title: Effects of ADP and ATP on bovine fibrinogen- and ristocetin-induced platelet aggregation in Glanzmann's thrombasthenia.
abstract: With thrombasthenic platelets, aggregation induced by ristocetin (R) and bovine fibrinogen (BF) is reversible, provided ATP is not added to the system. ADP inhibits BF and R induced aggregation, and when added after the onset of aggregation causes rapid disaggregation. ATP prevents these inhibitory and disaggregation effects of ADP. A mechanism is suggested whereby co-operative effects occur between receptors in the membranes of thrombasthenic platelets.
mesh_terms: D000244:Adenosine Diphosphate / Q000494:pharmacology*; D000255:Adenosine Triphosphate / Q000494:pharmacology*; D000818:Animals; D001791:Blood Platelet Disorders / Q000097:blood*; D002417:Cattle; D005340:Fibrinogen / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D006801:Humans; D010974:Platelet Aggregation / Q000187:drug effects*; D012310:Ristocetin / Q000037:antagonists & inhibitors / Q000494:pharmacology*
chemical_list: D012310:Ristocetin; D000244:Adenosine Diphosphate; D000255:Adenosine Triphosphate; D005340:Fibrinogen