The role of membrane parameters and of filtration pressure in the determination of the shape of the polyvinylpyrrolidone sieving curve. An in vitro and in vivo study.
The theoretical equations describing the transport of a solute across a porous membrane predict that the shape of the sieving curve (ratio of solute concentrations in filtrate and filtrand versus molecular size) depends not only on the porosity of the membrane but also on the filtration pressure. This has been verified experimentally on an artificial membrane (Amicon XM-50). This model has been used to interpret the effects of angiotensin II on the shape of the glomerular 125I PVP sieving curve. The mean effective filtration pressure is increased by the intrarenal perfusion of angiotensin II.
D000804:Angiotensin II / Q000494:pharmacology; D000818:Animals; D004285:Dogs; D005374:Filtration; D005919:Glomerular Filtration Rate / Q000187:drug effects; D006973:Hypertension / Q000139:chemically induced / Q000503:physiopathology; D007678:Kidney Glomerulus / Q000502:physiology* / Q000503:physiopathology / Q000648:ultrastructure; D008566:Membranes / Q000502:physiology / Q000503:physiopathology; D008954:Models, Biological; D010539:Permeability; D011205:Povidone; D011312:Pressure
D000804:Angiotensin II; D011205:Povidone