Synthesis and biological evaluation of potential hypoglycemic agents I: Carnitine analogs.
A series of 4-dialkylamino-3-hydroxybutyric acid hydrochlorides and methochlorides, analogs of carnitine, was synthesized by treatment of tert-butyl 3,4-epoxybutyrate with the appropriate amine or amine hydrochloride in methanol followed by mild acid hydrolysis. The compounds had no effect on blood glucose or serum fatty acid levels in rats.
D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D002331:Carnitine / Q000031:analogs & derivatives* / Q000494:pharmacology; D005230:Fatty Acids, Nonesterified / Q000097:blood; D007004:Hypoglycemic Agents / Q000138:chemical synthesis / Q000494:pharmacology; D008297:Male; D051381:Rats
D001786:Blood Glucose; D005230:Fatty Acids, Nonesterified; D007004:Hypoglycemic Agents; D002331:Carnitine