The effect of alpha-melanophor-stimulating hormone on liver regeneration and incorporation of amino acid in rats' liver protein.
Following 25 mug/day synthetic alpha-MSH administration, the liver regeneration of partially hepatectomized rats proved to be increased. The hormone treatment resulted in an enhanced alanine incorporation of the liver proteins, but this effect was uncertain on partially hepatectomized rats. Due to the hormone treatment the low liver protein content of the operated rats became normal. The pseudocholinesterase activity of the liver homogenate of alpha-MSH treated rats was also elevated. On the basis of these experiments authors are supposing some protein synthesis increasing effect of synthetic alpha-MSH.
D000409:Alanine / Q000378:metabolism; D000596:Amino Acids / Q000378:metabolism*; D000818:Animals; D002802:Cholinesterases / Q000378:metabolism; D006498:Hepatectomy; D008099:Liver / Q000187:drug effects* / Q000201:enzymology / Q000378:metabolism; D008115:Liver Regeneration / Q000187:drug effects*; D008297:Male; D009074:Melanocyte-Stimulating Hormones / Q000494:pharmacology*; D011506:Proteins / Q000378:metabolism*; D051381:Rats
D000596:Amino Acids; D011506:Proteins; D009074:Melanocyte-Stimulating Hormones; D002802:Cholinesterases; D000409:Alanine