An evaluation of apomorphine action on doapminergic receptors.
The controversial literature reports leave open a question whether apomorphine (APO) and dopamine (DA) share a common receptor? After careful evlauation of the arguments, both for and against, about direct action of APO on DA receptor we propose that rigid molecules like APO hold trans-cisoid conformation and preferably interact with the pre-synaptic DA receptors while ADTN (2-amino-6,7-dihydroxy, 1,2,3,4-tetrahydrxonaphthalene) incorporates trans-transcoid conformation and primarily acts on post-synpatic DA receptors. Dopamine, by virtue of its molecular flexibility, can act on both the receptors.
D001058:Apomorphine; D004298:Dopamine; D008968:Molecular Conformation; D009281:Naphthalenes; D011955:Receptors, Drug; D013329:Structure-Activity Relationship; D013569:Synapses; D013764:Tetrahydronaphthalenes
D009281:Naphthalenes; D011955:Receptors, Drug; D013764:Tetrahydronaphthalenes; C011639:ADTN; D001058:Apomorphine; D004298:Dopamine