[Some characteristics of fucidin biosynthesis].
Some features of fusidin biosynthesis by 2 strains of Fusidium coccineum were studied proceeding from the peculiar properties of the antibiotic molecule structure. It was found that an increase in the levels of the carbon sources in the medium stimulated the biosynthesis of fusidin, while excessive concentrations of nitrogen especially in its inorganic and amino acidpeptide forms stimulated the organism growth and lowered the antibiotic activity levels. The concentration of nitrogen in the medium is considered as one of the possible control mechanisms in the processes of the fungus growth and biosynthesis of fusidin.
D050260:Carbohydrate Metabolism; D003470:Culture Media; D004305:Dose-Response Relationship, Drug; D005672:Fusidic Acid / Q000096:biosynthesis*; D003904:Mitosporic Fungi / Q000254:growth & development / Q000378:metabolism; D008968:Molecular Conformation; D009584:Nitrogen / Q000378:metabolism; D013172:Spores, Fungal; D013268:Stimulation, Chemical; D013997:Time Factors
D003470:Culture Media; D005672:Fusidic Acid; D009584:Nitrogen
Nekotorye osobennosti biosinteza fuzidina