The amino acid sequence of the double-headed proteinase inhibitor from canine submandibular glands, III. Sequencing studies.
Canine submandibular glands contain 3 polyvalent, double-headed proteinase inhibitors. The amino acid sequences of the two main inhibitors were determined. They differ only in the substitution of one Lys for a Glu residue. The inhibitor molecules are composed of two halves (domains), one antitryptic and one antichymotryptic. The two domains are covalently linked by 3 amino acid residues. The domains are structurally related to each other and to the sequenced monovalent secretory pancreatic trypsin inhibitors.
D000595:Amino Acid Sequence; D000818:Animals; D001665:Binding Sites; D002918:Chymotrypsin / Q000037:antagonists & inhibitors; D004285:Dogs; D010446:Peptide Fragments / Q000032:analysis; D011480:Protease Inhibitors; D013363:Submandibular Gland / Q000201:enzymology*; D014361:Trypsin Inhibitors / Q000032:analysis
D010446:Peptide Fragments; D011480:Protease Inhibitors; D014361:Trypsin Inhibitors; D002918:Chymotrypsin