Vitamin K requirement and warfarin tolerance in the hamster.
A dietary deficiency of vitamin K has been demonstrated in the Syrian hamster. This species has also been shown to be relatively resistant to the action of the indirect anticoagulant Warfarin, and very sensitive to the anticoagulant action of the vitamin K antagonist chloro-K. These observations, and the hamster's apparently high requirement for the vitamin, indicate that it responds to vitamin K and vitamin K antagonists in the same fashion as Warfarin-resistant strains of rats.
D000818:Animals; D000925:Anticoagulants / Q000494:pharmacology; D001777:Blood Coagulation / Q000187:drug effects; D006224:Cricetinae / Q000097:blood*; D004224:Diterpenes / Q000494:pharmacology; D004361:Drug Tolerance; D008297:Male; D009285:Naphthoquinones / Q000494:pharmacology; D011516:Prothrombin / Q000032:analysis; D013045:Species Specificity; D014812:Vitamin K / Q000037:antagonists & inhibitors; D010837:Vitamin K 1 / Q000031:analogs & derivatives; D014813:Vitamin K Deficiency / Q000097:blood*; D014859:Warfarin / Q000494:pharmacology*
D000925:Anticoagulants; D004224:Diterpenes; D009285:Naphthoquinones; D014812:Vitamin K; C002439:chloro-K; D014859:Warfarin; D010837:Vitamin K 1; D011516:Prothrombin