title: High permeability of insect blood-brain barrier to alcohols demonstrated by an electrophysiological technique.
abstract: Using the anaesthetic effects of the alcohols to measure their concentration within the cockroach central nervous system, it is shown that the lower homologues have access half-times of only a few seconds. Slower access of the higher homologues is interpreted in terms of a reservoir effect resulting from their higher liposolubility.
mesh_terms: D000200:Action Potentials / Q000187:drug effects; D000438:Alcohols / Q000494:pharmacology*; D000818:Animals; D001812:Blood-Brain Barrier; D000440:Butanols / Q000494:pharmacology; D003058:Cockroaches; D004305:Dose-Response Relationship, Drug; D000431:Ethanol / Q000494:pharmacology; D005727:Ganglia, Spinal / Q000187:drug effects* / Q000502:physiology; D000441:Hexanols / Q000494:pharmacology; D000442:Octanols / Q000494:pharmacology
chemical_list: D000438:Alcohols; D000440:Butanols; D000441:Hexanols; D000442:Octanols; D000431:Ethanol