[Influence of whole-body irradiation with 60Co on poly I:C induced interferon in mice (author's transl)].
After whole-body irradiation with 200, 900 und 1500 R on mice Poly I:C induced serum interferon was decreased. 24 and 48 hours p.r. the interferon-synthesis in the three irradiated groups was considerably reduced. Increasing interferon-titer-yet lower than those of not irradiated controls - were found after Poly I:C application 3, 4 and 5 days p.r. in the groups irradiated with 200 and 900 R. In these two groups a relationship between irradiation-dose and interferon-synthesis was recognized.
D000818:Animals; D003037:Cobalt Radioisotopes; D004307:Dose-Response Relationship, Radiation; D007369:Interferon Inducers / Q000528:radiation effects*; D007372:Interferons / Q000096:biosynthesis / Q000528:radiation effects*; D051379:Mice; D011070:Poly I-C / Q000494:pharmacology*; D011830:Radiation Effects; D013997:Time Factors; D010948:Viral Plaque Assay
D003037:Cobalt Radioisotopes; D007369:Interferon Inducers; D007372:Interferons; D011070:Poly I-C
Einfluss von Ganzköperbestrahlung mit 60Co auf die interferoninduktion durch Poly I:C bei Mäusen