Complement dependence of localisation of aggregated IgG in germinal centres.
In vivo decomplementation of mice with cobra factor completely prevented trapping of aggregated human IgG within splenic germinal centres. Observations of the intrasplenic position of the aggregated material within 8 hr of its injection into normal and decomplemented mice suggest that the early phase of localisation in germinal centres depends on binding to lymphocyte C3 receptors.
D000818:Animals; D001665:Binding Sites; D003176:Complement C3 / Q000378:metabolism*; D003165:Complement System Proteins / Q000378:metabolism*; D005260:Female; D005854:Germ Cells / Q000276:immunology*; D006358:Hot Temperature; D007074:Immunoglobulin G / Q000378:metabolism*; D007274:Injections, Intraperitoneal; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D012910:Snake Venoms / Q000008:administration & dosage / Q000494:pharmacology; D013154:Spleen / Q000276:immunology*
D003176:Complement C3; D007074:Immunoglobulin G; D012910:Snake Venoms; D003165:Complement System Proteins