title: [Erythrokeratodermia variabilis. Report of 3 clinical cases and evaluation of the topical retinoic acid treatment].
abstract: Three cases of erythrokeratodermia variabilis are presented, the first one being a female aged 16 and the two others being a woman aged 27 and her son aged 2. Familial relationship between case 1 and the others did not exist. The inheritance pattern was apparently autosomal recessive in the first case and autosomal dominant in cases 2 and 3. The dermatological lesions were the classically described for the disease. The evolution had not been influenced by puberty in cases 1 and 2 or by the pregnancy in case 2. Topical acid vitamin A (0.1 g. per cent cream) was used on hyperkeratotic areas in every patient with substantial reduction of the lesions. However these beneficial results were not long-lasting after discontinuance of that therapy.
mesh_terms: D000293:Adolescent; D000328:Adult; D002675:Child, Preschool; D005260:Female; D005799:Genes, Dominant; D005808:Genes, Recessive; D006801:Humans; D008297:Male; D009824:Ointments; D014212:Tretinoin / Q000008:administration & dosage / Q000627:therapeutic use*; D014801:Vitamin A / Q000031:analogs & derivatives*
chemical_list: D009824:Ointments; D014801:Vitamin A; D014212:Tretinoin
vernacular_title: Eritroqueratodermia Variabilis. Apresentacao de três casos clínicos e apreciacao do tratamento com tópico com ácido retinoico