[On the abortive and teratogenous action of volatile and gaseous anaesthetis agents (author's transl)].
The abortive and teratogenic effect of inhalational anaesthetics is well established. This cannot be explained by metabolic activation of the halogenated hydrocarbons but could be due to a noxious effect on the mitotoc spindle. The inhibition of mitosis  is correlated with the lipid solubility and the anaesthetic effect. Numerous experiments give evidence that the effect of anaesthetics can be explained by their reversible binding to nonpolar sites of protein by Van der Waals' bonds affecting protein conformation. The tubular protein of mitotic spindle seems to be highly sensitive to this change of conformation. To prevent abortion and miscarriage in female operating room personnel it is essential not only to remove the halogenated compunds from room atmosphere but also all other anaesthetic gases and vapors such as nitrous oxide and diethyl ether.
D000019:Abortifacient Agents / Q000494:pharmacology*; D000395:Air Pollutants, Occupational; D000769:Anesthesia, Inhalation / Q000009:adverse effects; D000777:Anesthetics / Q000009:adverse effects*; D001665:Binding Sites; D002455:Cell Division / Q000187:drug effects; D004781:Environmental Exposure; D005260:Female; D006801:Humans; D008938:Mitosis / Q000187:drug effects; D008968:Molecular Conformation; D009784:Occupational Diseases / Q000139:chemically induced*; D009873:Operating Rooms; D011247:Pregnancy; D011485:Protein Binding; D013723:Teratogens
D000019:Abortifacient Agents; D000395:Air Pollutants, Occupational; D000777:Anesthetics; D013723:Teratogens
Zur abortiven und teratogenen Wirkung flüchtiger und gasförmiger Anaesthetica