Progressive multifocal leukoencephalopathy: a complication of immunosuppressive treatment.
Progressive multifocal leukoencephalopathy developed in a patient with rheumatoid arthritis after treatment with an immunosuppressive agent (chlorambucil). We fell that this case lends further support to the concept that an altered immunologic state is important in the appearance of this infection, which is probably viral in origin.
D001172:Arthritis, Rheumatoid / Q000188:drug therapy; D001996:Bronchopneumonia / Q000150:complications; D002540:Cerebral Cortex / Q000473:pathology; D002699:Chlorambucil / Q000009:adverse effects*; D006046:Gold / Q000627:therapeutic use; D006801:Humans; D007166:Immunosuppressive Agents / Q000009:adverse effects*; D007968:Leukoencephalopathy, Progressive Multifocal / Q000209:etiology* / Q000382:microbiology / Q000473:pathology; D008297:Male; D008875:Middle Aged; D009503:Neutropenia / Q000139:chemically induced; D009836:Oligodendroglia / Q000382:microbiology / Q000473:pathology; D027383:Papillomaviridae / Q000302:isolation & purification; D027382:Polyomaviridae; D011241:Prednisone / Q000627:therapeutic use
D007166:Immunosuppressive Agents; D002699:Chlorambucil; D006046:Gold; D011241:Prednisone