title: [The mechanism of the diuretic action of chlorazicin].
abstract: Diuretic and natriuretic action of chloracizine in rats was not associated with its direct influence on the kidney and was accompanied by increase in the plasma volume, by a fall of the hematocrite index and of the total plasma proteins. A study of endogenous creatinine and of osmotic-free water clearance showed the diuretic action of chloracizine to be mainly due to the increase of glomerular filtration and to reduction of the relative proximal reabsorption.
mesh_terms: D000818:Animals; D001798:Blood Proteins / Q000032:analysis; D004231:Diuresis / Q000187:drug effects*; D004232:Diuretics / Q000494:pharmacology*; D005919:Glomerular Filtration Rate / Q000187:drug effects; D006400:Hematocrit; D007671:Kidney Concentrating Ability / Q000187:drug effects; D009318:Natriuresis / Q000187:drug effects; D010640:Phenothiazines / Q000494:pharmacology*; D011188:Potassium / Q000652:urine; D051381:Rats; D014665:Vasodilator Agents / Q000494:pharmacology*
chemical_list: D001798:Blood Proteins; D004232:Diuretics; D010640:Phenothiazines; D014665:Vasodilator Agents; D011188:Potassium
vernacular_title: K mekhanizmu diureticheskogo deĭstviia khloratsizina