Hepatocytic ultrastructure in splenectomized rats treated with pregnenolone-16alpha-carbonitrile, a microsomal enzyme inducer.
Pregnenolone-16alpha-carbonitrile (PCN), given orally at the dose of 6.8 mg/100 g body wt, twice daily for 3 or 6 days, increased liver weight in intact rats, and reduced zoxazolamine paralysis in both unoperated and splenectomized animals. The steroid induced smooth endoplasmic reticulum proliferation in the hepatocytes of intact and splenectomized rats, while splenectomy alone caused rough endoplasmic reticulum fragmentation and vesiculation. It appears that the spleen does not influence the hepatic action of PCN.
D000818:Animals; D002467:Cell Nucleus / Q000648:ultrastructure; D004721:Endoplasmic Reticulum / Q000648:ultrastructure; D005260:Female; D006056:Golgi Apparatus / Q000648:ultrastructure; D008099:Liver / Q000033:anatomy & histology / Q000187:drug effects* / Q000648:ultrastructure; D008928:Mitochondria / Q000648:ultrastructure; D009929:Organ Size; D011285:Pregnenolone Carbonitrile / Q000494:pharmacology*; D051381:Rats; D013154:Spleen / Q000502:physiology*; D013156:Splenectomy
D011285:Pregnenolone Carbonitrile