Self-administration of amphetamine analogues in rats.
In rats self-injecting amphetamine (0.25 mg/kg/injection) at a stable level during daily 3 hr sessions, three different amphetamine analogues )phenmetrazine, diethylpropion and fenfluramine) were substituted for amphetamine, one at a time on different experimental days. Phenmetrazine (1.0 mg/kg/injection) and diethylpropion (2.0 mg/kg/injection) were self-administered but not fenfluramine (in doses of 0.1, 0.5 and 2.0 mg/kg/injection). It is concluded that amphetamine, phenmetrazine and diethylpropion have reinforcing properties, whereas fenfluramine has not.
D000661:Amphetamine / Q000008:administration & dosage / Q000494:pharmacology*; D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects*; D003216:Conditioning, Operant / Q000187:drug effects*; D004053:Diethylpropion / Q000008:administration & dosage / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D005277:Fenfluramine / Q000008:administration & dosage / Q000494:pharmacology*; D006801:Humans; D007275:Injections, Intravenous; D008297:Male; D008954:Models, Biological; D010633:Phenmetrazine / Q000008:administration & dosage / Q000494:pharmacology*; D051381:Rats; D012054:Reinforcement, Psychology; D019966:Substance-Related Disorders; D013997:Time Factors
D005277:Fenfluramine; D000661:Amphetamine; D004053:Diethylpropion; D010633:Phenmetrazine