[Competitive inhibition of Phe: tRNA ligase of sheep embryos by aurintricarboxylic acid].
Aurin tricarboxylic acid (A.T.A.), an inhibitor of protein biosynthesis (initiation and elongation steps), acts also as a competitive inhibitor of phenylalanine, in the ATP-PPi exchange and tRNAPhe aminoacylation reactions catalysed by cytoplasmic wheat germ phenylalanine:tRNA ligase.
D000604:Amino Acyl-tRNA Synthetases / Q000037:antagonists & inhibitors*; D001312:Aurintricarboxylic Acid / Q000494:pharmacology*; D003509:Cyclohexanecarboxylic Acids / Q000494:pharmacology*; D003593:Cytoplasm / Q000201:enzymology; D007700:Kinetics; D010652:Phenylalanine-tRNA Ligase / Q000037:antagonists & inhibitors*; D010944:Plants / Q000201:enzymology*; D046249:Transfer RNA Aminoacylation / Q000187:drug effects; D014908:Triticum / Q000201:enzymology
D003509:Cyclohexanecarboxylic Acids; D001312:Aurintricarboxylic Acid; D000604:Amino Acyl-tRNA Synthetases; D010652:Phenylalanine-tRNA Ligase
Inhibition competitive de la PHE: tRNA ligase des embryons de ble par l'acide aurine tricarboxylique