The antipyretic effect of suprofen in rats with yeast-induced fever.
The antipyretic activity of alpha-methyl--4-(2-thienylcarbonyl)benzeneacetic acid (suprofen) was studied in rats with comparable hyperthermia after s.c. injection of brewer's yeast. The lowest dose effectively reducing fever is 5 mg/kg and restoration of normal body temperature is obtained with 40 mg/kg. Hypothermia is not observed even after treatment with 160 mg/kg. The ED50 (with confidence limits), which reduces fever below 39 degrees C in 50% of the animals, at the time of peak hyperthermia is 10.0 (6.6--15.2) mg/kg. ED50's of simultaneously studied reference compounds are 5.7 (3.9--8.3) mg/kg for indometacin, 38 (24--61) mg/kg for tolmetin, 76 (47--121) mg/kg for phenylburazone and 113 (75--170) mg/kg for acetyl-salicylic acid. Two to four times higher doses of these compounds restore normal body temperature but further increase of the dose induces hypothermia, which is particularly pronounced for acetyl-salicylic acid and phenylbutazone. Suprofen is a potent antipyretic agent, devoid of hypothermic activity even at 32 times the lowest effective dose.
D000700:Analgesics / Q000627:therapeutic use*; D000818:Animals; D001241:Aspirin / Q000627:therapeutic use; D001831:Body Temperature; D004305:Dose-Response Relationship, Drug; D004353:Drug Evaluation, Preclinical; D005334:Fever / Q000188:drug therapy* / Q000209:etiology; D007213:Indomethacin / Q000627:therapeutic use; D008297:Male; D010653:Phenylbutazone / Q000627:therapeutic use; D010666:Phenylpropionates / Q000627:therapeutic use*; D051381:Rats; D013876:Thiophenes / Q000627:therapeutic use*; D013997:Time Factors; D014046:Tolmetin / Q000627:therapeutic use; D015002:Yeast, Dried
D000700:Analgesics; D010666:Phenylpropionates; D013876:Thiophenes; D014046:Tolmetin; D010653:Phenylbutazone; D001241:Aspirin; D007213:Indomethacin