Deficiency of secretory Ig-A and intestinal malabsorption.
A patient under treatment with hemodialysis suffered increasing clinical and laboratory evidence of intestinal malabsorption. Jejunal aspirates revealed heavy bacterial and mycotic flora within the proximal jejunum. Secretory Ig-A and secretory component were present only in trace amounts. The deficiency of the generally ubiquitous secretory component is particularaly striking. Oral administration of 20-30 ml. colostrum daily reversed not only the clinical evidence but also laboratory findings of intestinal malabsorption.
D003126:Colostrum / Q000276:immunology; D004406:Dysgammaglobulinemia / Q000150:complications*; D006801:Humans; D007070:Immunoglobulin A; D007071:Immunoglobulin A, Secretory / Q000032:analysis; D007153:Immunologic Deficiency Syndromes / Q000150:complications*; D007419:Intestinal Secretions / Q000276:immunology; D007583:Jejunum / Q000382:microbiology; D008286:Malabsorption Syndromes / Q000276:immunology* / Q000382:microbiology / Q000628:therapy; D008297:Male; D008875:Middle Aged; D012463:Saliva / Q000276:immunology
D007070:Immunoglobulin A; D007071:Immunoglobulin A, Secretory