Diagnostic value of disaccharide tolerance tests in children.
Diagnostic value of disaccharide tolerance tests in children. Acta Paediatr Scand, 64:693, 1975.--The diagnostic value of oral lactose and sucrose tolerance tests was investigated in 61 children. A total of 105 oral disaccharide tests were carried out. When the rise in blood sugar was low, the same disaccharide was, as a control measure, instilled directly into the small intestine through a tube. This was carried out in 40 cases. In 21 patients the rise in blood sugar following the two forms of administration was correlated with the disaccharidase activity in a peroral small-intestine biopsy. The incidence of false-positive oral lactose tests was between 23 and 30%, that of false-positive oral sucrose tests between 24 and 33%. A border value of 20 mg per 100 ml in the rise of blood glucose within the first hour following a direct intra-intestinal administration affords a very satisfactory distinction between patients with and without disaccharide malabsorption. Blood glucose determinations exceeding one hour were found to be without diagnostic value.
D000293:Adolescent; D001786:Blood Glucose / Q000378:metabolism; D002446:Celiac Disease / Q000175:diagnosis; D002648:Child; D002675:Child, Preschool; D005069:Evaluation Studies as Topic; D005189:False Positive Reactions; D005260:Female; D006801:Humans; D007223:Infant; D007421:Intestine, Small / Q000201:enzymology / Q000378:metabolism; D007785:Lactose / Q000378:metabolism; D007789:Lactose Tolerance Test; D008286:Malabsorption Syndromes / Q000175:diagnosis; D008297:Male; D013393:Sucrase / Q000378:metabolism; D013395:Sucrose / Q000378:metabolism; D013997:Time Factors
D001786:Blood Glucose; D013395:Sucrose; D013393:Sucrase; D007785:Lactose