In vitro release of chloramphenicol from different suppository bases.
The release of chloramphenicol from different suppository bases has been investigated. It is proved that the release was dependent on drug solubility in the base, solubility of the base in test medium, and the melting point of the base and its chemical composition.
D002626:Chemistry, Pharmaceutical; D002701:Chloramphenicol; D005223:Fats; D005990:Glycerol; D066298:In Vitro Techniques; D010232:Paraffin; D014677:Pharmaceutical Vehicles; D011092:Polyethylene Glycols; D012995:Solubility; D013329:Structure-Activity Relationship; D013488:Suppositories; D013501:Surface-Active Agents; D013997:Time Factors; D014867:Water
D005223:Fats; D014677:Pharmaceutical Vehicles; D013488:Suppositories; D013501:Surface-Active Agents; D014867:Water; D011092:Polyethylene Glycols; D002701:Chloramphenicol; D010232:Paraffin; D005990:Glycerol