Disruption of isolated peritoneal mast cells of the rat by human serum and that by other species.
The effect of human sera on isolated peritoneal mast cells of the rat has been studied in an investigation of non-specific mast cell-disrupting factors. This action of the serum shows some correlation with its haemolytic effect but haemolysis is not increased by phospholipase A whereas the effect on mast cells is usually enhanced. Mast cell disruption produced by the sera of other species has also been studied, and it was found that some sera (e.g. that of pig) considerably reduced the mast cell disruption produced by human serum.
D000042:Absorption; D000327:Adsorption; D000818:Animals; D001202:Ascitic Fluid / Q000276:immunology*; D002417:Cattle; D003165:Complement System Proteins / Q000378:metabolism; D004912:Erythrocytes / Q000276:immunology; D006168:Guinea Pigs; D006461:Hemolysis; D006736:Horses; D006801:Humans; D007106:Immune Sera; D007668:Kidney / Q000276:immunology; D008407:Mast Cells / Q000276:immunology*; D010740:Phospholipases / Q000494:pharmacology; D011817:Rabbits; D051381:Rats / Q000276:immunology*; D013045:Species Specificity; D013552:Swine; D015054:Zymosan / Q000378:metabolism
D007106:Immune Sera; D003165:Complement System Proteins; D015054:Zymosan; D010740:Phospholipases