Deficiency of the second component of complement (C2) with chronic vasculitis.
A patient had complete deficiency of the second component of complement associated with chronic vasculitis and increased susceptibility to infection. We discuss here results of the complement profile, histocompatibility typing, and studies of the functional properties of patient plasma or serum in chemotaxis and opsonization in relation to the disease entity and host susceptibility to infection.
D000328:Adult; D002908:Chronic Disease; D003175:Complement C2 / Q000172:deficiency*; D003165:Complement System Proteins / Q000172:deficiency*; D005260:Female; D006650:Histocompatibility Testing; D006801:Humans; D007153:Immunologic Deficiency Syndromes / Q000150:complications*; D007249:Inflammation / Q000150:complications / Q000276:immunology; D009895:Opsonin Proteins / Q000032:analysis; D014652:Vascular Diseases / Q000150:complications / Q000276:immunology*
D003175:Complement C2; D009895:Opsonin Proteins; D003165:Complement System Proteins