On the influence of chloramphenicol on the induction of lung adenomas by urethane in mice.
It has been shown by a number of authors that the antibiotic chloramphenicol (CP), produced in the USSE under the name of levomycetin, had considerably inhibited the growth of liver tumors, induced by various carcinogenic compounds [3,7,8,21]. Moreover, it has been found by ourselves and other authors that CP greatly reduces the toxic effect of carcinogenic polycyclic hydrocarbons on cultures of embryonic fibroblasts of mice and the adrenals of rats [5,9,20,23]. As the full extent of the antiblastomogenic activity of CP has so far not been studied, it was important to elucidate its influence on other groups of chemical carcinogens. In experiments described in the present paper we have investigated the influence of CP on the incidence of lung adenomas in mice after administration of urethane.
D000236:Adenoma / Q000139:chemically induced*; D000818:Animals; D002701:Chloramphenicol / Q000494:pharmacology*; D004347:Drug Interactions; D005260:Female; D008175:Lung Neoplasms / Q000139:chemically induced*; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D009374:Neoplasms, Experimental / Q000139:chemically induced; D014520:Urethane
D014520:Urethane; D002701:Chloramphenicol