title: Concentration of biologically active 5-fluorouracil in general circulation during continuous portal infusion in man: a preliminary report.
abstract: 5-Fluorouracil (5-FU) was administered to 8 patients with malignant liver tumours either by regional portal or general intravenous infusion. During continuous portal infusion of 15 mg 5-FU/kg/24 h, systemic serum-concentrations were generally below 100 ng/ml and no side-effects were seen. Intravenous infusion of the same dose was accompanied by serum-concentrations above 100 ng/ml and bone-marrow depression. This preliminary study indicates that there are better prerequisites for high anti-toumour effect and low frequency of side-effects during portal infusion of 5-FU than during general intravenous administration to patients with liver tumours.
mesh_terms: D005472:Fluorouracil / Q000008:administration & dosage* / Q000097:blood / Q000627:therapeutic use; D006801:Humans; D007263:Infusions, Parenteral; D008113:Liver Neoplasms / Q000097:blood / Q000098:blood supply / Q000188:drug therapy*; D011169:Portal Vein
chemical_list: D005472:Fluorouracil