Serotonin (5HT) systems in psychotic states.
Lumbar cerebrospinal fluid (CSF) 5-hydroxyindoleacetic acid (5HIAA) following probenecid was negatively correlated with prognostic variables in a group of schizophrenic patients. Acute schizophrenic patients had lower CSF 5HIIA was negatively correlated with measured activity and rated agitation in a mixed group of schizophrenic patients. There is compelling evidence that LSD directly inhibits the firing of serotonergic neurons. Individuals who developed prolonged psychotic reactions following LSD ingestion had relatively good premorbid trait histories and a family history of psychosis in 33% of cases compared to 21% for non drug-induced psychotic patients. If central serotonin system in man are mainly inhibitory, our results are consistent with the hypothesis that in some acute psychotic states a primary decreases in sertonergic neuronal activity may contribute to excessive central nervous system arousal.
D006719:Homovanillic Acid / Q000134:cerebrospinal fluid; D006801:Humans; D006897:Hydroxyindoleacetic Acid / Q000134:cerebrospinal fluid; D011339:Probenecid / Q000627:therapeutic use; D011618:Psychotic Disorders / Q000134:cerebrospinal fluid / Q000188:drug therapy / Q000503:physiopathology*; D012701:Serotonin / Q000502:physiology*; D013997:Time Factors
D012701:Serotonin; D006897:Hydroxyindoleacetic Acid; D011339:Probenecid; D006719:Homovanillic Acid