Bioavailability of two carbamazepine preparations during chronic administration to epileptic patients.
Two preparations of carbamazepine, as tablets and in syrup, were given for 8 weeks to 20 patients with epilepsy in a randomized crossover study. Weekly plasma levels were 3-21 mg/1 on dosages of 5-24 mg/kg/day. There was no difference in absorption or steady-state level between the two preparations. Carbamazepine 10, 11-oxide was constantly present when the level of carbamazepine was over 5 mg/l, and tended to be lower with the syrup.
D000284:Administration, Oral; D000328:Adult; D001682:Biological Availability; D002220:Carbamazepine / Q000008:administration & dosage* / Q000009:adverse effects / Q000097:blood; D002648:Child; D004827:Epilepsy / Q000188:drug therapy*; D006801:Humans; D008297:Male; D013535:Suspensions; D013607:Tablets; D013997:Time Factors
D013535:Suspensions; D013607:Tablets; D002220:Carbamazepine