[On the toxicity of CT-1341 evoked by long-term administration. II. Subacute and chronic toxicities of alphaxalone in rats (author's transl)].
Alphaxalone, an anesthetic steroid dissolved in 20% Cremophor solution was administered intraperitoneally to test the subacute toxicity (administration for one month) and chronic toxicity (administration for 3 months). In daily doses less than 8 mg/kg, alphaxalone did not show any particular toxic sign after administered for three months. Rats tolerated to daily administration of 20 mg/kg for three months, without showing severe toxic signs in body weight curve, blood cells and biochemical data obtained in blood and urine. However, some female rats receiving 50 mg/kg/day of alphaxalone, died by paralysis of respiratory center at the second day. Main histo-pathological changes induced by subacute and chronic administrations of the larger doses than 20 mg/kg, were swelling of cells in the liver and kidneys, but severe pathological changes were not seen in any organs.
D000530:Alfaxalone Alfadolone Mixture / Q000008:administration & dosage / Q000633:toxicity*; D000771:Anesthesia, Intravenous; D000818:Animals; D001835:Body Weight / Q000187:drug effects; D005260:Female; D007274:Injections, Intraperitoneal; D007668:Kidney / Q000033:anatomy & histology; D007684:Kidney Tubules / Q000473:pathology; D008099:Liver / Q000033:anatomy & histology; D008297:Male; D009929:Organ Size / Q000187:drug effects; D011277:Pregnanediones / Q000633:toxicity*; D051381:Rats; D012133:Respiratory Paralysis / Q000139:chemically induced; D012737:Sex Factors; D013997:Time Factors
D011277:Pregnanediones; D000530:Alfaxalone Alfadolone Mixture