Chromosome-wide event accompanies the expression of recessive mutations in tetraploid cells.
Mutants resistant to 6-thioguanine were induced in pseudotetraploid hybrid Chinese hamster cells homozygous wild-type at the locus for hypoxanthine phophoribosyl transferase but heterozygous for the linked marker glucose-6-phosphate dehydrogenase. About half of these mutants had concomitantly lost the wild-type allele for glucose-6-phosphate dehydrogenase, as expected if mutation plus chromosome segregation had occurred.
D000483:Alleles; D000818:Animals; D002460:Cell Line; D002875:Chromosomes; D006224:Cricetinae; D004351:Drug Resistance; D005260:Female; D005808:Genes, Recessive; D008040:Genetic Linkage; D005838:Genotype; D005954:Glucosephosphate Dehydrogenase / Q000096:biosynthesis; D006822:Hybrid Cells; D007042:Hypoxanthines; D008540:Meiosis; D009154:Mutation; D010053:Ovary; D010430:Pentosyltransferases / Q000096:biosynthesis; D010641:Phenotype; D011123:Polyploidy; D013866:Thioguanine
D007042:Hypoxanthines; D005954:Glucosephosphate Dehydrogenase; D010430:Pentosyltransferases; D013866:Thioguanine