[Changes in the serum activity of lysosome enzymes in rats after application of the insecticide propoxur (Baygon)].
The effect of repeated peroral introduction (4 times) of 1/4 and 1/20 LD50 of monomethylcarbamate insecticide Propoxur (Baygon) on the activity of two lysosomal enzymes (beta-N-acetylglucosaminidase and alpha-mannosidase) is studied in the serum of white male rats with starting weight 300 g. Upon using the higher dose, a statistically significant rise (p less than 0.02) of the activity of either of the enzymes is established. The results obtained are interpreted as a sign of impaired permeability of the lysosomal and cell membrane.
D000118:Acetylglucosaminidase / Q000097:blood*; D000284:Administration, Oral; D000818:Animals; D004186:Disaccharidases / Q000097:blood*; D004305:Dose-Response Relationship, Drug; D004789:Enzyme Activation / Q000187:drug effects; D006596:Hexosaminidases / Q000097:blood*; D007928:Lethal Dose 50; D008247:Lysosomes / Q000201:enzymology*; D008297:Male; D008361:Mannosidases / Q000097:blood*; D001074:Propoxur / Q000633:toxicity*; D051381:Rats; D013997:Time Factors
D001074:Propoxur; D004186:Disaccharidases; D006596:Hexosaminidases; D008361:Mannosidases; D000118:Acetylglucosaminidase
Promeni v serumnata aktivnost na niakoi lizozomni enzimi u plukhove sled prilaganeto na insektitsida propoksur (baĭgon).