Distribution of coronary collateral flow in acute myocardial ischaemic injury: effect of propranolol.
The local distribution of coronary collateral flow was mapped using 8 mu tracer microspheres following circumflex coronary occlusions in dogs. Overall flow to the ischaemic posterior papillary muscle and subjacent myocardium decreased to 21% of anterior free wall flow. Collateral flow was non-uniform, however, and was lower in the subendocardium (14%) than in the subepicardium (27%). Brief temporary occlusions with and without propranolol therapy showed that collateral flow was less and the inner/outer wall ratio was unaltered in treated animals. Although propranolol reduces infarct size after coronary occlusions, this effect appears not to be related to increases in collateral flow.
D000208:Acute Disease; D000818:Animals; D003097:Collateral Circulation / Q000187:drug effects*; D004396:Coloring Agents / Q000378:metabolism; D003327:Coronary Disease / Q000378:metabolism / Q000503:physiopathology*; D004285:Dogs; D005260:Female; D006439:Hemodynamics / Q000187:drug effects; D008297:Male; D008863:Microspheres; D009206:Myocardium / Q000378:metabolism; D011433:Propranolol / Q000494:pharmacology*
D004396:Coloring Agents; D011433:Propranolol