The effect of intramuscular and intramammary vaccination of cows on antibody levels and resistance to intramammary infection by Staphylococcus aureus.
Cows were vaccinated simultaneously by the intramuscular and intramammary route with formolised Staphylococcus aureus cells of strains BB, Mexi and 3528. Vaccination resulted in slight increases in serum agglutinin titres, but the levels of the agglutinins in milk and colostrum were not higher in vaccinated cows than in the unvaccinated controls. Vaccination did not result in higher levels of IgM, IgG1, IgG2 or IgA immunoglobulins in serum, colostrum or milk as compared with controls. Vaccinated cows, particularly those in which strain 3528 was used, showed some resistance to infection following challenge with low numbers of viable S aureus Mexi, but there was no resistance to infection when similar numbers of the virulent BB strain were used for challenge. It is concluded that vaccination is unlikely to prevent infection of the bovine udder by S aureus.
D000818:Animals; D000907:Antibodies, Bacterial / Q000032:analysis; D000917:Antibody Formation; D002417:Cattle / Q000276:immunology*; D003126:Colostrum / Q000276:immunology; D005260:Female; D007070:Immunoglobulin A / Q000032:analysis; D007074:Immunoglobulin G / Q000032:analysis; D007075:Immunoglobulin M / Q000032:analysis; D007267:Injections; D007273:Injections, Intramuscular; D008321:Mammary Glands, Animal; D008414:Mastitis, Bovine / Q000276:immunology*; D008892:Milk / Q000276:immunology; D011247:Pregnancy; D013203:Staphylococcal Infections / Q000662:veterinary*; D013209:Staphylococcal Vaccines / Q000008:administration & dosage; D013211:Staphylococcus aureus / Q000276:immunology*; D013682:Teichoic Acids / Q000276:immunology; D014611:Vaccination / Q000662:veterinary*
D000907:Antibodies, Bacterial; D007070:Immunoglobulin A; D007074:Immunoglobulin G; D007075:Immunoglobulin M; D013209:Staphylococcal Vaccines; D013682:Teichoic Acids