Allergic contact dermatitis from phenoxybenzamine hydrochloride: cross-sensitivity to some related haloalkylamine compounds.
Contact dermatitis from phenoxybenzamine hydrochloride occurred in a woman laboratory technician. Sensitization to this chemical was produced in guinea-pigs. Cross-sensitivity to related compounds may be due to the chloroethylamine moiety of the molecule. No cross-sensitivity was observed to the dichlorodiethylamine compound, nitrogen mustard.
D000328:Adult; D000818:Animals; D003877:Dermatitis, Contact / Q000175:diagnosis / Q000209:etiology*; D005021:Ethylamines / Q000009:adverse effects; D005260:Female; D006168:Guinea Pigs; D006801:Humans; D008466:Mechlorethamine / Q000009:adverse effects; D010328:Patch Tests; D010643:Phenoxybenzamine / Q000009:adverse effects* / Q000031:analogs & derivatives
D005021:Ethylamines; D010643:Phenoxybenzamine; D008466:Mechlorethamine