An unusual pattern of testosterone metabolism in tissue associated with a keratin-filled cutaneous cyst.
Testosterone metabolism was studied in tissues associated with a keratin-filled cutaneous cyst. Instead of the 5alpha-reduced metabolites usually associated with skin steroid metabolism, considerable amounts of 5beta-reduced steroids were found. These included 5beta-androstane-3,17-dione, 17beta-hydroxy-5beta-androstan-3-one, and 5beta-androstane-3beta,17beta-diol. This change in metabolic pattern is discussed.
D000328:Adult; D015113:Androstane-3,17-diol / Q000378:metabolism; D000738:Androsterone / Q000378:metabolism; D003560:Cysts / Q000378:metabolism*; D013196:Dihydrotestosterone / Q000378:metabolism; D005043:Etiocholanolone / Q000378:metabolism; D006801:Humans; D066298:In Vitro Techniques; D007633:Keratins; D007664:Ketosteroids / Q000378:metabolism; D008297:Male; D009132:Muscles / Q000378:metabolism; D012867:Skin / Q000378:metabolism; D012871:Skin Diseases / Q000378:metabolism*; D013739:Testosterone / Q000378:metabolism*
D007664:Ketosteroids; D013196:Dihydrotestosterone; D015113:Androstane-3,17-diol; D013739:Testosterone; D007633:Keratins; D005043:Etiocholanolone; D000738:Androsterone