Biological testing of surface-modified acrylic polymers.
The author describes three variants of the surface treatment of PMMA using a special method suggested by Wichterle. Modified surfaces of PMMA discs in three variations A, B, C were followed in subcutaneous implantation in rats during three months and were well tolerated. The final stage was characterized by a stabilized fibrous capsule. The relationship between modified PMMA, glass and pure PMMA in vitro using human and animal blood was also investigated. The author analyzes experiments carried out with human blood (Lee-White's time of blood clotting and fibrin formation after Bürker) and proves better antithrombogenic properties of modified PMMA to control on glass and pure PMMA.
D000179:Acrylates; D000818:Animals; D001777:Blood Coagulation; D004285:Dogs; D005260:Female; D005337:Fibrin / Q000378:metabolism; D005898:Glass; D006801:Humans; D008297:Male; D008689:Methacrylates; D051381:Rats; D013499:Surface Properties; D013997:Time Factors
D000179:Acrylates; D008689:Methacrylates; D005337:Fibrin