Variations in sensitivity of synchronized Chinese hamster cells to oxic and anoxic X-ray exposures.
V-79 Chinese hamster cells in monolayer cultures on glass surfaces were synchronized by treatment with hydroxyurea and exposed at different times thereafter to X-rays in the air or in oxygen-free argon. Survival determinations indicated that the oxygen enhancement ratio OER as expressed by the ratio of the respective D0 values varied over a narrow range in the different phases of the cell cycle. These changes resulted from cyclic alterations in both aerobic and anaerobic D0 values, and perhaps in n values.
D000388:Air; D001128:Argon; D002455:Cell Division; D002460:Cell Line; D002470:Cell Survival; D002478:Cells, Cultured / Q000528:radiation effects; D004307:Dose-Response Relationship, Radiation; D006918:Hydroxyurea / Q000494:pharmacology; D010100:Oxygen; D011830:Radiation Effects; D014965:X-Rays
D001128:Argon; D010100:Oxygen; D006918:Hydroxyurea