Observations on the systemic effect of topical clobetasol propionate (Dermovate).
Topical application of clobetasol propionate in a strength of 0-05% in cream or ointment (Dermovate) suppressed the hypothalamic-pituitary-adrenal axis in both normal people and patients with diseased skin. In normal people the 9 am serum cortisol level was suppressed when between 45 and 90 g was applied weekly. Insulin stress test results in patients with diseased skin showed an abnormally small response after long-term application of similar amounts. We conclude that long-term administration should be restricted to less than 50 g a week.
D000311:Adrenal Glands / Q000187:drug effects*; D000328:Adult; D001623:Betamethasone / Q000008:administration & dosage / Q000009:adverse effects / Q000031:analogs & derivatives*; D001786:Blood Glucose; D006801:Humans; D006854:Hydrocortisone / Q000097:blood; D007030:Hypothalamo-Hypophyseal System / Q000187:drug effects*; D007328:Insulin; D008297:Male; D009824:Ointments; D012871:Skin Diseases / Q000503:physiopathology
D001786:Blood Glucose; D007328:Insulin; D009824:Ointments; D001623:Betamethasone; D006854:Hydrocortisone