[Histoxic hypoxia as one of the causes of ventricular fibrillation and decreased myocardial contractility].
Long-lasting infusions of adrenalin were demonstrated to result in histotoxic hypoxy of the myocardium and its decreased contractility. After a preliminary ligation of several branches of the coronary arteries such situations often caused ventricular fibrillation. The restoration of the myocardial contractility and of the oxydation processes was achieved by the administration of Unithiol, Methionin, Cystein and Succimere. The latter often produce an unusual effect--arrest of ventricular fibrillation and restoration of a normal cardiac rhythm without electric defibrillation. The beneficial effect of these drugs is attributed by the authors to the presence of thiol groups in their structure.
D000818:Animals; D002415:Cats; D006321:Heart / Q000503:physiopathology; D000860:Hypoxia / Q000150:complications* / Q000503:physiopathology; D009200:Myocardial Contraction; D009206:Myocardium / Q000378:metabolism; D010084:Oxidation-Reduction; D013438:Sulfhydryl Compounds / Q000627:therapeutic use; D014693:Ventricular Fibrillation / Q000188:drug therapy / Q000209:etiology*
D013438:Sulfhydryl Compounds
Gistotoksicheskaia gipoksiia kak odna iz prichin fibrilliatsii zheludochkov i ponizheniia sokratitel'noĭ sposobnosti miokarda