Modulation of uterine morphology and growth by estradiol-17beta and an estrogen antagonist.
The estrogen antagonist C1628 maintains sustained hypertrophy of the uterine epithelium and the synthesis of many proteins including peroxidase. C1628 is a progestogen, inducing secretion of the protein by surface epithelial and glandular cells. C1628 is a connective tissue mitogen, inducing DNA synthesis in fibroblasts and the endothelium. C1628 and estrogen share these properties mentioned above. Estrogen, however, induced moderate growth of the mucosa within a 24-h period and massive hyperplasia of the mucosa within a 24-h period thereafter. C1628 alone, or in combination with estradiol, does not have mitogenic effect on the mucosa, and in fact blocks the mitotic response normally induced by estrogen alone.
D000375:Aging; D000818:Animals; D000840:Anisoles / Q000494:pharmacology; D004847:Epithelial Cells; D004848:Epithelium / Q000502:physiology / Q000648:ultrastructure; D004958:Estradiol / Q000494:pharmacology*; D045166:Estradiol Congeners / Q000494:pharmacology; D004965:Estrogen Antagonists; D004971:Estrus / Q000187:drug effects; D005260:Female; D011247:Pregnancy; D011759:Pyrrolidines / Q000494:pharmacology*; D051381:Rats; D013343:Styrenes / Q000494:pharmacology; D013936:Thymidine / Q000378:metabolism; D013997:Time Factors; D014599:Uterus / Q000187:drug effects / Q000254:growth & development / Q000502:physiology* / Q000648:ultrastructure
D000840:Anisoles; D045166:Estradiol Congeners; D004965:Estrogen Antagonists; D011759:Pyrrolidines; D013343:Styrenes; D004958:Estradiol; D013936:Thymidine