Obstructive jaundice associated with carcinoma of the prostate.
An unusual case of prostatic carcinoma presenting as severe obstructive jaundice is reported. After treatment with stilbestrol and bilateral orchidectomy, liver function tests became normal and lung metastases disappeared. During a second episode of jaundice due to serum hepatitis, liver function deteriorated following stilbestrol administration, and the drug was temporarily discontinued. The patient has been followed up for three years and liver function tests remain normal.
D000230:Adenocarcinoma / Q000150:complications* / Q000188:drug therapy; D001859:Bone Neoplasms; D002369:Castration; D056486:Chemical and Drug Induced Liver Injury; D002779:Cholestasis / Q000209:etiology*; D004054:Diethylstilbestrol / Q000009:adverse effects / Q000627:therapeutic use; D006509:Hepatitis B / Q000150:complications; D006801:Humans; D008099:Liver / Q000187:drug effects; D008111:Liver Function Tests; D008175:Lung Neoplasms; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D009362:Neoplasm Metastasis; D011471:Prostatic Neoplasms / Q000150:complications* / Q000188:drug therapy
D004054:Diethylstilbestrol