[Deiodination in the kidney and thyroid function)].
In homogenate supernatants of kidneys of male rats the extent of deiodination of L-diiodotyrosine (L-DJT) and L-thyroxine (L-T4) was investigated in dependence on the thyroid function (hypo- and hyperthyroidized) and also in dependence on age. In rats hypothyroidized by loading with Methylthiouracil (MTU) or Methimazol (MMI) the deiodination for L-DJT and L-T4 was significantly reduced, in rats loaded with 40 mug T4 sc. for 10 days, the deiodination was significantly enhanced compared with untreated control animals. With advancing age (6 weeks, 3 or 12 month) the deiodination activity is highly significantly reduced. The results underline relations between thyroid gland function and deiodination activity in kidney.
D000367:Age Factors; D000818:Animals; D004105:Diiodotyrosine / Q000378:metabolism; D006980:Hyperthyroidism / Q000378:metabolism; D007037:Hypothyroidism / Q000378:metabolism; D007455:Iodine / Q000378:metabolism*; D007668:Kidney / Q000378:metabolism*; D008297:Male; D008713:Methimazole / Q000494:pharmacology; D008779:Methylthiouracil / Q000494:pharmacology; D007470:Monoiodotyrosine / Q000096:biosynthesis; D051381:Rats; D013959:Thyroid Diseases / Q000378:metabolism*; D013963:Thyroid Hormones / Q000378:metabolism*; D013974:Thyroxine / Q000378:metabolism / Q000494:pharmacology; D014284:Triiodothyronine / Q000096:biosynthesis
D013963:Thyroid Hormones; D014284:Triiodothyronine; D008713:Methimazole; D004105:Diiodotyrosine; D007455:Iodine; D007470:Monoiodotyrosine; D013974:Thyroxine; D008779:Methylthiouracil
Dejodierung in der Niere und Schilddrüsenfunktion