Management of Candida peritonitis by prolonged peritoneal lavage containing 5-fluorocytosine.
A 55 year old woman on chronic maintenance peritoneal dialysis developed Candida albicans peritonitis. This was successfully treated by continous five day peritoneal lavage containing 5-fluorocytosine. By this technique stable serum levels of the drug (58 mug/ml +/- 3.2 SEM) could be maintained. The peritoneal clearance of 5-fluorocytosine was found to be 7.5 ml/min (for peritoneal dialysis flow rate 1.2 1/hr) and the serum half-life 34 hours. The use of this drug in renal failure and its kinetics are reviewed.
D002177:Candidiasis / Q000188:drug therapy / Q000628:therapy*; D003596:Cytosine / Q000031:analogs & derivatives*; D005260:Female; D005437:Flucytosine / Q000009:adverse effects / Q000627:therapeutic use*; D006207:Half-Life; D006801:Humans; D008875:Middle Aged; D010530:Peritoneal Dialysis; D010537:Peritoneum / Q000378:metabolism; D010538:Peritonitis / Q000188:drug therapy / Q000628:therapy*
D003596:Cytosine; D005437:Flucytosine