Spleen cells transmit osteopetrosis in mice.
Osteopetrosis was induced in lethally irradiated, normal mice of grey-lethal and microphthalmic stocks by cell infusions prepared from the spleens of osteopetrotic littermates. Failure of skeletal remodeling became evident within a few weeks after transplantation as calcified cartilage and bone accumulated excessively in the active metaphyses of the long bones. The massive lesions produced were extensively infiltrated with abnormal osteoclasts.
D000818:Animals; D001862:Bone Resorption; D005260:Female; D008297:Male; D051379:Mice; D010022:Osteopetrosis / Q000235:genetics / Q000503:physiopathology*; D013154:Spleen / Q000166:cytology / Q000503:physiopathology* / Q000637:transplantation; D013997:Time Factors; D014184:Transplantation, Homologous