[Biological and physicochemical properties of the alpha- and beta-forms of cephaloridine].
Alfa- and delta forms of cephalosporin were compared. Biological activity, lantimicrobial spectrum and innocuousness of the forms and their physico-chemical properties were investigated with the methods of infrared and ultraviolet spectrophotometry and derivatography. No significant differences in the biological properties of alfa- and delta forms of cephalosporin were found. However, the ingrared spectrum of the delta-form was indicative of higher stability of its molecule, which was confirmed by higher thermostability of delta-cephalosporin.
D000818:Animals; D002509:Cephaloridine / Q000032:analysis / Q000494:pharmacology* / Q000633:toxicity; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D002642:Chick Embryo; D002854:Chromatography, Paper; D004355:Drug Stability; D051379:Mice; D013056:Spectrophotometry, Ultraviolet; D013211:Staphylococcus aureus / Q000187:drug effects; D013696:Temperature
D002509:Cephaloridine
Biologicheskie i fizilo-khimicheskie svoĭstva al'fa- i betaform tsefaloridina