[Simulation of cold acclimation by chronic treatment with noradrenaline, with special reference to metabolic responses to noradrenaline (author's transl)].
Rats treated with noradrenaline (NA) or L-dopa for 28 days were infused i.v. with NA for 30 min and changes in rectal temperature and plasma concentrations of nonesterified fatty acids (NEFA), glycerol, blood sugar, and lactate were observed. Results obtained were compared with those in cold-acclimated rats. The NA infusions caused a significant elevation of the rectal temperature in cold-acclimated and NA-treated rats, but not in L-dopa-treated ones. NA-induced increase in the plasma NEFA level was less in extent in cold-acclimated rats than in warm-adapted ones. Similar difference in the NEFA increase was observed between NA-treated and control rats. Changes in plasma glycerol level were the same in cold-acclimated and warm-adapted rats and in NA-treated and control rats. NA-induced increase in blood sugar level was less in extent in cold-acclimated and NA-treated rats as compared to the increase in respective control rats. No consistent changes were observed in blood lactate concentration. From the results it was inferred that the responses to exogenous NA in NA-treated rats, but not in L-dopa treated ones, were similar to those in cold-acclimated rats. It was thus suggested that the chronic treatment with NA may produce similar metabolic state as in cold-acclimation.
D000064:Acclimatization / Q000187:drug effects*; D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D001831:Body Temperature / Q000187:drug effects; D003080:Cold Temperature; D005230:Fatty Acids, Nonesterified / Q000097:blood; D005990:Glycerol / Q000097:blood; D007263:Infusions, Parenteral; D007271:Injections, Intradermal; D007773:Lactates / Q000097:blood; D007980:Levodopa / Q000008:administration & dosage / Q000494:pharmacology; D008297:Male; D008954:Models, Biological; D009638:Norepinephrine / Q000008:administration & dosage / Q000494:pharmacology*; D051381:Rats
D001786:Blood Glucose; D005230:Fatty Acids, Nonesterified; D007773:Lactates; D007980:Levodopa; D005990:Glycerol; D009638:Norepinephrine