[Proceedings: Cortisol-dependent glycogen storage and responses to insulin and glucagon in rat fetal cultured hepatocytes (author's transl)].
It has been shown that in primary cultures of rat fetal hepatocytes cortisol induces the development of glycogen storage ability. Cortisol has also a permissive effect in insulin action on the development of the glycogen synthetic pathway. However the regulation of glycogenolytic pathway by glucagon, which is present before any significant amount of glycogen storage, is not cortisol dependent.
D000818:Animals; D002478:Cells, Cultured; D005333:Fetus; D005934:Glucagon / Q000494:pharmacology; D006854:Hydrocortisone / Q000494:pharmacology*; D066298:In Vitro Techniques; D008099:Liver / Q000187:drug effects; D008112:Liver Glycogen / Q000096:biosynthesis / Q000378:metabolism*; D051381:Rats
D008112:Liver Glycogen; D005934:Glucagon; D006854:Hydrocortisone
Rôle du cortisol sur le développement de la fonction glycogénique du rat et sa régulation dans l'hépatocyte foetal en culture