[The mechanism of insulin secretion following oral glucose administration. 4. Inhibition of the early reflectoric phase of plasma insulin increase through atropine].
In the first phase after on oral glucose load or after sham-feeding of glucose in conscious intact or on the oesophagus fistulated dogs respectively, the peripheral venous plasma insulin concentration increases independently of any blood glucose alteration. After previous intravenous atropin injection, this reflectoric insulin secretion cannot be observed. The N. vagus is involved in the afferent and/or efferent side of the reinforcing mechanism of insulin secretion basing on the entero-insular axis. Additionally the enteral glucose absorption is inhibited.
D000818:Animals; D001285:Atropine / Q000008:administration & dosage / Q000494:pharmacology*; D001786:Blood Glucose / Q000378:metabolism; D003864:Depression, Chemical; D004285:Dogs; D004937:Esophageal Fistula / Q000378:metabolism; D005230:Fatty Acids, Nonesterified / Q000097:blood; D005260:Female; D005947:Glucose / Q000008:administration & dosage / Q000378:metabolism / Q000494:pharmacology*; D007328:Insulin / Q000097:blood / Q000378:metabolism*; D000078790:Insulin Secretion; D007408:Intestinal Absorption; D008297:Male
D001786:Blood Glucose; D005230:Fatty Acids, Nonesterified; D007328:Insulin; D001285:Atropine; D005947:Glucose
Der Mechanismus der Insulinsekretion nach oraler Glukoseverabfolgung. IV. Verhinderung der reflektorischen Frühphase des Plasmainsulin-Anstieges durch Atropin