Myeloid hyperplasia in growing rats after chronic treatment with delta 9-THC at behavioral doses.
Delta 9-THC at the dose of 1 mg/kg/die was administered subcutaneously in growing rats, from the second to the 30th day of life. A statistically significant myeloid hyperplasia was demonstrated, which persisted up to 4 months after the end of the treatment, together with significant blood granulocytosis.
D000818:Animals; D000831:Animals, Newborn; D001853:Bone Marrow / Q000254:growth & development; D001855:Bone Marrow Diseases / Q000139:chemically induced*; D002188:Cannabis / Q000494:pharmacology*; D013759:Dronabinol / Q000494:pharmacology*; D006098:Granulocytes; D006410:Hematopoiesis / Q000187:drug effects*; D006965:Hyperplasia; D008297:Male; D051381:Rats
D013759:Dronabinol