title: [Chemotherapy of generalized forms of lymphogranulomatosis with vinblastine and vincristine].
abstract: An experience with vinblastine and vincristine, used separately and together for treatment of 69 patients with lymphogranulomatosis, stage III and IV, enabled the author to draw the conclusion as to the rationality of the combination therapy with these cytostatics of nearly similar chemical structure and actively influencing the lymphogranulomatous tissue. Of special interest is the efficacy of using vinblastine in combination with vincristine in patients showing lymphogranulomatous lesions of the lung, especially in case of destructive changes, in comparatively low toxic affects of a combination of these substances.
mesh_terms: D000328:Adult; D000368:Aged; D004359:Drug Therapy, Combination; D005260:Female; D006689:Hodgkin Disease / Q000188:drug therapy*; D006801:Humans; D008297:Male; D008875:Middle Aged; D012075:Remission, Spontaneous; D013997:Time Factors; D014747:Vinblastine / Q000008:administration & dosage* / Q000009:adverse effects / Q000627:therapeutic use; D014750:Vincristine / Q000008:administration & dosage* / Q000009:adverse effects / Q000627:therapeutic use
chemical_list: D014750:Vincristine; D014747:Vinblastine
vernacular_title: Khimioterapiia vinblastinom i vinkristinom generalizovannykh form limfogranulematoza