[Ontogenic properties of ketone body metabolism in pig tissues].
When incubating the liver slices of pig fetuses in the Krebs-Ringer phosphate buffer without substrates and with addition of butyrate and acetate a considerably lesser amount of ketone bodies is formed than with incubation of the liver slices of adult pigs. Therefore, a higher level of the ketone bodies in blood and tissues of the fetuses as compared to adult pigs is not due to ketogenesis in their liver, but is a result of their entering from the mother or formation in the placenta. When incubated in the above-mentioned medium the fetus skeletal muscle slices utilize exogenous acetoacetate in a significantly more quantity than the muscle slices of the adult animals. The liver and skeletal muscle slices of the fetuses reduce endogenous and exogenous acetoacetate into beta-hydroxybutyrate more intensively as compared to slices of the same tissues of the adult animals.
D000085:Acetates / Q000378:metabolism; D000090:Acetoacetates / Q000378:metabolism; D000375:Aging; D000818:Animals; D002087:Butyrates / Q000378:metabolism; D005333:Fetus; D006885:Hydroxybutyrates / Q000378:metabolism; D066298:In Vitro Techniques; D007657:Ketone Bodies / Q000378:metabolism*; D008099:Liver / Q000254:growth & development / Q000378:metabolism*; D024510:Muscle Development; D009132:Muscles / Q000378:metabolism*; D013552:Swine
D000085:Acetates; D000090:Acetoacetates; D002087:Butyrates; D006885:Hydroxybutyrates; D007657:Ketone Bodies