Comparsion of hydroxyindole-O-methyltransferse levels in pineal glands of normal, blinded, and congenitally anophthalmic guiena pigs.
The level of pineal hydroxyindole-O-methyltransferase activity was measured in normal sighted, normal blinded, and congenitally anophthalmic guinea pigs at 1100-1200 and 2300-2400 h. Significant day-night differences were found in the normal sighted and normal blinded guinea pigs; however, the levels were markedly elevated in the normal blinded guinea pigs. The congenitally anophthalmic guinea pigs did not demonstrate a difference between day and night activities. Both the day and night levels of hydroxyindole-O-methyltransferase activities in the latter animals were slightly less than the low daytime levels for the normal, sighted guinea pigs.
D000121:Acetylserotonin O-Methyltransferase / Q000378:metabolism*; D000818:Animals; D000853:Anophthalmos / Q000201:enzymology*; D001766:Blindness / Q000201:enzymology*; D002940:Circadian Rhythm; D006168:Guinea Pigs; D008780:Methyltransferases / Q000378:metabolism*; D010870:Pineal Gland / Q000201:enzymology*
D008780:Methyltransferases; D000121:Acetylserotonin O-Methyltransferase