[Dyserythropoietic anemia, type I: ineffective erythropoiesis due to disorders in the DNA-nucleoprotein complex].
The relative DNA, RNA histone and hemoglobin contents and 3H-thymidine incorporation in vitro were determined sequentially in individual erythroblasts of type I dyserythropoietic anemia. The histone/DNA ratio was increased due to a rise in histone extinction, indicating a pathological DNA-nucleoprotein complex. In addition, the erythroblasts displayed an increase in DNA content exceeding tetraploid values, a loss of DNA-synthesis activity at immature stages with low hemoglobin content, and a reduction of RNA. These variations were assumed to be caused by the preceding and primary impairment of the DNA-nucleoprotein complex.
D000328:Adult; D000741:Anemia, Aplastic / Q000097:blood*; D004247:DNA / Q000032:analysis; D004912:Erythrocytes / Q000378:metabolism*; D005260:Female; D006454:Hemoglobins; D006657:Histones / Q000032:analysis; D006801:Humans; D012313:RNA / Q000032:analysis
D006454:Hemoglobins; D006657:Histones; D012313:RNA; D004247:DNA
Dyserythropoietische Anämie vom Typ I: ineffektive Erythropoiese durch Störung im DNA-Nucleoprotein-Komplex