[Changes in the glucocorticoid function of the adrenal cortex in patients with myocardial infarct treated with trioxazine and aminazine].
A protracted observation over the glucocorticoid function of the adrenal gland in patients with myocardial infarction educed a biphasic nature of changes in the concentration of the plasma and urine corticosteroids in this affection. Most informative are shown to be the evidences of activation of the hypothalamo-hypophysial-adrenal system furnished by the biologically active 11-oxycorticosteroids in the peripheral blood plasma. Psychopharmacological drugs produced a less intensive activation of the glucocorticoid function of the adrenal cortex in the acute period of myocardial infarction and they smooth down a renewed rise in the level of steroid during the subacute period of the disease. Chlorpromazine displays a stronger antistress action than does trioxazine, but the available data justify recommending both these drugs for the treatment of patients with myocardial infarction.
D015062:11-Hydroxycorticosteroids / Q000097:blood / Q000652:urine; D000222:Adaptation, Physiological; D000302:Adrenal Cortex / Q000503:physiopathology*; D000311:Adrenal Glands / Q000503:physiopathology*; D002746:Chlorpromazine / Q000627:therapeutic use*; D004359:Drug Therapy, Combination; D006801:Humans; D009025:Morpholines / Q000627:therapeutic use*; D009203:Myocardial Infarction / Q000188:drug therapy / Q000378:metabolism / Q000503:physiopathology*; D014149:Tranquilizing Agents / Q000627:therapeutic use*
D015062:11-Hydroxycorticosteroids; D009025:Morpholines; D014149:Tranquilizing Agents; D002746:Chlorpromazine
Izmeneniia gliukokortikoidnoĭ funktsii kory nadpochechnikov u bol'nykh infarktom miokarda, lechennykh trioksazinom i aminazinom