Partial selectivity of 6-OHDA induced neuronal degeneration after intraissular injection in the brain with special reference to the nigro-striatal dopamine system.
The selectivity of 6-OHDA induced neuronal degeneration after intra-tissular injection in the brain is discussed considering the morphological and biochemical events occurring in the substantia nigra and in the striatum--after intranigral or intrastriatal application of the drug. The data suggest that a critical intratissular concentration of 6-OHDA is required to induce an elective neuronal degeneration. The importance of the non-specific damage can not be neglected when high doses of the drug are administered in the brain tissue.
D000818:Animals; D002794:Choline / Q000378:metabolism; D003342:Corpus Striatum / Q000187:drug effects* / Q000378:metabolism; D004298:Dopamine / Q000378:metabolism*; D006892:Hydroxydopamines / Q000494:pharmacology*; D009410:Nerve Degeneration / Q000187:drug effects*; D012701:Serotonin / Q000378:metabolism; D013378:Substantia Nigra / Q000187:drug effects* / Q000378:metabolism
D006892:Hydroxydopamines; D012701:Serotonin; D002794:Choline; D004298:Dopamine