[Kinetics of the in vivo synthesis of the polypeptide chain; the effect of translation inhibitors].
Effects of aurinetricarbonic acid and cycloheximide on kinetics of polypeptide chain synthesis and polyribosome protile in mouse liver cell in vivo are studied. Both compounds are found to decrease the absolute rate of protein synthesis and to increase the time of polypeptide synthesis. Cycloheximide changed the ratio of translating and non-translating ribosomes and different in size polyribosome types. Aurinetricarbonic acid exerts no effect on polyribosome profile. Effects of cycloheximide and aurinetricarbonic acid on kinetic parameters of translation and a mechanism of action of these compounds are studied.
D000818:Animals; D001312:Aurintricarboxylic Acid / Q000494:pharmacology*; D003509:Cyclohexanecarboxylic Acids / Q000494:pharmacology*; D003513:Cycloheximide / Q000494:pharmacology*; D007700:Kinetics; D008099:Liver / Q000378:metabolism; D051379:Mice; D010452:Peptide Biosynthesis; D011132:Polyribosomes / Q000187:drug effects* / Q000378:metabolism; D014176:Protein Biosynthesis / Q000187:drug effects*
D003509:Cyclohexanecarboxylic Acids; D001312:Aurintricarboxylic Acid; D003513:Cycloheximide
Kinetika sinteza polipeptidnoi tsepi in vivo: Effekt ingibitorov transliatsii