title: The response of pancreatic and pituitary hormones to pulses and constant infusion of somatostatin.
abstract: The inhibitory action of pulses and constant infusion of somatostatin on the secretion of pancreatic and pituitary hormones was studied serially in 7 normal men and 2 untreated acromegalics. In normal men, significant inhibition of basal release of insulin and glucagon was elicited by as little as 1 mug dose of a pulse of somatostatin. Increasing doses of somatostatin (5, 50, 250 and 500 mug) given as a single pulse at weekly intervals produced what appears to be a decreased inhibition of glucagon while no measurable relationship between the dose of somatostatin and the degree of inhibition of insulin was seen. Given during the same day, incremental doses (from 1 to 250 mug) of pulses of somatostain produced a progressive decline in both glucagon and insulin. The elevated basal levels of GH, insulin and glucagon seen in acromegalics, were inhibited by a pulse of somatostatin as little as 2 mug. These inhibitions were sustained during the constant infusion of somatostatin (2.5 mug/min), and a rebound in GH, insulin and glucagon appeared promptly following the infusion.
mesh_terms: D000172:Acromegaly / Q000503:physiopathology; D004305:Dose-Response Relationship, Drug; D005934:Glucagon / Q000037:antagonists & inhibitors; D013006:Growth Hormone / Q000037:antagonists & inhibitors; D006801:Humans; D007329:Insulin Antagonists; D008297:Male; D010187:Pancreatic Hormones / Q000037:antagonists & inhibitors*; D010907:Pituitary Hormones / Q000037:antagonists & inhibitors*; D011388:Prolactin / Q000037:antagonists & inhibitors; D013004:Somatostatin / Q000008:administration & dosage / Q000494:pharmacology*; D013972:Thyrotropin / Q000037:antagonists & inhibitors
chemical_list: D007329:Insulin Antagonists; D010187:Pancreatic Hormones; D010907:Pituitary Hormones; D013004:Somatostatin; D011388:Prolactin; D013972:Thyrotropin; D013006:Growth Hormone; D005934:Glucagon