title: Electron microscopic and cytochemical study of the vacuoles of regenerating renal tubular cells.
abstract: The structure and acid phosphatase activity of vacuoles observed in regenerating proximal renal tubules were examined ultrastructurally. The sequestration and degradation of organelles were followed in the vacuoles, which obtain the acid phosphatase presumably from the lysosomes, and the limiting membrane of which originates from the endoplasmic reticulum. The vacuoles are regarded as autophagic vacuoles. Their appearance is correlated with the commencing differentiation of the dedifferentiated regenerating cells, which have similar regenerative phenomena.
mesh_terms: D000135:Acid Phosphatase / Q000032:analysis; D000818:Animals; D007673:Kidney Cortex Necrosis / Q000139:chemically induced; D007684:Kidney Tubules / Q000502:physiology / Q000648:ultrastructure*; D007687:Kidney Tubules, Proximal / Q000201:enzymology; D008247:Lysosomes / Q000201:enzymology; D008297:Male; D051381:Rats; D012038:Regeneration; D014617:Vacuoles / Q000648:ultrastructure
chemical_list: D000135:Acid Phosphatase