[Synthesis of virostatically acting N[adamantyl-(1)]-carbonic acid amides].
By introduction of carboxylic acid amide groupings into 1-amino-adamantant (I), remarkable virustatic effects have been obtained, particularly which N-(1-adamantyl) cinnamic acid amide (VIIa) and N-(1-adamantyl)-3-(4'-methoxyphenyl)-acrylic acid amide (VIIc). The synthesis of the N-(1-adamantyl)-carboxylic acid amides (IV, VII, X) could be reallzed by interaction of I with carboxylic acids (II, V, VIII) via the carboxylic acid chlorides (III, VI, IX), the latter not being isolated for the simplification of the process.
D000218:Adamantane / Q000031:analogs & derivatives / Q000138:chemical synthesis*; D000577:Amides / Q000138:chemical synthesis*; D000998:Antiviral Agents / Q000138:chemical synthesis*; D001952:Bridged-Ring Compounds / Q000138:chemical synthesis*; D009682:Magnetic Resonance Spectroscopy; D013055:Spectrophotometry, Infrared
D000577:Amides; D000998:Antiviral Agents; D001952:Bridged-Ring Compounds; D000218:Adamantane
Untersuchungen zur Bildungsweise virustatisch wirksamer N[Adamantyl-(1)]-carbonsäureamide