[Toxicity of ochratoxin A. II.--Effects of treatment on the progeny (F1 and F2) of intoxicated rats (author's transl)].
A group of pregnant rats is given a total of 5 mg/kg of ochratoxin A orally for two (lot A) and four (lot B) days. Treatment begins at day 8 post coitum for both lots. The progeny of these females are recorded and studied (F1 and F2). A description of litter size and ponderal growth of F1 individuals shows the results of the effects of the treatment of the mothers on this generation: reduced litters and late growth. Moreover, there is a high proportion of hydrocephalus which affects only the males. Finally, no effect was observed on F2 animals.
D000284:Administration, Oral; D000818:Animals; D000831:Animals, Newborn; D001724:Birth Weight; D001835:Body Weight; D005260:Female; D006849:Hydrocephalus / Q000139:chemically induced; D008098:Litter Size; D008297:Male; D009793:Ochratoxins / Q000008:administration & dosage / Q000633:toxicity*; D011041:Poisoning / Q000235:genetics; D011247:Pregnancy; D051381:Rats
D009793:Ochratoxins
Toxicité de l'ochratoxine A. II.--Effets du traitement sur la descendance (F1 et F2) de rattes intoxiquées