RNA synthesis in liver nuclei of young rats fed varying amounts of vitamin A.
Twenty five days old male rats were feed 5000, 20000 and 40000 I.U. of vitamin A for two days and its effects studied on RNA contents and its synthesis from orotic acid-6(-14)C in liver and its nuclear and mitochondrial fractions. RNA contents and its synthesis from orotic acid-6(-14)C in liver, its nuclear and mitochondrial fractions was not affected in rats 5000 I.U. of vitamin A, but these were reduced in rats fed 20000 and 40000 I.U. of vitamin A. The turnover rate of nuclear RNA was significantly greater in rats fed 5000 I.U. of vitamin A as compared to the controls.
D000818:Animals; D002467:Cell Nucleus / Q000187:drug effects / Q000378:metabolism; D003864:Depression, Chemical; D008099:Liver / Q000187:drug effects* / Q000378:metabolism / Q000648:ultrastructure; D008297:Male; D008930:Mitochondria, Liver / Q000187:drug effects / Q000378:metabolism; D009963:Orotic Acid / Q000378:metabolism; D012313:RNA / Q000096:biosynthesis*; D051381:Rats; D013268:Stimulation, Chemical; D014801:Vitamin A / Q000008:administration & dosage / Q000494:pharmacology*
D014801:Vitamin A; D009963:Orotic Acid; D012313:RNA