Carbohydrate-induced lipogenesis in the human placenta of normal and diabetic pregnancies.
Using  in vitro incubation, human placental slices have been shown to synthesize lipid from 14-C fructose, but to a lesser extent than from 14-C glucose. Diabetic placentae did not incorporate more of either sugar into lipid than did placentae from normal pregnancies; nor did insulin in the incubation medium enhance lipogenesis. There was a correlation between the extent of incorporation of 14-C fructose and 14-C glucose into triglyceride, suggesting a linked enzyme system for phosphorylation of the two hexoses.
D002784:Cholesterol / Q000096:biosynthesis; D005260:Female; D005632:Fructose / Q000378:metabolism; D005947:Glucose / Q000378:metabolism; D006801:Humans; D066298:In Vitro Techniques; D007328:Insulin / Q000494:pharmacology; D008055:Lipids / Q000096:biosynthesis*; D010743:Phospholipids / Q000096:biosynthesis; D010920:Placenta / Q000201:enzymology / Q000378:metabolism*; D011247:Pregnancy; D011254:Pregnancy in Diabetics / Q000378:metabolism*; D014280:Triglycerides / Q000096:biosynthesis
D007328:Insulin; D008055:Lipids; D010743:Phospholipids; D014280:Triglycerides; D005632:Fructose; D002784:Cholesterol; D005947:Glucose