Intestinal tumors of rats by gastric or intestinal administration of cycad extract and cycasin.
Sprague-Dawley rats were given gastric intubation of cycad extract (group 1), rectal infusion of cycasin (group 2), or rectal indusion of cycad extract after external colostomy at 1/3 proximal portion of the large intestine (group 3). In group 1, intestinal tumors developed in any portion of the intestinal tract ranging from the duodenum to the rectum. In group 2, tumors developed in mucosa of the large intestine. In group 3, however, tumors arose from both sites of intestinal mucosa which were in contact and not in contact directly with the cycad extract infused. Possible hypothesis for intestinal tumor development by cycad extract and cycasin was presented.
D000230:Adenocarcinoma / Q000139:chemically induced* / Q000473:pathology; D000236:Adenoma / Q000139:chemically induced* / Q000473:pathology; D000818:Animals; D001391:Azo Compounds / Q000008:administration & dosage*; D002273:Carcinogens / Q000008:administration & dosage*; D003125:Colostomy; D003492:Cycasin / Q000008:administration & dosage*; D005260:Female; D007263:Infusions, Parenteral; D007414:Intestinal Neoplasms / Q000139:chemically induced* / Q000473:pathology; D007420:Intestine, Large / Q000473:pathology / Q000601:surgery; D007421:Intestine, Small / Q000473:pathology; D007441:Intubation, Gastrointestinal; D008297:Male; D009374:Neoplasms, Experimental; D010936:Plant Extracts / Q000008:administration & dosage*; D010947:Plants, Toxic / Q000032:analysis; D051381:Rats; D012007:Rectum
D001391:Azo Compounds; D002273:Carcinogens; D010936:Plant Extracts; D003492:Cycasin