Biological properties of a new non-steroidal anti-inflammatory drug: etoclofene.
Etoclofene, the ethoxy methyl ester of N-(2,6-dichloro-m-tolyl)anthranilic acid, showed potent anti-inflammatory, anti-pyretic and peripheral analgesic activity in several experimental models of inflammation. There was no evidence of adrenal dependence or corticoid-like effects at effective and non-toxic dose levels. Etoclofene showed a low level of toxicity and was well tolerated in animals.
D000700:Analgesics / Q000627:therapeutic use; D000818:Animals; D000893:Anti-Inflammatory Agents; D001168:Arthritis / Q000188:drug therapy; D001241:Aspirin / Q000627:therapeutic use; D004487:Edema / Q000188:drug therapy; D005260:Female; D006168:Guinea Pigs; D007213:Indomethacin / Q000627:therapeutic use; D007928:Lethal Dose 50; D008297:Male; D008469:Meclofenamic Acid / Q000627:therapeutic use; D008528:Mefenamic Acid / Q000627:therapeutic use; D051379:Mice; D010653:Phenylbutazone / Q000627:therapeutic use; D051381:Rats; D062367:ortho-Aminobenzoates / Q000627:therapeutic use* / Q000633:toxicity
D000700:Analgesics; D000893:Anti-Inflammatory Agents; D062367:ortho-Aminobenzoates; D008528:Mefenamic Acid; D008469:Meclofenamic Acid; D010653:Phenylbutazone; D001241:Aspirin; D007213:Indomethacin