title: [The role of neuromediators in changes in the character of respiration and in its correction following cranio-cerebral trauma].
abstract: Experimental studies on dogs and clinical examinations of patients with brain injuries permitted to state that the activity of the sympathicoadrenal system in the posttraumatic period is increased. The cholinergic processes in such conditions are inhibited, the concentration of blood serotonin is decreased. Depending upon the character of changed neurohumoral blood factors the parameters of external respiration (hypotachypnoe with respiratory acidosis) are also changed. In such condition hydrocortison fulfills the normalizing effect on the respiratory function only in a stimulation of the inhibited cholinergic system by cholinomimetics.
mesh_terms: D000109:Acetylcholine / Q000097:blood; D000328:Adult; D000818:Animals; D001930:Brain Injuries / Q000188:drug therapy* / Q000378:metabolism / Q000503:physiopathology; D002802:Cholinesterases / Q000097:blood; D004285:Dogs; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D006854:Hydrocortisone / Q000008:administration & dosage / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D010277:Parasympathomimetics / Q000008:administration & dosage / Q000627:therapeutic use*; D012119:Respiration; D012701:Serotonin / Q000097:blood
chemical_list: D010277:Parasympathomimetics; D012701:Serotonin; D002802:Cholinesterases; D000109:Acetylcholine; D006854:Hydrocortisone
vernacular_title: Rol' neĭromediatorov v izmeneniiakh kharaktera dykhaniia i v ego korrektsii pri cherepno-mozgovoĭ travme