Histo-physiological study of hypophysectomized dogs in which the hypophysis was replaced by parotid gland.
This work is an attempt to repeat and confirm the results published by Alvarez-Buylla et al., concerning to hypophysectomy and transplant in salivary gland in dogs. It was found that the survival time was longer in the hypophysectomized-transplanted animals than in those merely hypophysectomized. The 131I uptake by the thyroid of transplanted dogs was lower than by normal dogs, but higher than by the hypophysectomized ones. The histological examination of the hypothalamic-hypophyseal region in both groups of operated animals showed remnants of pars tuberalis cells. The graft of the parotid gland became vascularized exhibiting dilated tubules containing PAS positive granules. An atrophy of thyroid and adrenal glands was also observed. Primordial follicles, follicles in development and cell cords could be found in the ovary of all transplanted animals; in some dogs corpus luteum could also be observed. These results suggest that the transplanted gland in some way provides conditions for the remnant of the hypophyseal cells to perform their function.
D000311:Adrenal Glands / Q000473:pathology / Q000502:physiology; D000818:Animals; D004285:Dogs; D005260:Female; D010306:Parotid Gland / Q000473:pathology / Q000637:transplantation*; D013961:Thyroid Gland / Q000473:pathology / Q000502:physiology; D014182:Transplantation, Autologous