Murine and rat mammary tumors as models for the immunological study of human breast cancer.
The human breast cancer process and some aspects of experimental mammary cancer are compared in the light of Huxley's hypothesis that each neoplastic cell line may be viewed as a new obligate parasitic species derived from metazoan cells. Sufficient correlations are found to justify the hope that the viral-induced mouse mammary oncogenic process and the carcinogen-induced rat mammary system may serve as reasonable models of the human disease for immunological studies.
D000367:Age Factors; D000818:Animals; D002471:Cell Transformation, Neoplastic; D004195:Disease Models, Animal; D008325:Mammary Neoplasms, Experimental / Q000139:chemically induced / Q000209:etiology / Q000276:immunology*; D051379:Mice; D008815:Mice, Inbred Strains; D011230:Precancerous Conditions / Q000473:pathology; D011374:Progesterone / Q000502:physiology; D011388:Prolactin / Q000502:physiology; D051381:Rats
D011374:Progesterone; D011388:Prolactin