title: Carbohydrate transport in Moniliformis dubius (Acanthocephala). I. The kinetics and specificity of hexose absorption.
abstract: The uptakes of 14C-glucose, -2-deoxyglucose, -mannose, -N-acetylglucosamine, -3-0-methylglucose, -fructose, and -galactose by female Moniliformis dubius were nonlinear, saturable functions of hexose concentration. Kinetic and inhibition studies indicated that glucose and 2-deoxyglucose were absorbed via a single common transport locus. Mannose, N-acetylglucosamine, 3-0-methylglucose, fructose, and galactose (in decreasing order of effectiveness) inhibited the uptake of glucose in a completely competitive manner; their absorptions appeared to be mediated by the glucose transport locus and, to some degree, by one or more additional transport systems. Kinetic studies suggested that the apparent inhibitions of 14C-glucose uptake by maltose and glucose-6-phosphate were due to free glucose liberated through the action of surface hydrolases. The uptake of 14C-glucose was also inhibited by salicin, alpha-methylglucoside, and beta-methylglucoside, but not by pentoses, L-hexoses, sugar alcohols, disaccharides (except maltose), gluconic acid, glucuronic acid, phlorizin, or ouabain. Glucose uptake was not Na+-dependent.
mesh_terms: D000049:Acanthocephala / Q000378:metabolism*; D000818:Animals; D001693:Biological Transport, Active; D050260:Carbohydrate Metabolism; D002463:Cell Membrane Permeability; D005260:Female; D005947:Glucose / Q000378:metabolism; D006601:Hexoses / Q000378:metabolism*; D007700:Kinetics; D008990:Moniliformis / Q000378:metabolism*; D012869:Skin Absorption; D012964:Sodium / Q000494:pharmacology
chemical_list: D006601:Hexoses; D012964:Sodium; D005947:Glucose