Midtrimester pregnancy termination by intramuscular injection of a 15-methyl analogue of prostaglandin F2 alpha.
Fifty patients between 12 and 20 weeks' gestation were treated with prostaglandin 15 (S) 15-methyl F2 alpha by repeated intramuscular injection of 250 mug at intervals of not less than 2 hours in order to evaluate its efficacy as an abortifacient. A success rate of 96 per cent was achieved with a mean initiaation-abortion interval of 16.5 +/- S.E.M. 1.12 hours. There were no serious complications. The most common side effects were vomiting in 82 per cent and diarrhea in 66 percent of cases. The abortifacient activity was correlated with serial serum progesterone determinations and continuous intra-amniotic pressure recordings in selected cases.
D000019:Abortifacient Agents; D005260:Female; D005865:Gestational Age; D006801:Humans; D007273:Injections, Intramuscular; D011247:Pregnancy; D011262:Pregnancy Trimester, Second; D011460:Prostaglandins F / Q000008:administration & dosage / Q000009:adverse effects / Q000494:pharmacology*; D014590:Uterine Contraction / Q000187:drug effects
D000019:Abortifacient Agents; D011460:Prostaglandins F