Mycoplasma-mediated hyporeactivity to various interferon inducers.
Three strains of Mycoplasma arthritidis were shown to induce marked hyporeactivity in mice to interferon induction by both Newcastle disease virus and poly(I:C). In contrast, the interferon response of mice to tilorone was only partially suppressed by pretreatment of the animals with mycoplasms. Hyporeactivity to Newcastle disease virus was maximal 1 and 3 days after mycoplasms treatment, but the interferon response was maximal 1 day after injection of the mycoplasmas and was no longer apparent by 5 days. No relationship was found between the ability of the mycoplasms themselves to induce interferon and the degree of hyporeactivity produced. These results suggest that mycoplasmas may alter virus-host relationships in vivo.
D000818:Animals; D005260:Female; D007369:Interferon Inducers / Q000494:pharmacology*; D007372:Interferons / Q000032:analysis; D051379:Mice; D009174:Mycoplasma / Q000276:immunology; D009175:Mycoplasma Infections / Q000276:immunology*; D009521:Newcastle Disease / Q000209:etiology / Q000276:immunology; D009522:Newcastle disease virus; D011070:Poly I-C / Q000494:pharmacology
D007369:Interferon Inducers; D007372:Interferons; D011070:Poly I-C