Osteoarticular pains and changes in Wilson's disease: a radiological study in fourteen patients in nine Turkish families.
A series of 14 patients with Wilson's disease were evaluated in order to determine the characteristic bone changes found in this metabolic disorder. The following radiologic and clinical findings deserve to be summarized: (1) Osteoarticular pains as first manifestations of Wilson's disease were found in six patients. (2) In all but 2 of our patients, minor or moderate or even severe bone abnormalities characteristic for Wilson's disease were observed. (3) There were three groups of sibs. Among these sibs, the lesions were not only similar in type but were also acquired approximately at the same time, showing the influence of the different genes responsible for this metabolic disorder.
D000293:Adolescent; D000328:Adult; D001175:Arthrography; D001845:Bone Cysts / Q000209:etiology; D001842:Bone and Bones / Q000000981:diagnostic imaging*; D012080:Chronic Kidney Disease-Mineral and Bone Disorder / Q000209:etiology; D005260:Female; D006527:Hepatolenticular Degeneration / Q000150:complications / Q000000981:diagnostic imaging* / Q000235:genetics; D006801:Humans; D008297:Male; D010024:Osteoporosis / Q000209:etiology; D010146:Pain