The effect of uremic serum on normal human and guinea pig lymphocytes.
Incubation of normal 51-Cr-labeled human and guinea pig lymphocytes with uremic serum or guanidinosuccinic acid did not cause an increase in 51-Cr release. Electron microscopic examination of these lymphocytes revealed no abnormalities. It is suggested that the lymphocytopenia of uremia is not due to increased destruction of cells but may be a result of redistribution to other body compartments.
D000818:Animals; D006146:Guanidines / Q000633:toxicity; D006168:Guinea Pigs; D006801:Humans; D008214:Lymphocytes / Q000187:drug effects; D008231:Lymphopenia / Q000209:etiology*; D013386:Succinates / Q000633:toxicity; D014511:Uremia / Q000097:blood*
D006146:Guanidines; D013386:Succinates