Actions of gamma-aminobutyric acid on sympathetic ganglion cells.
1. Responses of single ganglion cells in the isolated rat superior cervical ganglion to gamma-aminobutyric acid (GABA) applied via the bathing medium were recorded using intracellular micro-electrodes. 2. GABA produced a large fall in cell input resistance, frequently to immeasurable levels. In thirteen cells showing a modest response to 100 muM GABA, input resistance fell from 50-5 +/-9-5 to 15.9 +/- 3-2 Momega (means +/- S.E. of mean). After correction for resistance leaks introduced by the impaling electrode, the resting membrane resistance Rm and the resistance of the GABA-shunt Rg in these cells were calculated to be 79-3 +/- 16-6 and 35-0 +/- 9-5 Momega respectively. 3. Cells with recorded resting membrane potentials greater than -42 mV were depolarized by GABA; at resting potential less than -42 mV they were hyperpolarized...
D000613:Aminobutyrates / Q000494:pharmacology*; D000818:Animals; D001965:Bromides / Q000494:pharmacology; D002463:Cell Membrane Permeability / Q000187:drug effects; D002572:Cervical Plexus; D002712:Chlorides / Q000494:pharmacology; D002794:Choline / Q000494:pharmacology; D004594:Electrophysiology / Q000187:drug effects; D005725:Ganglia, Autonomic / Q000187:drug effects*; D005971:Glutamates / Q000494:pharmacology; D066298:In Vitro Techniques; D007513:Isethionic Acid / Q000494:pharmacology; D008564:Membrane Potentials / Q000187:drug effects; D009474:Neurons / Q000187:drug effects; D051381:Rats; D013431:Sulfates / Q000494:pharmacology; D005680:gamma-Aminobutyric Acid / Q000494:pharmacology*
D000613:Aminobutyrates; D001965:Bromides; D002712:Chlorides; D005971:Glutamates; D013431:Sulfates; D005680:gamma-Aminobutyric Acid; D007513:Isethionic Acid; D002794:Choline