Absorption, distribution in tissues and routes of excretion of preparation IF-ROM-196 administered to rats orally.
The metabolic fate of a new coronary vasodilating derivative of ethylenediamine (ROM--196) labeled with 14C has been studied in Wistar rats. Dynamics of absorption of the preparation, its distribution in tissues and excretion in urine, feces and bile and expiratory air were investigated. The preparation is quickly absorbed from the gastrointestinal tract and readily penetrates to the tissues. It is excreted mainly in the stools and urine.
D000042:Absorption; D000284:Administration, Oral; D000818:Animals; D005029:Ethylenediamines / Q000008:administration & dosage / Q000378:metabolism*; D005260:Female; D007408:Intestinal Absorption; D007413:Intestinal Mucosa / Q000378:metabolism; D007668:Kidney / Q000378:metabolism; D008099:Liver / Q000378:metabolism; D008297:Male; D009206:Myocardium / Q000378:metabolism; D011412:Propanolamines / Q000008:administration & dosage / Q000378:metabolism*; D051381:Rats
D005029:Ethylenediamines; D011412:Propanolamines; C006063:ROM 196