Regulation of cell cycle stage-specific transcription of histone genes from chromatin by non-histone chromosomal proteins.
RNA transcripts from chromatin of S phase but not G1 cells contain histone-specific sequences. Chromatin reconstituted with S phase non-histone chromosomal proteins transcribes histone messenger RNA sequences whereas chromatin reconstituted with G1 non-histone proteins does not. These results suggest that transcription of histone genes is regulated during the cell cycle and that non-histone proteins have a key role in this regulation.
D002455:Cell Division; D002474:Cell-Free System; D002843:Chromatin / Q000378:metabolism*; D002875:Chromosomes / Q000378:metabolism; D003852:Deoxyribonucleoproteins / Q000378:metabolism*; D006367:HeLa Cells; D006657:Histones / Q000096:biosynthesis*; D009698:Nucleoproteins / Q000378:metabolism*; D014158:Transcription, Genetic
D002843:Chromatin; D003852:Deoxyribonucleoproteins; D006657:Histones; D009698:Nucleoproteins