[Effects of practolol on A-V conduction during atrial stimulation in 50 patients with and without coronary heart disease].
Practolol was injected intravenously at 3 dose levels (5, 15 and 25 mg total dose) in patients with ischemic heart disease and in non-cardiac cases. The influence of practolol on the P-Q interval at rest and at paced rates (atrial stimulation) of 110, 125 and 140 beats/min was studied: only the 15 mg dose produced a significant prolongation of the P-Q interval of normal patients at rest and at paced rates. No significant P-Q changes were found in patients with ischemic heart disease at all dose levels. It is concluded that practolol has no measurable direct effect on A-V conduction and that patients with ischemic heart disease are not more sensitive as regards A-V conduction.
D000293:Adolescent; D000328:Adult; D000368:Aged; D006328:Cardiac Catheterization; D003327:Coronary Disease / Q000503:physiopathology*; D004305:Dose-Response Relationship, Drug; D004562:Electrocardiography; D005260:Female; D006325:Heart Atria; D006329:Heart Conduction System / Q000187:drug effects* / Q000503:physiopathology; D006439:Hemodynamics; D006801:Humans; D007275:Injections, Intravenous; D008297:Male; D008875:Middle Aged; D010138:Pacemaker, Artificial; D011217:Practolol / Q000494:pharmacology*; D012146:Rest
D011217:Practolol
Practolol-Einfluss auf die AV-Uberleitung unter Vorhofstimulation bei 50 Patienten mit un ohne koronare Herzerkrankung