Activation of the classical and alternate pathways of complement by Corynebacterium parvum.
The immunological adjuvant Corynebacterium parvum has been to activate the alternate pathway of complement in human and guinea-pig serum. Human serum in addition contains anti-C. parvum antibodies leading to activation of the classical complement pathway. The possible role of a C. parvum derived polysaccharide in this activation is considered in relation to the biological effects of the micro-organism.
D000372:Agglutination Tests; D000818:Animals; D000907:Antibodies, Bacterial / Q000032:analysis; D003172:Complement C1; D003175:Complement C2; D003176:Complement C3; D003181:Complement C4; D003165:Complement System Proteins; D006168:Guinea Pigs; D006801:Humans; D066298:In Vitro Techniques; D011135:Polysaccharides, Bacterial / Q000276:immunology; D011425:Propionibacterium acnes / Q000276:immunology*
D000907:Antibodies, Bacterial; D003172:Complement C1; D003175:Complement C2; D003176:Complement C3; D003181:Complement C4; D011135:Polysaccharides, Bacterial; D003165:Complement System Proteins