Response to hypercapnia under ketamine anaesthesia.
The respiratory response to hypercapnia in dogs anaesthetized with ketamine was increased. This respiratory stimulation was most probably due to a direct effect of the drug on the medullary respiratory neurones. This effect was not modified by preanaesthetic medication pentobarbitone 5 mg/kg or morphine 0.1 mg/kg. Catecholamine response to hypercapnia was essentially the same as that reported by hypercapnic dogs anaesthetized with thiopentone.
D000136:Acid-Base Equilibrium; D000771:Anesthesia, Intravenous; D000818:Animals; D001285:Atropine; D001794:Blood Pressure / Q000187:drug effects; D002245:Carbon Dioxide / Q000097:blood; D002395:Catecholamines / Q000097:blood; D002496:Central Venous Pressure / Q000187:drug effects; D004285:Dogs; D006935:Hypercapnia / Q000503:physiopathology; D007649:Ketamine / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D009020:Morphine; D010100:Oxygen / Q000097:blood; D010424:Pentobarbital; D011229:Preanesthetic Medication; D012119:Respiration / Q000187:drug effects*
D002395:Catecholamines; D002245:Carbon Dioxide; D007649:Ketamine; D009020:Morphine; D001285:Atropine; D010424:Pentobarbital; D010100:Oxygen