Pathologic findings and laboratory data in a new strain of obese hypertensive rats.
A new strain of rat characterized by genetic obesity, endogenous hyperlipidemia, and hypertension was obtained in this laboratory.  The abnormal phenotype is inherited as a homozygous recessive trait.  The animals exhibit marked hypertriglyceridemia, moderate hypercholesterolemia, and an electrophoretic pattern resembling that of human Type IV hyperlipoproteinemia.  The average life-span is less than 1 year, due largely to the development of premature renal and vascular disease.  The kidney lesion has both glomerulonephritic and nephrosclerotic components and is accompanied by marked proteinuria.  About 12% of animals develop urinary tract calculi.  The vascular disease consists of fibrous and fatty-fibrous intimal plaques, and polyarteritis.  The obese animal offers a useful model for investigating abnormal lipid metabolism and the etiology and pathogenesis of atherosclerosis.
D000311:Adrenal Glands / Q000473:pathology; D000367:Age Factors; D000818:Animals; D001786:Blood Glucose; D001835:Body Weight; D002784:Cholesterol / Q000097:blood; D005260:Female; D006029:Glycosuria; D006973:Hypertension / Q000097:blood / Q000235:genetics*; D007246:Infertility; D008297:Male; D009765:Obesity / Q000097:blood / Q000235:genetics*; D010903:Pituitary Gland, Anterior / Q000473:pathology; D011507:Proteinuria; D011704:Pyelonephritis; D051381:Rats; D012737:Sex Factors; D014280:Triglycerides / Q000097:blood; D014545:Urinary Calculi
D001786:Blood Glucose; D014280:Triglycerides; D002784:Cholesterol