Effects of local anaesthetics on calcium transport by canine cardiac microsomes (fragmented sarcoplasmic reticulum).
Local anaesthetics inhibit calcium transport by cardiac sarcoplasmic reticulum. However, the concentrations of lidocaine and procaineamide needed to produce these effects are high. No significant differences were found between these agents that could account for reported differences in their electrophysiological effects.
D000779:Anesthetics, Local / Q000494:pharmacology*; D000818:Animals; D001693:Biological Transport, Active / Q000187:drug effects; D002118:Calcium / Q000037:antagonists & inhibitors / Q000378:metabolism*; D003992:Dibucaine / Q000494:pharmacology; D004285:Dogs; D006321:Heart / Q000187:drug effects*; D066298:In Vitro Techniques; D008012:Lidocaine / Q000494:pharmacology; D008861:Microsomes / Q000187:drug effects / Q000378:metabolism; D009206:Myocardium / Q000378:metabolism / Q000648:ultrastructure; D010070:Oxalates / Q000378:metabolism; D011342:Procainamide / Q000494:pharmacology; D012519:Sarcoplasmic Reticulum / Q000187:drug effects* / Q000378:metabolism; D013748:Tetracaine / Q000494:pharmacology
D000779:Anesthetics, Local; D010070:Oxalates; D013748:Tetracaine; D008012:Lidocaine; D011342:Procainamide; D003992:Dibucaine; D002118:Calcium