The allosteric influence of beta-halo-alkylamines on the acetyl-choline receptor of smooth muscle.
Using the method of receptor blockade by phenoxybenzamine, data have been obtained at the acetylcholine receptor that cannot be explained by a competitive irreversible blockade of the receptors. An allosteric attack of the beta-halo-alkylamines is discussed.
D000109:Acetylcholine / Q000378:metabolism*; D000588:Amines / Q000494:pharmacology*; D000818:Animals; D002217:Carbachol / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D006168:Guinea Pigs; D009130:Muscle, Smooth / Q000187:drug effects*; D010643:Phenoxybenzamine / Q000494:pharmacology; D051381:Rats; D011950:Receptors, Cholinergic / Q000187:drug effects*; D011955:Receptors, Drug / Q000187:drug effects
D000588:Amines; D011950:Receptors, Cholinergic; D011955:Receptors, Drug; D010643:Phenoxybenzamine; D002217:Carbachol; D000109:Acetylcholine