[Tissue-specific depression of DNA synthesis by calcium salt-free liver and lung extracts that are able to increase the stability of cell linkage in the tissue].
The macromolecular fraction of Ca-free salt extracts (Ca-FSE) removed from lungs and liver of adult rats, mice and fishes inhibits DNA synthesis in the embryonic tissue. The effect of Ca-FSE is tissue-specific rather than species-specific. Ca-FSE was earlier reported to increase with the same specificity the tissue stability to mechanical disruption. A concept is proposed that the tissue-specific adhesive factor may play the role of G1-chalone in epithelial tissue.
D000818:Animals; D002118:Calcium / Q000502:physiology*; D002478:Cells, Cultured; D004247:DNA / Q000037:antagonists & inhibitors*; D004305:Dose-Response Relationship, Drug; D004622:Embryo, Mammalian / Q000187:drug effects; D004625:Embryo, Nonmammalian; D005399:Fishes; D008040:Genetic Linkage / Q000187:drug effects*; D008099:Liver / Q000166:cytology; D008168:Lung / Q000166:cytology; D051379:Mice; D008805:Mice, Inbred A; D051381:Rats; D013045:Species Specificity; D013997:Time Factors; D014020:Tissue Extracts / Q000494:pharmacology*
D014020:Tissue Extracts; D004247:DNA; D002118:Calcium
Tkanevospetsificheskoe ugnetenie sinteza DNK beskal' tsievymi solevymi ékstraktami iz pechemi i legkogo, obladaiushchimi sposobnost' uvelichivat' prochnost' stsepleniia kletok v tkani