Perinatal vitamin D metabolism. II. Serial 25-hydroxyvitamin D concentrations in sera of term and premature infants.
Serial concentration values of 25-hydroxyvitamin D (25-OHD) were determined in the sera of term, premature, and twin infants. In infants born at term with normal concentrations of 25-OHD in cord blood, serial concentrations of 25-OHD remained normal; in infants born at term with low concentrations of 25-OHD in cord blood, serial concentrations of 25-OHD increased. In premature infants with normal concentrations of 25-OHD in cord blood, serial concentrations of 25-OHD decreased; in premature infants with low values of 25-OHD in cord blood, serial concentrations of 25-OHD did not increase until a postconceptual age of 36 to 38 weeks. The concentrations of 25-OHD in the sera of twin infant pairs followed parallel courses. Oral and intravenous supplementation of vitamin D did not significantly increase the concentrations of 25-OHD in serum of premature infants. These findings suggest that a decreased rate of 25-hydroxylation of vitamin D may be a factor impairing homeostasis of 25-OHD in premature infants.
D000284:Administration, Oral; D005260:Female; D006801:Humans; D006900:Hydroxylation; D007228:Infant Nutrition Disorders / Q000378:metabolism; D007227:Infant Nutritional Physiological Phenomena; D007231:Infant, Newborn; D007234:Infant, Premature; D007263:Infusions, Parenteral; D008099:Liver / Q000378:metabolism; D011247:Pregnancy; D014427:Twins; D014807:Vitamin D / Q000008:administration & dosage / Q000097:blood / Q000378:metabolism*; D014808:Vitamin D Deficiency / Q000188:drug therapy / Q000378:metabolism*
D014807:Vitamin D