The effect of bile and of sodium taurocholate on the epithelial cell dynamics of the rat small intestine.
The absence of bile from the intestinal lumen of rats for a period of 48 hr led to: a decreased proliferative cell pool, reduced cell shedding, and a 50% decrease of the labeling index in the ileum. The constant duodenal perfusion of Na taurocholate for periods of 48, 60, 72, and 96 hr in animals with a biliary diversion was associated with: deepening of crypts and decreased crypt/villus ratios as well as with acceleration of the epithelial cell migration rate on the crypt-villus units. The data suggest that bile and bile acids constitute important regulatory factors influencing enterocyte proliferation, migration and loss.
D000818:Animals; D001646:Bile / Q000378:metabolism*; D002465:Cell Movement; D004247:DNA / Q000032:analysis / Q000096:biosynthesis; D004847:Epithelial Cells; D004848:Epithelium / Q000378:metabolism; D007263:Infusions, Parenteral; D007421:Intestine, Small / Q000032:analysis / Q000378:metabolism*; D009929:Organ Size; D011506:Proteins / Q000032:analysis; D051381:Rats; D013656:Taurocholic Acid / Q000008:administration & dosage / Q000494:pharmacology*
D011506:Proteins; D013656:Taurocholic Acid; D004247:DNA