End-plate morphology in amyotrophic lateral sclerosis.
Intercostal muscle end-plates were measured in patients with amyotrophic lateral sclerosis (ALS) and more benign motor neuron disease (MND). The length of the intact end-plates in ALS and MND was not different from the controls. Segmented end-plates were increased in both ALS and benign MND, and the end-plate length was greatest in ALS. In individual ALS cases, no correlation was found between the end-plate abnormalities and relevant clinical variables.
D000328:Adult; D000368:Aged; D000690:Amyotrophic Lateral Sclerosis / Q000473:pathology*; D005260:Female; D006801:Humans; D008875:Middle Aged; D009045:Motor Endplate / Q000473:pathology*; D009468:Neuromuscular Diseases / Q000473:pathology; D009469:Neuromuscular Junction / Q000473:pathology*