[The effect of 0-methylhydroxylamine on the chromosomes of Chinese hamster cells].
0-methylhydroxylamine increases the frequency of all kinds of aberrations in Chinese hamster cells, except chromatid exchange. The percentage of aberrant metaphases and the average number of breakages per cell increases by 5,5-6 times as compared with the control. OMHA proves to be very effective inducer of chromosome aberrations. Since OMHA induces, except gene mutations, also chromosome aberrations, there are reasons to suppose that its effect is connected not only with transitions, but also with some other molecular mechanisms.
D000818:Animals; D002842:Chromatids / Q000187:drug effects; D002869:Chromosome Aberrations; D002875:Chromosomes / Q000187:drug effects*; D002999:Clone Cells; D006224:Cricetinae; D006898:Hydroxylamines / Q000494:pharmacology*
D006898:Hydroxylamines
Deĭstvie 0-metilgidroksilamina na khromosomy kletok kitaĭskogo khomiachka