Mass spectrometric identification of 10,11-dihydro-10,11-dihydroxyprotriptyline in rat urine after administration of protriptyline.
10,11-Dihydro-10,11-dihydroxyprotriptyline was identified in rat urine following administration of protriptyline 40 mg kg-1 i.p. Gas chromatographic-mass spectrometric characterization confirmed the structure of this stable metabolite, and its identity with a synthetic sample.
D000818:Animals; D002849:Chromatography, Gas; D003986:Dibenzocycloheptenes / Q000031:analogs & derivatives*; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D010084:Oxidation-Reduction; D011530:Protriptyline / Q000031:analogs & derivatives* / Q000652:urine; D051381:Rats; D013055:Spectrophotometry, Infrared
D003986:Dibenzocycloheptenes; D011530:Protriptyline