Some pharmacological properties of 2-aryl-1,3-indandione derivatives.
Some pharmacological properties of indandione derivatives have been studied in laboratory animals. These substances possess anti-inflammatory, analgesic and anti-coagulent effects, as already known for other indandione derivatives. In addition they possess anti-tussive effects in mice. Unfortunately many of these molecules have also ulcerogenic effects. This fact is disappointing for those indandione derivatives which already are in therapeutic use, as G/18 (Uridion¿) and Emandione¿. It appears that compounds which have two Br in R1 and R4 position possess at the same time low toxicity and no ulcerogenic effects in addition to anti-inflammatory (G/21) and also anti-coagulant (G/22) interesting activity.
D000700:Analgesics / Q000494:pharmacology; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use; D000925:Anticoagulants / Q000494:pharmacology; D000996:Antitussive Agents / Q000494:pharmacology; D004353:Drug Evaluation, Preclinical; D004487:Edema / Q000188:drug therapy; D005260:Female; D006099:Granuloma / Q000188:drug therapy; D007189:Indans / Q000494:pharmacology* / Q000627:therapeutic use / Q000633:toxicity; D007192:Indenes / Q000494:pharmacology*; D007213:Indomethacin / Q000494:pharmacology; D007928:Lethal Dose 50; D008297:Male; D051379:Mice; D010653:Phenylbutazone / Q000494:pharmacology; D051381:Rats; D013276:Stomach Ulcer / Q000139:chemically induced; D013329:Structure-Activity Relationship
D000700:Analgesics; D000893:Anti-Inflammatory Agents; D000925:Anticoagulants; D000996:Antitussive Agents; D007189:Indans; D007192:Indenes; D010653:Phenylbutazone; D007213:Indomethacin