The effect of the prostaglandin F2alpha analogue ICI 81008 on uterine small arteries and on blood pressure.
The effects of PGF2alpha and its analogue ICI 81008 have been compared on the small arteries of the omentum uteri on the rat. The vessels measured 20-80 mum in diameter and were examined by intra-vital-microscopy. While the maximum responses of PGF2alpha and ICI 81008 were similar, the duration of the effect of ICI 81008 was significantly longer (P is less than 0.001). At 15 minutes after the administration of the drugs the effect of ICI 81008 was still almost maximal, while the PGF2alpha response disappeared.
D000818:Animals; D001158:Arteries / Q000033:anatomy & histology / Q000187:drug effects*; D001794:Blood Pressure / Q000187:drug effects*; D005260:Female; D008853:Microscopy / Q000295:instrumentation; D009119:Muscle Contraction / Q000187:drug effects; D009130:Muscle, Smooth / Q000187:drug effects; D011460:Prostaglandins F / Q000494:pharmacology*; D051381:Rats; D013997:Time Factors; D014599:Uterus / Q000098:blood supply*
D011460:Prostaglandins F