Enhanced inhibition of RNA synthesis by amanitins in in vitro cultured cells.
The inhibition of RNA synthesis by alpha-amanitin on in vitro cultured cells is very slow. The action of various analogueoreover pretreatment of cell cultures with DEAE-dextran greatly enhanced the effect of beta-amanitin.
D000546:Amanitins / Q000494:pharmacology*; D000666:Amphotericin B / Q000494:pharmacology; D002460:Cell Line; D003637:DEAE-Dextran / Q000494:pharmacology; D066298:In Vitro Techniques; D012313:RNA / Q000096:biosynthesis*; D014529:Uridine / Q000378:metabolism
D000546:Amanitins; D012313:RNA; D000666:Amphotericin B; D003637:DEAE-Dextran; D014529:Uridine