Temperature and behavioural responses induced in the unanaesthetized cat by the central administration of RX72601, a new anticholinesterase.
1 The central effects produced by a new anticholinesterase RX72601 injected into the cerebral ventricles or perfused within circumscribed forebrain structures have been investigated in the unanesthetized cat. 2 When injected into the cerebral ventricles in doses of 1-10 mug, RX72601 produced a dose-related hyperthermia together with behavioural and autonomic responses. 3 Experiments designed to localize the site or sites of these actions demonstrated that hyperthermia could be produced from several diencephalic sites but that the other effects were not normally produced from these same sites.
D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects*; D001831:Body Temperature / Q000187:drug effects*; D001921:Brain / Q000033:anatomy & histology; D002415:Cats; D002800:Cholinesterase Inhibitors / Q000008:administration & dosage / Q000494:pharmacology*; D003510:Cyclohexanes / Q000008:administration & dosage / Q000494:pharmacology*; D005260:Female; D007276:Injections, Intraventricular; D008297:Male; D009388:Neostigmine / Q000494:pharmacology; D010477:Perfusion; D011759:Pyrrolidines / Q000008:administration & dosage / Q000494:pharmacology*; D013997:Time Factors
D002800:Cholinesterase Inhibitors; D003510:Cyclohexanes; D011759:Pyrrolidines; D009388:Neostigmine