[The effect of local non-specific sensitization with 2,4-dinitrochlorbenzene on chemical carcinogenesis].
The induction of benzpyrene skin carcinogenesis was suppressed by repeated administrations of DNCB in C57Bl mice. DNCB was found to protect the development of the immunodepression induced by benzpyrene. The most appreciable effect was observed when DNCB applications were started two months before the benzpyrene administration. An insignificant inhibition or therapeutic effect was noted during later stages of the benzpyrene carcinogenesis.
D000818:Animals; D001580:Benzopyrenes / Q000037:antagonists & inhibitors*; D004137:Dinitrochlorobenzene / Q000627:therapeutic use*; D007114:Immunization / Q000379:methods*; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D009578:Nitrobenzenes / Q000627:therapeutic use*; D010212:Papilloma / Q000139:chemically induced / Q000517:prevention & control* / Q000628:therapy; D012878:Skin Neoplasms / Q000139:chemically induced / Q000517:prevention & control* / Q000628:therapy
D001580:Benzopyrenes; D004137:Dinitrochlorobenzene; D009578:Nitrobenzenes
Vliianie mestnoĭ nespetsificheskoĭ sensibilizatsii 2,4-dinitrokhlorbenzolom na khimicheskiĭ kantserogenez