A developmental study of the effects of 5,7-dihydroxytryptamine on regional tryptophan hydroxylase in rat brain.
Tryptophan hydroxylase activity rises rapidly after birth in 5 distinct regions of the rat CNS. Near-adult levels of activity are recorded by 22 days of age in the cell-body rich regions of the brainstem and by 42 days in the terminal-rich areas, hypothalamus and remaining forebrain. The intracisternal injection of 40 mug 5,7-dihydroxytryptamine on day 2 after birth results in a near-total depletion of tryptophan hydroxylase in all CNS regions analyzed 6 or 12 days after drug administration. Enzyme activity recovers (to 11-24% of age matched controls) between day 12 and 20 after 5,7-dihydroxytryptamine in hypothalamus, midbrain and pons medulla oblongata. The growth of 5,7-DHT-treated animals is retarded between 3 and 40 days after drug administration.
D000367:Age Factors; D000818:Animals; D001835:Body Weight / Q000187:drug effects; D001921:Brain / Q000187:drug effects / Q000201:enzymology*; D005260:Female; D006128:Growth / Q000187:drug effects; D008297:Male; D006899:Mixed Function Oxygenases / Q000378:metabolism*; D009474:Neurons / Q000502:physiology; D011247:Pregnancy; D051381:Rats; D012701:Serotonin / Q000494:pharmacology* / Q000502:physiology; D014365:Tryptophan Hydroxylase / Q000037:antagonists & inhibitors / Q000378:metabolism*
D012701:Serotonin; D006899:Mixed Function Oxygenases; D014365:Tryptophan Hydroxylase