The radiosensitization of hypoxic tumor cells by hyperthermia.
The influence of hyperthermia on the survival of irradiated oxic and hypoxic HeLa cells was determined. A significant reduction in OER was obtained for irradiated cells subsequently cultivated at 42-degrees C for two hours compared to irradiated cells cultivated at 37-degrees C. These results suggest that heating irradiated hypoxic cells is an effective means of reducing the oxygen dependence factor in radiation effects.
D000818:Animals; D002417:Cattle; D002460:Cell Line; D002470:Cell Survival; D003037:Cobalt Radioisotopes; D006367:HeLa Cells / Q000528:radiation effects*; D006358:Hot Temperature; D010100:Oxygen; D011830:Radiation Effects
D003037:Cobalt Radioisotopes; D010100:Oxygen