title: [Thrombophlebitis following intravenous injection--an experimental study].
abstract: Thrombophlebitis similar to that which is frequently observed following i.v. injection of irritative drugs in clinical treatment has been successfully reproduced in experimental animals by utilizing a newly devised technique. Thrombophlebitis at a high rate resulted within a few days by allowing the sample to remain in the sealed section of the V. retroauricularis in rabbits for 3 min after injection. The effects of several drug preparations on the thrombus as well as on the inflammation formed by means of this technique were examined, and the results were in good parallel with clinical cases reported in medical literature. Histopathologically, it was observed that each thrombus was formed by the irritative effect of drugs on the portion on the veneous wall damaged when needles had been inserted.
mesh_terms: D000100:Acetrizoic Acid / Q000008:administration & dosage / Q000009:adverse effects; D000818:Animals; D004305:Dose-Response Relationship, Drug; D004423:Ear / Q000098:blood supply; D007275:Injections, Intravenous / Q000009:adverse effects*; D008297:Male; D008722:Methods; D011817:Rabbits; D013924:Thrombophlebitis / Q000209:etiology* / Q000473:pathology; D013997:Time Factors; D014680:Veins / Q000473:pathology
chemical_list: D000100:Acetrizoic Acid