A hexapeptide angiotensin antagonist, Des-(Asp1, Arg2), Ile8)-angiotensin II.
In the smallest biologically active fragment of angiotensin or a 3-8 hexapeptide the C-terminal was substituted by isoleucine residue. It proved to be the smallest potent antagonist of angiotensin II so far reported.
D000804:Angiotensin II / Q000031:analogs & derivatives* / Q000037:antagonists & inhibitors*; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D003106:Colon / Q000187:drug effects; D005260:Female; D009842:Oligopeptides / Q000494:pharmacology*; D010446:Peptide Fragments; D051381:Rats
D009842:Oligopeptides; D010446:Peptide Fragments; D000804:Angiotensin II