Urinary kallikrein excretion in a spontaneously hypertensive strain of rats.
Concentration and 24-hr excretion of urinary kallikrein in spontaneous hypertensive Wistar strain rats of both sexes obtained by selected inbreeding (25th generation) are significantly decreased as compared with the excretion in normotensive inbred rats (24th generation) descending from common ancestors. Apparently in these hypertensive rats there is an abnormal capacity of the kidneys to produce or release kallikrein, but more studies will be necessary to correlate this findings with blood pressure increase.
D000818:Animals; D001681:Biological Assay; D001795:Blood Pressure Determination; D003433:Crosses, Genetic; D004950:Esterases / Q000032:analysis; D005260:Female; D006973:Hypertension / Q000503:physiopathology / Q000652:urine*; D007610:Kallikreins / Q000652:urine*; D007705:Kinins / Q000494:pharmacology; D008297:Male; D051381:Rats; D014599:Uterus / Q000378:metabolism
D007705:Kinins; D004950:Esterases; D007610:Kallikreins