Yttrium-90 citrate colloid for radioisotope synovectomy.
The preparation of an yttrium-90 citrate colloid is described. This formulation localizes in the synovial membrane and thereby eliminates any irradiation received by extra-articular tissues. Yttrium-90 is eluted from Sr-90 bound to a sulphonic acid ion exchange resin. The colloid is prepared using a 3:1 ratio of carrier yttrium and citrate. Contamination with ionic 90Y and ionic 90Sr was less than 1 percent and 0.001 percent, respectively. In the 28 patients studied, all of the injected dose of 90Y remained in the region of the joint. Brief clinical results are presented.
D000818:Animals; D001172:Arthritis, Rheumatoid / Q000532:radiotherapy*; D002951:Citrates / Q000378:metabolism; D003102:Colloids / Q000138:chemical synthesis*; D006801:Humans; D007270:Injections, Intra-Articular; D011817:Rabbits; D011830:Radiation Effects; D013583:Synovial Membrane / Q000378:metabolism / Q000528:radiation effects*; D013997:Time Factors; D015021:Yttrium Radioisotopes / Q000008:administration & dosage / Q000378:metabolism / Q000627:therapeutic use*
D002951:Citrates; D003102:Colloids; D015021:Yttrium Radioisotopes