[Effect of alcohol and diet on some liver enzymes].
Liver is the main organ associated with alcohol oxidation. The definite liver enzymes role is not elucidated as yet, that participates in alcohol metabolism. The nutrient factors are of a great importance for the development of the alcoholic liver lesions and for the induction of liver enzymes under alcohol effect. Alcohol effect was studied in 80 male albino rats, Wistar strain, as well as some nutritional diets upon microsomal enzymes--cytochrome P-450, aniline-hydroxilase aminopyrine-demetilase., ADH and DALA-C. The changes, developed in the body weight are discussed as well as the liver weight and the microsomal protein under alcohol effect and the respective nutritional regimens. Alcohol, given in a dose of 4g/kg body weight, in the course of 60 days, induces but slightly the microsomal enzymes cytochrome P-450 and aniline-hydroxilase and does not induce aminopyrine-demetilase. ADH activity decrease with the chronic alcohol loading. Mitochondrial enzyme DALA-C is moderately induced by alcohol. Lipid and protein role is decisive in the induction process while the carbohydrate role is less.
D000429:Alcohol Oxidoreductases / Q000378:metabolism; D000622:Aminolevulinic Acid / Q000378:metabolism; D000633:Aminopyrine N-Demethylase / Q000378:metabolism; D000815:Aniline Hydroxylase / Q000378:metabolism; D000818:Animals; D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism; D004032:Diet; D004040:Dietary Carbohydrates; D004041:Dietary Fats; D004044:Dietary Proteins; D000431:Ethanol / Q000378:metabolism / Q000494:pharmacology*; D008099:Liver / Q000187:drug effects / Q000201:enzymology*; D008297:Male; D008930:Mitochondria, Liver / Q000187:drug effects / Q000201:enzymology; D010088:Oxidoreductases / Q000378:metabolism*; D051381:Rats
D004040:Dietary Carbohydrates; D004041:Dietary Fats; D004044:Dietary Proteins; D000431:Ethanol; D000622:Aminolevulinic Acid; D003577:Cytochrome P-450 Enzyme System; D010088:Oxidoreductases; D000429:Alcohol Oxidoreductases; D000815:Aniline Hydroxylase; D000633:Aminopyrine N-Demethylase
Efekt na alkokhola i khranitelniia rezhim v"rkhu niakoi chernodrobni enzimi