Prevention of 6-hydroxydopamine neurotoxicity.
1-Phenyl-3-(2-thiazolyl)-2-thiourea (PTTU) prevented the neurotoxic actions of 6-hydroxydopamine on adrenergic nerves in the mouse atrium and iris. This is the first reported 6-hydroxydopamine antagonist that does not act by blocking uptake of catecholamines into nerve terminals. PTTU also prevented the diabetogenic action of alloxan.
D000818:Animals; D003921:Diabetes Mellitus, Experimental / Q000517:prevention & control; D006325:Heart Atria / Q000294:innervation / Q000378:metabolism; D006892:Hydroxydopamines / Q000037:antagonists & inhibitors*; D007498:Iris / Q000294:innervation / Q000378:metabolism; D008297:Male; D051379:Mice; D009411:Nerve Endings / Q000187:drug effects; D009474:Neurons / Q000187:drug effects*; D009638:Norepinephrine / Q000378:metabolism; D010668:Phenylthiazolylthiourea / Q000494:pharmacology* / Q000627:therapeutic use; D010670:Phenylthiourea / Q000031:analogs & derivatives*; D013564:Sympathetic Nervous System / Q000187:drug effects*
D006892:Hydroxydopamines; D010668:Phenylthiazolylthiourea; D010670:Phenylthiourea; D009638:Norepinephrine