[Change in cell membrane permeability, and composition and properties of hexokinase during induced carcinogenesis].
The isoenzyme hexokinase (HK) spectrum from normal rat large intestinal mucosa consisted of 3 isoenzymes. In tumours of this localization induced by 1,2-dimethylhydrazine there proved to be a lack or marked decrease in the most rapid anodic isoenzyme. Only one HK isoenzyme was found in the metastases. Km (glucose) for tumour HK was 2--3 times lower than for normal intestinal HK; the HK activity was detected in the serum from the 1st month of the carcinogenic administration, and by the 5th month it was found in 80% of the tumour-bearing animals. No serum HK activity was ever found in control rats.
D000230:Adenocarcinoma / Q000097:blood / Q000139:chemically induced / Q000201:enzymology / Q000473:pathology; D000818:Animals; D002463:Cell Membrane Permeability; D004127:Dimethylhydrazines; D006593:Hexokinase / Q000097:blood / Q000378:metabolism*; D006834:Hydrazines; D007414:Intestinal Neoplasms / Q000097:blood / Q000139:chemically induced* / Q000201:enzymology / Q000473:pathology; D007420:Intestine, Large / Q000201:enzymology / Q000473:pathology; D007527:Isoenzymes / Q000097:blood / Q000378:metabolism; D009362:Neoplasm Metastasis; D009374:Neoplasms, Experimental / Q000097:blood / Q000139:chemically induced / Q000201:enzymology / Q000473:pathology; D051381:Rats
D004127:Dimethylhydrazines; D006834:Hydrazines; D007527:Isoenzymes; D006593:Hexokinase
Izmenenie pronitsaemosti kletochnykh membran, sostava i svoĭstv geksokinazy v protsesse indutsirovannogo kantserogeneza