[Peculiarities of the development of chloramine induced pulmonary edema in rabbits in various age periods].
Rabbits under three weeks of age were found to be less tolerant to chloramine (CA) than adult rabbits. For them the lethal dose of CA was 40--50 mg/kg. They perished from intoxication with the symptoms of protracted collapse without any manifestations of edema. For older rabbits the lethal dose of CA was 60--70 mg/kg. Death occurred with phenomena of acute and sharp edema of the lungs. In young rabbits atypical edema of the lungs occurred only with the administration of very high doses of CA--200--250 mg/kg. Edematous fluid is present in small amount only; there is a prevalence of hemorrhage, this being possibly caused by a direct alterating action of the CA excreted through the lungs on the walls of the arterioles and capillaries of the vascular system of the lungs.
D000367:Age Factors; D000818:Animals; D002700:Chloramines; D008168:Lung / Q000187:drug effects / Q000473:pathology; D011654:Pulmonary Edema / Q000139:chemically induced* / Q000473:pathology; D011817:Rabbits
D002700:Chloramines
Osobennosti vozniknoveniia khloraminovogo oteka legkikh u krolikov v raznye vozrastnye periody