[The effect of acetylsalicylic-lysine on platelet function (author's transl)].
Fifteen minutes after the intravenous administration of two different doses of acetylsalicylic lysine, a pronounced inhibition of collagen-induced platelet aggregation was observed in healthy volunteers. A proportionate dose response to the differing doses could not be demonstrated. Platelet function investigated by the glass bead filter method according to Hellem decreased however significantly and dose-dependently after the injections. The clot formation in the thromboelastogram was not disturbed after the administration of the drug in spite of decreased platelet function.
D000328:Adult; D000925:Anticoagulants; D001241:Aspirin / Q000009:adverse effects / Q000031:analogs & derivatives / Q000494:pharmacology*; D003094:Collagen; D004305:Dose-Response Relationship, Drug; D005260:Female; D006801:Humans; D007275:Injections, Intravenous; D008239:Lysine; D008297:Male; D010973:Platelet Adhesiveness / Q000187:drug effects*; D010974:Platelet Aggregation / Q000187:drug effects*; D013916:Thrombelastography
D000925:Anticoagulants; D003094:Collagen; D008239:Lysine; D001241:Aspirin
Die Wirkung von Acetylsalicyl-Lysin auf die Thrombocytenfunktion