title: Tests for association of gene frequencies at several loci in random mating diploid populations.
abstract: Methods are outlined for analyzing data on genotype frequencies at several codominant loci in random mating diploid populations. Maximum likelihood (ML) methods are given for estimating chromosomal frequencies. Using these, a succession of models of assumed independence of gene frequency are fitted. These are based on those used in multi-dimensional contigency tables, and tests for association (linkage disequilibrium), made using likelihood ratios. The methods are illustrated with an example.
mesh_terms: D004171:Diploidy; D005787:Gene Frequency; D008040:Genetic Linkage; D008954:Models, Biological