N-acetyl-beta-glucosaminidase activity in normal and malignant leukocytes.
An improved cytochemical method demonstrating N-acetyl-beta-glucosaminidase in peripheral blood and bone marrow leukocytes is described. A significant elevation in enzyme activity in circulating monocytes from patients with solid tumor malignancies was observed. In a large series of cases of acute nonlymphocytic leukemia, elevated levels were found in the vast majority of those leukemias that had a predominant monocytic component identified either morphologically or by standard cytochemical methods. This reaction would appear to be useful as a monocyte marker.
D000118:Acetylglucosaminidase / Q000097:blood / Q000378:metabolism*; D001853:Bone Marrow / Q000201:enzymology; D001854:Bone Marrow Cells; D006098:Granulocytes / Q000201:enzymology; D006596:Hexosaminidases / Q000378:metabolism*; D006651:Histocytochemistry; D006801:Humans; D007938:Leukemia / Q000201:enzymology / Q000473:pathology; D007962:Leukocytes / Q000201:enzymology* / Q000648:ultrastructure; D008533:Megakaryocytes / Q000201:enzymology; D009000:Monocytes / Q000201:enzymology; D009369:Neoplasms / Q000201:enzymology*
D006596:Hexosaminidases; D000118:Acetylglucosaminidase