[Platelet dysfunction as a result of inhibition of ADP release (aspirin-like defect) in two identical twins(author's transl)].
An abnormal release of platelet adenosine diphosphate (ADP), as seen after intake of acetylsalicylic acid, was demonstrated to be the cause of a clotting disorder in two identical female twins. The signs of bleeding occurred at the age of 26 and consisted of an increased frequency of haematomas, hypermenorrhoea not explained on gynaecological grounds, and prolonged bleeding after minor injuries. Increased bleeding time, abnormal aggregation after stimulation with collagen and absence of the second aggregation phase after addition of ADP were the abnormal findings of this clearly hereditary form of platelet dysfunction. The platelets were slightly larger than normal ones and there were changes in ultrastructure.
D000244:Adenosine Diphosphate / Q000097:blood* / Q000378:metabolism; D000328:Adult; D000367:Age Factors; D001780:Blood Coagulation Tests; D001791:Blood Platelet Disorders / Q000097:blood / Q000209:etiology / Q000235:genetics*; D001792:Blood Platelets / Q000378:metabolism; D004200:Diseases in Twins; D005260:Female; D006406:Hematoma / Q000209:etiology; D006801:Humans; D008599:Menstruation Disturbances / Q000209:etiology; D008661:Metabolism, Inborn Errors / Q000150:complications; D008854:Microscopy, Electron; D010973:Platelet Adhesiveness
D000244:Adenosine Diphosphate
Thrombozytopathie durch ADP-Freisetzungshemmung ("aspirin-like defect") bei einem eineiigen Zwillingspaar