Restoration of nucleic acid biosynthesis after clinical death and factors stimulating the process in vivo.
The biosynthesis of RNA and DNA falls almost to zero in 60 min after the death of rabbits from anoxia, in all the organs of the body. Rapid artificial cooling of the rabbits to 20 degrees C undertaken within 10 min after death preserved nucleic acid biosynthesis and permitted restoration of life 3-4 h after death, with recovery beginning in 60 min. During the reanimation the addition of ATP to the blood stimulated the restoration of RNA biosynthesis in the spinal cord to a considerable extent; the addition of cocarboxylase to the blood promoted cardiac RNA biosynthesis as well as cardiac and pancreatic DNA biosynthesis during recovery.
D000255:Adenosine Triphosphate / Q000097:blood; D000818:Animals; D003080:Cold Temperature; D004247:DNA / Q000096:biosynthesis*; D003643:Death; D009206:Myocardium / Q000378:metabolism; D010179:Pancreas / Q000378:metabolism; D012313:RNA / Q000096:biosynthesis*; D011817:Rabbits; D012151:Resuscitation; D013116:Spinal Cord / Q000378:metabolism; D013268:Stimulation, Chemical; D013997:Time Factors
D012313:RNA; D000255:Adenosine Triphosphate; D004247:DNA