[A change in the concentration of DNA during radiation therapy of cancer of the larynx].
The author has studied microspectrophotometrically the DNA content in cell nuclei of 30 nonirradiated and 30 irradiated with different doses squamous-cell laryngeal cancers and their regional metastases in the growth zone of histological sections and in cytological specimens (impressions). The DNA "accumulation index" and polyploidization phenomenon were found to be considerably decreased depending on radiation dosage in the group of observations with a good clinical effect. In cytological preparations (impressions) these indices were lower, that seems to be related with the fact that cells of central tumor portions would get into the impression-preparation. Kinetic changes in the DNA content and a histographic type can characterize the tissue radiosensitivity, thus allowing an objective morphological control over radiation therapy.
D000328:Adult; D000368:Aged; D002294:Carcinoma, Squamous Cell / Q000378:metabolism / Q000532:radiotherapy*; D002467:Cell Nucleus / Q000378:metabolism; D004273:DNA, Neoplasm / Q000378:metabolism*; D005260:Female; D006651:Histocytochemistry; D006801:Humans; D007822:Laryngeal Neoplasms / Q000378:metabolism / Q000532:radiotherapy*; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D013053:Spectrophotometry
D004273:DNA, Neoplasm
Izmenenie soderzhaniia DNK v protsesse luchevogo lecheniia raka gortani