Idiopathic hypertrophic subaortic stenosis presenting as cough syncope.
In a patient with idiopathic hypertrophic subaortic stenosis, syncope developed as a result of a sustained decrease in aortic pressure induced by severe cough paroxysms. Treatment with propranolol was effective in abolishing the syncopal episodes, by reducing the post-tussive gradient and facilitating a more rapid return to normal of aortic pressure. Post-tussive syncope in IHSS may result from both an unusually strong cough paroxysm and augmented left ventricular outflow obstruction consequent to reflex sympathetic stimulation.
D002312:Cardiomyopathy, Hypertrophic / Q000150:complications* / Q000175:diagnosis; D003371:Cough / Q000150:complications* / Q000188:drug therapy; D006801:Humans; D006973:Hypertension / Q000175:diagnosis; D008297:Male; D008875:Middle Aged; D011433:Propranolol / Q000627:therapeutic use; D013575:Syncope / Q000209:etiology*
D011433:Propranolol