Increased immunogenicity of two lymphoma lines after drug treatment of athymic (nude) mice.
Highly immunogenic sublines of L1210 and LSTRA lymphomas were obtained from athymic (nude) mice treated with 4(5)-(3,3-dimethyl-1-triazeno)imidazole-5(4)carboxamide (DIC) in vivo. Conventional mice, compatible with the parent tumor, rejected the DIC-treated sublines and were relatively resistant to a subsequent challenge with the parent lines. The DIC-treated sublines were not rejected by athymic mice, which indicated that the transplantation resistance to these tumors in conventional mice was thymus-cell dependent. In addition, there was marginal or no increase of tumor-cell immunogenicity when the parent lines were passaged in nude mice without DIC treatment. This indicated that the DIC-dependent immunogenic changes in DIC-treated leukemic conventional mice could not be ascribed merely to protection by naturally occurring antigenic clones that resulted from DIC-induced immunodepression.
D000818:Animals; D000912:Antibodies, Neoplasm / Q000096:biosynthesis*; D002460:Cell Line; D003606:Dacarbazine / Q000494:pharmacology*; D007167:Immunotherapy; D007939:Leukemia L1210 / Q000276:immunology*; D008223:Lymphoma / Q000276:immunology*; D051379:Mice; D008807:Mice, Inbred BALB C; D008819:Mice, Nude / Q000276:immunology*; D013268:Stimulation, Chemical; D014226:Triazenes / Q000494:pharmacology*
D000912:Antibodies, Neoplasm; D014226:Triazenes; D003606:Dacarbazine