[Ultrastructural and functional expression of the hepatocyte genome in conditions of prolonged suppression by cycloheximide of protein synthesis. IV].
RNA synthesis was intensified in isolated nuclei of the rat liver an hour after the animal treatment with cycloheximide (CHI). Incubation of the nuclei with a cytoplasmic fraction 160000 g obtained from normal rats decreases RNA synthesis, and that obtained from CHI-treated animals-increases it. Mechanisms of this effects are discussed.
D000818:Animals; D002467:Cell Nucleus / Q000378:metabolism; D003593:Cytoplasm; D008099:Liver / Q000187:drug effects / Q000378:metabolism*; D008297:Male; D014176:Protein Biosynthesis; D012313:RNA / Q000096:biosynthesis*; D051381:Rats; D013997:Time Factors; D014020:Tissue Extracts / Q000494:pharmacology
D014020:Tissue Extracts; D012313:RNA
Issledovanie ul'trastrukturnogo i funktsional'nogo vyrazheniia genoma gepatotsitiv v usloviiakh prodolzhitel'nogo ugneteniia biosinteza belka tisklogeksimidom