Influence of dosage regimen on responses of the arcuate nucleus to subcutaneous injection of a protein hydrolysate.
The effect of administration of a glutamate-containing protein hydrolysate on the arcuate nucleus of 10-day-old mice was studied by two methods. Arcuate nucleus damage resulted when administration was by a single large subcutaneous dose (100 ml/kg). When the same total dose was administered subcutaneously in five small doses (20 ml/kg) over a period of 8 h, the damage to the arcuate nucleus did not occur. The latter method of administration was to simulate a clinical infusion. The results demonstrate that there is no hazard to the arcuate nucleus w-en glutamate-containing protein hydrolysates are administered by infusion.
D000818:Animals; D002364:Caseins; D004334:Drug Administration Schedule; D005260:Female; D007031:Hypothalamus / Q000166:cytology / Q000187:drug effects; D007279:Injections, Subcutaneous; D008297:Male; D051379:Mice; D011492:Protein Hydrolysates / Q000008:administration & dosage / Q000494:pharmacology*
D002364:Caseins; D011492:Protein Hydrolysates