Quantitation of gold in skin in chrysiasis.
Skin, plasma, hair, and nail gold levels were determined in three groups of patients with rheumatoid arthritis comprising: I. Three patients on long term gold therapy exhibiting altered skin pigmentation (chrysiasis); II. Five patients on long term gold therapy exhibiting normal skin pigmentation; III. Two patients starting gold therapy. Group I had higher skin gold levels (50-140 mug/g) than Group II (7.5-13 mug/g) while Group II had minimal levels. Hair and nail gold levels were not much higher than gold levels in non-gold treated individuals. The possible role of skin in the storage or excretion of gold is discussed.
D001172:Arthritis, Rheumatoid / Q000188:drug therapy*; D004305:Dose-Response Relationship, Drug; D006046:Gold / Q000009:adverse effects / Q000032:analysis* / Q000627:therapeutic use; D006197:Hair / Q000032:analysis; D006801:Humans; D009262:Nails / Q000032:analysis; D010859:Pigmentation Disorders / Q000139:chemically induced*; D012867:Skin / Q000032:analysis* / Q000648:ultrastructure
D006046:Gold