The binding of dimethylnitrosamine to nucleic acids catalyzed by liver enzymic fractions.
The in vitro binding of a metabolite of dimethylnitrosamine (DMNA) to calf thymus DNA catalyzed by a microsomal system from rat liver is reported. The amount ob binding is unaffected by using microsomes induced by 3-methylcholanthrene and/or normal or induced pH 5 enzymes. The microsomal system is also effective in catalyzing covalent binding of the nitroso compound with synthetic polyribonucleotides.
D000818:Animals; D004247:DNA / Q000378:metabolism*; D004128:Dimethylnitrosamine / Q000378:metabolism*; D066298:In Vitro Techniques; D008862:Microsomes, Liver / Q000378:metabolism*; D009602:Nitrosamines / Q000378:metabolism*; D011131:Polyribonucleotides / Q000378:metabolism; D051381:Rats
D009602:Nitrosamines; D011131:Polyribonucleotides; D004247:DNA; D004128:Dimethylnitrosamine