title: Alkaloids of Vinca rosea L. (Catharanthus roseus G. Don) XXXVI: Isolation and characterization of new dimeric alkaloids.
abstract: In a continuing effort to study thoroughly the alkaloids of Catharanthus roseus, new dimeric alkaloids were isolated and characterized. Structures are proposed for leurocolombine and vinamidine based on UV, IR, PMR, high-resolution mass spectrometry, and CMR. Pseudovincaleukoblastine diol was identified by PMR and mass spectrometry. Leurocolombine exhibited antimitotic activity and marginal antitumor activity against the Ridgeway osteogenic sarcoma.
mesh_terms: D000107:Acetylation; D000818:Animals; D055598:Chemical Phenomena; D002621:Chemistry; D051379:Mice; D008938:Mitosis / Q000187:drug effects; D009374:Neoplasms, Experimental / Q000188:drug therapy; D010084:Oxidation-Reduction; D012509:Sarcoma / Q000188:drug therapy; D014748:Vinca Alkaloids / Q000032:analysis / Q000494:pharmacology / Q000627:therapeutic use
chemical_list: D014748:Vinca Alkaloids