Altering iodine metabolism in the calf by feeding iodine-binding agents.
Effects of feeding cottonseed meal and anion-exchange resin on iodine absorption and excretion by calves were investigated. Each additional amount of resin fed from .3 to 3.5 g/kg body weight further increased fecal excretion from single oral iodine-131 and intravenous iodine-125 doses. By feeding 3 to 10 g cottonseed meal/kg body weight, excretion of oral iodine-131 given daily was increased 7 to 94% in feces and reduced as much as 35% in urine, but plasma iodine-131 was not changed. Introducing 1 g resin/kg body weight daily into the diet increased fecal iodine-131 excretion three to five times that with cottonseed meal alone and reduced both plasma and urinary iodine-131. The same amount of resin fed daily had similar effects on excretion of iodine-131 injected subcutaneously each day. Although iodine depletion by a highly efficient iodine binder (resin) in the gastrointestinal tract is probable, iodine binding by a natural feed constituent (cottonseed meal) was relatively inefficient.
D000284:Administration, Oral; D000818:Animals; D000837:Anion Exchange Resins / Q000494:pharmacology*; D002417:Cattle / Q000378:metabolism*; D003369:Cottonseed Oil / Q000494:pharmacology*; D004064:Digestive System / Q000378:metabolism; D004305:Dose-Response Relationship, Drug; D005243:Feces / Q000032:analysis; D007275:Injections, Intravenous; D007279:Injections, Subcutaneous; D007455:Iodine / Q000378:metabolism*; D007457:Iodine Radioisotopes / Q000008:administration & dosage; D007475:Ion Exchange Resins / Q000494:pharmacology*
D000837:Anion Exchange Resins; D003369:Cottonseed Oil; D007457:Iodine Radioisotopes; D007475:Ion Exchange Resins; D007455:Iodine