title: Sister chromatid exchanges--a sensitive assay of agents damaging human chromosomes.
abstract: Sister chromatid exchange frequencies in human lymphocyte chromosomes are greatly increased by alkylating agents, but ionizing radiation has little if any such effect. Scoring these exchanges may provide a useful technique for exploring the mechanisms of chromosome breakage and repair.
mesh_terms: D002699:Chlorambucil / Q000494:pharmacology; D002842:Chromatids / Q000502:physiology*; D002869:Chromosome Aberrations; D002875:Chromosomes / Q000528:radiation effects; D005720:Gamma Rays; D006801:Humans; D007621:Karyotyping; D011797:Quinacrine Mustard / Q000494:pharmacology; D011831:Radiation Genetics; D011995:Recombination, Genetic
chemical_list: D002699:Chlorambucil; D011797:Quinacrine Mustard