Comparative studies on the effect of lithium and haloperidol on learning and memory.
A comparative study of the effect of lithium and haloperidol on the processes of learning and memory is carried out in experiments for training albino rats in a maze. Haloperidol introduced intraperitoneally 1 h before learning in a dose of 0.2 mg/kg deteriorates the learning and long-term memory, while a dose of 2 mg/kg makes these processes impossible. Introduced immediately after learning, haloperidol shows a tendency towards deterioration in the phase of memory consolidation. When administered 1 h before the long-term memory test, haloperidol inhibits reproduction. Lithium chloride administered in a single dose of 200 or 300 mg/kg before and after learning, has no pronounced effect. A tendency towards impairment of learning and memory is manifested only upon administration of doses of 200 mg/kg for 8 days in succession. The differences in the effects of lithium and haloperidol on learning and memory do not support the assumption that their similar effect on the cAMP system (inhibition of the adenylate cyclase in the brain) is essential for the mechanism of their effect on the central nervous system.
D000818:Animals; D001362:Avoidance Learning / Q000187:drug effects; D004558:Electric Stimulation; D006220:Haloperidol / Q000494:pharmacology*; D007858:Learning / Q000187:drug effects*; D008094:Lithium / Q000494:pharmacology*; D008297:Male; D008568:Memory / Q000187:drug effects*; D051381:Rats; D013997:Time Factors
D008094:Lithium; D006220:Haloperidol