[An increase in hypothalamic sensitivity to the inhibiting effects of estrogens caused by use of L-DOPA, diphenine, epithalamin and phenformin in old rats].
Daily treatment of hemicastrated young rats with 0.57 mug of stilbestrol inhibited compensatory ovarian hypertrophy (COH) by 48% in the 3-month animals and by 3% only in the 18-month animals. Administration of L-DOPA, dilantin, epithalamin or phenoformin with the same dose of estrogen to old rats suppressed the COH by 65-98%. L-DOPA and epithalamin were effective when administered into the 3rd cerebral ventricle. A functional nature of the age changes in the hypothalamic sensitivity to the estrogen action is suggested.
D000818:Animals; D004054:Diethylstilbestrol / Q000494:pharmacology*; D004357:Drug Synergism; D005260:Female; D007031:Hypothalamus / Q000187:drug effects*; D007980:Levodopa / Q000494:pharmacology; D010629:Phenformin / Q000494:pharmacology; D010870:Pineal Gland; D051381:Rats; D012110:Reserpine / Q000494:pharmacology; D014020:Tissue Extracts / Q000494:pharmacology
D014020:Tissue Extracts; D007980:Levodopa; D004054:Diethylstilbestrol; D012110:Reserpine; D010629:Phenformin
Povyshenie chuvstvitel'nosti gipotalamusa k ingibiruiushchemu deĭstviiu éstrogenov, vyzvannoe primeneniem L-DOFA, difenina, épitalamina i fenformina u starykh krys