[Metabolizability of RNA in the liver mitochondia of rats under the influence of hydrocortisone and sodium ribonucleinate].
Sodium ribonucleate and hydrocortizone-acetate (5 mg/100 g) separately and in combination were injected to the intact albino rats daily for 14 days. The multiple injections of hydrocortizone cause in the liver mitochondria a change in the ratio of RNA (17 S and 13 S) and tRNA (4 S), as well as a decrease in the intensity of the radioactive predecessors (orthophosphate-P32 orotate-C14 and uridine-H3) incorporation into tRNA and tRNA of the liver mitochondria, decay inhibition of mitochondrial tRNA and to a less extent - of rRNA. The multiple injections of ribonucleate evoke intensification of the labelled predecessors incorporation into tRNA and rRNA of the liver mitochondria. With injections of ribonucleinate in combination with hydrocortizone the negative effect of hydrocortizone surplus on incorporation of the labelled predecessors into mitochondrial RNA and on the ratio of rRNA and tRNA in the mitochondria is related by a positive effect of ribonucleinate.
D000818:Animals; D006854:Hydrocortisone / Q000494:pharmacology*; D008297:Male; D008930:Mitochondria, Liver / Q000378:metabolism*; D012313:RNA / Q000378:metabolism* / Q000494:pharmacology*; D012335:RNA, Ribosomal / Q000378:metabolism; D012343:RNA, Transfer / Q000378:metabolism; D051381:Rats
D012335:RNA, Ribosomal; D012313:RNA; D012343:RNA, Transfer; D006854:Hydrocortisone
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