[Sodium and water balance in the dog under halothane and methoxyflurane anesthesia (author's transl)].
In our model of volume expanded dogs with an equilibrium between input and renal output of sodium and water halothane anesthesia (1,5 Vol.-% insp.) was performed. In deepening halothane anesthesia we found a progressive decrease of mean aortic pressure, GFR and renal sodium and water excretion. There was a strong correlation between GFR and sodium excretion. With a high GFR significantly more sodium was excreted under halothane, whilst reduction of GFR led to an overproportional decrease of sodium excretion. Urine osmolality, too, depended on GFR under halothane. The results of methoxyflurane anesthesia were quite similansion. Concentrations of inorganic fluoride in serum and urine, which we measured in these experiments, did not result in visible changes of sodium or water balance, compared with the conscious state.
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D004285:Dogs; D005260:Female; D005919:Glomerular Filtration Rate / Q000187:drug effects; D006221:Halothane / Q000494:pharmacology*; D008733:Methoxyflurane / Q000494:pharmacology*; D009318:Natriuresis / Q000187:drug effects; D012964:Sodium / Q000378:metabolism*; D013997:Time Factors; D014851:Wakefulness / Q000187:drug effects; D014882:Water-Electrolyte Balance / Q000187:drug effects*
D008733:Methoxyflurane; D012964:Sodium; D006221:Halothane
Natrium- und Wasserbilanz beim Hund im Wachzustand und unter verschiedenen Narkosebedingungen. II. Mitteilung: Halothan- und Methoxyflurannarkose