Antiinflammatory beta-arylamidoacrylic acids.
A series of 34 beta-arylamidoacrylic acids was prepared and examined for antiinflammatory activity. These compounds are vinylogous carbamic acids, and several displayed activity equal to phenylbutazone in the rat pleural effusion model. Highest activity was associated with structures bearing halogen and cyano substituents. Amides were inactive.
D000179:Acrylates / Q000138:chemical synthesis* / Q000627:therapeutic use; D000577:Amides / Q000138:chemical synthesis / Q000627:therapeutic use; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000138:chemical synthesis* / Q000627:therapeutic use; D002351:Carrageenan; D004396:Coloring Agents; D007536:Isomerism; D010998:Pleurisy / Q000139:chemically induced / Q000188:drug therapy; D051381:Rats; D013237:Stereoisomerism; D013329:Structure-Activity Relationship
D000179:Acrylates; D000577:Amides; D000893:Anti-Inflammatory Agents; D004396:Coloring Agents; D002351:Carrageenan