Hypothalamo-pituitary-adrenal function in intrinsic non-atopic asthma.
Sixteen patients with intrinsic non-atopic asthma with persistent wheezing who had never been treated with corticosteroids showed normal adrenocortical responses to prolonged stimulation with Tetracosactin Depot. In a subgroup of six patients the hypothalamo-pituitary-adrenal (HPA) response to a standard insulin stress test was normal. It is concluded that impaired responsiveness of the HPA axis is unlikely to be a common factor in initiating or maintaining airways obstruction in patients with intrinsic asthma.
D000311:Adrenal Glands / Q000187:drug effects / Q000503:physiopathology*; D001249:Asthma / Q000097:blood / Q000175:diagnosis / Q000503:physiopathology*; D003366:Cosyntropin / Q000494:pharmacology; D006801:Humans; D006854:Hydrocortisone / Q000097:blood; D007031:Hypothalamus / Q000503:physiopathology*; D007328:Insulin; D010902:Pituitary Gland / Q000503:physiopathology*
D007328:Insulin; D003366:Cosyntropin; D006854:Hydrocortisone