The effect of adrenergic blocking drugs on outflow resistance.
Alpha blockade at a dose which produces minimal cardiovascular effects causes a significant fall in the urethral pressure profile in man. No change in profile height has been seen following the administration of a beta blocking drug in a dose producing cardiovascular changes of a similar order of magnitude.
D000328:Adult; D000368:Aged; D001794:Blood Pressure / Q000187:drug effects; D005260:Female; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D008297:Male; D008875:Middle Aged; D010646:Phentolamine / Q000494:pharmacology*; D011312:Pressure; D011433:Propranolol / Q000494:pharmacology*; D014521:Urethra / Q000502:physiology; D014551:Urinary Tract / Q000187:drug effects*; D014554:Urination / Q000187:drug effects*
D011433:Propranolol; D010646:Phentolamine