The gamma-aminobutyric acid system in rat cerebellum during cannabinoid-induced cataleptoid state.
Repeated, but not single, intraperitoneal injections of delta1,6-tetrahydrocannabinol (delta1,6-THC) 20 mg/kg to rats administered daily for two weeks, produced increased gamma-aminobutyric acid (GABA) concentration and decreased glutamic acid decarboxylase (GAD) activity in the cerebellum, as well as enhancement of [3H]-GABA uptake by cerebellar crude synaptosomes. It seems that the motor impairment elicited by delta1,6-THC was not associated with the GABA system, but presumably might be related to changes in brain excitability.
D000613:Aminobutyrates / Q000378:metabolism*; D000818:Animals; D002188:Cannabis / Q000494:pharmacology*; D002375:Catalepsy / Q000139:chemically induced / Q000378:metabolism*; D002531:Cerebellum / Q000201:enzymology / Q000378:metabolism*; D013759:Dronabinol / Q000494:pharmacology*; D005260:Female; D005968:Glutamate Decarboxylase / Q000378:metabolism; D006801:Humans; D008297:Male; D009411:Nerve Endings / Q000378:metabolism; D051381:Rats; D005680:gamma-Aminobutyric Acid / Q000378:metabolism*
D000613:Aminobutyrates; D005680:gamma-Aminobutyric Acid; D013759:Dronabinol; D005968:Glutamate Decarboxylase