Evaluation of creatinine phosphokinase in screening patients for malignant hyperpyrexia.
Evidence is presented that serum creatinine phosphokinase (CPK) activity is of no direct value in screening patients for susceptibility to malignant hyperpyrexia and does not correlate with halothane-induced muscle contracture or the presence of myopathy. Widely differing CPK values were found at different times in the same people. In most "malignant hyperpyrexia" families the susceptible patients had either normal or inconsistently raised CPK values.
D003402:Creatine Kinase / Q000097:blood*; D005069:Evaluation Studies as Topic; D006221:Halothane / Q000009:adverse effects; D006801:Humans; D066298:In Vitro Techniques; D008305:Malignant Hyperthermia / Q000175:diagnosis*; D009119:Muscle Contraction / Q000187:drug effects; D009132:Muscles / Q000473:pathology
D003402:Creatine Kinase; D006221:Halothane