Acetazolamide, metabolic acidosis, and intraocular pressure.
In order to investigate whether or not there is a causal relationship between the metabolic acidosis and the ocular hypotension induced by acetazolamide, we undertook to correlate over a period of time the blood-acidifying and ocular-hypotonizing effects of administering the lowest intravenous effective dose of acetazolamide; to treat the metabolic acidosis induced by acetazolamide by means of the intravenous introduction of bases, and pulmonary hyperventilation (respiratory alkalosis); to evaluate the effects on the intraocular pressure (IOP) by neutralizing the acetazolamide-induced metabolic acidosis by means of a continuous infusion of sodium bicarbonate; to determine the relationship between the metabolic acidosis induced by blood-acidifying agents, which do not inhibit carbonic anhydrase, and the IOP; and to determine the changes in the acid-base status of the aqueous humor induced by acetazolamide and other blood-acidifying drugs. We found that the hypertonic buffering solution of sodium bicarbonate could reduce the IOP by itself through an osmotic mechanism. On the basis of our results, we believe that a causal relationship exists between the metabolic acidosis induced by acetazolamide, and by other drugs that have a blood-acidifying effect as the result of other mechanisms, and ocular hypotension, bothin the animal and in the glaucomatous patient.
D000086:Acetazolamide / Q000494:pharmacology*; D000136:Acid-Base Equilibrium / Q000187:drug effects; D000138:Acidosis / Q000139:chemically induced / Q000150:complications* / Q000628:therapy; D000472:Alkalosis, Respiratory; D000818:Animals; D001205:Ascorbic Acid / Q000494:pharmacology; D002021:Buffers; D002122:Calcium Chloride / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D005901:Glaucoma / Q000097:blood / Q000378:metabolism*; D006801:Humans; D006852:Hydrochlorothiazide / Q000494:pharmacology; D007429:Intraocular Pressure / Q000187:drug effects*; D009994:Osmolar Concentration; D011817:Rabbits
D002021:Buffers; D006852:Hydrochlorothiazide; D002122:Calcium Chloride; D000086:Acetazolamide; D001205:Ascorbic Acid