[Stimulation of primary immune response by the activation of autoimmune processes].
Experiments were conducted on 220 female mice weighing 20--24 g, with the use of 3 types of antigens (sheep erythrocytes, vaccines from the intestinal and paratyphoid bacilli). There proved to be an increase on the 7th and the 14th day of the formation of specific antibodies under the effect of subcutaneous injection of a homologous blood (0.1--0.3 ml per mouse) 2 hours after the antigen immunization. Hemostimulation not only intensified the antibody-genesis, but also increased the resistance to the infection with the living microbial culture. The stimulating action of the blood injection persisted in irradiation of the mice with gamma-rays in a dose of 300 r. Hemostimulation produced an activation of the normal autoantibody system capable of influencing the function of cells necessary for the antigen assimilation.
D000818:Animals; D000906:Antibodies / Q000032:analysis*; D000917:Antibody Formation / Q000528:radiation effects; D000941:Antigens; D001323:Autoantibodies; D003037:Cobalt Radioisotopes; D004912:Erythrocytes / Q000276:immunology; D005260:Female; D007279:Injections, Subcutaneous; D051379:Mice; D011830:Radiation Effects; D012756:Sheep / Q000276:immunology; D014436:Typhoid-Paratyphoid Vaccines
D000906:Antibodies; D000941:Antigens; D001323:Autoantibodies; D003037:Cobalt Radioisotopes; D014436:Typhoid-Paratyphoid Vaccines
Stimuliatsiia pervichnogo immunnogo otveta putem aktivatsii autoimmunnykh protsessov