N-Substituted indanamines as potential hypoglycemic agents.
A number of indanamines substituted at the terminal amino nitrogen with various aliphatic, alicyclic, heterocyclic, and aromatic ring systems were synthesized and screened for hypoglycemic activity. None was found to possess significant activity compared to tolbutamide.
D000588:Amines / Q000494:pharmacology; D000818:Animals; D001786:Blood Glucose / Q000032:analysis; D007004:Hypoglycemic Agents / Q000138:chemical synthesis / Q000494:pharmacology*; D007189:Indans / Q000138:chemical synthesis / Q000494:pharmacology*; D007192:Indenes / Q000494:pharmacology*; D008297:Male; D011817:Rabbits; D014044:Tolbutamide / Q000494:pharmacology
D000588:Amines; D001786:Blood Glucose; D007004:Hypoglycemic Agents; D007189:Indans; D007192:Indenes; D014044:Tolbutamide