title: Antileukemic principles isolated from euphorbiaceae plants.
abstract: Extracts of Euphorbia esula L. and Croton tiglium L., two members of the Euphorbiaceae which have been used widely in folk medicine for treating cancers, showed antileukemic activity against the P-388 lymphocytic leukemia in mice. Systematic fractionation of the extract of Euphorbia esula L. led to characterization of a major antileukemic component as the new diterpenoid diester, ingenol 3,20-dibenzoate. Similar fractionation of Croton oil led to characterization of phorbol 12-tiglate 13-decanoate as an active principle.
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000302:isolation & purification; D001565:Benzoates; D003436:Croton Oil / Q000032:analysis; D004224:Diterpenes / Q000302:isolation & purification / Q000627:therapeutic use*; D007942:Leukemia, Experimental / Q000188:drug therapy*; D051379:Mice; D010703:Phorbol Esters / Q000302:isolation & purification / Q000627:therapeutic use*; D010704:Phorbols / Q000627:therapeutic use*; D010946:Plants, Medicinal / Q000032:analysis*
chemical_list: D000970:Antineoplastic Agents; D001565:Benzoates; D004224:Diterpenes; D010703:Phorbol Esters; D010704:Phorbols; C011986:phorbol 12-tiglate 13-decanoate; D003436:Croton Oil