[Study of the increased efficacy of heparin due to carbenicillin].
On 15 patients in the in-vitro-experiment the effect of carbenicillin on the collagen-induced aggregation of platelets and the release of the platelet factor 4 neutralising heparin is examined. In a high dosage carbenicillin leads to an inhibition of these platelet functions. Therefore, a combination of carbenicillin with heparin may cause an increased readiness for haemorrhage for the patient.
D001777:Blood Coagulation / Q000187:drug effects; D001792:Blood Platelets / Q000187:drug effects* / Q000502:physiology; D002228:Carbenicillin / Q000494:pharmacology*; D003094:Collagen; D006493:Heparin / Q000494:pharmacology*; D006801:Humans; D010974:Platelet Aggregation / Q000187:drug effects; D010978:Platelet Factor 4
D010978:Platelet Factor 4; D006493:Heparin; D003094:Collagen; D002228:Carbenicillin
Untersuchungen über die Wirkungssteigerung von Heparin durch Carbenicillin