Hemoglobin synthesis studies of a family with alpha-thalassemia trait and sickle cell trait.
The ratio of total globin alpha to beta chain synthesis was determined in reticulocytes isolated from the blood of the members of a black family, some of whom had sickle cell trait with low blood HbS concentrations (25-30%). The results support the hypothesis that sickle cell trait individuals with low HbS concentrations also carry a gene for alpha-thalassemia.
D000755:Anemia, Sickle Cell / Q000097:blood*; D005260:Female; D006451:Hemoglobin, Sickle / Q000096:biosynthesis*; D006454:Hemoglobins / Q000096:biosynthesis*; D006455:Hemoglobins, Abnormal / Q000096:biosynthesis*; D006801:Humans; D008297:Male; D010375:Pedigree; D012156:Reticulocytes / Q000378:metabolism; D012805:Sickle Cell Trait / Q000097:blood* / Q000150:complications / Q000235:genetics; D013789:Thalassemia / Q000097:blood* / Q000150:complications / Q000235:genetics
D006451:Hemoglobin, Sickle; D006454:Hemoglobins; D006455:Hemoglobins, Abnormal