Pentobarbital sodium and chromosome abnormalities in rabbit blastocysts.
Female rabbits were injected with pentobarbital sodium at 1/4 h or 6 h post coitum. A slight delay in oocyte maturation was evident in animals killed at 17 h pc, however, zygote development appeared normal by 24 h pc. At 6 days pc, a greater frequency of chromosomally abnormal blastocysts was found in animals injected with pentobarbital than in control rabbits.
D000818:Animals; D001755:Blastocyst / Q000187:drug effects; D002869:Chromosome Aberrations / Q000139:chemically induced*; D025063:Chromosome Disorders; D005260:Female; D005306:Fertilization / Q000187:drug effects; D005865:Gestational Age; D010060:Ovulation / Q000187:drug effects; D010424:Pentobarbital / Q000494:pharmacology; D011247:Pregnancy; D011817:Rabbits
D010424:Pentobarbital