The effect of serum from ALS patients on organotypic nerve and muscle tissue cultures.
Serum from 11 ALS patients was assayed for cytotoxic activity using several different organ culture models. No specific neurotoxic activity was found. Slight myelinotoxic activity was present in 2 sera. (A total of 415 cultures were examined).
D000690:Amyotrophic Lateral Sclerosis / Q000097:blood*; D000818:Animals; D000870:Anterior Horn Cells / Q000473:pathology*; D002470:Cell Survival; D005727:Ganglia, Spinal / Q000473:pathology; D006801:Humans; D009046:Motor Neurons / Q000473:pathology*; D009413:Nerve Fibers, Myelinated / Q000473:pathology; D009457:Neuroglia / Q000473:pathology; D009474:Neurons / Q000473:pathology*; D009924:Organ Culture Techniques; D013116:Spinal Cord / Q000473:pathology