Mineral nutrition of Streptomyces kanamyceticus for kanamycin formation.
Kanamycin production by Streptomyces kanamyceticus ATCC 12853 requires magnesium sulfate and potassium phosphate at concentrations of 0.4 and 1.0 g per liter, respectively. The optimal concentrations of Fe and Zn for production of kanamycin are 0.25 and 0.575 mug/ml, respectively, whereas Mo at 0.04 mug/ml allows maximal cellular growth and antibiotic synthesis. Mn and Ca are without any effect. Cu, Co, Ni, and V have inhibitory effect on growth of the organism as well as kanamycin formation.
D002118:Calcium / Q000494:pharmacology; D003470:Culture Media; D007501:Iron / Q000494:pharmacology; D007612:Kanamycin / Q000096:biosynthesis*; D008278:Magnesium Sulfate / Q000494:pharmacology; D008903:Minerals / Q000494:pharmacology*; D008982:Molybdenum / Q000494:pharmacology; D010710:Phosphates / Q000494:pharmacology; D013302:Streptomyces / Q000254:growth & development / Q000378:metabolism*; D015032:Zinc / Q000494:pharmacology
D003470:Culture Media; D008903:Minerals; D010710:Phosphates; D007612:Kanamycin; D008278:Magnesium Sulfate; D008982:Molybdenum; D007501:Iron; D015032:Zinc; D002118:Calcium