Inhibitory substance (substance I) in rat liver of dopamine-beta-hydroxylase and its effect on the rat blood pressure.
In a series of experiments undertaken to investigate the naturally occurring inhibitors of dopamine-beta-hydroxylase, we extracted some active substance from rat liver. This substance was named "substance I" because of its inhibitory effect on the dopamine-beta-hydroxylase. Substance I had some hypotensive effect on the rat blood pressure.
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects*; D004299:Dopamine beta-Hydroxylase / Q000037:antagonists & inhibitors*; D008099:Liver / Q000032:analysis*; D051381:Rats; D014020:Tissue Extracts / Q000494:pharmacology*
D014020:Tissue Extracts; D004299:Dopamine beta-Hydroxylase