HL-A W27 in psoriatic arthropathy.
Forty subjects with psoriatic arthritis (PA) underwent HL-A tissue typing. HL-A W27 was significantly increased in psoriatic spondylitis (35%), whereas statistical significance was not reached in patients with peripheral arthritis alone, although W27 was present in a frequency greater than in controls. Psoriatic spondylitis (often asymptomatic) occurred in 57% (23 of 40) of our PA patients. Of interest, psoriatic spondylitis was more often W27 negative than W27 positive; nevertheless, W27-positive and W27-negative spondylitis was clinically and radiographically indistinguishable except that W27-positive disease occurred exclusively in males and the duration of the psoriasis.
D000328:Adult; D000818:Animals; D001168:Arthritis / Q000276:immunology*; D005260:Female; D006649:Histocompatibility Antigens; D006650:Histocompatibility Testing; D006801:Humans; D008297:Male; D051379:Mice / Q000276:immunology; D008875:Middle Aged; D011565:Psoriasis / Q000276:immunology*; D011859:Radiography; D012737:Sex Factors; D012756:Sheep / Q000276:immunology; D013166:Spondylitis / Q000000981:diagnostic imaging / Q000276:immunology; D013997:Time Factors
D006649:Histocompatibility Antigens