Studies on the cytogenetic activity of some common fungicides in higher plants.
Seeds of barley and secondary roots of Vicia faba were exposed to treatments with 23 of the most commonly used fungicides with a view to discovering the effect of these fungicides on the germination, seedling injury and chromosome abnormalities in the former, and the spectrum and frequency of chromosomal aberrations in the latter. Sixteen fungicides reduced the percentage of seed germination, induced seedling injury and produced cytological anomalies of varying degrees in barley. More potent fungicides were further tested in the secondary roots of Vicia faba which were found to produce a significant amount of chromosomal aberrations in the form of chromatid and isolocus breaks and exchanges of chromatid type. Based on theseo bservations, fungicides Dexon, Benlaté, Cerasan, Copperson, Lonocol, Morestan, Hexasan and Karathane could be classified as strong radioimimetic agents. Their role as environmental mutagens in enhancing the spontaneous mutation rate has been discussed and it has been concluded that these constitute genetic and environmental hazards of great magnitude to the eco-system where they are released.
D000577:Amides / Q000494:pharmacology; D002219:Carbamates / Q000494:pharmacology; D002254:Carbonates / Q000494:pharmacology; D002842:Chromatids / Q000187:drug effects; D002869:Chromosome Aberrations; D003300:Copper / Q000494:pharmacology; D003437:Crotonates / Q000494:pharmacology; D005659:Fungicides, Industrial / Q000145:classification / Q000494:pharmacology*; D001467:Hordeum / Q000187:drug effects / Q000254:growth & development; D008628:Mercury / Q000494:pharmacology; D008938:Mitosis / Q000187:drug effects; D009153:Mutagens; D063245:Plant Development; D010944:Plants / Q000187:drug effects*; D013307:Streptomycin / Q000494:pharmacology; D013455:Sulfur / Q000494:pharmacology
D000577:Amides; D002219:Carbamates; D002254:Carbonates; D003437:Crotonates; D005659:Fungicides, Industrial; D009153:Mutagens; D013455:Sulfur; D003300:Copper; D008628:Mercury; D013307:Streptomycin