Adenosquamous carcinoma of the liver.
A rare case of adenosquamous carcinoma of the liver is reported. An 85-year-old white man presented with a 6-month history of weight loss and an enlarged liver. A biopsy demonstrated a squamous cell carcinoma which was presumed to be metastatic with an occult primary. At autopsy, the liver was partially replaced by a focally cystic tumor. Histologically, the neoplasm demonstrated both malignant squamous and glandular contradistinctionmponents as well as foci of transition between the two. This is in co to the 5 previous reported cases of primary hepatic squamous cell carcinomas or tumors containing a squamous component. It is suggested that this neoplasm arose from malignant transformation of squamous metaplasia in a pre-existing cholangiocarcinoma.
D000230:Adenocarcinoma / Q000473:pathology*; D000368:Aged; D002294:Carcinoma, Squamous Cell / Q000473:pathology*; D002471:Cell Transformation, Neoplastic; D006801:Humans; D008099:Liver / Q000473:pathology; D008113:Liver Neoplasms / Q000473:pathology*; D008297:Male; D008679:Metaplasia / Q000473:pathology