[Influence of hypothyroidism on the lacticodehydrogenase isoenzymes during the cerebral cortex maturation in the rat].
The isoenzymes of lacticdehydrogenase of cerebral cortex, investigated by starch gel electrophoresis, are changed during pre and neonatal thyroidectomies in relation to these factors: a) dose of the drug (131I or Propylthiouracil), b) date of gestation, c) the age of the animal (with a maximal modification at the 17th-18th day). They retain an enzymatic pattern like the fetal pattern, showing the retardation of the developing central nervous system.
D000367:Age Factors; D000818:Animals; D000831:Animals, Newborn; D002540:Cerebral Cortex / Q000196:embryology / Q000201:enzymology / Q000254:growth & development*; D004592:Electrophoresis, Starch Gel; D005260:Female; D007037:Hypothyroidism / Q000201:enzymology*; D007457:Iodine Radioisotopes; D007527:Isoenzymes; D007770:L-Lactate Dehydrogenase / Q000378:metabolism*; D008297:Male; D011441:Propylthiouracil / Q000008:administration & dosage; D051381:Rats; D013961:Thyroid Gland / Q000502:physiology*; D013965:Thyroidectomy
D007457:Iodine Radioisotopes; D007527:Isoenzymes; D011441:Propylthiouracil; D007770:L-Lactate Dehydrogenase
Influence de l'hypothyroidie sur les isoenzymes de la lacticodehydrogenase au cours de la maturation du cortex cérébral chez le rat