Effect of uninephrectomy on tissue kallicrein concentration of the remaining kidney.
Compensatory renal hypertrophy has been induced in rats by uninephrectomy. Tissue kallicrein concentration of the remaining kidney was evaluated 5, 10, 15 and 20 days after operation. The previously removed kidneys were used as controls. In the hypertrophic kidney the kallicrein increases progressively up to 20 days after uninephrectomy. Since kallicrein generates kinins, potent vasodilators, it is suggested that the increase in renal blood flow observed after uninephrectomy might be promoted by an overproduction of kinins.
D000818:Animals; D006984:Hypertrophy; D007610:Kallikreins / Q000096:biosynthesis*; D007668:Kidney / Q000378:metabolism / Q000502:physiology; D008297:Male; D009392:Nephrectomy; D014176:Protein Biosynthesis; D051381:Rats
D007610:Kallikreins