Effects of ketamine on central sympathetic discharge and the baroreceptor reflex during mechanical ventilation.
In rabbits which were ventilated mechanically, with a background anaesthetic of pentobarbitone or after decerebration, ketamine depressed preganglionic sympathetic activity and arterial pressure. Conduction through central baroreceptor pathways, tested by depressor nerve stimulation, showed a selective inhibition of the heart rate response.
D000818:Animals; D001011:Aorta / Q000294:innervation; D001339:Autonomic Fibers, Preganglionic / Q000187:drug effects; D001794:Blood Pressure / Q000187:drug effects; D003864:Depression, Chemical; D004305:Dose-Response Relationship, Drug; D004558:Electric Stimulation; D006339:Heart Rate / Q000187:drug effects; D007649:Ketamine / Q000494:pharmacology*; D008297:Male; D010424:Pentobarbital / Q000008:administration & dosage; D011311:Pressoreceptors / Q000187:drug effects*; D011817:Rabbits; D012018:Reflex / Q000187:drug effects; D012121:Respiration, Artificial; D013564:Sympathetic Nervous System / Q000187:drug effects*; D013997:Time Factors; D014630:Vagus Nerve / Q000502:physiology
D007649:Ketamine; D010424:Pentobarbital