The effect of somatostatin on platelet aggregation.
Somatostatin was infused intravenously over two hours to rabbits in a dose of 1.5 mug/kg min with an initial loading dose of 50 mug/kg. This dose inhibited platelet aggregation in response to both ADP and collagen. Lower doses of SRIF had no effect. The addition of SRIF in vitro to either human or rabbit platelet rich plasma also had no effect on collagen or ADP-induced platelet aggregation.
D000244:Adenosine Diphosphate / Q000378:metabolism; D000818:Animals; D003094:Collagen / Q000378:metabolism; D004305:Dose-Response Relationship, Drug; D006801:Humans; D010974:Platelet Aggregation / Q000187:drug effects*; D011817:Rabbits; D013004:Somatostatin / Q000494:pharmacology*
D013004:Somatostatin; D000244:Adenosine Diphosphate; D003094:Collagen