Deamination of biogenic amines and other nitrogenous compounds in granulation tissue from experimental wounds.
In the granulation tissue of skin wounds an increase in the content of hydroxyproline was accompanied by changes in lipid peroxidation products. At the same time deamination of 5-hydroxytryptamine, tyramine or adenosine-5'-monophosphate decreased, but the ability to deaminate histamine, putrescine and lysine appeared. Pargyline prevented the appearance of these new deaminating properties. Adenosine-3'-monophosphate slowed down to the weight increase and lowered the content of hydroxyproline in the growing granulation tissue; it also changed the dynamics of deamination of tyramine or 5-hydroxytryptamine and significantly inhibited the deamination of histamine, lysine and adenosine-5'-monophosphate. The patterns of changes in deamination of nitrogenous compounds and the effects caused by pargyline and adenosine-3'-monophosphate suggest that qualitative alteration (transformation) in catalytic properties of monoamine oxidases may occur in the growing granulation tissue from wounds.
D000249:Adenosine Monophosphate / Q000378:metabolism / Q000494:pharmacology; D000818:Animals; D001679:Biogenic Amines / Q000378:metabolism*; D003641:Deamination; D003864:Depression, Chemical; D006097:Granulation Tissue / Q000201:enzymology / Q000378:metabolism*; D006632:Histamine / Q000378:metabolism; D006909:Hydroxyproline / Q000378:metabolism; D050356:Lipid Metabolism; D008239:Lysine / Q000378:metabolism; D008297:Male; D008995:Monoamine Oxidase / Q000378:metabolism; D010293:Pargyline / Q000494:pharmacology; D051381:Rats; D012701:Serotonin / Q000378:metabolism; D012867:Skin / Q000293:injuries*; D013268:Stimulation, Chemical; D014439:Tyramine / Q000378:metabolism
D001679:Biogenic Amines; D012701:Serotonin; D000249:Adenosine Monophosphate; D006632:Histamine; D010293:Pargyline; D008995:Monoamine Oxidase; D008239:Lysine; D006909:Hydroxyproline; D014439:Tyramine