The morphologic effects of simultaneous infusion of levarterenol and phentolamine on the canine myocardium.
The effect of simultaneous administration of levarterenol and phentolamine on the myocardium over a 3 hour period was studied in 15 adult mongrel dogs. All animals receiving levarterenol alone had moderate-to-severe subendocardial hemorrhage and necrosis. Four of the 6 animals receiving the simultaneous infusion of levarterenol and phentolamine had little or no hemorrhage or necrosis. These differences are significant (p less than 0.02). It is concluded that the administration of phentolamine simultaneously with levarterenol affords a significant protective effect on the myocardium.
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D002302:Cardiac Output / Q000187:drug effects; D004285:Dogs; D004347:Drug Interactions; D006321:Heart / Q000187:drug effects*; D006470:Hemorrhage / Q000139:chemically induced; D009336:Necrosis / Q000139:chemically induced; D009638:Norepinephrine / Q000008:administration & dosage / Q000494:pharmacology*; D010646:Phentolamine / Q000008:administration & dosage / Q000494:pharmacology*; D013268:Stimulation, Chemical; D014655:Vascular Resistance / Q000187:drug effects
D009638:Norepinephrine; D010646:Phentolamine