Enzymatic conversion of 5alpha-cholesta-7, 14-dien-3beta-ol to 5alpha-cholesta-8, 14-dien-3beta-ol.
5alpha-Cholesta-7, 14-dien-3beta-ol, previously shown to be efficiently converted to cholesterol upon incubation with rat liver homogenate preparations under aerobic conditions, has been studied as to its possible conversion to 5alpha-cholesta-8, 14-dien-3beta-ol. Efficient conversion was observed upon incubation in the presence of washed mictosomes of rat liver under anaerobic conditions. This observation is of importance in consideration of possible metabolic pathways in the biosythesis of cholesterol.
D000693:Anaerobiosis; D000818:Animals; D002458:Cell Fractionation; D002775:Cholestadienols / Q000378:metabolism*; D002784:Cholesterol / Q000378:metabolism; D005260:Female; D008099:Liver / Q000201:enzymology*; D008862:Microsomes, Liver / Q000201:enzymology; D051381:Rats
D002775:Cholestadienols; D002784:Cholesterol