[Cholinoreception of chick embryo myocardial explants].
The effects of acetylcholine, subecholine (selective nicotinomimetic) and methylfurmetide (selective muscarinomimetic) on the spontaneous contractions of atrial and ventricular explants from the heart of 408 day embryos as well as of mixed explants, have been studied by means of a special photoelectric device. In most of the experiments, acetylcholine reduced the rate of contractions, the sensitivity of preparations being increased with the age of embryos. Preliminary atropine treatment reversed or significantly decreased acetylcholine effect. Subecholine usually increased the contraction rhythm, whereas methylfurmetide decreased the spontaneous activity.
D000109:Acetylcholine / Q000494:pharmacology*; D000818:Animals; D001285:Atropine / Q000494:pharmacology; D002642:Chick Embryo; D002794:Choline / Q000031:analogs & derivatives / Q000494:pharmacology; D046508:Culture Techniques; D003864:Depression, Chemical; D003998:Dicarboxylic Acids / Q000494:pharmacology; D005731:Ganglionic Stimulants / Q000494:pharmacology; D006339:Heart Rate / Q000187:drug effects*; D009206:Myocardium / Q000201:enzymology*; D010277:Parasympathomimetics / Q000494:pharmacology; D000644:Quaternary Ammonium Compounds / Q000031:analogs & derivatives / Q000494:pharmacology; D013268:Stimulation, Chemical
D003998:Dicarboxylic Acids; D005731:Ganglionic Stimulants; D010277:Parasympathomimetics; D000644:Quaternary Ammonium Compounds; D001285:Atropine; D002794:Choline; D000109:Acetylcholine
Izuchenie kholinoretseptsii éksplantatov miokarda kurinogo émbriona