Quantitative assay of maprotiline in biological fluids by gas-liquid chromatography.
A specific and sensitive gas-liquid chromatographic method has been developed for the assay of maprotiline in biological fluids. Maprotiline is isolated from the biological sample by base-specific extraction followed by conversion into the heptafluorobutyramide. The derivative is determined quantitatively by gas-liquid chromatography with an electron capture detector, nortriptyline being used as the internal standard. Amounts below 10 ng per biological sample can be measured.
D000873:Anthracenes / Q000032:analysis*; D002849:Chromatography, Gas; D004583:Electrons; D005069:Evaluation Studies as Topic; D006801:Humans; D008376:Maprotiline / Q000032:analysis* / Q000097:blood / Q000652:urine; D008722:Methods
D000873:Anthracenes; D008376:Maprotiline