[Effect of an inhibitor of a trypsin-like enzyme on the degradation of liver proteins under normal conditions and in thermic burns].
Degradation of proteins in liver tissue slices, estimated by liberation of 14C-glycine, was increased in the animals which were subjected to burns. The cathepsin D activity was found to be simultaneously increased in extracts of the liver tissue. In burnt rats, administered with an inhibitor of trypsin-like enzymes (contrical) during 8 days after the burning, the rates of protein degradation and the values of cathepsin D activity approached those characteristics for the normal animals. Addition of the inhibitor into incubation samples did not effect degradation of liver tissue proteins and the enzymatic activity.
D000818:Animals; D002056:Burns / Q000201:enzymology*; D002403:Cathepsins / Q000378:metabolism*; D005998:Glycine / Q000378:metabolism; D006023:Glycoproteins / Q000378:metabolism*; D008099:Liver / Q000201:enzymology / Q000378:metabolism*; D051381:Rats; D014361:Trypsin Inhibitors / Q000378:metabolism*
D006023:Glycoproteins; D014361:Trypsin Inhibitors; D002403:Cathepsins; D005998:Glycine
Deĭstvie ingibitora tripsinopodobnykh fermentov na raspad belkov pecheni v norme i pri termicheskikh ozhogakh