title: Lack of teratogenic dangers with halothane.
abstract: Chronic exposure of pregnant Sprague Dawley rats to a range of halothane concentrations from 50-3200 p.p.m. for 8 hours a day on days 8-12 of gestation failed to demonstrate significant teratogenicity in terms of foetal loss, growth, or skeletal abnormalities. Exposure to 1600 p.p.m. showed significant changes only in foetal weights, which were slightly decreased.
mesh_terms: D000014:Abnormalities, Drug-Induced; D000818:Animals; D005260:Female; D005333:Fetus / Q000187:drug effects*; D006221:Halothane / Q000009:adverse effects* / Q000378:metabolism; D006801:Humans; D009784:Occupational Diseases / Q000139:chemically induced; D009873:Operating Rooms; D011247:Pregnancy; D051381:Rats
chemical_list: D006221:Halothane