[Familial autoimmune hemolytic animia (AIHA) with negative Coombs test, lymphocytopenia and hypogammaglobulinemia].
A family with several cases of autoimmune hemolytic anemia and dysgammaglobulinemia is described. Two sibling had documented antierythrocyte antibodies, but a third had repeatedly negative Coombs tests. Diminished immunoglobulin-producing cells and a hypogammaglobulinemia were found, but no functional defect of humoral or cell-mediated immunity could be detected.
D000361:Agammaglobulinemia / Q000209:etiology*; D000744:Anemia, Hemolytic, Autoimmune / Q000150:complications / Q000235:genetics*; D003298:Coombs Test; D005260:Female; D006801:Humans; D008231:Lymphopenia / Q000209:etiology*; D008297:Male; D010375:Pedigree
Familiäre autoimmunhämolytische Anämie (AIHA) mit negativem Coombs-Test, Lymphozytopenie und Hypogammaglobulinämie