Nanomycins, new antibiotics produced by a strain of Streptomyces. II. Structure and biosynthesis.
Evidence is put forward which describes the structure and stereochemistry of new antibiotics, nanaomycins A and B, as I and V, respectively. In order to study biosynthesis and to determine the position of the hydroxyl group in the naphthoquinone moiety, a feeding experiment with 1-13C-acetate was effectively carried out. Nanaomycins A and B were found to be synthesized from acetate via a polyketide by Streptomyces rosa var. notoensis.
D000900:Anti-Bacterial Agents / Q000032:analysis / Q000096:biosynthesis; D055598:Chemical Phenomena; D002621:Chemistry; D009682:Magnetic Resonance Spectroscopy; D010636:Phenols / Q000032:analysis; D011809:Quinones / Q000032:analysis / Q000096:biosynthesis; D013302:Streptomyces / Q000378:metabolism*
D000900:Anti-Bacterial Agents; D010636:Phenols; D011809:Quinones