Effects of phentolamine on coronary blood flow in patients with recent myocardial infarction.
The myocardial clearance of rubidium may be obtained by praecordial counting after intravenous injection of Rb-minus 86 Cl. Eight patients with recent myocardial infarction had this determination performed before and after the infusion of 10 mg phentolamine at a rate of 0.3 mg/minute. The average predrug myocardial clearance of Rb was 89.3 plus or minus 29.9 ml/min per 100 g myocardium. After phentolamine, the average myocardial clearance rose to 117.3 plus or minus 33.3 ml/min per 100 g myocardium (P LESS THAN 0.01). An explanation for this findings is presented as well as its possible clinical applications.
D000328:Adult; D000368:Aged; D003326:Coronary Circulation / Q000187:drug effects*; D005260:Female; D006801:Humans; D007263:Infusions, Parenteral; D007275:Injections, Intravenous; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000188:drug therapy*; D009206:Myocardium / Q000378:metabolism; D010646:Phentolamine / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*; D011868:Radioisotopes; D012413:Rubidium / Q000378:metabolism
D011868:Radioisotopes; D012413:Rubidium; D010646:Phentolamine