title: Crossover effects in experimental investigations with human subjects.
abstract: Simple crossover studies with drugs may introduce artifactual results. Volunteers are frequently less apprehensive when tested on the second occasion and experimental medication may result in different performance measures. Empirical evidence is given to demonstrate this point and a suggestion is made as to how it can be overcome.
mesh_terms: D000704:Analysis of Variance; D004644:Emotions; D006801:Humans; D008297:Male; D009048:Motor Skills / Q000187:drug effects; D011584:Psychology; D011619:Psychotropic Drugs / Q000494:pharmacology*; D012107:Research Design; D011795:Surveys and Questionnaires
chemical_list: D011619:Psychotropic Drugs