Comparative effects of kanamycin and amikacin on aortic blood pressure, cardiac rate and surface electrocardiogram in the conscious dog.
Intravenous infusion in conscious beagle dogs of either kanamycin or amikacin to doses of 30 mg/kg resulted in little or no detectible dose related effects on mean aortic blood pressure, cardiac rate, the surface electrocardiogram or gross behavior. Increasing doses of kanamycin and amikacin resulted in dose-related increases in the plasma levels of the two antibiotics. These results indicate that in the conscious dog high plasma levels of kanamycin (64 mug/ml) and amikacin (78 mug/ml) were not associated with depression of systemic blood pressure.
D000583:Amikacin / Q000097:blood / Q000494:pharmacology*; D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects; D001794:Blood Pressure / Q000187:drug effects*; D004285:Dogs; D004562:Electrocardiography; D006339:Heart Rate / Q000187:drug effects*; D007612:Kanamycin / Q000031:analogs & derivatives* / Q000097:blood / Q000494:pharmacology*
D007612:Kanamycin; D000583:Amikacin