Immunoglobulin secretion by mouse myeloma cells; involvement of an energy-requiring step.
The process of Immunoglobulin secretion has been extensively studied but the cellular mechanisms underlying assembly and transport of these molecules are still poorly understood. Evicence is presented in this paper for the presence, in the secretory pathway of mouse myeloma cells, of an energy requiring step, as indicated by the strong inhibition of Immunoglobulin secretion by a variety of respiratory chain inhibitors and of oxidative phosphorylation uncouplers.
D000968:Antimycin A / Q000494:pharmacology; D001692:Biological Transport; D002460:Cell Line; D002462:Cell Membrane / Q000187:drug effects / Q000378:metabolism; D004734:Energy Metabolism; D005459:Fluorides / Q000494:pharmacology; D005463:Fluoroacetates / Q000494:pharmacology; D005947:Glucose / Q000494:pharmacology; D006019:Glycolysis / Q000187:drug effects; D007136:Immunoglobulins / Q000378:metabolism*; D007460:Iodoacetamide / Q000494:pharmacology; D007700:Kinetics; D009194:Myeloma Proteins / Q000378:metabolism*; D009840:Oligomycins / Q000494:pharmacology; D013696:Temperature
D005463:Fluoroacetates; D007136:Immunoglobulins; D009194:Myeloma Proteins; D009840:Oligomycins; D000968:Antimycin A; D005947:Glucose; D005459:Fluorides; D007460:Iodoacetamide