Pharmacokinetic analysis of ampicillin concentration in neonates: comparison of two pharmacokinetic models and of two numerical methods.
Ampicillin blood levels after i.m. injection were analysed according to a one and a two-compartment pharmacokinetic model. The two-compartment model gave no substantially better fit to the data than a one-compartment model. To fit the one-compartment model two computer programs based on different numerical methods, were tested. The BMD program gave satisfactory results in all cases.
D000667:Ampicillin / Q000097:blood*; D001711:Biotransformation; D003201:Computers; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007700:Kinetics; D008954:Models, Biological; D012044:Regression Analysis
D000667:Ampicillin