Sodium cellulose phosphate-induced increment in urinary calcium/magnesium ratio.
In 19 adult patients, with renal stones containing calcium and hypercalciuria, urinary calcium and magnesium excretion and urinary calcium/magnesium ratio was investigated before and during 4 days of treatment with sodium cellulose phosphate. Urinary magnesium excretion fell following sodium cellulose phosphate therapy in all but 1 patient investigated: in 9 patients by less than 50% and in 10 by more than 50% of the pretreatment values. In the latter group of patients urinary calcium/magnesium ratio increased significantly from the mean values ( +/- SD) 3.2 +/- 1.1 to 6.77 +/- 6.9. In 6 patients serum magnesium absorption is suggested, and routine serum and urinary magnesium analysis with the early treatment of magnesium deficiency in patients treated with sodium cellulose phosphate are recommended.
D000328:Adult; D002118:Calcium / Q000652:urine*; D002411:Cation Exchange Resins / Q000009:adverse effects; D002482:Cellulose / Q000009:adverse effects / Q000031:analogs & derivatives* / Q000627:therapeutic use; D005260:Female; D006801:Humans; D007669:Kidney Calculi / Q000188:drug therapy / Q000652:urine*; D008274:Magnesium / Q000652:urine*; D008275:Magnesium Deficiency / Q000139:chemically induced; D008297:Male; D008875:Middle Aged; D009943:Organophosphorus Compounds / Q000009:adverse effects*
D002411:Cation Exchange Resins; D009943:Organophosphorus Compounds; D002482:Cellulose; C008881:phosphocellulose; D008274:Magnesium; D002118:Calcium