Snuff dippers keratosis (snuff-induced leukoplakia).
Patients with chronic snuff-induced keratosis associated with mucosal ulcerations were treated with topically applied vitamin A acid. In each case, after a marked, local inflammatory response initially, topical vitamin A acid showed a definite beneficial effect in promoting healing and involution of the precancerous snuff-induced leukoplakic keratosis. In one patient there was distinct involution of the oral lesions with complete healing and restoration of a normal-appearing mucosa within five weeks after beginning of treatment. In four patients there was healing of superficial ulcerations and regression in the size of the luekoplakic lesions.
D000368:Aged; D002610:Cheek; D002908:Chronic Disease; D005260:Female; D006801:Humans; D007972:Leukoplakia, Oral / Q000139:chemically induced* / Q000188:drug therapy / Q000473:pathology / Q000601:surgery; D008297:Male; D008875:Middle Aged; D009061:Mouth Mucosa / Q000187:drug effects; D014030:Tobacco, Smokeless; D014801:Vitamin A / Q000627:therapeutic use
D014801:Vitamin A