Hereditary factor VII and IX deficiencies in a large kindred.
A large kindred with combined deficiencies of factors VII and IX is presented. The deficiencies appeared to be independent and the data were not consistent with a diagnosis of haemophilia BM. The identification of mildly affected family members, including carriers of haemophilia B and heterozygotes for factor-VII deficiency, was facilitated by comparison with the 95% confidence interval of an age- and sex-matched control population. The bleeding patterns were those of mild to moderate haemophilia B and did not appear to have been modified by the presence of factor-VII deficiency.
D005164:Factor IX / Q000032:analysis; D005167:Factor VII / Q000032:analysis; D005168:Factor VII Deficiency / Q000097:blood* / Q000150:complications / Q000235:genetics; D002836:Hemophilia B / Q000097:blood* / Q000150:complications / Q000235:genetics; D006801:Humans; D008297:Male; D008875:Middle Aged; D010375:Pedigree; D011516:Prothrombin / Q000032:analysis; D013925:Thromboplastin / Q000032:analysis
D005167:Factor VII; D011516:Prothrombin; D005164:Factor IX; D013925:Thromboplastin