title: [Immunogenesis and the functional state of the adrenals during tumor growth].
abstract: Based on the literature data and results of histochemical studies of fascicular and reticular zones of the adrenal gland, a conclusion is made that adrenal glucocorticoid function is impaired already during the initial period of malignification. During the stage of intensive tumor growth some signs of exhaustion of the fascicular zone are observed against the background of decreased protective functions of the connective tissue system; in the terminal period of the adrenal function and immunogenesis apparatus are found to be suppressed. The resistance to tumor growth is associated with activation of immuno-protective reactions of the organism and enhancement of the glucocorticoid function.
mesh_terms: D000302:Adrenal Cortex / Q000201:enzymology / Q000503:physiopathology*; D000311:Adrenal Glands / Q000503:physiopathology*; D000818:Animals; D008058:Dihydrolipoamide Dehydrogenase / Q000378:metabolism; D005260:Female; D005938:Glucocorticoids / Q000378:metabolism; D006854:Hydrocortisone / Q000627:therapeutic use; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D009368:Neoplasm Transplantation; D009374:Neoplasms, Experimental / Q000188:drug therapy / Q000276:immunology / Q000503:physiopathology*; D011817:Rabbits; D051381:Rats; D013045:Species Specificity
chemical_list: D005938:Glucocorticoids; D008058:Dihydrolipoamide Dehydrogenase; D006854:Hydrocortisone
vernacular_title: Funktsional'noe sostoianie nadpochechnikov i immunogenez pri opukholevom roste