Failure of permanent marrow ablation to induce a myeloproliferative disorder in rabbits.
Rabbits in which bone marrow necrosis is induced often develop myeloproliferation with extra-medullary hemopoiesis. There is a study suggesting that a similar event ensues after mechanical marrow ablation. To investigate the latter phenomenon, we flushed and curretted the long bones of rabbits and then plugged their marrow cavities permanently preventing marrow regeneration. Four-8-long bones per rabbit were ablated by this technique. Serial blood evaluations were performed and upon death or sacrifice autopsies were performed. Some animals were followed up to one year. None developed any sigh of a myeloproliferative disorder as judged by leukocytosis, peripheral blood morphology and organ examination for extramedullary hemopoiesis.
D000818:Animals; D001855:Bone Marrow Diseases / Q000150:complications*; D006410:Hematopoiesis; D007668:Kidney / Q000473:pathology; D008099:Liver / Q000473:pathology; D009196:Myeloproliferative Disorders / Q000209:etiology*; D009336:Necrosis / Q000150:complications; D009929:Organ Size; D011817:Rabbits; D013154:Spleen / Q000473:pathology