Normalization of fasting hyperglucagonemia and excessive glucagon responses to intravenous arginine in human diabetes mellitus by prolonged infusion of insulin.
Infusion of insulin (1 U/hr) for 14 hr suppressed basal glucagon levels and normalized previously excessive glucagon responses to arginine in juvenile-onset, insulin-dependent diabetic subjects, indicating that abnormal pancreatic alpha-cell function in human juvenile-onset diabetes mellitus may be a consequence of insulin lack.
D000328:Adult; D001120:Arginine; D003920:Diabetes Mellitus / Q000188:drug therapy*; D005215:Fasting; D005260:Female; D005934:Glucagon / Q000097:blood* / Q000378:metabolism; D006801:Humans; D007328:Insulin / Q000627:therapeutic use*; D008297:Male; D013997:Time Factors
D007328:Insulin; D005934:Glucagon; D001120:Arginine