Effect of thyroidectomy on the activity of alpha-glucosidases and acid hydrolases in the small intestine of rats during weaning.
Adrenalectomy performed on 14-day-old rats delayed the usual increase of sucrase and maltase activity as well as the decrease of acid beta-galactosidase, beta-glucuroindase and N-acetyl-beta-glucosaminidase activity during the third postnatal week. Since these changes were only delayed, the role of the thyroid was explored. Thyroidectomy performed simultaneously with adrenalectomy on 14-day-old rats did not influence the increase in body weight and growth of the small intestine (already slowed down by adrenalectomy), but caused a further substantial delay in the maturation of  the enzyme profile of the small intestine. Our results indicate that the thyroid is involved in regulation of the hydrolases studied.
D000315:Adrenalectomy; D000367:Age Factors; D000818:Animals; D005696:Galactosidases / Q000378:metabolism; D005959:Glucosidases / Q000378:metabolism; D005966:Glucuronidase / Q000378:metabolism; D006026:Glycoside Hydrolases / Q000378:metabolism*; D006596:Hexosaminidases / Q000378:metabolism; D007082:Ileum / Q000201:enzymology; D007421:Intestine, Small / Q000201:enzymology*; D007583:Jejunum / Q000201:enzymology; D051381:Rats; D013393:Sucrase / Q000378:metabolism; D013961:Thyroid Gland / Q000502:physiology*; D013965:Thyroidectomy; D014886:Weaning
D005696:Galactosidases; D005959:Glucosidases; D006026:Glycoside Hydrolases; D006596:Hexosaminidases; D005966:Glucuronidase; D013393:Sucrase