Macromolecular complexes produced by 1,3-propanesultone.
1,3-Propanesultone produces in vitro complexes between DNA and DNA, DNA and RNA, RNA, and RNA, DNA and proteins, and possibly RNA and proteins. All these interactions were detected with a variety of independent analytical techniques. Increased attachment of the 1,3-propanesultone-treated DNA to the microsomal membrane and enhanced adsorption to and penetration into Ehrlich ascites tumor cells were also observed. 1,3-Propanesultone was the second small-ring alkylating carcinogen studied in this laboratory that was found to produce such macromolecular complexes. The possibility that these highly diverse structures may be involved in chemical mutagenesis and tumorigenesis is considered.
D000477:Alkylating Agents / Q000494:pharmacology*; D000818:Animals; D002273:Carcinogens / Q000494:pharmacology*; D002286:Carcinoma, Ehrlich Tumor; D002478:Cells, Cultured; D002850:Chromatography, Gel; D004269:DNA, Bacterial / Q000378:metabolism; D004273:DNA, Neoplasm / Q000378:metabolism; D008566:Membranes / Q000378:metabolism; D051379:Mice; D008862:Microsomes, Liver / Q000648:ultrastructure; D008970:Molecular Weight; D009282:Naphthalenesulfonates / Q000494:pharmacology*; D011407:Propane / Q000031:analogs & derivatives; D011506:Proteins / Q000378:metabolism; D012329:RNA, Bacterial / Q000378:metabolism; D012334:RNA, Neoplasm / Q000378:metabolism; D012710:Serum Albumin, Bovine / Q000378:metabolism
D000477:Alkylating Agents; D002273:Carcinogens; D004269:DNA, Bacterial; D004273:DNA, Neoplasm; D009282:Naphthalenesulfonates; D011506:Proteins; D012329:RNA, Bacterial; D012334:RNA, Neoplasm; D012710:Serum Albumin, Bovine; D011407:Propane