Effect of alcohol on total urinary hydroxyproline excretion.
Urinary hydroxyproline excretion was measured in 33 patients regularly drinking over 80 gm. alcohol daily. Those with changes of cirrhosis on liver biopsy excreted significantly more hydroxyproline than those with normal appearances, fatty change or hepatofibrosis. In 16 patients, the excretion was measured both when they were drinking and when abstaining from alcohol, in the form of several beverages. The rate of excretion was significantly higher after alcohol has been withdrawn. This result raises the possibility that alcoholic beverages may inhibit collagen degradation. If substantiated, it further suggests that the effect of alcohol on collagen metabolism may be of importance in the pathogenesis of alcoholic cirrhosis.
D000437:Alcoholism / Q000150:complications / Q000473:pathology / Q000652:urine*; D001706:Biopsy; D004032:Diet; D006801:Humans; D006909:Hydroxyproline / Q000652:urine*; D008099:Liver / Q000473:pathology; D008103:Liver Cirrhosis / Q000150:complications / Q000473:pathology / Q000652:urine
D006909:Hydroxyproline