Differential accumulation of virus-specific RNA during the cell cycle of adenovirus-transformed rat embyro cells.
In adenovirus type 2-transformed rat embryo cells there is a threefold greater incorporation of [3-H]uridine into virus-specific RNA early in S phase than in late S or G2. This heightened accumulation of labeled RNA is true for both nuclear and cytoplasmic virus-specific labeling. Inhibition of DNA synthesis decreases the virus-specific RNA labeling, whereas reversal of inhibition again allows the elevated level of virus-specific RNA labeling.
D000256:Adenoviridae; D000818:Animals; D002455:Cell Division; D002467:Cell Nucleus / Q000378:metabolism; D002471:Cell Transformation, Neoplastic; D002478:Cells, Cultured / Q000187:drug effects / Q000378:metabolism; D003593:Cytoplasm / Q000378:metabolism; D006918:Hydroxyurea / Q000494:pharmacology; D012367:RNA, Viral / Q000096:biosynthesis*; D051381:Rats / Q000196:embryology; D014316:Tritium; D014529:Uridine
D012367:RNA, Viral; D014316:Tritium; D014529:Uridine; D006918:Hydroxyurea