Differential effect of cannabinol and cannabidiol on THC-induced responses during abstinence in morphine-dependent rats.
The same dose of cannabinol (CBN) or cannabidiol (CBD) further increased the attenuation of precipitated abstinence signs observed in morphine-dependent rats that also received an acute dose of delta 9-THC. By contrast, rotational behavior (turning), which is observed concomitantly in THC-treated rats during morphine abstinence, was not increased by CBN, but was potentiated by CBD. These data illustrate differences between psychoinactive cannabinoids in their interaction with delta 9-THC that might be relevant to possible clinical use of Cannabis in narcotic detoxification.
D000818:Animals; D002185:Cannabidiol / Q000494:pharmacology*; D002188:Cannabis / Q000494:pharmacology*; D003864:Depression, Chemical; D013759:Dronabinol / Q000494:pharmacology*; D004357:Drug Synergism; D006801:Humans; D008297:Male; D009021:Morphine Dependence / Q000503:physiopathology*; D051381:Rats; D013239:Stereotyped Behavior / Q000187:drug effects; D013375:Substance Withdrawal Syndrome / Q000503:physiopathology*
D002185:Cannabidiol; D013759:Dronabinol