Patterns of response to isoprenaline in asthmatic patients.
Six asthmatic patients whose airway obstruction improved significantly during a trial of prednisone have been studied in detail. Serial measurements of forced expiratory volume in 1 second (FEV1) were made at specific times each day before and after isoprenaline, for 8 days. Peak response was at 5 minutes in the majority of tests. In contrast to previous studies no clear pattern of response emerged in relation either to type of asthma, length of history or initial FEV1.
D000328:Adult; D000403:Airway Resistance / Q000187:drug effects; D000420:Albuterol / Q000627:therapeutic use; D001249:Asthma / Q000188:drug therapy*; D005260:Female; D005541:Forced Expiratory Volume; D006801:Humans; D007545:Isoproterenol / Q000494:pharmacology / Q000627:therapeutic use*; D008297:Male; D009921:Metaproterenol / Q000627:therapeutic use; D008875:Middle Aged; D010118:Oxytetracycline / Q000627:therapeutic use; D010366:Peak Expiratory Flow Rate; D011241:Prednisone / Q000627:therapeutic use; D013997:Time Factors
D009921:Metaproterenol; D007545:Isoproterenol; D000420:Albuterol; D011241:Prednisone; D010118:Oxytetracycline