Uptake and release of 3H-metaraminol by rat lung. The influence of various drugs.
Uptake and release of 3H-metaraminol was measured in vitro incubating rat lung tissue in the presence of ouabain (1.5-45 mug/ml), cocaine (1-30 mug/ml), tyramine (0.1-3 mug/ml, reserpine (0.05-1.5 mug/ml), imipramine (0.1-3 mug/ml) and desipramine (0.3-10 mug/ml. All drugs significantly inhibited uptake and release of 3H-metaraminol from lung tissue. This blockade most probably occurs at membrane levels of both neuronal uptake-1 sites and extraneuronal uptake-2 sites. These results further emphasize the importance of the lung in the fate of drugs and endogenous substances.
D000818:Animals; D003042:Cocaine / Q000494:pharmacology; D003891:Desipramine / Q000494:pharmacology; D005260:Female; D007099:Imipramine / Q000494:pharmacology; D066298:In Vitro Techniques; D008168:Lung / Q000187:drug effects / Q000378:metabolism*; D008680:Metaraminol / Q000378:metabolism*; D010042:Ouabain / Q000494:pharmacology; D051381:Rats; D012110:Reserpine / Q000494:pharmacology; D013997:Time Factors; D014439:Tyramine / Q000494:pharmacology
D010042:Ouabain; D008680:Metaraminol; D012110:Reserpine; D003042:Cocaine; D007099:Imipramine; D003891:Desipramine; D014439:Tyramine