Effect of maternal protein deprivation on in vitro neonatal intestinal function in rats.
Pregnant rats were fed a 27% (normal) protein diet or an 8% (low) protein diet. The in vitro absorptive capacity of the small intestine of the 2-day-old offspring of these animals was studied. The intracellular accumulations of a prototype amino acid (L-leucine) and sugar (D-galactose) were measured at initial velocity. The offspring of females fed the 8% (low) protein diet demonstrated a 32% decrease in the intracellular accumulation of leucine and a 19% decrease in the intracellular accumulation of galactose. The results are suggestive of a decrease in available transport sites in the offspring of protein-deprived females.
D000818:Animals; D000831:Animals, Newborn; D001692:Biological Transport; D001835:Body Weight; D004044:Dietary Proteins / Q000008:administration & dosage; D005260:Female; D005690:Galactose / Q000378:metabolism; D007408:Intestinal Absorption; D007421:Intestine, Small / Q000503:physiopathology*; D007930:Leucine / Q000378:metabolism; D011247:Pregnancy; D011248:Pregnancy Complications; D011488:Protein Deficiency / Q000503:physiopathology*; D051381:Rats
D004044:Dietary Proteins; D007930:Leucine; D005690:Galactose