The nature of the collagen cross-links in bone in the chronic uraemic state.
The cross-links from NaB3H4-reduced bone collagen of chronically uraemic rats and pairfed controls were compared. The ratio of the reduced cross-links deltadelta'-dihydroxylysinonorleucine to delta-hydroxylysinonorleucine was significantly increased in the uraemic animals. The observed increment in the dihydroxylysinonorleucine:hydroxylysinonorleucine ratio was accentuated as the uraemic state advanced. The data indicate that osteodystrophy of chronic renal insufficiency is characterized by an alteration of the quantitative relations between cross-links and aldehydic precursors of bone collagen.
D000818:Animals; D001842:Bone and Bones / Q000032:analysis*; D001894:Borohydrides; D055598:Chemical Phenomena; D002621:Chemistry; D003094:Collagen / Q000032:analysis*; D004151:Dipeptides; D005260:Female; D006901:Hydroxylysine / Q000031:analogs & derivatives; D009392:Nephrectomy; D009646:Norleucine / Q000031:analogs & derivatives; D051381:Rats; D014511:Uremia / Q000378:metabolism*
D001894:Borohydrides; D004151:Dipeptides; C010991:delta-hydroxylysylnorleucine; D006901:Hydroxylysine; D009646:Norleucine; D003094:Collagen