Snuff-dippers lesion. A ten-year follow-up.
A population of over 15,000 snuff users and tobacco chewers were observe for cytological, histological, and clinical evaluation. The original observation was for 5 1/2 years. The same group was observed for an additional 4 1/2 years, bringing the total time to ten years. Of the original group of 1,751 patients showing mucosal change, i was able to follow up 1,550. No patient developed carcinoma or serious mucosal changes. From this ten-year study we concluded that snuff, per  se, or chewing do not act as carcinogens.
D000052:Acanthosis Nigricans / Q000139:chemically induced; D001706:Biopsy; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007642:Keratosis / Q000139:chemically induced; D008297:Male; D008875:Middle Aged; D009059:Mouth Diseases / Q000139:chemically induced* / Q000473:pathology; D009061:Mouth Mucosa / Q000473:pathology; D009062:Mouth Neoplasms / Q000139:chemically induced; D014030:Tobacco, Smokeless