[Normal values for Lactate- and Glutamate dehydrogenate by new optimized methods (author's transl)].
The activities of the enzymes LDH (Lactatdehydrogenase), HBDH (Hydroxybutyratdehydrogenase), and GIDH (Glutamate dehydrogenase), as well as LAP (Leucine aryl peptidase) were measured in the serum of 934 children in order to get normal values of these enzyme activities in dependence on the age. We used again the optimized methods (Boehringer und Merck). The form of the distribution of the single values of these 4 enzymes can be described by a lognormal distribution. This applies not to newborns and young sucklings. All measured enzyme activities were depended on the age of the children; newborn and sucklings had significantly higher enzyme activities than infants. After the second year of life the enzyme activities for LDH, HBDH, GlDH and LAP remained constantly. The physiological variations are very high in the newborns. The diagnostic selectivity of the enzyme GIDH is very good, this of LDH and HBDH turned out unspecifically. No difference could be supplied for the sex of the children.
D000293:Adolescent; D000367:Age Factors; D000410:Alanine Transaminase / Q000097:blood; D001219:Aspartate Aminotransferases / Q000097:blood; D002648:Child; D002675:Child, Preschool; D005969:Glutamate Dehydrogenase / Q000097:blood*; D006801:Humans; D006884:Hydroxybutyrate Dehydrogenase / Q000097:blood; D007223:Infant; D007231:Infant, Newborn; D007770:L-Lactate Dehydrogenase / Q000097:blood*; D007931:Leucyl Aminopeptidase / Q000097:blood*
D007770:L-Lactate Dehydrogenase; D006884:Hydroxybutyrate Dehydrogenase; D005969:Glutamate Dehydrogenase; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase; D007931:Leucyl Aminopeptidase
Normalwerte für Lactat- und Glutamatdehydrogenase, sowie Leucinarylamidase, erstellt mit optimierten Standardansätzen