[Familial hemolytic-uremic syndrome with normal renal biopsy].
Five children from 3 different families, presented several attacks of hemolytic-uremic syndrome with peculiar features:--in 4/5 children the disease was familial; 4 presented 2 attacks, the 5th 3 attacks, separated by several months or years of time-interval;--the "bouts" were constantly marked by the initial high level of reticulocytes, rapid recovery of hematuria, renal failure and thrombocytopenia;--overall, repeated biopsies of the kidney never showed any lesion of the basement membrane of the glomerular capillaries or of the arteriolar walls leading to the diagnosis of thrombotic microangiopathy;--all etiological enquiries to precise the cause of chronic hemolysis were negative.
D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007668:Kidney / Q000473:pathology*; D008297:Male; D013997:Time Factors
Syndrome hemolytique et uremique familial avec biopsie renale normale