Schizophrenia susceptibility and HL-A antigen.
The phenotype frequencies of HL-A specificities have been investigated in 47 chronic schizophrenics subdivided in an older and a younger group. The frequency of HL-A 9 was significantly increased in the psychotics as compared to a reference group of 1,263 healthy blood donors, pregnant women and potential kidney donors. Deviations in frequency were also found concerning W 19 and HL-A 5. As HL-A 9 was mainly found in the older group of schizophrenics, it is suggested that HL-A 9 might be associated to some form of schizophrenia with a chronic course.
D000328:Adult; D000367:Age Factors; D000368:Aged; D005260:Female; D006680:HLA Antigens / Q000032:analysis*; D006649:Histocompatibility Antigens / Q000032:analysis*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011569:Psychiatric Status Rating Scales; D012559:Schizophrenia / Q000175:diagnosis / Q000276:immunology*
D006680:HLA Antigens; D006649:Histocompatibility Antigens