[Influence of nicotinic acid on the methylation of phospholipids in various tissues of rats].
The content and methylation of total phospholipids in the brain, liver and muscles and some of their fractions obtained by the method of thin-layer chromatography on silicic acid were studied as affected by nicotinic acid. It is established that nicotinic acid in a dose of 20 mg/kg 4 hrs after subcutaneous injection evokes an increase in the content of phosphatidyl ethanol amine in the liver and sphyngomyelin in the muscles. The intensity of methylation of choline-containing phospholipids under the effect of nicotinic acid lowers in all the tissues under study.
D000818:Animals; D001921:Brain / Q000378:metabolism*; D008099:Liver / Q000378:metabolism*; D008745:Methylation; D009132:Muscles / Q000378:metabolism*; D009539:Nicotinic Acids / Q000494:pharmacology*; D010713:Phosphatidylcholines / Q000378:metabolism; D010714:Phosphatidylethanolamines / Q000378:metabolism; D010718:Phosphatidylserines / Q000378:metabolism; D010743:Phospholipids / Q000378:metabolism*; D051381:Rats; D013109:Sphingomyelins / Q000378:metabolism
D009539:Nicotinic Acids; D010713:Phosphatidylcholines; D010714:Phosphatidylethanolamines; D010718:Phosphatidylserines; D010743:Phospholipids; D013109:Sphingomyelins
Vplyv nikotynovoï kysloty na metyliuvannia fosfolipidiv u riznykh tkanynakh shchuriv