[The effect of strophanthin following administration of homocardiac antigen to animals with experimental myocardial infarct].
A study was made of strophanthin sensitivity and hemodynamic effect of glycosidein immunization of rabbits with a homocardiac antigen on the 1st, 3rd and 5th days after the reproduction of myocardial infarction. The titre of anticardiac autoantibodies proved to decrease on the 10th day after the ligation of the coronary artery, and also there was a sharp reduction of strophanthin sensitivity by the values of the minimal lethal dose and the toxic one (causing cardiac arrhthmia). Changes in strophanthin tolerance under conditions of administration of the antigen from the myocardium with infarction are associated with the intensive immunopathological shifts in the heart.
D000818:Animals; D001327:Autoimmune Diseases / Q000150:complications* / Q000503:physiopathology; D002682:Chinchilla; D006321:Heart / Q000503:physiopathology; D006439:Hemodynamics; D009203:Myocardial Infarction / Q000150:complications* / Q000503:physiopathology; D009206:Myocardium / Q000276:immunology*; D011817:Rabbits; D013328:Strophanthins
D013328:Strophanthins
Osobennosti deĭstviia strofantina pri vvedenii gomokardial'nogo antigena zhivotnym s éksperimental'nym enfarktom miokarda