Follow-up study of male and female offspring of DES-treated mothers a preliminary report.
This is a follow-up study of male and female offspring of mothers who were part of a double-blind placebo controlled investigation during the years 1951-1952, originally aimed at determining the usefulness of DES administration in maintaining pregnancy. So far, 84 DES-exposed females, 43 female controls, 42 DES-exposed males and 37 male controls have been examined. Circumferential ridges of the vagina and cervix were seen in 39% of the DES-exposed females but in none of the controls. Colposcopy revealed vaginal epitheleal changes in 78% of the DES-exposed females 2% of the female controls. Cytology proved to be reliable as a screening test for vaginal epithelial changes in the DES-exposed female. Urine cytology was negative for tumor cells in all patients. The main abnormal finding in the DES-exposed males was that cysts in the epididymis were detected in 10%. No cases of cancer were observed in either the male or female offspring.
D000014:Abnormalities, Drug-Induced; D000230:Adenocarcinoma / Q000139:chemically induced*; D000293:Adolescent; D000328:Adult; D001794:Blood Pressure / Q000187:drug effects; D004054:Diethylstilbestrol / Q000009:adverse effects*; D004822:Epididymis / Q000002:abnormalities; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008431:Maternal-Fetal Exchange; D008599:Menstruation Disturbances / Q000139:chemically induced; D010409:Penile Diseases / Q000139:chemically induced*; D011230:Precancerous Conditions / Q000139:chemically induced*; D011247:Pregnancy; D013733:Testicular Diseases / Q000139:chemically induced; D014625:Vaginal Neoplasms / Q000139:chemically induced*; D014646:Varicocele / Q000139:chemically induced
D004054:Diethylstilbestrol