title: Mechanism of protection against the delayed neurotoxic effects of organophosphorus esters.
abstract: Delayed neurotoxic effects arise as a result of two distinct biochemical events: 1) inhibiton of neurotoxic esterase, and 2) 'aging' of inhibited enzyme. Protective agents undergo reaction 1 but cannot undergo 2. Reaction 2 may interfere with a normal physiological control mechanism.
mesh_terms: D002800:Cholinesterase Inhibitors; D004950:Esterases / Q000037:antagonists & inhibitors; D008954:Models, Biological; D009474:Neurons / Q000187:drug effects* / Q000201:enzymology; D009943:Organophosphorus Compounds / Q000037:antagonists & inhibitors* / Q000633:toxicity
chemical_list: D002800:Cholinesterase Inhibitors; D009943:Organophosphorus Compounds; D004950:Esterases