Effects of hydroxylamine on the consequences of long-lasting administration of morphine in mice. I. Effect on the morphine tolerance.
C57BL/6J mice were injected daily with increasing doses of morphine sulfate for 5 weeks. Twenty-four hours after the final morphine administration, they were injected intracranially with 10, 20 or 50 mul of a 0.3 M solution of hydroxylamine. Two weeks later, hot plate testing indicated that hydroxylamine interfered with the developed tolerance of the mice to morphine.
D000818:Animals; D001831:Body Temperature / Q000187:drug effects; D001835:Body Weight / Q000187:drug effects; D004361:Drug Tolerance; D005260:Female; D006801:Humans; D006898:Hydroxylamines / Q000494:pharmacology*; D051379:Mice; D008810:Mice, Inbred C57BL; D009020:Morphine / Q000494:pharmacology*; D009043:Motor Activity / Q000187:drug effects; D011930:Reaction Time / Q000187:drug effects; D013375:Substance Withdrawal Syndrome / Q000503:physiopathology; D013997:Time Factors
D006898:Hydroxylamines; D009020:Morphine