Experimental urinary stone formation following persorption.
The 'effect of Herbst' was combined with the production of renal calcium oxalate sediments by oral administration of ethyleneglycol and acidification with NH4Cl. This investigation was made to see whether persorbed bodies may form nuclei in crystallization in the genesis of stone. Lead sulphide crystals and 45Ca-labelled calcium oxalate crystals were used as persorbable model bodies. It became apparent that lead sulphide crystals given by mouth could be found both in the urine and kidneys, but these did not form nuclei in calcium oxalate sediments. Radioactive-labelled calcium, however, could be proved histoautoradiographically within the renal concretions. Our experiments showed that persorbed calcium oxalate crystals can represent nuclei for stone formation.
D000643:Ammonium Chloride / Q000009:adverse effects; D000818:Animals; D002118:Calcium / Q000652:urine; D005026:Ethylene Glycols / Q000009:adverse effects; D007408:Intestinal Absorption; D007668:Kidney / Q000473:pathology; D007854:Lead / Q000008:administration & dosage / Q000652:urine; D008297:Male; D010070:Oxalates / Q000652:urine; D051381:Rats; D013440:Sulfides / Q000008:administration & dosage / Q000652:urine; D014545:Urinary Calculi / Q000139:chemically induced / Q000473:pathology / Q000652:urine*
D005026:Ethylene Glycols; D010070:Oxalates; D013440:Sulfides; D000643:Ammonium Chloride; D007854:Lead; D002118:Calcium