[Influence of low doses of a heparin-urea complex on the aggregation of thrombocytes and the fibrinolytic activity of blood in intravenous infusion and in in vitro experiments].
An addition in in vitro experiments of a heparin-urea (HU) complex to a thrombocyte rich plasma completely blocked the onset of the thrombocytes aggregation, induced by thrombin, and reduced the degree of aggregation caused by adenosine-diphosphate. An intravenous administration of a 0.01% HU complex solution to rats 5 minutes after injection also blocked the thrombocytes aggregation induced by thrombin. The effect of the HU complex on the thromocytes aggregation proceeded against the background of a significantly delayed blood clotting time and an activation of of a fermentative and non-fermentative fibrinolysis, emerging after introduction of the heparin-urea complex.
D000244:Adenosine Diphosphate / Q000037:antagonists & inhibitors; D000818:Animals; D005342:Fibrinolysis / Q000187:drug effects*; D006493:Heparin / Q000494:pharmacology*; D066298:In Vitro Techniques; D010974:Platelet Aggregation / Q000187:drug effects*; D051381:Rats; D013917:Thrombin / Q000037:antagonists & inhibitors; D014508:Urea / Q000494:pharmacology*
D000244:Adenosine Diphosphate; D014508:Urea; D006493:Heparin; D013917:Thrombin
Vliianie malykh doz kompleksa geparin-mochevina na agregatsiiu trombotsitov i fibrinoliticheskuiu aktivnost' krovi pri vnutrivennom vlivanii i v opytakh in vitro