Insulin antagonism of cortisol action on lechithin synthesis by cultured fetal lung cells.
In monolayer cel cultures from late gestation (28-day) rabbit fetal lungs, cortisol (5.5 X 10(-6)M) enhances lecithin synthesis and reduced cellular growth. The addition of insulin (25-100 muU/ml) abolishes the stimulatory effect of cortisol on lecithin synthesis but does not affect its growth-inhibiting activity.
D000818:Animals; D002478:Cells, Cultured; D005333:Fetus; D006854:Hydrocortisone / Q000037:antagonists & inhibitors* / Q000494:pharmacology; D007328:Insulin / Q000494:pharmacology*; D008168:Lung / Q000196:embryology; D010713:Phosphatidylcholines / Q000037:antagonists & inhibitors / Q000096:biosynthesis*; D011817:Rabbits
D007328:Insulin; D010713:Phosphatidylcholines; D006854:Hydrocortisone