Treatment of schistosomiasis mansoni and japonica in baboons with tubercidin given by direct intravenous injection.
Baboons (Papio cyanocephalus and P. anubis), infected with Schistosoma mansoni or S. japonicum, were treated with single doses of tubercidin (7-deazaadenosine; Tu), 1, 3, and 5 mg per kg of body weight, administered by intravenous drip. Crystalline Tu was dissolved in sterile 0.9% NaCl solution (1 mg per ml), and the solution was delivered at a rate of 4 ml per minute. Detectable short-term host toxicity was limited to the 5 mg per kg dose, mainly in the form of reversible mild to moderate kidney damage. Only this 5 mg per kg dose administered to baboons with relatively heavy S. mansoni infections was capable of completely suppressing fecal egg excretion for 6 to 8 weeks, eliminating the female worms, and terminating active disease, as indicated by histopathological findings. Comparable effects were achieved following the administration of the 3 mg per kg dose to baboons with moderate to heavy S. japonicum infections.
D000818:Animals; D003404:Creatinine / Q000097:blood; D004285:Dogs; D004305:Dose-Response Relationship, Drug; D005243:Feces / Q000469:parasitology; D007275:Injections, Intravenous; D007411:Intestinal Diseases, Parasitic / Q000188:drug therapy; D007668:Kidney / Q000187:drug effects; D007674:Kidney Diseases / Q000139:chemically induced; D008109:Liver Diseases, Parasitic / Q000188:drug therapy; D008297:Male; D010215:Papio; D010270:Parasite Egg Count; D051381:Rats; D012263:Ribonucleosides / Q000627:therapeutic use*; D012547:Schistosoma / Q000187:drug effects; D012552:Schistosomiasis / Q000188:drug therapy*; D014372:Tubercidin / Q000008:administration & dosage / Q000627:therapeutic use* / Q000633:toxicity; D014508:Urea / Q000097:blood
D012263:Ribonucleosides; D014508:Urea; D003404:Creatinine; D014372:Tubercidin