[The effect of sporofusarin on the cell membranes of isolated perfused liver].
A study was made of the effect of sporofusarin (mycotoxin produced by Fusarium Sporotrichiella v. Sporotrichoides) on the functional activity and permeability of cell membranes of the isolated perfused rat liver. Sporofusarin (in the end concentration of 5.9 . 10(-5) M) produced a marked depressive effect on the rate of bile, formation, urea synthesis and oxygen consumption, and also caused an early and marked disturbance of permeability of the lysosomal and plasma membranes of hepatocytes (an increase in the activity of the enzymes--beta-acetylglucosaminidase, beta-glucuronidase, arylsulfatases A and B, beta-galactosidase in the supernatant fluid of liver homogenate and in the perfusata). It is supposed that depression of the functional activity of the liver under the effect of sporofusarin resulted from damage of the membrane structures of the cell, and, primarily, of lysosomes.
D000118:Acetylglucosaminidase / Q000378:metabolism; D000818:Animals; D001192:Arylsulfatases / Q000378:metabolism; D001646:Bile / Q000378:metabolism; D002463:Cell Membrane Permeability / Q000187:drug effects; D005670:Fusarium / Q000032:analysis; D005696:Galactosidases / Q000378:metabolism; D005959:Glucosidases / Q000378:metabolism; D005966:Glucuronidase / Q000378:metabolism; D008099:Liver / Q000187:drug effects* / Q000201:enzymology / Q000378:metabolism; D008247:Lysosomes / Q000187:drug effects; D008297:Male; D009183:Mycotoxins / Q000302:isolation & purification / Q000494:pharmacology*; D010101:Oxygen Consumption / Q000187:drug effects; D010477:Perfusion; D051381:Rats; D014508:Urea / Q000096:biosynthesis
D009183:Mycotoxins; D014508:Urea; D001192:Arylsulfatases; D005696:Galactosidases; D005959:Glucosidases; D005966:Glucuronidase; D000118:Acetylglucosaminidase
Issledovanie deĭstviia sporofuzarina na kletochnye membrany izolirovannoĭ perfuziruemoĭ pecheni