Identification of two related pentapeptides from the brain with potent opiate agonist activity.
Enkephalin, a natural ligand for opiate receptors is composed of the pentapepides H-Tyr-Gly-Gly-Phe-Met-OH and H-Tyr-Gly-Gly-Phe-Leu-OH. The evidence is based on the determination of the amino acid sequence of natural enkephalin by the dansyl-Edman procedure and by mass spectrometry followed by synthesis and comparison of the natural and synthetic peptides.
D000595:Amino Acid Sequence; D000818:Animals; D001921:Brain / Q000378:metabolism; D001923:Brain Chemistry; D008024:Ligands / Q000032:analysis*; D009119:Muscle Contraction / Q000187:drug effects; D009270:Naloxone / Q000494:pharmacology; D009419:Nerve Tissue Proteins / Q000032:analysis* / Q000494:pharmacology; D009842:Oligopeptides / Q000032:analysis* / Q000494:pharmacology; D009892:Opium / Q000378:metabolism*; D011955:Receptors, Drug; D013552:Swine
D008024:Ligands; D009419:Nerve Tissue Proteins; D009842:Oligopeptides; D011955:Receptors, Drug; D009270:Naloxone; D009892:Opium