Effects of supply and withdrawal of fluoride. Experimental studies on growing and adult rabbits. 8. Phosphatase activity in fluorotic bone.
Growing rabbits were given 200 ppm of fluoride in the drinking water during 14 weeks. During this period excessive fluorotic changes developed in the diaphyses of the femur and tibia. The alkaline phosphatase and pyrophosphatase activities increased simultaneously in the fluorotic bone whereas the ratio between the activities remained constant. Acid phosphatase activity also increased. The increase in enzyme activities was regarded as due to the increased bone turnover and not as a primary consequence of fluoride ingestion.
D000135:Acid Phosphatase / Q000378:metabolism*; D000469:Alkaline Phosphatase / Q000378:metabolism*; D000818:Animals; D001842:Bone and Bones / Q000201:enzymology*; D005260:Female; D005269:Femur / Q000000981:diagnostic imaging / Q000201:enzymology; D005459:Fluorides / Q000494:pharmacology*; D008297:Male; D011755:Pyrophosphatases / Q000378:metabolism*; D011817:Rabbits; D011859:Radiography; D013268:Stimulation, Chemical; D013977:Tibia / Q000000981:diagnostic imaging / Q000201:enzymology
D000469:Alkaline Phosphatase; D000135:Acid Phosphatase; D011755:Pyrophosphatases; D005459:Fluorides