[Experimental data on hygienic norms for antibiotics of the tetracycline group].
Toxicity of tetracyclines was studied experimentally on different species of laboratory animals. It was shown that tetracycline, oxytetracycline and chlortetracycline were close by their chemical structure and physico-chemical properties, as well as by the main toxicity parameters, i.e. acute toxicity, cumulative activity, skin-irritating and sensitizing effect. Under the conditions of subacute experiments the above 3 antibiotics induced evenly pronounced one direction changes in animals. The data obtained during the experiments provided recommendation of the level of 0.1 mg/m3 as the maximum allowable concentration (MAC) of oxytetracycline and chlortetracycline, i.e. the same level as the previously recommended for tetracycline.
D000284:Administration, Oral; D000818:Animals; D002751:Chlortetracycline / Q000633:toxicity; D004342:Drug Hypersensitivity / Q000276:immunology; D006168:Guinea Pigs; D007928:Lethal Dose 50; D008452:Maximum Allowable Concentration; D051379:Mice; D010118:Oxytetracycline / Q000633:toxicity; D051381:Rats; D013045:Species Specificity; D013752:Tetracycline / Q000633:toxicity; D013754:Tetracyclines / Q000633:toxicity*; D013997:Time Factors
D013754:Tetracyclines; D013752:Tetracycline; D002751:Chlortetracycline; D010118:Oxytetracycline
Eksperimental'nye materialy k gigienicheskomu normirovaniiu antibiotikov tetratsiklinovoĭ gfuppy