Effects of aprindine HCL on cardiac tissues.
The effects of aprindine HCL on cardiac tissues were studied in anesthetized, open-chest dogs pretreated with atropine (0.8 mg/kg) and propranolol (1.0 mg/kg). Aprindine (10(-5)-10(-3) g/ml), injected into the sinus node artery, decreased the spontaneous sinus rate; when injected into the atrioventricular nodal artery, aprindine (10(-4) g/ml) prolonged the conduction time and functional refractory period of the atrioventricular node. Intravenous administration of aprindine (1.4, 2.8 and 4.2 mg/kg cumulative dose) prolonged atrial and ventricular conduction time and prolonged the effective refractory period of both tissues. The results from this study indicate that aprindine has a negative dromotropic effect on all cardiac tissue.
D000818:Animals; D001073:Aprindine / Q000494:pharmacology*; D016275:Atrial Function; D001283:Atrioventricular Node / Q000187:drug effects; D004285:Dogs; D004558:Electric Stimulation; D005260:Female; D006321:Heart / Q000187:drug effects* / Q000502:physiology; D006329:Heart Conduction System / Q000187:drug effects; D007192:Indenes / Q000494:pharmacology*; D008297:Male; D012032:Refractory Period, Electrophysiological / Q000187:drug effects; D013997:Time Factors; D016276:Ventricular Function
D007192:Indenes; D001073:Aprindine