Modification of some hematologic and biochemical indices in mice consecutive mecadox administration.
Mecadox addition to the diet of laboratory mice in doses of 25 mg/kg/day for 30 days resulted in some hematologic and biochemical modifications: 1. Red cell count declined moderately, leucocyte and neutrophile count was higher and reached their normal values 15 days following treatment. 2. Modifications of liver transaminases expressed by a diminution of GOT and GPT activities were observed together with a reduction of free nitrogen. Values returned to normal within 15 days after treatment. 3. Mecadox stimulated weight gain in treated animals during the first 15 days of treatment. No significant differences were observed in weight gain between the two groups during the period which followed treatment.
D000410:Alanine Transaminase / Q000097:blood; D000596:Amino Acids / Q000097:blood; D000818:Animals; D001219:Aspartate Aminotransferases / Q000097:blood; D001769:Blood / Q000187:drug effects*; D001798:Blood Proteins / Q000032:analysis; D004906:Erythrocyte Count; D004912:Erythrocytes / Q000187:drug effects; D006098:Granulocytes / Q000187:drug effects; D007962:Leukocytes / Q000187:drug effects; D051379:Mice; D011810:Quinoxalines / Q000008:administration & dosage*
D000596:Amino Acids; D001798:Blood Proteins; D011810:Quinoxalines; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase