[Isoxazoles substituted with 4-pyridyl and o-chlorophenyl radicals].
By reaction of suitable hydroxamic acids chlorides with beta-ketoesters, we have prepared the ethyl esters of isoxazol-4-carboxylic acids, substituted in the 3- and 5-positions with 4-pyridyl and o-chlorophenyl groups, and some of their esters and amides of pharmaceutical interest. 3-(4-Pyridyl)-5-(o-chlorophenyl)isoxazole was obtained either by decarboxylation of the acid or by oxidation of the syn and anti oximes of 3-(o-chlorophenyl)-1-(4-pyridyl)-2-propen-1-one; from the syn oxime the corresponding isoxazoline was also obtained. Pharmacological screening shows that some of the new compounds have a myolytic activity.
D000818:Animals; D000927:Anticonvulsants / Q000138:chemical synthesis; D002722:Chlorobenzenes / Q000138:chemical synthesis / Q000494:pharmacology; D004353:Drug Evaluation, Preclinical; D007555:Isoxazoles / Q000138:chemical synthesis* / Q000494:pharmacology; D008297:Male; D009132:Muscles / Q000187:drug effects; D010080:Oxazoles / Q000138:chemical synthesis*; D011725:Pyridines / Q000138:chemical synthesis / Q000494:pharmacology; D051381:Rats
D000927:Anticonvulsants; D002722:Chlorobenzenes; D007555:Isoxazoles; D010080:Oxazoles; D011725:Pyridines
Isossazoli sostituiti con i radicali 4-piridilico ed o-clorofenilico