Serotonin metabolism is pellagra.
Altered mental status is common in pellagrins. We evaluated the mental status of pellagrins in relation to the neurohormone, serotonin or 5-hydroxytryptamine (5-HT). Levels of 5-hydroxyindoleacetic acid (5-HIAA), an end product of serotonin in the urine and cerebrospinal fluid (CSF), and of platelet 5-HT were determined in a group of pellagrins and in normal subjects. The results indicated that the 5-HT concentration was reduced in platelets and 5-HIAA excretion in urine was below normal levels. The 5-HIAA concentration in CSF was also reduced, suggesting a decrease in 5-HT functional activity in the brain.
D000328:Adult; D001792:Blood Platelets / Q000378:metabolism; D001921:Brain / Q000378:metabolism; D005260:Female; D006801:Humans; D006897:Hydroxyindoleacetic Acid / Q000652:urine; D008297:Male; D008606:Mental Processes; D008875:Middle Aged; D009539:Nicotinic Acids / Q000627:therapeutic use; D010383:Pellagra / Q000188:drug therapy / Q000378:metabolism*; D012701:Serotonin / Q000097:blood / Q000134:cerebrospinal fluid / Q000378:metabolism*
D009539:Nicotinic Acids; D012701:Serotonin; D006897:Hydroxyindoleacetic Acid