Angiotensin II stimulation of prostaglandin production in cultured human vascular endothelium.
Immunoreactive material resembling prostaglandin E accumulates in the medium of cultured human umbilical vein endothelial cells. Prodcution is inhibited by indomethacin and stimulated by angiotensin II. Prostaglandin secretion by endothelium may be important in platelet-dependent thrombotic phenomena, and in local control of vascular permeability and tone in vivo.
D000804:Angiotensin II / Q000494:pharmacology*; D002199:Capillary Permeability / Q000187:drug effects; D046508:Culture Techniques; D003864:Depression, Chemical; D004305:Dose-Response Relationship, Drug; D004727:Endothelium / Q000378:metabolism; D006801:Humans; D007213:Indomethacin / Q000494:pharmacology; D009119:Muscle Contraction / Q000187:drug effects; D009130:Muscle, Smooth / Q000187:drug effects; D011458:Prostaglandins E / Q000096:biosynthesis*; D013268:Stimulation, Chemical; D014471:Umbilical Veins / Q000378:metabolism*
D011458:Prostaglandins E; D000804:Angiotensin II; D007213:Indomethacin