[Anti-phalloidine activity of the silymarins silybine and disilybine].
Originating from silybin, a phenylchromanone from Silybum marianum (L.) Gaertn., a dimer -- disilybin -- was prepared. Disilybin exhibits a phalloidin antagonistic activity at least 10 times that of silybin with regards to a dose of the same weight.
D000818:Animals; D001665:Binding Sites; D002462:Cell Membrane / Q000378:metabolism; D005260:Female; D005419:Flavonoids / Q000494:pharmacology*; D051379:Mice; D009842:Oligopeptides / Q000037:antagonists & inhibitors*; D010590:Phalloidine / Q000037:antagonists & inhibitors* / Q000506:poisoning; D011041:Poisoning / Q000517:prevention & control; D012838:Silymarin / Q000031:analogs & derivatives / Q000494:pharmacology*
D005419:Flavonoids; D009842:Oligopeptides; D012838:Silymarin; D010590:Phalloidine
Zur anti-phalloidin-Aktivität der Silymarine Silybin und Disilybin