Nitrosobenzene-induced ferrihemoglobin formation in Japanese quail erythrocytes. The significance of ferrihemoglobin reduction.
Quantitative aspects of nitrosobenzene-induced ferrihemoglobin formation were studied in quail erythrocytes in comparison to goat red cells. Many similarities exist with the mechanism in mammalian red cells such as a NADPH-dependent enzymatic recycling of phenylhydroxylamine from nitrosobenzene. Also the mechanism of ferrihemoglobin reduction is similar in both species, it is a NADH-dependent process. However, the reducing activity of quail red cells exceeds by far the activity of the majority of mammalian erythrocytes.
D000818:Animals; D003370:Coturnix / Q000097:blood*; D004912:Erythrocytes / Q000378:metabolism*; D006041:Goats / Q000097:blood; D006454:Hemoglobins / Q000378:metabolism; D066298:In Vitro Techniques; D008706:Methemoglobin / Q000096:biosynthesis*; D009573:Nitrites / Q000494:pharmacology; D009603:Nitroso Compounds / Q000494:pharmacology*; D010084:Oxidation-Reduction; D011784:Quail / Q000097:blood*; D013997:Time Factors
D006454:Hemoglobins; D009573:Nitrites; D009603:Nitroso Compounds; D008706:Methemoglobin