Inhibition of Deamination of Arabinosylcytosine (NSC-63878) by Rhodium(II) Acetate.
The nobel metal "cage" complex, rhodium(II) acetate, was found to inhibit the deamination of the fraudulent nucleoside, arabinosylcytosine. Potent inhibition of a purified cytidine deaminase from mouse kidney was observed when either cytidine or arabinosylcytosine was used as substrate.
D000818:Animals; D003561:Cytarabine / Q000378:metabolism*; D003564:Cytidine Deaminase / Q000037:antagonists & inhibitors*; D007668:Kidney / Q000201:enzymology; D051379:Mice; D009700:Nucleoside Deaminases / Q000037:antagonists & inhibitors*; D012238:Rhodium / Q000494:pharmacology*
D003561:Cytarabine; D012238:Rhodium; D009700:Nucleoside Deaminases; D003564:Cytidine Deaminase