Evidence of donor suppression of anti-donor PFC responses in mice.
Mice receiving high doses of mitomycin C-treated allogeneic spleen donor cells produced more host anti-donor plaque-forming cells than mice receiving high doses of untreated allogeneic spleen donor cells, showing that immunocompetent donor cells capable of recognizing host H-2 antigens can suppress host anti-donor H-2 primary antibody responses. Responses to semi-allogeneic spleen donor cells were consistently lower than responses to allogeneic cells. Low doses of normal allogeneic spleen donor cells showed stimulation of the host anti-donor PFC response compared with similar doses of mitomycin C-treated allogeneic spleen donor cells.
D000818:Animals; D000921:Antibody-Producing Cells / Q000276:immunology*; D006649:Histocompatibility Antigens; D007165:Immunosuppression Therapy; D051379:Mice; D008807:Mice, Inbred BALB C; D008810:Mice, Inbred C57BL; D008937:Mitomycins / Q000494:pharmacology; D013154:Spleen / Q000276:immunology / Q000637:transplantation; D014184:Transplantation, Homologous
D006649:Histocompatibility Antigens; D008937:Mitomycins