Pharmacological properties of the plasticizer, acetyl N-tributyl citrate, and its extraction from poly(vinyl chloride) tubing.
Aqueous extracts of a PVC transfusion tubing contracted isolated guinea-pig ilea. A pharmacological and chemical study (infrared spectroscopy, gas-liquid chromatography) showed that this was due to extraction of the plasticizer, acetyl N-tributyl citrate (ATBC). The concentrations of ATBC to produce contractions of the isolated guinea-pig ileum (from 1 mug/ml) can be compared with those achieved after recirculating tubing under conditions simulating use (up to 6 mug/ml). In assessing the toxicity of plastic tubing, there is a need to determine extraction of consituents under conditions simulating use and the effects of such extracts on a variety of tissues.
D000818:Animals; D001672:Biocompatible Materials / Q000494:pharmacology*; D002849:Chromatography, Gas; D002853:Chromatography, Liquid; D002951:Citrates / Q000032:analysis / Q000494:pharmacology*; D006168:Guinea Pigs; D007082:Ileum / Q000187:drug effects; D007440:Intubation / Q000295:instrumentation*; D009119:Muscle Contraction / Q000187:drug effects; D011143:Polyvinyl Chloride / Q000032:analysis*; D011145:Polyvinyls / Q000032:analysis*
D001672:Biocompatible Materials; D002951:Citrates; D011145:Polyvinyls; D011143:Polyvinyl Chloride