Heterogeneity of rabbit platelets. IV. Thrombocytosis with absolute megathrombocytosis in phenylhydrazine-induced hemolytic anemia in rabbits.
Intravenous injection of phenylhydrazine into intact rabbits resulted in a thrombocytosis of 1.85 fold and megathrombocytosis (large platelets) of 2.30 fold. Splenectomy markedly impaired this response. The intravenous injection of red blood cell hemolysates gave a response similar to that of phenylhydrazine in both intact and splenectomized animals. Basal data obtained from intact and splenectomized animals; as well as kinetic data obtained following apparent splenic blockade secondary to phenylhydrazine hemolysis revealed the presence of a splenic platelet pool with preferential splenic sequestration of megathrombocytes. It is suggested that the thrombocytosis and absolute megathrombocytosis of hemolysis is due to splenic blockade by red blood cell hemolysate.
D000743:Anemia, Hemolytic / Q000139:chemically induced* / Q000150:complications; D000818:Animals; D001772:Blood Cell Count; D001792:Blood Platelets / Q000187:drug effects; D004912:Erythrocytes; D005260:Female; D006461:Hemolysis; D008297:Male; D008533:Megakaryocytes; D010659:Phenylhydrazines / Q000008:administration & dosage / Q000009:adverse effects*; D011817:Rabbits; D013156:Splenectomy; D013922:Thrombocytosis / Q000139:chemically induced* / Q000209:etiology
D010659:Phenylhydrazines