[Metabolism of paraffinic and naphthalenic hydrocarbons in higher animals. I. Retention of paraffins (normal, cyclo and branched) in rats].
Apparent retention of aliphatic hydrocarbons in the Rat is studied. Animals weighing 150 g are put into metabolism cages and given a 15 mg dose of one of the paraffins studied in solution in the peanut oil of the ration. There is no urinary excretion, and fecal elimination is low (5-10%), as long as the carbon chain stays below 24 atoms. Real retention is measured on animals recieving a single dose of 15 mg in the same conditions. Branched paraffins give only very low residual amounts 15 days after ingestion, while n-paraffins and cyclo-paraffins remain unchanged in the carcass, as long as the number of carbon atoms is not greater than 20; the proportion of the latter paraffins is about 8% of the dose ingested (5 days as 21 days after intake). Beyond C 20, real retention decreases rapidly to zero.
D000473:Alkanes / Q000378:metabolism*; D000818:Animals; D001823:Body Composition; D003516:Cycloparaffins / Q000378:metabolism*; D005243:Feces / Q000032:analysis; D005260:Female; D008297:Male; D051381:Rats; D013329:Structure-Activity Relationship
D000473:Alkanes; D003516:Cycloparaffins
Métabolisme des hydrocarbures paraffiniques et naphténiques chez les animaux supérieurs. I. Rétention des paraffines (normal, cyclo et ramifiées) chez le rat