Influence of quinidine and propranolol on the intracellular distribution of 45Ca in rat heart.
The intracellular distribution of 45Ca in the rat heart was studied following separate and combined administration of quinidine and propranolol. Both drugs caused an increased uptake of 45Ca in the nuclear-cell membrane fraction but quinidine suppressed the uptake in mitochondrial and microsomal fractions whereas propranolol did not affect the uptake of 45Ca in these fractions. In addition, there was an increase in serum radioactivity noted with quinidine which was not observed with propranolol. Combined treatment resulted in restoration of normal values for blood and mitochondrial fractions and an increased uptake of 45Ca in the microsomal fraction.
D000818:Animals; D002118:Calcium / Q000097:blood / Q000378:metabolism*; D002458:Cell Fractionation; D002462:Cell Membrane / Q000378:metabolism; D002467:Cell Nucleus / Q000378:metabolism; D005260:Female; D008861:Microsomes / Q000378:metabolism; D008931:Mitochondria, Muscle / Q000378:metabolism; D009206:Myocardium / Q000378:metabolism*; D011433:Propranolol / Q000494:pharmacology*; D011802:Quinidine / Q000494:pharmacology*; D051381:Rats
D011433:Propranolol; D011802:Quinidine; D002118:Calcium