[Comparison of the antiarrhythmic effects of PGA1, PGA2, PGE1, PGE2 and PGF2 alpha on a barium chloride arrhythmia model in unanesthetized rabbits].
Experimental studies on BaCl2 induced arrhythmias in unanaesthetized rabbits showed an antiarrhythmic effect of prostaglandins A1, A2, E1, E2 and F2a by infusions of 0,1 to 6,0 mug/kg/min over 3 min. There was a maximum antiarrhythmic effect between 50% and 80%. Ajmaline was similarly effective when given in doses 100-1000 times higher. PGA1 and PGE2 were most effective in this model; the ED50-values of the other PGs were 2-3 times higher. The mode of action of PGs is unknown; the following factors are discussed: the influence on the ionic movements, the negative feedback mechanism on the release of adrenergic transmitter and central nervous effects.
D000404:Ajmaline / Q000627:therapeutic use; D000818:Animals; D000889:Anti-Arrhythmia Agents / Q000627:therapeutic use*; D001145:Arrhythmias, Cardiac / Q000139:chemically induced / Q000188:drug therapy*; D001464:Barium; D004195:Disease Models, Animal; D004305:Dose-Response Relationship, Drug; D011454:Prostaglandins A / Q000627:therapeutic use*; D011458:Prostaglandins E / Q000627:therapeutic use*; D011460:Prostaglandins F / Q000627:therapeutic use*; D011817:Rabbits
D000889:Anti-Arrhythmia Agents; D011454:Prostaglandins A; D011458:Prostaglandins E; D011460:Prostaglandins F; D000404:Ajmaline; D001464:Barium
Vergleich der antiarrhythmischen Wirkungen von PGA1, PGA2, PGE1, PGE2 und PGF2a am BaCl2-Arrhythmie-Modell des wachen Kaninchens