Gangliosides of the human gastrointestinal mucosa.
Gangliosides of the human alimentary mucosa were purified and analysed with thin-layer chromatography and gas chromatography. The content of ganglioside neuraminic acid was 0.16 mumol/g dry weight in the stomach, 0.07 mumol/g dry weight in the small intestine and 0.11 mumol/g dry weight in the large intestine. Mono- and disialosylhemosides were the major gangliosides, on a molar basis 68% of the total found in the stomach and 44% of the total in the small and large intestine. Considerable amounts of more complex gangliosides were found, especially in the small and large intestine, in which the molar content of tri- and tetraglycosylgangliosides containing galactosamine made up 38% of the total. Two glucosamine-containing gangliosides were also found, the probable structures of which were mono- and disialotetraglycosylceramide. The presence of the latter is reported for the first time.
D002554:Cerebrosides / Q000032:analysis; D004064:Digestive System / Q000032:analysis*; D005688:Galactosamine / Q000032:analysis; D005732:Gangliosides / Q000032:analysis*; D005753:Gastric Mucosa / Q000032:analysis; D005944:Glucosamine / Q000032:analysis; D006801:Humans; D007413:Intestinal Mucosa / Q000032:analysis; D007420:Intestine, Large / Q000032:analysis; D007421:Intestine, Small / Q000032:analysis; D009438:Neuraminic Acids / Q000032:analysis; D013270:Stomach / Q000032:analysis
D002554:Cerebrosides; D005732:Gangliosides; D009438:Neuraminic Acids; D005688:Galactosamine; D005944:Glucosamine