[Teratogenic effect of busulfan on testis cells of the rat (postnatal development)].
10-mg/kg of 1,4-bis-(methanesulfonyloxy)-butane (busulfan) are administered on various days of gestation to Wistar rats. The testes of the male pubs of these litters are examined histologically. Depending on the time of application of busulfan the cells of spermiogenesis are dimished and the meiosis is delayed. The Leydig cells are unchanged. In a second experiment, the weight of the seminal vesicles, LH and FSH in the serum show no differences versus the control group.
D000704:Analysis of Variance; D000818:Animals; D002066:Busulfan / Q000009:adverse effects*; D002452:Cell Count; D005260:Female; D005640:Follicle Stimulating Hormone / Q000097:blood; D005865:Gestational Age; D007985:Leydig Cells / Q000187:drug effects; D007986:Luteinizing Hormone / Q000097:blood; D008297:Male; D008431:Maternal-Fetal Exchange; D008540:Meiosis / Q000187:drug effects; D009929:Organ Size / Q000187:drug effects; D011247:Pregnancy; D051381:Rats; D012669:Seminal Vesicles / Q000187:drug effects; D013091:Spermatogenesis / Q000187:drug effects; D013723:Teratogens / Q000494:pharmacology*; D013737:Testis / Q000166:cytology / Q000187:drug effects*
D013723:Teratogens; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone; D002066:Busulfan
Zur teratogenen Wirkung von Busulfan auf die Hodenzellen der Ratte (die postnatale Entwicklung)