title: The quantitative relations between diffusion-controlled reaction rate and characteristic parameters in enzyme-substrate reactions systems. II. Charged substrates.
abstract: The quantitative relationship between the spatial factor and the force-range factor on the one hand and the ionic strength and the charges of reactants on the other has been calculated for non-spherically symmetric reaction systems. New upper limits of combination reactions between enzymes and charged substrates have been obtained. Applying the calculated results to the reactions catalyzed by fumarase and D-glyceraldehyde-3 phosphate dehydrogenase, we have been able to interpret experimental phenomena which could not be accounted for by the conventional theory of the diffusion-controlled reaction. Furthermore, the conditions under which the Bronsted equation is valid in the non-equilibrium steady state reaction system have been discussed.
mesh_terms: D001665:Binding Sites; D004058:Diffusion; D004798:Enzymes / Q000378:metabolism*; D005650:Fumarates / Q000378:metabolism; D005987:Glyceraldehyde-3-Phosphate Dehydrogenases / Q000378:metabolism; D007700:Kinetics; D008956:Models, Chemical; D009994:Osmolar Concentration
chemical_list: D004798:Enzymes; D005650:Fumarates; D005987:Glyceraldehyde-3-Phosphate Dehydrogenases