D011838:Radiation-Sensitizing Agents
D009574:Nitro Compounds; D011427:Propiophenones; D011838:Radiation-Sensitizing Agents; C021225:4-nitro-3-dimethylaminopropiophenone; D010100:Oxygen