Mycotoxin-producing fungi from house associated with leukemia.
Fungi were isolated from a house associated with four leukemic patients from three families because of the possibility that mycotoxin-producing strains might be present. Extracts of several of the isolated fungal species produced toxic effects in one or more species of animals. Aflatoxin-producing Aspergillus parasiticus was isolated from non-leukemia-associated houses with the exception of Trichoderma, Verticillium, and Monotospora. We believe that certain mycotoxins may be related to pathogenesis of leukemia, possibly as an expression of their immunosuppressive effects.
D000328:Adult; D000818:Animals; D001230:Aspergillus / Q000302:isolation & purification; D002675:Child, Preschool; D006224:Cricetinae; D004372:Ducks; D005260:Female; D005658:Fungi / Q000302:isolation & purification*; D006798:Housing; D006801:Humans; D007938:Leukemia / Q000209:etiology / Q000235:genetics*; D008297:Male; D009183:Mycotoxins; D014242:Trichoderma / Q000302:isolation & purification
D009183:Mycotoxins