Studies on thyroid therapy and thyroid function in depressive patients.
A number of cases of depressed patients have latent hypothyroidism, possibly due to hypothalamo-pituitary dysfunction, and become refractory to antidepressant drugs. The dramatic effect or thyroid medication combined with tricyclic antidepressants is often observed in such persistently depressed patients. This effect seems to pertain to the catecholamine hypothesis of depression, but this requires further elucidation.
D000328:Adult; D000929:Antidepressive Agents, Tricyclic / Q000627:therapeutic use; D003863:Depression / Q000188:drug therapy / Q000503:physiopathology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D013962:Thyroid (USP) / Q000627:therapeutic use*; D013961:Thyroid Gland / Q000503:physiopathology*; D013963:Thyroid Hormones / Q000627:therapeutic use*
D000929:Antidepressive Agents, Tricyclic; D013962:Thyroid (USP); D013963:Thyroid Hormones