[Experimental study of the embryotropic action of tetracycline].
The general toxic and embryotropic effect of tetracycline was studied on unbred pregnant albino rats. The antibiotic was used in concentrations of 1 and 0.1 mg/m3, the maximum permissible concentration (MPC). The animals were exposed to tetracycline inhalation for 20 days of their pregnancy. On the basis of the results it was concluded that tetracycline in the concentration at the level of the MPC, i.e. 0.1 mg/m3 had under the experimental conditions a negative effect on the pregnant animals. In concentrations of 1 and 0.1 mg/m3 it had in addition an embryotropic effect. It was also shown that the pregnant animals were more sensitive to the antibiotic than the non-pregnant ones.
D000818:Animals; D003338:Corpus Luteum / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D010064:Embryo Implantation / Q000187:drug effects; D004622:Embryo, Mammalian / Q000187:drug effects*; D004781:Environmental Exposure; D005260:Female; D005313:Fetal Death / Q000139:chemically induced; D005333:Fetus / Q000187:drug effects; D009929:Organ Size; D010920:Placenta / Q000187:drug effects; D011247:Pregnancy; D051381:Rats; D013752:Tetracycline / Q000494:pharmacology* / Q000633:toxicity; D013997:Time Factors
D013752:Tetracycline
Eksperimental'noe issledovanie émbriotropnogo deĭstviia tetratsiklina