[Effect of phentolamine and anaprilin on the makeup and distribution of electrolytes in the myocardium].
Acute tests with rats demonstrated that the adrenoblocking agent phentolamine acts predominantly on the potassium level in the myocardium, raising its total, intra- and extra-cellular content. The effect of anapriline was mainly on sodium. Thyramine, which like adrenoblocking agents displays a catecholine-reducing effect, did not produce any similar changes in the potassium and sodium content.
D000818:Animals; D004347:Drug Interactions; D004573:Electrolytes / Q000378:metabolism*; D005260:Female; D006321:Heart / Q000187:drug effects*; D008297:Male; D009206:Myocardium / Q000378:metabolism*; D010646:Phentolamine / Q000494:pharmacology*; D011188:Potassium / Q000378:metabolism; D011433:Propranolol / Q000494:pharmacology*; D051381:Rats; D012964:Sodium / Q000378:metabolism; D013997:Time Factors; D014439:Tyramine / Q000494:pharmacology
D004573:Electrolytes; D012964:Sodium; D011433:Propranolol; D011188:Potassium; D014439:Tyramine; D010646:Phentolamine
Vliianie fentolamina i anaprilina na sostav i raspredelenie élektrolitov v miokarde