A low dose-fractionation shceme for the radiotherapy of carcinoma of the bladder. Experimental background and preliminary results.
Experimental observations are described which form the basis of a low dose-fractionation scheme designed in an attempt to circumvent the problem presented for radiotherapy by the particular radioresistance of poorly oxygenated cells. In a preliminary investigation the scheme was tested in the treatment of carcinoma of the bladder. A total of 45 patients were included in the trial, randomized to be treated according to either of two fractionation schemes. Scheme I : 100 rad 3 times a day, 5 days a week, a total tumor dose of 8 400 rad, 2 weeks of rest in middle of the treatment period. Scheme II : 200 rad once a day, 5 days a week, a total tumor dose of 6 400 rad, 2 weeks of rest in the middle of the treatment period. The results suggest an improved therapeutic ratio with Scheme I in comparison to Scheme II.
D000818:Animals; D002277:Carcinoma / Q000532:radiotherapy*; D006224:Cricetinae; D004307:Dose-Response Relationship, Radiation; D005500:Follow-Up Studies; D006801:Humans; D006931:Hyperbaric Oxygenation; D000860:Hypoxia; D011879:Radiotherapy Dosage; D001749:Urinary Bladder Neoplasms / Q000532:radiotherapy*