[Production and testing of biologically active fibers with hemostatic properties].
The authors presented the method of laboratory elaboration of biologically active surgical sutures with hemostatic and antiiinflammatory properties as developed by the Leningrad S. M. Kirov Memorial Institute of Textile and Light Industry. With the carboxyl groups of the KFM type fibres (addition product of polyvinylfurfural with maleic acid) adrenalin sorbed from aqueous suspensions was linked by ionic bond. The sutures were tested in the A. I. Bakuliev Memorial Institute of Cardiovascular Surgery. Due to the slow release of adrenalin the sutures exert hemostatic effect. In the in vitro tests there were determined the serum calcium level, hemolysis of red blood cells, pH, prothrombin time and plasma protein content changes. The authors showed also preliminary data on the sterilization of the fibres.
D001808:Blood Vessels / Q000187:drug effects; D004837:Epinephrine / Q000378:metabolism / Q000494:pharmacology; D005662:Furaldehyde / Q000031:analogs & derivatives / Q000378:metabolism; D006487:Hemostasis / Q000187:drug effects; D006488:Hemostasis, Surgical; D008293:Malates / Q000378:metabolism; D011145:Polyvinyls / Q000378:metabolism; D013537:Sutures / Q000592:standards
D008293:Malates; D011145:Polyvinyls; C012003:polyvinylfurfural; D005662:Furaldehyde; D004837:Epinephrine
Poluchenie i issledovanie biologicheski aktivnykh volokon, obladaiushchikh gemostaticheskim effektom