Role of the kidney in development of cystitis and other toxic effects of cyclophosphamide.
Cystitis caused by excretion of cyclophosphamide (CY) metabolites in the urine was prevented by nephrectomy. There was a concomitant increase of CY lesions in brain, eye, and spleen due to the avoidance of urinary losses. Anuria caused by extra- or intrarenal obstruction, or by prerenal deviation of water, also prevented cystis; these procedures enhanced other CY lesions more than nephrectomy did. The data are interpreted to indicate significant production of active CY metabolites by the kidneys, a production which is eliminated by nephrectomy but not by other procedures.
D000315:Adrenalectomy; D000818:Animals; D001002:Anuria; D003520:Cyclophosphamide / Q000378:metabolism / Q000633:toxicity*; D003556:Cystitis / Q000139:chemically induced* / Q000517:prevention & control; D007668:Kidney / Q000378:metabolism*; D008026:Ligation; D008297:Male; D009392:Nephrectomy; D051381:Rats; D014513:Ureter / Q000601:surgery; D014521:Urethra / Q000601:surgery
D003520:Cyclophosphamide