Naproxen absorption in children.
A study was carried out in 9 children (mean age 10.8 years) suffering from rheumatic disorders to determine peak plasma levels and plasma curve of naproxen following the administration of a single oral dose of a suspension formulation. The results suggest that there is no significant difference in naproxen peak blood levels and half-life between adults and children and a twice-daily dosage regime, as in adults, should be suitable, therefore, for therapeutic use in children. The formulation was well-tolerated and no untoward effects were noted.
D000284:Administration, Oral; D000293:Adolescent; D000367:Age Factors; D000893:Anti-Inflammatory Agents / Q000008:administration & dosage / Q000097:blood / Q000378:metabolism*; D001171:Arthritis, Juvenile / Q000378:metabolism*; D002648:Child; D002675:Child, Preschool; D004305:Dose-Response Relationship, Drug; D006801:Humans; D007408:Intestinal Absorption; D009280:Naphthaleneacetic Acids / Q000008:administration & dosage / Q000097:blood / Q000378:metabolism*; D011422:Propionates / Q000008:administration & dosage / Q000097:blood / Q000378:metabolism*; D013535:Suspensions
D000893:Anti-Inflammatory Agents; D009280:Naphthaleneacetic Acids; D011422:Propionates; D013535:Suspensions