A study of genetic factors, childhood bereavement, and premorbid personality traits in patients with anancastic endogenous depression.
From a sample of 1,005 patients admitted to the State Hospital in Aarhus for the first time during the period 1950-1959 and who had been diagnosed as suffering from manic-depressive psychosis or endogenous depression (affective psychoses), a subsample of 104 manic-depressive aptients with anancastic symptoms in the history were selected. The 104 probands were individually matched with 104 non-anancastic probands with affective psychoses. The anancastic probands and the controls who were still living were seen personally at the follow-up. Information concerning the psychiatric history of 945 first degree relatives of the anancastic probands and 1,000 first degree relatives of the controls were obtained. During the search for factors which could be used to distinguish affective psychoses with anancastic symptoms from affective psychoses without these traits, a positive correlation was found between the presence of anancasma and the following factors: (a) premorbid obsessive personality traits; (b) traumatic environmental factors in childhood; (c) a tendency to monopolarity; (d) a preponderance of monopolar depressions in the family; (e) the presence of secondary cases of anancastic endogenous depression. The findings are compatible with a theory which attributes a pathoplastic effect to the obsessive personality giving rise to anancastic symptomatology in the form of affective psychoses which tend to a unipolar course.
D000342:Affective Symptoms / Q000175:diagnosis; D001714:Bipolar Disorder / Q000175:diagnosis* / Q000235:genetics; D002657:Child Development; D003193:Compulsive Personality Disorder; D003718:Denmark; D003863:Depression / Q000175:diagnosis; D003937:Diagnosis, Differential; D004781:Environmental Exposure; D005500:Follow-Up Studies; D006801:Humans; D010287:Parent-Child Relations; D010551:Personality; D010554:Personality Disorders; D012189:Retrospective Studies; D012931:Social Environment