[Correction of endocrine-metabolic disorders in oncologic patients. The effect of biguanides (phenformin and adebita), miskleron and diphenin].
The study was conducted on 40 patients previously operated upon radically for cancer of the mammary gland, uterine body, lung and colon. All patients were explored and treated during 2-14 months. As evidenced by the data obtained, biguanides proved to be mostly effective with regard to normalization of an excessive weight in oncological patients and an impared tolerance to glucose, whereas myscleron-in cases of hyperlipemia with marked hypercholesterinemia, diphenin - in a concomitant excessive production of corticosteroids. Moreover, the pharmacological drugs concerned were shown to influence also the production of gonadotropic, steroid and thyroid hormones.
D000305:Adrenal Cortex Hormones / Q000652:urine; D000368:Aged; D001645:Biguanides / Q000627:therapeutic use*; D001786:Blood Glucose / Q000032:analysis; D001835:Body Weight; D001943:Breast Neoplasms / Q000150:complications; D002026:Buformin / Q000627:therapeutic use; D002784:Cholesterol / Q000097:blood; D002994:Clofibrate / Q000627:therapeutic use; D003110:Colonic Neoplasms / Q000150:complications; D004700:Endocrine System Diseases / Q000188:drug therapy / Q000209:etiology*; D005227:Fatty Acids / Q000097:blood; D005260:Female; D013006:Growth Hormone / Q000097:blood; D006801:Humans; D007328:Insulin / Q000097:blood; D008074:Lipoproteins / Q000097:blood; D008175:Lung Neoplasms / Q000150:complications; D008875:Middle Aged; D009369:Neoplasms / Q000150:complications* / Q000378:metabolism; D010629:Phenformin / Q000627:therapeutic use; D010672:Phenytoin / Q000627:therapeutic use; D010743:Phospholipids / Q000097:blood; D014280:Triglycerides / Q000097:blood; D014527:Uric Acid / Q000097:blood; D014594:Uterine Neoplasms / Q000150:complications
D000305:Adrenal Cortex Hormones; D001645:Biguanides; D001786:Blood Glucose; D005227:Fatty Acids; D007328:Insulin; D008074:Lipoproteins; D010743:Phospholipids; D014280:Triglycerides; D014527:Uric Acid; D010672:Phenytoin; D013006:Growth Hormone; D002784:Cholesterol; D010629:Phenformin; D002994:Clofibrate; D002026:Buformin
O korrektsii éndokrinno-obmennykh narusheniĭ u onkologicheskikh bol'nykh. Effekt biguanidov (fenformina i adebita), misklerona i difenina