The rifamycin derivative AF/013 is cytolytic.
D000818:Animals; D000903:Antibiotics, Antineoplastic; D002463:Cell Membrane Permeability / Q000187:drug effects; D002645:Chickens; D012321:DNA-Directed RNA Polymerases / Q000378:metabolism; D004912:Erythrocytes / Q000187:drug effects* / Q000378:metabolism / Q000648:ultrastructure; D005347:Fibroblasts / Q000187:drug effects* / Q000378:metabolism / Q000648:ultrastructure; D006367:HeLa Cells / Q000187:drug effects* / Q000378:metabolism / Q000648:ultrastructure; D006801:Humans; D051379:Mice; D012294:Rifamycins / Q000494:pharmacology*; D014529:Uridine / Q000378:metabolism
D000903:Antibiotics, Antineoplastic; D012294:Rifamycins; D012321:DNA-Directed RNA Polymerases; D014529:Uridine