title: 6-Phosphogluconate dehydrogenase (PGD) genetics in the mouse: linkage with metabolically related enzyme loci.
abstract: An electrophoretic polymorphism of 6-phosphogluconate dehydrogenase (PGD) has been observed in the subspecies Mus musculus musculus from northern Denmark. M. m. musculus is interfertile with inbred strains of mice, and F1 hybrids with C57BL/6J show a three-banded phenotype. This pattern is consistent with a dimeric enzyme structure with codominant expression of alleles. In backcrosses and the F2 generation, PGD segregated as a singly autosomal gene, designated Pgd, closely linked to Gpd-1 on chromosome 4(1.7 +/- 1.1%). Both gene products are dimers, both require NADP, and these enzymes catalyze sequential steps in metabolism.
mesh_terms: D000483:Alleles; D000818:Animals; D002875:Chromosomes / Q000378:metabolism; D003433:Crosses, Genetic; D005260:Female; D008040:Genetic Linkage; D006824:Hybridization, Genetic; D007668:Kidney / Q000201:enzymology; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D010734:Phosphogluconate Dehydrogenase / Q000378:metabolism*; D011110:Polymorphism, Genetic; D011995:Recombination, Genetic
chemical_list: D010734:Phosphogluconate Dehydrogenase