Facilitation by imidazole of the aqueous flare response to alpha-melanocyte stimulating hormone.
MSH, like traumata to the eye, cause a permeability disturbance in rabbits, with protein leakage into the aqueous. The MSH effect was enormously increased by instillation of imidazole or pilocarpine. The MSH effect seems to engage a different mechanism than the prostaglandin-dependent action of other agents.
D000818:Animals; D001082:Aqueous Humor / Q000032:analysis* / Q000187:drug effects*; D005136:Eye Proteins / Q000032:analysis*; D007093:Imidazoles / Q000494:pharmacology*; D009074:Melanocyte-Stimulating Hormones / Q000494:pharmacology*; D010539:Permeability; D010862:Pilocarpine / Q000494:pharmacology; D011817:Rabbits
D005136:Eye Proteins; D007093:Imidazoles; D010862:Pilocarpine; D009074:Melanocyte-Stimulating Hormones