title: Disseminated histoplasmosis due to histoplasma capsulatum in two Nigerian children.
abstract: Two cases of disseminated histoplasmosis caused by H. capsulatum in Nigerian children are reported. This is a rare infection in this part of the world. The main clinical features were fever, weight loss, lassitude, lymphadenopathy, hepatosplenomegaly and severe anaemia, features indistinguishable from those of tuberculosis, Hodgkins and other reticuloses. Recognition of this infection in this environment is possible if it is considered in the differential diagnosis of pyrexia of undetermined origin and appropriate laboratory tests carried out on suitable specimens such as bone marrow, splenic aspirate or biopsy material. Treatment of choice is amphotericin B given intravenously, starting with 0-25 mg/kg. and increasing slowly to 1 mg/kg. Other useful drugs are Septrin and rifampicin which can be given concurrently. Subcutaneous abscesses and multiple bone lesions occurred in both our cases presumably as a result of blood stream infection, or embolisation from endocarditis.
mesh_terms: D000666:Amphotericin B / Q000627:therapeutic use; D002648:Child; D002675:Child, Preschool; D006658:Histoplasma; D006660:Histoplasmosis / Q000175:diagnosis* / Q000188:drug therapy*; D006801:Humans; D008297:Male; D009549:Nigeria; D011239:Prednisolone / Q000627:therapeutic use; D013420:Sulfamethoxazole / Q000627:therapeutic use; D014295:Trimethoprim / Q000627:therapeutic use
chemical_list: D000666:Amphotericin B; D011239:Prednisolone; D014295:Trimethoprim; D013420:Sulfamethoxazole