Effects on lipids, coagulation factors and liver histology of long-term ethanol administration to guinea-pigs.
The constant failure to produce a liver cirrhosis that can be ascribed to alcohol in the rat promoted the present study in guinea-pigs. The animals were given 40 per cent of calories as ethanol during 8 months. However, no alcoholic hepatitis or cirrhosis developed. Triglycerides and cholesterol increased in the liver and in serum. The persistance of liver triglyceride increase in spite of a rather low fat content of the diet is in contrast to experiences in the rat. A slight depression of coagulation factors II, VII, X and XI was observed in the ethanol-fed animals.
D000818:Animals; D001779:Blood Coagulation Factors / Q000096:biosynthesis*; D002784:Cholesterol / Q000378:metabolism; D004032:Diet; D004040:Dietary Carbohydrates; D004195:Disease Models, Animal; D000431:Ethanol / Q000494:pharmacology*; D005340:Fibrinogen / Q000096:biosynthesis; D006168:Guinea Pigs; D050356:Lipid Metabolism; D008106:Liver Cirrhosis, Experimental / Q000097:blood / Q000139:chemically induced* / Q000378:metabolism; D051381:Rats; D013045:Species Specificity; D014280:Triglycerides / Q000378:metabolism
D001779:Blood Coagulation Factors; D004040:Dietary Carbohydrates; D014280:Triglycerides; D000431:Ethanol; D005340:Fibrinogen; D002784:Cholesterol