[Blockade of the dopamine receptor: a possible mechanism of action of antipsychotic drugs (author's transl)].
Antipsychotic drugs of various types inhibit dopamine-sensitive adenylate cyclase (EC 4.6.1.1) while structurally related drugs that were not clinically effective as antipsychotic drugs were almost inactive. These results are discussed in relation to the suggestion that antipsychotic activity may be related to the blockade of dopamine receptors in the brain.
D000262:Adenylyl Cyclases / Q000378:metabolism; D000818:Animals; D001921:Brain / Q000201:enzymology / Q000378:metabolism; D004298:Dopamine / Q000378:metabolism*; D006801:Humans; D051381:Rats; D011955:Receptors, Drug / Q000187:drug effects*; D014149:Tranquilizing Agents / Q000494:pharmacology*
D011955:Receptors, Drug; D014149:Tranquilizing Agents; D000262:Adenylyl Cyclases; D004298:Dopamine
Dopamin-Rezeptor-Blockade, ein möglicher Wirkungsmechanismus antipsychotisch wirksamer Pharmaka