[Dose-response relationship of bumetanide in healthy subjects].
A diuretic effect is demonstrated following oral administration of 0.25 mg 3-n-butylamino-4-phenoxy-5-sulfamoylbenzoic acid (bumetanide, Burinex-R), the maximum response apparently not being reached by a dose of 0.5 mg. Within this range the dose-response curve is steep and approximately linear. The pattern of urinary volume and electrolyte excretion bears close resemblance to the "high-ceiling" diuretics known so far. Bumetanide differs from them by a markedly increased potency compared on the basis of molar dosage.
D000328:Adult; D002034:Bumetanide / Q000008:administration & dosage / Q000494:pharmacology*; D002118:Calcium / Q000652:urine; D002712:Chlorides / Q000652:urine; D004232:Diuretics / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D005260:Female; D006801:Humans; D008274:Magnesium / Q000652:urine; D008297:Male; D008875:Middle Aged; D011188:Potassium / Q000652:urine; D012964:Sodium / Q000652:urine
D002712:Chlorides; D004232:Diuretics; D002034:Bumetanide; D012964:Sodium; D008274:Magnesium; D011188:Potassium; D002118:Calcium
Dosis-Wirkungs-Beziehung von Bumetanid bei gesunden Probanden