title: Delayed excretion of conjugated sulphamethoxazole in uraemia.
abstract: Persistence in the serum of free and conjugated sulphamethoxazole was estimated in five normal controls and in nine uraemic patients with creatinine clearances under 20 ml/min, after a single one-gram dose of the drug. In the uraemic group delayed disappearance of the free drug was found. Conjugated sulphamethoxazole retention was 62.44% at 24 hr after the oral load, and 13.7% 19 days later. Risk of accumulation of sulphamethoxazole in uraemia is emphasised. Re-evaluation of the use of this drug in patients with impaired renal function is recommended.
mesh_terms: D006801:Humans; D007668:Kidney / Q000378:metabolism*; D013420:Sulfamethoxazole / Q000378:metabolism*; D014511:Uremia / Q000378:metabolism*
chemical_list: D013420:Sulfamethoxazole