[Thyroxine depression of compensatory hypertrophy of the thyroid gland in rats of different ages].
It was shown on hemithyroidectomized male rats (2--2.5, 8--10 and 14--16--month-old) that with the advance of age there occurred an increase in the inhibitory effect of the same (as per 100 g of body weight) dose of the exogenous thyroxine on the thyroid compensatory hypertrophy. It is supposed that the threshold of hypothalamo-pituitary-thyroid system to homeostatic inhibition decreased with ageing.
D000367:Age Factors; D000375:Aging / Q000187:drug effects; D000818:Animals; D003864:Depression, Chemical; D006984:Hypertrophy / Q000503:physiopathology; D008297:Male; D009929:Organ Size / Q000187:drug effects; D051381:Rats; D013961:Thyroid Gland / Q000187:drug effects* / Q000502:physiology; D013965:Thyroidectomy; D013974:Thyroxine / Q000494:pharmacology*; D013997:Time Factors
D013974:Thyroxine
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