A study of the growth inhibition of Lactobacillus casei by N-alkyl homologs of N-nitro-N-nitrosoguanidine.
N-methyl-(MNNG), N-ethyl-(ENNG), and N-propyl-(PNNG) derivatives of N'-nitro-N-nitrosoguanidine inhibited the growth of Lactobacillus casei in the order of potency, MNNG greater than ENNG greater than PNNG. L-Cysteine, gluathione, and dithioerythritol reversed the inhibition on a molar basis. The -SH compounds accelerated the loss of the N-nitroso group in vitro, yielding non-inhibitory N-alkyl nitroguanidines. The significance of the loss of the nitroso group and the size of the N-alkyl group is discussed.
D002455:Cell Division / Q000187:drug effects; D003545:Cysteine / Q000494:pharmacology; D004226:Dithioerythritol / Q000494:pharmacology; D005978:Glutathione / Q000494:pharmacology; D008769:Methylnitronitrosoguanidine / Q000494:pharmacology; D009574:Nitro Compounds / Q000494:pharmacology*; D009604:Nitrosoguanidines / Q000494:pharmacology*; D013329:Structure-Activity Relationship
D009574:Nitro Compounds; D009604:Nitrosoguanidines; D008769:Methylnitronitrosoguanidine; D004226:Dithioerythritol; D005978:Glutathione; D003545:Cysteine