Effect of secretin on intestinal monosaccharide absorption and new water movement in the rat.
Repeated intravenous injections of 2.0 clinical units (CU) secretin per kg body weight showed no effect on jejunal glucose absorption and net water movement in perfusion studies in vivo. The in vitro uptake of galactose and 3-O-methylglucose was not altered by a secretin load given 12 min before sacrifice. The values for Km and Vmax were identical after secretin and in a control group. The conflicting results of different authors concerning the effect of secretin on net water movement and solute absorption may be due to differences in experimental techniques, different, mostly pharmacological doses of the hormone, and a diverse response of heterogeneous species.
D000818:Animals; D001693:Biological Transport, Active / Q000187:drug effects; D001834:Body Water / Q000378:metabolism*; D005260:Female; D007408:Intestinal Absorption / Q000187:drug effects*; D007413:Intestinal Mucosa / Q000378:metabolism; D008757:Methylglucosides / Q000378:metabolism*; D008759:Methylglycosides / Q000378:metabolism*; D010477:Perfusion; D051381:Rats; D012633:Secretin / Q000494:pharmacology*
D008757:Methylglucosides; D008759:Methylglycosides; D012633:Secretin