Dichlorvos effects on estrous cycle onset in the rat.
Continuous exposure to dichlorvos (DDVP) vapors from birth in rats caused a statistically significant mean delay of 10 da in the onset of the first estrous cycle. DDVP, BUT NOT ITS PRIMARY METABOLITE (DES-METHYL DDVP), could be readily isolated from blood and ovarian tissue, and occassionally in minute quantities from the kidney and adrenal tissues. DDVP was recovered only once in 40 brain tissue samples examined.
D000311:Adrenal Glands / Q000378:metabolism; D000818:Animals; D001921:Brain / Q000378:metabolism; D004006:Dichlorvos / Q000097:blood / Q000378:metabolism / Q000494:pharmacology*; D004971:Estrus / Q000187:drug effects*; D005260:Female; D007668:Kidney / Q000378:metabolism; D008297:Male; D010053:Ovary / Q000378:metabolism; D011247:Pregnancy; D051381:Rats / Q000502:physiology*; D013997:Time Factors; D014626:Vaginal Smears
D004006:Dichlorvos