The metabolism of azidomorphine in the rat.
The metabolism of [7,8-3H]azidomorphine and the in vivo stability of the azidogroup in azidomorphine and 14-hydroxyazidomorphine was studied. Asidomorphine conjugates with glucuronic acid, and is N-demethylated by rat liver microsomes. Detection by means of infrared spectroscopy proved that the azidroup in azidomorphine and 14-hydroxyazidomorphine strongly resists biotransformation in the rat.
D000818:Animals; D001386:Azides / Q000378:metabolism*; D055598:Chemical Phenomena; D002621:Chemistry; D005965:Glucuronates / Q000378:metabolism; D007279:Injections, Subcutaneous; D008297:Male; D008862:Microsomes, Liver / Q000378:metabolism; D009022:Morphine Derivatives / Q000008:administration & dosage / Q000378:metabolism* / Q000652:urine; D051381:Rats
D001386:Azides; D005965:Glucuronates; D009022:Morphine Derivatives