[Ultrastructure of neurons from the motor region of the cerebral cortex following exposure to lysergamide (LSD) and haloperidol].
The authors describe certain ultrastructural changes in neurons of the cortical motor zone in rats after the administration of haloperidol and LSD in combination with haloperidol. The study took place 1, 4, 8, 12 and 24 hours after the administration of the drugs. LSD caused certain neuron changes --a lucid swelling. An increase in the number of large neurons with a hyperchronic staining of the cytoplasm and an increased intensively stained nuclei was characteristic of haloperidol action. A significant increase of the surface of granular endoplasmatic reticulum and ribosomes was observed in the large hyperchromic neurons. The action of haloperidol on the development of LSD intoxication is regarded as a protective one.
D000818:Animals; D004721:Endoplasmic Reticulum / Q000187:drug effects; D006220:Haloperidol / Q000494:pharmacology*; D008238:Lysergic Acid Diethylamide / Q000494:pharmacology*; D008297:Male; D008854:Microscopy, Electron; D008928:Mitochondria / Q000187:drug effects; D009044:Motor Cortex / Q000187:drug effects* / Q000648:ultrastructure; D051381:Rats; D012270:Ribosomes / Q000187:drug effects
D008238:Lysergic Acid Diethylamide; D006220:Haloperidol
Nekotorye osobennosti ul'trastruktury neĭronov dvigatel'noĭ oblasti kory golovnogo mozga pri vozdeĭstvii lizergamida (LSD) i galoperidola