title: A general program to estimate gene-frequencies by the method of maximum-likelihood.
abstract: The program estimates the optimal gene-frequencies from observed values of phenotypes by the method of maximum-likelihood. The program does not make assumptions about a specific blood-group-system. This information has to be supplied by input cards. A straightforward iteration process is used for obtaining initial estimates for the gene-frequencies in question. Then an iterative application of the Newton-Raphson method is used to solve the maximum-likelihood equations. The program yields the gene-frequencies and their standard deviations, expected values of the phenotypes, expected values of the genotypes. Finally the chi-square between observed frequencies and (optimal) expected values of phenotypes is computed.
mesh_terms: D003201:Computers; D005787:Gene Frequency; D005838:Genotype; D008954:Models, Biological; D010641:Phenotype