Effect of tetramethylenedisulphotetramine on the membrane conductance increase produced by gamma-amino-butyric acid at the crab neuromuscular junction.
The effect of tetramethylenedisulphotetramine (TETS) on the increase in membrane conductance produced by gamma-aminobutyric acid (GABA) at the hermit crab neuromuscular junction was investigated. TETS produced a dose-dependent antagonism of GABA, which was characterized by a non-parallel shift of the log dose-conductance curve for GABA with a reduced maximal conductance change.
D000613:Aminobutyrates / Q000494:pharmacology*; D000818:Animals; D033381:Anomura / Q000502:physiology*; D001952:Bridged-Ring Compounds; D004553:Electric Conductivity / Q000187:drug effects*; D018756:GABA Antagonists; D066298:In Vitro Techniques; D009469:Neuromuscular Junction / Q000187:drug effects*; D011073:Polyamines / Q000494:pharmacology*; D013450:Sulfones / Q000494:pharmacology; D013570:Synaptic Membranes / Q000187:drug effects*; D005680:gamma-Aminobutyric Acid / Q000494:pharmacology*
D000613:Aminobutyrates; D001952:Bridged-Ring Compounds; D018756:GABA Antagonists; D011073:Polyamines; D013450:Sulfones; D005680:gamma-Aminobutyric Acid; C010349:tetramethylenedisulfotetramine