Evidence for two active X chromosomes in a human XXY triploid.
A human XXY chromatin negative triploid culture has been found to have both the A and B isozymes of glucose-6-phosphate dehydrogenase, as well as an intermediately migrating AB (hybrid) band. This finding indicates that the cells in this culture each possess 2 active X chromosomes. Possible mechanisms producing the abnormalities seen in this disorder are presented and discussed.
D000022:Abortion, Spontaneous / Q000235:genetics; D002478:Cells, Cultured; D005260:Female; D005954:Glucosephosphate Dehydrogenase / Q000032:analysis; D006801:Humans; D007527:Isoenzymes / Q000032:analysis; D008297:Male; D011123:Polyploidy; D011247:Pregnancy; D012728:Sex Chromatin / Q000032:analysis*; D012729:Sex Chromosome Aberrations / Q000201:enzymology / Q000235:genetics*
D007527:Isoenzymes; D005954:Glucosephosphate Dehydrogenase