[Experimental xenogenic immune pancreatitis. 1. Histological findings in the mouse exocrine pancreas after treatment with anti-mouse pancreas rabbit serum (author's transl)].
OBJECTIVE
In the pathogenesis of some forms of chronic pancreatitis an immunological influence has been discussed. Therefore, experimental studies of the exocrine pancreas after immunological damage should be done. In this communication histological findings on the mouse exocrine pancreas are presented after treatment with anti-mouse pancreas rabbit serum.


METHODS
a total of 71 adult male white mice was divided into 4 groups treated in the following way: 1. 35 animals with anti-mouse pancreas rabbit serum 2. 14 animals with normal rabbit serum 3. 16 animals with physiological saline 4. 6 animals remained untreated. The sera under study and the saline were, without exception, administered intraperitoneally with single doses of 0.3 ml once, resp. twice daily for 0 up to 16 days. Constantly, 3 hours before sacrifice, the animals received the last injection. For histological examination, the fresh pancreas was fixed in formaline. After embedding in paraffin, sections were stained by the following methods: hematoxyline-eosin, trichrome according to Goldner, Giemsa staining, PAS-reaction, and tryptophane demonstration according to ADAMS (1957).
D000818:Animals; D000906:Antibodies / Q000302:isolation & purification; D000917:Antibody Formation; D007106:Immune Sera; D008297:Male; D051379:Mice; D010195:Pancreatitis / Q000276:immunology* / Q000473:pathology
D000906:Antibodies; D007106:Immune Sera
Experimentelle xenogene Immunakreatitis 1. Histologische Befunde am exokrinen Pankreas der Maus nach Behandlung mit Antimäusepankreas-Kaninchenserum