[Treatment of anovulatory sterility using clomiphen].
74 patients with anovulatory sterility were treated with clomiphene for 5 consecutive days starting on the 5th day of the cycle. The dosage was in the first course of treatment 50 mg daily. The patients, who did not conceive after this dosage, were treated with higher doses of clomiphene (100 and 150 mg daily). In 66% of the cases ovulation and in 32% (49% of induced ovulation) pregnancies were achieved. In the first treatment cycle with 50 mg/day for 5 days ovulation was obtained in 27 out of 74 patients. 14 patients, who failed to ovulate after this dosage, did ovulate after they were treated with 100 mg/day in the second treatment cycle. In 8 cases was a third treatment cycle with 150 mg/day needed to chieve a positive result. The conception rate per ovulatory cycle decreased with increasing dosage. The ovulation as judged on the basis of the temperature curve and pregnandiol excretion occured between the 4th and 25th day of treatment, whereas ovulation which were followed by pregnancy occured only between the 11th and 25th day.
D000293:Adolescent; D000328:Adult; D001831:Body Temperature; D002996:Clomiphene / Q000008:administration & dosage / Q000627:therapeutic use*; D004305:Dose-Response Relationship, Drug; D004717:Endometrium / Q000473:pathology; D005260:Female; D006801:Humans; D007247:Infertility, Female / Q000188:drug therapy*; D010060:Ovulation / Q000187:drug effects; D011247:Pregnancy / Q000187:drug effects; D011276:Pregnanediol
D002996:Clomiphene; D011276:Pregnanediol
Behandlung der anovulatorischen Sterilität mit Clomiphen