A comparison of the effects of halothane and other anaesthetic agents on hepato-cellular function in patients submitted to elective operations.
In an attempt to gather objective evidence of possible hepato-cellular toxicity of the halogenated anaesthetics halothane and methoxyflurane pre-operative and post-operative enzyme estimations were done on patients admitted for elective operations. The series of approximately 500 cases included 160 patients submitted to cholecystectomy, an operation associated with a high percentage of detectable alteration of hepatocellular function in the post-operative period. There was no significant difference between the groups of patients receiving halothane, methoxyflurane, or nitrous oxide and oxygen with analgesic supplement. The magnitude of the increased post-operative enzyme activity and the post-operative temperature elevation were not significantly different in the three groups studied.
D000293:Adolescent; D000328:Adult; D000368:Aged; D000769:Anesthesia, Inhalation; D001123:Argininosuccinate Lyase / Q000097:blood; D002763:Cholecystectomy; D004798:Enzymes / Q000097:blood; D005260:Female; D006221:Halothane / Q000494:pharmacology*; D006801:Humans; D008099:Liver / Q000187:drug effects* / Q000503:physiopathology; D008111:Liver Function Tests; D008297:Male; D008875:Middle Aged
D004798:Enzymes; D001123:Argininosuccinate Lyase; D006221:Halothane