[Influence of chronic injections of aminazin on the oogenesis and development of the progeny of animals (white mice)].
When introduced repeatedly prior to the onset of pregnancy chlorpromazine in a dose of 16 mg/kg limits the progeny of albino mice. An important factor responsible for the reduction in the number of young mice in the litter is inhibition of oogenesis. A single injection of the same dose of chlorpromazine made at the end of gestation (18th day) against the background of its preliminary administration before the onset of pregnancy results in an interruption of the latter, or in a gravely disturbed post-natal development of some of the offsprings. The disturbances find their expression in a delayed growth and motor activity, incoordination of motions and are accompanied by changes in the tegument, diarrhea (form the moment of changing over to a mixed alimentation), in underdevelopment of the organs and of histological structures that are part of them.
D000014:Abnormalities, Drug-Induced; D000818:Animals; D002746:Chlorpromazine / Q000633:toxicity*; D004622:Embryo, Mammalian / Q000187:drug effects*; D005260:Female; D005865:Gestational Age; D051379:Mice; D009866:Oogenesis / Q000187:drug effects*; D011247:Pregnancy
D002746:Chlorpromazine
O vliianii khronicheskikh in'ektsiĭ aminazina na oogenez i razvitie potomstva zhivotnykh (belykh mysheĭ)