Relationship of Plummer-Vinson disease to cancer of the upper alimentary tract in Sweden.
Sideropenic anemia with epithelial lesions (Plummer-Vinson syndrome) was previously very common among women in northern Sweden. The incidence of this condition is decreasing, however, because of better nutrition and improved health care. Plummer-Vinson syndrome as a sequela of previous sideropenic anemia still influences the pattern of hypopharyngeal and oral cancer in northern Sweden where the female/male ratio in these diseases is remarkably high and where cancer in the postcricoid part of the hypopharynx is relatively common. In Sweden as a whole, a decreasing trend in the incidence of hypopharyngeal cancer in women can be demonstrated, which is probably due to diminished prevalence of Plummer-Vinson syndrome.
D000328:Adult; D000368:Aged; D003680:Deglutition Disorders / Q000453:epidemiology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009062:Mouth Neoplasms / Q000453:epidemiology; D009747:Nutritional Physiological Phenomena; D010610:Pharyngeal Neoplasms / Q000453:epidemiology*; D011004:Plummer-Vinson Syndrome / Q000150:complications / Q000453:epidemiology*; D011230:Precancerous Conditions / Q000209:etiology; D012907:Smoking; D013548:Sweden