title: Formation of indoleacetic acid by intestinal anaerobes.
abstract: Indoleacetic acid was produced from tryptophan by only three of 23 intestinal anaerobes studied. Evidence is presented to show that the formation of indoleacetic acid proceeds through the intermediate, indolepyruvic acid, via transamination with alpha-ketoglutarate rather than by tryptamine pathway.
mesh_terms: D000693:Anaerobiosis; D000818:Animals; D001419:Bacteria / Q000378:metabolism*; D001441:Bacteroides fragilis / Q000378:metabolism; D002954:Citrobacter / Q000378:metabolism; D005243:Feces / Q000382:microbiology; D007210:Indoleacetic Acids / Q000378:metabolism*; D007422:Intestines / Q000382:microbiology*; D007490:Iproniazid / Q000494:pharmacology; D007656:Ketoglutaric Acids / Q000378:metabolism; D011773:Pyruvates / Q000378:metabolism; D051381:Rats; D014363:Tryptamines / Q000378:metabolism; D014364:Tryptophan / Q000378:metabolism
chemical_list: D007210:Indoleacetic Acids; D007656:Ketoglutaric Acids; D011773:Pyruvates; D014363:Tryptamines; D014364:Tryptophan; D007490:Iproniazid