Differential effects of intraventricular administration of 6-hydroxydopamine on behavior of rats in approach and avoidance procedures: Reversal of avoidance decrements by diazepam.
The administration of 6-hydroxdopamine (6-HD) and pargyline to rats produced similar selective decreases in responding during the conditioned stimulus (CS) on a discriminated avoidance test where the unconditioned stimulus (US) was shock and on an analogous conditioned approach test where the US was water. Approach behavior during the CS generally recovered, however, while avoidance decrements in the same rats remained for the duration of testing. This suggested that 6-HD-induced avoidance decrement was a result of two independent but interacting processes: (1) a decrease in conditioned behavior as reflected by the similar decrease in responding on both tests; and (2) a hyper-reaction to aversive stimuli that resulted in a tendency to selectively suppress avoidance behavior after the animal received shock. In support of this hypothesis, it was found that 6-HD-induced avoidance decrements could be reversed (1) by treatment with diazpam, a drug that releases suppressed responses; or (2) by delaying avoidance testing until conditioned responding had recovered, thus minimizing the interaction of the two processes.
D000818:Animals; D001362:Avoidance Learning / Q000187:drug effects*; D001522:Behavior, Animal / Q000187:drug effects*; D001921:Brain / Q000378:metabolism; D002395:Catecholamines / Q000378:metabolism; D003213:Conditioning, Psychological / Q000187:drug effects; D003975:Diazepam / Q000494:pharmacology*; D004347:Drug Interactions; D004597:Electroshock; D006892:Hydroxydopamines / Q000008:administration & dosage / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D007276:Injections, Intraventricular; D008297:Male; D010293:Pargyline / Q000494:pharmacology; D051381:Rats; D011930:Reaction Time / Q000187:drug effects; D013997:Time Factors
D002395:Catecholamines; D006892:Hydroxydopamines; D010293:Pargyline; D003975:Diazepam