[Intracellular mechanism of the action of imipramine and diazepam].
The content of noradrenaline during the action of antidepressant imipramine and a tranquilizer diazepam was determined in rats by differential centrifugation of the hypothalamus tissues. Imipramine was found to decrease the noradrenaline content in synaptosomes, whereas diazepam failed to evoke any similar effects. Thus, in the action mechanism of the first substance the adrenergic compound was of definite importance, while in the mechanism of the second one it took no part.
D000818:Animals; D003975:Diazepam / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D007031:Hypothalamus / Q000166:cytology; D007099:Imipramine / Q000494:pharmacology*; D008928:Mitochondria / Q000187:drug effects; D009186:Myelin Sheath / Q000187:drug effects; D009638:Norepinephrine / Q000378:metabolism; D011506:Proteins / Q000378:metabolism; D051381:Rats; D013347:Subcellular Fractions / Q000187:drug effects* / Q000378:metabolism; D013574:Synaptosomes / Q000187:drug effects
D011506:Proteins; D007099:Imipramine; D003975:Diazepam; D009638:Norepinephrine
O vnutrikletochnom mekhanizme deĭstviia imipramina i diazepama