[Effect of aminazine on the lymphocyte blast transformation].
Chlorpromazine used in low concentrations during in vivo experiments stimulates the lymphocytes blast transformation reaction (LBR) in the blood of donors and in that of rabbits, while in large doses it suppresses this reaction. When LBR is stimulated with phitohemagglutinin (PHA), chlorpromazine weakens the reaction. Follwing a single intravenous injection of chlorpromazine to a rabbit the spontaneous LBR rises, while the stimulating effect of PHA declines. After a repeated introduction there of there are on the rise: spontaneous LBR, the reactions developing in response to PHA, the phenomenon of inhibition with chlorpromazine of the blast reaction stimulation, caused by PHA.
D000818:Animals; D001782:Blood Donors; D002478:Cells, Cultured; D002746:Chlorpromazine / Q000008:administration & dosage / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D006801:Humans; D007111:Immunity, Cellular / Q000187:drug effects; D007165:Immunosuppression Therapy; D066298:In Vitro Techniques; D037102:Lectins / Q000494:pharmacology; D008213:Lymphocyte Activation / Q000187:drug effects*; D011817:Rabbits; D013997:Time Factors
D037102:Lectins; D002746:Chlorpromazine
Vliianie aminazine na reaktsiiu blasttransformatsii limfotsitov