The haemolytic uraemic syndrome--a family study.
This study included patients, all relatives with the haemolytic uraemic syndrome, and 18 family members. The diagnosis was uncertain in one other and definite in four patients. Three of these four comprised a father and two of his children. Data are presented to emphasize the widespread nature of the disease. Other than hypertension, predisposing factors, and red cell and HL-A genetic markers, although sought, have not been found. Management is discussed with special reference to the one surviving patient. Early bilateral nephrectomy may be life-saving.
D000293:Adolescent; D000328:Adult; D000596:Amino Acids / Q000097:blood; D000914:Antibodies, Viral / Q000032:analysis; D001779:Blood Coagulation Factors; D001789:Blood Group Antigens; D002648:Child; D002675:Child, Preschool; D005260:Female; D006680:HLA Antigens / Q000032:analysis; D006463:Hemolytic-Uremic Syndrome / Q000235:genetics* / Q000473:pathology / Q000628:therapy; D006801:Humans; D007070:Immunoglobulin A / Q000032:analysis; D007074:Immunoglobulin G / Q000032:analysis; D007075:Immunoglobulin M / Q000032:analysis; D007223:Infant; D007527:Isoenzymes / Q000032:analysis; D007668:Kidney / Q000473:pathology; D008297:Male; D008875:Middle Aged; D010375:Pedigree; D012709:Serum Albumin / Q000032:analysis; D012712:Serum Globulins / Q000032:analysis
D000596:Amino Acids; D000914:Antibodies, Viral; D001779:Blood Coagulation Factors; D001789:Blood Group Antigens; D006680:HLA Antigens; D007070:Immunoglobulin A; D007074:Immunoglobulin G; D007075:Immunoglobulin M; D007527:Isoenzymes; D012709:Serum Albumin; D012712:Serum Globulins