Interaction of heart glycosides and phenobarbital.
One week's administration of phenobarbital does not affect the disappearance of a single dose of digitalis glycosides from the serum of man. The increase of bile flow and of liver weight produced by phenobarbital in the rat is not further enhanced by glycosides. In case of acute digitalization, the enzyme inducing effect of barbiturates has probably no clinical significance.
D000293:Adolescent; D000328:Adult; D000368:Aged; D000818:Animals; D001646:Bile / Q000378:metabolism; D004071:Digitalis Glycosides / Q000097:blood / Q000378:metabolism*; D004074:Digitoxin / Q000494:pharmacology; D004347:Drug Interactions; D004790:Enzyme Induction; D005260:Female; D006801:Humans; D008099:Liver / Q000187:drug effects; D008297:Male; D008875:Middle Aged; D009929:Organ Size; D010634:Phenobarbital / Q000494:pharmacology*; D051381:Rats
D004071:Digitalis Glycosides; D004074:Digitoxin; D010634:Phenobarbital