Lymphocytosis induced by polymethacrylic acid. Dose-effect and toxicity.
Intravenous polymethacrylic acid (PMAA) significantly increases the number of lymphocytes in the blood of the rat. The relationship between dose-effect and lymphocytosis is linear. The lethal dose in 30 days of PMAA is 120 mg/kg b.w. and the half-lethal dose 80 mg/kg b.w. The treatment with 40 mg/kg b.w. intravenous PMAA gives no toxic histological changes either in the lymph organs, the liver or the kidneys. Thus, PMAA appears to be, at present, a most suitable agent by which to provoke experimentally, migration of the reserve lymphocytes into the blood.
D000180:Acrylic Resins; D000818:Animals; D004305:Dose-Response Relationship, Drug; D007275:Injections, Intravenous; D007668:Kidney / Q000187:drug effects; D007928:Lethal Dose 50; D008099:Liver / Q000187:drug effects; D008208:Lymphatic System / Q000187:drug effects; D008218:Lymphocytosis / Q000139:chemically induced*; D008297:Male; D011109:Polymethacrylic Acids / Q000633:toxicity; D051381:Rats; D013997:Time Factors
D000180:Acrylic Resins; D011109:Polymethacrylic Acids