[Inhibition of carbonic anhydrase by xipamide (4-chloro-sulfamoyl-2',6'-salicyloxylidide) in the modified Philpot test].
The inhibition  of carbonic anhydrase by xipamide (4-chloro-5-sulfamoyl-2',6'-salicyloxylidide, Aquaphor), a poorly watersoluble saluretic agent, is determined with the Philpot method in the presence of 5 per cent N,N-dimethyl-formamide.  The addition of the amide does not affect the enzyme.  For xipamide 1.1 times 10-5 M is found as the 50 per cent inhibitory concentration.
D000813:Anilides / Q000494:pharmacology; D002257:Carbonic Anhydrase Inhibitors / Q000494:pharmacology*; D004126:Dimethylformamide; D004232:Diuretics / Q000494:pharmacology*; D066298:In Vitro Techniques; D008722:Methods; D012457:Salicylamides / Q000494:pharmacology; D012995:Solubility; D013449:Sulfonamides; D014992:Xylenes / Q000032:analysis / Q000494:pharmacology
D000813:Anilides; D002257:Carbonic Anhydrase Inhibitors; D004232:Diuretics; D012457:Salicylamides; D013449:Sulfonamides; D014992:Xylenes; D004126:Dimethylformamide
Die Hemmung der Carboanhydrase durch Xipamid (4-Chlor-5-sulfamoyl-2',6'-salicyloxylidid) im modifizierten Philpot-Test