[Spontaneous chromosome aberrations in the oogenesis of laboratory rats].
Cytological preparations were made by Tarkovsky's method from 2335 rat oocytes obtained after an induced superodulation. The chromosomes could be counted exactly in 861 oocytes. In 797 oocytes (92.7%) euploidy (metaphase II with 21 chromosomes) and in 64 oocytes (7.5%) aneuploidy was found. 60 oocytes were hypoploid, but only 4 oocytes (0.4%) were hyperploid (with 22 chromosomes). Hypoploidy can often be due to the presence of artefacts. Probably the rate of spontaneous aneuploidy in rat oogenesis is about 0.8%, this being significantly lower than the rate of spontaneous aneuploidy in mice oogenesis.
D000782:Aneuploidy; D000818:Animals; D000830:Animals, Laboratory; D006063:Chorionic Gonadotropin / Q000008:administration & dosage; D002869:Chromosome Aberrations; D005260:Female; D006062:Gonadotropins / Q000008:administration & dosage; D007621:Karyotyping; D008540:Meiosis; D008938:Mitosis; D009865:Oocytes / Q000648:ultrastructure; D009866:Oogenesis; D010060:Ovulation / Q000187:drug effects; D011003:Ploidies; D051381:Rats; D013997:Time Factors
D006063:Chorionic Gonadotropin; D006062:Gonadotropins
O sopntannykh khromosomnykh aberratsiiakh v oogeneze laboratornykh krys