Specifically cytotoxic human and mouse lymphoid cells induced with antibody or antigen-antibody complexes.
Human or mouse lymphoid cells could be "armed" with anti-NIP antibodies to become cytotoxic to NNP-conjugated fowl erythrocytes (NNP and NIP are closely related haptens). The arming factor was neutralized by a sufficient concentration of NIP-BSA (twice the concentration causing maximal precipitation) but low concentrations (e.g., 7% of the maximal precipitation concentration) increased the arming capacity.
D000818:Animals; D000906:Antibodies / Q000032:analysis; D000918:Antibody Specificity; D000936:Antigen-Antibody Complex; D002498:Centrifugation; D002645:Chickens; D003601:Cytotoxicity Tests, Immunologic; D004305:Dose-Response Relationship, Drug; D006358:Hot Temperature; D006801:Humans; D007106:Immune Sera / Q000302:isolation & purification; D007114:Immunization; D007074:Immunoglobulin G / Q000378:metabolism; D008214:Lymphocytes / Q000276:immunology*; D051379:Mice; D008808:Mice, Inbred CBA; D009592:Nitrohydroxyiodophenylacetate / Q000008:administration & dosage; D011817:Rabbits; D051381:Rats; D011919:Rats, Inbred Strains; D013045:Species Specificity; D013154:Spleen / Q000276:immunology
D000906:Antibodies; D000936:Antigen-Antibody Complex; D007106:Immune Sera; D007074:Immunoglobulin G; D009592:Nitrohydroxyiodophenylacetate