Delayed type allergy in patients with ulcerative colitis. III. Allergic reactions evoked in colonic mucosa by autologous leukocytes and their extracts.
In 36 patients with ulcerative colitis hypersensitivity reactions induced in the colonic mucosa by autologous leukocytes and their extracts were studied. In 77% of cases reactions developed at the site of leukocyte injection and in 69% of cases at the site of leukocyte extra injection. The time of reaction appearance and the character of histological changes suggest that the reactions were of the cell-mediated type. The results of the investigations indicate that cell-mediated reactions may be an important pathogenic factor in ulcerative colitis.
D000328:Adult; D000941:Antigens; D003093:Colitis, Ulcerative / Q000209:etiology* / Q000276:immunology / Q000473:pathology; D005260:Female; D006801:Humans; D006968:Hypersensitivity, Delayed / Q000150:complications*; D007111:Immunity, Cellular; D007413:Intestinal Mucosa / Q000276:immunology* / Q000473:pathology; D007420:Intestine, Large / Q000276:immunology; D007962:Leukocytes / Q000276:immunology*; D008297:Male; D008875:Middle Aged
D000941:Antigens