[Mode of action of bisacodyl (dulcolax) on isolated muscles of human colon (author's transl)].
The effects of bisacodyl (4,4-diacetyl-bis-hydroxyphenyl-pyridyl-(2)-methan, Dulcolax) on the tone of isolated muscle strips of human colon were examined. Maximal contractions achieved by 10 mug/ml of bisacodyl were quite comparable to those due to 1 mug/ml of acetylcholine, 1 mug/ml of histamine and 0.5 mug/ml of nicotine, respectively. However, peak contractions were attained with a greater latency and could not be prevented by the anticholinergic agent atropine, the H1-antihistaminic diphenhydramin or tetrodotoxin blocking axonal conduction. On the other hand, pretreatment with verapamil -- antagonizing calcium influx into the muscle cell -- abolished bisacodyl effects. These results provide evidence for a direct action of bisacodyl on smooth muscle cells of human colon.
D000109:Acetylcholine / Q000494:pharmacology; D001726:Bisacodyl / Q000494:pharmacology*; D003106:Colon / Q000187:drug effects*; D003408:Cresols / Q000494:pharmacology*; D004155:Diphenhydramine / Q000494:pharmacology; D004336:Drug Antagonism; D006632:Histamine / Q000494:pharmacology; D006801:Humans; D009119:Muscle Contraction / Q000187:drug effects; D009129:Muscle Tonus / Q000187:drug effects*; D009538:Nicotine / Q000494:pharmacology; D013779:Tetrodotoxin / Q000494:pharmacology; D014700:Verapamil / Q000494:pharmacology
D003408:Cresols; D001726:Bisacodyl; D013779:Tetrodotoxin; D009538:Nicotine; D006632:Histamine; D004155:Diphenhydramine; D014700:Verapamil; D000109:Acetylcholine
Wirkungsanalyse des Bisacodyl (Dulcolax) an der isolierten Dickdarmmuskulatur des Menschen