Energy wastage in rats given drugs that induce microsomal enzymes.
Metabolic efficiency was studied in rats given drugs known to induce hepatic microsomal enzymes. The presence of an increased metabolic rate was indicated by increases in oxygen consumption under various experimental conditions and by changes in body weight. The latter was not accounted for by increased losses of energy in excreta. The results support the hypothesis that hepatic microsomal enzyme induction can significantly alter the body's metabolic efficiency.
D000632:Aminopyrine / Q000494:pharmacology; D000818:Animals; D001463:Barbiturates / Q000494:pharmacology*; D001835:Body Weight / Q000187:drug effects; D004734:Energy Metabolism / Q000187:drug effects*; D004790:Enzyme Induction; D000431:Ethanol / Q000494:pharmacology*; D005260:Female; D006591:Hexobarbital / Q000494:pharmacology; D008297:Male; D008862:Microsomes, Liver / Q000187:drug effects / Q000201:enzymology*; D010101:Oxygen Consumption / Q000187:drug effects; D010634:Phenobarbital / Q000494:pharmacology; D051381:Rats
D001463:Barbiturates; D000632:Aminopyrine; D000431:Ethanol; D006591:Hexobarbital; D010634:Phenobarbital