Tryptophane metabolism in bronchial asthma.
Seventeen out of 21 children with severe asthma had an abnormal increase in urinary Kynurenic (KA) and Xanthurenic (XA) acid following oral tryptophane administration. In a second study 11 asthmatic children had significantly greater increases in XA and KA than nine normal healthy children. A micro-assay of KA and XA by column chromatography was performed. The data suggest the presence of a partial block in the metabolism of tryptophane in some children with bronchial asthma.
D000293:Adolescent; D001249:Asthma / Q000378:metabolism*; D002648:Child; D005260:Female; D006801:Humans; D007736:Kynurenic Acid / Q000652:urine; D008297:Male; D011736:Pyridoxine / Q000378:metabolism; D014364:Tryptophan / Q000378:metabolism*; D014977:Xanthurenates / Q000652:urine
D014977:Xanthurenates; D014364:Tryptophan; D007736:Kynurenic Acid; D011736:Pyridoxine