Marihuana-like activity of new synthetic tetrahydrocannabinols.
11-Methy-delta8-, 9-nor-delta8, and 9-nor-delta9-tetrahydrocannabinol (THC), newly synthesized cannabinoids which are not 11-hydroxyated in vivo, were tested for cannabinoid activity. Delta8-, delta9-THC and each synthetic analog produced static ataxia in unanesthetized dogs, hypotension and bradycardia in anesthetized dogs, and decreased spontaneous activity in mice. All synthetic analogs tested produced a greater degree of tolerance to the behavioral effect in dogs than did delta8-THC. 11-Methyl-delta8-THC was more effective than delta8-THC in decreasing spontaneous activity in mice, but was less active in producing the behavioral and cardiovascular effects in dogs. 9-nor-delta9-THC was less active than delta9-TCH, but 9-nor-delta8-THC was as active as delta8-THC in all observations. These results suggest that the 11-hydroxy metabolites of delta8- and delta 9-THC are not solely responsible for the biological activity of tetrahydrocannabinol.
D000700:Analgesics; D000818:Animals; D001259:Ataxia / Q000139:chemically induced; D001522:Behavior, Animal / Q000187:drug effects; D001794:Blood Pressure / Q000187:drug effects; D002188:Cannabis / Q000494:pharmacology*; D004285:Dogs; D013759:Dronabinol / Q000031:analogs & derivatives / Q000378:metabolism / Q000494:pharmacology*; D005260:Female; D006339:Heart Rate / Q000187:drug effects; D006591:Hexobarbital / Q000494:pharmacology; D008297:Male; D051379:Mice; D009043:Motor Activity / Q000187:drug effects; D011809:Quinones / Q000037:antagonists & inhibitors; D011930:Reaction Time / Q000187:drug effects; D012890:Sleep / Q000187:drug effects
D000700:Analgesics; D011809:Quinones; D013759:Dronabinol; D006591:Hexobarbital