Fluctuations of plasma phenytoin levels on single dose and twice daily dose regimes.
Eight chronic refractory epileptics were studied with regard to frequency of administration of phenytoin. There were no excessive fluctuations in plasma levels when the total drug dose was given as a single daily dose, and the clinical state of the patients was unchanged from that on twice daily dosage.
D000293:Adolescent; D000328:Adult; D002648:Child; D002908:Chronic Disease; D004334:Drug Administration Schedule; D004827:Epilepsy / Q000097:blood* / Q000188:drug therapy; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010672:Phenytoin / Q000008:administration & dosage / Q000097:blood* / Q000627:therapeutic use
D010672:Phenytoin