title: Modification of the epidermal growth factor affecting the stability of its high molecular weight complex.
abstract: The epidermal growth factor (EGF) can be isolated from the submaxillary gland of the adult male mouse as part of a high molecular weight complex (HMW-EGF). This complex can be reversibly dissociated into its subunits, EGF AND EGF-binding protein, an arginine esteropeptidase (Taylor, J. M., Cohen, S., and Mitchell, W. M. (1970) Proc. Natl. Acad. Sci. U. S. A. 67, 164-171). The COOH-terminal arginine residue of EGF was quantitatively removed by digestion with carboxypeptidase B...
mesh_terms: D000596:Amino Acids / Q000032:analysis; D000818:Animals; D001665:Binding Sites; D006133:Growth Substances / Q000378:metabolism / Q000494:pharmacology; D007700:Kinetics; D046911:Macromolecular Substances; D008297:Male; D051379:Mice; D008970:Molecular Weight; D010447:Peptide Hydrolases; D010455:Peptides / Q000494:pharmacology; D011485:Protein Binding; D012867:Skin / Q000187:drug effects; D013363:Submandibular Gland / Q000032:analysis
chemical_list: D000596:Amino Acids; D006133:Growth Substances; D046911:Macromolecular Substances; D010455:Peptides; D010447:Peptide Hydrolases