Specificity of neonatal, androgen-induced imprinting of hepatic steroid metabolism in rats.
The specificity of the neonatal, andreogen-induced, irreversible programming of hepatic steroid metabolism in the rat was investigated. 5-alpha-Dihydrotestosterone propionate and estradiol benzoate were as efficient as testosterone propionate in inducing a male type of liver metabolism in the adult animal, whereas epitestosterone propionate, etiocholanolone propionate, and o,p'-DDT were practically inactive in this respect. These findings indicate that different mechanisms are involved in neonatal imprinting of hepatic steroid metabolism and in the well-known neonatal androgenic and estrogenic induction of persistent estrus and acyclic gonadotropin secreqion.
D000728:Androgens / Q000494:pharmacology*; D015113:Androstane-3,17-diol / Q000378:metabolism*; D000731:Androstanes / Q000378:metabolism*; D000735:Androstenedione / Q000378:metabolism*; D000818:Animals; D000831:Animals, Newborn / Q000378:metabolism*; D003634:DDT / Q000494:pharmacology; D013196:Dihydrotestosterone / Q000494:pharmacology; D004845:Epitestosterone / Q000494:pharmacology; D004958:Estradiol / Q000494:pharmacology*; D005043:Etiocholanolone / Q000494:pharmacology; D008099:Liver / Q000187:drug effects / Q000201:enzymology / Q000378:metabolism*; D008297:Male; D051381:Rats; D012733:Sex Differentiation / Q000187:drug effects; D013739:Testosterone / Q000494:pharmacology
D000728:Androgens; D000731:Androstanes; D013196:Dihydrotestosterone; D015113:Androstane-3,17-diol; D013739:Testosterone; D000735:Androstenedione; D004845:Epitestosterone; D004958:Estradiol; D005043:Etiocholanolone; D003634:DDT