Ultramicroscopic investigations of the exocrine pancreas of the dog after vagotomy.
The exocrine pancreas of 20 dogs was investigated electron microscopically before and 3, 4, 10, 11 and 14 days after bilateral truncular vagotomy. Up to the tenth day of the experiment a disturbance of the secretion of the acinar cells could be found with a sustained increase in enzyme protein synthesizing and lysosomal activity, irregular formation of zymogen granules and probably continuous extrusion of the enzyme proteins. The possible regulation mechanisms after vagotomy are discussed.
D000818:Animals; D004285:Dogs; D010179:Pancreas / Q000648:ultrastructure*; D010437:Peptic Ulcer / Q000601:surgery; D013997:Time Factors; D014628:Vagotomy