Lack of protection by pyridoxine or hydrazine pretreatment against monosodium L-glutamate-induced seizures.
Pretreatment of rats with hydrazine (100 mg/kg), a compound which raises brain gamma-aminobutyric acid (GAGA) 175 percent in 12 hr was not able to prevent the occurrence of seizures induced by monosodium L-glutamate (MSG). Pyridoxine (50 mg/kg) the cofactor essential in the conversion of glutamate to GABA, also failed to prevent convulsions induced by parenteral MSG administration. It is concluded that the mechanism of action of MSG-induced seizures is neither by decreasing brain GABA levels or interfering with the pyridoxine cofactor.
D000375:Aging; D000818:Animals; D005260:Female; D005971:Glutamates / Q000009:adverse effects*; D006834:Hydrazines / Q000627:therapeutic use*; D011247:Pregnancy; D011736:Pyridoxine / Q000627:therapeutic use*; D051381:Rats; D012640:Seizures / Q000139:chemically induced / Q000517:prevention & control*; D012970:Sodium Glutamate / Q000009:adverse effects*
D005971:Glutamates; D006834:Hydrazines; D011736:Pyridoxine; D012970:Sodium Glutamate