[Growth kinetics of transplantable mammary gland tumors in mice].
The function of: (see article), fits the tumors weight growth for all studied generations in both control and treated animals. Morphological studies show the transplantable tumors in A mice to lose their similarity to a spontaneous tumor--low differentiated adenocarcinoma. Meanwhile, the tumors in C3H mice have a high differentiation level which is typical for the original tumor. 1-nitroso-1-methylurea is very effective against the first generation of tumors in both strains of mice. The tumors response to the drug becomes weaker with further passages. 1-nitroso-1-methyl urea is superior to other nitrous derivatives when used in such tumor models as breast adenocarcinoma in C3H mice.
D000230:Adenocarcinoma / Q000188:drug therapy / Q000503:physiopathology; D000818:Animals; D002471:Cell Transformation, Neoplastic / Q000187:drug effects; D005038:Ethylnitrosourea / Q000627:therapeutic use; D007700:Kinetics; D008297:Male; D008325:Mammary Neoplasms, Experimental / Q000188:drug therapy / Q000503:physiopathology*; D008433:Mathematics; D008770:Methylnitrosourea / Q000627:therapeutic use; D051379:Mice; D008805:Mice, Inbred A; D008809:Mice, Inbred C3H; D009368:Neoplasm Transplantation; D009607:Nitrosourea Compounds / Q000627:therapeutic use; D013997:Time Factors
D009607:Nitrosourea Compounds; D008770:Methylnitrosourea; D005038:Ethylnitrosourea
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