Pathogenesis of in utero infection: experimental infection of eight- and ten-week-old porcine fetuses with porcine parvovirus.
Selected numbers of fetuses in each of 4 pregnant gilts were exposed to a porcine parvovirus by injecting the virus into the allantoic fluid at gestation day 56 or 70. The fetuses were examined on postexposure day 7 or 14. When pregnancy was terminated, 2 of 15 exposed fetuses were dead. Several fetuses tested at post-exposure day 14 had hemagglutination-inhibiting antibodies to porcine parvovirus. Virus was detected most frequently and in highest concentration in the parenchymatous organs of thorax and abdomen of fetuses exposed on gestation day 56. A small amount of antigen was in neurons and capillary endothelium of cerebral and cerebellar cortexes.
D000818:Animals; D000956:Antigens, Viral; D005260:Female; D005315:Fetal Diseases / Q000276:immunology / Q000382:microbiology / Q000662:veterinary*; D005333:Fetus / Q000382:microbiology; D007668:Kidney / Q000276:immunology; D010321:Parvoviridae / Q000276:immunology / Q000302:isolation & purification; D011247:Pregnancy; D012272:Ribs / Q000276:immunology; D013552:Swine; D013553:Swine Diseases / Q000276:immunology / Q000382:microbiology; D014777:Virus Diseases / Q000276:immunology / Q000382:microbiology / Q000662:veterinary
D000956:Antigens, Viral