[The effect of N-nitrosomethylurea on organ cultures of human embryonal lung tissue].
A direct effect of NMU (0.05 mg/ml) on human embryonal pulmonary tissue (22-24 week old fetuses) has been studied in various duration of cultivation: from 3 to 33 days. During the first period of the experiment the NMU action produced marked dystrophic changes and death of a considerable number of experimental cultures, as compared with the corresponding intact control cultures. Starting from the 10th day the survival of cultures under experiment was higher, in general, than in the control. Moreover, hyperplastic changes developed in them, which frequency rising from 7.7% to 39.1%. These were absent in control series.
D005260:Female; D005315:Fetal Diseases / Q000139:chemically induced*; D006801:Humans; D006965:Hyperplasia / Q000139:chemically induced; D008168:Lung / Q000196:embryology; D008171:Lung Diseases / Q000139:chemically induced*; D008770:Methylnitrosourea / Q000633:toxicity*; D008938:Mitosis; D009336:Necrosis / Q000139:chemically induced; D009607:Nitrosourea Compounds / Q000633:toxicity*; D009924:Organ Culture Techniques; D009928:Organ Specificity; D011247:Pregnancy; D013997:Time Factors
D009607:Nitrosourea Compounds; D008770:Methylnitrosourea
Deĭstvie N-nitrozometilmocheviny na organnye kul'tury émbrional'noĭ legochnoĭ tkani cheloveka