Cytolysis of neuraminidase-treated autochthonous lymphoid cells by autologous serum.
Rabbit lymph node cells treated with bacterial neuraminidase become susceptible to cytolysis by autologous antibody and complement. Cytolysis of cells can be prevented by absorbing out the antibodies, probably IgM antibodies, from the autologous serum using neuraminidase-treated autochthonous lymph node cells. The significance of this mechanism is discussed.
D000042:Absorption; D000818:Animals; D001323:Autoantibodies; D003165:Complement System Proteins; D003601:Cytotoxicity Tests, Immunologic; D007075:Immunoglobulin M; D008198:Lymph Nodes / Q000166:cytology / Q000187:drug effects* / Q000276:immunology; D008214:Lymphocytes / Q000276:immunology*; D008297:Male; D009439:Neuraminidase / Q000494:pharmacology*; D011817:Rabbits
D001323:Autoantibodies; D007075:Immunoglobulin M; D003165:Complement System Proteins; D009439:Neuraminidase