Phagocytosis of blood cells by splenic macrophages in thrombotic thrombocytopenic purpura.
A 43-year-old woman who developed thrombotic thrombocytopenic purpura was treated successfully with high doses of prednisone and a splenectomy. Imprints from the cut surface of the spleen showed marked phagocytosis of all the cellular elements of the blood. This observation suggests that hypersplenism, in addition to vascular occlusion, may play a major role in the physiopathology of some cases of thrombotic thrombocytopenic purpura.
D000328:Adult; D001773:Blood Cells / Q000276:immunology*; D002860:Chromium Radioisotopes; D005260:Female; D006801:Humans; D008264:Macrophages / Q000276:immunology*; D010587:Phagocytosis; D011241:Prednisone / Q000627:therapeutic use; D011697:Purpura, Thrombotic Thrombocytopenic / Q000150:complications / Q000276:immunology* / Q000628:therapy; D012640:Seizures / Q000209:etiology; D013154:Spleen / Q000473:pathology; D013163:Splenomegaly / Q000209:etiology
D002860:Chromium Radioisotopes; D011241:Prednisone