title: [Transfer of reduced equivalents in the cell: lactate excess].
abstract: The classical biochemical diagram that explains the part played by lactate in hypoxia is shortly recalled. The systems that insure the transfer of reducing equivalents of the cytoplasma towards the mitochondria (and conversely) are then described with full details. The excess lactate concept (XL) advanced by Huckabee (1958) in order to differentiate an hyperlactatemia with hypoxic genesis from an another one is object of discussion. This concept is false from the theoretical point of view and has no longer to be used nowadays.
mesh_terms: D001692:Biological Transport; D003593:Cytoplasm / Q000378:metabolism; D005943:Gluconeogenesis; D006801:Humans; D000860:Hypoxia / Q000378:metabolism*; D007773:Lactates / Q000378:metabolism*; D008928:Mitochondria / Q000378:metabolism; D010101:Oxygen Consumption
chemical_list: D007773:Lactates
vernacular_title: Transfert des équivalents réduits dans la cellule: l'excès de lactate