[Bromhexine residues in calves, pigs, and in the milk of cows].
After several oral applications of N-cyclohexyl-N-methyl-(2-amino-3,5-dibromobenzyl)-aminehydrochloride (bromhexine, Bisolvon-R) to various calves and pigs the residue behaviour was examined. In animals slaughtered immediately after the final application significant amounts of Bisolvon were found. The substance showed a greater affinity to liver and fat tissue whilst, in general, in the muscle tissue, the lungs and kidneys only very small amounts were traceable. In the liver and lungs 3 different metabolites appeared in small quantities. They were partly in conjugated and partly in free form. Within 2 days the amounts greatly decreased and after 7 days at the latest, no residues were traceable; only in the fat of both animal species and in the kidneys of the calves were small quantities of Bisolvon still to be found. Excretion by the milk following oral and parenteral application was also studied. Only traces of Bisolvon were found, which rapidly decreased. Results of the studies show that, neither at a later date of slaughtering nor immediately after the final application, the residues in the animal tissues and in the milk examined present a danger to the health of the human consumer.
D000273:Adipose Tissue / Q000032:analysis; D000284:Administration, Oral; D000818:Animals; D001964:Bromhexine / Q000031:analogs & derivatives / Q000032:analysis*; D002417:Cattle / Q000378:metabolism*; D005260:Female; D007273:Injections, Intramuscular; D007668:Kidney / Q000032:analysis; D008099:Liver / Q000032:analysis; D008168:Lung / Q000032:analysis; D008892:Milk / Q000032:analysis*; D009132:Muscles / Q000032:analysis; D009928:Organ Specificity; D013552:Swine / Q000378:metabolism*; D013997:Time Factors
D001964:Bromhexine
Analytische Untersuchungen über das Auftreten von Bromhexin-RUckständen, durchgeführt an KAlbern, Schweinen und in der Milch von KUhen