title: Effect of aluminum upon conditioned avoidance response acquisition in the absence of neurofibrillary degeneration.
abstract: Aluminum induces neurofibrillary degeneration in cats but not rats. Cats develop a progressive encephalopathy in which an early manifestation is impaired learning-memory performance. At brain aluminum concentrations of 5 to 6 times that found in cat, rats demonstrate an initial transient weight loss and acquisition deficit immediately following intracranial injection. However, rats do not develop a progressive encephalopathy or a chronic learning deficit.
mesh_terms: D000535:Aluminum / Q000032:analysis / Q000494:pharmacology*; D000818:Animals; D001362:Avoidance Learning / Q000187:drug effects*; D001835:Body Weight / Q000187:drug effects; D001921:Brain / Q000033:anatomy & histology; D001923:Brain Chemistry; D003864:Depression, Chemical; D008297:Male; D009410:Nerve Degeneration; D051381:Rats
chemical_list: D000535:Aluminum