Cholinergic modulation of an opposed effect of d-amphetamine and methylphenidate on the rearing response.
Rats given d-amphetamine (1 mg/kg) engage in frequent, short-duration rearing responses, whereas rats given methylphenidate (1 mg/kg) make less frequent, long-duration responses. The effects on this behavior of mixing d-amphetamine or methylphenidate with scopolamine or physostigmine suggest that this opposed action on rearing response duration is related to cholinergic-catecholaminergic balance. The anticholinergic agent scopolamine produces changes in rearing response duration similar to those produced by d-amphetamine, while the cholinergic agent physostigmine lengthens response duration and further potentiates this effect of methylphenidate.
D000818:Animals; D001288:Attention / Q000187:drug effects* / Q000502:physiology; D003913:Dextroamphetamine / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D004357:Drug Synergism; D005260:Female; D006185:Habituation, Psychophysiologic / Q000187:drug effects; D008774:Methylphenidate / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D010275:Parasympathetic Nervous System / Q000502:physiology*; D010830:Physostigmine / Q000494:pharmacology; D011187:Posture; D051381:Rats; D011930:Reaction Time / Q000187:drug effects; D012601:Scopolamine / Q000494:pharmacology
D008774:Methylphenidate; D010830:Physostigmine; D012601:Scopolamine; D003913:Dextroamphetamine