title: [Testing of the antirheumatic agent tolmetin for its interactions with oral anticoagulants].
abstract: In 15 patients on long-term oral anticoagulation the new antirheumatic drug tolmetin (Tolectin) was administered over a period of 10 days. Based on 11 parameters of coagulation, no interaction between the drug and phenprocoumon was found. A significant though clinically irrelevant prolongation of bleeding time was observed.
mesh_terms: D000328:Adult; D000368:Aged; D001172:Arthritis, Rheumatoid / Q000188:drug therapy; D001777:Blood Coagulation / Q000187:drug effects; D004347:Drug Interactions; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010644:Phenprocoumon / Q000494:pharmacology; D011758:Pyrroles / Q000494:pharmacology*; D014046:Tolmetin / Q000494:pharmacology* / Q000627:therapeutic use
chemical_list: D011758:Pyrroles; D014046:Tolmetin; D010644:Phenprocoumon
vernacular_title: Prüfung des Antirheumatikums Tolmetin auf Interaktionen mit oralen Antikoagulantien