A rapid test for sickle hemoglobin.
Vigorous shaking of oxygenated sickle hemoglobin (Hb S) in solution causes precipitation of the hemoglobin. This unusual property of Hb S forms the basis of a simple test for the presence of Hb S. Comparison of results of this test with those from cellulose acetate electrophoresis in blood samples from 599 patients showed no false-positive or false-negative results. The group tested included 55 persons with sickling disorders and 47 others with unusual hemoglobin patterns. This test may be used to confirm the presence of Hb S or to establish the diagnosis of sickling disorders rapidly in the clinic or at the bedside.
D000755:Anemia, Sickle Cell / Q000175:diagnosis*; D044383:Black People; D011232:Chemical Precipitation; D004586:Electrophoresis; D005188:False Negative Reactions; D005189:False Positive Reactions; D006451:Hemoglobin, Sickle / Q000032:analysis*; D006455:Hemoglobins, Abnormal / Q000032:analysis*; D006801:Humans; D007258:Informed Consent; D008722:Methods; D010641:Phenotype; D013789:Thalassemia / Q000175:diagnosis
D006451:Hemoglobin, Sickle; D006455:Hemoglobins, Abnormal