Lack of immune tolerance to hepatitis B antigen in offsprings of guinea pigs injected with HB ag during pregnancy.
Immune tolerance to hepatitis B antigen has been examined in the guinea pig. The offsprings of guinea pigs injected with purified HB Ag during pregnancy were found capable of producing HB antibodies. Purified HB Ag is suitable for producing immune serum for the systemic screening of blood donors for HB Ag.
D000818:Animals; D000914:Antibodies, Viral / Q000096:biosynthesis; D005260:Female; D006168:Guinea Pigs; D006511:Hepatitis B Antigens / Q000008:administration & dosage*; D006801:Humans; D007108:Immune Tolerance; D007114:Immunization; D008297:Male; D008431:Maternal-Fetal Exchange; D008954:Models, Biological; D011247:Pregnancy
D000914:Antibodies, Viral; D006511:Hepatitis B Antigens