Effect of glucocorticosteroids on phagosome-lysosome interaction.
The effects of hydrocortisone on fusion of thorotrast-labeled lysosomes with phagosomes containing killed toxoplasmas was studied. Mouse peritoneal macrophages from glucocorticosteroid-treated animals fromed phagolysosomes just as effectively as macrophages from untreated animals (72% thorotrast-positive vacuoles in hydrocortisone-treated animals; 78% in controls). The electron microscopic appearence of macrophages from treated or untreated animals was similar. This observation complements studies which show no change in intracellular microbicidal activity in macrophages treated with glucocorticosteriods.
D000818:Animals; D006854:Hydrocortisone / Q000494:pharmacology*; D008247:Lysosomes / Q000378:metabolism / Q000502:physiology*; D008264:Macrophages / Q000187:drug effects / Q000648:ultrastructure; D051379:Mice; D010586:Phagocytes / Q000502:physiology*; D010587:Phagocytosis / Q000187:drug effects*; D014122:Toxoplasma
D006854:Hydrocortisone