The action of gantrisin [N'-(3,4-dimethyl-5-isoxazolyl)sulfanilamide] on the oedema-forming and muscle-stimulating activity of eledoisin and physalaemin.
The effects of gantrisin on oedema-forming and muscle-stimulating activity of eledoisin and physalaemin were studied. Both in vivo and in vitro the sulfanilamide caused a dose-dependent inhibition of the peptides' effects. The antagonism appeared to be of the non competitive as well as of the non specific type.
D000818:Animals; D002199:Capillary Permeability / Q000187:drug effects; D003106:Colon / Q000187:drug effects; D004487:Edema / Q000139:chemically induced*; D004600:Eledoisin / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D006168:Guinea Pigs; D006632:Histamine / Q000494:pharmacology; D007082:Ileum / Q000187:drug effects; D066298:In Vitro Techniques; D009119:Muscle Contraction / Q000187:drug effects; D009130:Muscle, Smooth / Q000187:drug effects*; D010455:Peptides / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D011817:Rabbits; D012867:Skin / Q000098:blood supply; D013268:Stimulation, Chemical; D013444:Sulfisoxazole / Q000494:pharmacology*
D010455:Peptides; D004600:Eledoisin; D013444:Sulfisoxazole; D006632:Histamine