Correlation between biochemical and contractile changes after myocardial ischemia and revascularization.
Regional contractility measured as myocardial fiber shortening ceased 15-30 sec after coronary occlusion; myocardial ATP content was unaltered at this time. Contractility returned promptly if occlusion was released within 45 min. With occlusion of 1-3 hr, delayed recovery of contractility was observed 2 weeks after reperfusion; the extent of recovery diminshed with increasing period of occlusion. Concomitantly, there was parallel recovery of synthesis of ATP and creatine phosphate (CP) in reperfused myocardium.
D000255:Adenosine Triphosphate / Q000378:metabolism; D000818:Animals; D003327:Coronary Disease / Q000378:metabolism / Q000503:physiopathology*; D004285:Dogs; D006321:Heart / Q000503:physiopathology*; D009200:Myocardial Contraction; D009206:Myocardium / Q000378:metabolism; D010477:Perfusion; D010725:Phosphocreatine / Q000378:metabolism
D010725:Phosphocreatine; D000255:Adenosine Triphosphate