Studies on indomethacin acute toxicity and absorption.
Indomethacin can be found in several crystalline forms, of which only gamma is allowed in therapy. To determine the possible correlation between indomethacin crystalline form and its absorption as well as acute toxicity, a cycle of experiments was undertaken on mice and rats. Significant differences in toxic activity of alpha and gamma forms were stated in mice. In rats, however, no influence of the crystalline form on toxicity or absorption was observed.
D000818:Animals; D003460:Crystallization; D004305:Dose-Response Relationship, Drug; D005260:Female; D007213:Indomethacin / Q000008:administration & dosage / Q000378:metabolism / Q000633:toxicity*; D007408:Intestinal Absorption; D007421:Intestine, Small / Q000378:metabolism; D007928:Lethal Dose 50; D008297:Male; D051379:Mice; D010477:Perfusion; D051381:Rats; D013053:Spectrophotometry; D013329:Structure-Activity Relationship; D013997:Time Factors
D007213:Indomethacin