The effects on liver metabolism of administering excesses of biotin to immature pullets and laying hens.
1. The administration of a ten-fold excess of biotin to immature chicks and a 25-fold excess to laying hens had no adverse effect on growth rate, liver weight or liver lipid content. 2. There were no marked effects of excess biotin on glutamate-metabolising enzymes but the specific activity of ATP citrate lyase was decreased.
D001275:ATP Citrate (pro-S)-Lyase / Q000378:metabolism; D000818:Animals; D001710:Biotin / Q000494:pharmacology*; D002645:Chickens / Q000378:metabolism* / Q000502:physiology; D005260:Female; D008099:Liver / Q000187:drug effects / Q000378:metabolism*; D010058:Oviposition
D001710:Biotin; D001275:ATP Citrate (pro-S)-Lyase