title: Viscosity and gelation studies in deer hunting hemoglobins.
abstract: Sickling, viscosity and gelling properties of the red cells and the hemoglobins of three Virginia white-tailed deer homozygous for types II and III (the sickling types) and V (the nonsickling type), respectively, have been analyzed. The sickling of erythrocytes of deer with type II or III is inhibited by urea and cyanate at concentrations which are comparable to those used in in vitro studies of red cells from patients with sickle cell anemia. No differences were observed between the viscosities of the three deer hemoglobin types at temperatures of 12 degrees C or above. High concentrations of deer hemoglobin types II and III gelled at 1 degree C and at pH values of 7.4-7.7; the minimum gelling concentration of type II was 33.5 g% and of type III was 38 g%. Gel formation was not observed at pH values between 6.7-7.1. Hemoglobin type V did not gel and prevented the formation of gels of type II and III in mixtures at pH 7.6-7.7.
mesh_terms: D000755:Anemia, Sickle Cell; D000818:Animals; D001809:Blood Viscosity; D003485:Cyanates / Q000494:pharmacology; D003670:Deer / Q000097:blood*; D004195:Disease Models, Animal; D005782:Gels; D006454:Hemoglobins; D006455:Hemoglobins, Abnormal; D010108:Oxyhemoglobins; D014508:Urea / Q000494:pharmacology
chemical_list: D003485:Cyanates; D005782:Gels; D006454:Hemoglobins; D006455:Hemoglobins, Abnormal; D010108:Oxyhemoglobins; D014508:Urea