Behavior of erythrocytes in ternary solvent systems.
The effect of ternary solvent systems on erythrocytes was investigated. Hemolysis experiments were run at 37degree in solutions containing various amounts of water, two nonaqueous solvents, and 0.9% sodium chloride. The nonaqueous solvents were propylene glycol, polyethylene glycol 400, dimethyl sulfoxide, dimethylformamide, and tetramethylurea. Ternary diagrams based on the critical hemolytic compositions of the various ternary systems are presented.
D000328:Adult; D004121:Dimethyl Sulfoxide / Q000494:pharmacology; D004126:Dimethylformamide / Q000494:pharmacology; D004912:Erythrocytes / Q000187:drug effects*; D006461:Hemolysis / Q000187:drug effects; D006801:Humans; D066298:In Vitro Techniques; D011092:Polyethylene Glycols / Q000494:pharmacology; D011409:Propylene Glycols / Q000494:pharmacology; D012965:Sodium Chloride / Q000494:pharmacology; D012997:Solvents; D014508:Urea / Q000494:pharmacology
D011409:Propylene Glycols; D012997:Solvents; D011092:Polyethylene Glycols; D012965:Sodium Chloride; D004126:Dimethylformamide; D014508:Urea; D004121:Dimethyl Sulfoxide