Effect of oral antidiabetic drugs on lipase activity in vitro.
Phenformin and metformin have a stimulating effect on lipolysis as determined by the action of mouse pancreas lipase on the dilauric (dido-decanoic) acid ester of fluorescein. Tolbutamide and chlorpropamide have an inhibitory effect.
D000818:Animals; D001645:Biguanides / Q000494:pharmacology; D007004:Hypoglycemic Agents / Q000494:pharmacology*; D066298:In Vitro Techniques; D008049:Lipase / Q000378:metabolism*; D051379:Mice; D010179:Pancreas / Q000201:enzymology; D013268:Stimulation, Chemical; D013453:Sulfonylurea Compounds / Q000494:pharmacology
D001645:Biguanides; D007004:Hypoglycemic Agents; D013453:Sulfonylurea Compounds; D008049:Lipase