Studies on absorption and elimination of drugs. Part IV. Computer evaluation of pharmacokinetic parameters of the two compartment open model.
A simple programme was written in ALGOL 1204 for the Polish digital computer ODRA 1204. It permits the fitting of the biexponential equation C = Ae-alphat+Be-betat to the observed plasma or serum concentration data of a drug after a single iv injection.
D001682:Biological Availability; D001692:Biological Transport; D001702:Biopharmaceutics; D001711:Biotransformation; D003201:Computers; D007700:Kinetics; D008433:Mathematics