Deleterious effects of taurine in cats with digitalis-induced arrhythmias.
An established model of digitalis toxicity was used to investigate the antiarrhythmic properties of taurine. I.v. doses of taurine ranging from 0.01 to 4.0 mmole/kg were ineffective in converting a deslanoside-induced arrhythmia to sinus rhythm. Indeed, taurine was found to aggravate the arrhythmia and in three experiments precipitated ventricular fibrillation. In addition, pretreatment with 5 mmole/kg taurine i.v. had no significant effect on the doses of deslanoside to produce ventricular arrhythmia and fibrillation.
D000818:Animals; D001145:Arrhythmias, Cardiac / Q000139:chemically induced* / Q000188:drug therapy; D001794:Blood Pressure / Q000187:drug effects; D002415:Cats; D003892:Deslanoside / Q000494:pharmacology*; D004357:Drug Synergism; D005260:Female; D007799:Lanatosides / Q000494:pharmacology*; D008297:Male; D010634:Phenobarbital / Q000494:pharmacology; D013654:Taurine / Q000009:adverse effects* / Q000627:therapeutic use; D013997:Time Factors; D014693:Ventricular Fibrillation / Q000139:chemically induced
D007799:Lanatosides; D013654:Taurine; D003892:Deslanoside; D010634:Phenobarbital