[Effect of a protein-free hemoderivative on recovering capability of rat liver following 60 minutes of hemorrhagic shock].
The effect of the protein-free standardized blood extract from calves Actihaemyl on the concentration of ATP, ADP, AMP, lactate, pyruvate, beta-hydroxybutyrate, acetoacetate and glycogen of the rat liver after a 60 min hemorrhagic shock and recovery times of 30, 60 and 120 min has been investigated. Actihaemyl lowered the shock induced increased values of lactate and beta-hydroxybutyrate within the first 30 and 60 min after termination of shock at a faster rate than did the placebo. Consequently, the ratios lactate/pyruvate and beta-hydroxybutyrate/acetoacetate were found to be decreased. The remaining parameters showed no significant differences between the placebo and the Actihaemyl group. The results suggest that Actihaemyl increases the oxydative energy metabolism after a hemorrhagic shock.
D000090:Acetoacetates / Q000032:analysis; D000183:Actihaemyl / Q000494:pharmacology*; D000244:Adenosine Diphosphate / Q000032:analysis; D000249:Adenosine Monophosphate / Q000032:analysis; D000255:Adenosine Triphosphate / Q000032:analysis; D000704:Analysis of Variance; D000818:Animals; D004734:Energy Metabolism / Q000187:drug effects; D006885:Hydroxybutyrates / Q000032:analysis; D007773:Lactates / Q000032:analysis; D008099:Liver / Q000032:analysis / Q000187:drug effects*; D008112:Liver Glycogen / Q000032:analysis; D008297:Male; D011773:Pyruvates / Q000032:analysis; D051381:Rats; D012771:Shock, Hemorrhagic / Q000503:physiopathology*; D013997:Time Factors; D014020:Tissue Extracts / Q000494:pharmacology*
D000090:Acetoacetates; D006885:Hydroxybutyrates; D007773:Lactates; D008112:Liver Glycogen; D011773:Pyruvates; D014020:Tissue Extracts; D000183:Actihaemyl; D000249:Adenosine Monophosphate; D000244:Adenosine Diphosphate; D000255:Adenosine Triphosphate
Biochemische Untersuchungen zur Wirkung eines eiweissfrein Hämoderivates auf die Erholungsfähigkeit der Rattenleber nach 60minütigem hämorrhagischem Schock