Calcium-induced damage of rat heart mitochondria.
The damage which may be caused to heart mitochondria by the rapid uptake of calcium when oxygen is restored after a period of anoxia is monitored by the deterioration in phosphorylation performance. Methods of protecting mitochondria from this damage by preventing calcium uptake and by chelating cytoplasmic calcium are considered.
D000255:Adenosine Triphosphate / Q000032:analysis; D000818:Animals; D002118:Calcium / Q000378:metabolism*; D002951:Citrates / Q000494:pharmacology; D003593:Cytoplasm / Q000378:metabolism; D066298:In Vitro Techniques; D008931:Mitochondria, Muscle / Q000378:metabolism*; D009206:Myocardium / Q000378:metabolism*; D010100:Oxygen; D010728:Phosphoenolpyruvate / Q000494:pharmacology; D051381:Rats; D012428:Ruthenium / Q000494:pharmacology
D002951:Citrates; D010728:Phosphoenolpyruvate; D012428:Ruthenium; D000255:Adenosine Triphosphate; D010100:Oxygen; D002118:Calcium