Effect of bone marrow suppression on granulocyte opsonin levels.
Levels of serum opsonin for neutrophilic granulocytes were measured in dogs made neutropenic by cyclophosphamide administration. Heat-labile opsonin became elevated within 24 hr following cyclophosphamide (P less than 0.005) and remained elevated over the 4-5 day period of observation (P less than 0.005). In contrast, heat stable opsonin was not significantly effected. Bone marrow suppression by X-ray and busulfan also caused serum opsonin levels to increase. Changes in the levels of IgG, C3, and total hemolytic complement during the course of bone marrow suppression did not correlate with the granulocyte opsonin levels. These findings suggest that serum granulocyte opsonin levels respond to bone marrow suppression and may provide an improved environment for the function of transfused granulocytes.
D000380:Agranulocytosis / Q000378:metabolism*; D000818:Animals; D002066:Busulfan; D003176:Complement C3 / Q000032:analysis; D003165:Complement System Proteins / Q000032:analysis; D003520:Cyclophosphamide; D004285:Dogs; D006098:Granulocytes / Q000378:metabolism*; D006358:Hot Temperature; D007074:Immunoglobulin G / Q000032:analysis; D007962:Leukocytes / Q000378:metabolism*; D009503:Neutropenia / Q000139:chemically induced / Q000378:metabolism*; D009895:Opsonin Proteins / Q000096:biosynthesis*; D010587:Phagocytosis; D011830:Radiation Effects; D014965:X-Rays
D003176:Complement C3; D007074:Immunoglobulin G; D009895:Opsonin Proteins; D003520:Cyclophosphamide; D003165:Complement System Proteins; D002066:Busulfan