Amino acid constitution of the contraceptive polypeptide from hamster zygotes.
A final separation, on Sephadex G-10, of a biologically active fraction from hamster zygotes has been achieved. The compounds acts to prevent ovulation when it is injected into nonbred hamsters. The active fraction has been analyzed and found to consist of four amino acids: arginine, lysine, proline, and threonine.
D000596:Amino Acids / Q000032:analysis* / Q000302:isolation & purification / Q000494:pharmacology; D000818:Animals; D001120:Arginine / Q000032:analysis; D003271:Contraceptive Agents, Female / Q000032:analysis*; D006224:Cricetinae; D004971:Estrus / Q000187:drug effects*; D005260:Female; D008239:Lysine / Q000032:analysis; D010060:Ovulation / Q000187:drug effects*; D010455:Peptides / Q000032:analysis* / Q000302:isolation & purification / Q000494:pharmacology; D011247:Pregnancy; D011392:Proline / Q000032:analysis; D013912:Threonine / Q000032:analysis; D015053:Zygote / Q000032:analysis*
D000596:Amino Acids; D003271:Contraceptive Agents, Female; D010455:Peptides; D013912:Threonine; D001120:Arginine; D011392:Proline; D008239:Lysine