[Anti-inflammatory properties of some immunodepressants].
As evidenced from experiments conducted on rats immunodepressants-antimetabolites 6-mercaptopurine, methotrexate and 5-fluoruracil exert an antiexudative action and inhibit inflammation in its proliferative phase, as well as significantly change the count of leucocytes and their formula in the peripheral blood. It was established that the anti-exudate properties of these compounds may not be related to their immunodepressive action, while inhibition of proliferation is occasioned by their specific cytostatic effect.
D000362:Agar; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology*; D001773:Blood Cells / Q000187:drug effects; D001808:Blood Vessels / Q000187:drug effects; D003911:Dextrans; D005122:Exudates and Transudates / Q000187:drug effects; D005260:Female; D005472:Fluorouracil / Q000494:pharmacology; D006097:Granulation Tissue / Q000187:drug effects; D006632:Histamine; D007165:Immunosuppression Therapy; D007166:Immunosuppressive Agents / Q000494:pharmacology*; D007249:Inflammation / Q000139:chemically induced; D007958:Leukocyte Count; D007970:Leukopenia / Q000139:chemically induced; D008297:Male; D015122:Mercaptopurine / Q000494:pharmacology; D008727:Methotrexate / Q000494:pharmacology; D051381:Rats; D012701:Serotonin; D013997:Time Factors; D014992:Xylenes / Q000494:pharmacology
D000893:Anti-Inflammatory Agents; D003911:Dextrans; D007166:Immunosuppressive Agents; D014992:Xylenes; D012701:Serotonin; D006632:Histamine; D000362:Agar; D015122:Mercaptopurine; D005472:Fluorouracil; D008727:Methotrexate
Protivovospalitel'nye svoĭstva nekotorykh immunodepressantov