[Osteomalcaia and chronic pancreatis. 5 cases].
The authors report five cases of an association between osteomalacia and chronic calcifying pancreatitis. The pancreatic involvement, which was pain-free in four patients, resulted in all cases in enzyme insufficiency with steatorrhoea. The deficiency-type osteopathy was highly vitamin sensitive. Aetiological study of these cases of osteomalacia revealed the constant presence of factors aggravating the vitamin deficiency, playing a role by increasing deficient intake or malabsorption, or by increasing Vitamin D requirements. It thus appears that hypovitaminosis D alone, of particular severity, was sufficient to result in the appearance of clinically evident osteomalacia. Such a vitamin deficiency, necessary when the intestinal mucosa is intact, is only rarely encountered, which accounts for the extreme rarity of osteomalacia in association with chronic pancreatic disorders.
D000328:Adult; D000368:Aged; D002446:Celiac Disease / Q000150:complications; D002908:Chronic Disease; D005260:Female; D006801:Humans; D008286:Malabsorption Syndromes / Q000150:complications; D008297:Male; D008875:Middle Aged; D010018:Osteomalacia / Q000209:etiology*; D010195:Pancreatitis / Q000150:complications*; D014808:Vitamin D Deficiency / Q000150:complications
Ostéomalacie et pancréatite chronique associées. Cinq observations