Gastric acid secretory differences in patients with Heineke-Mikulicz and Finney pyloroplasties.
To study gastric emptying and secretion, liquid meals of 10% glucose lasting 15 and 30 min, and physiological saline meals lasting 30 min, all containing phenol red as a gastric nonabsorbable marker, were given to postvagotomy patients with Finney or Heineke-Mikulicz pyloroplasties. No differences in emptying were found. A small but statistically greater amount of acid was found in the stomach with the 15-min glucose meal after Heineke-Mikulicz pyloroplasty. This represented greater acid secretion into glucose meals generally after Heineke-Mikulicz pyloroplasties, because of the larger volume contained in the stomach at 15 min. 15-min glucose meal acid secretion correlated with basal acid concentration but not with insulin-stimulated gastric acid output. The small excess of acid in the Heineke-Mikulicz group's 15-min glucose meals may represent a small, maintained excess of gastric acid in this group detected only in the brief glucose meals due to rapid and erratic gastric emptying of liquids after vagotomy.
D005750:Gastric Juice / Q000378:metabolism*; D005769:Gastrointestinal Motility; D006801:Humans; D008297:Male; D010437:Peptic Ulcer / Q000601:surgery*; D011708:Pylorus / Q000601:surgery*; D012008:Recurrence; D013514:Surgical Procedures, Operative / Q000009:adverse effects