Stathmokinetic failure to enhance radiation response in human tumours.
The literature concerning the use of metaphase inducing agents as clinical sensitisers to radiation is briefly reviewed, and five cases are reported, which suggest that under ordinary clinical conditions, these agents are not likely to be of value. These results accord with animal experiments and a possible reason is suggested.
D000230:Adenocarcinoma / Q000532:radiotherapy; D000328:Adult; D000368:Aged; D001005:Anus Neoplasms / Q000532:radiotherapy; D002294:Carcinoma, Squamous Cell / Q000532:radiotherapy; D003703:Demecolcine / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D008048:Lip Neoplasms / Q000532:radiotherapy; D008297:Male; D008875:Middle Aged; D008940:Mitotic Index; D009369:Neoplasms / Q000532:radiotherapy*; D011838:Radiation-Sensitizing Agents / Q000627:therapeutic use*; D012878:Skin Neoplasms / Q000532:radiotherapy; D013274:Stomach Neoplasms / Q000532:radiotherapy
D011838:Radiation-Sensitizing Agents; D003703:Demecolcine