title: Structural studies of metabolic products of dopamine. IV. Crystal and molecular structure of (-)-noradrenaline.
abstract: The crystal structure of (-)-noradrenaline has been determined by X-ray methods, using 1000 observed reflections collected by counter diffractometer techniques. The crystals are orthorhombic, space group P212121, with a=8.611(2), B=6.138(2), And c=14.912(4) A. Least-squares refinements yielded a conventional R-factor of 0.036. Standard deviations in bond lengths are 0.003 A and in bond angles 0.2 degrees. The crystal structure of (-)-noradrenaline corresponds closely to that of (-)-adrenaline in molecular geometry, conformation, and arrangement in the crystals. The results of the structure investigations are discussed in relation to the biological activity of these biogenic amines.
mesh_terms: D055598:Chemical Phenomena; D002621:Chemistry; D003461:Crystallography; D004298:Dopamine; D008958:Models, Molecular; D008968:Molecular Conformation; D009638:Norepinephrine; D011941:Receptors, Adrenergic; D013329:Structure-Activity Relationship; D014961:X-Ray Diffraction
chemical_list: D011941:Receptors, Adrenergic; D004298:Dopamine; D009638:Norepinephrine