[Effect of pyrimidine amino acid derivatives on vaccinia virus in tissue culture].
The results of the study of antiviral properties of 9 derivatives of pyrimidine amino acids showed only N-(2-chloro-5-bromopyrimidil-4)-1-leucin to possess marked antiviral properties manifested in the capacity of this compound to inhibit the vaccinia virus DNA synthesis in chick embryo fibroblast culture and, consequently, to reduce the infections activity of the virus. All the other derivatives of this class have no marked antiviral properties.
D000596:Amino Acids / Q000494:pharmacology; D000818:Animals; D000998:Antiviral Agents / Q000494:pharmacology*; D002250:Carbon Radioisotopes; D002642:Chick Embryo; D004247:DNA / Q000096:biosynthesis; D005347:Fibroblasts; D011743:Pyrimidines / Q000494:pharmacology*; D013936:Thymidine; D014616:Vaccinia virus / Q000187:drug effects*; D014779:Virus Replication / Q000187:drug effects*
D000596:Amino Acids; D000998:Antiviral Agents; D002250:Carbon Radioisotopes; D011743:Pyrimidines; D004247:DNA; D013936:Thymidine
Izuchenie deĭstviia nekotorykh proizvodnykh pirimidinovykh aminokislot na virus ospovaktsiny v kul'ture tkani