[Effect of naftidrofuryl on creatinine serum concentration and on PAH/inulin clearance in peripheral arterial occlusive diseases].
The effect of 200 mg 3-(1-naphthyl)-2-tetrahydrofurfurylpropionic acid beta-diethylaminoethylester (naftidrofuryl, Dusodril) administered as a single i.v. infusion, on serum creatinine was investigated in 10 patients with occlusive disease of the peripheral arteries (average age 58.6 years). In a second group of similar patients (average age 60.5 years) determinations of PAH/inulin clearance and serum creatinine were performed prior to and immediately after treatment with 400 mg naftidrofuryl per day over a period of two weeks. Creatinine concentration did not change following acute or chronic administration of naftidrofuryl; glomerular filtration rate and renal plasma flow were not affected by prolonged treatment (2 alpha less than 0.05). An obligatorily nephrotoxic effect of naftidrofuryl can therefore be ruled out.
D000618:Aminohippuric Acids / Q000652:urine*; D001157:Arterial Occlusive Diseases / Q000188:drug therapy / Q000503:physiopathology*; D003404:Creatinine / Q000097:blood*; D005663:Furans / Q000494:pharmacology*; D005919:Glomerular Filtration Rate / Q000187:drug effects*; D006801:Humans; D007275:Injections, Intravenous; D007444:Inulin / Q000652:urine*; D007668:Kidney / Q000098:blood supply; D008875:Middle Aged; D009257:Nafronyl / Q000494:pharmacology* / Q000627:therapeutic use; D012039:Regional Blood Flow / Q000187:drug effects; D013997:Time Factors
D000618:Aminohippuric Acids; D005663:Furans; D009257:Nafronyl; D007444:Inulin; D003404:Creatinine
Untersuchunger uber den Einfluss von Naftidrofuryl auf die Kreatinin-Konzentration im Serum und die PAH/Inulin-Clearance bei peripher arteriellen Durchblutungsstörungen