Inhibition of sulpiride on the cephalic phase of gastric acid and gastrin secretion in duodenal ulcer patients.
In 13 patients with duodenal ulceration psychic stimulation with food resulted in a significant rise in gastric acid secretion and in serum gastrin. This rise was abolished when the patients were pre-treated with sulpiride, a non-sedative neuroleptic acting on the hypothalamus. These findings suggest that sulpiride, by virtue of its inhibitory effect on the cephalic phase of acid secretion, may be a useful adjunct in the treatment of duodenal ulcers.
D000293:Adolescent; D000328:Adult; D003864:Depression, Chemical; D004381:Duodenal Ulcer / Q000188:drug therapy*; D005502:Food; D005750:Gastric Juice / Q000378:metabolism*; D005755:Gastrins / Q000378:metabolism*; D006801:Humans; D008297:Male; D008875:Middle Aged; D013315:Stress, Psychological; D013469:Sulpiride / Q000378:metabolism*; D013997:Time Factors
D005755:Gastrins; D013469:Sulpiride