title: Folate metabolism in the rat liver during regeneration after partial hepatectomy.
abstract: 1. Folate metabolism was studied during the early phases of liver regeneration after partial hepatectomy in rats accustomed to eating during the first 8h of a daily 12h dark period. 2. The content of 5-CH(3)-H(4)folate was drastically decreased during the first hours of regeneration. 3. The total HCO-H(4)folate coenzymes showed a constant decrease during the first 3 days of regeneration, and a continuous interconversion between 5-HCO-H(4)folate and 10-HCO-H(4)folate. 4. 10-HCO-H(4)folate synthetase, serine hydroxymethyl-transferase and 5,10-CH(2)-H(4)folate dehydrogenase activities were relatively low during the first hours after the operation, and increased only several hours later. 5. The increase in enzyme activities showed a stepwise pattern, apparently due to an interaction between the regeneration process and the controlled feeding schedules.
mesh_terms: D000818:Animals; D003067:Coenzymes / Q000096:biosynthesis; D005492:Folic Acid / Q000031:analogs & derivatives / Q000378:metabolism*; D005574:Formate-Tetrahydrofolate Ligase / Q000378:metabolism; D005575:Formyltetrahydrofolates / Q000378:metabolism; D012696:Glycine Hydroxymethyltransferase / Q000378:metabolism; D006498:Hepatectomy; D008099:Liver / Q000201:enzymology / Q000378:metabolism*; D008115:Liver Regeneration; D008297:Male; D008754:Methylenetetrahydrofolate Dehydrogenase (NADP) / Q000378:metabolism; D051381:Rats; D013762:Tetrahydrofolate Dehydrogenase / Q000378:metabolism
chemical_list: D003067:Coenzymes; D005575:Formyltetrahydrofolates; D005492:Folic Acid; D013762:Tetrahydrofolate Dehydrogenase; D008754:Methylenetetrahydrofolate Dehydrogenase (NADP); D012696:Glycine Hydroxymethyltransferase; D005574:Formate-Tetrahydrofolate Ligase