[Effect of immunoglobulin G in the blood serum from cancer patients on glycolysis].
The activity of reconstructed glyceraldehyde phosphate dehydrogenase and lactate dehydrogenase reactions was studied as affected by immunoglobulin G of blood serum from patients with cancer and protein positively reacting in sedimentation test for cancer which is one of its subfractions. Addition of the protein under study to the sample is shown to inhibit the glyceraldehyde phosphate dehydrogenase reaction but activates the lactate dehydrogenase one. On the basis of the data obtained a conclusion is made that the effect of immunoglobulins G in the glycolytic systems is connected with the reactions of hydrogen transfer.
D004789:Enzyme Activation / Q000187:drug effects; D005987:Glyceraldehyde-3-Phosphate Dehydrogenases / Q000037:antagonists & inhibitors; D006019:Glycolysis / Q000187:drug effects*; D006801:Humans; D007074:Immunoglobulin G; D007770:L-Lactate Dehydrogenase / Q000378:metabolism; D009369:Neoplasms / Q000276:immunology*
D007074:Immunoglobulin G; D007770:L-Lactate Dehydrogenase; D005987:Glyceraldehyde-3-Phosphate Dehydrogenases
Vpliv na glikoliz imunoglobulinu G sirovatki krovi khvorikh na rak