Inhibition of dopamine-beta-hydroxylase by carnosine.
Dopamine-beta-hydroxylase was partially purified from bovine adrenal medulla and the effect of carnosine on the dopamine-beta-hydroxylase activity was investigated. Carnosine significantly inhibited the enzyme activity at the concentrations higher than 0.5 mM. According to the Lineweaver-Burk plots, the inhibition observed appeared to be a non-competitive type with the substrate, tyramine.
D000818:Animals; D002336:Carnosine / Q000494:pharmacology*; D002417:Cattle; D004151:Dipeptides / Q000494:pharmacology*; D004299:Dopamine beta-Hydroxylase / Q000037:antagonists & inhibitors*
D004151:Dipeptides; D002336:Carnosine; D004299:Dopamine beta-Hydroxylase