[Pharmacology of phthorphenazine-depot].
The psychotropic activity, the content in the organs and tissues, the acute and chronic toxicity of phthorphenazine-depot - (phthorphenazine-decanoate)-2-triphthormethyl-10-/3/1-(beta-caprionyl-oxyethyl)-piperazinyl-4/-propy/phenothiazine - were studied as contrasted against phthorphenazine dehydrochloride. Phthorphenazine-depot has been found to display a prolonged action, a single injection being sufficient to depress conditioned avoidance reflexes for a period of 45-50 days. The antagonism of the drug to phenamine is manifest for 30 days after its administration. After 17 days from the instant of its introduction phthorphenamine is capable of prolonging the anesthetic action of sodium thiopental. Upon a single administration phthorphenazine-depot continues to be in evidence in the tissues of organs and in the blood over a period of 4-5 weeks. The drug is little toxic, this having been ascertained in the course of acute and chronic experiments.
D000661:Amphetamine / Q000037:antagonists & inhibitors; D000818:Animals; D001921:Brain / Q000187:drug effects; D003214:Conditioning, Classical / Q000187:drug effects; D003692:Delayed-Action Preparations; D004357:Drug Synergism; D005476:Fluphenazine / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000494:pharmacology / Q000633:toxicity; D051379:Mice; D051381:Rats; D013874:Thiopental / Q000494:pharmacology; D013997:Time Factors
D003692:Delayed-Action Preparations; D000661:Amphetamine; D013874:Thiopental; D005476:Fluphenazine
K farmakologii ftorfenazina-depo