Effects of cytosine arabinoside, adenine arabinoside, and 6-azauridine on rabies virus in vitro and in vivo.
The antiviral agents cytosine arabinoside, adenine arabinoside, and 6-azauridine were shown to inhibit the replication of rabies virus in vitro but not the replication of Sindbis virus. These same drugs were not effective in reducing the mortality rate in mice challenged with street rabies virus.
D000818:Animals; D000998:Antiviral Agents / Q000494:pharmacology; D001380:Azauridine / Q000494:pharmacology*; D002460:Cell Line; D003561:Cytarabine / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D004353:Drug Evaluation, Preclinical; D066298:In Vitro Techniques; D051379:Mice; D011684:Purine Nucleosides / Q000494:pharmacology*; D011818:Rabies / Q000188:drug therapy; D011820:Rabies virus / Q000187:drug effects*; D014740:Vidarabine / Q000494:pharmacology*
D000998:Antiviral Agents; D011684:Purine Nucleosides; D003561:Cytarabine; D001380:Azauridine; D014740:Vidarabine