Effects of intensive application of retinoic acid on human skin.
The daily application of 0-3% retinoic acid to the back produced an acute irritant dermatitis which resolved to a near-normal clinical appearance within 40 days despite continued daily exposure. Hardened skin was markedly altered physiologically. The responses to DMSO, histamine and the histamine liberator, compound 48/80, were sharply enhanced. This reflected enhanced permeability resulting from reduction of the horny layer to less than one-half its normal thickness. Phototoxic and irritant substances produced exaggerated reactions owing to greater penetration. A paradoxical decrease in delayed sinsitivity to streptodornase-streptokinase was attributed to enhanced clearance of the antigen.
D000328:Adult; D003877:Dermatitis, Contact / Q000209:etiology* / Q000276:immunology / Q000473:pathology; D004121:Dimethyl Sulfoxide / Q000378:metabolism; D006632:Histamine / Q000494:pharmacology; D006801:Humans; D006968:Hypersensitivity, Delayed; D010539:Permeability; D012867:Skin / Q000378:metabolism / Q000473:pathology / Q000503:physiopathology; D014212:Tretinoin / Q000009:adverse effects; D014801:Vitamin A / Q000031:analogs & derivatives*; D003189:p-Methoxy-N-methylphenethylamine / Q000494:pharmacology
D014801:Vitamin A; D003189:p-Methoxy-N-methylphenethylamine; D014212:Tretinoin; D006632:Histamine; D004121:Dimethyl Sulfoxide