Comparison of the discriminative stimulus properties of delta9-THC and psilocybin in rats.
Male albino rats were trained to respond differentially on the left or right lever in a 2-lever chamber on the basis of which drug had been given intra-peritoneally (IP) 30 min before experimentation. In 1 group 1.9 mg/kg of delta9-THC and control injections (vehicle) served as the discriminative stimuli associated with each lever and in another group the drug stimuli were 1.0 mg/kg of delta9-THC and 1.0 mg/kg of psilocybin. The results confirmed those of other experiments using different procedures; that delta9-THC can acquire discriminative control over responding. The fact that delta9-THC and psilocybin were also found to differentially control lever choice demonstrates that these 2 drugs probably produce discriminably different states in rats.
D000818:Animals; D002188:Cannabis / Q000494:pharmacology*; D004192:Discrimination, Psychological / Q000187:drug effects*; D013759:Dronabinol / Q000494:pharmacology*; D005108:Extinction, Psychological / Q000187:drug effects; D011562:Psilocybin / Q000494:pharmacology*; D011678:Punishment; D051381:Rats; D013997:Time Factors
D011562:Psilocybin; D013759:Dronabinol