The lymphoid bone marrow. An experimental model.
An experimental model is proposed whereby rat bone marrow is converted to a lymphoid-like tissue. A single i.p. injection of hydroxyurea (250 mg/kg body weight) destroys replicating marrow cells in DNA synthesis. Bone marrow erythroblasts constitute the vast majority of cells in cycle under the steady-state of hematopoiesis. Six hours following a single injection of hydroxyurea, selective damage of erythroblasts is noted. The depleted erythroid compartment appears to be replenished by cells of a lymphoid configuration. At 24 hr after injection the erythroid compartment is restored to normal activity. It is suggested that 6 hr after administration of hydroxyurea, lymphoid cells of rat bone marrow may be a source of stem cells for the depleted erythroid compartment.
D000818:Animals; D001853:Bone Marrow / Q000187:drug effects*; D001854:Bone Marrow Cells; D004261:DNA Replication / Q000187:drug effects; D004900:Erythroblasts / Q000187:drug effects*; D004912:Erythrocytes / Q000187:drug effects*; D006412:Hematopoietic Stem Cells / Q000187:drug effects; D006918:Hydroxyurea / Q000494:pharmacology; D008221:Lymphoid Tissue / Q000166:cytology; D008954:Models, Biological; D051381:Rats
D006918:Hydroxyurea