Growth in experimental renal failure: role of calorie and amino acid intake.
In order to evaluate the role of calorie and protein intake in growth impairment due to chronic renal failure (CRF), a subtotal nephrectomy was performed in weanling Wistar rats. A two-thirds reduction of renal function was obtained, which induced a marked growth retardation. Growth retardation was identical in nephrectomized and in pair-fed controls, and thus appeared to be entirely due to a deficient food intake. Using low protein diets, administration of a supplement with small amounts of essential amino acids (EAA) resulted in accelerated growth associated with a higher calorie intake, a better utilization of ingested calories for growth and a greater fall of blood urea nitrogen concentration.
D000601:Amino Acids, Essential / Q000378:metabolism*; D000824:Animal Nutritional Physiological Phenomena; D000818:Animals; D001827:Body Height; D001835:Body Weight; D004044:Dietary Proteins / Q000378:metabolism*; D004435:Eating; D005919:Glomerular Filtration Rate; D006128:Growth; D007668:Kidney / Q000503:physiopathology; D007676:Kidney Failure, Chronic / Q000378:metabolism / Q000503:physiopathology*; D008297:Male; D009392:Nephrectomy; D051381:Rats; D013977:Tibia / Q000473:pathology
D000601:Amino Acids, Essential; D004044:Dietary Proteins