Modification of the contractile responses of rabbit mammary strips to oxytocin by prostaglandin E1.
PGE1 administration to isolated strips from pregnant and lactating rabbit mammary gland resulted in different effects on oxytocin-induced contractions. In strips from pregnant animals, oxytocin action was enhanced; in those from lactating animals, it was reduced and threshold doses for oxytocin were markedly higher.
D000818:Animals; D004305:Dose-Response Relationship, Drug; D004347:Drug Interactions; D005260:Female; D066298:In Vitro Techniques; D007774:Lactation; D008321:Mammary Glands, Animal / Q000187:drug effects* / Q000502:physiology; D009119:Muscle Contraction / Q000187:drug effects; D010121:Oxytocin / Q000494:pharmacology*; D011247:Pregnancy; D011458:Prostaglandins E / Q000494:pharmacology*; D011817:Rabbits
D011458:Prostaglandins E; D010121:Oxytocin