[Genetic studies in hypoplastic left heart syndrome (author's transl)].
The families of the 18 patients with hypoplastic left heart syndrome (HLH), who died in the Universitätskinderklinik Erlangen between 1967 and January 1974, have been investigated. There was no consanguinity of the parents. Only one sib has died of a cardiac failure which possibly could have been HLH. Therefore it could be excluded that HLH is an autosomal-recessive disorder. The overall incidence of cardiac failure in the sibs of patients was 3. Most of the patients with HLH have been born in June-August and December-January. Environmental factors seem to be of importance in the genesis of HLH. Our results suggest multifactorial inheritance of the hypoplastic left heart syndrome.
D000015:Abnormalities, Multiple / Q000235:genetics; D000367:Age Factors; D005260:Female; D006330:Heart Defects, Congenital / Q000235:genetics*; D006801:Humans; D007223:Infant; D008297:Male; D011247:Pregnancy; D011248:Pregnancy Complications; D012621:Seasons; D012737:Sex Factors; D013577:Syndrome
Beitrag zur Genetik des Syndroms des hypoplastischen Linksherzens