title: [Changes in the gonads and reproductive capacity of white rats after oral maneb poisoning].
abstract: Changes in the gonads and reproduction capacity of white rats following oral intoxication with maneb are studied. The preparation at doses 1/10, 1/50, 1/100 and 1/5000 LD50 is administered to the starting generation of white rats twice weekly. Changes in the gonads--biochemical, histological, histoenzymatic and electron microscopic--are established, as well as a capacity for reproduction of the starting I and II offspring. The results show a clearcut gonadotropic effect of the preparation, manifested by morphological changes in the starting generation, and by changes in fertility, gestation, survival and lactation of the starting I and II offspring.
mesh_terms: D000284:Administration, Oral; D000818:Animals; D005260:Female; D005298:Fertility / Q000187:drug effects; D006066:Gonads / Q000187:drug effects*; D007928:Lethal Dose 50; D008297:Male; D008344:Maneb / Q000506:poisoning*; D011041:Poisoning / Q000503:physiopathology; D011247:Pregnancy; D051381:Rats; D012098:Reproduction / Q000187:drug effects*; D013859:Thiocarbamates / Q000506:poisoning*
chemical_list: D013859:Thiocarbamates; D008344:Maneb
vernacular_title: Promeni v gonadite i v sposobnostta za reproduktsiia na beli plukhove sled oralna intoksikatsiia s maneb.