The effect of tetrabenazine on the accumulation of noradrenaline in constricted postganglionic sympathetic nerves in vitro.
The accumulation of noradrenaline proximal to a constriction applied to cat hypogastric nerves in vitro has been studied in preparations treated with tetrabenazine. The accumulation of amine was almost completely abolished by the drug. Evidence is presented which suggests that tetrabenazine exerts a direct noradrenaline-depleting effect on the intraneuronal storage vesicles. Recovery of noradrenaline levels after the removal of the drug was rapid and was effected by the biosynthesis of new noradrenaline within the axon.
D000818:Animals; D001338:Autonomic Fibers, Postganglionic / Q000187:drug effects* / Q000378:metabolism / Q000648:ultrastructure; D001369:Axons / Q000648:ultrastructure; D002415:Cats; D003594:Cytoplasmic Granules / Q000648:ultrastructure; D005260:Female; D008026:Ligation; D008297:Male; D008781:Methyltyrosines / Q000494:pharmacology; D009638:Norepinephrine / Q000378:metabolism*; D013564:Sympathetic Nervous System / Q000378:metabolism; D013747:Tetrabenazine / Q000494:pharmacology*
D008781:Methyltyrosines; D009638:Norepinephrine; D013747:Tetrabenazine