Reciprocation of renin dependency with sodium volume dependency in renal hypertension.
An angiotensin II inhibitor was administered to rats with two-kidney Goldblatt hypertension. The inhibitor produced a marked drop in blood pressure after 5 weeks but no significant change after 15 weeks of hypertension. However, even after 15 weeks of hypertension, following sodium depletion by either diuretics or a low sodium diet, the animals again became renin dependent as readministration of the inhibitor induced a significant fall in blood pressure. The data indicate that two-kidney Goldblatt hypertension is initially renin dependent but subsequently becomes sodium volume dependent in a way similar, although more protracted, to that already described for one-kidney Goldblatt hypertension.
D000804:Angiotensin II / Q000037:antagonists & inhibitors / Q000097:blood; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D003864:Depression, Chemical; D004195:Disease Models, Animal; D006977:Hypertension, Renal / Q000097:blood*; D008297:Male; D051381:Rats; D012078:Renal Artery Obstruction / Q000097:blood*; D012083:Renin / Q000097:blood*; D012504:Saralasin / Q000494:pharmacology; D012964:Sodium / Q000097:blood* / Q000378:metabolism
D000804:Angiotensin II; D012964:Sodium; D012083:Renin; D012504:Saralasin