Anticoagulant potency of mucosal and lung heparin.
Hog mucosal heparin was compared with beef lung heparin in 24 healthy male and female subjects by double-blind crossover study, by both intravenous and subcutaneous routes, to determine their relative anticoagulant effects as estimated by the activated partial thromboplastin test. Both drugs by both routes induced therapeutically comparable anticoagulation effects, without adverse experience. Thus both products are equivalent, unit for unit.
D000818:Animals; D000925:Anticoagulants / Q000008:administration & dosage / Q000494:pharmacology*; D005260:Female; D006493:Heparin / Q000008:administration & dosage / Q000494:pharmacology*; D006801:Humans; D007275:Injections, Intravenous; D007279:Injections, Subcutaneous; D008168:Lung; D008297:Male; D009092:Mucous Membrane; D013552:Swine; D013925:Thromboplastin / Q000032:analysis; D013997:Time Factors
D000925:Anticoagulants; D006493:Heparin; D013925:Thromboplastin