Ph1-positive megakaryoblastic leukemia.
A case of megakaryoblastic leukemia is presented. Megakaryoblastosis and erythrocytic hyperplasia of the bone marrow, thrombocythemia, and hepatosplenomegaly were the essential features; 100% of the marrow-derived metaphases were found to be Ph1-positive. Cytologic and chromosomal findings are compatible with the assumption that all three marrow systems were involved in the leukemic process.
D000208:Acute Disease; D001345:Autoradiography; D001772:Blood Cell Count; D001792:Blood Platelets; D001853:Bone Marrow / Q000473:pathology; D002330:Carmustine / Q000627:therapeutic use; D002869:Chromosome Aberrations; D002902:Chromosomes, Human, 16-18; D002903:Chromosomes, Human, 19-20; D002904:Chromosomes, Human, 21-22 and Y; D002906:Chromosomes, Human, 6-12 and X; D003561:Cytarabine / Q000627:therapeutic use; D005260:Female; D006801:Humans; D008198:Lymph Nodes / Q000473:pathology; D008533:Megakaryocytes; D008875:Middle Aged; D008938:Mitosis; D011014:Pneumonia / Q000209:etiology; D013866:Thioguanine / Q000627:therapeutic use; D013920:Thrombocythemia, Essential / Q000188:drug therapy / Q000235:genetics* / Q000473:pathology; D014750:Vincristine / Q000627:therapeutic use
D003561:Cytarabine; D014750:Vincristine; D013866:Thioguanine; D002330:Carmustine