Pharmacological action of FD-008, a new dopamine-beta-hydroxylase inhibitor.
The effects of 5-(4'-chlorobutyl)-picolinic acid (FD-008), a new dopamine beta-hydroxylase inhibitor of fusaric acid derivatives, on the central nervous system in mice and rats were investigated. FD-008 and fusaric acid did not show marked effects on spontaneous movement, convulsion, sleeping time, tremor and conditioned avoidance response but lowered the body temperature of rats at 100 mg/kg p.o. FD-008 potentiated the depressive action of ethanol on conditioned avoidance response in spite of the lack of aldehyde dehydrogenase inhibition. FD-008 markedly depressed the performance on a shuttle box and lowered the body temperature in rats after reserpine treatment at a dose at which FD-008 per se had no effect.
D000284:Administration, Oral; D000445:Aldehyde Oxidoreductases / Q000037:antagonists & inhibitors; D000818:Animals; D001362:Avoidance Learning / Q000187:drug effects; D001831:Body Temperature / Q000187:drug effects; D003864:Depression, Chemical; D004221:Disulfiram / Q000494:pharmacology; D004299:Dopamine beta-Hydroxylase / Q000037:antagonists & inhibitors*; D004357:Drug Synergism; D004597:Electroshock; D000431:Ethanol / Q000494:pharmacology; D006591:Hexobarbital / Q000494:pharmacology; D006843:Hydrocarbons, Chlorinated / Q000494:pharmacology; D007279:Injections, Subcutaneous; D007928:Lethal Dose 50; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D009043:Motor Activity / Q000187:drug effects; D010848:Picolinic Acids / Q000494:pharmacology*; D051381:Rats; D012110:Reserpine / Q000494:pharmacology; D012640:Seizures / Q000517:prevention & control; D012890:Sleep / Q000187:drug effects
D006843:Hydrocarbons, Chlorinated; D010848:Picolinic Acids; D000431:Ethanol; D012110:Reserpine; D006591:Hexobarbital; D004299:Dopamine beta-Hydroxylase; D000445:Aldehyde Oxidoreductases; D004221:Disulfiram