The effects of preoperative irradiation on primary tracheal anastomosis.
Preoperative radiotherapy was used in the management of selected patients with cancer of the lung or trachea who might subsequently require segmental resection of bronchus or trachea and reconstruction by primary anastomosis. This study was designed to determine the effects of varying dosages of preoperative irradiation on anastomotic healing. Two rings were resected from the cervical trachea of 20 dogs following irradiation with varying doses of cesium. There were no important adverse effects on healing of the trachea or adjacent organs in dogs receiving up to 3,500 rads. All dogs receiving a higher dose than this developed some anastomotic stenosis, which was severe in 6 of 8 animals. Similar adverse effects were observed in 2 patients managed by preoperative radiotherapy (4,000 rads in three weeks) and tracheal resection with primary anastomosis.
D000818:Animals; D001984:Bronchial Neoplasms / Q000532:radiotherapy; D002588:Cesium Radioisotopes; D004285:Dogs; D004307:Dose-Response Relationship, Radiation; D004947:Esophagus / Q000528:radiation effects; D006801:Humans; D011830:Radiation Effects; D011833:Radiation Injuries, Experimental / Q000473:pathology; D013116:Spinal Cord / Q000528:radiation effects; D014132:Trachea / Q000473:pathology / Q000528:radiation effects / Q000601:surgery*; D014134:Tracheal Neoplasms / Q000532:radiotherapy; D014135:Tracheal Stenosis / Q000473:pathology; D014945:Wound Healing / Q000528:radiation effects*
D002588:Cesium Radioisotopes