Spontaneous adenocarcinomas of the ventral prostate of aged A X C rats.
Spontaneous adenocarcinomas of the ventral prostate were present in 7 of 41 aged (34- to 37-month-old), virgin, untreated male A X C rats. The only consistent gross evidence of possible neoplastic involvement was intraprostate hemorrhage. The principally intraglandular neoplasms were composed of markedly anaplastic epithelial cells which retained a moderate propensity to form glandular patterns. The nuclei of the neoplastic cells were pleomorphic, vesiculated, enlarged, and hyperchromatic. Mitotic figures were frequent. Interglandular connective tissue was invaded in one rat; however, metastases were not demonstrated.
D000230:Adenocarcinoma / Q000473:pathology / Q000662:veterinary*; D000375:Aging; D000818:Animals; D006965:Hyperplasia / Q000473:pathology; D008297:Male; D008938:Mitosis; D010858:Pigmentation; D011471:Prostatic Neoplasms / Q000473:pathology / Q000662:veterinary*; D051381:Rats; D011919:Rats, Inbred Strains; D012376:Rodent Diseases / Q000473:pathology*