Effects of delta-9-tetrahydrocannabinol on social behaviour in the laboratory mouse and rat.
The behavioural effects of delta-9-tetrahydrocannabinol in mice and rats have been studied by an ethological analysis of encounters between animals injected with the drug and partners injected with the solvent (Tween-saline). In both species, Immobility was increased and Non-Social Activity reduced after injections of 5 mg/kg of delta-9-tetrahydrocannabinol. Flight was increased in treated mice but not in treated rats. Aggression was not significantly altered in either species. Thus, in the mouse, the qualitative behavioural effects of delta-9-tetrahydrocannabinol were similar to those previously reported for crude cannabis resin. Comparison of the dose-response data indicated that some other constituents of cannabis may reduce the Flight reaction from delta-9-tetrahydrocannabinol although not interfering with Immobility.
D000374:Aggression / Q000187:drug effects; D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects*; D002188:Cannabis / Q000494:pharmacology*; D013759:Dronabinol / Q000494:pharmacology*; D004924:Escape Reaction / Q000187:drug effects; D006801:Humans; D008297:Male; D051379:Mice; D051381:Rats; D012726:Sexual Behavior, Animal / Q000187:drug effects; D012919:Social Behavior / Q000187:drug effects*
D013759:Dronabinol