Induction of ovarian tumor in rats with N-butylnitrosourea.
Considerable number (8.2 approximately 10.7%) of ovarian tumors were produced in Sprague-Dawley adult rats treated with multiple oral or intramuscular administration of heavy doses of N-butylnitrosourea. Histologically the tumor was a clear-cell adenma which reminded of embryonal testicular tissue. Electron micrograph revealed secretory function of the tumor cells. It was not possible to find histogenesis in the normal ovarian components.
D000236:Adenoma / Q000139:chemically induced; D000818:Animals; D002273:Carcinogens; D005260:Female; D009374:Neoplasms, Experimental / Q000139:chemically induced; D009607:Nitrosourea Compounds; D010051:Ovarian Neoplasms / Q000139:chemically induced*; D051381:Rats
D002273:Carcinogens; D009607:Nitrosourea Compounds