[Importance of urinary 3-O methyldopamine in the metabolism of adrenergic tumors].
Urinary 3-O methyldopamine has been found highly increased in all cases of malignant tumours, as well of sympathetic nature (sympathoblastoma) as of chromaffin type (pheochromocytoma) but at a lesser extent in benign sympathetic tumours (ganglioneuroma). On the other hand, 3-O methyldopamine excretion is normal in benign pheochromocytoma. The ratio of this compound in the dopaminergic block is increased in sympathoblastoma, decreased in ganglioneurona and unchanged in pheochromocytoma. This kind of analysis has not been made for the case of malignant pheochromoblastoma. This ratio of 3-O methyldopamine in the whole dopaminergic and noradrenergic metabolism is increased only in sympathoblastoma. In the other cases (ganglioneuroma and pheochromocytoma) this ratio is decreased. Comparative analysis of urinary 3-O methyldopamine and the two other methoxylated amines (norepinephrine and metanephrine) shows that the methoxylated derivative of dopamine, when compared to normal subjects values, increased at the greatest extent in sympathoblastoma, while in ganglioneurona and chromaffin tumours, normetanephrine is with a variable degree, the predominant compound.
D000328:Adult; D002648:Child; D002675:Child, Preschool; D003846:Deoxyepinephrine / Q000652:urine*; D004298:Dopamine / Q000031:analogs & derivatives*; D005729:Ganglioneuroma / Q000378:metabolism*; D006801:Humans; D007223:Infant; D009447:Neuroblastoma / Q000378:metabolism*; D010524:Peripheral Nervous System Neoplasms / Q000378:metabolism*; D010673:Pheochromocytoma / Q000378:metabolism*
D003846:Deoxyepinephrine; D004298:Dopamine
Importance de la 3-O méthyldopamine urinaire dans le métabolisme des tumeurs adrénergiques