Estrogen secretion and its relation to corpus luteum formation in monkeys (Macaca fascicularis) given melatonin.
Daily injection of 10 mg of melatonin from the 7th through the 17th day of the menstrual cycle in the crab-eating monkey delays the appearance of increased secretion of progesterone or prevents it altogether. In the cycles following melatonin treatment, the time in the cycle when the preovulatory estrogen rise occurs is more variable and the frequency of a second estrogen peak increases.
D000818:Animals; D003338:Corpus Luteum / Q000187:drug effects*; D004967:Estrogens / Q000032:analysis / Q000378:metabolism*; D004971:Estrus / Q000187:drug effects; D005260:Female; D007031:Hypothalamus / Q000187:drug effects; D007279:Injections, Subcutaneous; D008252:Macaca fascicularis; D008550:Melatonin / Q000008:administration & dosage / Q000494:pharmacology*; D008598:Menstruation; D010060:Ovulation / Q000187:drug effects; D011247:Pregnancy; D011374:Progesterone / Q000097:blood; D011863:Radioimmunoassay; D012636:Secretory Rate / Q000187:drug effects
D004967:Estrogens; D011374:Progesterone; D008550:Melatonin