The relationship of IgA and IgE deficiency.
Studies of IgE deficiency and IgE levels in selective IgA deficiency and ataxia-telangiectasia are reviewed. Isolated IgE deficiency and combined IgE-IgA deficiency do not predispose individuals to recurrent respiratory tract disease. In contrast, IgA-deficient patients with normal or elevated levels of IgE frequently have recurrent respiratory infections. Although IgE deficiency and combined IgE-IgA deficiency occur frequently in ataxia-telangiectasia, these deficiences do not appear to play a primary role in the pathogenesis of sinopulmonary disease in these patients. These observations are discussed in relation to recent evidence concerning the regulation of the IgE-antibody response.
D001260:Ataxia Telangiectasia / Q000276:immunology; D017098:IgA Deficiency; D007073:Immunoglobulin E / Q000032:analysis / Q000172:deficiency*; D007153:Immunologic Deficiency Syndromes / Q000150:complications; D008231:Lymphopenia / Q000209:etiology; D011863:Radioimmunoassay; D012140:Respiratory Tract Diseases / Q000209:etiology
D007073:Immunoglobulin E