Polymorphonuclear leukocytes in antibody-dependent cellular cytotoxicity.
Human polymorphonuclear leukocytes (PMN) lyse antibody-coated target cells in an immunologically specific fashion--antibody-dependent cellular cytotoxicity (ADCC). PMN-mediated cytolysis is independent of complement, de novo protein synthesis, and DNA replication. Cytolysis is rapid, detectable at low PMN:target cell ratios, and exceeds lymphocyte-mediated ADCC. The interaction appears to be mediated via an Fc receptor and is inhibited by aggregated gamma-globulin. A role for PMN in host tumor cell immunity is discussed.
D000042:Absorption; D000818:Animals; D000918:Antibody Specificity; D002351:Carrageenan / Q000494:pharmacology; D002469:Cell Separation; D002701:Chloramphenicol / Q000494:pharmacology; D002860:Chromium Radioisotopes; D003513:Cycloheximide / Q000494:pharmacology; D003601:Cytotoxicity Tests, Immunologic; D006801:Humans; D007106:Immune Sera; D007111:Immunity, Cellular / Q000187:drug effects; D007942:Leukemia, Experimental / Q000276:immunology; D008214:Lymphocytes / Q000276:immunology; D009504:Neutrophils / Q000166:cytology / Q000276:immunology*; D011691:Puromycin / Q000494:pharmacology; D011817:Rabbits / Q000276:immunology; D051381:Rats / Q000276:immunology
D002860:Chromium Radioisotopes; D007106:Immune Sera; D011691:Puromycin; D002701:Chloramphenicol; D002351:Carrageenan; D003513:Cycloheximide