Synthesis and preliminary pharmacologic studies on 1-(4-pyridyl)- and 6-methoxy-1-(4-pyridyl)-beta-carboline.
1-(4-pyridyl) and 6-methoxy-1-(4-pyridyl)-beta-carboline were synthesized by dehydrogenation of 1-(4-pyridyl)-1,2-3,4-tetrahydro-beta-carboline and 6-methoxy-1-(4-pyridyl)-1,2,3,4-tetrahydro-beta-carboline, and their central action was studied pharmacologically. In the doses employed neither preparation showed significant sedative, analgesic or antidepressant activity.
D000662:Amphetamines / Q000494:pharmacology; D000700:Analgesics; D000818:Animals; D000928:Antidepressive Agents; D001831:Body Temperature / Q000187:drug effects; D002243:Carbolines / Q000138:chemical synthesis / Q000494:pharmacology; D007211:Indoles; D008297:Male; D051379:Mice; D009043:Motor Activity / Q000187:drug effects; D010433:Pentylenetetrazole; D011725:Pyridines / Q000138:chemical synthesis / Q000494:pharmacology; D012640:Seizures / Q000139:chemically induced / Q000517:prevention & control
D000662:Amphetamines; D000700:Analgesics; D000928:Antidepressive Agents; D002243:Carbolines; D007211:Indoles; D011725:Pyridines; D010433:Pentylenetetrazole