Effects of cholestyramine on 1,2-dimethylhydrazine-induced enteric carcinoma in germfree rats.
Oral administration of 1,2-dimethylhydrazine (DMH) induced intestinal neoplasms in germfree rats. A supplement of 2% cholestyramine resin in the diet increased the frequency of DMH-induced intestinal tumors and accelerated malignant transformation. Bile acids in the cecal content were determined with and without cholestyramine in order to obtain a correlation between the bile acid metabolism and the enteric carcinogenesis.
D000230:Adenocarcinoma / Q000139:chemically induced* / Q000473:pathology; D000818:Animals; D001647:Bile Acids and Salts / Q000378:metabolism*; D002273:Carcinogens; D002432:Cecum / Q000378:metabolism; D002792:Cholestyramine Resin / Q000633:toxicity*; D004127:Dimethylhydrazines; D004357:Drug Synergism; D005260:Female; D005856:Germ-Free Life; D006834:Hydrazines; D007414:Intestinal Neoplasms / Q000139:chemically induced* / Q000473:pathology; D008297:Male; D009368:Neoplasm Transplantation; D009374:Neoplasms, Experimental / Q000139:chemically induced; D051381:Rats
D001647:Bile Acids and Salts; D002273:Carcinogens; D004127:Dimethylhydrazines; D006834:Hydrazines; D002792:Cholestyramine Resin