[Disulfiram and digestive motility; effect on absorption of ethanol in the rat].
The influence of disulfiram, ethanol and the association disulfiram-ethanol on gastro-intestinal motility and ethanol absorption was studied in rats. It was observed that disulfiram (25 mg/kg) and ethanol (0,8 g/kg), separately administered, decrease gastric emptying a nd increase propulsion in the small intestine; association of the two treatments results in the addition of the particular effects, except in the first intestinal segment. Disulfiram reduces ethanol absorption; very significant correlations have been noted between gastric emptying and ethanol absorption.
D000818:Animals; D004221:Disulfiram / Q000494:pharmacology*; D000431:Ethanol / Q000378:metabolism*; D005769:Gastrointestinal Motility / Q000187:drug effects*; D007408:Intestinal Absorption / Q000187:drug effects; D008297:Male; D051381:Rats
D000431:Ethanol; D004221:Disulfiram
Disulfirame et motilité digestive: incidence sur l'absorption de l'éthanol