[Streptomycin and kanamycin level in the blood and lungs of guinea pigs when the antibiotics are administered by inhalation and intramuscularly].
Streptomycin and kanamycin levels in the blood and lung tissue after the antibiotic inhalation or intramuscular administration were studied comparatively on 86 healthy guinea pigs. The antibiotics were inhaled with the help of the nozzle or ultrasonic aerozol apparatus. The studies showed statistically reliable advantages of the ultrasonic aerosols in attaining high levels of streptomycin and kanamycin preserved for prolonged periods of time in the lungs of the experimental animals as compared to the intramuscular administration route or the aerosols introduced with the help of the pneumatic inhaler. After inhalation of the ultrasonic aerosols the levels of streptomycin in the lung tissue of the guinea pigs were 5 times higher than those after inhalation of the nozzle aerosols and 64 times higher than those after the antibiotic intramuscular administration. As for kanamycin the respective values were 2 and 14 times higher.
D000336:Aerosols; D000818:Animals; D004781:Environmental Exposure; D006168:Guinea Pigs; D007273:Injections, Intramuscular; D007612:Kanamycin / Q000008:administration & dosage* / Q000032:analysis; D008168:Lung / Q000032:analysis*; D013307:Streptomycin / Q000008:administration & dosage* / Q000032:analysis; D013997:Time Factors; D014465:Ultrasonics
D000336:Aerosols; D007612:Kanamycin; D013307:Streptomycin
Soderzhanie streptomitsina i kanamitsina v krovi i legkikh morskikh svinok pri ingaliatsionnom i vnutrimyshechnom vvedenii antibiotikov