Prednisone-induced hemostasis in a platelet function abnormality.
A 6-year old girl had chronic thrombocytopenia and substantial platelet function abnormality associated with detectable IgM antiplatelet antibody. Treatment with prednisone was followed by an improvement in bleeding time, although in vitro platelet function deteriorated. This observation suggests an effect of prednisone on hemostasis that is independent of platelet function. Further trials of prednisone in patients with similar platelet function abnormalities who have a substantial bleeding tendency would appear indicated.
D000244:Adenosine Diphosphate / Q000494:pharmacology; D000818:Animals; D001327:Autoimmune Diseases / Q000175:diagnosis; D001772:Blood Cell Count; D001778:Blood Coagulation Disorders / Q000188:drug therapy*; D001791:Blood Platelet Disorders / Q000188:drug therapy*; D001792:Blood Platelets / Q000503:physiopathology; D002648:Child; D005260:Female; D006041:Goats / Q000276:immunology; D006385:Hemagglutination Inhibition Tests; D006487:Hemostasis; D006801:Humans; D007106:Immune Sera; D007075:Immunoglobulin M / Q000378:metabolism; D010973:Platelet Adhesiveness; D010974:Platelet Aggregation; D010977:Platelet Factor 3 / Q000378:metabolism; D011241:Prednisone / Q000494:pharmacology / Q000627:therapeutic use*; D011697:Purpura, Thrombotic Thrombocytopenic / Q000503:physiopathology
D007106:Immune Sera; D007075:Immunoglobulin M; D010977:Platelet Factor 3; D000244:Adenosine Diphosphate; D011241:Prednisone