Delta 9-tetrahydrocannabinol produced discrimination in pigeons.
In an operant situation pigeons learned to peck one response key 90 min after an injection of 0.25mg/kg delta9-tetrahydrocannabinol (delta9-THC) and another key when trained nondrugged. When tested with doses of delta9-THC lwer than the training dose the birds disciminated 0.20 mg/kg of the drug from the nondrugged state but not 0.15 mg/kg or lower doses. The animals were able to discriminate the drug state from the nondrugged 180 min but not 360 min after the injection At a shorter interval (45 min) both drug and nondrug responding appeared. Cannabinol and cannabidiol (4.0 - 8.0 mg/kg) did not elicit any drug responses, nor did pentobarbital, ditran or amphetamine. Tests with LSD resulted in both drug and nondrug responding. When administering noncannabinoid drugs in combination with delta9-THC 0.15 mg/kg the birds responded at the key associated with the drug state, suggesting interactional effects.
D000818:Animals; D002185:Cannabidiol / Q000494:pharmacology; D002188:Cannabis / Q000494:pharmacology*; D010856:Columbidae; D003517:Cyclopentanes / Q000494:pharmacology; D003913:Dextroamphetamine / Q000494:pharmacology; D004192:Discrimination, Psychological / Q000187:drug effects*; D013759:Dronabinol / Q000494:pharmacology*; D004347:Drug Interactions; D006016:Glycolates / Q000494:pharmacology; D006213:Hallucinogens / Q000494:pharmacology; D008238:Lysergic Acid Diethylamide / Q000494:pharmacology; D008297:Male; D010424:Pentobarbital / Q000494:pharmacology; D012055:Reinforcement Schedule; D013997:Time Factors
D003517:Cyclopentanes; D006016:Glycolates; D006213:Hallucinogens; D002185:Cannabidiol; D013759:Dronabinol; D008238:Lysergic Acid Diethylamide; D010424:Pentobarbital; D003913:Dextroamphetamine