title: Aspects of anaesthetic management of heterologous extracorporeal hepatic support in patients with acute liver failure.
abstract: Some anaesthetic aspects of heterologous extracorporeal hepatic support for patients with acute liver failure have been investigated in animals and men. Two types of anaesthesia during hepatectomy in pigs were performed in 20 experiments divided into two groups. A convenient anaesthetic technique was found to be the combined use of neuroleptanalgesics, gamma-OH, small doses of thiopental sodium and nitrous oxide--oxygen mixture. The necessity for care in the procedure of temporary liver support for 'poor-risk' patients is outlined. A minimal use of drugs which are metabolized by the liver, and avoidance of potent analgesics, narcotics, hypotension and hypoxia are the main principles for safe extracorporeal hepatic assistance to critically ill patients.
mesh_terms: D000328:Adult; D000768:Anesthesia, General / Q000379:methods*; D000818:Animals; D005069:Evaluation Studies as Topic; D005112:Extracorporeal Circulation / Q000009:adverse effects / Q000379:methods*; D005260:Female; D006498:Hepatectomy; D006801:Humans; D008099:Liver / Q000378:metabolism; D008102:Liver Circulation; D008107:Liver Diseases / Q000628:therapy*; D009458:Neuroleptanalgesia; D011229:Preanesthetic Medication / Q000379:methods; D013552:Swine