The effect of angrod on the delayed hypersensitivity response in rats.
Delayed hypersensitivity was induced in rats by means of sheep erythrocytes and bovine serum albumin-lipid conjugate. Administration of heparin to rats sensitized to either antigen resulted in diminution of the delayed hypersensitivity reaction. Administration of ancrod, however, failed to inhibit the delayed cellular reaction to either antigen. Granuloma formation remained unaffected when rats were injected with either heparin or ancrod. The lack of ancrod effect, in contrast to heparin effect, on delayed hypersensitivity is discussed.
D000721:Ancrod / Q000494:pharmacology*; D000818:Animals; D010450:Endopeptidases / Q000494:pharmacology*; D004912:Erythrocytes / Q000276:immunology; D005260:Female; D005340:Fibrinogen / Q000032:analysis; D006493:Heparin / Q000494:pharmacology; D006968:Hypersensitivity, Delayed / Q000276:immunology* / Q000473:pathology; D051381:Rats; D012710:Serum Albumin, Bovine / Q000276:immunology; D012867:Skin / Q000473:pathology; D012882:Skin Tests
D012710:Serum Albumin, Bovine; D005340:Fibrinogen; D006493:Heparin; D010450:Endopeptidases; D000721:Ancrod