Some cerebral proteins and enzyme systems in Alzheimer's presenile and senile dementia.
The water-soluble proteins of the cerebral gray matter and some enzyme systems (cholinesterase, acetylcholinesterase, lactate dehydrogenase, malate dehydrogenase, acid phosphatase) were studied in 9 autopsy cases of Alzheimer's presenile or senile dementia, 1 case of Pick's disease and 1 case of cerebral arteriosclerosis. The proteins and enzyme patterns were visualized on polyacrylamide gradient gels after electrophoresis. In all patients studied, the profiles of cerebral gray-matter proteins were normal. In the patients with advanced dementia, the enzyme patterns usually were abnormal. Particularly in Alzheimer's disease, the activity of malate dehydrogenase was markedly increased.
D000110:Acetylcholinesterase / Q000378:metabolism*; D000135:Acid Phosphatase / Q000378:metabolism*; D000368:Aged; D000544:Alzheimer Disease / Q000201:enzymology / Q000378:metabolism*; D001921:Brain / Q000201:enzymology*; D001923:Brain Chemistry; D002802:Cholinesterases / Q000378:metabolism*; D003704:Dementia / Q000201:enzymology / Q000378:metabolism*; D005260:Female; D006801:Humans; D002537:Intracranial Arteriosclerosis / Q000201:enzymology / Q000378:metabolism; D007770:L-Lactate Dehydrogenase / Q000378:metabolism*; D008291:Malate Dehydrogenase / Q000378:metabolism*; D008297:Male; D009419:Nerve Tissue Proteins / Q000378:metabolism*
D009419:Nerve Tissue Proteins; D007770:L-Lactate Dehydrogenase; D008291:Malate Dehydrogenase; D000110:Acetylcholinesterase; D002802:Cholinesterases; D000135:Acid Phosphatase