Suppression of the pathogenic effects of Strongylus edentatus larvae with thiabendazole.
Four pony foals were inoculated with Strongylus edentatus infective larvae and on days 3 and 4 postinfection two of the ponies were treated with thiabendazole, each at the rate of 440 mg/kg of body weight. Total circulating eosinophil counts in untreated ponies increased to over 1700 per cu mm after the second week postinfection. In the treated ponies as well as in an uninfected untreated pony eosinophil counts did not increase beyond 100 per cu mm. At necropsy on day 35 postinfection the cecum, colon and omentum of treated ponies were normal and few tracks were present on the surface of the liver. In untreated ponies nodules were observed on the serosal surface of the cecum and right ventral colon and white foci and tracks were numerous on the surface of the liver. A total of 53 fourth stage larvac was recovered from the livers of the thiabendazole treated ponies and 1194 from the untreated ones.
D000818:Animals; D002432:Cecum / Q000473:pathology; D003106:Colon / Q000473:pathology; D004804:Eosinophils; D006736:Horses; D007814:Larva; D007958:Leukocyte Count; D008099:Liver / Q000473:pathology; D009852:Omentum / Q000473:pathology; D013319:Strongyle Infections, Equine / Q000188:drug therapy* / Q000473:pathology; D013827:Thiabendazole / Q000627:therapeutic use*
D013827:Thiabendazole