Low-fiber intake as an etiologic factor in cancer of the colon.
A case-control dietary study of 198 patients with cancer of the colon and two matched control groups demonstrated a significantly lower fiber consumption frequency among the cancer patients. This difference was not confined to a few items. Of the 73 items on the fiber list, 61 were eaten less often by the cancer patient than by a neighborhood control, and 57 were consumed less frequently than by a surgical control. These findings support the hypothesis that low-residue foods play an etiologic role in colon carcinogenesis. A mechanism related to the possible potential carcinogenic properties of degraded biliary compounds may be implicated.
D000328:Adult; D000368:Aged; D001647:Bile Acids and Salts / Q000009:adverse effects; D003110:Colonic Neoplasms / Q000209:etiology*; D004032:Diet / Q000009:adverse effects*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010528:Peristalsis; D012004:Rectal Neoplasms / Q000209:etiology
D001647:Bile Acids and Salts