[2,2-Hydrazinopyrimidines with branched substituents as potential antitumor agents. Condensation with hydrazine-N,N-dicarboxamidine].
With a view to the cytostatic effect exhibited by certain representatives of the 2,2'-hydrazopyrimidines on the one hand, and by various drugs carrying branched substituents on the other hand, 4,4',6,6'-tetra-tert.-butyl-2,2'-hydrazopyrimidine (III) has been prepared by condensation of 1,2-hydrazine-dicarboxamidine (I) with 2,2,6,6-tetramethyl-3,5-heptanedione (II). Structure III has been confirmed by IR and NMR data and by its N,N'-diacetyl derivative IV.
D000970:Antineoplastic Agents / Q000138:chemical synthesis*; D006834:Hydrazines / Q000138:chemical synthesis*; D009682:Magnetic Resonance Spectroscopy; D011743:Pyrimidines / Q000138:chemical synthesis*; D013055:Spectrophotometry, Infrared
D000970:Antineoplastic Agents; D006834:Hydrazines; D011743:Pyrimidines
Verzweigketting substituierte 2,2'-Hydrazopyrimidine als potentielle Tumorhemmer. Kondensationen mit Hydrazine-N,N'-dicarbonsäure-diamidin