Pharmacological approaches to the treatment of morphine-type dependence.
Of the two pharmacologically different possibilities of interfering with the processes of either tolerance or dependence of the morphine type, the so-called maintenance method commonly using methadone is predominantly a matter of tolerance, whereas the blockade with specific opiate antagonists such as cyclazocine intervenes in processes underlying dependence and withdrawal. The experimental evidence for these mechanisms is described.
D003496:Cyclazocine / Q000627:therapeutic use; D004359:Drug Therapy, Combination; D004361:Drug Tolerance; D006801:Humans; D008691:Methadone / Q000627:therapeutic use; D009021:Morphine Dependence / Q000188:drug therapy / Q000534:rehabilitation*; D009270:Naloxone / Q000627:therapeutic use; D009292:Narcotic Antagonists / Q000627:therapeutic use; D013375:Substance Withdrawal Syndrome
D009292:Narcotic Antagonists; D009270:Naloxone; D003496:Cyclazocine; D008691:Methadone