Transient coagulation abnormalities after incompatible blood transfusion.
This report describes an unusual hemolytic transfusion reaction. A group O donor was inadvertently transfused with 100 ml of group A red cells during the course of plasmapheresis. Granulocytopenia, thrombocytopenia, hypofibrinogenemia and low levels of factors V, VIII, and IX developed immediately after the infusion. The levels of the cellular elements and coagulation proteins returned to normal in less than an hour; too rapid for a de novo synthesis after consumption of coagulation proteins. We postulate that activation of the kinin system was responsible for the phenomena rather than intravascular coagulation with secondary fibrinolysis.
D000017:ABO Blood-Group System; D000328:Adult; D001772:Blood Cell Count; D001778:Blood Coagulation Disorders / Q000097:blood / Q000188:drug therapy / Q000209:etiology*; D001779:Blood Coagulation Factors / Q000032:analysis; D001780:Blood Coagulation Tests; D001782:Blood Donors; D001787:Blood Group Incompatibility / Q000209:etiology*; D005340:Fibrinogen / Q000032:analysis; D006400:Hematocrit; D006452:Hemoglobinometry; D006456:Hemoglobinuria; D006801:Humans; D007705:Kinins / Q000378:metabolism; D008297:Male; D008353:Mannitol / Q000627:therapeutic use; D010956:Plasmapheresis / Q000009:adverse effects*; D012882:Skin Tests; D013997:Time Factors; D014554:Urination
D000017:ABO Blood-Group System; D001779:Blood Coagulation Factors; D007705:Kinins; D008353:Mannitol; D005340:Fibrinogen