[Action of valinomycin in vivo on Ehrlich ascites tumor cells. A change in the ultrastructure of the tumor cells under the influence of valinomycin].
It was found with the help of electron microscopy that valinomycin administered to mice with Ehrlich ascitic tumors in a dose inhibiting the proliferating activity induced impairements in the mitochondria. The changes were similar to those under the effect of valinomycin in vitro. An increase in the antibiotic dose resulted in more pronounced and irreversible changes not only in the mitochondria but also in other structures of the tumor cells.
D000818:Animals; D002286:Carcinoma, Ehrlich Tumor / Q000188:drug therapy* / Q000473:pathology; D002467:Cell Nucleus / Q000648:ultrastructure; D003593:Cytoplasm / Q000648:ultrastructure; D004305:Dose-Response Relationship, Drug; D008854:Microscopy, Electron; D008928:Mitochondria / Q000648:ultrastructure; D008933:Mitochondrial Swelling / Q000187:drug effects; D009368:Neoplasm Transplantation; D051381:Rats; D013997:Time Factors; D014634:Valinomycin / Q000494:pharmacology*
D014634:Valinomycin
Deĭstvie valinomitsina in vivo na kletki astsitnoĭ oukholi Erlikha. Izmenenie ul'transtruktury opukholevykh kletok pod vliianiem