General models for segregation analysis.
Theoretical details are given of various oligogenic models for segregation analysis that are available as a general segregation analysis ("GENSEG") package, programmed in FORTRAN iv. The models allow for up to two autosomal loci and one X-linked locus, normally distributed or dichotomous phenotypes, variable age of onset, and various ascertainment functions (including one that allows the probability of becoming a proband to be dependent on the age of onset). Current programs are limited to the analysis of 2-generational data, using the joint likelihood of the sibship and parental phenotypes, unless it can be assumed that the pedigrees being analyzed are a random sample from the population; half-sibships and twins, however, are explicitly allowed.
D000367:Age Factors; D002874:Chromosome Mapping; D002875:Chromosomes; D005260:Female; D005787:Gene Frequency; D030342:Genetic Diseases, Inborn; D006801:Humans; D008954:Models, Biological; D010375:Pedigree; D010641:Phenotype; D011247:Pregnancy; D012730:Sex Chromosomes; D012732:Sex Determination Analysis; D014427:Twins