[Morphological aspects concerning a hepatogenic conception of hyperbilirubinemia (author's transl)].
Liver biopsies of 2825 patients with various acute and chronic diseases of liver, gall bladder or pancreas were studied by means of modern techniques of the functional morphology (histochemistry-enzyme histochemistry, electron microscopy). Different icteric forms (prehepatic, hepatic and posthepatic icterus) are associated with distinct structural and functional changes of the hepatocytes and the intrahepatic bile ducts accompanied by a complex of disturbances in the bilirubin metabolism. In the early stage of icterus we found distinct pathogenetic and morphological differences between different forms of icterus. Following secondary alterations of the liver tissue these differences are lost. All steps of the bilirubin metabolism are disturbed now.
D000437:Alcoholism / Q000503:physiopathology; D000745:Anemia, Hemolytic, Congenital / Q000503:physiopathology*; D001653:Bile Ducts, Intrahepatic / Q000503:physiopathology; D056486:Chemical and Drug Induced Liver Injury / Q000503:physiopathology; D002908:Chronic Disease; D005234:Fatty Liver / Q000503:physiopathology; D006505:Hepatitis / Q000503:physiopathology; D006506:Hepatitis A / Q000503:physiopathology; D006651:Histocytochemistry; D006801:Humans; D006932:Hyperbilirubinemia / Q000503:physiopathology*; D006933:Hyperbilirubinemia, Hereditary / Q000503:physiopathology; D007565:Jaundice / Q000473:pathology; D008099:Liver / Q000503:physiopathology; D008103:Liver Cirrhosis / Q000503:physiopathology
Morphologische Aspekte einer hepatogenen Konzeption der Hyperbilirubinämie