The effects of serotonin injections into the locus coeruleus on ponto geniculo occipital (PGO) waves and cortical EEG pattern in cats.
Reserpine injected iv at 0-8--1-0 mg/kg doses induced continuous ponto-geniculo-occipital (PGO-like) waves in immobilized cats. Both 5-HT and quipazine injected into the locus coeruleus decreased the frequency of reserpine-induced PGO waves and increased cortical synchronization. Suppression of PGO activity persisted for 15--30 min whilst synchronizing effects lasted much longer. Methysergide increased the frequency of PGO activity but caused no clear changes in the EEG pattern.
D000818:Animals; D000928:Antidepressive Agents / Q000494:pharmacology; D002415:Cats; D003344:Cortical Synchronization; D004569:Electroencephalography; D005829:Geniculate Bodies / Q000502:physiology*; D007276:Injections, Intraventricular; D008238:Lysergic Acid Diethylamide / Q000494:pharmacology; D008297:Male; D008784:Methysergide / Q000494:pharmacology; D009778:Occipital Lobe / Q000502:physiology*; D010879:Piperazines / Q000494:pharmacology; D011804:Quinolines / Q000494:pharmacology; D012110:Reserpine / Q000494:pharmacology; D012701:Serotonin / Q000008:administration & dosage / Q000494:pharmacology*; D013997:Time Factors
D000928:Antidepressive Agents; D010879:Piperazines; D011804:Quinolines; D012701:Serotonin; D012110:Reserpine; D008238:Lysergic Acid Diethylamide; D008784:Methysergide