Influence of dopamine-like compounds on stereotypy and locomotor activity in atropinized rats.
The influence of atropine on stimulation of exploratory activity, locomotor activity and stereotypy in rats treated with compounds which stimulate central dopamine receptors (apomorphine, D-amphetamine, D-145 and piribedil) was studied. Atropine potentiated the action of these compounds in some experimental systems. The results are discussed from the point of view of an equilibrium between the dopaminergic and cholinergic systems in the central nervous system.
D000818:Animals; D001058:Apomorphine / Q000494:pharmacology; D001285:Atropine / Q000494:pharmacology*; D001519:Behavior / Q000187:drug effects*; D004298:Dopamine / Q000494:pharmacology* / Q000502:physiology; D005106:Exploratory Behavior / Q000187:drug effects; D006801:Humans; D009043:Motor Activity / Q000187:drug effects*; D010891:Piribedil / Q000494:pharmacology; D051381:Rats; D011955:Receptors, Drug / Q000187:drug effects; D013239:Stereotyped Behavior / Q000187:drug effects*
D011955:Receptors, Drug; D001285:Atropine; D010891:Piribedil; D001058:Apomorphine; D004298:Dopamine