Reduction of hypoxia-induced disturbances by previous treatment with benserazide and L-dopa in rats.
Pretreatment by benserazide (50 mg/kg i.p.) and L-Dopa (100 mg/kg i.p.) in rats induces a reduction of the diminution of motility after hypoxia and a stabilization of cerebral blood flow during and after hypoxia. An overload of cerebral dopamine and norepinephrine seems to be the original process of this phenomenon.
D000818:Animals; D001545:Benserazide / Q000494:pharmacology / Q000627:therapeutic use*; D001923:Brain Chemistry; D002245:Carbon Dioxide / Q000097:blood; D002560:Cerebrovascular Circulation / Q000187:drug effects; D004298:Dopamine / Q000032:analysis; D005260:Female; D006834:Hydrazines / Q000627:therapeutic use*; D000860:Hypoxia / Q000188:drug therapy* / Q000503:physiopathology; D007980:Levodopa / Q000494:pharmacology / Q000627:therapeutic use*; D009043:Motor Activity / Q000187:drug effects; D009638:Norepinephrine / Q000032:analysis; D010100:Oxygen / Q000097:blood; D051381:Rats
D006834:Hydrazines; D002245:Carbon Dioxide; D007980:Levodopa; D001545:Benserazide; D010100:Oxygen; D004298:Dopamine; D009638:Norepinephrine