Antitussive activity of some naturally occurring cannabinoids in anesthetized cats.
Experimental cough was elicited in pentobarbital-anesthetized cats by either electrical stimulation of the superior laryngeal nerve or by mechanical stimulation of the tracheal mucosa. Intravenous administration of delta9-tetrahydrocannabinol (THC) effectively reduced the amplitude of the cough response in both these models of experimentally induced cough with ED50 values (AtD50) of 1.84 and 0.78 mg/kg, respectively. This cough suppressant activity of THC was more similar to codeine-PO4 than dextromethorphan-HBr. On the other hand, both cannabinol (CBN) and cannabidiol (CBD) were devoid of antitussive activity at doses as high as 10.0 mg/kg.
D000818:Animals; D000996:Antitussive Agents / Q000008:administration & dosage / Q000627:therapeutic use; D002185:Cannabidiol / Q000494:pharmacology; D002188:Cannabis / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D002415:Cats; D003061:Codeine / Q000494:pharmacology; D003371:Cough / Q000188:drug therapy; D003915:Dextromethorphan / Q000494:pharmacology; D013759:Dronabinol / Q000494:pharmacology; D004558:Electric Stimulation; D005260:Female; D007275:Injections, Intravenous; D007823:Laryngeal Nerves / Q000502:physiology; D008297:Male; D010812:Physical Stimulation; D008517:Phytotherapy; D012119:Respiration / Q000187:drug effects; D014132:Trachea / Q000502:physiology
D000996:Antitussive Agents; D002185:Cannabidiol; D003915:Dextromethorphan; D013759:Dronabinol; D003061:Codeine