Effects of ajmaline and N-propylajmaline on maximum follow frequency and contractility of the dog heart: short communication.
With intravenous infusion in the anesthetized dog N-propylajmaline (NPA) as compared to ajmaline leads to a significantly larger decrease in left ventricular dp/dtmax with equieffective reduction of maximum follow frequency by 25%, and, also in contrast to ajmaline, to a significant increase of left ventricular enddiastolic pressure.
D000404:Ajmaline / Q000031:analogs & derivatives* / Q000494:pharmacology*; D000818:Animals; D001283:Atrioventricular Node / Q000187:drug effects; D001794:Blood Pressure / Q000187:drug effects; D004285:Dogs; D005260:Female; D006329:Heart Conduction System / Q000187:drug effects*; D006339:Heart Rate / Q000187:drug effects; D009200:Myocardial Contraction / Q000187:drug effects*; D012032:Refractory Period, Electrophysiological / Q000187:drug effects
D000404:Ajmaline