Metabolism of methocarbamol (robaxin) in the isolated perfused rat liver and identification of glucuronides.
1. Permethylation and g.l.c.-mass spectrometric analysis of bile from an isolated rat liver perfusion to which methocarmol was added showed seven components not present in control bile: methocarbamol, glucuronides of methocarbamol and desmethyl-methocarbamol, and four glucuronides of hydroxylated methocarbamol metabolites. 2. An interesting rearrangement of a methyl group has been found in the mass spectrum of 3-(2-methoxyphenyloxy)-1,2-dimethoxypropane, the permethylation product from methocarbamol.
D000818:Animals; D001646:Bile / Q000378:metabolism; D055598:Chemical Phenomena; D002621:Chemistry; D002849:Chromatography, Gas; D005965:Glucuronates / Q000096:biosynthesis*; D008099:Liver / Q000378:metabolism*; D013058:Mass Spectrometry; D008721:Methocarbamol / Q000378:metabolism*; D010477:Perfusion; D051381:Rats
D005965:Glucuronates; D008721:Methocarbamol