Toxicity studies of coronary arteriographic media in dogs.
Sequential injections of different contrast material in the canine coronary artery were performed while ventricular pressure and EKG were recorded. Larger volumes of contrast material caused more fibrillation and more drop in pressure. Preliminary myocardial infarction increased pressure effects. Diatrizoate methylglucamine (Renografin-76) caused more fibrillation and lowering of ventricular pressure than iothalamate or metrizoate Coronar. Calcium lessened the ventricular pressure depression from iothalamate.
D000792:Angiography; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D002118:Calcium / Q000494:pharmacology; D003287:Contrast Media / Q000633:toxicity*; D017023:Coronary Angiography; D003331:Coronary Vessels / Q000187:drug effects; D003974:Diatrizoate Meglumine / Q000633:toxicity; D004285:Dogs; D004562:Electrocardiography; D006321:Heart / Q000187:drug effects*; D006352:Heart Ventricles / Q000187:drug effects; D007022:Hypotension / Q000139:chemically induced; D007483:Iothalamic Acid / Q000633:toxicity; D008794:Metrizoic Acid / Q000633:toxicity; D009203:Myocardial Infarction / Q000503:physiopathology; D014693:Ventricular Fibrillation / Q000139:chemically induced
D003287:Contrast Media; D007483:Iothalamic Acid; D003974:Diatrizoate Meglumine; D008794:Metrizoic Acid; D002118:Calcium