Induction of midtrimester abortion with intraamniotic urea, intravenous oxytocin and laminaria.
Midtrimester abortion was accomplished in 75 patients by the intraamniotic instillation of 80 g of urea and the intravenous administration of oxytocin. In 33 of the patients, laminaria tents were inserted into the cervix. No severe complication occurred; all fetuses were stillborn. A single urea instillation was effective in 94.6% of the patients. The mean instillation-abortion interval was significantly (p less than 0.02) shorter in patients with laminaria tents than in those without. The tents probably prevent cervical rupture in s-me patients. Significant but transient changes occurred in platelet count and blood urea nitrogen one hour after urea instillation. Surgical removal of the placenta was required in 18.7% of the 75 patients; infection occurred in 2.6%. The combined use of urea, oxytocin, and laminaria appears to be an effective and relatively safe method of inducing abortion during the second trimester.
D000028:Abortion, Induced / Q000009:adverse effects; D000293:Adolescent; D000328:Adult; D000653:Amniotic Fluid; D005260:Female; D006801:Humans; D007263:Infusions, Parenteral; D007267:Injections; D010121:Oxytocin / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D011247:Pregnancy; D011262:Pregnancy Trimester, Second; D011453:Prostaglandins / Q000009:adverse effects / Q000627:therapeutic use; D012462:Saline Solution, Hypertonic; D012624:Seaweed; D013997:Time Factors; D014508:Urea / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*
D011453:Prostaglandins; D012462:Saline Solution, Hypertonic; D010121:Oxytocin; D014508:Urea