Membrane phospholipid metabolism in the isoproterenol-induced cardiomyopathy of the rat.
Within 60 minutes after treatment with low doses of IPR (5 mg/kg), relative specific activity of cardiolipin and sphingomyelin significantly increased in the heart. Other phospholipids of the heart were not significantly changed. Relative specific activity of cardiolipin increased much later in liver and salivary gland. Activity of CTP:PA cytidyl transferase increases 40% at 1 hour following treatment with IPR. No significant change was observed in the respiratory control ratio of heart mitochondria for 2 hours following injection with IPR; however, a significant decrease was observed 24 hours after IPR.
D000818:Animals; D002308:Cardiolipins / Q000378:metabolism; D009202:Cardiomyopathies / Q000378:metabolism; D002462:Cell Membrane / Q000378:metabolism; D003568:Cytidine Monophosphate; D007545:Isoproterenol / Q000494:pharmacology*; D008099:Liver / Q000378:metabolism; D008297:Male; D008931:Mitochondria, Muscle / Q000201:enzymology / Q000378:metabolism; D009203:Myocardial Infarction / Q000139:chemically induced / Q000378:metabolism*; D009206:Myocardium / Q000378:metabolism* / Q000648:ultrastructure; D009713:Nucleotidyltransferases / Q000378:metabolism; D010085:Oxidative Phosphorylation / Q000187:drug effects; D010713:Phosphatidylcholines / Q000378:metabolism; D010743:Phospholipids / Q000378:metabolism*; D051381:Rats; D012469:Salivary Glands / Q000378:metabolism; D013109:Sphingomyelins / Q000378:metabolism; D013997:Time Factors
D002308:Cardiolipins; D010713:Phosphatidylcholines; D010743:Phospholipids; D013109:Sphingomyelins; D009713:Nucleotidyltransferases; D003568:Cytidine Monophosphate; D007545:Isoproterenol