The effect of ATP on lactic dehydrogenase (LDH) activity and influenza B virus multiplication.
The authors investigated the effect of ATP, an energy supplying substance, on the activity of LDH, an enzyme of the glycolytic pathway and on the multiplication of influenza virus strain B/Singapore in embryonate hen eggs. In the presence of ATP the increase in LDH activity could be detected from the first 1-3 hours and became obvious after 24 hours; likewise, virus multiplication was more intensive so that the hemagglutinating (HA) activity appeared 12 hours earlier than in controls and the increased HA values persisted for a longer time. The isoenzymatic pattern showed an intensification of LDH4 and LDH5 fractions in virus-inoculated eggs.
D000255:Adenosine Triphosphate / Q000494:pharmacology*; D000482:Allantois / Q000201:enzymology; D000818:Animals; D002642:Chick Embryo; D007527:Isoenzymes; D007770:L-Lactate Dehydrogenase / Q000032:analysis / Q000378:metabolism*; D009975:Orthomyxoviridae / Q000187:drug effects*; D014776:Virus Cultivation; D014779:Virus Replication / Q000187:drug effects*
D007527:Isoenzymes; D000255:Adenosine Triphosphate; D007770:L-Lactate Dehydrogenase