title: Changes in drug metabolism with increasing age: 1. warfarin binding and plasma proteins.
abstract: 1 A decrease was found in the binding capacity of elderly people for warfarin. 2 The decrease in binding correlated with a fall in plasma albumin concentrations. 3 No changes in the association constant were observed.
mesh_terms: D000328:Adult; D000368:Aged; D000375:Aging; D005260:Female; D006801:Humans; D008297:Male; D011485:Protein Binding; D012709:Serum Albumin / Q000032:analysis / Q000378:metabolism*; D014859:Warfarin / Q000378:metabolism*
chemical_list: D012709:Serum Albumin; D014859:Warfarin