Damage and recovery assessment of the mouse jejunum to abdominal X-ray and adriamycin treatment.
The influence of adriamycin on the post-irradiation proliferative response of the mouse jejunum was examined. Doses of either 5 or 10 mg/kg of adriamycin administered immediately after abdominal irradiation reduced the LD50/7 days by 300-400 R. Neither dosage of the drug reduced the number of surviving crypts, as measured by the crypt isolation and microcolony techniques, for a given radiation exposure. However, both drug dosages reduced the amount of post-irradiation compensatory hyperplasia, as measured by 3H-thymidine incorporation.
D000818:Animals; D002455:Cell Division / Q000187:drug effects / Q000528:radiation effects; D004317:Doxorubicin / Q000009:adverse effects / Q000494:pharmacology*; D005260:Female; D007583:Jejunum / Q000187:drug effects / Q000528:radiation effects*; D007928:Lethal Dose 50; D051379:Mice; D011829:Radiation Dosage; D011830:Radiation Effects
D004317:Doxorubicin