Effect of ethynyl estradiol on the secretion of hepatic triglyceride.
The concentrations of triglyceride in the blood of female rats increased 2- and 4-fold during treatment with 5 and 15 mug/kg of ethynyl estradiol, respectively. The rate of secretion of triglyceride increased 66% over controls with livers obtained from the rats administered ethynyl estradiol. Ethynyl estradiol induced a hypocholesterolemia in the donor animals but the secretion of cholesterol into the perfusate from livers obtained from these animal was not affected. Adrenal corticosterone levels were depressed 48% in animals receivint of ethynyl estradiol on the liver or secondary to other hormonal changes.
D000311:Adrenal Glands / Q000378:metabolism; D000818:Animals; D001835:Body Weight; D002784:Cholesterol / Q000097:blood; D003124:Colorimetry; D003345:Corticosterone / Q000378:metabolism; D004997:Ethinyl Estradiol / Q000008:administration & dosage / Q000494:pharmacology*; D005260:Female; D005947:Glucose / Q000378:metabolism; D008099:Liver / Q000187:drug effects / Q000378:metabolism*; D009929:Organ Size; D010477:Perfusion; D051381:Rats; D014280:Triglycerides / Q000097:blood / Q000378:metabolism*
D014280:Triglycerides; D004997:Ethinyl Estradiol; D002784:Cholesterol; D005947:Glucose; D003345:Corticosterone