The possible mode of action of prostaglandins IX-prostaglandin F2alpha involvement in the reversal of ovulation blockade by ergocornine in rats.
A single injection of 1 mg ergocornine methanesulphonate to semispayed rat on day 3 of the cycle was found to block ovulation. However, the animals showed regular compensatory hypertrophy of the remaining ovary. Prostaglandin F2alpha (PGF2alpha) of 2.0 mg/kg bw on days 3 and 4 in the ergocornine-blocked semispayed rats consistently reversed the blocking effect and the animals showed compensatory ovulation and ovarian hypertrophy. It was moreover observed that the ergocornine-treated mated animals did not become either pregnant or pseudopregnant, but returned to normal cycle as usual. Conversely, the animals which had combined regimen of ergocornine and PGF2alpha became pregnant and the number of embryonic swellings in a single horn and their average weight were statistically identical to their experimental controls. The possible involvement of PGF2alpha in the mechanism of follicular rupture has been discussed.
D000818:Animals; D004357:Drug Synergism; D004873:Ergolines / Q000494:pharmacology*; D005260:Female; D009929:Organ Size; D010053:Ovary / Q000187:drug effects / Q000502:physiology*; D010060:Ovulation / Q000187:drug effects*; D010063:Ovum; D011247:Pregnancy; D011460:Prostaglandins F / Q000494:pharmacology*; D051381:Rats
D004873:Ergolines; D011460:Prostaglandins F