Inhibition by serum of autoimmune aspermatogenic orchitis.
Inhibition by serum of experimental autoimmune orchitis (EAO) was studied in guinea-pigs. It was found that the capacity of an autoantigen, antigen P, purified from guinea-pigs' spermatozoa, to produce lesions of EAO could be inhibited by mixing antigen P with a small amount of normal human serum before injection into guinea-pigs. In protected animals, cell-mediated immunity and humoral antibodies to antigen P were also significantly suppressed.
D000818:Animals; D000917:Antibody Formation; D001323:Autoantibodies; D001324:Autoantigens; D001327:Autoimmune Diseases / Q000276:immunology* / Q000473:pathology / Q000517:prevention & control; D001769:Blood; D004822:Epididymis / Q000473:pathology; D006168:Guinea Pigs; D006801:Humans; D006968:Hypersensitivity, Delayed; D007111:Immunity, Cellular; D008297:Male; D009920:Orchitis / Q000276:immunology* / Q000473:pathology / Q000517:prevention & control; D013094:Spermatozoa / Q000276:immunology; D013737:Testis / Q000473:pathology
D001323:Autoantibodies; D001324:Autoantigens