Tumor-inhibitory agent from Montezuma speciosissima (Malvaceae).
The petroleum ether extract of Montezuma speciosissima Sesse and Moc. demonstrated tumor-inhibiting properties in the P-338 lympocytic leukemia test system (3PS). The constituent responsible for this activity was shown to be a symmetrically substituted 2,2'-dinaphthol, identified as gossypol (C30H30O8).
D000818:Animals; D000970:Antineoplastic Agents / Q000302:isolation & purification* / Q000627:therapeutic use; D006072:Gossypol / Q000302:isolation & purification* / Q000627:therapeutic use; D007942:Leukemia, Experimental / Q000188:drug therapy; D051379:Mice; D010944:Plants / Q000032:analysis*
D000970:Antineoplastic Agents; D006072:Gossypol