Endocarditis caused by Rhodotorula successfully treated with 5-fluorocytosine.
A 7-year-old boy suffering from aortic regurgitation and mitral stenosis and regurgitation was admitted with endocarditis caused by Rhodotorula pilimanae and was treated successfully with orally administered antifungal agent, namely 5-fluorocytosine (5-FC). A dose of 100 mg per kg body weight, divided into four equal parts, was prescribed. After a prolonged febrile period his temperature dropped to normal on the fourth day of 5-FC therapy. Review of the published reports disclosed few cases of endocarditis due to Rhodotorula spp. and this case seems to be the first treated with 5-FC. Follow-up in one year, after discharge from the hospital, revealed no evidence of relapse.
D000284:Administration, Oral; D000935:Antifungal Agents / Q000627:therapeutic use; D001022:Aortic Valve Insufficiency / Q000150:complications; D002177:Candidiasis / Q000188:drug therapy*; D002648:Child; D003596:Cytosine / Q000008:administration & dosage / Q000031:analogs & derivatives*; D004696:Endocarditis / Q000150:complications / Q000188:drug therapy*; D005437:Flucytosine / Q000627:therapeutic use*; D006801:Humans; D007958:Leukocyte Count; D008297:Male; D003904:Mitosporic Fungi / Q000472:pathogenicity; D008944:Mitral Valve Insufficiency / Q000150:complications; D008946:Mitral Valve Stenosis / Q000150:complications
D000935:Antifungal Agents; D003596:Cytosine; D005437:Flucytosine