Colchicine inhibition of the heparin-stimulated release of clearing-factor lipase from isolated fat-cells.
When isolated fat-cells are incubated at 25 degrees C in serum-based media containing glucose, insulin and heparin, the rise that occurs in the clearing-factor lipase activity of the incubation medium is inhibited by colchicine. The rise in the fat-cell clearing-factor lipase activity that occurs during similar incubations in the absence of heparin is not affected by colchicine.
D000273:Adipose Tissue / Q000187:drug effects* / Q000201:enzymology; D000818:Animals; D003078:Colchicine / Q000494:pharmacology*; D005947:Glucose / Q000378:metabolism; D006493:Heparin / Q000494:pharmacology*; D066298:In Vitro Techniques; D007328:Insulin / Q000494:pharmacology; D008071:Lipoprotein Lipase / Q000037:antagonists & inhibitors / Q000378:metabolism*; D008297:Male; D051381:Rats
D007328:Insulin; D006493:Heparin; D008071:Lipoprotein Lipase; D005947:Glucose; D003078:Colchicine