Effects of clofibrate in primary biliary cirrhosis hypercholesterolemia and gallstones.
A patient with primary biliary cirrhosis is reported in whom the administration of clofibrate in a dose of 1 g per day for 2 months resulted in a marked increase in hypercholesterolemia, and endoscopic retrograde cholangiography showed multiple intrahepatic gallstones. The stones disappeared 3 months after stopping clofibrate and starting chenodeoxycholic acid in a dose of 125 mg daily. These observations are discussed in relation to the known effects of clofibrate on bile composition.
D002635:Chenodeoxycholic Acid / Q000627:therapeutic use; D002769:Cholelithiasis / Q000139:chemically induced* / Q000188:drug therapy; D002994:Clofibrate / Q000009:adverse effects*; D005260:Female; D006801:Humans; D006937:Hypercholesterolemia / Q000139:chemically induced*; D008103:Liver Cirrhosis / Q000188:drug therapy*; D008875:Middle Aged; D012075:Remission, Spontaneous
D002635:Chenodeoxycholic Acid; D002994:Clofibrate