Comparison of in vitro corticosteroid response in pigmentary glaucoma and primary open-angle glaucoma.
We used an in vitro assay utilizing corticosteroids to inhibit transformation of peripheral blood lymphocytes to evaluate a group of 20 patients with pigmentary glaucoma. The pigmentary glaucoma patient group did not manifest the markedly increased cellular sensitivity to corticosteroids associated with primary open-angle glaucoma. If increased sensitivity to corticosteroids plays an essential role in the pathogenesis of primary open-angle glaucoma, then pigmentary glaucoma appears to be etiologically, as well as clinically, a separate entity.
D000328:Adult; D002478:Cells, Cultured; D003864:Depression, Chemical; D003937:Diagnosis, Differential; D005260:Female; D005901:Glaucoma / Q000097:blood / Q000139:chemically induced / Q000175:diagnosis*; D005938:Glucocorticoids / Q000009:adverse effects; D006801:Humans; D066298:In Vitro Techniques; D008213:Lymphocyte Activation / Q000187:drug effects; D008297:Male; D008875:Middle Aged; D010860:Pigments, Biological; D011239:Prednisolone
D005938:Glucocorticoids; D010860:Pigments, Biological; D011239:Prednisolone