Pharmacological studies on 1-nitro-9-alkyl acridine derivatives. II. Chronic action.
Encouraging results of preclinical pharmacologic analysis prompted the following study on the chronic action of 1-nitro-9-(diethylaminopropylamino)-acridine (compound C-410) and 1-nitro-9-(diethylaminoethylamino)-acridine (compound C-516). Neither compound had an appreciable effect on quantitative regeneration of peripheral formed blood elements. Liver and kidney function tests were not significantly affectd. Histopathologic studies showed involutive changes in the lymphatic tissues and slight degenerative lesions in parenchymal organs and nuclei. However, these changes were not severe enough to cause functional disturbances or to impair reproductivity.
D000166:Acridines / Q000633:toxicity*; D000818:Animals; D000970:Antineoplastic Agents / Q000633:toxicity*; D003959:Diamines / Q000633:toxicity; D004353:Drug Evaluation, Preclinical; D005029:Ethylenediamines / Q000633:toxicity; D005260:Female; D006321:Heart / Q000187:drug effects; D006413:Hematopoietic System / Q000187:drug effects; D007422:Intestines / Q000187:drug effects; D007668:Kidney / Q000187:drug effects; D008099:Liver / Q000187:drug effects; D008198:Lymph Nodes / Q000187:drug effects; D008297:Male; D011817:Rabbits; D051381:Rats; D013091:Spermatogenesis / Q000187:drug effects; D013997:Time Factors
D000166:Acridines; D000970:Antineoplastic Agents; D003959:Diamines; D005029:Ethylenediamines