[Effect of neuroleptics and antidepressants on the process of gamma-aminobutyric acid-H3 uptake by isolated rat brain nerve endings].
The effects of phenothiazine neuropleptics--chlorpromazine, trifluoperazine, fluphenazine and of antidepressants-imipramine and phthoracizine on the GABA-H3 accumulation by synaptosomes of the rat cerebral cortex were studied. All neuroleptics were found to inhibit the process of neurotransmitter uptake by the brain synaptosomes. Antidepressants were less potent. Chlorpromazine had the highest inhibitory effect on GABA uptake and phthoracizine--the lowest. It is suggested that the influence of neurolptics on GABA uptake could play a certain role in the mode of a synaptic action of these drugs.
D000613:Aminobutyrates / Q000378:metabolism*; D000818:Animals; D000928:Antidepressive Agents / Q000494:pharmacology; D002540:Cerebral Cortex / Q000187:drug effects / Q000378:metabolism*; D002746:Chlorpromazine / Q000494:pharmacology; D005476:Fluphenazine / Q000494:pharmacology; D007099:Imipramine / Q000494:pharmacology; D066298:In Vitro Techniques; D008297:Male; D010640:Phenothiazines / Q000494:pharmacology; D011619:Psychotropic Drugs / Q000494:pharmacology*; D051381:Rats; D013574:Synaptosomes / Q000187:drug effects / Q000378:metabolism*; D014268:Trifluoperazine / Q000494:pharmacology; D005680:gamma-Aminobutyric Acid / Q000378:metabolism*
D000613:Aminobutyrates; D000928:Antidepressive Agents; D010640:Phenothiazines; D011619:Psychotropic Drugs; D014268:Trifluoperazine; D005680:gamma-Aminobutyric Acid; D007099:Imipramine; D005476:Fluphenazine; D002746:Chlorpromazine
Vliianie neĭroleptikov i antidepressantov na protsess zakhvata gamma-aminomaslianoĭ kisloty-H3 izolirovannymi nervnymi okonchaniiami mozga krysy