[Effect of nicotinic acid and prozerin on choline metabolism].
The content and specific activity of labelled methyl groups of choline and phosphorylcholine in the brain, liver and skeletal muscles of rats was studied as affected by nicotinic acid and prozerin, injected subcutaneously 4h before decapitation. It was found that under the effect of prozerin the specific activity of choline lowers only in the muscles and nicotinic acid evokes its decrease in the liver and muscles. The specific activity of phosphorylcholine lowers in the brain and liver with introduction of prozerin and nicotinic acid. The intensity of phosphorylcholine phosphate renewal increases in the liver and skeletal muscles after introduction of both prozerin and nicotinic acid. The activity of choline dehydrogenase in the liver homogenates lowers only with injection of nicotinic acid.
D000818:Animals; D001921:Brain / Q000187:drug effects / Q000378:metabolism; D002794:Choline / Q000378:metabolism*; D008099:Liver / Q000187:drug effects / Q000378:metabolism; D009132:Muscles / Q000187:drug effects / Q000378:metabolism; D009388:Neostigmine / Q000494:pharmacology*; D009539:Nicotinic Acids / Q000494:pharmacology*; D009928:Organ Specificity; D010767:Phosphorylcholine / Q000378:metabolism; D051381:Rats
D009539:Nicotinic Acids; D010767:Phosphorylcholine; D009388:Neostigmine; D002794:Choline