title: [The effect of various solvents (benzene, toluene, acetone) used with carcinogens on the collagen content of the mouse dorsal skin].
abstract: Benzene, toluene and acetone--frequently used as solvents of skin carcinogens--have different effects on the skin collagen of mice: Benzene and toluene lower the collagen content significantly whereas acetone does not. Methylcholanthrene solved in acetone causes a slower collagen decrease and a longer latency period of tumor development as can be observed, when solved in benzene or toluene. This leads to the conclusion, that benzene and toluene have a cocarcinogenic potency.
mesh_terms: D000096:Acetone / Q000494:pharmacology; D000818:Animals; D001554:Benzene / Q000494:pharmacology; D002273:Carcinogens; D003094:Collagen / Q000032:analysis*; D005260:Female; D006909:Hydroxyproline / Q000032:analysis; D051379:Mice; D012867:Skin / Q000032:analysis / Q000187:drug effects*; D012997:Solvents / Q000494:pharmacology*; D014050:Toluene / Q000494:pharmacology
chemical_list: D002273:Carcinogens; D012997:Solvents; D000096:Acetone; D014050:Toluene; D003094:Collagen; D001554:Benzene; D006909:Hydroxyproline
vernacular_title: Uber die Wirkung einiger für Karzinogene verwendete Lösungsmittel (Benzol, Toluol, Aceton) auf den Kollagengehalt der Rückenhaut von Mäusen