Ischemic contracture of the left ventricle. Production and prevention.
Ischemic contracture of the left ventricle ("stone heart") is a recognized complication of prolonged periods of interruption of the coronary circulation during open-heart surgery. We have examined the effects of moderate hypothermia (28 degrees C.) and preoperative beta-adrenergic blockade (propranolol, 0.5 mg. per kilogram; 1.0 mg. per kilogram) on contracture development during ischemic arrest of the heart. Four groups of 8 dogs each were placed on total cardiopulmonary bypass, and ischemic arrest of the heart was produced by cross-clamping the ascending aorta and venting the left ventricle. Intramyocardial carbon dioxide tension was continuously monitored by mass spectrometry. When anaerobic energy production ceased, as indicated by a final plateau in the intramyocardial carbon dioxide accumulation curve, the ischemic arrest was terminated and the contractile state of the heart observed. These results are given in the text. We conclude that beta-adrenergic blockade delays, but does not prevent, the onset of ischemic contracture of the left ventricle under normothermic conditions. Moderate hypothermia appears to prevent this complication completely.
D000818:Animals; D002245:Carbon Dioxide / Q000378:metabolism; D002315:Cardiopulmonary Bypass / Q000009:adverse effects; D003327:Coronary Disease / Q000503:physiopathology / Q000517:prevention & control; D004285:Dogs; D006324:Heart Arrest, Induced / Q000009:adverse effects*; D006352:Heart Ventricles; D007036:Hypothermia, Induced; D009200:Myocardial Contraction; D009206:Myocardium / Q000378:metabolism*; D011433:Propranolol / Q000627:therapeutic use*
D002245:Carbon Dioxide; D011433:Propranolol