Inhibition of the metabolism of amino sugars with 2-deoxy-2-(2-fluoroacetamido)-alpha-D-glucopyranose.
The metabolism of amino sugars in extracts of mouse cells was studied by the use of 2-acetamido-2-deoxy-alpha-D-glucopyranose, 2-acetamido-2-deoxy-alpha-D-manno-pyranose, and N-acetylneuraminic acid as tracers with or without added 0.5mM 2-deoxy-2-(2-fluoroacetamido)-alpha-D-glucopyranosyl pyrophosphate) and cytidine 5'-(N-acetylneuraminyl monophosphate) was inhibited by the fluoro sugar.
D000081:Acetamides; D000255:Adenosine Triphosphate / Q000494:pharmacology; D000818:Animals; D002460:Cell Line; D002474:Cell-Free System; D003597:Cytosine Nucleotides / Q000494:pharmacology; D005461:Fluorine; D005944:Glucosamine / Q000031:analogs & derivatives* / Q000494:pharmacology; D006595:Hexosamines / Q000378:metabolism*; D007700:Kinetics; D051379:Mice; D012794:Sialic Acids / Q000378:metabolism; D013997:Time Factors; D014500:Uracil Nucleotides / Q000494:pharmacology
D000081:Acetamides; D003597:Cytosine Nucleotides; D006595:Hexosamines; D012794:Sialic Acids; D014500:Uracil Nucleotides; D005461:Fluorine; D000255:Adenosine Triphosphate; D005944:Glucosamine