Antagonistic response of chlorpromazine and formalin in effecting quantitative changes in the neurosecretory material in the teleost Clarias batrachus (L.).
The hypothalamoneurohypophysial complex of Clarias batrachus maintains an appreciable quantity of neurosecretory material (NSM) under normal conditions. Stress caused by the injection of formalin depletes 70-90% of the stainable NSM from all the component parts of the neurosecretory system, namely the nucleus preopticus (NPO) the neurosecretory tract, and the neurohypophysis. Formalin apparently releases the NSM and stimulates the neurons of the NPO. Chlorpromazine (CPZ) treatment seems to cause quantitative increase of NSM throughout the neurosecretory complex. Simultaneous injection of CPZ and formalin showed that the formalin-induced depletion of NSM could be inhibited by CPZ.
D000818:Animals; D002746:Chlorpromazine / Q000494:pharmacology*; D003864:Depression, Chemical; D004336:Drug Antagonism; D005399:Fishes / Q000502:physiology*; D005557:Formaldehyde / Q000494:pharmacology*; D007030:Hypothalamo-Hypophyseal System / Q000187:drug effects*; D009489:Neurosecretion / Q000187:drug effects*
D005557:Formaldehyde; D002746:Chlorpromazine