Potential central nervous system antineoplastic agents. Amides of 6-cyano-6-norlysergic acid.
A group of amides of 6-cyano-6-norlysergic acid was prepared from their corresponding lysergamides.  None of these N-cyano derivatives showed anticancer activity against lymphoid leukemia L1210 in mice.  This is in contrast to the reported in vitro anticancer activity (P-815 mastocytoma) of 6-cyano-6-norlysergic acid diethylamide.
D000818:Animals; D000970:Antineoplastic Agents / Q000138:chemical synthesis*; D004873:Ergolines / Q000138:chemical synthesis*; D007939:Leukemia L1210 / Q000188:drug therapy; D008237:Lysergic Acid / Q000031:analogs & derivatives / Q000138:chemical synthesis* / Q000627:therapeutic use; D051379:Mice; D011619:Psychotropic Drugs / Q000138:chemical synthesis* / Q000627:therapeutic use
D000970:Antineoplastic Agents; D004873:Ergolines; D011619:Psychotropic Drugs; D008237:Lysergic Acid