title: [Substrates and products of fatty acid elongation in mouse brain microsomes].
abstract: In brain microsomes, palmitate and stearate elongation involve a membrane lipid-bound substrate. After elongation by malonyl-CoA, acyl-products are partially bound to proteins. Acyl-proteins are not found when endogenous fatty acid elongation takes place. In the dysmyelinating Quaking mouse mutants, "stearyl-membrane" substrate formation is normal; thus, the deficiency observed in very long chain fatty acid formation is not due to a lack in substrate formation.
mesh_terms: D000818:Animals; D001921:Brain / Q000378:metabolism*; D005227:Fatty Acids / Q000096:biosynthesis*; D008052:Lipid Metabolism, Inborn Errors / Q000378:metabolism; D008055:Lipids / Q000096:biosynthesis*; D008314:Malonates / Q000378:metabolism; D008566:Membranes / Q000378:metabolism; D051379:Mice; D008861:Microsomes / Q000378:metabolism; D009186:Myelin Sheath / Q000378:metabolism; D010169:Palmitic Acids / Q000378:metabolism; D010743:Phospholipids / Q000096:biosynthesis; D013229:Stearic Acids / Q000378:metabolism
chemical_list: D005227:Fatty Acids; D008055:Lipids; D008314:Malonates; D010169:Palmitic Acids; D010743:Phospholipids; D013229:Stearic Acids
vernacular_title: Substrats et produits de l'allongement des acides gras dans les microsomes de cerveaux de souris