title: [Genetic control of lactate dehydrogenase gene A expression in sheep erythrocytes].
abstract: Polymorphism for the phenotypical expression of gene for LDH subunit A was demonstrated in sheep erythrocytes by means of starch gel electrophoresis. Three types of LDH were established differing in the relative activities of the second and third LDH isozymes. Familial analysis has shown that high level of LDH-2 and LDH-3 activities are determined by the autosomal gene Ldr-1a and low level of their activities is controlled by gene Ldr-1b. The frequencies of gene Ldr-1a in Altai thin-fleece, Romney Marsh and Linkoln breeds were 0,533; 0,509 and 0,425 respectively. Gene frequencies were also determined in crossbreeds. Possible mechanisms of the action of genes Ldr-1a and Ldr-1b in sheep erythrocytes are discussed.
mesh_terms: D000818:Animals; D004912:Erythrocytes / Q000201:enzymology*; D007527:Isoenzymes; D007770:L-Lactate Dehydrogenase / Q000097:blood*; D010641:Phenotype; D011110:Polymorphism, Genetic; D012756:Sheep / Q000097:blood*
chemical_list: D007527:Isoenzymes; D007770:L-Lactate Dehydrogenase
vernacular_title: Geneticheskiĭ kontrol' ékspressii gena A laktatdegidrogenazy v éritrotsitakh ovets