Resorption of 125I-labeled fibrin bioplast from the dorsal muscle of rats.
Fibrin bioplast is an implant material made from plasticized fibrin. The resorption and route of elimenation of 125I-tagged bioplast plates implanted into the back muscle of rats have been studied in 18 experiments. Variation in radioactivity of the implant, appearance of the activity in the urine and fecal output, supplemented with information on the radioactivity of the implant site and that of isolated organs, reveal that the elimination of bioplast begins on the 12th day and proceeds at an even rate without pathological tissue reactions. By the 42nd day 10 to 12% of the original material is present. The elimination of the implant material is complete and occurs mainly with urine through the kidneys.
D000818:Animals; D001672:Biocompatible Materials / Q000138:chemical synthesis; D001673:Biodegradation, Environmental; D005243:Feces / Q000032:analysis; D005337:Fibrin / Q000138:chemical synthesis / Q000378:metabolism / Q000652:urine; D007457:Iodine Radioisotopes; D008297:Male; D009132:Muscles / Q000033:anatomy & histology / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains
D001672:Biocompatible Materials; D007457:Iodine Radioisotopes; D005337:Fibrin