title: Severe hypertension in chronic renal failure treated successfully with Minoxidil.
abstract: In fifteen patients with severe hypertension, eight of whom had end-stage kidney disease, blood pressure could not be adequately controlled with conventional oral antihypertensive drugs. Minoxidil, an orally administered drug which lowers blood pressure by reducing total peripheral resistance, produced a substantial reduction in blood pressure in all patients who were treated, including patients who prior to its availiability would have been considered for bilateral nephrectomy.
mesh_terms: D000328:Adult; D002648:Child; D005260:Female; D006801:Humans; D006977:Hypertension, Renal / Q000188:drug therapy* / Q000209:etiology; D007676:Kidney Failure, Chronic / Q000150:complications*; D008297:Male; D008875:Middle Aged; D008914:Minoxidil / Q000627:therapeutic use*; D011743:Pyrimidines / Q000627:therapeutic use*
chemical_list: D011743:Pyrimidines; D008914:Minoxidil