[[Utero-placental hemodynamics during normal and pathological pregnancies. Its changes under the influence of a beta-sympathicomimetic: salbutamol].
Utero-placental circulation was studied using a gamma-camera which measures the appearance of a radio-active bolus of transferin tagged with Indium 113 in the region of the placenta and of the myometrium. The technique adopted for the calculations that are carried out allows a ratio between the placental blood flow and the myometrial blood flow to be established. The measurements that were taken in the last trimester of pregnancy showed that there was a significant difference between the ratio in normal pregnancies and in those that resulted in the deliveries of small-for-date babies. The foetus is small-for-date in 80 per cent of cases when the placental blood flow (Dp) to the myometrial blood flow (Dm), ratio is less than 80. It is small-for-dates in 25 per cent of cases if the Dp/Dm is between 0.80 and 1.60. If the Dp/Dm ratio is about 1.60 the foetus is normal in 93 per cent of cases. When we compared especially the variations between the Dp/Dm ratio during the administration of Salbutamol, we showed in the light of work already published that the intravenous administration of 50 mug of Salbutamol brought about a lowering of resistance in the placental blood vessels, and probably an increase in the blood flow at the maternal placental site, whereas, on the other hand when 500 mug of Salbutamol were injected intravenously the result was a deficiency in placental blood flow.
D000420:Albuterol / Q000494:pharmacology*; D005260:Female; D006439:Hemodynamics; D006801:Humans; D008431:Maternal-Fetal Exchange / Q000187:drug effects*; D011247:Pregnancy; D011248:Pregnancy Complications / Q000503:physiopathology*
D000420:Albuterol
Hémodynamique utéro-placentaire au dours des grossesses normales et pathologiques. Ses modifications sous l'influence d'un Béta-sympathicomimétique: le salbutamol