Dissociation of field potential from neuronal activity in the isolated retina: failure of the b-wave with normal ganglion cell response.
The b-wave of the isolated rabbit retina was compared with the ganglion cell response to light before and after modification of the retina's incubating medium. Marked diminution of the b-wave, with no reduction in ganglion cell response, was observed under three experimental conditions: (1) following a short period of anoxia; (2) following a short period in 0.2 mM Ca++; (3) in a small percentage of preparations, simply as a result of prolonged incubation in control medium. In contrast, a short period in 50 mM K+ led to a parallel fall and parallel recovery of both responses. It is apparent that under selected conditions the field potentials which constitute the b-wave are poorly correlated with the retina's neural activity.
D000818:Animals; D002118:Calcium / Q000494:pharmacology; D004596:Electroretinography; D000860:Hypoxia / Q000503:physiopathology; D066298:In Vitro Techniques; D008027:Light; D009474:Neurons / Q000502:physiology; D011188:Potassium / Q000494:pharmacology; D011817:Rabbits; D012160:Retina / Q000502:physiology* / Q000503:physiopathology
D011188:Potassium; D002118:Calcium