[Effect of various amino acids and their antagonists on the cholinergic tremor and acetylcholine release in the CNS of the rat].
Glycine and GABA administered intraventricularly and intrastriatally were found to inhibit the oxotremorin tremor in rats. The two amino acids reduce both the spontaneous release of acetylcholine into the ventricle and the discharge measured under oxotremorin treatment. The inhibition of the tremor and of acetylcholine release can be blocked by amino acid antagonists (strychnine and picrotoxin), whose effects are not specific for one of these amino acids; this action can be interpreted as effect of interference with other central transmission systems. Structures located close to the ventricles (nigrostriatal path ways) are discussed as possible points of action.
D000109:Acetylcholine / Q000378:metabolism*; D000613:Aminobutyrates / Q000494:pharmacology*; D000818:Animals; D005260:Female; D018756:GABA Antagonists; D005998:Glycine / Q000037:antagonists & inhibitors / Q000494:pharmacology* / Q000627:therapeutic use; D010095:Oxotremorine; D051381:Rats; D014202:Tremor / Q000188:drug therapy*; D005680:gamma-Aminobutyric Acid / Q000494:pharmacology* / Q000627:therapeutic use
D000613:Aminobutyrates; D018756:GABA Antagonists; D005680:gamma-Aminobutyric Acid; D010095:Oxotremorine; D000109:Acetylcholine; D005998:Glycine
Wirkung verschiedener Aminosäuren und deren Antagonisten auf den cholinergen Tremor und die Azetylcholinfreisetzung im ZNS der Ratte