Combined cancer chemotherapy with cyclophoshamide and an inducer of microsomal drug-metabolizing enzymes (cytochrome P-450) in tumor-bearing rats.
The fifty percent alive period in Yoshida sarcoma-bearing and AH66F-bearing rats was prolonged by an administration in a single dose of 100 mg cyclophosphamide/kg body weight in a group pretreated with phenobarbital as compared with that pretreated with saline. However, there was little difference in fifty percent alive period between AH109A (insensitive to cyclophosphamide)-bearing rats and controls even when they were pretreated with phenobarbital. In chemotherapy with anti-cancer drugs, inductive or inhibitory effects of the drugs on microsomal drug-metabolizing enzymes should be taken into consideration.
D000818:Animals; D002701:Chloramphenicol / Q000008:administration & dosage* / Q000627:therapeutic use; D003520:Cyclophosphamide / Q000008:administration & dosage* / Q000627:therapeutic use; D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism*; D004359:Drug Therapy, Combination; D008297:Male; D008861:Microsomes / Q000201:enzymology; D009374:Neoplasms, Experimental / Q000188:drug therapy*; D010634:Phenobarbital / Q000008:administration & dosage* / Q000627:therapeutic use; D051381:Rats; D012517:Sarcoma, Yoshida / Q000188:drug therapy / Q000401:mortality
D002701:Chloramphenicol; D003520:Cyclophosphamide; D003577:Cytochrome P-450 Enzyme System; D010634:Phenobarbital