Tubular sodium handling in cold-exposed man during inhibition of distal tubular reabsorption of sodium.
In 8 healthy volunteers in stable water diuresis, exposed to cold at +15 degrees C for 60 min, changes in excretion and tubular reabsorption of sodium and osmoles were studied by the clearance technique during inhibition of distal tubular sodium reabsorption following chlorothiazide infusion at 2 mg/kg/hr. Inhibition of distal tubular sodium reabsorption by chlorothiazide increased fractional sodium excretion to 6.5% and fractional excretion of osmoles to 7.5% of the filtered amount. The superimposed cold exposure did not further increase these figures, despite a significant cold-induced increase in arterial blood pressure.
D000328:Adult; D001794:Blood Pressure / Q000187:drug effects; D002740:Chlorothiazide / Q000494:pharmacology; D003080:Cold Temperature; D003864:Depression, Chemical; D004231:Diuresis; D005919:Glomerular Filtration Rate / Q000187:drug effects; D006801:Humans; D007668:Kidney / Q000098:blood supply; D007684:Kidney Tubules / Q000378:metabolism*; D008297:Male; D012039:Regional Blood Flow / Q000187:drug effects; D012964:Sodium / Q000378:metabolism* / Q000652:urine; D014867:Water
D014867:Water; D002740:Chlorothiazide; D012964:Sodium