Influence of cystamine on activity and biotransformation of hexobarbital.
Influence of cystamine on hypnotic potency and biotransformation of hexobarbital in rats was studied. Duration of hexobarbital-induced sleep was prolonged maximally by 42% on the first day after premedication, and by 37% on the third day. After six days, differences from the control group were within the limits of experimental error. Biotransformation of hexobarbital was only slightly inhibited in rats premedicated with cystamine, confirmed by determinations of hexobarbital oxidase activity. Excretion of hexobarbital and its metabolites was delayed.
D000818:Animals; D001711:Biotransformation / Q000187:drug effects; D003538:Cystamine / Q000494:pharmacology*; D006591:Hexobarbital / Q000378:metabolism*; D010088:Oxidoreductases / Q000378:metabolism; D051381:Rats; D013997:Time Factors
D006591:Hexobarbital; D010088:Oxidoreductases; D003538:Cystamine