Effect of cytochalasin-B on the transport of 5-fluorouracil in cultured mammalian cells.
Cytochalasin-B was found to inhibit the transport of uridine, but not leucine, in cultured fibroblastic mammalian cells. The inhibition of cellular protein synthesis by 5-fluorouracil is also lessened by the addition of Cytochalasin-B to the culture.
D002463:Cell Membrane Permeability / Q000187:drug effects; D002478:Cells, Cultured / Q000187:drug effects / Q000378:metabolism; D003571:Cytochalasin B / Q000494:pharmacology*; D005472:Fluorouracil / Q000378:metabolism*; D005944:Glucosamine / Q000378:metabolism; D007930:Leucine / Q000378:metabolism; D014529:Uridine / Q000378:metabolism
D003571:Cytochalasin B; D007930:Leucine; D005944:Glucosamine; D005472:Fluorouracil; D014529:Uridine