[Effect of polyene antibiotics on plasma membranes of dog kidney].
Effects of amphotericine B and nistatine on plasmatic membranes of dog kidney are studied. Intravenous injection of antibiotics resulted in the change of the chemical composition of plasmatic membranes: the content of proteins, lipids and RNA. The composition of membrane proteins and the quantitative ratio of separate fatty acids in lipids of plasmatic membranes also changed in the presence of amphotericine B and nistatine. It is suggested on the basis of the data obtained that the mechanism of action of polyene antibiotics in dog kidney cells is connected with the damage of membrane structures.
D000666:Amphotericin B / Q000494:pharmacology*; D000818:Animals; D002462:Cell Membrane / Q000187:drug effects / Q000378:metabolism; D004285:Dogs; D007668:Kidney / Q000187:drug effects / Q000378:metabolism*; D050356:Lipid Metabolism; D009761:Nystatin / Q000494:pharmacology*; D011506:Proteins / Q000378:metabolism; D012313:RNA / Q000378:metabolism
D011506:Proteins; D009761:Nystatin; D012313:RNA; D000666:Amphotericin B
Odenístvii polienovykh antibiotikov na plazmaticheskie membrany pochek sobak