Characterization of the collagen of human hypertrophic and normal scars.
The collagen produced in response to an injury of human skin is initially stabilized by a cross-link derived from hydroxyallysine, and characteristic of embryonic skin. In normal healing there is a change over with time to the cross-link derived from allysine, which is typical of young skin collagen. In contrast, hypertrophic scars fail to follow the time-related changes of normal skin, but retain the characteristics of embryonic collagen, indicating a continued rapid turnover of the collagen. This is further supported by the high proportion of the embryonic Type III collagen present in hypertrophic scars.
D000293:Adolescent; D000328:Adult; D000596:Amino Acids / Q000032:analysis; D002648:Child; D002921:Cicatrix / Q000473:pathology*; D003094:Collagen / Q000032:analysis*; D004549:Elastin / Q000032:analysis; D006801:Humans; D006901:Hydroxylysine / Q000032:analysis; D006984:Hypertrophy; D046911:Macromolecular Substances; D008875:Middle Aged; D011485:Protein Binding; D012867:Skin / Q000032:analysis*; D012995:Solubility; D013997:Time Factors; D014867:Water / Q000032:analysis
D000596:Amino Acids; D046911:Macromolecular Substances; D014867:Water; D006901:Hydroxylysine; D003094:Collagen; D004549:Elastin