Cardiac lesions in rats fed rapeseed oils.
Fully refined rapeseed oils containing different amounts of erucic acid (1.6%, 4.3% and 22.3%) were fed, at 20% by weight of diet, to weanling male and female Sprague-Dawley rats for periods up to 112 days. Transient myocardial lipidosis characterized by accumulation of fat droplets in myocardial fibers was marked in male and female rats fed oxidized and unoxidized rapeseed oil containing 22.3% erucic acid, moderate with rapeseed oil containing 4.3% erucic acid and very slight in rats fed rapeseed oil containing 1.6% erucic acid. Peak intensity of myocardial lipidosis occurred at three to seven days and regressed thereafter. Focal myocardial necrosis and fibrosis occurred in male rats fed rapeseed oils containing different levels of erucic acid for 112 days. The incidence of myocardial necrosis and fibrosis was markedly lower in female rats, and the incidence of these lesions in either sex was not affected by the state of oxidation of these oils. In a second experiment, male rats were fed diets containing crude, partially refined or fully refined rapeseed oils. There was no correlation between the number of foci of myocardial necrosis and fibrosis and the state of refinement of the oils, but there were generally fewer lesions in rats fed those oils having the lowest levels of erucic acid.
D000818:Animals; D009202:Cardiomyopathies / Q000139:chemically induced* / Q000473:pathology; D004883:Erucic Acids / Q000032:analysis; D005231:Fatty Acids, Unsaturated; D005260:Female; D008064:Lipidoses / Q000139:chemically induced* / Q000473:pathology; D008297:Male; D009149:Mustard Plant; D009206:Myocardium / Q000473:pathology; D009336:Necrosis; D009821:Oils / Q000032:analysis; D010946:Plants, Medicinal; D051381:Rats; D012737:Sex Factors; D013025:Glycine max; D013997:Time Factors; D003313:Zea mays
D004883:Erucic Acids; D005231:Fatty Acids, Unsaturated; D009821:Oils