Glucocorticoid-induced protection in circulatory shock: role of reticuloendotheilial system function.
Experiments with rats indicate that: (i) hydrocortisone sodium succinate (HC) and methylprednisolone sodium succine (MP) enhance survival after hemorrhage; (ii) MP is approximately 10-times more potent than HC; (iii) both HC and MP are more efficacious if administered prior to hemorrhage; (iv) efficacy of postshock therapy with both steroids is not only time- but dose-dependent; and (v) HC and MP can ameliorate or completely prevent the early RES phagocytic depression observed in circulatory shock. Overall, these data could be used to suggest that: (i) the RES may play a pivotal role in the beneficial actions of synthetic adrenocorticosteroids in circulatory shock, and (ii) numerical RES phagocytic indices may be diagnostic and prognostic parameters in circulatory shock therapy.
D000818:Animals; D004305:Dose-Response Relationship, Drug; D005260:Female; D006854:Hydrocortisone / Q000494:pharmacology / Q000627:therapeutic use*; D008775:Methylprednisolone / Q000494:pharmacology / Q000627:therapeutic use*; D012157:Mononuclear Phagocyte System / Q000187:drug effects / Q000276:immunology*; D010587:Phagocytosis; D051381:Rats; D012771:Shock, Hemorrhagic / Q000276:immunology / Q000517:prevention & control*; D013997:Time Factors
D006854:Hydrocortisone; D008775:Methylprednisolone