The c 1 fixation and transfer test for studying immunity in melanoma patients.
Sera from 27 melanoma patients and from 30 healthy persons were investigated for humoral immunity by C 1 fixation and transfer test. The number of C 1 molecules fixed to serum treated, sensitized tumor cells and C 1 molecules fixed to these cells in vivo were calculated and the quotient of these values was determined. On the basis of the quotient the patients could be divided into four groups. In Group 1 the serum treatment of cells decreased the C 1 fixation; in these cases the presence of blocking factors can be supposed. In Group 2 the serum treatment did not cause any difference: the patient serum does not contain humoral antibody. In Groups 3 and 4 the C 1 fixation rose slightly and significantly respectively. Work is in progress to find a possible relation of the results with the stage of the disease.
D000912:Antibodies, Neoplasm; D000951:Antigens, Neoplasm; D001667:Binding, Competitive; D003172:Complement C1; D003168:Complement Fixation Tests; D003165:Complement System Proteins; D006801:Humans; D007111:Immunity, Cellular; D009101:Multiple Myeloma / Q000276:immunology*
D000912:Antibodies, Neoplasm; D000951:Antigens, Neoplasm; D003172:Complement C1; D003165:Complement System Proteins