[Radioautographic study of the action of androgens on the synthesis of nucleic acids in the male genital tract of the white mouse (author's transl)].
A comparison was made, by autoradiographic studies, of the nucleic acids synthesis in the target organs of the male hormone, in normal mice, castrate and castrated mice with an implantation of a testosterone pellet. The results show that the response of each of these organs, to a physiological supply of hormone or to a supraphysiological supply is quite different, both in intensity and in evolution. The differences are still apparent in castrated animals. The transfer of RNA from the nucleus to the cytoplasm seems to be affected by the castration. The signification of these results is discussed.
D000818:Animals; D001345:Autoradiography; D002369:Castration; D003562:Cytidine / Q000378:metabolism; D004247:DNA / Q000096:biosynthesis*; D003692:Delayed-Action Preparations; D004822:Epididymis / Q000378:metabolism; D005837:Genitalia, Male / Q000187:drug effects / Q000378:metabolism*; D008297:Male; D051379:Mice; D011467:Prostate / Q000378:metabolism; D012313:RNA / Q000096:biosynthesis*; D012669:Seminal Vesicles / Q000378:metabolism; D013739:Testosterone / Q000008:administration & dosage / Q000494:pharmacology*; D013936:Thymidine / Q000378:metabolism; D014649:Vas Deferens / Q000378:metabolism
D003692:Delayed-Action Preparations; D013739:Testosterone; D003562:Cytidine; D012313:RNA; D004247:DNA; D013936:Thymidine
Action des androgènes sur la synthèse des acides nucléiques dans le tractus génital mâle de la souris blanche. Analyse autoradiographique