Testicular endocrine function and cyclophosphamide in prepubertal and pubertal patients.
Testicular function was examined by means of HCG-stimulation tests in 6 prepubertal or pubertal patients with leukemia or malignant tumours during cytostatic therapy and in 5 patients with nephrotic syndrome after discontinuation of treatment. The results of urinary testosterone assays suggest no damaging effect of cyclophosphamide on Leydig cell function.
D000293:Adolescent; D000367:Age Factors; D002648:Child; D002675:Child, Preschool; D006063:Chorionic Gonadotropin / Q000494:pharmacology; D003520:Cyclophosphamide / Q000494:pharmacology / Q000627:therapeutic use*; D006801:Humans; D007938:Leukemia / Q000188:drug therapy* / Q000378:metabolism; D008297:Male; D009404:Nephrotic Syndrome / Q000188:drug therapy* / Q000378:metabolism; D011627:Puberty; D013268:Stimulation, Chemical; D013737:Testis / Q000378:metabolism*; D013739:Testosterone / Q000652:urine
D006063:Chorionic Gonadotropin; D013739:Testosterone; D003520:Cyclophosphamide