[Studies on metabolism and pharmacokinetics of alpha-acetyldigitoxin in man (author's transl)].
3H-alpha-Acetyl-digitoxin was administered to 5 patients i.v. and 3 patients p.o. The half-life of label in the plasma was 8.5 +/- 1 (i.v.) and 8.8 +/- 1 (p.o.) days. 20.9 +/- 3.6% (i.v.) and 21.3 +/- 2.9% (p.o.) of the radioactive dose were excreted into the urine in 6 days. Two patients excreted within 18 days 14.3 and 16.1% of the given dose with the stool. After oral administration 22.3% of the orally administered 3H-activity were eliminated into the feces by one patient. 63% (i.v.) and 53% (p.o.) of the chlorofrom-extracted 3H-activity in the urine could be attributed to digitoxin by means of thin-layer chromatography. The volatile content of plasma radioactivity was 4.07 +/- 0.1% (i.v.) and 6.78 +/- 0.2% (p.o.). The protein binding of a 4%. Albumin solution was 83 +/- 0.54%, for plasma 80.8 +/- 2%.
D000112:Acetyldigitoxins / Q000008:administration & dosage / Q000378:metabolism; D000284:Administration, Oral; D000368:Aged; D002318:Cardiovascular Diseases / Q000378:metabolism; D002855:Chromatography, Thin Layer; D004074:Digitoxin / Q000031:analogs & derivatives*; D006207:Half-Life; D006801:Humans; D006868:Hydrolysis; D007275:Injections, Intravenous; D007700:Kinetics; D008875:Middle Aged; D011485:Protein Binding; D012709:Serum Albumin / Q000378:metabolism
D000112:Acetyldigitoxins; D012709:Serum Albumin; D004074:Digitoxin
Untersuchungen zum Stoffwechsel und zur Pharmakokinetik von alpha-Acetyldigitoxin beim Menschen