Biodegradable material for bladder reconstruction.
The objective of this study was to develop a biodegradable material for use in reconstructive surgery of the bladder to serve a temporary function until normal regrowth of the host's tissue is completed. The biodegradable material can serve as a base over which the new bladder can regenerate. At the conclusion of the regrowth of the new tissue, the temporary material could be consumed by the body and therefore not have to be removed. Material evaluation showed that 70% acetic anhydride treated bovine pericardium was digested and dissolved in 4 weeks when implanted subcutaneously in dogs. Based upon this, supplementation of the bladder using this material was performed on 5 dogs. One dog showed urinary leakage and was sacrificed after 1 week. In 3 dogs examined 4, 6, and 48 weeks after implantation, respectively, the implanted material had been dissolved. In one animal autopsied at 10.5 months, a small remnant of the material still remained. Post-operative observation of the animals, excretory pyelocystograms and cystometry confirmed that the material applied was useful for experimental urinary bladder supplementation.
D000085:Acetates / Q000494:pharmacology; D000818:Animals; D001672:Biocompatible Materials; D001673:Biodegradation, Environmental; D002417:Cattle; D003094:Collagen / Q000378:metabolism; D004285:Dogs; D010496:Pericardium / Q000187:drug effects / Q000637:transplantation*; D012038:Regeneration; D014183:Transplantation, Heterologous; D001743:Urinary Bladder / Q000033:anatomy & histology / Q000502:physiology / Q000601:surgery*
D000085:Acetates; D001672:Biocompatible Materials; D003094:Collagen