The effect of hypertonic saline on human corneal hydration.
Hydrophilic gel contact lenses, presoaked in various strength saline solutions, were held in intimate contact with the in vivo human cornea. A change in corneal water content was observed taking place against the induced osmotic gradient. Direct stimulation of some aspect of the mechanisms controlling corneal hydration is postulated, in a manner which may be similar to that previously reported for the in vitro rabbit cornea.
D002712:Chlorides / Q000032:analysis; D003263:Contact Lenses, Hydrophilic; D003315:Cornea / Q000033:anatomy & histology / Q000187:drug effects*; D003316:Corneal Diseases / Q000628:therapy; D004305:Dose-Response Relationship, Drug; D006801:Humans; D012462:Saline Solution, Hypertonic / Q000494:pharmacology*; D012965:Sodium Chloride / Q000494:pharmacology*; D013997:Time Factors
D002712:Chlorides; D012462:Saline Solution, Hypertonic; D012965:Sodium Chloride