[Cytogenetic effect of mitomycin C and cytosine arabinoside on mice of different genotypes].
Cytogenetic effect of mitomycin C (MC) and cytosine arabinoside (CA) on bone marrow cells of male mice of the strains 101/HY, C57BL/6Y C,3H/SnY and of the (C3HX101) F1 hybrids was studied. The frequencies of cells with chromosome aberrations after the treatment with MC at a 5 mg/kg dose were 54,4%; 41,8%; 40,4% and 26,8% in 101H, B6, C3H/Sn mice and in the F1 hybrids (C3HX101) respectively. The frequencies of cells with chromosome aberrations after the treatment with CA at a 500 mg/kg dose were 25,2%; 17,8%; 10,8% and the 101/H, B6, C3H/Sn mice and in the F1 hybrids (C3HX101) respectively. Both mutagens induced the greatest number of chromosome aberrations in the 101/H strain and the smallest number in the F1 hybrid (C3HX101). A positive correlation was established between the levels of induced and spontaneous chromosome lesions.
D000818:Animals; D001853:Bone Marrow / Q000187:drug effects*; D001854:Bone Marrow Cells; D002869:Chromosome Aberrations; D003561:Cytarabine / Q000633:toxicity*; D004305:Dose-Response Relationship, Drug; D005838:Genotype; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D008937:Mitomycins / Q000633:toxicity*; D013997:Time Factors
D008937:Mitomycins; D003561:Cytarabine
Tsitogeneticheskiĭ éffekt mitomitsina C i tsitozin-arabinozida u mysheĭ raznogo genotipa