Myocardial and endocardial lesions in rabbit after acute poisoning with Intration and after treatment with some detoxifying agents.
The hearts of rabbits killed 24 hours after intoxication with Intration in the dose of LD50 and rabbits treated at the same time with PAM or atropine were studied pathomorphologically. Twenty-four hours after administration of Intration toxic lesions of the myocardium and endocardium were observed, which were more pronounced in rabbits treated simultaneously with the detoxifying agents as compared with those which received only Intration. The intensity of the changes was due to overdosage of the detoxifying agents, especially PAM which was particularly harmful.
D000818:Animals; D001285:Atropine / Q000009:adverse effects / Q000627:therapeutic use*; D004699:Endocardium / Q000473:pathology*; D006321:Heart / Q000187:drug effects; D007306:Insecticides / Q000506:poisoning*; D009206:Myocardium / Q000473:pathology*; D009336:Necrosis; D009946:Organothiophosphorus Compounds; D011220:Pralidoxime Compounds / Q000009:adverse effects / Q000627:therapeutic use*; D011817:Rabbits
D007306:Insecticides; D009946:Organothiophosphorus Compounds; D011220:Pralidoxime Compounds; D001285:Atropine