title: [Use and limitations of acute normovolemic hemodilution].
abstract: Acute normovolemic hemodilution was performed in 46 pts. before major surgical procedures 1800 ml of pt's blood were withdrawn and hct. lowered to 24.8% mean. The hct. after retransfusion averaged 31.8% while homologous blood could widely be avoided. 78% of pts tolerated a.n.h. well or sufficiently. During a.n.h. circulatory parameters remained constant while CO rose from 4.4 to 6.1 1/min. Shortly after a.n.h., in 13 cases slight, in 10 cases, however, severe side reactions occurred: rise in BP, HR and PAP, peripheral vasoconstriction with decrease of peripheral blood flow, unproportional increase of CO and ST-depression in ECG. As a reason of this centralisation reaction a sympathetic reaction and hypoxia are discussed.
mesh_terms: D000328:Adult; D000368:Aged; D001794:Blood Pressure; D001804:Blood Transfusion, Autologous / Q000009:adverse effects; D001810:Blood Volume; D006339:Heart Rate; D006400:Hematocrit; D006801:Humans; D008875:Middle Aged; D010952:Plasma Substitutes / Q000627:therapeutic use; D011674:Pulse; D012039:Regional Blood Flow; D013514:Surgical Procedures, Operative
chemical_list: D010952:Plasma Substitutes
vernacular_title: Anwendbarkeit und Grenzen der akuten normovolämischen Hämodilution