Chemotherapeutic studies on Litomosoides carinii infection of Mastomys natalensis. 6. The filaricidal activity of organophosphorus compounds.
Several organophosphorus compounds have been evaluated for their efficacy against micro- and macrofilariae in experimental investigations on Litomosoides carinii infection in the multimammate rat Mastomys natalensis. The anthelmintic haloxon proved to be the most effective compound with high activity against microfilariae and a favourable chemotherapeutic range. The organophosphates fenthion, Dursban, metrifonate, coumaphos, crufomate and naphthalophos also showed pronounced microfilaricidal activity but with different and lower chemotherapeutic indices. The preparations chlorfenvinphos, benoxafos, cythioate and imidan proved to be without marked microfilaricidal action at tolerable dose schedules. The organophosphorus compounds did not show any influence on the mobility or viability of the adult worms of Litomosoides carinii.
D000818:Animals; D000871:Anthelmintics; D004049:Diethylcarbamazine / Q000627:therapeutic use; D005368:Filariasis / Q000188:drug therapy*; D005369:Filaricides; D005370:Filarioidea / Q000187:drug effects*; D008842:Microfilariae / Q000187:drug effects*; D009943:Organophosphorus Compounds / Q000627:therapeutic use*; D009946:Organothiophosphorus Compounds / Q000627:therapeutic use; D051381:Rats; D013045:Species Specificity
D000871:Anthelmintics; D005369:Filaricides; D009943:Organophosphorus Compounds; D009946:Organothiophosphorus Compounds; D004049:Diethylcarbamazine