Urinary excretion of steroids and response to oophorectomy in premenopausal women with advanced breast cancer.
Relationship between the urinary excretion of steroids in premenopausal Japaneses patients with advanced breast cancer and their response to oophorectomy was studied. The estrogen fractions were determined by radioimmunoassay and those who responded to oophorectomy showed higher levels of 17 beta-estradiol than the non-responders before surgery. The high levels of urinary 17 beta-estradiol of the responders dropped markedly after oophorectomy. On the contrary, the non-responders showed relatively low levels of urinary excretion of 17 beta-estradiol before oophorectomy and the levels appeared either unchanged or slightly elevated after surgery. No definite relation was found between changes in the urinary excretion of estrone or estriol and the clinical effect of oophorectomy. Excretion of 17-ketosteroids in the responders was lower than that of the non-responders.
D015065:17-Hydroxycorticosteroids / Q000652:urine; D015068:17-Ketosteroids / Q000652:urine; D000305:Adrenal Cortex Hormones / Q000652:urine*; D000328:Adult; D001943:Breast Neoplasms / Q000628:therapy / Q000652:urine*; D002369:Castration; D004958:Estradiol / Q000652:urine; D004964:Estriol / Q000652:urine; D004967:Estrogens / Q000652:urine*; D004970:Estrone / Q000652:urine; D005260:Female; D006801:Humans; D008593:Menopause; D008875:Middle Aged; D009362:Neoplasm Metastasis
D015065:17-Hydroxycorticosteroids; D015068:17-Ketosteroids; D000305:Adrenal Cortex Hormones; D004967:Estrogens; D004970:Estrone; D004958:Estradiol; D004964:Estriol