Individual variation in inosine triphosphate accumulation in human erythrocytes.
Erythrocytes from 5% of a normal population accumulated relatively high amounts of radioactive inosine triphosphate (i.e., greater than 70 nmoles/10(10) cells in 2 hr) when they were incubated with [14C]hypoxanthine. The incidence of this characteristic in a mentally retarded population was 16%. Inosine triphosphate was synthesized from [14C]hypoxanthine, but not from [14C]adenine or [14C]guanine. The metabolism of [14C]adenine and [14C]guanine was the same in erythrocytes that accumulated "normal" and "high" amounts of inosine triphosphate. Inosine triphosphate did not accumulate in leukocytes.
D000225:Adenine / Q000378:metabolism; D000293:Adolescent; D000328:Adult; D002648:Child; D002675:Child, Preschool; D004912:Erythrocytes / Q000378:metabolism*; D005260:Female; D006147:Guanine / Q000378:metabolism; D006801:Humans; D007042:Hypoxanthines / Q000378:metabolism; D007223:Infant; D007292:Inosine Nucleotides / Q000097:blood*; D008607:Intellectual Disability / Q000097:blood*; D007962:Leukocytes / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D011684:Purine Nucleosides / Q000378:metabolism
D007042:Hypoxanthines; D007292:Inosine Nucleotides; D011684:Purine Nucleosides; D006147:Guanine; D000225:Adenine