Urine concentration and dilution: effect on red cell survival.
Survival time of 51Cr-labeled red cells was determined in dogs subjected to water restriction excreting concentrated urine and again following a 6-week period of ad lib. water intake. During water restriction, RBC survival was reduced to one-seventh of normal. In rats with untreated diabetes insipidus, 51Cr RBC survival was reduced 30% as compared to the pitressin-treated state. It appears that RBC survival may be influenced by osmotic stress associated with the state of urine concentration and dilution.
D000818:Animals; D003681:Dehydration; D003919:Diabetes Insipidus / Q000503:physiopathology / Q000652:urine*; D004285:Dogs; D004905:Erythrocyte Aging; D006207:Half-Life; D007671:Kidney Concentrating Ability; D051381:Rats; D014868:Water Deprivation