Effect of some irritants on human epidermal mitosis.
Studies on how irritant materials might induce epidermal hyperplasia were initiated by investigating their influence on epidermal mitosis. 5% hydrochloric acid, neat dimethyl acetamide and 1% benzalkonium chloride had no effect. 5% benzalkonium chloride, however, produced a 10-fold increase in mitotic activity, while a dose response curve was seen with sodium lauryl sulphate (SLS) peaking at 1%. 1% SLS produced a remarkably uniform response for this type of assay and it is suggested that it might provide a useful model for situations of increased epidermal cell turnover such as psoriasis. It is also noted that there was apparently no direct relationship between gross inflammation and the mitotic response.
D000081:Acetamides / Q000494:pharmacology; D000328:Adult; D000485:Allergens / Q000494:pharmacology*; D001548:Benzalkonium Compounds / Q000494:pharmacology; D006801:Humans; D006851:Hydrochloric Acid; D006965:Hyperplasia / Q000139:chemically induced; D007509:Irritants; D008297:Male; D008938:Mitosis / Q000187:drug effects*; D010328:Patch Tests; D012867:Skin / Q000187:drug effects* / Q000473:pathology; D012967:Sodium Dodecyl Sulfate / Q000494:pharmacology; D013997:Time Factors
D000081:Acetamides; D000485:Allergens; D001548:Benzalkonium Compounds; D007509:Irritants; D012967:Sodium Dodecyl Sulfate; D006851:Hydrochloric Acid