Anti-inflammatory action of glucagon in rats.
1 Subcutaneous administration of glucagon (1 and 0.5 mg/kg) 30 min before the injection of carrageenin or dextran into the rat's paw reduced oedema and the local exudation of Evans blue previously given intravenously. 2 The effect persisted after removal of the adrenal medulla but not after adrenalectomy. 3 When glucagon (1 mg/kg, s.c.) was given daily after a local reaction to Freund's adjuvant injected into the paw had developed, a decrease in the reaction was observed up to 12 days. Blood sugar levels remained within the normal range. 4 Glucagon may exert an anti-inflammatory effect through the release of adrenal corticosteroids and thus help modulate inflammatory reactions.
D000311:Adrenal Glands / Q000502:physiology; D000313:Adrenal Medulla / Q000502:physiology; D000315:Adrenalectomy; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use*; D001786:Blood Glucose / Q000378:metabolism; D002351:Carrageenan; D003911:Dextrans; D004487:Edema / Q000139:chemically induced / Q000188:drug therapy; D005934:Glucagon / Q000627:therapeutic use*; D008297:Male; D010477:Perfusion; D051381:Rats; D013997:Time Factors
D000893:Anti-Inflammatory Agents; D001786:Blood Glucose; D003911:Dextrans; D002351:Carrageenan; D005934:Glucagon