[ABO blood-group phenotypes and pathogenesis of cardiovascular diseases. Congenital, rheumatic and coronaric heart disease and arterial hypertension (author's transl)].
Many cases of cardiovascular diseases have been examined in reference to the distribution of ABO blood-groups, in order to calculate the relative risk of disease and the hemogroupal distributive significance in our samples as related to those of other authors, using combined calculation. The analysis concerned the following cases: 746 with arterial hypertension, 3258 with congenital heart disease, 4503 with articular rheumatism, 1047 with acquired valvulopathia, and respective controls. It was found that blood-group phenotypes represent an important biophysiopathological action in regard to articular rheumatism and its cardiac consequences, in myocardial infarction and in hypertension, males only. On the contrary, no action in regard to congenital heart disease was found, with the exception of some single anomalies which have yet to be confirmed. This hemogroupal action greatly exceeds the one limited to the immunitary analogy and is a noticeable part of family heredity. It shows itself in: -- a significant negative association with group O and positive association with group A in the myocardial infarction; -- a significant negative association with group O and positive for the others in the valvulopathic (rheumatic) diseases; -- a positive association with A phenotype and negative with B in arterial hypertension, males only; -- no association with ABO blood-groups and congenital heart disease.
D000017:ABO Blood-Group System; D003327:Coronary Disease / Q000453:epidemiology*; D005260:Female; D006330:Heart Defects, Congenital / Q000453:epidemiology*; D006801:Humans; D006973:Hypertension / Q000453:epidemiology*; D007558:Italy; D008297:Male; D012214:Rheumatic Heart Disease / Q000453:epidemiology*
D000017:ABO Blood-Group System
Partecipazione dei fenotipi emogruppali ABO alla patogenesi delle malattie cardiovascolari. Cardiopatie congenite, reumatiche, coronariche ed ipertensione arteriosa