Hydantoin derivatives and malignancies of the haemopoietic system.
Two patients are described who developed malignant lymphoma (lymphosarcoma) after diphenylydantoin therapy because of epilepsy. Malignant lymphoma in a few patients receiving this medication has been described earlier. The literature has been reviewed and discussed recently by Rausing and Trell (2).
D000328:Adult; D004827:Epilepsy / Q000188:drug therapy; D006413:Hematopoietic System; D006801:Humans; D008228:Lymphoma, Non-Hodgkin / Q000139:chemically induced*; D008297:Male; D008875:Middle Aged; D010672:Phenytoin / Q000009:adverse effects* / Q000627:therapeutic use
D010672:Phenytoin