Intravenous infusion of salbutamol in the treatment of asthma.
The effects of i.v. infusion of increasing rates of salbutamol for up to 4 h were documented in ten convalescent asthmatic patients. 2 The major bronchodilator effect was seen at 4.16 mug/minute. A small further improvement occurred at infusion rates up to 25.0 mug/min but was not significantly better than that seen at the lower infusion rate. 3 Cardiovascular effects were minimal after 60 min at the lower rate and even at 25.0 mug/min mean heart rate rose by only 17.1 beats/minute. All patients tolerated the 4 h infusion well. 4 It is concluded that i.v. infusion of salbutamol may be a useful addition to the treatment of the patient with a severe attack of asthma.
D000328:Adult; D000420:Albuterol / Q000008:administration & dosage* / Q000494:pharmacology / Q000627:therapeutic use; D001249:Asthma / Q000188:drug therapy* / Q000503:physiopathology; D001794:Blood Pressure / Q000187:drug effects; D005260:Female; D005541:Forced Expiratory Volume; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D007263:Infusions, Parenteral; D008297:Male; D008875:Middle Aged; D010366:Peak Expiratory Flow Rate; D013997:Time Factors; D014797:Vital Capacity
D000420:Albuterol