Relationship between the changes in the concentration of endoxan and the activity of kininforming enzymes within the Guérin tumor in rat.
The activity of rat kininforming system and endoxan level in certain organs and in the neoplastic tissue was studied. It was found that trypsin increases markedly the kininforming activity and endoxan level in the Guérin tumor, and slightly in the liver. A direct correlation between the level of endoxan when given with trypsin and the kinin activity were observed. The authors suppose that the selective accumulation of endoxan in the tumor depends on the trypsin -- induced activation of kininforming system within the neoplastic tissue.
D000818:Animals; D001769:Blood / Q000378:metabolism; D003520:Cyclophosphamide / Q000378:metabolism* / Q000494:pharmacology; D004357:Drug Synergism; D007668:Kidney / Q000378:metabolism; D007704:Kininogens / Q000378:metabolism*; D008099:Liver / Q000378:metabolism; D008168:Lung / Q000378:metabolism; D008297:Male; D009132:Muscles / Q000378:metabolism; D009374:Neoplasms, Experimental / Q000201:enzymology*; D051381:Rats; D013154:Spleen / Q000378:metabolism; D014357:Trypsin / Q000494:pharmacology
D007704:Kininogens; D003520:Cyclophosphamide; D014357:Trypsin