title: [Acceleration of passage through the small intestine by caerulein (author's transl)].
abstract: Passage through the small intestine was significantly accelerated after intramuscular injection of ceruletide (synthetic caerulein, F.I. 6934), 0.50 to 0.75 mug/kg body-weight. Average passage took 62 +/- 41 min (106 patients, with various suspected or demonstrated small-intestinal involvement, excluding malabsorption syndrome, sprue or collagen diseases) after caerulein, while in a control group of 83 patients with radiologically normal small intestine it was 126 +/- 62 min (P less than 0.001). In 75% of patients there was no evidence of induced change in radiological pattern of the small intestine. Increased local contractions were observed in a quarter of patients, but did not impair the diagnostic interpretation.
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D001692:Biological Transport / Q000187:drug effects; D002108:Ceruletide / Q000494:pharmacology*; D002648:Child; D005260:Female; D006801:Humans; D007273:Injections, Intramuscular; D007408:Intestinal Absorption / Q000187:drug effects; D007421:Intestine, Small / Q000000981:diagnostic imaging / Q000187:drug effects* / Q000378:metabolism; D008297:Male; D008722:Methods; D008875:Middle Aged; D011859:Radiography; D013997:Time Factors
chemical_list: D002108:Ceruletide
vernacular_title: Beschleunigung der Dünndarmpassage mit Caerulein