title: The effect of somatostatin on release and insulinotropic action of gastric inhibitory polypeptide.
abstract: Studies were carried out in conscious dogs in which the effect of intravenous somatostatin on immunoreactive gastric inhibitory polypeptide (IR-GIP) release was investigated. In addition, the inhibitory action of somatostatin on the insulin response to pure porcine GIP was assessed. Intravenous administration of somatostatin resulted in a delayed IR-GIP and immunoreactive insulin (IRI) response to oral glucose. Somatostatin also delayed the IR-GIP response to the ingestion of fat. In both types of experiments, initial depression of IRI levels was followed by a sharp rise in IRI release. Intravenous infusion of somatostatin produced 80% inhibition of the IRI response to pure porcine GIP. It was concluded that somatostatin inhibits the physiological release of IR-GIP and the insulinotropic action of exogenous porcine GIP.
mesh_terms: D000818:Animals; D004285:Dogs; D005223:Fats / Q000494:pharmacology; D005260:Female; D005768:Gastrointestinal Hormones / Q000378:metabolism / Q000494:pharmacology*; D005947:Glucose / Q000378:metabolism; D007328:Insulin / Q000378:metabolism*; D000078790:Insulin Secretion; D008297:Male; D010179:Pancreas / Q000378:metabolism; D010455:Peptides / Q000378:metabolism / Q000494:pharmacology*; D013004:Somatostatin / Q000494:pharmacology*; D013268:Stimulation, Chemical; D013552:Swine; D013997:Time Factors
chemical_list: D005223:Fats; D005768:Gastrointestinal Hormones; D007328:Insulin; D010455:Peptides; D013004:Somatostatin; D005947:Glucose