Microbiological degradation of diazepam.
In studying the transformation of diazepam (7-chloro-1-methyl-5-phenyl-1,3-dihydro-2H-1,4-benzodiazepin-2-one) by fungi isolated from soil. N1-demethylation and cleavage of the diazepine ring were observed. Three metabolites: 7-chloro-5-phenyl-1,3-dihydro-2H-1,4-benzodiazepin-2-one, 2-acetamido-2"-benzoyl-4"-chloroacetanilide and 2-acetamido-2"-benzoyl-4"-chloro-N-methylacetanilide were isolated and identified.
D000083:Acetanilides / Q000031:analogs & derivatives / Q000096:biosynthesis; D001230:Aspergillus / Q000378:metabolism; D001570:Benzodiazepinones / Q000096:biosynthesis; D001673:Biodegradation, Environmental; D055598:Chemical Phenomena; D002621:Chemistry; D002855:Chromatography, Thin Layer; D003975:Diazepam / Q000378:metabolism*; D005285:Fermentation; D005658:Fungi / Q000378:metabolism*; D006868:Hydrolysis; D013058:Mass Spectrometry; D003904:Mitosporic Fungi / Q000378:metabolism; D009090:Mucorales / Q000378:metabolism; D010407:Penicillium / Q000378:metabolism; D012233:Rhizopus / Q000378:metabolism; D012988:Soil Microbiology; D013055:Spectrophotometry, Infrared
D000083:Acetanilides; D001570:Benzodiazepinones; D003975:Diazepam