Urolithiasis induced with DL-3,a-dimethyltyrosine methylester HCl. I. A scanning electron microscopic investigation.
Scanning electron microscopic investigations on rats subjected to DL-3,a-dimethyltyrosine methylester HCl treatment, indicated that the drug in reference induces renal lesions substantiated by proximal tubular epithelial cell regression and eventual exfoliation, coupled by formation of 3,a-dimethyltyrosine calculi both in the upper and lower segments of the urinary tract. The development of calculi was found to be preceded by a moderate to massive precipitation of a fibrin-like substance intermixed with blood cells, and with an occasionally concomitant deposition of exfoliated cells of epithelial origin, to be succeeded by precipitation of crystals.
D000818:Animals; D004195:Disease Models, Animal; D007672:Kidney Cortex / Q000473:pathology; D007678:Kidney Glomerulus / Q000473:pathology; D008297:Male; D008855:Microscopy, Electron, Scanning; D051381:Rats; D014443:Tyrosine / Q000031:analogs & derivatives; D001743:Urinary Bladder / Q000473:pathology; D014545:Urinary Calculi / Q000139:chemically induced / Q000473:pathology*
D014443:Tyrosine