[Effect of anisole, anethole, butylhydroxyanisole and safrole on intestinal absorption in the rat (author's transl)].
Using an in situ method of perfusion for rat intestine, we have studied the effect of anisole, anethole, butylhydroxyanisole (BHA) and safrole on the absorption of three metabolites: glucose, butyric acid and  methionine. At a concentration of 2 mg/ml of perfusion medium, safrole, and particularly BHA, reduce the absorption of glucose and methionine but have no effect on that of butyric acid. These results could be explained by variations in intestinal water absorption induced by methoxybenzene compounds, or by changes in the digestive mucosa seen in histological studies.
D000475:Alkenes / Q000494:pharmacology; D000081248:Allylbenzene Derivatives; D000818:Animals; D000840:Anisoles / Q000494:pharmacology*; D002087:Butyrates / Q000378:metabolism; D004149:Dioxoles / Q000494:pharmacology*; D005947:Glucose / Q000378:metabolism; D007408:Intestinal Absorption / Q000187:drug effects; D007422:Intestines / Q000033:anatomy & histology; D008297:Male; D008715:Methionine / Q000378:metabolism; D010477:Perfusion; D051381:Rats; D012451:Safrole / Q000494:pharmacology*; D013997:Time Factors
D000475:Alkenes; D000081248:Allylbenzene Derivatives; D000840:Anisoles; D002087:Butyrates; D004149:Dioxoles; D008715:Methionine; D005947:Glucose; C006578:anethole; D012451:Safrole
Effet de l'anisole, de l'anethole, du butylhydroxyanisole et du safrole sur l'absorption intestinale chez le rat