A computer program for deriving the rate equations of enzyme catalysed reactions with unbranched mechanisms.
This paper describes a simple program for a desk-top computer which determines the relative concentrations of enzyme-containing intermediates appearing in an enzyme catalysed reaction where the intermediates lie in an unbranched sequence originating and terminating in one enzyme intermediate. This information, the distribution function, then gives the rate equation by the usual means (Wong and Hanes, 1962). The method is rapid and has the advantage that the distribution function may be presented in its complete form or in terms of its dependence on the concentration of the substrates and products. It is also possible to determine the effects of dead-end inhibition.
D003201:Computers; D004798:Enzymes / Q000378:metabolism*; D007700:Kinetics
D004798:Enzymes