The mechanism of action of methotrexate. III. Requirement of free intracellular methotrexate for maximal suppression of (14C)formate incorporation into nucleic acids and protein.
D000818:Animals; D002250:Carbon Radioisotopes; D004247:DNA / Q000096:biosynthesis*; D003864:Depression, Chemical; D005347:Fibroblasts / Q000378:metabolism; D005561:Formates / Q000378:metabolism*; D007739:L Cells / Q000378:metabolism; D008727:Methotrexate / Q000494:pharmacology*; D051379:Mice; D014176:Protein Biosynthesis; D012313:RNA / Q000096:biosynthesis*; D013997:Time Factors
D002250:Carbon Radioisotopes; D005561:Formates; D012313:RNA; D004247:DNA; D008727:Methotrexate