Adenovirus and ileocecal intussusception.
Intranuclear inclusion bodies were found by light microscopy in epithelial cells in more than one-third of the specimens from children operated on for ileocecal intussusception. Electron microscopic examination done on hematoxylin and eosin-stained slides showed the intranuclear inclusion bodies to be composed of viral particles in large and small crystalline arrays. Adenovirus of serotypes 2, 3, and 5 were isolated from the five cases with inclusions in which isolation was attempted. These findings strongly suggest a pathogenetic role for adenovirus in those cases of intussusception in which intranuclear inclusion bodies are found in the epithelial cells of the appendix or the terminal ileum.
D000256:Adenoviridae / Q000302:isolation & purification*; D001065:Appendix / Q000473:pathology; D002432:Cecum / Q000382:microbiology*; D002467:Cell Nucleus / Q000648:ultrastructure; D002675:Child, Preschool; D004847:Epithelial Cells; D004848:Epithelium / Q000648:ultrastructure; D005260:Female; D006801:Humans; D007082:Ileum / Q000382:microbiology* / Q000473:pathology; D007181:Inclusion Bodies, Viral; D007223:Infant; D007413:Intestinal Mucosa / Q000648:ultrastructure; D007443:Intussusception / Q000382:microbiology* / Q000473:pathology; D008297:Male