[Content of immunoreactive insulin and catecholamines in blood plasma and disorders of carbohydrate metabolism in patients with myocardial infarct].
The blood plasma level of immunoreactive insulin was studied dynamically be means of radioimmunoassay and the blood sugar level by the orthotoluidine technique in 70 patients with large-focal myocardial. In 48 of them the plasma level of catecholamines was determined simultaneously by the fluorimetric technique. The control group of patients was composed of ischaemic heart disease cases without myocardial infarction. Patients with acute myocardial infarction appeared to have hypercatecholaminemia and insufficient insulin excretion: 65.4% of acute myocardial infarction patients having an absolute insulin insufficiency, and 34.6% -- a relative one. The most distinct hypercatecholaminemia and insulin secretion inhibition were observed in those with acute myocardial infarction and congestive heart failure. In patients with an absolute insulin insufficiency the plasma level of noradrenaline was considerably and statistically significantly higher, than in those with a relative insulin insufficiency. In patients with high hypercatecholaminemia the insulin secretion inhibition was noted more often and was more severe. In patients with acute myocardial infarction and an absolute insulin insufficiency complications, such as congestive heart failure and rhythm and conductivity disorders, were more frequent and lasting, than in those with a relative insulin insufficiency. During the acute period of myocardial infarction the disorders in the carbohydrate metabolism were observed in 82.2% of the cases, and were more distinct in those with an absolute insulin insufficiency. By the 20th--22nd postinfarction day the carbohydate metabolism disorders persisted in 35% of the myocardial infarction patients.
D000328:Adult; D000368:Aged; D000941:Antigens; D001786:Blood Glucose / Q000032:analysis*; D002395:Catecholamines / Q000097:blood*; D005260:Female; D006801:Humans; D006943:Hyperglycemia / Q000209:etiology; D007328:Insulin / Q000097:blood / Q000172:deficiency / Q000276:immunology*; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000097:blood* / Q000150:complications
D000941:Antigens; D001786:Blood Glucose; D002395:Catecholamines; D007328:Insulin
Soderzhanie immunoreaktivnogo insulina, katekholaminov v plazme krovi i narusheniia uglevodnogo obmena u bol'nykh infarktom miokarda