[In vitro biosynthesis of iodothyronines from diiodo-3,5-L-tyrosyl-diiodo-3,5-L-tyrosine (author's transl)].
A comparative study of two types of in vitro synthesis of iodothyronines has been done from 3,5-diiodotyrosine and from diiodo-3,5-L-tyrosyl-diiodo-3,5-L-tyrosine (Tyr(I)2-Tyr(I)2) (equimolecular in tyrosyl rings). Incubations are made with rat thyroid gland minces in Eagle's medium or with thyroid microsomal fraction. Synthesis of thyroid hormones from Tyr(I)2-Tyr(I)2 is faster and more important than from diiodo-3,5-L-tyrosine (Tyr(I)2). A mechanism of iodothyronine formation via Tyr(I)2-Tyr(I)2 and different from the one occuring for Tyr(I)2 is suggested.
D000818:Animals; D002417:Cattle; D004151:Dipeptides / Q000378:metabolism*; D007700:Kinetics; D008297:Male; D008861:Microsomes / Q000378:metabolism; D007470:Monoiodotyrosine / Q000031:analogs & derivatives / Q000378:metabolism*; D051381:Rats; D013961:Thyroid Gland / Q000378:metabolism*; D013974:Thyroxine / Q000096:biosynthesis*; D014284:Triiodothyronine / Q000096:biosynthesis*
D004151:Dipeptides; D014284:Triiodothyronine; D007470:Monoiodotyrosine; D013974:Thyroxine
Biosynthèse in vitro d'iodothyronines à partir du diiodo-3,5-L-tyrosyl-diiodo-3,5-L-tyrosine