Evidence of calcitonin-induced inhibition of calcitonin secretion in porcine thyroid slices.
In the present study, the possibility of calcitonin-induced self-inhibition in porcine thyroid slices was examined. Replacing the incubation medium at 5-min intervals during incubation and increasing the volume of incubation from 2 to 15 ml were observed to enhance calcium-stimulated calcitonin secretion in vitro.
D000818:Animals; D002116:Calcitonin / Q000378:metabolism* / Q000494:pharmacology; D002118:Calcium / Q000494:pharmacology; D003470:Culture Media; D005246:Feedback; D066298:In Vitro Techniques; D013552:Swine; D013961:Thyroid Gland / Q000187:drug effects / Q000378:metabolism*
D003470:Culture Media; D002116:Calcitonin; D002118:Calcium