Studies on absorption and elimination of drugs. Part VI: Fitting of a double exponential curve to the observed drug concentration after single extravascular administration.
A simple program was written in Algol 1204 for the Polish digital computer ODRA 1204. It permits the fitting of the Bateman equation C equals const [e-KEt -- e-KAt] or the equation C equals Be-KEt -- Ae-KAt to the observed plasma or serum concentration data after single extravascular administration of a drug. The results obtained with this M-31 program, compared with the calculations of the pharmacokinetic parameters for tetracycline HCl obtained with the Wagner's Nonline or Lag Time program, show a good conformity.
D000042:Absorption; D003201:Computers; D007700:Kinetics; D004364:Pharmaceutical Preparations / Q000008:administration & dosage / Q000378:metabolism*; D013752:Tetracycline / Q000378:metabolism
D004364:Pharmaceutical Preparations; D013752:Tetracycline