[The morphologic basis for the mechanism of increased serum acid phosphatase activity in patients with viral hepatitis].
The activity of acid phosphotase in the blood serum and punctates of the liver was studied in 49 patients with acute cyclic form of viral hepatitis of slight and medium-grave course with the use of histological and histochemical methods. The degree of manifestation of necrotic changes in the punctate tissue was determined with the help of the stereometric method. As a result of the studies conducted, it was established that the degree of hyperfermentemia was the highest at the period when the disease was in full swing, and that it did not depend on the form of its course and extent of necrotic changes observed in the liver punctates. The authors consider a morphological evidence of high activity of acid phosphotase in the blood serum aggregations of large hepatocytes, cytoplasm of which was loaded with mature lipofuscin, the topographic identity of the latter with acid phosphotase at present being proved.
D000135:Acid Phosphatase / Q000097:blood*; D000293:Adolescent; D006506:Hepatitis A / Q000097:blood / Q000201:enzymology*; D006651:Histocytochemistry; D006801:Humans; D008062:Lipofuscin / Q000378:metabolism*; D008099:Liver / Q000201:enzymology*; D008297:Male; D010860:Pigments, Biological / Q000378:metabolism*
D008062:Lipofuscin; D010860:Pigments, Biological; D000135:Acid Phosphatase
Morfologicheskoe obosnovanie mekhanizma povysheniia aktivnosti kisloĭ fosfatazy v syvorotke krovi bol'nykh virusnym gepatitom