Kinetic amplification of enzyme discrimination.
The dependence of the accuracy of enzymatic systems on the mechanism of the catalyzed reaction is investigated, using a probabilistic approach. Certain mechanisms of reaction, involving a delay in one of the steps act as kinetic amplifiers of molecular discriminations. The relationship between our scheme for a delayed reaction [1] and Hopfield's scheme [i] is discussed.
D004254:DNA Nucleotidyltransferases; D004798:Enzymes; D007700:Kinetics; D008956:Models, Chemical; D011336:Probability; D013329:Structure-Activity Relationship
D004798:Enzymes; D004254:DNA Nucleotidyltransferases