title: Synthesis of 6alpha-methyldigitoxigenin 3-acetate.
abstract: In order to determine the influence of a 6alpha-methyl group activity, the 6alpha-methyl derivative of digitoxigenin 3-acetate 14 was prepared and pharmacologically tested in comparison with digitoxigenen 3-acetate. The synthesis of 6alpha-methyldigitoxigenin 3-acetate (14) was performed starting from 21-hydroxy-4-pregnene-3,20-dione (1). According to the cardiac activity determined on guinea-pig isolated heart and by slow infusion in the cat, the 6alpha-methyldigitoxigenin 3-acetate (14) is not more active than digitoxigenin 3-acetate.
mesh_terms: D000818:Animals; D002297:Cardanolides / Q000138:chemical synthesis*; D002415:Cats; D004073:Digitoxigenin / Q000031:analogs & derivatives / Q000138:chemical synthesis* / Q000494:pharmacology; D006168:Guinea Pigs; D066298:In Vitro Techniques; D008968:Molecular Conformation; D009200:Myocardial Contraction / Q000187:drug effects; D013268:Stimulation, Chemical
chemical_list: D002297:Cardanolides; D004073:Digitoxigenin