Histamine2 receptors in rat uterus.
Histamine and three histamine analogs (4-methylhistamine, 3-beta-aminoethyl 1,2,4 triazole (TD) and betazole) all produced relaxation in depolarized rat uterine strips. The rank order obtained was the same as that noted previously in the heart and gastric mucosa and the effects of the agonists were blocked by burimamide. The uterine histamine receptor thus appears to be of the H2-type. Adenylate cyclase prepared from the uterus was not stimulated by histamine. Uterine H2-receptors thus do not appear to be associated with adenylate cyclase.
D000262:Adenylyl Cyclases / Q000378:metabolism; D000818:Animals; D004054:Diethylstilbestrol / Q000494:pharmacology; D005260:Female; D006632:Histamine / Q000031:analogs & derivatives / Q000494:pharmacology*; D066298:In Vitro Techniques; D009638:Norepinephrine / Q000494:pharmacology; D051381:Rats; D011955:Receptors, Drug / Q000187:drug effects; D014590:Uterine Contraction / Q000187:drug effects; D014599:Uterus / Q000187:drug effects* / Q000201:enzymology
D011955:Receptors, Drug; D004054:Diethylstilbestrol; D006632:Histamine; D000262:Adenylyl Cyclases; D009638:Norepinephrine