title: Dermatopharmacology of salicylic acid. II. Epidermal antihyperplastic effect of salicylic acid in animals.
abstract: The influence of salicylic acid on pathological epithelial proliferation has been evaluated by means of the peidermal hyperplasia inhibition test in the guinea pig. 3% w/w salicylic acid dissolved in ethanol reduced surface epithelial hyperplasia by 15%, i.e. exhibited activity comparable to that of hydrocortisone 0.1% w/w. 1% w/w salicylic acid dissolved in a dimethylacetamide-acetone-ethanol mixture exerted an even greater degree of antihyperplastic activity on the surface epithelium (-18%) and also a marked inhibitory effect on deep epithelial proliferation (-10%).
mesh_terms: D000081:Acetamides / Q000494:pharmacology; D000096:Acetone / Q000494:pharmacology; D000287:Administration, Topical; D000818:Animals; D001835:Body Weight / Q000187:drug effects; D002455:Cell Division / Q000187:drug effects; D004353:Drug Evaluation, Preclinical; D004357:Drug Synergism; D004847:Epithelial Cells; D004848:Epithelium / Q000187:drug effects; D000431:Ethanol / Q000494:pharmacology; D006168:Guinea Pigs; D006838:Hydrocarbons / Q000494:pharmacology; D006965:Hyperplasia; D008297:Male; D012459:Salicylates / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D012867:Skin / Q000187:drug effects* / Q000473:pathology; D012871:Skin Diseases / Q000188:drug therapy; D012997:Solvents / Q000494:pharmacology
chemical_list: D000081:Acetamides; D006838:Hydrocarbons; D012459:Salicylates; D012997:Solvents; D000096:Acetone; D000431:Ethanol