[The effect of a combination of 1-(4'-hydroxyphenyl)-2-methyl-aminopropanol-(1)-hydrochloride with a nucleotide containing heart muscle extract on the heart and circulatory system of the dog].
The heamodynamic activity of Carnigen, which is a blood pressure stabilizer consisting of 1-(4'-hydroxyphenyl)-2-methylaminopropanol-(1)-hydrochloride (Suprifen) and a nucleotide containing heart muscle extract, was investigated in 15 anaesthetized dogs following intraduodenal application (0.3--1--3 mg/kg body weight). The following results were obtained: 1. The stroke volume and cardiac output were raised significantly exhibiting a dose dependent activity follwoing Carnigen application. 2. The cardiac work exhibited a dose dependent rise which was significant after 3 mg/kg. 3. The contractility of the left ventricle increased following each of the tested dosages. This was expressed by a significant rise in the dp/dt value as well as in the quotient (see article). 4. The mean femoral blood pressure exhibited a moderate rise in the test range from 0.3--3 mg/kg. 5. The heart rate increased by a few beats follwoing doses of 0.3--1 mg/kg. 6. The total peripheral resistance was reduced in a dose dependent manner. 7. The respiration volume was slightly increased following 0.3 and 1 mg/kg Carnigen, 3 mg/kg caused a quite moderate respiration stimulation.
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D002302:Cardiac Output / Q000187:drug effects; D004285:Dogs; D004338:Drug Combinations; D004809:Ephedrine / Q000031:analogs & derivatives* / Q000494:pharmacology; D006321:Heart / Q000187:drug effects*; D006339:Heart Rate / Q000187:drug effects; D006439:Hemodynamics / Q000187:drug effects*; D009200:Myocardial Contraction / Q000187:drug effects; D009206:Myocardium; D009711:Nucleotides / Q000494:pharmacology*; D013268:Stimulation, Chemical; D013997:Time Factors; D014020:Tissue Extracts / Q000494:pharmacology; D014655:Vascular Resistance / Q000187:drug effects
D004338:Drug Combinations; D009711:Nucleotides; D014020:Tissue Extracts; D004809:Ephedrine
Wirkung einer Kombination aus 1-(4'-Hydroxyphenyl)-2-methylaminopropanol-(1)-hydrochlorid mit einem nukleotidhaltigen Herzmuskelextrakt auf das Herz- und Kreislaufsystem des Hundes