The influence of glucagon on the blood supply of the heart and kidneys in rabbits.
In experiments with rabbits, glucagon prolonged the half-period of absorption of sodium iodide 125J in the left ventricular myocardium. Regitine prevented acceleration of the heart rate and impairment of capillary flow after glucagon. In healthy rabbits hippurate 125J clearance was unaffected by glucagon. After injury of the heart muscle by injection of silver nitrate solution into the left ventricular wall and depression of blood pressure, glucagon partly normalized renal clearance of hippurate 125J.
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D002196:Capillaries / Q000187:drug effects; D003331:Coronary Vessels / Q000187:drug effects*; D005260:Female; D005934:Glucagon / Q000494:pharmacology*; D007454:Iodides / Q000378:metabolism; D007465:Iodohippuric Acid / Q000378:metabolism; D007668:Kidney / Q000098:blood supply*; D008297:Male; D011817:Rabbits; D012039:Regional Blood Flow / Q000187:drug effects; D012835:Silver Nitrate / Q000494:pharmacology
D007454:Iodides; D007465:Iodohippuric Acid; D005934:Glucagon; D012835:Silver Nitrate