Studies on the intrathecal pharmacotherapy. Part I: CDP-choline.
A study was made of the intrathecal infusion as a route of administration of drugs for the CNS, by giving due consideration to the presence of blood-brain and CSF-brain barriers. CDP-choline was used as the brain activator, and the effect of the drug intrathecally infused was investigated both clinically and by experiments on animals. Seven patients with a disturbance of consciousness due to primary brain lesion received a total of 19 intrathecal infusions of CDP-choline, and were examined for the effect of the treatment neurologically and electroencephalographically. Wistar rats were infused either intravascularly or intracisternally with 14C-CDP-choline, and the distribution in the body was investigated by whole body autoradiography.
D000293:Adolescent; D000328:Adult; D000368:Aged; D000818:Animals; D001345:Autoradiography; D001921:Brain / Q000378:metabolism; D001926:Brain Death; D001930:Brain Injuries / Q000188:drug therapy*; D002794:Choline / Q000031:analogs & derivatives*; D003243:Consciousness / Q000187:drug effects; D003566:Cytidine Diphosphate Choline / Q000008:administration & dosage* / Q000378:metabolism; D004569:Electroencephalography; D005260:Female; D006801:Humans; D007278:Injections, Spinal; D008297:Male; D008875:Middle Aged; D051381:Rats; D013116:Spinal Cord / Q000378:metabolism
D003566:Cytidine Diphosphate Choline; D002794:Choline