[Activities of molecules similar to carboxyhydroxamic acid chromone-2 (sodium salt) in experimental mercury chloride poisoning; importance of the chromone cycle].
The carbo-hydroxamic-2 chromone acid (sodium salt) shows a higher protective action in vivo than in vitro against mercury chloride induced intoxications. The higher effect observed in vivo might be due to the activity itself of the chromone cycle which added up to that of the carbo-hydroxamic acid function. This latter alone appears in vitro. The antihyaluronidasic properties of this protective agent allow it to prevent the toxic substances to be diffused.
D000818:Animals; D002867:Chromones / Q000627:therapeutic use*; D005260:Female; D006821:Hyaluronoglucosaminidase / Q000037:antagonists & inhibitors; D006877:Hydroxamic Acids / Q000627:therapeutic use*; D066298:In Vitro Techniques; D007770:L-Lactate Dehydrogenase / Q000378:metabolism; D008630:Mercury Poisoning / Q000201:enzymology / Q000517:prevention & control*; D051379:Mice; D013331:Strychnine; D013997:Time Factors
D002867:Chromones; D006877:Hydroxamic Acids; D007770:L-Lactate Dehydrogenase; D006821:Hyaluronoglucosaminidase; D013331:Strychnine
Activités de molécules proches de l'acide chromone carbohydroxamique-2 (sel sodique) vis-à-vis de l'intoxication expérimentale au chlorure mercurique; importance du cycle chromone