[Deoxyribonucleases in spontaneous and experimental tumors of the nervous system].
DNA- and RNA-concentrations, as well as in vitro activities of DNase I (EC 3.1.4.5), DNase II (EC 3.1.4.6), and DNase I inhibitor, have been determined in 63 spontaneous (man) and 22 experimentally induced (rat) nervous system blastomas of various types and of different degrees of malignancy. Generally, a distinct elevation of DNA concentrations and of the ratio (Q) of DNase II- to DNase I-activities has been observed when compared with control values. A statistically significant relationship could be demonstrated between increase of DNA concentrations and Q in experimentally induced neurinomas of rats as well as in human astrocytomas and glioblastomas. Whereas the increase of Q may be a biochemical expression of elevated DNA synthesis of tumour cells, no conclusions can be drawn as to the role of DNases in the process of malignant transformation.
D000818:Animals; D001254:Astrocytoma / Q000139:chemically induced / Q000201:enzymology; D001932:Brain Neoplasms / Q000139:chemically induced / Q000201:enzymology*; D003851:Deoxyribonucleases / Q000037:antagonists & inhibitors / Q000378:metabolism*; D006801:Humans; D009374:Neoplasms, Experimental / Q000139:chemically induced; D009442:Neurilemmoma / Q000139:chemically induced / Q000201:enzymology; D009837:Oligodendroglioma / Q000139:chemically induced / Q000201:enzymology; D010524:Peripheral Nervous System Neoplasms / Q000139:chemically induced / Q000201:enzymology*; D051381:Rats; D014226:Triazenes; D000159:Vestibulocochlear Nerve
D014226:Triazenes; D003851:Deoxyribonucleases
Desoxyribonucleasen in spontanen und experimentellen Tumoren des Nervensystems