Effect of supplements of zinc salts on the healing of incised wounds in the rat and guinea pig.
Zinc deficiency affects healing as shown by measurement of two parameters of wound healing in the rat, namely the rate of healing of an excised, granulating wound and the development of tensile strength in an incised wound. The rate of healing of granulating wounds in two species of animals, the rat and the guinea pig, is not affected by the addition of supplements of zinc salts to the normal diet (J. Nutr. 105, 815-821). In this study, the development of tensile strength in incised wounds in rats and guinea pigs was measured at 7 and 14 days after wounding in animals given supplements of zinc salts by either the oral or parenteral route. No difference in tensile strength was observed at these times in the wounds of either rats or guinea pigs given zinc supplements.
D000284:Administration, Oral; D000824:Animal Nutritional Physiological Phenomena; D000818:Animals; D005260:Female; D006168:Guinea Pigs; D006801:Humans; D007274:Injections, Intraperitoneal; D008297:Male; D051381:Rats; D013045:Species Specificity; D013431:Sulfates / Q000494:pharmacology; D014945:Wound Healing / Q000187:drug effects*; D015032:Zinc / Q000172:deficiency / Q000378:metabolism / Q000494:pharmacology*
D013431:Sulfates; D015032:Zinc