[Participation of brain cholinergic mechanisms in the action of neuroleptics].
Tests conducted with mice demonstrated the neuroleptics droperidol, galoperidol and aethaperazine capable of subduing in mice greatly the agressive reaction provoked by an electric stimulation of pain and to distinctly raise at the same time the sensitivity of the M-cholinoreactive systems of the brain to the tremor-inducing effect of arecoline. Amizyl (benactyzil) and cyclodol, by abolishing this M-cholinopositive action of the neuroleptics, greatly reduce, at the same time, their antiagressive activity, Il may be presumed that in the antiagressive activity of neuroleptics the activation of the M-cholinergic plays a definite part in cerebral mechanisms produced by them.
D000374:Aggression / Q000187:drug effects; D000818:Animals; D000978:Antiparkinson Agents / Q000494:pharmacology; D001115:Arecoline / Q000494:pharmacology; D001535:Benactyzine / Q000494:pharmacology; D001921:Brain / Q000187:drug effects*; D002746:Chlorpromazine / Q000494:pharmacology; D004329:Droperidol / Q000494:pharmacology; D004347:Drug Interactions; D005239:Fear / Q000187:drug effects; D006220:Haloperidol / Q000494:pharmacology; D006801:Humans; D008297:Male; D051379:Mice; D010546:Perphenazine / Q000494:pharmacology; D011950:Receptors, Cholinergic / Q000187:drug effects*; D013565:Sympatholytics / Q000494:pharmacology; D014149:Tranquilizing Agents / Q000494:pharmacology*; D014202:Tremor / Q000139:chemically induced
D000978:Antiparkinson Agents; D011950:Receptors, Cholinergic; D013565:Sympatholytics; D014149:Tranquilizing Agents; D001115:Arecoline; D001535:Benactyzine; D010546:Perphenazine; D006220:Haloperidol; D004329:Droperidol; D002746:Chlorpromazine
Uchastie kholinergicheskikh mekhanizmov mozga v deĭstvii neĭroleptikov