[Effect of terodiline on bronchial muscles and on tracheobronchial clearance in the rat].
Effects of 1-methyl-3,3-diphenyl-1N-tert.-butyl-propylamine-hydrochloride (terodilin, Bicor) on bronchial muscle and mucociliary function was studie in isolated airways preparations of rats. Terodilin blocked the bronchoconstrictor effect of acetylcholine but was ineffective against that caused by serotonin and bradykinin. The alteration of the dose-respone curves of acetylcholine by terodilin indicated that terodilin is a partial agonist of acetylcholine with a very small intrinsic activity. This finding may explain the ciliostimulatory effect of this drug.
D000109:Acetylcholine / Q000037:antagonists & inhibitors / Q000494:pharmacology; D000403:Airway Resistance / Q000187:drug effects; D000818:Animals; D001920:Bradykinin / Q000494:pharmacology; D001980:Bronchi / Q000187:drug effects*; D002082:Butylamines / Q000494:pharmacology*; D004347:Drug Interactions; D005260:Female; D009092:Mucous Membrane / Q000187:drug effects; D009129:Muscle Tonus / Q000187:drug effects; D009130:Muscle, Smooth / Q000187:drug effects*; D051381:Rats; D012701:Serotonin / Q000494:pharmacology; D014132:Trachea / Q000187:drug effects*
D002082:Butylamines; D012701:Serotonin; D000109:Acetylcholine; D001920:Bradykinin
Wirkung von terodilin auf die Bronchialmuskulatur und die tracheobronchiale Reinigung der Ratte