Radiosensitization of a human cell line lacking repair replication.
A human cell line has been isolated that is deficient in X-ray-induced repair replication. The slope of the radiation survival curve is greater in the presence of the anthracycline antibiotic, adriamycin. The results suggest that radiosensitization by DNA-binding drugs is more probably related to DNA strand breakage phenomena than to the polymerase step of excision-repair.
D002460:Cell Line; D002470:Cell Survival / Q000528:radiation effects; D003037:Cobalt Radioisotopes; D004260:DNA Repair; D004261:DNA Replication / Q000528:radiation effects*; D004317:Doxorubicin / Q000494:pharmacology; D006367:HeLa Cells / Q000378:metabolism / Q000528:radiation effects; D006801:Humans; D011830:Radiation Effects; D013936:Thymidine / Q000378:metabolism
D003037:Cobalt Radioisotopes; D004317:Doxorubicin; D013936:Thymidine