Inhibitory effects of pre- and posttest drugs on mouse-killing by rats.
Mouse-killing in rats was gradually inhibited by repeated posttest injections of d-amphetamine (1.5 mg/kg), l-amphetamine (1.5 mg/kg) or pilocarpine (7.5 mg/kg), but not by control substances. Of these drugs, only d-amphetamine inhibited killing when given prior to a mouse-killing test. Further experiments suggested that anorexia per se did not contribute to drug-induced inhibitory effects, but that changes in internal state were important to the development of inhibition. Pretest injections appear to inhibit predatory killing by a direct pharmacological action on some target site or sites, while posttest injections produce a learned aversion to predatory killing.
D000374:Aggression / Q000187:drug effects*; D000661:Amphetamine / Q000494:pharmacology*; D000818:Animals; D003913:Dextroamphetamine / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D005247:Feeding Behavior / Q000187:drug effects; D006801:Humans; D008297:Male; D051379:Mice; D010862:Pilocarpine / Q000494:pharmacology*; D051381:Rats; D013997:Time Factors
D010862:Pilocarpine; D000661:Amphetamine; D003913:Dextroamphetamine