DiC-like syndrome after envenomation by the snake, Crotalus horridus horridus.
After envenomation by the timber rattlesnake (Crotalus horridus horridus) a young man showed massive swelling and ecchymoses of the involved extremity, generalized petechiae and a large hematoma of the left upper eyelid. Two weeks later he was completely well. The first blood sample was incoagulable and showed high titers of fibrin split products by the MISFI and staphylococcal clumping tests. Immounoelectrophoresis showed both D and E fragments, but only D was present at 18 hours. The profound thrombocytopenia and hypofibrinogenemia gradually improved, and split products disappeared. In vitro the venom had thrombin-like activity, clotting fibrinogen or plasma and aggregating platelets. These activities could be inhibited by antivenom but not by heparin. There was no evidence that thrombin formation was actually involved: hence, the syndrome is called DIC-like.
D000328:Adult; D000347:Afibrinogenemia / Q000209:etiology; D000818:Animals; D000997:Antivenins / Q000627:therapeutic use; D001777:Blood Coagulation / Q000187:drug effects; D004211:Disseminated Intravascular Coagulation / Q000188:drug therapy / Q000209:etiology*; D005337:Fibrin / Q000032:analysis; D006493:Heparin / Q000627:therapeutic use; D006801:Humans; D066298:In Vitro Techniques; D008297:Male; D010974:Platelet Aggregation / Q000187:drug effects; D012909:Snake Bites / Q000097:blood / Q000150:complications* / Q000188:drug therapy; D012910:Snake Venoms / Q000494:pharmacology; D012911:Snakes; D013917:Thrombin / Q000494:pharmacology; D013921:Thrombocytopenia / Q000209:etiology
D000997:Antivenins; D012910:Snake Venoms; D005337:Fibrin; D006493:Heparin; D013917:Thrombin