Investigation of some materials as dry binders for direct compression in tablet manufacture. Part 7: Formulation and evaluation of ascorbic acid and phenobarbitone tablets.
Directly compressible powder blends containing either ascorbic acid or phenobarbitone, and utilizing tragacanth, Carbowax 4000, Plasdone, and mannitol as dry binders, were formulated. The flowability of the powder mixes prior to compression was determined. Furthermore, the tablets prepared according to the suggested formulae were tested for hardness, friability, uniformity of weight, distribution of active ingredient, disintegration, and dissolution. The effect of aging on the qualities of the tablets was also studied.
D001205:Ascorbic Acid; D002626:Chemistry, Pharmaceutical; D004339:Drug Compounding; D004355:Drug Stability; D004356:Drug Storage; D006244:Hardness; D010592:Pharmaceutic Aids; D010634:Phenobarbital; D011092:Polyethylene Glycols; D011134:Polysaccharides; D011205:Povidone; D011208:Powders; D011786:Quality Control; D012212:Rheology; D012828:Silicones; D013607:Tablets; D013627:Talc; D013997:Time Factors
D010592:Pharmaceutic Aids; D011134:Polysaccharides; D011208:Powders; D012828:Silicones; D013607:Tablets; D013627:Talc; D011092:Polyethylene Glycols; D011205:Povidone; D001205:Ascorbic Acid; D010634:Phenobarbital