Acute effects of carbon monoxide on the metabolism of perfused rat liver.
1. Perfusion of livers with whole blood containing carboxyhaemoglobin decreased hepatic O(2) consumption and triglyceride secretion and raised free fatty acid oxidation. 2. Perfusion with [(14)C]carboxyhaemoglobin indicated that there was negligible hepatic uptake of (14)CO. 3. The observations appear to be due to a decrease in O(2) consumption rather than to specific effects of carboxyhaemoglobin.
D000818:Animals; D002248:Carbon Monoxide / Q000494:pharmacology*; D066298:In Vitro Techniques; D008099:Liver / Q000187:drug effects* / Q000378:metabolism; D008297:Male; D010477:Perfusion; D051381:Rats
D002248:Carbon Monoxide