Inhibition of the sympathetic nervous system by dopamine.
If the right postganglionic cardioaccelerator nerves of cats are stimulated (2 Hz), dopamine, in the presence of cocaine, inhibits transmission. This inhibitory response is prevented by low doses of haloperidol. Phentolamine produces some antagonism and phenoxy-benzamine produces no antagonism to the dopamine-induced inhibition. It is postulated that dopamine receptors on the adrenergic nerve terminals modulate norepinephrine release.
D000818:Animals; D001338:Autonomic Fibers, Postganglionic / Q000502:physiology*; D001794:Blood Pressure / Q000187:drug effects; D002415:Cats; D003042:Cocaine / Q000494:pharmacology; D003864:Depression, Chemical; D004298:Dopamine / Q000494:pharmacology*; D004558:Electric Stimulation; D006220:Haloperidol / Q000494:pharmacology; D006339:Heart Rate / Q000187:drug effects; D009638:Norepinephrine / Q000494:pharmacology; D010643:Phenoxybenzamine / Q000494:pharmacology; D010646:Phentolamine / Q000494:pharmacology; D010656:Phenylephrine / Q000494:pharmacology; D013268:Stimulation, Chemical; D013564:Sympathetic Nervous System / Q000187:drug effects*
D010643:Phenoxybenzamine; D010656:Phenylephrine; D003042:Cocaine; D006220:Haloperidol; D004298:Dopamine; D009638:Norepinephrine; D010646:Phentolamine