[Study of the dynamic distribution of azafen in the organs and tissues by using direct fluorimetry].
A quantitative method of direct fluometry of the samples without any preliminary extraction of the preparation, devised by the authors helped demonstrate that after its intravenous administration the cyclic antidepressant azaphen rapidly penetrates via the blood-cerebral, blood-ophthalmic, placental and other blood-histological barrier and is then quickly eliminated from the organism.
D000818:Animals; D000929:Antidepressive Agents, Tricyclic / Q000378:metabolism*; D001769:Blood / Q000378:metabolism; D001812:Blood-Brain Barrier / Q000187:drug effects; D001921:Brain / Q000378:metabolism; D004305:Dose-Response Relationship, Drug; D005260:Female; D005470:Fluorometry / Q000379:methods*; D008099:Liver / Q000378:metabolism; D008297:Male; D008431:Maternal-Fetal Exchange / Q000187:drug effects; D008856:Microscopy, Fluorescence / Q000379:methods; D010078:Oxazines / Q000378:metabolism*; D011247:Pregnancy; D051381:Rats; D013050:Spectrometry, Fluorescence / Q000295:instrumentation; D013997:Time Factors
D000929:Antidepressive Agents, Tricyclic; D010078:Oxazines
Izuchenie raspredeleniia azafena po organam i tkaniam v dinamike pri pomoshchi neposredstvennoĭ fliuorimetrii