Frequent low doses of intravenous mechlorethamine for late-stage mycosis fungoides lymphoma.
Ninety-two courses of daily low-dose intravenous nitrogen mustard were administered to 46 patients with advanced cutaneous lymphomas (mycosis fungoides, Sezary syndrome and lymphoma cutis). Seventy-eight % of patients showed objective clinical remission, and 35% reached a clinically disease-free state following 1 or more courses. The response rate was greater in patients with the plaque-tumor type of mycosis fungoides than in those with erythrodermic variants. Therapy was free of significant side effects.
D000328:Adult; D000368:Aged; D005260:Female; D006801:Humans; D008297:Male; D008466:Mechlorethamine / Q000008:administration & dosage* / Q000627:therapeutic use; D008875:Middle Aged; D009182:Mycosis Fungoides / Q000188:drug therapy*; D012075:Remission, Spontaneous; D012878:Skin Neoplasms / Q000188:drug therapy*
D008466:Mechlorethamine