Biotransformation of phenprocoumon in the rat.
The metabolic fate of phenprocoumon [3-(alpha-ethylbenzyl)-4-hydroxycoumarin] in the rat is described. The major metabolites, 4',-6-,7-, and 8-hyproxyphenprocoumon, have been identified yb mass spectrometry, TLC, and uv and compared with authentic smaples. Metabolites are mainly excreted via the feces. The results are compared with those previously reported for warfarin.
D000818:Animals; D001646:Bile / Q000378:metabolism; D001711:Biotransformation; D002855:Chromatography, Thin Layer; D003374:Coumarins / Q000378:metabolism*; D005243:Feces / Q000032:analysis; D013058:Mass Spectrometry; D008862:Microsomes, Liver / Q000378:metabolism; D010644:Phenprocoumon / Q000378:metabolism*; D051381:Rats; D013997:Time Factors; D014859:Warfarin / Q000378:metabolism
D003374:Coumarins; D014859:Warfarin; D010644:Phenprocoumon