Myelination of brain in experimental hypothyroidism. An electron-microscopic and biochemical study of purified myelin isolates.
Myelin development has been studied in the neonatally hypothyroid rat brain by isolation and characterization of purified myelin preparations. The hormone deficiency results in a suppression of compact myelin formation and the persistence of a lighter possibly pro-myelin fraction. The appearance of myelin basic protein was markedly delayed in the hormone-deficient animals and this effect on the basic protein moiety may be responsible for the delayed myelinogenesis.
D000818:Animals; D000831:Animals, Newborn; D001921:Brain / Q000378:metabolism*; D001923:Brain Chemistry; D002784:Cholesterol / Q000032:analysis; D004195:Disease Models, Animal; D004589:Electrophoresis, Disc; D006017:Glycolipids / Q000032:analysis; D007037:Hypothyroidism / Q000378:metabolism*; D008854:Microscopy, Electron; D009186:Myelin Sheath / Q000032:analysis / Q000648:ultrastructure; D009419:Nerve Tissue Proteins / Q000032:analysis / Q000096:biosynthesis*; D010743:Phospholipids / Q000032:analysis; D051381:Rats
D006017:Glycolipids; D009419:Nerve Tissue Proteins; D010743:Phospholipids; D002784:Cholesterol