Temporary sterility produced in male mice by 5-thio-D-glucose.
When 5-thio-D-glucose was fed to male mice at daily dose levels greater than 30 mg/kg sperm development was completely inhibited within 3 weeks and remained so without impairment of libido for the experimental period of 7 weeks. Removal of this substance from the diet resulted in a resumption of sperm development and fertility within 5 to 8 weeks. Normal litters were sired by males which had recovered after this treatment.
D000818:Animals; D005947:Glucose / Q000031:analogs & derivatives* / Q000494:pharmacology; D007248:Infertility, Male / Q000139:chemically induced* / Q000473:pathology; D008297:Male; D051379:Mice; D012671:Seminiferous Tubules / Q000473:pathology; D013091:Spermatogenesis / Q000187:drug effects
D005947:Glucose