Multivariate analysis in the pharmacological evaluation of a saluretic compound.
The pharmacological evaluation of the diuretic activity of a compound -- performed measuring the urinary volume and determining its electrolyte content -- may be usefully integrated by a multivariate analysis, in order to: express a general evaluation for each animal in terms of positive or negative response; evaluate the false positive responses of the control group animals and the negative responses in the treated animals on the basis of the general response. An example of application relating to a well-known saluretic, 4-chloro-N-(2-furfuryl)-5-sulfamoyl-anthranilic acid (furosemide), is reported.
D000704:Analysis of Variance; D000818:Animals; D002712:Chlorides / Q000652:urine; D004231:Diuresis / Q000187:drug effects*; D004341:Drug Evaluation / Q000379:methods*; D005189:False Positive Reactions; D005665:Furosemide / Q000494:pharmacology*; D009318:Natriuresis / Q000187:drug effects; D011188:Potassium / Q000652:urine; D051381:Rats; D012964:Sodium / Q000652:urine; D013223:Statistics as Topic / Q000379:methods
D002712:Chlorides; D005665:Furosemide; D012964:Sodium; D011188:Potassium