[The clinical value of the cortisol secretion rate determination in paediatric endocrinology (author's transl)].
The cortisol secretion rate was determined in 18 children according to a modified and simplified method. In 7 cases the determination was repeated after stimulation with synthetic ACTH. 12 of these children suffered from diseases which may affect glucocorticoidsteroid production and the remaining 6 children served as normal controls. In some cases the plasma 11-hydrocorticoid level and urinary excretion of 17-ketogenic steroids were additionally determined. Differences in adrenal function were noted in 2 patients with congenital adrenal hyperplasia (one of the salt-losing type, the other nonsalt-losing type) and 5 patients with adrenal insufficiency. A normal cortisol secretion rate was found in 3 children with diverse disturbances of carbohydrate metabolism, as well as in a child with subtotal adrenalectomy. The clinical value of the determination of the cortisol secretion rate is discussed and was found to be a more reliable indicator of glucocorticoid activity than other parameters.
D015062:11-Hydroxycorticosteroids / Q000097:blood; D015068:17-Ketosteroids / Q000652:urine; D000293:Adolescent; D000302:Adrenal Cortex / Q000187:drug effects; D000304:Adrenal Cortex Function Tests; D000309:Adrenal Insufficiency / Q000097:blood / Q000652:urine; D000315:Adrenalectomy; D000328:Adult; D002648:Child; D003366:Cosyntropin / Q000494:pharmacology; D003922:Diabetes Mellitus, Type 1 / Q000097:blood / Q000652:urine; D005260:Female; D006801:Humans; D006854:Hydrocortisone / Q000378:metabolism*; D012636:Secretory Rate; D013268:Stimulation, Chemical
D015062:11-Hydroxycorticosteroids; D015068:17-Ketosteroids; D003366:Cosyntropin; D006854:Hydrocortisone
Die klinische Bedeutung der Cortisolsekretionsratenbestimmung in der pädiatrischen Endokrinologie