Comparative bioassay of prostaglandin E2 and its three pulmonary metabolites.
The relative potencies of prostaglandin E2 and its metabolites 15-keto PGE2, 13,14-dihydro-15-keto-PGE2 and 13,14,dihydro-PGE2 were investigated on isolated smooth muscle preparations. These were rat stomach strip, colon and uterus, chick rectum, guinea-pig ileum, trachea and pulmonary artery and rabbit aorta and pulmonary artery. 15-keto PGE2 was equiactive or 1-1.8 times more potent than prostaglandin E2 in relaxing guinea-pig trachea but otherwise the three metabolites were less active than prostaglandin E2 on all preparations.
D000818:Animals; D001011:Aorta / Q000187:drug effects; D002645:Chickens; D003106:Colon / Q000187:drug effects; D006168:Guinea Pigs; D066298:In Vitro Techniques; D008168:Lung / Q000378:metabolism*; D009119:Muscle Contraction / Q000187:drug effects; D009130:Muscle, Smooth / Q000187:drug effects; D011458:Prostaglandins E / Q000032:analysis* / Q000378:metabolism / Q000494:pharmacology; D011651:Pulmonary Artery / Q000187:drug effects; D051381:Rats; D012007:Rectum / Q000187:drug effects; D013270:Stomach / Q000187:drug effects
D011458:Prostaglandins E