title: Delayed type allergy in patients with ulcerative colitis. III. Allergic reactions evoked in colonic mucosa by autologous leukocytes and their extracts.
abstract: In 36 patients with ulcerative colitis hypersensitivity reactions induced in the colonic mucosa by autologous leukocytes and their extracts were studied. In 77% of cases reactions developed at the site of leukocyte injection and in 69% of cases at the site of leukocyte extra injection. The time of reaction appearance and the character of histological changes suggest that the reactions were of the cell-mediated type. The results of the investigations indicate that cell-mediated reactions may be an important pathogenic factor in ulcerative colitis.
mesh_terms: D000328:Adult; D000941:Antigens; D003093:Colitis, Ulcerative / Q000209:etiology* / Q000276:immunology / Q000473:pathology; D005260:Female; D006801:Humans; D006968:Hypersensitivity, Delayed / Q000150:complications*; D007111:Immunity, Cellular; D007413:Intestinal Mucosa / Q000276:immunology* / Q000473:pathology; D007420:Intestine, Large / Q000276:immunology; D007962:Leukocytes / Q000276:immunology*; D008297:Male; D008875:Middle Aged
chemical_list: D000941:Antigens