Sickle cell crisis treated by exchange transfusion. Treatment of two patients with heterozygous sickle cell syndrome.
In two patients with severe painful sickle cell crisis and a deteriorating clinical course, recovery coincided with large-scale exchange transfusions (6 liters). The one patient, with sickle cell beta thalassemia, achieved a 90% exchange, calculated on the sickle cell hemoglobin present before and after transfusion. The other patient, with sickle cell hemoglobin Hb A, S, and (Hb) C disease, also achieved an 80% exchange calculated on the level of HbA.S. AND C in samples before and after transfusion.
D000328:Adult; D000755:Anemia, Sickle Cell / Q000150:complications / Q000628:therapy*; D001639:Bicarbonates / Q000627:therapeutic use; D002118:Calcium / Q000627:therapeutic use; D002712:Chlorides / Q000627:therapeutic use; D005078:Exchange Transfusion, Whole Blood; D005334:Fever / Q000175:diagnosis; D006445:Hemoglobin C Disease / Q000628:therapy; D006579:Heterozygote; D006801:Humans; D008297:Male; D012964:Sodium / Q000627:therapeutic use; D013610:Tachycardia / Q000175:diagnosis; D013789:Thalassemia / Q000188:drug therapy / Q000628:therapy
D001639:Bicarbonates; D002712:Chlorides; D012964:Sodium; D002118:Calcium