[Effect of histamine and diprazin on the course of experimental amyloidosis in mice].
In experiment on 33 mice, line C57Bl, the effect of changed vascular-tissue permeability following administration of histamine and anti-histamine preparation diprazin (pipolphen) on the development of amyloidosis was studied. It was shown that histamine stimulated the development of amyloidosis in mice, causing besides generalized vascular disorders and a pronounced mast-cell reaction with degranulation of these cells, whereas diprazin, on the contrary, inhibited amyloidogenesis in mice. Differences between experimental and control groups were identified using the morphometric method and were confirmed statistically. The difference in the degree of amyloidosis revealed against the background of administration of histamine and diprazin testified to a certain extent to the role of impaired vascular-tissue permeability in the pathogenesis of amyloidosis.
D000686:Amyloidosis / Q000188:drug therapy* / Q000473:pathology; D000818:Animals; D001798:Blood Proteins / Q000032:analysis; D003864:Depression, Chemical; D006632:Histamine / Q000494:pharmacology*; D007279:Injections, Subcutaneous; D008198:Lymph Nodes / Q000473:pathology; D051379:Mice; D008810:Mice, Inbred C57BL; D011398:Promethazine / Q000494:pharmacology*; D013154:Spleen / Q000473:pathology; D013268:Stimulation, Chemical; D013997:Time Factors
D001798:Blood Proteins; D006632:Histamine; D011398:Promethazine
Vliianie gistamina i diprazina na techenie éksperimental'nogo amiloidoza u mysheĭ