[Acute effect of lidoflazine on the electrocardiographic agitation discharge in atrial frequency stimulation (studies on patients with stress-induced coronary insufficiency)].
Electrocardiographic alterations and onset of angina pectoris during an acute treatment period with lidoflazine -3 to 4 mg/kg b.w. by oral application- was investigated in 20 patients with latent coronary insufficiency under increasing heart rate condition by atrial pacing.  Significant changes in the repolarisation phase mainly due to prolongation of the QTc-interval already appeared 90 to 120 min after oral administration. The onset of test-induced agina pectoris and ischaemic ST-segmental depression in the ECG were not influenced by lidoflazine.  Exceeding a rate of 140 min-1 produced a delay of atrioventricular conduction time under drug influence whereas significant changes of intraventricular conduction did not appear.  Under frequent heart rates bundle branch block developed in a few individuals that might be drug-induced. In addition, there were some signs of digitalis-potentiation by lidoflazine.
D000284:Administration, Oral; D001794:Blood Pressure / Q000187:drug effects; D002036:Bundle of His / Q000187:drug effects; D003327:Coronary Disease / Q000188:drug therapy / Q000503:physiopathology*; D004562:Electrocardiography; D005260:Female; D006321:Heart / Q000187:drug effects; D006339:Heart Rate / Q000187:drug effects*; D006801:Humans; D008013:Lidoflazine / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D008297:Male; D010879:Piperazines / Q000494:pharmacology*
D010879:Piperazines; D008013:Lidoflazine
Der akute Einfluss des Lidoflazins auf den elektrokardiographischen Erregungsablauf bei atrialer Frequenzstimulation (Untersuchungen an Patienten mit Belastungskoronarinsuffizienz)