Effects of d-amphetamine on the incorporation of carbon atoms of D-glucose into the brains of differentially-housed mice.
Mice were housed either individually ("isolated") or in groups of 20-25 ("aggregated") for 5-9 weeks or for 22 weeks. A decreased incorporation of radioactivity into brain from subcutaneously-administered U-14C-D-glucose occurred in "isolated" mice as compared to grouped animals. Amphetamine, administered before labelled glucose, produced a dose-dependent decrease of radioactivity which was selective to the brains of the "isolated" mice. The data support the correlation between isolation-induced changes in behavior and central metabolic pathways and indicate further that these changes may be altered by administration of psycho-active agents.
D000818:Animals; D001921:Brain / Q000187:drug effects* / Q000378:metabolism; D003441:Crowding; D003913:Dextroamphetamine / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D004777:Environment; D005947:Glucose / Q000378:metabolism*; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D012934:Social Isolation
D005947:Glucose; D003913:Dextroamphetamine