[Serum level of thyroxin-binding globulin under oral contraception (author's transl)].
The use of oral contraceptives results in an increase in thyroid-binding-capacity in conformity with a change of results by T3/T4-tests. Using Laurell-electrophoresis and an anti-serum produced by Behringwerke the determination of the thyroid-binding-globulin (TBG) in serum is easy to handle. TBG was determined in serum from 137 women using oral contraceptives for more than 3 months. The apllication of oral contraceptives is followed by a statistically significant increase in the TBG level in serum. Thereby oral contraceptives change the TBG-level in a different degree. Preparations with a marked estrogen potency on the average effect a higher TBG-concentration than those with progesterone activity derived by menses-delay test. The difference of TBG-level is statistically significant. According by the increase of TBG-concentration in serum is caused by estrogen, the extent of the increase is modified by the progesterone component.
D000293:Adolescent; D000328:Adult; D001769:Blood; D003276:Contraceptives, Oral / Q000008:administration & dosage*; D003278:Contraceptives, Oral, Hormonal / Q000008:administration & dosage*; D003279:Contraceptives, Oral, Sequential / Q000008:administration & dosage; D003280:Contraceptives, Oral, Synthetic / Q000008:administration & dosage; D006801:Humans; D013974:Thyroxine / Q000097:blood; D014284:Triiodothyronine / Q000097:blood
D003276:Contraceptives, Oral; D003278:Contraceptives, Oral, Hormonal; D003279:Contraceptives, Oral, Sequential; D003280:Contraceptives, Oral, Synthetic; D014284:Triiodothyronine; D013974:Thyroxine
Das Verhalten des thyroxinbindenden Globulins (TBG) unter oraler hormonaler Kontrazeption