Spontaneous reversibility of advanced toxic liver cirrhosis.
The spontaneous restoration of liver cirrhosis induced by 6 and 9 month CC14 treatment has been studied. The OH-proline content of the liver stroma, the DNA content of the parenchyma, and the Co/DNA ratio were determined. Observations lasted for 4 months after completion of treatment. Cirrhosis developed after 6 month, CC14 administration was reversible in 3--4 months after the discontinuation of treatment; the normal stroma parenchyma ration had gradually normalized. Nine month treatment exhausted the capacity of the stroma for spontaneous recovery and the parenchyma regenerated to a lesser extent. Fibrosis remained practically irreversible 4 months after CC14 administration.
D000818:Animals; D002252:Carbon Tetrachloride Poisoning; D003094:Collagen / Q000032:analysis; D004247:DNA / Q000032:analysis; D005260:Female; D008099:Liver / Q000032:analysis / Q000503:physiopathology; D008106:Liver Cirrhosis, Experimental / Q000139:chemically induced / Q000503:physiopathology*; D008115:Liver Regeneration; D008297:Male; D051381:Rats
D003094:Collagen; D004247:DNA