Cortisol-induced lymphocytolysis of P1798 tumor cells in glucose-free, pyruvate-free medium.
Exposure of corticoid-sensitive P1798 tumor lymphocytes to cortisol resulted in progressive cell dissolution either with or without exogenous glucose and pyruvate. Therefore, inhibition of glucose transport is not required for cortisol-induced lymphocytolysis.
D000818:Animals; D005260:Female; D005947:Glucose / Q000378:metabolism; D006854:Hydrocortisone / Q000494:pharmacology*; D066298:In Vitro Techniques; D008214:Lymphocytes / Q000187:drug effects*; D008228:Lymphoma, Non-Hodgkin; D051379:Mice; D008807:Mice, Inbred BALB C; D009374:Neoplasms, Experimental; D011773:Pyruvates / Q000378:metabolism
D011773:Pyruvates; D005947:Glucose; D006854:Hydrocortisone