[Deiodase activity in rats following an overdose of thyroid hormone].
The L-DIT and L-T4 deiodinating activity in supernatants from liver or kidney homogenates of normal rats or rats loaded with T4, T3 or TSH, was investigated. Deiodination of L-DIT occurs in liver supernatants twice as much as in liver, referring to mg of protein of g of tissue, while the deiodination of L-T4 seems rather equal. The over all rate of deiodination, however, reaches in liver for L-DIT the threefold, for L-T4 the fivefold value, as compared with kidney. Short periods of loading do not alter deiodination of L-DIT in liver or kidney at all; but lead to significant elevation of L-T4-deiodination in liver tissue. Higher doses or longer periods of loading cause a significant rise of L-DIT-deiodination in liver and kidney, while the L-T4-deiodination in liver is significantly decreased and in kidney significantly elevated.
D000818:Animals; D001835:Body Weight; D004105:Diiodotyrosine; D066298:In Vitro Techniques; D007453:Iodide Peroxidase / Q000378:metabolism*; D007454:Iodides / Q000378:metabolism; D007668:Kidney / Q000201:enzymology*; D008099:Liver / Q000201:enzymology*; D008297:Male; D009929:Organ Size; D010544:Peroxidases / Q000378:metabolism*; D051381:Rats; D013963:Thyroid Hormones / Q000378:metabolism*; D013974:Thyroxine / Q000008:administration & dosage / Q000378:metabolism; D014284:Triiodothyronine / Q000008:administration & dosage / Q000378:metabolism
D007454:Iodides; D013963:Thyroid Hormones; D014284:Triiodothyronine; D004105:Diiodotyrosine; D010544:Peroxidases; D007453:Iodide Peroxidase; D013974:Thyroxine
Dejodaseaktivität bei Ratten nach Uberangebot an Schilddrüsenhormon.