title: Rapidly reversible depression of delayed hypersensitivity in two children with visceral leishmaniasis.
abstract: Two cases of visceral leishmaniasis in children are described. In both "in vitro" lymphocyte response to mitogens and allogeneic cells was initially markedly depressed, but returned to normal within a few days after six days of treatment with N-methylglucamine antimonate; in one the candidin skin test reverted from negative to positive after treatment and in the other a circulating serum factor was found which strongly inhibited phytohemagglutinin--and mixed--responsiveness of normal lymphocytes, but disappeared after therapy.
mesh_terms: D000606:Amino Sugars / Q000627:therapeutic use; D000965:Antimony / Q000627:therapeutic use; D002675:Child, Preschool; D005260:Female; D006801:Humans; D006968:Hypersensitivity, Delayed / Q000276:immunology*; D007165:Immunosuppression Therapy; D007898:Leishmaniasis, Visceral / Q000276:immunology*; D008213:Lymphocyte Activation; D008297:Male; D012882:Skin Tests
chemical_list: D000606:Amino Sugars; D000965:Antimony