[Infulence of pyrasanone on the index of articular radioisotope (tc99m) uptake in rheumatoid arthritis].
Objective and instrumental appraisal of the therapeutic effect of a new inflammatory molecule (pyrasanone) via radio-isotope and clinical assessment is reported. A highly significant decrease in articular uptake of radiotechnetium was observed when pyrasanone was administered for a short period to 6 subjects with classic or definite rheumatoid arthritis. Clinical assessment after prolonged aministration in 40 patients with various rheumatic diseases with pathogenetice inflammation showed a marked anc clinically important anti-inflammatory (and hence analgesic) effct; tolerance was good and there were no side-effects.
D000284:Administration, Oral; D000328:Adult; D000368:Aged; D000893:Anti-Inflammatory Agents / Q000008:administration & dosage; D001172:Arthritis, Rheumatoid / Q000188:drug therapy*; D004341:Drug Evaluation; D005260:Female; D006801:Humans; D007596:Joints / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D010653:Phenylbutazone / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000627:therapeutic use*; D013488:Suppositories; D013667:Technetium / Q000378:metabolism
D000893:Anti-Inflammatory Agents; D013488:Suppositories; D013667:Technetium; D010653:Phenylbutazone
Influenza del pyrasanone sull'indice di captazione articolar radioisotopico (99mTc) in corso di artrite reumatoide