Effect of total cavo-portal shunt on pulmonary fibrin deposition after intra-aortal infusion of thrombin in the dog.
The effect of total cavo-portal shunt on the deposition of fibrin in the lungs and liver in dogs was studied after intra-aortal infusion of thrombin. 125I-labelled fibrinogen was used for calculation of the amount of fibrin. The pronounced pulmonary trapping of fibrin seen in non-operated control dogs did not occur in dogs submitted to the shunt operation; in these dogs a considerable trapping was seen in the liver. These results indicate that in generalized thrombinaemia the microclots are mainly formed in the venous circulation and transported to the nearest capillary network, where passive mechanical filtration occurs.
D000818:Animals; D001013:Aorta, Thoracic; D002404:Catheterization; D004285:Dogs; D005263:Femoral Artery; D005337:Fibrin / Q000378:metabolism*; D008099:Liver / Q000098:blood supply / Q000187:drug effects / Q000378:metabolism*; D008168:Lung / Q000187:drug effects / Q000378:metabolism*; D011167:Portacaval Shunt, Surgical; D011169:Portal Vein / Q000601:surgery; D013917:Thrombin / Q000008:administration & dosage / Q000494:pharmacology*; D014682:Vena Cava, Inferior / Q000601:surgery
D005337:Fibrin; D013917:Thrombin