Study of a yeast mutant with modified mitochondrial translocation of adenine nucleotides. II. Synthesis of macromolecules and lipids in the op1 mutant during mutagenesis with ethidium bromide.
A yeast mutant with an impaired system of translocation of adenine nucleotides across the mitochondrial membrane, which stops dividing after superposition of the q- mutation, was investigated. The results of this work indicate that combination of the op1 mutation with the q- mutation in a single cell results in interruption of synthesis of polysaccharides and DNA leading to cessation of division of the op1q- mutant. The mechanism of this effect remains unclear.
D000227:Adenine Nucleotides / Q000378:metabolism*; D002455:Cell Division; D004247:DNA / Q000096:biosynthesis; D004996:Ethidium; D005656:Fungal Proteins / Q000096:biosynthesis; D007700:Kinetics; D008055:Lipids / Q000096:biosynthesis; D008928:Mitochondria / Q000378:metabolism*; D009153:Mutagens; D009154:Mutation; D009696:Nucleic Acids / Q000096:biosynthesis; D011134:Polysaccharides / Q000096:biosynthesis; D012313:RNA / Q000096:biosynthesis; D015003:Yeasts / Q000254:growth & development / Q000378:metabolism*
D000227:Adenine Nucleotides; D005656:Fungal Proteins; D008055:Lipids; D009153:Mutagens; D009696:Nucleic Acids; D011134:Polysaccharides; D012313:RNA; D004247:DNA; D004996:Ethidium