Sequential use of coccidiostats: effect on development by Eimeria tenella of resistance to amprolium, nicarbazin, Unistat, and zoalene.
A strain of the cecal coccidian of chickens, Eimeria tenella, was propagated serially in chickens fed mash containing amprolium, nicarbazin, Unistat, or zoalene. Each group of chickens received a different coccidiostat on a rotating basis. The strain was propagated through 40 groups of chickens; thus, the strain was intermittently exposed 10 times to each coccidiostat. The end product of this simulated shuttle program of prophylactic anticoccidial medication was a strain resistant to three of the four coccidiostats involved. Resistance to nicarbazin was not evident.
D000670:Amprolium / Q000494:pharmacology / Q000627:therapeutic use*; D000818:Animals; D001549:Benzamides / Q000494:pharmacology / Q000627:therapeutic use*; D002224:Carbanilides / Q000627:therapeutic use*; D002645:Chickens; D003048:Coccidiosis / Q000662:veterinary*; D003049:Coccidiostats / Q000494:pharmacology / Q000627:therapeutic use*; D004135:Dinitolmide / Q000494:pharmacology / Q000627:therapeutic use*; D004351:Drug Resistance; D004539:Eimeria / Q000187:drug effects*; D009528:Nicarbazin / Q000494:pharmacology / Q000627:therapeutic use*; D009574:Nitro Compounds / Q000627:therapeutic use; D010847:Picolines / Q000031:analogs & derivatives*; D011201:Poultry Diseases / Q000517:prevention & control*
D001549:Benzamides; D002224:Carbanilides; D003049:Coccidiostats; D009574:Nitro Compounds; D010847:Picolines; D009528:Nicarbazin; C008599:nitromide; D004135:Dinitolmide; D000670:Amprolium