[Further investigations on cellular immunodeficiency in uraemic patients and the effect of haemodialysis (author's transl)].
The spontaneous rossette-formation of lymphocytes and the rate of the DNA-synthesis was determined in 33 uremic patients of the haemodialysis unit. 1. Spontaneous rosette-formation of uremic lymphocytes (39,5%,n=16) did not differ from normal lymphocytes (39,3%,n=39). 2. The absolute lymphocyte count was slightly but not significantly reduced in uremic patients compared to normal controls and the slight increase after dialysis was not significant. 3. The PHA-induced DNA-synthesis of lymphocytes of 23 uremic patients was significantly reduced compared to normal controls. 4. The reduced PHA-induced DNA-synthesis of lymphocytes of uremic patients was not different in patients dialysed two times (22 hours) per week and patients dialysed three times (30 hours) per week. 5. No correlation of the reduction of PHA-induced DNA-synthesis to the underlying renal-diseases could be found.
D000328:Adult; D004247:DNA / Q000096:biosynthesis; D005260:Female; D006801:Humans; D007104:Immune Adherence Reaction; D007111:Immunity, Cellular; D008213:Lymphocyte Activation; D008214:Lymphocytes / Q000276:immunology; D008297:Male; D008875:Middle Aged; D006435:Renal Dialysis; D014511:Uremia / Q000276:immunology*
D004247:DNA
Weitere Untersuchungen zum cellulären Immunmangel bei Patienten unter chronisch intermittierender Hämodialyse