[Sodium and water balance and renal function in volume expanded dogs under neuroleptanalgesia (author's transl)].
In 8 volume expanded dogs with an equilibrium between input and renal output of sodium and water neuroleptanalgesia of 6 hours duration with a total of 9 mg/kg of droperidol and 0.35 mg/kg of fentanyl was performed. Under anaesthesia GFR was increased by about 10% (p less than 0,02) compared with the conscious state, whilst renal sodium and water excretion was reduced by about 50%. From this we conclude that active tubular transport of sodium is augmented under neuroleptanalgesia. Due to decreased excretion, retention of sodium and water increased during anaesthesia changes of functional ECFV tending into the same direction. Plasma volume and intravascular protein did not change under neuroleptanalgesia compared with the conscious state. Urine osmolality and negative free water clearance (TcH2O) increased by about 60% under droperidol and fentanyl. In volume expanded dogs under neuroleptanalgesia intravenous application of 0.5-1.0 mg of atropine resulted in a temporary water diuresis.
D000818:Animals; D001285:Atropine / Q000494:pharmacology; D001794:Blood Pressure / Q000187:drug effects; D004231:Diuresis / Q000187:drug effects; D004285:Dogs; D004329:Droperidol / Q000008:administration & dosage / Q000494:pharmacology; D004347:Drug Interactions; D005260:Female; D005283:Fentanyl / Q000494:pharmacology; D005919:Glomerular Filtration Rate / Q000187:drug effects; D007668:Kidney / Q000187:drug effects; D007684:Kidney Tubules / Q000187:drug effects / Q000378:metabolism; D009458:Neuroleptanalgesia / Q000009:adverse effects; D009609:Nitrous Oxide; D010197:Pancuronium; D012964:Sodium / Q000378:metabolism*; D014556:Urine / Q000378:metabolism; D014882:Water-Electrolyte Balance
D001285:Atropine; D012964:Sodium; D010197:Pancuronium; D009609:Nitrous Oxide; D004329:Droperidol; D005283:Fentanyl
Natrium- und Wasserbilanz beim Hund im Wachzustand und unter verschiedenen Narkosebedingungen. III. Mitteilung: Neuroleptoanalgesie