[Effect of the multiple administration of hydrocortisone on the ultrastructure of the lymph nodes of rabbits].
The effect of dayly multiple exposure to hydrocortison in the dose 1 mg/kg on the submicroscopic structure of the mesenteric lymphatic nodes in rabbits was studied. In contrast to a single-dose administration of the hormone, no pycnotic forms of small and middle lymphocytes were observed. Prolonged application of hydrocortison led to the appearance of atypical forms of reticular cells, an increase in the number of plasmatised lymphocytes, as well as of mature plasmatic cells. Macrophages disappear almost entirely. The number of dark lymphocytes and reticular cells with the thickened matrix of the cytoplasma and great number of ribosomes and polysomes increased considerably. Mechanisms of action of single and multiple doses of hydrocortison on the cells of lymphatic nodes was not identical.
D000818:Animals; D006854:Hydrocortisone / Q000008:administration & dosage / Q000494:pharmacology*; D008198:Lymph Nodes / Q000187:drug effects* / Q000648:ultrastructure; D008214:Lymphocytes / Q000187:drug effects / Q000648:ultrastructure; D008264:Macrophages / Q000187:drug effects / Q000648:ultrastructure; D008297:Male; D010950:Plasma Cells / Q000187:drug effects / Q000648:ultrastructure; D011817:Rabbits; D012156:Reticulocytes / Q000187:drug effects / Q000648:ultrastructure; D013997:Time Factors
D006854:Hydrocortisone
Vliianie mnogokratnogo vvedeniia gidrokortizona na ul'trastrukturu limfaticheskikh uzlov krolikov