[Osteomalacy induced by anticonvulsants. One case with a study of vitamin D metabolism].
A case of osteomalacia, with no cause apart from the ingestion of anti-convulsants, is reported. As was shown by a study with tritium labelled vitamin D, the metabolism of the latter was accelerated in this case in comparison with deficiency type osteomalacia. This lends support to the hypothesis that anti-convulsant medications, acting via a hepatic enzyme induction process, cause increased transformation of vitamin D into inactive metabolites, thus explaining a certain deficiency in vitamin D in treated epileptics, a deficiency state which requires treatment.
D000328:Adult; D000469:Alkaline Phosphatase / Q000097:blood; D000927:Anticonvulsants / Q000009:adverse effects* / Q000627:therapeutic use; D004827:Epilepsy / Q000188:drug therapy*; D005260:Female; D006801:Humans; D006887:Hydroxycholecalciferols / Q000097:blood; D010018:Osteomalacia / Q000139:chemically induced* / Q000378:metabolism; D010758:Phosphorus / Q000097:blood; D014807:Vitamin D / Q000378:metabolism*
D000927:Anticonvulsants; D006887:Hydroxycholecalciferols; D014807:Vitamin D; D010758:Phosphorus; D000469:Alkaline Phosphatase
L'ostéomalacie induite par les anticonvulsivants. Une observation avec étude du métabolisme de la vitamine D