Analysis of 1-(2-phenyladamant-1-yl)-2-methylaminopropane as its chlorodifluoroacetyl derivative.
The diastereoisomeric content of 1-(2-phenyladamant-1-yl)-2-methylaminopropane can be determined by gas chromatography following treatment with chlorodifluoroacetic anhydride. Racemisation occurs in the synthesis of 2-phenyladamantane from the corresponding 2-chloroadamantane in the Friedel-Crafts reaction with aluminium chloride, but fractionation of the diastereoisomers can occur in the purification steps. A method for determining 2-phenyladamantane in plasma and urine extracts at the nanogram level using an electron-capture detector is described and compared with a previously described radio-assay procedure.
D000218:Adamantane / Q000031:analogs & derivatives / Q000032:analysis* / Q000097:blood / Q000652:urine; D000978:Antiparkinson Agents / Q000032:analysis; D001952:Bridged-Ring Compounds / Q000032:analysis*; D002849:Chromatography, Gas / Q000379:methods; D005463:Fluoroacetates / Q000032:analysis; D006801:Humans
D000978:Antiparkinson Agents; D001952:Bridged-Ring Compounds; D005463:Fluoroacetates; C011327:1-(2-phenyladamant-1-yl)-2-methylaminopropane; D000218:Adamantane