Teratologic evaluation of imipramine hydrochloride in bonnet (Macaca radiata) and rhesus monkeys (Macaca mulatta).
Imipramine hydrochloride was administered orally twice daily to 18 bonnet and 3 rhesus monkeys between days 23 and 45 of pregnancy for 1-3 or 18-22 days at 1, 2, and 10 times the recommended human dose. No teratologic changes were observed, although signs of maternal toxicity occurred at the high dose level, and the abortion rate was higher than in controls.
D000019:Abortifacient Agents / Q000494:pharmacology; D000818:Animals; D005260:Female; D005865:Gestational Age; D007099:Imipramine / Q000008:administration & dosage / Q000633:toxicity*; D008253:Macaca mulatta; D008255:Macaca radiata; D011247:Pregnancy; D013723:Teratogens / Q000494:pharmacology*; D013997:Time Factors
D000019:Abortifacient Agents; D013723:Teratogens; D007099:Imipramine