Abortive infection of L cells by influenza virus: absence of virion RNA synthesis.
Influenza virus multiplies productively in chick cells and abortively in L cells. The infecting influenza virus RNA genomes are less stable in infected L cells than in infected chick cells. However, transcription of the virus genome in L cells, while reduced in rate, is not decreased in extent. There is no detectable synthesis of virion RNA in L cells, and this is the most likely cause of the abortive infection.
D000818:Animals; D002642:Chick Embryo; D046508:Culture Techniques; D005347:Fibroblasts; D009980:Influenza A virus / Q000254:growth & development / Q000378:metabolism*; D007739:L Cells; D051379:Mice; D009693:Nucleic Acid Hybridization; D010761:Phosphorus Radioisotopes; D012367:RNA, Viral / Q000096:biosynthesis*; D014158:Transcription, Genetic; D014779:Virus Replication
D010761:Phosphorus Radioisotopes; D012367:RNA, Viral