title: [Malignant lymphoma following years of hydantoin treatment for epilepsy].
abstract: The cases are presented of 4 hydantreated epileptic patients developing malignant lymphomas (1 Hodgkin's lymphoma). The duration of the hydantoin therapy ranged from 7 to 23 years. There was no evidence of an allergic drug reaction, with the exception of slight blood eosinophilia. Prior to the lymphoma one patient exhibited leukopenia and a second thrombocytopenia. Hydantoins were discontinued in 3 cases but the lymphomas never disappeared spontaneously and only once did tumor progression came to a stillstand. Two patients were successfully treated with either chemo- or radiotherapy. Possible correlations between the documented immunosuppressive action of hydantoin derivatives and tumor induction are discussed. Malignant lymphomas may be sequelae of long-term hydantoin therapy and are not always preceded by the well-known reversible hydantoin lymphadenopathy.
mesh_terms: D004342:Drug Hypersensitivity / Q000276:immunology; D004802:Eosinophilia / Q000276:immunology; D004827:Epilepsy / Q000188:drug therapy*; D006801:Humans; D006827:Hydantoins / Q000009:adverse effects* / Q000627:therapeutic use; D008223:Lymphoma / Q000139:chemically induced* / Q000188:drug therapy / Q000532:radiotherapy
chemical_list: D006827:Hydantoins
vernacular_title: Maligne Lymphome nach jahrelanger Epilepsiebehandlung mit Hydantoinpräparaten