Aortic washout of 125I compounds in atherosclerotic and normal rabbits.
An in vivo rabbit model is described for the study of aortic washout of 125I tagged compounds. Washout is compartmental and in sequence from the lumen, aortic wall, and periaortic fat. Toluene-azo-naphthol (TAN) affixed chiefly to periaortic fat. A double isotope method with TAN plus a cholesterophilic substance is suggested for the assay of atherosclerosis in situ.
D000818:Animals; D001011:Aorta / Q000378:metabolism*; D001161:Arteriosclerosis / Q000175:diagnosis* / Q000378:metabolism; D002784:Cholesterol / Q000302:isolation & purification*; D002791:Cholesterol, Dietary / Q000009:adverse effects; D004195:Disease Models, Animal; D005260:Female; D006801:Humans; D007457:Iodine Radioisotopes; D011817:Rabbits; D014050:Toluene / Q000031:analogs & derivatives
D002791:Cholesterol, Dietary; D007457:Iodine Radioisotopes; D014050:Toluene; D002784:Cholesterol