Minocycline, doxycycline and tetracycline levels in serum and bronchial secretions of patients with chronic bronchitis.
Serum and sputum levels of minocycline, doxycycline and tetracycline were determined in patients with chronic bronchitis who were producing copious amounts of purulent sputum. Antibiotic estimations were carried out by the plate agar diffusion method using the Oxford staphylococcus. A close correlation was obtained between the sputum and the average serum levels for patients receiving tetracycline. Values obtained for minocycline showed a poor correlation between serum and sputum. A correlation between serum and sputum levels of doxycycline could not be established due to the low levels present in sputum. Our results indicate that while adequate serum levels of tetracycline reflect the attainment of theapeutic concentrations in bronchial secretions; the same predictions cannot be made for minocycline or doxycycline.
D001991:Bronchitis / Q000097:blood / Q000378:metabolism*; D002908:Chronic Disease; D004318:Doxycycline / Q000032:analysis* / Q000097:blood; D006801:Humans; D008911:Minocycline / Q000032:analysis* / Q000097:blood; D013183:Sputum / Q000032:analysis*; D013752:Tetracycline / Q000032:analysis* / Q000097:blood; D013754:Tetracyclines / Q000032:analysis*
D013754:Tetracyclines; D013752:Tetracycline; D008911:Minocycline; D004318:Doxycycline