Investigations on the relations between the biochemical changes in the brain and behaviour of irradiated rats.
The behaviour of irradiated rats and biochemical changes in the brain tissue were investigated in the early period after whole-body irradiation with the dose of 800 R. It was found that after exposition to X-ray psychomotoric activity undergoes phasic modifications. Within the first day the behavioural activation was stated, which was accompanied by the increase of hydroproteolytic and MAO, activity in the brain. Simultaneously a decrease of serotonin and noradrenalin content in the brain stem was found in irradiated rats. On the second and third day of postirradiation syndrome the behavioural inhibition was observed.
D000135:Acid Phosphatase / Q000032:analysis; D000818:Animals; D001522:Behavior, Animal / Q000528:radiation effects*; D001921:Brain / Q000201:enzymology; D001923:Brain Chemistry / Q000528:radiation effects*; D008297:Male; D008995:Monoamine Oxidase / Q000032:analysis; D008996:Monoamine Oxidase Inhibitors / Q000494:pharmacology; D009043:Motor Activity / Q000187:drug effects / Q000528:radiation effects; D009526:Nialamide / Q000494:pharmacology; D009638:Norepinephrine / Q000032:analysis / Q000494:pharmacology; D010447:Peptide Hydrolases / Q000032:analysis; D011830:Radiation Effects; D051381:Rats; D012701:Serotonin / Q000032:analysis / Q000494:pharmacology
D008996:Monoamine Oxidase Inhibitors; D012701:Serotonin; D008995:Monoamine Oxidase; D000135:Acid Phosphatase; D010447:Peptide Hydrolases; D009526:Nialamide; D009638:Norepinephrine