Effects of pretreatment with anti-inflammatory drugs on ozone-induced lung damage in rats.
The effects of pretreatment with acetylsalicylic acid (aspirin), hydrocortisone, indomethacin, and heparin administered ip against the pulmonary edema produced by O3-exposure (4 ppm for 4 hr) were studied in rats. These anti-inflammatory drugs were found to alter the injurious effect of O3 on lung differently. First, aspirin at the high dose (125 mg/kg) accentuated O3-induced lung injury, and had no effect at the low dose (10 mg/kg); second, hydrocortisone (50 mg/kg) failed to have any effect; third, indomethacin at a high dose (20 mg/kg) offered a significant degree of protection, but had no effect at the low dose (2.5 mg/kg); and fourth, heparin (1000 units/kg) also offered a significant degree of protection against the lung damage normally induced by O3-exposure. Several mechanisms for the favorable and unfavorable interactions of anti-inflammatory drugs with O3-exposure are discussed.
D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology / Q000627:therapeutic use*; D001241:Aspirin / Q000627:therapeutic use; D004305:Dose-Response Relationship, Drug; D004357:Drug Synergism; D006493:Heparin / Q000627:therapeutic use; D006854:Hydrocortisone / Q000627:therapeutic use; D007213:Indomethacin / Q000627:therapeutic use; D008297:Male; D010126:Ozone / Q000633:toxicity*; D011453:Prostaglandins / Q000096:biosynthesis; D011654:Pulmonary Edema / Q000139:chemically induced* / Q000378:metabolism / Q000517:prevention & control; D051381:Rats
D000893:Anti-Inflammatory Agents; D011453:Prostaglandins; D010126:Ozone; D006493:Heparin; D001241:Aspirin; D006854:Hydrocortisone; D007213:Indomethacin