title: [The role of disorders in the functions of the cerebral catecholamine system in the pathogenesis of chronic alcoholism].
abstract: The authors studied the functions of central and peripheral catecholamine systems in patients with chronic alcoholism. The influence of acute and chronic administration of alcohol was studied in experiments in animals as well as its discontinuation on the catecholamine structures in different areas of the CNS. The obtained data demonstrated that alcohol exerts a specific influence on the catecholamine brain systems which has typical regularities. An analysis of the acheived results permits to assume that the influence of alcohol on the catecholamine brain structures is one of the main links in the pathogenesis of chronic alcoholism.
mesh_terms: D000435:Alcoholic Intoxication / Q000503:physiopathology; D000437:Alcoholism / Q000188:drug therapy / Q000209:etiology*; D001921:Brain / Q000378:metabolism* / Q000503:physiopathology; D002395:Catecholamines / Q000378:metabolism*; D002908:Chronic Disease; D004295:Dihydroxyphenylalanine / Q000378:metabolism; D004298:Dopamine / Q000378:metabolism; D004569:Electroencephalography; D006801:Humans; D007031:Hypothalamus / Q000378:metabolism; D008636:Mesencephalon / Q000378:metabolism; D008734:Methoxyhydroxyphenylglycol / Q000378:metabolism; D009638:Norepinephrine / Q000378:metabolism; D009647:Normetanephrine / Q000378:metabolism
chemical_list: D002395:Catecholamines; D009647:Normetanephrine; D008734:Methoxyhydroxyphenylglycol; D004295:Dihydroxyphenylalanine; D004298:Dopamine; D009638:Norepinephrine
vernacular_title: Rol' narusheniĭ funktsiĭ katekholaminovoĭ sistemy mozga v patogeneze khronicheskogo alkogolizma