Duration of antinociceptive action of morphine, methadone and alpha-l-acetylmethadol subcutaneously in rats.
The duration of antinociceptive action of alpha-l-acetylmethadol (LAM), determined in the rat tail pinch test, was 6 times that of morphine and 3 times that of methadone. Onset of activity was considerably later after LAM than after morphine or methadone.
D000698:Analgesia; D000818:Animals; D007279:Injections, Subcutaneous; D008297:Male; D008691:Methadone / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000494:pharmacology*; D008692:Methadyl Acetate / Q000008:administration & dosage / Q000494:pharmacology*; D009020:Morphine / Q000008:administration & dosage / Q000494:pharmacology*; D051381:Rats; D011930:Reaction Time / Q000187:drug effects; D013997:Time Factors; D014828:Vocalization, Animal / Q000187:drug effects
D009020:Morphine; D008692:Methadyl Acetate; D008691:Methadone