Diarrhoeae in thyroid medullary carcinoma: role of prostaglandins and therapeutic effect of nutmeg.
In a patient with medullary carcinoma of the thyroid with pulmonary metastases who presented with diarrhoea and steatorrhoea large amounts of prostaglandin-like material were present in peripheral blood, and some was extracted from the tumour. The diarrhoea which persisted after thyroidectomy responded to treatment with nutmeg.
D000328:Adult; D002277:Carcinoma / Q000097:blood / Q000150:complications* / Q000473:pathology; D002338:Carotenoids / Q000097:blood; D002446:Celiac Disease / Q000517:prevention & control; D003061:Codeine / Q000627:therapeutic use; D003212:Condiments / Q000627:therapeutic use*; D003967:Diarrhea / Q000188:drug therapy / Q000209:etiology*; D004157:Diphenoxylate / Q000627:therapeutic use; D005260:Female; D006213:Hallucinogens / Q000627:therapeutic use*; D006801:Humans; D008175:Lung Neoplasms; D009362:Neoplasm Metastasis; D011453:Prostaglandins / Q000097:blood*; D011620:Psyllium / Q000627:therapeutic use; D013964:Thyroid Neoplasms / Q000097:blood / Q000150:complications* / Q000473:pathology; D013965:Thyroidectomy
D006213:Hallucinogens; D011453:Prostaglandins; D002338:Carotenoids; D004157:Diphenoxylate; D011620:Psyllium; D003061:Codeine