GLC determination of procainamide in biological fluids.
A GLC method for the determination of procainamide in biological fluids is presented. By using a dipropyl analog of procainamide as an internal standard, both compounds can be chromatographed directly, yielding linear calibration curves and a sensitivity that allows quantitative determination of concentrations as low as 0.1 mug/ml. The extraction procedure was carefully modified to avoid hydrolysis of N-acetylprocainamide, a major metabolite of procainamide. The usefulness of the procedure is demonstrated by following the disappearance of procainamide from the plasma and urine of human subjects treated with the drug.
D002849:Chromatography, Gas; D006801:Humans; D006868:Hydrolysis; D008722:Methods; D011342:Procainamide / Q000031:analogs & derivatives / Q000032:analysis*
D011342:Procainamide