Contrast and electrolyte dynamics of the intravenous pyelogram. II. Disparities in serum and urine concentrations of meglumine and anion.
Intravenous or intra-aortic injections of meglumine iothalamate in dogs indicate a slightly different tissue distribution and excretory pattern of the meglumine cation and the iothalamate anion. Differences in serum and urinary concentrations of these ions suggest some cellular penetration of the meglumine anion. In addition, there seems to be some evidence for both tubular absorption and tubular excretion of meglumine as a minor component in the renal excretion of this ion. No significant differences could be demonstrated for either urinary load or concentration when the sodium salts of iothalamate were compared to the methylglucamine salts.
D000818:Animals; D000838:Anions; D001012:Aorta, Abdominal; D004285:Dogs; D005260:Female; D005919:Glomerular Filtration Rate / Q000187:drug effects; D007269:Injections, Intra-Arterial; D007275:Injections, Intravenous; D007482:Iothalamate Meglumine / Q000008:administration & dosage / Q000378:metabolism*; D007483:Iothalamic Acid / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000378:metabolism; D007668:Kidney / Q000378:metabolism*; D008297:Male; D013997:Time Factors; D014567:Urography
D000838:Anions; D007483:Iothalamic Acid; D007482:Iothalamate Meglumine