[The effect of 11-deoxycortiocosterone acetate on the antitumor activity of prospidin].
Male rats with sarcoma 45 being intact with respect to the adrenal gland and thyroid were subjected to bilateral adrenalectomy or thyroidectomy. The experiments have indicated that 11-desoxycorticosterone acetate (DOCA) injected intramuscularly in the dosage of 30-45 and 80-90 mg/Kg daily during 6-8 days (terms of observation-14-16 days since the moment of tumor transplantation) lessens the antiblastic effect of prospidine (injected intraperitoneally in the same dosage and regimen), especially in an impaired mineral metabolism, caused by adrenalectomy. The growth of sarcoma 45 was found to be retarded in bilateral adrenalectomy or thyroidectomy in rats. Epinephrectomized animals showed the entire absence of this effect in DOCA injection. In thyroidectomized and adrenalectomized animals the antiblastic effect of prospidine was more pronounced than in intact (with respect to the thyroid and adrenal gland) rats.
D000315:Adrenalectomy; D000818:Animals; D003900:Desoxycorticosterone / Q000008:administration & dosage* / Q000627:therapeutic use; D004359:Drug Therapy, Combination; D008297:Male; D009368:Neoplasm Transplantation; D010879:Piperazines / Q000008:administration & dosage*; D011447:Prospidium / Q000008:administration & dosage* / Q000627:therapeutic use; D051381:Rats; D012513:Sarcoma, Experimental / Q000628:therapy*; D013965:Thyroidectomy
D010879:Piperazines; D003900:Desoxycorticosterone; D011447:Prospidium
Vliianie 11-dexoksikortikosterona atsetata na protivoopukholevuiu aktivnost' prospidina