title: Kininogen deficiency in Fitzgerald trait: role of high molecular weight kininogen in clotting and fibrinolysis.
abstract: Plasma from an asymptomatic person with defects in blood coagulation, release of kinin, and evolution of fibrinolytic activity upon contact with a foreign surface was deficient in kininogen. The coagulation defect was identified as "Fitzgerald trait." A preparation of high molecular weight kininogen repaired the defects in clotting, kinin release and fibrinolysis, but a preparation of low molecular weight kininogen did not. Therefore, Fitzgerald factor appears to be a high molecular weight kininogen. The site of action of the kininogen appears to be after that of activated Hageman factor and kallikrein in the generation of clot-promoting activity through activation of plasma thromboplastin antecedent (PTA).
mesh_terms: D000328:Adult; D001777:Blood Coagulation; D001778:Blood Coagulation Disorders / Q000097:blood* / Q000235:genetics / Q000378:metabolism; D001780:Blood Coagulation Tests; D005164:Factor IX / Q000032:analysis; D005169:Factor VIII / Q000032:analysis; D005172:Factor XI / Q000032:analysis; D005174:Factor XII / Q000032:analysis; D005260:Female; D005342:Fibrinolysis; D006801:Humans; D007704:Kininogens / Q000097:blood*; D007705:Kinins / Q000378:metabolism; D008297:Male; D008970:Molecular Weight; D010375:Pedigree; D011288:Prekallikrein
chemical_list: D007704:Kininogens; D007705:Kinins; D005169:Factor VIII; D005164:Factor IX; D005174:Factor XII; D005172:Factor XI; D011288:Prekallikrein