[Study of acebutolol dialysis and pharmacokinetic data in patients with renal insufficiency undergoing hemodialysis].
The dialysance of acebutolol, in vitro, has been found to be equal to 87 ml/mn for a blood flow of 200 ml/mn through an artificial kidney; at the same flow rate, that of urea is 136 ml/mn. In subjects with normal renal function, half-life of acebutolol in plasma, after oral administration, is 4.4 +/- 0.6 h; in haemodialysed patients with renal failure, it is very increased; during haemodialysis, it is near normal (mean: 5.9 h in 4 subjects). Authors discuss the meaning of acebutolol dialysance, in vivo, considering a possible protein binding of this drug.
D000070:Acebutolol / Q000378:metabolism* / Q000494:pharmacology; D058186:Acute Kidney Injury / Q000378:metabolism*; D006207:Half-Life; D006801:Humans; D006973:Hypertension / Q000378:metabolism; D066298:In Vitro Techniques; D007668:Kidney / Q000378:metabolism; D008657:Metabolic Clearance Rate; D006435:Renal Dialysis
D000070:Acebutolol
Etude de la dialysance de l'acébutolol et données pharmacocinétiques chez l'insuffisant rénal hémodialysé