Biopharmaceutic influences on the anticholinergic effects of propantheline.
With reduction of salivary flow rates as an index of anticholinergic response, 3 subjects manifested demonstrable effects shortly after ingestion of 15-mg doses of propantheline in conventional tablets. Ingestion of this dose i-mediately after a standardized breakfast substantially reduced the anticholinergic effects. In 1 subject, a dose-response relationship was noted after 15 mg and 30 mg doses under both fasting and fed conditions, but at each dose level the influence of food was clear. Administration of a 30-mg dose of propantheline in a commercially available "prolonged-acting" tablet induced little if any anticholinergic effects; in 2 subjects, marginal but fleeting indications of salivary suppression were noted about 4 hr after ingestion, while no effects were observed in the third subject (even after 2 "prolonged-acting" tablets).
D000328:Adult; D001702:Biopharmaceutics; D003692:Delayed-Action Preparations; D003864:Depression, Chemical; D005260:Female; D006801:Humans; D008297:Male; D010276:Parasympatholytics / Q000494:pharmacology*; D011413:Propantheline / Q000008:administration & dosage / Q000494:pharmacology*; D012472:Salivation / Q000187:drug effects; D013997:Time Factors
D003692:Delayed-Action Preparations; D010276:Parasympatholytics; D011413:Propantheline