Epileptogenic properties of folic acid and N5 methyltetrahydrofolate in cat.
The epileptogenic properties of folic acid and N5-methyltetrahydrofolate applied locally on the cortex were compared in cats. Neither substance was epileptogenic except in very high concentration, on the order of 10(-3) M. N5-Methyltetrahydrofolate, the folate derivative most widely distributed in the central nervous system and CSF of mammals, was not more epileptogenic than folic acid. Because the level of N5-methyltetrahydrofolate is only slightly diminished in patients treated with anticonvulsants, the change cannot account for the therapeutic effect of the drugs.
D000818:Animals; D000927:Anticonvulsants / Q000494:pharmacology; D002415:Cats; D002540:Cerebral Cortex / Q000187:drug effects; D003292:Convulsants; D004305:Dose-Response Relationship, Drug; D005260:Female; D005492:Folic Acid / Q000008:administration & dosage / Q000378:metabolism / Q000494:pharmacology*; D008297:Male; D012640:Seizures / Q000139:chemically induced; D013763:Tetrahydrofolates / Q000008:administration & dosage / Q000494:pharmacology*
D000927:Anticonvulsants; D003292:Convulsants; D013763:Tetrahydrofolates; D005492:Folic Acid