Evidence that D-glucaro-1,4-lactone shortens the pharmacological action of drugs being disposed via the bile as glucuronides.
D000818:Animals; D001646:Bile / Q000378:metabolism*; D003864:Depression, Chemical; D004347:Drug Interactions; D005937:Glucaric Acid / Q000031:analogs & derivatives / Q000494:pharmacology*; D005965:Glucuronates / Q000378:metabolism*; D005966:Glucuronidase / Q000378:metabolism; D066298:In Vitro Techniques; D007422:Intestines / Q000201:enzymology; D007783:Lactones / Q000494:pharmacology; D008297:Male; D051379:Mice; D009043:Motor Activity / Q000187:drug effects; D004364:Pharmaceutical Preparations / Q000378:metabolism*; D010634:Phenobarbital / Q000378:metabolism / Q000494:pharmacology; D011374:Progesterone / Q000378:metabolism / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D013400:Sugar Acids / Q000494:pharmacology*; D015049:Zoxazolamine / Q000494:pharmacology
D005965:Glucuronates; D007783:Lactones; D004364:Pharmaceutical Preparations; D013400:Sugar Acids; D011374:Progesterone; D015049:Zoxazolamine; D005966:Glucuronidase; D005937:Glucaric Acid; D010634:Phenobarbital