Osteosclerosis in primary hyperparathyroidism.
Osteosclerosis in adults with primary hyperparathyoidism is rare; the usual skeletal manifestation, when presented, is diffuse osteropenia. We describe a patient with generalized osteosclerosis in association with primary hyperparathyroidism. The findings are documented by conventional and fine-detail radiography, absorptiometric bone mineral analysis, quantitative microradiography and histologic examination of bone. The unique features are contrasted with the manifestations recorded in a recently studied group of 87 hyperparathyroid patients. The data presented here support a causal relationship in this patient between parathyroid hormone excess and the development of densely sclerotic bones.
D000236:Adenoma / Q000150:complications / Q000000981:diagnostic imaging; D000328:Adult; D000367:Age Factors; D000368:Aged; D001842:Bone and Bones / Q000000981:diagnostic imaging; D005260:Female; D006801:Humans; D006961:Hyperparathyroidism / Q000150:complications* / Q000000981:diagnostic imaging; D008875:Middle Aged; D010026:Osteosclerosis / Q000150:complications* / Q000000981:diagnostic imaging; D010282:Parathyroid Neoplasms / Q000150:complications / Q000000981:diagnostic imaging; D011859:Radiography