The synergistic action of alpha-melanocyte-stimulating hormone and testosterone of the sebaceous, prostate, preputial, Harderian and lachrymal glands, seminal vesicles and brown adipose tissue in the hypophysectomized-castrated rat.
Alpha-Melanocyte-stimulating hormone was shown to act synergistically with testosterone to stimulate the sebaceous, prostate and the seminal vesicles in hypophys-ectomized-castrated rats. The sebaceous glands differed from the other three organs in that alpha-MSH not only acted synergistically, but also had a significant effect which was independent of the presence of exogenous testosterone. The response of the brown adipose tissue to testerone, considerably reduced by hypophysectomy, was not restored by alpha-MSH. The Harderian and lachrymal glands were also pituitary-dependent and their weights in hypophysectomized-castrated rats were not restored by alpha-MSH.
D002001:Adipose Tissue, Brown / Q000187:drug effects*; D000311:Adrenal Glands / Q000187:drug effects; D000818:Animals; D002369:Castration; D004357:Drug Synergism; D005837:Genitalia, Male / Q000187:drug effects*; D006243:Harderian Gland / Q000187:drug effects; D007016:Hypophysectomy; D007765:Lacrimal Apparatus / Q000187:drug effects*; D008297:Male; D009074:Melanocyte-Stimulating Hormones / Q000494:pharmacology*; D009929:Organ Size / Q000187:drug effects; D010413:Penis / Q000187:drug effects; D010902:Pituitary Gland / Q000502:physiology*; D010903:Pituitary Gland, Anterior / Q000502:physiology*; D011467:Prostate / Q000187:drug effects; D051381:Rats; D012627:Sebaceous Glands / Q000187:drug effects; D012629:Sebum / Q000378:metabolism; D012669:Seminal Vesicles / Q000187:drug effects; D013737:Testis / Q000502:physiology*; D013739:Testosterone / Q000494:pharmacology*
D013739:Testosterone; D009074:Melanocyte-Stimulating Hormones