[The effect of N-nitrosomethylurea on organ cultures of human embryonal lung tissue].
The character of blastomogenic action of 7,12-dimethylbenz(a)anthracene on the stomach in its parenteral administration was studied on different lines of mice. Under the same conditions DMBA distribution was investigated in the proventriculus and gastric glandular tissues. In DMBA application on mice skin in the dosage of 0.5 mg per animal in 0.1 ml of acetone proventricular tumors developed in 34% of mice of line CC57Br, in 10% of mice of line CC57W, and in 11% of mice of line C3HA, and in 19% of white nonpedigree mice. In intraperitoneal injection of DMBA in the dose of 0.5 mg per mouse in 0.2 ml of saline solution proventricular tumors appeared in 56% of CC57Br mice (in 9 of 16) and in one of five mice of CC57W line. Whereas, in application of DMBA onto mice skin in the dose of 0.5 mg per mouse in 0.1 ml of acetone the DMBA content in the proventriculus was 13 times higher than that in gastric glandular tissues.
D005260:Female; D005315:Fetal Diseases / Q000139:chemically induced*; D006801:Humans; D006965:Hyperplasia / Q000139:chemically induced; D008168:Lung / Q000196:embryology; D008171:Lung Diseases / Q000139:chemically induced*; D008770:Methylnitrosourea / Q000633:toxicity*; D008938:Mitosis; D009336:Necrosis / Q000139:chemically induced; D009607:Nitrosourea Compounds / Q000633:toxicity*; D009924:Organ Culture Techniques; D009928:Organ Specificity; D011247:Pregnancy; D013997:Time Factors
D009607:Nitrosourea Compounds; D008770:Methylnitrosourea
Deístvie N-nitrozometilmocheviny na organye kul'tury émbrional'noí tkani cheloveka