Effect of calcium chloride on some metabolic actions of certain antidiabetic drugs in normal and alloxanised rabbits.
Calcium chloride increased the liver insulinase activity (LIA) in normal rabbits. No significant changes were noted in the plasma insulinlike activity (PILA), serum zinc level (SZ), and pancreatic zinc content (PZ). Insulin elevated PILA, SZ and PZ but did not affect LIA. Calcium chloride enhanced the effect of insulin on PILA, SZ and PZ. However, insulin did not affect the action of calcium chloride on LIA. Tolbutamide raised PILA, inhibited both LIA and SZ but did not affect PZ. Calcium chloride produced no change in the action of tolbutamide on PILA. On the other hand, tolbutamide prevented the rise of PILA obtained by calcium chloride. PZ was unaltered with calcium chloride and tolbutamide combination. Phenformin increased PILA, LIA, SZ and PZ. When it was given with calcium chloride no further changes in PILA and PZ were observed. The elevation of SZ was abolished but the rise of LIA was synergized. In alloxanized rabbits, LIA was decreased by calcium chloride. No changes were found in PILA, SZ and PZ. Insulin elevated PILA, LIA and SZ although it reduced PZ. Calcium chloride stimulated insulin effect on PILA, did not affect its action on SZ or PZ, and antagonized its effect on LIA. Tolbutamide increased LIA and SZ but did not affect PILA or PZ. Calcium chloride could not change the effect of tolbutamide on SZ or PILA although it could abolish the action of this drug on LIA and PZ. Phenformin significantly lowered PILA, LIA and PZ but raised SZ. Calcium chloride combination with phenformin produced a further decrease in LIA but no other changes in PIAL, SZ or PZ were recorded.
D000818:Animals; D002122:Calcium Chloride / Q000494:pharmacology*; D003921:Diabetes Mellitus, Experimental / Q000378:metabolism; D004336:Drug Antagonism; D004357:Drug Synergism; D007328:Insulin / Q000097:blood / Q000494:pharmacology*; D007339:Insulysin / Q000378:metabolism; D008099:Liver / Q000201:enzymology; D008297:Male; D010179:Pancreas / Q000378:metabolism; D010629:Phenformin / Q000494:pharmacology*; D011817:Rabbits; D014044:Tolbutamide / Q000494:pharmacology*; D015032:Zinc / Q000097:blood / Q000378:metabolism
D007328:Insulin; D014044:Tolbutamide; D010629:Phenformin; D007339:Insulysin; D015032:Zinc; D002122:Calcium Chloride