In vivo inhibition of cholesterol uptake in rabbit aortas by 7-ketocholesterol.
The iv injection of 7-ketocholesterol into rabbits, made soluble by combining with bile salts, inhibited cholesterol uptake by the aorta. However, the inhibition was not as marked or as uniform as previously demonstrated in in vitro experiments. This difference may have been the result of lower plasma concentrations of 7-ketocholesterol in the injected animals. Gastric feeding of 7-ketocholesterol failed to inhibit aortic cholesterol uptake, probably because of inadequate plasma concentrations of the inhibitory steroid. The results suggest that the mechanism of 7-ketocholesterol on aortic cholesterol uptake is through competitive inhibition.
D000818:Animals; D001011:Aorta / Q000378:metabolism*; D001692:Biological Transport / Q000187:drug effects; D002784:Cholesterol / Q000031:analogs & derivatives* / Q000097:blood / Q000378:metabolism* / Q000494:pharmacology; D003864:Depression, Chemical; D005260:Female; D007653:Ketocholesterols; D007664:Ketosteroids / Q000097:blood / Q000378:metabolism / Q000494:pharmacology*; D011817:Rabbits
D007653:Ketocholesterols; D007664:Ketosteroids; D002784:Cholesterol; C003001:7-ketocholesterol