[Morphological and histochemical characteristics of the reaction of the body to Cl. botulinum toxin administration. III. The cellular reaction of the diaphragmatic nerve nucleus to the administration of Cl. botulinum type B toxin].
On the appearance in the animals (guinea pigs) of paralysis of the limbs and myasthenia after the administration of Cl. botulinum, type B, toxin, there was seen a considerable vascular hyperemia of the spinal cord, and in the neurons of the phrenic nerve nucleus there developed dystrophic-necrotic processes coursing with a marked swelling, hyperchromasia and tigrolysis. As revealed histochemically, at this stage of the botulin intoxication the neurons of the phrenic nerve nucleus displayed metabolic changes expressed in the altered activity of succinic dehydrogenase, acid phosphatase and cholinesterase.
D000135:Acid Phosphatase / Q000378:metabolism; D000818:Animals; D001905:Botulinum Toxins / Q000494:pharmacology*; D001906:Botulism / Q000201:enzymology / Q000473:pathology; D002802:Cholinesterases / Q000378:metabolism; D006168:Guinea Pigs; D009046:Motor Neurons / Q000187:drug effects / Q000201:enzymology; D010791:Phrenic Nerve / Q000187:drug effects* / Q000201:enzymology / Q000473:pathology; D012119:Respiration / Q000187:drug effects; D013116:Spinal Cord / Q000473:pathology; D013385:Succinate Dehydrogenase / Q000378:metabolism; D013997:Time Factors
D013385:Succinate Dehydrogenase; D002802:Cholinesterases; D000135:Acid Phosphatase; D001905:Botulinum Toxins
Morfologicheskaia i gistokhimicheskaia kharakteristika reaktsii organizma na vvedenie toksina C. botulinum. Soobshchenie III. Reaktsiia kletok iadra diafragmal'nogo nerva na vvedenie toksina Cl. botulinum tipa B