Toxicological evaluation of a new benzonaphtyridone derivative (IF C-45).
DL50 for 10-gamma-dimethylaminopropyl-7-chlorobenzo(b)-(1-8)-naphtyridone-5 hydrochloride (IF C-45) determined on several species of animals at different ways of administration, had values similar to those of imipramine and amitryptyline. IF C-45 a-cumulates in 34-4% of A-DL50. The evaluation of chronic toxicity was performed on rats, giving IF C-45 daily for 3 months the doses of 30, 25 and 12-5 mg/kg. The results of hematological, biochemical and histological estimations did not show in these animals any marked toxic effects.
D000410:Alanine Transaminase / Q000097:blood; D000639:Amitriptyline / Q000633:toxicity; D000818:Animals; D001219:Aspartate Aminotransferases / Q000097:blood; D004353:Drug Evaluation, Preclinical; D005260:Female; D007099:Imipramine / Q000633:toxicity; D007928:Lethal Dose 50; D008297:Male; D051379:Mice; D009287:Naphthyridines / Q000008:administration & dosage / Q000633:toxicity*; D011817:Rabbits; D051381:Rats
D009287:Naphthyridines; D000639:Amitriptyline; C006029:benzonaphthyridone; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase; D007099:Imipramine