Prevention of herpes keratoconjunctivitis in rabbits by silver sulfadiazine.
Silver sulfadiazine, at a concentration of 10 mug/ml when applied immediately after infection by Herpesvirus hominis, prevented the development of acute herpetic keratoconjunctivitis in rabbits. The efficacy was inversely related to the size of inoculum. Subclinical infections were observed in the drug-treated eyes.
D000818:Animals; D006561:Herpes Simplex / Q000473:pathology* / Q000517:prevention & control*; D007637:Keratoconjunctivitis / Q000473:pathology / Q000517:prevention & control*; D011817:Rabbits; D012834:Silver / Q000627:therapeutic use*; D013411:Sulfadiazine / Q000627:therapeutic use*
D013411:Sulfadiazine; D012834:Silver