Haemodynamic changes associated with CCl4-induced acute liver injury.
Minor doses of CCl4 have been found to produce acute haemodynamic changes which promote elimination of the poison from the body. Major doses absorbed into the blood are followed by a transitory fall of perfusion pressure resulting in a deficient oxygenation of the tissues. The released mechanisms of adjustment result in general haemodynamic changes directed at the maintenance of blood flow in the vital organs, primarily in the brain. Accumulation of CCl4 is associated with prolonged haemodynamic alterations: the cardiac output and tissue flow decreases while peripheral resistance increases. The reduction in blood flow was most marked in the liver. The transitory and prolonged haemodynamic changes result in an impairment of hepatocellular nutrition and oxygenation, thus precipitating the injury caused by the CCl4 accumulated in the liver cells.
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D002252:Carbon Tetrachloride Poisoning / Q000503:physiopathology*; D002496:Central Venous Pressure / Q000187:drug effects; D056486:Chemical and Drug Induced Liver Injury; D004285:Dogs; D005260:Female; D006439:Hemodynamics / Q000187:drug effects*; D008107:Liver Diseases / Q000503:physiopathology; D008297:Male; D011674:Pulse / Q000187:drug effects; D012039:Regional Blood Flow / Q000187:drug effects; D012119:Respiration / Q000187:drug effects; D014655:Vascular Resistance / Q000187:drug effects