Hepatic peroxisome proliferation: induction by two novel compounds structurally unrelated to clofibrate.
Two hypolipidemic compounds [ 4-chloro-6(2,3-xylidino)-2-pyrimidinyl-thio] acetic acid, and 2-chloro-5(3,5-dimethylpiperidinosufony)benzoic acid (tibric acid) greatly increased the number of peroxisomes (microbodies) in liver cells of rats and mice. This augmented peroxisome population was accompanied by significant elevation of liver catalase activity. These two hypolipidemic peroxisome proliferators are structurally different from ethyl a-p-chlorophenozyisobutyrate (clofibrate) and other hypolipidemic, arylocyisobutyrate derivatives which cause hepatic peroxisome proliferation. Induction of peroxisome proliferation by these structurally unrelated hypolipidemic compounds suggests a possible relation between hepatic peroxisome proliferation and hypolipidemia.
D000818:Animals; D001565:Benzoates / Q000494:pharmacology; D002374:Catalase / Q000378:metabolism; D004305:Dose-Response Relationship, Drug; D000960:Hypolipidemic Agents / Q000494:pharmacology*; D008099:Liver / Q000033:anatomy & histology / Q000187:drug effects* / Q000648:ultrastructure; D008297:Male; D051379:Mice; D008830:Microbodies / Q000187:drug effects* / Q000201:enzymology / Q000378:metabolism; D009929:Organ Size; D009940:Organoids / Q000187:drug effects*; D010880:Piperidines / Q000494:pharmacology*; D011743:Pyrimidines / Q000494:pharmacology*; D051381:Rats; D011916:Rats, Inbred F344; D013329:Structure-Activity Relationship; D013450:Sulfones / Q000494:pharmacology; D014992:Xylenes / Q000494:pharmacology
D001565:Benzoates; D000960:Hypolipidemic Agents; D010880:Piperidines; D011743:Pyrimidines; D013450:Sulfones; D014992:Xylenes; D002374:Catalase