title: [Histamine-like stimulator of gastric secretion--3-(beta-aminoethyl)-5-amino-1,2,4-triazole].
abstract: 3-(beta-aminoethyl)-5-amino-1,2,4-triazol or IEM-759 acts predominantly on the histamine H2-receptors in the dog stomach. It produces a lesser effect on the H1-histamine-sensitive receptors of the intestine, vessels and bronchi than histamine. Unlike histalog, IEM-759 taken per os is also effective, this pointing to a possibility of its use in gastoenterology for the assay of secretory capacity of the stomach.
mesh_terms: D000818:Animals; D001625:Betazole / Q000494:pharmacology; D004285:Dogs; D005753:Gastric Mucosa / Q000187:drug effects / Q000378:metabolism*; D006168:Guinea Pigs; D006632:Histamine / Q000378:metabolism / Q000494:pharmacology; D007928:Lethal Dose 50; D011817:Rabbits; D011955:Receptors, Drug / Q000187:drug effects; D014230:Triazoles / Q000494:pharmacology* / Q000633:toxicity
chemical_list: D011955:Receptors, Drug; D014230:Triazoles; D001625:Betazole; D006632:Histamine
vernacular_title: Gistaminopodobnyĭ stimulator zheludochnoĭ sekretsii--3-(beta-aminoétil)-5-amino-1,2,4-triazol