Antagonistic effects of pemoline to colchicine and caffeine.
Pemoline, the constituent of Tradon, is able to slow down the decrease of the mitotic index caused by 0.1% caffeine in roots of Vicia faba, and mitotic aberrations are reduced. With 0.005% colchicine and 3 x 10(-4) g/ml pemoline, no metaphase-accumulation can be observed, and anaphase-disorder is delayed.
D002110:Caffeine / Q000037:antagonists & inhibitors* / Q000494:pharmacology; D003078:Colchicine / Q000037:antagonists & inhibitors* / Q000494:pharmacology; D008938:Mitosis / Q000187:drug effects*; D010389:Pemoline / Q000494:pharmacology*; D010944:Plants / Q000378:metabolism*
D002110:Caffeine; D010389:Pemoline; D003078:Colchicine