title: [Immunosuppressive long-term treatment of chronic aggressive hepatitis].
abstract: 47 patients with chronic aggressive hepatitis were immunosuppressively treated on the average 33.8 months (daily dose 100 mg azathioprine and 10 mg prednisolone). The serochemical parameters thymol, ZnSO4, GOT and GPT statistically significantly improved themselves. In 36 patients bioptic controls in 61.1% resulted in an improvement, and in 27.8% of the cases they resulted in a constancy of the histological findings. 10.6% of the patients died of a liver cirrhosis with portal hypertension. Nearly half the patients is capable to work. No severe side-effects appeared. The present results correspond to the results mentioned in literature. The chronic aggressive hepatitis, furthermore, should be added to a prednisone monotherapy or to a combination therapy of azathioprine and prednisone.
mesh_terms: D001379:Azathioprine / Q000008:administration & dosage / Q000627:therapeutic use*; D002908:Chronic Disease; D004357:Drug Synergism; D006505:Hepatitis / Q000188:drug therapy*; D006801:Humans; D011239:Prednisolone / Q000008:administration & dosage / Q000627:therapeutic use*; D013997:Time Factors
chemical_list: D011239:Prednisolone; D001379:Azathioprine
vernacular_title: Immunosuppressive Langzeitherapie der chronisch aggressiven Hepatitis