The site of healing over after a local injury in the heart.
The fluorochrome, Procion yellow, does not detectably penetrate the intact carciac cells of a living rat auricle, but stains the injured ifbers. When healing over is prevented in a calcium-free solution, the dye that penetrates through a point injury diffuses away from the damaged spot across the intercalated discs over a distance of several cell lengths. However, after an injury of the same size performed in a calcium-containing solution, Procion yellow is taken upt by one cardiac cell only or by a small integral number of cellular units to the exclusion of adjacent cells. It is concluded that the permeability of the discs of an injured cardiac cell decreases during healing over.
D000818:Animals; D002118:Calcium / Q000502:physiology; D006335:Heart Injuries / Q000473:pathology / Q000503:physiopathology*; D010539:Permeability; D051381:Rats; D014945:Wound Healing
D002118:Calcium