Influence of catecholaminergic agents on narcotic binding in brain.
The effects of various agents on the specific tissue binding of 3H-naloxone and 3H-naltrexone were examined. In addition to the narcotics, alpha-adrenergic blockers and dopamine antagonists also significantly inhibited the specific bindings of these opiates. The binding of naloxone or naltrexone was not significantly altered by beta-adrenergic blockers, agents which block the effects of acetylcholine, serotonin and histamine at the receptor level, and a number of other drugs. Kinetic analyses revealed that the alpha-adrenergic and dopamine antagonists competitively inhibited the binding of naloxone. The results of these studies provide additional evidence for an interaction between the narcotics and catecholaminergic agents.
D000818:Animals; D001921:Brain / Q000187:drug effects / Q000378:metabolism*; D002395:Catecholamines / Q000502:physiology*; D004298:Dopamine / Q000494:pharmacology; D066298:In Vitro Techniques; D007700:Kinetics; D008297:Male; D009270:Naloxone / Q000031:analogs & derivatives* / Q000378:metabolism*; D009271:Naltrexone / Q000378:metabolism*; D009638:Norepinephrine / Q000494:pharmacology; D051381:Rats
D002395:Catecholamines; D009270:Naloxone; D009271:Naltrexone; D004298:Dopamine; D009638:Norepinephrine