Active otosclerotic foci in the stapes. An electron microscopic study.
A total of 12 undecalcified and decalcified otosclerotic stapes containing active spongiotic lesions were examined using an electron microscope. Evidence of osteolytic osteolysis was seen in all specimens, but osteoclasts were observed in only four. The advancing  front in the spongiotic lesion was 'moth-eaten' due to the demineralization of canaliculi and lacunae. The demineralizing process appeared to be initiated by degranulation of lysosomes by the degenerating osteocytes. As bone resorption continued, poorly mineralized new bone was laid down by osteoblasts which showed mitochondrial swelling. The possible implication of this mitochondrial swelling is discussed in relation to the pathology of the otosclerosis.
D004429:Ear Ossicles / Q000648:ultrastructure*; D006801:Humans; D008264:Macrophages / Q000648:ultrastructure; D008903:Minerals / Q000378:metabolism; D008933:Mitochondrial Swelling; D010006:Osteoblasts / Q000648:ultrastructure; D010010:Osteoclasts / Q000648:ultrastructure; D010011:Osteocytes / Q000648:ultrastructure; D010014:Osteolysis; D010040:Otosclerosis / Q000378:metabolism / Q000473:pathology*; D013199:Stapes / Q000378:metabolism / Q000648:ultrastructure*
D008903:Minerals