title: Suppressive effect of cyproheptadine on L-DOPA-induced growth hormone release in man.
abstract: In order to elucidate the relationship between dopaminergic and serotoninergic mechanisms in regulating secretion of human growth hormone (hGH), the effect of cyproheptadine, an antiserotoninergic agent, on l-DOPA-induced hGH secretion was studied in normal subjects. Oral administration of 500 mg of l-DOPA caused a rise in plasma hGH in 6 of 7 subjects studied. This rise in plasma hGH was significantly blunted by the intravenous infusion of 5 mg of cyproheptadine. These results suggest the close relationship between dopamine and serotonin in the control of hGH secretion.
mesh_terms: D000328:Adult; D003533:Cyproheptadine / Q000494:pharmacology*; D004295:Dihydroxyphenylalanine / Q000494:pharmacology*; D013006:Growth Hormone / Q000097:blood / Q000378:metabolism*; D006801:Humans; D008297:Male; D010902:Pituitary Gland / Q000378:metabolism*; D010903:Pituitary Gland, Anterior / Q000187:drug effects / Q000378:metabolism*
chemical_list: D003533:Cyproheptadine; D004295:Dihydroxyphenylalanine; D013006:Growth Hormone