Metabolism of sulphadiazine in goats.
1. Following intravenous administration of sulphadiazine (2-sulphailamido-pyrimidine) to goats, unchanged sulphadiazine comprised the major part of the total sulphonamide in blood plasma, milk and urine samples. 2. Relatively small amounts of N4-acetysulphadiazine were excreted in milk and urine. The amount of conjugated metabolites in urine was small, but was comparatively large in the milk samples. 3. A new metabolite, 2-sulphanilamido-4-hydroxyprimidine, which comprised about 15% of the total sulphonamide in urine was isolated.
D000818:Animals; D006041:Goats / Q000378:metabolism*; D008892:Milk / Q000378:metabolism; D013411:Sulfadiazine / Q000031:analogs & derivatives / Q000097:blood / Q000378:metabolism* / Q000652:urine
D013411:Sulfadiazine