Studies of t6/t6 mouse embryos.
The phenocritical period of the t6/t6 genome extends from the late blastocyst substages through the elongated egg-cylinder stage. Most of the homozygous mouse embryos die during the short egg-cylinder stage. The viable egg-cylinder staged t6/t6 embryos can be distinguished from their phenotypically wild-type litter-mates at both the light and electron microscopic levels. The distinguishing characteristics of these embryos are aberrantly arranged entodermal cells, excessive cytoplasmic lipid and crystal-containing mitochondria. These same features are also characteristic of those mutant embryos which are developmentally arrested at both the short and elongated egg-cylinder stages. Over 50% of the t6/t6 embryos can be identified as early as the late blastocyst substages by the presence of large, electron-dense cytoplasmic lipid droplets.
D000483:Alleles; D000818:Animals; D001755:Blastocyst / Q000648:ultrastructure; D003594:Cytoplasmic Granules / Q000648:ultrastructure; D004475:Ectoderm / Q000648:ultrastructure; D004622:Embryo, Mammalian / Q000648:ultrastructure; D005260:Female; D005804:Genes, Lethal; D005808:Genes, Recessive; D006720:Homozygote; D008297:Male; D051379:Mice / Q000196:embryology*; D008807:Mice, Inbred BALB C; D008815:Mice, Inbred Strains; D008928:Mitochondria / Q000648:ultrastructure; D009154:Mutation