The suppressing effect of indomethacin on articular cartilage.
Indomethacin in pharmacological doses was given to rabbits with papain-induced degenerative arthrosis of the knee. The cartilage lesions healed between the 35th and the 70th day of the experiment. The healing was unaffected by indomethacin. However, autoradiographs showed a significantly reduced 35SO4 uptake in the articular cartilage of the animals receiving the indomethacin in both arthritic and control knees.
D000818:Animals; D001345:Autoradiography; D002358:Cartilage, Articular / Q000187:drug effects* / Q000378:metabolism; D007213:Indomethacin / Q000494:pharmacology*; D007592:Joint Diseases / Q000139:chemically induced* / Q000378:metabolism; D007719:Knee Joint / Q000378:metabolism; D008297:Male; D010206:Papain; D011817:Rabbits; D013431:Sulfates / Q000378:metabolism
D013431:Sulfates; D010206:Papain; D007213:Indomethacin