Synthesis and cytotoxicity of 6-selenopurine arabinoside and related compounds.
6-Chloro-9-(beta-D-arabinofuranosyl)purine served as an intermediate for the chemical synthesis of a series of 6-substituted selenopurine arabinosides. In an in vitro test using murine leukemic cells (L-5178Y) these 6-substituted selenopurine arabinosides showed some cytotoxicity. Lengthening the side chain had no effect on their cytotoxicity. Selenourea was a useful reagent for synthesizing selenopurines, selenopurine nucleosides, and selenopurine arabinoside under mild conditions.
D000818:Animals; D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000494:pharmacology; D002478:Cells, Cultured; D007942:Leukemia, Experimental; D051379:Mice; D016566:Organoselenium Compounds; D011684:Purine Nucleosides / Q000138:chemical synthesis / Q000494:pharmacology; D012643:Selenium / Q000494:pharmacology; D013997:Time Factors
D000970:Antineoplastic Agents; D016566:Organoselenium Compounds; D011684:Purine Nucleosides; C010784:6-selenopurine arabinoside; D012643:Selenium