Effect of calcitonin on serum gastrin concentration and component pattern in man.
Synthetic salmon calcitonin (sCT, doses of 0.7 Medical Research Council U per kg) was injected into nine normal subjects and three patients with hypergastrinemia (pemicious anemia). sCT depressed basal as well as food-stimulated serum gastrin concentrations without concomitant changes in total and ultrafiltrable concentrations of calcium in serum. Gel filtration of sera revealed that sCT reduced mainly the small components, III (gastrin-17 or "little" gastrin) and IV (gastrin-13 or "mini"-gastrin).
D000328:Adult; D000368:Aged; D000752:Anemia, Pernicious / Q000097:blood; D000818:Animals; D002116:Calcitonin / Q000494:pharmacology*; D002850:Chromatography, Gel; D003864:Depression, Chemical; D005755:Gastrins / Q000097:blood*; D006801:Humans; D007700:Kinetics; D046911:Macromolecular Substances; D008875:Middle Aged; D012474:Salmon
D005755:Gastrins; D046911:Macromolecular Substances; D002116:Calcitonin