[Morphological study of neurovirulence of the Vnukovo-32 strains of rabies virus].
The central nervous system of white mice inoculated with the production Vnukovo-32 strain of tissue culture rabies virus was studied histologically. Intracerebral inoculation resulted in parenchymatous-inflammatory lesions with predominantly severe involvement of the Ammon horn neurons. Subcutaneous inoculations also revealed a rather significant degree of neurovirulence of this strain, although there were definite differences in the pathomorphological pictures observed after inoculation by this and intracerebral route. In mouse experiments the Vnukovo-32 strain showed instability of the properties both with regard to the degree of neurovirulence and to the duration of the incubation period.
D000818:Animals; D001921:Brain / Q000473:pathology*; D006624:Hippocampus / Q000473:pathology; D051379:Mice; D009474:Neurons / Q000166:cytology; D011818:Rabies / Q000473:pathology* / Q000635:transmission; D011820:Rabies virus / Q000254:growth & development / Q000472:pathogenicity*; D014774:Virulence
Morfologicheskoe izuchenie neirovirulentnosti shtamma Vnukovo-32 virusa beshenstva