Antiestrogenic activity of 4-methyl-7-hydroxy-6,8-substituted coumarins.
Eight 4-methyl-7-hydroxy-6,8-substituted coumarins were synthesized and evaluated for antiestrogenic activity. All coumarins, possessing approximate LD50 values of 500 - greater than 800 mg/kg, antagonized the uterotropic effects of diethylstilbestrol (DES) in female rats.
D000818:Animals; D003374:Coumarins / Q000494:pharmacology* / Q000633:toxicity; D004054:Diethylstilbestrol / Q000494:pharmacology; D004965:Estrogen Antagonists; D005260:Female; D007928:Lethal Dose 50; D009929:Organ Size / Q000187:drug effects; D051381:Rats; D014599:Uterus / Q000187:drug effects
D003374:Coumarins; D004965:Estrogen Antagonists; D004054:Diethylstilbestrol