[Mechanism of the action aminopyrine].
In acute experiments on unanesthetized cats with a single and paired stimulation the effect of aminopyrine (5-30 mg/kg, intravenously) on bioelectric reactions in the conduction system of afferent impulsation at the thalamo-cortical level was studied. Aminopyrine is shown to highten the amplitude of an evoked potential of the somato-sensory cortex and of the specific transmitting nucleus of the thalamus upon stimulation of the radial nerve and to significantly lengthen with paired stimulation the regeneration period of the neuronic systems excitability in the structures under review. Investigations into the states of the cortical neuronic systems proper showed aminopyrine capable of increasing the number of high-frequency oscillations and the amplitude of the interzonal response as well as to lengthen with paired stimulation the restoration period of the neuronic systems excitability.
D000632:Aminopyrine / Q000494:pharmacology*; D000818:Animals; D002415:Cats; D002540:Cerebral Cortex / Q000187:drug effects*; D004558:Electric Stimulation; D005071:Evoked Potentials / Q000187:drug effects; D009431:Neural Conduction / Q000187:drug effects; D011826:Radial Nerve / Q000502:physiology; D012032:Refractory Period, Electrophysiological / Q000187:drug effects; D013788:Thalamus / Q000187:drug effects*
D000632:Aminopyrine
O mekhanizme deĭstviia amidopirina