Effects of the diethyl and dimethyl esters of glutamic acid on morphine anti-nociception in the rat.
The effects of pretreatments with various doses of glutamic acid diethyl or dimethyl esters on morphine-induced anti-nociception in the hot-plate and tail-flick tests on rats were examined. While neither substance alone altered control reaction times, they both antagonized the effects of morphine, suggesting the possible involvement of glutamate receptors in narcotic "analgesia". However, several aspects of the data inveigh against the significance of the findings with regard to narcotic mechanisms.
D000700:Analgesics; D000818:Animals; D005971:Glutamates / Q000008:administration & dosage / Q000494:pharmacology*; D007276:Injections, Intraventricular; D008297:Male; D009020:Morphine / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D051381:Rats; D011930:Reaction Time / Q000187:drug effects; D013997:Time Factors
D000700:Analgesics; D005971:Glutamates; D009020:Morphine