[Use of a mathematical model of erythropoiesis to study the recovery process in mice exposed to acute x-ray irradiation].
The model described in the preceding paper was used (after introducing several further presumptions of a radiobiological nature) for the interpretation of the dynamics of erythropoietic recovery, experimentally studied by the authors in mice after acute X-irradiation. The solution of equations in the model was carried out by a digital computer, finding some (not yet experimentally determined) quantitative characteristics of the system by trial and error. A satisfactory degree of agreement in the behaviour of the model with the experimentally determined course of recovery seems to indicate the validity of the basic assumptions of the model, esp. the existence of the negative feedback between erythroid populations of the bone marrow and spleen.
D000818:Animals; D004920:Erythropoiesis; D051379:Mice; D008807:Mice, Inbred BALB C; D008810:Mice, Inbred C57BL; D008954:Models, Biological; D011833:Radiation Injuries, Experimental / Q000503:physiopathology*; D014965:X-Rays
Primenenie matematicheskoĭ modeli éritropoéza dlia issledovaniia protsessa vosstanovleniia posle ostrogo rentgenovskogo oblucheniia u mysheĭ