title: [The mutagenicity of desmethyltrichlorphone in dominant lethal test on mice (author's transl)].
abstract: After i.p. administration to AB mice of 405 mg/kg desmethyltrichlorphone (sodium salt) in a single dose and 54 mg/kg daily for 3 weeks, the mutagenic effect in the dominant lethal test was at least the same as that of trichlorphone. these findings indicate that the genotoxic effect of trichlorphone is not likely to be due to its alkylating properties.
mesh_terms: D000818:Animals; D010064:Embryo Implantation / Q000187:drug effects; D005260:Female; D005313:Fetal Death / Q000139:chemically induced; D005333:Fetus / Q000187:drug effects; D005799:Genes, Dominant; D005804:Genes, Lethal; D008297:Male; D051379:Mice; D009153:Mutagens; D009154:Mutation; D011247:Pregnancy; D013997:Time Factors; D014236:Trichlorfon / Q000031:analogs & derivatives* / Q000633:toxicity
chemical_list: D009153:Mutagens; D014236:Trichlorfon
vernacular_title: Zur Mutagenität von Desmethyl-Trichlorphon im Dominanten-Letal-Test an der Hausmaus