[Relationship between the O2-affinity of the blood and erythropoiesis during the early months of life].
In 107 infants aged 3 hours to 9 months, hemoglobin concentration, 2,3-DPG concentration and GOT activity in red cells, and reticulocyte count were determined in order to evaluate whether the previously observed decrease in red cell 2,3-DPG [1] during the first 30-40 days of life related to red cell ageing. A significant positive correlation of 2,3-DPG vs. GOT, an indicator of red cell age, is found. The decrease in 2,3-DPG over a period of 25-30 days is finally followed by a sharp rise in reticulocyte count, suggesting that an alteration in blood oxygen affinity might trigger the onset of erythropoiesis in normal infants in this age group.
D001219:Aspartate Aminotransferases / Q000097:blood; D004163:Diphosphoglyceric Acids / Q000097:blood; D004912:Erythrocytes / Q000201:enzymology; D004920:Erythropoiesis; D005260:Female; D005319:Fetal Hemoglobin / Q000378:metabolism; D006454:Hemoglobins / Q000096:biosynthesis; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D010101:Oxygen Consumption; D011247:Pregnancy
D004163:Diphosphoglyceric Acids; D006454:Hemoglobins; D005319:Fetal Hemoglobin; D001219:Aspartate Aminotransferases
Beziehungen zwischen der O2-Affinität des Blutes und der Erythropoiese in den ersten Lebensmonaten