Sputum and serum levels of amoxycillin in chronic bronchial infections.
A study of 11 patients suffering from acute exacerbations of chronic bronchial infection, all with purulent (Mp+++) sputum, showed that good penetration of amoxycillin into such sputum occurs. The levels of amoxycillin in sputum doubled proportionally with the oral dose, at least up to dosages of 2 g. High dosages or oral amoxycillin may therefore, be advantageous in the treatment of chronic bronchial infection. In a study of 30 chronic bronchitic patients, whose sputum varied in purulence from mucoid to purulent (Mp+++) the concentration of amoxycillin in sputum containing approximately 50% pus (Mp++) was significantly higher than that in any other degree of purulence. These results indicate that amoxycillin penetrates best into sputum at an intermediate degree of purulence.
D000328:Adult; D000368:Aged; D000658:Amoxicillin / Q000008:administration & dosage / Q000032:analysis / Q000097:blood* / Q000378:metabolism; D000667:Ampicillin / Q000008:administration & dosage / Q000031:analogs & derivatives*; D001991:Bronchitis / Q000097:blood / Q000188:drug therapy*; D002908:Chronic Disease; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D013183:Sputum / Q000032:analysis* / Q000187:drug effects; D013492:Suppuration
D000667:Ampicillin; D000658:Amoxicillin