The relationship between nasopharyngeal carcinoma and the HL-A system among Tunisians.
Previous reports have demonstrated an association between the HL-A system and risk for nasopharyngeal carcinoma among the Chinese in Singapore. The present paper describes an investigation of HL-A profiles among NPC cases and non-NPC controls from Tunisia, to determine whether a similar association occurs in a different ethnic group. A total of 109 NPC cases and 84 controls were typed. At the second HL-A locus the results were similar to those found in Singapore, but the effect was less marked and did not reach high statistical significance. At the first HL-A locus, no association between A2 and NPC was found, in contrast to the Singapore results.
D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000368:Aged; D002648:Child; D005260:Female; D005787:Gene Frequency; D006680:HLA Antigens; D006649:Histocompatibility Antigens; D006650:Histocompatibility Testing; D006801:Humans; D008297:Male; D008875:Middle Aged; D009303:Nasopharyngeal Neoplasms / Q000453:epidemiology* / Q000235:genetics; D010641:Phenotype; D012306:Risk; D012737:Sex Factors; D014416:Tunisia
D006680:HLA Antigens; D006649:Histocompatibility Antigens