Teratogenicity of cyproheptadine in pregnant rats.
The teratogenicity of cyproheptadine HCL (Periactin) was studied in 3 groups of pregnant rats which received respectively 0.5 mg/kg/day, 2.5 mg/kg/day and 5 mg/kg/day cyproheptadine subcutaneously and in a control group of pregnant rats which received 0.2 ml/day of the solvent normal saline. Higher doses were toxic to pregnant rats. There was no significant difference in the birth rate, foetal resorption rate and malformation rate between the 4 groups. Moreover, there was no significant difference between average weights, average foetal placental weights and male/female ratio in the experimental and control foetuses. It is concluded that cyproheptadine is devoid of any teratogenic effect in rats.
D000014:Abnormalities, Drug-Induced / Q000209:etiology; D000818:Animals; D001724:Birth Weight / Q000187:drug effects; D003533:Cyproheptadine / Q000494:pharmacology*; D005260:Female; D005327:Fetal Resorption / Q000188:drug therapy; D005333:Fetus / Q000187:drug effects; D008297:Male; D051379:Mice; D011247:Pregnancy; D011270:Pregnancy, Animal; D051381:Rats; D012744:Sex Ratio / Q000187:drug effects; D013723:Teratogens / Q000494:pharmacology*
D013723:Teratogens; D003533:Cyproheptadine