[Spasmolytic activity of a piperazine derivative under the code number of 4P-79].
The author examined the pharmacologic spasmolytic action of a pyperasine derivative under the code 4P-79. She examined the effect of the compound on four types of spasms, induced by acethylcholine, nicotine, histamine and serotonine on an isolated rabbit intestine. The mean effective concentrations were determined and they were compared with the mean effective concentrations of papaverine and benzylharmine, estimated in parallel experiments. It was found that 4P-79 had high spasmolytic activity, surpassing several times that of the preparations used for comparison. There was a marked antiserotonine effect on the first place. The compound was examined also on an intestine "in situ" by the method of Nikolaev Comparative experiments with papaverine and deseryl were conducted.
D000109:Acetylcholine / Q000494:pharmacology; D000818:Animals; D001464:Barium / Q000494:pharmacology; D002415:Cats; D006247:Harmine / Q000031:analogs & derivatives / Q000494:pharmacology; D006632:Histamine / Q000494:pharmacology; D066298:In Vitro Techniques; D007422:Intestines / Q000187:drug effects; D008784:Methysergide / Q000494:pharmacology; D009538:Nicotine / Q000494:pharmacology; D010208:Papaverine / Q000494:pharmacology; D010276:Parasympatholytics / Q000494:pharmacology*; D010879:Piperazines / Q000494:pharmacology*; D011817:Rabbits; D012701:Serotonin / Q000494:pharmacology
D010276:Parasympatholytics; D010879:Piperazines; D001464:Barium; D012701:Serotonin; D006247:Harmine; D009538:Nicotine; D006632:Histamine; D010208:Papaverine; D000109:Acetylcholine; D008784:Methysergide
Vurkhu spazmolitichnata aktivnost na edno piperazinovo prozvodno pod shifur 4P-79