Effect of surface roughness and coating solvent on film adhesion to tablets.
The adhesion of a polymer film to selected tablet substrates was studied. The effect of tablet surface roughness and film-coating solvent on the adhesion of the film to the tablet was determined. A film-coating solvent having a solubility parameter close to that of the polymer was found to produce a stronger adhesional bond than a solvent having a lower surface tension. An increase in tablet surface roughness also increased film adhesion to the tablet. The adhesion was measured as the force required to peel a section of film from the tablet with a stress-strain analyzer.
D000045:Acacia; D000268:Adhesiveness; D002482:Cellulose; D002626:Chemistry, Pharmaceutical; D008274:Magnesium; D008277:Magnesium Oxide; D011108:Polymers; D012997:Solvents; D013228:Stearates; D013314:Stress, Mechanical; D013499:Surface Properties; D013500:Surface Tension; D013607:Tablets; D013608:Tablets, Enteric-Coated; D013627:Talc
D011108:Polymers; D012997:Solvents; D013228:Stearates; D013607:Tablets; D013608:Tablets, Enteric-Coated; D013627:Talc; D008277:Magnesium Oxide; D002482:Cellulose; D008274:Magnesium