Chemical sterilization: effects of a single high dose of 3-chloro-1,2-propanediol on the testes and epididymides of dog.
A single high dose (70 mg/kg) of 3-chloro-1,2-propanediol (alpha-chlorohydrin) caused pathological degeneration in the testes of dog when examined after 33 days. The seminiferous tubules were depleted of spermatogenic elements. Epididymal epithelium was regressed, the lumen was empty and the passage through the duct was unimpaired. Alpha-chlorohydrin inhibited the synthesis of RNA and sialic acid of the testes and epididymides. A single high dose of alpha-chlorohydrin increased the total cholesterol/g of wet testis tissue which could be correlated with the testicular atrophy. Antiandrogenic nature of the compound has been discussed.
D000818:Animals; D002728:Chlorohydrins / Q000494:pharmacology*; D002784:Cholesterol / Q000378:metabolism; D004285:Dogs; D004822:Epididymis / Q000187:drug effects*; D007985:Leydig Cells / Q000187:drug effects; D008297:Male; D012313:RNA / Q000096:biosynthesis; D012794:Sialic Acids / Q000096:biosynthesis; D013093:Spermatogonia / Q000187:drug effects; D013245:Sterilization, Reproductive / Q000379:methods*; D013737:Testis / Q000187:drug effects* / Q000378:metabolism; D014649:Vas Deferens / Q000187:drug effects; D000517:alpha-Chlorohydrin / Q000494:pharmacology*
D002728:Chlorohydrins; D012794:Sialic Acids; D012313:RNA; D000517:alpha-Chlorohydrin; D002784:Cholesterol