[Surgical treatment of Sipple's syndrome (author's transl].
Sipple's syndrome (bilateral phaeochromocytoma and medullary thyroid carcinoma) is a multiple endocrinopathy with a familial occurrence. The medullary thyroid carcinoma develops from the intrathyroidal C-cells. Radioimmunological analysis of serum calcitonin, basally or after calcium infusion, discloses the tumor also in asymptomatic members of the families. The patients are treated in two sessions. In the first a bilateral adrenalectomy is performed and in the second a total thyroidectomy with modified neck dissection. Major preoperative diagnostic procedures as angiograms and phlebograms as well as the bilateral adrenalectomy must be preceded by pre-treatment with alpha- and beta- receptorblocking substances.
D000328:Adult; D002116:Calcitonin / Q000378:metabolism; D002395:Catecholamines / Q000378:metabolism; D005260:Female; D006801:Humans; D008297:Male; D010282:Parathyroid Neoplasms / Q000235:genetics / Q000601:surgery*; D010673:Pheochromocytoma / Q000235:genetics / Q000601:surgery*; D013577:Syndrome; D013964:Thyroid Neoplasms / Q000235:genetics / Q000601:surgery*
D002395:Catecholamines; D002116:Calcitonin