Effect of phototherapy on hepatic excretory function in newborns as measured by bromsulphalein clearance.
BSP clearance from the plasma was studied during phototherapy in a group of jaundice newborns. This therapy did not have any influence on the plasma dye disappearance c curve. The obtained results are consistent with the hypothesis that this therapy causes the photodegradation of bilirubin, and that the increased excretion of unconjugated bilirubin is not mediated by a generalized enhancement of the hepatic output.
D001663:Bilirubin / Q000378:metabolism; D006801:Humans; D007231:Infant, Newborn; D007567:Jaundice, Neonatal / Q000097:blood* / Q000628:therapy; D008099:Liver / Q000378:metabolism; D010789:Phototherapy; D013448:Sulfobromophthalein / Q000097:blood*
D013448:Sulfobromophthalein; D001663:Bilirubin