title: Venous air embolism prophylaxis with a surface-active agent.
abstract: The protective effect of a nonionic surface-active polyol agent (Pluronic F-68) against bolus injection and constant-rate IV infusion of air was studied in 21 dogs anesthetized with pentobarbital. Aortic, pulmonary artery and right ventricular pressures, cardiac output, end-tidal CO2 concentration, wasted ventilation, and blood surface tensions were measured before and after the IV administration of this surfactant. The magnitudes of change in the cardiorespiratory responses measured after venous air embolism were significant (p less than 0.05) reduced in the treated animals. This agent may be advantageous for surgical patients when an increased risk of venous air embolism exists.
mesh_terms: D000818:Animals; D004285:Dogs; D004618:Embolism, Air / Q000517:prevention & control*; D008297:Male; D011655:Pulmonary Embolism / Q000517:prevention & control*; D013501:Surface-Active Agents / Q000627:therapeutic use*; D014680:Veins
chemical_list: D013501:Surface-Active Agents