Metabolism of glutethimide in the human.
Gas chromatographic and gas chromatographic-mass spectrometric techniques were used to identify metabolites of glutethimide excreted in human urine. In this study three monohydroxy metabolites, a dihydrodiol and three dihydroxy metabolites were detected after ingestion of the drug. The results indicate that the phenyl ring of glutethimide is metabolized by the epoxide-dihydrodiol pathway in the human following chronic administration of the drug.
D000293:Adolescent; D002849:Chromatography, Gas; D004852:Epoxy Compounds / Q000378:metabolism; D005260:Female; D005984:Glutethimide / Q000378:metabolism* / Q000652:urine; D006801:Humans; D006900:Hydroxylation; D013058:Mass Spectrometry
D004852:Epoxy Compounds; D005984:Glutethimide