The effect of some dithiocarbamic acids on dopamine-beta-hydroxylase and catecholamines level in rat's brain.
In search for selective dopamine-beta-hydroxylase inhibitors, we studied the effect of dimethyl-, monocyclohexyl-, and dicyclohexyldithiocarbamic acids on the activity of this enzyme and on dopamine and noradrenaline levels in rat's brain. All the three derivatives inhibit the activity of dopamine-beta-hydroxylase in brain; in the tested doses, their effectiveness is similar. Moreover, all three compounds decrease noradrenaline level in brain. The tested derivatives differ from one another in their effect on dopamine level in brain. Dimethyl- and monocyclohexyl derivatives increase while dicyclohexyl derivative decreases the level of this amine.
D000818:Animals; D001921:Brain / Q000187:drug effects / Q000201:enzymology / Q000378:metabolism*; D002395:Catecholamines / Q000096:biosynthesis / Q000378:metabolism*; D003510:Cyclohexanes / Q000494:pharmacology; D004125:Dimethyldithiocarbamate / Q000494:pharmacology; D004299:Dopamine beta-Hydroxylase / Q000378:metabolism*; D004794:Enzyme Repression / Q000187:drug effects; D005260:Female; D008297:Male; D051381:Rats; D013859:Thiocarbamates / Q000494:pharmacology*
D002395:Catecholamines; D003510:Cyclohexanes; D004125:Dimethyldithiocarbamate; D013859:Thiocarbamates; D004299:Dopamine beta-Hydroxylase