Impaired hepatic release of triglycerides: a possible cause of acute alcoholic fatty liver in the Rhesus monkey.
1. The mechanism of development of acute alcoholic fatty liver in the Rhesus monkey was investigated by studying the effect of Triton WR-1339 on plasma triglycerides. 2. After ethanol infusion, the rise in plasma triglyceride produced by Triton was greatly reduced and there was an accumulation of triglyceride in the liver. 3. Thus findings suggest that acute alcoholic fatty liver in Rhesus monkeys is probably due to a defect in the release of triglyceride from the liver.
D000437:Alcoholism / Q000150:complications / Q000378:metabolism*; D000818:Animals; D000431:Ethanol / Q000494:pharmacology; D005234:Fatty Liver / Q000209:etiology* / Q000378:metabolism; D006801:Humans; D008099:Liver / Q000187:drug effects / Q000378:metabolism*; D008253:Macaca mulatta; D011092:Polyethylene Glycols / Q000494:pharmacology; D014280:Triglycerides / Q000097:blood / Q000378:metabolism*
D014280:Triglycerides; D000431:Ethanol; D011092:Polyethylene Glycols