title: Cell-mediated immunity in idiopathic autoimmune haemolytic disease.
abstract: Membrane antigens from autologous and from allogeneic red blood cells (RBC) induced migration inhibition of splenic leucocytes and transformation of peripheral blood lymphocytes from a patient with idiopathic autoimmune haemolytic disease (AHD). No migration inhibition occurred following stimulation of splenic leucocytes obtained during splenectomy from a patient with beta-thalassaemia major. Lymphocyte transformation did not occur when normal lymphocytes were stimulated by similar RBC membrane preparations. These findings indicate that autosensitization in AHD may be a function of both humoral and cellular immune mechanisms.
mesh_terms: D000328:Adult; D000744:Anemia, Hemolytic, Autoimmune / Q000276:immunology*; D002464:Cell Migration Inhibition; D004912:Erythrocytes / Q000276:immunology; D005260:Female; D006801:Humans; D007111:Immunity, Cellular; D007962:Leukocytes / Q000276:immunology; D008213:Lymphocyte Activation; D013154:Spleen / Q000276:immunology