Deoxycorticosterone-adenine interactions in a crystalline complex.
Deoxycorticosterone-adenine monohydrate is the first complex involving a steroid and a component of DNA to be successfully crystallized and studied by single crystal x-ray analysis. Hydrogen bonds between O(20) and N(6) as well as O(21) and N(1) connect the corticoid side chain to an adenine molecule. The molecules are also packed such that a second adenine moiety is situated over the delta4-3-one region of the steroid. These observations of the solid state suggest ways in which steroids and nucleic acids may interact in vivo.
D000225:Adenine; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D003461:Crystallography; D003900:Desoxycorticosterone; D006860:Hydrogen Bonding; D014961:X-Ray Diffraction
D003900:Desoxycorticosterone; D000225:Adenine