[Stimulation of protein synthesis in damaged cardiac muscle with RNA preparations].
Local injuries of the myocardium in rats induced by means of diathermocoagulation, as judged by the inclusion of C14-labelled aminoacids, stimulate the reparative biosynthesis of proteins in the injured and intact zones of the myocardium. Intraperitoneal administrations of a polymer RNA preparation from the cattle liver (6 mg/100 g of body weight) enhance the biosynthesis of proteins in the injured and intact zones of the myocardium 1.5--2--fold. The enzymatic hydrolyzate of RNA produces a less distinct stimulating effect. The authors believe that the RNA preparations may find their place in clinical stimulation of the reparative processes in the injured myocardium.
D000596:Amino Acids / Q000096:biosynthesis; D000818:Animals; D002250:Carbon Radioisotopes; D002417:Cattle; D005260:Female; D008110:Liver Extracts / Q000494:pharmacology* / Q000627:therapeutic use; D009203:Myocardial Infarction / Q000188:drug therapy / Q000378:metabolism*; D009206:Myocardium / Q000378:metabolism*; D014176:Protein Biosynthesis; D012313:RNA / Q000494:pharmacology* / Q000627:therapeutic use; D051381:Rats; D013268:Stimulation, Chemical
D000596:Amino Acids; D002250:Carbon Radioisotopes; D008110:Liver Extracts; D012313:RNA
Stimuliatsiia sinteza belka v povrezhdennoĭ serdechnoĭ myshtse preparatami RNK