Effect of cortexolone on the feedback action of dexamethasone.
Cortexolone in a dose of 1 mg/100 g body wt., administered to rats prior to dexamethasone, prevented dexamethasone from suppressing stress-induced ACTH-release without interfering with the effect of dexamethasone on the resting plasma corticosterone level.
D015065:17-Hydroxycorticosteroids / Q000494:pharmacology*; D000818:Animals; D003345:Corticosterone / Q000097:blood / Q000378:metabolism*; D003350:Cortodoxone / Q000494:pharmacology*; D003907:Dexamethasone / Q000494:pharmacology*; D005246:Feedback; D006632:Histamine / Q000494:pharmacology; D008297:Male; D051381:Rats
D015065:17-Hydroxycorticosteroids; D003907:Dexamethasone; D006632:Histamine; D003345:Corticosterone; D003350:Cortodoxone