Tolerance and cross-tolerance to the effects of amphetamine, methamphetamine and fenfluramine on milk consumption in the rat.
It has been reported that rats develop tolerance to the milk intake suppressant effects of d-amphetamine, d-methamphetamine, and d, l-fenfluramine. However, it has been hypothesized that the mechanism of action of fenfluramine is different from that of the other two drugs. In the present experiment, rats were given one of these 3 phenylethylamine derivatives each day until tolerance developed to the suppression of milk intake. A second of these drug s was then substituted and milk intake measured. There was cross-tolerance to the drug-induced suppression between d-amphetamine and d-methamphetamine, but not between d-amphetamine and d,l-fenfluramine. The lack of cross tolerance suggests a different mechanism of action for these drugs.
D000818:Animals; D003864:Depression, Chemical; D003913:Dextroamphetamine / Q000494:pharmacology*; D004327:Drinking Behavior / Q000187:drug effects*; D004334:Drug Administration Schedule; D004361:Drug Tolerance; D005277:Fenfluramine / Q000494:pharmacology*; D008694:Methamphetamine / Q000494:pharmacology*; D051379:Mice; D008892:Milk; D051381:Rats
D005277:Fenfluramine; D008694:Methamphetamine; D003913:Dextroamphetamine