Correlation between specific immunity to a metabolite of halothane and hepatic lesions after multiple exposures.
A correlation between the use of halogenated anesthetic agents and liver necrosis is not yet established in man. In an attempt to resolve this dilemma, guinea pigs were immunized with a complex of guinea-pig albumin and trifluoroacetate (TFA), a common metabolite of halothane and fluorexene, and then exposed to halothane on multiple occasions. Histology and liver-function tests showed no difference in the incidence of liver damage between groups of animals immune to TFA with cellular immunity and untreated control animals. However, a difference in the liver enzyme levels was seen between controls and animals showing humoral immunity.
D000818:Animals; D000917:Antibody Formation / Q000187:drug effects; D056486:Chemical and Drug Induced Liver Injury; D004305:Dose-Response Relationship, Drug; D006168:Guinea Pigs / Q000276:immunology; D006221:Halothane / Q000494:pharmacology*; D007249:Inflammation / Q000503:physiopathology; D008099:Liver / Q000187:drug effects / Q000201:enzymology / Q000276:immunology / Q000503:physiopathology*; D009336:Necrosis / Q000209:etiology; D014269:Trifluoroacetic Acid / Q000494:pharmacology
D014269:Trifluoroacetic Acid; D006221:Halothane