Effects of nerve growth factor administration of N-ethyl-N-nitrosourea carcinogenesis.
We attempted to determine whether the sympathetic nervous system in rodents is susceptible to co-carcinogenesis, employing murine salivary nerve growth factor (NGF) as a co-carcinogenic agent. NGF had no co-carcinogenic effect with either methylcholanthrene or ethylnitrosourea (ENU) on the sympathetic nervous system of the mouse, whether administered transplacentally, postnatally, or both transplacentally and postnatally. At a dose of ENU of 30 mug/g body weight, NGF did not shorten the latent period for tumor induction of BD-IX rats. In contrast, a 25% reduction in latent period was brough about by NGF for tumor appearance in BD-IX rats receiving 90 mug/g ENU. In both cases the frequency of urogenital tumors in rats was increased as a result of NGF administration, at the apparent expense of neural tumors.
D000818:Animals; D001932:Brain Neoplasms / Q000139:chemically induced* / Q000401:mortality; D002478:Cells, Cultured; D004347:Drug Interactions; D005038:Ethylnitrosourea / Q000008:administration & dosage; D005260:Female; D008297:Male; D008748:Methylcholanthrene; D009374:Neoplasms, Experimental / Q000139:chemically induced; D009414:Nerve Growth Factors / Q000302:isolation & purification / Q000494:pharmacology*; D009447:Neuroblastoma / Q000139:chemically induced* / Q000401:mortality; D009607:Nitrosourea Compounds; D011247:Pregnancy; D051381:Rats; D014565:Urogenital Neoplasms / Q000139:chemically induced*
D009414:Nerve Growth Factors; D009607:Nitrosourea Compounds; D008748:Methylcholanthrene; D005038:Ethylnitrosourea