[The phenomenon of experimental motor retardation as one of the manifestations of the Parkinsonian syndrome].
A low frequency stimulation of the head of the caudate nucleus in freely moving cats leads to an arrest of reactions with an increased muscular tone and tremor. This reaction may serve as an experimental model of one of the expressions of parkinsonism, inasmuch as its accomplishment depends upon the central dopaminergic mechanisms (confirmed on experiments with disulfiram and alpha-methyltyrosine). The similarity is also supplemented by the fact that the arrested reaction is weakened by antiparkinson drugs (d, 1-amphetamine, DOPA, artane) and is increased by neuroeptical preparation (aminazine, haloperidol, reserpine).
D000661:Amphetamine / Q000627:therapeutic use; D000818:Animals; D002395:Catecholamines / Q000502:physiology; D002415:Cats; D002421:Caudate Nucleus / Q000502:physiology; D002746:Chlorpromazine / Q000627:therapeutic use; D004088:Dihydroergotoxine / Q000627:therapeutic use; D004195:Disease Models, Animal; D004221:Disulfiram / Q000627:therapeutic use; D004558:Electric Stimulation; D008781:Methyltyrosines / Q000627:therapeutic use; D009043:Motor Activity / Q000502:physiology; D009132:Muscles / Q000502:physiology; D010300:Parkinson Disease / Q000188:drug therapy; D011433:Propranolol / Q000627:therapeutic use
D002395:Catecholamines; D008781:Methyltyrosines; D004088:Dihydroergotoxine; D011433:Propranolol; D000661:Amphetamine; D004221:Disulfiram; D002746:Chlorpromazine
Fenomen éksperimental'noĭ zaderzhki dvizheniĭ kak odno iz proiavleniĭ parkinsonicheskogo sindroma