Incorporation into endogenous metabolic pathways of small fragments derived from I.C.I, 58,834(vioxazine).
1. Metabolic degradation of the tetrahydro-oxazine ring of 2-(2-ethoxyphenoxymethyl)-2,3,5,6-tetrahydro-1,4-oxazine (I.C.I. 58,834) gives rise to one- or two-carbon fragments which are utilized by endogenous metabolic pathways. 2. Evidence of this in dogs is shown by the 14C-labelled residues in tissues, 14C-labelled material in blood which has a half-life of three weeks, and elimination of [14C]urea in urine. 3. The same phenomenon occurs in rat, mouse and man, but to a smaller extent than in the dog. 4. Intravenous administration of [14C]ethanolamine to a dog gave rise to residual 14C blood levels with a half-life comparable to that produced by metabolic incorporation of 14C from 14C-I.C.I. 58,834.
D000284:Administration, Oral; D000818:Animals; D000928:Antidepressive Agents / Q000097:blood / Q000378:metabolism* / Q000652:urine; D002250:Carbon Radioisotopes; D055598:Chemical Phenomena; D002621:Chemistry; D004285:Dogs; D004983:Ethanolamines / Q000097:blood / Q000652:urine; D005260:Female; D006801:Humans; D008297:Male; D051379:Mice; D009025:Morpholines / Q000097:blood / Q000378:metabolism* / Q000652:urine; D009928:Organ Specificity; D010078:Oxazines / Q000097:blood / Q000378:metabolism / Q000652:urine; D051381:Rats; D014508:Urea / Q000652:urine
D000928:Antidepressive Agents; D002250:Carbon Radioisotopes; D004983:Ethanolamines; D009025:Morpholines; D010078:Oxazines; D014508:Urea