title: [A new approach to the synthesis of enzyme inhibitors].
abstract: On the basis of the application of transition-state theory to enzymatic catalysis a novel approach to the synthesis of inhibitors of enzymes involving conformational rigid substrate has been proposed. It is predicted that the substrates which resemble the natural species in the structure of functional groups, but posses conformational flexibility, will be bound to the enzyme more tightly and converted more slowly than the natural substrate.
mesh_terms: D001665:Binding Sites; D004791:Enzyme Inhibitors / Q000138:chemical synthesis*; D008968:Molecular Conformation; D011485:Protein Binding
chemical_list: D004791:Enzyme Inhibitors
vernacular_title: Novyĭ podkhod k sintezu ingibitorov fermentativnykh reaktsiĭ