title: Linkage data on MN and the Hb beta locus.
abstract: A sample of 28 informative families was studied for linkage between Hb beta and MN. Values of the neuterized recombination fraction from these and other families from the literature excluded a recombination fraction of less than .30 between these loci. Our results support different recombination values for males and females (theta equals .34 abd .50, respectively). A simple approach to estimate the sample size required as well as a study of the relationship between sibship size and sample size under conditions of loose linkage are also presented.
mesh_terms: D001938:Brazil; D005260:Female; D008040:Genetic Linkage; D005828:Genetics, Population; D006454:Hemoglobins; D006801:Humans; D008951:MNSs Blood-Group System; D008297:Male
chemical_list: D006454:Hemoglobins; D008951:MNSs Blood-Group System