[On the toxicity of CT-1341 evoked by long-term administration. III. Subacute toxicity of alphadolone acetate and solvent contained in CT-1341 (author's transl)].
Subacute toxicity of solvent adjuvant, alphadolone acetate and solvent, 20 per cent Cremophor solution contained in CT-1341 was studied by using rats of both sexes. Alphadolone acetate and Cremophor solution were intraperitoneally injected every day for a period of one month. Total rats tolerated to daily administration of 60 mg/kg of alphadolone acetate or of 20 ml/kg of 20 per cent Cremophor solution, without showing significant changes in body weight curves and food intake. No change was observed in blood cells and in biochemical data of blood and urine as compared with control. Rats subjected to daily administration of 60 mg/kg of alphadolone acetate presented slight patho-histological changes such as swelling of cells of the liver and kidneys, and also cell infiltration of pericapillary tissues of the lung.
D000530:Alfaxalone Alfadolone Mixture / Q000633:toxicity*; D000818:Animals; D001835:Body Weight / Q000187:drug effects; D002368:Castor Oil / Q000633:toxicity; D005260:Female; D007668:Kidney / Q000187:drug effects / Q000473:pathology; D008099:Liver / Q000187:drug effects / Q000473:pathology; D008168:Lung / Q000187:drug effects / Q000473:pathology; D008297:Male; D009929:Organ Size; D011092:Polyethylene Glycols / Q000633:toxicity; D011277:Pregnanediones / Q000633:toxicity*; D051381:Rats; D012997:Solvents / Q000633:toxicity; D013997:Time Factors
D011277:Pregnanediones; D012997:Solvents; D011092:Polyethylene Glycols; D002368:Castor Oil; D000530:Alfaxalone Alfadolone Mixture