[The effect of hydrocortisone on DNA synthesis by sebaceous gland epithelial cells].
The autoradiography method demonstrated a single injection of hydrocortisone (10 mg per 100 g of body weight) to result in suppression of the cell transition from the G1 phase of the mitotic cycle to the S phase and in prolongation of the S phase of the epithelium of the acinar portion (sebocytes) and stratified epithelium of the excretory ducts of the sebaceous gland of rats. Later, after a decrease of the proliferative processes by hydrocortisone there occurred their increase which was higher than control. Hydrocortisone induced a more pronounced effect on the proliferative activity of the stratified epithelium of the excretory ducts than on the sebocytes of the acini.
D000818:Animals; D004247:DNA / Q000096:biosynthesis*; D006854:Hydrocortisone / Q000494:pharmacology*; D008297:Male; D008938:Mitosis / Q000187:drug effects; D051381:Rats; D012627:Sebaceous Glands / Q000166:cytology / Q000187:drug effects* / Q000378:metabolism
D004247:DNA; D006854:Hydrocortisone
Deĭstvie gidokortizona na sintez DNK kletkami épiteliia sallnykh zhelez