title: Molecular basis of prostaglandin potency. II. Proton NMR studies of the conformation of prostaglandin F2alpha.
abstract: The proton nmr of PGF2alpha (dissolved in aqueous tBuOH) in the presence of PrC13 and limited amounts of base shows LIS shifts for the terminal methyl indicating an average effective chain length (C-1 to C-20) like that of octanoic acid, further evidence that the alpha and omega carbons of prostaglandins are closer in space than would be expected based on a random distribution of confermers with alternate zig-zag sections of  hydrocarbon chains. Assessing the exact nature of the sidechain alignment will require further experiments.
mesh_terms: D055598:Chemical Phenomena; D002621:Chemistry; D009682:Magnetic Resonance Spectroscopy; D008968:Molecular Conformation; D011460:Prostaglandins F
chemical_list: D011460:Prostaglandins F