Potentiated chemotherapeutic activity of 3,6-diamino-10-methyl-acridinium by combination with glycine or DL-alpha-alanine on the Ehrlich carcinoma.
Glycine or DL-alpha-alanine potentiated the chemotherapeutic action of 3,6-diaminoacridinium without increasing its toxicity when these amino acids were combined with it simultaneously. On the contrary, valine in combination with 3,6-diaminoacridinium diminished slightly the chemotherapeutic effect as compared to the monotherapy with 3,6-diaminoacridinium. The monotherapy with the applied amino acids in the same dosage showed no tumor inhibition.
D000166:Acridines / Q000627:therapeutic use*; D000409:Alanine / Q000627:therapeutic use*; D000818:Animals; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D002286:Carcinoma, Ehrlich Tumor / Q000188:drug therapy*; D003520:Cyclophosphamide / Q000627:therapeutic use; D004305:Dose-Response Relationship, Drug; D004357:Drug Synergism; D004359:Drug Therapy, Combination; D005260:Female; D005998:Glycine / Q000627:therapeutic use*; D014633:Valine / Q000627:therapeutic use
D000166:Acridines; D000970:Antineoplastic Agents; D003520:Cyclophosphamide; D014633:Valine; D000409:Alanine; D005998:Glycine