[Isolation of a PIIIcomponent in the electrogram of the frog retina by the use of acetylcholine].
By treating the isolated frog retina with acetylcholine the cornea-positive components in the ERG were suppressed and the cornea-negative component P III resulted as the only response to light stimulation in the mass potential. This P III corresponded in essential features to that P III isolated after treatment with aspartate and known as the mass receptor potential. Therefore, acetylcholine - the postulated transmitter substance between photoreceptors and second retinal neurons - meets the requirement to block the synaptic transmission in this region by artificial excess and to suppress the light evoked generation of the postsynaptic potentials.
D000109:Acetylcholine / Q000494:pharmacology*; D001224:Aspartic Acid / Q000494:pharmacology; D004596:Electroretinography; D010775:Photic Stimulation; D010786:Photoreceptor Cells / Q000187:drug effects; D012160:Retina / Q000502:physiology*; D013569:Synapses
D001224:Aspartic Acid; D000109:Acetylcholine
Isolation einer Komponente P III im Elektrogramm der Froschnetzhaut durch Azetylcholin