m7G5'ppp5'GmptcpUp at the 5' terminus of reovirus messenger RNA.
In the presence of S-adenosyl methionine the 5' terminal guanosine residue of in vitro synthesized reovirus mRNA becomes methylated at the 2'-OH position. In addition, 7-methyl guanylic acid is condensed covalently at the 5' terminus resulting in the formation of a 5' to 5' triphosphate bridge. Analysis of the 5' terminal sequence of methylated reovirus mRNA revealed that it has the structure m7G5'ppp5'GmpCpUp.
D001483:Base Sequence; D055598:Chemical Phenomena; D002621:Chemistry; D003597:Cytosine Nucleotides / Q000032:analysis; D006150:Guanine Nucleotides / Q000032:analysis; D008745:Methylation; D012333:RNA, Messenger; D012367:RNA, Viral; D012087:Reoviridae / Q000032:analysis*; D014500:Uracil Nucleotides / Q000032:analysis
D003597:Cytosine Nucleotides; D006150:Guanine Nucleotides; D012333:RNA, Messenger; D012367:RNA, Viral; D014500:Uracil Nucleotides