title: Different types of DNA synthesis and their importance in cancer growth and therapy.
abstract: Three main types of DNA replication has been recognized: spontaneous, stimulated and induced synthesis. The spontaneous synthesis requires, in addition to the building blocks assembled by a series of enzymes, a preexisting DNA chain which plays both as template and primer. Such pattern, operatively completed during S phase of the cycle, is strictly dependent on the structural integrity of DNA molecule and on the energy level which provokes the signal of initiation.
mesh_terms: D004254:DNA Nucleotidyltransferases / Q000378:metabolism; D004260:DNA Repair; D004261:DNA Replication; D004273:DNA, Neoplasm; D004279:DNA, Viral; D004720:Endonucleases / Q000378:metabolism; D005838:Genotype; D008938:Mitosis; D009369:Neoplasms / Q000378:metabolism* / Q000628:therapy; D009690:Nucleic Acid Conformation / Q000187:drug effects / Q000528:radiation effects; D010441:Peptide Chain Elongation, Translational; D011061:Poly A / Q000378:metabolism; D011066:Poly C / Q000378:metabolism; D011068:Poly G / Q000378:metabolism; D012313:RNA / Q000378:metabolism; D012333:RNA, Messenger; D011830:Radiation Effects; D014158:Transcription, Genetic; D014779:Virus Replication
chemical_list: D004273:DNA, Neoplasm; D004279:DNA, Viral; D012333:RNA, Messenger; D011061:Poly A; D011068:Poly G; D011066:Poly C; D012313:RNA; D004254:DNA Nucleotidyltransferases; D004720:Endonucleases