[Experimental exophthalmos. Preliminary communication].
Pyrogallol and N1-(d,1-seryl)-N2-(2,3,4-trihydroxy-benzyl)-hydrazine (RO-4-4602), two inhibitors of catechol-O-methyl-transferase, produce exophthalmus in mice and rats. This exophthalmus can be suppressed by local application of guanethidine.
D000818:Animals; D001545:Benserazide / Q000494:pharmacology*; D005094:Exophthalmos / Q000139:chemically induced* / Q000188:drug therapy; D005260:Female; D006145:Guanethidine / Q000627:therapeutic use; D006834:Hydrazines / Q000494:pharmacology*; D008297:Male; D051379:Mice; D011748:Pyrogallol / Q000494:pharmacology*; D051381:Rats; D013972:Thyrotropin / Q000627:therapeutic use; D013997:Time Factors
D006834:Hydrazines; D011748:Pyrogallol; D001545:Benserazide; D013972:Thyrotropin; D006145:Guanethidine
Experimenteller Exophthalmus. Vorläufige Mitteilung