[Treatment of pseudomonas infection following burn injuries with specific antitoxic Ig-therapy].
The mortality rate of mice after standardized Pseudomonas infection was increased by preinjection of a sublethal dose of burn toxin. This effect was eliminated by a specific antitoxic Ig. After a sublethal burn followed by infection, 60% of the animals died, while treatment with specific Ig reduced the mortality rate to 3.3%. This might be a new way to improve the treatment of severely burned patients.
D000818:Animals; D000992:Antitoxins / Q000627:therapeutic use*; D002056:Burns / Q000150:complications; D007136:Immunoglobulins / Q000627:therapeutic use*; D051379:Mice; D011552:Pseudomonas Infections / Q000150:complications / Q000188:drug therapy* / Q000401:mortality; D014946:Wound Infection / Q000188:drug therapy*
D000992:Antitoxins; D007136:Immunoglobulins
Die Beeinflussung der Pseudomonas-Infektion nach Verbrennungstrauma durch spezifische antitoxische Ig-Behandlung