Effect of ethanol on phospholipid metabolism by the rat lung.
Prefeeding of alcohol shows the in vivo incorporation of orally administered palmitic acid into phosphatidylcholine of the lung. This impairment is also demonstrable in vitro utilizing lung slices and 14C-labeled palmitate or cytidine 5'-diphosphocholine as precursors. It is concluded that alcohol ingestion affects the utilization of precursors needed for phospholipid formation in the lung.
D000818:Animals; D003566:Cytidine Diphosphate Choline / Q000378:metabolism; D003864:Depression, Chemical; D000431:Ethanol / Q000494:pharmacology*; D005260:Female; D066298:In Vitro Techniques; D007408:Intestinal Absorption; D008168:Lung / Q000187:drug effects / Q000378:metabolism*; D010169:Palmitic Acids / Q000378:metabolism; D010713:Phosphatidylcholines / Q000096:biosynthesis; D010743:Phospholipids / Q000378:metabolism*; D051381:Rats
D010169:Palmitic Acids; D010713:Phosphatidylcholines; D010743:Phospholipids; D000431:Ethanol; D003566:Cytidine Diphosphate Choline