Pathological changes in the liver of mice given 2,3,7,8-tetrachlorodibenzo-p-dioxin.
In C57BL/6 mice a single oral dose of 2,3,7,8-tetrachlorodibenzodioxin (LD50 126 mug/kg) results in loss of body weight and death with an enlarged fatty liver after ca. 21 days. A progressive necrotic centrilobular liver lesion is also seen.
D000818:Animals; D001835:Body Weight; D002784:Cholesterol / Q000378:metabolism; D003135:Common Bile Duct / Q000473:pathology; D004147:Dioxins / Q000506:poisoning*; D005227:Fatty Acids / Q000378:metabolism; D005234:Fatty Liver / Q000139:chemically induced; D008099:Liver / Q000187:drug effects / Q000378:metabolism / Q000473:pathology*; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D009929:Organ Size; D000072317:Polychlorinated Dibenzodioxins / Q000494:pharmacology / Q000506:poisoning*
D004147:Dioxins; D005227:Fatty Acids; D000072317:Polychlorinated Dibenzodioxins; D002784:Cholesterol