[Influence of sodium salicylate, acetylsalicylate, 2, 3-dihydroxybenzoic and 2, 3-diacetoxybenzoic acids on the blood coagulation system and the elimination of heparin].
Tests conducted on rabbits demonstrated that with a long-term enteral introduction (in amounts of 200 mg/kg, twice a day for 10 days) of 2-3-diacetoxybenzoic acid, sodium salicylate and acetylsalicylic acid these compounds depress the coagulation potential of the blood, 2-3-diacetoxybenzoic acid displaying also a hypocoagulation action even with its single administration in a dose of 400 mg/KJI. The said substances raise the level of the endogenous blood heparin and reinforce the anticoagulative action of heparin, 2-3-dioxybenzoic acid lowers somewhat the concentration and the anticlotting effect of heparin.
D000818:Animals; D001241:Aspirin / Q000008:administration & dosage / Q000494:pharmacology; D001777:Blood Coagulation / Q000187:drug effects*; D006493:Heparin / Q000378:metabolism*; D062385:Hydroxybenzoates / Q000008:administration & dosage / Q000494:pharmacology*; D011817:Rabbits; D012459:Salicylates / Q000008:administration & dosage / Q000494:pharmacology*
D062385:Hydroxybenzoates; D012459:Salicylates; D006493:Heparin; D001241:Aspirin
Vliianie natriia salitsilata, atsetilsalitsilovoĭ, 2-3-dioksibenzoĭnoĭ i 2-3-diatsetoksibenzoĭnoĭ kislot na sistemu svertyvaniia krovi i eliminatsiiu geparina