title: [Influence of an acute hypercalcemia on the gastric secretion in duodenal ulcer, peptic ulcer of the jejunum and Zollinger-Ellison syndrome].
abstract: In 36 patients with ulcer without Zollinger-Ellison-syndrome (25 patients with recurrent duodenal ulcer, 11 with an ulcus pepticum jejuni after B II-resection of the stomach) and 2 patients suffering from ulcus pepticum jejuni with an ascertained gastrinoma the secretion of acid was compared after stimulation of pentagstrin (6 mug/kg) and calcium (4 mg Ca++/kg/h). The secretion of hydrochloric acid was statistically significantly stimulated in all patients suffering from ulcer by the hypercalcaemia (increase of the serum calcium concentration from 5.0 +/- 0.3 mval/1 to 6.2 +/- 0.8 mval/1). But in patients suffering from ulcer with gastrinoma the stimulatory effect was larger than in such patients without autonomous source of gastrin: the calcium-stimulated secretion of hydrochloric acid was on the average in cases of duodenal ulcer 40% (2 to 68%), in the ulcera peptica jejuni 47% (17 to 75%), in the 4 comparative examinations of the two patients with Zollinger-Ellison-syndrome, however, always more than 100% (106 to 177%) of the pentagastrin-stimulated peak secretion. The comparative test of the pentagastrin and calcium-stimulated secretion of hydrochloric acid could be a help for the proof of autonomous places of the formation of gastrin.
mesh_terms: D000208:Acute Disease; D004381:Duodenal Ulcer / Q000503:physiopathology*; D005750:Gastric Juice / Q000378:metabolism*; D005755:Gastrins / Q000378:metabolism; D006801:Humans; D006934:Hypercalcemia / Q000503:physiopathology*; D007583:Jejunum / Q000503:physiopathology; D010437:Peptic Ulcer / Q000503:physiopathology*; D012008:Recurrence; D015043:Zollinger-Ellison Syndrome / Q000503:physiopathology*
chemical_list: D005755:Gastrins
vernacular_title: Der Einfluss einer akuten Hyperkalzämie auf die Magensekretion beim Ulcus duodeni, Ucus pepticum jejuni und Zollinger-Ellison-Sydrome