title: The chronic toxicity of methiocarb to grackles, doves, and quail and reproductive effect in quail.
abstract: Methiocarb (4-methylthio-3, 5-xylyl N-methyl carbamate, Mesurol, Bay (3744), a bird repellent, was fed in concentrations of 100 to 1,000 ppm to common grackles (Quiscalus quiscula), mourning doves (Zenaida macroura), and breeding pairs of coturnix quail (Coturnix coturnix) to investigate the possibility of cumulative intoxication. Although aversion to treated diets was readily apparent in most of the tests, the 28- to 30-day median lethal concentration (LC50) was determined to be greater than 100 ppm for grackles, 630 ppm (95% confidence limits, 480-830 ppm) for doves, and greater than 1,000 ppm for coturnix quail. Methiocarb appeared to be noncumulative when measured by an index of chronicity: birds consumed several LD50 doses during a day's feeding, and when deaths occurred, they appeared to be due to acute intoxication. Egg production and live chick production were not affected in coturnix fed 100 ppm but were reduced at 316 and 1,000 ppm.
mesh_terms: D000818:Animals; D001717:Birds / Q000502:physiology*; D001835:Body Weight / Q000187:drug effects; D003370:Coturnix / Q000502:physiology*; D005247:Feeding Behavior / Q000187:drug effects; D005260:Female; D005298:Fertility / Q000187:drug effects; D007306:Insecticides / Q000633:toxicity*; D008297:Male; D008714:Methiocarb / Q000494:pharmacology / Q000633:toxicity*; D011784:Quail / Q000502:physiology*; D012098:Reproduction / Q000187:drug effects*; D013045:Species Specificity
chemical_list: D007306:Insecticides; D008714:Methiocarb