[Stimulation of fibrillogenesis in granulation tissue].
RNA synthesis by fibroblasts in healing wounds of mice and passage of the newly-formed RNA from the nucleus into the cytoplasm were studied in control mice and those treated by potassium orotate. Potassium orotate accelerated the passage of the RNA from the nucleus into the cytoplasm of the fibroblasts. Formation and maturation of the collagen fibrils in the wounds were studied by scanning electron microscope.
D000818:Animals; D003094:Collagen / Q000096:biosynthesis; D006097:Granulation Tissue / Q000187:drug effects / Q000378:metabolism; D051379:Mice; D009963:Orotic Acid / Q000494:pharmacology*; D012313:RNA / Q000096:biosynthesis; D012867:Skin / Q000293:injuries*; D013268:Stimulation, Chemical; D014945:Wound Healing / Q000187:drug effects*
D009963:Orotic Acid; D012313:RNA; D003094:Collagen
Stimuliatsiia fibrillogeneza v granuliatsionnoĭ tkani