title: Treatment of bronchospasm during anesthesia.
abstract: During anesthesia, wheezing and difficult breathing are dangerous, requiring prompt therapy. The pressurized isoproterenol cartridge described in this report may be interposed conveniently in the anesthesia breathing system, is inexpensive, and provides accurate dosage. This device proved effective in treating bronchospasm and decreasing wheezing and secretions in 11 out of 12 cases. The mean (+/- SEM) peak airway pressure was 43 (+/- 2) torr before and 31 (+/- 2) torr after treatment; mean Paco2 was lowered from 60 (+/- 6) to 47 (+/- 4) torr; mean pH increased from 7.24 (+/- 0.03) to 7.33 (+/- 0.03), and mean percent increase in Pao2 was 32 (+/- 13.4). No cardiac arrhythmias, tachycardia, or rise in blood pressure were observed.
mesh_terms: D000328:Adult; D000368:Aged; D000768:Anesthesia, General / Q000009:adverse effects*; D001986:Bronchial Spasm / Q000188:drug therapy* / Q000209:etiology; D005260:Female; D006801:Humans; D007545:Isoproterenol / Q000008:administration & dosage / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged
chemical_list: D007545:Isoproterenol