Autoimmune New Zealand mouse. Alterations in C3 receptors, complement-induced clumps and follicular adherence of immune complexes.
Lymphocytes with free complement receptors are markedly diminished in autoimmune mice, probably as a reflection of a receptor blockage by immune complexes. There is also a slight decrease in Fc receptor-bearing cells and an increase in complement-induced clumps. These alterations may be related to a lack of immune complex fixation onto germinal centres and also may play a part in possible defects in T-B-cell co-operation, follicular localization of immune complexes and immune response control in autoimmune mice.
D000818:Animals; D000936:Antigen-Antibody Complex; D001327:Autoimmune Diseases / Q000235:genetics; D003165:Complement System Proteins; D004912:Erythrocytes / Q000276:immunology; D006824:Hybridization, Genetic; D007108:Immune Tolerance; D007141:Immunoglobulin Fc Fragments; D008214:Lymphocytes / Q000276:immunology; D051379:Mice; D008814:Mice, Inbred NZB / Q000276:immunology*; D008815:Mice, Inbred Strains; D013154:Spleen / Q000276:immunology*; D013188:Sri Lanka
D000936:Antigen-Antibody Complex; D007141:Immunoglobulin Fc Fragments; D003165:Complement System Proteins