Aldactazide-induced consummatory and operant responding to sodium by rats.
The effects of intraperitoneal injections of Aldactazide-A on rats' consumption of water and saline solution (.51M NaCl) were tested in two experiments. During the treatment sessions, the rats showed a substantial increase in saline consumption and in lever pressing to a cue light to obtain the saline, as compared with their negligible intake before the injections and after the injections had been discontinued. The results indicate that both the drinkometer and operantbox measures are sensitive to the natroexigenic effects of Aldactazide.
D000818:Animals; D003216:Conditioning, Operant / Q000187:drug effects*; D004326:Drinking / Q000187:drug effects*; D004338:Drug Combinations; D005260:Female; D006852:Hydrochlorothiazide / Q000494:pharmacology*; D008297:Male; D051381:Rats; D012462:Saline Solution, Hypertonic; D012964:Sodium / Q000652:urine; D013148:Spironolactone / Q000494:pharmacology*; D014867:Water; D014868:Water Deprivation
D004338:Drug Combinations; D012462:Saline Solution, Hypertonic; D014867:Water; D006852:Hydrochlorothiazide; D013148:Spironolactone; D012964:Sodium