L-tetramisole. Enhancement of human lymphocyte response to antigen.
The anthelminthic drug L-Tetramisole enhanced in vitro lymphocyte transformation of normal young adults in the presence of PPD, Candida or measles antigen. This enhancement occurred regardless of evident pre-existing immunity to the antigen used. The increase in stimulation obtained by the drug and antigen combined, beyond that by antigen alone, varied between 1-25 and 5-99 for all three antigens in fourteen cell donors. Lymphocyte transformation was induced in seven individuals by the drug alone and suppressed in two. In levamisole dose--response tests, the optimum dose for this in vitro effect in six donors was similar for the three antigens.
D000328:Adult; D000941:Antigens; D000946:Antigens, Fungal; D000956:Antigens, Viral; D002175:Candida / Q000276:immunology; D004305:Dose-Response Relationship, Drug; D006801:Humans; D007978:Levamisole / Q000494:pharmacology; D008213:Lymphocyte Activation / Q000187:drug effects*; D008459:Measles virus / Q000276:immunology; D013773:Tetramisole / Q000494:pharmacology*; D014373:Tuberculin
D000941:Antigens; D000946:Antigens, Fungal; D000956:Antigens, Viral; D014373:Tuberculin; D007978:Levamisole; D013773:Tetramisole