Effect of different sedative drugs on the proliferation of bone marrow cells. Preliminary results.
Several drugs were assayed for their effect on bone marrow hematopoïetic cells proliferation. Chlorpromazine, barbiturates and benzopiperidine were found active only at toxic dosage. Propranolol and fluanison seem in the preliminary studies to lessen 3 H-thymidine incorporation in vitro at non toxic concentration.
D001853:Bone Marrow / Q000187:drug effects* / Q000378:metabolism; D001854:Bone Marrow Cells; D002746:Chlorpromazine / Q000494:pharmacology; D006801:Humans; D006993:Hypnotics and Sedatives / Q000494:pharmacology*; D010634:Phenobarbital / Q000494:pharmacology; D010880:Piperidines / Q000494:pharmacology; D011433:Propranolol / Q000494:pharmacology; D013936:Thymidine / Q000378:metabolism
D006993:Hypnotics and Sedatives; D010880:Piperidines; D011433:Propranolol; D002746:Chlorpromazine; D013936:Thymidine; D010634:Phenobarbital