Pharmacological effects of urotensins. II. Renal effects of urotensin I in the rat.
Urotensin I decreased urine flow, glomerular filtration rate and renal plasma flow in intact and hypophysectomized rats. The antidiuretic effect of urotensin I differed from the that caused by AVT in that (a) the urine conductivity was not usually increased by the former, and (b) the rates of excretion of Na and K were different. The use of hypophysectomized rats and of Na-thioglycollate-treated urotensin I preparations indicated that the antidiuretic effect of urotensin I was not due to the release of endogenous ADH, nor was it caused by presence of AVT in the urotensin I samples.
D000618:Aminohippuric Acids / Q000378:metabolism; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D004231:Diuresis / Q000187:drug effects; D005919:Glomerular Filtration Rate / Q000187:drug effects; D007444:Inulin / Q000378:metabolism; D007668:Kidney / Q000187:drug effects*; D008297:Male; D010455:Peptides / Q000494:pharmacology*; D010902:Pituitary Gland / Q000502:physiology; D011188:Potassium / Q000652:urine; D051381:Rats; D013997:Time Factors
D000618:Aminohippuric Acids; D010455:Peptides; D007444:Inulin; D011188:Potassium