Genetic counseling of families with Best macular dystrophy.
We have examined 233 members of eight families with BMD. Of these, 169 were also examined with EOG. Sibships wherer greater than or equal to 80% of members were examined clinically and with EOG totaled 39. The results established both the validity and reliability of EOG testing in detecting people genetically affected with BMD. Hyperopia is established as an important manifestation of the disease. The visual prognosis of BMD is described.
D000293:Adolescent; D000328:Adult; D000368:Aged; D002648:Child; D002675:Child, Preschool; D004585:Electrooculography; D005817:Genetic Counseling; D006801:Humans; D006956:Hyperopia / Q000150:complications; D008268:Macular Degeneration / Q000150:complications / Q000235:genetics*; D008875:Middle Aged; D010375:Pedigree; D012162:Retinal Degeneration / Q000235:genetics*; D014792:Visual Acuity