Mechanism of plasmic-mediated resistance to cadmium in Staphylococcus aureus.
The mechanism of plasmid-mediated resistance to cadmium in Staphylococcus aureus was investigated. Protein synthesis in cell-free extracts from resistant or susceptible bacteria was equally susceptible to inhibition by Cd(2+), but spheroplasts from resistant bacteria retained their resistance. Resistant bacteria did not have a decreased affinity for cations in general, nor was active metabolism required for exclusion of Cd(2+). The kinetics of Cd(2+) uptake into susceptible and resistant bacteria suggested that the conformation of membrane proteins in resistant bacteria may be important in the exclusion of Cd(2+).
D002104:Cadmium / Q000494:pharmacology*; D004352:Drug Resistance, Microbial; D005111:Extrachromosomal Inheritance; D013210:Staphylococcus / Q000187:drug effects / Q000502:physiology*
D002104:Cadmium