title: [Effect of D-penicillamine on the humoral primary response (author's transl)].
abstract: The influence of D-penicillamine (Pen) on the humoral primary response was studied systematically. Inbred rats are sensitized with erythrocytes of mice of one strain. Pen given at various schedules (dosage: 3 X 100 resp. 3 X 1000 mg/kg at 24 h intervals) showed no effect on antibody titer 7 days after sensitization. When Pen is given before the antigen the slope of the titer after day 7 is accelerated. Compared to experiments with alkylating drugs and antimetabolites in the same model Pen does not show immunosuppressive potency.
mesh_terms: D000818:Animals; D000917:Antibody Formation / Q000187:drug effects*; D000941:Antigens; D004912:Erythrocytes / Q000276:immunology; D007114:Immunization; D007074:Immunoglobulin G / Q000032:analysis; D007075:Immunoglobulin M / Q000032:analysis; D007165:Immunosuppression Therapy; D008297:Male; D051379:Mice / Q000276:immunology; D010396:Penicillamine / Q000494:pharmacology*; D051381:Rats
chemical_list: D000941:Antigens; D007074:Immunoglobulin G; D007075:Immunoglobulin M; D010396:Penicillamine
vernacular_title: Wirkung von D-Penicillamin auf die humorale Primärantwort