[Raising the sensitivity threshold of the hypothalamohypophyseal system to the homeostatic action of estrogens in rats with transplanted tumors].
Daily injections of 0.57 mKg of diethylstylboestrol-propionate in hemicastrated female rats inhibited the compensatory ovarian hypertrophy in control animals by 50%, and in rats with transplanted homologous fat-muscular tissue--by 4-%. In animals with subcutaneously transplanted Walker carcinoma-256, sarcome-45 and Pliss lymphosarcome this effect of estrogens was not manifested at all. The data obtained appear to evidence an increased threshold of sensitivity of the hypothalamol-hypophyseal system to a suppressing effect of estrogens in animals during the process of growth of transplantable tumors.
D000222:Adaptation, Physiological / Q000187:drug effects; D000818:Animals; D002279:Carcinoma 256, Walker / Q000503:physiopathology; D003864:Depression, Chemical; D004054:Diethylstilbestrol / Q000494:pharmacology; D004967:Estrogens / Q000494:pharmacology*; D005260:Female; D006706:Homeostasis / Q000187:drug effects*; D007030:Hypothalamo-Hypophyseal System / Q000187:drug effects*; D008228:Lymphoma, Non-Hodgkin / Q000503:physiopathology; D009368:Neoplasm Transplantation; D009374:Neoplasms, Experimental / Q000503:physiopathology*; D010053:Ovary / Q000502:physiology; D051381:Rats; D012513:Sarcoma, Experimental / Q000503:physiopathology; D013997:Time Factors
D004967:Estrogens; D004054:Diethylstilbestrol
Povyshenie poroga chuvstvitel'nosti gipotalamo-gipofizarnoĭ sistemy k gomeostaticheshomu deĭstviiu éstrogenov u krys s perevivnymi opukholiami