The objective and timing of drug disposition studies, appendix I. Species differences in the tissue distribution of metazimid, an imidazolone derivative.
A marked species difference has been observed in the tissue distribution of metazimid in the rat vs the dog after repeated doses. Differences in toxicity between these species are consistent with tissue levels but not plasma levels. No species differences in patterns of drug metabolism could be found in association with the marked difference in tissue cumulation.
D000818:Animals; D001673:Biodegradation, Environmental; D004285:Dogs; D006207:Half-Life; D007093:Imidazoles / Q000031:analogs & derivatives* / Q000097:blood / Q000378:metabolism; D051381:Rats; D013045:Species Specificity; D013997:Time Factors
D007093:Imidazoles