Reye syndrome with associated influenza A and B infection.
In early 1974, seventeen children were treated for Reye syndrome. Thirteen of these were studied for laboratory evidence of concomitant viral infection. Influenza B/Hong Kong was isolated from the pharynx in four of nine 1974 cases tested. One child had just recovered from varicella. Adenovirus type 2 and respiratory syncytial virus were isolated from two additional patients. Serologic tests for influenza suggested concomitant or recent influenza B infection in ten of 13 of 1971 cases. During February 1975, six children were treated for this syndrome. Influenza A/Port Chalmers was recovered from three in six 1975 cases, and all six showed significant antibody rises to influenza A. These studies suggest that influenza viruses provide a trigger mechanism for the development of Reye syndrome in susceptible children.
D000256:Adenoviridae / Q000302:isolation & purification; D000293:Adolescent; D000914:Antibodies, Viral / Q000032:analysis; D001927:Brain Diseases / Q000209:etiology*; D002648:Child; D002675:Child, Preschool; D004196:Disease Outbreaks / Q000453:epidemiology; D004198:Disease Susceptibility; D005260:Female; D006801:Humans; D007223:Infant; D007251:Influenza, Human / Q000150:complications*; D008297:Male; D009975:Orthomyxoviridae / Q000302:isolation & purification*; D010414:Pennsylvania; D010614:Pharynx / Q000382:microbiology; D012202:Reye Syndrome / Q000209:etiology*
D000914:Antibodies, Viral