Effects of xylazine and acetylpromazine upon induced ventricular fibrillation in dogs anesthetized with thiamylal and halothane.
Ventricular arryhythmias including ventricular fibrillation were produced with epinephrine in dogs induced to an anesthetic state with thiamylal and maintained with halothane. In dogs given (premedicated) xylazine 20 minutes prior to anesthesia, ventricular arrhythmias, including ventricular fibrillation, were induced with much smaller doses of epinephrine than in nonpremedicated dogs. Dogs premedicated with acetylpromazine 20 minutes prior to anesthesia with thiamylal and halothane displayed protection from epinephrine-induced arrhythmias. Caution is advised from using xylazine in the presence of halothane if epinephrine is to be administered.
D000758:Anesthesia / Q000009:adverse effects / Q000662:veterinary*; D000769:Anesthesia, Inhalation / Q000662:veterinary; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D004283:Dog Diseases / Q000139:chemically induced*; D004285:Dogs; D004837:Epinephrine / Q000494:pharmacology; D005260:Female; D006221:Halothane / Q000009:adverse effects*; D006339:Heart Rate; D008297:Male; D011395:Promazine / Q000031:analogs & derivatives* / Q000494:pharmacology; D013840:Thiamylal / Q000009:adverse effects*; D013843:Thiazines / Q000494:pharmacology*; D014693:Ventricular Fibrillation / Q000139:chemically induced / Q000662:veterinary*; D014991:Xylazine / Q000494:pharmacology*
D013843:Thiazines; D013840:Thiamylal; D014991:Xylazine; D011395:Promazine; D006221:Halothane; D004837:Epinephrine