The influence of alkaline elements on the metabolism of 5-hydroxytryptamine in rat's brain.
A single or four time-administration of Li, Na, K, Rb and Cs chlorides at the doses of 2-5 and 5 mEq/kg ip does not significantly affect 5-HT level. The level of 5-hydroxyindoleacetic acid (5-HIAA) increase only after the administration of LiCl. This increase occurs already after 1 hr and persists up to 24 hrs after the last injection. LiCl given together with probenecid induces the increase in 5-HIAA level greater than that after probenecid alone. The decrease in 5-HIAA level after pargyline-induced inhibition in MAO is more rapid in animals submitted to two action of Li. The increase 5-HIAA level in rat's brain results from Li ions-increased 5-HT turnover.
D000818:Animals; D001921:Brain / Q000378:metabolism*; D002586:Cesium / Q000494:pharmacology; D005260:Female; D006897:Hydroxyindoleacetic Acid / Q000378:metabolism; D008094:Lithium / Q000494:pharmacology; D008297:Male; D008670:Metals / Q000494:pharmacology*; D010293:Pargyline / Q000494:pharmacology; D011188:Potassium / Q000494:pharmacology; D051381:Rats; D012413:Rubidium / Q000494:pharmacology; D012701:Serotonin / Q000378:metabolism*; D012964:Sodium / Q000494:pharmacology
D008670:Metals; D002586:Cesium; D012701:Serotonin; D006897:Hydroxyindoleacetic Acid; D008094:Lithium; D010293:Pargyline; D012964:Sodium; D012413:Rubidium; D011188:Potassium