title: Phosphoglucomutase 3: formal and population genetics and observations on abnormal phenotypes.
abstract: 514 healthy blood donors and 47 families with 122 offspring were studied for phosphoglucomutase 3 (PGM3) from leukocytes. There was a good agreement of allelic frequencies obtained compared to those reported previously in Caucasians. In addition, three individuals with abnormal phenotypes were observed: one was a patient with Hodgkin's disease, the other two were apparently healthy blood donors. In two cases, family members could be studied; none carried the abnormal type of the father. The possible background of these observations with respect to the attachment of the PGM3 locus to the immunogenetic linkage group--the major histocompatibility complex--on chromosome No. 6 in man is discussed.
mesh_terms: D002874:Chromosome Mapping; D004592:Electrophoresis, Starch Gel; D005828:Genetics, Population; D006650:Histocompatibility Testing; D006689:Hodgkin Disease / Q000235:genetics; D006801:Humans; D007125:Immunogenetics; D007527:Isoenzymes / Q000097:blood; D007962:Leukocytes / Q000201:enzymology; D010641:Phenotype; D010733:Phosphoglucomutase / Q000097:blood
chemical_list: D007527:Isoenzymes; D010733:Phosphoglucomutase