[The properdin titer in women with labor pathology or gynecological disease and the role of this titer in the prognosis].
Properdin-titers of 1350 women were determined to appreciate the properdin-system in obstetrics and gynaecology. At first the means of properdin of healthy pregnant women (separated to three months-terms) and blood donors were determined. Then the quantities of properdin-system of pregnant women, parturients and lying-in women with pathologic processes and extragenital diseases and of patients with gynaecologic diseases were explored. The properdin-titer of healthy women at the end of gestation was increased. With a level of 99,6 units the central properdin-titer of these women was lower than the central titer of female blood donors with a level of 109,6 units. During delivery the properdintiter of healthy women decreased, in the period after childbirth it increased again. The determination of properdin of pregnant women, parturients and lying-in women with rheumatic heart defects and gestosises is of great importance. The properdin-titer was low in cases with severe heart diseases and a long issue. The prognostic significance of the test demonstrates the good event of pregnancies, deliveries, post partum periods and late gestosises of women with high properdin-titer regardless of the severity of the pathological state. In comparison with the titer of healthy lying-in women attention is to be directed to the slow rising of the properdin-titer of lying-in women after complicated pregnancy. In cases of gynaecological diseases the determination of the properdin-titer has three purposes: The control of the severity of the disease, the control of the effectiveness of the therapy and the evidence of the prognosis. This is especially conclusive for inflammatory diseases of the genital organs. The worse the turn of the inflammatory disease, the more was the decrease of the properdin-titer and the slower was the activation of the properdin-system in the organism. In cases of septic diseases the importance of the properdin level for prognostic assertion must also be pointed out. The remaining low properdin-titer and its further decrease is characteristical for most of these patients, who show in spite of modern therapeutical methods a long turn of the disease, new septic metastases and a considerable reduction of the general state of health.
D000024:Abortion, Illegal; D000328:Adult; D001782:Blood Donors; D005260:Female; D006801:Humans; D006973:Hypertension / Q000276:immunology; D007747:Labor Stage, First; D007748:Labor Stage, Second; D007749:Labor Stage, Third; D007744:Obstetric Labor Complications / Q000276:immunology; D000292:Pelvic Inflammatory Disease / Q000276:immunology; D010538:Peritonitis / Q000276:immunology; D011247:Pregnancy; D011379:Prognosis; D011414:Properdin / Q000032:analysis*; D012214:Rheumatic Heart Disease / Q000276:immunology*
D011414:Properdin
Die Properdin-Kennziffer bei Frauen mit einer Entbindungspathologie oder gynäkologischen Pathologie und die Rolle dieser Kennziffer in der Erkrankungsprognose