title: An inhibitory effect of polyphloretin phosphate (PPP) on local anaesthesia.
abstract: In the present investigation it is shown that administration of polyphloretin phosphate (PPP) together with local anaesthetics decreased the duration of infiltration anaesthesia in guinea-pigs. Furthermore, it is shown that in infiltration anaesthesias the local anaesthetic effect was terminated within a few minutes by administration of PPP. In experiments with high- and low-molecular fractions of PPP, the "anti-local anaesthetic" effect of PPP was not due to the antiprostaglandin activity of PPP. There was no effect of PPP on the duration of the nerve-blocking activity of mepivacaine in rats. Neither did the administration of PPP influence the toxic effects of mepivacaine in rabbits.
mesh_terms: D000772:Anesthesia, Local; D000818:Animals; D002045:Bupivacaine / Q000037:antagonists & inhibitors* / Q000378:metabolism; D005260:Female; D006168:Guinea Pigs; D008012:Lidocaine / Q000037:antagonists & inhibitors* / Q000378:metabolism; D008297:Male; D008619:Mepivacaine / Q000037:antagonists & inhibitors* / Q000378:metabolism / Q000633:toxicity; D009407:Nerve Block; D010693:Phloretin / Q000031:analogs & derivatives*; D011121:Polyphloretin Phosphate / Q000494:pharmacology*; D011318:Prilocaine / Q000037:antagonists & inhibitors* / Q000378:metabolism; D011817:Rabbits; D051381:Rats
chemical_list: D011318:Prilocaine; D011121:Polyphloretin Phosphate; D008012:Lidocaine; D008619:Mepivacaine; D010693:Phloretin; D002045:Bupivacaine