Effects of prostaglandins E-1 and F-2ALPHA on serum luteinizing hormone concentration and on some sexual functions in male rabbits.
PGE-1(50 mu-g/animal) and PGF-2ALPHA (250 mu-g/animal) caused a transient increase in serum LH at 5 min after injection. PGE-1(250 mu-g/animal) had a biphasic effect on serum LH. A small peak was obtained at 5 min, and a second, larger peak at 60 min after injection. It is suggested that the first peak is a result of the stress associated with injection of the PGs, whereas the second peak represents a physiological effect of PGE. Subcutaneous injection of PGE-1(1 mg in arachis oil b.i.d.) for 10 days did not effect the concentration of LH in serum, the function of the accessory sexual glands or the sexual activity. PGF-2ALPHA, given at the same dose and in the same manner, increased the sexual activity but left all other variables unaffected. The pituitary responsiveness to LH-RH was unaltered by the treatment with PGE-1 and PGF-2ALPHA.
D000818:Animals; D003864:Depression, Chemical; D005632:Fructose / Q000032:analysis; D007986:Luteinizing Hormone / Q000097:blood*; D008297:Male; D011458:Prostaglandins E / Q000494:pharmacology*; D011460:Prostaglandins F / Q000494:pharmacology*; D011817:Rabbits; D012661:Semen / Q000187:drug effects / Q000201:enzymology; D012726:Sexual Behavior, Animal / Q000187:drug effects*; D013268:Stimulation, Chemical; D013997:Time Factors
D011458:Prostaglandins E; D011460:Prostaglandins F; D005632:Fructose; D007986:Luteinizing Hormone