Effect of weanling malnutrition upon hepatic drug metabolism.
Protein deficiency in post-suckling rats produced changes in the activity of hepatic drug-metabolizing enzymes. Significant decreases occurred in the N-demethylation of aminopyrine, in the azo-reduction of neoprontosil and in sulfokinase activity (using p-nitrophenylsulfate as SO4 donor). An increase was recorded for the glucuronidation of p-nitrophenol and no changes were noted in the hydroxylations of hexobarbital and aniline. Refeeding the animals for 3 weeks returned all activities to control values. An exception was the azo-reductase activity indicating either a slower recovery or a permanent change.
D000632:Aminopyrine / Q000378:metabolism; D000814:Aniline Compounds / Q000378:metabolism; D000818:Animals; D001391:Azo Compounds / Q000378:metabolism; D001711:Biotransformation; D003579:Cytochrome Reductases / Q000378:metabolism; D003580:Cytochromes / Q000378:metabolism; D006591:Hexobarbital / Q000378:metabolism; D008099:Liver / Q000201:enzymology* / Q000378:metabolism; D008297:Male; D009596:Nitrophenols / Q000378:metabolism; D010084:Oxidation-Reduction; D011488:Protein Deficiency / Q000201:enzymology*; D051381:Rats; D013431:Sulfates / Q000378:metabolism
D000814:Aniline Compounds; D001391:Azo Compounds; D003580:Cytochromes; D009596:Nitrophenols; D013431:Sulfates; D000632:Aminopyrine; D006591:Hexobarbital; D003579:Cytochrome Reductases