[Behavior of lactate and pyruvate as well as lactate/pyruvate quotient in blood in human thyroid gland disorders].
The pyruvate and lactate levels in blood of patients with thyroid diseases were investigated and also the lactate/pyruvate ratio. The levels of pyruvate were significantly elevated in hyperthyreotic patients in comparison with the euthyreotic control group; in hypothyreotic patients the levels were lowered. Only in hypothyreotic patients the lactate level was slightly increased. In all the three groups the lactate/pyruvate ratio showed highly significant differences, in hyperthyreosis decreased, in hypothyreosis increased in comparison with normal subjects. In patients suffering from hyperthyreosis as well as in cases with euthyreotic goitre we found similar pyruvate levels and lactate/pyruvate ratios as in the hyperthyreotic cases. It seems likely to be an inexpected effect of the treatment with pure triiodothyronine or triiodothyronine/thyroxine in combination.
D000293:Adolescent; D000328:Adult; D000368:Aged; D006042:Goiter / Q000097:blood; D006801:Humans; D006980:Hyperthyroidism / Q000097:blood; D007037:Hypothyroidism / Q000097:blood; D007773:Lactates / Q000097:blood*; D008875:Middle Aged; D011773:Pyruvates / Q000097:blood*; D011863:Radioimmunoassay; D013959:Thyroid Diseases / Q000097:blood*
D007773:Lactates; D011773:Pyruvates
Zum Verhalten von Laktat und Pyruvat sowie des Laktat/Pyruvat-Quotienten im Blut bei Schilddrüsenfunktionsstörungen des Menschen