The influence of furosemide on the renal excretion of chloramphenicol and its metabolites.
Simultaneous administration of chloramphenicol and furosemide (10 mg i.v.) decreased urinary excretion of chloramphenicol but increased the excretion of its metabolites as aryl amines and total nitro compounds. These latter increases were directly related to Na excretion.
D000328:Adult; D002701:Chloramphenicol / Q000378:metabolism* / Q000652:urine; D005260:Female; D005665:Furosemide / Q000494:pharmacology*; D006801:Humans; D007444:Inulin / Q000652:urine; D007668:Kidney / Q000187:drug effects* / Q000502:physiology; D008297:Male; D008875:Middle Aged; D009318:Natriuresis
D002701:Chloramphenicol; D005665:Furosemide; D007444:Inulin