Cytotoxic principles of Parquetina nigrescens (Afzel.) Bullock (Asclepiadaceae).
Systematic fractionation of the cytotoxic extracts of the roots of Parquetina nigrescens (Afzel.) Bullock (Asclepiadaceae) on silica gel column chromatography led to the isolation of three cardenolides: cymarin, strophanthidin, and a strophanthidin glycoside (XS-89). Also isolated during the investigation were beta-sitosterol-beta-D-glucoside, a mixture of alpha- and beta-amyrins, a mixture of alkanols, and a mixture of plant sterols.
D000818:Animals; D000970:Antineoplastic Agents / Q000302:isolation & purification* / Q000627:therapeutic use; D002301:Cardiac Glycosides / Q000302:isolation & purification* / Q000627:therapeutic use; D003529:Cymarine / Q000302:isolation & purification; D007942:Leukemia, Experimental / Q000188:drug therapy; D010840:Phytosterols / Q000302:isolation & purification; D010936:Plant Extracts / Q000302:isolation & purification / Q000627:therapeutic use; D010944:Plants / Q000032:analysis*; D012855:Sitosterols / Q000302:isolation & purification; D013327:Strophanthidin / Q000302:isolation & purification
D000970:Antineoplastic Agents; D002301:Cardiac Glycosides; D010840:Phytosterols; D010936:Plant Extracts; D012855:Sitosterols; D013327:Strophanthidin; D003529:Cymarine