Alteration of metastases distribution by vaso-dilating drugs.
The effects of the two vasodilating substances, dihydralazine and the adrenergic alpha-receptor blocker phenoxybenzamine, were studied on the distribution and growth of MCG-L-SS metastases from intravenously injected tumour cells. Dihydralazine increased the total number of metastases in the body and both drugs increased the number in the lungs and the liver. Both drugs also increased the total metastasis volume in the liver. The effects might be secondary to the haemodynamic effects of the drugs, e.g. a changed distribution of the blood flow, more open capillaries and/or a changed hydrostatic capillary pressure.
D000818:Animals; D004078:Dihydralazine / Q000494:pharmacology*; D006830:Hydralazine / Q000031:analogs & derivatives*; D008113:Liver Neoplasms / Q000473:pathology; D008175:Lung Neoplasms / Q000473:pathology; D051379:Mice; D008808:Mice, Inbred CBA; D009362:Neoplasm Metastasis / Q000209:etiology* / Q000473:pathology; D010643:Phenoxybenzamine / Q000494:pharmacology*; D012513:Sarcoma, Experimental / Q000473:pathology; D014666:Vasomotor System / Q000503:physiopathology*
D010643:Phenoxybenzamine; D006830:Hydralazine; D004078:Dihydralazine