title: [Endolumbar administration of hydrocortisone in the complex treatment of patients with generalized breast cancer].
abstract: An efficacy of the method of hormonal therapy--endolumbar hydrocortisone injection in patients with advanced breast cancer has been studied. A remission was gained in 28 of 41 patients. The method proved to be mostly effective in metastases in bones. Changes in the level of estrogens, 17-KS and 17-OCS excretion with the urine during the treatment indicate an endocrinous mechanism of this therapeutic effect. An efficacy of the method in extensive dissemination of the process, its relative simplicity and availability along with the absence of serious complications enabled the authors to hope that the suggested method may be widely used in practice.
mesh_terms: D015068:17-Ketosteroids / Q000652:urine; D000328:Adult; D000368:Aged; D001859:Bone Neoplasms / Q000188:drug therapy* / Q000628:therapy / Q000652:urine; D001943:Breast Neoplasms / Q000188:drug therapy* / Q000628:therapy / Q000652:urine; D004967:Estrogens / Q000652:urine; D005260:Female; D006801:Humans; D006854:Hydrocortisone / Q000008:administration & dosage*; D007278:Injections, Spinal; D008875:Middle Aged; D009362:Neoplasm Metastasis
chemical_list: D015068:17-Ketosteroids; D004967:Estrogens; D006854:Hydrocortisone
vernacular_title: Endoliumbal'noe vvedenie gidrokortizona v kompleksnom lechenii bol'nykh generalizovannym rakom molochnoĭ zhelezy