Efficacy of bunamidine hydrochloride against immature and mature stages of Echinococcus granulosus.
The efficacy of bunamidine hydrochloride (given at dose levels of 25 and 50 mg/kg of body wt) against immature and mature Echinococcus granulosus tapeworms was studied in experimentally infected dogs. The compound had average efficacies of 85.9 to 98.8 percent against the immature stages and was completely efficacious (100 percent clearance) against the mature worms. These data indicate that bunamidine HCl at the given doses can be used as a control measure against hydatid disease in the United States.
D000284:Administration, Oral; D000578:Amidines / Q000008:administration & dosage / Q000627:therapeutic use*; D000818:Animals; D004283:Dog Diseases / Q000188:drug therapy* / Q000469:parasitology; D004285:Dogs; D004443:Echinococcosis / Q000188:drug therapy / Q000469:parasitology / Q000662:veterinary*; D007413:Intestinal Mucosa / Q000469:parasitology; D007421:Intestine, Small / Q000469:parasitology
D000578:Amidines