[Difference in the cerebrovascular effects of phenoxybenzamine].
The isotope, electromagnetic and resistographic investigation showed phenoxybenzamine to be capable of producing different effects on the blood supply of different regions of the brain. The preparation enhanced the circulation of the vertebro-basilar system and decreased it in the carotic one. Phenoxybenzamine also significantly inhibited the nervous control of the cerebral circulation. It inhibited the reflex reaction of cerebral vessels, changed the cerebral blood flow by stimulation of cervical sympathetic nerves and was capable of protecting against experimental cerebrovascular disorders. These data allow one to recommend phenoxybenzamine in neurological and neurosurgical clinics for the treatment of cerebrovascular disorders in the vertebro-basilar arterial system.
D000818:Animals; D002415:Cats; D002560:Cerebrovascular Circulation / Q000187:drug effects*; D010643:Phenoxybenzamine / Q000494:pharmacology*; D012018:Reflex / Q000187:drug effects; D014666:Vasomotor System / Q000187:drug effects
D010643:Phenoxybenzamine
Razlichie v tserebrovaskuliarnykh éffektakh fenoksibenzamina