Interference of spironolactone in 11-doexycorticosterone radioassays.
Uniformly elevated plasma 11-deoxycorticosterone (DOC) values are obtained in patients receiving spironolactone. This elevation is shown to be spurious, and is a result of cross-interference of spironolactine and its metabolite, canrenone, in both the DOC radioimmunoassay and competitive protein-binding radioassay.
D003900:Desoxycorticosterone / Q000097:blood* / Q000276:immunology; D005069:Evaluation Studies as Topic; D005189:False Positive Reactions; D006801:Humans; D006973:Hypertension / Q000097:blood; D008297:Male; D011863:Radioimmunoassay / Q000379:methods; D011869:Radioligand Assay / Q000379:methods; D013148:Spironolactone / Q000097:blood*
D013148:Spironolactone; D003900:Desoxycorticosterone