[Reduction of serum triglycerides with a combined application of butylbiguanide and clofibrate in animal experiments].
When given separately, neither butylbiguanide (N1-butylbiguanide-hydrochloride, the active principle of Silubin retard) (75 mg/kg) nor clofibrate (30 mg/kg) decreased the serum triglycerides in normolipaemic rats. In combined administration, however, the two drugs produced a statistically significant average decrease in serum triglycerides by 30%. Simultaneous administration of the two drugs also lowered triglycerides in rats with carbohydrate-induced hypertriglyceridaemia.
D000818:Animals; D001645:Biguanides / Q000494:pharmacology*; D002026:Buformin / Q000494:pharmacology*; D002994:Clofibrate / Q000494:pharmacology*; D003864:Depression, Chemical; D004347:Drug Interactions; D005632:Fructose / Q000097:blood; D006949:Hyperlipidemias / Q000097:blood; D008297:Male; D051381:Rats; D014280:Triglycerides / Q000097:blood*
D001645:Biguanides; D014280:Triglycerides; D005632:Fructose; D002994:Clofibrate; D002026:Buformin
Senkung der Serumtriglyzeride durch kombinierte Gabe von Butylbiguanid und Clofibrat im Tierexperiment