Circulatory regulation in anuric rats: anuria and haemorrhagic hypotension.
In rats made anuric by ureteral ligation or by creating a bladder-caval venous shunt, cardiac index increased and total peripheral resistance decreased proportionally to the change in the serum NPN level. Circulating blood and plasma volume did not change. In ureteral-ligated or bladder-caval venous-shunted rats, cardiac output and its organ fractions were determined by SAPIRSTEIN'S technique. In the ureteral-ligated animals, vasoconstriction in the kidneys, and vasodilation in the skin were found. After bladder-caval shunt, vasodilatation developed in the myocardium, gut, skin and carcass. After ureteral ligation, posthaemorrhagic shifting decreased mainly the renal flow, while after a bladder-caval venous shunt, mainly the renal and intestinal flows.
D000818:Animals; D001002:Anuria / Q000503:physiopathology*; D001794:Blood Pressure; D001806:Blood Urea Nitrogen; D001810:Blood Volume; D001815:Bloodletting / Q000009:adverse effects; D002200:Capillary Resistance; D002302:Cardiac Output; D002319:Cardiovascular System / Q000503:physiopathology*; D006400:Hematocrit; D007022:Hypotension / Q000209:etiology / Q000503:physiopathology*; D007668:Kidney / Q000502:physiology; D008297:Male; D011188:Potassium / Q000097:blood; D051381:Rats; D011919:Rats, Inbred Strains; D012039:Regional Blood Flow; D014513:Ureter / Q000502:physiology; D001743:Urinary Bladder / Q000601:surgery; D014684:Venae Cavae / Q000601:surgery
D011188:Potassium