[Kidney lesion in mice from an antirenal serum].
Intravenous administration of anti-renal serum in a dose 1--1.6 ml to mice line CBA brought about drastic changes in the kidney ranging from severe dystrophy of the tubule cells to necrosis of the epithelium of the proximal and straight tubules. A smaller dose (0.5 ml) produced initially degenerative changes in individual cells of the proximal convoluted and straight tubules, and 2--6 months later degenerative changes were noted almost in all cells of the tubules referred to above. The glomerular apparatus was affected in a lesser degree. The relative weight of the kidneys of the mice treated with anti-renal serum at the end of the 3rd month was less than that in control animals. The urine contained granular and hyaline cylinders and a considerable amount of protein. Concentration of urea in the blood serum of the experimental animals was found to be elevated.
D000818:Animals; D000941:Antigens / Q000008:administration & dosage; D004305:Dose-Response Relationship, Drug; D005260:Female; D007106:Immune Sera / Q000494:pharmacology*; D007668:Kidney / Q000276:immunology* / Q000473:pathology; D007674:Kidney Diseases / Q000139:chemically induced* / Q000473:pathology; D007678:Kidney Glomerulus / Q000473:pathology; D007687:Kidney Tubules, Proximal / Q000473:pathology; D051379:Mice; D008808:Mice, Inbred CBA; D011247:Pregnancy; D011507:Proteinuria / Q000652:urine; D011817:Rabbits; D013997:Time Factors; D014508:Urea / Q000097:blood; D014556:Urine / Q000166:cytology
D000941:Antigens; D007106:Immune Sera; D014508:Urea
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