Transport of oxygen and carbon dioxide by hemoglobin-saline solution in the red cell-free primate.
This study was undertaken to investigate the respiratory properties of hemoglobin-saline solution. Eighteen baboons were exchange transfused with either 6 per cent dextran or 6 per cent hemoglobin-saline solution. All of the hemoglobin-saline solution treated baboons survived three hours at a zero hematocrit reading. All the dextran treated animals died when the hematocrit level fell below 6 per cent. Oxygen consumption and carbon dioxide production remained unchanged from base line during the zero hematocrit interval. It is concluded that the respiratory capability of hemoglobin-saline solution is sufficient to maintain life in the absence of erythrocytes.
D000818:Animals; D001692:Biological Transport; D001794:Blood Pressure; D002245:Carbon Dioxide / Q000378:metabolism*; D002302:Cardiac Output; D003911:Dextrans / Q000378:metabolism; D004912:Erythrocytes / Q000378:metabolism; D006400:Hematocrit; D006454:Hemoglobins / Q000378:metabolism*; D010101:Oxygen Consumption; D010215:Papio / Q000378:metabolism*; D010313:Partial Pressure; D010952:Plasma Substitutes / Q000378:metabolism*; D012965:Sodium Chloride / Q000378:metabolism
D003911:Dextrans; D006454:Hemoglobins; D010952:Plasma Substitutes; D002245:Carbon Dioxide; D012965:Sodium Chloride