[Experimental research on the hyperprothrombinemic activity of an isocoumarin derivative: antagonism against anticoagulant dicoumarol (Warfarin)].
In previous research and tests it was found that some isocoumarin derivatives showed marked hyperprothrombinemic activity in rats. This action has now been demonstrated also in rabbits by using one of the most active compounds (allylamide of 4-phenyl-3-isocoumarinic acid). In both species it was found that the drug under test strong by antagonises the anticoagulant action of a dicoumarol compound (Warfarin). This result leads to the supposition that the isocoumarin derivatives tested act in a similar way to Vitamin K.
D000818:Animals; D001777:Blood Coagulation / Q000187:drug effects*; D003374:Coumarins / Q000008:administration & dosage / Q000494:pharmacology*; D008297:Male; D011516:Prothrombin; D011817:Rabbits; D051381:Rats; D014859:Warfarin / Q000037:antagonists & inhibitors*
D003374:Coumarins; D014859:Warfarin; D011516:Prothrombin
Ricerche sperimentali sull'attività iperprotrombinemizzante di un derivato isocumarinico: antagonismo verso un anticoagulante dicumarolico (Warfarin)