Acute liver failure and encephalopathy (Reye's syndrome?) during salicylate therapy.
A case of hepatotoxicity and encephalopathy (Reye's syndrome?) associated with salicylate therapy is presented and the aetiology of this syndrome is discussed. Hepatotoxicity developed with salicylate serum concentrations not exceeding therapeutic serum levels. The importance of controlling serum salicylate concentration and transaminase activity particularly during the first fourteen days of therapy is emphasized.
D000208:Acute Disease; D000293:Adolescent; D001241:Aspirin / Q000009:adverse effects*; D001927:Brain Diseases / Q000139:chemically induced*; D056486:Chemical and Drug Induced Liver Injury; D005260:Female; D006801:Humans; D008099:Liver / Q000187:drug effects*; D012202:Reye Syndrome / Q000139:chemically induced*; D012459:Salicylates / Q000097:blood
D012459:Salicylates; D001241:Aspirin