Serum and aortic lipid profiles in spontaneous and cholesterol-induced atherosclerosis in Rhesus monkeys.
Serum lipids and lipoproteins and various lipid fractions in the aorta were compared in spontaneously-occurring and cholesterol-induced atherosclerosis of rhesus monkeys. A group of 30 normal monkeys were also studied. Serum cholesterol, total phospholipid and triglyceride values in spontaneous atherosclerosis were similar to normal, but were significantly elevated in cholesterol-induced atherosclerosis. Fractionation of the major phospholipids in animals with spontaneous atherosclerosis showed increased PC with decreased LPC and SP + LPE, while PE was elevated and SP + LPE diminished in cholesterol-induced atherosclerosis. Beta-lipoproteins were markedly increased in cholesterol-induced atherosclerosis, but remained normal in spontaneous atherosclerosis. Among the aortic lipid, PC and PE were significantly elevated in spontaneous atherosclerosis, but in cholesterol-induced atherosclerosis all the neutral lipids were raised, together with a specific rise of PC and decrease of SP + LPE. These observations tend to indicate that the mechanism of atherosclerosis production in the two states greatly varies.
D000818:Animals; D001011:Aorta / Q000378:metabolism* / Q000473:pathology; D001161:Arteriosclerosis / Q000378:metabolism* / Q000473:pathology; D002784:Cholesterol / Q000097:blood; D002855:Chromatography, Thin Layer; D004036:Diet, Atherogenic; D005260:Female; D050356:Lipid Metabolism; D008055:Lipids / Q000097:blood; D008074:Lipoproteins / Q000378:metabolism; D008253:Macaca mulatta; D008297:Male; D010743:Phospholipids / Q000097:blood / Q000378:metabolism; D014280:Triglycerides / Q000097:blood / Q000378:metabolism
D008055:Lipids; D008074:Lipoproteins; D010743:Phospholipids; D014280:Triglycerides; D002784:Cholesterol