Effect of fatty acids on the stimulated gastric secretion in man.
Solutions and emulsions of sodium or potassium salts in a series of saturated fatty acids from C8 to C18 were given in a dose of 0.5 g intraduodenally to healthy males or patients with healed duodenal ulcer. A double-lumen Sarles tube with a balloon placed in the proximal duodenum was used. The substances were instilled after a plateau of gastric acid secretion induced by a continuous infusion of pentagastrin was reached. In order to exclude unspecific effects, the test solutions were adjusted to a pH around 7.0 and to plasma isosmolality. Compared with the other tested substances, the emulsion of 0.5 g sodium-oleate was the most effective in inhibiting the stimulated gastric acid secretion. Sodium caprinate and caprylate had a considerable, but smaller effect than oleic acid on the secretory plateau. Palmitate and laurate provoked only a slight decrease in acid secretion. Myristate was ineffective. These results could suggest that different receptors are responsible for fat-induced inhibition of the gastric acid secretion.
D000328:Adult; D002210:Caprylates / Q000008:administration & dosage / Q000494:pharmacology; D003652:Decanoic Acids / Q000008:administration & dosage / Q000494:pharmacology; D004386:Duodenum; D005227:Fatty Acids / Q000494:pharmacology*; D005750:Gastric Juice / Q000378:metabolism*; D006801:Humans; D007267:Injections; D007850:Lauric Acids / Q000008:administration & dosage / Q000494:pharmacology; D008297:Male; D008875:Middle Aged; D009829:Oleic Acids / Q000008:administration & dosage / Q000494:pharmacology; D010169:Palmitic Acids / Q000008:administration & dosage / Q000494:pharmacology; D010418:Pentagastrin / Q000494:pharmacology; D013229:Stearic Acids / Q000008:administration & dosage / Q000494:pharmacology
D002210:Caprylates; D003652:Decanoic Acids; D005227:Fatty Acids; D007850:Lauric Acids; D009829:Oleic Acids; D010169:Palmitic Acids; D013229:Stearic Acids; D010418:Pentagastrin