title: Comparative studies on the effect of oxygen high pressure (OHP) on different species; with special reference to the organ preservation.
abstract: Different species of animals (warm-blooded, poikilotherms and cold-blooded) were exposed to oxygen high pressure (OHP) (1-4 ata) for 2-8 h. OHP revealed (a) a different vulnerability in various species; (b) an inverse correlation between basal oxygen consumption and their vulnerability; (c) the critical point of the toxic effect of OHP in normothermia was an exposition time of 2 h with 2 ata OHP; (d) morphological changes of lung, CNS and vessels -- intense folding of alveolar septa with cell hyperplasia and hypertrophy; (e) electron-microscopical demonstration of damaged endothelial cells with total or partial occlusion of the capillaries.
mesh_terms: D000818:Animals; D001808:Blood Vessels / Q000187:drug effects; D010856:Columbidae; D006224:Cricetinae; D005399:Fishes; D005880:Gills / Q000187:drug effects; D006168:Guinea Pigs; D006931:Hyperbaric Oxygenation / Q000009:adverse effects*; D008168:Lung / Q000187:drug effects; D009926:Organ Preservation; D010100:Oxygen / Q000633:toxicity; D010101:Oxygen Consumption; D051381:Rats; D013045:Species Specificity; D013997:Time Factors
chemical_list: D010100:Oxygen