Protection by cerium chloride on CCl4-induced hepatotoxicity.
Pretreatment of rats with cerium chloride, an inhibitor of the DMES, protect against CCl4 intoxication. The protection was obtained against the fatty infiltration in the liver, the decrease of triglyceride secretion from the liver into the plasma compartment, the polysomal disaggregation and the rise of serum transaminases.
D000410:Alanine Transaminase / Q000032:analysis; D000818:Animals; D001219:Aspartate Aminotransferases / Q000032:analysis; D002252:Carbon Tetrachloride Poisoning / Q000150:complications / Q000378:metabolism / Q000473:pathology / Q000517:prevention & control*; D002563:Cerium / Q000494:pharmacology*; D056486:Chemical and Drug Induced Liver Injury / Q000209:etiology*; D008099:Liver / Q000187:drug effects* / Q000378:metabolism; D008297:Male; D011132:Polyribosomes / Q000187:drug effects; D051381:Rats; D014280:Triglycerides / Q000097:blood / Q000378:metabolism
D014280:Triglycerides; D002563:Cerium; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase