[Effect of anoxia on the excitability of the canine ventricular muscle (author's transl)].
It has been believed that completion of refractory period does coincide with full repolarization in cardiac muscle. So, the duration of action potensial (APD) has not infrequently been derived from refractory period. But recently some authors pointed out that duration of total refractory period (TRP) was not identical with APD in anoxic state and prolonged severe anoxia might occasionally increase effective refractory period (ERP). Nevertheless, marked reduction has been consistently noted in APD by many workers during severe anoxic period. Then, it seems to deserve more detailed investigation whether the refractory period may represent APD under any condition. The purpose of this paper is to present the results of studies on the effects of anoxia on the relationship between refractoriness and transmembrane action potential.
D000200:Action Potentials; D000818:Animals; D004285:Dogs; D006321:Heart / Q000502:physiology*; D006352:Heart Ventricles; D066298:In Vitro Techniques; D009206:Myocardium / Q000378:metabolism; D009431:Neural Conduction; D010101:Oxygen Consumption; D012032:Refractory Period, Electrophysiological