title: [Universal approaches to the control of tissue radiosensitivity during radiation therapy of malignant tumors].
abstract: Approaches to the problem of the control over tissue radiosusceptibility, united by the common purpose--a need for selective increase of the intact tissues tolerance to overcome tumor hypoxia, are discussed. Such universal approaches include an application of radiation characterized by high linear wastes of radiation energy, methods of increased oxygenation of tumors, the use of electron sink compounds, and irradiation under conditions of hypoxia--hypoxiradiotherapy. The experiments conducted by the author and his collaborators with local irradiation of a number of transplantable mice tumors under general hypoxia, produced by inhalation of oxygen poor gaseous mixtures (5% O2+95% N2), have shown not only a selective protection of normal tissues, but also greater regression of tumors. The mechanism of the observed phenomenon is being suggested, and some prospects of hypoxiradiotherapy in the oncological clinic are discussed.
mesh_terms: D000818:Animals; D002286:Carcinoma, Ehrlich Tumor / Q000532:radiotherapy; D005720:Gamma Rays; D006931:Hyperbaric Oxygenation; D051379:Mice; D008815:Mice, Inbred Strains; D009369:Neoplasms / Q000532:radiotherapy*; D009502:Neutrons; D010100:Oxygen; D011838:Radiation-Sensitizing Agents / Q000627:therapeutic use*; D011878:Radiotherapy / Q000379:methods*; D012511:Sarcoma 37 / Q000532:radiotherapy; D012513:Sarcoma, Experimental / Q000532:radiotherapy
chemical_list: D011838:Radiation-Sensitizing Agents; D010100:Oxygen
vernacular_title: Universal'nye podkhody k upravleniiu tkanevoĭ radiochuvstvitel'nost'iu pri luchevoĭ terapii zlokachestvennykh opukholeĭ