[The effect of leukocyte pyrogen on thermosensitive neurons of the anterior hypothalamus].
Impulse activity of neurons of the medial preoptic and septal brain areas of rabbits caused by variations in the local temperature and systemic injections of the leukocytic and bacterial pyrogens was studied. The firing rate of the warmsensitive neurons decreased and that of the cold thermodetectors was activated as a result of pyrogen action. As compared with the bacterial pyrogen, leukocytic pyrogen caused a more rapid decrease of the warmthermodetector activity. Thermoneutral neurons failed to react considerably either to the leukocytic or to the bacterial pyrogen.
D000818:Animals; D001419:Bacteria / Q000032:analysis; D007031:Hypothalamus / Q000187:drug effects*; D007962:Leukocytes / Q000032:analysis*; D011301:Preoptic Area / Q000187:drug effects*; D011749:Pyrogens / Q000494:pharmacology*; D011817:Rabbits; D012688:Septum Pellucidum / Q000187:drug effects*; D013823:Thermoreceptors / Q000187:drug effects*
D011749:Pyrogens
Vliianie leĭkotsitarnogo pirogena na termochuvstvitel'nye neĭrony perednego gipotalamusa