[Accumulation of basic amino acid residues, rate of autolysis and relative length of gut during trypsin evolution (author's transl)].
The study of six trypsins (crayfish, dogfish, horse, pig, sheep, bovine) showed that among these the highest lysine + arginine content and the highest inactivation rate occur in specialized herbivorous animals with extreme length of gut. Since the autocatalytic degradation in trypsins can take place only at lysine or arginine residues, an accumulation of basic amino acids, the increase of the autocatalytic inactivation rate and the relative length of gut might be correlated during the evolution of mammalian trypsins.
D000596:Amino Acids / Q000032:analysis; D000818:Animals; D001120:Arginine / Q000032:analysis; D001188:Artiodactyla / Q000033:anatomy & histology*; D003400:Astacoidea / Q000033:anatomy & histology*; D001329:Autolysis; D005075:Biological Evolution; D002417:Cattle / Q000033:anatomy & histology; D004284:Dogfish / Q000033:anatomy & histology*; D006736:Horses / Q000033:anatomy & histology*; D007422:Intestines / Q000033:anatomy & histology*; D008239:Lysine / Q000032:analysis; D012754:Sharks / Q000033:anatomy & histology*; D012756:Sheep / Q000033:anatomy & histology; D013552:Swine / Q000033:anatomy & histology; D014357:Trypsin / Q000032:analysis*
D000596:Amino Acids; D001120:Arginine; D014357:Trypsin; D008239:Lysine
Akkumulation basischer Aminosäurereste, Autolyse-Rate und relative Darmlänge in der Trypsin-Evolution