Effect of oxethazaine HCl on control of food and water intake in the rat.
Oral administration of the local anesthetic oxethazaine HCl was used to modify eating and drinking patterns in the rat. The addition of the oxethazaine HCl to the diet (0.5 gm/100 gm diet) markedly reduced food intake. Similarly, administration of the drug by gastric intubation (gavage) also reduced food intake. This reduction was of short duration. The inhibition of water intake associated with administration of the drug was shown to be a secondary effect of reduced food intake, rather than a direct action of the drug. The data indicate that local anesthesia of the gastrointestinal tract results in an inhibition of food intake.
D000284:Administration, Oral; D000818:Animals; D004064:Digestive System / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D004327:Drinking Behavior / Q000187:drug effects*; D004983:Ethanolamines / Q000008:administration & dosage / Q000494:pharmacology*; D005247:Feeding Behavior / Q000187:drug effects*; D008297:Male; D051381:Rats; D013395:Sucrose; D013997:Time Factors
D004983:Ethanolamines; D013395:Sucrose