[The influence of volatile anaesthetics on drug metabolism in the liver (author's transl)].
In Vitro experiments with rat liver microsomes (difference spectra, p-nitroanisol-demethylation) and in vivo experiments with rats (tritium release from 3H-mestranol) suggest an inhibition of the metabolism of certain drugs (type-1-substrates) by competition for the binding site of cytochrome P-450 under anaesthesia with diethyl ether, halothane, enflurane and methoxyflurane.
D000777:Anesthetics / Q000494:pharmacology*; D000818:Animals; D001665:Binding Sites / Q000187:drug effects; D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism; D004737:Enflurane / Q000494:pharmacology; D006221:Halothane / Q000494:pharmacology; D008099:Liver / Q000166:cytology; D008733:Methoxyflurane / Q000494:pharmacology; D008862:Microsomes, Liver / Q000187:drug effects* / Q000378:metabolism; D051381:Rats
D000777:Anesthetics; D008733:Methoxyflurane; D003577:Cytochrome P-450 Enzyme System; D004737:Enflurane; D006221:Halothane
Der Einfluss flüchtiger Narkosemittel auf den Fremdstoffabbau in der Leber