[Measurements of blood volume in children with orthostatic syndrome (author's transl)].
The blood volume in 12 children with primary orthostatic syndrome was determined. For six cases it was measured in vertical and horizontal position of the body. Plasma volume was measured by 125J human albumin, erythrocyte volume by 51Cr erythrocytes. In seven cases the values of total blood volume were below the normal values of 68--80 ml/kg body weight when determined in horizontal position. Diminished values were found especially in children suffering from severe orthostatic syndrome. The results indicate the diminution of total blood volume to be an important pathogenetic factor in orthostatic syndrome. In primary orthostatic syndrome it should be differentiated between a hypovolemic type, and a type of predominantly vascular dysregulation. It is suggested that the development of blood volume regulation is delayed. The reduced capacity of the vascular system associated with reduced physical activity could be an additional factor. The active total blood volume increased in all six cases with the change from an upright to a recumbent position. The mean of the difference (3.8 ml/kg body weight) was found to be lower than that in adults. This suggests that sequestration of blood volume is of no evident significance in childhood.
D001811:Blood Volume Determination / Q000379:methods*; D002648:Child; D002860:Chromium Radioisotopes; D004912:Erythrocytes; D005260:Female; D006400:Hematocrit; D006801:Humans; D007024:Hypotension, Orthostatic / Q000150:complications* / Q000175:diagnosis; D008297:Male; D011187:Posture; D012711:Serum Albumin, Radio-Iodinated
D002860:Chromium Radioisotopes; D012711:Serum Albumin, Radio-Iodinated
Blutovolumenbestimmungen bei Kindern mit primärem Orthostase-Syndrom