Capacity of contact cytotoxic reaction to distinguish targets presented by F1 and somatic hybrid cells of the same H-2 parentage.
51Cr-release from prelabelled target cells caused by contact with effector lymphocytes was greater when the H-2d/H-2k cells used for sensitization (i.e. production of effector cells) were also phenotypically similar to the target cells. The contact cytotoxic reaction thus turned out to be sensitive enough to distinguish a putative phenotypic difference between F1 and somatic hybrid cells of the same H-2 parentage. A possible involvement of non-H-2 differences was controlled and ruled out.
D000818:Animals; D003601:Cytotoxicity Tests, Immunologic; D006649:Histocompatibility Antigens; D006822:Hybrid Cells; D008214:Lymphocytes / Q000276:immunology*; D051379:Mice; D010641:Phenotype
D006649:Histocompatibility Antigens