Cellular immune response to acetylcholine receptor-rich fraction, in patients with myasthenia gravis.
Lymphocytes from patients with myasthenia gravis were stimulated when cultured in vitro with an electric eel extract enriched in acetylcholine receptor. No stimulation was observed with other antigens from nerve or muscle origin. Lymphocytes from non-myasthenic patients showed no response to any of these antigens. These findings suggest that an in vivo sensitization of lymphocytes to self acetylcholine receptor may occur in myasthenia gravis. The presence of sensitized lymphocytes, probably resulting from an autoimmune mechanism, might be an important factor in the pathogenesis of the neuromuscular block in this disease.
D000109:Acetylcholine / Q000276:immunology*; D000293:Adolescent; D000328:Adult; D000368:Aged; D000818:Animals; D002800:Cholinesterase Inhibitors / Q000627:therapeutic use; D004593:Electrophorus / Q000276:immunology; D005260:Female; D006801:Humans; D007111:Immunity, Cellular; D008213:Lymphocyte Activation; D008297:Male; D008875:Middle Aged; D009157:Myasthenia Gravis / Q000188:drug therapy / Q000276:immunology*; D011241:Prednisone / Q000627:therapeutic use; D011950:Receptors, Cholinergic
D002800:Cholinesterase Inhibitors; D011950:Receptors, Cholinergic; D000109:Acetylcholine; D011241:Prednisone