Failure to induce hypersensitivity reactions to opaque contrast media analogs in guinea pigs.
In a further exploration of idiosyncratic reactions to injections of contrast media, a systematic study of immediate or delayed hypersensitivity in guinea pigs injected with contrast media analogs was performed. No evidence of immediate or delayed hypersensitivity could be ascertained to either contrast media analogs alone, or analogs bound to protein carriers. This does not represent conclusive evidence against the notion of antibody formation as a factor in the production of some adverse reactions, but makes such a pathogenesis less likely.
D000100:Acetrizoic Acid / Q000276:immunology*; D000818:Animals; D000917:Antibody Formation; D000918:Antibody Specificity; D000936:Antigen-Antibody Complex; D000941:Antigens; D003287:Contrast Media / Q000009:adverse effects; D003973:Diatrizoate / Q000276:immunology*; D006168:Guinea Pigs; D006968:Hypersensitivity, Delayed / Q000276:immunology*; D006969:Hypersensitivity, Immediate / Q000276:immunology*; D007463:Iodobenzoates / Q000276:immunology*; D008297:Male; D008794:Metrizoic Acid / Q000276:immunology*; D010047:Ovalbumin; D010323:Passive Cutaneous Anaphylaxis; D012710:Serum Albumin, Bovine; D012882:Skin Tests
D000936:Antigen-Antibody Complex; D000941:Antigens; D003287:Contrast Media; D007463:Iodobenzoates; D003973:Diatrizoate; D000100:Acetrizoic Acid; D012710:Serum Albumin, Bovine; D010047:Ovalbumin; D008794:Metrizoic Acid