The effect of noxytiolin in experimental peritonitis.
The evidence for the value of noxytiolin (Noxyflex) in peritonitis is contradictory. In a controlled trial of the effect of noxytiolin in pertonitis in rabbits we have found a significant increase in mortality in the trial group compared with a control group, but no significant difference when a dose equivalent to the recommended human dose is used. The postoperative course is adversely affected in the animals receiving noxytiolin.
D000818:Animals; D009677:Noxythiolin / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D010538:Peritonitis / Q000188:drug therapy*; D011817:Rabbits; D013890:Thiourea / Q000031:analogs & derivatives*
D009677:Noxythiolin; D013890:Thiourea