Lack of development, factor of congenital ureterohydronephrosis.
Female Swiss mice (25-30 g) received a single subcutaneous injection of 200 mug nucleotoxic substance (chloraminophen) on day 11 of pregnancy. The fetuses taken from the treated mother on day 18 show a significant lack of development and urinary anomalies, such as ureterohydronephrosis (26%) and renal agenesis (few cases). Ureterohydronephrosis seems to be caused by lacking development of the ureterovesical junction region.
D000014:Abnormalities, Drug-Induced; D000818:Animals; D002700:Chloramines; D003864:Depression, Chemical; D005260:Female; D006869:Hydronephrosis / Q000139:chemically induced* / Q000151:congenital; D051379:Mice; D014513:Ureter / Q000002:abnormalities* / Q000187:drug effects / Q000196:embryology
D002700:Chloramines