title: Altered serum gastrin levels in achlorhydric states.
abstract: Hypergastrinemia occurs in achlorhydric states if the antrum is not diseased, and evidence has been presented that suggests that antral gastritis diminishes gastrin levels in achlorhydric patients. There is a dramatic gastrin response to calcium challenge in patients with pernicious anemia. Only minimal response was observed in patients with atrophic gastritis. Unlike the response observed in the Zollinger-Ellison syndrome, secretin challenge suppresses gastrin in achlorhydric states. These findings add a new dimension to the utility of serum gastrin determinations.
mesh_terms: D000126:Achlorhydria / Q000097:blood* / Q000150:complications / Q000473:pathology; D000752:Anemia, Pernicious / Q000097:blood / Q000150:complications; D001284:Atrophy / Q000097:blood / Q000150:complications; D002118:Calcium / Q000008:administration & dosage / Q000494:pharmacology; D005260:Female; D005745:Gastric Acidity Determination; D005750:Gastric Juice / Q000187:drug effects; D005753:Gastric Mucosa / Q000473:pathology; D005755:Gastrins / Q000097:blood*; D005756:Gastritis / Q000097:blood / Q000150:complications; D006801:Humans; D007263:Infusions, Parenteral; D008297:Male; D008875:Middle Aged; D011706:Pyloric Antrum / Q000473:pathology; D012633:Secretin / Q000008:administration & dosage / Q000494:pharmacology
chemical_list: D005755:Gastrins; D012633:Secretin; D002118:Calcium