Adducted thumb syndromes.
The adducted thumbs syndrome is characterized by cleft palate, microcephaly, and dysmyelination. A fifth case of this syndrome is presented. Several other syndromes which may present with adducted thumbs are reviewed and re-assessed. The original contributions consist of discussions of (1) the possible pathogenesis of adducted thumbs in the congenital clasped thumb syndrome, and (3) the significance of adducted thumbs as a possible marker in sex-linked hydrocephalus.
D000015:Abnormalities, Multiple / Q000235:genetics*; D002972:Cleft Palate; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D008607:Intellectual Disability; D008831:Microcephaly; D009186:Myelin Sheath; D013933:Thumb / Q000002:abnormalities*