Chloramphenicol-resistant Salmonella typhi in Saigon.
Chloramphenicol-resistant Salmonella typhi was detected in Saigon in September 1971. Subsequently, 163 strains of S typhi were isolated, 46 percent of which were resistant to choramphenicol by the agar-disk method. Sixty-two strains were studied by the broth-dilution method; 37 percent had minimal inhibitory concentrations for chloramphenicol greater than 250mug/ml, but all strains were susceptible to 0.4mug/ml of ampicillin and to a disk of a combination of trimethoprim and sulfamethoxazole (Bactrim). Persons infected with chloramphenicol-resistant strains of S typhi responded poorly to chloramphenicol alone, but ampicillin or the combination drug was effective.
D000328:Adult; D002701:Chloramphenicol / Q000494:pharmacology*; D004352:Drug Resistance, Microbial; D004359:Drug Therapy, Combination; D006801:Humans; D008297:Male; D008826:Microbial Sensitivity Tests / Q000379:methods; D012480:Salmonella Infections / Q000188:drug therapy; D012485:Salmonella typhi / Q000187:drug effects*; D013420:Sulfamethoxazole / Q000494:pharmacology* / Q000627:therapeutic use; D014295:Trimethoprim / Q000494:pharmacology* / Q000627:therapeutic use; D014744:Vietnam
D002701:Chloramphenicol; D014295:Trimethoprim; D013420:Sulfamethoxazole