Effect of cold isotonic glucose infusion on A-V nodal conduction.
His bundle electrograms were performed in eight patients with organic heart disease. Recordings were made at various rates utilizing right atrial pacing. A solution of 100 cc of iced cold 5% glucose and water was infused through a cardiac catheter placed at the level of the tricuspid valve. The P-A, A-H, H-Q and H-S intervals were determined before and immediately after the cold water infusion. A significant prolongation of the A-H interval occurred with negligible effects on the P-A, H-Q and H-S intervals. At the atrial pacing rate of 100/min the average A-H interval increased from the control value of 116 to 125 msec after the infusion (P less than 0.02); at the pacing rate of 140/min, the A-H interval increased from 147 to 158 msec (P less than 0.01). This represents an impairment in conduction through the atrioventricular node.
D000200:Action Potentials; D000293:Adolescent; D000328:Adult; D000368:Aged; D001283:Atrioventricular Node / Q000187:drug effects* / Q000503:physiopathology; D002036:Bundle of His / Q000503:physiopathology; D006328:Cardiac Catheterization / Q000379:methods; D004562:Electrocardiography; D005260:Female; D005947:Glucose / Q000008:administration & dosage / Q000494:pharmacology*; D006329:Heart Conduction System / Q000187:drug effects*; D006331:Heart Diseases / Q000503:physiopathology; D006801:Humans; D007036:Hypothermia, Induced / Q000009:adverse effects*; D007552:Isotonic Solutions; D008297:Male; D008875:Middle Aged; D009431:Neural Conduction / Q000187:drug effects; D010138:Pacemaker, Artificial; D012849:Sinoatrial Node / Q000503:physiopathology
D007552:Isotonic Solutions; D005947:Glucose