Induction of esophageal cancer associated with gastric cancer in a dog by N-ethyl-N'-nitro-N-nitrosoguandine.
The experimental induction of gastric cancer was studied in four dogs given oral administration of N-ethyl-N'-nitro-N-nitrosoguanidine (ENNG) in solution. Esophageal cancer with the regional lymph node metastasis was found in one dog at autopsy, with concomitantly existing gastric cancer. This dog, which ingested a total amount of about 38 g of ENNG, died of weakness on the 513th experimental day. Three remaining dogs are still living and under observation.
D000230:Adenocarcinoma / Q000139:chemically induced* / Q000473:pathology; D000818:Animals; D002294:Carcinoma, Squamous Cell / Q000139:chemically induced* / Q000473:pathology; D004285:Dogs; D004938:Esophageal Neoplasms / Q000139:chemically induced* / Q000473:pathology; D004947:Esophagus / Q000473:pathology; D008207:Lymphatic Metastasis; D008297:Male; D009374:Neoplasms, Experimental; D009378:Neoplasms, Multiple Primary / Q000139:chemically induced*; D009604:Nitrosoguanidines; D013270:Stomach / Q000473:pathology; D013274:Stomach Neoplasms / Q000139:chemically induced* / Q000473:pathology
D009604:Nitrosoguanidines