[The effect of prolonged treatment of hypertensive rats with antihypertensive drugs of various actions on the arterial tension and noradrenaline level in the myocardium, brain and aortal].
The authors examined the changes in arterial blood pressure and the content of Noradrenaline in the myocardium, brain and aorta of rats with hypertension due to nephrectomy and treatment with desoxycorticosterone and NaCl, and after a chronic 6-month treatment of hypertension with various antihypertensive means. The most significant reduction of noradrenaline in the three of the examined tissues was found in rats, which received dic. sulfyram (100 mg/kg per os). Clondine (10 mkg/kg, per os) manifested the strongest hypotensive effect and lowered the level of noradrenaline in the myocardium, while it was raised in the aorta. Reserpine (10 mkg/kg, s. c) induced a clear reduction of Noradrenaline content in the brain, but an increase in the other two tissues. Insignificant hypotensive effect was observed in animals, treated with guanetidine (0.5 mg/kg, per os), which did not affect substantially noradrenaline in the examined organs. The increase of noradrenaline level was established in the three of the organs of animals, treated with alpha-methyl-DOFA (25 mg/kg, per os). Furosemide (1 mg/kg, s.c.) induced a statistically significant elevation of noradrenaline in the aorta, but was noneffective to noradrenaline in the myocardium and brain.
D000818:Animals; D000959:Antihypertensive Agents / Q000627:therapeutic use*; D001011:Aorta / Q000032:analysis; D001923:Brain Chemistry; D004221:Disulfiram / Q000627:therapeutic use; D005665:Furosemide / Q000627:therapeutic use; D006145:Guanethidine / Q000627:therapeutic use; D006973:Hypertension / Q000188:drug therapy*; D008750:Methyldopa / Q000627:therapeutic use; D009206:Myocardium / Q000032:analysis*; D009638:Norepinephrine / Q000032:analysis*; D051381:Rats; D012110:Reserpine / Q000627:therapeutic use
D000959:Antihypertensive Agents; D008750:Methyldopa; D005665:Furosemide; D012110:Reserpine; D004221:Disulfiram; D009638:Norepinephrine; D006145:Guanethidine
Vliianie na produlzhitelnoto tretirane na khipertonichni plukhove s antikhipertensivni sredstva s razlichen mekhanizum na deĭstvie vurkhu aptepialnogo naliagane i noradrenalinovoto sudurzhanie na miokard mozuk i asrta