title: [Anatomo-clinical studies and therapeutic results in 2 cases of essential mixed cryoglobulinemia with renal insufficiency].
abstract: Two cases of essential mixed cryoglobulinaemia selected from a personal series on account of their clinical features (hyperviscosity syndrome in one case and frank renal involvement in the other) are presented. Extensive seroimmunological examinations were carried out, along with histopathological studies designed to reveal significant changes in organs and tissues, particularly the skin and kidneys. Reference is briefly made to the debate pathogenesis of the immunological phenomenon that probably lies at the root of the disease. A short account is also given of attempts at treatment with corticosteroids, immunosuppressors and plasmapheresis.
mesh_terms: D000305:Adrenal Cortex Hormones / Q000627:therapeutic use; D000328:Adult; D003450:Cryoglobulins; D005260:Female; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D007676:Kidney Failure, Chronic / Q000150:complications* / Q000188:drug therapy / Q000628:therapy; D008297:Male; D008875:Middle Aged; D010265:Paraproteinemias / Q000150:complications* / Q000188:drug therapy / Q000628:therapy; D010956:Plasmapheresis
chemical_list: D000305:Adrenal Cortex Hormones; D003450:Cryoglobulins; D007166:Immunosuppressive Agents
vernacular_title: Osservazioni anatomo-cliniche e risultati terapeutici in due casi di crioglobulinemia mista essenziale decorrenti con insufficienza renale