Latrogenic platelet dysfunction: an emerging peril.
Abnormal bleeding after a face lift was found to be due to a profound interference in platelet function caused by clofibrate and xylocaine acting synergistically. This did not appear to be an idiosyncratic reaction to either of the drugs, as it could be reproduced in vitro by using platelets from normal individuals. Clofibrate is a drug used commonly by persons in the age group requesting face lifts. Beware.
D001778:Blood Coagulation Disorders / Q000139:chemically induced* / Q000209:etiology; D001792:Blood Platelets / Q000187:drug effects; D002994:Clofibrate / Q000009:adverse effects / Q000494:pharmacology; D004357:Drug Synergism; D005145:Face / Q000601:surgery; D006406:Hematoma; D006801:Humans; D007049:Iatrogenic Disease; D066298:In Vitro Techniques; D008012:Lidocaine / Q000009:adverse effects / Q000494:pharmacology; D008297:Male; D008875:Middle Aged; D011183:Postoperative Complications; D013518:Surgery, Plastic / Q000009:adverse effects
D008012:Lidocaine; D002994:Clofibrate