Catecholamines and exercise-induced glucagon and fatty acid mobilization in the rat.
Physical exercise in rats provokes an increase in plasma glucagon and free fatty acid concentrations. The persistence of exercise-induced glucagon stimulation in adrenodemedullated animals and conversely, its inhibition by immunosympathectomy, (-)-ropranolol, and pindolol substantiate the conclusion that stimulation of the alpha2 cells in exercise involves sympathetic stimulation of the beta-adrenergic receptors. The reduction of free fatty acid mobilization by immunosympathectomy and (-)-propranolol and its persistence after adrenodemedullation suggest that it is similarly mediated, at least in part, by adipose cell beta-sympathetic receptors.
D000273:Adipose Tissue / Q000033:anatomy & histology; D000313:Adrenal Medulla / Q000502:physiology; D000818:Animals; D001786:Blood Glucose; D002395:Catecholamines / Q000032:analysis / Q000494:pharmacology*; D003345:Corticosterone / Q000097:blood; D005230:Fatty Acids, Nonesterified / Q000097:blood / Q000378:metabolism*; D005934:Glucagon / Q000097:blood / Q000378:metabolism*; D013006:Growth Hormone; D007328:Insulin / Q000097:blood; D007498:Iris / Q000294:innervation; D008297:Male; D010179:Pancreas / Q000294:innervation; D005082:Physical Exertion; D010869:Pindolol / Q000494:pharmacology; D011433:Propranolol / Q000494:pharmacology; D051381:Rats; D011941:Receptors, Adrenergic; D013564:Sympathetic Nervous System / Q000502:physiology; D014649:Vas Deferens / Q000294:innervation
D001786:Blood Glucose; D002395:Catecholamines; D005230:Fatty Acids, Nonesterified; D007328:Insulin; D011941:Receptors, Adrenergic; D013006:Growth Hormone; D005934:Glucagon; D011433:Propranolol; D010869:Pindolol; D003345:Corticosterone