[Effects of drugs on cell culture (I)].
Effects of drugs were studied on L-cell line: L, of mouse subcutaneous tissue origin. Results are as follows: the concentrations of 62.50 approximately 500 mug/ml for each drug were examined regarding inhibition of the growth of L-cell line. ID50 values of ibuprofen, naproxen, Y-5554, DICHLOFENAC AND AMINOPYRINE WERE FOUND TO BE 185, 185, 175, 145 AND GREATER THAN 500 MUG/ML RESPECTIVELY. Minimum concentration, caused by the detachment of the cell from the vessel wall, was as follows: ibuprofen 125 approximately 250, naproxen 250 approximately 500, Y-5554 125 approximately 250, dichlofenac 62.50 and aminopyrine 1,000 approximately 2,000 mug/ml respectively.
D000818:Animals; D002455:Cell Division / Q000187:drug effects; D004353:Drug Evaluation, Preclinical / Q000379:methods*; D007052:Ibuprofen / Q000494:pharmacology; D066298:In Vitro Techniques; D007739:L Cells / Q000187:drug effects*; D051379:Mice; D009288:Naproxen / Q000633:toxicity; D010648:Phenylacetates / Q000633:toxicity; D011409:Propylene Glycols / Q000633:toxicity; D014966:Xanthenes
D010648:Phenylacetates; D011409:Propylene Glycols; D014966:Xanthenes; D009288:Naproxen; D007052:Ibuprofen