Inhibition of synaptosomal accumulation of l-norepinephrine. I: N-arylalkyl and N-aryloxyalkyl dl-amphetamines and related compounds.
The ability of a group of systematically modified amphetamines to inhibit the accumulation of l-norepinephrine by nonstriatal synaptosomes was investigated. N-Substitution by the proper bulky hydrophobic groups can be well tolerated. Structure-activity relationships generate a qualitative picture of the inhibitor-carrier interaction site.
D000662:Amphetamines / Q000138:chemical synthesis / Q000494:pharmacology*; D000818:Animals; D001921:Brain / Q000378:metabolism / Q000648:ultrastructure; D001923:Brain Chemistry / Q000187:drug effects; D003864:Depression, Chemical; D005374:Filtration; D066298:In Vitro Techniques; D008297:Male; D009638:Norepinephrine / Q000378:metabolism*; D051381:Rats; D013574:Synaptosomes / Q000187:drug effects / Q000378:metabolism*
D000662:Amphetamines; D009638:Norepinephrine