Substituted cycloalkanol ethers of psychostimulant activity: studies on quantitative structure-activity relationships.
Quantitative relationships between chemical structures and locomotor activities of 20 substituted cycloalcanol basic ethers have been investigated using Hansch- and Free-Wilson methods. The Hansch-type regression analysis performed on 10 compounds having different cycloalkyl-rings revealed the highly significant role of the hydrophobic characteristics on the activity tested. The QSAR-study of 20 cycloalcanol-ethers according to Free and Wilson gave a significant equation with good statistical indices. On the basis of the results the compounds under study appear not to exert their activity through interaction with receptor raising strict sterical and electrical requirements.
D000818:Animals; D003516:Cycloparaffins / Q000494:pharmacology; D004987:Ethers / Q000494:pharmacology*; D007700:Kinetics; D051379:Mice; D008968:Molecular Conformation; D009043:Motor Activity / Q000187:drug effects; D011619:Psychotropic Drugs / Q000494:pharmacology*; D012044:Regression Analysis; D013223:Statistics as Topic; D013268:Stimulation, Chemical; D013329:Structure-Activity Relationship
D003516:Cycloparaffins; D004987:Ethers; D011619:Psychotropic Drugs