Experimental studies on the effects of aluminum on pregnancy and fetal development.
The effects of aluminum on pregnancy and fetal development were investigated. Aluminum in the form of aluminum chloride was administered intraperitoneally to pregnant rats at different dose-levels and at different stages of gestation. A high incidence of maternal death followed treatment with high dose-levels of the substance. Maternal weight gain during the entire gestational period was less in treated animals, compared to controls. In many cases, maternal liver was severely damaged as a result of the treatment. The offspring of mothers treated with aluminum chloride showed significant growth retardation as well as skeletal defects. In addition the incidence of fetal deaths and resorption was significantly increased.
D000014:Abnormalities, Drug-Induced; D000535:Aluminum / Q000494:pharmacology*; D000818:Animals; D001835:Body Weight / Q000187:drug effects; D001846:Bone Development / Q000187:drug effects; D001842:Bone and Bones / Q000002:abnormalities; D056486:Chemical and Drug Induced Liver Injury; D004305:Dose-Response Relationship, Drug; D005260:Female; D005313:Fetal Death / Q000139:chemically induced; D005327:Fetal Resorption / Q000139:chemically induced; D005333:Fetus / Q000187:drug effects*; D005865:Gestational Age; D011247:Pregnancy; D011248:Pregnancy Complications / Q000139:chemically induced; D011270:Pregnancy, Animal / Q000187:drug effects*; D051381:Rats
D000535:Aluminum