Comparison of structural and stereoisomers of apomorphine on stereotyped behavior of the rat.
N-n-propylnorapomorphine (NPA) is 35 times more potent than apomorphine (APO) in producing stereotyped behavior in rats. The effect of NPA is blocked by perphenazine but unaltered by alpha-methyltyrosine pretreatment and is accompanied by a decrease in central dopamine turnover. The activity of APO and NPA appears to be primarily in the (-)-isomer, and is diminished but not lost by removal of either hydroxyl group from the catechol ring system.
D000818:Animals; D001058:Apomorphine / Q000031:analogs & derivatives* / Q000037:antagonists & inhibitors / Q000494:pharmacology; D001519:Behavior / Q000187:drug effects*; D002395:Catecholamines / Q000378:metabolism; D004298:Dopamine / Q000378:metabolism; D006801:Humans; D007536:Isomerism; D008297:Male; D008781:Methyltyrosines / Q000494:pharmacology; D009638:Norepinephrine / Q000378:metabolism; D010546:Perphenazine / Q000494:pharmacology; D051381:Rats; D013237:Stereoisomerism; D013239:Stereotyped Behavior / Q000187:drug effects*
D002395:Catecholamines; D008781:Methyltyrosines; D010546:Perphenazine; D001058:Apomorphine; D004298:Dopamine; D009638:Norepinephrine