Gentamicin pharmacokinetics in rats with reduced renal parenchyma.
Pharmacokinetics of intramuscular gentamicin was observed in healty rats, in rats with renal parenchyma reduced to 1/5 of normal and in rats after bilateral nephrectomy. The results obtained support the assumption that in rats gentamicin is excreted only through the kidneys. Reduction of the renal parenchyma to 1/5 of normal is associated with extention of biological half-life only to double the control value. The results support the hypothesis that in the given experimental conditions gentamicin excretion in residual nephrons increases.
D000818:Animals; D001681:Biological Assay; D005839:Gentamicins / Q000097:blood / Q000378:metabolism*; D006207:Half-Life; D007668:Kidney / Q000378:metabolism*; D007700:Kinetics; D008297:Male; D009392:Nephrectomy; D009929:Organ Size; D051381:Rats
D005839:Gentamicins