[Contraceptive activity of combinations of steroids and antiadrenergic preparations].
Experiments were conducted on mature female rats. Simultaneous administration through a tube for 14 days, daily, of mestranol (0.04 mg/kg) and megestrol acetate (0.8 mg/kg) gave no significant contraceptive effect, whereas the use of steroid preparations in the same doses in combination with antiadrenergic substances--dopegit (100 mg/kg) or pyrroxan (10 mg/kg) prevented pregnancy effectively.
D000818:Animals; D003271:Contraceptive Agents, Female / Q000494:pharmacology*; D004146:Dioxanes / Q000494:pharmacology*; D004147:Dioxins / Q000494:pharmacology*; D004353:Drug Evaluation, Preclinical; D004359:Drug Therapy, Combination; D005260:Female; D008535:Megestrol / Q000494:pharmacology*; D008656:Mestranol / Q000494:pharmacology*; D008750:Methyldopa / Q000494:pharmacology*; D011247:Pregnancy; D011759:Pyrrolidines / Q000494:pharmacology; D051381:Rats
D003271:Contraceptive Agents, Female; D004146:Dioxanes; D004147:Dioxins; D011759:Pyrrolidines; D008750:Methyldopa; D008656:Mestranol; D008535:Megestrol
O kontratseptivnoĭ aktivnosti sochentaniĭ steroidnykh i antiadrenergicheskikh preparatov