[Cytogenetic studies of preinvasive lesions and invasive carcinomas of the cervix uteri. I. Numerical chromosome abnormalities (author's transl)].
Analysis of chromosome numbers of 9 dysplasias, 25 carcinomas in situ, 4 carcinomas in situ with microinvasion and 16 invasive squamous carcinomas (at least clinical stage I b) of the cervix uteri showed that the numerical deviations of the chromosome number cannot be differentiated in principle between the carcinoma in situ, carcinoma in situ with microinvasion and invasive squamous carcinoma groups. The only remarkable finding is that cells in the triploid region appear somewhat more frequently in the invasive squamous carcinoma group. The dysplasia group has in general less numerical chromosome deviations than the other three groups. Chromosome gains seldom occur in this group, chromosome losses appear to be a more frequent event.
D000328:Adult; D000368:Aged; D000782:Aneuploidy; D002278:Carcinoma in Situ / Q000235:genetics; D002294:Carcinoma, Squamous Cell / Q000235:genetics; D002869:Chromosome Aberrations; D005260:Female; D006801:Humans; D008875:Middle Aged; D011230:Precancerous Conditions / Q000235:genetics; D002583:Uterine Cervical Neoplasms / Q000235:genetics* / Q000473:pathology
Cytogenetische Untersuchungen an Praecancerosen und Carcinomen der Cervix uteri. I. Numerische Chromosomenanomalien