Definitive characterization of the para-hydroxyphenyl metabolite of glutethimide in human urine.
The compound, 2-ethyl-2-(4-hydroxyphenyl)-glutarimide was prepared synthetically. Spectral data is presented which identifies this compound to be a metabolite of glutethimide isolated from enzymatically hydrolyzed human urine, following an overdose of the parent drug. New data supporting the structure of a minor metabolite, 2-ethyl-2-(3-methoxy-4-hydroxy)-glutarimide, is considered. Finally, gas chromatographic techniques have been perfected and are presented which yield complete purification of new metabolites of glutethimide.
D002849:Chromatography, Gas; D002855:Chromatography, Thin Layer; D005984:Glutethimide / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000652:urine; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry
D005984:Glutethimide