[Refinement of mensurational methods in human pharmacology].
In healthy persons the changes in heart rate and myocardial contractility induced by oxprenolol and phentolamine are more marked in the erect position and during physical exertion then in recumbency. Similarly, a dose-effect relation with regarded to the negatively inotropic activity of oxprenolol is more readily detectable in the upright position.
D004305:Dose-Response Relationship, Drug; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D009200:Myocardial Contraction / Q000187:drug effects; D010096:Oxprenolol / Q000494:pharmacology; D010600:Pharmacology; D010646:Phentolamine / Q000494:pharmacology; D005082:Physical Exertion; D010919:Placebos; D011187:Posture; D012107:Research Design; D013997:Time Factors
D010919:Placebos; D010096:Oxprenolol; D010646:Phentolamine
Beispiele einer Verfeinerung der Messmethodik in der Humanpharmakologie