Reduction of hypoxic pulmonary vasoconstriction during trichloroethylene anesthesia.
A double-lumen tube was inserted into the trachea of dogs anesthetized with intravenous pentobarbital (30-40 mg/kg). Blood flow/unit lung volume in each lung was measured with 133Xe. Both lungs were initially ventilated with oxygen and measurements of pulmonary blood flow, CO2 output, cardiac output, and blood gases were made. When nitrogen was administered to one lung blood flow was diverted to the opposite lung. The diversion of flow was reduced by the inhalation of 1% trichloroethylene but returned after withdrawal of the anesthetic. There were no significant changes in cardiac output. Changes in CO2 output and arterial Po2 were compatible with the xenon results. It is concluded that trichloroethylene may increase arterial hypoxemia by reducing vasoconstriction in hypoxic areas of lung.
D000758:Anesthesia; D000818:Animals; D001794:Blood Pressure; D002245:Carbon Dioxide; D002302:Cardiac Output; D004285:Dogs; D000860:Hypoxia / Q000209:etiology / Q000503:physiopathology*; D008168:Lung / Q000098:blood supply*; D008176:Lung Volume Measurements; D010100:Oxygen; D010313:Partial Pressure; D011652:Pulmonary Circulation; D014241:Trichloroethylene / Q000494:pharmacology*; D014655:Vascular Resistance; D014666:Vasomotor System / Q000187:drug effects / Q000503:physiopathology*; D014692:Ventilation-Perfusion Ratio; D014980:Xenon Radioisotopes
D014980:Xenon Radioisotopes; D002245:Carbon Dioxide; D014241:Trichloroethylene; D010100:Oxygen