Pulmonary talc embolization.
A young woman with a history of drug abuse rapidly developed cor pulmonale, restrictive pulmonary defect, low diffusion capacity, and a suggestion of left ventricular dysfunction. She died from complications after a lung biopsy. Microscopic examination showed talc granulomas and arteritis. Some form of closed biopsy is probably safer, and trial of corticosteroid therapy seems warranted for this diagnosis. Talc ia a dangerous ingredient for any oral preparation that is likely to be used parenterally.
D000328:Adult; D005260:Female; D006556:Heroin Dependence / Q000150:complications*; D006801:Humans; D007275:Injections, Intravenous / Q000009:adverse effects*; D008168:Lung / Q000098:blood supply / Q000473:pathology; D011650:Pulmonary Alveoli / Q000473:pathology; D011655:Pulmonary Embolism / Q000209:etiology* / Q000473:pathology; D013627:Talc / Q000009:adverse effects*
D013627:Talc