title: Induction of pancreatic neoplasms by 2,2'-dioxopropyl-N-propylnitrosamine.
abstract: A high incidence of pancreatic duct adenomas and carcinomas were induced in Syrian golden hamsters as early as 13 weeks after chronic administration of 2,2'-dioxopropyl-n-propylnitrosamine (DOPN) at a 10 mg/kg dose. In contrast to another pancreatic carcinogen, 2,2'-dihydroxy-propyl-n-propyl-nitrosamine, DOPN induced no tumors of the upper respiratory tract or kidneys, and only a few neoplasms of the lungs and liver.
mesh_terms: D000230:Adenocarcinoma / Q000139:chemically induced; D000236:Adenoma / Q000139:chemically induced; D000818:Animals; D002277:Carcinoma / Q000139:chemically induced; D006224:Cricetinae; D005260:Female; D008175:Lung Neoplasms / Q000139:chemically induced; D008297:Male; D008647:Mesocricetus; D009374:Neoplasms, Experimental / Q000139:chemically induced; D009602:Nitrosamines / Q000633:toxicity*; D010183:Pancreatic Ducts; D010190:Pancreatic Neoplasms / Q000139:chemically induced*
chemical_list: D009602:Nitrosamines; C013622:nitrosobis(2-oxopropyl)amine