Pharmacokinetic model for a primary antibody response.
Antigen distribution and clearance studied in vivo may be viewed as a pharmacokinetic problem complicated by the intervention of the immune response. A model characterizing the clearance of the simple antigen phiX174 from the bloodstream of various experimental animals, as well as the subsequent serum antibody response, was developed. The present model is the simplest of the possible models and no doubt will have to be modified when considering more complex antigens, additional distribution modes, and differences in antibody reactivity. For the primary (IgM) immune response, however, early events in the immunological response can be adequately accounted for in a consistent and quantitative manner.
D000818:Animals; D000914:Antibodies, Viral / Q000032:analysis; D000917:Antibody Formation; D000956:Antigens, Viral; D003090:Coliphages / Q000276:immunology; D005333:Fetus / Q000276:immunology; D006168:Guinea Pigs / Q000276:immunology; D007700:Kinetics; D051379:Mice; D008815:Mice, Inbred Strains / Q000276:immunology; D008954:Models, Biological; D012756:Sheep / Q000276:immunology
D000914:Antibodies, Viral; D000956:Antigens, Viral