title: [Effects of the cobalt ion on the in vitro growth of mouse fetus fibroblasts (author's transl)].
abstract: The effect of cobalt II (CoCl2.6 H2O) on growth and plating efficiency of an established line of BALB/c mouse embryo cells was examined. The degree of inhibition of cell proliferation was dependent on both cobaltous ion dose and duration of treatment. Plating efficiency was enhanced by low doses and/or short time of exposure, but was reduced by treatment with higher doses or of longer duration.
mesh_terms: D000818:Animals; D002455:Cell Division / Q000187:drug effects; D002471:Cell Transformation, Neoplastic / Q000187:drug effects; D003035:Cobalt / Q000494:pharmacology*; D005260:Female; D005333:Fetus; D005347:Fibroblasts / Q000187:drug effects / Q000254:growth & development*; D051379:Mice; D008807:Mice, Inbred BALB C; D011247:Pregnancy; D013997:Time Factors
chemical_list: D003035:Cobalt
vernacular_title: Effetti dello ione cobalto sulla crescita in vitro di fibroblasti di feti di topo