title: [Effectiveness of pharmacological preparations in physical exertion].
abstract: The effect of some drugs used as stimulants of physical performance was measured. The effectiveness was assessed in animals (mice) by means of the Kiplinger swimming procedure and in humans with the aid of the PWC170 test and physiological parameters (respiration rate, pulse rate, oxygen consumption, oxyhemogram, blood flow rate, rate of oxygen consumption by skin -- Epstein constant). Ephedrine, strychnine, indocete and eleuterococcus were used as stimulants. In animal and human experiments the best results were obtained from the use of an ephedrine-strychnine mixture; the dose for mice -- 0,03 and 0.01 mg/kg, for men -- 0.3 and 0.0015 mg/kg twice a day per os for 10-15 days.
mesh_terms: D000818:Animals; D004809:Ephedrine / Q000494:pharmacology*; D006801:Humans; D007213:Indomethacin / Q000494:pharmacology; D051379:Mice; D005082:Physical Exertion / Q000187:drug effects*; D010936:Plant Extracts / Q000494:pharmacology*; D013331:Strychnine / Q000494:pharmacology*
chemical_list: D010936:Plant Extracts; D004809:Ephedrine; D013331:Strychnine; D007213:Indomethacin
vernacular_title: Izuchenie éffektivnosti farmakologicheskikh veshchestv pri fizicheskikh nagruzkakh