The kinetics of the interaction of heterologous anti-tumor serum and heterologous complement in non-tumor bearing mice.
The persistence of heterologous antitumor serum in the periphery of normal, non-tumor bearing mice was analyzed following intravenous, intraperitoneal, and subcutaneous injection. Intravenous injection of guinea pig complement subsequent to antibody administration resulted in the immediate disappearance of tumor-specific antibody from the periphery. Such studies suggest that appropriate therapy by the passive administration of antiserum requires the initial administration of antibody to allow for preferential binding to tumor-specific antigens followed by the subsequent injection of complement to mediate tumor cytolysis.
D000818:Animals; D000912:Antibodies, Neoplasm / Q000032:analysis; D001666:Binding Sites, Antibody; D003165:Complement System Proteins / Q000032:analysis; D007106:Immune Sera; D008297:Male; D051379:Mice; D009369:Neoplasms / Q000628:therapy
D000912:Antibodies, Neoplasm; D007106:Immune Sera; D003165:Complement System Proteins