Reversal of experimental allergic thyroiditis in cyclophosphamide-treated rats.
A 10-day course of cyclophosphamide completely reversed the histopathological manifestations of experimental allergic thyroiditis in Wistar rats. This therapeutic effect of cyclophosphamide was sustained, no recrudescence of thyroid inflammation being detected among rats examined 4 weeks after immunosuppressive therapy.
D000818:Animals; D000906:Antibodies / Q000032:analysis; D001327:Autoimmune Diseases / Q000188:drug therapy*; D003520:Cyclophosphamide / Q000627:therapeutic use*; D005260:Female; D006386:Hemagglutination Tests; D051381:Rats; D013954:Thyroglobulin / Q000032:analysis; D013961:Thyroid Gland / Q000276:immunology; D013966:Thyroiditis / Q000188:drug therapy* / Q000276:immunology
D000906:Antibodies; D003520:Cyclophosphamide; D013954:Thyroglobulin