[Sialoadenosis produced by drug-treatment of hypertonicity. I. Experimental studies on the effects of guanethidine (Ismelin) on the parotid glands of the rat (author's transl)].
48 rats were treated with the antihypertensive drug, guanethidine; its effects on the parotid glands (alpha-amylase content, protein concentration, and isamylase distribution patterns) were investigated. The treatment significantly increased the amylase activity in the gland extracts as well as the concentration of isoamylases and their specific enzyme activities. Moreover, we found a redistribution of activity between the 4 isoamylases of the parotid glands. The observed changes are the manifestations of a proteodyschylia concomitant with a peripheral neurogenic sialoadenosis. The described alterations are fully reversible within two weeks after discontinuation of the guanethidine application.
D000818:Animals; D005260:Female; D006145:Guanethidine / Q000009:adverse effects* / Q000494:pharmacology / Q000627:therapeutic use; D006973:Hypertension / Q000188:drug therapy*; D007517:Isoamylase / Q000378:metabolism; D010306:Parotid Gland / Q000187:drug effects* / Q000201:enzymology; D051381:Rats; D012466:Salivary Gland Diseases / Q000139:chemically induced*; D012793:Sialadenitis / Q000139:chemically induced*
D007517:Isoamylase; D006145:Guanethidine
Die Sialoadenose des therapierten Hypertonikers I. Experimentelle Untersuchungen über die Auswirkungen von Guanethidin (Ismelin) auf die Ohrspeicheldrüsen der Ratte