Ferrokinetics and erythropoiesis in man: the measurement of effective erythropoiesis, ineffective erythropoiesis and red cell lifespan using 59Fe.
Existing ferrokinetic methods do not provide a direct and quantitative measurement of effective and ineffective red cell production. A new method is described for calculating the daily uptake of iron by maturing red cells and the mean red cell lifespan. Ineffective erythropoiesis and non-erythroid iron turnover are also measured. The method involves standard laboratory techniques but the analysis requires access to a computer. The preliminary results suggest that it will be a clinically useful tool for the investigation of erythroid disorders.
D000740:Anemia / Q000097:blood; D000752:Anemia, Pernicious / Q000097:blood; D004905:Erythrocyte Aging; D004912:Erythrocytes / Q000378:metabolism*; D004920:Erythropoiesis; D006801:Humans; D007501:Iron / Q000097:blood*; D007504:Iron Radioisotopes; D008954:Models, Biological; D010953:Plasma Volume
D007504:Iron Radioisotopes; D007501:Iron