[Duration of relaxation in the laryngeal and forearm muscles after succinyldicholine administration (author's transl)].
During laryngeal surgery with succinyldicholine relaxation it was noticed that the effects of the drug faded most quickly in the laryngeal muscles. To substantiate this observation an electromyographic study was made in 36 patients. 116 comparable action potentials were simultaneously recorded from the interarytenoid and flexor carpiulnaris muscles on a 4-track magnetic tape. An analysis of the recordings showed that action potentials in the larynx always re-appeared before those in the arm muscles. These results are different from those obtained by Spillmann who recorded action potentials in the tongue and arm. The time-lag between resumption of electrical activity in the larynx and the arm averaged 58 seconds. Possible causes of this difference are discussed. Succinyldicholine becomes effective 30 seconds after intravenous injection and its effects last 60-90 seconds. Recording the action potentials in the larynx during anaesthesia allows the accurate timing of further doses of muscle relaxants.
D000200:Action Potentials / Q000187:drug effects; D000293:Adolescent; D000328:Adult; D000368:Aged; D002648:Child; D002675:Child, Preschool; D005260:Female; D005542:Forearm; D006801:Humans; D007275:Injections, Intravenous; D007830:Larynx / Q000187:drug effects*; D008297:Male; D008875:Middle Aged; D009119:Muscle Contraction / Q000187:drug effects*; D013390:Succinylcholine / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000494:pharmacology; D013997:Time Factors
D013390:Succinylcholine
Relaxationsdauer--Unterschiede in Kehlkopf- und Unterarmmuskulatur des Menschen nach Depolarisationsblock