Dexamethasone effect on blood-brain barrier damage caused by acute hypertension in x-irradiated rabbits.
Unilateral X-ray exposure of brain increases the vulnerability of cerebral vessels to acute hypertension in the brain hemisphere exposed to radiation. A preventive effect of dexamethasone was observed when treatment with the drug was started before irradiation; but also when the drug was given 24 h before acute hypertension was induced, 1 week after irradiation.
D000818:Animals; D001812:Blood-Brain Barrier / Q000528:radiation effects*; D003907:Dexamethasone / Q000627:therapeutic use*; D006973:Hypertension / Q000188:drug therapy / Q000209:etiology*; D011817:Rabbits; D011830:Radiation Effects
D003907:Dexamethasone