[Liver damage due to N-propyl-ajmalin bitartrate (NPAB)].
The authors report on four cases of immediate hepatotoxic reaction following diagnostic re-exposure. In checking 27 patients who had received NPAB treatment for the first time, four were found to have a hepatotoxic reaction that developed within 13--20 days after beginning the treatment. In view of the significance of NPAB for the treatment of cardiac rhythm disorders, further such studies are required in order to define the actual risk involved in this procedure.
D000328:Adult; D000404:Ajmaline / Q000009:adverse effects* / Q000627:therapeutic use; D000906:Antibodies / Q000032:analysis; D001145:Arrhythmias, Cardiac / Q000188:drug therapy*; D001663:Bilirubin / Q000097:blood; D056486:Chemical and Drug Induced Liver Injury; D002779:Cholestasis / Q000139:chemically induced; D004804:Eosinophils; D005260:Female; D006801:Humans; D007684:Kidney Tubules; D008099:Liver / Q000503:physiopathology; D008875:Middle Aged; D009130:Muscle, Smooth; D013961:Thyroid Gland; D000637:Transaminases / Q000097:blood
D000906:Antibodies; D000404:Ajmaline; D000637:Transaminases; D001663:Bilirubin
Leberschäden unter N-Propyl-Ajmalin-Bitartrat (NPAB)