The photocarcinogenicity of anthracence: photochemical binding to deoxyribonucleic acid in tissue culture.
Anthracene becomes covalently bound to high-molecular-weight DNA in mammalian tissue culture as a result of irradiation at 365 nm after the incubation of cells with the hydrocarbon. At high radiation doses, the extent of binding exceeds one hydrocarbon molecule per 10(3) bases, and is lethal. At low radiation doses, much decreased binding is observed, but a majority of cells remain viable and can be recultured.
D000873:Anthracenes / Q000494:pharmacology; D001665:Binding Sites; D002460:Cell Line; D002499:Centrifugation, Density Gradient; D002850:Chromatography, Gel; D004247:DNA / Q000378:metabolism; D008027:Light; D010777:Photochemistry
D000873:Anthracenes; D004247:DNA