Effect of chronic pentobarbital treatment on blood-cerebrospinal fluid kinetics.
Cats were made tolerant and physically dependent by twice daily equieffective anesthetic dosing with sodium pentobarbital intragastrically for 5 weeks. Serial blood and CSF samples were simultaneously collected on day 1 and day 35 and analyzed for pentobarbital by a gas chromatographic method. Pentobarbital penetration into CSF was rapid and unchanged by chronic treatment. The concentration in blood and CSF increased significantly with chronic treatment; however, the relative CSF/blood concentration ratios were unchanged.
D000818:Animals; D002415:Cats; D002531:Cerebellum / Q000378:metabolism; D004361:Drug Tolerance; D005260:Female; D007700:Kinetics; D008297:Male; D008526:Medulla Oblongata / Q000378:metabolism; D010424:Pentobarbital / Q000097:blood / Q000134:cerebrospinal fluid / Q000494:pharmacology*; D013997:Time Factors
D010424:Pentobarbital