Depression of taste responses by local or intravascular administration of salicylates in the rat.
The effects of aspirin and sodium salicylate on the taste response in the chorda tympani proper nerve have been studied during stimulation of the taste receptors in rats with salty, sweet, sour and bitter-tasting solutions. Three methods of administering the drugs were used: locally on the tongue, intravenously into one femoral vein and intraarterially close to the branching of the lingual artery. It was observed that salicylates, given in any of these three ways, depressed the response to taste stimuli. This is discussed in relation to present views on the action of salicylates.
D000287:Administration, Topical; D000818:Animals; D001241:Aspirin / Q000008:administration & dosage / Q000494:pharmacology*; D003864:Depression, Chemical; D007213:Indomethacin / Q000494:pharmacology; D007269:Injections, Intra-Arterial; D007275:Injections, Intravenous; D008297:Male; D051381:Rats; D012965:Sodium Chloride; D012980:Sodium Salicylate / Q000008:administration & dosage / Q000494:pharmacology*; D013650:Taste Buds / Q000187:drug effects*
D012965:Sodium Chloride; D001241:Aspirin; D012980:Sodium Salicylate; D007213:Indomethacin