Drug-induced adrenaline release and blood glucose in rats: 3-phenyl-5(2-piperidinoethyl)-isoxazole citrate.
The effects of 3-phenyl-5-(2-piperidinoethyl)-isoxazole citrate (31245) on blood glucose level and adrenaline release from the adrenal gland were studied in rats. Elevation of blood glucose was detected in intact and hypophysectomized rats, but not in adrenalectomized or adrenal-demedullated rats after s.c.injection of 31245. Increase of adrenaline release from the left adrenal after administration of 31245 was detected under pentobarbital anesthesia. In splanchnicotomized rats, no increase of adrenaline secretion was observed after administration of this compound. Pretreatment with 31245, 5 mg/kg i.v., prevented about 35% of the adrenaline output caused by electrical stimulation of the splanchnic nerve, though it had no inhibitory effect on adrenaline secretion caused by histamine and bradykinin. From these results, it is concluded that hyperglycemia induced by 31245 is due to hypersecretion of adrenaline from the adrenal glands through excitation of the splanchnic nerves, though its direct action on the gland is an inhibitory effect on adrenaline release.
D000311:Adrenal Glands / Q000502:physiology; D000315:Adrenalectomy; D000632:Aminopyrine / Q000494:pharmacology; D000818:Animals; D001920:Bradykinin / Q000494:pharmacology; D004837:Epinephrine / Q000378:metabolism*; D006632:Histamine / Q000494:pharmacology; D007016:Hypophysectomy; D008297:Male; D010080:Oxazoles / Q000494:pharmacology*; D010653:Phenylbutazone / Q000494:pharmacology; D010880:Piperidines / Q000494:pharmacology*; D051381:Rats; D013153:Splanchnic Nerves / Q000502:physiology
D010080:Oxazoles; D010880:Piperidines; D000632:Aminopyrine; D006632:Histamine; D010653:Phenylbutazone; D001920:Bradykinin; D004837:Epinephrine