Hormonal disturbances and effect of pharmaca.
The hormonal milieu of the organism may exert certain influences on the activity and lasting of the effect of some drugs. This was demonstrated in female rats with the example of a steroid hormone (estrone) and a short acting barbiturate derivative (hexobarbital). Estrus produced with estrone is not to be influenced by ovariectomy. Hyperthyrosis lead to the cumulation of estrogens in active form and lengthened their effect. Hypothyrosis accelerated estrogen metabolism inducing a relatively ephemer effect of estrone. Hexobarbital metabolism is faster in ovariectomised rats as well as in thyroidectomised ones than in controls. The catatoxic effect of testosterone is bringing about a short anesthesia. Hyperthyrosis reduced the effect of hexobarbital to one fourth of the control values. A special care is necessary in administering drugs when endocrine disorders are present. Individual dosages of the pharmaca may be taken into consideration to adapt the right dosages to the hormonal disturbances.
D000818:Animals; D002369:Castration; D004305:Dose-Response Relationship, Drug; D004700:Endocrine System Diseases / Q000378:metabolism*; D004970:Estrone / Q000008:administration & dosage / Q000378:metabolism; D005260:Female; D006591:Hexobarbital / Q000008:administration & dosage / Q000378:metabolism; D006980:Hyperthyroidism / Q000378:metabolism; D004364:Pharmaceutical Preparations / Q000008:administration & dosage / Q000378:metabolism*; D051381:Rats; D013965:Thyroidectomy; D013997:Time Factors
D004364:Pharmaceutical Preparations; D004970:Estrone; D006591:Hexobarbital