Cerebrospinal fluid levels of chlorpromazine and it metabolites in schizophrenia.
The concentrations of chlorpromazine and some of its metabolites in blood plasma and CSF from chlorpromazine-treated schizophrenics with different therapeutic results were studied. Compared to a good responder a poor responder showed very high levels of the inactive metabolite chlorpromazine sulphoxide in the CSF.
D000328:Adult; D002746:Chlorpromazine / Q000097:blood / Q000134:cerebrospinal fluid* / Q000378:metabolism; D005260:Female; D006801:Humans; D008297:Male; D012559:Schizophrenia / Q000134:cerebrospinal fluid / Q000188:drug therapy*
D002746:Chlorpromazine