Ovulation induced by the intraventricular infusion of norepinephrine in rats made anovulatory by neonatal administration of various doses of testosterone.
Gradually increasing doses of neonatal TP decrease the rate of ovulation induced by intraventricular infusion of 100 mug of NE. This finding suggests that the reduced functional capacity of the LH-RH-producing neurons in androgen-sterilized rats may account for the difference between the ovulatory action of NE in anterior hypothalamus-lesioned and androgen-sterilized rat.
D000818:Animals; D000831:Animals, Newborn; D001812:Blood-Brain Barrier; D004336:Drug Antagonism; D005260:Female; D007031:Hypothalamus / Q000293:injuries; D007276:Injections, Intraventricular; D009638:Norepinephrine / Q000008:administration & dosage / Q000494:pharmacology*; D010060:Ovulation / Q000187:drug effects*; D051381:Rats; D013739:Testosterone / Q000494:pharmacology*
D013739:Testosterone; D009638:Norepinephrine