Lack of effect of massive dose of vitamin C on fluoride excretion in fluorosis during a short clinical trial.
The effect of daily administration of 2 g of vitamin C on urinary excretion of fluoride in patients suffering from endemic fluorosis was studied. Urinary fluoride excretion was found to be constant over a period of 4 weeks in each patient. The results suggested that vitamin C does not influence the rate of resorption of fluorotic bone in man.
D000328:Adult; D001205:Ascorbic Acid / Q000494:pharmacology*; D001862:Bone Resorption; D004305:Dose-Response Relationship, Drug; D005458:Fluoride Poisoning / Q000188:drug therapy / Q000378:metabolism*; D005459:Fluorides / Q000378:metabolism*; D006801:Humans; D007194:India; D008297:Male; D008875:Middle Aged
D001205:Ascorbic Acid; D005459:Fluorides