A chronic study of artificial sweeteners in Syrian golden hamsters.
Chronic administration of saccharin and sodium or calcium cyclamates in drinking water to Syrian golden hamsters, up the maximum tolerated dose level, failed to induce an excess of tumors compared to controls; nor were any urinary bladder tumors found.
D000818:Animals; D002273:Carcinogens; D006224:Cricetinae; D003494:Cyclamates / Q000008:administration & dosage / Q000633:toxicity*; D004334:Drug Administration Schedule; D005260:Female; D008297:Male; D009374:Neoplasms, Experimental / Q000139:chemically induced*; D012439:Saccharin / Q000008:administration & dosage / Q000633:toxicity*; D001749:Urinary Bladder Neoplasms / Q000139:chemically induced*
D002273:Carcinogens; D003494:Cyclamates; D012439:Saccharin