[Change in the RNA content in the rat endometrium under the action of estrogen-megestrol and neurotropic substances].
The effect of the hormone-like estrogen-progestagen preparation megestranol and of megestranol-spasmolytin combination on the activity of metabolic processes in the uterine mucous membrane was studied in experiments on rats. Results of cytochemical studies showed megestranol and megestranol-spasmolytin combination to change  the metabolic activity of the uterine mucous membrane resulting in a decrease in the RNA content in the epithelial cells of the endometrial glands, thereby creating conditions preventing normal implantation and development of the fertilized ovum.
D000818:Animals; D003864:Depression, Chemical; D004305:Dose-Response Relationship, Drug; D004338:Drug Combinations; D004717:Endometrium / Q000032:analysis / Q000187:drug effects*; D004847:Epithelial Cells; D004848:Epithelium / Q000187:drug effects; D005260:Female; D008535:Megestrol / Q000494:pharmacology*; D012313:RNA / Q000032:analysis*; D051381:Rats; D013997:Time Factors
D004338:Drug Combinations; D012313:RNA; D008535:Megestrol
Izmenenie soderzhaniia RNK v éndometrii krys pri deĭstvii éstrogen-megestrolovykh i neĭrotropnykh veshchestv