title: Ultrastructural response of epidermis to actinomycin D.
abstract: The response of the epidermis to the effects of actinomycin D was analyzed at ultrastructural level. Important cellular alterations were found at 40 h post infectionem. The degree of nucleolar segregation varied depending on the epidermal layer assayed. Analogies and departures between the present findings and previous investigations, on a similar model with X-ray irradiation, are discussed.
mesh_terms: D000818:Animals; D002466:Cell Nucleolus / Q000648:ultrastructure; D002467:Cell Nucleus / Q000648:ultrastructure; D003594:Cytoplasmic Granules / Q000648:ultrastructure; D003609:Dactinomycin / Q000494:pharmacology*; D051381:Rats; D012867:Skin / Q000187:drug effects* / Q000648:ultrastructure
chemical_list: D003609:Dactinomycin