The absence of an inhibitory effect of metyrapone (2-methyl-1,2-di (3-pyridyl) propan-1-one) on hepatic microsomal hydroxylation in scurvy.
Microsomes from livers of scorbutic guinea-pigs showed a reduced rate of acetanilide hydroxylation. The response of "scorbutic" liver microsomes to the inhibitor Metyrapone (2-methyl-1,2 di (3-pyridyl) propan-1-one) was different from that of liver microsomes from non-scorbutic guinea-pigs.
D000083:Acetanilides / Q000378:metabolism; D000311:Adrenal Glands / Q000378:metabolism; D000818:Animals; D001205:Ascorbic Acid / Q000378:metabolism; D006168:Guinea Pigs; D006900:Hydroxylation; D008297:Male; D008797:Metyrapone / Q000494:pharmacology*; D008862:Microsomes, Liver / Q000187:drug effects / Q000378:metabolism*; D012614:Scurvy / Q000378:metabolism*; D013154:Spleen / Q000378:metabolism
D000083:Acetanilides; D001205:Ascorbic Acid; D008797:Metyrapone