A study on the biochemical genetics of abnormal hemoglobins.
In recent years, there were found in China 2 kinds of hemoglobin-M (Hb M Shanghai-1, Hb M Shanghai-2) and 2 kinds of unstable hemoglobin (Hb Shanghai-1, Hb Shanghai-2), amoung which the propositus of Hb Shanghai-2 proved to be a heterozygote for both unstable hemoglobin gene and beta-thalassaemia gene. This article gives an account of the biochemical analysis and genetic studies of these four kinds of abnormal homoglobins. Besides, we present here also the records of 2 family pedigrees of alpha-thalassaemia, and found in the blood of a patient a small quantity of another abnormal hemoglobin constituent in addition to Bart's hemoglobin and hemoglobin H. On these bases, a new hypothesis concerning the heredity of alpha-thalassaemia disease is proposed.
D000328:Adult; D002648:Child; D002681:China; D003490:Cyanosis / Q000097:blood / Q000235:genetics; D005260:Female; D005796:Genes; D006447:Hemoglobin H / Q000032:analysis; D006455:Hemoglobins, Abnormal / Q000032:analysis*; D006801:Humans; D007223:Infant; D008297:Male; D008706:Methemoglobin / Q000032:analysis; D010375:Pedigree; D010446:Peptide Fragments / Q000032:analysis; D013789:Thalassemia / Q000097:blood / Q000235:genetics*
D006455:Hemoglobins, Abnormal; D010446:Peptide Fragments; D008706:Methemoglobin; D006447:Hemoglobin H