Pyruvate kinase isozyme patterns of human neoplastic, fetal and adult tissues.
A method of starch gel electrophoresis is described which enables detection of 6 isozymes of human pyruvate kinase (PK, E.C.2.7.1.40). Comparing the PK-isozyme patterns of 53 diverse human tumors with those of normal adult and fetal organ tissues, it was found that the isozyme PK I is predominant in all malignant tumors as well as in almost all fetal organs.
D000328:Adult; D004592:Electrophoresis, Starch Gel; D005333:Fetus / Q000201:enzymology*; D006801:Humans; D007527:Isoenzymes / Q000032:analysis / Q000378:metabolism*; D007680:Kidney Neoplasms / Q000201:enzymology; D008545:Melanoma / Q000201:enzymology; D009369:Neoplasms / Q000201:enzymology*; D011770:Pyruvate Kinase / Q000032:analysis / Q000378:metabolism*
D007527:Isoenzymes; D011770:Pyruvate Kinase