Antenatal sex determination in blood from pregnant women.
Reported results concern Y-chromatin of lymphocytes and granulocytes in the peripheral blood of pregnant women. In  women who later delivered male children, a mean of 3.75% Y-chromatin was found in lymphocytes. Even after investigation of paternal Y-chromatin, the rate of false diagnoses (14%) in prenatal sex diagnosis could be reduced only moderately. In early pregnancy lymphoid cells with a Y-chromatin could be first traced only in the 8th week; granulocytes showing a Y-chromatin did not appear until the 9th week.
D002465:Cell Movement; D003951:Diagnostic Errors; D005260:Female; D005865:Gestational Age; D006098:Granulocytes / Q000166:cytology; D006801:Humans; D007962:Leukocytes / Q000166:cytology*; D008214:Lymphocytes / Q000166:cytology; D008297:Male; D008431:Maternal-Fetal Exchange; D011247:Pregnancy; D011296:Prenatal Diagnosis; D012728:Sex Chromatin / Q000032:analysis; D012730:Sex Chromosomes / Q000032:analysis; D012732:Sex Determination Analysis