title: Gastric acid secretion in a teleostean fish: a method for the continous collection of gastric effluence from a swimming fish and its response to histamine and pentagastrin.
abstract: Gastric acid secretion has been measured in the codfish (Gadus morhua) equipped with a catheter draining the stomach, by titrating the water swallowed by the fish. Unstimulated acid secretion was found to be very low; in most fishes not exceeding 8 mumol H+/kg h. Intramuscular injection of histamine evokes a dose-dependent secretion of gastric acid, with a maximum acid output of 300 mumul/kg h occurring with 10 mg/kg histamine dihydrochloride. No acid response was obtained with pentagastrin.
mesh_terms: D000818:Animals; D002404:Catheterization / Q000662:veterinary; D005260:Female; D005399:Fishes / Q000502:physiology*; D005745:Gastric Acidity Determination / Q000379:methods; D005750:Gastric Juice / Q000378:metabolism*; D006632:Histamine / Q000494:pharmacology*; D008297:Male; D010418:Pentagastrin / Q000494:pharmacology*; D012636:Secretory Rate / Q000187:drug effects
chemical_list: D006632:Histamine; D010418:Pentagastrin