[Adrenoceptors and autonomic nerve control mechanisms in the biliary tract].
Effects of sympathomimetics and sympatholitics were studied on the biliary system of guinea-pigs (in vitro) and rabbits (in vitro and in vivo). Contractions and relaxations produced by sympathomimetic amines are mediated by alpha-excitatory and beta-inhibitoray adrenoceptors in the biliary system (gallbladder, common bile duct and sphinctor of oddi) of guinea-pigs. Sympathomimetic amines caused relaxations in the sphincter of oddi in rabbits (in vitro and in vivo) and responses were antagonized by alpha- and beta-blockade or a combination of both. Sympathomimetic amines caused contraction and relaxation on the common bile duct of rabbits. Transmural stimulation to guinea-pig gallbladder and rabbit common bile duct is mediated by cholinergic and adrenergic nerves, alpha-inhibitory adrenoceptor would thus be involved in the postanglionic cholinergic nerve endings in the gallbladder of guinea-pig. No difference was observed in mechanical responses to transmural stimulation in either the isolated sphincter of oddi or the duodenum of rabbits. It is concluded that the guinea-pig biliary system is functionally independent of the gastro-intestinal system and that the rabbit sphincter of oddi is functionally similar to the duodenal wall.
D000818:Animals; D001285:Atropine / Q000494:pharmacology; D001659:Biliary Tract / Q000187:drug effects / Q000502:physiology*; D003135:Common Bile Duct / Q000187:drug effects / Q000502:physiology; D003983:Dibenzylchlorethamine / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D004837:Epinephrine / Q000494:pharmacology; D005704:Gallbladder / Q000187:drug effects / Q000502:physiology; D006168:Guinea Pigs; D006584:Hexamethonium Compounds / Q000494:pharmacology; D066298:In Vitro Techniques; D007545:Isoproterenol / Q000494:pharmacology; D008297:Male; D009119:Muscle Contraction / Q000187:drug effects; D009130:Muscle, Smooth / Q000187:drug effects / Q000502:physiology; D009538:Nicotine / Q000494:pharmacology; D009638:Norepinephrine / Q000494:pharmacology; D010646:Phentolamine / Q000494:pharmacology; D010656:Phenylephrine / Q000494:pharmacology; D010812:Physical Stimulation; D011433:Propranolol / Q000494:pharmacology; D011817:Rabbits; D011941:Receptors, Adrenergic / Q000187:drug effects*; D012701:Serotonin / Q000494:pharmacology; D009803:Sphincter of Oddi / Q000187:drug effects / Q000502:physiology; D013565:Sympatholytics / Q000494:pharmacology*; D013566:Sympathomimetics / Q000494:pharmacology*; D013779:Tetrodotoxin / Q000494:pharmacology; D014043:Tolazoline / Q000494:pharmacology; D014439:Tyramine / Q000494:pharmacology
D006584:Hexamethonium Compounds; D011941:Receptors, Adrenergic; D013565:Sympatholytics; D013566:Sympathomimetics; D010656:Phenylephrine; D012701:Serotonin; D013779:Tetrodotoxin; D003983:Dibenzylchlorethamine; D009538:Nicotine; D001285:Atropine; D011433:Propranolol; D014043:Tolazoline; D007545:Isoproterenol; D009638:Norepinephrine; D014439:Tyramine; D004837:Epinephrine; D010646:Phentolamine