Age-dependent rapid antiinsulin effect of hydrocortisone hemisuccinate during insulin induced hypoglycemia in white rat.
The effect of hydrocortisone hemisuccinate upon the intravenous insulin-induced hypoglycemia in various age-groups of white rats was studied. Insulin was injected intravenously in a dose of 10-(2) units per 100 g b.w. in the same age-groups of animals in a basal state, and 2 days later, 15 minutes after the i.p. administration of hydrocortisone hemisuccinate (0.5 mg/100 g b.w.). It has been estabished, that hydrocortisone hemisuccinate had a rapid anti-insulin effect, which is quantitatively different in dependence on the age of animals.
D000367:Age Factors; D000818:Animals; D006854:Hydrocortisone / Q000031:analogs & derivatives* / Q000494:pharmacology; D007003:Hypoglycemia / Q000139:chemically induced*; D007328:Insulin; D007329:Insulin Antagonists; D008297:Male; D051381:Rats
D007328:Insulin; D007329:Insulin Antagonists; D006854:Hydrocortisone