title: Pulmonary lesions and autoimmune reactions after long-term nitrofurantoin treatment.
abstract: Hypersensitivity reactions in two women with pulmonary lesions, autoimmune reactions with positive antinuclear factor and liver damage following long-term nitrofurantoin treatment are discussed. One patient had taken nitrofurantoin for more than 1 year and the other for more than 2 when their symptoms appeared. They were in a very poor condition, but recovered when the drug was withdrawn. Lymphocyte transformation test in vitro showed significant blast-transformation, indicating the involvement of immunological mechanisms. Treatment with corticosteroids had not been instituted.
mesh_terms: D001327:Autoimmune Diseases / Q000139:chemically induced*; D056486:Chemical and Drug Induced Liver Injury; D004342:Drug Hypersensitivity / Q000276:immunology; D004417:Dyspnea / Q000139:chemically induced; D005260:Female; D006801:Humans; D008171:Lung Diseases / Q000139:chemically induced*; D008213:Lymphocyte Activation; D008875:Middle Aged; D009582:Nitrofurantoin / Q000009:adverse effects* / Q000627:therapeutic use; D013997:Time Factors
chemical_list: D009582:Nitrofurantoin