[Acute renal failure after intracranial injury in three children: analysis of possible causes (author's transl)].
In three children (aged 6-8 years)acute renal failure developed three to five days after head injury. After emergency treatment and measures to prevent cerebral oedema, two of the children were given simultaneously dextran, cefalotin, gentaminic and beta-aescin. The dosage of these drugs was much higher than the usual upper limbs, beta-aescin in doses as high as 10 to 20 fold above recommended maximum. There was no proven connection between the drugs and their dosage and renal failure, because many factors were involved. However, in intensive treatment for children an exact control of drug dosage essential because toxic side effects of different drugs can be potentiated. All three children were haemodialysed, renal function recovered and all were discharged without organic sequelae.
D058186:Acute Kidney Injury / Q000139:chemically induced / Q000209:etiology* / Q000628:therapy; D000367:Age Factors; D001929:Brain Edema / Q000517:prevention & control; D001930:Brain Injuries / Q000188:drug therapy / Q000209:etiology*; D002512:Cephalothin / Q000008:administration & dosage / Q000627:therapeutic use; D002648:Child; D003911:Dextrans / Q000008:administration & dosage / Q000627:therapeutic use; D004347:Drug Interactions; D005260:Female; D005839:Gentamicins / Q000008:administration & dosage / Q000627:therapeutic use; D006801:Humans; D008297:Male; D010936:Plant Extracts / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use; D010946:Plants, Medicinal; D006435:Renal Dialysis; D013997:Time Factors
D003911:Dextrans; D005839:Gentamicins; D010936:Plant Extracts; D002512:Cephalothin
Akutes Nierenversagen nach Schädel-Hirn-Trauma bei drei Kindern. Analyse der möglichen Faktoren