title: [Some pathomorphological bases for the disorders of the tissue amino acid pool in Salmonella infection].
abstract: Possible causes of disturbances of the amino acid pool of the blood serum and the tissue, as well as the presence of an association between these shifts and the changes in the ultrastructure of the striated columnar epithelium of the small intestine were studied. Investigations were conducted in 138 patients suffereing from salmonellosis and in 120 albino rats experimentally-infected with S. typhimurium culture. Free amino acids of the blood serum and the tissue were determined by paper chromatography and on the automatic amino acid analyzer; ultrastructure of the small intestinal mucosa was studied by electron microscopy. The height of salmonella infection was attended by dysproportional changes in the amino acid pool of the tissue and the blood caused by disturbance of absorption and intracellular transformation of amino acids. Ultrastructural changes in the microvilli of the absorbing cells of the small intestine underlied absorption disturbances: at the height of salmonella infection some of the microvilli of the striated columnar small intestine proved to show poor contours; reduction of mitochondrial cristae was observed in almost all the mitochondria.
mesh_terms: D000293:Adolescent; D000328:Adult; D000596:Amino Acids / Q000032:analysis / Q000378:metabolism*; D000818:Animals; D001322:Autoanalysis; D002854:Chromatography, Paper; D003289:Convalescence; D004847:Epithelial Cells; D004848:Epithelium / Q000648:ultrastructure; D005609:Free Radicals; D006801:Humans; D007413:Intestinal Mucosa / Q000648:ultrastructure; D007421:Intestine, Small / Q000648:ultrastructure; D008297:Male; D008875:Middle Aged; D051381:Rats; D012480:Salmonella Infections / Q000378:metabolism* / Q000473:pathology; D012481:Salmonella Infections, Animal / Q000378:metabolism / Q000473:pathology
chemical_list: D000596:Amino Acids; D005609:Free Radicals
vernacular_title: O nekotorykh patomorfologicheskikh osnovakh narusheniia tkanevogo aminokislotnogo pula pri sal'monelleznoĭ infektsii