[Changes in blood constituents induced by noradrenaline infusion and acute cold exposure in rats treated chronically with noradrenaline and thyroxine (author's transl)].
Rats were treated with noradrenaline (NA), thyroxine (T4), NA plus T4, and NA plus ACTH for 28 days, and changes in rectal temperature and blood concentrations of nonesterified fatty acids (NEFA), sugar, and lactate were observed following NA infusion and acute cold exposure. Results obtained were compared with those found in cold-acclimated rats. NA infusion caused a marked elevation of the rectal temperature in cold-acclimated rats and NA plus T4-treated ones. No significant changes were observed in plasma NEFA level following NA infusion in cold-acclimated and NA-treated rats. Treatment with T4 tended to augment the lipolytic action of NA. Treatment with NA plus ACTH showed similar effect of augmented lipolysis. Changes in blood sugar level induced by NA infusion were small in cold-acclimated and NA plus T4 groups. Changes in blood lactate level were not significant in NA plus ACTH group. After acute cold exposure plasma NEFA level was low in cold-acclimated rats and high in NA plus T4-treated rats. Blood sugar level was slightly higher in cold-acclimated and NA plus T4-treated rats than in the other groups. Plasma lactate level showed relatively high values in T4 and NA plus T4 groups. It was thus suggested that metabolic patterns in cold-acclimated rats and in NA plus T4- as well as NA-treated rats were somewhat alike, but not always the same.
D000064:Acclimatization / Q000187:drug effects*; D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D001831:Body Temperature / Q000187:drug effects; D003080:Cold Temperature; D005230:Fatty Acids, Nonesterified / Q000097:blood; D007263:Infusions, Parenteral; D007275:Injections, Intravenous; D007773:Lactates / Q000097:blood; D008297:Male; D009638:Norepinephrine / Q000008:administration & dosage / Q000494:pharmacology*; D051381:Rats; D013974:Thyroxine / Q000008:administration & dosage / Q000494:pharmacology*
D001786:Blood Glucose; D005230:Fatty Acids, Nonesterified; D007773:Lactates; D013974:Thyroxine; D009638:Norepinephrine