[Primary pathological changes in cells infected with tick-borne encephalitis virus].
Synthesis and the content of RNA and protein in cells of the pig embryo kidneys infected with tick--borne encephalitis virus were studied by means of autoradiography and cytophotometry. Acceleration of synthesis and accumulation of RNA (in cellular structures) were estimated as over 125--200% of the initial level followed by a decrease in 12 hr when the virus release from the cells occurred. By the 2nd and 6--8th hr of infection (in the period of synthesis of early and late virus material), two peaks of protein contents over 123--131% were observed. The RNA and protein shifts are well correlated with the virus reproduction stages.
D000818:Animals; D001345:Autoradiography; D002460:Cell Line; D002466:Cell Nucleolus / Q000378:metabolism; D002467:Cell Nucleus / Q000378:metabolism; D003588:Cytopathogenic Effect, Viral; D003593:Cytoplasm / Q000378:metabolism; D004669:Encephalitis Viruses, Tick-Borne / Q000254:growth & development*; D007668:Kidney / Q000196:embryology; D014176:Protein Biosynthesis; D012313:RNA / Q000096:biosynthesis*; D013552:Swine; D014316:Tritium; D014529:Uridine; D014779:Virus Replication
D014316:Tritium; D012313:RNA; D014529:Uridine
Pervichnye patologicheskie izmeneniia v kletkakh, zarazhennykh virusom kleshchevogo éntsefalita