Calcium-binding property of cocaine and some of its active metabolites-formation of molecular complexes.
Cocaine, benzoylecgonine, benzoylnorecgonine, norcocaine, ecgonine methyl ester but not ecgonine formed distinct molecular complexes with calcium chloride of the general formula [B. CaC12-2H20]. The particularly strong interaction observed with benzoylecgonine, benzoylnorecgonine and calcium may play a role in the potent stimulant activity of these 2 compounds observed in rats after intracisternal administration.
D002118:Calcium / Q000032:analysis; D055598:Chemical Phenomena; D002621:Chemistry; D003042:Cocaine / Q000031:analogs & derivatives / Q000032:analysis; D013055:Spectrophotometry, Infrared
D003042:Cocaine; D002118:Calcium