Metabolic studies on metiazinic acid I. Absorption, distribution, excretion and metabolism in rats and rabbits.
Absorption, distribution, excretion and metabolism after oral administration of 3-H-labelled metiazinic acid were studied. The administered radioactivity was excreted through both the urinary and fecal routes. The maximum levels of concentration in blood and most tissues were shown with 3 hr after dosing. The highest radioactivity was found in the kidney throughout all experiments. Relatively high radioactivity was observed in inflammatory-treated parts in rats. Unchanged compound, metiazinic acid S-oxide and these conjugates were found in urine and feces. Approximately 60% of the unchanged form was observed in plasma after 6 hr.
D000818:Animals; D001345:Autoradiography; D001646:Bile / Q000378:metabolism; D002855:Chromatography, Thin Layer; D004487:Edema / Q000378:metabolism; D004890:Erythema / Q000378:metabolism; D005243:Feces / Q000032:analysis; D007408:Intestinal Absorption; D007700:Kinetics; D008297:Male; D010640:Phenothiazines / Q000378:metabolism*; D011817:Rabbits; D051381:Rats
D010640:Phenothiazines