Antitussive drugs. I. Cardiopulmonary effects of codeine.
In the anesthetized dog, codeine causes a combination of pulmonary vasoconstriction and systemic vasodilation. Pulmonary blood flow is either increased or decreased, relating to a primary stimulation or depression of myocardial contractility. The overall effect is an elevation in pulmonary arterial pressure largely due to vasoconstriction of the pulmonary blood vessels.
D000818:Animals; D001011:Aorta / Q000502:physiology; D001794:Blood Pressure / Q000187:drug effects; D003061:Codeine / Q000008:administration & dosage / Q000494:pharmacology*; D004285:Dogs; D005263:Femoral Artery; D006321:Heart / Q000187:drug effects; D006439:Hemodynamics / Q000187:drug effects*; D007269:Injections, Intra-Arterial; D007275:Injections, Intravenous; D008168:Lung / Q000098:blood supply / Q000187:drug effects*; D009200:Myocardial Contraction / Q000187:drug effects; D011651:Pulmonary Artery; D011652:Pulmonary Circulation / Q000187:drug effects; D012039:Regional Blood Flow / Q000187:drug effects; D014655:Vascular Resistance / Q000187:drug effects
D003061:Codeine