Clinico-biochemical, immunological, and morphological assessment of myocardial inflammatory reactions in myocardial necroses.
In 328 patients with myocardial infarction, changes were followed occurring in the levels of haptoglobin (Hp) and chloride-soluble mucoprotein (CMP), heterogeneity of mucoprotein, and titres of anticardial antibodies. From the 2nd-3rd days after infarction, the levels of Hp, CMP, and 3rd and 4th mucoprotein fractions increased and remained elevated for 4 weeks; then the levels gradually sank, and normalized in the 7th-8th weeks after infarction. The anticardial antibody titres remained high from the 3rd to the 6th weeks. In 37 patients who died, the clinico-biochemical, immunobiological, and morphological findings were compared. It was found that assessments of the Hp and CMP levels as well as of mucoprotein heterogeneity make it possible to appraise the intensity of inflammatory reaction in myocardial necroses and thus facilitate the choice of differentiated antiinflammatory treatment of patients with myocardial infarction.
D000906:Antibodies / Q000032:analysis; D006023:Glycoproteins / Q000097:blood; D006242:Haptoglobins / Q000097:blood; D006801:Humans; D009088:Mucoproteins / Q000097:blood; D009203:Myocardial Infarction / Q000097:blood / Q000276:immunology / Q000473:pathology*; D009206:Myocardium / Q000276:immunology / Q000473:pathology*; D009336:Necrosis
D000906:Antibodies; D006023:Glycoproteins; D006242:Haptoglobins; D009088:Mucoproteins