Venezuelan equine encephalomyelitis viral infection of newly hatched chickens and embryonating eggs.
Fewer than 25% of 12-hour-old chicks died after subcutaneous inoculation of 5 strains or intracranial inoculation of 3 strains of Venezuelan equine encephalomyelitis virus. Mortality of embryonating chicken eggs inoculated by the allantoic route decreased from approximately 75% to 35% between 9 and 18 days of incubation, although all 18-day-old embryos died after intraembryonic inoculation. Thus, neither newly hatched chicks nor chicken embryos (unless inoculated intraembryonically) would be of value in safety testing inactivated Venezuelan equine encephalomyelitis viral vaccines.
D000818:Animals; D001769:Blood / Q000382:microbiology; D001921:Brain; D002642:Chick Embryo; D002645:Chickens; D004666:Encephalitis Virus, Venezuelan Equine / Q000254:growth & development / Q000276:immunology / Q000472:pathogenicity*; D004683:Encephalomyelitis, Equine / Q000276:immunology / Q000382:microbiology / Q000662:veterinary*; D006385:Hemagglutination Inhibition Tests; D007267:Injections; D007279:Injections, Subcutaneous; D011201:Poultry Diseases / Q000209:etiology* / Q000276:immunology / Q000382:microbiology; D010948:Viral Plaque Assay; D014765:Viral Vaccines
D014765:Viral Vaccines