Alpha-chymotrypsin glaucoma.
The postoperative course of 141 eyes in 115 patients undergoing uncomplicated intracapsular cataract extraction was reviewed. Alpha-chymotrypsin as used in our institution did not increase the percentage of eyes developing significant postoperative ocular hypertension. Smaller amounts of enzyme and a shorter waiting period than have heretofore been advocated are adequate for clinically effective zonulysis and appear to be protective against "enzyme glaucoma." Indeed, we found that among non-diabetics, those receiving enzyme experienced a lower incidence of postoperative ocular hypertension than did those not receiving enzyme. The one factor in our series related to an increased percentage of postoperative hypertensive responses was diabetes mellitus.
D000328:Adult; D000367:Age Factors; D000368:Aged; D002387:Cataract Extraction / Q000009:adverse effects*; D002918:Chymotrypsin / Q000009:adverse effects*; D048909:Diabetes Complications; D005260:Female; D005901:Glaucoma / Q000139:chemically induced* / Q000175:diagnosis; D006801:Humans; D007429:Intraocular Pressure / Q000187:drug effects; D008297:Male; D008875:Middle Aged
D002918:Chymotrypsin