Evaluation of an indirect hemagglutination test for the diagnosis of human leptospirosis.
A presumptive hemagglutination test for the serological diagnosis of leptospirosis in humans is described. The antigen was prepared from a soluble alcohol extract of an andamana strain sorbed to human O-negative erythrocytes and preserved by pyruvic aldehyde fixation. In this study, the overall sensitivity of the hemagglutination test was 92% in contrast to 69% for the presumptive slide agglutination test. The specificity was 95% for the hemagglutination test in comparison with 83% for the slide test.
D000372:Agglutination Tests; D000907:Antibodies, Bacterial / Q000032:analysis; D000918:Antibody Specificity; D003937:Diagnosis, Differential; D005069:Evaluation Studies as Topic; D006386:Hemagglutination Tests / Q000379:methods*; D006801:Humans; D007919:Leptospira / Q000276:immunology; D007922:Leptospirosis / Q000175:diagnosis*
D000907:Antibodies, Bacterial