title: Chromosomal abnormalities and dyserythropoiesis in the preleukaemic phase of multiple myeloma.
abstract: Two patients with multiple myeloma and one patient with a plasma-cytoma are reported in whom acute leukaemia developed following long-term treatment with melphalan. Each patient had a complete remission of the plasma cell disorder during which time the bone marrow was moderately to severely hypoplastic. The end of the clinical remission was heralded by a dyserythropoietic anaemia which persisted several months before the emergence of the terminal acute leukaemia. Marked chromosomal abnormalities were observed in marrow cells during the dyserythropoietic phase.
mesh_terms: D001853:Bone Marrow / Q000648:ultrastructure; D001854:Bone Marrow Cells; D002869:Chromosome Aberrations; D002875:Chromosomes / Q000187:drug effects; D004920:Erythropoiesis; D005260:Female; D006801:Humans; D007938:Leukemia / Q000209:etiology*; D008297:Male; D008558:Melphalan / Q000009:adverse effects; D008875:Middle Aged; D009101:Multiple Myeloma / Q000150:complications* / Q000235:genetics / Q000503:physiopathology; D010954:Plasmacytoma / Q000150:complications
chemical_list: D008558:Melphalan