Genetic considerations of gout.
A great many genetic factors and genetic mechanisms are involved in the production of gouty arthritis. Genetic heterogeneity is to be expected in this disorder at all levels of expression. The genetic factors responsible for hyperuricemia, whether from gross overproduction of uric acid or from decreased renal excretion, can influence such practical matters as the selection of the proper therapy for control of the disease.
D000493:Allopurinol / Q000627:therapeutic use; D006073:Gout / Q000188:drug therapy / Q000235:genetics*; D006801:Humans; D007668:Kidney / Q000503:physiopathology; D011339:Probenecid / Q000627:therapeutic use
D000493:Allopurinol; D011339:Probenecid