[Effect of prothixen and related compounds on serotonin absorption by human thrombocytes].
Distribution of preparations in the order of reduction of the inhibitory influence on serotonin (ST) absorption by platelets corresponded to the distribution of the preparations, by decrease in the thymoanaleptic action: chlorimipramine greater than imipramine greater than amitryptiline desimpramine-nortyptyline-chlorprotixen greater than chlorpromaxine greater than norprotixen greater than protixen-propazine. A change in the influence of the preparation on the ST absorption by platelets caused by the administration into the structure of the chlorine atom compound or by demethylation of the preparation was largely determined by the chemical structure of the initial compound.
D000042:Absorption; D000639:Amitriptyline / Q000494:pharmacology; D001692:Biological Transport / Q000187:drug effects; D001792:Blood Platelets / Q000187:drug effects* / Q000378:metabolism; D002463:Cell Membrane Permeability / Q000187:drug effects; D002746:Chlorpromazine / Q000494:pharmacology; D002997:Clomipramine / Q000494:pharmacology; D003864:Depression, Chemical; D003891:Desipramine / Q000494:pharmacology; D006801:Humans; D007099:Imipramine / Q000494:pharmacology; D066298:In Vitro Techniques; D009661:Nortriptyline / Q000494:pharmacology; D012701:Serotonin / Q000378:metabolism*; D013329:Structure-Activity Relationship; D013892:Thioxanthenes / Q000494:pharmacology*; D014227:Triazines / Q000494:pharmacology
D013892:Thioxanthenes; D014227:Triazines; D000639:Amitriptyline; D012701:Serotonin; D009661:Nortriptyline; D002997:Clomipramine; D007099:Imipramine; D003891:Desipramine; D002746:Chlorpromazine
Vliianie protiksena i blizkikh k nemu soedineniĭ na pogloshchenie serotonina trombotsitami krovi cheloveka