Pre- and postnatal toxicity induced in guinea pigs by N-nitrosomethylurea.
Oral administration of N-nitrosomethylurea at maximally tolerated doses to guinea pigs on alternate days from days 34-58 of pregnancy induced prenatal toxicity, as evidenced by a high frequency of stillbirths and intrauterine growth retardation, and postnatal toxicity, as evidenced by stunting and progressive mortality. Similar administration of N-nitrosomethylurethane at maximally tolerated doses did not induce such toxic effects.
D000014:Abnormalities, Drug-Induced / Q000209:etiology*; D000022:Abortion, Spontaneous / Q000139:chemically induced; D000818:Animals; D001724:Birth Weight / Q000187:drug effects; D001996:Bronchopneumonia / Q000139:chemically induced; D005234:Fatty Liver / Q000139:chemically induced; D005260:Female; D005313:Fetal Death / Q000139:chemically induced; D005315:Fetal Diseases / Q000139:chemically induced; D005333:Fetus / Q000187:drug effects*; D006168:Guinea Pigs; D008297:Male; D008770:Methylnitrosourea / Q000009:adverse effects*; D009605:Nitrosomethylurethane / Q000009:adverse effects; D009607:Nitrosourea Compounds / Q000009:adverse effects*; D011247:Pregnancy
D009607:Nitrosourea Compounds; D009605:Nitrosomethylurethane; D008770:Methylnitrosourea