[Study of the mechanism of action of the new antidepressant pyrazidol].
The biochemical mechanism of action produced by a new antidepressant pyrazidol (1,10-trimethylene-8-methyl-1, 2, 3, 4-tetrahydropyrazino[1,2-a] indole hydrochloride) includes the inhibitory influence on the neuronal uptake of norepinephrine and a reversible comparatively short-lived inhibitory effect on the MAO activity.
D000818:Animals; D000928:Antidepressive Agents / Q000494:pharmacology*; D001921:Brain / Q000187:drug effects / Q000378:metabolism; D003864:Depression, Chemical; D003891:Desipramine / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D006247:Harmine / Q000494:pharmacology; D006321:Heart / Q000187:drug effects; D007099:Imipramine / Q000494:pharmacology; D066298:In Vitro Techniques; D007211:Indoles / Q000494:pharmacology*; D007490:Iproniazid / Q000494:pharmacology; D051379:Mice; D008930:Mitochondria, Liver / Q000187:drug effects / Q000378:metabolism; D008996:Monoamine Oxidase Inhibitors / Q000494:pharmacology; D009206:Myocardium / Q000378:metabolism; D009474:Neurons / Q000187:drug effects / Q000378:metabolism; D009638:Norepinephrine / Q000378:metabolism; D011719:Pyrazines / Q000494:pharmacology*; D051381:Rats; D013997:Time Factors
D000928:Antidepressive Agents; D007211:Indoles; D008996:Monoamine Oxidase Inhibitors; D011719:Pyrazines; D006247:Harmine; D007490:Iproniazid; D007099:Imipramine; D003891:Desipramine; D009638:Norepinephrine
Issledovanie mekhanizma deĭstviia novogo antidepressanta pirazidola