[The function of the isolated heterologous liver perfused with the human blood (author's transl)].
The metabolic changes and their influence on the isolated liver were studied in 21 experiments on pig liver, perfused with human blood during the period of 3 hrs. It was detected, that rather active carbohydrate and nitrogenic metabolism has been maintained in the liver during 1.5-2 hrs. But after the 2nd hr of perfusion the phenomens of perfusion the phenomens of hypoxia increased, that caused the inhibition of metabolic processes and leaded to deterioration of liver function. The experience of clinical perfusions showed, that the functional activity of assisted liver over the period of 90 min was so depressed, that the organ couldn't provide positive clinical effect.
D000818:Animals; D001769:Blood; D050260:Carbohydrate Metabolism; D006801:Humans; D000860:Hypoxia; D008099:Liver / Q000378:metabolism / Q000503:physiopathology*; D010477:Perfusion; D013552:Swine; D013997:Time Factors; D014021:Tissue Preservation
Funktion der isolierten heterogenen Leber bei ihrer Perfusion durch Menschenblut