Experimental diphtheritic neuropathy in the mouse: a study in cellular resistance.
Diphtheria toxin administered by direct intraneural injection procedures demyelination in the mouse sciatic nerve. A dose in the order of 2 million times greater on an equal weight of nerve basis to required to produce the lesion compared with the dose required in the chicken.
D000818:Animals; D002645:Chickens; D003711:Demyelinating Diseases / Q000209:etiology* / Q000473:pathology; D004167:Diphtheria Toxin / Q000633:toxicity*; D051379:Mice / Q000502:physiology*; D013045:Species Specificity; D013997:Time Factors
D004167:Diphtheria Toxin