Cardiovascular effects of dopamine in the normal and failing heart of experimental animals.
Dopamine exerts marked positive inotropic effects in the dog with no effect on heart rate. This effect is abolished by propranolol, reduced by reserpine, and unaffected by atropine. Dopamine exhibits similar inotropic activity in the normal guinea pig and in guinea pigs with experimentally induced heart failure. In the isolated perfused hamster heart, dopamine caused marked increases in left ventricular pressure with slight increases in heart rate. However, in the failing heart of the myopathic Syrian hamster, dopamine caused moderate increases in left ventricular pressure with much greater increases in heart rate. The total heart work of the failing heart under the influence of dopamine is significantly higher than that of the normal heart. The energy utilization under this condition is equal in both hearts. Therefore, the calculated efficiency of the failing heart treated with dopamine is much higher than that of the normal heart treated similarly.
D000818:Animals; D001285:Atropine / Q000494:pharmacology; D001794:Blood Pressure / Q000187:drug effects; D006224:Cricetinae; D004285:Dogs; D004298:Dopamine / Q000494:pharmacology / Q000627:therapeutic use*; D018492:Dopamine Antagonists; D005260:Female; D006168:Guinea Pigs; D006333:Heart Failure / Q000188:drug therapy*; D006339:Heart Rate / Q000187:drug effects; D008297:Male; D008996:Monoamine Oxidase Inhibitors; D009200:Myocardial Contraction / Q000187:drug effects; D010293:Pargyline / Q000494:pharmacology; D011433:Propranolol / Q000494:pharmacology; D012110:Reserpine / Q000494:pharmacology
D018492:Dopamine Antagonists; D008996:Monoamine Oxidase Inhibitors; D001285:Atropine; D012110:Reserpine; D010293:Pargyline; D011433:Propranolol; D004298:Dopamine