[Stimulation of renal excretion of p-aminohippuric acid by repeated administration of drugs in young and adult rats].
The velocity of renal excretion of p-aminohippuric acid (PAH) could be raised by repeated administration of phenol red, probenecid and penicillin, which are actively transported by the acid carrier into the urine like PAH. These drugs produced an effect in fairly lower doses than PAH. The renal excretion of PAH can be accelerated by repeated pretreatment with the lipid-soluble drugs sulfaclomide, sulfamethoxypyridazine and cyclopenthiazide. It could be demonstrated that the stimulation of renal excretion of PAH by repeated administration of the investigated compounds is less pronounced in young rats than in adult animals.
D000618:Aminohippuric Acids / Q000652:urine*; D000818:Animals; D003518:Cyclopenthiazide / Q000494:pharmacology; D007668:Kidney / Q000187:drug effects* / Q000378:metabolism; D010406:Penicillins / Q000494:pharmacology; D010637:Phenolsulfonphthalein / Q000494:pharmacology; D011339:Probenecid / Q000494:pharmacology; D051381:Rats; D013268:Stimulation, Chemical; D013421:Sulfamethoxypyridazine / Q000494:pharmacology; D013997:Time Factors
D000618:Aminohippuric Acids; D010406:Penicillins; D010637:Phenolsulfonphthalein; D011339:Probenecid; D013421:Sulfamethoxypyridazine; D003518:Cyclopenthiazide
Stimulierung der renalen Ausscheidung von-Aminohippursäure durch wiederholte Zufuhr von Pharmaka bei jungen und erwachsenen Ratten