New drug evaluation using exercise-induced bronchospasm.
Exercise-induced asthma was used to demonstrate that a xanthone, a new orally active cromolyn-like drug, has significant activity in man. The effect of a single oral dose of 8 mg/kg was studied in a double-blind corss-over fashion at two and five hours after administration, with significant inhibition of post-exercise bronchospasm being seen at five hours. Further study seems indicated to determine optimal dosage and clinical effectiveness.
D000328:Adult; D001986:Bronchial Spasm / Q000188:drug therapy* / Q000209:etiology; D004341:Drug Evaluation / Q000592:standards; D005541:Forced Expiratory Volume; D006801:Humans; D008450:Maximal Midexpiratory Flow Rate; D005082:Physical Exertion; D011674:Pulse; D014797:Vital Capacity; D014970:Xanthines / Q000627:therapeutic use*
D014970:Xanthines