[Amine receptors in brain vessels].
Isolated middle cerebral arteries from cats and pial arteries from humans (obtained during lobe resection) were studied in a sensitive in vitro system allowing a detailed pharmacological characterization of various amine receptors and related dissociation constants. It was found that the adrenergic receptors comprise contractile (alpha) and dilatory (beta) receptors. Acetylcholine induced dilation (at low doses) as well as constriction (at high doses) both responses being inhibited in a comparative way by atropine. Experiments with selective inhibitors showed the presence of specific histamine H2 (dilatory) receptors; at high doses histamine contracted the vessels in a non-specific way. 5-Hydroxytryptamine was the most efficient vasoconstrictor agent, and the response could be blocked by the serotonin-antagonist, methysergide.
D000109:Acetylcholine / Q000494:pharmacology; D000588:Amines / Q000378:metabolism*; D000818:Animals; D002415:Cats; D002536:Cerebral Arteries / Q000294:innervation*; D002628:Chemoreceptor Cells / Q000187:drug effects*; D003983:Dibenzylchlorethamine / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D004594:Electrophysiology; D004837:Epinephrine / Q000494:pharmacology; D006632:Histamine / Q000502:physiology; D006801:Humans; D066298:In Vitro Techniques; D007545:Isoproterenol / Q000494:pharmacology; D009119:Muscle Contraction / Q000187:drug effects; D009407:Nerve Block; D009638:Norepinephrine / Q000494:pharmacology; D010656:Phenylephrine / Q000494:pharmacology; D010841:Pia Mater / Q000098:blood supply; D011433:Propranolol / Q000494:pharmacology; D011941:Receptors, Adrenergic / Q000187:drug effects; D011950:Receptors, Cholinergic / Q000187:drug effects; D012701:Serotonin / Q000502:physiology
D000588:Amines; D011941:Receptors, Adrenergic; D011950:Receptors, Cholinergic; D010656:Phenylephrine; D012701:Serotonin; D003983:Dibenzylchlorethamine; D006632:Histamine; D011433:Propranolol; D007545:Isoproterenol; D000109:Acetylcholine; D009638:Norepinephrine; D004837:Epinephrine
Amino-retseptory v sosudakh mozga