Septal lesions and behavior: effects of presurgical rearing and strain of mouse.
Male mice (C57BL/10J or SJL/J strains) were reared in either enriched social cages or restricted individual cages from 25 days of age until they underwent septal or control surgery 1 mo later. Enrichment differentially altered septal or control behavior as measured by: fluid consumption of water, saccharin, and quinine; performance on a rotorod; and the acquisition of an active avoidance task. The interactions of presurgical history with brain damage were manifested differently in the two strains of mice. The importance of attending more to genetic and presurgical history in attempts to define the effects of brain damage on behavior and to determine the function of brain structures is discussed.
D000818:Animals; D001362:Avoidance Learning / Q000502:physiology*; D001522:Behavior, Animal; D004327:Drinking Behavior / Q000502:physiology*; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D008815:Mice, Inbred Strains / Q000502:physiology*; D009048:Motor Skills / Q000502:physiology; D011803:Quinine; D012439:Saccharin; D012688:Septum Pellucidum / Q000502:physiology*; D012931:Social Environment; D012934:Social Isolation; D013649:Taste / Q000502:physiology; D014867:Water
D014867:Water; D011803:Quinine; D012439:Saccharin