Effects of lysergic acid diethylamide (LSD) on temporal recovery (pre-pulse inhibition) of the acoustic startle response in the rat.
In a series of 6 experiments 40 mug/kg d-lysergic acid diethylamide (LSD) augmented acoustic startle amplitude in rats when long intertone intervals (4, 8, 16, or 32 sec) were used but not when short interstimulus intervals were used (0.02, 0.1, 0.5, 1, or 2 sec). In contrast, 8 mg/kg d-amphetamine augmented startle when either long or short interstimulus intervals were used. The results suggest that LSD augments startle by accelerating the decay of pre-pulse inhibition (temporal recovery process) which may be one mechanism by which LSD can alter sensory processing.
D000161:Acoustic Stimulation; D000818:Animals; D003913:Dextroamphetamine / Q000494:pharmacology; D007266:Inhibition, Psychological; D008238:Lysergic Acid Diethylamide / Q000494:pharmacology*; D008297:Male; D051381:Rats; D013216:Reflex, Startle / Q000187:drug effects*; D013997:Time Factors
D008238:Lysergic Acid Diethylamide; D003913:Dextroamphetamine