[Effects of cytochalasin B and colchicine on dental cytodifferentiation in vitro].
The effects of various concentrations of cytochalasin B and colchicine on the polarization of odontoblasts and ameloblasts of mouse tooth buds cultivated in vitro, were studies. It was shown that cytochalasin B, deside its action on the microfilaments, had important cytotoxic effects; dilatation of the odontoblast's processus, accumulation of secretory granules in the Golgi apparatus, dilatation of mitochondria, inhibition of polarization or depolarization of odontoblasts and ameloblasts. These modifications resulted chiefly from the lesion of microtubules which seem to play an important role in the polarization of the cells studies.
D000565:Ameloblasts / Q000187:drug effects* / Q000648:ultrastructure; D000818:Animals; D002454:Cell Differentiation / Q000187:drug effects; D003078:Colchicine / Q000494:pharmacology*; D003571:Cytochalasin B / Q000494:pharmacology*; D006056:Golgi Apparatus / Q000187:drug effects; D066298:In Vitro Techniques; D051379:Mice; D008870:Microtubules / Q000187:drug effects; D008928:Mitochondria / Q000187:drug effects; D009804:Odontoblasts / Q000187:drug effects* / Q000648:ultrastructure; D009805:Odontogenesis / Q000187:drug effects*
D003571:Cytochalasin B; D003078:Colchicine
Effets de la cytochalasine B et de la colchicine sur les cytodifférenciations dentaires in vitro