Influence of apomorphine on brain serotonin turnover rate.
Apomorphine (5.0 mg/kg) accelerated the disappearance of 5-HIAA from the brain of pargylinepretreated rats as well as depletion of brain 5-HT caused by inhibition of its synthesis. The latter effect has been abolished by spiroperidol. The results obtained suggest that apomorphine increases the 5-HT turnover rate, secondary to the stimulation of central dopamine receptors.
D000577:Amides / Q000494:pharmacology; D000818:Animals; D001058:Apomorphine / Q000494:pharmacology*; D001921:Brain / Q000378:metabolism*; D003864:Depression, Chemical; D006897:Hydroxyindoleacetic Acid / Q000378:metabolism; D008297:Male; D010293:Pargyline / Q000494:pharmacology; D051381:Rats; D012701:Serotonin / Q000378:metabolism*; D013134:Spiperone / Q000494:pharmacology; D013997:Time Factors
D000577:Amides; D012701:Serotonin; D013134:Spiperone; D006897:Hydroxyindoleacetic Acid; D010293:Pargyline; D001058:Apomorphine