[Effect of gamma-aminobutyric acid and phenibut on the central links of the vascular reflexes with chemo- and mechanoreceptors of the aorto-carotid zone].
Experiments were conducted on decerebrated cats. A depressive effect of gamma-aminobutyruc acid (GABA)--100--200 mg/kg and its phenyl derivative phenibut--20 mg/kg--on depressive reactions of the systemic arterial pressure and on the inhibition of spontaneous bioelectrical activity in the renal nerve occurring in stimulation of the mechanoreceptors of the carotid sinus and of the sinus and depressor nerve afferents (having a mechanoreceptor modality) was demonstrated. Pressor reactions of the systemic arterial pressure and evoked bioelectrical activity were enhanced in the renal nerve in stimulation of chemoreceptors of the carotid sinus following administration of the same GABA and phenibut doses. The data obtained are interpreted from the aspect of a deprimating action of GABA and phenibut in the area of the paramedian reticular nuclei of the medulla oblongata.
D000613:Aminobutyrates / Q000494:pharmacology*; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D002346:Carotid Sinus / Q000187:drug effects*; D002415:Cats; D003864:Depression, Chemical; D005071:Evoked Potentials; D008526:Medulla Oblongata / Q000187:drug effects*; D010654:Phenylbutyrates / Q000494:pharmacology*; D011311:Pressoreceptors / Q000187:drug effects*; D012018:Reflex / Q000187:drug effects*; D005680:gamma-Aminobutyric Acid / Q000031:analogs & derivatives / Q000494:pharmacology*
D000613:Aminobutyrates; D010654:Phenylbutyrates; D005680:gamma-Aminobutyric Acid
Deĭstvie gamma-aminomaslianoĭ kisloty i fenibuta na tsentral'nye zven'ia sosudistykh refleksov s khemo- i mekhanoretseptorov aorto-karotidnoĭ zony