A correlative study of the experimental cardiac dynamics and myocardial energy metabolism.
Relationship between cardiac dynamics and myocardial energy metabolism was studied using dogs treated by isoproterenol, dinitrophenol, propranolol or amobarbital. Isoproterenol changed cardiac dynamic state to positive chronotropism with positive inotropism and myocardial energy liberation to uncoupling of oxidative phosphorylation. Dinitrophenol inducing uncoupling of oxidative phosphorylation, revealed also positive chronotropic and positive inotropic state. Propranolol changed cardiac dynamic state to negative chronotropism with negative inotropism, and myocardial energy liberation to suppression of oxidation. Amobarbital inducing inhibition of intracellular terminal oxidation, revealed also negative chronotropic and negative intropic state. From the above-mentioned results, it might be clear that the positive chronotropism with positive inotropism appears to be relating to the uncoupling of oxidative phosphorylation, as well as the negative chronotropism with negative inotropism to the suppression of mitochondrial respiration.
D000654:Amobarbital / Q000494:pharmacology; D000818:Animals; D004285:Dogs; D006339:Heart Rate / Q000187:drug effects; D008931:Mitochondria, Muscle / Q000378:metabolism*; D009200:Myocardial Contraction / Q000187:drug effects; D010085:Oxidative Phosphorylation / Q000187:drug effects; D010101:Oxygen Consumption / Q000187:drug effects; D011433:Propranolol / Q000494:pharmacology
D011433:Propranolol; D000654:Amobarbital