[Effect of some adrenergic substances on the cumulative effect of strophanthin].
Experiments were conducted on cats; a study was made of the effect of pharmacological block and stimulation of the adrenergic innervation on the toxicity and the cumulative effect of strophanthine. It was found that anapryline premedication and a preliminary reserpinization increased the strophanthine tolerance and reduced its cumulative effect. Isadrine caused a sharp elevation of the sensitivity to cardiac glycoside, but no cumulation was present in this case.
D000818:Animals; D002415:Cats; D004361:Drug Tolerance; D007545:Isoproterenol / Q000494:pharmacology; D007928:Lethal Dose 50; D010042:Ouabain / Q000494:pharmacology / Q000633:toxicity; D011433:Propranolol / Q000494:pharmacology; D011941:Receptors, Adrenergic / Q000187:drug effects*; D012110:Reserpine / Q000494:pharmacology; D013328:Strophanthins / Q000494:pharmacology* / Q000633:toxicity; D013565:Sympatholytics / Q000494:pharmacology*; D013566:Sympathomimetics / Q000494:pharmacology*; D013997:Time Factors
D011941:Receptors, Adrenergic; D013328:Strophanthins; D013565:Sympatholytics; D013566:Sympathomimetics; D010042:Ouabain; D012110:Reserpine; D011433:Propranolol; D007545:Isoproterenol
Vliianie nekotorykh adrenergicheskikh sredstv na kumuliativnyĭ éffekt strofantina