Familial presacral teratomas.
A tumor complex consisting of presacral teratoma and sacral deformity was described along with its occurrence in 6 kindreds. In addition to the tumor and the sacral defect, some patients have had recurrent abscesses, rectal stenosis and skin dimples as manifestation of the tumor. Urinary tract anomalies have also been found to be associated in some patients. The tumor differed considerably from the usual sacrococcygeal teratoma. Only one of the 19 resected tumors had proved to be malignant, although 2 have recurred in a benign manner. This appears to be inherited as a dominant characteristic.
D000293:Adolescent; D000328:Adult; D000368:Aged; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D008875:Middle Aged; D010375:Pedigree; D010386:Pelvic Neoplasms / Q000235:genetics*; D012445:Sacrococcygeal Region; D012447:Sacrum / Q000002:abnormalities*; D013724:Teratoma / Q000235:genetics*