Effect of hydroxylamine on the consequences of long-lasting administration of morphine in mice. III. Effect on preferred drinking of morphine solution.
C57BL/6J mice were periodically required to drink a morphine solution for one, ten or sixteen weeks and then injected intracranially with the mutagens hydroxylamine or sodium nitrite. Whereas before the injection of the drugs the mice demonstrated a definite preference for morphine, after hydroxylamine this preference disappeared. Sodium nitrite had no such effect on the consumption of morphine solution.
D000818:Animals; D002755:Choice Behavior / Q000187:drug effects; D004327:Drinking Behavior / Q000187:drug effects; D006898:Hydroxylamines / Q000494:pharmacology*; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D009020:Morphine / Q000494:pharmacology*; D009573:Nitrites / Q000494:pharmacology; D013997:Time Factors
D006898:Hydroxylamines; D009573:Nitrites; D009020:Morphine