[Clinical evaluation of delayed and immediate hypersensitivity to antigens of the connective tissue, myocardium and hemolytic Streptococcus in patients with rheumatic fever].
The results of a study of some humoral and cellular immunological reactions to antigens of the myocardium and connective tissues of cardiac vlaves, as well as to those of the haemolytic Streptococcus in rheumatic patients are presented. Antibodies to 4 antigens were deter mined, to cellular form of immunity was examined by the method of leucocytes migration inhibition. The studies have indicated that in rheumatism, hupersensitivity of a delayed and non-delayed type manifests itself. The activity of the inflammatory process, its severity, the nature and severity of carditis are to a great extent reflected by the connective tissue antibodies to the basic substance, especially to the structural glycoprotein of the valves. In cases of the most unfavourable clinical forms of the rheumatic process the signs of streptococcal sensitization and autoallergy to both musclular and connective tissue cardiac structures are especially vivid.
D000293:Adolescent; D000328:Adult; D000818:Animals; D000937:Antigen-Antibody Reactions; D000941:Antigens; D000942:Antigens, Bacterial; D001323:Autoantibodies / Q000302:isolation & purification*; D002464:Cell Migration Inhibition; D003238:Connective Tissue / Q000276:immunology; D005260:Female; D006023:Glycoproteins / Q000276:immunology; D006351:Heart Valves / Q000276:immunology; D006801:Humans; D006968:Hypersensitivity, Delayed / Q000175:diagnosis*; D006969:Hypersensitivity, Immediate / Q000175:diagnosis*; D008297:Male; D009206:Myocardium / Q000276:immunology; D012213:Rheumatic Fever / Q000276:immunology*; D013291:Streptococcus / Q000276:immunology; D014020:Tissue Extracts / Q000276:immunology
D000941:Antigens; D000942:Antigens, Bacterial; D001323:Autoantibodies; D006023:Glycoproteins; D014020:Tissue Extracts
Klinicheskaia otsenka immunologicheskikh reaktsiĭ zamedlennogo i nemedlennogo tipa k antigenam soedinitel'noĭ tkani, miokarda i gemoliticheskogo Streptokokka u bol'nykh revmatizmom