IgE, IgG and patient-self tests during slow hyposensitization to grass pollen.
Twenty-two patients with severe hay fever unrelieved by antihistamines in previous years were slowly hyposensitized with alum-precipitated pyridine grass pollen extracts. Their responses were objectively assessed as very good (55%), good (18%) or improved (23%). Two mechanisms were detected: (i) an increase in serum blocking activity in 59% and (ii) the prevention in 59% of the serum IgE elevation expected in the pollen season.
D000293:Adolescent; D000328:Adult; D000485:Allergens / Q000008:administration & dosage; D000906:Antibodies; D001667:Binding, Competitive; D002648:Child; D003888:Desensitization, Immunologic; D005260:Female; D006801:Humans; D007073:Immunoglobulin E / Q000032:analysis*; D007074:Immunoglobulin G / Q000032:analysis*; D008297:Male; D008875:Middle Aged; D006109:Poaceae / Q000276:immunology*; D011058:Pollen; D011863:Radioimmunoassay; D006255:Rhinitis, Allergic, Seasonal / Q000628:therapy; D012882:Skin Tests; D013997:Time Factors
D000485:Allergens; D000906:Antibodies; D007074:Immunoglobulin G; D007073:Immunoglobulin E