Correction by hyaluronidase of the interstitial tissue transport defect during shock: a new approach to therapy.
We have demonstrated a defect in tissue perfusion during hemorrhagic shock in dogs that is due in part to poor capillary flow, and in part to a defect in interstitial tissue diffusion. Treatment with whole blood alone improves capillary flow but diffusion remains defective. The use of hyaluronidase appears to correct the interstitial diffusion defect observed during shock.
D000818:Animals; D001639:Bicarbonates / Q000097:blood; D001692:Biological Transport / Q000187:drug effects; D001775:Blood Circulation; D001794:Blood Pressure; D002196:Capillaries / Q000187:drug effects; D002245:Carbon Dioxide / Q000097:blood; D004285:Dogs; D005260:Female; D006400:Hematocrit; D006821:Hyaluronoglucosaminidase / Q000494:pharmacology / Q000627:therapeutic use*; D007454:Iodides / Q000378:metabolism; D008099:Liver / Q000378:metabolism*; D008168:Lung / Q000378:metabolism*; D008297:Male; D009132:Muscles / Q000378:metabolism*; D009994:Osmolar Concentration; D010100:Oxygen / Q000097:blood; D012771:Shock, Hemorrhagic / Q000097:blood / Q000188:drug therapy* / Q000378:metabolism; D014978:Xenon / Q000378:metabolism
D001639:Bicarbonates; D007454:Iodides; D002245:Carbon Dioxide; D014978:Xenon; D006821:Hyaluronoglucosaminidase; D010100:Oxygen