[Effect of the diuretic diacarb on the antitumor activity of the antibiotics rubomycin and olivomycin].
Combined use of rubomycin and olivomycin with diacarb in treatment of rats with Pliss lymphosarcoma increased the antiblastomic activity of the antibiotics. The antitumor effect of rubomycin and olivomycin was increased by diacarb in the same degree as that of dipin, a synthetic cytostatic.
D000818:Animals; D000903:Antibiotics, Antineoplastic / Q000494:pharmacology*; D004232:Diuretics / Q000494:pharmacology*; D004347:Drug Interactions; D004357:Drug Synergism; D004359:Drug Therapy, Combination; D005260:Female; D008228:Lymphoma, Non-Hodgkin / Q000188:drug therapy; D009368:Neoplasm Transplantation; D009848:Olivomycins / Q000494:pharmacology*; D010879:Piperazines / Q000494:pharmacology; D051381:Rats; D012878:Skin Neoplasms / Q000188:drug therapy; D013997:Time Factors
D000903:Antibiotics, Antineoplastic; D004232:Diuretics; D010879:Piperazines; D009848:Olivomycins
Vliianie diuretika diakarba na protivoopukholevuiu aktivnost' antibiotikov rubomitsina i olivomitsina