title: [Effect of palladium and platinum salts on bacteriophage T4 and its isolated DNA].
abstract: The effect of palladium and platinum salts (K2PdCl4, K2PtCl4) on bacteriophage F4 and its isolated DNA in genetic transformation is investigated. Both compounds efficiently inactivated the phage and decreased the transforming activity of donor DNA. The palladium salt exhibited the higher activity. The palladium compounds inhibited the transforming activity of native donor DNA to a greater degree. No difference was observed in the degree of inactivation of the transforming activity of native and denatured DNA under the effect of platinum salt. It is suggested that the difference in the transforming activity of donor DNA treated with the tested compounds reflect the pattern of their interactions with nucleic acids.
mesh_terms: D003090:Coliphages / Q000187:drug effects*; D004279:DNA, Viral; D010165:Palladium / Q000494:pharmacology*; D010984:Platinum / Q000494:pharmacology*; D014170:Transformation, Genetic / Q000187:drug effects*
chemical_list: D004279:DNA, Viral; D010984:Platinum; D010165:Palladium
vernacular_title: Deĭstvie soleĭ palladiia i platiny na bakteriofag T4 i ego izolirovannuiu DNK