Observations of gastric mucosal blood flow using 99Tcm in rat and man.
The 99Tcm clearance technique is shown to be a useful method of assessing gastric function. It is easily carried out and is relatively non-toxic--the dose of isotope could be reduced to 100 muCi or less without sacrificing the accuracy of the investigation. Although the results are preliminary and the number of cases investigated so far is small, they suggest that the measurement of pertechnetate clearance is directly related to gastric mucosal blood flow; it is a useful parameter of gastric function and may well prove to be a more accurate discriminant in cases of peptic ulceration than the conventional measurement of gastric acid secretion.
D000632:Aminopyrine / Q000378:metabolism; D000818:Animals; D004381:Duodenal Ulcer / Q000175:diagnosis / Q000503:physiopathology; D005750:Gastric Juice / Q000378:metabolism; D005753:Gastric Mucosa / Q000098:blood supply* / Q000187:drug effects / Q000378:metabolism; D006801:Humans; D010418:Pentagastrin; D011803:Quinine / Q000378:metabolism; D011877:Radionuclide Imaging / Q000379:methods*; D051381:Rats; D013276:Stomach Ulcer / Q000175:diagnosis / Q000503:physiopathology; D013667:Technetium
D000632:Aminopyrine; D013667:Technetium; D011803:Quinine; D010418:Pentagastrin