The effects of 5-fluorouracil on prostatic DNA synthesis.
A new animal model has been developed for studying the effects of nonhormonal drugs on the androgen-induced growth of the rat prostate. The antimetabolite 5-fluorouracil caused a 60 per cent reduction of the rate of prostatic DNA synthesis in androgen-stimulated castrate rats. This drug did not decrease the size of the prostate in normal intact animals and did not exhibit significant antiandrogenic activity. Its distribution is primarily in the acid-soluble fraction of the total prostatic homogenate.
D000818:Animals; D002369:Castration; D004247:DNA / Q000096:biosynthesis*; D005472:Fluorouracil / Q000494:pharmacology*; D008297:Male; D008954:Models, Biological; D009929:Organ Size / Q000187:drug effects; D011467:Prostate / Q000187:drug effects / Q000378:metabolism*; D051381:Rats; D013739:Testosterone / Q000494:pharmacology
D013739:Testosterone; D004247:DNA; D005472:Fluorouracil