Kininase and anti-inflammatory activities of acid carboxypeptidase from Penicillium janthinellum.
The acid carboxypeptidase from Penicillium janthinellum catalyzed the rapid release of arginine, and the slow release of phenylalanine, proline, serine and glycine from the carboxy-terminal of bradykinin at pH 4.15 to 4.8. Anti-inflammatory activity of the acid carboxypeptidase seems to suggest that the enzyme hydrolyzed bradykinin in vivo.
D000596:Amino Acids / Q000378:metabolism; D000818:Animals; D000893:Anti-Inflammatory Agents; D001920:Bradykinin / Q000378:metabolism*; D002268:Carboxypeptidases / Q000378:metabolism* / Q000494:pharmacology; D004487:Edema / Q000188:drug therapy; D006614:Hindlimb; D010407:Penicillium / Q000201:enzymology*; D051381:Rats
D000596:Amino Acids; D000893:Anti-Inflammatory Agents; D002268:Carboxypeptidases; D001920:Bradykinin