Evaluation of dithranol and a 'synthetic tar' as anti-psoriatic treatments using the mouse tail test.
Dithranol and 'Psorox' were evaluated for granular layer induction in parakeratotic regions of mouse tail skin. The lack of this specific activity suggests that they both have different primary actions in the healing psoriatic lesion.
D000818:Animals; D000873:Anthracenes / Q000627:therapeutic use*; D000875:Anthralin / Q000627:therapeutic use*; D002227:Carbazoles / Q000627:therapeutic use; D003408:Cresols / Q000627:therapeutic use; D051379:Mice; D009281:Naphthalenes / Q000627:therapeutic use; D010616:Phenanthrenes / Q000627:therapeutic use; D010636:Phenols / Q000627:therapeutic use; D010847:Picolines / Q000627:therapeutic use; D011565:Psoriasis / Q000188:drug therapy*; D011725:Pyridines / Q000627:therapeutic use; D011804:Quinolines / Q000627:therapeutic use; D012867:Skin / Q000187:drug effects; D013638:Tars / Q000627:therapeutic use*; D014050:Toluene / Q000627:therapeutic use; D014992:Xylenes / Q000627:therapeutic use
D000873:Anthracenes; D002227:Carbazoles; D003408:Cresols; D009281:Naphthalenes; D010616:Phenanthrenes; D010636:Phenols; D010847:Picolines; D011725:Pyridines; D011804:Quinolines; D013638:Tars; D014992:Xylenes; D014050:Toluene; D000875:Anthralin