title: [Comparison of anticholinesterase activity and the effectiveness of anticholinesterase substances].
abstract: In vitro tests set up to compare the anticholinesterase, cholinomimetic, cholinopotentiating and cholinolytic activity of 6 reversible cholinesterase inhibitors furnished grounds for an inference that all these agents produce an anticholinesterase effect which determines the qualitative specificity of their action. This specificity has been demonstrated in experiments on cats and rabbits. Some of the drugs (oxazyl) exert a practically elective effect on the H-cholinoreactive muscle systems, whereas others (eserin) act in a similar manner on the M-cholinoreactive systems of the intestines. The action of proserine and galanthamine os of a less selective nature.
mesh_terms: D000549:Ambenonium Chloride / Q000494:pharmacology; D000818:Animals; D001921:Brain / Q000187:drug effects*; D002415:Cats; D002800:Cholinesterase Inhibitors / Q000494:pharmacology; D004353:Drug Evaluation, Preclinical; D005702:Galantamine / Q000494:pharmacology; D007421:Intestine, Small / Q000187:drug effects*; D009132:Muscles / Q000187:drug effects*; D009388:Neostigmine / Q000494:pharmacology; D010830:Physostigmine / Q000494:pharmacology; D011817:Rabbits; D051381:Rats
chemical_list: D002800:Cholinesterase Inhibitors; D005702:Galantamine; D009388:Neostigmine; D000549:Ambenonium Chloride; D010830:Physostigmine
vernacular_title: Sopostavlenie antikholinesteraznoĭ aktivnosti i effektivnosti antikholinesteraznykh sredstv