title: An in vitro method for evaluating tissue acceptance of foreign materials.
abstract: A method for the evaluation of the quality of acceptance of foreign materials in biologic tissue is presented: an in vitro tissue culture technique. Explants form chicken embryo hearts are placed directly on the surface of various materials and the growth of the cultures is measured following 4 days of incubation. Growth zones are recorded and these areas interpreted as an index of the acceptance of the material by the host tissue. The surface expansion apparently reflects an affinity or mechanical connection between the materials and the tissue. This concept may be of clinical importance especially in vascular reconstructive surgery. Polyester is proved to be the most suitable material in these investigations.
mesh_terms: D000818:Animals; D002482:Cellulose; D002642:Chick Embryo; D046508:Culture Techniques; D005069:Evaluation Studies as Topic; D005547:Foreign Bodies; D006321:Heart; D009757:Nylons; D010969:Plastics; D011095:Polyethylenes; D011138:Polytetrafluoroethylene; D012107:Research Design; D013232:Steel; D013997:Time Factors
chemical_list: D009757:Nylons; D010969:Plastics; D011095:Polyethylenes; D013232:Steel; D011138:Polytetrafluoroethylene; D002482:Cellulose