[Behavior of intestinal motility and serum gastrin level during prostaglandin administration in acute mechanical ileus of the rabbit].
In 29 rabbits the action of PGF2 alpha and PGE2 was compared with prostigmine in a mechanical ileus model. PGE2 produces no therapeutical effect. PGF2 alpha delivered a significant increase of intraluminal intestinal pressure and of the amplitudes of peristalsis, lasting for about 5 minutes, whereas prostigmine made a long lasting significant enlargment of the amplitudes of peristalsis without any modification of intraluminal pressure. Serum gastrin levels increased after application of PGE2 and PGF2 alpha and remained constant after prostigmine. A possible way of action of PG's in the gastrointestinal tract is discussed, based on experiments concerning PG-application after different periods of time.
D000208:Acute Disease; D000818:Animals; D005755:Gastrins / Q000097:blood*; D005769:Gastrointestinal Motility / Q000187:drug effects*; D007415:Intestinal Obstruction / Q000097:blood* / Q000188:drug therapy / Q000503:physiopathology*; D008365:Manometry; D011453:Prostaglandins / Q000494:pharmacology* / Q000627:therapeutic use; D011817:Rabbits
D005755:Gastrins; D011453:Prostaglandins
Verhalten von Darmmotilität und Serumgastrinspiegel unter Prostaglandingabe beim frischen mechanischen Ileus des Kaninchens