[Test for hypocalcemia due to calcitonin in the normal subject and in patients with osteoporosis or Paget's disease. Preliminary results].
The authors report the variations in calcaemia and in circulating immunoreactive PTH produced by the intramuscular injection of 5 units of porcine calcitonin in normal subjects and in patients suffering from osteoporosis or Paget's disease. After having determined the levels of 25-hydroxy-vitamin D circulating in the different groups, the authors note that comparison of these variations makes it possible to regroup the different types of reaction following the injection of the hypocalcaemic hormone. In patients suffering from pure osteoporosis, hypocalcaemia was slow to appear, was of moderate intensity, but was prolonged. The osteoporo-malacia patients did not produce a specific reaction and certain of them appeared "insensitive" to calcitonin. Results obtained in patients with Paget's disease confirm the hypocalaemic action of calcitonin even at a low dosage. With this test, the authors hope to contribute to studies of demineralizing affections and to overcoming them.
D000328:Adult; D002116:Calcitonin / Q000494:pharmacology*; D003348:Cortisone / Q000009:adverse effects; D006801:Humans; D006996:Hypocalcemia / Q000139:chemically induced*; D008297:Male; D010001:Osteitis Deformans / Q000378:metabolism*; D010024:Osteoporosis / Q000139:chemically induced / Q000378:metabolism*
D002116:Calcitonin; D003348:Cortisone
Le test d'hypocalcémie provoquée par la calcitonine chez le sujet normal, et chez des sujets atteints d'ostéoporose ou de maladie de Paget