Mast cell and anaphylactic antibody responses in inbred rats to syngeneic fibrosarcomas.
The mast cell content of sarcomata induced chemically in inbred rats showed wide variation. After first passage into a normal syngeneic recipient, primary tumours which were heavily infiltrated showed a complete absence of mast cells. Moreover, detectable anaphylactic antibody to passaged tumours was only occasionally detected. An important immunological role for the IgE/mast cell system in host-tumour defence is not supported.
D000707:Anaphylaxis / Q000276:immunology*; D000818:Animals; D000917:Antibody Formation; D005354:Fibrosarcoma / Q000139:chemically induced / Q000276:immunology*; D008297:Male; D008407:Mast Cells / Q000276:immunology* / Q000473:pathology; D008748:Methylcholanthrene; D009374:Neoplasms, Experimental / Q000139:chemically induced / Q000276:immunology; D051381:Rats; D011919:Rats, Inbred Strains
D008748:Methylcholanthrene