Levels of piribedil and its active metabolite (S-584) in the rat striatum.
1. A gas chromatographic-mass fragmentographic method has been developed to determine piribedil and its metabolite S-584, using diazepam as internal standard. The metabolite was derivatized as a trimethylsilyl ether for gas chromatographic analysis. The minimum detectable amount of piribedil and the metabolite was 10 ng/g tissue. 2. Levels of piribedil and its metabolite in the striatum were determined by mass fragmentography.
D000818:Animals; D003342:Corpus Striatum / Q000032:analysis*; D003975:Diazepam; D005260:Female; D008401:Gas Chromatography-Mass Spectrometry; D007274:Injections, Intraperitoneal; D010879:Piperazines / Q000032:analysis*; D010891:Piribedil / Q000008:administration & dosage / Q000031:analogs & derivatives / Q000032:analysis* / Q000378:metabolism; D051381:Rats
D010879:Piperazines; C006113:1-(2-pyrimidyl)-4-(3,4-dihydroxybenzyl)piperazine; D010891:Piribedil; D003975:Diazepam