Intravenous cholangiography in different degrees of common bile duct obstruction. An experimental study in the dog.
A total of 83 cholangiograms was performed in three cholecystectomized dogs equipped with Thomas cannulas through which complete and different degrees of incomplete common bile duct obstruction were produced. With incomplete common bile duct obstruction, the iodine concentration in the bile necessary for radiographic visualization of the common duct was always obtained for all three tested iodipamide dosages of .3, .6, and 1.2 ml/kg, infused over 30 minutes. The largest dose resulted in the highest biliary iodine concentrations. With increasing obstruction, an increasing delay of the biliary iodipamide excretion was noted. With complete common bile duct obstruction the iodine concentration in the bile necessary for radiographic visualization of the common duct was never obtained, even with an iodipamide dose increased to 1.8 ml/kg and/or prolongation of the contrast material infusion time from 30 minutes to 2 and 6 hours. Nevertheless, the highest biliary iodine concentration in complete common bile duct obstruction resulted with the largest iodipamide dose (1.8 ml/kg) and the shortest infusion time (30 minutes).
D000818:Animals; D001646:Bile / Q000032:analysis; D001660:Biliary Tract Diseases / Q000000981:diagnostic imaging; D002758:Cholangiography / Q000379:methods*; D002763:Cholecystectomy; D003135:Common Bile Duct / Q000000981:diagnostic imaging*; D004285:Dogs; D004305:Dose-Response Relationship, Drug; D007263:Infusions, Parenteral; D007455:Iodine / Q000032:analysis; D007458:Iodipamide / Q000008:administration & dosage / Q000032:analysis / Q000378:metabolism; D008099:Liver / Q000378:metabolism; D008297:Male; D011312:Pressure; D013997:Time Factors
D007455:Iodine; D007458:Iodipamide