title: New derivatives of 2-carboxychromanone-4 as potential antiinflammatory drugs. I. Cis-and trans-beta-2,4-dihydroxybenzoylacrylic acids and their derivatives.
abstract: Proof is presented that the product of the reaction of resorcin and maleic anhydride in the presence of aluminum chloride in ethylene chloride solutions is cis-beta-2,4-dihydroxybenzoylacrylic acid (I). Cis and trans acids (I and II) were isomerized to 2-carboxy-7-hydroxychromanone-4(III). Reactions of acetylation of compounds I, II and III were studied.
mesh_terms: D000179:Acrylates / Q000138:chemical synthesis*; D000893:Anti-Inflammatory Agents / Q000138:chemical synthesis*; D055598:Chemical Phenomena; D002621:Chemistry; D002867:Chromones / Q000138:chemical synthesis*; D008968:Molecular Conformation
chemical_list: D000179:Acrylates; D000893:Anti-Inflammatory Agents; D002867:Chromones