[Influence of parathyroid hormone and heparin on tooth development in mice homozygous for the microphthalmia mutation].
In mice, homozygous by microphthalmia (mi/mi) gene the disturbance of dental development was due to defects in dental pulp and to the absence of bone resorpion. Administration of heparin or parathyroid hormone stimulated dental eruption in mi/mi mice. Following combined action of heparin and parathyroid hormone the number of erupted teeth was practically the same as after the action of heparin alone. Possibly the level of heparin is insufficient, but secretion of parathyroid hormone is unimpaired in mi/mi mice.
D000818:Animals; D006493:Heparin / Q000494:pharmacology*; D051379:Mice; D008850:Microphthalmos / Q000188:drug therapy / Q000235:genetics*; D009805:Odontogenesis / Q000187:drug effects; D010281:Parathyroid Hormone / Q000494:pharmacology*; D014071:Tooth Abnormalities / Q000209:etiology; D014078:Tooth Eruption / Q000187:drug effects*
D010281:Parathyroid Hormone; D006493:Heparin
Vliianie paratireoidnogo gormona i geparina na razvitie zubov u mysheĭ, gomozigotnykh po mutatsii microphthalmia