title: Drusen of the optic disc. A retrospective study in cadaver eyes.
abstract: A retrospective study of 737 consecutive necropsies yielded 15 cases of drusen of the optic nerve head, an incidence of 20-4 cases per thousand. This represents the highest incidence yet reported. The histopathological features of drusen of the nerve head included elevation of the nerve head, compression of optic nerve fibres, partial optic atrophy, cytoid bodies, disc haemorrhages, juxtapapillary retinal scarring with haemosiderin deposition, calcification, and iron deposition within drusen.
mesh_terms: D000328:Adult; D000368:Aged; D002118:Calcium / Q000032:analysis; D005128:Eye Diseases / Q000150:complications / Q000473:pathology; D005260:Female; D006470:Hemorrhage / Q000150:complications; D006485:Hemosiderin / Q000032:analysis; D006801:Humans; D007501:Iron / Q000032:analysis; D008297:Male; D008875:Middle Aged; D009896:Optic Atrophy / Q000473:pathology; D009898:Optic Disk / Q000032:analysis / Q000473:pathology*; D009900:Optic Nerve / Q000473:pathology*; D009901:Optic Nerve Diseases / Q000453:epidemiology / Q000473:pathology; D010857:Pigment Epithelium of Eye / Q000473:pathology; D012160:Retina / Q000473:pathology; D012189:Retrospective Studies
chemical_list: D006485:Hemosiderin; D007501:Iron; D002118:Calcium