title: Removal of manganese by chelating agents from brain and liver of manganese treated rats: as in vitro and an in vivo study.
abstract: Some chelating agents were examined for their ability to remove manganese from brain and liver (in vivo) and their sub-cellular fractions (in vitro), of rats pretreated with manganese sulphate. Nitrilotriacetic acid (NTA), 1,2-cyclohexylenedinitrilotetraacetic acid (CDTA) and diethylenetriaminepentaacetic acid (DTPA) were extremely effective in vivo while CDTA and p-aminosalicylic acid (PAS) were efficient in vitro.
mesh_terms: D000818:Animals; D001921:Brain / Q000378:metabolism* / Q000648:ultrastructure; D002614:Chelating Agents / Q000494:pharmacology*; D066298:In Vitro Techniques; D008099:Liver / Q000378:metabolism*; D008297:Male; D008345:Manganese / Q000378:metabolism*; D008928:Mitochondria / Q000187:drug effects / Q000378:metabolism; D008930:Mitochondria, Liver / Q000378:metabolism / Q000648:ultrastructure; D051381:Rats; D013997:Time Factors
chemical_list: D002614:Chelating Agents; D008345:Manganese