Double-blind comparison of phlebitis produced by cefazolin versus cephalothin.
In a double-blind study with each patient as his own control, 1 g of cefazolin and 2 g of cephalothin were administered intravenously every 6 h to 20 patients in opposite arms for a period of 48 h each. The degree of phlebitis was significantly more severe with cephalothin than with cefazolin (P < 0.05); however, neither the incidence of phlebitis nor the time of onset of phlebitis was significantly different between the two drugs.
D000328:Adult; D002437:Cefazolin / Q000009:adverse effects* / Q000627:therapeutic use; D002511:Cephalosporins / Q000009:adverse effects*; D002512:Cephalothin / Q000009:adverse effects* / Q000627:therapeutic use; D006801:Humans; D010689:Phlebitis / Q000139:chemically induced*
D002511:Cephalosporins; D002437:Cefazolin; D002512:Cephalothin