[Animal experiments on the "dysionic genesis of intrauterine malformations"].
Pregnant rabbits were injected 12 mg 4-chloro-5-sulfamoyl-N-furfuryl-anthranilic acid (furosemide)/kg body weight from the first to the tenth day of pregnancy (o.p.). The serum concentrations of sodium, potassium and calcium were determined on the 1st, 9th and 14th day o.p. The mother rabbits were killed on the 29th day of o.p., their foetuses were removed and the mucous membrane of the uterus was inspected for resorption sites. The foetuses were examined, the skeletons were stained and studied under the microscope. The results of the treated rabbits were compared with those of the control rabbits. The sodium, potassium and calcium concentrations of the treated rabbits were not lowered significantly. The haematocrite did not change during or after the treatment. The mothers gained weight continuously. The rates of resorption and malformation of the treated group were slightly raised.
D000014:Abnormalities, Drug-Induced / Q000503:physiopathology*; D000818:Animals; D001835:Body Weight / Q000187:drug effects; D002118:Calcium / Q000097:blood; D005260:Female; D005313:Fetal Death / Q000139:chemically induced; D005333:Fetus / Q000473:pathology; D005665:Furosemide / Q000494:pharmacology*; D006400:Hematocrit; D011188:Potassium / Q000097:blood; D011247:Pregnancy; D011817:Rabbits; D012964:Sodium / Q000097:blood; D014599:Uterus / Q000473:pathology
D005665:Furosemide; D012964:Sodium; D011188:Potassium; D002118:Calcium
Tierexperimentelle Untersuchungen zur "dysionischen Genese intrauteriner Missbildungen"