[The effect of mellerin on the lysosomal membranes of rat brain and liver].
Following one hour after the administration of melleril intramuscularly in dozes from 30 mg/kg of weight (when its concentration in the liver and brain attained the mazimal figures) there was a labilization of the membranes by liver and brain lysis in experimental animals. The membrane damage was evaluated by the increased activity of the marker enzyme -- acidic phosphotase in an suprasedimentive liquid, as well as by the activation of the enzymes in the fraction by lysis, eliminated from the tissue of the brain and liver. The achieved data may reflect the interaction of the introduced preparation with the membrane by lysis, subcellular particles which participate in freeing the organism from an excessively introduced preparation.
D000135:Acid Phosphatase / Q000378:metabolism; D000818:Animals; D001921:Brain / Q000187:drug effects* / Q000201:enzymology / Q000648:ultrastructure; D002746:Chlorpromazine / Q000494:pharmacology; D005260:Female; D008099:Liver / Q000187:drug effects* / Q000201:enzymology / Q000648:ultrastructure; D008247:Lysosomes / Q000187:drug effects*; D008297:Male; D051381:Rats; D013881:Thioridazine / Q000494:pharmacology*
D000135:Acid Phosphatase; D013881:Thioridazine; D002746:Chlorpromazine
Vliianie mellerina na membrany lizosom mozga i pecheni krys