Cushing's syndrome associated with a bronchial adenoma. Possible periodic hormonogenesis.
Diagnostic and therapeutic problems in a patient with ectopic ACTH syndrome caused by a malignant bronchial adenoma are discussed. Persistent Cushing's syndrome was present following apparent total adrenalectomy, but radioactive scanning with 131I-19-iodocholesterol showed the presence of residual adrenal tissue in the right suprarenal bed. Amelioration of the hypercortisolism occurred after removal of the bronchial adenoma. A paradoxical elevation of adrenocortical activity followed administration of dexamethasone and data are presented which suggest that periodic secretion of ACTH accounted for this phenomenon.
D000236:Adenoma / Q000150:complications* / Q000601:surgery; D000315:Adrenalectomy; D000328:Adult; D000616:Aminoglutethimide / Q000009:adverse effects / Q000627:therapeutic use; D001984:Bronchial Neoplasms / Q000150:complications* / Q000601:surgery; D003480:Cushing Syndrome / Q000188:drug therapy / Q000209:etiology*; D003907:Dexamethasone / Q000627:therapeutic use; D006801:Humans; D008297:Male; D008939:Mitotane / Q000009:adverse effects / Q000627:therapeutic use; D009384:Paraneoplastic Endocrine Syndromes / Q000175:diagnosis / Q000188:drug therapy
D000616:Aminoglutethimide; D008939:Mitotane; D003907:Dexamethasone