Pharmacological effects of urotensins. III. Fate or Urotensin I in different vascular beds and in blood of the rat.
The rates of disappearance of urotensin I, a peptide with a prolonged vasodepressor action, was studied in perfused isolated organs of the rat and in rat blood in vitro. The rates ranged from 29.9+/-3.2% in the perfused hind limb to 55.1 +/- 7.2% in the lungs. Urotensin I activity disappeared slowly during incubation with rat blood, the "half-life" being about 4 min. The fast removal or urotensin I by the organs contrasts with its long duration of action.
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D003864:Depression, Chemical; D006207:Half-Life; D008297:Male; D010455:Peptides / Q000097:blood / Q000378:metabolism* / Q000494:pharmacology; D010477:Perfusion; D051381:Rats; D013997:Time Factors
D010455:Peptides