[Use of gutimin for the treatment of experimental traumatic shock].
The guthymine medication of a severe shock in rats started 10-20 minutes after injury is shown to eliminate energy metabolism disorders in the brain, liver and kidneys. In the brain of the guthamyine treated rats even a somewhat reduced adenosinetriphosphate content was demonstrable. Administration of guthymine together with polyglucin to cats in a torpid phase of the shock did not effect treir survival, but shortened the life-span of the test animals as compared to controls (receiving polyglucin alone). With guthymine addid to polyglucin the lactate and pyruvate concentration in the blood remained unchanged.
D000578:Amidines / Q000627:therapeutic use*; D000818:Animals; D001921:Brain / Q000187:drug effects; D002415:Cats; D004353:Drug Evaluation, Preclinical; D007668:Kidney / Q000187:drug effects; D008099:Liver / Q000187:drug effects; D008297:Male; D051381:Rats; D012774:Shock, Traumatic / Q000188:drug therapy*; D013890:Thiourea / Q000031:analogs & derivatives* / Q000627:therapeutic use*
D000578:Amidines; D013890:Thiourea
K voprosu o primenenii gutimina dlia lecheniia éksperimental'nogo travmaticheskogo shoka