[Clinical morphological picture of the mucosa of the middle ear in experimental chronic otitis media in rabbits treated with combined antibiotic aerosol preparations].
An new method of treating chronic purulent middle otitis with combined aerosol drugs (oxycyclosol, polysol, levovinylsol, vinysol) was developed at the USSR Research Institute on Antibiotics and tested experimentally on 20 Shinshilla rabbits. A 0.3 ml volume of microbial suspensition: Staphylococcus (group I), Ps. aeruginosa (group II), Proteus vulgaris (group III) and mixed microbial flora (group IV) were administered into the cavities of the middle ear of the rabbits from both sides. The acute process was made chronic by using decreased daily food ration and repeated putting of the rabbit extremeties into cool water. After that the rabbits were subjected to treatment with the above drugs for a week. Damages in the drum cavity mucosa with dystrophy, necrosis and cell separation were observed in the control (not treated) animals. Analogous changes were found also in the auditory tube. Signs of necrosis followed by decomposition were detected in the bone tissue. Only some thickening of the mucosa and bone wall of the drum cavity in the ears and single lymphoid and plasmic cells were recorded in the rabbits subjected to the treatment with the aerosol drugs.
D000336:Aerosols; D000818:Animals; D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D002908:Chronic Disease; D004338:Drug Combinations; D004432:Ear, Middle / Q000382:microbiology / Q000473:pathology*; D009092:Mucous Membrane / Q000382:microbiology / Q000473:pathology; D010033:Otitis Media / Q000188:drug therapy / Q000382:microbiology / Q000473:pathology*; D011817:Rabbits; D013203:Staphylococcal Infections / Q000188:drug therapy / Q000382:microbiology; D013701:Temporal Bone / Q000473:pathology; D013997:Time Factors
D000336:Aerosols; D000900:Anti-Bacterial Agents; D004338:Drug Combinations
Kliniko-morfologicheskaia kartina slizistoĭ obolochki srednego ukha pri éksperimental'nom khronicheskom srednem otite u krolikov, lechennykh kombinirovannymi aérozol'nymi preparatami antibiotikov