Production of respiratory tract tumors in hamsters by benzo(a)pyrene.
Respiratory tumor induction was tested for the tumorigenic activity of benzo[a]pyrene alone. A group of 32 male and 28 female Syrian golden hamsters were given weekly intratracheal instillation of 1 mg of benzo[a]pyrene suspended in isotonic saline, for 30 weeks. Squamous cell carcinoma, adenocarcinoma, anaplastic carcinoma, adenoma, papilloma, and polyps were induced in the respiratory tract of hamsters. Tumor incidences were 42.3% in males and 57.7% in females. Respiratory carcinomas were inducible in hamsters by simple instillation of a low dose of benzo[a]pyrene without using a surface-active agent or carrier-dust. These findings may be useful as a standard data for cocarcinogenesis studies when using other modality combined with benzo[a]pyrene in experimental studies.
D000230:Adenocarcinoma / Q000139:chemically induced; D000818:Animals; D001580:Benzopyrenes; D002294:Carcinoma, Squamous Cell / Q000139:chemically induced; D006224:Cricetinae; D005260:Female; D008297:Male; D010212:Papilloma / Q000139:chemically induced; D011127:Polyps / Q000139:chemically induced; D012142:Respiratory Tract Neoplasms / Q000139:chemically induced*
D001580:Benzopyrenes