Effects of insulin injection on responses of olfactory bulb and amygdala single units to odors.
The effect of insulin injection on transmission of neural activity within the olfactory system of the anesthetized male rat was investigated at the single unit level. It was found that insulin changed the response to odors of approximately 27% of olfactory bulb units and 21% of amygdala units tested. Many of the changes were in the direction of an increase in response magnitude, but there were some reversals in response direction and other complex changes. There was no evidence of a selective facilitation of responses to food odor as compared to non-food odors. Control observations of the response of thalamic somatosensory units to tactual stimulation showed no effects of insulin. These results suggest that hypothalamic hunger mechanisms may normally interact with olfactory mechanisms to augment and otherwise change the response of some olfactory system units to various odors.
D000679:Amygdala / Q000187:drug effects*; D000818:Animals; D001931:Brain Mapping; D007328:Insulin / Q000494:pharmacology*; D008297:Male; D009434:Neural Pathways; D009830:Olfactory Bulb / Q000187:drug effects*; D051381:Rats; D012903:Smell / Q000187:drug effects; D013787:Thalamic Nuclei / Q000187:drug effects
D007328:Insulin