[Significance of intravascular coagulation and acidosis on increase of pulmonary vascular resistance following trauma and hemorrhagic shock].
24 anesthetized mongrel dogs are subjected to a standardized trauma followed by a hypotonic hemorrhagic shock. Compared with the control group (n equals 8) prophylactic treatment with heparin in the second group (n equals 8) reduces the rise of pulmonary vascular resistance only insignificantly. The correction of the metabolic acidosis with Tris does not prevent a rise of PVR in third group (n equals 8).
D000138:Acidosis / Q000503:physiopathology*; D000818:Animals; D001777:Blood Coagulation; D006493:Heparin / Q000494:pharmacology; D012771:Shock, Hemorrhagic / Q000503:physiopathology*; D012774:Shock, Traumatic / Q000503:physiopathology; D014655:Vascular Resistance / Q000187:drug effects; D014947:Wounds and Injuries / Q000503:physiopathology*
D006493:Heparin
Die Bedeutung der intravasalen Gerinnung und Acidose auf die Steigerung des pulmonalen Strömungswiderstandes nach Trauma und haemorrhagischem Schock