Systemic allergic reaction to initial insulin therapy in a juvenile diabetic. Enhanced blast transformation to insulin.
A 14-year-old girl with recent onset of diabetes developed a severe systemic allergic reaction to beef-pork insulin on the third day of insulin therapy. The same reaction developed following the injection of pork insulin and monocomponent insulin. The patient was induced to tolerate pork insulin by systemic desensitization to this insulin over an interval of 6 days. Peripheral blood lymphocytes from the patient cultured in the presence of insulin responded by increased blast cell transformation, as compared with controls, who either had previously presented local allergic reactions to insulin or never had manifested insulin allergy.
D000293:Adolescent; D003888:Desensitization, Immunologic; D003922:Diabetes Mellitus, Type 1 / Q000188:drug therapy* / Q000276:immunology; D004342:Drug Hypersensitivity; D005260:Female; D006801:Humans; D007328:Insulin / Q000009:adverse effects* / Q000627:therapeutic use; D008213:Lymphocyte Activation; D008214:Lymphocytes / Q000276:immunology
D007328:Insulin