[Immunodepressive effect of phentyrin].
A study was made of the immunodepressive activity of phentirin (dichlohydrate o/p-di (2-cholorethyl) aminophenyl/D,L-tyrosine). The preparation was administered to mice in a dose of 50 mg/kg, per os. Experimental results showed phentirin to produce a marked immunodepressive action on the transplantation immunity and the production of plaque- and rosette-forming cells. Immunodepressive action of phentirin was more pronounced in comparison with azaprine under the same experimental conditions.
D000818:Animals; D000921:Antibody-Producing Cells / Q000187:drug effects; D001379:Azathioprine / Q000494:pharmacology; D005260:Female; D007109:Immunity / Q000187:drug effects*; D007166:Immunosuppressive Agents; D051379:Mice; D009588:Nitrogen Mustard Compounds / Q000494:pharmacology*
D007166:Immunosuppressive Agents; D009588:Nitrogen Mustard Compounds; D001379:Azathioprine
Immunodepressivnye svoĭstva fentirina