Passive transfer of experimental autoimmune myasthenia by lymph node cells in inbred guinea pigs.
Passive transfer of experimental autoimmune myasthenia (EAM) was performed with lymph node cells from donor guinea pigs immunized with purified acetylcholine receptor (AChR) from Torpedo californica. Recipient animals revealed the same clinical signs and electromyographic patterns as observed in actively challenged animals. These phenomena are parallel to the clinical manifestations of the human disease myasthenia gravis, in which cellular response to AChR was recently demonstrated.
D000109:Acetylcholine; D000818:Animals; D002452:Cell Count; D002470:Cell Survival; D003168:Complement Fixation Tests; D004491:Edrophonium / Q000008:administration & dosage; D004576:Electromyography; D004593:Electrophorus; D006168:Guinea Pigs; D007116:Immunization, Passive; D008198:Lymph Nodes / Q000276:immunology* / Q000637:transplantation; D009157:Myasthenia Gravis / Q000209:etiology / Q000276:immunology*; D011950:Receptors, Cholinergic; D012882:Skin Tests; D014184:Transplantation, Homologous
D011950:Receptors, Cholinergic; D004491:Edrophonium; D000109:Acetylcholine