Availability of phendimetrazine from sustained and non-sustained action formulations.
Two tablet formulations of d-phendimetrazine bitartrate, Obex (35 mg non-sustained action) and Obex-LA (105 my sustained action), were compared in terms of biological availability in 9 volunteers on the basis of serum level findings. The ratio of the areas under the absorption and elimination curves was 1:2,2 (Obex:Oves-LA), indicating that the biological availability of phendimetrazine from Obex-LA was plus or minus 70% of that from Obex. The elimination half-life of phendimetrazine was found to be 9,1 hours. An evaluation of appetite suppression revealed that the two formulations were equally effective at breakfast and at dinner, with Obex-LA significantly superior to Obex at lunch.
D000328:Adult; D001066:Appetite / Q000187:drug effects; D001682:Biological Availability; D001702:Biopharmaceutics; D001835:Body Weight / Q000187:drug effects; D002849:Chromatography, Gas; D003692:Delayed-Action Preparations; D003864:Depression, Chemical; D005260:Female; D006207:Half-Life; D006801:Humans; D008297:Male; D009025:Morpholines / Q000008:administration & dosage* / Q000009:adverse effects / Q000097:blood / Q000494:pharmacology; D013607:Tablets
D003692:Delayed-Action Preparations; D009025:Morpholines; D013607:Tablets