Effect of calcitonin on DNA synthesis in experimental wounds.
3H-thymidine incorporation and intracellular distribution in epidermal cells and fibroblasts of scar tissue from wounded rabbits were studied following synthetic salmon calcitonin administration. Both scintillation counting and electron microscopic autoradiography revealed a marked increase in 3H-thymidine incorporation within nuclear dense chromatin of epidermal and fibroblasts cells, mainly in 2-day wounded rabbits and at 2.5 hr. Then, 3H-thymidine uptake decreased moderately. These findings demonstrate an important role of calcitonin on DNA synthesis.
D000818:Animals; D001345:Autoradiography; D002116:Calcitonin / Q000494:pharmacology*; D004247:DNA / Q000096:biosynthesis*; D008854:Microscopy, Electron; D011817:Rabbits; D012867:Skin / Q000293:injuries*; D013268:Stimulation, Chemical; D014945:Wound Healing
D002116:Calcitonin; D004247:DNA