[The antihepatotoxic effect of silymarine on lipid metabolism in the rat disturbed by phalloidine intoxication].
Single application of 600-750 mug phalloidine/kg body weight produces within 4-6 h a decrease of serum cholesterol esters and a rising concentration of free fatty acids and lysophosphatidyl choline in liver homogenate.  Analysis of fatty acids compounds in liver lipid fractions indicates an increase of shorter-chain fatty acids and a percentage diminution of highly unsaturated longer-chain fatty acids.  In the prophylactic test, and also when giving silymarine-N-methylglucamine-salt simultaneously with the toxic agent, most analysed parameters show a variance according to those of the nonintoxicated control group.  Correlation analysis of paramenters points out typical variations between normal, control and experimental animals.
D000410:Alanine Transaminase / Q000097:blood; D000438:Alcohols / Q000494:pharmacology / Q000627:therapeutic use; D000818:Animals; D000924:Anticholesteremic Agents / Q000494:pharmacology; D001219:Aspartate Aminotransferases / Q000097:blood; D056486:Chemical and Drug Induced Liver Injury / Q000188:drug therapy / Q000209:etiology / Q000378:metabolism*; D002784:Cholesterol / Q000097:blood; D005230:Fatty Acids, Nonesterified / Q000097:blood; D005419:Flavonoids / Q000494:pharmacology* / Q000627:therapeutic use; D005969:Glutamate Dehydrogenase / Q000097:blood; D008099:Liver / Q000378:metabolism*; D008297:Male; D009183:Mycotoxins; D010456:Peptides, Cyclic; D010743:Phospholipids / Q000097:blood / Q000378:metabolism*; D051381:Rats; D014280:Triglycerides / Q000097:blood
D000438:Alcohols; D000924:Anticholesteremic Agents; D005230:Fatty Acids, Nonesterified; D005419:Flavonoids; D009183:Mycotoxins; D010456:Peptides, Cyclic; D010743:Phospholipids; D014280:Triglycerides; D002784:Cholesterol; D005969:Glutamate Dehydrogenase; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase
Ein Beitrag zur Frage der antihepatotoxischen Wirkung von Silymarin auf den durch Phalloidinintoxikation gestörten Lipidstoffwechsel der Ratte