[Effect of psychotropic substances on the uptake of [H3]-gamma-aminobutyric acid by rat brain synaptosomes].
The in vitro effects of some neuroleptics and antidepressants on the accumulation of [3H]/-GABA by the synaprosomes of the rat brain cortex were studied. Chloropromazine, trifluoperazine, fluphenazine, perphenazine, thioproperazine, haloperidol, trifluperidol,  droperidol, imipramine, haloanison and phthoracyzine were found (in order of a decreasing activity) to inhibit the [3H]/-GABA uptake of synaptosomes. Neuroleptics, except for a new drug carbidine, proved to be more potent inhibitors than antidepressants are. The tranquilized diazepan failed to have any effect on the [3H]/-GABA uptake. The rats synaptosomes treated with chlorpromazine and imipramine were found to display a decreased ability to accumulate [3H]/-GABA. The suppressive effect of psychotropic agents on the [3H]/-GABA uptake by synaptosomes is suggested to be due, at least partly, to their known inhibitory influence on the Na+, K+-dependent ATPase.
D000613:Aminobutyrates / Q000378:metabolism*; D000818:Animals; D000928:Antidepressive Agents / Q000494:pharmacology; D001921:Brain / Q000187:drug effects* / Q000378:metabolism; D003864:Depression, Chemical; D066298:In Vitro Techniques; D008297:Male; D011619:Psychotropic Drugs / Q000494:pharmacology*; D051381:Rats; D013574:Synaptosomes / Q000187:drug effects* / Q000378:metabolism; D014149:Tranquilizing Agents / Q000494:pharmacology; D014316:Tritium
D000613:Aminobutyrates; D000928:Antidepressive Agents; D011619:Psychotropic Drugs; D014149:Tranquilizing Agents; D014316:Tritium
Vliianie psikhotropnykh veshchestv na zakhvat [H3]-gamma-aminomaslianoĭ kisloty sinaptosomami mozga krys