title: [Pharmaco-toxocologic study of the anti-tuberculosis preparation prothionimide].
abstract: Investigations of prothionamide effected on different animal species showed the drug to be of low toxicity. In relatively big doses it produced adynamia, hypothermy and a fall of arterial pressure. When employed in doses much higher (by 10-20 times) than therapeutic ones for humans prothionamide, when used repeatedly, may exercise a hepatotoxic action.
mesh_terms: D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D001831:Body Temperature / Q000187:drug effects; D002415:Cats; D005260:Female; D007539:Isonicotinic Acids / Q000633:toxicity*; D008099:Liver / Q000187:drug effects; D008297:Male; D051379:Mice; D011515:Prothionamide / Q000008:administration & dosage / Q000633:toxicity*; D051381:Rats
chemical_list: D007539:Isonicotinic Acids; D011515:Prothionamide
vernacular_title: Farmako-toksikologicheskoe izuchenie protivotuberkuleznogo preparata protionamida