[Biosynthesis of soluble proteins and pepsinogen of the mucus membrane and cancer of the stomach in man].
Thyrosine-I-C14 and serine-3-C14 show a higher level of incorporation into total soluble proteins of human gastric blastoma hemogenates than those of the mucous membrane. Moreover, a low radioactivity of pepsinogen was detected in the tumors. Also, there was a different rate of incorporation of these aminoacids both into separate fractions of soluble protein and pepsinogen of the mucous membrane and cancer of the stomach. These differences seem to be conditioned by alterations of the process of regulation of protein biosynthesis in the tumors. Simultaneously, there is a direct dependence of the proteolytic activity of pepsin isoforms on the rate of incorporation of the mucous membrane and cancer of human stomach.
D005753:Gastric Mucosa / Q000201:enzymology / Q000378:metabolism*; D006801:Humans; D010435:Pepsinogens / Q000096:biosynthesis*; D014176:Protein Biosynthesis; D012694:Serine / Q000378:metabolism; D013274:Stomach Neoplasms / Q000201:enzymology / Q000378:metabolism*; D014443:Tyrosine / Q000378:metabolism
D010435:Pepsinogens; D014443:Tyrosine; D012694:Serine
Biosintez rastvorimykh belkov i pepsinogena slizistoĭ obolochki i raka zheludka cheloveka