Effect of succinylcholine on responses of neurons in the motor cortex to natural activation of muscle spindle primary endings.
In locally anesthetized cats, the effects of intravenous administration of succinylcholine (SCh) in sub-paralytic dosages on the responses of single neurons in motor cortex to small dynamic muscle stretches were studied. A large transient enhancement of these cortical responses with a time course corresponding to the peripheral action of SCh on muscle spindles was observed. This finding is discussed in terms of the hypothesis that muscle spindle primary endings may activate projections to motor cortex.
D000818:Animals; D002415:Cats; D002540:Cerebral Cortex / Q000187:drug effects / Q000502:physiology*; D009119:Muscle Contraction / Q000187:drug effects*; D009474:Neurons / Q000187:drug effects / Q000502:physiology*; D013390:Succinylcholine / Q000494:pharmacology*
D013390:Succinylcholine