[New pathogenetic aspects of hepatitis B in relation to finding HBAg inhibitor in the intestinal mucosa and human feces].
Hepatitis B antigen (HBAg) positive sera became negative after in vitro incubation with homogenates of human faeces or intestinal mucosa. This was found to occur in all sera tested by various methods. These findings suggest the existence in the human intestine of a substance able to inactivate the HBAg and that it is not an antibody or of the nature of interferon. The presence of an inhibitor could explain why B-type hepatitis is seldom if ever faecally transmitted and also the low oral infectiousness of the B virus.
D000914:Antibodies, Viral; D000917:Antibody Formation; D005243:Feces; D006509:Hepatitis B / Q000276:immunology*; D006511:Hepatitis B Antigens / Q000302:isolation & purification*; D006515:Hepatitis B virus / Q000276:immunology; D006801:Humans; D007413:Intestinal Mucosa / Q000276:immunology*
D000914:Antibodies, Viral; D006511:Hepatitis B Antigens
Nuovi aspetti patogenetici della epatite B in rapporto alla identificazione di un inibitore dell'HBAg presente nella mucosa intestinale e nelle feci umane