[Studies on the mechanism of action of peptides attacking smooth muscles. III. The effect of N-azylation on the activity of C-terminal partial sequences of eledoisin, physalaemin and substance P on the guinea pig ileum].
C-terminal pentapeptides of eledoisin, physalaemin, and the substance P, when N-substituted with acetyl, halogenacetyl and other acyl residues, are increased in their action more than  100fold, reaching the activity of acylated hexa- and heptapeptides. The effect found with a number of compounds is interpreted as the influence of predominantly hydrophobic substituents upon the peptide sequence essential for the action. Polar groups in the acylic residue seem to cause additional increase in action.
D000818:Animals; D004600:Eledoisin; D006168:Guinea Pigs; D007082:Ileum / Q000187:drug effects; D009130:Muscle, Smooth / Q000187:drug effects*; D010455:Peptides / Q000494:pharmacology*; D011487:Protein Conformation
D010455:Peptides; D004600:Eledoisin
Studien zum Wirkungsmechanismus glattmuskulär angreifender Peptide III. Der Einfluss der N-Azylierung auf die Wirksamkeit von C-terminalen Teilsequenzen des Eledoisins, des Physalaemins und der Substanz P am Meerschweinchen-Ileum