Effect of human plasma lipase on smooth muscle.
In the presence of serum albumin, the enzyme human plasma lipase produces a slow contraction of smooth muscle. This effect was not antagonized by antazoline or by atropine, and was completely abolished by heating the enzyme prepartion for 1 min at 60 degrees C. Calcium ions were found to potentiate the effect of plasma lipase on smooth muscle.
D000818:Animals; D000865:Antazoline / Q000494:pharmacology; D001285:Atropine / Q000494:pharmacology; D002118:Calcium / Q000494:pharmacology; D006168:Guinea Pigs; D006358:Hot Temperature; D006801:Humans; D007082:Ileum / Q000187:drug effects; D066298:In Vitro Techniques; D008049:Lipase / Q000097:blood / Q000494:pharmacology*; D009119:Muscle Contraction / Q000187:drug effects; D009130:Muscle, Smooth / Q000187:drug effects*; D011489:Protein Denaturation; D012709:Serum Albumin
D012709:Serum Albumin; D001285:Atropine; D000865:Antazoline; D008049:Lipase; D002118:Calcium