Biosynthesis and operating mechanism of estrogens in ovariectomized animals  under the effect of -SH groups.
This paper is part of a series aimed to investigate the mechanism of the action of Folcysteine, a substance that has the capacity to release in the body active -SH groups and has been proved to be effective in the control of menopausal troubles. As an experimental model the ovariectomized rat, rather similar, from the viewpoint of the hormonal balance, to the aged female, has been considered. Under these conditions, the effect, at the uterine and adrenalian level of the treatment with two different doses of estradiol with Folcysteine alone as well as associated with estradiol, has been investigated. Our results indicate that the active -SH groups released by Folcysteine intensify the effect of estrogens upon the uterine tissue and stimulate the estrogen biosynthesis at adrenalian level.
D000818:Animals; D001835:Body Weight / Q000187:drug effects; D002369:Castration; D003545:Cysteine / Q000031:analogs & derivatives / Q000494:pharmacology; D004338:Drug Combinations; D004958:Estradiol / Q000008:administration & dosage / Q000494:pharmacology; D004967:Estrogens / Q000096:biosynthesis* / Q000494:pharmacology; D005260:Female; D005492:Folic Acid / Q000031:analogs & derivatives / Q000494:pharmacology; D005954:Glucosephosphate Dehydrogenase / Q000378:metabolism; D009929:Organ Size / Q000187:drug effects; D011506:Proteins / Q000378:metabolism; D012313:RNA / Q000378:metabolism; D051381:Rats; D013438:Sulfhydryl Compounds / Q000494:pharmacology*; D014599:Uterus / Q000187:drug effects / Q000201:enzymology / Q000378:metabolism
D004338:Drug Combinations; D004967:Estrogens; D011506:Proteins; D013438:Sulfhydryl Compounds; D004958:Estradiol; D012313:RNA; C001642:folcysteine; D005492:Folic Acid; D005954:Glucosephosphate Dehydrogenase; D003545:Cysteine