The effects of ketamine and innovar on the renal cortical and medullary blood flow of the dog.
To study the effects of Ketamine and Innovar on renal function, the renal cortical and medullary blood flows of dog were measured using a thermo-electrical flowmeter, along with the urine output, blood pressure and pulse rate. Ketamine decreased the renal cortical blood flow and the urine output. Innovar increased the renal cortical blood flow, but did not alter the medullary blood flow appreciably, and decreased the urine output. Neither of these variations in renal blood flows ran parallel with variations in the arterial pressure nor did variations in the urine output run parallel with those in the blood flows. All anaesthetic agents are inhibitory to kidney, but Innovar may be preferred to other anaesthetics in view of the finding that the renal blood flows are well maintained even under anaesthesia with this agent.
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D004285:Dogs; D004329:Droperidol / Q000494:pharmacology*; D004338:Drug Combinations; D005283:Fentanyl / Q000494:pharmacology*; D007649:Ketamine / Q000494:pharmacology*; D007668:Kidney / Q000187:drug effects*; D007672:Kidney Cortex / Q000098:blood supply; D007679:Kidney Medulla / Q000098:blood supply; D011674:Pulse / Q000187:drug effects; D012039:Regional Blood Flow / Q000187:drug effects; D014554:Urination / Q000187:drug effects
D004338:Drug Combinations; D007649:Ketamine; D004329:Droperidol; D005283:Fentanyl