[Study of the ultrastructural and functional expression of the hepatocyte genome under conditions of prolonged depression of protein biosynthesis by cycloheximide. III].
Dynamics of changes in mtRNA synthesis and mitochondria ultrastructure is strictly dependent on the level of inhibition of biosynthesis of cytoplasm proteins and "soluble" proteins of mitochondria by cycloheximide in hepatocytes: 1-6 hrs later a progressive weakening of protein synthesis is accompanied by a drop in mtRNA synthesis and essential destruction of mitochondria; from 12 to 24 hrs a partial restoration of protein biosynthesis induces the processes of the above-mentioned indexes normalization.
D000818:Animals; D003513:Cycloheximide / Q000494:pharmacology*; D003593:Cytoplasm / Q000187:drug effects / Q000378:metabolism; D005838:Genotype; D008099:Liver / Q000648:ultrastructure*; D008297:Male; D008930:Mitochondria, Liver / Q000187:drug effects / Q000378:metabolism / Q000648:ultrastructure; D014176:Protein Biosynthesis; D012333:RNA, Messenger / Q000096:biosynthesis*; D012343:RNA, Transfer / Q000096:biosynthesis*; D051381:Rats; D013997:Time Factors
D012333:RNA, Messenger; D012343:RNA, Transfer; D003513:Cycloheximide
Issledovanie ul'trastrukturnogo i funktsional'nogo vyrazheniia genoma gepatotsitov v usloviiakh prodolzhitel'nogo ugneteniia biosinteza belka tsiklogeksimidom. Soobshchenie III