A prospective study of drugs and pregnancy. I. Psychopharmaca.
A prospective study has been performed on the use of psychopharmaca during 6 376 pregnancies and its correlation to certain socio-medical variables and pregnancy outcome. An association between drug use and later miscarriage or legal abortion was demonstrated and is conceivably due to an increased use of such drugs in unwanted pregnancies. No indication of an association between drug use and birth of a dead or defective infant was found. Pregnancies where psychopharmaca were used during the first trimester had, on average, a longer duration than pregnancies where such drugs were not used, but birth weight of full-term infants was not affected.
D000014:Abnormalities, Drug-Induced; D000022:Abortion, Spontaneous / Q000139:chemically induced*; D001724:Birth Weight; D005260:Female; D005313:Fetal Death / Q000139:chemically induced*; D006801:Humans; D007231:Infant, Newborn; D008431:Maternal-Fetal Exchange; D008620:Meprobamate / Q000009:adverse effects; D009497:Neurotic Disorders / Q000188:drug therapy; D011247:Pregnancy; D011261:Pregnancy Trimester, First; D011262:Pregnancy Trimester, Second; D011263:Pregnancy Trimester, Third; D011446:Prospective Studies; D011619:Psychotropic Drugs / Q000009:adverse effects* / Q000627:therapeutic use; D012959:Socioeconomic Factors; D013997:Time Factors
D011619:Psychotropic Drugs; D008620:Meprobamate