Immunogenetics of the Lennox-Gastaut syndrome: frequency of HL-A antigens and haplotypes in patients and first-degree relatives.
Twenty-two patients with the Lennox-Gastaut syndrome and their families were examined for HL-A antigens by the microlymphocytotoxicity test. The antigen HL-A7 belonging to the HL-A locus showed a significantly increased frequency (p less than 0.0005) both in parents and in patients. The same antigen showed a significantly altered segregation in patients but a normal one in healthy siblings. Another antigen of the second HL-A locus, HL-A12, did not display a normal segregation in our patients, in whom it was nearly not represented.
D004827:Epilepsy / Q000235:genetics* / Q000276:immunology; D005260:Female; D005787:Gene Frequency; D006680:HLA Antigens / Q000032:analysis*; D006238:Haploidy; D006649:Histocompatibility Antigens / Q000032:analysis*; D006801:Humans; D007125:Immunogenetics; D008297:Male; D010375:Pedigree; D013577:Syndrome
D006680:HLA Antigens; D006649:Histocompatibility Antigens