title: [Methicillin levels in the human serum, pericardial effusion and myocardium].
abstract: The antibiotic level in the serum, pericardial fluid and myocardium of 11 patients prepared for heart surgery was tested by means of the agar-diffusion method after the intramuscular administration of 1 g of methicillin. The mean level after 1 to 3 hours was 14.7 mcg/ml in serum, 1.7 mcg/ml in the pericardial fluid and 8.2 mcg/g in the myocardium. In the case of drug sensitivity, the myocardial methicillin concentration is sufficient for the treatment of Gram-positive infections. If the infection is localized in the pericardium, higher doses, local applications, drug combination or complex therapy might be called for.
mesh_terms: D000293:Adolescent; D000328:Adult; D001424:Bacterial Infections / Q000188:drug therapy; D002648:Child; D005260:Female; D006331:Heart Diseases / Q000601:surgery; D006801:Humans; D008297:Male; D008712:Methicillin / Q000097:blood / Q000378:metabolism* / Q000627:therapeutic use; D009206:Myocardium / Q000378:metabolism*; D010490:Pericardial Effusion / Q000378:metabolism*; D011300:Preoperative Care
chemical_list: D008712:Methicillin
vernacular_title: Untersuchung der Methicillinkonzentration im Serum, in der perikardialen Flüssigkeit und im Myokard beim Menschen