Anti-inflammatory action of an s-triazine derivative in rats.
Anti-inflammatory action of an s-triazine derivate (M 1704, 2-amino-4-(p-fluoroanilino)-6-n-propyl-1,3,5-triazine) was studied in rats. M 1704 inhibited carrageenan edema, cotton-pellet granuloma and adjuvant arthritis in intact rats. M 1704 was not effective on carrageenan edema in adrenalectomized rats, but effective when administered with cortisol. The drug appeared to potentiate the anti-inflammatory effects of cortisol on cotton-pellet granuloma. The results obtained in this and a previous study suggest that M 1704 exerts the anti-inflammatory action mainly by potentiating the peripheral anti-inflammatory action of endogenous steroid and partly by stimulating the secretion of corticosteroids.
D000287:Administration, Topical; D000315:Adrenalectomy; D000814:Aniline Compounds / Q000627:therapeutic use; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use*; D001172:Arthritis, Rheumatoid / Q000188:drug therapy / Q000276:immunology; D001241:Aspirin / Q000627:therapeutic use; D002351:Carrageenan; D004353:Drug Evaluation, Preclinical; D004487:Edema / Q000139:chemically induced / Q000188:drug therapy; D005620:Freund's Adjuvant; D006099:Granuloma / Q000188:drug therapy; D006854:Hydrocortisone / Q000627:therapeutic use; D008297:Male; D051381:Rats; D013997:Time Factors; D014227:Triazines / Q000627:therapeutic use*
D000814:Aniline Compounds; D000893:Anti-Inflammatory Agents; D014227:Triazines; D002351:Carrageenan; D005620:Freund's Adjuvant; D001241:Aspirin; D006854:Hydrocortisone