title: Linkage studies between HL-A and GPT polymorphisms and other genetic markers.
abstract: The phenotypes of 56 families with 126 children from the Hamburg area as well as gene frequencies and segregation of the genetic markers GPT, AP, ADA, AK, PGM1, PGM3, 6-PGD, CHE, C3, Gc, Tf, Hp and Cp were studied. In regard to linkage, the informative families were correlated to the results of HL-A and GPT typing. The linkage was tested according to the sequential test by MORTON (1955). See article. For other gene loci, linkage to the HL-A or GPT system could not be proved. But the positive lod scores of HL-A/GPT, HL-A/AP and GPT/6-PGD may give indication for linkage.
mesh_terms: D000410:Alanine Transaminase; D005260:Female; D005787:Gene Frequency; D005796:Genes; D008040:Genetic Linkage; D006680:HLA Antigens; D006649:Histocompatibility Antigens; D006801:Humans; D008297:Male; D011110:Polymorphism, Genetic; D011995:Recombination, Genetic
chemical_list: D006680:HLA Antigens; D006649:Histocompatibility Antigens; D000410:Alanine Transaminase