Effects of nitrogen dioxide and 3-methylcholanthrene on pulmonary enzymes.
Guinea pig lung phenol-O-methyltransferase, catechol-O-methyltransferase, and benzpyrene hydroxylase activities were examined after nitrogen dioxide and 3-methylcholanthrene treatment. While benzypyrene hydroxylase activity was enhanced by 3-methylcholanthrene, none of the pulmonary enzyme activities was altered after exposure to either 40 or 70 ppm of nitrogen dioxide for 2 hr.
D001579:Benzopyrene Hydroxylase / Q000378:metabolism; D002394:Catechol O-Methyltransferase / Q000378:metabolism; D008168:Lung / Q000187:drug effects / Q000201:enzymology* / Q000648:ultrastructure; D008748:Methylcholanthrene / Q000494:pharmacology*; D008780:Methyltransferases / Q000378:metabolism; D008861:Microsomes / Q000201:enzymology; D009585:Nitrogen Dioxide / Q000494:pharmacology*; D010636:Phenols
D010636:Phenols; D008748:Methylcholanthrene; D001579:Benzopyrene Hydroxylase; D008780:Methyltransferases; D002394:Catechol O-Methyltransferase; D009585:Nitrogen Dioxide