[Stimulation of the acid secretion of the stomach in rats with and without antrectomy in the perfusion test with betazole].
In the perfusion test of the stomach of rats the stimulation of acid secretion by betazol (Histalog) after one or repeated injections was studied. The experiments yielded the following results: 1. The i.v. injection of 20 mg/kg b.w. betazol was followed by a maximun acid secretion. 2. Another infusion two hours later intensified this effect. The same acid secretion was seen after a small initial dose (5 mg/kg b.w.) half an hour before the infusion of betazol. 3. The i.v. infusion of 30 mg/kg b.w. betazol showed in the intact rat stomach a smaller acid dsecretion response than did the dose of 20 mg/kg b.w. In comparison there was a significant higher stimulation with 30 mg/kg b.w. betzaol in the rat after a distal gastrectomy (antrectomy). 4. One s.c. injection of 50 mg/kg b.w. betazol showed a significant acid response of the parietal cells with a duration of at least 7 h on a percentage comparison.
D000818:Animals; D001625:Betazole / Q000008:administration & dosage / Q000494:pharmacology*; D005743:Gastrectomy; D005750:Gastric Juice / Q000378:metabolism*; D005753:Gastric Mucosa / Q000378:metabolism*; D007263:Infusions, Parenteral; D007275:Injections, Intravenous; D007279:Injections, Subcutaneous; D008297:Male; D010477:Perfusion; D011708:Pylorus / Q000502:physiology; D011720:Pyrazoles / Q000494:pharmacology*; D051381:Rats; D013268:Stimulation, Chemical; D013997:Time Factors
D011720:Pyrazoles; D001625:Betazole
Stimulierung der Säuresekretion des Magens mit und ohne Antrektomie im Perfusionsversuch unter Betazol dei der Ratte.