Studies on human IgD myeloma proteins. Carbohydrate composition of intact proteins and some proteolytic fragments.
Human IgD myeloma proteins are shown to have a high carbohydrate content (9-18%) and to exhibit the same heterogeneity in carbohydrate content and composition as myeloma protein of the other immunoglobulin classes. All IgD proteins studied contain N-acetylgalactosamine which is contained in a carbohydrate moiety attached within the "hinge" region of the heavy chain whilst the bulk of the carbohydrate is attached within the Fcdelta region of the molecule.
D000116:Acetylgalactosamine / Q000032:analysis; D000117:Acetylglucosamine / Q000032:analysis; D002241:Carbohydrates / Q000032:analysis*; D005643:Fucose / Q000032:analysis; D005690:Galactose / Q000032:analysis; D006801:Humans; D007072:Immunoglobulin D / Q000032:analysis*; D007140:Immunoglobulin Fab Fragments; D007141:Immunoglobulin Fc Fragments; D008358:Mannose / Q000032:analysis; D008970:Molecular Weight; D009194:Myeloma Proteins / Q000032:analysis*; D012794:Sialic Acids / Q000032:analysis
D002241:Carbohydrates; D007072:Immunoglobulin D; D007140:Immunoglobulin Fab Fragments; D007141:Immunoglobulin Fc Fragments; D009194:Myeloma Proteins; D012794:Sialic Acids; D005643:Fucose; D000116:Acetylgalactosamine; D008358:Mannose; D000117:Acetylglucosamine; D005690:Galactose