Effect of prostaglandins on protein, RNA, DNA and collagen synthesis in experimental wounds.
The effect of exogenous prostaglandins E1, E2 and F2alpha (PGE1, PGE2 and PGF2alpha) on 3H-leucine, 3H-uridine, 3H-thymidine and 3H-proline incorporation in experimental cutaneous wounds has been studied in rats. Prostaglandins E1 and E2 markedly stimulate the incorporation of these tritiated precursors, into protein, RNA, DNA and collagen synthesis, whereas F2 inhibits it. All tested prostaglandins exhibit their maximum effect within the first hours following administration. Most active is PGE1. These observations indicate that application of prostaglandins significantly stimulate incorporation with protein, RNA, DNA and collagen synthesis in the skin of wounded rats and thus, may play a role in epidermal cell growth and division as well as in scar-forming tissue.
D000818:Animals; D003094:Collagen / Q000096:biosynthesis*; D004247:DNA / Q000096:biosynthesis*; D007930:Leucine / Q000378:metabolism; D008297:Male; D011392:Proline / Q000378:metabolism; D011458:Prostaglandins E / Q000494:pharmacology*; D011460:Prostaglandins F / Q000494:pharmacology*; D014176:Protein Biosynthesis; D012313:RNA / Q000096:biosynthesis*; D051381:Rats; D013268:Stimulation, Chemical; D013936:Thymidine / Q000378:metabolism; D013997:Time Factors; D014529:Uridine / Q000378:metabolism; D014945:Wound Healing / Q000187:drug effects; D014947:Wounds and Injuries / Q000378:metabolism*
D011458:Prostaglandins E; D011460:Prostaglandins F; D012313:RNA; D003094:Collagen; D004247:DNA; D011392:Proline; D007930:Leucine; D013936:Thymidine; D014529:Uridine