Distribution and behaviour of isoselenium salts in organism. III. Radioprotective effect of selenium derivatives.
Radioprotective properties of Se-2-aminoethylioselenouronium bromide hydrobromide, 2-aminoselenoazoline and of selenium analogue of mercaptoethylguanidine were followed. Radio-protective effectiveness comparable with classical thiol radioprotectiva was manifested by 2-aminoselenoazoline. In the other two compounds there was on the contrary found a synergism of toxicity and radiation.
D000818:Animals; D003037:Cobalt Radioisotopes; D004305:Dose-Response Relationship, Drug; D004307:Dose-Response Relationship, Radiation; D006146:Guanidines / Q000008:administration & dosage / Q000031:analogs & derivatives / Q000633:toxicity; D007550:Isothiuronium / Q000008:administration & dosage / Q000031:analogs & derivatives / Q000633:toxicity; D051379:Mice; D011833:Radiation Injuries, Experimental / Q000517:prevention & control*; D011837:Radiation-Protective Agents / Q000008:administration & dosage*; D012643:Selenium / Q000008:administration & dosage*; D013329:Structure-Activity Relationship; D013844:Thiazoles / Q000008:administration & dosage / Q000031:analogs & derivatives; D014508:Urea / Q000031:analogs & derivatives* / Q000633:toxicity
D003037:Cobalt Radioisotopes; D006146:Guanidines; D011837:Radiation-Protective Agents; D013844:Thiazoles; D007550:Isothiuronium; D014508:Urea; D012643:Selenium