[Effect of aminazine, tryptazine and droperidol on the uptake and accumulation of exogenous noradrenaline].
Spectrofluorometry, fluorescent histochemistry and cytochemical electron microscopy were employed in studying the capacity of the neuroleptics trifluoroperazine, chlorpromazine and droperidol to bar the capture and accumulation of exogenous norepinephrine (NE) in the tissue, of adrenergic nerve fibers and synaptic vessels of an isolated Vas deferens of the rat. Trifluoroperazine and droperidol were found to be devoid of the property to inhibit the capture and accumulation of NE in the tissue, nerve fibers and in the synaptic vesicles. Chlorpromazine blocked the accumulation of the neurotransmitter, when the mediator was added in a concentration of 1 gamma/ml and failed to produce an inhibitory effect, when NE was used in a greated concentration (30 gamma/ml). It is concluded that all the studied neuroleptics do not hinder the neurotransmitter gaining access into synaptic vesicles, when it is accumulated in the axoplasma.
D000639:Amitriptyline / Q000494:pharmacology*; D000818:Animals; D002746:Chlorpromazine / Q000494:pharmacology*; D003864:Depression, Chemical; D004305:Dose-Response Relationship, Drug; D004329:Droperidol / Q000494:pharmacology*; D004347:Drug Interactions; D006651:Histocytochemistry; D066298:In Vitro Techniques; D008297:Male; D009638:Norepinephrine / Q000378:metabolism*; D051381:Rats; D011941:Receptors, Adrenergic / Q000187:drug effects; D013050:Spectrometry, Fluorescence; D013572:Synaptic Vesicles / Q000187:drug effects / Q000378:metabolism; D013997:Time Factors; D014649:Vas Deferens / Q000187:drug effects
D011941:Receptors, Adrenergic; D000639:Amitriptyline; D004329:Droperidol; D002746:Chlorpromazine; D009638:Norepinephrine
O vliianii aminazina, triftazina i droperidola na zakhvat i nakoplenie ékzogennogo noradrenalina