Complement-dependent and cell-dependent antiplatelet humoral antibody in sera from multi-transfused patients.
Sera from eight multi-transfused patients, who were resistant to platelet trans-fusions from allogeneic donors, were tested for antiplatelet humoral antibody. Complement-dependent cytotoxic humoral antibody against platelets was found in sera from six of eight patients. Cell-dependent cytotoxic humoral antibody against platelets was found in sera from four of seven of these patients. Sera from two patients had cell-dependent antiplatelet activity but no detectable complement-dependent antiplatelet activity. Results of this study argue that both complement-dependent and cell-dependent humoral immunity may be important pathways for in vivo resistance to platelets.
D001792:Blood Platelets / Q000276:immunology*; D003165:Complement System Proteins / Q000378:metabolism*; D003601:Cytotoxicity Tests, Immunologic; D006680:HLA Antigens / Q000032:analysis; D006801:Humans; D007111:Immunity, Cellular; D007518:Isoantibodies / Q000032:analysis*; D013997:Time Factors; D065227:Transfusion Reaction
D006680:HLA Antigens; D007518:Isoantibodies; D003165:Complement System Proteins