The disposition and metabolism of I.C.I. 58,834 (viloxazine) in humans.
1. 2-(2-Ethoxyphenoxymethyl)-2,3,5,6-tetrahydro-1,4-oxazine (I.C.I. 58,834) in three 14C-labelled forms, given orally to two male volunteers, was completely absorbed, extensively metabolized and rapidly eliminated via the kidney. 2. O-Dealkylation, the major metabolic pathway in the rat, was not significant in man. 3. The major component in blood at all times was I.C.I. 58,834, which had a blood half-life of 4 h. The level of 14C in blood at 31 h was near the limit of detection. 4. The observed activity of the drug appears to be due to the parent compound alone.
D000284:Administration, Oral; D000328:Adult; D000928:Antidepressive Agents / Q000378:metabolism*; D002250:Carbon Radioisotopes; D055598:Chemical Phenomena; D002621:Chemistry; D002854:Chromatography, Paper; D002855:Chromatography, Thin Layer; D005243:Feces / Q000378:metabolism; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D010078:Oxazines / Q000097:blood / Q000378:metabolism* / Q000652:urine; D013997:Time Factors
D000928:Antidepressive Agents; D002250:Carbon Radioisotopes; D010078:Oxazines