A study of the influence of various diagnostic and therapeutic procedures applied to a murine squamous carcinoma on its metastatic behaviour.
An experimental tumour system for the study of metastasis has been developed using a syngeneically transplanted murine squamous carcinoma of spontaneous origin. Implants of the tumour, which does not elicit a significant immune response, grew and metastasized regularly to regional lymph nodes and lungs, in a manner comparable with that of the more malignant types of human epithelioma. The system has been used to test the influece of pre-operative irradiation, regional lymph node excision, tumour biopsy and manipulation, on metastasis. Of these, only pre-operative irradiation with 2000 rad 24 h before tumour excision produced a significant differential effect--a lower incidence of metastasis. By contrast, local radiation therapy sufficient to cause complete tumour regression but insufficient to achieve long-term local cure was shown to result in accelerated metastasis. A highly significant inhibition of metastasis was observed with the drug ICRF 159, but histological features suggested that its anti-metastatic effect in this system did not depend on morphological changes which might prevent dissemination of tumour cells.
D000818:Animals; D001706:Biopsy; D002294:Carcinoma, Squamous Cell / Q000532:radiotherapy / Q000601:surgery / Q000628:therapy; D004195:Disease Models, Animal; D005260:Female; D006801:Humans; D007114:Immunization; D008197:Lymph Node Excision; D051379:Mice; D008815:Mice, Inbred Strains; D009362:Neoplasm Metastasis / Q000517:prevention & control*; D009368:Neoplasm Transplantation; D009374:Neoplasms, Experimental / Q000628:therapy; D011929:Razoxane / Q000627:therapeutic use; D014185:Transplantation, Isogeneic
D011929:Razoxane