[Specificity and mechanism of serotonin stimulation of adenylate deaminase activity].
Adenylate deaminating activity was stimulated in the liver mitochondria of rats in vivo not only by serotonin or synthetic indolylalkylamines, but also by phenyl- and imidazolalkyamines. Actinomycin D and cycloheximide protein biosynthesis inhibitors prevented stimulation of adenylate deaminating activity. Theophylline, phosphodiesterase inhibitor, produced a similar effect only when the extent of stimulation of adenylate deaminating activity was comparatively high.
D000659:AMP Deaminase / Q000037:antagonists & inhibitors / Q000378:metabolism*; D000588:Amines / Q000494:pharmacology; D000818:Animals; D003513:Cycloheximide / Q000494:pharmacology; D003609:Dactinomycin / Q000494:pharmacology; D004347:Drug Interactions; D004789:Enzyme Activation / Q000187:drug effects; D004794:Enzyme Repression / Q000187:drug effects; D051379:Mice; D008808:Mice, Inbred CBA; D008930:Mitochondria, Liver / Q000201:enzymology; D009709:Nucleotide Deaminases / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains; D012701:Serotonin / Q000494:pharmacology*; D013268:Stimulation, Chemical; D013806:Theophylline / Q000494:pharmacology
D000588:Amines; D003609:Dactinomycin; D012701:Serotonin; D003513:Cycloheximide; D013806:Theophylline; D009709:Nucleotide Deaminases; D000659:AMP Deaminase
O spetsifichnosti i mekhanizme stimuliatsii serotoninom adenilatdezaminaznoĭ aktivnosti