[Effect of corticosteroids on the enzymatic activity of hepatic tissue].
Tests conducted with rats demonstrated that hydrocortisone and desoxycorticosterone-acetate (DOCA) manifest an effect close by its orientation with regard to mitochondrial and extramitochondrial forms of aspartate- and alanine-aminotransferase (ACT and ALT), as well as cytoplasmatic malate-dehydrogenase (MDG) of the liver. It was only mitochondrial MDG that lent itself to be inhibited by hydrocortisone, but it was induced by DOCA. Adrenalectomy resulted in inhibition on ALT and MDG and in activation of ACT and of mitochondrial LDG. A course-wise introduction of sulphapyridazine with an excess of deficiency of corticosteroids changed the effects of hydrocortisone with respect to cytoplasmatic LDG, as well as the effects of DOCA or adrenalectomy in regard to LDG and MDG.
D000305:Adrenal Cortex Hormones / Q000494:pharmacology*; D000311:Adrenal Glands / Q000502:physiology; D000315:Adrenalectomy; D000410:Alanine Transaminase / Q000378:metabolism; D000818:Animals; D001219:Aspartate Aminotransferases / Q000378:metabolism; D003900:Desoxycorticosterone / Q000494:pharmacology; D004338:Drug Combinations; D004789:Enzyme Activation / Q000187:drug effects; D006854:Hydrocortisone / Q000494:pharmacology; D007770:L-Lactate Dehydrogenase / Q000378:metabolism; D008099:Liver / Q000166:cytology / Q000187:drug effects* / Q000201:enzymology; D008291:Malate Dehydrogenase / Q000378:metabolism; D008297:Male; D008930:Mitochondria, Liver / Q000187:drug effects / Q000201:enzymology; D009940:Organoids / Q000187:drug effects; D011724:Pyridazines / Q000494:pharmacology; D051381:Rats; D013421:Sulfamethoxypyridazine / Q000494:pharmacology; D013997:Time Factors
D000305:Adrenal Cortex Hormones; D004338:Drug Combinations; D011724:Pyridazines; D003900:Desoxycorticosterone; D007770:L-Lactate Dehydrogenase; D008291:Malate Dehydrogenase; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase; D013421:Sulfamethoxypyridazine; D006854:Hydrocortisone
Vliianie kortikosteroidov na aktivnost' fermentov pechenochnoĭ tkani