[Comparative study of the relationship between the blood concentration of gentamicin and streptomycin and their muscle-relaxing activity].
A mathematical model of relation between the miorelaxant effect value of aminocyclitol antibiotics and their blood levels is proposed. The kinetics of the reduction of the neuromuscle transmission damaged under the action of the drugs was studied in detail in acute experiments with cats treated with gentamycin or streptomycin administered intravenously. The changes in the effect value in time were satisfactorily described by the logistic function. Parallel determination of the blood levels of the antibiotics in the animals provided construction of an adequate model of their pharmacokinetics. Tabulation of the corresponding biexponential equations and logistic functions for the same time intervals during reduction of the neuromuscle transmission provided necessary information for plotting the "effect: concentration" curves. Comparison of the drug levels at which the effect of inhibition of the neuromuscle transmission was equal to 50% of the maximum one, revealed a statistically reliable difference in the miorelaxant activity of gentamycin and streptomycin. A high miorelaxant activity of gentamycin in comparison to streptomycin was also shown on comparison of the average "effect: concentration" curves plotted on the basis of tabulation of the general equations presenting a combination of the logistic and biexponential equations.
D000818:Animals; D002415:Cats; D004305:Dose-Response Relationship, Drug; D005839:Gentamicins / Q000097:blood*; D007700:Kinetics; D008433:Mathematics; D009125:Muscle Relaxants, Central / Q000097:blood*; D009431:Neural Conduction / Q000187:drug effects; D013307:Streptomycin / Q000097:blood*; D013997:Time Factors
D005839:Gentamicins; D009125:Muscle Relaxants, Central; D013307:Streptomycin
Sravnitel'noe izuchenie zavisimosti mezhdu kontsentratsieĭ gentamitsina i streptomitsina v krovi i ikh miorelaksantnoĭ aktivnost'iu