Preliminary report on the effects of localized head irradiation on the development of transplanted tumors in C3H/HeJ mice.
The growth rate, as measured by increases in volume of a transplanted tumor (adenocarcinoma), was compared in mice that were irradiated locally to the head and in nonirradiated mice. 6-month-old female C3H/HeJ mice were used, and those that were irradiated received dosages of 100 and 200 r from a Keleket 220 KVP 20 Ma X-ray machine. The dosages were delivered at 6.66 r/sec through a 0.25 cu/1.0 aluminium filter. The beam from the X-ray tube was then collimated through a series of lead shields before reaching the cranium of the mouse. 24 h after irradiation, some mice were transplanted into the left side of the axillary fold, with small pieces, approximately 2 mm3, of tumor tissue. Careful weekly examinations for 15 weeks after the initial transplantation revealed major differences in tumor volume between irradiated and nonirradiated animals.
D000230:Adenocarcinoma / Q000276:immunology / Q000473:pathology; D000818:Animals; D005260:Female; D006257:Head / Q000528:radiation effects; D007109:Immunity; D051379:Mice; D008809:Mice, Inbred C3H; D009368:Neoplasm Transplantation; D009374:Neoplasms, Experimental / Q000276:immunology; D011829:Radiation Dosage; D011830:Radiation Effects; D014184:Transplantation, Homologous; D014965:X-Rays