Topical lidocaine in treatment of cerebral vasospasm.
Relief of segmental spasm in monkeys was obtained using topical lidocaine after experimental subarachnoid hemorrhage. Dilatation of spastic vessels was also observed in patients following lidocaine application during operations. The segments of arteries approximating the clipped aneurysm were noted to be dilated angiographically in certain cases.
D000287:Administration, Topical; D000818:Animals; D006801:Humans; D002532:Intracranial Aneurysm / Q000601:surgery; D002546:Ischemic Attack, Transient / Q000188:drug therapy* / Q000209:etiology; D008012:Lidocaine / Q000008:administration & dosage* / Q000627:therapeutic use; D008253:Macaca mulatta; D011183:Postoperative Complications
D008012:Lidocaine