[Change in monoamine content and monoamine oxidase activity in brain structures during experimental allergic encephalomyelitis].
The serotonin, noradrenaline, adrenaline concentration in the blood, cerebrospinal fluid and some brain structures, and tissue monoaminoxidase activity (MAO) were investigated in dogs during experimental allergic encephalomyelitis. During the perparalytic period there was a tendency to reduction of the serotonin concentration and to the elevation of the catecholamine content. The stage of clinical manifestation of encephalomyelitis was accompanied by reduction of the serotonin level in the white matter of the cerebral hemispheres, and by genralized inhibition of the adrenergic structures. In this case the MAO activity displayed no significant change; this permitted to consider the disturbance of the monoamine synthesis as a result of immune aggression, as a possible cause of inhibition of the monoaminergic system.
D000818:Animals; D001679:Biogenic Amines / Q000097:blood / Q000134:cerebrospinal fluid / Q000378:metabolism*; D001921:Brain / Q000201:enzymology; D002540:Cerebral Cortex / Q000378:metabolism; D002746:Chlorpromazine / Q000494:pharmacology; D004285:Dogs; D004681:Encephalomyelitis, Autoimmune, Experimental / Q000097:blood / Q000134:cerebrospinal fluid / Q000378:metabolism*; D004837:Epinephrine / Q000097:blood / Q000134:cerebrospinal fluid / Q000378:metabolism; D007032:Hypothalamus, Anterior / Q000378:metabolism; D007034:Hypothalamus, Posterior / Q000378:metabolism; D008297:Male; D008995:Monoamine Oxidase / Q000378:metabolism*; D009638:Norepinephrine / Q000097:blood / Q000134:cerebrospinal fluid / Q000378:metabolism; D011619:Psychotropic Drugs / Q000494:pharmacology*; D012701:Serotonin / Q000097:blood / Q000134:cerebrospinal fluid / Q000378:metabolism
D001679:Biogenic Amines; D011619:Psychotropic Drugs; D012701:Serotonin; D008995:Monoamine Oxidase; D002746:Chlorpromazine; D009638:Norepinephrine; D004837:Epinephrine
Izmenenie soderzhaniia monoaminov i aktivnosti monoaminoksidazy v strukturakh mozga pri éksperimental'nom allergicheskom éntsefalomielite