[Evaluation of the skin resorptive action of testosterone and its esters].
The skin-resorptive action of testosterone and of its ethers (propionate, phenylpropionate, isocapronate, enantate, caprinate) was studied on castrated albino male rats with a one-time application to the skin. The effect was assessed by the growth of the seminal vesicles and the ventral lobe of the prostate. The highest skin-resorptive activity displayed testosterone-propionate and the lowest--testosterone-caprinate. The maximum effect following application of all the studied substances was registered on the 2-3d day. The amount of the maximum active dose (0,1 mg per animal) warrants including these compounds in a group of highly dangerous substances producing a skin-resorptive action.
D000818:Animals; D002369:Castration; D004305:Dose-Response Relationship, Drug; D008297:Male; D009929:Organ Size / Q000187:drug effects; D011467:Prostate / Q000187:drug effects; D051381:Rats; D012669:Seminal Vesicles / Q000187:drug effects; D012869:Skin Absorption / Q000187:drug effects*; D013268:Stimulation, Chemical; D013739:Testosterone / Q000008:administration & dosage / Q000031:analogs & derivatives / Q000494:pharmacology*; D013997:Time Factors
D013739:Testosterone
K otsenke kozhno-rezorbtivnogo deĭstviia testosterona i ego éfirov