Spermatogenic arrest produced in the adult male rat by 19-norspiroxenone, a potent anti-estrogen.
19-Norspiroxenone, a potent anti-estrogen with no known estrogenic action, produces a striking arrest of spermatogenesis in the early stages of meiosis in the adult male rat with a complete block of fertility.
D000818:Animals; D000988:Antispermatogenic Agents; D003864:Depression, Chemical; D004963:Estrenes / Q000494:pharmacology*; D004965:Estrogen Antagonists; D005663:Furans / Q000494:pharmacology*; D008297:Male; D051381:Rats; D013091:Spermatogenesis / Q000187:drug effects*; D013737:Testis / Q000187:drug effects
D000988:Antispermatogenic Agents; D004963:Estrenes; D004965:Estrogen Antagonists; D005663:Furans; C011318:19-norspiroxenone