Pharacological prolongation of ischemic tolerance of rat-kidneys by Na-Cu-chlorophyllin.
This experimental study demonstrated that the warm ischemic tolerance of a rat kidney is about 60 mins, in this model. If the warm ischemic time is 60 mins or longer, in unilateral nephrectomized rats, the animals die of renal insufficiency. After pre-operative treatment with Na-Cu-chlorophyllin we observed a significantly lower increase of serum urea and creatinine levels, caused by a pharmacological effect on the kidneys. The prolongation of warm ischemic tolerance of rat kidneys is about 30 mins in this model; that means 50% more than the normal ischemic tolerance. From our results and from the literature we conclude that Na-Cu-chlorophyllin has a membrane stablilizing and an inhibiting effect on autolytic enzymes. The drug Na-Cu-chlorophyllin has indeed 2 positive effects: the immunosuppressive and organ preseving effect. These effects may play a role in donor and recipient pretreatment and treatment after grafting.
D000818:Animals; D001806:Blood Urea Nitrogen; D002734:Chlorophyll / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000494:pharmacology; D003300:Copper / Q000008:administration & dosage / Q000494:pharmacology*; D003404:Creatinine / Q000097:blood / Q000652:urine; D007274:Injections, Intraperitoneal; D007511:Ischemia / Q000378:metabolism / Q000401:mortality; D007668:Kidney / Q000098:blood supply / Q000187:drug effects / Q000378:metabolism*; D051381:Rats; D012964:Sodium / Q000008:administration & dosage / Q000494:pharmacology*; D014508:Urea / Q000097:blood / Q000652:urine
D002734:Chlorophyll; D003300:Copper; D014508:Urea; D012964:Sodium; D003404:Creatinine