[Effect of ether-oxygen anesthesia and of the premedication agents on the toxicity and cardiotonic effect of strophanthin].
Experiments conducted with mice, rats and cats demonstrated ether-oxygen anesthesia to reduce the tolerance of the animals to strophanthin in the LD50 and MDL tests. The premedication agents (atropine, promedol, diprazine) increased, according to observations on mice and rats, the resistance of the animals to strophanthin. In tests on dogs involving determination of the cardiac ejection by thermodilution strophanthin in a dose of 44 gamma/kg and under ether-oxygen anesthesia with premedication produced a statistically significant increase of the systolic cardiac index and well-marked bradycardia. Exclusion of thepremedicationagents drastically lowered the effect of strophanthin.
D000818:Animals; D002302:Cardiac Output / Q000187:drug effects; D002415:Cats; D004285:Dogs; D004305:Dose-Response Relationship, Drug; D004338:Drug Combinations; D004347:Drug Interactions; D004361:Drug Tolerance; D004986:Ether / Q000494:pharmacology*; D005019:Ethyl Ethers / Q000494:pharmacology*; D006321:Heart / Q000187:drug effects*; D006439:Hemodynamics / Q000187:drug effects; D007928:Lethal Dose 50; D051379:Mice; D010100:Oxygen / Q000494:pharmacology*; D011229:Preanesthetic Medication; D051381:Rats; D013328:Strophanthins / Q000633:toxicity*
D004338:Drug Combinations; D005019:Ethyl Ethers; D013328:Strophanthins; D004986:Ether; D010100:Oxygen
Vliianie éfirno-kislorodmogo narkoza i sredstv premedikatsii na toksichnost' i kardiotonicheskiĭ éffekt strofantina