Effectiveness of prostaglandin E1 and procarbazine hydrochloride in prolonging the survival of vascularized cardiac hamster-to-rat xenograft.
The immunosuppressive effects of prostaglandin E1 and procarbazine hydrochloride were compared in a vascularized organ xenograft model. Hamster-to-rat cardiac grafts were used. Both procarbazine hydrochloride and prostaglandin E1 prolonged survival of the xenograft. Prostaglandin E1 had the additional feature of coincident suppression of hemagglutination titer to hamster red cells. Prostaglandin E1 was somewhat less effective than procarbazine hydrochloride.
D000818:Animals; D006224:Cricetinae; D006084:Graft Rejection; D016027:Heart Transplantation; D006386:Hemagglutination Tests; D007165:Immunosuppression Therapy; D009206:Myocardium / Q000473:pathology; D011344:Procarbazine / Q000627:therapeutic use*; D011458:Prostaglandins E / Q000627:therapeutic use*; D051381:Rats; D013997:Time Factors; D014183:Transplantation, Heterologous
D011458:Prostaglandins E; D011344:Procarbazine