[Resorption, deposition and assimilation in rabbits and piglets of new Bulgarian iron-dextran complexes as compared to Myofer-100 and Ferroglukin-75].
Followed up was the resorption (in rabbits) and the deposition and utilization (in pigs) of two new Bulgarian ferrodextran complexes (A-100 and B-75) compared with Myofer-100 and Ferroglukin-75. According to their resorption as determined by the sideremia and the coloration of tissues at the side of injection, the ferrodextran preparations are divided into fast-resorbing and slow-resorbing. The preparations A-100 and Myofer-100 are resorbed 8--10 times faster than the preparations B-75 and feroglukin-75. Greatest portions of iron are distributed per gram of tissue in the regional lymph nodes, followed by the liver and spleen. Upon applying the preparations at sites of the hind part of the body the lymph nodes of the front part of the body assume more intensely the colour of the fastresorbing preparations. This may be used as a test indicating the character of resorption. No direct correlation was established between the rate of resorption and the stimulation of the growth in pigs. It has been found that the optimal dose of the preparations A-100 and Myofer-100 for pigs is 160 mg Fe3+, while of the preparations B-75 and Ferroglukin-75 it is higher. It was found that in terms of resorption, coloration of tissues, distribution in the organisms, and utilization per cent the preparation A-100 is more advantageous than B-75, is equal to Myofer-100, is resorbed better, and colours to a slighter extent the tissues than Ferroglukin-75.
D000818:Animals; D002031:Bulgaria; D006128:Growth; D007501:Iron / Q000097:blood; D007505:Iron-Dextran Complex / Q000378:metabolism*; D008099:Liver / Q000378:metabolism; D008198:Lymph Nodes / Q000378:metabolism; D011817:Rabbits; D012869:Skin Absorption / Q000187:drug effects; D013154:Spleen / Q000378:metabolism; D013552:Swine
D007505:Iron-Dextran Complex; D007501:Iron
Rezorbtsiia, otlagane i usvoiavane pri zaĭtsi i praseta na novi bulgarski zheliazo-dekstranovi kompleksi, sravneni s miofer-100 i ferogliukin-75