Narcotic addiction in the newborn: differences in behavior generated by methadone and heroin.
The nutritive sucking performance of congenitally addicted infants undergoing narcotic withdrawal was used to provide objective measures of adaptive behavior in a series of 50 infants born to mothers addicted either to heroin or methadone. Sucking rates as well as average pressures developed during sucking were significantly reduced for the addicted infants relative to a control group born to normal mothers and a second control group born to toxemic mothers. The subgroup of infants born to methadone-addicted mothers was significantly more depressed with regard to sucking behavior than the infants of heroin-addicted mothers. Furthermore, infants treated with paregoric (an opiate) for symptoms of the narcotic withdrawal syndrome showed significantly less depression of the sucking response than those treated with sedatives such as phenobarbital.
D000222:Adaptation, Physiological; D003975:Diazepam / Q000627:therapeutic use; D005260:Female; D006556:Heroin Dependence / Q000503:physiopathology; D006801:Humans; D007231:Infant, Newborn; D007232:Infant, Newborn, Diseases; D008691:Methadone / Q000009:adverse effects / Q000494:pharmacology*; D009892:Opium / Q000627:therapeutic use; D010634:Phenobarbital / Q000627:therapeutic use; D011247:Pregnancy; D011248:Pregnancy Complications; D013375:Substance Withdrawal Syndrome / Q000188:drug therapy / Q000503:physiopathology; D019966:Substance-Related Disorders / Q000150:complications / Q000503:physiopathology; D013391:Sucking Behavior
D009892:Opium; D003975:Diazepam; D008691:Methadone; D010634:Phenobarbital