Observations on possible autoimmune therapeutic effects in experimentally produced rat bladder tumors.
Autoimmune response to normal and tumor bladder tissues in Fisher/Furth rats were obtained. The reaction consisted mainly of severe pericystitis and hemorrhagic lesions. The cellular infiltrate was predominantly lymphocytic including also plasma cells and histiocytes. Serological tests indicated development of host immunological response. 15 of 33 rat bladder tumors involuted entirely in the course of the autoimmune reaction.
D000818:Animals; D001327:Autoimmune Diseases; D002295:Carcinoma, Transitional Cell / Q000276:immunology* / Q000473:pathology; D005260:Female; D009368:Neoplasm Transplantation; D009374:Neoplasms, Experimental; D051381:Rats; D011916:Rats, Inbred F344; D014182:Transplantation, Autologous; D014185:Transplantation, Isogeneic; D001749:Urinary Bladder Neoplasms / Q000276:immunology* / Q000473:pathology