[Intravaginal infection of the rat with Trichomonas vaginalis and Candida albicans. An experimental model for chemotherapy (author's transl)].
Ovariectomised and oestrogen premedicated rats were infected intravaginally, with first C. albicans and then with T. vaginalis. Under these conditions infections with T. vaginalis could be established with more reliability than when using axenically-cultivated T. vaginalis alone. This mode of infection is easily reproduced, and it allows the performance of chemotherapeutic tests on small groups of laboratory animals. Such tests were carried out with Metronidazole, Tinidazole and Nifuratel.
D000818:Animals; D000994:Antitrichomonal Agents / Q000627:therapeutic use*; D002181:Candidiasis, Vulvovaginal / Q000150:complications; D004195:Disease Models, Animal; D004353:Drug Evaluation, Preclinical / Q000379:methods; D005260:Female; D008795:Metronidazole / Q000627:therapeutic use; D009545:Nifuratel / Q000627:therapeutic use; D051381:Rats; D014011:Tinidazole / Q000627:therapeutic use; D014247:Trichomonas Vaginitis / Q000150:complications / Q000188:drug therapy*
D000994:Antitrichomonal Agents; D014011:Tinidazole; D008795:Metronidazole; D009545:Nifuratel
Intravaginale Infektionen der Ratte mit Trichomonas vaginalis und Candida albicans: Ein Modell zur experimentellen Chemotherapie