Sideroblastic anemia with splenic abscess and fatal thromboemboli after splenectomy.
A man with sideroblastic anemia had a splenectomy because of a salmonella abscess of the spleen that had ruptured into the colon. Two months later he developed recurrent thrombophiebitis and fatal thromboembolism associated with thrombocytosis. A review of the literature showed multiple additional cases of sideroblastic anemia with thrombocytosis and thromboembolism after splenectomy. In many of these cases the patient died. Splenectomy for treatment of a sideroblastic anemia probable is contraindicated. If splenectomy is done, long-term therapy to avoid thromboembolic complications probably should be maintained for many months or even years.
D000038:Abscess / Q000150:complications* / Q000601:surgery; D000328:Adult; D000756:Anemia, Sideroblastic / Q000150:complications*; D005268:Femoral Vein; D006801:Humans; D008297:Male; D011655:Pulmonary Embolism / Q000401:mortality; D012480:Salmonella Infections / Q000150:complications* / Q000601:surgery; D013156:Splenectomy / Q000009:adverse effects*; D013158:Splenic Diseases / Q000150:complications* / Q000601:surgery; D013923:Thromboembolism / Q000209:etiology* / Q000401:mortality; D013927:Thrombosis / Q000401:mortality