Disaccharidase activities in intestinal metaplasia - contribution of lysosomal brush border enzymes.
Maltase, sucrase, and lactase were measured at pH 4 and pH 6 in normal and intestinalized gastric mucosa. In the normal mucosa the low activities of maltase and lactase seemed to be entirely due to lysosomal enzymes with acid pH-optimum. In intestinal metaplasia, brush border maltase and sucrase, but not lactase, appeared. On the other hand, there was a significant increase in lysosomal lactase (beta-galactosidase) activity.
D004186:Disaccharidases / Q000378:metabolism*; D005753:Gastric Mucosa / Q000201:enzymology* / Q000473:pathology; D006801:Humans; D007410:Intestinal Diseases / Q000201:enzymology*; D007785:Lactose / Q000378:metabolism; D008247:Lysosomes / Q000201:enzymology*; D008320:Maltose / Q000378:metabolism; D008679:Metaplasia; D013393:Sucrase / Q000378:metabolism
D008320:Maltose; D004186:Disaccharidases; D013393:Sucrase; D007785:Lactose