Effect of human chorionic gonadotropin on blood free fatty acids, glucose and on the release of free fatty acids from subcutaneous adipose tissue in various groups of newborn and adults.
After administration of human chorionic gonadotropin (HCG; 500 IU/kg intramuscularly), the blood concentration of free fatty acids increases within 30 min in 1-day-old full-term, premature and small-for-data newborns. This effect does not appear in 1-day-old newborns of diabetic mothers with insulin-dependent diabetes, in 7-day-old newborns nor in adults. Glucose concentration rises in all groups of newborns, and no effect is observed in adults. In the in vitro study, HCG increases lipolysis in newborns' adipose tissue. This effect was not observed in adults.
D000273:Adipose Tissue / Q000378:metabolism*; D000293:Adolescent; D000328:Adult; D001724:Birth Weight; D001786:Blood Glucose / Q000378:metabolism*; D006063:Chorionic Gonadotropin / Q000494:pharmacology*; D005230:Fatty Acids, Nonesterified / Q000097:blood* / Q000378:metabolism; D005260:Female; D005865:Gestational Age; D006801:Humans; D007231:Infant, Newborn; D007234:Infant, Premature; D008297:Male; D008431:Maternal-Fetal Exchange; D008875:Middle Aged; D011247:Pregnancy; D011254:Pregnancy in Diabetics / Q000378:metabolism; D013268:Stimulation, Chemical
D001786:Blood Glucose; D006063:Chorionic Gonadotropin; D005230:Fatty Acids, Nonesterified