Antiarrhythmic effect of aprindine on several types of ventricular arrhythmias.
The antiarrhythmic effect of aprindine was compared with those of lidocaine and propranolol on several ventricular arrhythmias-epinephrine arrhythmias in cats, ouabain arrhythmias in cats and guinea pigs, ischemic ventricular arrhythmias in coronary-ligated Beagle dogs. Antiarrhythmic effects of aprindine and lidocaine were observed both in ouagain and ischemic arrhythmias, but not in epinephrine arrhythmias. While propranolol had a strong antiarrhythmic effect against epinephrine and ouabain arrhythmias, it did not increase sinus beats in ischemic arrhythmias. Marked anti-arrhythmic effects of aprindine in ischemic arrhythmias were observed in dogs using either single intravenous administration (4 mg/kg) or intravenous infusion (200 mug/kg/min, 2 mg/kg). Antiarrhythmic activity of aprindine is considered to be about twice as strong as that of lidocaine, but lidocaine is less toxic in experimental animals.
D000404:Ajmaline / Q000494:pharmacology; D000818:Animals; D000889:Anti-Arrhythmia Agents; D001073:Aprindine / Q000494:pharmacology*; D002415:Cats; D004285:Dogs; D004837:Epinephrine; D005260:Female; D006168:Guinea Pigs; D006339:Heart Rate / Q000187:drug effects; D006352:Heart Ventricles / Q000187:drug effects; D007192:Indenes / Q000494:pharmacology*; D007511:Ischemia; D008012:Lidocaine / Q000494:pharmacology; D008297:Male; D010042:Ouabain; D011342:Procainamide / Q000494:pharmacology; D011433:Propranolol / Q000494:pharmacology; D011802:Quinidine / Q000494:pharmacology
D000889:Anti-Arrhythmia Agents; D007192:Indenes; D000404:Ajmaline; D010042:Ouabain; D001073:Aprindine; D008012:Lidocaine; D011433:Propranolol; D011802:Quinidine; D011342:Procainamide; D004837:Epinephrine