[Effect of polyethylene glycols of linear structure and different molecular weights on rat liver lysosomes].
The action of nonionic detergents--polyethyleneglycols of the linear structure with various molecular weight (from 700 to 15 000) on the lysosomes of rat liver was studied. Triton X-100 activated the acid phosphatase of the sum total fraction of lysosomes to a greater degree than the rest of the polyethyleneglycols. The action of polyethyleneglycols on the activation of acid phosphatase in the lysosome subfractions was inconstant. The result obtained is explained from the aspect of the morphological and biochemical heterogeneity of lysosomes. On the basis of comparison of personal data and literature data a supposition is put forward that the resistance of lysosomes to the action of the polyethyleneglycols in vitro and in vivo was the same.
D000135:Acid Phosphatase / Q000378:metabolism; D000818:Animals; D003902:Detergents / Q000494:pharmacology* / Q000627:therapeutic use; D066298:In Vitro Techniques; D008099:Liver / Q000187:drug effects* / Q000201:enzymology; D008247:Lysosomes / Q000187:drug effects* / Q000201:enzymology; D009374:Neoplasms, Experimental / Q000188:drug therapy; D011092:Polyethylene Glycols / Q000494:pharmacology* / Q000627:therapeutic use; D051381:Rats
D003902:Detergents; D011092:Polyethylene Glycols; D000135:Acid Phosphatase
Deĭstvie poliétilenglikoleĭ lineĭnoĭ struktury i razlichnogo molekuliarnogo vesa na lizosomy pecheni krysy