Synthesis and study of glutaryl-S-(omega-aminoalkyl)-L-cysteinylglycines as inhibitors of glyoxalase I.
Glutaryl-S-(8-aminooctyl)-L-cysteinylglycine and glutaryl -S-(10-aminodecyl)-L-cysteinylglycine have been prepared by a seven-step procedure as potential ligands for affinity chromatography purification of mouse liver glyoxalase I. Both compounds exhibited nonlinear, mixed-type inhibition of the enzyme. The decyl derivative was a more effective inhibitor than was the octyl analog.
D000818:Animals; D001665:Binding Sites; D002846:Chromatography, Affinity; D003545:Cysteine / Q000138:chemical synthesis / Q000494:pharmacology; D004151:Dipeptides / Q000138:chemical synthesis* / Q000494:pharmacology; D005977:Glutarates / Q000138:chemical synthesis / Q000494:pharmacology; D005998:Glycine / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000494:pharmacology; D007700:Kinetics; D007791:Lactoylglutathione Lyase / Q000037:antagonists & inhibitors*; D008024:Ligands; D008099:Liver / Q000201:enzymology; D008190:Lyases / Q000037:antagonists & inhibitors*; D051379:Mice; D011485:Protein Binding
D004151:Dipeptides; D005977:Glutarates; D008024:Ligands; D008190:Lyases; D007791:Lactoylglutathione Lyase; D003545:Cysteine; D005998:Glycine