4-hydroxy-3-nitro-2-quinolones and related compounds as inhibitors of allergic reactions.
The synthesis and biological activity of a number of 4-hydroxy-3-nitro-2-quinolones are discussed and compared with their related hydroaromatic analogs.  Antiallergic activity has been assessed by their ability to inhibit the homocytotropic antibody-antigen induced passive cutaneous anaphylaxis reaction in the rat.
D000818:Animals; D006912:Hydroxyquinolines / Q000138:chemical synthesis* / Q000627:therapeutic use; D006967:Hypersensitivity / Q000188:drug therapy*; D008297:Male; D009600:Nitroquinolines / Q000138:chemical synthesis* / Q000627:therapeutic use; D010323:Passive Cutaneous Anaphylaxis; D051381:Rats; D012882:Skin Tests
D006912:Hydroxyquinolines; D009600:Nitroquinolines