Anti-HL-A7 lymphocyte-dependent antibody.
Target cell specificity of a human cytotoxic lymphocyte-dependent antiserum correlated with the presence of HL-A7 on target cells. Target cells from 10 of 11 HL-A7-positive donors were damaged in vitro by this antiserum together with lymphocytes from normal donors. Target cells from six donors lacking HL-A7 were not damaged. Cytotoxic activity was removed by adsorption of the antiserum with lymphocytes from any one of four HL-A7-positive donors. Adsorption with lymphocytes from any one of three HL-A7-negative donors failed to eliminate cytotoxic activity.
D000327:Adsorption; D000906:Antibodies; D000937:Antigen-Antibody Reactions; D003601:Cytotoxicity Tests, Immunologic; D005260:Female; D006680:HLA Antigens; D006649:Histocompatibility Antigens; D006801:Humans; D007106:Immune Sera; D008214:Lymphocytes / Q000276:immunology*; D011247:Pregnancy
D000906:Antibodies; D006680:HLA Antigens; D006649:Histocompatibility Antigens; D007106:Immune Sera