Influence of fluorostigmine on some parameters of the catecholaminergic and serotoninergic systems in the mouse brain.
Fluorostigmine (DFP) injected i.p. in doses of 2-45 and 5-0 mg/kg in mice distinctly lowered levels of noradrenaline in the brain, raised levels of dopamine slightly, and very distinctly raised levels of 5-hydroxytryptamine and 5-hydroxyindoleacetic acid. The same dose also weakened MAO activity and diminished oxygen uptake by brain tissue. Drugs which antagonized the above-mentioned changes in the levels of biogenic amine (L-DOPA, PCPA, reserpine) or blocked receptors (phentolamine) only slightly diminished acute toxicity of DFP. On the other hand, a-methyl-p-tyrosine, d,l-tryptophane and nialamide had virtually no effect on acute toxicity.
D000818:Animals; D001921:Brain / Q000187:drug effects / Q000378:metabolism / Q000502:physiology*; D002395:Catecholamines / Q000502:physiology*; D004298:Dopamine / Q000378:metabolism; D007531:Isoflurophate / Q000494:pharmacology*; D008297:Male; D051379:Mice; D008995:Monoamine Oxidase / Q000378:metabolism; D009638:Norepinephrine / Q000378:metabolism; D010101:Oxygen Consumption / Q000187:drug effects; D012701:Serotonin / Q000378:metabolism / Q000502:physiology*
D002395:Catecholamines; D007531:Isoflurophate; D012701:Serotonin; D008995:Monoamine Oxidase; D004298:Dopamine; D009638:Norepinephrine