title: Experimental ulcerative disease of the colon.
abstract: The oral administration to guinea-pigs of an aqueous solution of carrageenan derived from the red seaweed, Eucheuma spinosum, provides a useful, readily available experimental model for the study of ulcerative disease of the colon. Two types of ulcerative disease can be produced within a 4-6 week period, viz., ulceration localised mainly to the caecum by using 1% undegraded carrageenan in the drinking fluid, and extensive ulceration involving caecum, colon, and rectum by using 5% degraded carrageenan. Ulceration is probably due to the local action of carrageenan in the bowel.
mesh_terms: D000818:Animals; D002351:Carrageenan; D003092:Colitis / Q000473:pathology; D003093:Colitis, Ulcerative / Q000139:chemically induced; D003106:Colon / Q000473:pathology; D003424:Crohn Disease / Q000139:chemically induced; D004195:Disease Models, Animal; D006168:Guinea Pigs; D006801:Humans; D008297:Male
chemical_list: D002351:Carrageenan