title: [Study of the inhibition of mitotic activity in the rat liver].
abstract: When affecting the rat liver cells by the alkylating agent dipin or X-ray irradiation in combination with genome induction by phenobarbital, a considerable decrease was observed in the mitotic activity of hepatocytes after hepatoectomy. The decrease in the mitotic activity is preserved for 90 days between introduction of mutagene and phenobarbital. When increasing the time interval to 150 days the inhibition in the mitotic activity is not observed.
mesh_terms: D000477:Alkylating Agents / Q000494:pharmacology; D000818:Animals; D003864:Depression, Chemical; D005838:Genotype; D006498:Hepatectomy; D008099:Liver / Q000166:cytology* / Q000187:drug effects / Q000528:radiation effects; D008115:Liver Regeneration; D008297:Male; D008938:Mitosis / Q000187:drug effects* / Q000528:radiation effects; D009154:Mutation / Q000187:drug effects / Q000528:radiation effects; D009943:Organophosphorus Compounds / Q000494:pharmacology; D010634:Phenobarbital / Q000494:pharmacology; D010879:Piperazines / Q000494:pharmacology; D011830:Radiation Effects; D051381:Rats; D013997:Time Factors
chemical_list: D000477:Alkylating Agents; D009943:Organophosphorus Compounds; D010879:Piperazines; D010634:Phenobarbital
vernacular_title: Issledovanie tormozheniia mitoticheskoĭ aktivnosti v pecheni krysy