Regulation of plasma free 5-hydroxytryptamine level.
In this study we investigated the mechanisms which control the level of free 5-hydroxytryptamine in plasma. Results indicate that both degradation by monoamineoxidase and uptake by platelets are important for this control. On the other hand, results show that an increase of plasma free 5-HT induces cardiovascular disorders.
D000818:Animals; D001792:Blood Platelets / Q000378:metabolism; D004285:Dogs; D006321:Heart / Q000187:drug effects; D006897:Hydroxyindoleacetic Acid / Q000097:blood*; D010042:Ouabain / Q000494:pharmacology; D012701:Serotonin / Q000097:blood* / Q000494:pharmacology
D012701:Serotonin; D006897:Hydroxyindoleacetic Acid; D010042:Ouabain