[Comparative study of the fate of fluorofur and 5-fluorouracil in the organism].
Fluorofur (FT) is slowly splitted in tissues releasing free 5-FU. The duration of stay in the organism of 5-FU formed from FT is longer than that of 5-FU administered solely. Moreover, FT does not result in the formation of such high 5-FU concentrations, as observed while using 5-FU itself. It seems to account for an insignificant toxicity of FT and its greater efficacy in treatment of malignant tumors.
D000818:Animals; D001921:Brain / Q000378:metabolism; D005472:Fluorouracil / Q000031:analogs & derivatives* / Q000097:blood / Q000378:metabolism*; D005663:Furans / Q000378:metabolism; D005753:Gastric Mucosa / Q000378:metabolism; D007420:Intestine, Large / Q000378:metabolism; D007421:Intestine, Small / Q000378:metabolism; D007668:Kidney / Q000378:metabolism; D008168:Lung / Q000378:metabolism; D008297:Male; D009132:Muscles / Q000378:metabolism; D009206:Myocardium / Q000378:metabolism; D051381:Rats; D013154:Spleen / Q000378:metabolism; D013950:Thymus Gland / Q000378:metabolism; D013997:Time Factors
D005663:Furans; D005472:Fluorouracil
Sravnitel'noe izuchenie sud'by ftorafura i 5-ftoruratsila v organizme