Separation of ABH, I, Ss antigenic activity from the MN-active sialoglycoprotein of the human erythrocyte membrane.
The erythrocyte sialoglycoprotein was purified from cells with complementary ABO(H), MN and Ss phenotypes. Serological examination of the sialoglycoprotein preparations demonstrated that this molecule does not carry the ABO(H), I or Ss antigens. The results also suggest that Ss activity may be associated with a minor erythorcyte glycoprotein. The characteristics of the ABO(H) and I antigens are consistent with earlier suggestions that these antigens are carried on complex glycolipids.
D000017:ABO Blood-Group System; D001789:Blood Group Antigens; D002462:Cell Membrane / Q000276:immunology; D004912:Erythrocytes / Q000276:immunology; D006023:Glycoproteins / Q000097:blood / Q000302:isolation & purification*; D006801:Humans; D007048:I Blood-Group System; D007519:Isoantigens / Q000032:analysis / Q000302:isolation & purification*; D008951:MNSs Blood-Group System; D010455:Peptides / Q000032:analysis; D012794:Sialic Acids / Q000097:blood / Q000302:isolation & purification*
D000017:ABO Blood-Group System; D001789:Blood Group Antigens; D006023:Glycoproteins; D007048:I Blood-Group System; D007519:Isoantigens; D008951:MNSs Blood-Group System; D010455:Peptides; D012794:Sialic Acids