Hazards of overconcentrated milk formula.  Hyperosmolality, disseminated intravascular coagulation and gangrene.
Severe hypertonic dehydration with hyperglycemia developed in a 7-week-old infant girl after she was fed an overconcentrated milk formula for five days.  Renal failure,disseminated intravascular coagulation, gangrene of the legs, and coma were added complications.  Intravenous rehydration, peritoneal dialysis, and heparin administration corrected the metabolic and coagulation derangements, and renal function returned to normal.  Bilateral below-the-knee amputations were performed and the child subsequently learned to walk with artificial limbs.  The dangers of overconcentrated formulas in infant feeding should be widely publicized through warnings printed on all commercial milk preparations.
D000367:Age Factors; D000671:Amputation, Surgical; D000818:Animals; D001002:Anuria / Q000209:etiology; D003128:Coma / Q000209:etiology; D003681:Dehydration / Q000209:etiology*; D004211:Disseminated Intravascular Coagulation / Q000209:etiology*; D005260:Female; D005734:Gangrene / Q000209:etiology* / Q000601:surgery; D006801:Humans; D006943:Hyperglycemia / Q000209:etiology*; D007223:Infant; D007225:Infant Food / Q000009:adverse effects*; D007866:Leg / Q000601:surgery; D008892:Milk / Q000009:adverse effects*