title: [Pharmacokinetic and chemical investigations in children after oral administration of lidaprim (author's transl)].
abstract: Lidaprim, a new bactericidal combination of trimethoprim and sulfametrol, was administered to 20 patients of a paediatric surgical ward over a period of 7 or more days. Analytic determination of plasma and urine concentrations of the chemotherapeutic agent showed homogeneous drug levels at the chosen dosage. No cumulation was observed. Drug tolerance was excellent. Only one patient developed urticaria when the substance was given together with penicillin, but it was not necessary to stop medication in this case.
mesh_terms: D002648:Child; D002675:Child, Preschool; D004338:Drug Combinations; D004361:Drug Tolerance; D006801:Humans; D007223:Infant; D007239:Infections / Q000188:drug therapy; D013424:Sulfanilamides / Q000097:blood / Q000627:therapeutic use* / Q000652:urine; D014295:Trimethoprim / Q000097:blood / Q000627:therapeutic use* / Q000652:urine
chemical_list: D004338:Drug Combinations; D013424:Sulfanilamides; C011900:lidaprim; D014295:Trimethoprim; C012047:sulfametrole
vernacular_title: Pharmakokinetische und klinisch-chemische Untersuchungen an Kindern nach oraler Gabe von Lidaprim