Ocular effects of oral contraceptives. I. Studies in the dog.
The administration of two oral contraceptives to female dogs for 5 years did not produce ocular lesions. Corneal and lenticular opacities occurred with equal frequency in control and treated groups, and fundic lesions, including papilledema, venous dilatation, and venous or arterial retinal thrombosis, were not produced by doses of Enovid-E or Ovulen 1, 10, and 25 times the human dose.
D000818:Animals; D001835:Body Weight / Q000187:drug effects; D002386:Cataract / Q000139:chemically induced; D003276:Contraceptives, Oral / Q000009:adverse effects*; D003277:Contraceptives, Oral, Combined / Q000009:adverse effects* / Q000494:pharmacology; D003318:Corneal Opacity / Q000139:chemically induced; D004285:Dogs; D005040:Ethynodiol Diacetate / Q000494:pharmacology; D005123:Eye / Q000187:drug effects*; D005128:Eye Diseases / Q000139:chemically induced*; D005260:Female; D005654:Fundus Oculi / Q000187:drug effects; D007908:Lens, Crystalline / Q000187:drug effects; D008656:Mestranol / Q000494:pharmacology; D009026:Mortality; D009641:Norethynodrel / Q000494:pharmacology; D010211:Papilledema / Q000139:chemically induced; D012171:Retinal Vessels; D013927:Thrombosis / Q000139:chemically induced
D003276:Contraceptives, Oral; D003277:Contraceptives, Oral, Combined; D005040:Ethynodiol Diacetate; D009641:Norethynodrel; D008656:Mestranol