Serum, renal, and urinary lysozyme levels after hypohysectomy.
Hypophysectomy is known to cause a rise in the renal lysozyme levels and atrophy of the proximal tubules of the kidney. The present study describes the relationship of serum, urinary, and renal lysozyme levels in hypophysectiomized animals. The renal lysozyme level continued to rise during the first 4 weeks after hypophysectomy and then remained constant while the serum level increased immediately after hypophysectomy and plateaued. Hypophysectomy did not produce lysozymuria for the time periods used in these experiments despite obvious tubular atrophy by the end of the 1st week after hypophysectomy. These data suggest that tubular atrophy must progress to a severe stage before a lysozymuria is produced. Thus the absence of urinary lysozyme activity does not exclude the possibility of proximal tubule injury.
D000818:Animals; D007016:Hypophysectomy; D007668:Kidney / Q000201:enzymology*; D007683:Kidney Tubular Necrosis, Acute / Q000201:enzymology / Q000473:pathology; D007687:Kidney Tubules, Proximal / Q000648:ultrastructure; D008297:Male; D009113:Muramidase / Q000097:blood / Q000378:metabolism* / Q000652:urine; D051381:Rats; D013997:Time Factors
D009113:Muramidase