[Common variable immunodeficiency (author's transl)].
In a boy initially diagnosed as X-linked hypogammaglobulinemia, the later clinical and analytical course and the application of new immunological techniques led to the new diagnosis of common variable immunodeficiency. The patient shows panhypogammaglobulinemia, a scarce number of plasma cells with a normal number of precursors and circulating B lymphocytes with membrane bound immunoglobulins and C3 receptors. Delayed hypersensitivity is absent despite normal amount of circulating T lymphocytes which were able to transform when stimulated by PHA. The anergy seems primary and not related to the clinical malnutrition. The authors make a differential diagnosis between both illnesses as a tentative pathogenetic interpretation of B cell development arrest.
D000361:Agammaglobulinemia / Q000151:congenital / Q000175:diagnosis*; D002648:Child; D003937:Diagnosis, Differential; D006801:Humans; D007136:Immunoglobulins / Q000032:analysis; D007153:Immunologic Deficiency Syndromes / Q000175:diagnosis*; D008297:Male; D010375:Pedigree; D012737:Sex Factors
D007136:Immunoglobulins
Síndrome variable común de inmunodeficiencia. Diagnóstico diferencial con la agammaglobulinemia congénita ligada al sexo