Chronic granulomatous disease and the Kell blood groups.
Fifteen antigenic determinants are known to be related to the Kell blood group. Some boys with X-linked chronic granulomatous disease have the very rare McLeod or Ko phenotype on their red cells. Serological studies of the McLeod type suggest that the weak Kell antigens that are present differ qualitatively and quantitatively from those on red cells of common Kell type. A new antigen, Kx, has been characterized and shown to be present on red cells and neutrophil leucocytes. Lack of red-cell Kx is associated with the McLeod phenotype, lack of leucocyte Kx is associated with chronic granulomatous disease.
D000937:Antigen-Antibody Reactions; D001789:Blood Group Antigens; D001792:Blood Platelets / Q000276:immunology; D006105:Granulomatous Disease, Chronic / Q000097:blood*; D006801:Humans; D007626:Kell Blood-Group System; D008297:Male; D009504:Neutrophils / Q000276:immunology; D010585:Phagocyte Bactericidal Dysfunction / Q000097:blood*; D010641:Phenotype; D012730:Sex Chromosomes / Q000276:immunology
D001789:Blood Group Antigens; D007626:Kell Blood-Group System