Effects of anesthetics and other drugs on pulmonary vasoconstriction in hypoxic areas of the lung.
Experiments in isolated perfused cat lungs and in intact dogs indicate that clinically-used concentrations of inhalational anesthetics can produce a reversible depression of the pulmonary vasoconstrictor mechanism which is believed to divert blood flow away from underventilated (i.e. hypoxic) areas of lung. It is possible that this mechanism may increase arterial hypoxaemia during anesthesia.
D000768:Anesthesia, General; D000777:Anesthetics / Q000009:adverse effects*; D000818:Animals; D002415:Cats; D004285:Dogs; D000860:Hypoxia / Q000139:chemically induced* / Q000503:physiopathology; D008168:Lung / Q000187:drug effects* / Q000503:physiopathology; D011652:Pulmonary Circulation / Q000187:drug effects
D000777:Anesthetics