Correlations between physical and drug release characteristics of polyethylene glycol suppositories.
The mechanical strength and elastic moduli of blocks of polyethylene glycol with a range of molecular weights were determined. A rotating-basket dissolution test was used to measure the release characteristics of prednisolone from similar blocks. The effects of blending bases of different molecular weight and of the addition of water also were determined. Linear relationships were found for the mechanical strength, molecular weight, and release rate, but no simple relationship could be observed for the elastic moduli.
D004548:Elasticity; D006244:Hardness; D008970:Molecular Weight; D011092:Polyethylene Glycols; D011241:Prednisone / Q000008:administration & dosage; D013488:Suppositories; D013696:Temperature; D013997:Time Factors; D014867:Water
D013488:Suppositories; D014867:Water; D011092:Polyethylene Glycols; D011241:Prednisone