The effect of long-term administration of N-(2-hydroxyethyl)palmitamide on the chemotherapy of RBA rat leukemia.
The effects of N-(2-hydroxyethyl) palmitamide (PEA) a natural and antitoxic substance on the treatment of RBA rat leukemia were studied. Repeated administration of PEA prolonged substantially survival of leukemic animals in the course of the treatment with  cis-diamminedichlor-platinum (cis-Pt(II) in combination with cyclophosphamide, vincristine and methotrexate respectively. The most advantageous combination used was the cis-Pt(II) with methotrexate and PEA administration even improved the treatment results. The long-termed PEA treatment depressed first of all undesirable side effects and enabled to use higher therapeutic dosage of chemotherapeutics and improved the final results.
D000818:Animals; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D002945:Cisplatin / Q000627:therapeutic use; D003520:Cyclophosphamide / Q000627:therapeutic use; D004359:Drug Therapy, Combination; D007942:Leukemia, Experimental / Q000188:drug therapy*; D008727:Methotrexate / Q000627:therapeutic use; D008747:Methylcellulose / Q000627:therapeutic use; D010169:Palmitic Acids / Q000008:administration & dosage / Q000627:therapeutic use*; D051381:Rats; D014750:Vincristine / Q000627:therapeutic use
D000970:Antineoplastic Agents; D010169:Palmitic Acids; D014750:Vincristine; D003520:Cyclophosphamide; D008747:Methylcellulose; D002945:Cisplatin; D008727:Methotrexate