An animal model of the compartmental syndrome.
An animal model of the compartmental syndrome is presented to study the effect of elevated intracompartmental pressure on muscle histology and nutrient blood flow. Latex balloons were inserted into the anterior compartment of rabbits and the pressure within them controlled by an adjustable water column. Nutrient blood flow to the muscles of the compartment was determined by an Rb86 isotope dilution technique and showed a progressive decline with intracompartmental pressures over 50 mm Hg. At 80 mm Hg, flow was but 5 per cent of control values. An inflammatory necrosis was noted when a pressure of 60 mm Hg was exerted for 24 hours. At higher pressures an ischemic necrosis without inflammation was observed.
D000818:Animals; D000868:Anterior Compartment Syndrome / Q000473:pathology; D004195:Disease Models, Animal; D007511:Ischemia / Q000473:pathology*; D009132:Muscles / Q000098:blood supply / Q000473:pathology*; D009135:Muscular Diseases / Q000473:pathology*; D011312:Pressure; D011817:Rabbits; D012039:Regional Blood Flow