Retrograde enhancement of memory by mild flurothyl treatment in the chick.
Strong flurothyl treatment (1.7% v/v for 8 min) produces retrograde amnesia in chicks when administered as long as 24 hr after one-trial avoidance training with a strongly aversive stimulus. Mild flurothyl treatment (0.2% v/v for 8 min) produced retrograde enhancement when administered as long as 16 min after similar training with a moderately aversive stimulus. The moderate training followed by mild flurothyl treatment enhanced 24-hr retention to the level found after strong training alone. Enhanced retention persisted for at least 72 hr; nonspecific performance effects faded within 48 hr. The predominant dose-dependent and time-dependent enhancement effect of mild flurothyl treatment is interpreted as improved memory consolidation.
D000647:Amnesia / Q000139:chemically induced*; D000648:Amnesia, Retrograde / Q000139:chemically induced*; D000818:Animals; D000831:Animals, Newborn; D001362:Avoidance Learning / Q000187:drug effects; D002645:Chickens; D003213:Conditioning, Psychological / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D005481:Flurothyl / Q000494:pharmacology*; D006801:Humans; D008297:Male; D008568:Memory / Q000187:drug effects*; D013997:Time Factors
D005481:Flurothyl