The excretion of prostaglandin F-2ALPHA in milk of cows.
Prostaglandin F-2ALPHA (PGF-2ALPHA) was measured by immunoassay in plasma and milk of four cows (six experiments). After 30 mg PGF-2ALPHA im, plasma PGF-2ALPHA peaked at 15 minutes (2.4 plus or minus 0.7 ng/ml) and declined toward basal values by 3 hours; maxiumum milk PGF-2ALPHA (0.91 plus or minus 0.12 ng/ml) occurred at 1 hour. The average excretion rate in milk was 2.9 mu-g/day 0.9 mu-g (0.003%) of which was due to the 30 mg PGF-2ALPHA injected. In six nonpregnant control cows, daily changes of milk PGF-2ALPHA and progesterone were not consistently related.
D000818:Animals; D002417:Cattle; D004971:Estrus / Q000187:drug effects; D005260:Female; D008892:Milk / Q000378:metabolism*; D011247:Pregnancy; D011374:Progesterone / Q000378:metabolism; D011460:Prostaglandins F / Q000097:blood / Q000378:metabolism* / Q000494:pharmacology; D013268:Stimulation, Chemical; D013997:Time Factors
D011460:Prostaglandins F; D011374:Progesterone