title: Congenital abnormality of pituitary-thyroid axis in spontaneously hypertensive rats (SHR) and stroke-prone rats (SPR).
abstract: In an attempt to study whether TSH abnormality was genetically determined in SHR and SPR, plasma T4, T3, TSH and prolactin concentrations were measured in the animals with intervals of 1 to 3 months. Hypertension was found in 6-month-old SHR and SPR, but it was not found in younger animals. In contrast, a decrease of plasma T3 and an increase of plasma TSH were found in 15-day-old SHR. Also, an increase of TSH was found in 1-month-old SPR in spite of normal plasma T3 concentration. These abnormalities in SHR and SPR increased progressively with age. It is suggested that thyroid-pituitary abnormality was genetically determined in SHR and SPR.
mesh_terms: D000367:Age Factors; D000818:Animals; D001794:Blood Pressure; D002561:Cerebrovascular Disorders / Q000097:blood / Q000235:genetics / Q000503:physiopathology*; D006973:Hypertension / Q000097:blood / Q000235:genetics / Q000503:physiopathology*; D008297:Male; D010902:Pituitary Gland / Q000503:physiopathology; D011388:Prolactin / Q000097:blood; D051381:Rats; D013961:Thyroid Gland / Q000503:physiopathology; D013972:Thyrotropin / Q000097:blood*; D013974:Thyroxine / Q000097:blood; D014284:Triiodothyronine / Q000097:blood
chemical_list: D014284:Triiodothyronine; D011388:Prolactin; D013972:Thyrotropin; D013974:Thyroxine