Cytogenetic analysis of X-ray-induced chromosome aberrations in spontaneously leukaemic AKR mice.
The increased frequency of numerical and structural chromosomal aberrations in spontaneously leukaemic AKR mice, compared with the values of healthy control CBA/H-T6T6 mice, induced by X-irradiation, migh be connected with the predisposition to malignant growth, probably indirectly helping the virus activation, or acting together with the immune deficiency, by creating a weaker system that is more sensitive to carcinogenic agents.
D000782:Aneuploidy; D000818:Animals; D001772:Blood Cell Count; D002869:Chromosome Aberrations; D002875:Chromosomes / Q000528:radiation effects; D005260:Female; D007621:Karyotyping; D007945:Leukemia, Lymphoid / Q000235:genetics; D008297:Male; D051379:Mice; D008806:Mice, Inbred AKR; D008808:Mice, Inbred CBA; D008940:Mitotic Index; D011831:Radiation Genetics; D014965:X-Rays