Gonadectomy and the development of age-dependent polydipsia and the intake of NaCl solutions in the SWR/J mouse.
Gonadectomies were performed at 25 days of life in SWR/J mice, a strain known to develop age-dependent nephrogenic diabetes insipidus with females drinking far more than males. Effect of gonadectomy was different for each of the 3 nonreproductive behaviors studied. (1) Ovariectomy reduced the age-dependent polydipsia seen in females, but castration was without effect in males. (2) Castration of males resulted in a lower intake of an isotonic NaCl solution, making the castrated males similar to the sham-operated and ovariectomized females which did not differ. (3) For the short-term activity measurement sham-operated males did not differ from sham-operated females and castrated males did not differ from ovariectomized females. In each sex, gonadectomy reduced activity.
D000818:Animals; D001835:Body Weight; D002369:Castration; D003919:Diabetes Insipidus / Q000503:physiopathology; D004326:Drinking; D004435:Eating; D004967:Estrogens / Q000502:physiology*; D005260:Female; D005947:Glucose; D007674:Kidney Diseases / Q000503:physiopathology; D008297:Male; D051379:Mice; D009043:Motor Activity / Q000502:physiology; D009929:Organ Size; D012737:Sex Factors; D012965:Sodium Chloride; D013739:Testosterone / Q000502:physiology*
D004967:Estrogens; D013739:Testosterone; D012965:Sodium Chloride; D005947:Glucose