title: Selective chemical changes of gonadotropic hormones by means of neuraminidase from Vibrio cholerae.
abstract: Experiments indicate that Neuraminidase from Vibrio Cholerae selectively cleaves sialic acid derivate from FSH, but leaves the LH sialic acid derivative. By performing a specific test for LH - the OAAD test - we found that the LH activity is not influenced by the presence of Neuraminidase. The FSH activity is destroyed by Neuraminidase but the enzyme itself influences the ovarian weight, resulting in a weight decrease observed 48 hours after injection. Before or after this "critical time" no decrease is observed.
mesh_terms: D000818:Animals; D005260:Female; D006801:Humans; D006868:Hydrolysis; D007986:Luteinizing Hormone / Q000032:analysis*; D008297:Male; D051379:Mice; D009439:Neuraminidase / Q000494:pharmacology; D009929:Organ Size; D010053:Ovary / Q000032:analysis / Q000187:drug effects; D051381:Rats; D012794:Sialic Acids / Q000032:analysis; D014599:Uterus / Q000032:analysis / Q000187:drug effects; D014734:Vibrio cholerae / Q000201:enzymology
chemical_list: D012794:Sialic Acids; D007986:Luteinizing Hormone; D009439:Neuraminidase