Adrenal function and the effect of a high-fat diet on C57BL/6J and C57BL/6J-ob/ob mice.
In C57BL/6J mice and the ob/+ and ob/ob mutants total plasma corticosterone levels were found to be statistically different. In C57BL/6J mice the level was 1.9 +/- 0.2 mug/100 ml plasma, in ob/+ mice 8.6 +/- 1.6 mug/100 ml and in ob/ob mice 13.7 +/- 1.5 mug/100 ml. The percentage of protein-bound corticosterone as well as the free endogenous corticosterone levels were also different. Feeding a high-fat diet to young C57BL/6J and C57BL/6J-ob/ob mice for a period of 4 weeks had no effect upon blood glucose, plasma insulin and plasma corticosterone levels. The significantly higher increase in body weight of the high-fat diet groups of both lines of mice was mainly due to fat cell hypertrophy.
D000273:Adipose Tissue / Q000033:anatomy & histology / Q000187:drug effects; D000311:Adrenal Glands / Q000187:drug effects / Q000502:physiology*; D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D001798:Blood Proteins / Q000378:metabolism; D001835:Body Weight; D003345:Corticosterone / Q000097:blood; D004041:Dietary Fats; D007328:Insulin / Q000097:blood; D008055:Lipids / Q000494:pharmacology; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL / Q000378:metabolism*; D008820:Mice, Obese / Q000378:metabolism*
D001786:Blood Glucose; D001798:Blood Proteins; D004041:Dietary Fats; D007328:Insulin; D008055:Lipids; D003345:Corticosterone