Epidermal growth factor: identification of a new hormone in human urine.
Epidermal growth factor is a polypeptide hormone that was previously identified only in mice. It causes proliferation and keratinization of epidermal tissues. An immune affinity column extraction technique was used to purify partially a substance from human urine which was similar to the mouse hormone in both its biological activity and immunoreactivity.
D000818:Animals; D000937:Antigen-Antibody Reactions; D001667:Binding, Competitive; D001681:Biological Assay; D003315:Cornea; D003429:Cross Reactions; D004848:Epithelium / Q000187:drug effects; D005260:Female; D006133:Growth Substances / Q000494:pharmacology / Q000652:urine*; D006728:Hormones / Q000494:pharmacology / Q000652:urine*; D006801:Humans; D008297:Male; D051379:Mice / Q000276:immunology; D010455:Peptides / Q000302:isolation & purification / Q000494:pharmacology / Q000652:urine*; D011247:Pregnancy; D011863:Radioimmunoassay
D006133:Growth Substances; D006728:Hormones; D010455:Peptides