Pituitary hormone response to brain stimulation in man.
Plasma cortisol, GH and LH responses to electrical stimulation of the orbital part of the frontal lobe and the cingulate area of the brain were studied in patients undergoing limbic leucotomy. In six out of 15 patients the plasma cortisol levels increased by 5-7--18-0 mug/100 ml after orbito-frontal stimulation whereas plasma GH values did not rise during this period. Plasma LH levels remained unchanged. No definite hormone responses could be attributed to stimulation of the cingulate area. It appears that the orbito-frontal area of the brain is concerned with augmenting the release of ACTH but not that of GH or LH.
D005625:Frontal Lobe / Q000502:physiology*; D013006:Growth Hormone / Q000097:blood; D006179:Gyrus Cinguli / Q000502:physiology*; D006801:Humans; D006854:Hydrocortisone / Q000097:blood; D007986:Luteinizing Hormone / Q000097:blood; D010908:Pituitary Hormones, Anterior / Q000097:blood*; D011612:Psychosurgery
D010908:Pituitary Hormones, Anterior; D007986:Luteinizing Hormone; D013006:Growth Hormone; D006854:Hydrocortisone