[Effect of 3,4,5-trimethoxy-benzoyl-aminocaproic acid on the cytolytic process in myocardial infarct. Working hypothesis].
The equilibrium of the ion pump is seriously disturbed at the cell level in acute myocardial infarct. The damaged cells are unable to take up potassium and this remains in the intercellular spaces, bound to acid substances released by the necrotic site. This results in self-perpetuating damage to surrounding tissue, together with extension and aggravation of the infarct. Early treatment with 3,4,5-trimethoxy-benzoyl-aminocaproic acid enables this secondary type of lesion to be prevented, since this substance is capable of fixing potassium ions and returning them to the cell.
D000614:Aminocaproates / Q000494:pharmacology / Q000627:therapeutic use*; D006801:Humans; D009203:Myocardial Infarction / Q000188:drug therapy* / Q000378:metabolism; D009206:Myocardium / Q000378:metabolism; D011188:Potassium / Q000378:metabolism
D000614:Aminocaproates; D011188:Potassium
Influenza dell'acido 3,4,5-trimetossi-benzoil-aminocaproico sul processo citolitico in corso di infarto del miocardio. Ipotesi di lavoro