Is phlorizin or its aglycon the inhibitor of intestinal glucose transport? A study in normal and lactase deficient man.
Inhibition of glucose transport by phlorizin was examined in man by perfusion of an isolated small bowel segment. Inhibition was similar in normal and lactase deficient subjects. Since the small bowel of lactase deficient subjects contains only very small amounts of phlorizin hydrolase, phlorizin and not a product of enzymatic cleavage is the inhibitor of the small intestinal glucose carrier.
D005260:Female; D005947:Glucose / Q000378:metabolism*; D006026:Glycoside Hydrolases / Q000378:metabolism; D006801:Humans; D007408:Intestinal Absorption / Q000187:drug effects*; D007787:Lactose Intolerance / Q000378:metabolism*; D008297:Male; D010693:Phloretin / Q000494:pharmacology*; D010695:Phlorhizin / Q000494:pharmacology*
D010695:Phlorhizin; D006026:Glycoside Hydrolases; D005947:Glucose; D010693:Phloretin