[Stability of amphetaminil. 1. In-vitro studies].
The decomposition of alpha-phenyl-alpha-N-(beta-phenyl-isopropyl)-aminoacetonitrile (amphetaminil, AN 1¿) in different solvent mixtures seems to depend on their polarity. The rate of hydrolysis of amphetaminil is much higher when the compound is dissolved in a methanol/0.1 N HCl (75/25; v/v) or in methanol containing traces of concentrated HCl (36%) (97.5/2.5; v/v). Using radioactively labelled amphetaminil we were able to demonstrate the decomposition of the compound on TLC plates coated with silica gel--independent from the solvent applied. When plates with cellulose as stationary phase were used for chromatography, amphetaminil proved to be stable in cyclohexan/ethylacetate but underwent decomposition in more polar solvents, for example, methanol and chloroform, respectively.
D000607:Aminoacetonitrile / Q000031:analogs & derivatives; D002849:Chromatography, Gas; D002855:Chromatography, Thin Layer; D004355:Drug Stability; D006868:Hydrolysis; D009682:Magnetic Resonance Spectroscopy; D000432:Methanol; D011437:Propylamines; D012997:Solvents; D013055:Spectrophotometry, Infrared; D013997:Time Factors; D014316:Tritium
D011437:Propylamines; D012997:Solvents; D014316:Tritium; D000607:Aminoacetonitrile; D000432:Methanol
Untersuchungen zur Stabilität von Amphetaminil. 1. Mitteilung: In-vitro-Untersuchungen