Pharmacologic properties of gama-aminobutyric acid (GABA) and its derivatives. V. Anticonvulsant action of alpha-,beta-, and gama-phenyl derivatives of GABA and their lactams.
The influence of alpha, beta, and gamma-phenyl derivatives of gamma-aminobutyric acid (GABA) and their lactams on convulsions induced with pentetrazole, bemegride and strychnine, and with electric current, were studied. All the lactams exhibited anticonvulsant action, prolonged the latent period of action of the convulsants, and in some cases diminished mortality due to intoxication. Acid forms were devoid of anticonvulsant properties, and in some cases even potentiated convulsions.
D000613:Aminobutyrates / Q000031:analogs & derivatives*; D000818:Animals; D000927:Anticonvulsants / Q000627:therapeutic use*; D001534:Bemegride / Q000494:pharmacology; D004357:Drug Synergism; D004558:Electric Stimulation; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D013331:Strychnine / Q000494:pharmacology; D047090:beta-Lactams / Q000627:therapeutic use*; D005680:gamma-Aminobutyric Acid / Q000031:analogs & derivatives*
D000613:Aminobutyrates; D000927:Anticonvulsants; D047090:beta-Lactams; D005680:gamma-Aminobutyric Acid; D001534:Bemegride; D013331:Strychnine