[Action of heliomycin on the incorporation of labelled protein precursors and nucleic acid in Staphylococcus aureus cells].
In concentrations of 0.05-0.10 gamma/ml geliomycin suppresses inclusion of C14-uracyl into the acid-soluble fractions of the staphylococcal cells. Inclusion of C14-leucine at the same concentrations of the antibiotics was suppressed to a lesser extent. The above concentrations of geliomycin had practically no effect on inclusion of C14-thimine. Suppression of C14-uracyl inclusion was observed in 5 minutes of the cell incubation with the antibiotic, a significant decrease in C14-leucine inclusion being observed only in 30 minutes of the incubation. The effect of geliomycin on the staphylococcal cells within the concentrations inhibiting the microbial growth and suppressing inclusion of labeled uracyl and leucine into the cells was of the bacteriostatic nature. It was supposed that the antibacterial effect of geliomycin was based on suppression of RNA synthesis.
D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D002250:Carbon Radioisotopes; D004269:DNA, Bacterial / Q000037:antagonists & inhibitors*; D003864:Depression, Chemical; D004305:Dose-Response Relationship, Drug; D007783:Lactones; D007930:Leucine / Q000037:antagonists & inhibitors; D011498:Protein Precursors / Q000037:antagonists & inhibitors*; D012329:RNA, Bacterial / Q000037:antagonists & inhibitors*; D013211:Staphylococcus aureus / Q000187:drug effects* / Q000378:metabolism; D013941:Thymine / Q000037:antagonists & inhibitors; D013997:Time Factors; D014498:Uracil / Q000037:antagonists & inhibitors
D000900:Anti-Bacterial Agents; D002250:Carbon Radioisotopes; D004269:DNA, Bacterial; D007783:Lactones; D011498:Protein Precursors; D012329:RNA, Bacterial; D014498:Uracil; D007930:Leucine; D013941:Thymine
Deĭstvie geliomitsina na vkliuchenie mechenykh predshestvennikov belka i nukleinovykh kislot v kletki Staphylococcus aureus