Automated chromatographic determination of chlorhexidine in pharmaceutical preparations.
An automated method for the determination of chlorhexidine (Hibitane) and its salts in formulated pharmaceutical products is described. The equipment consists of a high efficiency liquid chromatograph, a variable wavelength high sensitivity ultraviolet spectrophotometric detector, the output of which is monitored simultaneously by a suitable recorder, and a digital computer. The sample is automatically introduced onto a 10-cm silica gel column by use of a slide valve. Results are calculated and printed out by the computer.
D001645:Biguanides / Q000032:analysis*; D002710:Chlorhexidine / Q000032:analysis*; D002845:Chromatography / Q000295:instrumentation / Q000379:methods*; D003124:Colorimetry / Q000379:methods; D003201:Computers; D006874:Hydrostatic Pressure; D004364:Pharmaceutical Preparations / Q000032:analysis*; D013056:Spectrophotometry, Ultraviolet
D001645:Biguanides; D004364:Pharmaceutical Preparations; D002710:Chlorhexidine