[Influence of efferent biliary ducts on the composition of bile acids. Studies on subjects with cholesterol gall stones and a stone-free control group].
Cadaveric livers and their gall bladders were used in order to determine the bile acids following separation by thin layer chromatography; spectrophotofluorimetry was employed. In the hepatic tissue of the lithiasis patients the bile acid concentrations and the ratio of the trihydroxycholanic acid (cholic acid) to the dihydroxycholanic acids (desoxycholic acid and chenodesoxycholic acid) are lower than in the control group. In the B-bile only cholic acid and the quotient cholic acid to chenodesoxycholic acid reveal any significant differences. Also, there exists an established positive correlation between the bile acid concentration in the hepatic tissue and in the B-bile of the alcoholic test persons but not in the cholelithiasis patients. From this we may infer that the concomitant inflammation of the gall bladder has an influence on the composition of the bile acids.
D001344:Autopsy; D001647:Bile Acids and Salts / Q000032:analysis* / Q000378:metabolism; D001652:Bile Ducts / Q000378:metabolism*; D002102:Cadaver; D002769:Cholelithiasis / Q000378:metabolism*; D002784:Cholesterol / Q000378:metabolism*; D006801:Humans
D001647:Bile Acids and Salts; D002784:Cholesterol
Der Einfluss der abführenden Gallenwege auf die Zusammensetzung der Gallensäuren. Untersuchungen bei Cholesterinsteinträgern und einer steinfreien Vergleichsgruppe