Autoperfused multi-organ preparations. II. Microcirculation in the autoperfused organs.
The microcirculation of 46 autoperfused heart-lung-liver-duodenum-pancreas-kidney preparations has been studied and the acid-base conditions were determined. The stability of the autoperfused organ preparation was not ensured by the "multi-organ" arrangement, moreover the combination had a detrimental effect, with reduced tissue perfusion leading to hypoxia and acidosis. This general vasomotor breakdown represented a therapeutic drug resistance, so that the organ preparation failed to solve the problem of temporary organ preservation.
D000818:Animals; D004285:Dogs; D004386:Duodenum / Q000502:physiology; D006321:Heart / Q000502:physiology; D007668:Kidney / Q000502:physiology; D008099:Liver / Q000502:physiology; D008833:Microcirculation; D009926:Organ Preservation; D010179:Pancreas / Q000502:physiology; D010477:Perfusion; D014021:Tissue Preservation