Histological Studies in Hodgkin's disease.
200 cases of Hodgkin's disease were found in a revision of the lymph node biopsies studied between 1940 and 1973 at the Institute of Pathology of the Buenos Aires Medical School. Using Rye's nomenclature, 37 (18%) were classified as lymphocytic predominance, 60 (30%) as nodular sclerosis, 81 (41%) as mixed cellularity and 22 (11%) as lymphocyte depletion type of Hodgkin's disease. Preservation of various lymph node structures was observed in 54% of the 200 cases and was more common in the less aggressive varieties of Hodgkin's disease such as lymphocyte predominance and nodular sclerosis. The differences were statistically significant (P less than 001) for the preservation of the medullary sinus and capsule of the lymph node. The presence of sarcoid-like granulomas was more frequent in the lymphocyte predominance type and foam cell areas with Touton giant cells were seen only in cases of nodular sclerosing Hodgkin's disease. Vein invasion was present only in mixed cellularity and lymphocyte depletion hodgkin's disease.
D000328:Adult; D005260:Female; D006689:Hodgkin Disease / Q000145:classification / Q000473:pathology*; D006801:Humans; D008198:Lymph Nodes / Q000473:pathology*; D008214:Lymphocytes / Q000473:pathology; D008264:Macrophages / Q000473:pathology; D008297:Male; D008875:Middle Aged; D012598:Sclerosis; D012737:Sex Factors; D014680:Veins / Q000473:pathology