Haemoglobin Titusville: alpha94 Asp replaced by Asn. A new haemoglobin with a lowered affinity for oxygen.
A new haemoglobin variant with a decreased oxygen affinity is described, in which the substitution, alpha 94 (G1) Asp replaced by Asn, affects the alpha1beta2 contact alpha1G1-beta2G4. The relevance of this variant to our understanding of the importance of the hydrogen bond between alpha1G1 and beta2G4 in Perutz's model of oxyhaemoglobin A is discussed.
D001216:Asparagine / Q000032:analysis; D001224:Aspartic Acid / Q000032:analysis; D001665:Binding Sites; D002675:Child, Preschool; D005260:Female; D006454:Hemoglobins; D006455:Hemoglobins, Abnormal; D006801:Humans; D007615:Kansas; D007700:Kinetics; D046911:Macromolecular Substances; D010100:Oxygen / Q000097:blood*; D010446:Peptide Fragments / Q000032:analysis; D010833:Phytic Acid / Q000097:blood; D011485:Protein Binding; D013781:Texas
D006454:Hemoglobins; D006455:Hemoglobins, Abnormal; D046911:Macromolecular Substances; D010446:Peptide Fragments; D001224:Aspartic Acid; D001216:Asparagine; D010833:Phytic Acid; D010100:Oxygen