Influence of the vaccine Polyvaccinum mite on the nasal mucosa.
The necessity of prolonged administration of the vaccine Polyvaccinum prompted this study on the effect of the preserving agent on the nasal mucosa. Buffered physiologic saline solution containing 0.1--0.4% phenol, and the vaccine containing 0.1--0.4% phenol or 0.01% merthiolate were applied for 12 weeks on the nasal mucosa of rabbits. The nasal mucosa, parenchymal organs and adrenals were studied macroscopically and histologically, and immunologic studies were made. On the basis of the results, preservation of Polyvaccinum mite with 0.4% phenol is suggested.
D000281:Administration, Intranasal; D000818:Animals; D000917:Antibody Formation; D007070:Immunoglobulin A / Q000032:analysis; D007074:Immunoglobulin G / Q000032:analysis; D009297:Nasal Mucosa / Q000187:drug effects*; D010592:Pharmaceutic Aids / Q000494:pharmacology*; D010636:Phenols / Q000008:administration & dosage / Q000494:pharmacology; D011310:Preservatives, Pharmaceutical / Q000494:pharmacology*; D011817:Rabbits; D012965:Sodium Chloride / Q000008:administration & dosage; D013849:Thimerosal / Q000008:administration & dosage / Q000494:pharmacology; D014612:Vaccines / Q000592:standards*
D007070:Immunoglobulin A; D007074:Immunoglobulin G; D010592:Pharmaceutic Aids; D010636:Phenols; D011310:Preservatives, Pharmaceutical; D014612:Vaccines; D013849:Thimerosal; D012965:Sodium Chloride