The quantitative determination of griseofulvin by gas chromatography (ECD-GC).
Serum and organ griseofulvin levels in guinea pigs and serum levels in patients who received a prolonged oral administration of griseofulvin were determined gas-chromatographically. In guinea pigs liver showed the highest concentration of griseofulvin, followed by kidney and serum in the decreasing order. The skin levels were 0.16 approximately 1.51 mug/g with a dose of 30 mg/kg. In humans it was proved that griseofulvin did not cause any accumulation in the serum with a dosage of 500 mg/day.
D000284:Administration, Oral; D000328:Adult; D000368:Aged; D000818:Animals; D001923:Brain Chemistry; D002849:Chromatography, Gas; D006118:Griseofulvin / Q000008:administration & dosage / Q000032:analysis* / Q000097:blood; D006168:Guinea Pigs; D006801:Humans; D007668:Kidney / Q000032:analysis; D008099:Liver / Q000032:analysis; D008168:Lung / Q000032:analysis; D008875:Middle Aged; D012867:Skin / Q000032:analysis; D013997:Time Factors
D006118:Griseofulvin