Comparison of the bioavailability of cyanocobalamin from capsule and liquid dosage forms.
Comparative in vivo absorption of cyanocobalamin from two dosage forms, gelatin capsule and liquid, was studied. Forty-two subjects received simultaneous doses of cyanocobalamin in capsule and liquid form, labeled with cobalt-57 and cobalt-60, respectively. Excretion, a measure of absorption, was between 2 percent and 66 percent greater with the liquid form. In vitro dissolution studies showed that the capsules had a tendency to collapse into a stringy mass and to dissolve slowly.
D001682:Biological Availability; D002214:Capsules; D003037:Cobalt Radioisotopes; D006801:Humans; D007408:Intestinal Absorption; D012995:Solubility; D012996:Solutions; D013997:Time Factors; D014805:Vitamin B 12 / Q000008:administration & dosage / Q000378:metabolism*
D002214:Capsules; D003037:Cobalt Radioisotopes; D012996:Solutions; D014805:Vitamin B 12