Metastatic adrenal cortical carcinoma. Documented cure with combined chemotherapy.
In 1966, we published the case report of a patient with adrenal carcinoma and wide spread metatasis who, after treatment with mitotane (o,p-DDD) and fluorouracil, developed Addison disease accompanied by a clinical remission. The patient's unexpected death from an unrelated cause now allows us to verify what to our knowledge is the first cure of metastatic adrenal carcinoma by chemotherapy.
D000293:Adolescent; D000310:Adrenal Gland Neoplasms / Q000188:drug therapy*; D002277:Carcinoma / Q000188:drug therapy*; D004359:Drug Therapy, Combination; D005260:Female; D005472:Fluorouracil / Q000627:therapeutic use*; D006801:Humans; D008939:Mitotane / Q000627:therapeutic use*; D009362:Neoplasm Metastasis / Q000188:drug therapy
D008939:Mitotane; D005472:Fluorouracil