title: Synthesis of morpholinobiguanide derivatives.
abstract: Several new morpholinobiguanide derivatives were synthesized to be tested as hypoglycemic agents, by condensing morpholinobiguanide with alkyl or aryl isocyanate and isothiocyanate, and with dialkylaminoalkyl chloride. The carbamate, prepared from morpholinobiguanide and ethyl chloroformate, was condensed with different aryl amines and certain sulpha drugs. Most of the prepared compounds are easily soluble in water and preliminary examinations as hypoglycemics show promising results.
mesh_terms: D001645:Biguanides / Q000032:analysis / Q000138:chemical synthesis*; D008722:Methods; D009025:Morpholines / Q000032:analysis / Q000138:chemical synthesis
chemical_list: D001645:Biguanides; D009025:Morpholines