[Pharmacologic effects in combined use of oxyfedrine and beta-acetyldiogoxin].
In guinea pigs the toxic effect of beta-acetyldigoxin was not increased by simultaneously administered 3-(beta-hydroxy-alpha-methyl-phenethyl-amino)-3'-methoxy-propiophenone (oxy-fedrine). There was no evidence of a potentiation of the glycoside effect by the combination with oxyfedrine (ildamen-Novodigal). The threshold dose for arrhythmia was increased: typical glycoside tachyarrhythmias only occurred after higher infused doses. In anesthetized dogs with heart failure by overdosed pentobarbital, the therapeutic effects of beta-acetyldigoxin were sustained and enhanced by oxyfedrine.
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D002415:Cats; D002496:Central Venous Pressure / Q000187:drug effects; D003326:Coronary Circulation / Q000187:drug effects; D004077:Digoxin / Q000031:analogs & derivatives* / Q000494:pharmacology / Q000633:toxicity; D004285:Dogs; D004347:Drug Interactions; D006168:Guinea Pigs; D006339:Heart Rate / Q000187:drug effects; D006352:Heart Ventricles / Q000187:drug effects; D006439:Hemodynamics / Q000187:drug effects*; D008297:Male; D009200:Myocardial Contraction / Q000187:drug effects; D010099:Oxyfedrine / Q000494:pharmacology* / Q000633:toxicity; D010210:Papillary Muscles / Q000187:drug effects; D011427:Propiophenones / Q000494:pharmacology*; D014655:Vascular Resistance / Q000187:drug effects
D011427:Propiophenones; D004077:Digoxin; D010099:Oxyfedrine
Uber pharmakologische Wirkungen bei der kombinierten Anwendung von Oxyfedrin mit beta-Acetyldigoxin