Measurement of endometrial blood flow in guinea-pig uterus by clearance of intraluminally applied 133xenon: effects of oophorectomy, estrogen treatment and pregnancy.
Endometrial blood flow (EBF) was studied atraumatically in guinea-pigs by the 133xenon clearance technique. With the aid of an otoscope, a xdnon-saline solution was deposited via the vagina through a cannula into the uterine lumen. Radioactivity curves were obtained by a small external scintillation detector. Oophorectomy lowered total flow wheras this was markedly increased (also per unit weight) by estrogen treatment, alone or in combination with oophorectomy. During early pregnancy there was a tendency to increase in the flow, while the values (for the parietal decidua) were markedly reduced at later stages of pregnancy. In the fetus-placenta unit (133xenon solution injected intra-amniotically) the flow was three times higher than in the parietal decidua at this advanced stage of pregnancy.
D000818:Animals; D001783:Blood Flow Velocity; D002369:Castration; D004717:Endometrium / Q000098:blood supply* / Q000187:drug effects; D004958:Estradiol / Q000494:pharmacology*; D005260:Female; D006168:Guinea Pigs; D008431:Maternal-Fetal Exchange; D011247:Pregnancy; D011868:Radioisotopes; D051381:Rats; D014978:Xenon
D011868:Radioisotopes; D014978:Xenon; D004958:Estradiol