Prebiotic peptide-formation in the solid state. I. Reactions of benzoate ion and glycine with adenosine 5'-phosphorimidazolide.
The reactions of benzoate ion and of glycine with adenosine 5-phosphorimidazolide have been investigated. Benzoate reacts first to give the anhydride, benzoyl-adenylate, which, in the presence of excess imidazole, reacts further to give the 2'- and 3'-esters of adenosine 5'-phosphate. Glycine also first attacks the imidazolide to give an anhydride, but this compound may react further either to give 2- and 3'-esters or to form peptides, depending on the reaction conditions.
D000227:Adenine Nucleotides; D001565:Benzoates; D005075:Biological Evolution; D055598:Chemical Phenomena; D002621:Chemistry; D005998:Glycine; D007093:Imidazoles; D010455:Peptides / Q000138:chemical synthesis*
D000227:Adenine Nucleotides; D001565:Benzoates; D007093:Imidazoles; D010455:Peptides; D005998:Glycine