The capillary permeability of the rete mirabile of the eel, Anguilla vulgaris L.
Direct measurements of transcapillary exchange during steady-state conditions have been performed in the rete mirabile of the eel. The capillaries were found to be more than 30 times as permeable to THO (PTHO = 33.2 times 10(-5) cm sec-1), ethanol and antipyrine than to K+. The mutual relationship of the permeabilities for K+, Na+, urea and sucrose were similar to that between the corresponding free diffusion coefficients in water. The permeability characteristics did not change when the perfusate contained metabolic inhibitors. Additional of 1 mM/l of albumin lead to a significant transcapillary osmotic flow. NaCl, urea and sucrose, however, did not cause osmotic flow. Based on the quantitative values for permeability and volume flow the capillary pores should be about 1300 A and have a frequency of 1.3 times 10(6) per cm2 of the capillary surface, occupying an area of about 0.1% of the total area. The results obtained in the present investigation raise questions as to the validity of the Pappenheimer single-pore theory for transcapillary transport as well as to the fine structure of the capillary pores. As an alternative to Pappenheimer's theory a multi-pathway model is proposed in order to explain transcapillary transport.
D000811:Anguilla / Q000502:physiology*; D000818:Animals; D000983:Antipyrine / Q000494:pharmacology; D002199:Capillary Permeability / Q000187:drug effects*; D003911:Dextrans / Q000494:pharmacology; D000431:Ethanol / Q000494:pharmacology; D008954:Models, Biological; D009995:Osmosis; D010208:Papaverine / Q000494:pharmacology; D010477:Perfusion; D011188:Potassium / Q000494:pharmacology; D012964:Sodium / Q000494:pharmacology; D013395:Sucrose / Q000494:pharmacology; D013997:Time Factors; D014508:Urea / Q000494:pharmacology
D003911:Dextrans; D000431:Ethanol; D013395:Sucrose; D014508:Urea; D012964:Sodium; D010208:Papaverine; D011188:Potassium; D000983:Antipyrine