Investigations on the carcinogenic burden by air pollution in man. XI. About the effect of aluminiumhydroxid upon the benzo(a)pyrene carcinogenesis.
Recent publications point towards a probable influence of trace elements on the cancerogenicity of chemical substances. On the basis of these reports we chose Al(OH)3 as trace element in our experiments, trying to clarify the influence of some adjuvants of vaccines on oncogenesis as described by several authors. To female NMRI-mice we applied subcutaneously 10 mug, 50 mug, 100 mug benzo(a)pyrene respectively in 0,5 ml tricaprylin-Al(OH)3-gel mixture and compared it with similar doses of benzo(a)pyrene in 0,5 ml tricaprylin-NaCl solutions. Results of experiments: 1. Al(OH)3 considerably reduced the tumor formation in the groups, treated with 10 and 50 mug benzo(a)pyrene; even tumor rates in the 100 mug benzo(a)pyrene group were diminished but much less than by the lower doses. 2. After ninety weeks the amount of tumors in the groups treated with 10 or 50 mug benzo(a)pyrene + Al(OH)3 was significantly lower than that of their control groups. At the highest doses (100 mug) a significant difference could not be noted. 3. Mean periods of tumor induction within all groups treated with benzo(a)pyrene-Al(OH)3 were significantly prolonged in comparison to controls. 4. In experiments with subcutaneously treated mice the doses-effect-relationship is changed when Al(OH)3 corresponds to the results of experiment with atmospheric dusts or exhaustion condensates. It is still pending whether adsorbtive or other processes make this effect.
D000536:Aluminum Hydroxide / Q000627:therapeutic use*; D000818:Animals; D001580:Benzopyrenes; D004305:Dose-Response Relationship, Drug; D005260:Female; D051379:Mice; D008815:Mice, Inbred Strains; D009374:Neoplasms, Experimental / Q000139:chemically induced / Q000517:prevention & control*
D001580:Benzopyrenes; D000536:Aluminum Hydroxide