Synthesis of the pentadecapeptide sequence of the active site of rabbit muscle triosephosphate isomerase.
The pentadecapeptide fragment, Trp-Val-Leu-Ala-Tyr-Glu-Pro-Val-Trp-Ala-Ile-Gly-Thr-Gly-Lys, which constitutes a part of the active site of rabbit muscle triosephosphate isomerase has been synthesized. It does not exhibit any catalytic activity typical of triosephosphate isomerase.
D000595:Amino Acid Sequence; D000818:Animals; D001665:Binding Sites; D002238:Carbohydrate Epimerases / Q000138:chemical synthesis*; D009132:Muscles / Q000201:enzymology; D010446:Peptide Fragments / Q000138:chemical synthesis* / Q000378:metabolism; D011817:Rabbits; D014305:Triose-Phosphate Isomerase / Q000138:chemical synthesis* / Q000378:metabolism
D010446:Peptide Fragments; D002238:Carbohydrate Epimerases; D014305:Triose-Phosphate Isomerase