The synthesis and chemical properties of 3-chloromercury-2-hydroxipropyl-urea.
A simple and rapid method for the synthesis of 3-chloromercury-2-hydroxipropyl-urea has been described. It has been concluded that highest yields are obtained by the synthesis of 197HgO and allyl urea in the ratio of 2.5 : 1. Stability of the final preparation was investigated after thermal sterilization and standing at room temperature. It has been proved that the inorganic mercury-197 is not released. Radiochemical purity was controlled by chromatographic method using pyridine, n-butanol and water (3 : 10 : 3 v/v) as a solvent. The results obtained indicate that the preparation is applicable for human use.
D000085:Acetates; D002717:Chlormerodrin / Q000031:analogs & derivatives*; D004355:Drug Stability; D006358:Hot Temperature; D007553:Isotope Labeling; D007674:Kidney Diseases / Q000175:diagnosis; D008631:Mercury Radioisotopes; D009941:Organomercury Compounds / Q000138:chemical synthesis*; D011877:Radionuclide Imaging; D013997:Time Factors
D000085:Acetates; D008631:Mercury Radioisotopes; D009941:Organomercury Compounds; D002717:Chlormerodrin