[Effect of pregnenolone-16 alpha-carbonitrile on the activity of the rat thyroid gland and anterior pituitary].
PCN, in daily doses of 20 mg/100 g per body weight exerted a marked stimulative effect on the rat thyroid. It was also found that the uptake of radioiodine in animals receiving PCN, was increased. Chromatographic investigations have shown that in PCN treated animals the biosynthesis of thyroid hormones was accelerated. There is evidence of histophysiological activation of the TSH cells of the adenohypophysis. It was concluded that there was no inhibition of the synthesis of thyroid hormones and that activation of the pituitary-thyroid axis under the influence of PCN, resulted from alteration of the peripheral metabolism of thyroxin.
D000818:Animals; D010902:Pituitary Gland / Q000187:drug effects*; D010903:Pituitary Gland, Anterior / Q000187:drug effects*; D011285:Pregnenolone Carbonitrile / Q000494:pharmacology*; D051381:Rats; D013961:Thyroid Gland / Q000187:drug effects*; D013963:Thyroid Hormones / Q000096:biosynthesis; D013972:Thyrotropin / Q000378:metabolism
D013963:Thyroid Hormones; D011285:Pregnenolone Carbonitrile; D013972:Thyrotropin
Effet de la pregnenolone-16 alpha-carbonitrile sur l'activité de la glande thyroïde et l'antéhypophyse du rat