The effect of glycerol on the lacrate metabolism in the perfused tat liver.
The effect of glycerol on the lactate metabolism was studied on the perfused rat liver. Addition of glycerol to the perfusion medium caused a significant output of lactate and uptake of pyruvate. The lactate/pyruvate- and beta-hydroxybutyrate/acetoacetate ratios rose indicating an effect of glycerol on the cytoplasmic and mitochondrial redox potentials which became more reduced. The output of lactate by the liver may be a result of the reduction in the redox level induced by the oxidation of glycerol.
D000818:Animals; D005990:Glycerol / Q000494:pharmacology; D007773:Lactates / Q000378:metabolism; D008099:Liver / Q000187:drug effects / Q000378:metabolism; D008297:Male; D010084:Oxidation-Reduction; D010101:Oxygen Consumption / Q000187:drug effects; D011773:Pyruvates / Q000378:metabolism; D051381:Rats; D013997:Time Factors
D007773:Lactates; D011773:Pyruvates; D005990:Glycerol