Grisorixin, an ionophorous antibiotic of the nigericin group. II. Chemical and structural study of grisorixin and some derivatives.
Grisorixin, a polycyclic polyether antibiotic of the nigericin group, showed ionophorous properties. The conformations of crystallized grisorixin and its metallic salts are very similar and are compared in this paper. The physico-chemical properties of the salts are described. The chemical oxidation of grisorixin methyl ester allowed us to isolate several oxidation products whose structures are described.
D000107:Acetylation; D000900:Anti-Bacterial Agents; D002414:Cations, Monovalent; D055598:Chemical Phenomena; D002621:Chemistry; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D008968:Molecular Conformation; D009550:Nigericin / Q000031:analogs & derivatives / Q000032:analysis; D010084:Oxidation-Reduction
D000900:Anti-Bacterial Agents; D002414:Cations, Monovalent; D009550:Nigericin