Potential anticancer agents II: antitumor and cytotoxic lignans from Linum album (Linaceae).
A phytochemical study of Linum album (Linaceae), guided by bioassay with the 9KB cell culture, resulted in the isolation of podophyllotoxin and a new lignan, 3'-demethylpodophyllotoxin; alpha-and beta-peltatins were identified by comparative TLC.
D000818:Animals; D000970:Antineoplastic Agents / Q000302:isolation & purification* / Q000627:therapeutic use; D002277:Carcinoma / Q000188:drug therapy; D002460:Cell Line; D002855:Chromatography, Thin Layer; D004353:Drug Evaluation, Preclinical; D007942:Leukemia, Experimental / Q000188:drug therapy; D008031:Lignin / Q000031:analogs & derivatives* / Q000302:isolation & purification / Q000627:therapeutic use; D009682:Magnetic Resonance Spectroscopy; D051379:Mice; D009062:Mouth Neoplasms / Q000188:drug therapy; D010946:Plants, Medicinal / Q000032:analysis*; D011034:Podophyllotoxin / Q000031:analogs & derivatives / Q000032:analysis / Q000302:isolation & purification
D000970:Antineoplastic Agents; D008031:Lignin; D011034:Podophyllotoxin