Variability of creatinine excretion of normal, phenylketonuric and galactosemic children, and children treated with anticonvulsant drugs.
Creatinine per minute excretion rates in individual voidings varied as much as 300-500 percent of the 24-hour value for several children. Creatinine excretion rates were significantly more variable for children treated with anticonvulsant drugs than for normal children. Riboflavin-creatinine ratios determined on individual voidings were variable but adequate although total riboflavin was low. No time of day was found when creatinine excretion was representative of the 24-hour value. The creatinine height index when calculated from timed individual voidings during a 24-hour period varied for some children from 0.5 to more than 1.5 times published norms.
D001827:Body Height; D001835:Body Weight; D002648:Child; D002675:Child, Preschool; D002940:Circadian Rhythm; D003404:Creatinine / Q000652:urine*; D005260:Female; D005693:Galactosemias / Q000652:urine*; D006801:Humans; D008297:Male; D010661:Phenylketonurias / Q000652:urine*; D010672:Phenytoin / Q000494:pharmacology*; D012256:Riboflavin / Q000652:urine; D013997:Time Factors
D010672:Phenytoin; D003404:Creatinine; D012256:Riboflavin