Autoradiographic studies of tn/tn mouse embryos.
High-resolution autoradiographic studies were used to determine whether t12/t12 and tw32/tw32 mouse embryos synthesize the excessive lipid which distinguishes these embryos prior to their death. The studies show that the tn homozygotes synthesize neutral lipid which is stored in intracellular lipid droplets. Cholesterol and phospholipid precursors are not incorporated into these droplets.
D000818:Animals; D003594:Cytoplasmic Granules / Q000378:metabolism; D005804:Genes, Lethal; D005808:Genes, Recessive; D006720:Homozygote; D050356:Lipid Metabolism; D008055:Lipids / Q000096:biosynthesis; D051379:Mice / Q000196:embryology*; D008815:Mice, Inbred Strains; D008928:Mitochondria / Q000378:metabolism; D009154:Mutation
D008055:Lipids