[Humoral antitumor cytotoxins in patients with melanoma of the skin].
The level of humoral antitumor cytotoxins in sera of malignant melanoma patients has been studied by means of a cytotoxic test in vitro. The authors have shown a cytotoxic effect of sera of most patients on autochthonous tumor cells of melanoma. Hela cells were used as a control cell line. There was no cytotoxic effect of sera (of both melanoma patients and healthy donors) on Hela cells. The patients' sera cross-reacted in allogenic combinations of melanoma target cells and sera. Humoral cytotoxins against melanoma tumor cells have also been found tin sera of healthy donors.
D000903:Antibiotics, Antineoplastic; D003601:Cytotoxicity Tests, Immunologic; D006367:HeLa Cells / Q000276:immunology; D006801:Humans; D008545:Melanoma / Q000276:immunology*; D012878:Skin Neoplasms / Q000276:immunology*
D000903:Antibiotics, Antineoplastic
Gumoral'nye protivoopukholevye tsitotoksiny u bol'nykh melanoblastomoĭ kozhi