Combination chemotherapy of Hodgkin disease in children.
MOPP chemotherapy program was employed in 20 children with advanced Hodgkin disease (stages III and IV). Complete remissions were achieved in 13 patients (65%)within an average duration rate of 17.1 months varying from 2 to 40 months. If thses only one patient developed recurrency and died 10 months after the onset of treatment. The remaining 12 children are alive and well; an average survival rate since the onset of MOPP chemotherapy being 20 months. The patients with partial remission died from further progression of the disease within the period from 2 to 15 months. The study showed that histological type and mode of previous treatment had an influence on the results of chemotherapy used. The complications of MOPP chemotherapy were insignificant and easily controlled.
D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D004359:Drug Therapy, Combination; D005260:Female; D006689:Hodgkin Disease / Q000188:drug therapy* / Q000401:mortality; D006801:Humans; D008297:Male; D009588:Nitrogen Mustard Compounds / Q000008:administration & dosage* / Q000627:therapeutic use; D011241:Prednisone / Q000008:administration & dosage* / Q000627:therapeutic use; D011344:Procarbazine / Q000008:administration & dosage* / Q000627:therapeutic use; D012008:Recurrence; D012075:Remission, Spontaneous; D014750:Vincristine / Q000008:administration & dosage* / Q000627:therapeutic use
D009588:Nitrogen Mustard Compounds; D011344:Procarbazine; D014750:Vincristine; D011241:Prednisone