Suppression of lymphocyte transformation by 16, (16) dimethyl prostaglandin E2 and unsaturated fatty acids.
A new synthetic prostaglandin (16, 16-PGE2) and unsaturated fatty acids have been shown to inhibit the incorporation of [3H]thymidine in the lymphocyte transformation reaction in response to phytohemagglutinin (PHA). This inhibition was not due to toxicity of these substances, for the lymphocytes remained intact and capable of excluding trypan blue.
D000328:Adult; D001095:Arachidonic Acids / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D005231:Fatty Acids, Unsaturated / Q000494:pharmacology*; D006801:Humans; D008041:Linoleic Acids / Q000494:pharmacology; D008213:Lymphocyte Activation / Q000187:drug effects*; D009829:Oleic Acids / Q000494:pharmacology; D011458:Prostaglandins E / Q000494:pharmacology*
D001095:Arachidonic Acids; D005231:Fatty Acids, Unsaturated; D008041:Linoleic Acids; D009829:Oleic Acids; D011458:Prostaglandins E