[Technetium polyphosphate and technetium diphosphonate. A comparative study].
99mTc-labelled phosphates are the bone seeking agents of choice. The comparison of 99mTc-polyphosphate (Poly-P) and 99mTc-ethane-1-hydroxy-1,1-diphosphonate (EHDP) shows a better in vitro stability of the latter during the first two hours after preparation. The blood clearance of EHDP is superior to Poly-P resulting in reduced background activity at scanning time. Renal excretion over a 4-hour period of urine sampling showed no significant differences between both substances. Blood activity is independent of diuresis.
D000328:Adult; D001847:Bone Diseases / Q000175:diagnosis*; D001859:Bone Neoplasms / Q000175:diagnosis; D001943:Breast Neoplasms; D004231:Diuresis; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009362:Neoplasm Metastasis; D009943:Organophosphorus Compounds / Q000378:metabolism; D010386:Pelvic Neoplasms / Q000175:diagnosis; D010710:Phosphates / Q000378:metabolism; D011877:Radionuclide Imaging / Q000379:methods*; D013667:Technetium / Q000097:blood / Q000378:metabolism / Q000652:urine; D013997:Time Factors
D009943:Organophosphorus Compounds; D010710:Phosphates; D013667:Technetium
Technetiumpolyphosphate und Technetiumdiphosphonat. Eine vergleichende Untersuchung