[Influence of diazepam and triftazine on the blood supply and the activity of the heart].
In experiments with urethan and chloralose anesthetized cats it was found that diazepam (0.15 and 0.5 mg/kg) and trifazine (0.25 and 1 mg/kg), when administered intravenously, produce hypotension, depress the tonicity of the coronary and renal vessels. Under the effect of diazepam there develops bradycardia, the maximal acceleration of the blood flow in the aorta and the cardiac ejection decrease, the systol period gets longer, the coronary circulation rate and the oxygen uptake by the heart go down. Triftazine, on the contrary, augments the blood outflow from the coronary sinus and the oxygen uptake by the myocardium. In the course of 5-10 minutes following introduction thereof it produces tachycardia, intensifies the contractility of the myocardium and the cardiac ejection.
D000818:Animals; D001783:Blood Flow Velocity; D001794:Blood Pressure / Q000187:drug effects; D002415:Cats; D003331:Coronary Vessels / Q000187:drug effects*; D003975:Diazepam / Q000494:pharmacology*; D006321:Heart / Q000187:drug effects*; D006339:Heart Rate / Q000187:drug effects; D007668:Kidney / Q000098:blood supply; D010101:Oxygen Consumption; D014268:Trifluoperazine / Q000494:pharmacology*; D014655:Vascular Resistance
D014268:Trifluoperazine; D003975:Diazepam
Vliianie diazepama i triftazina na krovosnabzhenie i deiatel'nost' serdtsa