title: [Regulation of 1-dehydrogenation and 20 beta-reduction of ketosteroids by microorganisms].
abstract: Regulation of two microbiological processes--1-dehydrogenation and 20 beta-reduction of ketosteroids--was studied using several exogeneous quinones which (a) stimulated 1-dehydrogenation and (b) inhibited the accompanying reaction, the reduction of 20-ketogroup of the steroid molecule. The least active compounds were benzoquinones. The best regulators are 1,4-naphthoquinone, 1,2-naphthoquinone, and 7-methoxy-1,2-naphthoquinone. Possible mechanism of the action of naphthoquinones on Mycobacterium globiforme is discussed.
mesh_terms: D003348:Cortisone / Q000378:metabolism; D007664:Ketosteroids / Q000378:metabolism*; D009161:Mycobacterium / Q000187:drug effects / Q000378:metabolism*; D009285:Naphthoquinones / Q000494:pharmacology; D010084:Oxidation-Reduction / Q000187:drug effects; D011241:Prednisone / Q000378:metabolism; D011809:Quinones / Q000494:pharmacology
chemical_list: D007664:Ketosteroids; D009285:Naphthoquinones; D011809:Quinones; D003348:Cortisone; D011241:Prednisone
vernacular_title: Reguliatsiia mikrobiologicheskikh protsessov: 1-degidrogenirovaniia i 20 beta-vosstanovleniia ketosteroidov