[On the toxicity of CT-1341 evoked by long-term administration. I. Subacute toxicity of the intravenous anesthetic, CT-1341 in rats (author's transl)].
CT-1341, an intravenous anesthetic was given in various daily doses in rats for a period of one month to test the subacute toxicity. The drug was administered intraperitoneally in rats. Rats tolerated to daily administration of CT-1341 at doses of less than 1.8 ml/kg without showing other particular toxic signs than anesthesia. Main pathological findings were swelling of cells in the liver and renal tubules, and perivascular cuffing in lungs. No severe patho-histological changes were observed in any organs. Mortal cases were seen in the group of rats, in which CT-1341 was given in a daily dose of 5.4 ml/kg. A paralysis of respiratory center was suggested to be cause of death, because no severe patho-histological changes were observed in any organs of mortal rats. Survivals of this group showed no particular symptom except anesthesia, but an inhibition of the growth curve was seen in male rats only.
D000530:Alfaxalone Alfadolone Mixture / Q000008:administration & dosage / Q000633:toxicity*; D000771:Anesthesia, Intravenous; D000818:Animals; D001835:Body Weight / Q000187:drug effects; D001921:Brain / Q000033:anatomy & histology; D002196:Capillaries / Q000187:drug effects; D005260:Female; D007274:Injections, Intraperitoneal; D007668:Kidney / Q000033:anatomy & histology; D007684:Kidney Tubules / Q000473:pathology; D008168:Lung / Q000033:anatomy & histology / Q000473:pathology; D008297:Male; D009929:Organ Size / Q000187:drug effects; D010902:Pituitary Gland / Q000033:anatomy & histology; D011277:Pregnanediones / Q000633:toxicity*; D051381:Rats; D012133:Respiratory Paralysis / Q000139:chemically induced / Q000473:pathology; D012737:Sex Factors; D013154:Spleen / Q000033:anatomy & histology; D013950:Thymus Gland / Q000033:anatomy & histology; D013961:Thyroid Gland / Q000033:anatomy & histology; D013997:Time Factors
D011277:Pregnanediones; D000530:Alfaxalone Alfadolone Mixture