Influence of adrenal dysfunction on activity and pharmacokinetics of some neutropic drugs. II. Influence of chronic premedication with dexamethasone on pharmacodynamic activity and pharmacokinetics of drugs.
The influence of long-term administration of dexamethasone on pharmacodynamic activity and biotransformation of salicylamide and hexobarbital, including their absorption, distribution and excretion, were studied. Activities of the following enzymes were also determined: beta-glucuronidase (E.C.3.2.1.31), uridinediphosphoglucose dehydrogenase (E.C.1.1.1.22), uridinediphosphoglucuronyl transferase (E.C.2.4.1.17), uridinediphosphoglucuronic pyrophosphatase (E.C.3.6.1.9), and hexobarbital oxidase.
D000307:Adrenal Gland Diseases / Q000139:chemically induced; D000311:Adrenal Glands / Q000502:physiology*; D000818:Animals; D001711:Biotransformation; D006591:Hexobarbital / Q000378:metabolism / Q000494:pharmacology; D007700:Kinetics; D051379:Mice; D004364:Pharmaceutical Preparations / Q000378:metabolism*; D051381:Rats; D012457:Salicylamides / Q000378:metabolism / Q000494:pharmacology; D012890:Sleep / Q000187:drug effects; D013997:Time Factors
D004364:Pharmaceutical Preparations; D012457:Salicylamides; D006591:Hexobarbital