Comparative bioavailabilities from truncated blood level curves.
The period of time after administration over which blood level measurements are required to obtain a reliable bioavailability comparison of two or more formulations of the same drug was considered by the analysis of bioavailability data taken from the literature. The drugs examined, selected to represent a range of absorption and elimination half-lives, were acetaminophen, aminosalicylic acid, chloramphenicol, chlordiazepoxide, digoxin, isoniazid, phenylbutazone, sulfamethizole, tetracycline, and warfarin. For most drugs, ratios of areas under the curve changed little between the end of the absorption period and the time when blood sampling was terminated. Reliable bioavailability comparisons among different brands of the drugs apparently could have been made by blood sampling over 24 hr or less.
D000082:Acetaminophen / Q000097:blood; D000636:Aminosalicylic Acids / Q000097:blood; D001682:Biological Availability; D001702:Biopharmaceutics; D002701:Chloramphenicol / Q000097:blood; D002707:Chlordiazepoxide / Q000097:blood; D004077:Digoxin / Q000097:blood; D006801:Humans; D007538:Isoniazid / Q000097:blood; D007700:Kinetics; D004364:Pharmaceutical Preparations / Q000097:blood*; D010653:Phenylbutazone / Q000097:blood; D013419:Sulfamethizole / Q000097:blood; D013752:Tetracycline / Q000097:blood; D013997:Time Factors; D014859:Warfarin / Q000097:blood
D000636:Aminosalicylic Acids; D004364:Pharmaceutical Preparations; D013419:Sulfamethizole; D000082:Acetaminophen; D014859:Warfarin; D002701:Chloramphenicol; D002707:Chlordiazepoxide; D004077:Digoxin; D013752:Tetracycline; D010653:Phenylbutazone; D007538:Isoniazid