Role of the tof gene in the production and perpetuation of the lambdadv plasmid.
A series of lambda derivatives carrying tof mutations were tested for their ability to give rise to plasmid lambda dv. Phages carrying tof mutations that distorted expression of the pRoR-tof-OP operon, were unable to produce lambda dv. Phages carrying an altered tof gene, having only a moderate effect on the same operon, produced unstable lambdadv's. On the other hand, those tof mutants were only the expression of the pLoL-N-exo operon, but not that of the pRoR-tof-OP operon was affected, produced stable lambdadv's.
D003090:Coliphages / Q000378:metabolism*; D004247:DNA / Q000378:metabolism; D004261:DNA Replication; D005111:Extrachromosomal Inheritance; D005838:Genotype; D009154:Mutation; D009876:Operon; D010957:Plasmids; D014158:Transcription, Genetic
D004247:DNA