Methotrexate pneumonitis in a psoriatic.
A life-threatening respiratory disease, characterized by fever, cough, dyspnoea, cyanosis and wide-spread bilateral pulmonary infiltrates, developed in a 40-year-old patient receiving intermittent methotrexate therapy for psoriasis. Blood eosinophilia accompanied the illness. A prominent feature in the clinical picture was a discrepancy between auscultatory findings and the pronounced changes in the chest X-ray. Systemic corticosteroids produced rapid improvement. It is suggested that the pulmonary syndrome represents a hypersensitivity reaction.
D000328:Adult; D004342:Drug Hypersensitivity; D004417:Dyspnea / Q000139:chemically induced; D004802:Eosinophilia / Q000139:chemically induced; D005260:Female; D006801:Humans; D008727:Methotrexate / Q000009:adverse effects* / Q000627:therapeutic use; D011014:Pneumonia / Q000139:chemically induced* / Q000000981:diagnostic imaging; D011565:Psoriasis / Q000188:drug therapy*; D011859:Radiography
D008727:Methotrexate