Cord factor not toxic in rats.
Systemic toxicity and local inflammatory activity of cord factor were compared between mice and rats. In mice, repeated intraperitoneal injection of cord factor caused a marked worsening of general condition and high mortality. The swelling of footpads injected with cord factor was also marked in mice. In contrast, injection of cord factor produced no such toxic reactions in rats, except that repeated intraperitoneal injections of high doses of cord factor induced an accumulation of ascites.
D000818:Animals; D001835:Body Weight / Q000187:drug effects; D003311:Cord Factors / Q000633:toxicity*; D005260:Female; D006017:Glycolipids / Q000633:toxicity*; D008297:Male; D051379:Mice; D008806:Mice, Inbred AKR; D008810:Mice, Inbred C57BL; D008815:Mice, Inbred Strains; D051381:Rats; D013045:Species Specificity
D003311:Cord Factors; D006017:Glycolipids