title: Quantitative histological evaluation of early fracture healing of cortical bones immobilized by stainless steel and composite plates.
abstract: Internal fixation devices of less bending stiffness than conventional plates made of stainless steel or vitallium were compared with conventional plates in a study of fracture healing. The material for this investigation was a fine graphite fiber reinforced methyl methacrylate resin composite with a modulus of elasticity approximately ten times less than that of stainless steel. Osteotomies were performed on canine radii. Internal fixation was accomplished by means of a composite plate on the left side, and a stainless steel plate on the right. Clinical assessment, as well as biomechanical and quantitative histological techniques, were used to compare osteotomy healing of the two sides. At four months, all osteotomies had healed and the bioengineering tests showed radii from the two sides had equivalent strength. However, significantly less cortical porosity was found in the side with the composite plate (6.8 per cent), as compared to that of the stainless steel plated side (14 per cent). These results suggest that a less stiff fixation plate may have some advantage in the treatment of long bone fracture if there is no implant failure, and if union rates are equivalent.
mesh_terms: D000818:Animals; D001860:Bone Plates; D004285:Dogs; D004548:Elasticity; D005593:Fracture Fixation, Internal; D006108:Graphite; D008768:Methylmethacrylates; D010024:Osteoporosis; D011885:Radius Fractures / Q000473:pathology* / Q000601:surgery; D013314:Stress, Mechanical; D014102:Torsion Abnormality; D014945:Wound Healing
chemical_list: D008768:Methylmethacrylates; D006108:Graphite