The influence of donor characteristics and preparation methods on the potency of human cryoprecipitate.
An investigation of the influence of donor characteristics and preparative procedural variation on the potency of human cryoprecipitate was carried out on 30 whole blood and 139 plasmapheresis donors. Recovery of plasma Factor VIII in cryoprecipitate ranged from 11.2 to 89.4 per cent (average, 38 +/- 18%). The Factor VIII content of bags of cryoprecipitate ranged from 29 to 379 units (average, 111 +/- 77 units). No difference existed between whole blood donors and regular plasmapheresis donors. The only donor characteristic which was related to the potency of cryoprecipitate was the plasma concentration of Factor VIII which varied as much as sixfold on repeated visits of the same donor. The findings indicate that, within the limitations imposed by the regulations of the American Association of Blood Banks and the practicalities of an ordinary blood bank workload, no donor characteristic or variation in preparative procedures was of predictive value in obtaining cryoprecipitate of high potency. The potency of cryoprecipitate from individual donors appears to be related to factors inherent in the donor plasma itself.
D000925:Anticoagulants / Q000494:pharmacology; D001782:Blood Donors; D001792:Blood Platelets; D011232:Chemical Precipitation; D003450:Cryoglobulins; D005169:Factor VIII / Q000378:metabolism; D006801:Humans; D007053:Ice; D010956:Plasmapheresis
D000925:Anticoagulants; D003450:Cryoglobulins; D007053:Ice; D005169:Factor VIII