Further studies on the behavior of 2-mercaptoethanol resistant antibody following cholera vaccinations in a nonendemic country.
Additional data are presented in support of the earlier observation that in nonendemic countries 2-mercaptoethanol (2-ME) resistant vibriocidal antibodies better reflect antibacterial immunity against cholera following vaccination than does total vibriocidal activity. It can be shown that in more than half of the cases even after at least three subsequent vaccinations in six to eight months intervals 2-ME resistant vibriocidins would not last as long as six months. Following intradermal inocculations of vaccine only one in a group of five demonstrated faint 2-ME resistant antibody response. All sera were tested with and without dialysis following 2-ME treatment revealing corresponding results.
D000328:Adult; D000907:Antibodies, Bacterial / Q000032:analysis*; D001770:Blood Bactericidal Activity; D002771:Cholera / Q000453:epidemiology / Q000276:immunology* / Q000517:prevention & control; D006801:Humans; D007271:Injections, Intradermal; D007279:Injections, Subcutaneous; D008623:Mercaptoethanol; D013997:Time Factors; D014611:Vaccination
D000907:Antibodies, Bacterial; D008623:Mercaptoethanol