title: The effect of sublethal concentrations of the molluscicide niclosamide on the infectivity of Schistosoma mansoni cercariae.
abstract: Experiments were conducted to assess the effect of sublethal concentrations of niclosamide on the infectivity of Schistosoma mansoni cercariae. Exposure of cercariae to 0.02 mg/l and 0.05 mg/l of niclosamide, respectively, for only two hours increased their mortality during penetration of mammalian host skin. The observed increase in mortality in the skin resulted in a consequent reduction of adult worm recovery from the liver and mesenteric veins of animals infected with the treated cercariae.
mesh_terms: D000818:Animals; D051379:Mice; D008975:Molluscacides / Q000494:pharmacology*; D009534:Niclosamide / Q000494:pharmacology*; D012550:Schistosoma mansoni / Q000187:drug effects* / Q000472:pathogenicity / Q000502:physiology; D012552:Schistosomiasis / Q000469:parasitology; D012867:Skin / Q000469:parasitology
chemical_list: D008975:Molluscacides; D009534:Niclosamide