An investigation and some parameters that affect the galactosamine model of hepatitis in the rat.
1. The effect of d-galactosamine hydrochloride on the livers of rats was observed by measuring serum transaminase levels and histological examination. 2. Galactosamine caused dose related liver cell damage when given i.p. and s.c. but was ineffective when given orally. 3. The time of maximum effect was 24--48 h after administration. 4. The liver cell damage was modified by the oestrus cycle in female rats. 5. Galactosamine when given in proportion to body weight tended to be less effective as body weight increased.
D000284:Administration, Oral; D000410:Alanine Transaminase / Q000097:blood; D000469:Alkaline Phosphatase / Q000097:blood; D000818:Animals; D001219:Aspartate Aminotransferases / Q000097:blood; D001835:Body Weight; D056486:Chemical and Drug Induced Liver Injury / Q000201:enzymology; D004054:Diethylstilbestrol / Q000494:pharmacology; D004195:Disease Models, Animal; D004305:Dose-Response Relationship, Drug; D004971:Estrus; D005260:Female; D005688:Galactosamine / Q000008:administration & dosage / Q000494:pharmacology*; D007274:Injections, Intraperitoneal; D007279:Injections, Subcutaneous; D007770:L-Lactate Dehydrogenase / Q000097:blood; D008297:Male; D011247:Pregnancy; D051381:Rats; D012737:Sex Factors; D013045:Species Specificity; D013997:Time Factors
D004054:Diethylstilbestrol; D005688:Galactosamine; D007770:L-Lactate Dehydrogenase; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase; D000469:Alkaline Phosphatase