Dopaminergic neurons in the nigro-striatal and mesolimbic pathways: mediation of specific effects of D-amphetamine.
The administration of d-amphetamine (15 mg/kg, i.p.) to rats causes stereotypy, hypothermia among animals placed in a cold environment, and paradoxical behavioral thermoregulation (i.e., animals in a cold environment choose not to place themselves under the beam emitted by a heat lamp). These effects are blocked in animals lesioned unilaterally in the mesolimbic dopaminergic projections to the olfactory tubercule and nucleus accumbens. In contrast, a unilateral lesion destroying the nigro-striatal projections within the caudate nucleus blocks none of these responses, and actually potentiates the induction of stereotypy by d-amphetamine. Both lesions cause the animal to exhibit rotational behavior in response  to the subsequent administration of d-amphetamine. These observations suggest that the mesolimbic dopaminergic projections mediate some of the behavioral and visceral effects of d-amphetamine.
D000818:Animals; D001833:Body Temperature Regulation / Q000187:drug effects; D003342:Corpus Striatum / Q000502:physiology*; D003913:Dextroamphetamine / Q000494:pharmacology*; D004298:Dopamine / Q000502:physiology*; D006801:Humans; D008032:Limbic System / Q000502:physiology*; D008297:Male; D009474:Neurons / Q000502:physiology*; D009830:Olfactory Bulb / Q000502:physiology; D051381:Rats; D013239:Stereotyped Behavior / Q000187:drug effects
D003913:Dextroamphetamine; D004298:Dopamine