L-1210 and human acute leukemia kinetics as related to therapy.
Comparative considerations are made between human acute leukemia (AL) and mouse transplantable L-1210 leukemia. The main kinetic parameters, such as the growth fraction (GF), growth rate, and cell cycle times, of both human and mouse diseases, are compared. The striking differences in cell kinetics and in response to treatment may be viewed as depending on different leukemogenesis mechanisms. Therefore, some improvement in human AL chemotherapy is considered possible both by researching a more rational employment of cytostatic drugs, and studying other animal models quite similar to the human disease, such as AKR leukemia.
D000208:Acute Disease; D000818:Animals; D000970:Antineoplastic Agents / Q000627:therapeutic use; D002455:Cell Division; D004195:Disease Models, Animal; D007938:Leukemia / Q000473:pathology*; D007939:Leukemia L1210 / Q000188:drug therapy / Q000473:pathology*; D051379:Mice
D000970:Antineoplastic Agents