The effect of natural and surgically constructed aortopulmonary shunts on hemodynamic function in tetralogy of Fallot.
A hemodynamic model has been developed for the patient with tetralogy of Fallot. Equations representing the circulatory flow pattern and oxygen balance in this disease were incorporated into a computer program. With the computer model it is possible to simulate the effect of natural and surgically constructed aortopulmonary shunt flow on hemodynamic function in tetralogy of Fallot. Graphic representations of the computer output are presented which show how aortopulmonary shunt flow influences the physiology of exercise and hypoxic episodes. An explanation is advanced for the lack of correlation between resting arterial oxygen saturation and the incidence of hypoxic episodes. The model demonstrates the effect of surgical aortopulmonary shunts in eliminating hypoxic spells.
D001011:Aorta / Q000502:physiology*; D003097:Collateral Circulation; D003201:Computers; D006439:Hemodynamics; D006801:Humans; D000860:Hypoxia / Q000503:physiopathology; D008962:Models, Theoretical; D010100:Oxygen / Q000097:blood; D010101:Oxygen Consumption; D005082:Physical Exertion; D011652:Pulmonary Circulation; D013771:Tetralogy of Fallot / Q000097:blood / Q000503:physiopathology* / Q000601:surgery
D010100:Oxygen