[Effect of pentoxyfylline on the organ distribution of 47Ca and on intestinal Ca absorption and secretion in the rat (author's transl)].
The influence of 3,7-dimethyl-1-(5-oxo-hexyl)-xanthine (pentoxyfylline, Trental) on organ distribution of 47Ca and on intestinal Ca absorption and secretion was studied in rats. Oral application of 4 mg/kg bodyweight pentoxifylline was followed after 30 min by a significantly higher accumulation of orally applied 47Ca in the intestinal wall as compared to untreated controls, while in other organs the 47Ca activity was lower than in control animals. When 47Ca was given i.p. and pentoxifylline at the same dose was applied orally 24 h later, there was no difference in organ distribution of 47Ca between treated rats and untreated controls after 30 min. There was likewise no difference in serum Ca concentration. On the other hand, i.v. infusion of 20.8 mg/kg bodyweight pentoxifylline was followed by a significant fall of serum Ca. At the same time, there was a significant reduction of intestinal Ca net absorption, as demonstrated by the intestinal perfusion technique, while Ca net secretion was not influenced. The possible mechanisms causing the pentoxifylline induced reduction of serum Ca concentration are discussed.
D000818:Animals; D001842:Bone and Bones / Q000378:metabolism; D002118:Calcium / Q000008:administration & dosage / Q000378:metabolism*; D003864:Depression, Chemical; D007408:Intestinal Absorption / Q000187:drug effects*; D007413:Intestinal Mucosa / Q000378:metabolism; D007668:Kidney / Q000378:metabolism; D008099:Liver / Q000378:metabolism; D008297:Male; D009132:Muscles / Q000378:metabolism; D009206:Myocardium / Q000378:metabolism; D051381:Rats; D013997:Time Factors; D014970:Xanthines / Q000378:metabolism / Q000494:pharmacology*
D014970:Xanthines; D002118:Calcium
Wirkung von Pentoxifyllin auf die Organverteilung von 47Calcium sowie auf die intestinale Calciumabsorption und -sekretion