Effect of calcitonin on carrageenan foot oedema.
The effect of salmon calcitonin (SCT) on acute inflammation was tested in carrageenan induced foot oedema of the rat. A considerable inhibition of the oedema was obtained with 20 MRC U/kg of SCT. The injection of SCT is followed by decrease of calcemia. A hypothesis of possible inhibition of prostaglandin (PG) synthesis and/or release, caused by decrease of calcemia, is advanced.
D000818:Animals; D002116:Calcitonin / Q000627:therapeutic use*; D002118:Calcium / Q000097:blood; D002351:Carrageenan; D004487:Edema / Q000139:chemically induced / Q000188:drug therapy*; D008297:Male; D011453:Prostaglandins / Q000096:biosynthesis; D051381:Rats; D013997:Time Factors
D011453:Prostaglandins; D002351:Carrageenan; D002116:Calcitonin; D002118:Calcium