In vitro incorporation of tritiated thymidine by the Sternberg-Reed cells in Hodgkin disease.
The study of the possibilities of new DNA synthesis by the Sternberg-Reed cells of Hodgkin disease was done with tritated thymidine and autoradiography. The results showed that after incubation pulses of 30 and 60 minutes cells with lobulated nucleus, binucleated and trinucleated cells, identifiable to the diagnostic Sternberg-Reed cells, had possibilities of new DNA synthesis. This points to a more dynamic interpretation of this cell that was considered without chances of cnromosome replication.
D004273:DNA, Neoplasm / Q000096:biosynthesis; D006644:Histiocytes / Q000378:metabolism* / Q000473:pathology; D006689:Hodgkin Disease / Q000378:metabolism* / Q000473:pathology; D006801:Humans
D004273:DNA, Neoplasm