Central action of drugs acting on the cholinergic muscarinic receptor. IV. Influence of cholinomimetics and cholinolytics injected into the lateral cerebral ventricle in the rat on concentrations of 5-HT and 5-HIAA.
The influence of cholinomimetics (carbachol--CCh, physostigmine--Pht, pilocarpine--Pil) and cholinolytics (atropine--At, scopolamine--Sc) injected into the lateral ventricle of the brain (ivtr) in rats on metabolism of 5-HT was studied by assaying levels of 5-HT and 5-HIAA. In several comparative experiments cholinomimetics were injected i.p. CCh had no influence on levels of 5-HT and 5-HIAA when injected i.p., but raised levels of 5-HIAA injected ivtr. Pht had no influence on concentrations of both substances by either route of administration. Pil raised levels of 5-HIAA when injected i.p. (and by this route of administration also raised levels of 5-HT) as well as ivtr, Both cholinolytics injected ivtr had no influence on concentrations of 5-HT or 5-HIAA.
D000818:Animals; D001285:Atropine / Q000494:pharmacology; D001923:Brain Chemistry / Q000187:drug effects*; D002217:Carbachol / Q000494:pharmacology; D005470:Fluorometry; D006897:Hydroxyindoleacetic Acid / Q000032:analysis*; D008297:Male; D010276:Parasympatholytics / Q000494:pharmacology*; D010277:Parasympathomimetics / Q000494:pharmacology*; D010830:Physostigmine / Q000494:pharmacology; D010862:Pilocarpine / Q000494:pharmacology; D051381:Rats; D011950:Receptors, Cholinergic; D012601:Scopolamine / Q000494:pharmacology; D012701:Serotonin / Q000032:analysis*
D010276:Parasympatholytics; D010277:Parasympathomimetics; D011950:Receptors, Cholinergic; D010862:Pilocarpine; D012701:Serotonin; D006897:Hydroxyindoleacetic Acid; D001285:Atropine; D002217:Carbachol; D010830:Physostigmine; D012601:Scopolamine