Intramuscular (15S)-15-methyl prostaglandin F2alpha for midtrimester and missed abortions.
The efficacy of intramuscular 15-me-PGF2alpha as an abortifacient was evaluated in 40 women between 14 and 20 weeks of gestation and 6 patients with missed abortions. Pregnancy was successfully terminated in all the cases. The injection-abortion interval was significantly lower in 20 patients (Group II) who had intracervical laminaria insertion prior to treatment with 15-me-PGF2alpha than in 10 women (Group I) without laminaria insertion (t = 7.2; P less than .001). Abortion was also accomplished in 10 women with ruptured membranes and 6 patients with missed abortions. Gastrointestinal side effects were minimal and acceptable when premedication with antiemetics and an antidiarrheal was used. This study demonstrates the availability of the intramuscular route--a simple, safe, reliable means of terminating pregnancy, especially during the early midtrimester period.
D000019:Abortifacient Agents; D000028:Abortion, Induced; D000030:Abortion, Missed / Q000188:drug therapy*; D000293:Adolescent; D000328:Adult; D000930:Antidiarrheals / Q000627:therapeutic use; D000932:Antiemetics / Q000627:therapeutic use; D003967:Diarrhea / Q000517:prevention & control; D005260:Female; D006801:Humans; D007273:Injections, Intramuscular; D011247:Pregnancy; D011262:Pregnancy Trimester, Second; D011460:Prostaglandins F / Q000008:administration & dosage* / Q000009:adverse effects / Q000627:therapeutic use; D014839:Vomiting / Q000517:prevention & control
D000019:Abortifacient Agents; D000930:Antidiarrheals; D000932:Antiemetics; D011460:Prostaglandins F