Changes in serum tryptophan and albumin binding of tryptophan in chlorpromazine-treated chronic schizophrenics on withdrawal and restoration of drug therapy.
Withdrawal of drug from a group of chlorpromazine-treated chronic male schizophrenics led to a significant rise in the initially low serum tryptophan concentration, and a rise in the fraction freely diffusible. These changes, which would be expected to lead to an increase in tryptophan influx into the brain, and hence to an increase in cerebral serotonin synthesis, could be related to the clinical effects of drug withdrawal.
D000328:Adult; D000596:Amino Acids / Q000097:blood; D001921:Brain / Q000378:metabolism; D002746:Chlorpromazine / Q000627:therapeutic use*; D002908:Chronic Disease; D005230:Fatty Acids, Nonesterified / Q000097:blood; D006801:Humans; D008297:Male; D008875:Middle Aged; D010919:Placebos; D011485:Protein Binding; D012559:Schizophrenia / Q000188:drug therapy* / Q000378:metabolism; D012701:Serotonin / Q000378:metabolism; D012709:Serum Albumin / Q000378:metabolism*; D014364:Tryptophan / Q000097:blood* / Q000378:metabolism
D000596:Amino Acids; D005230:Fatty Acids, Nonesterified; D010919:Placebos; D012709:Serum Albumin; D012701:Serotonin; D014364:Tryptophan; D002746:Chlorpromazine