Dietary fat alteration of plasma cholinesterase response to malathion.
This study revealed the influence of organophosphate pesticides on cholinesterase levels of male Sprague-Dawley rats. Subjects were fed fat-free, normal-fat, and high-fat test diets. Sub-acute doses of malathion were given subcutaneously and cholinesterase levels were determined. Malathion was chosen because it is the least toxic of the organophosphate cholinesterase-inhibiting pesticides. Stastical analysis of the data showed that malathion does inhibit blood cholinesterase to the greatest degree in normal-fat diet animals, with the least effect on high-fat groups and fat-free subjects fall in between the two groups.
D000818:Animals; D002802:Cholinesterases / Q000097:blood*; D003864:Depression, Chemical; D004032:Diet; D004041:Dietary Fats / Q000494:pharmacology*; D008294:Malathion / Q000494:pharmacology*; D008297:Male; D051381:Rats; D013997:Time Factors
D004041:Dietary Fats; D002802:Cholinesterases; D008294:Malathion