[Deiodase activity in hypothyroid rats].
In rats hypothyroidized with methylthiouracil (MTU), methimazol (MMI), or radiothyroidectomy, the extent of deiodination for L-diiodotyrosine (L-DIT) and L-thyroxine (L-T4) was investigated in homogenate supernatants of liver and kidney. Deiodination in liver and kidney for DIT is twice as high as for T4, but the kidney allows only 25% of the liver deiodination activity both for DIT and T4. In the livers of all hypothyroid animals, iodide splitting both from DIT and T4 is highly significantly reduced by one-half compared with controls. In the kidney of all hypothyroid animals, the DIT deiodination is highly significantly lowered in comparison with controls; the T4 deiodination is significantly reduced only in animals treated with MTU and MMI, and is not significantly enhanced in radiothyroidectomized rats. Thus, there is no difference between MTU and MMI in the extent of deiodination for DIT and T4 in the homogenate supernatants of rat liver or kidney.
D000818:Animals; D001665:Binding Sites; D004105:Diiodotyrosine / Q000378:metabolism; D007037:Hypothyroidism / Q000139:chemically induced / Q000378:metabolism*; D007455:Iodine / Q000378:metabolism*; D007668:Kidney / Q000378:metabolism; D008099:Liver / Q000378:metabolism; D008297:Male; D008713:Methimazole; D008779:Methylthiouracil; D011830:Radiation Effects; D051381:Rats; D013961:Thyroid Gland / Q000528:radiation effects; D013965:Thyroidectomy; D013974:Thyroxine / Q000378:metabolism
D008713:Methimazole; D004105:Diiodotyrosine; D007455:Iodine; D013974:Thyroxine; D008779:Methylthiouracil
Dejodase-Aktivität bei hypothyreoten Ratten