[N 1-nicotinoyl and isonicotinoylpyrazoles].
Synthesis of twelve N 1-nicotinoyl and isonicotinoylpyrazoles by reaction of 4,5-tetra-, penta-, hexamethylenepyrazoles, dihydronaphtopyrazole, bornylenepyrazole and cineolylenepyrazole with nicotinoyl and isonicotinoylchloride, is described. The structure of N 1-derivatives of these compounds was ascertained by comparison of N.M.R. spectra with those of 1-nicotinoyl and 1-isonicotinoyl-4,5-pentamethylene-5-hydroxy-2-pyrazoline, obtained by reaction of 2-hydroxymethylenecycloheptanone with nicotinoyl and isonicotinoylhydrazide, respectively. N 1-isonicotinoylbornylenepyrazole shows weak C.N.S. depression, muscle relaxation and anticonvulsant activity.
D000818:Animals; D000927:Anticonvulsants / Q000138:chemical synthesis; D002490:Central Nervous System / Q000187:drug effects; D007202:Indicators and Reagents; D007539:Isonicotinic Acids / Q000138:chemical synthesis / Q000494:pharmacology; D009682:Magnetic Resonance Spectroscopy; D051379:Mice; D009125:Muscle Relaxants, Central / Q000138:chemical synthesis; D009539:Nicotinic Acids / Q000138:chemical synthesis* / Q000494:pharmacology; D011720:Pyrazoles / Q000138:chemical synthesis* / Q000494:pharmacology
D000927:Anticonvulsants; D007202:Indicators and Reagents; D007539:Isonicotinic Acids; D009125:Muscle Relaxants, Central; D009539:Nicotinic Acids; D011720:Pyrazoles
N1-nicotinoil e isonicotinoilpirazoli