The Bf locus in the HLA region of chromosome 6: linkage and association studies.
Bf allele frequencies in a material of 172 unrelated Norwegians are given. Bf/HLA linkage relations in 49 informative matings with 178 children, and Bf/HLA association data of a material of 212 Bf-HLA haplotypes are presented. Of 171 informative meioses, there were no Bf-HLA-B recombinations, while 3 out of 158 Bf-HLA-A informative meioses showed recombination. There is significant association between the BfF and the HLA-BW35 allele. It is concluded that the Bf locus is situated on the HLA-B side of HLA-A within the HLA region, in very close proximity to HLA-B.
D000483:Alleles; D002874:Chromosome Mapping; D002906:Chromosomes, Human, 6-12 and X; D003176:Complement C3 / Q000096:biosynthesis; D005787:Gene Frequency; D006680:HLA Antigens; D006649:Histocompatibility Antigens; D006801:Humans; D009664:Norway; D010641:Phenotype; D011995:Recombination, Genetic
D003176:Complement C3; D006680:HLA Antigens; D006649:Histocompatibility Antigens