[Hypoparathyroidismus following L-asparaginase and vaccinia virus infection. Effect of hypocalcemia on phagocytosis and the function of lymphocytes].
Rabbits, treated with injections of 4000 IU of L-Asparaginase, develop the clinical and chemical signs of hypoparathyroidism. A simultaneous vaccination with vaccinia virus (strain "Elstree") markedly increase the tetanic symptoms ("conditioned deficiency"). L-Asparaginase may influence the cellular immunity by hypocalcemia. Two mechanisms are discussed: 1. the suppression of the phagocytosis, recognizable by the absence of signs for vaccinal allergy by deficiency of macrophages in the intradermal test with inactivated small-pox vaccine. 2. the inhibition of the PHA-induced lymphocyte transformation caused by deficiency of  calcium ions.
D000469:Alkaline Phosphatase / Q000097:blood; D000818:Animals; D001215:Asparaginase / Q000009:adverse effects* / Q000494:pharmacology; D001798:Blood Proteins / Q000378:metabolism; D004195:Disease Models, Animal; D005260:Female; D006996:Hypocalcemia / Q000503:physiopathology*; D007011:Hypoparathyroidism / Q000139:chemically induced*; D007111:Immunity, Cellular / Q000187:drug effects; D008214:Lymphocytes / Q000187:drug effects / Q000276:immunology; D008264:Macrophages / Q000502:physiology; D008274:Magnesium / Q000097:blood; D008297:Male; D010587:Phagocytosis / Q000187:drug effects; D010710:Phosphates / Q000097:blood; D011188:Potassium / Q000097:blood; D011817:Rabbits; D012882:Skin Tests; D014616:Vaccinia virus
D001798:Blood Proteins; D010710:Phosphates; D000469:Alkaline Phosphatase; D001215:Asparaginase; D008274:Magnesium; D011188:Potassium
Hypoparathyreoidismus durch L-Asparaginase und Vaccinia-Virusinfektion. Einfluss der Hypocalcämie auf die Phagozytose und die Lymphozytensunktion