Relationships between the biological and physicochemical properties of series of compounds.
An equilibrium model is described for relationships between the biological activity and the physicochemical properties of compounds in a congeneric series. An equation derived from the model is of the form, log C = log (a + 10-alpha) = b, where C is the total molar concentration of drug to produce a standard response, alpha ia a parameter of the form log K where K is an equilibrium constant, and a and b are coefficients. This equation provides a plausible fit to some nonlinear observations which have been studied.
D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents / Q000494:pharmacology; D001419:Bacteria / Q000187:drug effects; D007700:Kinetics; D003904:Mitosporic Fungi / Q000187:drug effects; D008956:Models, Chemical; D009994:Osmolar Concentration; D012044:Regression Analysis; D013329:Structure-Activity Relationship
D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents