Effect of antimycin A on sensivitivy of fertilized sea urchin egg cells to embryotoxic analogs of serotonin.
Antimycin A blocks cleavage divisions in concentrations 1-10-15-1-10-14 g/ml (experiments on Arbacia lixula) or 1-10-11-1-10-9 g/ml (experiments on sea urchins of the genus Strongylocentrotus). Subthreshold and threshold concentrations of this antibiotic do not affect the sensitivity of fertilized Strongylocentrotus intermedius to 1-benzyl-2, 5-dimethylserotonin, but increase their sensitivity to 5-butyltryptamine by a factor of 3-5. These data provide the basis for a discussion of the possible nature of the reception of serotonin and other low-molecular-weight regulators of early embryogenesis.
D000818:Animals; D000968:Antimycin A / Q000494:pharmacology*; D002455:Cell Division / Q000187:drug effects; D004347:Drug Interactions; D005260:Female; D005306:Fertilization; D006128:Growth; D008928:Mitochondria / Q000187:drug effects; D010063:Ovum / Q000187:drug effects* / Q000502:physiology / Q000648:ultrastructure; D011955:Receptors, Drug; D012617:Sea Urchins / Q000187:drug effects / Q000196:embryology*; D012701:Serotonin / Q000031:analogs & derivatives* / Q000494:pharmacology
D011955:Receptors, Drug; D012701:Serotonin; D000968:Antimycin A