Linkage of the loci for glucose-6-phosphate dehydrogenase and for inosinic acid pyrophosphorylase to the X chromosome of the field-vole Microtus agrestis.
It has been proposed that there are strong selective pressures which have acted during the evolution of mammals to conserve the linkage of genes on the X chromosome. If so, loci that are known to be X-linked in one mammalian species should be X-linked in others. The loci for glucose-6-phosphate dehydrogenase (E.C. 1.1.1.49) and for inosinic acid pyrophosphorylase (E.C. 2.4.2.8) are known to be X-linked in a variety of mammals. The linkage of these loci to the X chromosome of the field-vole, Microtus agrestis, is indicated by the pattern of segregation of these loci in hybrid cells derived by fusion of mouse cells with vole lymphocytes.
D000630:Aminopterin; D000818:Animals; D001345:Autoradiography; D002459:Cell Fusion; D003470:Culture Media; D046508:Culture Techniques; D004586:Electrophoresis; D005260:Female; D005347:Fibroblasts; D005796:Genes; D008040:Genetic Linkage; D005954:Glucosephosphate Dehydrogenase / Q000096:biosynthesis* / Q000378:metabolism; D006822:Hybrid Cells; D007042:Hypoxanthines / Q000378:metabolism; D007291:Inosine Monophosphate; D007621:Karyotyping; D007739:L Cells; D008214:Lymphocytes; D008297:Male; D051379:Mice; D010430:Pentosyltransferases / Q000096:biosynthesis* / Q000378:metabolism; D012377:Rodentia / Q000378:metabolism*; D012730:Sex Chromosomes; D013866:Thioguanine; D013936:Thymidine; D014316:Tritium
D003470:Culture Media; D007042:Hypoxanthines; D014316:Tritium; D007291:Inosine Monophosphate; D005954:Glucosephosphate Dehydrogenase; D010430:Pentosyltransferases; D013866:Thioguanine; D000630:Aminopterin; D013936:Thymidine