Medullary carcinoma of the thyroid. Cellular immune response to tumor antigen in a heritable human cancer.
We have found inhibition of mononuclear leukocyte migration in response to tumor antigen in a group of patients with medullary carcinoma of the thyroid, a cancer inherited as an autosomal dominant. This immune response was not present in a group of family members who do not have cancer.
D000951:Antigens, Neoplasm; D002277:Carcinoma / Q000235:genetics* / Q000276:immunology; D002464:Cell Migration Inhibition; D006801:Humans; D007111:Immunity, Cellular; D009000:Monocytes / Q000276:immunology; D013964:Thyroid Neoplasms / Q000235:genetics* / Q000276:immunology
D000951:Antigens, Neoplasm