A case of sideroblastic anaemia associated with marked elevation of erythrocytic arginase activity.
Abnormal erythrocytic arginase activity about 30 times higher than normal controls, was found in a 63-year-old male with sideroblastic anaemia. We suggest that an abnormal concentration of arginase in the erythroblasts, in this case reduces the arginine concentration and results in decreased haemoglobin synthesis.
D000596:Amino Acids / Q000097:blood; D000756:Anemia, Sideroblastic / Q000097:blood / Q000201:enzymology*; D001119:Arginase / Q000097:blood*; D004912:Erythrocytes / Q000201:enzymology*; D006801:Humans; D008297:Male; D008875:Middle Aged
D000596:Amino Acids; D001119:Arginase