Potentiation of the hepatotoxic responses to chemicals in alloxan-diabetic rats.
Alloxan diabetes enhances the hepatotoxic response of male rats to chloroform and 1, 1, 2-trichloroethane, but not to trichloroethylene nor 1, 1, 1-trichloroethane. Insulin treatment partially protects the animals against the alloxan-induced enhancement of chloroform hepatotoxicity. Alloxan diabetes also enhances the hepatotoxic response to galactosamine but not to beryllium nor alpha-naphthylisothiocyanate.
D015058:1-Naphthylisothiocyanate / Q000494:pharmacology; D000410:Alanine Transaminase / Q000097:blood; D000818:Animals; D001663:Bilirubin / Q000097:blood; D001786:Blood Glucose; D056486:Chemical and Drug Induced Liver Injury / Q000503:physiopathology; D002725:Chloroform / Q000633:toxicity; D003921:Diabetes Mellitus, Experimental / Q000503:physiopathology*; D004980:Ethane / Q000031:analogs & derivatives / Q000633:toxicity; D005688:Galactosamine / Q000494:pharmacology; D006843:Hydrocarbons, Chlorinated / Q000633:toxicity; D007328:Insulin / Q000494:pharmacology; D007521:Isocitrate Dehydrogenase / Q000097:blood; D008099:Liver / Q000032:analysis / Q000503:physiopathology*; D008297:Male; D051381:Rats; D014241:Trichloroethylene / Q000633:toxicity; D014280:Triglycerides / Q000032:analysis
D001786:Blood Glucose; D006843:Hydrocarbons, Chlorinated; D007328:Insulin; D014280:Triglycerides; D014241:Trichloroethylene; D015058:1-Naphthylisothiocyanate; D005688:Galactosamine; D002725:Chloroform; D007521:Isocitrate Dehydrogenase; D000410:Alanine Transaminase; D004980:Ethane; D001663:Bilirubin