The interaction of post-weaning housing conditions and prenatal drug effects on behaviour.
Offspring of rats given oral doses of imipramine (5 mg/kg) from 14-2f gestation were reared, after weaning, in deprived or enriched environments. When tested in both a Henderson-type maze and a swimming maze no behavioural effects due to prenatal drug exposure were observed when the Ss were reared in a deprived environment. When the Ss were reared in an enriched environment the maze performance of those animals which had been exposed to imipramine or vitamin-A was significantly inferior to that of the control animals. The implications of these findings are discussed with respect to environmental interaction with prenatal drug effects on behavior.
D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects*; D005260:Female; D005333:Fetus / Q000187:drug effects*; D005865:Gestational Age; D007099:Imipramine / Q000494:pharmacology*; D007858:Learning / Q000187:drug effects; D009048:Motor Skills / Q000187:drug effects; D011247:Pregnancy; D011610:Psychosocial Deprivation; D051381:Rats; D012153:Retention, Psychology / Q000187:drug effects; D012931:Social Environment; D014801:Vitamin A / Q000494:pharmacology*
D014801:Vitamin A; D007099:Imipramine