HL-A27 and ankylosing spondylitis in B.C. Indians.
HL-A antigens were determined in Haida and Bella Coola native Indians, two communities known to have a high prevalence of ankylosing spondylitis. Tests were conducted on those with x-ray evidence of sacro-iliitis and on a sample of the community at large. Sacro-iliitis was found to prevail in approximately 10 per cent of adult Haida males and in over two per cent of Bella Coola adult males. Of 20 Haidas with sacro-iliitis, 17 were HL-A 27 positive. Fifty per cent of the Haida community at large were HL-A 27 positive. Three Bella Coolas known to have sacro-iliitis were all HL-A 27 positive, while 25 per cent of the community sampled at large were HL-A 27 positive. About one in five adult Haida males who were HL-A 27 positive showed evidence of sacro-iliitis, a proportion close to that ascertained in Caucasian communities. It would appear, therefore that the risk of disease in HL-A 27 positive Bella Coola males is considerably lower.
D000328:Adult; D001955:British Columbia; D005260:Female; D006680:HLA Antigens; D006648:Histocompatibility; D006649:Histocompatibility Antigens; D006720:Homozygote; D006801:Humans; D007198:Indians, North American; D008297:Male; D012446:Sacroiliac Joint / Q000276:immunology; D013167:Spondylitis, Ankylosing / Q000235:genetics / Q000276:immunology* / Q000473:pathology
D006680:HLA Antigens; D006649:Histocompatibility Antigens