Morphological changes after simultaneous administration of isoproterenol (ISO) and K+,MG2+-Aspartate (KMg-ASP) as a physiological Ca2+ antagonist.
Calcium antagonistic compounds including physiological ions of K and Mg are supposed to protect the heart against the deleterious effect of calcium overload. Pretreatment with K,Mg-aspartate in a single i.v. dose of 100 mg/kg was performed in dogs 5--10 min prior to isoproterenol chloride injection in a single dose of 7 mg/kh s.c. Administration of K,Mg-aspartate alone in the above-mentioned dose produced reversible changes of mitochondria after 2--6 hr. K,Mg-aspartate pretreatment applied prior to isoproterenol application revealed summarization of both K,Mg-aspartate and isoproterenol-produced changes after 2--6 h without significantly preventing hypoxic-like alterations. However, the final result after 24 h was good improvement of ultrastructure generally resembling metabolic regeneration and/or enhanced metabolic activity.
D000818:Animals; D001224:Aspartic Acid / Q000031:analogs & derivatives* / Q000494:pharmacology; D002118:Calcium / Q000037:antagonists & inhibitors*; D004285:Dogs; D005110:Extracellular Space / Q000648:ultrastructure; D006003:Glycogen / Q000032:analysis; D006651:Histocytochemistry; D007545:Isoproterenol / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D008055:Lipids / Q000032:analysis; D008274:Magnesium / Q000494:pharmacology; D008297:Male; D008931:Mitochondria, Muscle / Q000648:ultrastructure; D009203:Myocardial Infarction / Q000139:chemically induced* / Q000473:pathology; D009336:Necrosis / Q000139:chemically induced; D011188:Potassium / Q000494:pharmacology; D012519:Sarcoplasmic Reticulum / Q000648:ultrastructure
D008055:Lipids; D001224:Aspartic Acid; D006003:Glycogen; D008274:Magnesium; D007545:Isoproterenol; D011188:Potassium; D002118:Calcium