Immunogenic capacity of mouse alloantigens from ischaemic liver.
Immunogenic versus tolerogenic capacity of mouse alloantigens from ischaemic liver was tested in two different congenic strain combinations (H-2 compatible, non-H-2 incompatible). The recipients of test skin allografts were pretreated with tissue homogenate or particulate fraction and the survival pattern of the skin allografts was used as the criterion of the induced status. The results showed a difference in the immunogenicity of antigenic extracts from normal (healthy) and ischaemic liver. Following a single dose, alloantigens from ischaemic liver had an increased immunogenicity (which could be reduced through perfusion) as compared to control (extracts from healthy liver). Following three larger doses of ischaemic liver extracts, the effect was tolerogenic. Possible mechanism of the altered immunogenicity of alloantigens due to ischaemization of the liver tissue and the effect of perfusion are discussed.
D000818:Animals; D000917:Antibody Formation; D006680:HLA Antigens / Q000032:analysis; D007511:Ischemia / Q000276:immunology*; D007519:Isoantigens / Q000032:analysis; D008099:Liver / Q000098:blood supply* / Q000276:immunology; D051379:Mice; D008810:Mice, Inbred C57BL
D006680:HLA Antigens; D007519:Isoantigens