Long-term intramuscular administration of triamcinolone acetonide. Effect on the hypothalamic-pituitary-adrenal axis.
Five patients received intramuscular injections of triamcinolone acetonide for periods ranging from five months to three years. Metyrapone tartrate testing was used to assess the function of the hypothalamic-pituitary-adrenal (HPA) axis during, after, and, in one case, before the drug therapy. The HPA axis function was found to be suppressed during the period of treatment and up to ten months after cessation of therapy. Lens opacities appeared in two of the five patients while they were receiving triamcinolone acetonide. Results of this study indicate that patients to whom triamcinolone acetonide has been administered should be given supportive doses of corticosteroids during stressful situations (eg, major surgery). They should also receive ophthalmologic examinations every three to six months while they are receiving the medication.
D000311:Adrenal Glands / Q000187:drug effects* / Q000503:physiopathology; D000328:Adult; D006801:Humans; D007031:Hypothalamus / Q000187:drug effects* / Q000503:physiopathology; D007273:Injections, Intramuscular; D008297:Male; D008797:Metyrapone; D008875:Middle Aged; D010902:Pituitary Gland / Q000187:drug effects* / Q000503:physiopathology; D011565:Psoriasis / Q000188:drug therapy; D014222:Triamcinolone Acetonide / Q000008:administration & dosage* / Q000009:adverse effects / Q000494:pharmacology / Q000627:therapeutic use
D014222:Triamcinolone Acetonide; D008797:Metyrapone