Effect of CB-154 (2 Br-a-ergocryptine) on serum follicle stimulating hormone, luteinzing hormone and prolactin in women with the amenorrhoea-galactorrhoea syndrome.
Four women with the amenorrhoea-galactorrhoea syndrome were treated with 2-Br-a-ergocryptine (CB-154). In 3 patients, lactation was inhibited and ovulation was induced. Furthermore, pregnancy was achieved in one of them. In the remaining case, neither was lactation inhibited nor ovulation induced. Serum follicle stimulating hormone (FSH), luteinizing hormone (LH) and prolactin (PRL) were measured sequentially in the 4 CB- 154 treated women. They showed high serum PRL levels and acyclic patterns of serum FSH and LH. CB-154 suppressed PRL secretion and stimulated FSH and LH secretion in 3 cases where lactation was inhibited and ovulation was induced. In the one unsuccessful case, serum PRL decreased only slightly and the serum FSH and LH showed no marked changes.
D000328:Adult; D000568:Amenorrhea / Q000097:blood / Q000188:drug therapy*; D001971:Bromocriptine / Q000627:therapeutic use*; D003864:Depression, Chemical; D004873:Ergolines / Q000627:therapeutic use*; D004876:Ergot Alkaloids / Q000008:administration & dosage / Q000494:pharmacology; D005260:Female; D005640:Follicle Stimulating Hormone / Q000097:blood*; D005687:Galactorrhea / Q000097:blood / Q000188:drug therapy*; D006801:Humans; D007775:Lactation Disorders / Q000188:drug therapy*; D007986:Luteinizing Hormone / Q000097:blood; D010060:Ovulation / Q000187:drug effects; D011247:Pregnancy; D011388:Prolactin / Q000097:blood*; D013268:Stimulation, Chemical; D013997:Time Factors
D004873:Ergolines; D004876:Ergot Alkaloids; D001971:Bromocriptine; D011388:Prolactin; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone