Melanogenesis from topical mechlorethamine and analogues in skin of hairless mice and in vitiligo.
Progressive repigmentation occurred in vitiliginous skin of two patients topically treated with aqueous solutions of mechlorethamine. Hairless mice were found to provide what seems to be a satisfactory cutaneous system for evaluating potential melanogenic properties of topically applied test compounds.
D000287:Administration, Topical; D000368:Aged; D000818:Animals; D005260:Female; D006801:Humans; D008297:Male; D008466:Mechlorethamine / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*; D008543:Melanins / Q000096:biosynthesis*; D051379:Mice; D008815:Mice, Inbred Strains; D008875:Middle Aged; D009182:Mycosis Fungoides / Q000188:drug therapy; D012878:Skin Neoplasms / Q000188:drug therapy; D012880:Skin Pigmentation / Q000187:drug effects; D014820:Vitiligo / Q000188:drug therapy*
D008543:Melanins; D008466:Mechlorethamine