The characteristics of succinylated con A induced growth inhibition of 3T3 cells in tissue culture.
The growth of untransformed 3T3 fibroblasts can be inhibited by dimeric, non-agglutinating concanavalin A prepared by succinylation (Suc-CON A). This growth inhibition is non-toxic, reversible, and specific for Suc-Con A binding; the cell density at which growth terminates is dependent upon the final cell number and independent of the initial (i.e., plating) density. The part of the cell cycle during which Suc-Con A can exert its growth inhibitory effect appears to be restricted to mitosis and/or early G-1 phase.
D000818:Animals; D002455:Cell Division / Q000187:drug effects*; D002478:Cells, Cultured; D003208:Concanavalin A / Q000031:analogs & derivatives* / Q000494:pharmacology; D003470:Culture Media; D005347:Fibroblasts; D051379:Mice; D008938:Mitosis / Q000187:drug effects; D013386:Succinates / Q000494:pharmacology; D013499:Surface Properties; D013936:Thymidine / Q000378:metabolism; D013997:Time Factors
D003470:Culture Media; D013386:Succinates; D003208:Concanavalin A; D013936:Thymidine