A comparative cytological study between hepatocytes of insecticide-resistant and susceptible mosquitofish (Gambusia affinis).
The livers from a naturally occurring insecticide-resistant mosquitofish population were examined cytologically and compared to liver preparations from a susceptible population. There was a marked increase in cell size and lipid inclusions in the hepatocytes of resistant mosquitofish as compared to susceptible mosquitofish. The pronounced lipid inclusions in the liver preparations of resistant mosquitofish remained essentially unchanged in mosquitofish starved for up to 2 weeks. No observable differences were noted in any cellular organelles.
D000818:Animals; D003532:Cyprinodontiformes; D004351:Drug Resistance; D006843:Hydrocarbons, Chlorinated; D007306:Insecticides / Q000494:pharmacology*; D008055:Lipids / Q000032:analysis; D008099:Liver / Q000166:cytology / Q000187:drug effects* / Q000648:ultrastructure; D008854:Microscopy, Electron; D013347:Subcellular Fractions / Q000648:ultrastructure; D013997:Time Factors
D006843:Hydrocarbons, Chlorinated; D007306:Insecticides; D008055:Lipids