title: The effect of decreased renal artery perfusion pressure on intrarenal hemodynamics in the dog.
abstract: The role of decreased renal artery perfusion pressure in redistribution of renal cortical blood flow during acute hemorrhagic hypotension is unclear. Renal artery hypotension was produced in intact dogs by an intra-aortic balloon catheter placed cephalad to the origins of the renal arteries. Renal cortical perfusion was assessed using selective renal magnification arteriography, isotopically labeled microspheres, and xenon-133 washout. After 60 minutes of decreased renal artery perfusion pressure (40 to 50 mm Hg), no changes were noted in renal cortical perfusion arteriographically. Microsphaere distribution to each cortical zone was unchanged, despite a marked decrease in total renal blood flow and in flow to each zone. 133Xe washout curves permitted two interpretations: Either redistribution of blood flow away from the cortex occurred, or parallel decrease in flow to each zone occurred without redistribution. Results indicate decreased renal artery perfusion pressure does not cause redistribution of renal cortical blood flow in our model.
mesh_terms: D000792:Angiography; D000818:Animals; D004285:Dogs; D007022:Hypotension / Q000000981:diagnostic imaging / Q000503:physiopathology*; D007457:Iodine Radioisotopes; D007668:Kidney / Q000098:blood supply*; D008863:Microspheres; D012039:Regional Blood Flow; D012077:Renal Artery; D014980:Xenon Radioisotopes
chemical_list: D007457:Iodine Radioisotopes; D014980:Xenon Radioisotopes