title: Parathyroid activity and bone formation.
abstract: Patients of both sexes with primary hyperparathyroidism showed increments in the total subperiosteal diameter and the medullary cavity diameter of the second metacarpal bone. When two groups of females of similar age were compared, those with hyperparathyroidism had significantly greater total metacarpal area and medullary area than that of hypoparathyroid patients. An increased subperiosteal apposition has therefore been found in primary hyperparathyroidism. This might be due to a direct stimulation of PTH on bone formation at the subperiosteal surface or to a nonspecific compensatory response to endosteal resorption.
mesh_terms: D000293:Adolescent; D000328:Adult; D001846:Bone Development; D001862:Bone Resorption; D005260:Female; D006801:Humans; D006961:Hyperparathyroidism / Q000503:physiopathology*; D007011:Hypoparathyroidism / Q000503:physiopathology; D008297:Male; D008663:Metacarpus / Q000033:anatomy & histology; D008875:Middle Aged; D010280:Parathyroid Glands / Q000503:physiopathology*; D010281:Parathyroid Hormone / Q000494:pharmacology
chemical_list: D010281:Parathyroid Hormone