Measurement of cell production rates in human gastro-intestinal cancer--a guide to treatment?
Cell production rates were measured in 19 cases of rectal carcinoma and in 11 cases of gastric carcinoma using a stathmokinetic technique. These measurements were compared with results from normal rectal and gastric mucosa. It was found that most of the cases of rectal cancer were proliferating more slowly than morphologically normal rectal mucosa. This was true for the majority of gastric cancers, but a small proportion appeared to be proliferating more rapidly. These results are discussed with their relevance to appropriate therapy.
D001706:Biopsy; D005753:Gastric Mucosa / Q000473:pathology*; D006801:Humans; D007410:Intestinal Diseases / Q000473:pathology; D007413:Intestinal Mucosa / Q000473:pathology*; D008113:Liver Neoplasms / Q000473:pathology; D008679:Metaplasia / Q000473:pathology; D008938:Mitosis / Q000187:drug effects; D008940:Mitotic Index; D009362:Neoplasm Metastasis; D012004:Rectal Neoplasms / Q000473:pathology*; D013274:Stomach Neoplasms / Q000473:pathology*; D014750:Vincristine / Q000494:pharmacology
D014750:Vincristine