[Age changes in rat vasomotor reflexes and sympathetic neuron ultrastructure following chemical sympathectomy].
Prolonged administration of guanethidine (20 mg/kg) to newborn rats caused a marked reduction in the number of cells in stellate ganglia. The administration of guanethidine for 14 days decreased the amount of cells to 30% of the normal (partial sympathectomy), and for 28 days--to 0.5% (complete sympathectomy). At the age of two months the blood pressure pressor reflexes to asphyxia and femoral nerve stimulation were absent in both groups of the sympathectomized animals. These responses, however, were restored in the partially sympathectomized animals at the age of four months. No restoration took place in the completely sympathectomized animals. The electron microscopic studies of neurons in the partially sympathectomized animals showed the presence of a great number of neurofibrils. According to literature data this fact was typical of cells in which an active growth of axon fibers took place.
D000375:Aging; D000818:Animals; D006145:Guanethidine; D009474:Neurons / Q000648:ultrastructure*; D051381:Rats; D012018:Reflex; D013564:Sympathetic Nervous System / Q000502:physiology* / Q000648:ultrastructure; D014666:Vasomotor System / Q000502:physiology*
D006145:Guanethidine
Vozrastnye izmeneniia vazomotornykh refleksov i ul'trastruktury simpaticheskikh neĭronov u krys posle khimicheskoĭ desimpatizatsii