A new rapid differentiating solubility test for hemoglobin S.
A new test for sickling hemoglobin, SickleQuikTM, has been developed which has definitive advantages over existing turbidity tests. This test utilizes a biphasic liquid reagent system provided in individualized, ready-to-use reaction tubes which are stable at room temperature. The test differentiates homozygous from heterozygous S samples in less than eight minutes. Results are based on the color of a layer formed at the organic-aqueous interface and the color of the lower aqueous phase. Of more than 900 samples tested in independent laboratories, no false positive or false negative results occurred.
D000755:Anemia, Sickle Cell / Q000097:blood; D006451:Hemoglobin, Sickle / Q000032:analysis*; D006455:Hemoglobins, Abnormal / Q000032:analysis*; D006579:Heterozygote; D006720:Homozygote; D006801:Humans; D008722:Methods; D012995:Solubility; D013789:Thalassemia / Q000097:blood
D006451:Hemoglobin, Sickle; D006455:Hemoglobins, Abnormal