Collateral vessel formation: isolation of a transferable factor promoting a vascular response.
Collateral vessel formation to the kidney was induced by renal artery stenosis or embolization in six dogs. Extracts from control and collateral-forming kidneys were assessed for their ability to promote a vascular response in the hamster cheekpouch. The highly significant response evoked by particulate and soluble fractions of cytoplasm from collateral-forming kidneys suggests a humoral element in collateral vessel formation.
D000818:Animals; D001681:Biological Assay; D002610:Cheek / Q000098:blood supply; D003097:Collateral Circulation; D006224:Cricetinae; D004285:Dogs; D007511:Ischemia / Q000503:physiopathology; D007668:Kidney / Q000098:blood supply* / Q000378:metabolism; D012078:Renal Artery Obstruction / Q000503:physiopathology