Hydroxocobalamin therapy of cyanide intoxication in guinea pigs.
The efficacy of hydroxocobalamin (vitamin B12a) as a specific, nontoxic antidote in acute cyanide poisoning was tested. Guinea pigs receiving lethal intravenous NaCN injections were treated with either vitamin B12a or saline solution. There was a statistically significant antidotal effect of the vitamin. No toxic effect was observed with large doses of the vitamin.
D000818:Animals; D000931:Antidotes / Q000627:therapeutic use; D003486:Cyanides / Q000506:poisoning*; D006168:Guinea Pigs; D006879:Hydroxocobalamin / Q000008:administration & dosage / Q000627:therapeutic use* / Q000633:toxicity
D000931:Antidotes; D003486:Cyanides; D006879:Hydroxocobalamin