Ameloblastic odontoma in rats induced by N-butylnitrosourea.
Four cases of ameloblastic odontomas were found in the Long-Evans rats treated with multiple oral administration of a heavy dose of N-butylnitrosourea. The tumor was found as an expansive enlargement over the mandible and was roentgen-opaque. The tumor was histologically characterized by various elements such as odontogenic epithelium, stellated reticulum tissue, enamel, and/or dentine, and was classified as ameloblastic odontoma.
D000564:Ameloblastoma / Q000139:chemically induced*; D000818:Animals; D002273:Carcinogens; D005260:Female; D008297:Male; D008339:Mandibular Neoplasms / Q000139:chemically induced*; D009374:Neoplasms, Experimental / Q000139:chemically induced; D009607:Nitrosourea Compounds; D009808:Odontogenic Tumors / Q000139:chemically induced*; D051381:Rats
D002273:Carcinogens; D009607:Nitrosourea Compounds