Investigation of some materials as dry binders for direct compression in tablet manufacture. Part 1: flow properties and water sorption.
Four substances were evaluated for their potential usefulness as dry binders for direct compression techniques in tablet making. The flow properties of these substances including angle of repose, timed delivery through an orifice and compressibility were determined. The effect of particle size of the binder on its flow properties was investigated. Comparative rates of water sorption demonstrated by the various substances evaluated as dry binders were also determined.
D000042:Absorption; D002626:Chemistry, Pharmaceutical; D003720:Densitometry; D008353:Mannitol; D010316:Particle Size; D014677:Pharmaceutical Vehicles; D011312:Pressure; D013607:Tablets; D013678:Technology, Pharmaceutical; D014867:Water
D014677:Pharmaceutical Vehicles; D013607:Tablets; D014867:Water; D008353:Mannitol