title: Effect of plasma protein binding on the anticoagulant action of warfarin in rats.
abstract: The relationships between the anticoagulant effect and the concentrations of free and total (sum of free and protein-bound) warfarin in plasma were determined in rats following intravenous administration of single doses of racemic warfarin or S(-)-warfarin. The concentration of total warfarin required to elicit a defined anticoagulant effect varied widely between animals while the concentration of free warfarin showed much less variation. This indicates that the anticoagulant effect of warfarin is a function of its free concentration in plasma.
mesh_terms: D000818:Animals; D001777:Blood Coagulation / Q000187:drug effects*; D001798:Blood Proteins / Q000378:metabolism*; D008297:Male; D011485:Protein Binding; D051381:Rats; D014859:Warfarin / Q000097:blood / Q000494:pharmacology*
chemical_list: D001798:Blood Proteins; D014859:Warfarin