[Treatment of central diabetes insipidus with a combination of chlorpropamide and carbamazepine (author's transl)].
Three patients suffering from central (=neurohormonal) diabetes insipidus were treated with chlorpropamide and carbamazepine simultaneously. This therapy with a combination of the two drugs was based on the aim of getting a good antidiuretic effect when the centrally-stimulating carbamazepine was combined with the peripherally-potentiating chlorpropamide; it was hoped, too, that the side effects of these two drugs, especially the chlorpropamide-induced hypoglycaemia, could be avoided by administration at low dosage. This combined drug therapy proved effective in all three cases: the good antidiuretic effect of chlorpropamide at high dosage is impaired by hypoglycaemia; the combination of carbamazepine allowed the dosage of chlorpropamide to be decreased without impairment of the obtained antidiuretic effect and with avoidance of hypoglycaemia and other side effects. Hence, the combination of chlorpropamide and carbamazepine seems to be recommendable in the treatment of central forms of diabetes insipidus in childhood.
D002220:Carbamazepine / Q000008:administration & dosage / Q000009:adverse effects / Q000494:pharmacology / Q000627:therapeutic use*; D002648:Child; D002747:Chlorpropamide / Q000008:administration & dosage / Q000009:adverse effects / Q000494:pharmacology / Q000627:therapeutic use*; D004231:Diuresis / Q000187:drug effects; D004359:Drug Therapy, Combination; D006801:Humans; D007003:Hypoglycemia / Q000139:chemically induced; D008297:Male; D009994:Osmolar Concentration
D002220:Carbamazepine; D002747:Chlorpropamide
Kombinationstherapie des zentralen Diabetes insipidus mit Chlorpropamid und Carbamazepin