Effect of amiloride on digitalis-induced electrocardiographic changes.
In 10 out of the 13 healthy subjects a single oral dose of 1.25 mg of digoxin induced S-T-J depression and T wave flattening in the exercise ECG. Treatment with potassium-sparing diuretic, amiloride, at a dose of 5 mg twice daily for one week reversed the digoxin-induced S-T-J depression but had no effect on the T wave changes.
D000328:Adult; D000584:Amiloride / Q000494:pharmacology*; D003864:Depression, Chemical; D004077:Digoxin / Q000494:pharmacology*; D004341:Drug Evaluation; D004562:Electrocardiography; D005080:Exercise Test; D005260:Female; D006321:Heart / Q000187:drug effects*; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D008297:Male; D011188:Potassium / Q000097:blood; D011719:Pyrazines / Q000494:pharmacology*
D011719:Pyrazines; D004077:Digoxin; D000584:Amiloride; D011188:Potassium