Effect of sex hormones on uric acid metabolism in rats.
The effects of sex hormones on purine metabolism were investigated in rats. No influence on purine synthesis was shown by the injection of estrogen and androgen. The plasma urate levels were significantly lowered from 2.43 +/- 1.04 mg/100 ml to 1.53 +/- 0.57 mg/100 ml by the injection of progesterone. Urinary excretion of uric acid plus allantoin was slightly reduced. These results suggested that progesterone may influence age and sex differences in human plasma urate levels.
D000481:Allantoin / Q000652:urine; D000728:Androgens / Q000494:pharmacology*; D000818:Animals; D004967:Estrogens / Q000494:pharmacology*; D005260:Female; D008297:Male; D011374:Progesterone / Q000494:pharmacology*; D051381:Rats; D014527:Uric Acid / Q000097:blood / Q000378:metabolism* / Q000652:urine
D000728:Androgens; D004967:Estrogens; D014527:Uric Acid; D000481:Allantoin; D011374:Progesterone