Enhancement of spontaneous C3H/HeJ mammary tumorigenesis by long-term polyadenylic-polyuridylic acid therapy.
Female C3H/HeJ mice received weekly s.c. injections of 2 mg polyadenylic-polyuridylic acid. Therapy was initiated at either 2 or 9 months of age. In both cases, poly-adenylic-polyuridylic acid-treated animals developed the spontaneous mammary carcinoma associated with this strain more rapidly. Because the opposite result was formerly observed for AKR spontaneous leukemia, the data indicate the polyadenylic-polyuridylic acid has no generalized antineoplastic effect upon spontaneous tumors genetically associated with specific murine strains.
D000818:Animals; D005260:Female; D007279:Injections, Subcutaneous; D008325:Mammary Neoplasms, Experimental / Q000139:chemically induced*; D051379:Mice; D008809:Mice, Inbred C3H; D011063:Poly A-U / Q000008:administration & dosage; D013268:Stimulation, Chemical; D013997:Time Factors
D011063:Poly A-U