Effect of stress on the pharmacokinetics of sodium salicylate and quinidine sulphate in rats.
Studies on the influence of foot shock stress on the absorption, distribution and overall serum elimination of sodium salicylate and guinidine sulphate were performed in rats. Foot shock stress was produced by grid floor electrical stimulation. The animals were stressed 1 hr before administration of the drugs and then throughout the experimental period. A significant induced stress was demonstrated by increased blood glucose levels and increased whole brain turnover of noradrenaline. Gastric emptying and intestinal transit as well as tissue levels of the drugs in the serum, heart, brain, liver, muscle and fat were determined. Results were obtained indicating that stress produced a significant increase in the gastro-intestinal absorption of quinidine sulphate while no change in the distribution pattern of overall elimination was noted. On the other hand, sodium salicylate did not show any marked change in the pharmacokinetic parameters during a stressful situation.
D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D004558:Electric Stimulation; D005769:Gastrointestinal Motility / Q000187:drug effects; D007408:Intestinal Absorption / Q000187:drug effects; D008297:Male; D009638:Norepinephrine / Q000378:metabolism; D011802:Quinidine / Q000494:pharmacology; D051381:Rats; D012980:Sodium Salicylate / Q000494:pharmacology; D013312:Stress, Physiological / Q000378:metabolism; D013997:Time Factors
D001786:Blood Glucose; D011802:Quinidine; D012980:Sodium Salicylate; D009638:Norepinephrine