Motivational and neuroanatomical specificity of hypodipsia for aversive solutions produced by medial preoptic injury to the rat.
Bilateral medial preoptic lesions in rats dramatically lowered the rejection threshold for quinine-adulterated water but not for food in 24-hr forced-choice tests. The detection threshold for quinine in a two-bottle choice test, however, was unaffected by the medial preoptic lesion. Bilateral septal and lateral preoptic lesions had no effect on any quinine-adulteration tests. The enhanced rejection of quinine-adulterated water in a forced-choice test by medial-preoptic-damaged rats was also observed after 24-hr of water deprivation. Furthermore, the plasma osmolality of medial preoptic rats was significantly elevated above controls after 24-hr of water deprivation. These findings were interpreted as suggesting that a medial preoptic lesion produces a deficit in thirst-motivated behavior.
D000818:Animals; D001362:Avoidance Learning / Q000502:physiology*; D001833:Body Temperature Regulation; D004327:Drinking Behavior / Q000502:physiology*; D004644:Emotions; D005247:Feeding Behavior / Q000502:physiology; D007031:Hypothalamus / Q000502:physiology*; D009042:Motivation; D009994:Osmolar Concentration; D010949:Plasma; D011301:Preoptic Area / Q000502:physiology*; D011803:Quinine; D051381:Rats; D012688:Septum Pellucidum / Q000502:physiology; D013649:Taste / Q000502:physiology*; D013894:Thirst / Q000502:physiology*; D014868:Water Deprivation
D011803:Quinine