Further studies of photoaugmentation in humans: phototoxic reactions.
The addition of modest amounts of long ultraviolet light (UV-A) to 1/2 minimal erythema dose (MED) of sunburning irradiation (UV-B) produced erythema visible at 24 hr, the prototype of the photoaugmentation phenomenon. The results were the same whether UV-A was given before or after UV-B. Photoaugmentation could be demonstrated after an inverval of 6 hr between doses, but not after 1 day. Photoaugmentation has also been demonstrated clinically and histologically with two topical photosensitizers, coal tar and 8-methoxy-psoralen.
D000328:Adult; D003033:Coal Tar / Q000009:adverse effects; D004890:Erythema / Q000209:etiology*; D006801:Humans; D008297:Male; D008730:Methoxsalen / Q000009:adverse effects; D010787:Photosensitivity Disorders / Q000209:etiology*; D013471:Sunburn / Q000209:etiology; D014466:Ultraviolet Rays / Q000009:adverse effects*
D003033:Coal Tar; D008730:Methoxsalen