title: Interactions between vagus nerve stimulation and pentagastrin or secretin on the guinea pig gallbladder.
abstract: In guinea pigs, anaesthetised with urethane, stimulation of the peripheral cut end of the cervical vagus activates cholinergic excitatory and non-adrenergic inhibitory fibres to the gallbladder. Central vagal stimulation reflexly contracts the gallbladder by an efferent pathway in the vagus and also activates an adrenergic, non-vagal inhibitory pathway to the gallbladder. Injections of pentagastrin (12-33 mug kg-1 s.c.) or secretin (0.1-0.2 U kg-1 i.a.), doses which produce no effect on gallbladder tone when administered alone, significantly increase the contractions evoked by vagal stimulation.
mesh_terms: D000818:Animals; D004525:Efferent Pathways / Q000502:physiology; D004558:Electric Stimulation; D005071:Evoked Potentials / Q000187:drug effects; D005260:Female; D005704:Gallbladder / Q000187:drug effects*; D006168:Guinea Pigs; D008297:Male; D010418:Pentagastrin / Q000494:pharmacology*; D011312:Pressure; D012633:Secretin / Q000494:pharmacology*; D013268:Stimulation, Chemical; D014630:Vagus Nerve / Q000502:physiology*
chemical_list: D012633:Secretin; D010418:Pentagastrin