Interactions of carbenicillin and ticarcillin with gentamicin.
The in vitro inactivation of gentamicin by carbenicillin and a new semisynthetic penicillin, ticarcillin (BRL 2288), has been demonstrated. Gentamicin half-lives have been studied in eight patients with end-stage renal failure, and a 25 to 74% reduction in half-life has resulted from the concomitant administration of therapeutic doses of carbenicillin and ticarcillin.
D002228:Carbenicillin / Q000494:pharmacology*; D003956:Dialysis; D004347:Drug Interactions; D005839:Gentamicins / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D006207:Half-Life; D006801:Humans; D010406:Penicillins / Q000494:pharmacology*; D013982:Ticarcillin / Q000494:pharmacology*
D005839:Gentamicins; D010406:Penicillins; D013982:Ticarcillin; D002228:Carbenicillin