The control of brain tryptophan concentration.
Addition of linoleic acid to rat plasma caused increased uptake of radioactive tryptophan by incubated brain slices. Addition of competing amino acids within the physiological range of their concentrations had negligible effect. Rat midbrain tryptophan concentration in vivo correlated significantly with plasma free tryptophan. These results are consistent with previous work indicating the importance of plasma free tryptophan as a determinant of brain tryptophan concentration.
D000818:Animals; D001921:Brain / Q000187:drug effects / Q000378:metabolism*; D008041:Linoleic Acids / Q000494:pharmacology; D051381:Rats; D014364:Tryptophan / Q000378:metabolism*
D008041:Linoleic Acids; D014364:Tryptophan