Characteristics of an ovine herpesvirus associated with pulmonary adenomatosis (jaagsiekte) in sheep.
The isolation of an ovine herpesvirus from a cell culture of an adenomatous sheep lung is reported, confirming previous observations of a possible association of a herpesvirus with this tumour. Some growth properties and morphological characteristics of the virus are described, as well as serological data supporting a possible relationship between tumour and virus. Attempts to produce jaagsiekte by intratracheal injection of virus into lambs were unsuccessful, suggesting that a second factor may be involved inthe oncogenic process possibly similar to that proposed for the well-known EBV-Burkitt's lymphoma system.
D000818:Animals; D000914:Antibodies, Viral / Q000032:analysis; D002460:Cell Line; D006564:Herpesviridae / Q000302:isolation & purification* / Q000472:pathogenicity / Q000648:ultrastructure; D008168:Lung / Q000382:microbiology; D011648:Pulmonary Adenomatosis, Ovine / Q000209:etiology / Q000276:immunology / Q000382:microbiology*; D012756:Sheep; D014776:Virus Cultivation
D000914:Antibodies, Viral