[Age-related peculiarities of the effect of angiotensin-2 on some hemodynamic indices].
Changes occurring in some aspects of the hemodynamics following intravenous administration of different doses of angiotensin-2 were studied in tests staged on adult and old rabbits of both sexes. The older animals are shown to be more sensitive to this drug, for in them low doses (0.01, 0.1 gamma/kg) produced a significant elevation of the arterial pressure. On introduction of such doses the older animals more often demonstrate an accretion of the cardiac output. Introduction of the same doses to adult rabbits is more frequently attended by a rise of the total peripheral resistance. Upon administration of large doses of angiotensin-2 (1, 5 gamma/kg) the adult and older rabbits present more often a rise of the total peripheral resistance.
D000367:Age Factors; D000804:Angiotensin II / Q000494:pharmacology*; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D002302:Cardiac Output / Q000187:drug effects; D005260:Female; D006439:Hemodynamics / Q000187:drug effects*; D008297:Male; D011817:Rabbits; D014655:Vascular Resistance / Q000187:drug effects
D000804:Angiotensin II
Vozrastnye osobennosti deĭstviia angiotenzina-2 na nekotorye gemodinamicheskie pokazateli