False rise of starch-iodine determined amylase values caused by heparin treatment during haemodialysis.
A false rise in the levels of serum amylase as determined by a starch-iodine method was observed in patients undergoing haemodialysis and after treatment with heparin. In in vitro experiments, neither dialysis of serum nor addition of heparin produced a corresponding increase. The results showed that lipoproteins, altered by heparin-induced lipoprotein lipase, may have a considerable influence by interacting with starch and thereby partly preventing the formation of starch-iodine complexes. Amyloclastic methods that employ the starch-iodine reaction for determining amylase are therefore not to be used on patients treated with heparin.
D000681:Amylases / Q000097:blood*; D005189:False Positive Reactions; D005230:Fatty Acids, Nonesterified / Q000097:blood; D006493:Heparin / Q000627:therapeutic use*; D006801:Humans; D007455:Iodine; D007676:Kidney Failure, Chronic / Q000628:therapy; D008074:Lipoproteins / Q000097:blood; D006435:Renal Dialysis; D013213:Starch; D014280:Triglycerides / Q000097:blood
D005230:Fatty Acids, Nonesterified; D008074:Lipoproteins; D014280:Triglycerides; D013213:Starch; D006493:Heparin; D007455:Iodine; D000681:Amylases