title: Acute lead encephalopathy in the guinea pig.
abstract: Acute lead encephalopathy was induced in adult guinea pigs with daily oral doses of lead carbonate. Cerebral capillaries were examined by electron microscopy, and the blood-brain barrier (B-BB) evaluated with Evans blue and horseradish peroxidase. Brain lead levels were also determined during the developing encephalopathy. There was no cerebral capillary alteration or demonstrable B-BB dysfunction. Brain lead concentrations increased over the 5-day period. The encephalopathy in the absence of any vascular alteration suggests that lead can produce a primary toxic effect at the neuronal level.
mesh_terms: D000818:Animals; D001812:Blood-Brain Barrier / Q000187:drug effects; D001921:Brain / Q000473:pathology*; D001923:Brain Chemistry; D002196:Capillaries / Q000473:pathology; D002560:Cerebrovascular Circulation / Q000187:drug effects; D004195:Disease Models, Animal; D005070:Evans Blue; D006168:Guinea Pigs; D006735:Horseradish Peroxidase / Q000378:metabolism; D007854:Lead / Q000032:analysis; D007855:Lead Poisoning / Q000473:pathology*; D008297:Male; D009474:Neurons / Q000187:drug effects
chemical_list: D007854:Lead; D005070:Evans Blue; D006735:Horseradish Peroxidase