Mechanical responses of rat isolated uterine horns to transmural stimulation.
1 Transmural stimulation of rat isolated uterine horns at low pulse width produced contractions. These were antagonized by hyoscine or tetrodotoxin and potentiated by physostigmine. 2 In the presence of hyoscine, and during bradykinin-induced contractions, transmural stimulation produced inhibition. This inhibition was antagonized by guanethidine, propranolol or tetrodotoxin. 3 Hexamethonium or pempidine did not affect responses to transmural stimulation. 4 It is suggested that transmural stimulation is a method of exciting cholinergic motor and noradrenergic inhibitory postganglionic neurones to the rat myometrium.
D000818:Animals; D001920:Bradykinin / Q000494:pharmacology; D004558:Electric Stimulation; D005260:Female; D006145:Guanethidine / Q000494:pharmacology; D006584:Hexamethonium Compounds / Q000494:pharmacology; D066298:In Vitro Techniques; D010393:Pempidine / Q000494:pharmacology; D011433:Propranolol / Q000494:pharmacology; D051381:Rats; D012601:Scopolamine / Q000494:pharmacology; D013268:Stimulation, Chemical; D013779:Tetrodotoxin / Q000494:pharmacology; D014590:Uterine Contraction / Q000187:drug effects; D014599:Uterus / Q000502:physiology*
D006584:Hexamethonium Compounds; D013779:Tetrodotoxin; D011433:Propranolol; D012601:Scopolamine; D010393:Pempidine; D001920:Bradykinin; D006145:Guanethidine