Cannulation of the proximal aorta during long-term membrane lung perfusion.
Prolonged extracorporeal oxygenator support for acute respiratory failure is a clinical reality. Recent experience with 4 patients has demonstrated an advantage in delivery of saturated blood to the root of the aorta during venoarterial (VA) bypass. We have been able to perfuse the heart and bilateral cerebral hemispheres by advancing the tip of a large perfusion cannula to the aortic root from the common femoral artery. When the catheter did not pass beyond the transverse aortic arch, there was marked asymmetry of oxygenator perfusion, as determined by differential oxygen tension in right and left radial artery blood and by xenon-133 scans following isotope injection into the arterial return line. Long-term VA bypass lasting from 5 to 11 days resulted in long-term survival in 2 patients with post-traumatic gram-negative pneumonitis. The other patients, who had viral pneumonitis and post-transfusion respiratory failure, died after 9 and 11 days of membrane oxygenator support. No embolic lesions or arterial or valvular injuries were discovered at autopsy. This is a safe and useful method of providing oxygenated blood to the aortic root for equal distribution to the rest of the body.
D000328:Adult; D000818:Animals; D001013:Aorta, Thoracic; D001921:Brain / Q000098:blood supply; D002404:Catheterization; D003326:Coronary Circulation; D005112:Extracorporeal Circulation; D005260:Female; D006801:Humans; D008297:Male; D008991:Monitoring, Physiologic; D010100:Oxygen; D010107:Oxygenators, Membrane; D010215:Papio; D010313:Partial Pressure; D010477:Perfusion; D012131:Respiratory Insufficiency / Q000628:therapy*; D013997:Time Factors
D010100:Oxygen