The risk of atherosclerotic vascular disease in subjects with xanthomatosis.
The morbidity and mortality in 172 males and 164 females with xanthomatosis have been investigated. Symptoms of coronary heart disease (CHD) were the most frequent initial manifestation of atherosclerotic vascular disease. Angina pectoris was the first symptom in about 3/4 of males as well as females; myocardial infarction was the first event in 26% of the males and 9% of the females. Other manifestations of atherosclerosis were comparatively rare and occurred late in life. Half of the subjects were affected with symptoms of atherosclerotic vascular disease by the age of 52 in men and 62 in women, the mean age for first symptoms being 49 and 56 years, respectively. No significant influence of other CHD risk factors than xanthomatosis and hyperlipidaemia was found in these patients. An increase in the number of cardiovascular deaths was seen in xanthomatosis patients, compared with the general population, in particular in the number of "sudden deaths". Half of the males died before the age of 66 and half of the females before the age of 74.5, which is about 10 and 7 years earlier than predicted at 30 years of age for the normal population. The cumulative relative mortality in both men and women was about twice that expected for the general Norwegian population until 70 years of age.
D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000368:Aged; D000787:Angina Pectoris / Q000150:complications; D001161:Arteriosclerosis / Q000209:etiology*; D001794:Blood Pressure; D001827:Body Height; D001835:Body Weight; D002648:Child; D002784:Cholesterol / Q000097:blood; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000150:complications; D011379:Prognosis; D014280:Triglycerides / Q000097:blood; D014973:Xanthomatosis / Q000150:complications* / Q000401:mortality
D014280:Triglycerides; D002784:Cholesterol