[A method of reproduction in mice of chronic sacculated staphylococciasis the deeply tissues].
The intranasal method of infeciton of mice proved to be of no avail in search of a model of prolonged staphylococciasis in animals. Intraorbital infection by Badenski's method - by high staphylococcus doses - produced a severe septico-pyemic process with a high percentage of animal death during the first days of the disease. Intraorbital administration to mice of the pathogenic staphylococci in a dose of 300,000-500,000 microbial cells led to formation (in 60 to 80% cases of the sacculated purulent foci with a preponderant localization of the abscesses in the area of the chest, their prolonged persistance and progressive development. The suggested modification of Badenski's method consisting in the use of a 200 times lower infective dose served as a convenient model for studying the pathogenesis of chronic staphylococcus infection and for testing the therapeutic antistaphylococcus preparations.
D000038:Abscess / Q000209:etiology; D000818:Animals; D002908:Chronic Disease; D004195:Disease Models, Animal; D008100:Liver Abscess / Q000209:etiology; D008169:Lung Abscess / Q000209:etiology; D051379:Mice; D009915:Orbit; D013203:Staphylococcal Infections / Q000209:etiology* / Q000382:microbiology; D013210:Staphylococcus / Q000472:pathogenicity; D013997:Time Factors
Metodika vosproizvedeniia u mysheĭ khronicheskogo osumkovannogo stafilokokkoza glubokolezhashchikh tkaneĭ