title: [Heparin in intravascular coagulation].
abstract: 1. The diagnostic criteria of intravascular coagulation are critically reviewed. Before a potentially dangerous drug is administered, the diagnosis should be more securely established than has been the case in the past. In particular, fibrinogen loss from the circulation must be excluded whenever this protein shows unduly rapid rapid disappearance from the blood. 2. Even when the diagnosis is firmly secured, advocacy of heparin therapy should not be based on theoretical considerations or on the huge amount of accumulated case reports but on figures derived from controlled clinical trials, the essential data being nortality and bleeding complications and not the course of laboratory pattern.
mesh_terms: D000347:Afibrinogenemia / Q000175:diagnosis; D004211:Disseminated Intravascular Coagulation / Q000175:diagnosis / Q000188:drug therapy*; D005338:Fibrin Fibrinogen Degradation Products / Q000032:analysis; D006493:Heparin / Q000627:therapeutic use*; D006801:Humans; D013921:Thrombocytopenia / Q000175:diagnosis
chemical_list: D005338:Fibrin Fibrinogen Degradation Products; D006493:Heparin
vernacular_title: Heparin bei intravasaler Gerinnung