[The effect of insulin on the functional state of the cardiovascular system in patients with diabetes mellitus].
The influence of the hypoglycemic effect of the therapeutic doses of insulin on the functional condition of the cardiovascular system was studied under clinical conditions in 74 patients with various forms of diabetes mellitus; mechanocardiography was used for this purpose. Myocardial hyperfunction, an increase in the tone of the large arteries, disturbance of correlation between the cardiac output and the peripheral resistance accompanied diabetes mellitus. A moderate reduction of glycemia after insulin administration (not over 50 mg%) promoted an improvement of the cardiovascular system function, facilitated the cardiac and the extracardiac conditions of the myocardial function. A marked fall of the blood level, particularly by over 100 mg%, produced an unfavourable effect on the cardiovascular system, and aggravated the hemodynamic shifts. The optimal admissible variations in glycemia during the treatment of a diabetic patients with insulin of short action is +/-50 mg%. A gradual reduction or normalization of the blood sugar level in diabetes mellitus served as one of the important factors of prophylaxis and progress of cardiovascular disturbances in diabetes mellitus.
D000293:Adolescent; D000328:Adult; D001161:Arteriosclerosis / Q000150:complications; D002302:Cardiac Output; D048909:Diabetes Complications; D003920:Diabetes Mellitus / Q000188:drug therapy* / Q000503:physiopathology; D003925:Diabetic Angiopathies / Q000188:drug therapy; D005260:Female; D006439:Hemodynamics; D006801:Humans; D007328:Insulin / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D011674:Pulse; D014655:Vascular Resistance
D007328:Insulin
Vliianie insulina na funktsional'noe sostoianie serdechno-sosudistoĭ sistemy u bol'nykh sakharnym diabetom