Bone volume and mineral density of iliac crest spongiosa in uremia.
Bone mass and bone mineral content were measured in non-dialyzed and dialyzed uremic patients. Bone mass, measured by micromorphometry and a gas displacement method, was higher in uremic than in age and sex matched control subjects (micromorphometry-U:25.8 +/- 8.24%; Co:15.6 +/- 4.38; gas displacement-U:211 +/- 66 mm3/cm3; Co:191 +/- 45). In hemodialyzed patients, bone mass was lower the longer the patients had been on dialysis (r = 0.38; P 0.05). Bone mineral content (specific weight) was diminished in uremia (1.82 +/- 0.095 g/ml; controls 1.854 +/- 0.0173). In hemodialyzed patients, specific weight was higher, as was Ca content of bone assessed by neutron activation analysis. It is concluded, that negative Ca balance was the major cause of bone loss and that bone loss is thus preventable.
D001862:Bone Resorption / Q000209:etiology; D001842:Bone and Bones / Q000378:metabolism / Q000503:physiopathology*; D002118:Calcium / Q000378:metabolism; D006801:Humans; D007085:Ilium / Q000503:physiopathology; D008264:Macrophages / Q000503:physiopathology*; D008903:Minerals / Q000032:analysis; D010587:Phagocytosis; D006435:Renal Dialysis; D012882:Skin Tests; D014511:Uremia / Q000150:complications / Q000503:physiopathology*
D008903:Minerals; D002118:Calcium