Prostaglandin levels in endometrial jet wash specimens in patients with dysmenorrhea before and after indomethacin therapy.
A patient with functional primary dysmenorrhea of over two years duration was subjected to the endometrial jet wash technique during the period of active menstrual flow. Prostaglandin F analysis of the jet washings revealed significantly elevated levels during menstruation over normal control levels. Following indomethacin therapy, jet wash prostaglandin F levels were dramatically reduced and the patient became asymptomatic. A cause and effect relationsship between prostaglandin F and dysmenorrhea is suggested by these studied.
D000328:Adult; D004412:Dysmenorrhea / Q000188:drug therapy*; D004717:Endometrium / Q000378:metabolism*; D005260:Female; D006801:Humans; D007213:Indomethacin / Q000627:therapeutic use*; D008598:Menstruation; D011460:Prostaglandins F / Q000378:metabolism*; D007507:Therapeutic Irrigation
D011460:Prostaglandins F; D007213:Indomethacin