On the effect of prednisolone on hamster bone.
Over a period of 10.8 weeks 0.4, 4.0 or 40.0 mg, respectively of prednisolone bisuccinate/kg/day were injected intramuscularly into Syrian golden hamsters with a body weight of about 100 g. The dosage of 4.0 mg of prednisolone/kg did not produce any osteoporotic changes. The modulus of elasticity and the fracture load of the bones under investigation did not differ from the values obtained in control animals. At a dosage of 0.4 mg of prednisolone/kg/day the values of analysis (density, ash/cm3, calcium/cm3 and hydroxyproline/cm3) decreased by 5-8 percent, and at a dosage of 40.0 mg of prednisolone/kg/day even by 20-34 per cent as compared with the control group. The modulus of elasticity and the fracture load were significantly changed.
D000818:Animals; D001842:Bone and Bones / Q000187:drug effects*; D006224:Cricetinae; D004548:Elasticity; D005269:Femur / Q000187:drug effects; D005598:Fractures, Spontaneous; D010024:Osteoporosis / Q000139:chemically induced; D011239:Prednisolone / Q000008:administration & dosage / Q000009:adverse effects*; D011817:Rabbits
D011239:Prednisolone