Toxicological findings in victims of traumatic deaths.
The toxicological findings from 6037 analyses of viscera obtained from victims of traumatic death are used to correlate the relative incidence of carbon monoxide, ethyl alcohol, narcotics, hypnotics, analgesics, and tranquilizers-antidepressants in deaths occurring under the following circumstances: fire related, asphyxia by hanging, by use of plastic bags, from physical obstruction of trachae, and by drowning; traumatic injury from impact of moving train, fall from height, and occupational accident; traumatic injury to pedestrian, driver, and passenger from vehicular accidents; and from violent death by shooting, stabbing, strangulation, and beating. The influence of alcohol, narcotic drugs, and tranquilizers on carbon monoxide can be seen in some of these traumatic deaths. Ethanol alone and in combination with other drugs was present in 42.3% and 19.5% of driver and pedestrian victims, respectively, of vehicular accidents in the year 1974. Comparative analysis is presented for the toxicological data obtained on victims of homicide (shooting, stabbing, strangulation, and beating) in New York City and similar data reported for victims of homicide in Detroit. In New York City 45.9% of such victims died while under the influence of alcohol or narcotic drugs, or both, with methadone predominating in the latter category. Tissue concentrations of drugs found in victims of traumatic death are presented. Diphenylhydantoin, diazepam, meperidine, and slow-acting barbiturates were found in normal therapeutic levels. Higher concentrations of amitriptyline, chlorpromazine, propoxyphene, short-acting barbiturates, and methadone were observed. The concentration of methadone in blood and brain (0.13 +/- 0.14 mg/100 ml) and in liver (0.53 +/- 0.42 mg/100 ml) in cases of traumatic death are not different from those observed in deaths classified as due to methadone overdose.
D000059:Accidents; D001741:Black or African American; D000700:Analgesics / Q000032:analysis; D001344:Autopsy; D002249:Carbon Monoxide Poisoning / Q000453:epidemiology; D000431:Ethanol / Q000032:analysis; D005260:Female; D005554:Forensic Medicine; D006708:Homicide; D006801:Humans; D006993:Hypnotics and Sedatives / Q000032:analysis; D008099:Liver / Q000032:analysis; D008297:Male; D008824:Michigan; D009294:Narcotics / Q000032:analysis; D009519:New York City; D004364:Pharmaceutical Preparations / Q000032:analysis*; D012737:Sex Factors; D014149:Tranquilizing Agents / Q000032:analysis; D014947:Wounds and Injuries / Q000097:blood / Q000401:mortality*
D000700:Analgesics; D006993:Hypnotics and Sedatives; D009294:Narcotics; D004364:Pharmaceutical Preparations; D014149:Tranquilizing Agents; D000431:Ethanol