Protein synthesis in human gastric mucosa: effects of pentagastrin, secretin, and 13-nle-motilin.
This study in man (n = 35) deals with the effects of in vivo administration of pentagastrin, synthetic secretin, and 13-norleucine-motilin (13-nle-motillin), respectively, on the in vitro incorporation of 14C-leucine into gastric mucosal protein. From the results presented it may be concluded that pentagastrin has a trophic influence on gastric mucosa in man, too, while protein synthesis in human duodenal mucosa remains unaltered. As the incorporatin of 14C-leucine into gastric mucosal protein is inhibited both by secretion and 13-nle-motiln, it may be hypothesised that secretin and motilin act as functional antagonists of gastrin in the regulation of human gastric mucosal protein synthesis.
D000328:Adult; D004386:Duodenum / Q000378:metabolism; D005260:Female; D005753:Gastric Mucosa / Q000187:drug effects* / Q000378:metabolism; D005768:Gastrointestinal Hormones / Q000494:pharmacology*; D005769:Gastrointestinal Motility / Q000187:drug effects; D006801:Humans; D007413:Intestinal Mucosa / Q000378:metabolism; D008297:Male; D009646:Norleucine / Q000494:pharmacology; D010418:Pentagastrin / Q000494:pharmacology; D014176:Protein Biosynthesis; D012633:Secretin / Q000494:pharmacology
D005768:Gastrointestinal Hormones; D012633:Secretin; D009646:Norleucine; D010418:Pentagastrin