Effects on long-term cadmium exposure on the seminal vesicles of mice.
Male CBA-mice were exposed to cadmium by subcutaneous injection of 2-2 mumol CdCl2/kg body weight for 5 days/week for 6 months. A decrease in normal (testosterone-dependent) proteinuria was shown, and morphological examination of the seminal vesicles revealed a smaller weight and size as well as histological indication of lower secretory activity of the epithelium compared to controls. The findings are consistent with a theory implying a decreased testosterone activity in cadmium-treated animals.
D000818:Animals; D002104:Cadmium / Q000494:pharmacology*; D003864:Depression, Chemical; D008297:Male; D051379:Mice; D011507:Proteinuria; D012669:Seminal Vesicles / Q000033:anatomy & histology / Q000187:drug effects*; D013739:Testosterone / Q000096:biosynthesis
D002104:Cadmium; D013739:Testosterone