title: [Generalized mycobacterium avium infection in an infant (author's transl)].
abstract: In a 3-year-old girl, who was admitted to our hospital with marked splenomegaly, a swollen abdomen and progressive loss of weight, the difficulty in establishing the correct diagnosis, namely a very rare generalized infection with Mycobacterium avium (serum type III), and the lengthy course of the disease are demonstrated. Norcardiosis, sarcoidosis and BCG-granulomatosis were excluded. From the spleen, lymphatic nodes, gastric juice, stools and urine of the child, who had not been vaccinated with BCG vaccine, masses of acid-fast bacilli were isolated. The generalisation of the disease was promoted by an immunological deficiency. At autopsy an atrophic thymus was discovered. The extensive clinical and immunological investigations pointed to a partial deficiency of the cell-mediated immune systeme. The patient died 8 months after admission.
mesh_terms: D000740:Anemia / Q000209:etiology; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007153:Immunologic Deficiency Syndromes / Q000150:complications; D009161:Mycobacterium / Q000302:isolation & purification*; D009164:Mycobacterium Infections / Q000209:etiology / Q000382:microbiology*; D009162:Mycobacterium avium / Q000302:isolation & purification*; D013163:Splenomegaly / Q000209:etiology
vernacular_title: Generalisierte Mycobacterium avium-Infektion bei einem Kleinkind