Alteration of L cell growth by antibody-stimulated incorporation of radioactive nucleosides.
Radioactive nucleoside incorporation into mouse L cells was stimulated by exposure of the cells to rabbit anti-L cell antibody. Use of nucleosides of high specific radioactivity permitted a selective reduction of replication of antibody-treated cells as compared to control cells. The mechanism most likely involves radioactive damage of nuclear contents and DNA.
D000818:Animals; D000906:Antibodies; D046508:Culture Techniques; D007457:Iodine Radioisotopes; D007739:L Cells / Q000187:drug effects / Q000276:immunology / Q000378:metabolism*; D051379:Mice; D009705:Nucleosides / Q000378:metabolism*; D011817:Rabbits / Q000276:immunology; D013268:Stimulation, Chemical
D000906:Antibodies; D007457:Iodine Radioisotopes; D009705:Nucleosides