title: Role of the kidney in development of cystitis and other toxic effects of cyclophosphamide.
abstract: Cystitis caused by excretion of cyclophosphamide (CY) metabolites in the urine was prevented by nephrectomy. There was a concomitant increase of CY lesions in brain, eye, and spleen due to the avoidance of urinary losses. Anuria caused by extra- or intrarenal obstruction, or by prerenal deviation of water, also prevented cystis; these procedures enhanced other CY lesions more than nephrectomy did. The data are interpreted to indicate significant production of active CY metabolites by the kidneys, a production which is eliminated by nephrectomy but not by other procedures.
mesh_terms: D000315:Adrenalectomy; D000818:Animals; D001002:Anuria; D003520:Cyclophosphamide / Q000378:metabolism / Q000633:toxicity*; D003556:Cystitis / Q000139:chemically induced* / Q000517:prevention & control; D007668:Kidney / Q000378:metabolism*; D008026:Ligation; D008297:Male; D009392:Nephrectomy; D051381:Rats; D014513:Ureter / Q000601:surgery; D014521:Urethra / Q000601:surgery
chemical_list: D003520:Cyclophosphamide