Neuroleptic action of clozapine injected into various brain areas in rats.
Bilateral microinjections of clozapine into the corpus striatum of rats antagonize amphetamine-induced stereotypy, and develops catalepsy. These two neuroleptic effects are not seen after subcutaneous or oral administration of clozapine. The effects were a little weaker than those seen after chlorpromazine. No neuroleptic effects were observed, when placebo was injected intrastriatally, nor when clozapine was injected into the hippocampus or the thalamus.
D000661:Amphetamine / Q000037:antagonists & inhibitors / Q000494:pharmacology; D000818:Animals; D001921:Brain / Q000187:drug effects*; D002375:Catalepsy / Q000139:chemically induced; D002540:Cerebral Cortex / Q000187:drug effects; D002746:Chlorpromazine / Q000494:pharmacology; D003024:Clozapine / Q000008:administration & dosage* / Q000494:pharmacology; D003342:Corpus Striatum / Q000187:drug effects; D003984:Dibenzazepines / Q000008:administration & dosage*; D006624:Hippocampus / Q000187:drug effects; D006801:Humans; D007267:Injections; D008297:Male; D051381:Rats; D013239:Stereotyped Behavior / Q000187:drug effects; D013788:Thalamus / Q000187:drug effects; D014149:Tranquilizing Agents
D003984:Dibenzazepines; D014149:Tranquilizing Agents; D000661:Amphetamine; D003024:Clozapine; D002746:Chlorpromazine