[Effect of tuberculosis infection and antibacterial preparations on thiamine metabolism].
Effects of tuberculous infection and monotherapy during three months with ethyone amide, etoxide and canamycin on thiamin metabolism were studied. The state of the metabolism was estimated by monitoring the content of radioactive thiamin in tissues and blood and by following its excretion. In guinea pigs generalized tuberculosis caused impairments in utilization of the administered thiamin. Content of the vitamin was decreased 3.5-4 fold in tissues, especially, in kidney and liver tissue but its excretion from the organism was increased almost three-fold as compared with healthy animals. Treatment of animals with ethyone amide, etoxide and canamycin within three months did not restore the impaired thiamin metabolism. In the animals the assimilation of the administered thiamin constituted 17,5-20% as compared with healthy animals; this phenomenon was accompanied by an increased urinary excretion of the vitamin.
D000818:Animals; D005000:Ethionamide / Q000494:pharmacology* / Q000627:therapeutic use; D005019:Ethyl Ethers / Q000494:pharmacology* / Q000627:therapeutic use; D006168:Guinea Pigs; D007612:Kanamycin / Q000494:pharmacology* / Q000627:therapeutic use; D007668:Kidney / Q000187:drug effects / Q000378:metabolism; D008099:Liver / Q000187:drug effects / Q000378:metabolism; D009928:Organ Specificity; D013831:Thiamine / Q000378:metabolism*; D014376:Tuberculosis / Q000188:drug therapy / Q000378:metabolism*
D005019:Ethyl Ethers; D007612:Kanamycin; D005000:Ethionamide; D013831:Thiamine
Vliianie tuberkuleznoĭ infektsii i antibakterial'nykh preparatov na obmen tiamina v eksperimente