[Some pharmacological actions of furazan hydrazides and of 2 correspondent furoxan derivatives].
A study has been made of the acute toxicity, action on the guinea pig ileum, on the ventricle edge, on frog spinal reflex, and on the respiratory and cardiac activity and pulse of the following compounds: 3-methyl-4-furazancarbohydrazide (I); 3-methyl-4-furoxancarbohydrazide (II); 4-methyl-3-furoxancarbohydrazide (III). The compounds had no action on guinea pig ileum or ventricle edge. Compound (I) showed depressant activity on frog spinal reflex whereas compound (II) showed excitation and compound (III) had no direct spinal action. The compounds tested affected respiration and ECG only at the highest doses used. The pulse rate was raised by substance (I) in all cases whereas substances (II) and (III) raised pulse rate only at low doses.
D000818:Animals; D001001:Anura; D003497:Cyclic N-Oxides / Q000008:administration & dosage / Q000494:pharmacology* / Q000633:toxicity; D004353:Drug Evaluation, Preclinical; D006168:Guinea Pigs; D006321:Heart / Q000187:drug effects; D007082:Ileum / Q000187:drug effects; D051379:Mice; D010069:Oxadiazoles / Q000008:administration & dosage / Q000494:pharmacology* / Q000633:toxicity; D011674:Pulse / Q000187:drug effects; D012018:Reflex / Q000187:drug effects; D012119:Respiration / Q000187:drug effects
D003497:Cyclic N-Oxides; D010069:Oxadiazoles
Alcune azioni farmacologiche dell'idrazide furazanica e dei due corrispondenti derivati furossanici