Measurement of glomerular filtration rate by fluorescent excitation of non-radioactive meglumine iothalamate.
The clearance of non-radioactive meglumine Iothalamate (Conray 60), assayed by fluorescent excitation analysis, has been shown to be a good indicator of the glomerular filtration rate (GFR). Investigations in rats by the constant infusion technique showed a good correlation with insulin clearance. In a group of ten children and one adult, we obtained excellent agreement between GFR determinations by clearance of Conray 60 and I-125 sodium Iothalamate, using the single injection technique, and taking samples from 10 min to 4 hr after injection. The decay curve was resolved into two exponential components. We have also shown that the 3 and 4 hr samples, fitted to a single exponential function, yield good agreement with GFR determinations using a double exponential model. The GFR determination method presented here is accurate, simple, cost effective, and involves no radiation exposure to the patient.
D000328:Adult; D000818:Animals; D002648:Child; D005453:Fluorescence; D005919:Glomerular Filtration Rate; D006801:Humans; D007263:Infusions, Parenteral; D007275:Injections, Intravenous; D007444:Inulin; D007482:Iothalamate Meglumine / Q000008:administration & dosage; D007483:Iothalamic Acid / Q000031:analogs & derivatives*; D008297:Male; D051381:Rats; D013997:Time Factors
D007483:Iothalamic Acid; D007444:Inulin; D007482:Iothalamate Meglumine