Differential effects of alphaMT on anorectic and stimulatory action of amphetamines.
Pretreatment of rats with a dosage regimen of alphaMT that has no effect on the anorectic action of a single dose of 2 mg/kg of d-amphetamine or methamphetamine causes a marked reduction in the rate of continuous avoidance responding evoked by that same dose. Similar pretreatment followed by a dose of 8.0 mg/kg of benzphetamine was without effect on the drug's action on both systems.
D000662:Amphetamines / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D000818:Animals; D001066:Appetite / Q000187:drug effects; D001067:Appetite Depressants; D001362:Avoidance Learning / Q000187:drug effects; D001589:Benzphetamine / Q000494:pharmacology; D001921:Brain / Q000378:metabolism; D001923:Brain Chemistry / Q000187:drug effects; D003913:Dextroamphetamine / Q000494:pharmacology; D004347:Drug Interactions; D008297:Male; D008694:Methamphetamine / Q000494:pharmacology; D008781:Methyltyrosines / Q000494:pharmacology*; D009638:Norepinephrine / Q000378:metabolism; D051381:Rats; D012701:Serotonin / Q000378:metabolism
D000662:Amphetamines; D001067:Appetite Depressants; D008781:Methyltyrosines; D001589:Benzphetamine; D012701:Serotonin; D008694:Methamphetamine; D003913:Dextroamphetamine; D009638:Norepinephrine