[The comparative effects of actinomycin D, imuren and hydrocortisone on interferon and antibody formation in mice].
A single dose of actinomycin-D (2.5 mg/kg body wt) reduced the interferon formation 16-fold in comparison with control; as to the antibody production - it was completely abolished. Hydrocortiosone (100 mg/kg) also diminished the interferon production 16-fold, but had no effect on the production of antibodies against the virus. The effect of hydrocortisone on the antiviral immunity was similar to that of the antilymphocytic serum, whereas the action of actinomycin-D resembled the effect of the X-ray irradiation or imuran. The data obtained were consistent with the suggestion on the heterogeneity of cells, participating in the interferon production in the organism.
D000818:Animals; D000917:Antibody Formation / Q000187:drug effects*; D001379:Azathioprine / Q000494:pharmacology*; D003609:Dactinomycin / Q000494:pharmacology*; D006854:Hydrocortisone / Q000494:pharmacology*; D007166:Immunosuppressive Agents; D007372:Interferons / Q000096:biosynthesis*; D051379:Mice; D009522:Newcastle disease virus / Q000276:immunology
D007166:Immunosuppressive Agents; D003609:Dactinomycin; D007372:Interferons; D001379:Azathioprine; D006854:Hydrocortisone
Sravnitel'noe vliianie aktinomitsina D, imurana i gidrokortizona na obrazovanie interferona i antitel u mysheĭ