Diurnal variations in radiosensitivity of mouse intestine.
Crypts in the mouse small intestine show a diurnal rhythm in radiosensitivity and are most sensitive in the middle of the dark period, when mitotic activity in the crypt is high. Analysis of crypt survival on a cellular basis shows that the changes in cryptogenic cell radiosensitivity are dose-modifying between 1,000 and 1,450 rads gamma rays such that the DO value varies between 85 rads and 140 rads.
D000818:Animals; D002470:Cell Survival / Q000528:radiation effects; D002940:Circadian Rhythm; D004307:Dose-Response Relationship, Radiation; D005260:Female; D007413:Intestinal Mucosa / Q000166:cytology / Q000528:radiation effects*; D007421:Intestine, Small / Q000528:radiation effects; D007422:Intestines / Q000528:radiation effects*; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D008811:Mice, Inbred DBA; D008938:Mitosis; D011830:Radiation Effects