Predictable reduction in anticoagulant activity of warfarin by small amounts of vitamin K.
After withdrawal of warfarin (Marevan), 48-72 hours are required to raise the Thombotest values from a therapeutic level (range 5-10%) to 12% or higher. By i.v. administration of 1 mg vitamin K1 (Konakion) and without changing the dose of the anticoagulant, this effect could be obtained within 24 hours. Furthermore, the effect of vitamin K vanished within 2-5 days. The use of small amounts of vitamin K may therefore be a simple and reliable way of obtaining a rapid, temporary reduction in anticoagulant effect.
D001777:Blood Coagulation / Q000187:drug effects; D001778:Blood Coagulation Disorders / Q000188:drug therapy; D004336:Drug Antagonism; D006801:Humans; D013997:Time Factors; D014812:Vitamin K / Q000494:pharmacology / Q000627:therapeutic use*; D014859:Warfarin / Q000037:antagonists & inhibitors* / Q000494:pharmacology
D014812:Vitamin K; D014859:Warfarin