Effect of quinidine together with antibiotics on contractility of cat papillary muscle.
The extent of depression of myocardial contractility produced by the combination of quinidine and gentamicin, tetracycline, or amphotericin B was found, in an in vitro model, to be no greater than that due to the more active drug alone.
D000666:Amphotericin B / Q000494:pharmacology; D000818:Animals; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D002415:Cats; D003864:Depression, Chemical; D005839:Gentamicins / Q000494:pharmacology; D066298:In Vitro Techniques; D009200:Myocardial Contraction / Q000187:drug effects*; D010210:Papillary Muscles / Q000187:drug effects*; D011802:Quinidine / Q000494:pharmacology*; D013752:Tetracycline / Q000494:pharmacology
D000900:Anti-Bacterial Agents; D005839:Gentamicins; D000666:Amphotericin B; D013752:Tetracycline; D011802:Quinidine