[Role of excessive phosphorus consumption in the development of aortic calcinosis].
The calcium and phosphorus content was studied in the blood serum and in the aorta of rats fed with varying Ca:P ratio in their diets (2:1; 1:1; 1:2; 1:3). In rats kept on a 1:3 Ca:P diet hypocalcemia, hyperphosphotemia and intensive calcination of the aorta was observed. Some accumulation of calcium in the aorta was noted also with a 1:2 Ca:P diet. The possible role of excessive phosphorus consumption is discussed as a factor contributing to the development of aortic calcinosis, emphasizing the need to precise and carefully maintain an optimum Ca:P ratio in the diet of normal individuals and in that of cardiovascular patients.
D000821:Animal Feed; D000818:Animals; D001011:Aorta / Q000378:metabolism; D001018:Aortic Diseases / Q000209:etiology*; D002114:Calcinosis / Q000209:etiology*; D002118:Calcium / Q000378:metabolism; D002136:Calcium, Dietary; D004032:Diet / Q000009:adverse effects*; D008297:Male; D010758:Phosphorus / Q000378:metabolism; D051381:Rats
D002136:Calcium, Dietary; D010758:Phosphorus; D002118:Calcium
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