[Research of an association between HL-A antigens and systemic scleroderma].
49 unrelated subjects suffering from systemic scleroderma were typed for 28 HL-A antigens, without any particular significant association of an antigen with the disease or one of its manifestations being noted. In addition, 13 patients from the same family were genotyped for HL-A. Transmission of the disease through 4 generations does not seem to be linked to a particular haplotype and no pair of sibling HL-A identical patients were seen in the same generation. By contrast, two pairs of sibling patients were HL-A different. Nevertheless, other cases, and in particular familial, will be necessary before an association between the genes of susceptibility to S.S. and a gene in the chromosomal HL-A region may be definitely eliminated.
D000328:Adult; D000368:Aged; D001327:Autoimmune Diseases / Q000175:diagnosis; D004935:Esophageal Diseases / Q000175:diagnosis; D005260:Female; D005838:Genotype; D006680:HLA Antigens / Q000032:analysis*; D006649:Histocompatibility Antigens / Q000032:analysis*; D006801:Humans; D007592:Joint Diseases / Q000175:diagnosis; D008297:Male; D008875:Middle Aged; D010375:Pedigree; D011928:Raynaud Disease / Q000175:diagnosis; D012140:Respiratory Tract Diseases / Q000175:diagnosis; D012595:Scleroderma, Systemic / Q000235:genetics / Q000276:immunology*; D012598:Sclerosis / Q000175:diagnosis
D006680:HLA Antigens; D006649:Histocompatibility Antigens
Recherche d'une association entre antigènes HL-A et sclérodermie systémique