[Distribution of exogenous interferon in experimental animals following intratracheal administration].
The distribution of homologous and heterologous interferon in rabbits after intratracheal administration was studied. The content of interferon in the lung tissue decreased 1 hour after injection. At 3 hours the interferon concentration in the lungs in some animals decreased 2-10-fold as compared with the initial. A considerable reduction in interferon content in the lungs was observed 24 hours post-injection. In the blood serum interferon was found in low titers 1, 3 and 6 hours after intratracheal injection. On the contrary, the amount of interferon in the urine increased beginning at 3-6 hours after injection and up to 24-48 hours.
D000818:Animals; D007267:Injections; D007372:Interferons / Q000097:blood / Q000378:metabolism* / Q000652:urine; D008168:Lung / Q000378:metabolism; D011817:Rabbits; D013997:Time Factors; D014132:Trachea
D007372:Interferons
Raspredelenie ekzogennogo interferona v organizme eksperimental'nykh zhivotnykh pri intratrakheal'nom sposobe vvedeniia