[Change in the rhythm of the enzyme activity of the liver in white rats during the chronic action of vinylacetate].
Experiments were conducted on male albino rats for 5 months; the activity of the liver aspartic and alaninaminotransferases underwent cyclic synchronized variations. Chronic 24-hour inhalation of vinylacetate in a concentration of 2.4 mg/m3 caused a transformation of the rhythms of these variations with the preservation of synchronization in the changes of the activity of the enzymes under study. With a greater concentration of vinylacetate (13.2 and 68 mg/m3) inducing chronic intoxication, desynchronization of transaminase variations was seen in the liver. A posssibility of correlation analysis use for determining the extent of synchronization in the activity of the enzymatic systems for the purpose of estimation of the toxic effect of the poisons is discussed.
D000085:Acetates / Q000506:poisoning; D000410:Alanine Transaminase / Q000378:metabolism*; D000818:Animals; D001219:Aspartate Aminotransferases / Q000378:metabolism*; D056486:Chemical and Drug Induced Liver Injury / Q000201:enzymology*; D008099:Liver / Q000187:drug effects* / Q000201:enzymology; D010507:Periodicity; D051381:Rats; D014753:Vinyl Compounds / Q000506:poisoning*
D000085:Acetates; D014753:Vinyl Compounds; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase
Izmenenie ritma fermentativnoĭ aktivnosti pecheni u belykh krys pri khronicheskom deĭstvii vinilatsetata