Lidoplazine and Na and K distribution in normo-and hypokalaemic rats.
The effects of lidoplazine on K-metabolism were investigated in two types of experiments. (1) K and Na concentrations were measured in plasma, heart, diaphragm and erythrocytes in normo- and hypokalaemic rats with or without chronic (1 month) lidoplazine treatment. Total body weight, heart weight, dry weight/wet weight ratios and extracellular space were also determined. (2) Radioactive K influx in the heart was measured in acute in vitro experiments with or without lidoplazine. It is demonstrated that while lidoflazine has no effect on the Na and K distribution of normokalaemic animals, it has rather a K-saving effect in conditions of severe loss of intra- and extracellular K-ions. In normal in vitro preparations the unidirectional K-influx is not affected by lidoflazine.
D000818:Animals; D001834:Body Water / Q000378:metabolism; D001835:Body Weight / Q000187:drug effects; D003964:Diaphragm / Q000378:metabolism; D004912:Erythrocytes / Q000378:metabolism; D005110:Extracellular Space / Q000378:metabolism; D006321:Heart / Q000187:drug effects; D006325:Heart Atria / Q000378:metabolism; D006352:Heart Ventricles / Q000378:metabolism; D007008:Hypokalemia / Q000378:metabolism*; D008013:Lidoflazine / Q000494:pharmacology*; D008297:Male; D009929:Organ Size / Q000187:drug effects; D010879:Piperazines / Q000494:pharmacology*; D011188:Potassium / Q000378:metabolism*; D011191:Potassium Deficiency / Q000378:metabolism; D051381:Rats; D012964:Sodium / Q000378:metabolism*
D010879:Piperazines; D012964:Sodium; D008013:Lidoflazine; D011188:Potassium