[Prophylactic and therapeutic action of etimizol on the change in myocardial tissue metabolism in a neurogenic lesion].
The effect of aethimizol, introduced to rabbits before and after inflicting a 3-hours long extraordinary stimulation applied to the reflexogenic zone of the aortic arch, was studied. Investigations covered some aspects of energy metabolism and the level of the norepinephrine mediator in the muscle of the heart and also the functional state of the latter. Aethimizol was found to prevent shifts of the studied metabolic factors, induced by electric stimulation, and also to avert depletion of norepinephrine in the tissue of the myocardium and normalize its function.
D000818:Animals; D009202:Cardiomyopathies / Q000188:drug therapy* / Q000378:metabolism; D004558:Electric Stimulation; D004562:Electrocardiography; D005042:Etimizol / Q000627:therapeutic use*; D006321:Heart / Q000187:drug effects*; D007093:Imidazoles / Q000627:therapeutic use*; D007773:Lactates / Q000032:analysis; D008297:Male; D009206:Myocardium / Q000378:metabolism*; D009638:Norepinephrine / Q000032:analysis; D010725:Phosphocreatine / Q000032:analysis; D010758:Phosphorus / Q000032:analysis; D011817:Rabbits; D013997:Time Factors
D007093:Imidazoles; D007773:Lactates; D010725:Phosphocreatine; D010758:Phosphorus; D005042:Etimizol; D009638:Norepinephrine
Profilakticheskoe i lechebnoe deĭstvie étimizola na izmenenie tkanevogo obmena miokarda pri ego neĭrogennom porazhenii