[The effects of imolamine on auriculo-ventricular conduction by recoil of His potential].
The electropharmacological action of imolamine was studied using Hiss bundle electrography.  In dogs with spontaneous sinusal rhythm, imolamine decreases Hiss-Purkinje and total intraventricular conduction, without affecting auriculoventricular conduction time. In dogs with paced sinusal rhythm (180/min), imolamine increases atrial and ventricular thresholds and atrial refractory period, and decreases intra-atrial and intraventricular conduction; no significant modification of auriculoventricular conduction was noted at therapeutic dosages. In ouabaïn-intoxicated dogs, imolamine suppresses digitalis rhythm disorders and antagonizes the action of the glycoside on A-V node, as does diphenylhydantoïne, but, in contrast to this drug, it increases slightly intraventricular conductivity.
D000818:Animals; D001283:Atrioventricular Node / Q000502:physiology; D002036:Bundle of His / Q000502:physiology; D004048:Diethylamines / Q000494:pharmacology; D004285:Dogs; D004562:Electrocardiography; D005071:Evoked Potentials / Q000187:drug effects*; D005260:Female; D006329:Heart Conduction System / Q000187:drug effects*; D006339:Heart Rate / Q000187:drug effects; D008297:Male; D010042:Ouabain / Q000037:antagonists & inhibitors; D010069:Oxadiazoles / Q000494:pharmacology*; D010672:Phenytoin / Q000494:pharmacology; D011690:Purkinje Fibers / Q000502:physiology; D012033:Refractory Period, Psychological / Q000187:drug effects; D013997:Time Factors
D004048:Diethylamines; D010069:Oxadiazoles; D010042:Ouabain; D010672:Phenytoin; C002787:imolamine
Etude des effets de l'lmolamine sur la conduction aurticulo-ventriculaire par recuell du potentiel Hissien