A lipid inhibitor of dengue virus in human colostrum and milk; with a note on the absence of anti-dengue secretory antibody.
Neutralizing activity against dengue virus types 1--4 was observed in milk samples from 5 non-immune and 29 dengue immune women. Anti-dengue activity in milk and colostrum was found only in the lipid component. The inhibitory activity is directed against the virus and not cell surfaces. When immunoglobulin types IgM,IgA, IgG were isolated from colostrum from dengue immune women, no antibody activity was found. Anti-dengue activity in human milk did not decrease over a period of ten months after delivery.
D000818:Animals; D000914:Antibodies, Viral / Q000032:analysis; D000998:Antiviral Agents; D002460:Cell Line; D002850:Chromatography, Gel; D003126:Colostrum / Q000276:immunology*; D003715:Dengue / Q000276:immunology; D003716:Dengue Virus / Q000254:growth & development / Q000276:immunology*; D005260:Female; D006385:Hemagglutination Inhibition Tests; D006801:Humans; D007070:Immunoglobulin A / Q000032:analysis; D007074:Immunoglobulin G / Q000032:analysis; D007075:Immunoglobulin M / Q000032:analysis; D007668:Kidney; D008055:Lipids / Q000276:immunology*; D008251:Macaca; D008895:Milk, Human / Q000276:immunology*; D009500:Neutralization Tests; D011247:Pregnancy; D014744:Vietnam; D010948:Viral Plaque Assay; D014779:Virus Replication
D000914:Antibodies, Viral; D000998:Antiviral Agents; D007070:Immunoglobulin A; D007074:Immunoglobulin G; D007075:Immunoglobulin M; D008055:Lipids