title: Intravenous tranquillization with ECT.
abstract: Forty depressed in-patients for whom electro-convulsive therapy had been prescribed were rated before treatment on depression and anxiety scales. Side effects, post-operative agitation and retrograde memory impairment were assessed in each patient after each of several treatments. Results were compared when no tranquillizer was given and when either diazepam or haloperidol was administered intravenously immediately before the anaesthetic. It was found than when ECT was given without tranquillization, the incidence and severity of post-operative agitation and of side effects were significantly greater in those patients with a high level of anxiety before treatment. Both diazepam and haloperidol were found to be effective in subduing agitation and side effects in anxious, depressed patients, but with diazepam recovery time was longer.
mesh_terms: D000275:Adjustment Disorders / Q000628:therapy; D000328:Adult; D000368:Aged; D000648:Amnesia, Retrograde / Q000139:chemically induced; D001007:Anxiety / Q000517:prevention & control; D003863:Depression / Q000517:prevention & control / Q000628:therapy; D003975:Diazepam / Q000008:administration & dosage* / Q000009:adverse effects / Q000627:therapeutic use; D004565:Electroconvulsive Therapy / Q000009:adverse effects; D005260:Female; D006220:Haloperidol / Q000008:administration & dosage* / Q000627:therapeutic use; D006801:Humans; D007275:Injections, Intravenous; D008297:Male; D008875:Middle Aged; D011229:Preanesthetic Medication
chemical_list: D006220:Haloperidol; D003975:Diazepam