[The effect of pretreatment with enzyme inducers on the acute toxicity of DDT (1, 1-bis-(p-chlorophenyl)-2,2,2-trichloroethane) in rats].
A study was undertaken to investigate the influence of various hepatic enzyme inducers on the acute toxicity of the organohalogenated insecticide DDT. Adult female rats were pretreated with sodium phenobarbital (50 mg/kg/day during 5 days), 3-methylocholanthrene (20 mg/kg/day during 3 days), and norethandrolone (20 mg/kg/day during 14 days), and were then given 150 mk/kg of DDT per os. Phenobarbital was shown to lower the toxicity of DDT, norethandrolone had the opposite effect, and 3-methylcholanthrene was without any significant effect. After a phenobarbital pretreatment, the cerebral concentration of DDT was lowered, possibly as a result of an increased biotransformation of DDT to DDD in the liver. On the other hand, norethandrolone did not appear to modify the hepatic conversion of DDT to DDD, nor the cerebral concentration of DDT. Further studies are needed to explain the potentiating effect of norethandrolone on the acute toxicity of DDT.
D000818:Animals; D001921:Brain / Q000187:drug effects / Q000378:metabolism; D003634:DDT / Q000097:blood / Q000378:metabolism / Q000633:toxicity*; D004347:Drug Interactions; D004790:Enzyme Induction / Q000187:drug effects; D005260:Female; D008099:Liver / Q000187:drug effects / Q000378:metabolism; D008748:Methylcholanthrene / Q000494:pharmacology*; D009639:Norethandrolone / Q000494:pharmacology*; D010634:Phenobarbital / Q000494:pharmacology*; D051381:Rats
D008748:Methylcholanthrene; D003634:DDT; D009639:Norethandrolone; D010634:Phenobarbital
Influence de prétraitements avec certains inducteurs enzymatiques sur la toxicité aiguë du DDT (1,1-bis-(p-chlorophényl)-2,2,2-trichloroéthane) chez le rat