[The mechanism of action of peptides acting on smooth muscle. II. Relationships between angiotensin II and adrenergic systems with reference to blood pressure regulation].
To explore the molecular and subcellular effects of Angiotensin II during the early phase of an experimental hypertension, biochemical and morphological changes induced by continued administration of subpressoric Angiotensin II doses were traced in rats. After the treatment, the endogenous noradrenalin and dopamine content was changed in various brain regions, the turnover rate of noradrenalin was lowered, and the neuronal 3H noradrenalin uptake was delayed and reduced. Electron microscopy revealed an increase in number and granulation of adrenergic vesicles in the hypothalamus, and characteristic changes at pre- and postsynaptic membrane complexes. The interaction between central effects of angiotensin II and the adrenergic system presumably involves disturbance at the level of neuronal membranes.
D000804:Angiotensin II / Q000494:pharmacology*; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects*; D001923:Brain Chemistry; D004298:Dopamine / Q000032:analysis; D007031:Hypothalamus / Q000187:drug effects; D009417:Nerve Tissue / Q000187:drug effects; D009638:Norepinephrine / Q000032:analysis / Q000378:metabolism; D051381:Rats; D013570:Synaptic Membranes / Q000187:drug effects; D013572:Synaptic Vesicles / Q000187:drug effects
D000804:Angiotensin II; D004298:Dopamine; D009638:Norepinephrine
Studien zum Wirkungsmechanismus glattmuskulär angreifender Peptide II. Beziehungen zwischen Angiotensin II und adrenergen Systemen im Hinblick auf die Blutdruckregulation