Daily rhythm in human urinary melatonin.
The melatonin in urine samples from six healthy adult volunteers was concentrated on Amberlite XAD-2 resin, eluted with organic solvents, and quantitated by use of a bioassay technique (the dermal melanaphore response of larval anurans to melatonin in their bathing medium). The melatonin content of samples collected between 11 p.m. and 7 a.m. was, in each case, several times higher than that of samples collected between 7 a.m. and 3 p.m. or between 3 p.m. and 11 p.m.
D000328:Adult; D000367:Age Factors; D001681:Biological Assay; D002845:Chromatography; D002940:Circadian Rhythm; D005260:Female; D006801:Humans; D008297:Male; D008550:Melatonin / Q000652:urine*; D008875:Middle Aged; D012737:Sex Factors; D012997:Solvents
D012997:Solvents; D008550:Melatonin