[Immunogenesis and nonspecific factors of natural resistance. XI. Further study of the depression mechanism of humoral reactions of natural immunity during the vaccinal process].
The mechanisms of depression of humoral reactions of natural immunity under the effect of vaccination were studied further. Experiments were carried out on albino rats tolerant to the horse serum protein. Administration of the antigen to the tolerant animals failed to cause formation of antibodies or to influence humoral factors of natural immunity. As to rats not immunized earlier, complement-fixing antibodies were revealed from the 7th to the 21st days after the administration of horse serum; simultaneously there was seen depression of the humoral mechanisms of natural resistance. The results obtained confirmed the hypothesis stating that there existed competitive relations between the specific and nonspecific immunological reaction in the fight for plastic provision of the corresponding reactions.
D000818:Animals; D000906:Antibodies / Q000032:analysis; D000917:Antibody Formation; D000941:Antigens; D001798:Blood Proteins / Q000276:immunology*; D003168:Complement Fixation Tests; D006736:Horses / Q000276:immunology; D007108:Immune Tolerance; D007109:Immunity; D007165:Immunosuppression Therapy; D051381:Rats; D014611:Vaccination
D000906:Antibodies; D000941:Antigens; D001798:Blood Proteins
Immunogenez i nespetsificheskie faktory estestvennoi rezistentnosti. Soobshchenie XI. Dal'neishee isuchenie mekhanizmov podavleniia gumoral'nykh reaktsii estestvennogo immuniteta v khode vaktsinal'nogo protsessa