title: Insulin-binding antibodies in diabetic patients. Dynamic aspects of their formation.
abstract: Insulin-binding antibodies in serum of two groups of diabetics were followed up for a longer period of time. The first group had never been treated with exogenous insulin and showed a low antibody titer, with negligible changes in their level and diminishing of antibody production during ageing. Patients who had received insulin presented some differences: strong dependence of antibody titer on insulin dose; the very high doses, however, as well as a long period of treatment with insulin were accompanied with lowering of antibody concentration.
mesh_terms: D000328:Adult; D000367:Age Factors; D000368:Aged; D000906:Antibodies; D000917:Antibody Formation / Q000187:drug effects; D001666:Binding Sites, Antibody; D003920:Diabetes Mellitus / Q000188:drug therapy / Q000276:immunology*; D006801:Humans; D007328:Insulin / Q000494:pharmacology / Q000627:therapeutic use; D007330:Insulin Antibodies; D008875:Middle Aged
chemical_list: D000906:Antibodies; D007328:Insulin; D007330:Insulin Antibodies