Porphobilinogen and porphyrin synthesis in reticulocytes from uraemic patients.
Since no information exists concerning porphyrin metabolism in uraemic patients we have measured the activities of delta-aminolaevulinic acid dehydrase (D-ALA-D) and porphobilinogen desaminase (PBG-D) in reticulocytes from uraemic patients, anaemic patients without uraemia and in healthy subjects. Despite a severe anaemia uraemic patients had the same amount of reticulocytes/mul blood. In uraemic patients D-ALA-D activity was reduced to about 20% compared to healthy subjects, PBG-D in uraemia was decreased to about 70%. It is concluded that porphyrin metabolism is altered in uraemic patients.
D058186:Acute Kidney Injury / Q000097:blood / Q000201:enzymology; D000642:Ammonia-Lyases / Q000378:metabolism*; D000740:Anemia / Q000097:blood / Q000201:enzymology; D002908:Chronic Disease; D006801:Humans; D006836:Hydro-Lyases / Q000378:metabolism*; D011163:Hydroxymethylbilane Synthase / Q000378:metabolism*; D000623:Porphobilinogen Synthase / Q000378:metabolism*; D012156:Reticulocytes / Q000201:enzymology*; D014511:Uremia / Q000097:blood / Q000201:enzymology*
D011163:Hydroxymethylbilane Synthase; D006836:Hydro-Lyases; D000623:Porphobilinogen Synthase; D000642:Ammonia-Lyases