Thiopental and succinylcholine: Action on intraocular pressure.
Intraocular pressure (IOP) measurements were made in a series of 92 male surgical patients, to assess the effects of timing and dosage of succinylcholine given after a standardized sleep dose of thiopental (3 mg./kg.). The major findings of this study were as follows: (1) thiopental alone lowered IOP; (2) a small (0.5 mg./kg.) dose of succinylcholine, given immediately after thiopental, returned IOP to normal; (3) a large (1 mg./kg.) dose of succinylcholine immediately after thiopental maintained the IOP at a low value; (4) if 2 minutes elapsed between thiopental and 1 mg./kg. of succinylcholine, the relaxant raised the IOP to slightly above preanesthetic control values; (5) tracheal intubation caused a significant rise in IOP, more than any effect from succinylcholine itself; (6) succinylcholine drip (0.1 percent), begun after establishment of satisfactory endotracheal halothane-nitrous oxide anesthesia, caused significant IOP elevation in 4 of 11 patients.
D000328:Adult; D000368:Aged; D000770:Anesthesia, Endotracheal; D000771:Anesthesia, Intravenous; D003975:Diazepam; D006801:Humans; D007429:Intraocular Pressure / Q000187:drug effects*; D007442:Intubation, Intratracheal; D008297:Male; D008875:Middle Aged; D009020:Morphine; D009609:Nitrous Oxide; D011229:Preanesthetic Medication; D013390:Succinylcholine / Q000008:administration & dosage / Q000494:pharmacology*; D013874:Thiopental / Q000494:pharmacology*; D013997:Time Factors; D014065:Tonometry, Ocular
D009020:Morphine; D013390:Succinylcholine; D013874:Thiopental; D009609:Nitrous Oxide; D003975:Diazepam