Candida endocarditis treated with a combination of antifungal chemotherapy and aortic valve replacement.
A case of Candida albicans endocarditis is described in which treatment with 5-fluorocytosine was started after aortic valve replacement, but relapse followed discontinuance of treatment. At a second operation the aortic valve was replaced under 5-fluorocytosine cover and treatment was continued with both 5-fluorocytosine and amphotericin-B. No resistance to 5-fluorocytosine developed, and the candida infection was eradicated. The patient is well 22 months after his operation.
D000666:Amphotericin B / Q000627:therapeutic use; D001021:Aortic Valve / Q000601:surgery; D002177:Candidiasis; D004696:Endocarditis / Q000188:drug therapy / Q000209:etiology* / Q000601:surgery; D005437:Flucytosine / Q000627:therapeutic use; D006350:Heart Valve Prosthesis; D006801:Humans; D008297:Male; D008875:Middle Aged
D000666:Amphotericin B; D005437:Flucytosine