Transcallosal effects of a cortical epileptiform focus.
Unit activity in anesthetized cats was studied in cortical regions contralateral to the site of an acute epileptiform focus. Orthodromic effects of transcallosal discharge varied in extracellular records; however, in intracellular records, most cells displayed an EPSP-IPSP sequence. In a small proportion of cells, antidromic activation was also observed. The significance of this 'backfiring' phenomenon, and some factors possibly involved in generation of 'backfiring' activity, are discussed.
D000818:Animals; D002415:Cats; D002540:Cerebral Cortex / Q000503:physiopathology; D003337:Corpus Callosum / Q000503:physiopathology*; D005071:Evoked Potentials; D009433:Neural Inhibition; D012640:Seizures / Q000503:physiopathology*; D013787:Thalamic Nuclei / Q000503:physiopathology