[The effect of allopurinol on hemodynamic, respiratory and biochemical functional values in health persons following oral administration].
Starting from results of experimentation on animals, the influence of allopurinol on hemodynamic, respiratory and biochemical parameters after oral application by 10 probands in quiescence and after load had been studied. With mecanocardiographic, spiroergometric and circulation analytic function tests, no significative decrease of heart frequence, systolic blood pressure, pulse volume, heart minute volume, work of the heart, power of the heart and consumption of oxygen appears. The time of ejection diminished. Besides a pronounced sinking of the concentration of uric acid serum, it came to a suspension of the increase caused through load of the total free fatty acids and the beta-lipoproteide in the serum. The results indicate a circulation economized effect of allopurinol.
D000284:Administration, Oral; D000328:Adult; D000493:Allopurinol / Q000008:administration & dosage / Q000494:pharmacology*; D001775:Blood Circulation / Q000187:drug effects; D001794:Blood Pressure / Q000187:drug effects; D005230:Fatty Acids, Nonesterified / Q000097:blood; D006321:Heart / Q000187:drug effects; D006339:Heart Rate / Q000187:drug effects; D006439:Hemodynamics / Q000187:drug effects*; D006801:Humans; D008055:Lipids / Q000097:blood*; D005082:Physical Exertion; D011187:Posture; D012119:Respiration / Q000187:drug effects*; D014527:Uric Acid / Q000097:blood*; D014655:Vascular Resistance / Q000187:drug effects
D005230:Fatty Acids, Nonesterified; D008055:Lipids; D014527:Uric Acid; D000493:Allopurinol
Wirkung von Allopurinol auf hämodynamische, respiratorische und biochemische Funtionsgrössen bei Gesunden nach oraler Applikation