Acetylmethionine as a source of methionine for the rat.
A-Acetyl-L-methionine and N-acetyl-D-methionine were compared with L-methionine and D-methionine as sources of methionine. These derivatives were added to a sulfer amino acid-limited diet containing 10% soybean protein isolate. Weight gains, food intake, and protein efficiency ratios (PER) were determined in growing rats. N-Acetyl-L-methionine, L-methionine, and D-methionine produced an equivalent growth response and increase in PER above that of the basal diet. There was no response to supplementation with N-acetyl-D-methionine. An equivalent maximum growth response of rats fed-L-methionine or N-acetyl-D-methionine. An equivalent maximum growth response of rats fed L-methionine or N-acetyl-L-methionine was obtained when the total dietary sulfur amino acids compromised 0.36-0.41% of the diet. The nutritional similarities of methionine and N-acetyl-L-methionine suggest that the latter may be useful as a supplement to diets containing vegetable proteins that are deficient in sulfur amino acids.
D000085:Acetates / Q000378:metabolism; D000603:Amino Acids, Sulfur / Q000172:deficiency; D000824:Animal Nutritional Physiological Phenomena; D000818:Animals; D001835:Body Weight; D003677:Deficiency Diseases / Q000188:drug therapy; D004044:Dietary Proteins / Q000378:metabolism; D005069:Evaluation Studies as Topic; D008297:Male; D008715:Methionine / Q000008:administration & dosage / Q000031:analogs & derivatives / Q000502:physiology; D014674:Plant Proteins, Dietary; D051381:Rats; D013025:Glycine max; D013237:Stereoisomerism; D013329:Structure-Activity Relationship
D000085:Acetates; D000603:Amino Acids, Sulfur; D004044:Dietary Proteins; D014674:Plant Proteins, Dietary; D008715:Methionine