Acute toxicity and the influence of some undecane, cyclopentylpentane and pyridine alpha- and beta-carboxylic acid derivatives on the increased hyperlipemia in rats.
Acute toxicity and hypolipaemic properties of 17 new compounds were studied in the tyloxapol test. Out of these, sodium salts of 1-chloro-2,6,10-trimethylundecane-1-carboxylic acid (I-2) and of 2-hydroxy-2-methyl-5 (2(2),2(2),3(2)-trimethylcyclopenten-3(2)yl)-pent-3-en-1-carboxylic acid (V) have hypolipemic activity.
D000818:Animals; D001786:Blood Glucose / Q000032:analysis; D003517:Cyclopentanes / Q000494:pharmacology* / Q000633:toxicity; D005227:Fatty Acids / Q000494:pharmacology* / Q000633:toxicity; D005260:Female; D006949:Hyperlipidemias / Q000139:chemically induced; D000960:Hypolipidemic Agents; D007928:Lethal Dose 50; D008055:Lipids / Q000097:blood*; D008297:Male; D051379:Mice; D011725:Pyridines / Q000494:pharmacology* / Q000633:toxicity; D051381:Rats
D001786:Blood Glucose; D003517:Cyclopentanes; D005227:Fatty Acids; D000960:Hypolipidemic Agents; D008055:Lipids; D011725:Pyridines