Structural aspects of the effect of ethyl benzoates on caffeine contracture.
The effect of ethyl benzoate, ethyl o- and p-fluorobenzoate and ethyl o- and p-toluate on the caffeine-induced contracture of frog sartorius muscle was investigated. All drugs with the exception of ethyl o-toluate depressed caffeine-induced contractures. It is proposed that the methyl group in ethyl o-toluate sterically blocks the ester carbonyl group from exerting its inhibitory action. It is further proposed that ethyl o-aminobenzoate exerts its potentiating effect through the lone pair of electrons on the nitrogen atom.
D000818:Animals; D001001:Anura; D001565:Benzoates / Q000494:pharmacology*; D002110:Caffeine / Q000037:antagonists & inhibitors* / Q000494:pharmacology; D066298:In Vitro Techniques; D009119:Muscle Contraction / Q000187:drug effects*; D013329:Structure-Activity Relationship; D013997:Time Factors
D001565:Benzoates; D002110:Caffeine