Age-related variations in glycosylation of hydroxylysine in human and rat skin collagens.
The extent of glycosylation of hydroxylysine in human skin collagen rapidly decreased during maturation and then gradually increased in proportion to the age. This decrease of glycosylation observed during maturation was also confirmed in whole, soluble and insoluble collagens from rat skin. These findings may contribute to the investigations on the functional role of glycosylation and also on the mechanism of maturational as well as senile processes.
D000293:Adolescent; D000328:Adult; D000368:Aged; D000375:Aging; D000818:Animals; D002648:Child; D003094:Collagen / Q000378:metabolism*; D005697:Galactosides / Q000378:metabolism; D005960:Glucosides / Q000378:metabolism; D006027:Glycosides / Q000378:metabolism*; D006801:Humans; D006901:Hydroxylysine / Q000378:metabolism*; D008875:Middle Aged; D051381:Rats; D012867:Skin / Q000254:growth & development / Q000378:metabolism*; D013045:Species Specificity
D005697:Galactosides; D005960:Glucosides; D006027:Glycosides; D006901:Hydroxylysine; D003094:Collagen