[The effect of adrenoblockaders on the rate of H3-catecholamine synthesis and uptake in the rat seminal duct].
In the rat vas deferens alpha-adrenoblocking agent phentolamine (1-10(-6)M) and beta-adrenoblocking agent propranolol (1-10(-6)M) activated uptake of exogenous noradrenaline--H-3 by 37 and 47% respectively and synthesis of noradrenaline--H3 from thyrosin-H3 by 72 and 48%. The rate of noradrenaline-H3 synthesis from DOPA-H3 or dopamine-H3 remains unaltered. Regulating effect of the adrenoblocking agents is carried out by means of uptake of tyrosine-H3 and noradrenaline-H3 into adrenergic neuron, i.e. at the main stages sustaining a necessary level of mediator. The rate of noradrenaline biosynthesis is supposed to be independently regulated by means of both types of adrenoreceptors in an adrenergic neuron.
D000818:Animals; D004295:Dihydroxyphenylalanine / Q000378:metabolism; D004298:Dopamine / Q000378:metabolism; D008297:Male; D009638:Norepinephrine / Q000096:biosynthesis / Q000378:metabolism*; D010646:Phentolamine / Q000494:pharmacology*; D011433:Propranolol / Q000494:pharmacology*; D051381:Rats; D011941:Receptors, Adrenergic; D014443:Tyrosine / Q000378:metabolism; D014649:Vas Deferens / Q000378:metabolism*
D011941:Receptors, Adrenergic; D014443:Tyrosine; D004295:Dihydroxyphenylalanine; D011433:Propranolol; D004298:Dopamine; D009638:Norepinephrine; D010646:Phentolamine
Vliianie adrenoblokatorov na skorost' sinteza i zakhvata katekholaminov-H3 v semiavynosiashchem protoke