Conformations and biological properties of apomorphine and its phenanthro(10,1-b,c)azepine homologue.
11,12-Dihydroxy-7-methyl-4,5,6,7,7a,8-hexahydrophenanthro[10,1-b,c]-azepine (2), a homologue of apomorphine (1), has been found to be devoid of dopaminergic effects. The biological differences between apomorphine and this homologue are explained in terms of differences in conformation of the two molecules.
D000818:Animals; D001058:Apomorphine / Q000031:analogs & derivatives* / Q000494:pharmacology*; D004298:Dopamine / Q000494:pharmacology; D051379:Mice; D008968:Molecular Conformation; D051381:Rats; D011955:Receptors, Drug / Q000187:drug effects
D011955:Receptors, Drug; D001058:Apomorphine; D004298:Dopamine