[Ultrastructural study of the activity of phospholipids in experimental liver damage induced by isoniazide].
The authors studied the activity of egg-derived phospholipids on the hepatotoxic effect induced in rats by isoniazid (INH) given orally for 20 consecutive days in doses of 25, 50 and 100 mg/kg/day. In the animals treated with the highest dose of INH, a great number of liver cells showed structural and ultrastructural changes. Their hyaloplasm was more electron-dense, the cytoplasmic structure was condensed and collapsed, without apparent endoplasmic reticulum and ribosomes. A very different structural and ultrastructural picture was observed in the animals treated with INH + phospholipids. The structure was quite normal without degenerating cells. There was a greater richness of endoplasmic reticulum, ribosomes and glycogen particles.
D000818:Animals; D056486:Chemical and Drug Induced Liver Injury / Q000209:etiology / Q000517:prevention & control*; D004721:Endoplasmic Reticulum / Q000187:drug effects; D005260:Female; D007538:Isoniazid / Q000009:adverse effects*; D008099:Liver / Q000187:drug effects / Q000648:ultrastructure*; D008297:Male; D010743:Phospholipids / Q000494:pharmacology* / Q000627:therapeutic use; D051381:Rats; D012270:Ribosomes / Q000187:drug effects
D010743:Phospholipids; D007538:Isoniazid
Studio ultrastrutturale sul'attività dei fosfolipidi nelle lesioni epatiche sperimentali indotte da isoniazide