title: Diagnosis of ventricular septal defect in acute myocardial infarction without cardiac catheterization.
abstract: Five patients with acute myocardial infarction and a systolic murmur suggestive of ventricular septal rupture or mitral regurgitation have been examined by external vascular isotope dilution curves over the chest after i.v. injection of 125I-hippuran. In three patients these isotope dilution curves showed signs of left-to-right shunting of blood, and subsequent autopsy demonstrated the presence of ventricular septal defect. In two patients there was no sign of left-to-right shunting, and these patients recovered.
mesh_terms: D000368:Aged; D005260:Female; D006345:Heart Septal Defects, Ventricular / Q000150:complications / Q000175:diagnosis*; D006801:Humans; D007457:Iodine Radioisotopes; D007465:Iodohippuric Acid; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000150:complications*; D012588:Scintillation Counting
chemical_list: D007457:Iodine Radioisotopes; D007465:Iodohippuric Acid