Effect of enamel solubility reducing agents on erosion in the rat.
Three experiments performed on Osborne-Mendel rats tested the effects on erosion of the topical application of aluminum, cerium and titanium salts as well as sodium fluoride and sodium mono-fluorophosphate. In two experiments the compounds were applied during the erosion period and in a third trial, the test substances were applied prior to exposure to the erosive agent which was fermented apple juice. While cerium had no significant effects on erosion, aluminum fhloride and titanium chloride significantly increased the severity of erosive tooth destruction. Only sodium fluoride and sodium mono-fluorophosphate were effective in preventing erosion.
D000287:Administration, Topical; D000535:Aluminum / Q000008:administration & dosage / Q000494:pharmacology*; D000818:Animals; D001628:Beverages; D002563:Cerium / Q000008:administration & dosage / Q000494:pharmacology*; D003743:Dental Enamel / Q000378:metabolism; D003747:Dental Enamel Solubility / Q000187:drug effects*; D003804:Dentin / Q000378:metabolism; D005459:Fluorides / Q000008:administration & dosage / Q000494:pharmacology*; D005638:Fruit; D010710:Phosphates / Q000008:administration & dosage / Q000494:pharmacology*; D051381:Rats; D012964:Sodium; D014025:Titanium / Q000008:administration & dosage / Q000494:pharmacology*; D014077:Tooth Erosion / Q000139:chemically induced / Q000378:metabolism*
D010710:Phosphates; D002563:Cerium; D012964:Sodium; D000535:Aluminum; D014025:Titanium; D005459:Fluorides