Hypertension-inducing potency and renin content of variously treated kidney extract.
Kidney extract from rats which were adrenalectomized and given tap water was dialyzed, salted out, ultrafiltrated or heated. A given dose of each extract or fractionized material was administered to uninephrectomized rats subcutaneously every 12 hours for 10 days. The relationship between renin content of each sample and final blood pressure level following repeated injections as an index of its hypertension-inducing potency was analyzed. There was no apparent discrepancy between the two of each sample. No evidence was obtained for the existence of other renal substance than renin which might be implicated in producing hypertension.
D000645:Ammonium Sulfate; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D003956:Dialysis; D006358:Hot Temperature; D007022:Hypotension / Q000139:chemically induced*; D007668:Kidney; D008297:Male; D051381:Rats; D012083:Renin / Q000032:analysis*; D014020:Tissue Extracts / Q000032:analysis / Q000302:isolation & purification / Q000494:pharmacology; D014462:Ultrafiltration
D014020:Tissue Extracts; D012083:Renin; D000645:Ammonium Sulfate