Sinus histiocytosis with massive lymphadenopathy: fifteen new cases.
Fifteen cases of chronic lymphadenitis with massive hemophagocytic sinus histiocytosis were analyzed. Fourteen patients were whites, 13 were Europeans, and 11 were males; 10 patients were under 10, 4 were over 20, and 2 over 60 years old. The oldest patient died; all other either healed without therapy or are in excellent condition. We studied the cytologic features of lymph node imprints. A 5-year-old girl was examined more thoroughly. High antibody titers to Klebsiella antigens were found repeatedly. The patient also had a constant lymphocytopenia. Phytohemagglutinin-induced blast transformation and lymphotoxin production were within normal limits. No serum Epstein-Barr virus-antibodies could be detected.
D000293:Adolescent; D000328:Adult; D000368:Aged; D002648:Child; D002675:Child, Preschool; D005260:Female; D006644:Histiocytes; D006801:Humans; D007223:Infant; D007709:Klebsiella / Q000276:immunology; D008198:Lymph Nodes / Q000473:pathology; D008199:Lymphadenitis / Q000150:complications* / Q000276:immunology / Q000473:pathology; D008206:Lymphatic Diseases / Q000150:complications* / Q000276:immunology / Q000473:pathology; D008297:Male; D008875:Middle Aged