title: Molecular connectivity. I: Relationship to nonspecific local anesthesia.
abstract: A very significant linear correlation was found between a recently proposed connectivity index and molecular polarizability, cavity surface areas calculated for water solubility of alcohols and hydrocarbons, and biological potencies of nonspecific local anesthetics. The simplicity of calculation of the index from the connectivity in the molecular skeleton, together with the very significant correlation, indicates its practical value.
mesh_terms: D000779:Anesthetics, Local; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D012997:Solvents; D013329:Structure-Activity Relationship; D013816:Thermodynamics
chemical_list: D000779:Anesthetics, Local; D012997:Solvents