Immune responses of inbred guinea pigs against random terpolymers containing L glutamic acid and L alanine.
The immune responses of the inbred guinea pig strains 2 and 13 have been determined against random terpolymers of L glutamic acid and L alanine and a third amino acid. Strain 2 guinea pigs responded against GAT10, GAT20(LLD), GAT10(NO2)15, GAT4, and GAL10. However, strain 13 guinea pigs responded only against GAT10. The explanation offered is that strain 2 guinea pigs, which have the Ir-GA gene, recognize the polymers via random GA determinants present in sufficient concentration in all of the above polymers. However, strain 13 guinea pigs recognize the GAT10 via the Ir-GT gene, and reduction in the concentration of tyrosyl residues below 10 mole % by various procedures alters the concentration of available random GT determinants necessary for interaction with the gene product of the Ir-GT gene.
D000409:Alanine / Q000276:immunology*; D000818:Animals; D000917:Antibody Formation; D000941:Antigens; D001666:Binding Sites, Antibody; D005260:Female; D005971:Glutamates / Q000276:immunology*; D006168:Guinea Pigs / Q000276:immunology*; D006968:Hypersensitivity, Delayed; D007104:Immune Adherence Reaction; D007930:Leucine / Q000276:immunology; D008297:Male; D008970:Molecular Weight; D011108:Polymers / Q000276:immunology*; D014443:Tyrosine / Q000276:immunology
D000941:Antigens; D005971:Glutamates; D011108:Polymers; D014443:Tyrosine; D007930:Leucine; D000409:Alanine