[Study on the effect of insulin on carbohydrate and lipid metabolism in obese subjects with normal glucose tolerance].
In altogether 32 test persons with normal weight and obese test persons glucose-insulin-tolerance-tests were carried out. In obese persons with normal carbohydrate tolerance -- characterized by 50 g oral glucose tolerance test -- by the decreased glucose assimilation coefficients and the significantly increased level of glycaemia after intravenous application of glucose a disturbance of the glucose-insulin-homoeostasis is already implied. Basal and glucose-stimulated concentrations of IRI in the peripheral venous blood were significantly increased in obese persons. The parameters of lipolysis glycerol and free fatty acids show after a glucose-stimulated insulin excretion and after exogenic insulin application a somewhat retarded decrease in obese persons compared with the control group. In connection with the significantly increased insulin levels in obese persons these findings might refer to a decreased antilipolytic effect of insulin. The two fundamental physiological effects of insulin in the carbohydrate and fat metabolism -- glucose utilization and inhibition of lipolysis -- seem to be distrubed in the same way in obesity.
D000328:Adult; D000917:Antibody Formation; D000941:Antigens; D001786:Blood Glucose / Q000378:metabolism; D001835:Body Weight; D002241:Carbohydrates / Q000097:blood*; D004734:Energy Metabolism / Q000187:drug effects; D005260:Female; D005951:Glucose Tolerance Test; D005990:Glycerol / Q000097:blood; D006801:Humans; D007328:Insulin / Q000097:blood / Q000494:pharmacology*; D008055:Lipids / Q000097:blood*; D008297:Male; D009765:Obesity / Q000097:blood* / Q000175:diagnosis / Q000276:immunology
D000941:Antigens; D001786:Blood Glucose; D002241:Carbohydrates; D007328:Insulin; D008055:Lipids; D005990:Glycerol
Untersuchung zur Insulinwirkung auf den Kohlenhydrat- und Fettstoffwechsel bei Fettsüchtigen mit normaler Glukosetoleranz