Effect of various pharmacological agents on prostaglandin induced increases in microvascular permeability.
The anti-histamines, pyrilamine and chlorpheniramine, the serotonin antagonist, methysergide, the beta-adrenolytic, phenoxybenzamine and the anti-cholinergic, atropine, antagonized the prostaglandin E1 induced increases in vascular permeability. None of the non-steroidal anti-inflammatory agents acted as antagonists at these doses.
D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology; D001285:Atropine / Q000494:pharmacology; D002199:Capillary Permeability / Q000187:drug effects*; D002744:Chlorpheniramine / Q000494:pharmacology; D004837:Epinephrine / Q000494:pharmacology; D007545:Isoproterenol / Q000494:pharmacology; D008297:Male; D008784:Methysergide / Q000494:pharmacology; D010643:Phenoxybenzamine / Q000494:pharmacology; D011453:Prostaglandins / Q000494:pharmacology*; D011458:Prostaglandins E / Q000494:pharmacology; D011460:Prostaglandins F / Q000494:pharmacology; D011738:Pyrilamine / Q000494:pharmacology; D051381:Rats; D013268:Stimulation, Chemical; D014662:Vasoconstrictor Agents / Q000494:pharmacology
D000893:Anti-Inflammatory Agents; D011453:Prostaglandins; D011458:Prostaglandins E; D011460:Prostaglandins F; D014662:Vasoconstrictor Agents; D010643:Phenoxybenzamine; D002744:Chlorpheniramine; D001285:Atropine; D011738:Pyrilamine; D007545:Isoproterenol; D008784:Methysergide; D004837:Epinephrine