Efficacy of Fenbendazole against gastrointestinal parasites of sheep.
Lambs severely parasitized by Haemonchus, Ostertagia, Trichostrongylus, Cooperia, Oesophagostomum, and Nematodirus were treated with fenbendazole (methyl 5-(phenylthio)-2-benzimidazolecarbamate) given at 3 dose levels: 3.5, 5.0, and 7.5 mg/kg of body weight. Efficacies against these genera, except Haemonchus and Nematodirus, were 100% at the 3 dose levels. Efficacies for the 3 doses against Haemonchus were 93.4, 95.3, and 99.8%, respectively, and against Nematodirus, 99.5, 99.6, and 100%. Efficacies for the doses against Trichuris were 69.1, 83.6, and 98.2%. Toxicosis due to the durg was not seen in these lambs, although they were severely debilitated.
D000818:Animals; D001562:Benzimidazoles / Q000627:therapeutic use*; D002219:Carbamates / Q000627:therapeutic use*; D006188:Haemonchiasis / Q000662:veterinary; D006374:Helminthiasis, Animal; D007411:Intestinal Diseases, Parasitic / Q000662:veterinary*; D008989:Monieziasis / Q000188:drug therapy; D009814:Oesophagostomiasis / Q000662:veterinary; D010029:Ostertagiasis / Q000662:veterinary; D012756:Sheep; D012757:Sheep Diseases / Q000188:drug therapy*; D013272:Stomach Diseases / Q000662:veterinary*; D014252:Trichostrongyloidiasis / Q000662:veterinary; D014253:Trichostrongylosis / Q000662:veterinary; D014257:Trichuriasis / Q000662:veterinary
D001562:Benzimidazoles; D002219:Carbamates