[Circadian variations in the response of corneal epithelial cells in mice to the effects of vinblastine].
A drop of a 0.2% vinblastin solution was applied to the eye cornea of mouse at 7 a.m. and at 7 p.m. The cornea of the second eye of the same animal served as control (application of physiological saline). The animals were sacrificed three hours after the application. The results of two analogous experiments showed vinblastin application to cause more expressed statmokinetic reaction in the corneal epithelium in the evening than in the morning hours. The percentage of K-mitoses was also higher in the evening.
D000818:Animals; D002940:Circadian Rhythm; D004848:Epithelium; D051379:Mice; D014747:Vinblastine / Q000494:pharmacology*
D014747:Vinblastine
Sutochnye kolebaniia reaktsii kletok épiteliia rogovitsy u mysheĭ na deĭstviia vinblastina