Treatment of diabetes insipidus with 1-deamino-8-d-arginine vasopressin.
The effect on water metabolism of 1-deamino-8-D-arginine vasopressin and lysine vasopressin have been studied and compared in 20 vasopressin-sensitive and 2 ADH-resistant diabetes insipidus patients. In every case of ADH-sensitive diabetes insipidus, diuresis decreased and the urinary osmolality increased more markedly and for a longer time with the former than with the latter drug. Both drugs were ineffective in patients with ADH-resistant diabetes insipidus. Administration of 1-deamino-8-D-arginine vasopressin did not cause any side effect. It is concluded that 1-deamino-8-D-arginine vasopressin can successfully be employed in the treatment of ADH-sensitive diabetes insipidus.
D000281:Administration, Intranasal; D000293:Adolescent; D000328:Adult; D055598:Chemical Phenomena; D002621:Chemistry; D003894:Deamino Arginine Vasopressin / Q000008:administration & dosage / Q000627:therapeutic use*; D003919:Diabetes Insipidus / Q000188:drug therapy* / Q000209:etiology; D004231:Diuresis / Q000187:drug effects; D005260:Female; D006801:Humans; D007275:Injections, Intravenous; D008236:Lypressin / Q000008:administration & dosage / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged; D009994:Osmolar Concentration; D013997:Time Factors; D014667:Vasopressins / Q000031:analogs & derivatives*
D014667:Vasopressins; D008236:Lypressin; D003894:Deamino Arginine Vasopressin