Effect of 2-thiourea administered to pregnant rats on the thyroid and the protein bound iodine content of the offspring.
A 0.2% solution of 2-thiourea administered during the third or the second and third weeks of pregnancy increased the weight of the thyroid of 20-day old fetuses and newborn rats, and decreased the protein bound iodine content in their thyroid and serum. Similar changes were observed in those weanling rats whose mother had been given a 0.2% solution of thiourea during the period of lactation. Both the intrauterine changes and those occurring during lactation proved reversible. The findings point to the possibility of congenital or infantile thyroid injury caused by thiourea derivatives taken up from the environment.
D000818:Animals; D000831:Animals, Newborn; D001798:Blood Proteins; D005260:Female; D007455:Iodine / Q000097:blood*; D008431:Maternal-Fetal Exchange; D009929:Organ Size; D011247:Pregnancy; D011485:Protein Binding / Q000187:drug effects; D051381:Rats; D013890:Thiourea / Q000009:adverse effects / Q000494:pharmacology*; D013959:Thyroid Diseases / Q000139:chemically induced; D013961:Thyroid Gland / Q000033:anatomy & histology / Q000187:drug effects* / Q000378:metabolism
D001798:Blood Proteins; D007455:Iodine; D013890:Thiourea