Absorption of metrizamide from cereb rospinal fluid to blood: pharmacokinetics in humans.
The rate of transfer of contrast agents from cerebrospinal fluid to blood is of clinical importance in radiological examinations of the subarachnoid space. Metrizamide, a potential contrast medium, was injected intrathecally to humans and serum levels at different times after injection were measured. A one-compartment open model was found to apply to the data. Considerable individual variations were found, but the mean absorption rate constant indicated that more than 50% of the absorbed dose had disappeared from the cerebrospinal fluid 0.75 hr after injection. TLC of the fraction excreted in the urine showed that metrizamide was not metabolized in the body.
D000617:Aminoglycosides / Q000378:metabolism*; D006207:Half-Life; D006801:Humans; D007455:Iodine / Q000097:blood; D007700:Kinetics; D008793:Metrizamide / Q000097:blood / Q000134:cerebrospinal fluid / Q000378:metabolism*
D000617:Aminoglycosides; D007455:Iodine; D008793:Metrizamide