[Proceedings: Peroxydase activity in benign thyroid diseases and in experimental rat goiters (author's transl)].
Peroxydase activity in various benign thyroid diseases has been investigated. In hyperthyroid patients treated with antithyroid drugs, the observed increase in iodide-peroxydase activity (7 times that of normal tissue) is double than that of the DNA content. In goiter, the activity is 3 times that of normal tissue while the DNA content is unchanged. These results are in agreement with those obtained in rats maintained on a low iodine diet suggesting that high cellular enzymatic activity is due to specific enzyme induction in excess of cell proliferation and protein synthesis.
D000818:Animals; D006042:Goiter / Q000201:enzymology; D006801:Humans; D006980:Hyperthyroidism / Q000188:drug therapy; D066298:In Vitro Techniques; D007453:Iodide Peroxidase / Q000032:analysis*; D007454:Iodides / Q000378:metabolism; D007455:Iodine / Q000172:deficiency; D010544:Peroxidases / Q000032:analysis*; D051381:Rats; D013959:Thyroid Diseases / Q000201:enzymology*; D013961:Thyroid Gland / Q000201:enzymology*
D007454:Iodides; D007455:Iodine; D010544:Peroxidases; D007453:Iodide Peroxidase
Activité peroxydasique de thyroïdes humaines dans les affections thyroïdiennes bénignes et dans les goitres expérimentaux chez le rat