title: [Gentamicin toxicity to animals of both sexes and different ages].
abstract: Gentamycin acute toxicity in sexually-immature and sexually-mature male and female rats was tested comparatively. DL50 for the female sexually-mature rats was found to be statistically reliable lower than that for the remaining three groups of animals. The greatest differences were observed in the values for the maximum non-lethal and minimum lethal doses of this antibiotic. The authors suggeste the use of a new index for the evaluation of gentamycin acute toxicity called Dose Range Index.
mesh_terms: D000367:Age Factors; D000818:Animals; D004305:Dose-Response Relationship, Drug; D004357:Drug Synergism; D005260:Female; D005839:Gentamicins / Q000008:administration & dosage / Q000494:pharmacology / Q000633:toxicity*; D007928:Lethal Dose 50; D008297:Male; D010634:Phenobarbital / Q000494:pharmacology; D051381:Rats; D012737:Sex Factors
chemical_list: D005839:Gentamicins; D010634:Phenobarbital
vernacular_title: Toksichnost na gentamitsin u razlichni po pol i vuzrast zhivotni