Serum prolactin levels of rats under continuous estrogen stimulation and 2 Br-alpha-ergocryptine (CB-154) injection.
The ability of 2 Br-alpha-ergocryptine (CB-154) to suppress serum prolactin levels was examined in animals under the influence of continuous estrogen stimulation. A single injection of polyestradiol phosphate (Estradurin) once every 21 days produced a constant elevation of serum prolactin. The simultaneous administration of 1 mg/day of CB-154 to estrogenized animals suppressed serum prolactin levels below that of Estradurin alone but the levels were significantly greater than those of animals receiving CB-154 alone. It was suggested that, while CB-154 prevents the release of prolactin, estrogen stimulates prolactin synthesis despite the block of its release. Ether anesthesia may be capable of partially overriding  the block of CB-154 and released the stored hormone from the gland.
D000818:Animals; D001835:Body Weight; D001971:Bromocriptine / Q000494:pharmacology*; D002369:Castration; D003864:Depression, Chemical; D004873:Ergolines / Q000494:pharmacology*; D004958:Estradiol / Q000031:analogs & derivatives* / Q000494:pharmacology; D005260:Female; D007279:Injections, Subcutaneous; D009929:Organ Size; D009943:Organophosphorus Compounds / Q000494:pharmacology; D010053:Ovary / Q000502:physiology; D011108:Polymers / Q000494:pharmacology; D011388:Prolactin / Q000097:blood* / Q000378:metabolism; D051381:Rats; D013268:Stimulation, Chemical; D013644:Tartrates / Q000008:administration & dosage; D013997:Time Factors; D014626:Vaginal Smears
D004873:Ergolines; D009943:Organophosphorus Compounds; D011108:Polymers; D013644:Tartrates; D001971:Bromocriptine; D004958:Estradiol; D011388:Prolactin; C008958:polyestradiol phosphate