[Nicotinic acid blood levels after application of xanthinolnicotinate in a new galenic retard preparation].
Nicotinic acid blood level determinations were carried out in 30 male test subjects following application of xantinol-nicotinate in a new galenic retard preparation.  The investigations showed that there is a continuous absorption of the agent--lasting for a longer period--with a maximum of blood level values between the 5th and 7th hour.  In comparative studies with non-retarded xantinol-nicotinate the peak of concentration is already reached 1 h after application.  The use of pharmacokinetic methods showed that by the retardation of xantinol-nicotinate there are no losses of absorption of nicotinic acid--as compared with the non-retarded forms.  By the special galenic properties of the new retard form therapeutically effective nicotinic acid blood levels lasting for more than 8 h with an ascertained biological availability are attained.
D000255:Adenosine Triphosphate / Q000097:blood; D000284:Administration, Oral; D000328:Adult; D000605:Amino Alcohols / Q000008:administration & dosage; D001682:Biological Availability; D002214:Capsules; D003692:Delayed-Action Preparations; D006801:Humans; D007700:Kinetics; D008297:Male; D009539:Nicotinic Acids / Q000008:administration & dosage / Q000032:analysis / Q000097:blood*; D013806:Theophylline / Q000008:administration & dosage / Q000032:analysis; D013997:Time Factors; D014665:Vasodilator Agents / Q000008:administration & dosage / Q000097:blood*; D014970:Xanthines / Q000097:blood*
D000605:Amino Alcohols; D002214:Capsules; D003692:Delayed-Action Preparations; D009539:Nicotinic Acids; D014665:Vasodilator Agents; D014970:Xanthines; D000255:Adenosine Triphosphate; D013806:Theophylline
Nilotinsäure-Blutspiegel nach Applikation von Xantinol-nicotinat in einer neuen galenischen Retary-Präparation