[Role of estrogens in phenobarbital induction of microsomal enzymes of the liver].
The action of estradiol dipropionate (250 microgram/kg) and of phenobarbitone-sodium salt (80 microgram/kg) was studied in separate and combined (a single injection of estradiol-dipropionate after a 4-day administration of the phenobarbital-sodium salt) administration. There was an increase in the H3-phenylalanine incorporation into the cell-free protein-synthesizing system by 86% in comparison with control ovariectomized group. Under these conditions estradiol-dipropionate increased the incorporation of the labeled amino acid by 53%. A combined administration of the estrogen and of the barbiturate was not accompanied by the summation of the given effect. There was revealed a correlation between the increase in the rate of the H3-phenylalanine incorporation in vitro and an increase in the content of the cytochrome P-450 in vivo in the microsomes of hepatocytes in separate and combined administration of the preparations. The role of phenobarbitone-sodium salt as an activator of estradiol metabolism in the hepatocytes is discussed.
D000818:Animals; D002369:Castration; D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism; D004357:Drug Synergism; D004790:Enzyme Induction / Q000187:drug effects; D004958:Estradiol / Q000494:pharmacology*; D005260:Female; D008862:Microsomes, Liver / Q000187:drug effects / Q000201:enzymology* / Q000378:metabolism; D010634:Phenobarbital / Q000494:pharmacology*; D010649:Phenylalanine / Q000378:metabolism; D051381:Rats
D010649:Phenylalanine; D004958:Estradiol; D003577:Cytochrome P-450 Enzyme System; D010634:Phenobarbital
Rol' éstrogenov v induktsii fenobarbitalom mikrosomnykh fermentov pecheni