Glucagon stimulation of hepatic gluconeogenesis in neonatal pigs.
The effect of an infusion of glucagon on gluconeogenesis was studied in 5-day-old piglets. Glucagon stimulated hepatic new glucose formation from lactate, but did not significantly change blood glucose or plasma free fatty acid levels. The data suggest that glucagon enhances substrate flow in the gluconeogenic pathway in neonatal animals.
D000818:Animals; D000831:Animals, Newborn / Q000378:metabolism*; D001786:Blood Glucose / Q000378:metabolism; D005230:Fatty Acids, Nonesterified / Q000097:blood; D005260:Female; D005934:Glucagon / Q000494:pharmacology*; D005943:Gluconeogenesis / Q000187:drug effects*; D007773:Lactates / Q000378:metabolism; D008099:Liver / Q000378:metabolism; D008297:Male; D013268:Stimulation, Chemical; D013552:Swine
D001786:Blood Glucose; D005230:Fatty Acids, Nonesterified; D007773:Lactates; D005934:Glucagon