The effect of acute ethanol treatment on lipid-reesterifying enzymes of the rat small bowel.
The acute effects of intraduodenal administration of ethanol, 5 g/kg body weight, on intestinal activities of lipid-reesterifying and disaccharidase enzymes of the small bowel were studied. Results were compared to those produced in controls receiving isocaloric amounts of glucose by the same route. Acyl-CoA:monoglyceride acyltransferase, acyl-CoA synthetase (acid:CoA ligase (AMP) EC 6.2.1.3), sucrase, and lactase assays were performed on jejunal samples; acyl-CoA synthetase assay was performed on ileal samples. Ethanol produced greater activities of the lipid-reesterifying enzymes in the jejunum than did glucose. Ileal specific activity of acyl-CoA synthetase was also increased in the experimental group. No effect of ethanol on jejunal disaccharidase enzyme activities was noted. It is concluded that ethanol given acutely has a specific stimulating effect on intestinal enzymes involved in lipid absorption.
D000217:Acyltransferases / Q000378:metabolism*; D000249:Adenosine Monophosphate; D000435:Alcoholic Intoxication / Q000201:enzymology*; D000818:Animals; D003065:Coenzyme A; D003066:Coenzyme A Ligases / Q000378:metabolism*; D000431:Ethanol / Q000494:pharmacology*; D005696:Galactosidases / Q000378:metabolism*; D005947:Glucose / Q000494:pharmacology; D006801:Humans; D007408:Intestinal Absorption / Q000187:drug effects; D007421:Intestine, Small / Q000201:enzymology*; D050356:Lipid Metabolism; D008297:Male; D009829:Oleic Acids; D010169:Palmitic Acids; D051381:Rats; D013393:Sucrase / Q000378:metabolism*
D009829:Oleic Acids; D010169:Palmitic Acids; D000431:Ethanol; D000249:Adenosine Monophosphate; D000217:Acyltransferases; D005696:Galactosidases; D013393:Sucrase; D003066:Coenzyme A Ligases; D005947:Glucose; D003065:Coenzyme A