Central nervous system pharmacology of propranolol.
In rats, propranolol potentiated alcohol and pentobarbitone hypnosis, but not barbital sleeping time, indicating enzyme inhibition as a possible mechanism of potentiation. Propranolol showed anticonvulsant effect on normal and reserpine treated rats by MES test, but showed dose related lowering of MET. Probable mechanisms are discussed.
D000818:Animals; D001462:Barbital / Q000494:pharmacology; D001923:Brain Chemistry / Q000187:drug effects; D004357:Drug Synergism; D004597:Electroshock; D000431:Ethanol / Q000494:pharmacology; D008297:Male; D010424:Pentobarbital / Q000494:pharmacology; D010643:Phenoxybenzamine / Q000494:pharmacology; D011433:Propranolol / Q000494:pharmacology* / Q000627:therapeutic use; D051381:Rats; D012110:Reserpine / Q000037:antagonists & inhibitors; D012640:Seizures / Q000517:prevention & control*; D012701:Serotonin / Q000032:analysis; D012890:Sleep / Q000187:drug effects*
D010643:Phenoxybenzamine; D012701:Serotonin; D000431:Ethanol; D001462:Barbital; D012110:Reserpine; D011433:Propranolol; D010424:Pentobarbital