Postreplication repair of DNA in UV-irradiated mammalian cells.
Some current controversies concerning the mechanism of postreplication repair in mammalian cells are discussed. We have found that two xeroderma pigmentosum cell lines normal in excision-repair are abnormal in postreplication repair. The rate of postreplication repair is slower than that in normal cells and is caffeine sensitive. In normal human fibroblasts, caffeine has little effect.
D001665:Binding Sites; D002460:Cell Line; D004247:DNA / Q000096:biosynthesis; D004260:DNA Repair / Q000528:radiation effects*; D006801:Humans; D011742:Pyrimidine Nucleotides / Q000378:metabolism; D011830:Radiation Effects; D013698:Templates, Genetic; D014466:Ultraviolet Rays; D014983:Xeroderma Pigmentosum / Q000378:metabolism
D011742:Pyrimidine Nucleotides; D004247:DNA