[Study of the embrotoxic properties of the repellent diethyltoluamide].
With application to the skin of an albino female-rat over the whole period of its pregnancy of the repellent diethyltolueneamide (DETA) in doses of 100 and 1000 mg/kg the overall embryonal fatality was found to go up, the size and weight of the rattlings to be down; there was recorded a lagging development of the newborns and a high postnatal death rate. The preparation could easily overcome the placental barrier, it was demonstrable in the placenta, fetuses, as well as in the bodies of newborn rattlings, even 3 months after their birth.
D000287:Administration, Topical; D000818:Animals; D001549:Benzamides / Q000633:toxicity*; D001835:Body Weight / Q000187:drug effects; D003671:DEET / Q000032:analysis / Q000633:toxicity*; D004305:Dose-Response Relationship, Drug; D010064:Embryo Implantation / Q000187:drug effects; D020964:Embryo Loss / Q000139:chemically induced; D004622:Embryo, Mammalian / Q000187:drug effects*; D005260:Female; D005313:Fetal Death / Q000139:chemically induced; D008431:Maternal-Fetal Exchange / Q000187:drug effects; D011247:Pregnancy; D051381:Rats; D013997:Time Factors
D001549:Benzamides; D003671:DEET
Izuchenie émbriotoksicheskikh svoĭstv repellenta diétiltoluamida