[Comparative evaluation of the immunological activity of new typhoid vaccines with established prophylactic effectiveness (data from a controlled experiment)].
The authors present the results of studying the immunological efficacy of a dry alcoholic typhoid vaccine enriched with S. typhi Vi-antigen in the assessment of this vaccine in controlled epidemiological trial during the immunization of children aged 7--8 years. O- and Vi-antibodies were tested in the reaction of hemagglutination, H-antibodies--in the agglutination reaction with the microbial diagnostic agent, the properties of antibodies--in a test with cystein, and bactericidal properties of the sera--against the virulent S. typhi strain. Examination of 355 coupled sera obtained before and 3 weeks after the immunization demonstrated a high level of Vi-(1:47) and of the O-(1:580) antibodies and high bactericidal properties of the sera in persons vaccinated with the alcoholic vaccine enriched with the S. typhi Vi-antigen. The results obtained and the data on the formation of prolonged immunity following a simgle immunization suggested that a high protective effect was caused by a combined action of the O- and Vi-antigens contained in the vaccine in optimal doses.
D000372:Agglutination Tests; D000907:Antibodies, Bacterial / Q000032:analysis; D000942:Antigens, Bacterial / Q000008:administration & dosage; D001770:Blood Bactericidal Activity / Q000187:drug effects; D002648:Child; D003545:Cysteine; D006386:Hemagglutination Tests; D006801:Humans; D007109:Immunity; D007114:Immunization; D012485:Salmonella typhi / Q000276:immunology; D013745:Tetanus Toxoid / Q000494:pharmacology; D013997:Time Factors; D014436:Typhoid-Paratyphoid Vaccines / Q000494:pharmacology*
D000907:Antibodies, Bacterial; D000942:Antigens, Bacterial; D013745:Tetanus Toxoid; D014436:Typhoid-Paratyphoid Vaccines; D003545:Cysteine
Sravnitel'naia otsenka immunologicheskoĭ aktivnosti novykh briushnotifoznykh vaktsin s ustanovlennoĭ profilakticheskoĭ éffektivnost'iu (dannye kontroliruemogo opyta)