An estimate of the turnover rate of bone-derived plasma alkaline phosphatase in Paget's disease.
A through-knee amputation for suspected osteogenic sarcoma was performed on a patient with Paget's disease of the tibia. Plasma alkaline phosphatase (AP) activity fell to normal values, apparently as a single exponential function of time, with a half-life of 1.7 days. The daily turnover of bone-derived plasma AP was estimated to be approximately 200 I.U. from the Pagetic tibia and 20 I.U. from the rest of the skeleton.
D000469:Alkaline Phosphatase / Q000097:blood / Q000378:metabolism*; D001842:Bone and Bones / Q000201:enzymology*; D006207:Half-Life; D006801:Humans; D008297:Male; D008875:Middle Aged; D010001:Osteitis Deformans / Q000201:enzymology*; D013977:Tibia
D000469:Alkaline Phosphatase