Inhibitory action of antidiuretic hormone on canine pancreatic exocrine flow.
A direct relationship was observed between the percentage inhibition of secretin-stimulated pancreatic exocrine flow and the dose of antidiuretic hormone administered with the minimal effective concentration being 0.75 m units/kg or 0.012 m units/ml. An alteration in the molecular configuration of the antidiuretic hormone modified its ability to inhibit secretin-stimulated pancreatic exocrine secretion.
D000758:Anesthesia / Q000009:adverse effects; D000818:Animals; D004285:Dogs; D004305:Dose-Response Relationship, Drug; D010179:Pancreas / Q000187:drug effects*; D010424:Pentobarbital / Q000009:adverse effects; D012633:Secretin / Q000037:antagonists & inhibitors*; D013329:Structure-Activity Relationship; D014667:Vasopressins / Q000494:pharmacology*
D014667:Vasopressins; D012633:Secretin; D010424:Pentobarbital