Antagonistic effect of cyproheptadine on neuroleptic-induced catalepsy.
The influence of cyproheptadine on the neuroleptic-catalepsy in rats was studied. Cyproheptadine antagonized dose-dependently the catalepsy induced by spiroperidol, pimozide, fluphenazine and reserpine. The anticataleptic effect of two antiparkinsonian drugs, L-DOPA or amantadine was potentiated by cyproheptadine.
D000547:Amantadine / Q000494:pharmacology; D000818:Animals; D002375:Catalepsy / Q000139:chemically induced / Q000503:physiopathology*; D003533:Cyproheptadine / Q000494:pharmacology*; D004295:Dihydroxyphenylalanine / Q000494:pharmacology; D004357:Drug Synergism; D005476:Fluphenazine / Q000037:antagonists & inhibitors; D006801:Humans; D010868:Pimozide / Q000037:antagonists & inhibitors; D051381:Rats; D012110:Reserpine / Q000037:antagonists & inhibitors; D013134:Spiperone / Q000494:pharmacology; D013997:Time Factors; D014149:Tranquilizing Agents / Q000494:pharmacology*
D014149:Tranquilizing Agents; D010868:Pimozide; D003533:Cyproheptadine; D013134:Spiperone; D004295:Dihydroxyphenylalanine; D012110:Reserpine; D000547:Amantadine; D005476:Fluphenazine