[Antiheparin properties of synthetic polycations].
The toxicity of differently structured polymeric compounds for mice (intravenously) and their antiheparin properties in in vitro and in vivo tests were studied. The antiheparin activity display polymers containing amino groups or onium atoms of nitrogen, sulphur and phosphorus in various structures. The antagonism to heparin is due to the polymers being endowed with polycationic properties.
D000818:Animals; D001769:Blood / Q000187:drug effects; D001777:Blood Coagulation / Q000187:drug effects; D001780:Blood Coagulation Tests; D005260:Female; D005340:Fibrinogen / Q000032:analysis; D006494:Heparin Antagonists / Q000494:pharmacology* / Q000633:toxicity; D007928:Lethal Dose 50; D008297:Male; D051379:Mice; D008970:Molecular Weight; D011108:Polymers / Q000494:pharmacology* / Q000633:toxicity; D011817:Rabbits; D051381:Rats; D013917:Thrombin / Q000032:analysis; D013997:Time Factors
D006494:Heparin Antagonists; D011108:Polymers; D005340:Fibrinogen; D013917:Thrombin
Antigeparinovye svoĭstva sinteticheskikh polikationov