Different inhibitory effect of nitrogen mustard (HN2) and TS-160 (HN3) on choline transport in L 5178Y lymphoblasts.
The inhibitory effect of the alkylating agents nitrogen mustard (HN2) and TS-160 (HN3) on the choline transport in L 5178Y lymphoblasts was studied. The two alkylating agents differed in the degree and in the nature of the inhibition of the process examined. Competitive inhibition of choline transport by HN2 was confirmed, whereas the noncompetitive inhibition by the less efficient inhibitor HN3 has been found. The results achieved indicate that in spite of the structural similarity between HN2 and HN3 only the former is transported into L 5178Y lymphoblasts by the choline transport carrier.
D000477:Alkylating Agents / Q000494:pharmacology*; D000588:Amines / Q000494:pharmacology*; D000818:Animals; D001667:Binding, Competitive; D001692:Biological Transport / Q000187:drug effects; D002794:Choline / Q000378:metabolism*; D007942:Leukemia, Experimental / Q000378:metabolism*; D008466:Mechlorethamine / Q000494:pharmacology*; D009588:Nitrogen Mustard Compounds / Q000494:pharmacology*
D000477:Alkylating Agents; D000588:Amines; D009588:Nitrogen Mustard Compounds; D008466:Mechlorethamine; C009802:2,2',2''-trichlorotriethylamine; D002794:Choline