[Effect of estradiol dipropionate and its combination with insulin on pentosephosphate dehydrogenase cycle activity in the liver and the uterus].
Experimental investigations have shown estradiol-dipropionate and insulin to induce an elevated activity of glucose-6-phosphate- and 6-phospho-gluconate-dehydrogenase in the uterus and the liver. Insulin potentiates the inducing action of estradiol on the pentosophosphate cycle dehydrogenases when both of them are used concurrently. For insulin to display its inducing effect a definite level of endogenous estradiol in the organism is necessary, for insulin fails to exert a specific influence on the study of dehydrogenases in sexually immature and ovariectomized animals.
D000818:Animals; D002369:Castration; D004305:Dose-Response Relationship, Drug; D004347:Drug Interactions; D004789:Enzyme Activation / Q000187:drug effects; D004790:Enzyme Induction / Q000187:drug effects; D004958:Estradiol / Q000494:pharmacology*; D005260:Female; D005954:Glucosephosphate Dehydrogenase / Q000378:metabolism; D007328:Insulin / Q000494:pharmacology*; D008099:Liver / Q000187:drug effects* / Q000201:enzymology; D010053:Ovary / Q000502:physiology; D010088:Oxidoreductases / Q000378:metabolism*; D010428:Pentosephosphates / Q000378:metabolism*; D010734:Phosphogluconate Dehydrogenase / Q000378:metabolism; D051381:Rats; D013268:Stimulation, Chemical; D014599:Uterus / Q000187:drug effects* / Q000201:enzymology
D007328:Insulin; D010428:Pentosephosphates; D004958:Estradiol; D010088:Oxidoreductases; D010734:Phosphogluconate Dehydrogenase; D005954:Glucosephosphate Dehydrogenase
Vliianie éstradiola-dipropionata i ego sochetaniia s insulinom na aktivnost' degidrogenaz pentozobosfatnogo tsikla v pecheni i matke