title: Reduction of morphine-withdrawal body shakes by a conditional stimulus in the rat.
abstract: Narcotic dependence in rats was established, in five days, by administering intravenous injections of morphine sulfate in increasing doses. From day six onward, dependence was maintained by administering a morphine injection (15 mg/kg) every 6 h throughout the day, and each of these injections was paired with a tone. After 16 morphine-tone pairings, test trials, in which the tone was presented in the absence of morphine, were instituted. These tone presentations significantly reduced morphine-withdrawal "wet shakes" in rats which received morphine-tone pairings, but not in rats which received control treatments.
mesh_terms: D000161:Acoustic Stimulation; D000818:Animals; D001522:Behavior, Animal; D003216:Conditioning, Operant; D006801:Humans; D008297:Male; D009021:Morphine Dependence / Q000503:physiopathology*; D051381:Rats; D013375:Substance Withdrawal Syndrome / Q000503:physiopathology*