[The distribution of cholinesterase charged phosphorganic inhibitors and their uncharged analogues in tissues].
The article deals with the hydrophobic character (distribution coefficient in the systems hexane - water and chloroform - water) and certain peculiarities of distributing three cation-containing phosphoroganic inhibitors of cholinesterase and their uncharged analogues in the organisms. The distribution coefficients in the charged and uncharged compounds in the system hexane - water differ inconsiderably, whereas in the system chloroform-water by the thousands and millions times. In rabbits with intravenous administration the content of all inhibitors in blood decreases rapidly, the uncharged compounds accumulate selectively in the lungs and the charged ones are distributed evenly in the tissues.
D000818:Animals; D002800:Cholinesterase Inhibitors / Q000097:blood / Q000378:metabolism*; D008168:Lung / Q000378:metabolism; D009946:Organothiophosphorus Compounds / Q000097:blood / Q000378:metabolism*; D011817:Rabbits; D013329:Structure-Activity Relationship
D002800:Cholinesterase Inhibitors; D009946:Organothiophosphorus Compounds