Effects of metoprolol and propranolol on furosemide-stimulated renin release in healthy subjects.
The effects of single doses of the beta1-receptor antagonist metoprolol (40 mg orally), propranolol (40 mg orally) and placebo were compared on furosemide-stimulated plasma renin activity (PRA) in seven healthy subjects. In the placebo studies, PRA increased by 0.59+/-0.18 ng x ml-1 x h-1 60 minutes after intravenous administration of 30-60 mg furosemide. After propranolol and metoprolol, the corresponding increases in PRA were significantly less pronounced amounting to 0.16+/-0.06 and 0.24+/-0.08 ng x ml-1 x h-1, respectively. The resting heart rate was reduced to the same extent after the two beta-blockers, which means that the two drugs had been given in equipotent beta1-receptor blocking doses. It is suggested that the release of renin from the kidney may partly be mediated via an adrenergic beta1-receptor.
D000328:Adult; D001794:Blood Pressure / Q000187:drug effects; D005665:Furosemide / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D008297:Male; D010919:Placebos; D011433:Propranolol / Q000494:pharmacology*; D012083:Renin / Q000097:blood*
D010919:Placebos; D005665:Furosemide; D011433:Propranolol; D012083:Renin