Factor IX deficiency in the nephrotic syndrome: studies with prothrombin complex concentrate.
A patient manifesting acquired factor IX deficiency in association with the nephrotic syndrome received prothrombin complex concentrate and demonstrated an accelerated plasma disappearance rate of factors II, IX and X. Amelioration of proteinuria and the plasma coagulation defect followed therapy with corticosteroids and azathioprine.
D001379:Azathioprine / Q000627:therapeutic use; D003029:Coagulants / Q000494:pharmacology; D005170:Factor X / Q000032:analysis; D005260:Female; D002836:Hemophilia B / Q000150:complications*; D006801:Humans; D006973:Hypertension / Q000150:complications; D008875:Middle Aged; D009404:Nephrotic Syndrome / Q000150:complications*; D011241:Prednisone / Q000627:therapeutic use; D011507:Proteinuria / Q000150:complications; D011516:Prothrombin / Q000032:analysis / Q000494:pharmacology; D014812:Vitamin K / Q000627:therapeutic use
D003029:Coagulants; D014812:Vitamin K; D011516:Prothrombin; D005170:Factor X; D001379:Azathioprine; D011241:Prednisone