Transformation of cell cultures as a parameter for detecting the potential carcinogenicity of antischistosomal drugs.
Several antischistosomal drugs and their metabolites were found to transform rat embryo cell cultures persistently infected with the Rauscher leukemia virus. The transformed cells produced fibrosarcomas when implanted into newborn rats. Cell cultures treated with either virus or chemical alone were not transformed nor were they invasive in rats. The advantages of early screening of developmental drugs in cell culture systems are discussed.
D000818:Animals; D000831:Animals, Newborn; D002273:Carcinogens; D002471:Cell Transformation, Neoplastic / Q000187:drug effects*; D002478:Cells, Cultured; D004622:Embryo, Mammalian; D009368:Neoplasm Transplantation; D051381:Rats; D011919:Rats, Inbred Strains; D011925:Rauscher Virus; D012556:Schistosomicides / Q000494:pharmacology*; D014184:Transplantation, Homologous
D002273:Carcinogens; D012556:Schistosomicides