title: [Studies on the modification of methionine imbalance in rats through the supplementation of threonine, serine, glycine or glutamic acid].
abstract: Experimental rats were fed a basal diet containing about 10% of crude protein from casein which was supplemented with 5 g DL methionine per 100 g of food. Simultaneously, either threonine, serine, glycine or glutamic acid were added in amounts of 5 gms. After a 7-day feeding period the experimental animals were injected 35S-methionine. The animals were killed after an incorporation period of 24 hrs and the 35S activity measured in different organs and in the excreta. The pattern of body weight gains, and the values for 35S activity showed that glycine had reduced the toxic action of methionine. Threonine was shown to have a similar effect while, under the prevailing conditions, serine augmented the symptoms of toxocity. Definitely higher levels of 35S activity found in the residual carcasses after methionine or serine supplementation seem to suggest an increase in cystein formation in intermediary metabolism. This, in turn, delays the elimination of SH groups from the body so that as a result of this, a higher toxocity is observed.
mesh_terms: D000821:Animal Feed; D000818:Animals; D005503:Food Additives; D005971:Glutamates / Q000008:administration & dosage*; D005998:Glycine / Q000008:administration & dosage*; D008715:Methionine / Q000378:metabolism*; D051381:Rats; D012694:Serine / Q000008:administration & dosage*; D013912:Threonine / Q000008:administration & dosage*
chemical_list: D005503:Food Additives; D005971:Glutamates; D013912:Threonine; D012694:Serine; D008715:Methionine; D005998:Glycine
vernacular_title: Untersuchungen zur Beeinflussung einer Methioninimbalanz bei Ratten durch Zulagen von Threonin, Serin, Glyzin oder Glutaminsäure