Pulmonary response to polyurethane dust.
Weanling and 9 months or older rats were exposed to particles of an aged (PUF I) or freshly prepared (PUF II) rigid polyurethane foam by intratracheal intubation. The dose was 5 mg of particles. The response of the lung tissue was examined morphologically by serial sacrifices. Inflammation and macrophage activity were the initial responses. Fibrosis developed after 6 months. Nodular scars and perifocal emphysema were seen after 12 months. Four rats had a papillary adenoma in a major bronchus after 18 months exposure to PUF II.
D000367:Age Factors; D000818:Animals; D001984:Bronchial Neoplasms / Q000139:chemically induced; D003537:Cystadenoma / Q000139:chemically induced; D004391:Dust; D004781:Environmental Exposure; D005260:Female; D007442:Intubation, Intratracheal; D008168:Lung / Q000648:ultrastructure; D008171:Lung Diseases / Q000139:chemically induced*; D008175:Lung Neoplasms / Q000139:chemically induced; D008214:Lymphocytes / Q000187:drug effects; D008264:Macrophages / Q000187:drug effects; D008297:Male; D010316:Particle Size; D011140:Polyurethanes / Q000008:administration & dosage / Q000633:toxicity*; D011656:Pulmonary Emphysema / Q000139:chemically induced; D011658:Pulmonary Fibrosis / Q000139:chemically induced; D051381:Rats
D004391:Dust; D011140:Polyurethanes