Effect of diazinon in male rats. Histopathological and biochemical studies.
Mild structural and functional changes were observed in liver and testes of rats after a single intraperitoneal administration of diazinon (21.6 mg/kg). Kidney, however, showed no pathological lesion. Attempts are made to correlate the pathological changes in these organs with the activity of succinic dehydrogenase, adenosine triphosphatase and alkaline phosphatase.
D000255:Adenosine Triphosphate / Q000378:metabolism; D000469:Alkaline Phosphatase / Q000378:metabolism; D000818:Animals; D003976:Diazinon / Q000008:administration & dosage / Q000494:pharmacology*; D007274:Injections, Intraperitoneal; D007306:Insecticides / Q000494:pharmacology*; D007668:Kidney / Q000187:drug effects* / Q000201:enzymology; D008099:Liver / Q000187:drug effects* / Q000201:enzymology; D008297:Male; D051381:Rats; D013385:Succinate Dehydrogenase / Q000378:metabolism; D013737:Testis / Q000187:drug effects* / Q000201:enzymology
D007306:Insecticides; D000255:Adenosine Triphosphate; D013385:Succinate Dehydrogenase; D000469:Alkaline Phosphatase; D003976:Diazinon