Central anticholinergic syndrome reversed by tetrahydroaminacrine (tha).
A case of central anticholinergic syndrome after an overdose of orphenadrine citrate (Norflex), treated with tetrahydroaminacrine (THA, Tacrine) is presented. A possible mechanism for the syndrome is discussed in relation to other psychotic states, and the use of anticholinesterase agents in the treatment of toxic psychoses reviewed.
D000166:Acridines / Q000627:therapeutic use*; D000293:Adolescent; D006801:Humans; D009966:Orphenadrine / Q000506:poisoning*; D011605:Psychoses, Substance-Induced / Q000188:drug therapy*; D013577:Syndrome; D013619:Tacrine / Q000627:therapeutic use*
D000166:Acridines; D013619:Tacrine; D009966:Orphenadrine