Effect of triiodothyronine treatment, thyroparathyroidectomy and mercaptoiminazole treatment on enchondral bone growth. Changes in the histological structure of the growth organ.
Histological changes caused by triiodothyronine (T3) and mercaptoiminazole treatment as well as by thyroidectomy have been studied in the proximal growth organ of the tibia of growing rats. On triiodothyronine treatment morphometric examinations revealed an increased proliferation and resorption of cartilage associated with a transitory acceleration of linear bone growth. Administration of mercaptoiminazole and thyroidectomy inhibited cartilage proliferation and resorption resulting in a slowing down of bone growth.
D000818:Animals; D001846:Bone Development; D002356:Cartilage / Q000166:cytology / Q000254:growth & development*; D008297:Male; D008713:Methimazole / Q000494:pharmacology*; D010280:Parathyroid Glands / Q000601:surgery*; D051381:Rats; D013961:Thyroid Gland / Q000502:physiology; D013965:Thyroidectomy; D013977:Tibia / Q000254:growth & development; D014284:Triiodothyronine / Q000494:pharmacology*
D014284:Triiodothyronine; D008713:Methimazole