[Effect of etimizol, caffeine and theophylline on some carbohydrate metabolic indices of the rat brain and myocardium].
Intraperitoneal administration of aethimizol (25 mg/kg) was seen to bring down the quantity of glycogen, to raise the level of lactic and pyruvic acids and to increase the ration of lactate/pyruvate in the brain tissue of the rat. Caffeine and theophylline (25 mg/kg) caused similar, but not so pronounced changes in the content of the said substrates. All the 3 agents--aethimizol, caffeine and theophylline had some effect on the metabolic processes in the heart muscle.
D000818:Animals; D001921:Brain / Q000187:drug effects / Q000378:metabolism*; D002110:Caffeine / Q000494:pharmacology*; D050260:Carbohydrate Metabolism; D004305:Dose-Response Relationship, Drug; D005042:Etimizol / Q000494:pharmacology*; D006003:Glycogen / Q000378:metabolism; D006019:Glycolysis / Q000187:drug effects; D006321:Heart / Q000187:drug effects*; D007093:Imidazoles / Q000494:pharmacology*; D007773:Lactates / Q000378:metabolism; D008297:Male; D009206:Myocardium / Q000378:metabolism*; D011773:Pyruvates / Q000378:metabolism; D051381:Rats; D013806:Theophylline / Q000494:pharmacology*
D007093:Imidazoles; D007773:Lactates; D011773:Pyruvates; D002110:Caffeine; D006003:Glycogen; D013806:Theophylline; D005042:Etimizol
Vliianie étimizola, kofeina i teofillina na nekotorye pokazateli uglevodnogo obmena golovnogo mozga i serdechnoĭ myshtsy krys