Tumor suppression by a lymphokine released into the circulation of mice with delayed hypersensitivity.
Lymphokines such as migration inhibitory factor and type II interferon were released into the circulation of tuberculin-sensitive mice after iv injection of old tuberculin. Daily administration of such sera into the tumor sites of mice given implants of sarcoma MC-36 markedly suppressed tumor growth.
D000818:Animals; D005260:Female; D006968:Hypersensitivity, Delayed / Q000276:immunology; D008222:Lymphokines / Q000627:therapeutic use*; D051379:Mice; D008809:Mice, Inbred C3H; D009000:Monocytes / Q000166:cytology; D009368:Neoplasm Transplantation; D012513:Sarcoma, Experimental / Q000276:immunology / Q000473:pathology / Q000628:therapy*
D008222:Lymphokines