title: The influences of propranolol on serum gastrin concentration and hydrochloric acid secretion in response to hypoglycemia in normal subjects.
abstract: In ten normal subjects the effect of propranolol on serum gastrin concentration and HC1 secretion during insulin hypoglycemia (0.2 U/kg) was studied. Under the influence of propranolol (50 mug/kg intravenously in 3 min) the gastrin response to insulin was abolished. The insulin-induced HC1 secretion was reduced by propranolol from 38 to 18 mEq/2h (p less than 0.01). These results are compatible with the hypothesis of beta-adrenergic stimulation on serum gastrin concentration and HC1 secretion during insulin hypoglycemia.
mesh_terms: D000293:Adolescent; D000328:Adult; D001786:Blood Glucose; D001794:Blood Pressure / Q000187:drug effects; D005260:Female; D005750:Gastric Juice / Q000378:metabolism*; D005755:Gastrins / Q000097:blood*; D006801:Humans; D007328:Insulin / Q000494:pharmacology; D008297:Male; D011433:Propranolol / Q000494:pharmacology*; D011674:Pulse / Q000187:drug effects; D012636:Secretory Rate / Q000187:drug effects
chemical_list: D001786:Blood Glucose; D005755:Gastrins; D007328:Insulin; D011433:Propranolol