Evaluation and selection of optimal solvents and solvent combinations in thin-layer chromatography. Application of the method to basic drugs.
A series of simple mathematical techniques for the evaluation of solvents and solvent combinations in thin-layer chromatography have been investigated. A strategy for the rapid selection of the optimum combination is proposed. It uses classification procedures based on calculation of the similarity between systems. The classification is carried out using a simple graph-theoretical procedure (Kruskal's algorithm) or numerical taxonomy. The selection of optimal sets from the clusters which appear in the classification is based on the information content as derived from Shannon's equation. The method has been applied to an RF data set for basic drugs. It is concluded that these methods indeed allow the selection of optimal systems or combination of systems.
D002855:Chromatography, Thin Layer; D005069:Evaluation Studies as Topic; D008433:Mathematics; D008722:Methods; D004364:Pharmaceutical Preparations; D012997:Solvents / Q000145:classification*; D013597:Systems Analysis
D004364:Pharmaceutical Preparations; D012997:Solvents