Influence of delta9-tetrahydrocannabinol on partial reinforcement effects.
Two experiments were performed with rats trained with either continuous reinforcement (food) or random 50% partial reinforcement for running in a straight alley. Half the rat were trained with daily injections of 0.5 mg/kg delta9-tetrahydrocannabinol (THC) and half with vehicle injections, all animals being extinguished with vehicle injections in Expt. 1 and with THC injections in Expt. 2. The partial reinforcement acquistion effect was abolished by THC during training; the partial reinforcement extinction effect was abolished by THC either during training of during extinction. In these respects THC resembles amylobarbitone and alcohol.
D000818:Animals; D002188:Cannabis / Q000494:pharmacology*; D013759:Dronabinol / Q000494:pharmacology*; D005108:Extinction, Psychological / Q000187:drug effects*; D005639:Frustration; D008297:Male; D051381:Rats; D012055:Reinforcement Schedule; D012054:Reinforcement, Psychology
D013759:Dronabinol