[Behavior of the immunoglobin level in the serum of patients with ovarian neoplasms].
In 18 patients with the histological proved Ca ovarii we have examined the level of serum immunoglobulins IgG, IgA and IgM in blood during the combined therapy by two cytostatics (Cyclophosphamide, Cytembena) in a week's intervals. The serum immunoglobins IgG, IgA, IgM was followed by the simple radial immunodiffusion technic by Manchini in 2% agar gel with the standard fa Sevac (CSSR). The level of IgG sank at least 10% in 10 patients, the level of IgA and IgG in 9 patients. We have also followed every month the level of the serum immunoglobins at the long times administration of several peroral doses of Cyclophosphamid in 9 patients. At this long times administration the serum immunoglobins IgG and IgA were found responsible in their reduced synthesis than the IgM.
D000179:Acrylates / Q000627:therapeutic use; D000368:Aged; D000840:Anisoles / Q000627:therapeutic use; D001966:Bromine / Q000627:therapeutic use; D003520:Cyclophosphamide / Q000627:therapeutic use; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D007070:Immunoglobulin A / Q000032:analysis; D007074:Immunoglobulin G / Q000032:analysis; D007075:Immunoglobulin M / Q000032:analysis; D007136:Immunoglobulins / Q000032:analysis*; D007659:Ketones / Q000627:therapeutic use; D008875:Middle Aged; D010051:Ovarian Neoplasms / Q000188:drug therapy / Q000276:immunology*
D000179:Acrylates; D000840:Anisoles; D007070:Immunoglobulin A; D007074:Immunoglobulin G; D007075:Immunoglobulin M; D007136:Immunoglobulins; D007659:Ketones; D003520:Cyclophosphamide; D001966:Bromine
Verhalten des Immunglobulinspiegels im Blutserum bei Patientinnen mit Carcinoma ovarii