Uptake of tritium labelled chloroquine into organized cultures of rat spinal ganglia. An electron microscope autoradiographic study.
Cultured spinal ganglia of the rat treated with 3-3H-chloroquine led to the formation of numerous multilamellated bodies (MLB) in the perikarya of neurons, satellite cells, and fibroblasts. Electron microscope autoradiography showed label over and near a considerable proportion of MLB. The action of chloroquine in MLB is discussed with regard to its effect upon lysosomes.
D000818:Animals; D001345:Autoradiography; D002738:Chloroquine / Q000378:metabolism*; D046508:Culture Techniques; D005347:Fibroblasts / Q000378:metabolism; D005727:Ganglia, Spinal / Q000378:metabolism*; D008247:Lysosomes / Q000378:metabolism; D008854:Microscopy, Electron; D009474:Neurons / Q000378:metabolism; D051381:Rats; D014316:Tritium
D014316:Tritium; D002738:Chloroquine