[Effect of some N-alkyl-N-NO-carbamyl esters on leukemia L 5222].
Contrary to N-methyl-N-NO-carbamyl esters, two N-ethyl-N-NO-urethanes have shown, at s.c. application, good chemotherapeutic effectiveness on the monocytic-myelogeneous rat leukaemia L 5222. It was possible to achieve definite healing. Single doses of N-ethyl-N-NO-n-butyl-urethane were equally effective as repeatedly applied smaller doses, the rate of curing amounting in both cases to 80 percent. N-Ethyl-N-NO-ethyl-urethane, however, can be compared to N-ethyl-N-NO-n-butyl-urethane only at repeated application. As suggested by orientative experiments, N-ethyl-N-NO-n-butyl urethane acts directly upon leukaemic cells and does not need any activation in the organism. Whether or not splitting by esterases, which are present in the cells of L 5222, should be decisive for the chemotherapeutic effectiveness of these substances can only be elucidated by further investigation. It is yet too early to form a definite opinion on the carcinogenicity of s.c. applied N-ethyl-N-NO-n-butyl-urethane.
D000818:Animals; D004950:Esterases; D005260:Female; D007928:Lethal Dose 50; D007942:Leukemia, Experimental / Q000188:drug therapy*; D008160:Lumbosacral Plexus; D008297:Male; D009442:Neurilemmoma / Q000139:chemically induced; D009603:Nitroso Compounds / Q000009:adverse effects / Q000627:therapeutic use* / Q000633:toxicity; D051381:Rats; D013997:Time Factors; D014520:Urethane / Q000009:adverse effects / Q000031:analogs & derivatives* / Q000627:therapeutic use
D009603:Nitroso Compounds; D014520:Urethane; D004950:Esterases
Wirkung einiger N-Alkyl-N-NO-carbamidsäureester auf die Leukámie L 5222