[Oncobiograms and cancer chemotherapy: Hope or reality? (author's transl)].
On the basis of animal experiments it is shown that the results of tumor chemotherapy can be predicted with the aid of in-vitro test systems. In investigations carried out on human tumors, the correlations obtained between in-vitro test results and response to therapy are promising. However, definitive proof of a correlation can only be provided by planned, statistically supported clinical studies. Two types of information can already be obtained from the in-vitro tests: data concerning the rate of proliferation of the tumor, on which the activity of cytostatic agents depends, and data on certain types of resistance to cytostatics.
D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology* / Q000627:therapeutic use*; D002279:Carcinoma 256, Walker / Q000188:drug therapy; D002455:Cell Division / Q000187:drug effects; D002478:Cells, Cultured / Q000187:drug effects*; D006224:Cricetinae; D004273:DNA, Neoplasm / Q000096:biosynthesis; D004317:Doxorubicin / Q000627:therapeutic use; D066298:In Vitro Techniques; D008545:Melanoma / Q000188:drug therapy; D051379:Mice; D010954:Plasmacytoma / Q000188:drug therapy; D012334:RNA, Neoplasm / Q000096:biosynthesis; D051381:Rats; D012510:Sarcoma 180 / Q000188:drug therapy
D000970:Antineoplastic Agents; D004273:DNA, Neoplasm; D012334:RNA, Neoplasm; D004317:Doxorubicin
Onkobiogramm und Krebs-Chemotherapie: realität oder hoffnung