[Granulocyte stem cells in a case of Chediak-Higashi-Steinbrinck syndrome].
Bone marrow from a child with Chediak-Higashi-Steinbrinck disease was cultured. It was found that all cells with granulocytic colony forming ability were affected by the disease. Cytoplasmic vacuoles were identified as lysosomes by their cytochemical staining. The cloning rates suggest that granulopoiesis is largely ineffective.
D000135:Acid Phosphatase / Q000097:blood; D000469:Alkaline Phosphatase / Q000097:blood; D001853:Bone Marrow / Q000473:pathology*; D001854:Bone Marrow Cells; D002467:Cell Nucleus / Q000473:pathology; D002478:Cells, Cultured; D002609:Chediak-Higashi Syndrome / Q000097:blood / Q000473:pathology*; D002675:Child, Preschool; D002999:Clone Cells; D003593:Cytoplasm / Q000473:pathology; D004950:Esterases / Q000097:blood; D006098:Granulocytes / Q000201:enzymology / Q000473:pathology*; D006801:Humans; D007962:Leukocytes / Q000473:pathology*; D010544:Peroxidases / Q000097:blood; D014617:Vacuoles
D010544:Peroxidases; D004950:Esterases; D000469:Alkaline Phosphatase; D000135:Acid Phosphatase
Etude des cellules souches granulocytaires dans un cas de syndrome de Chediak-Higashi-Steinbrinck