DNA repair and UV resistance in human melanoma.
Human melanoma cells are highly resistant to 254-nm light. Resistance appears to depend on their ability to continue replication after high UV doses due to the presence of a very efficient postreplication repair system, while excision-repair is of relatively minor importance.
D002478:Cells, Cultured; D004260:DNA Repair; D004273:DNA, Neoplasm / Q000096:biosynthesis / Q000528:radiation effects*; D006801:Humans; D008545:Melanoma / Q000378:metabolism*; D011830:Radiation Effects; D013936:Thymidine / Q000378:metabolism; D014466:Ultraviolet Rays
D004273:DNA, Neoplasm; D013936:Thymidine