[Influencing of acetylation and corticosterone biosynthesis through long-term pantothenic acid deficiency in rats].
The effect of different dietary intake of pantothenic acid (150;100;25 and 0% of the requirement) on the metabolism of rats was studied during 15 months. The ability of the adrenals for synthesis of corticosterone and the rate of acetylation of a sulfonamid (Sulfisomidin) were taken as parameters. The above mentioned parameters were influenced significantly already after two weeks and a pantothenic acid free diet containing the antagonist omega-methyl-pantothenic acid. With a 25% supply of pantothenic acid and without omega-methyl-pantothenic acid it lasted half a year until significant alterations of acetylation could be demonstrated. The synthetic ability of the adrenals for corticosteroids was significantly increased after a year in the 25% group. After the end of the study, this hyperfunctional state was followed by hypofunction, resulting in a significantly reduced ability of synthesis of the glands. Studies of this type were conducted to obrain basic informations for later experiments in human beings.
D000107:Acetylation; D000818:Animals; D003345:Corticosterone / Q000096:biosynthesis* / Q000097:blood; D004032:Diet; D008297:Male; D010205:Pantothenic Acid / Q000172:deficiency*; D051381:Rats; D013449:Sulfonamides / Q000097:blood*; D013997:Time Factors; D014804:Vitamin B Deficiency / Q000097:blood / Q000378:metabolism*
D013449:Sulfonamides; D010205:Pantothenic Acid; D003345:Corticosterone
Beeinflussung des Acetylierungsvermögens und der Corticosteron-Biosynthese durch Pantothensäuremangel im Langzeitversuch mit Ratten