Familial pseudomembranous colitis and its relation to lincomycin therapy.
Severe pseudomembranous colitis was observed in 3 members of a single family: the father and 2 of his children. 2 of the affected family members received the antibiotic lincomycin prior to the onset of their symptoms. The findings in this family raise the possibility that antibiotic-induced pseudomembranous colitis in some patients may be the result of a pharmacogenetic interaction.
D000293:Adolescent; D000328:Adult; D002648:Child; D004761:Enterocolitis, Pseudomembranous / Q000139:chemically induced / Q000235:genetics*; D005260:Female; D006801:Humans; D008034:Lincomycin / Q000009:adverse effects*; D008297:Male; D010375:Pedigree
D008034:Lincomycin