GLC determination of 7-chloro-5,11-dihydrodibenz[b,e][1,4]-oxazepine-5-carboxamide in serum or plasma.
This report describes the isolation, derivative formation, GLC, and quantitation of unmetabolized 7-chloro-5,11-dihydrodibenz[b,e][1,4]oxazepine-5-carboxamide (I) in blood serum or plasma. Carbamazepine is used as the internal standard to compensate for losses of I during extraction and handling. Essentially complete recovery (100 +/- 6%) was demonstrated over a concentration range of 1-30 mug of I/ml of serum.
D002849:Chromatography, Gas; D003989:Dibenzoxazepines / Q000097:blood* / Q000652:urine; D013058:Mass Spectrometry; D008722:Methods; D009570:Nitriles / Q000097:blood
D003989:Dibenzoxazepines; D009570:Nitriles