The penetration of dapsone, rifampicin, isoniazid and pyrazinamide into peripheral nerves.
1 Dapsone, rifampicin, isoniazid and pyrazinamide were shown to penetrate readily into the sciatic nerves of the dog and sheep. 2 These findings suggest that the continued persistence of viable drug-sensitive leprosy bacilli in the peripheral nerves of patients treated for long periods with either dapsone or rifampicin is not due to inadequate intraneural drug penetration.
D000818:Animals; D003622:Dapsone / Q000378:metabolism*; D004285:Dogs; D007538:Isoniazid / Q000378:metabolism*; D010525:Peripheral Nerves / Q000378:metabolism*; D011718:Pyrazinamide / Q000378:metabolism*; D012293:Rifampin / Q000378:metabolism*; D012584:Sciatic Nerve / Q000378:metabolism; D012756:Sheep; D013997:Time Factors
D011718:Pyrazinamide; D003622:Dapsone; D007538:Isoniazid; D012293:Rifampin