Protection of the skin of mice against irradiation with cyclotron-accelerated helium ions by 2-mercaptoethylamine.
Mouse skin was exposed to doses of 1 250 to 3 000 rad using a helium ion beam with modal LET of 15 keV per micron. The skin reactions were evaluated for mice treated with a topical application of 10% MEA in a cream base or a placebo 15 minutes before irradiation. A comparison of the skin reactions indicated that the MEA treatment resulted in a DMF of at least 1.2. The implication for radiation therapy was discussed.
D000287:Administration, Topical; D000818:Animals; D005260:Female; D006371:Helium; D007477:Ions; D008624:Mercaptoethylamines / Q000008:administration & dosage / Q000627:therapeutic use*; D051379:Mice; D011829:Radiation Dosage; D011833:Radiation Injuries, Experimental / Q000517:prevention & control*; D011837:Radiation-Protective Agents; D011868:Radioisotopes; D012867:Skin / Q000528:radiation effects*
D007477:Ions; D008624:Mercaptoethylamines; D011837:Radiation-Protective Agents; D011868:Radioisotopes; D006371:Helium