5-Decynedioic acid, an acetylenic compound in human urine.
An acetylenic dicarboxylic acid, 5-decynedioic acid, has been isolated from human urine. The structure was determined by mass spectrometry of several derivatives, and by infrared spectroscopy. On osmium tetroxide oxidation, a vic-diketone was formed, the mass spectrum of which established the position of the triple bond between carbon atoms 5 and 6. Mass spectrometric evidence for the presence of a small amount of the isomeric 4-decynedioic acid was also obtained. The 24-h excretion of these acids is 0.01-0.1 mmol for healthy adults on a regular diet.
D000328:Adult; D000480:Alkynes / Q000302:isolation & purification / Q000652:urine*; D003998:Dicarboxylic Acids / Q000302:isolation & purification / Q000652:urine; D005231:Fatty Acids, Unsaturated / Q000302:isolation & purification / Q000652:urine*; D006801:Humans; D013058:Mass Spectrometry; D013055:Spectrophotometry, Infrared; D014297:Trimethylsilyl Compounds
D000480:Alkynes; D003998:Dicarboxylic Acids; D005231:Fatty Acids, Unsaturated; D014297:Trimethylsilyl Compounds; C011432:5-decynedioic acid