Central catecholamine receptor blocking actions of BE-2254 ('heat'): comparison with chlorpromazine and haloperidol.
BE-2254, 2-[beta-(4-hydroxyphenyl)-ethylaminomethyl]-tetralone, (ED50 = 3.4 mg/kg i.p.) was about equal to chlorpromazine (ED50 = 4.4) as an antagonist of central noradrenergic receptor stimulation produced by clonidine (enhancement of the flexor reflex in spinalized rats). Haloperidol and phentolamine had essentially no effect at 9 mg/kg i.p...
D000661:Amphetamine / Q000037:antagonists & inhibitors; D000818:Animals; D001058:Apomorphine / Q000037:antagonists & inhibitors; D002395:Catecholamines / Q000378:metabolism*; D002746:Chlorpromazine / Q000494:pharmacology*; D003000:Clonidine / Q000037:antagonists & inhibitors; D005021:Ethylamines / Q000494:pharmacology; D005260:Female; D006220:Haloperidol / Q000494:pharmacology*; D006801:Humans; D051379:Mice; D008815:Mice, Inbred Strains; D009043:Motor Activity / Q000187:drug effects; D009281:Naphthalenes / Q000494:pharmacology*; D010627:Phenethylamines / Q000494:pharmacology*; D011955:Receptors, Drug; D012018:Reflex / Q000187:drug effects; D013239:Stereotyped Behavior / Q000187:drug effects; D044024:Tetralones
D002395:Catecholamines; D005021:Ethylamines; D009281:Naphthalenes; D010627:Phenethylamines; D011955:Receptors, Drug; D044024:Tetralones; C010652:BE 2254; D000661:Amphetamine; D006220:Haloperidol; D003000:Clonidine; D001058:Apomorphine; D002746:Chlorpromazine