[Effect of chloridine on some biochemical indices in pregnant rats].
Experiments conducted on rats demonstrated that introduction of chloridine (35 mg/kg) on the 13th day of gestation causes maldevelopment of the fetuses in 81.5 per cent of the cases. The blood serum of female-rats receiving the teratogenic compound showed a change in the content of the pre-albuminic and albuminic fractions, the appearance of an unusual proteinic band in the beta-globulins zone and also perversion of the isoenzymatic spectrum of the serumal lactate-dehydrogenase, as well as a 2.9-fold increase of its specific activity.
D000014:Abnormalities, Drug-Induced / Q000453:epidemiology; D000818:Animals; D001798:Blood Proteins / Q000032:analysis; D004789:Enzyme Activation / Q000187:drug effects; D005260:Female; D005333:Fetus / Q000187:drug effects; D007527:Isoenzymes; D007770:L-Lactate Dehydrogenase / Q000097:blood; D008099:Liver / Q000187:drug effects; D011228:Prealbumin / Q000032:analysis; D011247:Pregnancy; D011270:Pregnancy, Animal / Q000187:drug effects*; D011506:Proteins / Q000032:analysis; D011739:Pyrimethamine / Q000494:pharmacology*; D051381:Rats; D012712:Serum Globulins / Q000032:analysis; D013997:Time Factors
D001798:Blood Proteins; D007527:Isoenzymes; D011228:Prealbumin; D011506:Proteins; D012712:Serum Globulins; D007770:L-Lactate Dehydrogenase; D011739:Pyrimethamine
Vliianie khloridina na nekotorye biokhimicheskie pokazateli u beremennykh krys