[Effect of alcohols on the rate of cholinesterase decarbamoylation].
Butanol-1 and butandiol-1,4 are shown to increase the decarbamoylation rate of N-methylcarbamoyl- and N,N-dimethylcarbamoyl-cholinesterase. It is mainly due to the formation of a ternary complex NEA which is decomposed in 2,5 times faster than corbamoyl-enzyme EA. This is an evidence for the presence of some allosteric center in cholinesterase which is capable of binding alcohols.
D000438:Alcohols / Q000494:pharmacology*; D000495:Allosteric Site; D000440:Butanols / Q000494:pharmacology; D002072:Butylene Glycols / Q000494:pharmacology; D002625:Chemistry, Organic; D002802:Cholinesterases / Q000378:metabolism*; D055601:Organic Chemistry Phenomena
D000438:Alcohols; D000440:Butanols; D002072:Butylene Glycols; D002802:Cholinesterases
Vliianie spirtov na skorost' dekarbamoilirovaniia kholinesterazy