title: An improved technique for nasal inhalation challenge tests.
abstract: An improved technique for nasal inhalation challenge tests is described. It includes an improved delivery system utilizing a Maxi-Myst air compressor delivering a flow of room air controlled by an in-line, electroncially timed solenoid which precisely controls the duration of compressor activity. A No. 251 DeVilbiss atomizer will deliver 0.1 + 0.01 gm/spray when the flow rate is 11.5 L/min, the duration of atomizer activity is approximately 0.1 sec, and the amount of liquid in the atomizer insert is kept between 0.75 and 2.0 ml. Nasal aerosol challenge of 0.1 ml of isotonic phosphate-buffered saline per nostril produced less variability in nasal airway resistance (NAR) response than 0.2 ml, and the smaller volume proved satisfactory for 6 consecutive saline challenges at 15-min intervals. A new face mask, which did not impinge on the bridge of the nose or paranasal structures, yielded lower baseline values of nasal airway resistance and much less variability in these measurements. Techniques employed in objectively quantitating nasal responses to various exogenous substances are briefly but critically reviewed.
mesh_terms: D000281:Administration, Intranasal; D000336:Aerosols; D000403:Airway Resistance / Q000187:drug effects*; D006801:Humans; D008397:Masks; D012129:Respiratory Function Tests / Q000295:instrumentation; D012965:Sodium Chloride / Q000494:pharmacology; D013696:Temperature
chemical_list: D000336:Aerosols; D012965:Sodium Chloride