New 2-methyldialkylammoniumalkylthio-4,p-substituted phenyl-3H-1,5-benzodiazepine iodides with antibacterial activity note I.
A series of 2-methyldialkylammoniumalkylthio-4,p-substituted phenyl-3H-1,5-benzodiazepine iodides has been synthesized. Some compounds showed high selective activity against Staph. aureus and Strep. pyogenes. The nature of the sustituents at the phenyl moiety bound to the 4-position of the 1,5-benzodiazepine ring is of decisive influence, wherease the length of the aliphatic chain and the modification of the cationic head are of minor importance for the activity. The most active compound, 2-methyldiethylammoniumethylthio-4,p-phenylthiophenyl-3H-1,5-benzodiazepine iodide (XXXVIII), was selected for further research.
D001419:Bacteria / Q000187:drug effects*; D001569:Benzodiazepines / Q000494:pharmacology*; D055598:Chemical Phenomena; D002621:Chemistry; D004353:Drug Evaluation, Preclinical; D008826:Microbial Sensitivity Tests; D000644:Quaternary Ammonium Compounds / Q000494:pharmacology
D000644:Quaternary Ammonium Compounds; D001569:Benzodiazepines