Narcotic withdrawal like mouse jumping produced by amphetamine and L-DOPA.
Upward jumping in mice that resembled the narcotic-withdrawal syndrome was produced by a combination of amphetamine (4 mg/kg) and L-DOPA (400 mg/kg) administration. Neither drug alone caused that jumping. Pretreatment with haloperidol (0.16 mg/kg) or pimozide (0.08 mg/kg) but not with phentolamine (10mg/kg) effectively blocked amphetamine-dopa jumping. After DOPA there was an increase in the brain levels of DOPA, dopamine and norepinephrine. Amphetamine, ineffective in itself, enhanced DOPA-induced elevation of brain DOPA and dopamine without affecting brain norepinephrine levels.
D000661:Amphetamine / Q000494:pharmacology*; D000818:Animals; D001923:Brain Chemistry / Q000187:drug effects; D004295:Dihydroxyphenylalanine / Q000494:pharmacology*; D004298:Dopamine / Q000032:analysis; D005470:Fluorometry; D006220:Haloperidol / Q000494:pharmacology; D006801:Humans; D007980:Levodopa / Q000032:analysis; D008297:Male; D051379:Mice; D009043:Motor Activity / Q000187:drug effects*; D009638:Norepinephrine / Q000032:analysis; D010646:Phentolamine / Q000494:pharmacology; D010868:Pimozide / Q000494:pharmacology; D013375:Substance Withdrawal Syndrome
D010868:Pimozide; D007980:Levodopa; D004295:Dihydroxyphenylalanine; D000661:Amphetamine; D006220:Haloperidol; D004298:Dopamine; D009638:Norepinephrine; D010646:Phentolamine