Rapid methods for bioavailability determination utilizing urinary excretion data.
Two equations were developed which enable urinary excretion data to be utilized for estimating drug bioavailability within 12 hr-starting between one and two half-lives of the drug, depending upon the relative rates of absorption, distribution, and elimination. Both equations were examined using simulated data for both the one- and two-compartment open models. One equation was tested using literature data with excellent results.
D000042:Absorption; D001682:Biological Availability; D001702:Biopharmaceutics; D005578:Fosfomycin / Q000652:urine; D006207:Half-Life; D008722:Methods; D008954:Models, Biological; D004364:Pharmaceutical Preparations / Q000652:urine*; D013997:Time Factors
D004364:Pharmaceutical Preparations; D005578:Fosfomycin