Effect of folic acid and methotrexate on reproduction of Rauscher leukemia virus.
Folic acid was found to stimulate and its structural analog methotrexate was found to inhibit the reproduction of an oncogenic RNA-containing virus in tissue culture.
D000818:Animals; D002460:Cell Line; D003864:Depression, Chemical; D004622:Embryo, Mammalian; D005492:Folic Acid / Q000494:pharmacology*; D008727:Methotrexate / Q000494:pharmacology*; D051379:Mice; D008807:Mice, Inbred BALB C; D011925:Rauscher Virus / Q000187:drug effects*; D013268:Stimulation, Chemical; D014779:Virus Replication / Q000187:drug effects*
D005492:Folic Acid; D008727:Methotrexate