Suppression of heparine-induced increment of rat free fatty acids by oxprenolol.
Injection of heparin i.v. into rats increased significantly free fatty acids (FFAs) plasma levels. When 20 min before the heparin injection 1-(o-allyloxy-phenoxy)-3-isopropylamino-propane-2-ol-hydrochloride (oxprenolol, Trasicor) was administered i.p., FFAs increment was prevented. Isoproterenol-induced plasma FFAs rise was also inhibited by the administration of this beta-adrenergic receptor blocking agent. Treatment by beta-adrenergic receptor blockade for prevention of heparine-induced FFAs increase, which possibly contributes to the appearance of heart arrhythmias, must be considered.
D000818:Animals; D003864:Depression, Chemical; D005230:Fatty Acids, Nonesterified / Q000097:blood*; D005260:Female; D006493:Heparin / Q000494:pharmacology*; D007545:Isoproterenol / Q000494:pharmacology; D008297:Male; D010096:Oxprenolol / Q000494:pharmacology*; D010424:Pentobarbital / Q000494:pharmacology; D051381:Rats
D005230:Fatty Acids, Nonesterified; D010096:Oxprenolol; D006493:Heparin; D010424:Pentobarbital; D007545:Isoproterenol