New animal model for atherosclerosis research.
Japanese quail were investigated for their utility as a model for the discovery and evaluation of anti-atherosclerosis compounds. Although they possessed suitable characteristics for a screening animal, their development of atherosclerosis was too variable to make them a practical model. A search was conducted to find a means to make quail uniformly atherosclerotic. To this end a line of quail susceptible to experimental atherosclerosis (SEA) were selectively bred. Thus, the SEA Japanese quail is a new animal model for atherosclerosis research.
D000818:Animals; D001161:Arteriosclerosis / Q000139:chemically induced / Q000178:diet therapy / Q000503:physiopathology; D002791:Cholesterol, Dietary; D002793:Cholic Acids; D003370:Coturnix; D004195:Disease Models, Animal; D004549:Elastin; D005260:Female; D006801:Humans; D008297:Male; D011784:Quail; D012737:Sex Factors; D013045:Species Specificity
D002791:Cholesterol, Dietary; D002793:Cholic Acids; D004549:Elastin