Synthesis of alpha-1-noracetylmethadol. A facile N-demethylation of alpha-1-acetylmethadol.
A facile N-demethylation of the narcotic analgesic, alpha-1-acetylmethadol, was accomplished by allowing it to react with mercuric acetate under reflux in dilute acetic acid. The product, alpha-1-noracetylmethadol, was isolated as the hydrochloride in 50% yield. Methadone, when allowed to react with mercuric acetate under the same conditions, did not undergo N-demethylation and was recovered unchanged.
D000818:Animals; D003640:Dealkylation; D008691:Methadone / Q000031:analogs & derivatives*; D008692:Methadyl Acetate / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000494:pharmacology; D051379:Mice; D010146:Pain; D011930:Reaction Time / Q000187:drug effects
D008692:Methadyl Acetate; D008691:Methadone