[4 cases of hemolytic autoimmune anemia and idiopathic thrombopenic purpura with anti-native DNA antibodies].
Four cases (1 female and 3 male) of autoimmune hemolytic anemia (AHA) and idiopathic thrombocytopenia purpura of 13-34 years' duration are reported. All have antibodies against native DNA, low complement levels and positive Coombs test. In 2, circulating immune complexes were found. Renal biopsies in 3 revealed small deposits of immunoglobulin and complement in the mesangium of glomerula. No inflammatory changes were seen in light microscopy. These patients thus resemble the animal model of NZB mice, which exhibit similar AHA with antibodies to DNA but with minimal renal changes.
D000328:Adult; D000744:Anemia, Hemolytic, Autoimmune / Q000150:complications*; D001323:Autoantibodies; D004247:DNA; D005260:Female; D006801:Humans; D007678:Kidney Glomerulus / Q000276:immunology; D008297:Male; D008875:Middle Aged; D011696:Purpura, Thrombocytopenic / Q000150:complications*
D001323:Autoantibodies; D004247:DNA
Quatre cas d'anémie hémolytique autoimmune et de purpura thrombopémique idiopathique avec anticorps contre le DNA natif