[Effect of increased diuresis on the renal excretion of sulfamerazine].
The excretion velocity of sulfamerazine is very slow, caused by a high reabsortion rate in renal tubuli. An increased diuresis by i.p. administration of saline or p.o. load with water has no effect on the sulfamerazine excretion velocity. The enhanced diuresis is accompanied by a decrease of the urine pH-value and consequently by a decreased dissociation rate of sulfamerazine.
D000818:Animals; D004231:Diuresis; D005260:Female; D007684:Kidney Tubules / Q000502:physiology; D051381:Rats; D012965:Sodium Chloride; D013416:Sulfamerazine / Q000652:urine*
D012965:Sodium Chloride; D013416:Sulfamerazine
Einfluss einer Diuresesteigerung auf die renale Ausscheidung von Sulfamerazin