title: [Behavior of alkaline phosphatase in serum during pregnancy. I. Normal pregnancy].
abstract: On 120 patients, during normal pregnancy, from the 17th to the 42nd week of pregnancy, 372 heat labile alkaline phosphatase estimations were carried out by means of the 4-nitrophenol method. In addition to that, after incubation of sera at 65 degrees C for 30 minutes, the activity of the heat stable placental isoenzyme was checked. With progressing pregnancy, the heat stable fraction rises significantly and the heat labile fraction of total alkaline phosphatase increases slightly. There is a correlation between the readings of the two fractions. In 169 cases, the total urinary oestrogen output correlates also with the heat stable alkaline phosphatase.
mesh_terms: D000469:Alkaline Phosphatase / Q000097:blood*; D005260:Female; D005865:Gestational Age; D006801:Humans; D007527:Isoenzymes / Q000097:blood; D010920:Placenta / Q000201:enzymology; D010922:Placenta Diseases / Q000201:enzymology; D011247:Pregnancy; D012044:Regression Analysis; D013696:Temperature
chemical_list: D007527:Isoenzymes; D000469:Alkaline Phosphatase
vernacular_title: Zum Verhalten der alkalischen Phosphatase im Serum während der Gravität. I. Normale Schwangerschaft