title: [Study of the pathogenesis of toxoplasmosis by means of tagged atoms].
abstract: The authors' investigations showed a principal possibility of labeling toxoplasma with radioactive isotopes on condition of the administration of the latter in vivo into the donor animals infected with toxoplasmosis. The labeled atom method could be used for studying the pathogenesis of toxoplasmosis in the experimental animals, particularly at the early periods of the infectious process. The use of the labeled atom method permitted not only to confirm the results obtained by parasitological and pathomorphological studies, but also to reveal the fact of a primary parasitemia, later confirmed by biopsy. In combination with other methods of study the labeled atom method can be used for studying various aspects of the problem of toxoplasmosis, particularly of the mechanisms of transmission of the infection.
mesh_terms: D000818:Animals; D004307:Dose-Response Relationship, Radiation; D008722:Methods; D051379:Mice; D010758:Phosphorus / Q000008:administration & dosage; D010761:Phosphorus Radioisotopes; D011830:Radiation Effects; D011849:Radioactive Tracers; D011851:Radioactivity; D011868:Radioisotopes; D011874:Radiometry; D013997:Time Factors; D014122:Toxoplasma / Q000302:isolation & purification / Q000472:pathogenicity; D014124:Toxoplasmosis, Animal / Q000209:etiology*; D014774:Virulence / Q000528:radiation effects
chemical_list: D010761:Phosphorus Radioisotopes; D011849:Radioactive Tracers; D011868:Radioisotopes; D010758:Phosphorus
vernacular_title: Ob izuchenii patogeneza toksoplazmoza metodom mechenykh atomov