[Morphologic studies on the effect of acrylnitrile in subchronic intoxication experiments in the white rat].
100 female and male white rats were treated with acrylnitrile using 4 various dosages. It was our practice to give orally acrylnitrile in physiological sodium chloride solution by probang, and the treatment was continued for 69 days from Monday to Friday in the week. After the treatment with acrylnitrile from the 70th day the animals were killed in intervals. Blood of orbital venous plexus was analysed by electrophoresis for determination of serum proteins, and organs were investigated histologically. It has been shown that of all organs the greatest alterations have been found in livers, kidneys and lungs. Taking by surprise our studies indicated that the application of 1/16 LD50 acrylnitrile dosage cause greater morphological damages in liver than those applications of higher concentrations in other groups.
D000179:Acrylates / Q000506:poisoning; D000818:Animals; D001798:Blood Proteins / Q000378:metabolism; D056486:Chemical and Drug Induced Liver Injury / Q000473:pathology; D005260:Female; D007668:Kidney / Q000187:drug effects / Q000473:pathology*; D008099:Liver / Q000473:pathology*; D008168:Lung / Q000187:drug effects / Q000473:pathology*; D008297:Male; D009570:Nitriles / Q000506:poisoning*; D051381:Rats
D000179:Acrylates; D001798:Blood Proteins; D009570:Nitriles
Morphologische Untersuchungen zur Wirkung von Acrylnitril im subchronischen Intoxikationsversuch bei der weissen Ratte