Molecular forms of gastrin in antral mucosa and serum of dogs.
Instillation of liver extract into antral pouches produced an increase in the serum concentrations of both little (G-17) and big (G-34) gastrins. The molar fraction of G-17 plus G-34 represented by G-17 was about 0.9 in antral mucosa and about 0.3 in serum 3 hr after initiating release with liver extract. The predominance of G-34 in serum can be accounted for only in part by its slower rate of removal from the blood so other factors probably also contribute. Although G-17 contributed only about 30% of the total molar concentration of gastrins in serum, it accounted for about 70% of the acid stimulatory activity because on a molar basis it is about five times more bioactive than G-34.
D000818:Animals; D000906:Antibodies; D001706:Biopsy; D002850:Chromatography, Gel; D003714:Denervation; D004285:Dogs; D005215:Fasting; D005747:Gastric Fistula; D005753:Gastric Mucosa / Q000032:analysis*; D005755:Gastrins / Q000032:analysis* / Q000097:blood; D008110:Liver Extracts / Q000494:pharmacology; D008968:Molecular Conformation; D013270:Stomach / Q000033:anatomy & histology / Q000294:innervation; D013997:Time Factors
D000906:Antibodies; D005755:Gastrins; D008110:Liver Extracts