Step conductance increases in bilayer membranes induced by antibody-antigen-complement action.
A sharp rise in the electrical conductance of lipid bilayer membranes was observed following the addition of antigen (bovine serum), antibody (rabbit anti-bovine serum), and complement to the neighboring aqueous phases. At low concentrations, step increases in the conductivity occurred which are consistent with the appearance of about 2.2 nm holes in the membrane. Probably attack or lysis of the lipid bilayer by complement is responsible.
D000818:Animals; D000937:Antigen-Antibody Reactions; D001665:Binding Sites; D002417:Cattle; D003165:Complement System Proteins; D004553:Electric Conductivity; D008081:Liposomes; D046911:Macromolecular Substances; D008567:Membranes, Artificial; D008954:Models, Biological; D009994:Osmolar Concentration; D011485:Protein Binding
D008081:Liposomes; D046911:Macromolecular Substances; D008567:Membranes, Artificial; D003165:Complement System Proteins