Conditioned learning in young rats born of drug-addicted parents and raised on addictive drugs.
Ratlings born of six drug-addicted and a control group of parent rats were raised under the influence of the same drugs administered in drinking water. They were trained in a conditioned avoidance paradigm (CAR) from the 7th week when the drugs were withdrawn except in two subgroups of flurazepam and morphine. The growth rate was not appreciably impaired except for temporary slowness in morphine and alcohol-raised rats; it was faster in phenobarbitone and meprobamate-raised rats. The CAR-acquisition rates of the treatment groups were quite close and parallel to that of the controls except for the morphine, meprobamate, medazepam and the two drug-trained subgroups; whereas, the rats raised on low-dose morphine showed a faster than control acquisition rate. No evidence of state-dependent learning was obtained from this study.
D000818:Animals; D000831:Animals, Newborn; D001362:Avoidance Learning / Q000187:drug effects* / Q000502:physiology; D001724:Birth Weight / Q000187:drug effects; D001835:Body Weight / Q000187:drug effects; D003213:Conditioning, Psychological / Q000187:drug effects* / Q000502:physiology; D000431:Ethanol / Q000494:pharmacology; D005260:Female; D005479:Flurazepam / Q000494:pharmacology; D006801:Humans; D008297:Male; D008472:Medazepam / Q000494:pharmacology; D008620:Meprobamate / Q000494:pharmacology; D009021:Morphine Dependence / Q000503:physiopathology; D010634:Phenobarbital / Q000494:pharmacology; D011247:Pregnancy; D051381:Rats; D011919:Rats, Inbred Strains; D011930:Reaction Time / Q000187:drug effects; D019966:Substance-Related Disorders / Q000503:physiopathology*
D000431:Ethanol; D008620:Meprobamate; D005479:Flurazepam; D008472:Medazepam; D010634:Phenobarbital