Effect of catecholamines on renin release in vitro.
Beta receptor activation by isoproterenol stimulates renin release by kidney slices "in vitro". This effect is dose-dependent and blocked by propranolol. High norepinephrine concentration has an inhibitory effect on renin secretion which is reversed by phentolamine: activation of alpha receptors probably decreases renin release.
D000818:Animals; D002395:Catecholamines / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D004336:Drug Antagonism; D066298:In Vitro Techniques; D007545:Isoproterenol / Q000494:pharmacology; D007668:Kidney / Q000187:drug effects* / Q000378:metabolism; D008297:Male; D009638:Norepinephrine / Q000494:pharmacology; D010646:Phentolamine / Q000494:pharmacology; D011433:Propranolol / Q000494:pharmacology; D051381:Rats; D011941:Receptors, Adrenergic / Q000187:drug effects; D012083:Renin / Q000378:metabolism*
D002395:Catecholamines; D011941:Receptors, Adrenergic; D011433:Propranolol; D012083:Renin; D007545:Isoproterenol; D009638:Norepinephrine; D010646:Phentolamine