[Effect of prolonged feeding of glucose to rats on the levels of sugar and insulin in the blood and the activity of key glycolysis enzymes in the liver].
A study was made of the effect of food with a high glucose content given to albino rats for a long time on blood sugar and insulin.  Changes in the activity of hexokinase and pyruvickinase in the liver were also investigated.  Food with a high glucose content given to rats for 90--100 days led to an increase in the blood sugar and insulin level.  The activity of hexokinase and pyruvickinase rose markedly by the 40th--60th day of feeding, and fell to the initial level by the 80th--90th day.  Thus, in case of a prolonged action of insulin on the organism as a result of prolonged stimulation of the insular apparatus of the pancreas by glucose there developed signs of peculiar insulin-resistance.
D000818:Animals; D001786:Blood Glucose; D004040:Dietary Carbohydrates; D005947:Glucose; D006019:Glycolysis / Q000187:drug effects; D006593:Hexokinase / Q000378:metabolism*; D007328:Insulin / Q000097:blood*; D007333:Insulin Resistance; D008099:Liver / Q000187:drug effects / Q000201:enzymology*; D008297:Male; D011770:Pyruvate Kinase / Q000378:metabolism*; D051381:Rats; D013997:Time Factors
D001786:Blood Glucose; D004040:Dietary Carbohydrates; D007328:Insulin; D006593:Hexokinase; D011770:Pyruvate Kinase; D005947:Glucose
Vliianie prodolzhitel'nogo skarmlivaniia gliukozy krysam na soderzhanie sakhara i insulina v krovi i aktivnost' kliuchevykh fermentov glikoliza v pecheni