Pathogenesis of the anemia in african trypanosomiasis: characterization and purification of a hemolytic factor.
Acute anemia is a major feature of african trypanosomiasis. It has been shown to be of hemolytic nature. Hemolytic substances were found in serum from infected animals as well as in supernatant of trypanosome suspensions. A hemolytic pronase-sensitive factor of about 10000 M.W. has been purified from such supernatants.
D000740:Anemia / Q000209:etiology*; D000818:Animals; D002470:Cell Survival; D004905:Erythrocyte Aging; D006461:Hemolysis; D051379:Mice; D014346:Trypanosoma brucei brucei / Q000378:metabolism; D014353:Trypanosomiasis, African / Q000150:complications*