Microaggregate formation during regional hypoperfusion.
Occlusion of the infrarenal aorta in the dog is associated with formation of microaggregates. Etiologic factors involve stasis, acidosis and hypoperfusion. Upon restoration of flow, microaggregates are transported through the inferior vena cava to the pulmonary circulation as microemboli. The volume of microaggregates appearing in the inferior vena cava after restoration of flow in our experiments is small and seems inadequate to cause significant pulmonary mechanical obstruction. The vasoactivity of these microparticles, although to date unknown, may be significant in the etiology of the pulmonary alterations which were described previously.
D000818:Animals; D001012:Aorta, Abdominal; D001157:Arterial Occlusive Diseases / Q000097:blood*; D001775:Blood Circulation; D004195:Disease Models, Animal; D004285:Dogs; D005260:Female; D008026:Ligation; D008297:Male; D011655:Pulmonary Embolism / Q000209:etiology*