Effect of platinum and palladium salts on thymidine incorporation into DNA of rat tissues.
The intraperitoneal administration of PtCl4 or Pd(NO3)2 at levels of 28 or 56 mumole/kg body weight decreased the thymidine incorporation into DNA of spleen, liver, kidney, and testis. Spleen was most sensitive to both the platinum and the palladium salt. In liver, DNA syntheses in parenchymal cells and stromal cells were about equally sensitive to PtCl4. In control rats, only 20-30% of the 3H in the acid-soluble fraction of liver or spleen was in the form of thymidine and its phosphate esters 2 hr after the intraperitoneal injection of 3H-thymidine; prior injection of PtCl4 (56 mumol/kg body weight) did not change the pattern.
D000818:Animals; D002251:Carbon Tetrachloride / Q000494:pharmacology; D002467:Cell Nucleus / Q000378:metabolism; D004247:DNA / Q000096:biosynthesis*; D007668:Kidney / Q000378:metabolism; D008099:Liver / Q000378:metabolism / Q000648:ultrastructure; D008297:Male; D010165:Palladium / Q000494:pharmacology*; D010984:Platinum / Q000494:pharmacology*; D051381:Rats; D013154:Spleen / Q000378:metabolism; D013737:Testis / Q000378:metabolism; D013936:Thymidine / Q000378:metabolism*
D010984:Platinum; D010165:Palladium; D004247:DNA; D002251:Carbon Tetrachloride; D013936:Thymidine