Percutaneous absorption of drugs. IV. Percutaneous absorption of drugs from oily vehicles.
The percutaneous absorption and retention of salicylic acid and carbinoxamine from four oily vehicles (liquid paraffin, oleic acid, hexadecyl alcohol, and isopropyl myristate) were studied by employing a recirculation apparatus. The absorption followed first-order kinetics, with the exception of the initial period. The vehicle that had a strong affinity to the drug showed a poor drug-releasing effect, and poor absorption and retention of drugs by the skin were observed. Higher absorption rate constants were observed for damaged skin than intact skin. The acceleration of absorption because of skin damage, however, was not so great from liquid paraffin as from the aqueous solution. The amount of drugs retained in the damaged skin declined following the initial increase.
D000818:Animals; D005227:Fatty Acids; D005233:Fatty Alcohols; D006168:Guinea Pigs; D006801:Humans; D066298:In Vitro Techniques; D007231:Infant, Newborn; D008297:Male; D009821:Oils; D009829:Oleic Acids; D010232:Paraffin; D014677:Pharmaceutical Vehicles; D012459:Salicylates / Q000378:metabolism; D012869:Skin Absorption; D012995:Solubility; D013997:Time Factors
D005227:Fatty Acids; D005233:Fatty Alcohols; D009821:Oils; D009829:Oleic Acids; D014677:Pharmaceutical Vehicles; D012459:Salicylates; D010232:Paraffin