Influence of anesthesia on the rate of insulin biosynthesis.
Rates of insulin and total pancreatic protein biosynthesis were investigated by means of 1-14C-glycine under thiopental-induced deep anesthesia and thalamonal-induced neuroleptanalgesia. Blood levels of insulin and 11-OCS were also investigated. It was shown that both anesthetics - thalamonal and thiopental - inhibited rates of insulin synthesis and decrease its secretion. Only thiopental reduced the 11-OCS blood level. Changes of rate of insulin synthesis were observed on the background of inhibition of biosynthesis of total pancreatic proteins. But despite the absence of specific changes in the rate of insulin biosynthesis as compared to total pancreatic protein synthesis under both types of anesthesia, deep thiopental-induced anesthesia resulted in more severe changes in the biosynthesis of hormone and total proteins neuroleptanalgesia, since the latter induced only slight inhibition of rate of its synthesis.
D015062:11-Hydroxycorticosteroids / Q000097:blood; D000758:Anesthesia; D000777:Anesthetics / Q000494:pharmacology; D000818:Animals; D002850:Chromatography, Gel; D007328:Insulin / Q000096:biosynthesis* / Q000097:blood; D010179:Pancreas / Q000187:drug effects / Q000378:metabolism; D051381:Rats; D013874:Thiopental / Q000494:pharmacology
D015062:11-Hydroxycorticosteroids; D000777:Anesthetics; D007328:Insulin; D013874:Thiopental