[Acute prostaglandin E changes in the kidney medulla after intravenous application of blood pressure active drugs in rabbits].
The blood pressure active substances noradrenaline, alpha-methyl-dopa, clonidine, dihydralazine, and reserpine were studied 20 min after i.v. administration to rabbits for their action on blood pressure, heart rate, PGE-content and -synthesis in the renal medulla. Noradrenaline caused increase in blood pressure, and distinctly enhanced the PGE content in the renal medulla. alpha-methyl-dopa raised both PGE-content and -synthesis, without changing blood pressure and heart rate. Clonidine and dihydralazine caused a pronounced fall of the blood pressure, but only did dihydralazine lower PGE-synthesis, while no such effect was produced by clonidine. Reserpine, like dihydralazine, decreased PGE-synthesis, without simultaneously lowering blood pressure. Indomethacine, one of the most potent inhibitors of PG-synthesis, has no effect on blood pressure within 20 min. The results argue against the existence of a simple direct correlation between PGE-synthesis rate in the homogenate of rabbit renal medulla and the instantaneous blood pressure.
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects*; D003000:Clonidine / Q000494:pharmacology; D004078:Dihydralazine / Q000494:pharmacology; D005260:Female; D006339:Heart Rate / Q000187:drug effects; D007213:Indomethacin / Q000494:pharmacology; D007668:Kidney / Q000187:drug effects*; D007679:Kidney Medulla / Q000187:drug effects* / Q000378:metabolism; D008297:Male; D008750:Methyldopa / Q000494:pharmacology; D009638:Norepinephrine / Q000494:pharmacology; D011458:Prostaglandins E / Q000096:biosynthesis*; D011817:Rabbits; D012110:Reserpine / Q000494:pharmacology
D011458:Prostaglandins E; D008750:Methyldopa; D012110:Reserpine; D003000:Clonidine; D004078:Dihydralazine; D009638:Norepinephrine; D007213:Indomethacin
Akute Prostaglandin E-Veränderungen in Nierenmark nach intravenöser Gabe blutdruckwirksamer Pharmaka an Kaninchen