title: Cytoplasmic and mitochondrial fractions of serum aspartate aminotransferase in the early phase of myocardial infarction.
abstract: The behavior of the mitochondrial and cytoplasmic fractions of aspartate aminotransferase (AAT) (E.C. 2.6.1.1) has been quantitatively evaluated in the serum of patients with acute myocardial infarction. For this purpose a new electrophoretic procedure on Cellogel strips with spectrophotometric evaluation has been used. An increase of the mitochondrial fraction of AAT has been observed in the very early phase of myocardial infarction (i.e., 6 hr after the onset of symptoms). The serum increase of the mitochondrial AAT precedes those of other enzymes, including creatine phosphokinase.
mesh_terms: D001219:Aspartate Aminotransferases / Q000097:blood*; D003402:Creatine Kinase / Q000097:blood; D003593:Cytoplasm / Q000201:enzymology; D006801:Humans; D007770:L-Lactate Dehydrogenase / Q000097:blood; D008931:Mitochondria, Muscle / Q000201:enzymology*; D009203:Myocardial Infarction / Q000201:enzymology*; D009206:Myocardium / Q000201:enzymology*
chemical_list: D007770:L-Lactate Dehydrogenase; D001219:Aspartate Aminotransferases; D003402:Creatine Kinase