Stability of frozen rat plasma containing different antibiotics.
The antibiotic activity was determined at different intervals of time on plasma samples, taken from rats treated with a certain number of commonly used antibiotics, and kept at -20 C up to 8 weeks. The results of the microbiological assays demonstrate that the stability of the antibiotics in the frozen plasma decreases in the following order: oxytetracycline > cephalexin, streptomycin, erythromycin > demeclocycline > ampicillin, amoxycillin > penicillin G, cephaloridine, rolitetracycline, and tetracycline.
D000818:Animals; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D002511:Cephalosporins / Q000494:pharmacology; D004355:Drug Stability; D004917:Erythromycin / Q000494:pharmacology; D066298:In Vitro Techniques; D008297:Male; D051379:Mice; D010406:Penicillins / Q000494:pharmacology; D010949:Plasma / Q000187:drug effects* / Q000382:microbiology; D013307:Streptomycin / Q000494:pharmacology; D013754:Tetracyclines / Q000494:pharmacology; D013997:Time Factors
D000900:Anti-Bacterial Agents; D002511:Cephalosporins; D010406:Penicillins; D013754:Tetracyclines; D004917:Erythromycin; D013307:Streptomycin