The absolute configuration of the enantiomers of glutethimide and aminoglutethimide.
Aminoglutethimide (Elipten¿ CIBA) was resolved into the optical antipodes I and II. The endocrinological properties and the absolute configuration of both enantiomers I and II were determined. Most of the steroidal synthesis inhibition was found in the (+) enantiomer II. On the basis of circular dichroism, the R-configuration was assigned to the (+) enantiomer II.
D000311:Adrenal Glands / Q000187:drug effects; D000616:Aminoglutethimide / Q000494:pharmacology; D000818:Animals; D002942:Circular Dichroism; D005260:Female; D005984:Glutethimide; D008968:Molecular Conformation; D010053:Ovary / Q000187:drug effects; D051381:Rats; D013237:Stereoisomerism
D000616:Aminoglutethimide; D005984:Glutethimide