Involvement of central dopamine in the hyperthermia in rats produced by d-amphetamine.
The effect of amphetamine on the body temperature was studied in 6-hydroxydopamine and pimozide pretreated rats. Amphetamine alone (1, 2.5 and 5 mg/kg) produced a fairly dose-dependent increase in body temperature. The effect was almost totally antagonized by pimozide, and also reduced after pretreatment with 6-hydroxydopamine. These results are discussed with regard to the possible role of central dopamine in mediating amphetamine-induced hyperthermia in rats.
D000818:Animals; D001831:Body Temperature / Q000187:drug effects; D001921:Brain / Q000378:metabolism; D003913:Dextroamphetamine / Q000494:pharmacology*; D004298:Dopamine / Q000378:metabolism / Q000502:physiology*; D005334:Fever / Q000139:chemically induced / Q000503:physiopathology*; D006892:Hydroxydopamines / Q000494:pharmacology; D008297:Male; D009638:Norepinephrine / Q000378:metabolism; D010868:Pimozide / Q000494:pharmacology; D051381:Rats
D006892:Hydroxydopamines; D010868:Pimozide; D003913:Dextroamphetamine; D004298:Dopamine; D009638:Norepinephrine