A relationship between hexobarbitone sleeping time and susceptibility to mescaline in mice from different strains.
Males from the following strains were surveyed with respect to their hexobarbitone sleeping time: A2G, C57BR, C3H, F/st, CBA, ICFW and Schneider. Males from the same strains had previously been surveyed with respect to the inhibitory effect of mescaline on their emotional defaecation. There is a strong interstrain correlation between the 2 measures. This correlation was unexpected on theoretical grounds and may have important pharmacogenetic implications.
D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects* / Q000502:physiology; D003672:Defecation / Q000187:drug effects; D004644:Emotions / Q000187:drug effects; D005838:Genotype; D006591:Hexobarbital / Q000494:pharmacology*; D008297:Male; D008635:Mescaline / Q000494:pharmacology*; D051379:Mice; D008805:Mice, Inbred A / Q000502:physiology; D008809:Mice, Inbred C3H / Q000502:physiology; D008808:Mice, Inbred CBA / Q000502:physiology; D008815:Mice, Inbred Strains / Q000502:physiology*; D012890:Sleep / Q000187:drug effects*; D013045:Species Specificity
D006591:Hexobarbital; D008635:Mescaline