Paramethadione and metabolite serum levels in humans after a single oral paramethadione dose.
A GLC method was developed to determine quantitatively paramethadione and its major metabolite, 5-ethyl-5-methyl-2,4-oxazolidinedione, in serum. The method was reproducible and sensitive to 0.2 mug/ml. After administering a single 300-mg oral dose to human subjects, the average paramethadione serum levels of 6.0 mug/ml occurred at 1 hr and decreased to 0.3 mug/ml after 48 hr. Metabolite serum levels gradually increased to 8.4 mug/ml at 32 hr and were still at this level at 48 hr, which was the last sampling point.
D000284:Administration, Oral; D000328:Adult; D002849:Chromatography, Gas; D006207:Half-Life; D006801:Humans; D008297:Male; D010080:Oxazoles / Q000008:administration & dosage / Q000097:blood*; D013997:Time Factors
D010080:Oxazoles; C005731:paramethadione