[Lowering of serum bilirubin following experimental ligation of the bile duct. Affinity-chromatography binding of bilirubin to albumin conjugated with agarose].
Principle and procedure of a new method in the treatment of experimental hyperbilirubinemia for removing protein-bound, not dialyzable substances from blood by extracorporeal hemoperfusion are described. In six out of eight experiments a decrease of serum bilirubin levels between 11 and 36% has been accomplished. Changes in hemograms are reported and correlations between serum bilirubin value, amount bilirubin bound by the agarose beads and bilirubin clearance rate are discussed.
D000818:Animals; D001652:Bile Ducts / Q000601:surgery; D001663:Bilirubin / Q000097:blood*; D002846:Chromatography, Affinity; D006932:Hyperbilirubinemia / Q000628:therapy*; D008026:Ligation; D008722:Methods; D011134:Polysaccharides / Q000378:metabolism*; D011485:Protein Binding; D011817:Rabbits; D006435:Renal Dialysis; D012685:Sepharose / Q000378:metabolism*; D012709:Serum Albumin / Q000378:metabolism*
D011134:Polysaccharides; D012709:Serum Albumin; D012685:Sepharose; D001663:Bilirubin
Senkung des Serumbilirubinspiegels durch Hämoperfusion nach experimenteller Gallengangsunterbindung. Affinitätschromatographische Bindung von Bilirubin an Albumin konjugiert mit Agarose