Effects of testing age and fostering experience on seizure susceptibility of rats treated prenatally with chlorpromazine.
Offspring of rats treated with 2 mg/kg body weight chlorpromazine (CPZ) on Days 5-8 of gestation had lower seizure thresholds than offspring of saline-treated controls at 30, 60, 90, and 120 days of age. The CPZ-treated offspring were also heavier than controls prior to weaning. Further analysis using cross-fostered litters indicated that at least part of the drug effect on seizure thresholds took place before birth, although a postnatal component was also demonstrated. A striking effect of the fostering experience itself on the seizure threshold prevented conclusions about the relative importance of prenatal and postnatal influences.
D000367:Age Factors; D000818:Animals; D000831:Animals, Newborn / Q000254:growth & development*; D001835:Body Weight / Q000187:drug effects; D002746:Chlorpromazine / Q000494:pharmacology*; D004056:Differential Threshold; D005260:Female; D005481:Flurothyl; D005865:Gestational Age; D008098:Litter Size / Q000187:drug effects; D008297:Male; D008431:Maternal-Fetal Exchange; D011247:Pregnancy; D051381:Rats; D011930:Reaction Time; D012640:Seizures / Q000139:chemically induced*; D012737:Sex Factors
D005481:Flurothyl; D002746:Chlorpromazine