Diphenylhydantoin: action of a common anticonvulsant on bursting pacemaker cells in Aplysia.
A commonly used anticonvulsant, diphenylhydantoin (Dilantin), decreases the bursting pacemaker activity in certain cells of Aplysia. Dilantin decreases this bursting activity whether it is endogenous to the cell or induced by a convulsant agent. The sodium-dependent negative resistance characteristic which is essential for bursting behavior is reduced in the presence of Dilantin.
D000200:Action Potentials / Q000187:drug effects*; D000818:Animals; D001692:Biological Transport; D008564:Membrane Potentials / Q000187:drug effects; D008954:Models, Biological; D008974:Mollusca; D009474:Neurons / Q000187:drug effects* / Q000378:metabolism / Q000502:physiology; D012640:Seizures / Q000503:physiopathology; D012964:Sodium / Q000378:metabolism
D012964:Sodium