Pharmacokinetics of chlormethiazole in humans.
The pharmacokinetics of chlormethiazole have been studied in six healthy volunteers following an intravenous infusion of the drug. The log. plasma concentration-time curve of chlormethiazole after cessation of the infusion was found to be curvilinear and was fitted therefore, by a bi-exponential equation computed by non-linear least squares regression analysis. Half-lives for the initial alpha-phase (0.54+/-0.05 h) and the terminal beta-phase (4.05+/-0.60 h) were calculated together with other pharmacokinetic parameters of the two compartment open model. An explanation for the discrepancy between the presently reported plasma half-lives and those appearing in the literature has been presented. The pharmacokinetic treatment of the plasma concentration-time data obtained following intravenous infusion also enabled the prediction that the maximal systemic availability of an orally administered dose of chlormethiazole would be of the order of 15%.
D000284:Administration, Oral; D000328:Adult; D001682:Biological Availability; D002719:Chlormethiazole / Q000008:administration & dosage / Q000378:metabolism*; D002849:Chromatography, Gas; D005260:Female; D006207:Half-Life; D006801:Humans; D007263:Infusions, Parenteral; D007700:Kinetics; D008297:Male; D008433:Mathematics; D008954:Models, Biological
D002719:Chlormethiazole