Angiotensin II stimulation of 5'-adenylic acid deaminase.
Angiotensin II has been found to stimulate 5'-adenylic acid deaminase from rabbit skeletal muscle. Stimulation was discernible around 10(-9) M and peak stimulation of about threefold was seen at 10(-7) M, concentrations approximating those required for stimulation of vascular smooth muscle or adrenal glomerulosa cells. Higher concentrations produced less stimulation. Adenosine triphosphate stimulated to the same degree, but a concentration of 10(-5) M was required for maximum stimulation, while maximum stimulation with sodium or potassium required 0.5 M and 0.75 M, respectively. Although the physiologic significance of these observations has not been established, these data suggest an intracellular role for angiotensin II.
D000659:AMP Deaminase / Q000378:metabolism*; D000255:Adenosine Triphosphate / Q000494:pharmacology; D000804:Angiotensin II / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D004789:Enzyme Activation; D009132:Muscles / Q000201:enzymology; D009709:Nucleotide Deaminases / Q000378:metabolism*; D011189:Potassium Chloride / Q000494:pharmacology; D012965:Sodium Chloride / Q000494:pharmacology
D000804:Angiotensin II; D012965:Sodium Chloride; D011189:Potassium Chloride; D000255:Adenosine Triphosphate; D009709:Nucleotide Deaminases; D000659:AMP Deaminase