Enhancement of carrageenin foot oedema by 1,10 -phenanthroline and evidence for the bradykinin as endogenous mediator.
Carrageenin oedema in enhanced by the simultaneous injection in the rat paw of 1,10-phenanthroline, a kininase inhibitor. The analysis of the time-course of this enhancement showed that the maximal effect was observed about 3 hours after the injection. This enhancement was also present when the oedema-producing agent was cellulose sulphate, a kinin-releasing compound. On the contrary, oedema induced by eggwhite as well as by dextran, which are mainly mediated by histamine and 5-hydroxytryptamine, were unaffected by 1,10-phenanthroline. These results further support the role of kinins in the pathogenesis of carrageenin oedema.
D000818:Animals; D001920:Bradykinin / Q000502:physiology*; D002351:Carrageenan; D004357:Drug Synergism; D004487:Edema / Q000139:chemically induced* / Q000378:metabolism / Q000503:physiopathology; D005260:Female; D066298:In Vitro Techniques; D007705:Kinins / Q000378:metabolism / Q000494:pharmacology; D008297:Male; D010618:Phenanthrolines / Q000494:pharmacology*; D011247:Pregnancy; D051381:Rats; D013997:Time Factors; D014590:Uterine Contraction / Q000187:drug effects
D007705:Kinins; D010618:Phenanthrolines; D002351:Carrageenan; D001920:Bradykinin