[A histochemical study of brain tissue in experimental convulsive seizures (componetns of acetylcholine metabolism)].
The author studied substances related to acetylcholine metabolism (acetylcholinesterase, non-specific acetylcholinesterase, SH, SS-groups, histidine, Ca) using histochemical methods. There was an increase in the intensity of reactions on SH-groups and Ca, and a rise in the staining degree on SS-groups and acetylcholinesterase in the subconvulsive phase of the stroke. These shifts were more significant in the brain stem. A generalization of convulsive strokes intensifies the given changes and causes an increase of the intensity of the reactions on histidine after the end of the stroke (after 1, 3, 6, 24, 48 and 72 hours). A normalization of the studied reactions happens at different times in the different brain areas and does not end completely even 72 hours following discontinuance of the convulsions. The author comes to the conclusion that the acetylcholine metabolism is inhibited during the covulsive stroke.
D000109:Acetylcholine / Q000378:metabolism*; D000110:Acetylcholinesterase / Q000378:metabolism; D000161:Acoustic Stimulation / Q000009:adverse effects; D000818:Animals; D001921:Brain / Q000201:enzymology / Q000378:metabolism*; D001923:Brain Chemistry; D002118:Calcium / Q000378:metabolism; D004220:Disulfides / Q000378:metabolism; D006639:Histidine / Q000378:metabolism; D006651:Histocytochemistry; D008297:Male; D009044:Motor Cortex / Q000378:metabolism; D010433:Pentylenetetrazole; D011689:Purkinje Cells / Q000201:enzymology / Q000378:metabolism; D051381:Rats; D012640:Seizures / Q000201:enzymology / Q000209:etiology / Q000378:metabolism*; D013003:Somatosensory Cortex / Q000378:metabolism; D013438:Sulfhydryl Compounds / Q000378:metabolism
D004220:Disulfides; D013438:Sulfhydryl Compounds; D006639:Histidine; D000110:Acetylcholinesterase; D000109:Acetylcholine; D002118:Calcium; D010433:Pentylenetetrazole
Gistokhimicheskoe issledovanie tkani mozga pri éksperimental'nom sudorozhnom pripadke (komponenty obmena atsetilkholina)