An improved synthesis of 2- and 4-bromoestradiols.
Bromination of estradiol-17beta by 2,4,4,6-tetrabromocyclohexa-2,5-dienone gives 2- and 4-bromoestradiols in good yields.
D001966:Bromine; D004958:Estradiol / Q000031:analogs & derivatives* / Q000138:chemical synthesis
D004958:Estradiol; D001966:Bromine