The effects of CBG on the in vitro reduction of 3H-progesterone by liver homogenates and cell suspensions.
The effects of CBG on 3H-progesterone metabolism by ovine, bovine and rat liver homogenates and bovine and rat liver cell suspensions were studied. As a source of CBG served plasma from "estrogenized" women. Same plasma, pretreated at 60 degree for 20 min. served as control. It was found that the amounts of 3H-progesterone remaining after incubation were higher in the presence of CBG, as compared with control incubations, when using the homogenates. No such effect was observed in case of cell suspensions.
D000818:Animals; D002417:Cattle; D005260:Female; D006801:Humans; D008099:Liver / Q000166:cytology / Q000378:metabolism*; D011374:Progesterone / Q000378:metabolism*; D011485:Protein Binding; D051381:Rats; D012756:Sheep; D014156:Transcortin / Q000494:pharmacology*
D011374:Progesterone; D014156:Transcortin