[Tryptophan metabolism research in oligophrenic children. 4.: Activity and possibility of activating hepatic kynureninase after vitamin B6 treatment].
In 8 selected test persons of the 3rd series of experiments who were showing signs of pathological kynureninase activity, hepatic kynureninase was again established after 3 week's treatment with large doses of vitamin B6. The enormous in-vivo activation of the kynureninasis established goes to prove that apoenzyme synthesis may be stimulated by pyridoxine. On the basis of these results and the relative frequency of disorders dependent on B6, the question arises whether children from endangered families should not be given prophylactic vitamin B6 treatment from birth.
D000293:Adolescent; D002648:Child; D004789:Enzyme Activation / Q000187:drug effects; D006801:Humans; D006867:Hydrolases / Q000378:metabolism*; D008607:Intellectual Disability / Q000188:drug therapy* / Q000378:metabolism / Q000517:prevention & control; D008099:Liver / Q000187:drug effects; D011736:Pyridoxine / Q000008:administration & dosage / Q000627:therapeutic use*; D014364:Tryptophan / Q000378:metabolism*
D014364:Tryptophan; D006867:Hydrolases; D011736:Pyridoxine
Tryptophanstoffwechseluntersuchungen bei oligophrenen Kindern. 4. Mitteilung: Aktivität und Aktivierbarkeit der hepatischen Kynureninase nach Vitamin B6-Behandlung