The central action of intraventricularly (ivc) administered propranolol and phentolamine in rat.
Propranolol (100mug) ivc together with phentolamine (60 mug) decreased spontaneous locomotor activity and weakened post-nialamide locomotor activity in rat. When applied separately in the above doses, neither of the two compounds had this action. Depression of amphetamine-induced locomotor activity was observed after propranolol (250 mug) together with phetolamine (60 mug). Phentolamine alone, had hypothermic action but when applied together with propranolol, it increased after 4 hrs body temperature. The tested compounds prolonged hexobarbital-induced sleeping time but did not affect noradrenaline or dopamine levels in rat's brain.
D000818:Animals; D001831:Body Temperature / Q000187:drug effects; D001923:Brain Chemistry / Q000187:drug effects; D002490:Central Nervous System / Q000187:drug effects*; D004298:Dopamine / Q000032:analysis; D004357:Drug Synergism; D005260:Female; D006591:Hexobarbital / Q000037:antagonists & inhibitors; D007276:Injections, Intraventricular; D008297:Male; D009043:Motor Activity / Q000187:drug effects; D009526:Nialamide / Q000037:antagonists & inhibitors; D009638:Norepinephrine / Q000032:analysis; D010646:Phentolamine / Q000008:administration & dosage / Q000494:pharmacology*; D011433:Propranolol / Q000008:administration & dosage / Q000494:pharmacology*; D051381:Rats
D011433:Propranolol; D006591:Hexobarbital; D009526:Nialamide; D004298:Dopamine; D009638:Norepinephrine; D010646:Phentolamine