Stimulatory effect of the lysosomal stabilizer, chloroquine, on the respiration and motility of fresh and aged bovine spermatozoa.
The lysosomal stabilizer and anti-malarial agent, chloroquine, stimulated the respiration and motility of fresh and aged bovine spermatozoa stored in vitro. Duplication of these effects by the phosphodiesterase inhibitors, theophylline and caffeine, suggested that enhancement of sperm activity by chloroquine may be mediated by cyclic AMP.
D000818:Animals; D002110:Caffeine / Q000494:pharmacology; D002417:Cattle; D002738:Chloroquine / Q000494:pharmacology*; D066298:In Vitro Techniques; D008297:Male; D010101:Oxygen Consumption / Q000187:drug effects; D013081:Sperm Motility / Q000187:drug effects; D013082:Sperm Tail / Q000187:drug effects; D013094:Spermatozoa / Q000187:drug effects* / Q000378:metabolism; D013268:Stimulation, Chemical; D013806:Theophylline / Q000494:pharmacology; D014021:Tissue Preservation
D002110:Caffeine; D002738:Chloroquine; D013806:Theophylline