Cyclic hematopoiesis in a colony of dogs.
A laboratory-maintained colony of dogs heterozygous for cyclic hematopoiesis (ch) has been established. The colony consists of Collies and Collie-Beagle mixed dogs. Matings between dogs heterozygous for ch resulted in 110 pups, 28 of which were homozygous for ch. Each of the 28 homozygous ch pups (15 females and 13 males) was gray and white. Ninetten of them survived the preweaning period and were found to have cyclic fluctuations of neutrophils, platelets, and reticulocytes.
D000818:Animals; D000831:Animals, Newborn; D001772:Blood Cell Count; D001792:Blood Platelets; D003433:Crosses, Genetic; D003967:Diarrhea / Q000662:veterinary; D004283:Dog Diseases / Q000097:blood / Q000235:genetics*; D004285:Dogs; D004906:Erythrocyte Count; D005260:Female; D006400:Hematocrit; D006402:Hematologic Diseases / Q000235:genetics / Q000662:veterinary*; D006410:Hematopoiesis; D006579:Heterozygote; D006720:Homozygote; D007958:Leukocyte Count; D008297:Male; D009503:Neutropenia / Q000662:veterinary; D009504:Neutrophils / Q000166:cytology; D011014:Pneumonia / Q000662:veterinary; D012156:Reticulocytes / Q000166:cytology