Morphological responses of cerebral tissues to temporary ischemia.
The ultrastructural responses of cerebral tissue following temporary periods (1/2, 1,2,3, or 4 hour) of right, middle cerebral artery, (MCA) occlusion were studied acutely after a 3 day or 7 day interval following the removal of the MCA clip. Cortical and basal ganglia tissues for each ischemic duration were compared at 3 post-occlusive periods (acute, 3 days, 7 days). With the short periods of ischemic insult (1/2, 1, 2, 3, and 4 hour), the temporal and insular cortex contained no greater changes in the 7 day group than in the 3 day group. The basal ganglia were more susceptible to MCA occlusion as indicated by more marked cytological changes and/or necrosis in all intervals of ischemia.
D000208:Acute Disease; D000818:Animals; D001479:Basal Ganglia / Q000648:ultrastructure*; D002421:Caudate Nucleus / Q000098:blood supply / Q000648:ultrastructure; D002536:Cerebral Arteries; D002540:Cerebral Cortex / Q000648:ultrastructure*; D005917:Globus Pallidus / Q000098:blood supply / Q000648:ultrastructure; D002546:Ischemic Attack, Transient / Q000473:pathology*; D008854:Microscopy, Electron; D010296:Parietal Lobe / Q000098:blood supply / Q000648:ultrastructure; D011699:Putamen / Q000098:blood supply / Q000648:ultrastructure; D012453:Saimiri; D013702:Temporal Lobe / Q000098:blood supply / Q000648:ultrastructure