[Effect of dibazol, euphylline, No-Spa and galidor on thrombocyte osmotic resistance and blood clot retraction].
The osmotic resistance of thrombocytes and the blood clot retraction are shown to diminish in the presence of nospanum and holidor in the plasma and blood. A double logarithmic relationship between the values characterizing the action on the osmotic resistance of thrombocytes and the blood clot refraction, on the one hand, and concentrations of some of the study substances, on the other, was revealed. With parenteral introduction the fall of the osmotic resistance of thrombocytes and an increase in the amount of the retracted serum were noted to occur with a protracted subcutaneous injection of dibasol (5 mg/kg), whereas euphylline (24 mg/kg) caused only a smaller degree of retraction.
D000628:Aminophylline / Q000494:pharmacology*; D000818:Animals; D000959:Antihypertensive Agents / Q000494:pharmacology*; D001537:Bencyclane; D001562:Benzimidazoles / Q000494:pharmacology*; D001593:Benzyl Compounds / Q000494:pharmacology; D001702:Biopharmaceutics; D001792:Blood Platelets / Q000187:drug effects*; D003018:Clot Retraction; D004305:Dose-Response Relationship, Drug; D004987:Ethers; D005260:Female; D066298:In Vitro Techniques; D007546:Isoquinolines / Q000494:pharmacology; D008297:Male; D008433:Mathematics; D009996:Osmotic Fragility / Q000187:drug effects*; D010208:Papaverine / Q000031:analogs & derivatives*; D051381:Rats; D013997:Time Factors; D014665:Vasodilator Agents / Q000494:pharmacology*
D000959:Antihypertensive Agents; D001562:Benzimidazoles; D001593:Benzyl Compounds; D004987:Ethers; D007546:Isoquinolines; D014665:Vasodilator Agents; C004453:bendazole; D000628:Aminophylline; D001537:Bencyclane; C005317:drotaverin; D010208:Papaverine
Vliianie dibazola, éufillina, no-shpy i galidora na osmoticheskuiu rezistentnost' trombotsitov i retraktsiiu krovianogo sgustka