Inhibition of measles virus replication and enhancement of cellular DNA synthesis in vero cells by ribavirin, an antiviral and antineoplastic drug.
Excellent in vitro inhibition of measles virus infectivity by ribavirin was detectable by a tube method allowing prolonged maintenance which makes possible the evaluation of efficiency at daily intervals. Optimal efficiency occurred on day 5 to 7, depending on the drug dose. Although syntheses of cellular RNA and protein were inhibited by low drug dosage, the de novo DNA synthesis was enhanced. Peak 4-fold enhancement resulted with 320 mug/ml after 2 days treatment.
D002460:Cell Line; D004279:DNA, Viral / Q000096:biosynthesis*; D004305:Dose-Response Relationship, Drug; D008459:Measles virus / Q000378:metabolism*; D012367:RNA, Viral / Q000096:biosynthesis; D012254:Ribavirin / Q000494:pharmacology*; D012263:Ribonucleosides / Q000494:pharmacology*; D014764:Viral Proteins / Q000096:biosynthesis; D014779:Virus Replication / Q000187:drug effects*
D004279:DNA, Viral; D012367:RNA, Viral; D012263:Ribonucleosides; D014764:Viral Proteins; D012254:Ribavirin