Hypothermic response following administration of 2-amino-4-pentenoic acid (allylglycine).
Intraperitoneal administration of allylglycine resulted in a hypothermic response in rats. At a dosage of 90 mg/kg, a significant decrease in temperature was noted at 4 and 8 hr after administration, but no significant difference was noted at 12 hr. The same dose administered intraperitoneally to decapitated rats did not result in a hypothermic response, and intraventricular administration resulted in a rapid onset of hypothermia after 1 hr. These findings are indicative of a central site of action for the allylglycine-induced hypothermia. Quantitative assay of hypothalamic monoamines (norepinephrine, serotonin, and dopamine) did not show any significant changes at 4, 8, and 12 hr postadministration when compared to controls. A significant decrease in hypothalamic gamma-aminobutyric acid was noted at each of these time points when compared to controls. These data suggest an important role for gamma-aminobutyric acid in mammalian thermoregulatory control.
D000498:Allyl Compounds / Q000494:pharmacology; D000818:Animals; D001831:Body Temperature / Q000187:drug effects*; D001833:Body Temperature Regulation / Q000187:drug effects; D002552:Cerebral Ventricles; D003864:Depression, Chemical; D004298:Dopamine / Q000378:metabolism; D018756:GABA Antagonists; D005998:Glycine / Q000031:analogs & derivatives* / Q000494:pharmacology; D007031:Hypothalamus / Q000378:metabolism; D007267:Injections; D007274:Injections, Intraperitoneal; D008297:Male; D009638:Norepinephrine / Q000378:metabolism; D051381:Rats; D012701:Serotonin / Q000378:metabolism; D013997:Time Factors
D000498:Allyl Compounds; D018756:GABA Antagonists; D012701:Serotonin; D005998:Glycine; D004298:Dopamine; D009638:Norepinephrine