[Analysis by means of pancreatozymin of the degree of parallelism of secretion of pancreatic enzymes in healthy persons and patients with chronic pancreatitis].
In 14 normal individuals and in 28 patients with chronic recurrent pancreatitis the total secretion of amylase, lipase and trypsin, as well as the proportions of these enzymes in 20 minute portions of the duodenal contents under basal conditions and after an intravenous injection of 1.5 Un/kg of the "Boots" pancreozymin were studied. A definite disproportion in the stimulated secretion of pancreatic enzymes with a higher amylase/lipase ratio and a lower lipase/trypsin ratio was found to occur as a physiological phenomenon, the degree of this disproportionality, however, being substantially greater in patients with chronic pancreatitis than in healthy persons. An inference is drawn that, along with an investigation into the overall amount of enzymes secreted secondary to pancreozymin stimulation, of importance is not so much the very fact of divulging the non-proportionality of the stimulated pancreatic enzymes secretion, but rather the analysis of the nature and the degree of this disproportionality. This is essential, in particular, when estimating the effect of various nutritional patterns on the external secretion of the pancreas.
D000681:Amylases / Q000378:metabolism; D002766:Cholecystokinin / Q000494:pharmacology; D002908:Chronic Disease; D006801:Humans; D008049:Lipase / Q000378:metabolism; D010179:Pancreas / Q000187:drug effects / Q000201:enzymology*; D010195:Pancreatitis / Q000201:enzymology*; D014357:Trypsin / Q000378:metabolism
D002766:Cholecystokinin; D008049:Lipase; D000681:Amylases; D014357:Trypsin
Analiz s pomoshch'iu pankreozimina stepeni parallelizma vydeleniia pankreaticheskikh fermentov u zdorovykh liudeĭ i bol'nykh khronicheskim pankreatitom