Cholinomimetic teratogens. II. Interaction with inorganic ions.
Treatment of chicken embryos after 96 h of incubation showed that the teratogenic activity of the cholinomimetic compounds carbachol, neostigmine, decamethonium, and tetramethylammonium is reduced in the presence of calcium acetate. Similarly, supplementation with potassium acetate reduced the teratogenicity of carbachol and tetramethylammonium.
D000014:Abnormalities, Drug-Induced; D000818:Animals; D002118:Calcium / Q000494:pharmacology*; D002217:Carbachol / Q000494:pharmacology; D002642:Chick Embryo / Q000187:drug effects; D003650:Decamethonium Compounds / Q000494:pharmacology; D004347:Drug Interactions; D007474:Ion Exchange; D009388:Neostigmine / Q000494:pharmacology; D009469:Neuromuscular Junction / Q000187:drug effects; D010277:Parasympathomimetics / Q000494:pharmacology*; D011188:Potassium / Q000494:pharmacology*; D000644:Quaternary Ammonium Compounds / Q000494:pharmacology; D011950:Receptors, Cholinergic / Q000187:drug effects; D013723:Teratogens / Q000494:pharmacology*; D013997:Time Factors
D003650:Decamethonium Compounds; D010277:Parasympathomimetics; D000644:Quaternary Ammonium Compounds; D011950:Receptors, Cholinergic; D013723:Teratogens; D009388:Neostigmine; D002217:Carbachol; D011188:Potassium; D002118:Calcium