Experimental effects of heparin or magnesium sulfate on the  patency of microvascular anastomoses.
Partial amputations of the hind legs were done in 44 rats. The femoral arteries and veins were repaired by microvascular techniques. The systemic use of heparin, the local use of magnesium sulfate, and the combined use of the two drugs, were evaluated as to their influence on preventing thrombosis in these microvascular anastomoses. No benefit could be demonstrated from the use of these drugs.
D000671:Amputation, Surgical; D000818:Animals; D001777:Blood Coagulation / Q000187:drug effects*; D004341:Drug Evaluation; D004359:Drug Therapy, Combination; D005260:Female; D006493:Heparin / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D006614:Hindlimb / Q000601:surgery; D008278:Magnesium Sulfate / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D008297:Male; D008833:Microcirculation / Q000601:surgery; D008866:Microsurgery; D051381:Rats; D013927:Thrombosis / Q000517:prevention & control*; D014656:Vascular Surgical Procedures
D008278:Magnesium Sulfate; D006493:Heparin