Luteal 20alpha-hydroxy steroid dehydrogenase and the formation of delta4-3-oxo steroids in the rat after weaning or treatment with 2-bromo-alpha-ergocryptine during lactation.
Natural or early weaning of rat litters caused an increased activity of maternal luteal 20alpha-hydroxy steroid dehydrogenase and a decreased release of delta4-3-oxo steroids in vitro. 2. Compound CB-154 (2-bromo-alpha-ergocryptine) caused an increase of 20alpha-hydroxy steroid dehydrogenase activity in mid-lactation but not in early lactation. 3. Prolaction did not prevent these increases in enzyme activity.
D000315:Adrenalectomy; D000818:Animals; D001971:Bromocriptine / Q000494:pharmacology*; D003338:Corpus Luteum / Q000201:enzymology; D004873:Ergolines / Q000494:pharmacology*; D005260:Female; D006913:Hydroxysteroid Dehydrogenases / Q000378:metabolism; D007664:Ketosteroids / Q000096:biosynthesis; D007774:Lactation / Q000187:drug effects*; D010053:Ovary / Q000187:drug effects; D011247:Pregnancy; D011388:Prolactin / Q000494:pharmacology; D051381:Rats; D013997:Time Factors; D014886:Weaning
D004873:Ergolines; D007664:Ketosteroids; D001971:Bromocriptine; D011388:Prolactin; D006913:Hydroxysteroid Dehydrogenases