Metal ion-mediated specific interactions between nucleic acid bases of polynucleotides and amino acid side chains of polypeptides.
Interactions between copolypeptides containing Glu and Tyr residues and polynucleotides can be mediated through divalent metal ions such as Zn-2+ and Ci-2+. Circular dichroism studies show that the binding of metal ion - polypeptide complexes to poly(A) induces an unstacking of adenine bases. Fluorescence investigations demonstrate that Tyrosine - Adenine interactions result from the formation of ternary complexes polypeptide-Zn-2 plus-polynucleotide.
D002118:Calcium / Q000494:pharmacology; D002942:Circular Dichroism; D003300:Copper / Q000494:pharmacology*; D005971:Glutamates / Q000378:metabolism; D008274:Magnesium / Q000494:pharmacology; D010455:Peptides / Q000378:metabolism*; D011119:Polynucleotides / Q000378:metabolism*; D014443:Tyrosine / Q000378:metabolism; D015032:Zinc / Q000494:pharmacology*
D005971:Glutamates; D010455:Peptides; D011119:Polynucleotides; D014443:Tyrosine; D003300:Copper; D008274:Magnesium; D015032:Zinc; D002118:Calcium