Genetic control of chloroform toxicity in mice.
Mouse strain differences suggest intermediate or multifactorial gentic control of chloroform-induced renal toxicity and death. The chloroform dose lethal to 50 percent of animals was four times higher in C57BL/6J males than in DBA/2J males. Twice as much chloroform accumulated in the kidneys of the sensitive as the resistant strain. First generation offspring were midway between parental strains for both parameters.
D000728:Androgens / Q000502:physiology; D000818:Animals; D002725:Chloroform / Q000378:metabolism / Q000633:toxicity*; D004305:Dose-Response Relationship, Drug; D005796:Genes; D006579:Heterozygote; D007668:Kidney / Q000187:drug effects / Q000378:metabolism / Q000473:pathology; D007928:Lethal Dose 50; D008099:Liver / Q000187:drug effects / Q000378:metabolism / Q000473:pathology; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL / Q000378:metabolism*; D008811:Mice, Inbred DBA / Q000378:metabolism*
D000728:Androgens; D002725:Chloroform