Bone lesions in early congenital syphilis.
A radiological study of bone changes in 112 children with congenital syphilis was undertaken. A similar number of normal children acted as a control group. Radiological examination of 5 syphilitic children showed that their bones were normal. Combined metaphyseal and periosteal lesions were the commonest bone disorders seen and are thus the most convincing radiological evidence of congenital syphilis. Transverse metaphyseal lucencies occur early in the disease, and with Wimburger's sign they are the prime evidence of pathology in syphilitic bone. Other radiographic changes are probably owing to minimal trauma in fragile disorganized bone. The occurrence of periosteal lesions alone has also been evaluated.
D001847:Bone Diseases / Q000000981:diagnostic imaging* / Q000209:etiology; D002114:Calcinosis / Q000000981:diagnostic imaging; D050723:Fractures, Bone / Q000150:complications; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007866:Leg; D010014:Osteolysis / Q000000981:diagnostic imaging; D010522:Periostitis / Q000000981:diagnostic imaging; D011859:Radiography; D013590:Syphilis, Congenital / Q000150:complications / Q000000981:diagnostic imaging*; D013977:Tibia / Q000000981:diagnostic imaging