Hexamitiasis in cadmium-exposed mice.
Mortality was observed in 4- to 5-week-old Swiss Webster mice exposed to 300 or 3 ppm cadmium as cadmium chloride in the drinking water. Mice receiving 300 ppm cadium suffered 26% mortality as compared with 7% of those on the low cadmium dose. Death did not occur in control mice. Clinical signs and histopathology established Hexamita muris as the causative agent. Cadmium lesions were not observed. It is suggested that mortality due to hexamitiasis resulted from synergism between cadmium and H muris.
D000818:Animals; D000917:Antibody Formation / Q000187:drug effects; D002104:Cadmium / Q000633:toxicity*; D004305:Dose-Response Relationship, Drug; D004781:Environmental Exposure; D056890:Eukaryota; D051379:Mice; D011528:Protozoan Infections / Q000209:etiology / Q000401:mortality; D011529:Protozoan Infections, Animal; D012376:Rodent Diseases / Q000139:chemically induced / Q000209:etiology* / Q000401:mortality; D014881:Water Supply
D002104:Cadmium