Treatment of basophilic leukemia in a dog.
Basophilic leukemia in a 6-year-old dog was characterized by marked splenomegaly, anemia, and leukocytosis in which 89% of the circulating leukocytes were basophilis. After an attempt at busulfan therapy, the dog was treated with hydroxyurea and was maintained on this drug for 2 months. After withdrawl of hydroxyurea, the dog remained in remission and was still in remission at the time of writing (8 months later).
D000818:Animals; D001491:Basophils; D001853:Bone Marrow / Q000473:pathology; D001854:Bone Marrow Cells; D002066:Busulfan / Q000627:therapeutic use; D004283:Dog Diseases / Q000097:blood / Q000188:drug therapy*; D004285:Dogs; D004906:Erythrocyte Count; D006918:Hydroxyurea / Q000627:therapeutic use; D007527:Isoenzymes; D007770:L-Lactate Dehydrogenase / Q000097:blood; D007938:Leukemia / Q000097:blood / Q000188:drug therapy / Q000662:veterinary*; D007958:Leukocyte Count; D012075:Remission, Spontaneous; D013163:Splenomegaly / Q000662:veterinary; D013922:Thrombocytosis / Q000097:blood / Q000662:veterinary
D007527:Isoenzymes; D007770:L-Lactate Dehydrogenase; D002066:Busulfan; D006918:Hydroxyurea