[Plasma concentrations of complement components C3, C4, and C3PA in juvenile nephropathies].
Complement profiles in children suffering for nephropathy have been investigated. The approach has proved useful in differentiating distinct nosologic entities. Plasma C3 and, to a lesser extent, C4 levels were found to be markedly reduced in glomerulonephritis and significantly increased in nephrotic syndrome. Although in both conditions plasma C3PA concentration ranges normally, additional data are request before assuming that alternate pathway is not involved. The extensive serial study of complement profiles should be widely adopted by clinicians managing nephropatic patients.
D000208:Acute Disease; D002648:Child; D002675:Child, Preschool; D002908:Chronic Disease; D003176:Complement C3 / Q000032:analysis; D003181:Complement C4 / Q000032:analysis; D003165:Complement System Proteins / Q000032:analysis*; D005260:Female; D005921:Glomerulonephritis / Q000276:immunology; D006801:Humans; D007674:Kidney Diseases / Q000276:immunology*; D008297:Male; D009404:Nephrotic Syndrome / Q000276:immunology
D003176:Complement C3; D003181:Complement C4; D003165:Complement System Proteins
Concentrazioni plasmatiche del componenti complementari C3, C4, e C3PA nelle nefropatie dell'eta' pediatrica