Platelet-surface interaction: effects of dextran 70 on platelet retention in extracorporeal surfaces.
Dextran 70 infusion into dogs prevents platelet adhesion to extracorporeal surfaces as effectively as direct coating of the surfaces with albumin. This is demonstrated by two experimental approaches. One of these involves a detailed analysis in 14 mongrel dogs of the effects of hemoperfusion on the systemic platelet levels, hematocrits, and dextran concentrations. The second approach is in the form of 23 platelet retention tests carried out in four mongrel dogs.
D000818:Animals; D001772:Blood Cell Count; D001792:Blood Platelets / Q000502:physiology*; D003911:Dextrans / Q000097:blood / Q000494:pharmacology*; D004285:Dogs; D005343:Fibrinolytic Agents; D006355:Heart-Lung Machine / Q000295:instrumentation*; D006400:Hematocrit; D010973:Platelet Adhesiveness / Q000187:drug effects*; D011126:Polypropylenes; D012965:Sodium Chloride / Q000494:pharmacology; D013499:Surface Properties
D003911:Dextrans; D005343:Fibrinolytic Agents; D011126:Polypropylenes; D012965:Sodium Chloride