Ability of PABA to protect mammalian skin from ultraviolet light-induced skin tumors and actinic damage.
Application of 50 para-aminobenzoic acid (PABA) to hairless mice one hour prior to ultraviolet light (UVL) irradiation will almost totally protect these animals from developing tumors induced by chronic exposure to UVL in the 290 to 320 nm range in conjunction with a chemical carcinogen. Mice exposed to UVL and not protected by PABA developed primarily squamous cell carcinomas. Two months after cessation of chronic UVL exposure, the non-PABA-treated irradiated mouse skin appeared thickened, yellow, and wrinkled while showing elevated DNA synthesis, hyperplasia, hypergranulosis, and increased amounts of elastotic material. The PABA-treated skin was grossly normal.
D062365:Aminobenzoates / Q000627:therapeutic use*; D000818:Animals; D001551:Benz(a)Anthracenes; D004247:DNA / Q000096:biosynthesis; D051379:Mice; D008819:Mice, Nude; D009374:Neoplasms, Experimental / Q000139:chemically induced; D009381:Neoplasms, Radiation-Induced / Q000517:prevention & control*; D012867:Skin / Q000378:metabolism; D012878:Skin Neoplasms / Q000517:prevention & control*; D013471:Sunburn / Q000517:prevention & control*; D013473:Sunscreening Agents; D014466:Ultraviolet Rays
D062365:Aminobenzoates; D001551:Benz(a)Anthracenes; D013473:Sunscreening Agents; D004247:DNA