Influence of body weight on estradiol metabolism in young women.
The metabolism of estradiol in girls with anorexia nervosa was compared with obese subjects and normal weight, age and sex matched controls. Increasing body weight was accompanied by a sharp decrease in 2-hydroxylation of estradiol and an increase in 16alpha-hydroxylation. These metabolic changes are discussed in terms of the biological activity of 2-hydroxyestrone and estriol.
D000293:Adolescent; D000328:Adult; D000856:Anorexia Nervosa / Q000378:metabolism*; D001835:Body Weight; D004958:Estradiol / Q000378:metabolism*; D005260:Female; D006801:Humans; D009765:Obesity / Q000378:metabolism*; D039181:Steroid 16-alpha-Hydroxylase
D004958:Estradiol; D039181:Steroid 16-alpha-Hydroxylase