[Autoradiographic study of liver regeneration after treatment with carbon tetrachloride and heterologous antihepatic serum].
The authors carried out an autoradiographic study on the regeneratory processes in liver of 130 rats, which were treated with carbon tetrachloride and heterologous antiliver serum at various dilutions. The obtained results showed that this serum stimulated the synthesis of DNA in the parenchymal mesenchymal cells of liver, damaged diffusely. The effect of stimulation on DNA-synthesis in the animals of the experimental group, treated with 0,5 ml of heterolougous antiliver serum in dilution of 1:10 with saline, was mostly manifested. According to the authors the stimulation of DNA-synthesis was accomplished most probably by means of the mechanisms of the so called "immune enhancement".
D000818:Animals; D001345:Autoradiography; D002252:Carbon Tetrachloride Poisoning / Q000276:immunology*; D004247:DNA / Q000096:biosynthesis; D007106:Immune Sera / Q000494:pharmacology*; D007274:Injections, Intraperitoneal; D008099:Liver / Q000276:immunology*; D008115:Liver Regeneration / Q000187:drug effects*; D011817:Rabbits; D051381:Rats; D013936:Thymidine / Q000378:metabolism; D013997:Time Factors; D014316:Tritium
D007106:Immune Sera; D014316:Tritium; D004247:DNA; D013936:Thymidine
Avtoradiografsko prouchvane vurkhu chernodrobna regeneratsiia sled tretirane s vugleroden chetirikhlorid i kheterolozhen antichernodroben serum