Effects of penfluridol and other drugs on apomorphine-induced stereotyped behavior in monkeys.
The effects of some drugs on apomorphine-induced stereotyped behavior were studied in male cynomolgus monkeys. Apomorphine produced the dose-dependent stereotyped behavior characterized mainly by continuous licking and biting, and repetitive movements of the hands, head and body in the monkeys. Penfluridol as well as haloperidol showed a clear antagonistic effect on the apomorphine-induced stereotyped behavior, while chlorpromazine was less antagonistic than haloperidol. The antagonistic effect of penfluridol lasted longer than that of haloperidol. Reserpine did not inhibit the apomorphine-induced stereotyped behavior though the drug elicited markedly the behavioral depression and alpha-methyl-p-tyrosine also did not block the stereotyped behavior. Nialamide did not depress the apomorphine-induced stereotyped behavior. In provoking the stereotyped behavior in monkeys, apomorphine probably acts directly on dopamine receptors in the extrapyramidal system, and penfluridol is suggested to act as a dopamine receptor blocker with a long action. The results indicate that protection against apomorphine-induced stereotyped behavior in monkeys may be a useful method for evaluating neuroleptic drugs.
D000818:Animals; D001058:Apomorphine / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D001519:Behavior / Q000187:drug effects*; D002746:Chlorpromazine / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D006220:Haloperidol / Q000008:administration & dosage / Q000494:pharmacology; D006801:Humans; D007279:Injections, Subcutaneous; D008252:Macaca fascicularis; D008297:Male; D008781:Methyltyrosines / Q000494:pharmacology; D009526:Nialamide / Q000494:pharmacology; D010395:Penfluridol / Q000494:pharmacology*; D010880:Piperidines / Q000494:pharmacology*; D012110:Reserpine / Q000494:pharmacology; D013239:Stereotyped Behavior / Q000187:drug effects*; D013997:Time Factors
D008781:Methyltyrosines; D010880:Piperidines; D010395:Penfluridol; D012110:Reserpine; D006220:Haloperidol; D001058:Apomorphine; D009526:Nialamide; D002746:Chlorpromazine