A study of chromosomes of lymphocytes from patients treated with hycanthone.
The frequency of cells presenting chromosome abnormalities was determined in patients with schistosomiasis before and after treatment with a single dose of 2.5 mg/kg body weight of hycanthone methanosulfonate. No significant effect of the drug was detected with this therapeutic dose.
D002478:Cells, Cultured; D002842:Chromatids / Q000187:drug effects; D002869:Chromosome Aberrations; D002875:Chromosomes / Q000187:drug effects*; D006801:Humans; D006826:Hycanthone / Q000009:adverse effects / Q000494:pharmacology* / Q000627:therapeutic use; D008214:Lymphocytes / Q000648:ultrastructure*; D009153:Mutagens; D012552:Schistosomiasis / Q000188:drug therapy; D013892:Thioxanthenes / Q000494:pharmacology*
D009153:Mutagens; D013892:Thioxanthenes; D006826:Hycanthone