[Effects of drugs on cell culture (II)].
The toxicity of drugs was determined using embryonic skin and muscle from humans (Flow 1,000). The dosage causing a 50% inhibition culture growth (ID50) and minimum concentration, caused by the detachment of the cell from the vessel wall, were determined. ID50 values of ibuprofen, naproxen, Y-5554, dichlofenac and aminopyrine were found to be 150, 320,220, 110 and greater 500 mug/ml respectively. Minimum concentration, caused by the detachment of the from the vessel wall, was as follows: ibuprofen 250, naproxen 250-500, Y-5554 250-500, dichlofenac 62.50-125 and aminopyrine 1,000-2,000 mug/ml respectively.
D000632:Aminopyrine / Q000633:toxicity; D002455:Cell Division / Q000187:drug effects; D002460:Cell Line; D004305:Dose-Response Relationship, Drug; D004353:Drug Evaluation, Preclinical / Q000379:methods*; D004622:Embryo, Mammalian; D005347:Fibroblasts / Q000187:drug effects*; D006801:Humans; D007052:Ibuprofen / Q000633:toxicity; D009132:Muscles; D009288:Naproxen / Q000633:toxicity; D010648:Phenylacetates / Q000633:toxicity; D012867:Skin; D014966:Xanthenes / Q000633:toxicity
D010648:Phenylacetates; D014966:Xanthenes; D000632:Aminopyrine; D009288:Naproxen; D007052:Ibuprofen