Anticestode quinolinehydrazones.
One hundred and seven 4-quinolinehydrazones were synthesized and tested in vivo against the tapeworm Hymenolepis nana. Twenty-five derivatives showed significant cestocidal activity; structure-activity correlations were performed using Free-Wilson methodology. Two compounds, 2,6-dimethyl-4-[(3-pyridinylmethylene)hydrazino]quinoline and 2,6-dimethyl-4-[2p][(6-methyl)pyridinylmethylene]hydrazino)quinoline, predicted to be maximally active, effected 100% reduction of H. nana in mice at 200 mg/kg, p.o.
D000818:Animals; D000923:Anticestodal Agents / Q000627:therapeutic use; D006835:Hydrazones / Q000494:pharmacology / Q000627:therapeutic use*; D006925:Hymenolepiasis / Q000188:drug therapy*; D006926:Hymenolepis / Q000187:drug effects; D008297:Male; D051379:Mice; D011804:Quinolines / Q000494:pharmacology / Q000627:therapeutic use*; D013329:Structure-Activity Relationship
D000923:Anticestodal Agents; D006835:Hydrazones; D011804:Quinolines