The influence of a new benzonaphtyridone derivative (IFC-45) with antidepressant activity on the central nervous system. Part I. The influence on behaviour and bioelectrical activity of brain.
IFC-45 (10-(3-dimethylaminopropyl)-7-chlorobenzo-[b]-[1,8] naphtyridone-5 monohydrochloride) in small doses, similarly as imipramine and amitryptyline, did not influence animal behaviour. In higher doses it stimulated excitability of animals while imipramine and amitryptyline appeared to have inhibiting action. After IFC-45, desynchronization in EEG was obtained whereas both imipramine and amitryptiline induced synchronization of EEG.
D000818:Animals; D001362:Avoidance Learning / Q000187:drug effects; D001522:Behavior, Animal / Q000187:drug effects*; D001921:Brain / Q000187:drug effects* / Q000502:physiology; D002415:Cats; D055598:Chemical Phenomena; D002621:Chemistry; D005071:Evoked Potentials / Q000187:drug effects*; D051379:Mice; D009129:Muscle Tonus / Q000187:drug effects; D009287:Naphthyridines / Q000494:pharmacology*; D011817:Rabbits; D051381:Rats
D009287:Naphthyridines