Induction of microbial variants of Pseudomonas pseudomallei in cultured rabbit alveolar macrophages.
Cultured alveolar and peritoneal macrophages obtained from normal and immunized rabbits were used to induce wall-defective microbial variants of Pseudomonas pseudomallei. Variants were iduced only by normal alveolar macrophages. The variants reverted to typical Pseudomonas forms either spontaneously or upon transfer into broth or agar.
D000818:Animals; D001202:Ascitic Fluid / Q000166:cytology; D002473:Cell Wall / Q000648:ultrastructure; D002478:Cells, Cultured; D014644:Genetic Variation; D007114:Immunization; D008264:Macrophages / Q000276:immunology / Q000382:microbiology*; D008554:Melioidosis / Q000382:microbiology; D011549:Pseudomonas / Q000254:growth & development / Q000648:ultrastructure*; D011650:Pulmonary Alveoli / Q000166:cytology; D011817:Rabbits