The effect of long-term administration of adrenaline, metanephrine and propranolol on the triphasic intestinal reaction on adrenaline in the rat.
The effect 6 weeks long treatment of rats with L-adrenaline (1 mg/kg sc), D,L-metanephrine (20 mg/kg sc) and D-propranolol (10 mg/kg po) on isolated ileum triphasic reaction on adrenaline was studied. Adrenaline and metanephrine increased the sensitivity of relaxation response and decreased the contraction phase of smooth muscle to adrenaline. In the contrary propranolol decreased relaxation and increased contraction phase of triphasic reaction. The results presented by us support our previous suggestion that the triphasic intestinal reaction on adrenaline is related to extraneuronal accumulation of catecholamines.
D000818:Animals; D004837:Epinephrine / Q000031:analogs & derivatives* / Q000494:pharmacology*; D007082:Ileum / Q000187:drug effects*; D066298:In Vitro Techniques; D008297:Male; D008676:Metanephrine / Q000494:pharmacology*; D009119:Muscle Contraction / Q000187:drug effects; D011433:Propranolol / Q000494:pharmacology*; D051381:Rats
D008676:Metanephrine; D011433:Propranolol; D004837:Epinephrine