Influence of a long or medium chain triglyceride diet on intermediary hepatic metabolism of the rat.
Two groups of rats were given, ad libitum, diets containing 20% fat for 4-5 weeks. The fat consisted of either long chain (LCT) or medium chain triglycerides (MCT). A third group of rats was given a low fat control diet. No difference in weight increase could be found between LCT and MCT rats. Total lipids and cholesterol concentrations in the plasma were the same whatever the diet. The high fat diets caused an increase in hepatic acetyl-CoA, citrate, malate and ketone body concentrations. Concentration of ketone bodies in the blood, however, decreased. No ketonuria occurred in any case. Hepatic levels of adenosine 5'-triphosphate, adenosine 5'-monophosphate and inoganic phosphate seemed higher in MCT rats than in LCT rats. The levels of these substrates were increased in both groups compared with the control group. LCT rats had hepatic (NS) and blood (HS) lactate and pyruvate concentrations below the corresponding figures for control rats. Hepatic and blood lactate concentrations in MCT rats were at least equal to or slightly higher (NS) than those of control rats. Hepatic glucose and glycogen and blood glucose concentrations were higher in rats given the high fat diet.
D000105:Acetyl Coenzyme A / Q000378:metabolism; D000249:Adenosine Monophosphate / Q000378:metabolism; D000255:Adenosine Triphosphate / Q000378:metabolism; D000818:Animals; D001835:Body Weight / Q000187:drug effects; D002784:Cholesterol / Q000097:blood; D002951:Citrates / Q000378:metabolism; D004041:Dietary Fats; D005947:Glucose / Q000378:metabolism; D006003:Glycogen / Q000378:metabolism; D007657:Ketone Bodies / Q000097:blood / Q000378:metabolism; D007773:Lactates / Q000378:metabolism; D008055:Lipids / Q000097:blood; D008099:Liver / Q000187:drug effects / Q000378:metabolism*; D008293:Malates / Q000378:metabolism; D008297:Male; D010710:Phosphates / Q000378:metabolism; D011773:Pyruvates / Q000378:metabolism; D051381:Rats; D014280:Triglycerides / Q000494:pharmacology*
D002951:Citrates; D004041:Dietary Fats; D007657:Ketone Bodies; D007773:Lactates; D008055:Lipids; D008293:Malates; D010710:Phosphates; D011773:Pyruvates; D014280:Triglycerides; D000249:Adenosine Monophosphate; D000105:Acetyl Coenzyme A; D000255:Adenosine Triphosphate; D006003:Glycogen; D002784:Cholesterol; D005947:Glucose