[Hemolytic-uremic syndrome in a young woman following the use of ovulation inhibitors].
After prolonged intake of oral contraceptives a 28-year-old woman developed a hemolytic uremic syndrome with microangiopathic hemolytic anemia, renal failure, malignant hypertension and blindness due to papillary congestion. Renal biopsy revealed widespread arteriolar alterations with massive intimal thickening, narrowing of the lumina and fibrinoid necrosis. During treatment with anticoagulation, antihypertensives and hemodialysis the hemolysis disappeared and vision improved, but the renal failure persisted. The possible relation between oral contraceptives and hemolytic uremic syndrome is mentioned and the literature is reviewed.
D000328:Adult; D001766:Blindness / Q000188:drug therapy / Q000209:etiology; D003000:Clonidine / Q000627:therapeutic use; D003276:Contraceptives, Oral / Q000009:adverse effects*; D003278:Contraceptives, Oral, Hormonal / Q000009:adverse effects*; D003981:Diazoxide / Q000627:therapeutic use; D005260:Female; D006463:Hemolytic-Uremic Syndrome / Q000139:chemically induced* / Q000628:therapy; D006801:Humans; D006974:Hypertension, Malignant / Q000188:drug therapy / Q000209:etiology; D007668:Kidney / Q000473:pathology; D010530:Peritoneal Dialysis; D011241:Prednisone / Q000627:therapeutic use; D011433:Propranolol / Q000627:therapeutic use; D012083:Renin / Q000097:blood
D003276:Contraceptives, Oral; D003278:Contraceptives, Oral, Hormonal; D011433:Propranolol; D012083:Renin; D003000:Clonidine; D003981:Diazoxide; D011241:Prednisone
Hämolytisch-urämisches Syndrom bei einer jungen Frau nach Einnahme von Ovulationshemmern