The effects of ketamine and of Innovar anesthesia on digitalis tolerance in dogs.
In a comparison of digitalis tolerance in dogs anesthetized with ketamine, Innovar Vet, or pentobarbital, the dosage of ouabain needed to cause ventricular tachycardia was significantly higher, as was the LD50 of ouabain, with ketamine or Innovar than with pentobarbital. Ventricular tachycardia induced by ouabain was generally converted to sinus rhythm following administration of Innovar, ketamine, or droperidol but not after administration of fentayl alone or after pentobarbital.
D000769:Anesthesia, Inhalation; D000771:Anesthesia, Intravenous; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D004285:Dogs; D004329:Droperidol / Q000494:pharmacology*; D004338:Drug Combinations; D004347:Drug Interactions; D004361:Drug Tolerance; D005283:Fentanyl / Q000494:pharmacology*; D006352:Heart Ventricles / Q000187:drug effects; D007649:Ketamine / Q000494:pharmacology*; D007928:Lethal Dose 50; D010042:Ouabain / Q000008:administration & dosage / Q000494:pharmacology; D010424:Pentobarbital / Q000494:pharmacology; D013610:Tachycardia / Q000139:chemically induced
D004338:Drug Combinations; D010042:Ouabain; D007649:Ketamine; D010424:Pentobarbital; D004329:Droperidol; D005283:Fentanyl