Pattern of anomalies following single oral doses of ethylenethiourea to pregnant rats.
Single oral administration to rats of 240 mg/kg ethylenethiourea on days 10-21 of gestation produced visceral anomalies involving the nervous, urogenital, and ocular systems, and osseous anomalies affecting the axial and appendicular skeletons. The types of anomalies and organs affected were dependent on the stage of prenatal development at the time of treatment.
D000014:Abnormalities, Drug-Induced; D000015:Abnormalities, Multiple / Q000139:chemically induced; D000284:Administration, Oral; D000818:Animals; D001842:Bone and Bones / Q000002:abnormalities; D005260:Female; D005865:Gestational Age; D009421:Nervous System Malformations; D011247:Pregnancy; D051381:Rats; D013723:Teratogens; D013890:Thiourea / Q000008:administration & dosage / Q000031:analogs & derivatives*; D014564:Urogenital Abnormalities; D014793:Visual Cortex / Q000002:abnormalities
D013723:Teratogens; D013890:Thiourea