3-Arylquinolizidines, potential antidepressant agents.
The synthesis, structure elucidation, and pharmacological evaluation of some 3-arylquinolizidines as semirigid phenethylamines are described. Many of the derivatives posses antidepressant activity. Some anticonvulsant effects are noted.
D000161:Acoustic Stimulation; D000818:Animals; D000928:Antidepressive Agents / Q000138:chemical synthesis* / Q000494:pharmacology / Q000633:toxicity; D004295:Dihydroxyphenylalanine / Q000494:pharmacology; D007928:Lethal Dose 50; D051379:Mice; D008968:Molecular Conformation; D009043:Motor Activity / Q000187:drug effects; D010293:Pargyline / Q000494:pharmacology; D011807:Quinolizines / Q000138:chemical synthesis* / Q000494:pharmacology / Q000633:toxicity; D012640:Seizures / Q000517:prevention & control; D012701:Serotonin / Q000494:pharmacology; D013237:Stereoisomerism
D000928:Antidepressive Agents; D011807:Quinolizines; D012701:Serotonin; D004295:Dihydroxyphenylalanine; D010293:Pargyline