Desoxyribonuclease activity in the serum and spleen of rats with mycoplasma induced arthritis.
The endodesoxyribonuclease and exodesoxyribonuclease activities were measured in the spleen cytoplasma fraction and serum of rats with mycoplasma induced arthritis and adjuvant arthritis. A higher exonuclease activity was found in the spleen cytoplasma of adjuvant arthritis rats. During the regression of mycoplasma arthritis an increased activity of exonuclease was detected in the serum, but in the acute stage of inflammation the exonuclease activity was similar to the control values. A higher endonuclease activity was found in the spleen cytoplasma fraction of rats with mycoplasma arthritis. The possible origin of the endonuclease and its role in arthritis are discussed.
D000818:Animals; D001170:Arthritis, Infectious / Q000201:enzymology* / Q000209:etiology; D003851:Deoxyribonucleases / Q000097:blood / Q000378:metabolism*; D004195:Disease Models, Animal; D009175:Mycoplasma Infections / Q000150:complications*; D051381:Rats; D013154:Spleen / Q000201:enzymology*
D003851:Deoxyribonucleases