Time-dependent effects of phenothiazines on dopamine turnover in psychiatric patients.
Psychiatric patients studied early during treatment with chlorpromazine and thioridazine demonstrated elevated probenecid-induced accumulations of homovanillic acid, a major dopamine metabolite, in cerebrospinal fluid. In those studied after longer periods of treatment with phenothiazines, homovanillic acid values were not elevated. This suggests that there are time-dependent effects of phenothiazines on dopamine turn-over that may be relevant to the time course of antipsychotic efficacy.
D001714:Bipolar Disorder / Q000188:drug therapy; D001921:Brain / Q000187:drug effects* / Q000378:metabolism; D002746:Chlorpromazine / Q000494:pharmacology / Q000627:therapeutic use*; D004298:Dopamine / Q000378:metabolism*; D006719:Homovanillic Acid / Q000134:cerebrospinal fluid; D006801:Humans; D012559:Schizophrenia / Q000188:drug therapy; D013881:Thioridazine / Q000494:pharmacology / Q000627:therapeutic use*
D013881:Thioridazine; D002746:Chlorpromazine; D004298:Dopamine; D006719:Homovanillic Acid