Evaluation of coal tar fractions for use in psoriasiform diseases using the mouse tail test. (II) Tar oil acids.
Mouse tail scale epidermis was used as a model to evaluate anti-parakeratotic activity of tar oil acids (phenols) boiling between 175 and 400 degrees C. Lower boiling phenols seemed to cause more irritation, whereas high boiling phenols caused granular layer induction in formerly parakeratotic skin.
D000818:Animals; D055598:Chemical Phenomena; D002621:Chemistry; D003033:Coal Tar / Q000627:therapeutic use*; D003408:Cresols / Q000627:therapeutic use; D004195:Disease Models, Animal; D004341:Drug Evaluation; D051379:Mice; D009824:Ointments; D010636:Phenols / Q000008:administration & dosage / Q000627:therapeutic use*; D011565:Psoriasis / Q000188:drug therapy*; D012627:Sebaceous Glands / Q000187:drug effects; D012867:Skin / Q000187:drug effects*; D013696:Temperature
D003408:Cresols; D009824:Ointments; D010636:Phenols; D003033:Coal Tar