Effect of volatile anaesthetics on cell survival as measured by colony forming ability.
Chinese hamster fibroblast cells in stirred suspension cultures were exposed to volatile anaesthetic agents for 3 hr or for 24 hr. Cell viability was measured as colony forming ability and was found to be reduced, in a dose related manner, by halothane, chloroform, methoxyflurane, trichloroetheylene and diethyl ether.
D000777:Anesthetics / Q000494:pharmacology*; D002470:Cell Survival / Q000187:drug effects*; D002478:Cells, Cultured; D002725:Chloroform / Q000494:pharmacology; D002999:Clone Cells / Q000187:drug effects; D003864:Depression, Chemical; D004305:Dose-Response Relationship, Drug; D004986:Ether / Q000494:pharmacology; D005347:Fibroblasts; D006221:Halothane / Q000494:pharmacology; D008733:Methoxyflurane / Q000494:pharmacology; D013997:Time Factors; D014241:Trichloroethylene / Q000494:pharmacology; D014835:Volatilization
D000777:Anesthetics; D004986:Ether; D014241:Trichloroethylene; D008733:Methoxyflurane; D002725:Chloroform; D006221:Halothane