Concentrations of some metabolites in the aqueous humour of human senile cataractous eyes.
Glucose, pyruvate, l-lactate, and citrate concentrations of the aqueous humour were examined in 51 patients aged 54-87 years with senile cataracts, and in one patient with a clear lens. Furthermore, the ratios of glucose in aqueous/glucose in plasma and citrate in aqueous/citrate in plasma were investigated. Among the parameters recorded, age dependence could only be demonstrated for glucose concentrations in the aqueous humour, as this parameter decreases with increasing age. However, a chance significance because of multipleignificance tests cannot be left out of account in this material. The parameters in question are unfit for an evaluation of possible changes in the energy metabolism of the lens in relation to cataract development because no significant differences were found between concentrations and ratios in different clinical types of cataract. Also, considerable ranges of variation were recorded.
D000367:Age Factors; D000368:Aged; D001082:Aqueous Humor / Q000378:metabolism*; D001786:Blood Glucose / Q000378:metabolism; D002386:Cataract / Q000097:blood / Q000378:metabolism*; D002951:Citrates / Q000097:blood / Q000378:metabolism*; D004734:Energy Metabolism; D005260:Female; D005947:Glucose / Q000378:metabolism*; D006801:Humans; D007773:Lactates / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D011773:Pyruvates / Q000378:metabolism*
D001786:Blood Glucose; D002951:Citrates; D007773:Lactates; D011773:Pyruvates; D005947:Glucose