title: Fluctuations of plasma phenytoin levels on single dose and twice daily dose regimes.
abstract: Eight chronic refractory epileptics were studied with regard to frequency of administration of phenytoin. There were no excessive fluctuations in plasma levels when the total drug dose was given as a single daily dose, and the clinical state of the patients was unchanged from that on twice daily dosage.
mesh_terms: D000293:Adolescent; D000328:Adult; D002648:Child; D002908:Chronic Disease; D004334:Drug Administration Schedule; D004827:Epilepsy / Q000097:blood* / Q000188:drug therapy; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010672:Phenytoin / Q000008:administration & dosage / Q000097:blood* / Q000627:therapeutic use
chemical_list: D010672:Phenytoin