Induced adrenal and ovarian enlargement in nursing mothers by a single mug injection to their pups of a 3beta-hydroxy-delta5-steroid oxidoreductase inhibitor.
Isoxazole-14C, a potent inhibitor of 3beta-hydroxy-delta5-steroid oxidoreductase, injected into nursing pups is naturally transferred to their mother where it is retained, for at least a month, in ng quantities in the adrenals and ovaries and results in adrenal, ovarian, preputial and pituitary enlargement.
D000311:Adrenal Glands / Q000201:enzymology* / Q000473:pathology; D000818:Animals; D000831:Animals, Newborn / Q000378:metabolism; D005260:Female; D006913:Hydroxysteroid Dehydrogenases / Q000037:antagonists & inhibitors*; D007555:Isoxazoles / Q000494:pharmacology*; D007774:Lactation / Q000187:drug effects; D010053:Ovary / Q000201:enzymology* / Q000473:pathology; D010080:Oxazoles / Q000494:pharmacology*; D010902:Pituitary Gland / Q000201:enzymology / Q000473:pathology; D011247:Pregnancy; D011375:Progesterone Reductase / Q000037:antagonists & inhibitors*; D051381:Rats
D007555:Isoxazoles; D010080:Oxazoles; D006913:Hydroxysteroid Dehydrogenases; D011375:Progesterone Reductase