Juvenile Cushing syndrome manifested primarily by growth failure.
An 11-year-old boy had Cushing syndrome with profound growth retardation, but without the associated clinical characteristics of the disease. Treatment with growth hormone failed to promote growth, suggesting that growth failure in the presence of excess glucocorticoids is due to peripheral tissue resistance to growth hormone rather than to impairment of growth hormone secretion.
D000293:Adolescent; D002648:Child; D003480:Cushing Syndrome / Q000097:blood / Q000150:complications* / Q000175:diagnosis; D005938:Glucocorticoids / Q000494:pharmacology; D006130:Growth Disorders / Q000209:etiology*; D013006:Growth Hormone / Q000097:blood; D006801:Humans; D008297:Male
D005938:Glucocorticoids; D013006:Growth Hormone