title: The effect of ATP on lactic dehydrogenase (LDH) activity and influenza B virus multiplication.
abstract: The authors investigated the effect of ATP, an energy supplying substance, on the activity of LDH, an enzyme of the glycolytic pathway and on the multiplication of influenza virus strain B/Singapore in embryonate hen eggs. In the presence of ATP the increase in LDH activity could be detected from the first 1-3 hours and became obvious after 24 hours; likewise, virus multiplication was more intensive so that the hemagglutinating (HA) activity appeared 12 hours earlier than in controls and the increased HA values persisted for a longer time. The isoenzymatic pattern showed an intensification of LDH4 and LDH5 fractions in virus-inoculated eggs.
mesh_terms: D000255:Adenosine Triphosphate / Q000494:pharmacology*; D000482:Allantois / Q000201:enzymology; D000818:Animals; D002642:Chick Embryo; D007527:Isoenzymes; D007770:L-Lactate Dehydrogenase / Q000032:analysis / Q000378:metabolism*; D009975:Orthomyxoviridae / Q000187:drug effects*; D014776:Virus Cultivation; D014779:Virus Replication / Q000187:drug effects*
chemical_list: D007527:Isoenzymes; D000255:Adenosine Triphosphate; D007770:L-Lactate Dehydrogenase