title: Distribution of fibrinogen, and platelet factors 4 and XIII in subcellular fractions of human platelets.
abstract: The distribution of fibrinogen, platelet factor 4 (heparin-neutralizing factor) and factor XIII amongst subcellular fractions of human platelets was determined. It was found that fibrinogen and platelet factor 4 peaked sharply in the region of the density gradient previously shown to be heavily enriched with alpha-granules. By contrast, factor XIII, fibrin-stabilizing factor, was found exclusively in the supernatant.
mesh_terms: D001779:Blood Coagulation Factors / Q000032:analysis*; D001792:Blood Platelets / Q000032:analysis* / Q000378:metabolism; D005176:Factor XIII / Q000032:analysis*; D005340:Fibrinogen / Q000032:analysis*; D006493:Heparin / Q000494:pharmacology; D006801:Humans; D010978:Platelet Factor 4 / Q000032:analysis*; D012701:Serotonin / Q000378:metabolism; D013347:Subcellular Fractions / Q000032:analysis
chemical_list: D001779:Blood Coagulation Factors; D012701:Serotonin; D010978:Platelet Factor 4; D005340:Fibrinogen; D006493:Heparin; D005176:Factor XIII