title: Paraquat poisoning in man.
abstract: In three cases of intoxication by Gramoxone¿, the concentration of paraquat dichloride in blood, dialysate, feces, and urine was determined spectrophotometrically after a clean-up of the biological material by means of ion exchange chromatography (with Dowex 50W-X12 or Zeo-Karb 225). Although good results were obtained after clean-up with Dowex 50W-X12, Zeo-Karb was preferred as ion exchange resin, especially when large sample volumes were needed for the determination. The reported findings indicate that: only 5 to 10% of an ingested dose of paraquat dichloride is absorbed in man, Fullers' earth is very useful, and that primary, e.g. immediate, hemodialysis is necessary.
mesh_terms: D000328:Adult; D000538:Aluminum Silicates / Q000008:administration & dosage; D005243:Feces / Q000032:analysis; D005260:Female; D006801:Humans; D007475:Ion Exchange Resins; D008297:Male; D008875:Middle Aged; D010269:Paraquat / Q000032:analysis / Q000378:metabolism / Q000506:poisoning*; D011041:Poisoning / Q000628:therapy; D006435:Renal Dialysis
chemical_list: D000538:Aluminum Silicates; D007475:Ion Exchange Resins; D010269:Paraquat