"A spoonful of sugar" - trans-alveolar nutrition.
In this initial study, it has been postulated that even the simple bronchial administration of isotonic glucose and insulin can maintain alveolar cell metabolism as measured by A.T.P. activity; further studies, using aerosolized glucose solutions, will test the validity of the hypothesis that alveolar metabolism can be maintained by the administration of substrate in aerosolized form by the alveolar route and will determine whether this form of substrate administration has clinical potential.
D000255:Adenosine Triphosphate / Q000378:metabolism; D000818:Animals; D001980:Bronchi; D004734:Energy Metabolism; D005947:Glucose / Q000008:administration & dosage / Q000494:pharmacology; D007328:Insulin / Q000008:administration & dosage / Q000494:pharmacology; D007552:Isotonic Solutions; D007773:Lactates / Q000378:metabolism*; D011650:Pulmonary Alveoli / Q000166:cytology / Q000378:metabolism*; D011663:Pulmonary Surfactants / Q000096:biosynthesis; D011817:Rabbits
D007328:Insulin; D007552:Isotonic Solutions; D007773:Lactates; D011663:Pulmonary Surfactants; D000255:Adenosine Triphosphate; D005947:Glucose