[Influence of vitamins C, Bl, and B6 on the diurnal periodicity of the glucocorticoid function of the adrenal cortex in patients with atherosclerotic cardiosclerosis].
Diurnal periodicity of the glucocorticoid function of the adrenal cortex was studied in 52 patients with atherosclerotic cardiosclerosis without and with circulatory insufficency of the I, IIA and IIB stage, based on the determination of 17-OCS in 3 portions of the urine collected at equal 8-hours long time intervals. The patients without circulatory insufficiency and with insufficiency of the 1st stage received ascorbic acid in amounts of 0.3 g thrice a day, along with vitamins B1 and B6 (5 and 6 per cent) in doses of 1 ml for 14-16 days. Patients with circulatory insufficiency of the IIA and IIB stages were given vitamins and cardiac glycosides. Investigations ascertained disturbed rhythmic and functional activity of the suprarenals in these patients. The treatment resulted in improving the glucocorticoid function of the adrenal cortex with simultaneous normalization of the rhythmic activity of the suprarenals.
D015065:17-Hydroxycorticosteroids / Q000652:urine; D000302:Adrenal Cortex / Q000187:drug effects* / Q000503:physiopathology*; D000311:Adrenal Glands / Q000187:drug effects* / Q000503:physiopathology*; D000328:Adult; D000368:Aged; D001205:Ascorbic Acid / Q000494:pharmacology*; D002940:Circadian Rhythm / Q000187:drug effects*; D003327:Coronary Disease / Q000503:physiopathology*; D006801:Humans; D008875:Middle Aged; D011736:Pyridoxine / Q000494:pharmacology*; D013831:Thiamine / Q000494:pharmacology*
D015065:17-Hydroxycorticosteroids; D011736:Pyridoxine; D001205:Ascorbic Acid; D013831:Thiamine
Vliianie vitaminov C, Bl, i B6 na sutochnuiu periodichnost' gliukokortikoidnoĭ funktsii kory nadpochechnikov u bol'nykh ateroskleroticheskim kardiosklerozom