Experimental ischaemia of the small intestine. Effect of antibiotic and antithrombotic drugs on the mucosal exchange circulation.
Factors of decisive importance for the fate of the intestine following circulatory occlusion incluse the bacterial flora of the intestine, intravascular thrombosis peripheral to the level of occlusion, and the capacity of the collateral circulation. Standardized ischaemia of the small intestine was produced in the rat by ligation of a given number of mesentric end arcades. The passive absorption of radioiodide from a defined, central loop within the ischaemic intestinal segment-as an expression of the exchange circulation of the intestinal mucosa-was determined 14 days after induction of the ischaemia. Different forms of treatment were studied. In Sprague-Dawley rats the effect of heparin, oxitetracycline (OCD) and a combination of these two drugs was examined both concerning the survival of the animals and with regard to the available exchange circulation in the mucosa of the ischaemic intestinal segment. The survival frequency was increased in all treatment groups. The exchange circulation in the ischaemic segment was improved significantly by ODC-treatment and by treatment with heparin and ODC combined. Treatment with heparin alone gave no improvement of the mucosal circulation.
D000818:Animals; D001777:Blood Coagulation; D001835:Body Weight / Q000187:drug effects; D004338:Drug Combinations; D006400:Hematocrit; D006493:Heparin / Q000494:pharmacology*; D007413:Intestinal Mucosa / Q000098:blood supply* / Q000187:drug effects; D007421:Intestine, Small / Q000033:anatomy & histology / Q000098:blood supply*; D007511:Ischemia / Q000401:mortality; D008297:Male; D008833:Microcirculation / Q000187:drug effects*; D010118:Oxytetracycline / Q000494:pharmacology*; D051381:Rats
D004338:Drug Combinations; D006493:Heparin; D010118:Oxytetracycline