title: An assessment of the accuracy of computerized transverse axial scanning (EMI scanner) in the diagnosis of intracranial tumour. A review of 366 patients.
abstract: The computerized transverse axial (CTA) scans of 366 patients with intracranial tumours and 267 patients without tumours, but with similar presenting features, were analyzed. In all cases the definitive diagnosis was established either by histological or neurological methods. Most tumours were found to be of low tissue density, but a gradation from low through normal to a high density appearance was recognized. Tissue density enhancement with sodium iothalamate was achieved in 63-9% of supratentorial and 62-4% of infratentorial tumours, and usually allowed a more accurate determination to be made of the boundary between the tumour and the surrounding oedema. The accuracy of the CTA scanner as a screening technique was found to be 96%, this being superior to either clinical evaluation or rectilinear isotope scanning. When assessed on the basis of structural abnormalities demonstrated in the same groups of patients, the CTA scans enabled a diagnosis to be made or a lesion excluded in 92-3% of the patients, a figure which bears comparison with arteriography and pneumo-encephalography. It is anticipated that the simplicity and superior sensitivity of the system should decrease the necessity for invasive techniques such as angiography and pneumo-encephalography in the future.
mesh_terms: D000236:Adenoma / Q000175:diagnosis; D000293:Adolescent; D001254:Astrocytoma / Q000175:diagnosis; D002533:Cerebral Angiography; D003201:Computers; D003397:Craniopharyngioma / Q000175:diagnosis; D004806:Ependymoma / Q000175:diagnosis; D005188:False Negative Reactions; D005260:Female; D006801:Humans; D007089:Image Enhancement; D007483:Iothalamic Acid; D008297:Male; D008579:Meningioma / Q000175:diagnosis; D008875:Middle Aged; D009837:Oligodendroglioma / Q000175:diagnosis; D010911:Pituitary Neoplasms / Q000175:diagnosis; D011011:Pneumoencephalography; D011877:Radionuclide Imaging; D012888:Skull Neoplasms / Q000175:diagnosis; D014056:Tomography, X-Ray / Q000379:methods
chemical_list: D007483:Iothalamic Acid