The effect of the size of the gastric outlet on gastric emptying after vagotomy for duodenal ulcer.
Gastric emptying of isotopically labelled solid meals was studied in normal human subjects and in 30 patients who had had an operation for chronic duodenal ulcer. Each patient had a vagotomy of the whole stomach combined with either a Finney pyloroplasty to produce a large gastric outlet or a Heineke-Mikulicz pyloroplasty to produce a relatively small outlet. At 10-22 days after operation gastric emptying was equally and significantly slowed in both groups when compared with the normal controls. This delay occurred regardless of whether the vagotomy was complete or incomplete. At 4-6 months after operation emptying had returned to normal in the patients who had had a Finney pyloroplasty but remained significantly slowed after Heineke-Mikulicz pyloroplasty. Mild symptoms of gastric stasis frequently occurred in both groups in the early postoperative period, but were rare 4-6 months after operation. There was no correlation between the incidence of these early symptoms of stasis and the size of the gastric outlet constructed.
D000328:Adult; D000368:Aged; D002908:Chronic Disease; D004063:Digestion; D004381:Duodenal Ulcer / Q000503:physiopathology / Q000601:surgery*; D005260:Female; D005769:Gastrointestinal Motility; D006801:Humans; D008297:Male; D008875:Middle Aged; D011183:Postoperative Complications; D011708:Pylorus / Q000601:surgery*; D013270:Stomach / Q000503:physiopathology; D014628:Vagotomy