The effects of cosmic radiation on pocket mice aboard Apollo XVII: V. preflight studies on tolerance of pocket mice to oxygen and heat. Part IV. observations on the brain.
Experiments designed to ascertain the effects of oxgen at 8, 10, and 12 psi partial pressure on the brains of pocket mice (Perognathus longimembris) were carried out at room temperature (24 degrees C, 75 degrees F) and at 32 degrees C (93 degrees F). The animals exposed to 8-12 psi at 32 degrees C had been in earlier KO2 oxygen tests. Five animals exposed either to 10 or 12 psi (517 mm or 620 mm HG) PO2 at 32 degrees C died during the course of the tests, possibly as a consequence of injury sustained by the earlier PO2 testing. Autopsy was not carried out. In the other 36 exposed animals, no pathological changes were observed in the brain. It is thus highly probable that oxygen pressures at the hyperbaric levels to which the pocket mice would be exposed during the Apollo XVII mission would not result in any lesions in the brain.
D000222:Adaptation, Physiological; D000818:Animals; D001273:Atmosphere Exposure Chambers; D001921:Brain / Q000187:drug effects* / Q000473:pathology; D003359:Cosmic Radiation; D004780:Environment, Controlled; D006358:Hot Temperature; D051379:Mice; D010100:Oxygen / Q000633:toxicity*; D010313:Partial Pressure; D011830:Radiation Effects; D013026:Space Flight; D014481:United States
D010100:Oxygen