A light and electron microscopic study of the changes in the duodenal mucosa induced by sustained pentagastrin stimulation of gastic acid secretion in young rats.
The histological and electron microscopic changes in the duodenal mucosa have been studied over an 8-week experimental period in rats whose gastric acid secretion was stimulated by pentagastrin in a medium of beeswax and mineral oil, and in controls that received injections of beeswax and mineral oil only. The changes leading of final disintegration of the epithelium are described in detail. The main aim of the experiment--to induce mucous change in the duodenal mucosa--was not realized.
D000818:Animals; D004386:Duodenum / Q000187:drug effects* / Q000473:pathology; D004847:Epithelial Cells; D004848:Epithelium / Q000378:metabolism / Q000648:ultrastructure; D005750:Gastric Juice / Q000378:metabolism*; D007413:Intestinal Mucosa / Q000187:drug effects* / Q000473:pathology; D008297:Male; D009336:Necrosis; D010418:Pentagastrin / Q000494:pharmacology*; D051381:Rats; D013270:Stomach / Q000187:drug effects; D013997:Time Factors
D010418:Pentagastrin