Effect of ceruloplasmin on AoPR8 influenza virus infection in embryonate eggs and mice.
Inoculation to embryonate hen eggs and mice of AoPR8 influenza virus pre-incubated with ceruloplasmin (10(-7)-10(-6) M) results in a statistically significant decrease in the hemagglutinating titer of the virus, without changes in infectivity. This effect is ascribed to formation of a virus-ceruloplasmin complex, which probably interferes with both virus penetration and release of newly formed virus from the cell.
D000818:Animals; D002570:Ceruloplasmin / Q000494:pharmacology*; D002642:Chick Embryo; D006389:Hemagglutinins, Viral / Q000032:analysis; D051379:Mice; D009975:Orthomyxoviridae; D009976:Orthomyxoviridae Infections; D014779:Virus Replication / Q000187:drug effects
D006389:Hemagglutinins, Viral; D002570:Ceruloplasmin