A new antibiotic, fumaramidmycin. II. Isolation, structure and syntheses.
A new antibiotic fumaramidmycin produced by Streptomyces kurssanovii NR-7GG1 was isolated as colorless crystals. The structure was shown to be N-(phenylacetyl) fumaramide. Starting from fumaramic acid, fumaramidmycin has been synthesized in good yield, in which the key stage involves N-acylated imino ether formation followed by mild acid hydrolysis. Five analogues of fumaramidmycin have also been prepared.
D000900:Anti-Bacterial Agents / Q000302:isolation & purification*; D005650:Fumarates / Q000302:isolation & purification; D007094:Imides; D008968:Molecular Conformation; D010648:Phenylacetates / Q000302:isolation & purification; D013057:Spectrum Analysis; D013302:Streptomyces / Q000378:metabolism
D000900:Anti-Bacterial Agents; D005650:Fumarates; D007094:Imides; D010648:Phenylacetates