[Evidence for circadian variability in the renin-angiotensin II system (author's transl)].
Circadian variations of P.R.A. and angiotensin II were studied in three normal subjects and nine hypertensive patients. All data were analysed by a mathematical-statistical method called "cosinor". Analysis of results has shown: 1) Circadian rhythm of P.R.A. which in the normal subjects reaches its acrophase (maximum daily level) in the morning, while in the hypertensive patients the acrophase recurs in the afternoon; 2) Circadian rhythm of angiotensin II in the normal subjects, which is not detected in the hypertensive patients. Angiotensin I does not exhibit rhythm in both groups.
D000804:Angiotensin II / Q000097:blood*; D002940:Circadian Rhythm; D006973:Hypertension / Q000097:blood*; D006977:Hypertension, Renal / Q000097:blood; D012083:Renin / Q000097:blood*
D000804:Angiotensin II; D012083:Renin
Dimostrazione della variabilita' circadiana del sistema renina-angiotensina II