Inhibition of furosemide-induced renin release by vasoconstrictors.
The effect of i.v. infused (asp1-beta-amid, val5)-angiotensin II (1.0 mug/kg min), octapressin (phe2, lys8-vasopressin) (10.0 mU/kg min) and of the alpha-sympathomimetic amine phenylephrine (40.0 mug/kg min) on the stimulation of renin secretion by furosemide (10.0 mg/kg i.v.) was investigated. The vasoconstrictors abolished the renin release induced by forosemide. Studies on the clearance of p-aminohippuric acid (PAH) (i.e. renal plasma flow) showed that the action of the vasoconstrictors cannot be explained by a decrease in access of furosemide to its intrarenal sites of action. The mechanism of the suppressive action of the vasoconstrictors on renin release is discussed.
D000618:Aminohippuric Acids / Q000652:urine; D000804:Angiotensin II / Q000494:pharmacology; D000818:Animals; D005259:Felypressin / Q000494:pharmacology; D005665:Furosemide / Q000037:antagonists & inhibitors* / Q000494:pharmacology; D007668:Kidney / Q000098:blood supply; D008297:Male; D010656:Phenylephrine / Q000494:pharmacology; D051381:Rats; D012039:Regional Blood Flow / Q000187:drug effects; D012083:Renin / Q000097:blood / Q000378:metabolism*; D014662:Vasoconstrictor Agents / Q000494:pharmacology*
D000618:Aminohippuric Acids; D014662:Vasoconstrictor Agents; D000804:Angiotensin II; D010656:Phenylephrine; D005259:Felypressin; D005665:Furosemide; D012083:Renin