Chronic alcoholism and endogenous gastrin.
Gastirn blood levels after the ingestion of a meat meal, either alone or associated with ethanol (1.0 gm./kg.), are higher and better sustained in dogs treated chronically with alcohol than in control animals. This greater gastrin-releasing capacity of the dog gastric antrum would be responsible for the increased parietal cell mass and gastric acid secretion shown by animals subjected to chronic alcohol intoxication.
D000437:Alcoholism / Q000503:physiopathology*; D000818:Animals; D002908:Chronic Disease; D004285:Dogs; D000431:Ethanol / Q000008:administration & dosage; D005215:Fasting; D005753:Gastric Mucosa / Q000378:metabolism; D005755:Gastrins / Q000097:blood / Q000378:metabolism*; D006801:Humans; D011863:Radioimmunoassay; D013997:Time Factors
D005755:Gastrins; D000431:Ethanol