The effect of imidazole and some of its derivatives on the guinea pig isolated auricles and frog nerve-muscle junction.
Imidazole and its simple derivatives exerted an positive inotropic action on isolated guinea pig heart auricles. The order activity was 2-Etlm greater than greater than 2-MeIm greater than N-MeIm greater than Im. The action of Im on heart auricles was partially blocked by mepyramine, but not by burmamide. Im and 2-MeIm increased EPP's amplitude and produced a generation of full spike potentials in fatigued nerve-muscle preparation. Both Im acts in absence of calcium from Ringer's solution. Possibility of the Im action as free calcium ions regulator is discussed.
D000200:Action Potentials / Q000187:drug effects; D000818:Animals; D001001:Anura; D002712:Chlorides / Q000494:pharmacology; D003864:Depression, Chemical; D004305:Dose-Response Relationship, Drug; D005246:Feedback; D006168:Guinea Pigs; D006321:Heart / Q000187:drug effects*; D006325:Heart Atria / Q000187:drug effects; D006632:Histamine / Q000494:pharmacology; D007093:Imidazoles / Q000494:pharmacology*; D008274:Magnesium / Q000494:pharmacology; D008564:Membrane Potentials / Q000187:drug effects; D009469:Neuromuscular Junction / Q000187:drug effects*; D013268:Stimulation, Chemical; D013997:Time Factors; D014403:Tubocurarine / Q000494:pharmacology
D002712:Chlorides; D007093:Imidazoles; D006632:Histamine; D008274:Magnesium; D014403:Tubocurarine