Increased survival of mouse ependymoblastoma hosts previously treated with dehistonized tumor chromatin.
Half of the mice treated with dehistonized chromatin (protein-DNA complex) from a transplantable mouse ependymoblastoma before subcutaneous challenge with the syngeneic tumor survived twice as long as untreated animals.
D000818:Animals; D001921:Brain / Q000276:immunology; D002478:Cells, Cultured; D002843:Chromatin / Q000276:immunology / Q000494:pharmacology*; D004806:Ependymoma / Q000139:chemically induced / Q000276:immunology / Q000503:physiopathology*; D006657:Histones / Q000494:pharmacology*; D007114:Immunization; D008748:Methylcholanthrene; D051379:Mice; D008810:Mice, Inbred C57BL; D013997:Time Factors
D002843:Chromatin; D006657:Histones; D008748:Methylcholanthrene