Effects of indomethacin and prostaglandin F2alpha on parturition in the hamster.
In the hamster administration of indomethacin twice a day on days 14 to 16 of pregnancy delayed the onset of parturition; a delay of 5 and 8 hours was observed following treatments of 300 or 600 mug/injection of indomethacin, respectively. Injection of PGF2alpha to the indomethacin treated hamsters on day 15 of pregnancy, on the other hand, advanced the onset of parturition. Treatments of indomethacin and/or PGF2alpha did not affect the duration of parturition.
D000818:Animals; D006224:Cricetinae; D005260:Female; D007213:Indomethacin / Q000494:pharmacology*; D007743:Labor, Obstetric / Q000187:drug effects*; D011247:Pregnancy; D011460:Prostaglandins F / Q000494:pharmacology*
D011460:Prostaglandins F; D007213:Indomethacin