Studies on the calcemic effect of intravenous secretin in humans.
In healthy controls (n = 7), patients with duodenal ulcer (n = 7), primary hyperparathyroidism (n = 7), and 1 case of excluded gastric antrum the effects of intravenous secretin ("Karolinska"; 3 U/kg/h for 90 min) upon serum calcium fractions, total protein, and the integrated response of gastrin and glucagon were investigated. In all groups total calcium, total protein, and protein-bound calcium fraction rose significantly but the inonized calcium fraction remained stable. Since serum concentration of gastrin and glucagon could not be altered in any of the groups a direct interference of these hormones with calcium homeostasis during secretin infusion can be ruled out. Hyperparathyroid patients had higher baseline glucagon values (209 +/- 30 pg/ml) than normals (127 +/- 6 pg/ml) and ulcer patients (138 +/- 11 pg/ml) and maintained a higher hormone output throughout the experiment. Together with data on the patient with excluded antral parts it is concluded that the hypercalcemic effect of secretin is not mediated by calcium-regulating hormones but must be of an unspecific nature.
D000328:Adult; D001798:Blood Proteins / Q000032:analysis; D002116:Calcitonin / Q000502:physiology; D002118:Calcium / Q000097:blood; D005260:Female; D005755:Gastrins / Q000097:blood; D005934:Glucagon / Q000097:blood; D006801:Humans; D006934:Hypercalcemia / Q000139:chemically induced*; D006961:Hyperparathyroidism / Q000097:blood; D008297:Male; D008875:Middle Aged; D010710:Phosphates / Q000097:blood; D012633:Secretin / Q000009:adverse effects*
D001798:Blood Proteins; D005755:Gastrins; D010710:Phosphates; D012633:Secretin; D002116:Calcitonin; D005934:Glucagon; D002118:Calcium