Lincomycin-curare interaction.
After observing a case of lincomycin (LCN)-induced respiratory insufficiency in a patient recovering from d-tubocurarine (DTC) administration, this interaction was studied in cats anesthetized with halothane-nitrous-oxide-oxide-oxygen. The sciatic nerve was stimulated with a 1.6-second tetanci train of 62.5 Hz every 10 seconds. The area under the contraction curve was electronically integrated and recorded. Five control cats received 0.01 mg/kg DTC every 2 minutes until time-tension integral response (TTIR) was zero. Five experimental cats received 10 mg/kg of LCN followed in 10 minutes by 0.01 mg/kg of DTC every 2 minutes until TTIR was zero. Both groups recovered to 50 per cent of control and were given 10 mg/kg of LCN. There was no difference between the slope of the y-intercept of the regression lines for the log-dose response curves for DTC in the two groups. LCN during recovery from DTC had a statist "Intermittent mandatory ventilation in the treatment of patients with chronic obstructive pulmonary disease".
D000769:Anesthesia, Inhalation; D000818:Animals; D002415:Cats; D003472:Curare / Q000009:adverse effects / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D004347:Drug Interactions; D004558:Electric Stimulation; D006221:Halothane; D006801:Humans; D008034:Lincomycin / Q000009:adverse effects / Q000494:pharmacology*; D009609:Nitrous Oxide; D010100:Oxygen; D012133:Respiratory Paralysis / Q000139:chemically induced; D012584:Sciatic Nerve / Q000187:drug effects*; D013997:Time Factors
D003472:Curare; D008034:Lincomycin; D009609:Nitrous Oxide; D010100:Oxygen; D006221:Halothane