[Characteristics of the bacterial component in the dynamics of the infectious process in experimental pseudotuberculosis].
A model of experimental pseudotuberculosis caused by the administration to albino mice of virulent local pseudotuberculosis strains was used to study migration of the causative agent into the macroorganism and its tropism. Experimental results permitted to establish a number of regularities attending bacterial spread. The infectious process in pseudotuberculosis began from invasion of the causative agent into the intestinal wall and the subsequent initial bacterial reproduction at the site of invasion and penetration from the intestine into the regional mesenteric lymph nodes. This was followed by rapid reproduction of the microbes in these nodes and contamination of all the organs. With comparatively low doses of the causative agent administered and adequate resistance of mice the infectious process could either stop at the phase of regional infection with regression, or, following hematogenic dissemination, pass into the phase of decline and terminate by animal recovery. Administration of massive doses of the virulent culture led to a septicemic process and death. Experimental data concerning the localization of the microbe in the macroorganism at various phases of the infectious process confirmed the enterotropic character of the pseudotuberculosis causative agent.
D000818:Animals; D004195:Disease Models, Animal; D007422:Intestines / Q000382:microbiology; D008198:Lymph Nodes / Q000382:microbiology; D051379:Mice; D012507:Sarcoidosis / Q000382:microbiology*
Kharakteristika bakterial'nogo komponenta v dinamike infektsionnogo protsessa pri éksperimental'nom psevdotuberkuleze