[Influence of the long-term administration of barbiturates on the structural-functional characteristics of the uterine epithelium].
By using histological, histochemical and electron-microscopic methods it is shown that upon administration of phenobarbital, nembutal and sodium barbital to albino mice for a space of 5 and 25 days there occur changes in the metabolic and synthetic processes in the endometrium, which with a short-term action become manifest in inhibition and with their prolonged application--in activation of these processes. There are available data that bear proof to the appearance of signs pointing to destruction occurring in the uterine epithelium secondary to the introduction of the said agents.
D000818:Animals; D001462:Barbital / Q000633:toxicity; D001463:Barbiturates / Q000633:toxicity*; D004717:Endometrium / Q000187:drug effects*; D004848:Epithelium / Q000187:drug effects; D005260:Female; D051379:Mice; D010424:Pentobarbital / Q000633:toxicity; D010634:Phenobarbital / Q000633:toxicity
D001463:Barbiturates; D001462:Barbital; D010424:Pentobarbital; D010634:Phenobarbital
Vliianie dlitel'nogo vvedeniia barbituratov na strukturno-funktsional'nuiu kharakteristiku épiteliia matki