Effect of carbon-tetrachloride and mercuric chloride on the tocopherol and ubiquinone content of liver and kidney.
Authors examined changes in the total ubiquinone and tocopherol contents of livers and kidneys obtained from rats acutely poisoned by carbon-tetrachloride and mercuric-chloride. Following administration of carbon-tetrachloride after 48 h the liver ubiquinone content per 100 g tissue decreased from 11.80 +/- 2.44 mg to 7.24 +/- 2.15 mg, while the kidney ubiquinone content changed from 14.16 +/- 3.96 mg to 5.98 +/- 2.93 mg. The total tocopherol content remained unaltered. Fourty-eight hours after administration of mercuric-chloride, the liver total tocopherol and total ubiquinone contents showed no changes, the tocopherol content of the kidney dropped from 6.16 +/- 2.10 mg to 3.16 +/- 1.48 mg, while the total ubiquinone content remained unaltered.
D000818:Animals; D002252:Carbon Tetrachloride Poisoning / Q000378:metabolism*; D008099:Liver / Q000378:metabolism*; D008630:Mercury Poisoning / Q000378:metabolism*; D051381:Rats; D014810:Vitamin E / Q000378:metabolism*
D014810:Vitamin E