A new antibiotic, fumaramidmycin I. Production, biological properties and characterization of producer strain.
A new antibiotic, fumaramidmycin, has been isolated from a streptomycete NR-7GG1 which was characterized and named Streptomyces kurssanovii. The strain produced the antibiotic only when grown on agar plates but not in the submerged culture broth, where the contact with the vegetative mycelia appears to cause the inactivation of the antibiotic. The antibiotic shows an antimicrobial activity against both Gram-positive and Gram-negative bacteria.
D000818:Animals; D000900:Anti-Bacterial Agents / Q000494:pharmacology; D003470:Culture Media; D005650:Fumarates / Q000378:metabolism; D007928:Lethal Dose 50; D051379:Mice; D008826:Microbial Sensitivity Tests; D010648:Phenylacetates / Q000378:metabolism; D013302:Streptomyces / Q000254:growth & development / Q000378:metabolism*; D013997:Time Factors
D000900:Anti-Bacterial Agents; D003470:Culture Media; D005650:Fumarates; D010648:Phenylacetates