Adrenaline-forming enzyme in brainstem: elevation in genetic and experimental hypertension.
The adrenaline-forming enzyme (phenylethanolamine N-methyltransferase) was elevated in the A1 and A2 regions of the brainstem of 4-week-old spontaneously (genetic) hypertensive rats and in the A1 region of adult experimentally (deoxycorticosterone acetate and sodium chloride) hypertensive rats. The administration of a phenylethanolamine N-methyltransferase inhibitor to experimentally hypertensive animals caused a reduction of the elevated blood pressure to normal values. These results implicate adrenaline-containing neurons in the brainstem in the development of hypertension.
D001794:Blood Pressure / Q000187:drug effects; D001933:Brain Stem / Q000201:enzymology*; D003900:Desoxycorticosterone / Q000494:pharmacology; D006973:Hypertension / Q000139:chemically induced / Q000201:enzymology* / Q000235:genetics / Q000503:physiopathology; D010625:Phenylethanolamine N-Methyltransferase / Q000037:antagonists & inhibitors / Q000378:metabolism*; D011725:Pyridines / Q000494:pharmacology; D013876:Thiophenes / Q000494:pharmacology
D011725:Pyridines; D013876:Thiophenes; D003900:Desoxycorticosterone; D010625:Phenylethanolamine N-Methyltransferase