1-beta-D-arabinofuranosylcytosine-induced chromatid breakage: effect of inhibition of DNA synthesis.
The frequency of chromatid breakage induced by 1-beta-D-arabinofuranosylcytosine was decreased when hamster cell fibroblasts were treated with chemical agents that interferred with DNA synthesis immediately before addition of the analog. This phenomenon occurred in both the S and G2 phases of the cell cycle.
D000818:Animals; D001562:Benzimidazoles / Q000494:pharmacology; D002455:Cell Division; D002460:Cell Line; D002842:Chromatids / Q000187:drug effects*; D006224:Cricetinae; D003513:Cycloheximide / Q000494:pharmacology; D003561:Cytarabine / Q000494:pharmacology*; D004247:DNA / Q000096:biosynthesis; D004261:DNA Replication / Q000187:drug effects*; D003609:Dactinomycin / Q000494:pharmacology; D003864:Depression, Chemical; D005347:Fibroblasts / Q000378:metabolism / Q000648:ultrastructure; D006918:Hydroxyurea / Q000494:pharmacology; D014176:Protein Biosynthesis; D012313:RNA / Q000096:biosynthesis; D013438:Sulfhydryl Compounds / Q000494:pharmacology
D001562:Benzimidazoles; D013438:Sulfhydryl Compounds; D003561:Cytarabine; D003609:Dactinomycin; D012313:RNA; D004247:DNA; D003513:Cycloheximide; D006918:Hydroxyurea