[Effect of rubratoxin B on the respiration of liver mitochondria in the rat].
The in vitro effect of rubratoxin B on the electron transport system of rat liver mitochondira was investigated. This mycotoxin depressed oxygen consumption in ADP-lacking mitochondira and in ADP-coupled mitochondria, using succinate or beta-hydroxybutyrate as substrats. Rubratoxin B is neither an oxidative-phosphorylation inhibitor nor uncoupling agent. Its effect is compared with aflatoxin B1.
D000244:Adenosine Diphosphate / Q000378:metabolism; D000255:Adenosine Triphosphate / Q000096:biosynthesis; D000818:Animals; D006885:Hydroxybutyrates / Q000378:metabolism; D008297:Male; D008930:Mitochondria, Liver / Q000378:metabolism*; D009183:Mycotoxins / Q000494:pharmacology*; D010101:Oxygen Consumption / Q000187:drug effects*; D051381:Rats; D013386:Succinates / Q000378:metabolism
D006885:Hydroxybutyrates; D009183:Mycotoxins; D013386:Succinates; D000244:Adenosine Diphosphate; D000255:Adenosine Triphosphate
Action de la rubratoxine B sur la respiration des mitochondries hépatiques de rat