Further studies on prostaglandins. III. Effect of prostaglandins on thyroid activity as assessed by 125I.
The effect of crude prostaglandins extraced from prostate glands of camels as well as that PGE1, on the thyroid activity of male immature Boskat rabbits, was investigated. The iodinated amino acid fractions (T1, T2, T3 and T4) in the serum of the injected groups were determined in control and treated animals. Cytological work on sections of the thyroid glands of the treated and control rabbits were performed to study the effect on subcellular level. The results indicate that both crude and pure prostaglandins have a stimulating effect on thyroid activity. This was indicated by the increased 125I uptake of the thyroids of rabbits and evidenced histologically. PGE1, was found to be more effective as compared with the crude prostaglandins. The indinated amino acid and hormone fractions in the serum of the treated groups showed that T2 was increased as a result of injection of the crude prostaglandins, and T4 was increased after PGE1 injection. Tables and figures explained diversed effect.
D000818:Animals; D007457:Iodine Radioisotopes; D011453:Prostaglandins / Q000494:pharmacology*; D011458:Prostaglandins E / Q000494:pharmacology; D011817:Rabbits; D013961:Thyroid Gland / Q000187:drug effects* / Q000378:metabolism
D007457:Iodine Radioisotopes; D011453:Prostaglandins; D011458:Prostaglandins E