Minimal-lesion nephrotic syndrome with early resistance to steroid therapy.
The initial and long-term clinical course of six children with steroid-resistant, minimal-lesion nephrotic syndrome was evaluated. All children experienced remission after two to five weeks of combined cyclophosphamide-prednisone therapy. Following cyclophosphamide treatment, three patients have relapsed and have become steroid sensitive. The clinical outcome was quite favorable. These data suggest: (1) cyclophosphamide may induce a prompt remission in patients with minimal glomerular lesions who have early resistance to corticosteroids; (2) relapses which occur after cyclophosphamide should be treated with prednisone alone, even though the patient was previously steroid resistant; (3) the ultimate outcome is related more to the nature of the histopathologic lesion than to a lack of steroid responsiveness.
D001806:Blood Urea Nitrogen; D002675:Child, Preschool; D003404:Creatinine / Q000097:blood; D003520:Cyclophosphamide / Q000627:therapeutic use*; D004351:Drug Resistance; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D007677:Kidney Function Tests; D007678:Kidney Glomerulus / Q000473:pathology; D008297:Male; D009404:Nephrotic Syndrome / Q000188:drug therapy*; D011241:Prednisone / Q000627:therapeutic use*; D011507:Proteinuria / Q000175:diagnosis; D013997:Time Factors
D003520:Cyclophosphamide; D003404:Creatinine; D011241:Prednisone