[Effect of antihypertensive agents on the in vitro biosynthesis of prostaglandin E and F2 alpha in the rabbit kidney medulla].
This report describes the influence of antihypertensive drugs on the biosynthesis of prostaglandins from endogenous precursors in the homogenates of rabbit kidney medulla. Dihydralazine and reserpine inhibited, alpha-methyldopa on the contrary stimulated the in vitro biosynthesis of prostaglandins E and F2alpha. Clonidin was without effect. The effects of noradrenaline and indomethacine as standard substances were determined.
D000818:Animals; D000959:Antihypertensive Agents / Q000494:pharmacology*; D003000:Clonidine / Q000494:pharmacology; D004078:Dihydralazine / Q000494:pharmacology; D066298:In Vitro Techniques; D007213:Indomethacin / Q000494:pharmacology; D007668:Kidney / Q000378:metabolism*; D007679:Kidney Medulla / Q000187:drug effects / Q000378:metabolism*; D008750:Methyldopa / Q000494:pharmacology; D009638:Norepinephrine / Q000494:pharmacology; D011458:Prostaglandins E / Q000096:biosynthesis*; D011460:Prostaglandins F / Q000096:biosynthesis*; D011817:Rabbits; D012110:Reserpine / Q000494:pharmacology; D013268:Stimulation, Chemical
D000959:Antihypertensive Agents; D011458:Prostaglandins E; D011460:Prostaglandins F; D008750:Methyldopa; D012110:Reserpine; D003000:Clonidine; D004078:Dihydralazine; D009638:Norepinephrine; D007213:Indomethacin
Einfluss blutdrucksenkender Pharmaka auf die in vitro-Biosynthese der Prostaglandine E und F2alpha im Kaninchennierenmark