[Ultrastructure of the prolactin cells of the pituitary gland of female rats after stimulation with norethisterone enanthate].
Prolactine cells of rat anterior pituitary gland were studied with the electron microscope in thin sections and freeze-etch replicas after treatment with norethisterone-oenanthate. A pathological secretory process is caused in this cell type in rats, when treated with this compound. Prolactine cells grow in number and volume of single cells. This is especially due to an enormous proliferation of the Golgi apparatus. In the same time, however, exocytosis of hormonal secretory granules is apparently reduced. Therefore, serum hormone level remains nearly normal.
D000818:Animals; D005260:Female; D009640:Norethindrone / Q000494:pharmacology*; D010902:Pituitary Gland / Q000166:cytology*; D010903:Pituitary Gland, Anterior / Q000166:cytology* / Q000187:drug effects; D011388:Prolactin / Q000096:biosynthesis*; D051381:Rats
D011388:Prolactin; D009640:Norethindrone
Ultrastructure des cellules à prolactine de l'hypophyse de ratte après stimulation par l'énanthate de norethisterone