Vitamin B6 deficiency in uremia.
Significant decreases in plasma pyridoxal-5-phosphate (PLP), plasma glutamic-oxaloacetic transaminase (PGOT) and erythrocyte glutamic-oxaloacetic transaminase (EGOT) were found in 29 uremic patients including 14 who had been on hemodialysis an average of 15.8 months. The mean PLP values of the uremic patients (5.39 +/- 0.37 ng/ml) were clearly lower than the values obtained for the normal group (9.30 +/- 0.80 mg/ml). The mean PGOT values of the uremic patients (dialyzed 4.07 +/- 0.29 U/liter, undialyzed 5.31 +/- 0.49 U/liter) were significantly lower than the normal group (6.57 +/- 0.39 U/liter). The mean EGOT value of the uremic patients (325 +/- 17 U/liter) was also lower than normal subjects (416 +/-21 U/liter). Stimulation of the EGOT by exogenous PLP (EGOT index) was less in dialyzed patients (1.60) than normal subjects (1.80) while the undialyzed uremic subjects had a greater than normal stimulation (2.12). All of these results indicate that uremic patients are vitamin B6 deficient and that those undergoing hemodialysis may have decreased amounts of the EGOT apoenzyme.
D000328:Adult; D000368:Aged; D001051:Apoenzymes / Q000097:blood; D001219:Aspartate Aminotransferases / Q000097:blood; D004912:Erythrocytes / Q000378:metabolism; D006801:Humans; D008297:Male; D008875:Middle Aged; D011732:Pyridoxal Phosphate / Q000097:blood; D006435:Renal Dialysis; D014511:Uremia / Q000150:complications / Q000378:metabolism*; D026681:Vitamin B 6 Deficiency / Q000150:complications / Q000209:etiology / Q000378:metabolism*
D001051:Apoenzymes; D011732:Pyridoxal Phosphate; D001219:Aspartate Aminotransferases