Caffeine inhibition of the repair of ultraviolet-irradiated adenovirus in human cells.
Caffeine is shown to block repair of ultraviolet-irradiated adenovirus 2 when the irradiated virus infects normal human fibroblasts from a xeroderma pigmentosum (XP) variant. Such blockage is not observed when the irradiated virus infects XP fibroblasts belonging to XP complementation group A. Thus normal and XP variant cells have a caffeine-sensitive repair process. This may be either excision or an excision dependent repair process because fibroblasts belonging to XP complementation group A are believed to lack the excision repair process.
D000256:Adenoviridae / Q000528:radiation effects*; D002110:Caffeine / Q000494:pharmacology*; D004260:DNA Repair; D004279:DNA, Viral; D005347:Fibroblasts / Q000378:metabolism; D006801:Humans; D011831:Radiation Genetics; D014466:Ultraviolet Rays; D014983:Xeroderma Pigmentosum / Q000378:metabolism
D004279:DNA, Viral; D002110:Caffeine