[Animal experiment studies on the effect of vitamin A on cortisol-induced wound healing disorders].
In animal experiments on rats we could show that wound healing, inhibited by cortison can be normalized by vitamin A administration. The reason for this behaviour is assumed to be an antagonistic effect of cortison and vit. A via the inflammatory phase on the amount of newly formed collagen. The increase of the alpha 1 and alpha 2 globulin fraction and the decrease of the albumin fraction in the serum caused by vitamin A seems to indicate this fact as well as the pronounced leucocyte depression under cortisol treatment.
D000818:Animals; D006854:Hydrocortisone / Q000009:adverse effects*; D008297:Male; D011183:Postoperative Complications / Q000139:chemically induced*; D051381:Rats; D014801:Vitamin A / Q000037:antagonists & inhibitors / Q000494:pharmacology / Q000627:therapeutic use*; D014945:Wound Healing / Q000187:drug effects*
D014801:Vitamin A; D006854:Hydrocortisone
Tierexperimentelle Untersuchungen über die Beeinflussung Cortisol-induzierter Wundheilungsstörungen durch Vitamin A