[The effect of synthetic derivatives of testosterone on the activity of acid proteinases, DNA-ase and RNA-ase in the liver and serum of female rats].
A study was made of the effect of a 30-day administration of various doses of testosterone-propionate and methyltestosterone to intact female rats given a ration rich in protein on the activity of acid DNA-ase, RNA-ase and proteinases in the liver and the blood serum. The ration itself, rich in proteins, increased the activity of acid RNA in the liver of rats and gave a significant seasonal variations in the activity of RNA-ase and proteinases. Administration of the same doses (1 mg daily) of testosterone-propionate or methyltestosterone produced a different effect on the nuclease metabolism. In the first case there was observed a reduction of the RNA-ase activity, and in the second--of the DNA-ase. Possibly this partially explained a different extent of anabolic properties of these two androgens. An increase in the dose of methyltestosterone to 5 mg, on the contrary, produced activation of RNA-ase in the liver and the blood serum, which could promote the manifestation of catabolic properties.
D000818:Animals; D003851:Deoxyribonucleases / Q000097:blood / Q000378:metabolism*; D005260:Female; D008099:Liver / Q000201:enzymology*; D008777:Methyltestosterone / Q000494:pharmacology*; D010447:Peptide Hydrolases / Q000097:blood / Q000378:metabolism*; D051381:Rats; D012260:Ribonucleases / Q000097:blood / Q000378:metabolism*; D013268:Stimulation, Chemical; D013739:Testosterone / Q000494:pharmacology
D013739:Testosterone; D003851:Deoxyribonucleases; D012260:Ribonucleases; D010447:Peptide Hydrolases; D008777:Methyltestosterone
Vliianie sinteticheskikh proizvodnykh testosterona na aktivnost' kislykh proteinaz, DNK-azy i RNK-azy pecheni i syvorotki krovi krys-samok