The effect of chronically administered cannabis extract on the female genital tract of mice and rats.
Daily administration of cannabis extract (mice: 1 mg/day, rats: 5 mg/day for a period of 64 days) results in a cessation of ovarian cyclic activity as judged by vaginal smear and the absence of corpora-lutea in the ovaries of treated rats and mice. Distinct effects are produced upon uterine tissue. Uterine glands were regressed and the stromal edema was conspicuous. Cannabis extract resulted in a decreased uterine RNA, glycogen, and sialic acid concentration. It also brings about a significant depletion in the level of adrenal ascorbic acid.
D000311:Adrenal Glands / Q000187:drug effects; D000818:Animals; D001205:Ascorbic Acid / Q000378:metabolism; D002188:Cannabis / Q000494:pharmacology*; D003338:Corpus Luteum / Q000473:pathology; D005260:Female; D005836:Genitalia, Female / Q000187:drug effects* / Q000378:metabolism; D006003:Glycogen / Q000378:metabolism; D008297:Male; D009929:Organ Size; D010053:Ovary / Q000187:drug effects; D012313:RNA / Q000096:biosynthesis; D051381:Rats; D012794:Sialic Acids / Q000378:metabolism; D013950:Thymus Gland / Q000187:drug effects; D014599:Uterus / Q000187:drug effects; D014621:Vagina / Q000187:drug effects
D012794:Sialic Acids; D012313:RNA; D006003:Glycogen; D001205:Ascorbic Acid