Sister chromatid exchanges--a sensitive assay of agents damaging human chromosomes.
Sister chromatid exchange frequencies in human lymphocyte chromosomes are greatly increased by alkylating agents, but ionizing radiation has little if any such effect. Scoring these exchanges may provide a useful technique for exploring the mechanisms of chromosome breakage and repair.
D002699:Chlorambucil / Q000494:pharmacology; D002842:Chromatids / Q000502:physiology*; D002869:Chromosome Aberrations; D002875:Chromosomes / Q000528:radiation effects; D005720:Gamma Rays; D006801:Humans; D007621:Karyotyping; D011797:Quinacrine Mustard / Q000494:pharmacology; D011831:Radiation Genetics; D011995:Recombination, Genetic
D002699:Chlorambucil; D011797:Quinacrine Mustard