A strategy of approaching the fit of a compartmental model applied to the behaviour of aspirins in humans.
A compartmental model has been set up with five parts. Formulation and testing of the model have been performed by simultaneous experiments involving measurement of blood levels of ASA and SA for four different preparations of aspirin investigated in four different patients. The hypotheses of the present study had been based upon a four-compartment model. However, such a model did not appear to be adequate and a new model with five compartments has been substituted for the former one. The five-compartment model has led to the formulation and testing of new physiological hypotheses; it has also provided the development of a fitting method using powerful convergence algorithms. A general analytical formulation has been set up which has made it possible to circumscribe the multiple roots of the characteristic polynomial when they have to be taken into consideration.
D001241:Aspirin / Q000494:pharmacology*; D003201:Computers; D006801:Humans; D008954:Models, Biological
D001241:Aspirin