title: A quantitative evaluation of anticoagulants in experimental nephrotoxic nephritis.
abstract: The protective effects of anticoagulants in nephrotoxic nephritis in rabbits have been studied, using various doses of heparin and defibrination with ancrod. Massive doses of heparin (2000 units/kg/day) were required before significant reduction in glomerular fibrin deposition, extracepillary cell proliferation and urea retention occurred. Doses of 300 and 1000 units/kg/day were insufficient to modify fibrin deposition and cell proliferation. Defibrination with ancrod provided protection, judged by histological and functional criteria, comparable to 2000 units of heparin/kg/day; but fibrin could still be demonstrated in the glomeruli of animals treated with 2000 units of heparin/kg/day, contrasting with the virtual absence of fibrin in animals given ancrod.
mesh_terms: D000721:Ancrod / Q000627:therapeutic use*; D000818:Animals; D001485:Basement Membrane / Q000276:immunology; D001780:Blood Coagulation Tests; D003176:Complement C3; D004305:Dose-Response Relationship, Drug; D010450:Endopeptidases / Q000627:therapeutic use*; D005337:Fibrin / Q000032:analysis; D006493:Heparin / Q000627:therapeutic use*; D007074:Immunoglobulin G; D007678:Kidney Glomerulus / Q000032:analysis; D008297:Male; D009393:Nephritis / Q000188:drug therapy* / Q000276:immunology; D011817:Rabbits
chemical_list: D003176:Complement C3; D007074:Immunoglobulin G; D005337:Fibrin; D006493:Heparin; D010450:Endopeptidases; D000721:Ancrod