Comparative toxicity of N-hydroxy-2-acetylaminofluorene in several strains of rats.
Male Spraque-Dawley rats were 6 or 7 times more susceptible than females to the acute toxic effects of a single i.p. injection of N-hydroxy-2-acetylaminofluorene. The N-hydroxy compound were equally toxic in male and female Fischer rats and about twice as toxic to male as to female Wistar rats. A negative correlation between the 50% lethal dose of N-hydroxy-2-acetylaminofluorene and hepatic N-hydroxy-2-acetylaminofluorene sulfotransferase activity was found. These data substantiate earlier indications that the level of the liver sulfotransferase is an important factor in determining the degree of toxicity of N-hydroxy-2-acetylaminofluorene. It is suggested that the reported sex difference in the hepatocarcinogenicity of N-hydroxy-2-acetylaminofluorene might be peculiar to the Sprague-Dawley rat.
D000818:Animals; D005260:Female; D005449:Fluorenes; D006881:Hydroxyacetylaminofluorene; D007928:Lethal Dose 50; D008099:Liver / Q000201:enzymology; D008113:Liver Neoplasms / Q000139:chemically induced* / Q000201:enzymology; D008297:Male; D009374:Neoplasms, Experimental / Q000139:chemically induced / Q000201:enzymology; D051381:Rats; D011919:Rats, Inbred Strains; D012737:Sex Factors; D013466:Sulfurtransferases / Q000378:metabolism
D005449:Fluorenes; D006881:Hydroxyacetylaminofluorene; D013466:Sulfurtransferases