title: Reactivity of blood with biomaterials in vitro: evaluation of some in vitro test systems for estimation of the blood compatibility of biomaterials.
abstract: Several different in vitro tests designed to estimate the degree of compatibility of blood with biomaterials have been examined to determine possible effects of donor or donor-material interaction. Statistical evaluation of data was performed, and adequate data were collected with each different test system to render such evaluation meaningful. Isolated examples of donor and donor-material interaction were detected, but these proved to be minor or insignificant in each case. Data are presented for each of the in vitro test systems examined to indicate the number of replicate determinations required for observed differences to be significant at the 5% level.
mesh_terms: D001672:Biocompatible Materials; D001769:Blood; D001780:Blood Coagulation Tests; D002482:Cellulose; D003300:Copper; D005260:Female; D006801:Humans; D008297:Male; D011143:Polyvinyl Chloride; D000644:Quaternary Ammonium Compounds; D006435:Renal Dialysis; D012826:Silicone Elastomers; D013927:Thrombosis / Q000209:etiology
chemical_list: D001672:Biocompatible Materials; D000644:Quaternary Ammonium Compounds; D012826:Silicone Elastomers; D003300:Copper; D011143:Polyvinyl Chloride; D002482:Cellulose