Sulphonylureas and insulin resistance.
This is a case report of a diabetic who required 750-1000 units of insulin per day when gangrene of the leg developed, whereas previously he had needed no insulin. After amputation of the leg, the patient remained asymptomatic for 9 weeks without insulin. This was clearly related to an increased concentration of circulating antibody-bound insulin. Despite healing at the site of amputation, diabetic symptoms and insulin resistance reappeared. Chlorpropamide treatment reduced the insulin requirement to zero, which was unrelated to a change in insulin antibody concentration.
D002747:Chlorpropamide / Q000627:therapeutic use*; D003920:Diabetes Mellitus / Q000188:drug therapy* / Q000276:immunology; D005260:Female; D006801:Humans; D007328:Insulin / Q000008:administration & dosage* / Q000627:therapeutic use; D007330:Insulin Antibodies; D007333:Insulin Resistance; D008875:Middle Aged
D007328:Insulin; D007330:Insulin Antibodies; D002747:Chlorpropamide