[Ciguatera: neurophysiological demonstration of toxicity of several ciquatoxic fractions].
Raw extracts from one Polynesian, frequently ciguatera-inducing fish were submitted to fractional distillation by means of a chromatographic process using a silicic acid column. Three out of the seven fractions split this way exhibited either anticholinesterasic properties, or directly toxic properties at the muscle-cell level: fraction 5, which is not antagonized by atropine, presumably accounts for this direct action, as it competes with calcium at membrane sites. Fraction 6 appears to be more specially responsible for the anticholinesterasic action. It revealed a quaternary ammonium ion in its 6-2 sub-fraction. Fraction 7 shows the same properties as fraction 6, but on a smaller scale.
D000200:Action Potentials / Q000187:drug effects; D000818:Animals; D001285:Atropine / Q000494:pharmacology; D001667:Binding, Competitive; D002118:Calcium / Q000494:pharmacology; D002463:Cell Membrane Permeability / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D004558:Electric Stimulation; D005400:Fishes, Poisonous; D006801:Humans; D066298:In Vitro Techniques; D007275:Injections, Intravenous; D008297:Male; D008387:Marine Toxins / Q000302:isolation & purification / Q000494:pharmacology*; D008564:Membrane Potentials / Q000187:drug effects; D051379:Mice; D009119:Muscle Contraction / Q000187:drug effects*; D009121:Muscle Denervation; D009132:Muscles / Q000187:drug effects*; D009469:Neuromuscular Junction / Q000187:drug effects*; D011114:Polynesia; D051381:Rats
D008387:Marine Toxins; D001285:Atropine; D002118:Calcium
Ciguatera: mise en évidence neurophysiologique de la toxicité de diverses fractions ciguatoxiques