Effect of bretylium on cardiovascular changes induced by coronary occlusion in the cat.
The influence of bretylium pretreatment on the heart rate, blood pressure, contractile force and cardiac rhythm changes produced by occlusion of the anterior descending coronary artery was evaluated in chloralose-anesthetized cats. Bretylium pretreatment shortened the duration of the ventricular arrhythmia. This drug however had no effect on the other cardiovascular changes evoked by coronary occlusion. These results suggest that the sympathetic nervous system has a role in maintaining electrical instability after experimentally induced myocardial infarction.
D000818:Animals; D001145:Arrhythmias, Cardiac / Q000139:chemically induced; D001794:Blood Pressure / Q000187:drug effects; D001949:Bretylium Compounds / Q000494:pharmacology*; D002415:Cats; D003331:Coronary Vessels / Q000502:physiology*; D006339:Heart Rate / Q000187:drug effects; D006439:Hemodynamics / Q000187:drug effects*; D008026:Ligation; D009200:Myocardial Contraction / Q000187:drug effects; D013564:Sympathetic Nervous System / Q000502:physiology
D001949:Bretylium Compounds