Mutation induction in Chinese hamster V79 cells by two vinyl chloride metabolites, chloroethylene oxide and 2-chloroacetaldehyde.
Chloroethylene oxide and 2-chloroacetaldehyde, two possibly carcinogenic metabolities of vinyl chloride in mammals, caused a dose-dependent induction of 8-azaguanine- and ouabain-resistant mutants in Chinese hamster V79 cells in vitro. Up to one-hundred-fold higher concentrations of 2-chloroethanol or monochloroacetic acid, a urinary vinyl chloride metabolite in rats and man, were inactive.
D000079:Acetaldehyde / Q000031:analogs & derivatives* / Q000494:pharmacology; D000818:Animals; D001375:Azaguanine / Q000494:pharmacology; D002460:Cell Line; D002471:Cell Transformation, Neoplastic / Q000187:drug effects*; D055598:Chemical Phenomena; D002621:Chemistry; D006224:Cricetinae; D004305:Dose-Response Relationship, Drug; D009154:Mutation / Q000187:drug effects*; D010042:Ouabain / Q000494:pharmacology; D013268:Stimulation, Chemical; D014752:Vinyl Chloride / Q000494:pharmacology*; D014753:Vinyl Compounds / Q000494:pharmacology*
D014753:Vinyl Compounds; D010042:Ouabain; D000079:Acetaldehyde; D001375:Azaguanine; D014752:Vinyl Chloride