The analysis of the hypotensive action of new piperazine derivatives in the experimental hypertension in rats.
The correlation of hypotensive action and chemical structure of some new piperazine derivatives was studied in normotensive rats and those with experimental hypertension. In the latter, all the tested derivatives, administered both once and repeatedly, appeared to have hypotensive action of various degree. In normotensive animals, there was no evidence of such action.
D000818:Animals; D000959:Antihypertensive Agents; D001794:Blood Pressure / Q000187:drug effects; D001795:Blood Pressure Determination / Q000379:methods; D003900:Desoxycorticosterone / Q000494:pharmacology; D006973:Hypertension / Q000188:drug therapy*; D008297:Male; D009392:Nephrectomy; D010646:Phentolamine / Q000494:pharmacology; D010879:Piperazines / Q000494:pharmacology / Q000627:therapeutic use*; D051381:Rats; D013329:Structure-Activity Relationship
D000959:Antihypertensive Agents; D010879:Piperazines; D003900:Desoxycorticosterone; D010646:Phentolamine