title: Aortic washout of 125I compounds in atherosclerotic and normal rabbits.
abstract: An in vivo rabbit model is described for the study of aortic washout of 125I tagged compounds. Washout is compartmental and in sequence from the lumen, aortic wall, and periaortic fat. Toluene-azo-naphthol (TAN) affixed chiefly to periaortic fat. A double isotope method with TAN plus a cholesterophilic substance is suggested for the assay of atherosclerosis in situ.
mesh_terms: D000818:Animals; D001011:Aorta / Q000378:metabolism*; D001161:Arteriosclerosis / Q000175:diagnosis* / Q000378:metabolism; D002784:Cholesterol / Q000302:isolation & purification*; D002791:Cholesterol, Dietary / Q000009:adverse effects; D004195:Disease Models, Animal; D005260:Female; D006801:Humans; D007457:Iodine Radioisotopes; D011817:Rabbits; D014050:Toluene / Q000031:analogs & derivatives
chemical_list: D002791:Cholesterol, Dietary; D007457:Iodine Radioisotopes; D014050:Toluene; D002784:Cholesterol