Effects of S-8527 (1, 1-bis (4'-(1"-carboxy-1"-methylpropoxy) phenyl) cyclohexane), a new hypolipidemic compound, on platelet aggregation, adhesiveness and blood coagulation in rats.
Effects of S-8527 (1,1-bis[4'-(1"-carboxy-1"-methylpropoxy) phenyl] cyclohexane) on platelet aggregation, adhesiveness and blood coagulation were examined in rats. In animals maintained on a semisynthetic diet containing sucrose (62%) as the only carbohydrate source, platelet adhesiveness increased as compared with that in rats fed a normal chow pellet. Under these experimental conditions, oral dose of S-8527 (30-300 mg/kg) for 14 days decreased platelet adhesiveness and ADP-induced platelet aggregation, but did not decrease collagen-induced platelet aggregation. S-8527 also showed a slight but significant increase of R value of thrombelastograph. In rats which were fed a normal chow pellet oral dose of S-8527 for 14 days did not significantly affect the several tests of platelet function and blood coagulation. These results suggest that S-8527 normalizes the platelet function in a hyper-adhesive state, but does not affect the platelet function in a normal state.
D000244:Adenosine Diphosphate / Q000494:pharmacology; D000818:Animals; D001777:Blood Coagulation / Q000187:drug effects*; D002784:Cholesterol / Q000097:blood; D002994:Clofibrate / Q000494:pharmacology; D003094:Collagen / Q000494:pharmacology; D003510:Cyclohexanes / Q000494:pharmacology; D004032:Diet; D005340:Fibrinogen / Q000378:metabolism; D006016:Glycolates / Q000494:pharmacology*; D000960:Hypolipidemic Agents / Q000494:pharmacology; D008297:Male; D010642:Phenoxyacetates / Q000494:pharmacology*; D010973:Platelet Adhesiveness / Q000187:drug effects*; D010974:Platelet Aggregation / Q000187:drug effects*; D051381:Rats; D013395:Sucrose; D013916:Thrombelastography; D014280:Triglycerides / Q000097:blood
D003510:Cyclohexanes; D006016:Glycolates; D000960:Hypolipidemic Agents; D010642:Phenoxyacetates; D014280:Triglycerides; D013395:Sucrose; D000244:Adenosine Diphosphate; D005340:Fibrinogen; D003094:Collagen; D002784:Cholesterol; D002994:Clofibrate