Anti-PP1Pk (anti-Tja) and habitual abortion.
Blood group incompatibility as a cause of early or habitual abortion has been a matter of much debate. However, the abortion rate in such cases is much higher than that found in the general population. Two sisters having the rare genotype pp and anti-PP1Pk (anti-Tja) in their serum were reported as having habitual abortions; a third sister, with a normal P group, had a normal obstetric history. The relationship of anti-PP1Pk (anti-Tja) to the high rate of habitual abortion was discussed and added support was given to the existing evidence that certain maternal blood group antibodies can affect embryos early in uterine life.
D000026:Abortion, Habitual / Q000209:etiology / Q000235:genetics / Q000276:immunology*; D000328:Adult; D001789:Blood Group Antigens; D001787:Blood Group Incompatibility; D005260:Female; D005838:Genotype; D006801:Humans; D010127:P Blood-Group System; D011247:Pregnancy
D001789:Blood Group Antigens; D010127:P Blood-Group System