Mutants of Saccharomycopsis lipolytica defective in lysine catabolism.
Wild-type strains of Saccharomycopsis lipolytica are able to use lysine as a carbon or a nitrogen source, but not as a unique source for both. Mutants were selected that could not use lysine either as a nitrogen or as a carbon source. Some of them, however, utilized N-6-acetyllysine or 5-aminovaleric acid. Many of the mutants appeared to be blocked in both utilizations, suggesting a unique pathway for lysine degradation (either as a carbon or as a nitrogen source). Genetic characterization of these mutants was achieved by complementation and recombination tests.
D015074:2-Aminoadipic Acid / Q000378:metabolism; D001203:Ascomycota / Q000378:metabolism*; D005816:Genetic Complementation Test; D008040:Genetic Linkage; D008239:Lysine / Q000031:analogs & derivatives / Q000378:metabolism*; D009154:Mutation; D010641:Phenotype; D010875:Pipecolic Acids / Q000378:metabolism; D011995:Recombination, Genetic; D012442:Saccharomycopsis / Q000254:growth & development / Q000378:metabolism*; D014631:Valerates / Q000378:metabolism
D010875:Pipecolic Acids; D014631:Valerates; D015074:2-Aminoadipic Acid; D008239:Lysine