The effect of brocresine (NSD-1055) on basal and stimulated gastric acid secretion in chickens.
The effect of the histidine decarboxylase inhibitor 4-bromo-3-hydroxybenzyloxyamine-dihydrogenphosphate (brocresine, NSD-1055) on basal and histamine-, pentagastrin- and carbachol-stimulated gastric acid secretion was investigated in unanaesthetized gastric fistula chickens. Basal secretion was initially reduced by brocresine for 45 min and then slightly stimulated for 90 min. The histamine stimulated gastric secretion was competitively inhibited by brocresine. The acid response to low doses of pentagastrin and carbachol was enhanced, that to high doses unchanged. The results can be explained in the light of the assumption that a metabolic product of brocresine, 3-hydroxy-4-bromo-benzyl-alcohol stimulates gastric acid secretion.
D000818:Animals; D001958:Brocresine / Q000494:pharmacology*; D002217:Carbachol / Q000494:pharmacology; D002645:Chickens; D003408:Cresols / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D004347:Drug Interactions; D005260:Female; D005747:Gastric Fistula / Q000503:physiopathology; D005750:Gastric Juice / Q000378:metabolism*; D006632:Histamine / Q000494:pharmacology; D010418:Pentagastrin / Q000494:pharmacology; D013997:Time Factors
D003408:Cresols; D001958:Brocresine; D006632:Histamine; D002217:Carbachol; D010418:Pentagastrin