Influence of phospholids on liver damage. I. Carbontetrachloride poisoning and alterations in amino acid uptake, peroxidation, sialic acid content, and lysosomal enzymes.
Changes in peroxidation, amino acid uptake [alpha-amino isobutyrate (AIB)], sialic acid content and lysosomal enzymes were followed in rats after carbon-tetrachloride enzymes were followed in rats after carbontetrachloride poisoning and treatment with phospholipids (EPL). Uptake and retention of AIB by liver and brain increased after CCI4 poisoning. EPL had no effect on these changes. EPL diminished markedly, however, the excessive peroxidation caused by CC14.
D000621:Aminoisobutyric Acids / Q000378:metabolism*; D000818:Animals; D001921:Brain / Q000378:metabolism; D002252:Carbon Tetrachloride Poisoning / Q000378:metabolism*; D056486:Chemical and Drug Induced Liver Injury / Q000378:metabolism*; D005966:Glucuronidase / Q000378:metabolism; D008099:Liver / Q000378:metabolism; D008247:Lysosomes / Q000201:enzymology*; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D010545:Peroxides / Q000378:metabolism*; D010713:Phosphatidylcholines / Q000494:pharmacology*; D051381:Rats; D012794:Sialic Acids / Q000378:metabolism*
D000621:Aminoisobutyric Acids; D010545:Peroxides; D010713:Phosphatidylcholines; D012794:Sialic Acids; D005966:Glucuronidase