Synthesis and antiinflammatory activity of some 2-heteroaryl-alpha-methyl-5-benzoxazoleacetic acids.
The syntheses of eight of the title compounds are described. The compounds possessed activity comparable with that of the previously tested 2-substituted phenyl analogs in the carrageenan-induced rat paw edema test.
D000818:Animals; D000893:Anti-Inflammatory Agents / Q000138:chemical synthesis* / Q000627:therapeutic use; D001583:Benzoxazoles / Q000138:chemical synthesis* / Q000627:therapeutic use; D002351:Carrageenan; D004487:Edema / Q000139:chemically induced / Q000188:drug therapy; D010653:Phenylbutazone / Q000627:therapeutic use; D011422:Propionates / Q000138:chemical synthesis / Q000627:therapeutic use; D051381:Rats
D000893:Anti-Inflammatory Agents; D001583:Benzoxazoles; D011422:Propionates; D002351:Carrageenan; D010653:Phenylbutazone