[State of the metabolism of thiamine in white rats during the long-term administration of ethanol].
Following introduction of ethyl alcohol in a dose of 4 g/kg for 4 months to rats receiving a solid food ration and 5gamma of thiamine the activity of the erythrocytes transketolase and the thiamine level in the liver did not experience any marked changes, but the transketolase activity in the liver increased. A replacement of one half of carbohydrates in the liquid ration with an isocaloric quantity of ethyl alcohol led over a period of 2 and 4 months to a rise in the activity of the erythocytes transketolase. The thiamine content in the liver mounted too, but then transketolase activity in the liver significantly decreased. The cause accounting for the conflicting liver transketolase changes with different rations and the mechanism of the "thiamine-saving" action of ethyl alcohol are discussed.
D000437:Alcoholism / Q000378:metabolism*; D000818:Animals; D056486:Chemical and Drug Induced Liver Injury / Q000378:metabolism*; D004040:Dietary Carbohydrates; D004912:Erythrocytes / Q000187:drug effects / Q000378:metabolism*; D006801:Humans; D008099:Liver / Q000187:drug effects* / Q000378:metabolism; D008297:Male; D051381:Rats; D013831:Thiamine / Q000378:metabolism*; D014174:Transketolase / Q000378:metabolism
D004040:Dietary Carbohydrates; D014174:Transketolase; D013831:Thiamine
Sostoianie obmena tiamina u belykh krys pri dlitelnom vvedenii étilovogo spirta