Comparison of bioavailability of two chloramphenicol preparations in dogs after intramuscular injection.
Aqueous chloramphenicol glycinate was compared with propylene glycol solution of chloramphenicol after equivalent intramuscular doses (22 mg/kg) were given to 10 normal, healthy dogs in a crossover study. Duration and magnitude of plasma concentrations of chloramphenicol were significantly longer and higher with the glycinate than with the propylene glycol solution.
D000818:Animals; D001682:Biological Availability; D002701:Chloramphenicol / Q000008:administration & dosage / Q000097:blood / Q000378:metabolism*; D004285:Dogs / Q000378:metabolism*; D005260:Female; D005998:Glycine; D007273:Injections, Intramuscular; D008297:Male; D011409:Propylene Glycols
D011409:Propylene Glycols; D002701:Chloramphenicol; D005998:Glycine