[Hemodynamic effects of the intravenous form of acebutolol].
Acetubolol was administered intravenously to 11 patients with various heart disorders, without any adverse effects. The bradycardic effect of this compound is slight. It did not change the auriculo-ventricular conduction in 10 patients with sinus rhythm. The effect of acebutolol on myocardial efficacy is slight or absent in controls. At the doses studied, it did not alter systolic arterial pressure. Furthermore, the effect on the myocardial contractility is slight (-10 p.cent, mean). The important point noted is that the drug does not increase the pressure in ventricular filling, the first sign usually of left ventricular insufficiency caused by most other drugs of this pharmacological type.
D000070:Acebutolol / Q000494:pharmacology*; D000328:Adult; D001794:Blood Pressure / Q000187:drug effects; D002302:Cardiac Output / Q000187:drug effects; D005260:Female; D006321:Heart / Q000187:drug effects*; D006329:Heart Conduction System / Q000187:drug effects; D006331:Heart Diseases / Q000503:physiopathology; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D007275:Injections, Intravenous; D008297:Male; D008875:Middle Aged; D009200:Myocardial Contraction / Q000187:drug effects; D010101:Oxygen Consumption / Q000187:drug effects; D014655:Vascular Resistance / Q000187:drug effects
D000070:Acebutolol
Etude des effets hémodynamiques de l'acébutolol sous forme intraveineuse