[Joint action of nitrofuran preparations and bile acids on bacteria of the genus Proteus].
Sensitivity of 25 fresh isolates of Proteus to some nitrofuran drugs most widely used in the clinical practice, such as furacillin, furagin, furazolidone and nitrofurantoin was studied. When the drugs were used in combination with some bile acids, i.e. desoxycholic, dehydrocholic, cholic and glycocholic acids, significant in vitro potentiation of the antibacterial activity of the nitrofurans against the isolates was observed. The combinations of the drugs with desoxycholic acid proved to be most effective. In the presence of this acid the bacteriostatic dose of the drugs decreased several thousand times. Combination of the nitrofurans with the other acids resulted in an increase in the antimicrobial activity amounting to several hundred times. The combinations of the drugs with the bile acids had not only bacteriostatic but also bactericidal effect.
D001647:Bile Acids and Salts / Q000494:pharmacology*; D004338:Drug Combinations; D004357:Drug Synergism; D008826:Microbial Sensitivity Tests; D009581:Nitrofurans / Q000494:pharmacology*; D011511:Proteus / Q000187:drug effects*
D001647:Bile Acids and Salts; D004338:Drug Combinations; D009581:Nitrofurans
Sovmestnoe deĭstvie nitrofuranovykh preparatov i zhelchnykh kislot na bakterii iz roda proteia