Influence of disorders of adrenal function of activity and pharmacokinetics of some neurotropic drugs. I. Influence of adrenalectomy on potency and pharmacokinetics of drugs.
The influence of disorders of adrenal function on pharmacodynamics and biotransformation of selected neurotropic drugs was studied. Pharmacodynamic activity of salicylamide, morphine and hexobarbital were investigated. Pharmacokinetic parameters of salicylamide and hexobarbital were determined.
D000311:Adrenal Glands / Q000502:physiology*; D000315:Adrenalectomy; D000818:Animals; D001711:Biotransformation; D006591:Hexobarbital / Q000378:metabolism / Q000494:pharmacology; D007700:Kinetics; D009020:Morphine / Q000494:pharmacology; D051381:Rats; D012457:Salicylamides / Q000378:metabolism / Q000494:pharmacology; D012890:Sleep / Q000187:drug effects; D013997:Time Factors
D012457:Salicylamides; D009020:Morphine; D006591:Hexobarbital