[Effect of thyroxine and hydrocortisone on the content of retinol and retinyl palmitate in liver tissue, kidney and blood of rats, loaded with high doses of retinyl acetate].
Administration of hight doses of retinyl acetate into rats caused an increase in content of retinol in liver tissue and kidney and retinyl palmitate in liver tissue, kidney and blood. The simultaneous administration of thyroxine decreased the accumulation of retinol and retinyl palmitate in liver tissue. At the same time, in kidney content of retinol was increased but content of retinol and retinyl palmitate in blood and retinyl palmitate in kidney did not differ from the values estimated in the control group. The simultaneous administration of retinyl acetate and hydrocortisone decreased the accumulation of retinol and retinyl palmitate in liver tissue, increased the content of vitamin A in blood and did not influence its content in kidney.
D000818:Animals; D006854:Hydrocortisone / Q000494:pharmacology*; D007668:Kidney / Q000187:drug effects / Q000378:metabolism*; D008099:Liver / Q000187:drug effects / Q000378:metabolism*; D009928:Organ Specificity; D010169:Palmitic Acids / Q000097:blood / Q000378:metabolism; D051381:Rats; D013974:Thyroxine / Q000494:pharmacology*; D014801:Vitamin A / Q000031:analogs & derivatives* / Q000097:blood / Q000378:metabolism*
D010169:Palmitic Acids; D014801:Vitamin A; D013974:Thyroxine; D006854:Hydrocortisone
Vliianie tiroksina i gidrokortizona na coderzhania retinola i retinilpal'mitata v peeheni, pochkakh i krovi krys, poluchayshikh vysokie dozy retinilatsetatata.