[Spontaneous and induced variability in Actinomyces rubiginosohelvolus, a new producer of the antibiotic rubomycin].
Mutants possessing 3 times higher activity as compared to the initial culture were obtained as a result of selection of active variants of Act. rubiginosonelvolus, a new organism producing rubomycin against the background of variation induced by N-methyl-N1-nitro-N-nitrozoguinidine, diethylsulphate and their combinations. Further selection among the mutants stable to 6-mercaptopurine and riboflavine resulted in obtaining an active culture No. 3912 at least 7 times more active with respect to rubomycin production than the initial soil culture.
D000903:Antibiotics, Antineoplastic / Q000096:biosynthesis*; D003037:Cobalt Radioisotopes; D014644:Genetic Variation / Q000187:drug effects* / Q000528:radiation effects; D008769:Methylnitronitrosoguanidine / Q000494:pharmacology; D009154:Mutation / Q000187:drug effects / Q000528:radiation effects; D011830:Radiation Effects; D013302:Streptomyces / Q000187:drug effects* / Q000528:radiation effects; D013431:Sulfates / Q000494:pharmacology
D000903:Antibiotics, Antineoplastic; D003037:Cobalt Radioisotopes; D013431:Sulfates; D008769:Methylnitronitrosoguanidine
Spontannaia i indutsirovannaia izmenchivost' Actinomyces rubiginosohelvolus--novogo produtsenta antibiotika rubomitsina.