Cytotoxic and mutagenic effects of carcinogenic aromatic amides and polycyclic hydrocarbons and ultraviolet irradiation in normally repairing and repair-deficient (xeroderma pigmentosum) diploid human skin fibroblasts.
The cloning ability of fibroblasts taken from a xeroderma pigmentosum patient proved 2.5-3.5 times more sensitive to the cytotoxic effect of active derivatives of carcinogens or to UV irradiation than that of normal cells. They also exhibited a corresponding 2.5- to 2.5-fold greater increase in the frequency of induced mutations to 8-azaguanine resistance per survivor, which might have been expected since these XP cells exhibit less than 20% of the DNA-repairing capacity of the normal cells following exposure to such DNA-damaging agents.
D000577:Amides / Q000494:pharmacology*; D002273:Carcinogens / Q000494:pharmacology*; D002470:Cell Survival / Q000528:radiation effects; D004171:Diploidy; D005347:Fibroblasts / Q000187:drug effects / Q000378:metabolism / Q000528:radiation effects; D011083:Polycyclic Compounds / Q000494:pharmacology*; D011830:Radiation Effects; D012867:Skin / Q000187:drug effects / Q000378:metabolism / Q000528:radiation effects*; D014466:Ultraviolet Rays; D014983:Xeroderma Pigmentosum / Q000378:metabolism*
D000577:Amides; D002273:Carcinogens; D011083:Polycyclic Compounds