Hemodynamics and metabolic determinants of distribution of myocardial flow.
A computer simulation of the left coronary outflow response to branch occlusion was carried out, using physiological data derived from canine left coronary artery generated on an IBM 360/44 in order to provide multidimensional analysis of the problem of the distribution of flow within the myocardium. During coronary occlusion in this computer model, distal impedance varied little during the occlusion of one or the other arterial brance. This observation was taken as a boundary condition in the simulation exercise. Some of the important factors in the intramyocardial distribution of flow are discussed.
D000818:Animals; D003201:Computers; D003326:Coronary Circulation; D003327:Coronary Disease / Q000378:metabolism / Q000503:physiopathology*; D004285:Dogs; D006439:Hemodynamics; D008962:Models, Theoretical; D009206:Myocardium / Q000378:metabolism*