Synthesis and biological properties of some novel heterocyclic homoprostanoids.
In the search for prostaglandin-like structures capable of exerting specific and desirable biological properties, a variety of simple heterocyclic homoprostanoidal derivatives was synthesized from readily available stearic acid derivatives. Compounds 5b and 5e were found to be more than 100 times as potent as PGE1 and PGE2 in a tracheal chain bioassay and, like 6, 9, and 12, inhibited PGE2-induced diarrhea. Derivatives 6 and 7a showed significant PG-synthetase inhibitor activity.
D000818:Animals; D002415:Cats; D003864:Depression, Chemical; D003967:Diarrhea / Q000139:chemically induced; D004149:Dioxoles / Q000138:chemical synthesis / Q000494:pharmacology; D006168:Guinea Pigs; D066298:In Vitro Techniques; D008297:Male; D051379:Mice; D009119:Muscle Contraction / Q000187:drug effects; D009130:Muscle, Smooth / Q000187:drug effects; D011453:Prostaglandins / Q000096:biosynthesis / Q000138:chemical synthesis* / Q000494:pharmacology; D011458:Prostaglandins E / Q000037:antagonists & inhibitors; D051381:Rats; D013440:Sulfides / Q000138:chemical synthesis / Q000494:pharmacology; D013871:Thiones / Q000138:chemical synthesis / Q000494:pharmacology; D014132:Trachea / Q000187:drug effects
D004149:Dioxoles; D011453:Prostaglandins; D011458:Prostaglandins E; D013440:Sulfides; D013871:Thiones