title: A method for distinction between RNA and DNA in aldehyde and osmiumtetroxide-fixed electron microscopic autoradiographs.
abstract: A simple method for distinction between RNA- and DNA-containing structures in aldehyde- and osmiumtextroxide-fixed electron microscopic autoradiographs (or ordinary thin sections) is described: the developer and the acetic acid used for processing autoradiographs extract selectively uranium acetate from DNA containing-structures which, after staining with lead citrate, leads to a characteristically 'bleached' appearance of the DNA.
mesh_terms: D000447:Aldehydes; D001345:Autoradiography / Q000379:methods*; D002460:Cell Line; D004247:DNA / Q000032:analysis*; D008854:Microscopy, Electron; D009992:Osmium; D010087:Oxides; D012313:RNA / Q000032:analysis*; D013936:Thymidine / Q000032:analysis
chemical_list: D000447:Aldehydes; D010087:Oxides; D009992:Osmium; D012313:RNA; D004247:DNA; D013936:Thymidine