Studies on cardiolipin biosynthesis in Mycobacterium smegmatis.
Supplementation of a growth medium with 5% glucose has been found to stimulate the formation of cardiolipin and phosphatidylethanolamine five- and threefold, respectively, in Mycobacterium smegmatis. The presence of both cytidine diphosphate diglyceride and phosphatidylglycerol pathways of biosynthesis of cardiolipin in cell-free extracts has been demonstrated. The enzymes were localized in the fractions which contained membranes. Isonicotinic acid hydrazide and streptomycin sulfate inhibited the formation of cardiolipin.
D002308:Cardiolipins / Q000096:biosynthesis*; D002474:Cell-Free System; D003567:Cytidine Diphosphate Diglycerides / Q000378:metabolism; D005947:Glucose / Q000378:metabolism; D009161:Mycobacterium / Q000378:metabolism*; D010714:Phosphatidylethanolamines / Q000096:biosynthesis; D010715:Phosphatidylglycerols / Q000378:metabolism; D013307:Streptomycin / Q000494:pharmacology; D013431:Sulfates
D002308:Cardiolipins; D003567:Cytidine Diphosphate Diglycerides; D010714:Phosphatidylethanolamines; D010715:Phosphatidylglycerols; D013431:Sulfates; D005947:Glucose; D013307:Streptomycin