[Changes induced with cyclophosphamide in the lympho-reticular elements with specific enzymatic activities of the splenic white pulp in rats and guinea-pigs].
The effect of cyclophosphamide, one potent immunosupressor drug, was used to differenciate the behaviour of two types of Reticular cells, the phosphatasic acid and the 5'nucleotidasic cells. The first exhibit macrophagic and migratory properties, the second are devoid of these criteria but remain associated with the presence of T-lymphocytes. This suggests its possible role in the nutrition and the differential evolution of T-lymphocytes.
D000135:Acid Phosphatase / Q000378:metabolism*; D000818:Animals; D003520:Cyclophosphamide / Q000494:pharmacology*; D006168:Guinea Pigs; D008214:Lymphocytes / Q000187:drug effects; D009708:Nucleotidases / Q000378:metabolism*; D051381:Rats; D013154:Spleen / Q000187:drug effects* / Q000201:enzymology
D003520:Cyclophosphamide; D009708:Nucleotidases; D000135:Acid Phosphatase
Altérations provoquées par l'action du cyclophosphamide sur les elements lympho-réticulaires à activités enzymatiques spécifiques de la pulpe blanche splénique du rat et du cobaye