The effect of corticosteroids and hemicholinium-3 on choline uptake and incorporation into acetylcholine in rat diaphragm.
The glucocorticoids prednisolone and dexamethasone antagonize the inhibition by hemicholinium-3 of both the rate of choline uptake and the incorporation of choline into acetylcholine in the rat diaphragm. Aldosterone has no such effects. It is concluded that the beneficial effect of glucocorticoids in the treatment of myasthenia gravis may be due not only to immunosuppression, but also to some direct effect on presynaptic events perhaps via a choline carrier or an enzyme of choline metabolism.
D000109:Acetylcholine / Q000096:biosynthesis*; D000305:Adrenal Cortex Hormones / Q000494:pharmacology*; D000450:Aldosterone / Q000494:pharmacology; D000818:Animals; D002794:Choline / Q000378:metabolism*; D003864:Depression, Chemical; D003907:Dexamethasone / Q000494:pharmacology; D003964:Diaphragm / Q000378:metabolism*; D005260:Female; D006426:Hemicholinium 3 / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D066298:In Vitro Techniques; D011239:Prednisolone / Q000494:pharmacology; D051381:Rats
D000305:Adrenal Cortex Hormones; D006426:Hemicholinium 3; D000450:Aldosterone; D003907:Dexamethasone; D011239:Prednisolone; D002794:Choline; D000109:Acetylcholine