[Blood-liquor distribution of ampicillin in children with meningitis and without (author's transl)].
The distribution of ampicillin between blood and cerebrospinal fluid was compared in patients with serous meningitis to that in patients without inflammation of the meningeal membranes. Ampicillin was applied as a continuous intravenous infusion. Samples of blood and cerebrospinal fluid were taken after 1,2,4 or 12 h for the determination of the ampicillin concentrations. In both groups of patients the ratio of concentration in cerebrospinal fluid to concentration in plasma rose between the first and second hour after administration and reached a steady-state value thereafter. This steady-state ratio was 0.025 in patients without meningitis and 0.061 in patients with meningitis. These results are discussed in the context of a pharmacokinetic model which describes the distribution of drugs between blood and cerebrospinal fluid.
D000667:Ampicillin / Q000008:administration & dosage / Q000097:blood* / Q000134:cerebrospinal fluid; D001772:Blood Cell Count; D001812:Blood-Brain Barrier; D002648:Child; D002675:Child, Preschool; D004058:Diffusion; D006801:Humans; D007263:Infusions, Parenteral; D007700:Kinetics; D008581:Meningitis / Q000097:blood* / Q000134:cerebrospinal fluid; D008954:Models, Biological; D013997:Time Factors
D000667:Ampicillin
Die Blut-Liquor-Verteilung von Ampicillin bei Kindern mit und ohne Meningitis