The effect of somatostatin on TSH levels in patients with primary hypothyroidism.
Somatostatin, a growth hormone inhibiting factor (GHIF), was infused into 8 patients with primary hypothyroidism at a dosage of 1000 mug for 105 min. GHIF caused a suppression of TSH levels from 42.6 to 76.9% of preinfusion levels with a mean nadir of 65.0 +/- 4.0%;(mean +/- SEM).
D000368:Aged; D006801:Humans; D007037:Hypothyroidism / Q000097:blood / Q000175:diagnosis / Q000503:physiopathology*; D008875:Middle Aged; D010902:Pituitary Gland / Q000503:physiopathology; D013004:Somatostatin; D013972:Thyrotropin / Q000037:antagonists & inhibitors* / Q000097:blood
D013004:Somatostatin; D013972:Thyrotropin