[Cholestyramine for stress ulcer prophylaxis (author's transl)].
In rats the prophylactic effect of cholestyramine on the restraint stress ulcer formation was studied. After 9 hours of immobilisation animals, which were treated intragastrally with 0,3 g/kg cholestyramine, had only the fifth part of the ulcers of the controls, treated with Ringer solution. That demonstrated a very high effectivity of cholestyramine in the prevention of stress ulcers. The pathogenetic role of the bile for stress ulcer formation is as well discussed as the efficacy of cholestyramine. A clinical use for stress ulcer prophylaxis has to be considered.
D000818:Animals; D001647:Bile Acids and Salts; D002792:Cholestyramine Resin / Q000627:therapeutic use*; D004195:Disease Models, Animal; D007103:Immobilization; D008297:Male; D051381:Rats; D013276:Stomach Ulcer / Q000209:etiology / Q000517:prevention & control*; D013312:Stress, Physiological
D001647:Bile Acids and Salts; D002792:Cholestyramine Resin
Cholestyramin zur Stressulcus-Prophylaxe der Ratte