title: Inner ear damage and hearing loss after exposure to tones of high intensity.
abstract: Experimental animals (cats) were exposed to tones of 125, 1000, 2000, and 4000 Hz at sound pressure levels in the range 120 to 157.5 dB, and for durations of one hour (1000, 2000, 4000 Hz) or four hours (125 Hz). Pure tone audiograms were obtained for each animal before and after exposure. Post-exposure tests were continued until complete recovery of hearing had occurred or until a stable permanent threshold shift had been measured. Cochleas of animals were examined by phase-contrast microscopy; condition of all hair cells was recorded. Extent of inner-ear damage and range of frequencies for which hearing loss occurred increased as exposure tone was decreased in frequency. For example, exposure to 4000 Hz produced damage in a restricted region of the cochlea and hearing loss for a relatively narrow range of frequencies; exposure to 125 Hz produced wide-spread inner ear damage and hearing loss throughout the frequency range 125 to 6000 Hz.
mesh_terms: D000161:Acoustic Stimulation; D000818:Animals; D001309:Auditory Threshold; D002415:Cats; D007758:Ear, Inner / Q000502:physiology* / Q000503:physiopathology; D006311:Hearing Disorders / Q000503:physiopathology*; D006317:Hearing Loss, Noise-Induced / Q000503:physiopathology*; D006320:Hearing Tests