Persistent reversal of severe systemic hypertension after prolonged toxic reaction to hydralazine.
A patient with severe progressive hypertension was treated with parenteral hexamethonium and large dosages of hydralazine. He developed a 'hydralazine syndrome', the etiology of which was not recognized for approximately 9 months. Upon discontinuance of hydralazine the patient was easily kept normotensive for over 20 years, using only small dosages of cryptenamine, reserpine and/or bendroflumethiazide. Similar observations are cited in the literature in seven other patients who were treated with hydralazine for significant periods of time after toxic symptoms occurred.
D000328:Adult; D004342:Drug Hypersensitivity; D004359:Drug Therapy, Combination; D006584:Hexamethonium Compounds / Q000627:therapeutic use; D006801:Humans; D006830:Hydralazine / Q000009:adverse effects* / Q000627:therapeutic use; D006973:Hypertension / Q000188:drug therapy*; D008297:Male; D013997:Time Factors
D006584:Hexamethonium Compounds; D006830:Hydralazine