Rapid onset of hyporesponsiveness to interferon induction on re-exposure to polyribonucleotide.
Only doses of complexed polyriboinosinic: polyribocytidylic acids sufficient to induce interferon, stimulated hyporesponsiveness to re-induction in rabbit kidney cells. Results of experiments designed to delineate the earliest time of appearance of hyporesponsiveness suggested the time of onset was less than i h after the end of a i h exposure to the inducer. The duration of hyporesponsiveness was about 24 h. Interferon itself did not produce hyporesponsiveness. Hence hyporesponsiveness must be related to an event or a substance synthesized before interferon production. The best candidate is a control protein inhibiting interferon production which is rapidly synthesized following exposure to an inducer.
D000818:Animals; D002478:Cells, Cultured / Q000187:drug effects / Q000378:metabolism; D007372:Interferons / Q000096:biosynthesis*; D007668:Kidney; D011070:Poly I-C / Q000494:pharmacology*; D011817:Rabbits
D007372:Interferons; D011070:Poly I-C