[Anti-inflammatory effects of ketoprofen - with special reference to inhibition of leukocyte migration].
It was observed that ketoprofen inhibited the increased vascular permeability induced by US-PF and in vitro leukocyte migration. The suppressive effect of ketoprofen on increased vascular permeability induced by US-PF was found to be the same as that of indomethacin. The effect of ketoprofen on the in vitro chemotaxis of rabbit peritoneal neutrophils was found to be the same as that of oxyphenbutazone and less than indomethacin. If the side effects of this drug are proven to be mild or not serious, and effective results are seen in clinical trials, ketoprofen may then be classified as a potent non-steroidal anti-inflammatory agent wifh analgesic actions in dysergic inflammation.
D000818:Animals; D000893:Anti-Inflammatory Agents; D001577:Benzophenones / Q000494:pharmacology*; D002199:Capillary Permeability / Q000187:drug effects; D002465:Cell Movement / Q000187:drug effects*; D066298:In Vitro Techniques; D007660:Ketoprofen / Q000494:pharmacology*; D007962:Leukocytes / Q000187:drug effects*; D011817:Rabbits
D000893:Anti-Inflammatory Agents; D001577:Benzophenones; D007660:Ketoprofen