D-norgestrel slow-releasing T device as an intrauterine contraceptive.
A D-norgestrel slow-releasing T device was tried as an IUD in 100 fertile multiparous women for 6 months. The preliminary results were very encouraging. Not a single case of unintended pregnancy or removal due to excessive pain and bleeding was reported. The menstrual patterns and amounts of blood loss during menses did not reveal any marked variations. 3-H-D-norgestrel was used to study the in vitro release rate of D-norgestrel. The in vivo release rate was studied with the use of horseshoe-shaped silicone rubber capsules loaded with D-norgestrel as a temporary device. The uptake of intrauterine H-D-norgestrel in the circulation and genital tissues was estimated in two women.
D005260:Female; D005836:Genitalia, Female / Q000187:drug effects / Q000378:metabolism; D006801:Humans; D007434:Intrauterine Devices; D007436:Intrauterine Devices, Medicated; D008598:Menstruation / Q000187:drug effects; D009644:Norgestrel / Q000097:blood / Q000378:metabolism / Q000494:pharmacology*
D009644:Norgestrel