Interaction of furazolidone with DNA.
DN forms a complex with furazolidone producing thereby a quenching and a bathochromic shift of the drug absorption pattern. The binding isotherm was a non-linear one indicating involvement of more than one binding process in the formation of the furazolidone - DNA complex. The furazolidone - DNA complex inhibited digestion of DNA by DNAase and stabilized DNA against thermal strand separation by a significant degree.
D001665:Binding Sites; D004269:DNA, Bacterial; D005664:Furazolidone; D006358:Hot Temperature; D007700:Kinetics; D008433:Mathematics; D011489:Protein Denaturation; D013053:Spectrophotometry; D013056:Spectrophotometry, Ultraviolet; D014734:Vibrio cholerae
D004269:DNA, Bacterial; D005664:Furazolidone