Effects of retinoic acid on prostaglandin biosynthesis in guinea-pig skin.
Topical application of retinoic acid on guinea-pig skin resulted within 70 hours in erythema with a concomitant elevation of endogenous prostaglandin E2 (PGE2) in the treated areas of the skin. Prolonged daily treatment resulted in the development of severe scaly dermatoses and a corresponding decrease in the level of PGE2 in the skin. Examination of retinoic acid effects on the in vitro biosynthesis of PGE2 from arachidonic acid by extracts from guinea-pig skin and sheep vesicular gland demonstrated that retinoic acid inhibits prostaglandin synthesis in a concentration and time-dependent manner. These results indicate that retinoic acid may exert a regulatory role on prostaglandin biosynthesis in the skin.
D000818:Animals; D006168:Guinea Pigs; D066298:In Vitro Techniques; D011458:Prostaglandins E / Q000096:biosynthesis*; D012867:Skin / Q000187:drug effects*; D014212:Tretinoin / Q000494:pharmacology*; D014801:Vitamin A / Q000031:analogs & derivatives*
D011458:Prostaglandins E; D014801:Vitamin A; D014212:Tretinoin