[Treatment of circulatory insufficiency in patients with ischemic heart disease with digoxin and determination of its concentration in the blood serum by radioisotope method].
The radioisotope method with Rb86 was used for determining in vitro the serum concentration of Digoxin. The study was conducted in 57 patients with cardiac insufficiency in the acute period of myocardial infarction and with post infarction cardiosclerosis. The mean values of Digoxin concentration depending on the daily maintenance dose were obtained. The direct correlation between the amount of the drug taken and the content of the drug in the blood serum was proved. Digoxin intoxication was found to develop in cases of its content exceeding the mean level for the given dosage (4 patients), however, in 2 patients signs of intoxication developed with a low concentration of Digoxin. The causes favouring the development of intoxication are discussed.
D000328:Adult; D000368:Aged; D003327:Coronary Disease / Q000097:blood / Q000188:drug therapy*; D004077:Digoxin / Q000008:administration & dosage / Q000097:blood / Q000627:therapeutic use*; D004305:Dose-Response Relationship, Drug; D004361:Drug Tolerance; D006801:Humans; D066298:In Vitro Techniques; D008297:Male; D008875:Middle Aged; D011868:Radioisotopes; D012413:Rubidium
D011868:Radioisotopes; D004077:Digoxin; D012413:Rubidium
Lechenie nedostatochnosti krovoobrashcheniia u bol'nykh ishemicheskoĭ bolezn'iu serdtsa digoksinom s opredelenim ego kontsentratsii v syvorotke krovi radioizotopnym metodom