Anesthesia for intracranial aneurysms.
At the Medical University of South Carolina during the past five years, 62 patients have had intracranial aneurysm surgery, with an overall mortality of 4.8%. Anesthesia was given by me to 14 of these patients. Preoperatively these patients were placed on bedrest, steroid prophylaxis, and sedative and antihypertensive medication to reduce th possibility of recurrent subarrachnoid hemorrhage. Halothane-nitrous oxide-oxygen endotracheal anesthesia with controlled ventilation was used, with careful monitoring of EKG, direct arterial pressure, arterial blood gases, body temperature, and urinary output. Adjuncts for control of bleeding and intracranial pressure were osmotic diuresis, cerebrospinal fluid drainage, minimal head-up tilt, and controlled hypotension using trimethaphan (Arfonad). There were no operative deaths, although one patient died postoperatively. Three patients had neurologic deficitys. These data indicate that controlled hypotension is a safe technic which, when properly used, can reduce the risk of anesthesia for intracranial aneurysm surgery.
D000293:Adolescent; D000328:Adult; D000758:Anesthesia / Q000401:mortality; D000770:Anesthesia, Endotracheal / Q000379:methods*; D000777:Anesthetics; D002648:Child; D006221:Halothane; D006801:Humans; D007023:Hypotension, Controlled; D002532:Intracranial Aneurysm / Q000401:mortality / Q000601:surgery*; D007427:Intracranial Pressure; D008875:Middle Aged; D008991:Monitoring, Physiologic; D009609:Nitrous Oxide; D011229:Preanesthetic Medication; D013345:Subarachnoid Hemorrhage / Q000517:prevention & control; D014294:Trimethaphan / Q000627:therapeutic use
D000777:Anesthetics; D014294:Trimethaphan; D009609:Nitrous Oxide; D006221:Halothane