On the arrangement of histones in chromatin.
It was found that nucleoprotein particles formed after DNase I action on calf thymus chromatin contain single-stranded DNA fragments, associated with histones only by ionic linkages. These results suggest that histones in chromatin are bound ionically only to one polynucleotide strand of double-helical DNA, protecting it against nucleolytic attack.
D002843:Chromatin / Q000032:analysis* / Q000201:enzymology; D004277:DNA, Single-Stranded / Q000378:metabolism; D003851:Deoxyribonucleases / Q000378:metabolism; D006657:Histones / Q000032:analysis*
D002843:Chromatin; D004277:DNA, Single-Stranded; D006657:Histones; D003851:Deoxyribonucleases