[The postnatal reaction of the albino rat pigment epithelium after administration of chloroquindiphosphate].
The development of pigment granules has been studied in 0...5 day old normal albino-rats and after a single injection of chloroquinediphosphat. During the postnatal time the pigment epithelial cell changes structurally. The basal region of the epithelium containes lipoidvacuoles and later on glycogen. The apical region form long skin projections that enclose the developing inner segments of photoreceptor cells. The pigment granules develop normally until the stage of melanin deposition. The lamellated premelanosomes are equipped by helical structures. The development of premelanosomes are not disturbed, by chloroquinediphosphate blocking the protein synthesis in the cell. The drug produce lamellated vacuoles inside the cell arising from the ergastoplasm. Also the extracellular space is enlarged. A significant increase or decrease in the number of phagosomes in the pigment epithelial cells after administration of the drug does not occur as compared to the cells of untreated animals.
D000417:Albinism; D000818:Animals; D000831:Animals, Newborn; D002738:Chloroquine / Q000494:pharmacology*; D010857:Pigment Epithelium of Eye / Q000187:drug effects* / Q000648:ultrastructure; D051381:Rats
D002738:Chloroquine
Die Reaktion des Pigmentepithels der Albinoratte nach Gaben von Chloroquinidiphosphat während der Postnatalperiode