Gynandroblastoma of the ovary.
A gynandroblastoma of the ovary in a 17-year-old girl is reported. Primary amenorrhoea, hirsuties and slight clitoral enlargement were associated with the tumour and high levels of circulating testosterone were found. This is the first gynandroblastoma in which Reinke crystalloids have been identified in the Leydig cell component. The criteria for the diagnosis of this tumour and its histogenesis are discussed.
D015065:17-Hydroxycorticosteroids / Q000097:blood; D015068:17-Ketosteroids / Q000097:blood; D000293:Adolescent; D000568:Amenorrhea / Q000209:etiology; D001940:Breast / Q000254:growth & development; D002369:Castration; D002987:Clitoris; D003475:Curettage; D003593:Cytoplasm / Q000032:analysis; D005260:Female; D006628:Hirsutism / Q000209:etiology; D006801:Humans; D006854:Hydrocortisone / Q000097:blood; D007985:Leydig Cells / Q000473:pathology; D008055:Lipids / Q000032:analysis; D008297:Male; D008599:Menstruation Disturbances / Q000209:etiology; D018309:Neoplasms, Gonadal Tissue / Q000150:complications / Q000473:pathology / Q000601:surgery; D010051:Ovarian Neoplasms / Q000150:complications / Q000473:pathology / Q000601:surgery; D012708:Sertoli Cells / Q000473:pathology; D013739:Testosterone / Q000097:blood
D015065:17-Hydroxycorticosteroids; D015068:17-Ketosteroids; D008055:Lipids; D013739:Testosterone; D006854:Hydrocortisone