[Effect of nicotine on the production of gastric acid (author's transl)].
15 test persons underwent intravenous injection of nicotine hydrogen tartrate. The acute effect on secretion rates and ionic composition of gastric acid was determined. Submaximal stimulation of gastric mucosa was reached with 50 mg/hr histalog applied intravenously. Nicotine hydrogen tartrate application of 0.012 to 0.020 mg/kg body weight in non smokers and of 0.022 to 0.034 mg/kg body weight in smokers caused the following changes: increase of concentration of hydrogen and chloride ions, decrease of ionic concentration of sodium and potassium in the gastric juice as well as slower secretion of sodium ions per time unit. A stomach stimulated intravenously by infusion of 2 mg/hr histalog per kg body weight is affected by intravenous injection of nicotine hydrogen tartrate  in amounts of 0.018 to 0.032 mg per kg body weight in non smokers and of 0.033 to 0.048 mg per kg body weight in smokers by a significant increase of concentration and secretion rates of hydrogen ions as well as a decrease of ionic potassium concentration in the gastric secretion. The increased gastric acid concentration caused by nicotine under maximal stimulation with histalog is discussed as promoting factor of ulceration and as retarding factor for the healing process.
D000328:Adult; D001625:Betazole / Q000494:pharmacology; D002712:Chlorides / Q000032:analysis; D005260:Female; D005745:Gastric Acidity Determination; D005750:Gastric Juice / Q000378:metabolism*; D005753:Gastric Mucosa / Q000187:drug effects*; D006801:Humans; D007275:Injections, Intravenous; D008297:Male; D008875:Middle Aged; D009538:Nicotine / Q000008:administration & dosage / Q000494:pharmacology*; D011188:Potassium / Q000032:analysis; D012907:Smoking; D012964:Sodium / Q000032:analysis; D013276:Stomach Ulcer / Q000209:etiology; D013644:Tartrates / Q000494:pharmacology; D013997:Time Factors; D014945:Wound Healing / Q000187:drug effects
D002712:Chlorides; D013644:Tartrates; D001625:Betazole; D009538:Nicotine; D012964:Sodium; D011188:Potassium
Wirkung von Nicotin auf die Sürebildung in menschlichen Magen