Effect of intravenous frusemide on plasma renin concentration: suppression of response in hypertension.
1. Intravenous frusemide produced in normal subjects a prompt rise of plasma renin concentration which correlated with urinary sodium. 2. The renin response to frusemide was suppressed in patients with primary hyperaldosteronism. 3. In patients with low-renin hypertension and normal renin essential hypertension, the renin response to frusemide was similarly suppressed. 4. Suppression of the renin response to frusemide is therefore a feature of hypertension not confined to patients with primary hyperaldosteronism and low-renin hypertension. 5. Thus low-renin hypertension does not appear to constitute a distinct diagnostic entity. 6. It is suggested that suppression of the renin response is part of a long-term renal adaptation to high blood pressure.
D000328:Adult; D000368:Aged; D005260:Female; D005665:Furosemide / Q000494:pharmacology*; D006801:Humans; D006929:Hyperaldosteronism / Q000097:blood; D006973:Hypertension / Q000097:blood* / Q000652:urine; D008297:Male; D008875:Middle Aged; D012083:Renin / Q000097:blood*; D012964:Sodium / Q000652:urine
D005665:Furosemide; D012964:Sodium; D012083:Renin