Lack of effect of rifampin on the antibody response to a viral antigen in patients with tuberculosis.
Twenty-three volunteer patients with pulmonary tuberculosis were studied for the effect of rifampin on humoral immunity. The patients were matched for age and body weight with other patients not on rifampin treatment. Antibodies to influenza virus were measured 18 days after immunization. At the clinical doses used and for the periods of treatment between 3 and 8 months no difference in humoral immune response was observed between patients treated with rifampin and the control subjects. All but one treated patient showed an increase of antibody titers after vaccination.
D000328:Adult; D000368:Aged; D000917:Antibody Formation / Q000187:drug effects*; D000956:Antigens, Viral; D006801:Humans; D008297:Male; D008875:Middle Aged; D009975:Orthomyxoviridae / Q000276:immunology*; D012293:Rifampin / Q000494:pharmacology / Q000627:therapeutic use*; D014397:Tuberculosis, Pulmonary / Q000188:drug therapy* / Q000276:immunology
D000956:Antigens, Viral; D012293:Rifampin