Synthesis and pharmacological properties of new pyridine derivatives.2,6-bis-[diphenyl-(and dibenzyl)-hydroxymethyl]-piperidines.
Syntheses of 2,6-bis-(diphenylhydroxymethyl)-, 2,6-bis-(dibenzylhydroxymethyl)- and 2,6-bis-(phenylbenzylhydroxymethyl)-pyridines were carried out. These compound were hydrogenated to the corresponding piperidine carbinols. The compounds are of low toxicity and were tested on mice for their CNS activity, using climbing test. 2,6-bis-(dibenzylhydroxymethyl)-piperidine (VI) exhibited central depressive activity.
D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects; D002490:Central Nervous System / Q000187:drug effects; D055598:Chemical Phenomena; D002621:Chemistry; D007928:Lethal Dose 50; D051379:Mice; D008970:Molecular Weight; D010880:Piperidines / Q000138:chemical synthesis / Q000494:pharmacology* / Q000633:toxicity; D012890:Sleep / Q000187:drug effects
D010880:Piperidines