Failure of vasopressin to prevent the natruiretic and diuretic response to unilateral stimulation of carotid baroreceptors.
Unanesthetized rats treated with deoxycorticosterone acetate were continuously infused with a maximally effective dose of vasopressin (50 muU/min per 100 g). After a control period of 2 h the animals were subjected to a 2 h period of unilateral stimulation of the carotid baroreceptors. There was a large natriuretic response accompanied by diuresis and a fall in urine osmolality. It was concluded that neither the natriuretic nor the diuretic response could be explained by inhibition of vasopressin secretion. Analysis of kidney tissue indicated that the diuresis was associated with partial dissipation of the inner medullary concentration gradient.
D000818:Animals; D002346:Carotid Sinus / Q000187:drug effects / Q000502:physiology*; D003900:Desoxycorticosterone / Q000494:pharmacology; D004231:Diuresis / Q000187:drug effects*; D004558:Electric Stimulation; D007679:Kidney Medulla / Q000378:metabolism; D008297:Male; D009318:Natriuresis / Q000187:drug effects*; D009994:Osmolar Concentration; D011311:Pressoreceptors / Q000187:drug effects*; D051381:Rats; D013997:Time Factors; D014667:Vasopressins / Q000494:pharmacology*
D014667:Vasopressins; D003900:Desoxycorticosterone