Response of rat lung to humoral mediators of anaphylaxis and its modification by drugs and sensitization.
1 The effects of humoral mediators of anaphylaxis on the bronchial function of the pithed rat have been assessed and compared with their effects in the guinea-pig and man. 2 5-Hydroxtryptamine, acetylcholine and bradykinin were bronchoconstrictor. Slow reacting substance in anaphylaxis and prostaglandin F2a caused only slight constriction at high doses and histamine was not active. 3 Bradykinin was less active in the rat than in the guinea-pig and its effects were not antagonized by anti-inflammatory analgesic drugs. 4 beta-Adrenoceptor blockade potentiated the activity of bradykinin but not that of 5-hydroxytryptamine or acetylcholine. 5 Dexamethasone reduced the activity of bradykinin but not that of 5-hydroxytryptamine or acetylcholine. 6 Sensitization with Nippostrogylus brasiliensis did not increase the sensitivity of the rat lung to the effects of mediators.
D000109:Acetylcholine / Q000494:pharmacology; D000707:Anaphylaxis / Q000503:physiopathology*; D000818:Animals; D001920:Bradykinin / Q000494:pharmacology; D001980:Bronchi / Q000187:drug effects; D003907:Dexamethasone / Q000494:pharmacology; D006632:Histamine / Q000494:pharmacology; D006967:Hypersensitivity / Q000503:physiopathology*; D008168:Lung / Q000187:drug effects*; D008297:Male; D009559:Nippostrongylus / Q000276:immunology; D011433:Propranolol / Q000494:pharmacology; D011460:Prostaglandins F / Q000494:pharmacology; D051381:Rats; D013189:SRS-A / Q000494:pharmacology; D012701:Serotonin / Q000494:pharmacology; D013045:Species Specificity
D011460:Prostaglandins F; D013189:SRS-A; D012701:Serotonin; D003907:Dexamethasone; D006632:Histamine; D011433:Propranolol; D000109:Acetylcholine; D001920:Bradykinin