Quantitative measurement of delayed hypersensitivity in the guinea pig paw.
To facilitate quantitative measurement of a delayed hypersensitivity reaction, a tuberculin reaction was produced in the paws of sensitized guinea pigs and the resulting edema estimated by one of the usual techniques. The edema formation was shown to be an expression of the delayed hypersensitivity reaction. Optimal conditions for this reaction were assessed. This model may be used for testing the influence of drugs on delayed hypersensitivity reactions.
D000818:Animals; D004195:Disease Models, Animal; D004487:Edema / Q000473:pathology; D005528:Foot / Q000473:pathology*; D006168:Guinea Pigs; D006968:Hypersensitivity, Delayed / Q000473:pathology*; D008297:Male; D013997:Time Factors; D014374:Tuberculin Test