Effects of intravenous infusion of mimosine on wool growth of Merino sheep.
Merino sheep were given continuous intravenous infusions of L-mimosine for periods of 1 1/2, 2 or 21 days; efficacy as a defleecing procedure and effects on subsequent wool growth were measured. In addition, the amino acids tyrosine, phenylalanine and cystine were investigates as antagonists to the effects of mimosine. Infusions for 1 1/2 or 2 days at the daily rate of 80-120 mg/kg caused a cessation of wool growth by 1 1/2-2 days from the start of infusion, and all sheep were subsequently defleeced. It was estimated that, on average, fibre growth stopped for 10 1/2-13 days in four sheep after a 2-day infusion, and for 5 1/2 and 9 1/2 days in two sheep after an infusion for 1 1/2 days. There was considerable variation in the time taken for new fibres to recommence growth. During the period 3-5 weeks after infusion of mimosine, length growth rate was consistently greater than the pretreatment rate. Likewise, fibre diameter was greater in three out of the four sheep. As a result, the volume growth rate of fibres was greater post-treatment than it was pretreatment. Infusion for 3 weeks at the daily rate of 21-24 mg/kg did not stop wool growth. However, both length growth rate and fibre diameter were considerably depressed, and after 12 days' infusion, fibre diameter and volume growth rate were reduced to less than half the pretreatment values, and wool fibres were very weak. After the mimosine infusion stopped, fibre diameter increased to above pretreatment values and remained ther for the period of 2-3 weeks studied. The concurrent infusion of tyrosine, phenylalanine or cystine with mimosine failed to prevent any of the effects of mimosine on wool growth.
D000818:Animals; D003553:Cystine / Q000494:pharmacology; D003864:Depression, Chemical; D007263:Infusions, Parenteral; D008297:Male; D008898:Mimosine / Q000008:administration & dosage / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D010649:Phenylalanine / Q000494:pharmacology; D011728:Pyridones / Q000494:pharmacology*; D012756:Sheep; D014443:Tyrosine / Q000494:pharmacology; D014935:Wool / Q000254:growth & development*
D011728:Pyridones; D014443:Tyrosine; D010649:Phenylalanine; D003553:Cystine; D008898:Mimosine