[Determination of the nucleolar coefficient in lymphocytes in chemotherapeutically treated patients with ovarian carcinoma].
At the total evaluation of the base values of lymphocytes in the patients with Ca ovariorum a lower number of lymphocytes was found than in the healthy population. At the same time the lymphocytes in the patients with Ca contained a lower number of nucleoli which are capable of the synthesis RNA (i.e. nucleoli ringsingers and active) and a higher number of nucleoli irreversible unable of the synthesis of RNA, i.c. micronucleoli. So the value of the nucleolar coefficient was rised, too, in these patients. It seems, that the described changes were dependent of the clinic condition of our patients, in some cases they preceded the state. This method is utilised at the IInd Obstetric Gynaec. Clin. in Prague for the long time cytostatic therapy.
D000179:Acrylates / Q000627:therapeutic use; D000840:Anisoles / Q000627:therapeutic use; D001966:Bromine / Q000627:therapeutic use; D002466:Cell Nucleolus; D003520:Cyclophosphamide / Q000627:therapeutic use; D005260:Female; D006801:Humans; D007659:Ketones / Q000627:therapeutic use; D008214:Lymphocytes / Q000473:pathology*; D010051:Ovarian Neoplasms / Q000188:drug therapy / Q000473:pathology*; D012313:RNA / Q000096:biosynthesis
D000179:Acrylates; D000840:Anisoles; D007659:Ketones; D012313:RNA; D003520:Cyclophosphamide; D001966:Bromine
Bestimmung des Nukleolarkoeffizienten in den Lymphozyten bei chemotherapeutisch behandelten Patientinnen mit Ovarialkarzinom