Lack of induction of dominant lethals in mice by orally administered AF-2.
In a series of toxicity tests, male mice of three inbred strains were exposed to several doses of orally administered furylfuramide (AF-2). Subsequent to these test the effects of AF-2, as measured by induced dominant lethals, were tested in strain DBA/2J mice. AF-2 at the doses used in this study was relatively non-toxic to the strains of mice tested. No indication of AF-2 induced dominant lethality was observed.
D000178:Acrylamides / Q000008:administration & dosage / Q000494:pharmacology* / Q000633:toxicity; D000284:Administration, Oral; D000818:Animals; D020964:Embryo Loss; D005260:Female; D005298:Fertility / Q000187:drug effects; D005520:Food Preservatives; D005799:Genes, Dominant; D005804:Genes, Lethal; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D009153:Mutagens / Q000494:pharmacology; D009581:Nitrofurans / Q000008:administration & dosage / Q000494:pharmacology / Q000633:toxicity; D011247:Pregnancy
D000178:Acrylamides; D005520:Food Preservatives; D009153:Mutagens; D009581:Nitrofurans