[The lecithin-sphynogomyelin ratio in the amniotic fluid in insulin dependent diabetic pregnancies].
A delay in the pulmonary maturation of the foetus of diabetic mothers assessed by the lecithin-sphingomyelin (L/S) ratio has been reported (2, 3, 5). A suggestion has been raised that the results of the L/S ratio should be viewed with caution in predicting lung maturity in pregnancies complicated by maternal diabetes (8). We report our findings on 52 insulin-dependent diabetic pregnancies which involved 90 estimations of the L/S ratio on the amniotic fluid. In all cases, the L/S ratio accurately reflected lung maturity, as no hyaline membrane disease (HMD) was observed with a L/S ratio greater than 2. There was no significant difference in the proportion of mature fetal lung between insulin-dependent diabetics and controls for each week of pregnancy between 32 and 38 weeks. There is no statistical difference in the mature L/S ratio between classes B + C and D + F diabetics.
D000653:Amniotic Fluid / Q000032:analysis*; D005260:Female; D005865:Gestational Age; D006801:Humans; D006819:Hyaline Membrane Disease / Q000517:prevention & control*; D007231:Infant, Newborn; D007328:Insulin / Q000627:therapeutic use; D008168:Lung / Q000196:embryology; D010713:Phosphatidylcholines / Q000032:analysis*; D011247:Pregnancy; D011254:Pregnancy in Diabetics / Q000188:drug therapy* / Q000378:metabolism*; D013109:Sphingomyelins / Q000032:analysis*
D007328:Insulin; D010713:Phosphatidylcholines; D013109:Sphingomyelins
Le rapport lécithine-sphingomyéline du liquide amniotique dans les grossesses diabétiques insulino-dépendantes