[Studies on placental blood flow under drug induced hypertension (animal experiments) (author's transl)].
Placental blood-flow rates in rabbits were measured by the indirect method of local apparent conductivity. In our experiments, hypertension was produced by injection or infusion of hypertensive drugs. As a result of hypertension we observed a marked decrease in placental blood flow. Vasoconstriction seems to be the pathophysiologic mechanism causing the reduced blood flow rate. Accordingly, the placenta may not be considered as a "priviledged organ" in circulatory regulations. In our experiments, placental ischemia subsequently to ligatures did not produce hypertension so that the production of a placental pressor-substance could not be demonstrated. If we assume a circulus vitiosus hypertension-placental ischemia-hypertension, the hypertension seems to be the primary cause.
D000804:Angiotensin II; D000818:Animals; D001794:Blood Pressure; D004837:Epinephrine; D005260:Female; D006973:Hypertension / Q000139:chemically induced / Q000503:physiopathology*; D007511:Ischemia; D010920:Placenta / Q000098:blood supply*; D011247:Pregnancy; D011817:Rabbits; D012039:Regional Blood Flow; D013997:Time Factors
D000804:Angiotensin II; D004837:Epinephrine
Das Verhalten der Plazentadurchblutung unter medikamentös erzeugter Hypertonie im Tierversuch