[The effect of phenamine on the avoidance reaction in intact and striatectomized rats].
Various characteristics of a conditioned avoidance reaction were recorded in rats in a Y-maze. Small doses of d,l-amphetamine (0.5 mg/kg) facilitated avoidance response while large ones (5 mg/kg) worsened it. After ablation of the rostral part of the striatum, small doses of the drug had the same effect as before, but no deteriorating action of large doses was observed. The behaviour disturbance is related to the capacity of d,l-amphetamine for activating the nigro-striatal dopaminergic transmission.
D000661:Amphetamine / Q000494:pharmacology*; D000818:Animals; D001362:Avoidance Learning / Q000187:drug effects* / Q000502:physiology; D001931:Brain Mapping; D003342:Corpus Striatum / Q000502:physiology*; D004305:Dose-Response Relationship, Drug; D005260:Female; D008297:Male; D051381:Rats
D000661:Amphetamine
Vliianie fenamina na reaktsiiu izbeganiia u intaktnykh i striatéktomirovannykh krys