Airway smooth muscle in exercise-induced bronchospasm: some speculations.
Some possible neurophysiological, biochemical, and pharmacological pathways affecting the state of contractility if airway smooth muscle in exercise-induced bronchospasm (EIB) are described. No unifying hypothesis can be set forth at this time. Indeed, it is likely that the heterogeneous nature of EIB is a reflection of the numerous biochemical loci in smooth muscle cells that could be affected by the various metabolic changes accompanying heavy exertion.
D000109:Acetylcholine / Q000494:pharmacology; D001980:Bronchi; D001986:Bronchial Spasm / Q000209:etiology / Q000378:metabolism*; D003251:Constriction, Pathologic / Q000378:metabolism; D004837:Epinephrine / Q000097:blood; D006801:Humans; D008168:Lung; D009119:Muscle Contraction; D009130:Muscle, Smooth / Q000187:drug effects / Q000378:metabolism* / Q000503:physiopathology; D009638:Norepinephrine / Q000097:blood; D010275:Parasympathetic Nervous System; D005082:Physical Exertion; D013564:Sympathetic Nervous System
D000109:Acetylcholine; D009638:Norepinephrine; D004837:Epinephrine