Effects of sulfadimethoxine on tissue distribution of (14C)bilirubin in the newborn and adult hyperbilirubinemic Gunn rate.
Sulfadimethoxine significantly reduced plasma bilirubin levels and altered the tissue bilirubin distribution in both the newborn and the adult Gunn rat. The majority of the unbound bilirubin appeared to distribute perferentially to the intestine and liver in the newborn, whereas in the adult the unbound bilirubin was taken up primarily by the liver. The bilirubin content of brain tissue from both age groups was significantly higher after sulfadimethoxine treatment.
D000818:Animals; D000831:Animals, Newborn / Q000378:metabolism*; D001663:Bilirubin / Q000378:metabolism*; D001921:Brain / Q000378:metabolism; D004064:Digestive System / Q000378:metabolism; D005260:Female; D006801:Humans; D006932:Hyperbilirubinemia / Q000378:metabolism*; D008099:Liver / Q000378:metabolism; D008297:Male; D051381:Rats; D013412:Sulfadimethoxine / Q000494:pharmacology*
D013412:Sulfadimethoxine; D001663:Bilirubin