Effects of concanavalin A on the isolated perfused rat liver.
In the isolated perfused liver, Concanavalin A provoked a significant decrease of flow rate within 2 to 4 min. which was dose-dependent and could be partly inhibited by specific antagonists. Furthermore it was found that the lectin led to a decline of the respiration, an increase of the lactate/pyruvate ratio and a release of the transaminases into the medium. It was suggested that Concanavalin A displaced endothelial cells in the liver capillaries, which occluded the vessels and decreased the flow rate. The decreased respiration was considered to be secondary to this effect.
D000818:Animals; D002462:Cell Membrane / Q000187:drug effects; D003208:Concanavalin A / Q000494:pharmacology*; D006023:Glycoproteins / Q000502:physiology; D066298:In Vitro Techniques; D008099:Liver / Q000166:cytology / Q000187:drug effects* / Q000648:ultrastructure; D008102:Liver Circulation / Q000187:drug effects; D008297:Male; D010101:Oxygen Consumption / Q000187:drug effects; D010477:Perfusion; D051381:Rats; D011955:Receptors, Drug / Q000187:drug effects; D013997:Time Factors
D006023:Glycoproteins; D011955:Receptors, Drug; D003208:Concanavalin A