Antigen-antibody complexes in or on eosinophils in nasal secretions.
The presence of IgG and ragweed antigen in or on eosinophils in the nasal secretions of ragweed-sensitive patients was investigated by radioautography using specifically purified 125I-labelled antibodies to the above substances. The results indicate a significant (p smaller than 0.001) uptake of antiragweed antibody and anti-IgE antibody by eosinophils. There was no evidence of significant uptake of anti-IgG. From the above findings it was postulated that during the pollination season exposure to ragweed leads to the formation of ragweed-IgE antibody complexes. This is followed by the infiltration of eosinophils into the local tissue and the subsequent phagocytosis of these antigen-antibody complexes by the eosinophils.
D000042:Absorption; D000818:Animals; D000906:Antibodies; D000936:Antigen-Antibody Complex; D001345:Autoradiography; D004804:Eosinophils / Q000276:immunology*; D006041:Goats / Q000276:immunology; D006801:Humans; D007073:Immunoglobulin E / Q000032:analysis; D007140:Immunoglobulin Fab Fragments; D007141:Immunoglobulin Fc Fragments; D007457:Iodine Radioisotopes; D007553:Isotope Labeling; D009093:Mucus / Q000276:immunology*; D009194:Myeloma Proteins; D009297:Nasal Mucosa / Q000378:metabolism; D010587:Phagocytosis; D010936:Plant Extracts; D011058:Pollen; D011817:Rabbits / Q000276:immunology
D000906:Antibodies; D000936:Antigen-Antibody Complex; D007140:Immunoglobulin Fab Fragments; D007141:Immunoglobulin Fc Fragments; D007457:Iodine Radioisotopes; D009194:Myeloma Proteins; D010936:Plant Extracts; D007073:Immunoglobulin E