Reduction of endotoxin levels in influenza virus vaccines by barium sulfate adsorption-elution.
The level of endotoxin in influenza virus vaccine lots was reduced 10- to 20-fold after barium sulfate adsorption-elution. The amount of viral antigen lost was negligible.
D000327:Adsorption; D000956:Antigens, Viral / Q000032:analysis; D001466:Barium Sulfate; D004340:Drug Contamination; D004731:Endotoxins / Q000302:isolation & purification*; D007252:Influenza Vaccines / Q000302:isolation & purification*; D008722:Methods; D009975:Orthomyxoviridae / Q000276:immunology
D000956:Antigens, Viral; D004731:Endotoxins; D007252:Influenza Vaccines; D001466:Barium Sulfate