Antibodies to DNA in patients with rheumatoid arthritis and juvenile rheumatoid arthritis.
Antibodies to double-stranded DNA (DSDNA) were found in 18 patients with RA, in 5 patients with JRA, and in 5 patients with undiagnosed connective tissue disease. Five patients had clinical features consistent with both RA and SLE, 11 with only RA, and 5 with only JRA. Based on these observations, the presence of serum anti-DSDNA antibodies should not be used as a sole criterion in the diagnosis of SLE.
D000906:Antibodies; D001171:Arthritis, Juvenile / Q000276:immunology*; D001172:Arthritis, Rheumatoid / Q000276:immunology*; D004247:DNA / Q000276:immunology*; D005921:Glomerulonephritis / Q000209:etiology; D006801:Humans; D007075:Immunoglobulin M; D008171:Lung Diseases / Q000209:etiology; D008180:Lupus Erythematosus, Systemic / Q000150:complications / Q000175:diagnosis / Q000276:immunology; D009205:Myocarditis / Q000209:etiology; D009698:Nucleoproteins / Q000276:immunology; D013950:Thymus Gland / Q000276:immunology
D000906:Antibodies; D007075:Immunoglobulin M; D009698:Nucleoproteins; D004247:DNA