Co-existent diabetes mellitus and diabetes insipidus, a familial disease.
Three male siblings with diabetes mellitus are described, two of whom also had coexistent diabetes insipidus. The co-existence of diabetes mellitus and insipidus appears to represent a single genetic abnormality and may or may not be accompanied by primary optic atrophy. Chlorpropamide was effective in controlling the symptoms of diabetes mellitus and diabetes insipidus.
D000328:Adult; D002747:Chlorpropamide / Q000627:therapeutic use; D003919:Diabetes Insipidus / Q000188:drug therapy / Q000235:genetics*; D003920:Diabetes Mellitus / Q000188:drug therapy / Q000235:genetics*; D003930:Diabetic Retinopathy / Q000235:genetics; D006801:Humans; D007671:Kidney Concentrating Ability; D008297:Male; D008875:Middle Aged; D012730:Sex Chromosomes; D014667:Vasopressins
D014667:Vasopressins; D002747:Chlorpropamide