title: Pharmacological and electrophysiological characteristics of neurones in the paramedian reticular nucleus.
abstract: 1. Neurones in the paramedian reticular nucleus of decerebrate, unanaesthetised cats have been identified by microelectrode recording combined with antidromic activation of their axons in the ipsilateral inferior cerebellar peduncle. Most paramedian reticular neurones were not influenced by somatic stimulation. 2. When applied by iontophoresis from multibarrelled micropipettes acetylcholine and 5-hydroxytryptamine excited all but a few paramedian reticular neurones while l-noradrenaline inhibited almost all the neurones investigated. The excitatory response to acetylcholine could be antagonised by gallamine. 3. The paramedian reticular nucleus appears to be a relatively homogeneous group of neurones, pharmacologically as well as anatomically.
mesh_terms: D000109:Acetylcholine / Q000494:pharmacology; D000200:Action Potentials / Q000187:drug effects; D000818:Animals; D002415:Cats; D002531:Cerebellum / Q000166:cytology; D003655:Decerebrate State; D005260:Female; D008297:Male; D009434:Neural Pathways; D009638:Norepinephrine / Q000494:pharmacology; D012154:Reticular Formation / Q000166:cytology / Q000187:drug effects / Q000502:physiology*; D012701:Serotonin / Q000494:pharmacology
chemical_list: D012701:Serotonin; D000109:Acetylcholine; D009638:Norepinephrine