Polysubstituted pyrazoles. Part 2: Sulphonamidophenylhydrazone-2-pyrazolin-4-ones and sulphonamidophenylazopyrazoles as potential anticancer agents.
The synthesis of some new derivatives of 1-[4-nitrophenyl]-5-[4-substituted sulphonamidophenylhydrazono]-2-pyrazolin-4-ones and 3,5-dimethyl-4-[4-substituted sulphonamidophenylazo]-pyrazoles is described. Bromination of ethyl 2-[nitrophenylhydrazono]-3-oxobutyrates in dry benzene afforded the 4-bromo derivatives which upon cyclization gave high yields of the 4-hydroxpyrazoles. Many other new intermediates were prepared and the results of the UV and IR spectral studies are discussed.
D000970:Antineoplastic Agents / Q000138:chemical synthesis*; D001391:Azo Compounds / Q000138:chemical synthesis; D006835:Hydrazones / Q000138:chemical synthesis; D008722:Methods; D011720:Pyrazoles / Q000138:chemical synthesis*; D013055:Spectrophotometry, Infrared; D013056:Spectrophotometry, Ultraviolet; D013449:Sulfonamides / Q000138:chemical synthesis
D000970:Antineoplastic Agents; D001391:Azo Compounds; D006835:Hydrazones; D011720:Pyrazoles; D013449:Sulfonamides