[Changes in the liver lysosomes of the rat in chronic toxic hepatitis].
A study was made of permeability of the lysosome membranes and subcellular distribution of acid hydrolases in chronic hepatitis caused by CCl4 inhalation and during the restoration of the liver after injury. No normalization of the indices under study occurred during the period of up to 14 days after the last CCl4 inhalation: changes in the stability of the lysosome membran persisted and redistribution of acid hydrolases was noted. This redistribution was associated with both the processes of injury and restoration of the liver.
D000135:Acid Phosphatase / Q000378:metabolism; D000818:Animals; D002252:Carbon Tetrachloride Poisoning / Q000503:physiopathology; D002462:Cell Membrane / Q000187:drug effects; D056486:Chemical and Drug Induced Liver Injury / Q000503:physiopathology*; D002908:Chronic Disease; D004781:Environmental Exposure; D008099:Liver / Q000166:cytology* / Q000187:drug effects; D008115:Liver Regeneration / Q000187:drug effects; D008247:Lysosomes / Q000187:drug effects* / Q000378:metabolism; D008297:Male; D011506:Proteins / Q000378:metabolism; D051381:Rats; D012260:Ribonucleases / Q000378:metabolism; D013347:Subcellular Fractions / Q000378:metabolism; D013997:Time Factors
D011506:Proteins; D012260:Ribonucleases; D000135:Acid Phosphatase
Izmeneniia lizosom pecheni krys pri khronicheskom toksicheskom gepatite