Isolation and properties of a 7 S rat immunoglobulin different from IgG.
A 7 S rat immunoglobulin, of rapid electrophoretic mobility, was characterized and isolated from normal or hyperimmune rat serum and was designated "IgR". This immunoglobulin belongs to a class different from IgG and was originally described as IgA. IgR has a molecular weight of 160 000, is present in the serum and milk as a monomer and is readily absorbed by the intestine of suckling rats. In hyperimmunized animals, about 20% of the antibodies were of the IgR class. IgR is devoid of anaphylactic capacity and no homologies could be established between it and immunoglobulins of other animal species.
D000818:Animals; D005260:Female; D007074:Immunoglobulin G / Q000302:isolation & purification*; D007136:Immunoglobulins / Q000145:classification*; D008431:Maternal-Fetal Exchange; D008892:Milk / Q000276:immunology; D008970:Molecular Weight; D011247:Pregnancy; D051381:Rats / Q000276:immunology*; D013045:Species Specificity
D007074:Immunoglobulin G; D007136:Immunoglobulins