title: Clinical pharmacology and pharmacokinetics of clonidine.
abstract: A 300-mug oral dose of clonidine was administered to 5 normal volunteers and measurements of plasma concentration and effects upon blood pressure, heart rate, circulatory reflexes, sedation, and dry mouth were made for the following 8 hr. The plasma concentration rose to a peak of 1.02 +/- 0.52 ng/ml (SD) at 90 min and fell with a mean half-life of 12.7 hr. Blood pressure of the group fell from 111.0/77.0 to 87.2/60.4 after 3 hr and was 95.2/62.2 mm Hg at 8 hr. Heart rate in recumbency was slowed. Marked sedation and a fall in salivary flow followed the same time-course as the plasma concentration. The cold pressor response was reduced but the Valsalva overshoot was little affected.
mesh_terms: D000328:Adult; D001794:Blood Pressure / Q000187:drug effects; D003000:Clonidine / Q000097:blood / Q000494:pharmacology*; D006801:Humans; D006993:Hypnotics and Sedatives; D007700:Kinetics; D008297:Male; D011674:Pulse / Q000187:drug effects; D012472:Salivation / Q000187:drug effects; D013997:Time Factors; D014636:Valsalva Maneuver
chemical_list: D006993:Hypnotics and Sedatives; D003000:Clonidine