title: Sialoadenosis produced by drug-treatment of hypertonicity. II. Experimental studies on the effects of guanethidine (Ismelin) on the submaxillary glands of the rat.
abstract: 48 rats were treated with guanethidine (Ismelin) in order to study the side-effects on the submaxillary glands following application of a routinely used antihypertensive substance. In contrast to guanethidine-treated parotid glands, no retention of alpha-amylase was observed. The amylolytic activities of the glands are decreased both after treatment for 24 hrs and when a 3 week treatment had been followed by a 2 week recuperation period. This decrease of total amylase content runs parallel with alterations in the alpha-isoamylase patterns of the submaxillary glands. Furthermore, gland growth is inhibited by the guanethidine-mediated "pharmacological sympathectomy". We interpret these proteodyschylic changes of the submaxillary glands as a pharmacologically induced peripheral neurogenic sialoadenosis.
mesh_terms: D000681:Amylases / Q000378:metabolism; D000818:Animals; D005260:Female; D006145:Guanethidine / Q000009:adverse effects* / Q000494:pharmacology; D007517:Isoamylase / Q000378:metabolism; D051381:Rats; D012466:Salivary Gland Diseases / Q000139:chemically induced*; D013363:Submandibular Gland / Q000187:drug effects / Q000201:enzymology / Q000254:growth & development
chemical_list: D000681:Amylases; D007517:Isoamylase; D006145:Guanethidine