[Influence of some antifeine derivatives on the acid-base properties and the electrolyte balance of the blood].
The effect of antifeine and of its alkyl derivatives-aethimizool, etherfil and the preparation 163-on the acid-base equilibrium (ABE) and the electrolytes balance of blood in rabbits was studied. Antifeine, aethimizol and ethefil were found to produce a mixed character of disturbances involving the metabolic and respiratory components of the ABE. The preparation 163 changed the respiratory component of the ABE alone. The blood electrolytes shifts in rabbits depended also on the features specific for the chemical structure of the substances.
D000136:Acid-Base Equilibrium / Q000187:drug effects*; D000818:Animals; D006993:Hypnotics and Sedatives / Q000494:pharmacology*; D007093:Imidazoles / Q000494:pharmacology*; D011188:Potassium / Q000097:blood*; D011817:Rabbits; D012964:Sodium / Q000097:blood*
D006993:Hypnotics and Sedatives; D007093:Imidazoles; D012964:Sodium; D011188:Potassium
Vliianie nekotorykh proizvodnykh atifeina na kislotno-shchelochnye svoĭstva i élektrolitnyĭ balans krovi