title: Effect of dopamine-beta-hydroxylase inhibition on cerebral vasospasm in the cat.
abstract: Inhibitors of dopamine beta hydroxylase (DBH) administered intraperitoneally were shown to prevent spasm of the basilar artery caused by blood application in cats. A low or nondetectable blood DBH activity level may be related to the absence of spasm. In several instances, however, moderate spasm did occur with a low blood DBH activity level. Possible mechanisms for these findings are discussed.
mesh_terms: D000818:Animals; D001488:Basilar Artery / Q000187:drug effects / Q000294:innervation; D002415:Cats; D004221:Disulfiram / Q000494:pharmacology; D004299:Dopamine beta-Hydroxylase / Q000037:antagonists & inhibitors*; D005260:Female; D005669:Fusaric Acid / Q000494:pharmacology; D002546:Ischemic Attack, Transient / Q000188:drug therapy / Q000201:enzymology*; D008297:Male; D013564:Sympathetic Nervous System / Q000201:enzymology
chemical_list: D004299:Dopamine beta-Hydroxylase; D005669:Fusaric Acid; D004221:Disulfiram