[Effectiveness of vitamin A acid in diseases of the mouth mucosa: lichen ruber planus, leukoplakias and geographic tongue].
52 patients, with different pattern of oral lichen planus, pre-malignant leukoplakia or geographic tongue, were treated with vitamin A acid. The systemic medication resulted in regression of discrete papules and leukoplakia-like appearance of oral lichen planus. Linear-hypertrophic pattern of the oral mucosa showed distinct involution only by topical administration of vitamin A acid. Also the patients suffering from pre-malignant leukoplakia or geographic tongue partly improved after a vitamin A acid therapy. Systemic side effects were noted after ignoring the tolerance limit (30 mg/day vitamin A acid/3 weeks). Inflammation and occasionally maceration appeared when local treatment was used over 3 weeks. Recurrence was observed in 11 patients.
D000284:Administration, Oral; D000287:Administration, Topical; D005260:Female; D005929:Glossitis, Benign Migratory / Q000188:drug therapy; D006801:Humans; D007971:Leukoplakia / Q000188:drug therapy; D008010:Lichen Planus / Q000188:drug therapy; D008297:Male; D009059:Mouth Diseases / Q000188:drug therapy*; D014801:Vitamin A / Q000008:administration & dosage / Q000627:therapeutic use*
D014801:Vitamin A
Uber Wirksamkeit der Vitamin-A-Säure bei Erkrankungen der Mundschleimhaut: Lichen ruber planus, Leukoplakien und Lingua geographica