[Effect of ingestion of derivatives of quinoxaline on the enzymatic detoxication activity of hepatic microsomes in the rat].
Female rats received quinoxaline, 2,3-dimethyl quinoxaline, 2,3-diphenyl quinoxaline and 2,3-dithiol quinoxaline by oral intubation for 4 days (500 mg/kg/day) and drug-metabolizing enzymes were investigated. A significant stimulation in liver microsomal enzymes occurred after 2,3-dimethyl quinoxaline and 2,3-diphenyl quinoxaline treatments; these changes were associated with increases in cytochrome P-450 level and in RNA and protein contents of the microsomal fraction. Quinoxaline had no effect on the metabolic rate of the studied substrates but increased the cytochrome P-450 and the RNA and protein levels; whereas, 2,3-dithiol quinoxaline inhibited the aminopyrine and N-methylaniline N-demethylations and decreased the cytochrome P-450 per mg microsomal protein.
D000818:Animals; D001711:Biotransformation; D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism; D005260:Female; D066298:In Vitro Techniques; D008658:Inactivation, Metabolic; D008862:Microsomes, Liver / Q000187:drug effects / Q000201:enzymology*; D006899:Mixed Function Oxygenases / Q000378:metabolism; D009696:Nucleic Acids / Q000378:metabolism; D011506:Proteins / Q000378:metabolism; D011810:Quinoxalines / Q000494:pharmacology*; D012313:RNA / Q000378:metabolism; D051381:Rats
D009696:Nucleic Acids; D011506:Proteins; D011810:Quinoxalines; D012313:RNA; D003577:Cytochrome P-450 Enzyme System; D006899:Mixed Function Oxygenases
Effet de l'lngestion de dérivés de la quinoxaline sur les activités de détoxication enzymatique des microsomes hépatiques du rat