[Preclinical research--toxicology].
The different steps of the toxicological testing of new drugs are shortly described. Furthermore it is discussed that only 60-70% of the drug induced adverse reactions in man can be predicted by the experimental methods being available at present. Special problems exist in evaluating the results of reproductive-toxicological, carcinogenicity and mutagenicity tests. These problems are illustrated by some experimental and clinical examples.
D000818:Animals; D002273:Carcinogens / Q000494:pharmacology; D002869:Chromosome Aberrations; D002875:Chromosomes / Q000187:drug effects; D004285:Dogs; D004353:Drug Evaluation, Preclinical; D004622:Embryo, Mammalian / Q000187:drug effects; D005260:Female; D008297:Male; D051379:Mice; D009153:Mutagens / Q000494:pharmacology; D011247:Pregnancy; D051381:Rats; D012098:Reproduction / Q000187:drug effects; D012106:Research; D013723:Teratogens / Q000494:pharmacology; D013997:Time Factors; D014116:Toxicology
D002273:Carcinogens; D009153:Mutagens; D013723:Teratogens
Präklinische Untersuchungen--Toxikologie