[The mechanism of nonachlazine on cardiac activity and blood supply].
Nonachlazine (10 mg/kg intravenously) exerted a two-phase influence on the heart activity. The short phase of the weakening of the heart activity gave place to the intensive increase in the cardiac output and the contractility of the myocardium. An increase in the blood supply and heart activity coincided in time with the accumulation of the quantity of noradrenaline and with increase in the phosphorylase "a" activity. Beta-adrenoblockers prevented the development of the effect in question. It is assumed that the efficacy of nonachlazine during ischemic heart disease was connected with its capacity to activate the adrenergic mechanisms of the glycogenolysis regulation leading to the switching of the myocardial metabolism to the anaerobic route of energy release.
D002302:Cardiac Output / Q000187:drug effects; D002395:Catecholamines / Q000378:metabolism*; D004837:Epinephrine / Q000378:metabolism; D006321:Heart / Q000187:drug effects*; D009200:Myocardial Contraction / Q000187:drug effects; D009206:Myocardium / Q000201:enzymology; D009638:Norepinephrine / Q000378:metabolism; D010640:Phenothiazines / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D006005:Phosphorylases / Q000378:metabolism; D010879:Piperazines / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D011433:Propranolol / Q000494:pharmacology; D014665:Vasodilator Agents / Q000037:antagonists & inhibitors / Q000494:pharmacology*
D002395:Catecholamines; D010640:Phenothiazines; D010879:Piperazines; D014665:Vasodilator Agents; D011433:Propranolol; D006005:Phosphorylases; D009638:Norepinephrine; D004837:Epinephrine
K mekhanizmu deĭstviia nonakhlazina na krovosnabzhenie i deiatel'nost' serdtsa