title: Inhibition of measles virus replication and enhancement of cellular DNA synthesis in vero cells by ribavirin, an antiviral and antineoplastic drug.
abstract: Excellent in vitro inhibition of measles virus infectivity by ribavirin was detectable by a tube method allowing prolonged maintenance which makes possible the evaluation of efficiency at daily intervals. Optimal efficiency occurred on day 5 to 7, depending on the drug dose. Although syntheses of cellular RNA and protein were inhibited by low drug dosage, the de novo DNA synthesis was enhanced. Peak 4-fold enhancement resulted with 320 mug/ml after 2 days treatment.
mesh_terms: D002460:Cell Line; D004279:DNA, Viral / Q000096:biosynthesis*; D004305:Dose-Response Relationship, Drug; D008459:Measles virus / Q000378:metabolism*; D012367:RNA, Viral / Q000096:biosynthesis; D012254:Ribavirin / Q000494:pharmacology*; D012263:Ribonucleosides / Q000494:pharmacology*; D014764:Viral Proteins / Q000096:biosynthesis; D014779:Virus Replication / Q000187:drug effects*
chemical_list: D004279:DNA, Viral; D012367:RNA, Viral; D012263:Ribonucleosides; D014764:Viral Proteins; D012254:Ribavirin