General theory for rapidly establishing steady state drug concentrations using two consecutive constant rate intravenous infusions.
Steady state plasma drug concentrations can be achieved rapidly and safely by a drug input mode consisting of two consecutive constant rate intravenous infusions. A general method for calculating the relative rates of the two infusions is presented. The derivation is independent of the concepts of compartmental distribution and elimination of drugs within the body.
D007263:Infusions, Parenteral; D007700:Kinetics; D008433:Mathematics; D008722:Methods; D008954:Models, Biological; D004364:Pharmaceutical Preparations / Q000008:administration & dosage / Q000378:metabolism*; D013997:Time Factors
D004364:Pharmaceutical Preparations