[Experimental study in rats on the renal compatibility of cephalothin and cephalothin-aminoglycoside combinations (author's transl)].
The possible nephrotoxity of cephalothin and the antibiotic combinations cephalotin-gentamicin and cephalothin-tobramycin was investigated in standardized animal experiments. Toxicity parameters were blood-urea concentration, the urinary enzymes GOT, LDH, MDH and the cell excretion rate, supplemented by histological investigations of the kidneys. Compared with other cephalosporine derivates, the antibiotic cephalothin in a toxic threshold-dose of 3000 mg/kg/day proved to be realtively well tolerated by the kidneys. On comparison with the respective monotherapy, the renal tolerance for cephalothin-aminoglycoside combinations was reduced. The clinical value of these findings is discussed.
D000617:Aminoglycosides / Q000009:adverse effects*; D000818:Animals; D001219:Aspartate Aminotransferases / Q000652:urine; D002512:Cephalothin / Q000009:adverse effects*; D004338:Drug Combinations; D005260:Female; D005839:Gentamicins / Q000009:adverse effects; D007668:Kidney / Q000201:enzymology; D007674:Kidney Diseases / Q000139:chemically induced*; D007770:L-Lactate Dehydrogenase / Q000652:urine; D008291:Malate Dehydrogenase / Q000652:urine; D051381:Rats; D014031:Tobramycin / Q000009:adverse effects
D000617:Aminoglycosides; D004338:Drug Combinations; D005839:Gentamicins; D007770:L-Lactate Dehydrogenase; D008291:Malate Dehydrogenase; D001219:Aspartate Aminotransferases; D002512:Cephalothin; D014031:Tobramycin
Tierexperimentelle Studie zur Frage der Nephrotoxizität von Cephalotin und Cephalotin-Aminoglykosid-Kombinationen