[Measurement of the oxygen affinity of hemoglobin. Application to patients with angina pectoris with normal coronography. Study of 10 cases].
A study of 2-3 D.P.C. (diphosphoglycerate) and of P50 (PO2 of half-saturation of blood at pH 7.40, PCO2 40 torr and temperature 37 degrees C) was carried out in ten subjects: eight women and two men suffering from angina pectoris with no evidence of obstruction on their coronary arteriograms. The study was made with the subjects at rest, in the absence of any acute coronary episode. The results show that these patients have a normal affinity of haemoglobin for oxygen: the 2-3 D.P.G. was 13.05 +/- 2.2 muM.g-1 Hb; P50 was 26.7 +/- 1.3 torr; Hill's "n" was 2.65 +/- 0.29. Deviation to the right of the oxyhaemoglobin curve may be seen, after effort or during a provoked attack, but this movement to the right seems to be the result rather than the cause of the myocardial ischaemia.
D000328:Adult; D000787:Angina Pectoris / Q000097:blood*; D002245:Carbon Dioxide / Q000097:blood; D004163:Diphosphoglyceric Acids / Q000097:blood; D005260:Female; D006454:Hemoglobins; D006801:Humans; D008297:Male; D008875:Middle Aged; D010100:Oxygen / Q000097:blood*; D010108:Oxyhemoglobins / Q000032:analysis; D010313:Partial Pressure
D004163:Diphosphoglyceric Acids; D006454:Hemoglobins; D010108:Oxyhemoglobins; D002245:Carbon Dioxide; D010100:Oxygen
Mesure de l'affinité de l'hémoglobine pour l'oxygène. Application aux malades atteints d'angine de poitrine avec coronarographie normale. Etude de dix cas