title: Bulking agents in the treatment of obesity.
abstract: The effect of two bulk-forming appetite depressants, methylcellulose and gum guar, on food intake has been studied in 11 (4 male, 7 female) healthy volunteers--3 of whom were overweight. 10 g of active ingredient were given in two equal doses daily for periods of 1 week of each agent. Individually weighed dietary intakes were obtained over four consecutive weeks; the first and third weeks were without medication. Both gum guar and methylcellulose were equally effective in reducing appetite by 10%.
mesh_terms: D000328:Adult; D001067:Appetite Depressants; D001835:Body Weight; D005260:Female; D005685:Galactans; D006801:Humans; D008297:Male; D008351:Mannans; D008747:Methylcellulose / Q000627:therapeutic use*; D009765:Obesity / Q000188:drug therapy*; D053149:Plant Gums; D011134:Polysaccharides / Q000627:therapeutic use*
chemical_list: D001067:Appetite Depressants; D005685:Galactans; D008351:Mannans; D053149:Plant Gums; D011134:Polysaccharides; D008747:Methylcellulose; C007894:guar gum