The effects of drugs on accumulation and release of catecholamines in rat brain slices.
Pretreatment of rats with reserpine decreased the uptake and release of labelled NE and DA in rat slices. MAO inhibition with nialamide partially antagonized the effects of reserpine, but nialamide itself decreased the release of labelled DA. Treatment of brain slices in vitro with phenoxybenzamine or desmethylimipramine inhibited uptake of catecholamines, and affected spontaneous and electrically-stimulated release in a manner consistent with the existence of an alpha-receptor-mediated feedback regulation of release at both NE and DA nerve terminals. The effect of phenoxybenzamine on stimulated release was observed to be dependent on stimulation rate.
D000818:Animals; D001921:Brain / Q000187:drug effects / Q000378:metabolism*; D002395:Catecholamines / Q000378:metabolism*; D002540:Cerebral Cortex / Q000378:metabolism; D003342:Corpus Striatum / Q000378:metabolism; D003891:Desipramine / Q000494:pharmacology; D066298:In Vitro Techniques; D009526:Nialamide / Q000494:pharmacology; D010643:Phenoxybenzamine / Q000494:pharmacology; D051381:Rats; D012110:Reserpine / Q000494:pharmacology; D013997:Time Factors
D002395:Catecholamines; D010643:Phenoxybenzamine; D012110:Reserpine; D009526:Nialamide; D003891:Desipramine