Inhibition of human chlorionic gonadotrophin-induced ovarian and uterine growth in the mouse by synthetic arginine vasotocin-1.
21-day-old Swiss-Webster female mice were injected with 1 IU HCG at 09.00 h. Injection of freshly prepared arginine vasotocin (2 mug/0.1 ml/injection) every 12 h inhibited the HCG-induced hypertrophy of the ovaries at 36, 48, 60 and 72 hr after HCG-treatment while the uterine weight was depressed at 60 and 72 h.
D000818:Animals; D006063:Chorionic Gonadotropin / Q000037:antagonists & inhibitors*; D002940:Circadian Rhythm / Q000187:drug effects; D005260:Female; D051379:Mice; D009929:Organ Size; D010053:Ovary / Q000033:anatomy & histology / Q000187:drug effects* / Q000254:growth & development; D014599:Uterus / Q000033:anatomy & histology / Q000187:drug effects* / Q000254:growth & development; D014668:Vasotocin / Q000494:pharmacology*
D006063:Chorionic Gonadotropin; D014668:Vasotocin