Gamma-butyrolactone sleep: A 24-hour rhythm paralleling normal sleep in the rat and CNS amine changes.
The duration of sleep induced by a fixed dose of gamma-butyrolactone (GBL) (350 mg/kg, IP) FOllows the normal circadian sleep pattern of rats. GBL sleep duration is maximal at 1800 hr and minimal at 0600 hr. CNS amine changes are not extensive, but when normal sleep is anticipated, GBL treatment increases dopamine and serotonin levels and decreases norepinephrine levels.
D015107:4-Butyrolactone / Q000494:pharmacology*; D000818:Animals; D001921:Brain / Q000378:metabolism*; D001933:Brain Stem / Q000378:metabolism; D002395:Catecholamines / Q000378:metabolism*; D002421:Caudate Nucleus / Q000378:metabolism; D002940:Circadian Rhythm / Q000187:drug effects; D004298:Dopamine / Q000378:metabolism; D005663:Furans / Q000494:pharmacology*; D007031:Hypothalamus / Q000378:metabolism; D008297:Male; D008636:Mesencephalon / Q000378:metabolism; D009638:Norepinephrine / Q000378:metabolism; D051381:Rats; D012701:Serotonin / Q000378:metabolism; D012890:Sleep / Q000187:drug effects*; D013997:Time Factors
D002395:Catecholamines; D005663:Furans; D012701:Serotonin; D015107:4-Butyrolactone; D004298:Dopamine; D009638:Norepinephrine