Effect of progesterone on human corticosteroid 21-hydroxylation.
Progesterone inhibits the 21-hydroxylation of 17alpha-hydroxyprogesterone by human adrenal cortex microsomes. The possible light this finding may shed on the genetic condition, the 'adrenogenital syndrome' is discussed. Km and Vmax data for the above hydroxylation reaction are given.
D000302:Adrenal Cortex / Q000187:drug effects* / Q000378:metabolism; D000311:Adrenal Glands / Q000187:drug effects*; D003350:Cortodoxone / Q000378:metabolism; D006801:Humans; D006908:Hydroxyprogesterones / Q000378:metabolism*; D066298:In Vitro Techniques; D007700:Kinetics; D008861:Microsomes / Q000187:drug effects / Q000378:metabolism; D011374:Progesterone / Q000494:pharmacology*
D006908:Hydroxyprogesterones; D011374:Progesterone; D003350:Cortodoxone