Intra- and extracellular calcium in Ehrlich ascites tumor cell.
Calcium concentration in intra- and extracellular fluid from Ehrlich ascites tumor cells has been studied. The higher content of calcium in the outer cell fluid appears as a possible factor determining the behavior of the cell membrane. While in the cytoplasm macromolecular compounds such as lipo- and nucleoproteins seem to play an important role in calcium-binding, in the extracellular fluid calcium is likely to be bound to small molecules (presumably short chain polyphosphates). The significance of calcium-binding changes at the cell membrane level in the carcinogenesis and in the physiological behavior of the tumor cells is discussed.
D000818:Animals; D001665:Binding Sites; D002118:Calcium / Q000032:analysis*; D002132:Calcium Radioisotopes; D002286:Carcinoma, Ehrlich Tumor / Q000032:analysis*; D002462:Cell Membrane / Q000032:analysis; D003593:Cytoplasm / Q000032:analysis; D005110:Extracellular Space / Q000032:analysis; D008074:Lipoproteins / Q000032:analysis; D051379:Mice; D008970:Molecular Weight; D009363:Neoplasm Proteins / Q000032:analysis; D009698:Nucleoproteins / Q000032:analysis
D002132:Calcium Radioisotopes; D008074:Lipoproteins; D009363:Neoplasm Proteins; D009698:Nucleoproteins; D002118:Calcium