Increase in type A virus particles induced in BALB/c mouse epidermis during chemical carcinogenesis.
Electron microscopic observations of normal BALB/c mouse epidermis revealed the presence of isolated intracisternal A particles. Hyperplasia, papilloma and carcinoma formation induced by topical application of the carcinogenic polycyclic hydrocarbons benz(a)pyrene (B(a)P) and 3-methylcholanthrene (MC) is accompanied by an increase in the mumber of A particles. Topical application of a non-carcinogenic irritant alpha-pinene (alpha P) failed to provide comparable changes. Examination of the nuclei indicated occasional electron dense granules in the nucleoplasm which became more common throughout the progression of carcinogenesis.
D000818:Animals; D001580:Benzopyrenes; D002467:Cell Nucleus / Q000648:ultrastructure; D004721:Endoplasmic Reticulum / Q000648:ultrastructure; D008297:Male; D008748:Methylcholanthrene; D051379:Mice; D008807:Mice, Inbred BALB C; D009374:Neoplasms, Experimental / Q000139:chemically induced / Q000382:microbiology; D009858:Oncogenic Viruses / Q000302:isolation & purification*; D010212:Papilloma / Q000139:chemically induced / Q000473:pathology; D012867:Skin / Q000382:microbiology*; D012878:Skin Neoplasms / Q000139:chemically induced / Q000382:microbiology* / Q000473:pathology
D001580:Benzopyrenes; D008748:Methylcholanthrene