title: The analysis of binary responses from toxicological experiments involving reproduction and teratogenicity.
abstract: This paper describes a parametric method for analyzing binary response data from completely randomized experiments in which the experimental units are animal litters. Responses within a litter are assumed to form a set of Bernoulli trials whose success probability varies between litters in the same treatment group according to a two parameter beta distribution. The parameters of the beta distribution for each treatment are estimated by maximum likelihood and treatment differences are tested by asymptotic likelihood ratio tests.
mesh_terms: D000818:Animals; D005260:Female; D011247:Pregnancy; D013223:Statistics as Topic; D013723:Teratogens; D014116:Toxicology
chemical_list: D013723:Teratogens