An abnormality of oestrogen feedback in amenorrhoea-galactorrhoea.
Fourteen patients with amenorrhoea and hyperprolactin-anemia but no evidence of pituitary tumours were each given an intramuscular injection of 1 mg oestradiol benzoate. Thirteen patients failed to release luteinizing hormone in response to the oestrogen. This hypothalamic abnormality may help to explain the menstrual disturbances in subjects with hyperprolactinaemia.
D000568:Amenorrhea / Q000503:physiopathology*; D004958:Estradiol / Q000097:blood / Q000494:pharmacology; D004967:Estrogens / Q000502:physiology*; D005246:Feedback; D005260:Female; D005640:Follicle Stimulating Hormone / Q000097:blood; D005687:Galactorrhea / Q000503:physiopathology*; D006801:Humans; D007775:Lactation Disorders / Q000503:physiopathology*; D007986:Luteinizing Hormone / Q000097:blood / Q000378:metabolism; D011247:Pregnancy; D011374:Progesterone / Q000097:blood; D011388:Prolactin / Q000097:blood; D012636:Secretory Rate / Q000187:drug effects
D004967:Estrogens; D011374:Progesterone; D004958:Estradiol; D011388:Prolactin; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone