Studies on the effect of 17alpha-ethinyl-6-estrene-5alpha, 7beta-diol on menstrual cycle and plasma and urinary hormones in normal women.
Pharmacological tests on rats and dogs showed that a novel steroid substance, ORG OI-65 (code name for 17alpha-ethinyl-6-estrene-5alpha, 7beta-diol) has both progestational and estrogenic properties. The effect of this substance on menstrual cycle was studied on 13 healthy fertile women, who received 2 mg of ORG OI-65 daily for 20 consecutive days from the 5th day of cycle. The following parameters were studied  during pretreatment and treatment cycles: bleeding pattern, plasma progesterone, urinary excretion of FSH, LH and estrone, vaginal cytology, cervical mucus, endometrium biopsy and basal body temperature. Treatment with ORG OI-65 did not change the bleeding pattern or inhibit ovulation: all 12 cases with ovulatory pretreatment cycles showed evidence of ovulation--timely or delayed--also during ORG OI-65 treatment. The vaginal cytology and cervical mucus remained almost unaffected by the treatment. No serious side-effects were found. The authors conclude that ORG OI-65 2 mg daily is not effective enough for oral contraception.
D015068:17-Ketosteroids / Q000652:urine*; D000328:Adult; D001831:Body Temperature / Q000187:drug effects; D045166:Estradiol Congeners / Q000494:pharmacology*; D004970:Estrone / Q000652:urine*; D005260:Female; D005640:Follicle Stimulating Hormone / Q000652:urine*; D006801:Humans; D007986:Luteinizing Hormone / Q000652:urine*; D008598:Menstruation / Q000187:drug effects*; D009652:Norpregnenes / Q000494:pharmacology*; D011374:Progesterone / Q000097:blood*; D013997:Time Factors; D014626:Vaginal Smears
D015068:17-Ketosteroids; D045166:Estradiol Congeners; D009652:Norpregnenes; D004970:Estrone; C011578:17 alpha-ethinyl-6-estrene-5 alpha,7 beta-diol; D011374:Progesterone; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone