[Enzyme levels and morphological picture of normal and cirrhotic rat livers following portal vein ligation and subcutaneous transposition of the spleen].
The effect of portal vein ligation after subcutaneous transposition of the spleen is investigated on enzyme-activities. and morphological pattern of the normal and cirrhotic rat-liver. The increase of glycolytic enzyme-activities and the decrease of enzyme-activities of oxidative metabolic pathways can be explained by adaptation on throttled blood supply of the liver. Significant decrease of arginase-activity (urea-cycle) can not be explained by reduced protein content of food (pair-fed-animals). Diminished substrate (ammonia)-level (NH3/t/hepatocytes) may be an explanation. Histological pattern of normal and cirrhotic rat liver is nearly unchanged after portal vein ligation.
D000818:Animals; D001119:Arginase / Q000032:analysis; D006019:Glycolysis; D008026:Ligation; D008099:Liver / Q000201:enzymology*; D008106:Liver Cirrhosis, Experimental / Q000201:enzymology* / Q000473:pathology; D011169:Portal Vein / Q000601:surgery*; D051381:Rats; D012092:Replantation / Q000379:methods; D013154:Spleen / Q000601:surgery*
D001119:Arginase
Enzymausstattung und morphologisches Bild der normalen und cirrhotischen Rattenleber nach Pfortaderligatur und Subcutantransposition der Milz