The early enhancement of rat liver deoxyribonucleic acid-dependent ribonucleic acid polymerase II activity by tri-iodothyronine.
It is shown that tri-iodothyronine injected intravenously into thyroidectomized rats induces an early and transient activation of rat liver RNA polymerase II which could be demonstrated to occur 40-80 min after hormonal treatment. There was a simultaneous increase in the concentration of acidic proteins bound to chromatin.
D000546:Amanitins / Q000494:pharmacology; D000818:Animals; D002843:Chromatin; D004247:DNA; D012321:DNA-Directed RNA Polymerases / Q000378:metabolism*; D004789:Enzyme Activation; D008099:Liver / Q000187:drug effects / Q000201:enzymology*; D011485:Protein Binding; D051381:Rats; D013965:Thyroidectomy; D014284:Triiodothyronine / Q000494:pharmacology*
D000546:Amanitins; D002843:Chromatin; D014284:Triiodothyronine; D004247:DNA; D012321:DNA-Directed RNA Polymerases