Reduced antibody-dependent cell-mediated cytotoxicity in systemic lupus erythematosus.
The peripheral blood mononuclear cells from twenty-three patients with SLE were studied. They showed a reduction in antibody-dependent cell-mediated cytotoxicity. This reduction was significantly related to disease activity. No correlations were found with other clinical features. Some of the possible explanations for this finding are discussed.
D000328:Adult; D000906:Antibodies; D002460:Cell Line; D003601:Cytotoxicity Tests, Immunologic; D005260:Female; D006801:Humans; D007111:Immunity, Cellular; D007958:Leukocyte Count; D008180:Lupus Erythematosus, Systemic / Q000276:immunology*; D008214:Lymphocytes / Q000276:immunology; D008297:Male; D009000:Monocytes / Q000276:immunology
D000906:Antibodies