Effect of the antitumor antibiotic chromomycin A3 on the humoral immune response in rats.
Chromomycin A3 (250 mug/kg) suppressed the humoral immune response in rats against sheep erythrocytes when administered 48 h or later after antigenic stimulus. The antibiotic at this dose enhanced immunity when given along with or before antigen administration. The natural heterohemagglutinin levels in rabbits and guinea pigs were not affected by the antibiotic (10 mug/kg per day x 7).
D000818:Animals; D000917:Antibody Formation / Q000187:drug effects*; D000941:Antigens / Q000008:administration & dosage; D000970:Antineoplastic Agents / Q000494:pharmacology; D002865:Chromomycins / Q000008:administration & dosage / Q000494:pharmacology*; D004912:Erythrocytes / Q000276:immunology; D005260:Female; D006168:Guinea Pigs; D006388:Hemagglutinins / Q000032:analysis; D006460:Hemolysin Proteins / Q000032:analysis; D007109:Immunity / Q000187:drug effects; D007274:Injections, Intraperitoneal; D008297:Male; D011817:Rabbits; D051381:Rats; D011919:Rats, Inbred Strains; D012756:Sheep; D013997:Time Factors
D000941:Antigens; D000970:Antineoplastic Agents; D002865:Chromomycins; D006388:Hemagglutinins; D006460:Hemolysin Proteins