The objective and timing of drug disposition studies, appendix IV. Phenylbutazone formulations: in vitro dissolution and in vivo performance.
Human plasma level studies were conducted on various phenylbutazone formulations. The resultant data indicated that the nature of the formulation had a marked influence on the rate of phenylbutazone absorption. An in vitro dissolution rate apparatus was employed in an attempt to predict potential absorption of phenylbutazone from a given formulation. Based upon the in vitro-in vivo correlation, a new phenylbutazone tablet product was developed which produced a complete and more rapid absorption of the drug.
D000328:Adult; D002214:Capsules; D006801:Humans; D010653:Phenylbutazone / Q000008:administration & dosage* / Q000097:blood / Q000494:pharmacology; D012995:Solubility; D013607:Tablets; D013608:Tablets, Enteric-Coated; D013997:Time Factors
D002214:Capsules; D013607:Tablets; D013608:Tablets, Enteric-Coated; D010653:Phenylbutazone