Facilitated shock-induced aggression following antidepressive medication in the rat.
Rats were tested for changes in shock-induced fighting following treatment with antidepressants of both the dibenzazepine and monoamine oxidase inhibitor classes of drug. Rats were retested for shock-induced fighting 3, 4, and 5 days after initial injections of imipramine (10 mg/kg IP bid), or saline. All three dibenzazepine groups showed increased levels of shock-induced fighting (p less than 0-01). In addition, rats were retested for shock-induced fighting 6, 30. 54, and 78 hours following the initiation of treatment with daily injections of saline, or the monoamine oxidase inhibitors: nialamide (100 mg/kg/day), iproniazid (150 mg/kg/day), and pargyline (20 mg/kg/day). All three monoamine oxidase inhibitor groups showed increased levels of shock-induced fighting after 30 hr (p less than 0.001). There was no difference in the jump threshold of rats treated with pargyline or saline.
D000374:Aggression / Q000187:drug effects*; D000818:Animals; D000928:Antidepressive Agents / Q000494:pharmacology*; D003984:Dibenzazepines / Q000494:pharmacology; D004597:Electroshock; D006801:Humans; D008297:Male; D008996:Monoamine Oxidase Inhibitors / Q000494:pharmacology; D051381:Rats; D013268:Stimulation, Chemical; D013997:Time Factors
D000928:Antidepressive Agents; D003984:Dibenzazepines; D008996:Monoamine Oxidase Inhibitors