[Action of gonadotropins on androgen synthesis by embryonic testes of mouse and rat].
Testes from mouse and rat embryos were cultured in vitro in the presence of 14C-sodium acetate and luteinizing hormone or chorionic gonadotrophin. There is an increase in testosterone and androstenedione synthesis from sodium acetate under both treatments. Sensitivity to gonadotrophins exists already at a relatively early stage, when the testis, through testosterone secretion, is building up the genital tract. But the role of the hypophysis in normal androgen secretion will have to be proven.
D000085:Acetates / Q000378:metabolism; D000728:Androgens / Q000096:biosynthesis*; D000735:Androstenedione / Q000096:biosynthesis; D000818:Animals; D006063:Chorionic Gonadotropin / Q000494:pharmacology; D006062:Gonadotropins / Q000494:pharmacology*; D007986:Luteinizing Hormone / Q000494:pharmacology; D008297:Male; D051379:Mice; D009924:Organ Culture Techniques; D051381:Rats; D013268:Stimulation, Chemical; D013737:Testis / Q000187:drug effects / Q000196:embryology* / Q000378:metabolism; D013739:Testosterone / Q000096:biosynthesis
D000085:Acetates; D000728:Androgens; D006063:Chorionic Gonadotropin; D006062:Gonadotropins; D013739:Testosterone; D000735:Androstenedione; D007986:Luteinizing Hormone
Effet des gonadotrophines sur la synthèse d'androgènes par les testicules embryonnaires de souris et de rat