Cholesterol esterification and lipids in plasma and liver from newborn and young guinea pigs raised on milk and non-milk diet.
Plasma lecithin:cholesterol acyltransfer (LCAT), liver acyl-CoA:cholesterol acyltransfer (ACAT) and plasma and liver lipids were examined in newborn and young guinea pigs fed ordinary or a non-milk diet. LCAT in newborns was about 70% of the adult value, increased the first 3 days to values about three times the adult value, and decreased during the next 3 weeks to about adult value. Plasma lipids varied in a similar way. Liver ACAT in newborns was considerably higher than in adults. In young animals on non-milk diet the LCAT and ACAT were lower than in normally fed animals. LCAT was positively correlated to free cholesterol in plasma.
D000217:Acyltransferases / Q000097:blood / Q000378:metabolism; D000818:Animals; D002784:Cholesterol / Q000097:blood / Q000378:metabolism*; D002788:Cholesterol Esters / Q000097:blood / Q000378:metabolism; D003065:Coenzyme A / Q000097:blood / Q000378:metabolism; D004032:Diet; D004951:Esterification; D005260:Female; D005990:Glycerol / Q000097:blood / Q000378:metabolism; D006168:Guinea Pigs; D050356:Lipid Metabolism; D008099:Liver / Q000201:enzymology / Q000378:metabolism*; D008297:Male; D008892:Milk; D007862:Phosphatidylcholine-Sterol O-Acyltransferase / Q000097:blood / Q000378:metabolism; D014280:Triglycerides / Q000097:blood / Q000378:metabolism*
D002788:Cholesterol Esters; D014280:Triglycerides; D002784:Cholesterol; D000217:Acyltransferases; D007862:Phosphatidylcholine-Sterol O-Acyltransferase; D005990:Glycerol; D003065:Coenzyme A