[Effect of trypsin on the activity of tetracycline, erythromycin and levomycetin].
Trypsin had an antimicrobial effect on Staph. aureus. Increasing of protein in the broth culture of the staphylococci was inhibited in the presence of 50 gamma/ml of trypsin by 42.8%. The activity of tetracycline, erythromycin and levomycetin increased, when they were used in combination with trypsin, the effect of the trypsin combinations with tetracycline or levomycetin was additive, while that of the combination with erythromycin was synergistic.
D001426:Bacterial Proteins / Q000096:biosynthesis; D002701:Chloramphenicol / Q000494:pharmacology*; D003864:Depression, Chemical; D004305:Dose-Response Relationship, Drug; D004357:Drug Synergism; D004917:Erythromycin / Q000494:pharmacology*; D013211:Staphylococcus aureus / Q000187:drug effects; D013752:Tetracycline / Q000494:pharmacology*; D014357:Trypsin / Q000494:pharmacology*
D001426:Bacterial Proteins; D004917:Erythromycin; D002701:Chloramphenicol; D014357:Trypsin; D013752:Tetracycline
Vliianie tripsina na aktivnost' tetratsiklina, éritromitsina i levomitsetina