Acetylcholine storage and its stabilization by morphine.
Acetylcholine binds to adenosine-triphosphate in vitro by ionic bonds between the ammonium ion and the phosphate, as shown by nuclear magnetic resonance data. This binding is further increased by morphine, which also binds to adenosine-triphosphate, but not to acetylcholine. The opiate antagonists naloxone and naltrexone show similar effects. This may offer a molecular explanation of acetylcholine release impairment in nerve endings by narcotic analgestic drugs.
D000109:Acetylcholine / Q000378:metabolism*; D000255:Adenosine Triphosphate / Q000378:metabolism / Q000494:pharmacology; D000818:Animals; D055598:Chemical Phenomena; D002621:Chemistry; D066298:In Vitro Techniques; D007700:Kinetics; D009682:Magnetic Resonance Spectroscopy; D009020:Morphine / Q000494:pharmacology*; D009270:Naloxone / Q000494:pharmacology; D009271:Naltrexone / Q000494:pharmacology; D012965:Sodium Chloride / Q000494:pharmacology; D013050:Spectrometry, Fluorescence; D013574:Synaptosomes / Q000187:drug effects / Q000378:metabolism
D009270:Naloxone; D012965:Sodium Chloride; D009271:Naltrexone; D009020:Morphine; D000255:Adenosine Triphosphate; D000109:Acetylcholine