[Uptake of serum free fatty acids by lipids of the brown adipose tissue].
The flow rate of serum free fatty acids (FFA) into the lipids of brown adipose tissue (BAT) of newborn rabbits was determined by intravenous injection of [14C]-1-palmitate. For a normal 7 day old animal during acute cold exposure the flow rate is (1 hour in 20 degrees C ambient temperature) 0.209 mumol/minute, that is 3.6% of the serum FFA turnover. Prolonged cold exposure only induced an increase in FFA influx if the lipid depot had been depleted (48 hours starvation in 20 degrees C). Consequently, the BAT takes up serum FFA for heat production only after mobilisation of its lipid stores. It is supposed that the mechanism of the uptake of serum FFA by the BAT is connected with their esterification to triglycerides. The phospholipids of BAT which are not only membrane bound lipids are characterized by a high metabolism.
D002001:Adipose Tissue, Brown / Q000378:metabolism*; D000818:Animals; D001665:Binding Sites; D005230:Fatty Acids, Nonesterified / Q000097:blood / Q000378:metabolism*; D050356:Lipid Metabolism; D008053:Lipid Mobilization; D010743:Phospholipids / Q000378:metabolism; D011817:Rabbits
D005230:Fatty Acids, Nonesterified; D010743:Phospholipids
Aufnahme freier Fettsäuren des Serums in die Lipide des braunen Fettgewebes