title: Kininase and anti-inflammatory activities of acid carboxypeptidase from Penicillium janthinellum.
abstract: The acid carboxypeptidase from Penicillium janthinellum catalyzed the rapid release of arginine, and the slow release of phenylalanine, proline, serine and glycine from the carboxy-terminal of bradykinin at pH 4.15 to 4.8. Anti-inflammatory activity of the acid carboxypeptidase seems to suggest that the enzyme hydrolyzed bradykinin in vivo.
mesh_terms: D000596:Amino Acids / Q000378:metabolism; D000818:Animals; D000893:Anti-Inflammatory Agents; D001920:Bradykinin / Q000378:metabolism*; D002268:Carboxypeptidases / Q000378:metabolism* / Q000494:pharmacology; D004487:Edema / Q000188:drug therapy; D006614:Hindlimb; D010407:Penicillium / Q000201:enzymology*; D051381:Rats
chemical_list: D000596:Amino Acids; D000893:Anti-Inflammatory Agents; D002268:Carboxypeptidases; D001920:Bradykinin