Regulation of circulating parathyroid hormone levels: normal physiology and consequences in disorders of mineral metabolism.
A review of the chemistry, the biosynthesis, the regulation of the secretion and the metabolism of parathyroid hormone (PTH) provides a background to problems related to the determination of immunoreactive PTH levels in the blood of normal subjects and of patients suffering from disorders of mineral metabolism. Immunoreactive PTH measurements have to be interpreted in the light of the immunoheterogeneity encountered and the occurrence of several circulating PTH species with different molecular weights and immunological properties.
D002116:Calcitonin / Q000097:blood; D002118:Calcium / Q000097:blood; D002128:Calcium Metabolism Disorders / Q000097:blood / Q000503:physiopathology*; D005260:Female; D006801:Humans; D006961:Hyperparathyroidism / Q000097:blood; D006962:Hyperparathyroidism, Secondary / Q000097:blood; D007011:Hypoparathyroidism / Q000097:blood; D007231:Infant, Newborn; D007676:Kidney Failure, Chronic / Q000097:blood; D007680:Kidney Neoplasms / Q000097:blood; D008113:Liver Neoplasms / Q000097:blood; D008274:Magnesium / Q000378:metabolism; D008970:Molecular Weight; D010024:Osteoporosis / Q000378:metabolism; D010281:Parathyroid Hormone / Q000097:blood / Q000502:physiology*; D010282:Parathyroid Neoplasms / Q000097:blood; D011247:Pregnancy; D011262:Pregnancy Trimester, Second; D011863:Radioimmunoassay; D006435:Renal Dialysis; D012279:Rickets / Q000097:blood; D014807:Vitamin D / Q000502:physiology
D010281:Parathyroid Hormone; D014807:Vitamin D; D002116:Calcitonin; D008274:Magnesium; D002118:Calcium