title: [Enzymes in urine following administration of hypertonic solutions].
abstract: 3 patients with chronic nephropathies were given 20 ml of a diatrizoate-X-ray contrast medium, 500 ml of a 10% mannitol solution and 500 ml of a 10% dextran solution intravenously, and the behaviour of the excretion of protein, alanine aminopeptidase, beta-glucuronidase, aryl sulphatase A and lysozyme with the urine was tested. After application of these substances a transient increase of the excretion of alanine aminopeptidase, aryl sulphatase A and protein takes place. Conspicuous is the temporary decrease of the beta-glucuronidase activity in the urine after application of these hypertonic solutions. As a common cause of these changes alterations of the tubular cell in the sense of an osmotic nephropathy are to be assumed.
mesh_terms: D000626:Aminopeptidases / Q000652:urine; D001192:Arylsulfatases / Q000652:urine; D003287:Contrast Media; D003404:Creatinine / Q000652:urine; D003911:Dextrans / Q000009:adverse effects*; D004798:Enzymes / Q000652:urine*; D005966:Glucuronidase / Q000652:urine; D006801:Humans; D006982:Hypertonic Solutions; D007676:Kidney Failure, Chronic / Q000000981:diagnostic imaging*; D008353:Mannitol / Q000009:adverse effects*; D011507:Proteinuria / Q000175:diagnosis; D011859:Radiography
chemical_list: D003287:Contrast Media; D003911:Dextrans; D004798:Enzymes; D006982:Hypertonic Solutions; D008353:Mannitol; D003404:Creatinine; D001192:Arylsulfatases; D005966:Glucuronidase; D000626:Aminopeptidases
vernacular_title: Enzyme im Harn nach Applikation hypertoner Lösungen