Growth hormone catecholamines in affective disease.
The authors studied growth hormone (GH) release after insulin-induced hypoglycemia (HI) in relation to urinary MHPG, the major metabolite of central norepinephrine. There was a significant linear correlation of urinary MHPG levels and GH peaks after HI in unipolar depressed patients and in manic patients; however, GH peaks in manic patients shifted downward on the GH axis in comparison to the unipolar depressive patients. The authors suggest that such shifts in the GH response may occur as a result of abnormalities of other neurotransmitter systems also known to facilitate GH release.
D000328:Adult; D001714:Bipolar Disorder / Q000378:metabolism*; D001786:Blood Glucose / Q000378:metabolism; D003863:Depression / Q000378:metabolism*; D003864:Depression, Chemical; D005260:Female; D006018:Glycols / Q000652:urine*; D013006:Growth Hormone / Q000097:blood*; D006801:Humans; D007003:Hypoglycemia / Q000378:metabolism; D007328:Insulin / Q000494:pharmacology; D008297:Male; D008734:Methoxyhydroxyphenylglycol / Q000652:urine*; D008875:Middle Aged
D001786:Blood Glucose; D006018:Glycols; D007328:Insulin; D008734:Methoxyhydroxyphenylglycol; D013006:Growth Hormone