[Effects of cyclic AMP and urecholine on gastric secretion in the dog].
The influence of cyclic AMP on gastrin release from the canine antrum was investigated by a direct in vivo method. After removal of spleen, gastric corpus, pancreas and intestine an antral pouch was consecutively perfused with dibutyryl cyclic AMP, papaverin and bethanechol-HCl using a branch of the left gastroepiploic artery. A relevant rise of gastrin in portal blood was only observed during perfusion of bethanechol chloride. Thus cyclic AMP does not release gastrin from the canine antrum.
D000249:Adenosine Monophosphate / Q000494:pharmacology*; D000818:Animals; D001626:Bethanechol Compounds / Q000494:pharmacology*; D003106:Colon / Q000601:surgery; D004285:Dogs; D004386:Duodenum / Q000601:surgery; D005743:Gastrectomy; D005750:Gastric Juice / Q000378:metabolism; D005753:Gastric Mucosa / Q000187:drug effects*; D005755:Gastrins / Q000097:blood / Q000378:metabolism*; D010180:Pancreatectomy; D010208:Papaverine / Q000494:pharmacology; D013156:Splenectomy
D001626:Bethanechol Compounds; D005755:Gastrins; D000249:Adenosine Monophosphate; D010208:Papaverine
Die Wirkung von zyklischem AMP und Urecholine auf die Gastrinausschüttung beim Hund