Hematological alterations and response to acute hypobaric stress.
Exposure of rats to simulated altitude (15,000 ft) for 1 day and 3 and 9 wk produced progressive polycythemia, elevated 2,3-diphosphoglycerate levels and raised P50 values; the latter two parameters decreased toward control values after 9 wk. Carbon monoxide (38-43% HbCO) exposure produced polycythemia after 3- and 9-wk exposure, no change in 2,3-DPG and a fall in P50 value. Ten days' treatment with sodium cyanate produced a large decrease in 2,3-DPG and P50. Survival during 90 min of acute hypobaria (0.3 atm) under Nembutal anesthesia was highest with NaOCN (75%), intermediate with 3- and 9-wk exposure to altitude and CO (56-58%) lower in 1-day altitude exposure (44%) and lowest in controls (5%). Heart and ventilation rate was monitored during this hypobaric test and response patterns established for each exposure/treatment. In states of extreme oxygen deprivation the results suggest, in order of importance, the survival value of 1) increased oxygen-hemoglobin affinity, and 2) polycythemia.
D000531:Altitude; D000818:Animals; D002249:Carbon Monoxide Poisoning / Q000097:blood; D003485:Cyanates / Q000506:poisoning; D004163:Diphosphoglyceric Acids / Q000097:blood; D006339:Heart Rate; D006454:Hemoglobins; D000860:Hypoxia / Q000097:blood*; D008297:Male; D010108:Oxyhemoglobins / Q000032:analysis; D011086:Polycythemia / Q000209:etiology*; D051381:Rats; D012119:Respiration
D003485:Cyanates; D004163:Diphosphoglyceric Acids; D006454:Hemoglobins; D010108:Oxyhemoglobins