title: Melanogenesis from topical mechlorethamine and analogues in skin of hairless mice and in vitiligo.
abstract: Progressive repigmentation occurred in vitiliginous skin of two patients topically treated with aqueous solutions of mechlorethamine. Hairless mice were found to provide what seems to be a satisfactory cutaneous system for evaluating potential melanogenic properties of topically applied test compounds.
mesh_terms: D000287:Administration, Topical; D000368:Aged; D000818:Animals; D005260:Female; D006801:Humans; D008297:Male; D008466:Mechlorethamine / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*; D008543:Melanins / Q000096:biosynthesis*; D051379:Mice; D008815:Mice, Inbred Strains; D008875:Middle Aged; D009182:Mycosis Fungoides / Q000188:drug therapy; D012878:Skin Neoplasms / Q000188:drug therapy; D012880:Skin Pigmentation / Q000187:drug effects; D014820:Vitiligo / Q000188:drug therapy*
chemical_list: D008543:Melanins; D008466:Mechlorethamine