Cholinergic compounds. V - New synthesis and further pharmacological evaluation of desethermuscarine.
Two new methods of syntesis of (+/-)-desethermuscarine (I) are reported along with the pharmacological evaluation of (I) extended to several muscarinic and nicotinic receptors.
D000818:Animals; D001001:Anura; D055598:Chemical Phenomena; D002621:Chemistry; D003517:Cyclopentanes / Q000138:chemical synthesis* / Q000494:pharmacology; D004353:Drug Evaluation, Preclinical; D006168:Guinea Pigs; D006321:Heart / Q000187:drug effects; D007082:Ileum / Q000187:drug effects; D007583:Jejunum / Q000187:drug effects; D010277:Parasympathomimetics / Q000138:chemical synthesis* / Q000494:pharmacology; D000644:Quaternary Ammonium Compounds / Q000138:chemical synthesis* / Q000494:pharmacology; D051381:Rats; D011950:Receptors, Cholinergic / Q000187:drug effects
D003517:Cyclopentanes; D010277:Parasympathomimetics; D000644:Quaternary Ammonium Compounds; D011950:Receptors, Cholinergic