The effect of dietary protein levels on the rate of lipid biosynthesis from glycerol-3-phosphate in rat liver.
The effect of dietary protein levels on the rate of lipid synthesis from glycerol-3-phosphate was studied in the rat. Optimal conditions for studying this metabolic reaction were established by measuring the entry of sn-14C-glycerol-3-phosphate into lipid in vitro. The rate of glycerol-3-phosphate incorporation into lipid in animals fed a 10 percent protein diet for 6 days was significantly less than for those given diets containing 20 or 30 percent protein while the converse was true after 26 days. The results indicate that the response of this particular metabolic step in lipid formation to dietary protein should be considered when attempting to explain the influence of dietary protein on lipid concentration in various tissues.
D000818:Animals; D004044:Dietary Proteins / Q000378:metabolism*; D005994:Glycerophosphates / Q000378:metabolism*; D008055:Lipids / Q000096:biosynthesis*; D008099:Liver / Q000378:metabolism*; D008297:Male; D051381:Rats; D013268:Stimulation, Chemical; D013997:Time Factors
D004044:Dietary Proteins; D005994:Glycerophosphates; D008055:Lipids