Lecithin:cholesterol acyltransferase initial fractional rates of esterification in human and rat serum during development.
The initial fractional rates of cholesterol esterification were measured in human cord serum, in a group of apparently healthy "young adults" (mean age +/- S.D. 32 +/- 5 years), in a group of "middle aged" adults (51 +/- 8 years) with normal coronary angiograms and in newborn, 10-, 20-, 45-, 180- and 365-day-old rats. The initial fractional rate of esterification was inversely related to serum cholesterol levels in humans and, with the exception of newborns, also in rats. A theory of lecithin:cholesterol acyltransferase participation in cholesterol metabolism is discussed.
D000217:Acyltransferases / Q000097:blood*; D000328:Adult; D000367:Age Factors; D000818:Animals; D000831:Animals, Newborn; D005260:Female; D005312:Fetal Blood / Q000201:enzymology; D005333:Fetus; D006801:Humans; D008875:Middle Aged; D007862:Phosphatidylcholine-Sterol O-Acyltransferase / Q000097:blood*; D011247:Pregnancy; D051381:Rats
D000217:Acyltransferases; D007862:Phosphatidylcholine-Sterol O-Acyltransferase