Histology of chemically induced mesotheliomas in MRC-Wistar rats.
Two peritoneal mesotheliomas were induced in rats during a carcinogenicity study of 1-nitroso-5,6-dihydrouracil (NO-DHU) injected intraperitoneally. A review of literature concerning experimental induction of such tumors indicated that they seldom produced with organic compounds and rarely occur spontaneously. In the present study, several reports of chemically induced mesotheliomas of the testes are analyzed and the diagnoses critically reviewed along with other differential diagnoses.
D000818:Animals; D002273:Carcinogens; D008297:Male; D008654:Mesothelioma / Q000139:chemically induced*; D009374:Neoplasms, Experimental / Q000139:chemically induced; D009602:Nitrosamines; D009603:Nitroso Compounds; D010534:Peritoneal Neoplasms / Q000139:chemically induced*; D051381:Rats; D014498:Uracil / Q000031:analogs & derivatives*
D002273:Carcinogens; D009602:Nitrosamines; D009603:Nitroso Compounds; C011954:1-nitroso-5,6-dihydrouracil; D014498:Uracil