[Intrarenal distribution of calcium and magnesium in the dog. Effect of an osmotic diuresis (author's transl)].
1 The determination of Na, Ca, Mg, and K concentrations was performed in four different regions of the dog kidney (cortex, outer medulla, inner medulla, and papilla) during antidiuresis and during an osmotic diuresis. 2 The results show a medullary concentration gradient for calcium. This gradient is much higher than that found for sodium. 3 An inverse concentration gradient from cortex to inner medulla for Mg and K is found. 4 An osmotic diuresis (hypertonic mannitol) decreases the corticomedullary gradient of Na, but does not alter significantly the intrarenal distribution of Ca, Mg and K. 5 These results consistent with an intracellular localization of Mg and K in the renal tissue. It is suggested that the medullary concentration gradient for Ca may be due either to a countercurrent multiplier system similar to that for Na, or to a higher tissular fixation of Ca in the inner medulla and papilla than in the outer medulla and cortex.
D000818:Animals; D001692:Biological Transport; D002118:Calcium / Q000378:metabolism*; D004231:Diuresis / Q000187:drug effects; D004285:Dogs; D005260:Female; D007668:Kidney / Q000378:metabolism*; D007671:Kidney Concentrating Ability; D007672:Kidney Cortex / Q000378:metabolism; D007679:Kidney Medulla / Q000378:metabolism; D007684:Kidney Tubules / Q000502:physiology; D008274:Magnesium / Q000378:metabolism*; D008297:Male; D008353:Mannitol / Q000494:pharmacology; D009994:Osmolar Concentration; D011188:Potassium / Q000378:metabolism; D012964:Sodium / Q000378:metabolism
D008353:Mannitol; D012964:Sodium; D008274:Magnesium; D011188:Potassium; D002118:Calcium
Distribution intrarénale du calcium et du magnésium chez le chein Effet d'une diurèse osmotique