The interaction of ochratoxin A with some environmental extremes.
Presently, ochratoxin is the most potent mycotoxin studied in chickens. The possibility that ochratoxin can interact with environmental extremes was investigated by incorporating pure ochratoxin A (0, 0.5, 1.0, 2.0, 4.0, and 8.0 mug./g. feed) into the diet of 4 replicates of 10 birds from hatching until 3 weeks of age. There was a significant (P less than 0.05) decrease in the mean survival times of birds exposed to 4 degrees C. and 90% relative humidity at dose levels of 4.0 and 8.0 mug./g. However, birds exposed to 43 degrees C. and 45% relative humidity had a significantly (P less than 0.05) prolonged mean survival time at 8.0 mug./g. Birds given drinking water containing 2% NaCl had a significant (P less than 0.05) decrease in mean survival time at 8.0 mug./g. These data suggest that ochratoxin like aflatoxin can interact with other agents to produce syndromes not attributable to each alone.
D000818:Animals; D002645:Chickens; D003080:Cold Temperature; D004781:Environmental Exposure; D006358:Hot Temperature; D006813:Humidity; D008297:Male; D009793:Ochratoxins / Q000633:toxicity*; D011201:Poultry Diseases / Q000139:chemically induced*; D012965:Sodium Chloride / Q000494:pharmacology
D009793:Ochratoxins; D012965:Sodium Chloride