Endotoxinaemia and the pathogenesis of acute renal failure.
A study has been made by Limulus assay of the incidence of endotoxinaemia in renal disease: positive results were found in 12/16 patients at the onset of acute renal failure. Results are supported by those of a platelet nitroblue tetrazolium reduction assay. In individual cases increased fibrinogen catabolism has been linked to substantial endotoxin levels. The assay can evaluate endotoxinaemia as a cause of acute renal failure and also detect secondary infection. Shwartzman equivalents appear to account for most cases of acute renal failure in man.
D058186:Acute Kidney Injury / Q000209:etiology*; D000368:Aged; D001792:Blood Platelets; D002779:Cholestasis / Q000150:complications; D004238:Diverticulitis / Q000150:complications; D004731:Endotoxins / Q000097:blood*; D005260:Female; D005340:Fibrinogen / Q000378:metabolism; D006801:Humans; D007415:Intestinal Obstruction / Q000150:complications; D008297:Male; D008875:Middle Aged; D009580:Nitroblue Tetrazolium; D011704:Pyelonephritis / Q000150:complications; D012790:Shwartzman Phenomenon
D004731:Endotoxins; D009580:Nitroblue Tetrazolium; D005340:Fibrinogen