The influence of the nematode Syphacia oblevata on adjuvant arthritis in the rat.
The effect of infestation with the nematode Syphacia oblevata on adjuvant arthritis was studied in the rat. Animals with an established infestation with Syphacia were found to have a reduced incidence of arthritis after injection of Freund's complete adjuvant. Infested animals developing adjuvant arthritis were found to suffer from a less severe form of the disease than animals in which infestation had been eliminated with piperazine before immunization.
D000818:Animals; D001172:Arthritis, Rheumatoid / Q000150:complications / Q000276:immunology*; D005260:Female; D007114:Immunization; D008297:Male; D009349:Nematode Infections / Q000188:drug therapy; D010123:Oxyuriasis / Q000150:complications / Q000276:immunology*; D010124:Oxyuroidea / Q000276:immunology*; D010879:Piperazines / Q000627:therapeutic use; D051381:Rats; D011919:Rats, Inbred Strains
D010879:Piperazines