title: DNA strained breakage repair in ataxia telangiectasia fibroblast-like cells.
abstract: Human diploid fibroblast-like cells derived from four patients with the genetic disease ataxia telangiectasia and from two non-mutant donors were examined for the repair of X-ray induced strand breaks in DNA. The ataxia telangiectasia cultures showed no significant differences from the non-mutant cultures in the kinetics and extent of strand repair. This suggests that the increased spontaneous and X-ray induced chromatid aberrations observed in ataxia telangiectasia cells are not caused by a defect in the repair of single strand breaks as might be suspected from a general model of aberration production.
mesh_terms: D000293:Adolescent; D000328:Adult; D001260:Ataxia Telangiectasia / Q000235:genetics* / Q000378:metabolism; D002648:Child; D004247:DNA / Q000528:radiation effects*; D004260:DNA Repair; D005260:Female; D005347:Fibroblasts / Q000378:metabolism / Q000528:radiation effects; D006801:Humans; D008297:Male; D008875:Middle Aged; D011830:Radiation Effects; D014965:X-Rays
chemical_list: D004247:DNA