13-norleucine motilin versus pentagastrin: contrasting and competitive effects on gastrointestinal myoelectrical activity in the conscious dog.
In conscious fasted dogs, with chronically-implanted electrodes in stomach and small intestine, typical aborally-propagated interdigestive myoelectric complexes were induced by the infusion of 13-nor-leucine motilin (13-Nle-M); whereas when the normal interdigestive activity was abolished by the infusion of pentagastrin, the resulting 'postprandial' pattern of activity was not significantly modified by the administration of 13-Nle-M. Results from this study provide further evidence that Motilin as well as Gastrin may be involved in the control of gastrointestinal motility in dogs.
D000818:Animals; D004285:Dogs; D005215:Fasting; D005755:Gastrins / Q000502:physiology; D005768:Gastrointestinal Hormones / Q000494:pharmacology* / Q000502:physiology; D005769:Gastrointestinal Motility / Q000187:drug effects*; D007421:Intestine, Small / Q000187:drug effects; D008564:Membrane Potentials / Q000187:drug effects*; D009130:Muscle, Smooth / Q000187:drug effects; D009646:Norleucine; D010418:Pentagastrin / Q000494:pharmacology*; D010455:Peptides / Q000494:pharmacology; D013270:Stomach / Q000187:drug effects
D005755:Gastrins; D005768:Gastrointestinal Hormones; D010455:Peptides; D009646:Norleucine; D010418:Pentagastrin