Neutral sodium pump in the small intestine.
A non-electrogenic mechanism for Na absorption has been demonstrated in the in vitro short-circuited rat mid-jejunum. This mechanism exists in addition to the electrogenic Na absorption associated with active non-electrolyte transfer. It was not possible to demonstrate the existence of a similar mechanism in rat terminal ileum and it is suggested that this is related to differences in the metabolism of the ileum as compared with the jejunum. the neutrality of the non-electrogenic pump has been shown to be largely due to the absorption of Na accompanied by Cl. These appears to be a common link between the two types of Na pump since both are inhibited by ouabain although the non-electrogenic pump shows greater sensitivity to ouabain than the electrogenic pump.
D000818:Animals; D001693:Biological Transport, Active; D001826:Body Fluids / Q000378:metabolism; D005690:Galactose / Q000378:metabolism; D007082:Ileum / Q000378:metabolism; D066298:In Vitro Techniques; D007413:Intestinal Mucosa / Q000378:metabolism; D007421:Intestine, Small / Q000378:metabolism*; D007583:Jejunum / Q000378:metabolism; D008297:Male; D008358:Mannose / Q000494:pharmacology; D010042:Ouabain / Q000494:pharmacology; D051381:Rats; D012964:Sodium / Q000378:metabolism*; D013431:Sulfates / Q000494:pharmacology
D013431:Sulfates; D010042:Ouabain; D012964:Sodium; D008358:Mannose; D005690:Galactose