Relationship between oxygen tension, coronary vasodilation and prostaglandin biosynthesis in the isolated rabbit heart.
In isolated perfused rabbit hearts, coronary vasodilation, produced by reduced oxygen tension seems to be independent of myocardial prostaglandin biosynthesis. a) Anoxia (N2: CO2 95: 5 %) produced coronary vasodilation without causing prostaglandin-like substance (PLS) biosynthesis and release; b) the decrease in coronary resistance during hypoxia (N2:02:CO2 - 80:15:5 %) was sustained during myocardial perfusion with the low oxygen media despite the transitory nature of its PLS release; and c) indomathacin, which abolished basal or ADP stimulated myocardial PLS release, did not abolish the coronary vasodilation produced by ischemia, hypoxia, or anoxia.
D000818:Animals; D003326:Coronary Circulation; D003331:Coronary Vessels / Q000187:drug effects; D000860:Hypoxia; D007213:Indomethacin / Q000494:pharmacology; D007511:Ischemia; D008297:Male; D009206:Myocardium / Q000378:metabolism*; D010100:Oxygen; D010313:Partial Pressure; D011453:Prostaglandins / Q000096:biosynthesis*; D011817:Rabbits; D014655:Vascular Resistance
D011453:Prostaglandins; D010100:Oxygen; D007213:Indomethacin