Delta-9 -tetrahydrocannabinol and decreased macrophage migration inhibition activity.
Delta-9-Tetrahydrocannabinol (0.31 mg - 1.25 mg per kg body weight) given to immunized rats by intraperitoneal injection depresses the activity of macrophage migration inhibition factor. The lowest levels of activity in peritoneal exudates were observed 15 hours after the injection of cannabinoid. This decreased activity may be related to the impaired cellular immunity observed in regular users of cannabis.
D000818:Animals; D002464:Cell Migration Inhibition; D013759:Dronabinol / Q000276:immunology; D005122:Exudates and Transudates / Q000166:cytology; D005260:Female; D066298:In Vitro Techniques; D008264:Macrophages / Q000187:drug effects*; D010537:Peritoneum / Q000166:cytology; D051381:Rats; D013997:Time Factors
D013759:Dronabinol