Topography of human urokinase activity in renal tissue.
Frozen sections of human kidneys were studied with a modified technique after TODD [22] )fibrinogen slides). Urokinase activity could be demonstrated in the juxtamedullary region (venae arcuatae, venae interlobulares, vasa recta) and in the epithelium of the calyces. Urokinase activity was specifically blocked by highly purified urokinase antibodies.
D000818:Animals; D000906:Antibodies / Q000302:isolation & purification; D000937:Antigen-Antibody Reactions; D001667:Binding, Competitive; D010450:Endopeptidases / Q000378:metabolism*; D004848:Epithelium / Q000201:enzymology; D005340:Fibrinogen / Q000378:metabolism; D005342:Fibrinolysis; D006801:Humans; D007606:Juxtaglomerular Apparatus / Q000201:enzymology; D007668:Kidney / Q000201:enzymology* / Q000276:immunology; D007670:Kidney Calices / Q000201:enzymology; D011817:Rabbits; D014568:Urokinase-Type Plasminogen Activator / Q000276:immunology / Q000378:metabolism*
D000906:Antibodies; D005340:Fibrinogen; D010450:Endopeptidases; D014568:Urokinase-Type Plasminogen Activator