Further studies on a transmissible entity in relation to the control of cancer in mice.
Tumor-bearing mice of the C3H/ST inbreds were used in this investigation. Of the 598 mice, 290 were controls, 248 received injections of 5-methyl cytidine dissolved in physiological salt solution, and 60 received injections of three nucleosides - adenosine, 6-methyl adenosine, and 5-methyl cytidine - also dissolved in physiological salt solution. The mice were divided into 6 groups based upon the number of generations of descent from a mouse injected with an alcohol-soluble liver extract. The criterion of tumor growth is the average increment of growth at the 20th observation period in the 7th week (3 per week). There is a cumulative inhibition of tumor growth, compared with controls, when 5-methyl cytidine is added to the effect of a transmissible entity which occurs in the lineal descendants of a tumor-bearing mouse injected with an alcohol-soluble liver extract and when the combination of three nucleosides in the same ratio of molar concentrations as in the liver extract is added to the effect of the transmissible entity.
D000241:Adenosine / Q000031:analogs & derivatives / Q000494:pharmacology; D000818:Animals; D003562:Cytidine / Q000031:analogs & derivatives / Q000494:pharmacology; D007125:Immunogenetics; D008110:Liver Extracts / Q000494:pharmacology; D008325:Mammary Neoplasms, Experimental / Q000276:immunology* / Q000517:prevention & control; D051379:Mice; D008809:Mice, Inbred C3H
D008110:Liver Extracts; D003562:Cytidine; D000241:Adenosine