Sesquiterpene lactones XVII. Cytostatic and pharmacological activity.
Of four lactones studied in the systems Sa-180, EAC and L-1210, two compounds: alatolide, (ALA) and eupatoriopicrin (EUPP), according to the criteria of CCNSC, showed high cytostatic activity, and ursiniolide A (URSA) "moderate" cytostatic activity against at least one type of transplantable tumor. Two compounds were selected for further confirmatory investigation: EUPP, which gave 92% inhibition of EAC and 60% increase in survival of animals bearing Leukemia L-1210; and ALA, which gave 96% inhibition of growth of EAC.
D000818:Animals; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D002286:Carcinoma, Ehrlich Tumor / Q000188:drug therapy; D003609:Dactinomycin / Q000627:therapeutic use; D007939:Leukemia L1210 / Q000188:drug therapy; D008727:Methotrexate / Q000627:therapeutic use; D051379:Mice; D008805:Mice, Inbred A; D008807:Mice, Inbred BALB C; D009368:Neoplasm Transplantation; D009374:Neoplasms, Experimental / Q000188:drug therapy*; D012510:Sarcoma 180 / Q000188:drug therapy; D012717:Sesquiterpenes / Q000627:therapeutic use*; D014184:Transplantation, Homologous
D000970:Antineoplastic Agents; D012717:Sesquiterpenes; D003609:Dactinomycin; D008727:Methotrexate