Cytogenetic evolution of Ehrlich ascites tumor in rats. A chromosome-banding study.
The injection of Ehrlich tumor cells into normal and immunosuppressed rats induced a transitory ascitic tumor. In an initial stage only Ehrlich metaphases were observed. The incidence of rat metaphases, which appeared later on, increased gradually reaching 100% in a stage when neither the viability nor the tumorigenicity of the Ehrlich cells were significantly modified. No mouse-rat hybrid cells were observed. The results suggest that cell hybridization may be essential for the "naturalization" of a heterologous tumor.
D000818:Animals; D002286:Carcinoma, Ehrlich Tumor / Q000235:genetics*; D002455:Cell Division; D002875:Chromosomes / Q000648:ultrastructure*; D006822:Hybrid Cells / Q000648:ultrastructure; D007621:Karyotyping; D051379:Mice; D009368:Neoplasm Transplantation; D051381:Rats; D014183:Transplantation, Heterologous