[The saluretic effect of xipamide (4-chloro-5-sulfamoyl-2',6'-salicyloxylilide) in normal subjects].
The diuretic and saluretic effectiveness of xipamide (4-chloro-5-sulfamoyl-2',6'-salicyloxylidide, Aquaphor) is determined and compared to those of chlortalidone and furosemid in normal subjects. The substance is revealed as a potent diuretic agent. In the range of 0.035--0.750 mg/kg body weight the dose-response curve of orally administered xipamide for the increase of excretion of urine, sodium and potassium ion and chloride during 24 h is described. Observing the renal activity over a period of 3 days after a single administration the duration of action is found to be up to 24 h with its maximum within the first 12 h. In the following 2 days the degree of the physiological rebound effect depends on the preceding saluretic effect and thus on the given dose. The pattern of ion-excretion (Na
D000284:Administration, Oral; D000328:Adult; D002712:Chlorides / Q000652:urine; D002752:Chlorthalidone / Q000494:pharmacology; D004231:Diuresis / Q000187:drug effects; D004232:Diuretics / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D004341:Drug Evaluation; D005665:Furosemide / Q000494:pharmacology; D006801:Humans; D008297:Male; D008875:Middle Aged; D009318:Natriuresis / Q000187:drug effects*; D011188:Potassium / Q000652:urine; D012457:Salicylamides / Q000494:pharmacology; D012964:Sodium / Q000652:urine; D013997:Time Factors; D014992:Xylenes / Q000032:analysis / Q000494:pharmacology
D002712:Chlorides; D004232:Diuretics; D012457:Salicylamides; D014992:Xylenes; D005665:Furosemide; D012964:Sodium; D002752:Chlorthalidone; D011188:Potassium
Die saluretische Wirkung von Xipamid (4-Chlor-5-sulfamoyl-2',6'-salicyloxylidid) bei gesunden Probanden