Injectable fluid silicone therapy. Human morbidity and mortality.
Four patients who had received silicone injections had the following complications: migration, hepatic disease manifested as granulomatous hepatitis (previously undescribed, to our knowledge), hypopigmentation, and death. Silicone should now be considered as a possible cause of hepatic granulomas in an appropriate host.
D000328:Adult; D001344:Autopsy; D005260:Female; D006099:Granuloma / Q000139:chemically induced; D006801:Humans; D007267:Injections / Q000009:adverse effects; D008099:Liver / Q000187:drug effects; D008297:Male; D010859:Pigmentation Disorders / Q000139:chemically induced; D011654:Pulmonary Edema / Q000139:chemically induced / Q000473:pathology; D012828:Silicones / Q000009:adverse effects*; D012841:Simethicone / Q000008:administration & dosage / Q000009:adverse effects* / Q000627:therapeutic use; D012867:Skin / Q000187:drug effects; D013518:Surgery, Plastic
D012828:Silicones; D012841:Simethicone