title: Syphilitic hepatitis: clinical, immunological and morphological aspects.
abstract: In 17 out of 176 cases of early syphilis (seropositive syphillis I; syphilis II) liver function tests yielded a positive result. In these patients a significant increase in the serum IgG, IgM and coeruloplasmin levels and a decrease in t4e transferrin level was found. The concentrations of alpha-2-macroglobulin and of beta-1-C-globulin were practically uneffected. Liver biopsy revealed hepatitis of variable severity in 13 patients with focal necroses or a proliferative process effecting the walls of the central veins, the arterioles and the branches of the portal vein. In 7 cases the presence of Treponema in the liver was demonstrated.
mesh_terms: D000328:Adult; D000368:Aged; D005260:Female; D006505:Hepatitis / Q000097:blood / Q000209:etiology* / Q000473:pathology; D006801:Humans; D007136:Immunoglobulins / Q000378:metabolism; D008099:Liver / Q000473:pathology; D008297:Male; D008875:Middle Aged; D013587:Syphilis / Q000097:blood / Q000150:complications* / Q000473:pathology
chemical_list: D007136:Immunoglobulins