title: [Cyclizine-intoxication in six children (author's transl)].
abstract: Cyclizine hydrochloride (Marezine, Echnatol) an antihistaminic drug is commonly used for the treatment of motion sickness. During the past two years we observed six cases of accidental moderate intoxication with an average of 200 mg of cyclizine hydrochloride in children between 2 and 4 years of age. The symptoms became obvious about 1 to 2 hours following ingestion. Among the main symptoms our patients revealed were such as excitement, incoordination, ataxia, athetoid movements and severe hallucinationes. The faces were flushed, the pupils dilated, but dryness of the mouth and hoarseness were never found. Convulsions did not occur. The treatment is purely symtomatic, histamine, apomorphine, phenothiazines and analeptics should not be used.
mesh_terms: D000305:Adrenal Cortex Hormones / Q000627:therapeutic use; D000367:Age Factors; D001259:Ataxia / Q000139:chemically induced; D055598:Chemical Phenomena; D002621:Chemistry; D002675:Child, Preschool; D003501:Cyclizine / Q000506:poisoning*; D004231:Diuresis; D005751:Gastric Lavage; D006212:Hallucinations / Q000139:chemically induced; D006801:Humans; D008297:Male; D009120:Muscle Cramp / Q000139:chemically induced / Q000188:drug therapy; D010634:Phenobarbital / Q000627:therapeutic use; D011041:Poisoning / Q000628:therapy; D012893:Sleep Wake Disorders / Q000139:chemically induced
chemical_list: D000305:Adrenal Cortex Hormones; D003501:Cyclizine; D010634:Phenobarbital
vernacular_title: Cyclizinvergiftung im Kindesalter