title: The motor-stimulating effect of natural motilin on the lower esophageal sphincter fundus, antrum and duodenum in dogs.
abstract: Natural motilin was investigated for its effect on gastrointestinal motor activity in anesthetized dogs. In doses starting from 10 ng/kg as single injection and 100 ng/kg-h as intravenous infusion, motilin induced phasic pressure changes in the lower esophageal sphincter (LES) and in the lumen of the fundus, antrum, and duodenum. Tachyphylaxis was seen in 6 out of 10 dogs. Motilin had no effect on isolated muscle strip preparations of the LES, fundus, antrum, and duodenum in this species.
mesh_terms: D000818:Animals; D004285:Dogs; D004386:Duodenum / Q000187:drug effects*; D004943:Esophagogastric Junction / Q000187:drug effects*; D005260:Female; D005768:Gastrointestinal Hormones / Q000494:pharmacology*; D005769:Gastrointestinal Motility / Q000187:drug effects*; D008297:Male; D009646:Norleucine / Q000031:analogs & derivatives / Q000494:pharmacology; D010455:Peptides / Q000494:pharmacology*; D011706:Pyloric Antrum / Q000187:drug effects; D013268:Stimulation, Chemical; D013270:Stomach / Q000187:drug effects*; D013618:Tachyphylaxis
chemical_list: D005768:Gastrointestinal Hormones; D010455:Peptides; D009646:Norleucine