Determination of methadone hydrochloride in a maintenance dosage formulation.
A colorimetric method for direct quantitative assay of methadone hydrochloride in liquid oral dosage forms is presented. The procedure involves the formation of a dye complex with bromothymol blue buffer solution. The resultant complex is extracted with benzene and measured spectrophotometrically. Duplicate tests on the formulation showed 99.2% of the labeled amount of methadone.
D000284:Administration, Oral; D001554:Benzene; D003124:Colorimetry / Q000379:methods*; D008691:Methadone / Q000008:administration & dosage / Q000032:analysis*; D012996:Solutions; D013053:Spectrophotometry
D012996:Solutions; D001554:Benzene; D008691:Methadone