The possible mode of action of prostaglandins: VIII - cortisone, reserpine and the reversal of the antifertility efficacy of prostaglandin E1 in rats.
A single injection of prostaglandin F1 (PGE1) of 5 mg/kg body weight on Lay 13 of pregnancy caused a consistent luteolysis and resorption of fetuses in rats by Day 20. A concomitant regimen of cortisone, a consistent blocker of nonspecific stresses or reserpine, an adrenergic nerve blocking agent as well as a specific inhibitor of GRF and PIF, concurrently with PGE1 consistently effective in preventing the deleterious efficacy of PGE1 and maintained the growth of the fetuses, placentae, ovaries and corpora lutea as healthy as recorded in the controls. On the basis of experimental documentation it is believed that the PGE1-caused fetal demise is possibly due to a break up of an appropriate hormonal synchronization rather than an over stimulation of uterine smooth musculature.
D000818:Animals; D003338:Corpus Luteum / Q000187:drug effects; D003348:Cortisone / Q000494:pharmacology*; D003864:Depression, Chemical; D005260:Female; D005298:Fertility / Q000187:drug effects*; D005313:Fetal Death; D009929:Organ Size; D010053:Ovary / Q000187:drug effects; D010920:Placenta / Q000187:drug effects; D011247:Pregnancy; D011388:Prolactin / Q000494:pharmacology; D011453:Prostaglandins / Q000494:pharmacology*; D051381:Rats; D012110:Reserpine / Q000494:pharmacology*; D013268:Stimulation, Chemical
D011453:Prostaglandins; D012110:Reserpine; D011388:Prolactin; D003348:Cortisone