title: Experimental and clinical studies of 5-fluorocytosine activity in candida ocular infections, II. The effect of 5-fluorocytosine in treating experimental candida infection in rabbits' eyes.
abstract: Mild and severe experimental ocular infections in rabbits' eyes were induced by inoculation of Candida albicans with or without addition of dexamycin drops. These rabbits were treated with 5-Fluorocytosine, topically, orally and in a combined topical and oral manner. The topical treatment was effective only in mild infections. Severe infections responded to oral and especially to combined oral-tropical treatment.
mesh_terms: D000284:Administration, Oral; D000287:Administration, Topical; D000818:Animals; D002177:Candidiasis / Q000188:drug therapy*; D003596:Cytosine / Q000031:analogs & derivatives*; D005128:Eye Diseases / Q000188:drug therapy*; D005437:Flucytosine / Q000008:administration & dosage / Q000627:therapeutic use*; D011817:Rabbits
chemical_list: D003596:Cytosine; D005437:Flucytosine