Antitussive drugs. II. Bronchopulmonary effects of dextromethorphan and doxylamine.
Unlike codeine, dextromethorphan does not cause pulmonary vasoconstiction in the anesthetized dog. The other effects of dextromethorphan are as follwos: a rise in pulmonary resistance indicating bronchoconstriction, and increase in pulmonary blood flow relating to a positive inotropic action, and a decrease in aortic blood pressure resulting from systemic vasodilation. These effects are blocked by previous injections of doxylamine, an antihistaminic drug. This interaction suggests a rationale for the combined use of dextromethorphan and doxylamine in the treatment of upper respiratory infection.
D000403:Airway Resistance / Q000187:drug effects; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D001980:Bronchi / Q000187:drug effects*; D003915:Dextromethorphan / Q000494:pharmacology; D004285:Dogs; D004319:Doxylamine / Q000494:pharmacology*; D004347:Drug Interactions; D006339:Heart Rate / Q000187:drug effects; D007981:Levorphanol / Q000031:analogs & derivatives*; D008168:Lung / Q000187:drug effects*; D008170:Lung Compliance / Q000187:drug effects; D011652:Pulmonary Circulation / Q000187:drug effects; D011725:Pyridines / Q000494:pharmacology*; D014655:Vascular Resistance / Q000187:drug effects
D011725:Pyridines; D007981:Levorphanol; D003915:Dextromethorphan; D004319:Doxylamine