Collaboration of serotonin and melatonin in the control of thyroid function.
The stimulatory effect of serotonin and the inhibitory effect of melatonin on iodine incorporation by thyroid follicular cells are both inhibited by the serotonin antagonists methysergid and cyphroheptadine. Serotonin and melatonin can mutually prevent each other's action. A collaboration of melatonin and serotonin in the regulation of thyroid function is implied from the experimental observations.
D000818:Animals; D001667:Binding, Competitive; D003533:Cyproheptadine / Q000494:pharmacology; D004336:Drug Antagonism; D007455:Iodine / Q000378:metabolism; D008550:Melatonin / Q000494:pharmacology*; D008784:Methysergide / Q000494:pharmacology; D051381:Rats; D011955:Receptors, Drug; D012701:Serotonin / Q000494:pharmacology*; D013961:Thyroid Gland / Q000187:drug effects*
D011955:Receptors, Drug; D003533:Cyproheptadine; D012701:Serotonin; D007455:Iodine; D008550:Melatonin; D008784:Methysergide