[Effect of angiotensin II on the pattern of plasma free fatty acids in 2 hypertension models in rabbits].
The effect of exogenous angiotensin II on the spectrum of nonesterified fatty acids (NEFA) in blood plasma was studied by gas-chromatographic analysis in 10 normotonic rabbits, 12 rabbits with experimental hypertension induced by sinoaortic denervation, and in 14 rabbits with experimental renal hypertension. One minute after injection of angiotensin II, the following changes were found in the spectrum of NEFA: increase in the fraction of saturated, and decrease in the fraction of unsaturated NEFA;the intensity of these changes was higher in the animals with renal hypertension than in those with hypertension induced by sinoaortic denervation, and lowest in the normotonic rabbits. Thirty to sixty minutes after injection the above changes further gained in intensity in both models of hypertension, whereas in normotonic rabbits the changes rather receded. A growing dominance of palmitic acid, persistent elevation of stearic acid, decreases in the levels of monoenolic oleic and palmitoleic acids as well as of polyenolic fatty acids were observed.
D000804:Angiotensin II / Q000494:pharmacology*; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D004195:Disease Models, Animal; D005230:Fatty Acids, Nonesterified / Q000097:blood*; D006973:Hypertension / Q000097:blood*; D006977:Hypertension, Renal / Q000097:blood; D008297:Male; D011817:Rabbits; D013997:Time Factors
D005230:Fatty Acids, Nonesterified; D000804:Angiotensin II
Der Einfluss von Angiotensin II auf das Muster der freien Fettsäuren im Blutplasma bei zwei verschiedenen Hypertoniemodellen am Kaninchen