Bronchial deposition of free ions and submicron particles studied in excised lung.
Direct measurements of bronchial deposition in ventilated pig lungs are reported for radon daughter ions and condensation nuclei. Comparisons are made with deposition calculated from the theory of particle diffusion in steady, laminar air-flow. In segmental bronchi, the observed deposition of condensation nuclei was within about 25% of that calculated. Deposition was greater by up to a factor 2 in main stem and lobar bronchi. Deposition in the trachea depended upon the entrance conditions set by vocal cords. For thorium-B ions, deposition in segmental bronchi was a factor 4 less than calculated, apparently due to rapid hygroscopic growth. Clearance rates by dissolution from bronchial epithelium in vivo for lead and bismuth ions are also reported. Approximately 10% of 212Pb ions diffused into blood with a half-time of about 70 min and 30% of 212Bi ions with a much shorter half-time of about 7 min. The implications of these data in the calculation of radiation dose from inhaled radon daughters are discussed.
D000336:Aerosols; D000398:Air Pollution, Radioactive; D000818:Animals; D001729:Bismuth; D001980:Bronchi; D066298:In Vitro Techniques; D007477:Ions; D007854:Lead; D011059:Polonium; D011817:Rabbits; D011868:Radioisotopes; D011886:Radon; D012119:Respiration; D013552:Swine
D000336:Aerosols; D007477:Ions; D011868:Radioisotopes; D007854:Lead; D011059:Polonium; D011886:Radon; D001729:Bismuth