[Ethacrynic acid does not disrupt homeostatic reactions of the kidneys to hemodynamic shifts].
Arterial pressure and diuresis were determined in anesthetized dogs against the background of single (15 mg/kg) and continuous (5 mg/kg/rhr) intravenous administration of uregit (etacrylic acid). Acute hemodynamic shifts produced by compression of common carotid arteries, vena cava anterior, intravenous administration of ephedrine (1 mg/kg) or of sodium nitrite (3 mg/kg) were attended by an increased renal excretion of sodium, potasium and water in hypertension and their passage - in hypertension. Mechaninisms  governing the express regulation of the water and electrolytes homeostasis and their relation to the active transpor of sodium are considered. Arguments in favour of a conjecture as to the localization of the mechanism responsible for the express regulation of the electrolytes homeostasis in acute hemodynamic shifts are advanced.
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D002339:Carotid Arteries / Q000502:physiology; D004231:Diuresis / Q000187:drug effects; D004285:Dogs; D004573:Electrolytes / Q000652:urine; D004809:Ephedrine / Q000494:pharmacology; D004976:Ethacrynic Acid / Q000494:pharmacology*; D006439:Hemodynamics / Q000187:drug effects*; D006706:Homeostasis / Q000187:drug effects*; D007668:Kidney / Q000187:drug effects*; D008026:Ligation; D009573:Nitrites / Q000494:pharmacology; D014556:Urine / Q000032:analysis; D014682:Vena Cava, Inferior / Q000502:physiology; D014882:Water-Electrolyte Balance / Q000187:drug effects
D004573:Electrolytes; D009573:Nitrites; D004809:Ephedrine; D004976:Ethacrynic Acid
Etakrinovaia kislota ne narushaet gomeostaticheskikh reaktsiĭ pochek na gemodinamicheskie sdvigi