title: [Study of the pharmacokinetics of phosphemide in rats with the use of physico-chemical methods].
abstract: A study on the passage of phosphemide with urine and distribution of the drug over the organs and tissues of intact (without fumour) rats and those with sarcoma-45 showed the bulk of unchanged drug to be excreted together with the urine during the first 3-4 hours following its intravenous and intraperitoneal administration. In rats with sarcoma-45 phosphamide is passed with urine in a somewhat greater amount than in the intact animals. With intravenous application the rate of the drug elimination in intact rats and in the ones with carcoma-45 is virtually the same, being somewhat lower with intraperitoneal injection of phosphemide.
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000008:administration & dosage / Q000378:metabolism*; D001388:Aziridines / Q000008:administration & dosage / Q000378:metabolism*; D001389:Azirines / Q000378:metabolism*; D009943:Organophosphorus Compounds / Q000008:administration & dosage / Q000378:metabolism*; D051381:Rats; D012513:Sarcoma, Experimental / Q000378:metabolism; D013997:Time Factors
chemical_list: D000970:Antineoplastic Agents; D001388:Aziridines; D001389:Azirines; D009943:Organophosphorus Compounds
vernacular_title: Izuchenie farmakokinetiki fosfemida u krys s pomoshch'iu fiziko-khimicheskikh metodov