[Formation of a generator of excitation in the gigantocellular nucleus of the medulla oblongata during disruption of inhibitory processes].
Neuronal activity in the gigantocellular nucleus after injection of tetanus toxin was studied on decerebrated cats. The toxin was used as a substance producing a deep and continuous suppression of inhibitory processes. The increase in the amplitude and rate of neuronal discharges, in the integral background and evoked activity as well as in the number of active neurons and that of neurons with burst activity was recorded in the "poisoned" nucleus. The enhanced activity in the investigated regions of the poisoned nucleus might be temporarily suppressed by a strong direct electrical shock and by glycin administrations to those regions. The obtained data indicate that a pool of neurons with disturbed inhibitory processes forms a generator of enhanced excitation. The mechanisms and characteristic features of the activity of such generators are discussed. The possibility of modelling neurological syndromes by production of similar generators in various parts of the central nervous system and their relation to the earlier described phenomenon of "dispatch station" are considered.
D000818:Animals; D002415:Cats; D003655:Decerebrate State; D004336:Drug Antagonism; D005071:Evoked Potentials / Q000187:drug effects; D005998:Glycine / Q000494:pharmacology; D008526:Medulla Oblongata / Q000187:drug effects*; D013744:Tetanus Toxin / Q000494:pharmacology*
D013744:Tetanus Toxin; D005998:Glycine
Obrazovanie generatora vozbuzhdeniia v gigantokletochnom iadre prodolgovatogo mozga pri narushenii tormoznykh protsessov