Dissolution and polymorphism of metolazone.
The solubility and dissolution rate of five different solid forms of 7-chloro-1,2,3,4-tetrahydro-2-methyl-4-oxo-o-tolyl-6-quinazoline-sulfonamide (metolazone) in n-butanol, water and 0.01 n HCl are investigated and thermodynamic values have been computed. The amorphous metolazone dissolves about 8 times faster than the stable modification I (mp. 267-270 degrees C) in 0.01 n HCl at 37 degrees C.
D000440:Butanols; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D004232:Diuretics; D008788:Metolazone; D012995:Solubility; D013816:Thermodynamics; D013997:Time Factors; D014867:Water
D000440:Butanols; D004232:Diuretics; D014867:Water; D008788:Metolazone