Species-specific hypoglycemic activity of triphenylphosphoranylideneacetophenones.
The species-specific hypoglycemic activity of two 2-triphenylphosphoranylideneacetophenones is described. 2-Triphenylphosphoranylideneacetophenone (SK&F 45359) and 2-triphenylphosphoranylidene-m-trifluoromethyl-acetophenone (SK&F 62775) were hypoglycemic in various rat models, but failed to exhibit hypoglycemic activity in other species.
D000098:Acetophenones / Q000494:pharmacology*; D000818:Animals; D003921:Diabetes Mellitus, Experimental / Q000188:drug therapy*; D004285:Dogs; D005260:Female; D006168:Guinea Pigs; D007003:Hypoglycemia / Q000139:chemically induced*; D007004:Hypoglycemic Agents; D007328:Insulin / Q000097:blood; D008112:Liver Glycogen / Q000096:biosynthesis / Q000378:metabolism; D008297:Male; D009943:Organophosphorus Compounds / Q000494:pharmacology; D011817:Rabbits; D051381:Rats; D013045:Species Specificity; D013329:Structure-Activity Relationship; D013730:Terphenyl Compounds / Q000494:pharmacology
D000098:Acetophenones; D007004:Hypoglycemic Agents; D007328:Insulin; D008112:Liver Glycogen; D009943:Organophosphorus Compounds; D013730:Terphenyl Compounds; C011618:2-triphenylphosphoranylidene-m-trifluoromethylacetophenone