[Radio-iodine therapy of toxic adenoma of the thyroid (author's transl)].
Between 1963 and 1971, radioiodine (133I) treatment of a toxic thyroid adenoma was performed in 229 patients, in 70% the dosage being 30000 rd. In 188 patients the results were checked an average of 2 1/2 years later. Subjective improvement or freedom from symptoms was achieved in 76% (in 85% within 3-6 months), body weight increased, serum cholesterol level rose significantly, while pulse rate, pulse amplitude, PB127I and index of free thyroid hormones significantly fell. The 131I two-phase test was inconclusive. 72% of toxic adenomas were inactivated and 88% of patients with still active adenomas were improved or free from symptoms. Clinical improvement apparently preceded the scanning results. Corresponding to the index of free thyroid hormones, 94% were euthyroid, 0.6% hyperthroid, and 2.8% suspected of being hypothryoid. In combination with other findings, especially isotope scanning, 1.7% of patients were suspected of having T3 hyperthyroidism after treatment. A recurrence was observed in 2.1%. The success rate increased with rising radiation dose up to 30000 rd.
D000236:Adenoma / Q000150:complications / Q000532:radiotherapy*; D000328:Adult; D000368:Aged; D001794:Blood Pressure; D001835:Body Weight; D002784:Cholesterol / Q000097:blood; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D006980:Hyperthyroidism / Q000150:complications; D007457:Iodine Radioisotopes / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged; D011674:Pulse; D011879:Radiotherapy Dosage; D013963:Thyroid Hormones / Q000097:blood; D013964:Thyroid Neoplasms / Q000150:complications / Q000532:radiotherapy*; D013997:Time Factors
D007457:Iodine Radioisotopes; D013963:Thyroid Hormones; D002784:Cholesterol
Radiojodtherapie des autonomen Adenoms