Electron microscopic observations on the castration-induced X zone in the adrenal cortex of male mice.
The secondary X zone induced by castration in the adrenal cortex of adult male mice was examined by electron microscopy and radioautography with 3H-thymidine. 10-15 days after castration a thin layer of small eosinophilic cells is formed in the inner-most cortex. Such eosinophilic cells contain irregulary shaped nuclei and spherical or ellipsoidal mitochondria with tubulolamellar cristae, 20-25 days after castration a prominent zone of small eosinophilic cells was clearly identified as the secondary X zone. The typical secondary X zone cells were characterized by the formation of peculiar mitochondrial complexes and whorled sER. The X zone cells with their characteristic organelles incorporated 3H-thymidine. The ultrastructure and formation of the secondary X zone were very similar to those of the primary X zone which appears during normal postnatal development. We demonstrate here the capacity of reticularis cells of adult male mice to transform into typical X zone cells following castration.
D000302:Adrenal Cortex / Q000648:ultrastructure*; D000311:Adrenal Glands / Q000648:ultrastructure*; D000818:Animals; D001345:Autoradiography; D002369:Castration; D002455:Cell Division; D004721:Endoplasmic Reticulum / Q000648:ultrastructure; D008055:Lipids / Q000032:analysis; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D008928:Mitochondria / Q000648:ultrastructure
D008055:Lipids