Beneficial effect of increased dietary linoleate upon in vivo platelet function in man.
The effect of increasing dietary linoleate upon in vivo platelet aggregation and disaggregation in 20 males and 46 female adult humans was studied. In creasing exogenous linoleate for 2 weeks from 2.89 +/- 0.11 to 5.00 +/- 0.26% of energy was associated with the doubling of the aggregation time and halving of the disaggregation time. Decreasing dietary linoleate in the following 2-week feeding period was associated with a reversal of the effect.
D000368:Aged; D001792:Blood Platelets / Q000502:physiology*; D002079:Butter; D004041:Dietary Fats / Q000008:administration & dosage*; D005224:Fats, Unsaturated / Q000494:pharmacology; D005260:Female; D006801:Humans; D008041:Linoleic Acids / Q000494:pharmacology*; D008297:Male; D008383:Margarine; D008875:Middle Aged; D010974:Platelet Aggregation / Q000187:drug effects; D013329:Structure-Activity Relationship; D013997:Time Factors
D004041:Dietary Fats; D005224:Fats, Unsaturated; D008041:Linoleic Acids; D002079:Butter; D008383:Margarine