Albinism and auditory function in the laboratory mouse. II. Effects of acoustic priming and cross-fostering.
Albino (c/c) and nonalbino (+/c and +/+) congenic C57BL/6J mice were examined for the effects of acoustic prestimulation (priming) on audiogenic seizures. While no genotypic-specific effects were noticed 1 day after priming, major effects were observed in separate groups of mice tested 5 days after priming. The c/c mice were most susceptible to audiogenic seizures, and no differences were observed between +/c and +/+ mice. While cross-fostering did not change this relationship, it provided protection from acoustic trauma is considered inconclusive because of the interaction of innate- and priming-induced audiogenic seizures in the +/c and c/c mice.
D000367:Age Factors; D000417:Albinism / Q000235:genetics / Q000503:physiopathology*; D000818:Animals; D001307:Auditory Perception / Q000502:physiology*; D001835:Body Weight; D005838:Genotype; D051379:Mice; D008810:Mice, Inbred C57BL; D012640:Seizures / Q000209:etiology* / Q000517:prevention & control; D013016:Sound / Q000009:adverse effects