The search for new drugs in the group of xanthine derivatives. XXXIX - Reaction of 1,2-epoxycyclohexane with theophylline and 8-halotheophyllines.
Reaction of 1,2-epoxycyclohexane with theophylline and 8-halotheophyllines in n-butanol n-propanol DMF medium brought up a good yield of the corresponding trans-diequatorial-DL-7-(2'-hydroxycyclohexyl-1')-derivatives (I - III). The products (VII - IX), (XII), (XIII) were formed by nucleophilic displacement of the halogen of (II) or (III) by alkoxides or cyclamines. Acid hydrolysis of the alkoxy derivatives (VII -IX) gave the same compound:  1,3-dimethyl-trans-diequatorial-DL-7-(2'-hydroxycyclohexyl-1')-uric acid (X). The structures of these products were confirmed by U.V., I.R. and N.M.R. spectroscopy.
D003510:Cyclohexanes; D006868:Hydrolysis; D007202:Indicators and Reagents; D009682:Magnetic Resonance Spectroscopy; D013056:Spectrophotometry, Ultraviolet; D013806:Theophylline / Q000031:analogs & derivatives; D014970:Xanthines / Q000138:chemical synthesis*
D003510:Cyclohexanes; D007202:Indicators and Reagents; D014970:Xanthines; D013806:Theophylline