Stimulation of erythropoietic differentiation in BALB/c mice infected with Rauscher leukemia virus.
The function of phenylhydrazine (PHZ) hemolysis in ameliorating the anemia induced in mice by a slow-acting strain of Rauscher leukemia virus (RLV-A) was described. After cessation of treatment with PHZ, mid-stage RLV-A-infected, anemic mice responded with massive reticulocytoses and a rebound in hematocrit above control levels. RLV-infected mice, subjected to PHZ-induced hemolysis or phlebotomy, produced high levels of plasma erythropoietin (Ep); this suggested that Ep mediated the PHZ-induced differentiation. In addition, administration of exogenous Ep induced a wave of erythroid maturation in RLV-infected anemic mice, which indicated that virus-infected erythroid precursors could still respond to the hormone governing normal differentiation.
D000740:Anemia / Q000097:blood / Q000209:etiology* / Q000503:physiopathology; D000818:Animals; D002454:Cell Differentiation / Q000187:drug effects*; D004920:Erythropoiesis / Q000187:drug effects; D004921:Erythropoietin / Q000097:blood / Q000494:pharmacology; D005260:Female; D006400:Hematocrit; D006470:Hemorrhage / Q000097:blood; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D010659:Phenylhydrazines / Q000494:pharmacology*; D011925:Rauscher Virus; D012156:Reticulocytes; D013154:Spleen / Q000502:physiology; D013156:Splenectomy
D010659:Phenylhydrazines; D004921:Erythropoietin