title: A model of NaCl and water flow through paracellular pathways of renal proximal tubules.
abstract: To explain how hydrostatic pressure differences between tubule lumen and interstitium modulate isotonic reabsorption rates, we developed a model of NaCl and water flow through paracellular pathways of the proximal tubule. Structural elements of the model are a tight junction membrane, an intercellular channel whose walls transport NaCl actively at a constant rate, and a basement membrane. Equations of change were derived for the channel, boundary conditions were formulated from irreversible thermodynamics, and a pressure-area relationship typical of thin-walled tubing was assumed. The boundary value problem was solved numerically. The principal conclusions are: 1) channel NaCl concentration must remain within a few mOsm of isotonic values for reabsorption rates to be modulated by transtubular pressure differences known to affect this system: 2) basement membrane and channel wall parameters determine reabsorbate tonicity; tight junction parameters affect the sensitivity of reabsorption to transmural pressure; 3) channel NaCl concentration varies inversely with transmural pressure difference; this concentration variation controls NaCl diffusion through the tight junction; 4) modulation of NaCl diffusion through the tight junction controls the rate of isotonic reabsorption; modulation of water flow can increase sensitivity to transmural pressure; 5) no pressure-induced change in permeability of the tight junction or basement membrane is needed for pressure to modulate reabsorption; and 6) system performance is indifferent to the distribution of active transport sites, to the numerical value of the compliance function, and to the relationship between lumen and cell pressures.
mesh_terms: D001485:Basement Membrane / Q000378:metabolism; D001693:Biological Transport, Active; D002463:Cell Membrane Permeability; D004058:Diffusion; D006874:Hydrostatic Pressure; D007365:Intercellular Junctions / Q000378:metabolism; D007687:Kidney Tubules, Proximal / Q000378:metabolism* / Q000502:physiology; D008433:Mathematics; D008954:Models, Biological; D009994:Osmolar Concentration; D009997:Osmotic Pressure; D011312:Pressure; D012965:Sodium Chloride / Q000378:metabolism*; D014867:Water / Q000378:metabolism*; D014882:Water-Electrolyte Balance
chemical_list: D014867:Water; D012965:Sodium Chloride