Imipramine toxicity.
Clinical experience has firmly established the usefulness of imipramine in the management of enuresis. Our report describes the serious dose-related cardiac and central nervous system toxic effects of imipramine. Comparison of the human and animal toxicity data is presented and recommendations are given for safe human dose ranges.
D000818:Animals; D001145:Arrhythmias, Cardiac / Q000139:chemically induced; D002490:Central Nervous System / Q000187:drug effects*; D003128:Coma / Q000139:chemically induced; D004285:Dogs; D004305:Dose-Response Relationship, Drug; D004775:Enuresis / Q000188:drug therapy*; D006321:Heart / Q000187:drug effects*; D006801:Humans; D007099:Imipramine / Q000009:adverse effects / Q000627:therapeutic use / Q000633:toxicity*; D051381:Rats; D012131:Respiratory Insufficiency / Q000139:chemically induced
D007099:Imipramine