Relationship of steroid structure to induction of chymotrypsinogen in embryonic chick pancreas in vitro.
The effect of steroid structure on induction of chymotrypsinogen in embryonic chick pancreas was examined in vitro. In order of decreasing potency cortisol, corticosterone, and 21-deoxycortisol are classified as optimal inducers, whereas 11beta-hydroxyprogesterone, 11-deoxycortisol, cortisone, 11-deoxycorticosterone and 17-alpha-hydroxyprogesterone are classified as suboptimal inducers. Progesterone was inactive. It is concluded that the relative importance of the steroid hydroxyl groups for activity is 11beta greater than 21 greater than 17 alpha, and that their effect is cumulative.
D000305:Adrenal Cortex Hormones / Q000494:pharmacology*; D000818:Animals; D002642:Chick Embryo; D002919:Chymotrypsinogen / Q000096:biosynthesis*; D003345:Corticosterone / Q000494:pharmacology; D003348:Cortisone / Q000494:pharmacology; D003350:Cortodoxone / Q000494:pharmacology; D003900:Desoxycorticosterone / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D004790:Enzyme Induction / Q000187:drug effects; D006854:Hydrocortisone / Q000494:pharmacology; D010179:Pancreas / Q000187:drug effects / Q000201:enzymology*; D013329:Structure-Activity Relationship; D013997:Time Factors
D000305:Adrenal Cortex Hormones; D003900:Desoxycorticosterone; D002919:Chymotrypsinogen; D003348:Cortisone; D003345:Corticosterone; D003350:Cortodoxone; D006854:Hydrocortisone