title: Do one-hit chromosome exchanges exist? Dose-response relation for irradiated human lymphocytes.
abstract: It is demonstrated that the expectation of a quadratic dose-response relation for two-hit aberrations is not correct. In fact the theoretical curve is changed from near-quadratic to near-linear when the dose increases and fits well the experimental data on production of exchanges in human lymphocytes by radiation. The commonly used relation y = alphaD + betaD2 shows systematic deviations from the observed frequencies. Therefore, no reason exists to postulate some fraction of exchanges to be produced by a one-hit mechanism.
mesh_terms: D002869:Chromosome Aberrations; D003037:Cobalt Radioisotopes; D004307:Dose-Response Relationship, Radiation; D005260:Female; D005720:Gamma Rays; D006801:Humans; D008214:Lymphocytes / Q000528:radiation effects*; D008297:Male; D011831:Radiation Genetics
chemical_list: D003037:Cobalt Radioisotopes