[The role of the caudate nucleus in the development of convulsive discharges].
A single or rhythmical (1-3/sec) stimulation of the caudate nucleus in unrestrained rats facilitated formation of slow negative waves and the spike-wave complexes in the EEG of the sensory-motor cortex and contralateral neostriatum, as well as development of behavioral disturbances due to subseisure doses of pentylentetrazol. During the low-frequency stimulation of the caudate nucleus or after its cessation, when giving the convulsant drug, regular potentials of the spike-wave type or a general seizure may occur. The caudate nucleus is supposed to be able to participate in the petit mal seizure mechanisms because of its syndhronizing influences on the cortex.
D000818:Animals; D002421:Caudate Nucleus / Q000503:physiopathology*; D004558:Electric Stimulation; D004594:Electrophysiology; D008297:Male; D009044:Motor Cortex / Q000503:physiopathology; D010433:Pentylenetetrazole; D051381:Rats; D012640:Seizures / Q000139:chemically induced / Q000503:physiopathology*; D013003:Somatosensory Cortex / Q000503:physiopathology
D010433:Pentylenetetrazole
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