[Proceedings: Prolactin adenoma revealed by gemellary? pregnancy after clomiphen therapy. Hypophysectomy during 5 th month of pregnancy (author's transl)].
A 25 year old woman had galactorrhea and secondary amenorrhea since her first pregnancy at 20 years. After several treatments with Clomiphene, menses reappeared for 2 months and she became pregnant. At admission, she was in her 4th pregnancy month and had headaches and bitemporal hemianopsia. Hypophysectomy was performed during 5th pregnancy month. Prolactin adenoma with hemorragic lesions was found. Parturition of normal twins occurred 8th month. Partial hypophyseal recovery took place for the following 2 years, but hyperprolactinemia reappeared too.
D000236:Adenoma / Q000150:complications / Q000188:drug therapy / Q000378:metabolism; D000328:Adult; D000568:Amenorrhea / Q000209:etiology; D002996:Clomiphene / Q000627:therapeutic use*; D005260:Female; D005687:Galactorrhea / Q000209:etiology; D006801:Humans; D007016:Hypophysectomy; D010911:Pituitary Neoplasms / Q000150:complications / Q000188:drug therapy / Q000378:metabolism*; D011247:Pregnancy; D011272:Pregnancy, Multiple; D011388:Prolactin / Q000378:metabolism*; D014427:Twins
D002996:Clomiphene; D011388:Prolactin
Adénome à prolactine révélé par une grossesse gemellaire après traitement par clomiphène. Hypophysectomie au 5 mois de la grossesse