[Action of fomocaine on heart and circulation (author's transl)].
Fomocaine shows antiarrhythmic properties. It prolongs the periods of the ECG (anaesthetized cats) and the functional refractory period (left atria of guinea-pigs, electrically driven). Effects on these parameters are qualitatively the same as with quinidine. Quantitatively fomocaine prolongs the functional refractory period in the same, the PQ-interval to a greater extent than does quinidine. In contrast quinidine has a greater effect on QRS- and QT-interval. Up to higher doses fomocaine's efficacy on contractility (dp/dtmax) and blood pressure is opposite to quinidine because they are increased by fomocaine and decreased by quinidine. The lack of toxic ECG-signs prior to lethal dosis makes fomocaine dangerous in overdosage.
D000818:Animals; D000889:Anti-Arrhythmia Agents; D001794:Blood Pressure / Q000187:drug effects; D002415:Cats; D004305:Dose-Response Relationship, Drug; D004353:Drug Evaluation, Preclinical; D004562:Electrocardiography; D006168:Guinea Pigs; D006321:Heart / Q000187:drug effects*; D006325:Heart Atria / Q000187:drug effects; D006352:Heart Ventricles / Q000187:drug effects; D007275:Injections, Intravenous; D009025:Morpholines / Q000494:pharmacology*; D009200:Myocardial Contraction / Q000187:drug effects; D010647:Phenyl Ethers / Q000494:pharmacology; D011802:Quinidine / Q000494:pharmacology; D013997:Time Factors
D000889:Anti-Arrhythmia Agents; D009025:Morpholines; D010647:Phenyl Ethers; D011802:Quinidine
Herz-Kreislaufwirkungen des Fomocains