Effect of vitamin B-12 deficiency on the hepatic tissue concentration of acyl carnitines.
Concentrations of carnitine, acetyl carnitine, propionyl carnitine, and long chain acyl carnitines have been measured in hepatic tissue of normal and vitamin B-12 deficient rats using radiolabelled butyrobetaine to label carnitine pools. Increased levels of propionyl carnitine were seen in the livers of vitamin B-12 deprived animals when compared to those from normal animals. Methylmalonyl carnitine was not detected in the B-12 deprived animals. Free carnitine levels were no different in the livers from the B-12 deprived animals than from the normal control animals.
D000818:Animals; D002331:Carnitine / Q000378:metabolism*; D002332:Carnitine O-Acetyltransferase / Q000378:metabolism; D003065:Coenzyme A / Q000378:metabolism; D005227:Fatty Acids / Q000378:metabolism*; D008099:Liver / Q000378:metabolism*; D008314:Malonates / Q000378:metabolism; D011422:Propionates / Q000378:metabolism; D051381:Rats; D014806:Vitamin B 12 Deficiency / Q000378:metabolism*
D005227:Fatty Acids; D008314:Malonates; D011422:Propionates; D002332:Carnitine O-Acetyltransferase; D002331:Carnitine; D003065:Coenzyme A