[Proceedings: Evaluation of the hemodynamic condition during the recuperative phase after the diagnostic isoproterenol test in a patient with coronary disease].
Previous investigations concerning isoproterenol infusion (PI) in the diagnosis of myocardial ischemia have shown that ischemic ECG changes are only significant if they persist or appear after discontinuing PI. In an effort to explain the mechanisms of this delayed response, hemodynamic parameters were measured in 10 patients with angiographically proven coronary disease before, during and after PI. It was found that the principal determinants of myocardial oxygen consumption (TTI and contractility) remain significantly elevated in the recuperation phase, but that aortic pressure and systemic arterial resistance, which diminish during PI, return to pre-infusion levels immediately after halting PI. The combined effects favor the late appearance of ischemic changes in the ECG. The coronary vasodilatation with resultant increased oxygen delivery to the myocardium seen during PI may be sufficient to meet the increased myocardial oxygen demand during PI but disappears immediately if PI is discontinued.
D000328:Adult; D000368:Aged; D001011:Aorta; D001794:Blood Pressure; D003327:Coronary Disease / Q000175:diagnosis*; D006801:Humans; D007545:Isoproterenol; D007773:Lactates / Q000097:blood; D008875:Middle Aged; D010101:Oxygen Consumption; D014655:Vascular Resistance
D007773:Lactates; D007545:Isoproterenol
Evaluation de la condition hémodynamique lors de la phase de récupération après l'épreuve diagnostique à l'isoprotérénol chez le coronarien