Reversible encephalopathy following cephacetril therapy in high doses in a patient on chronic intermittent hemodialysis.
A patient on chronic intermittent hemodialysis at home showed signs of acute encephalopathy after an 8-day's treatment with a total dose of 78 g cephacetril (Celospor). Features included papilledema, loss of visual fields, severe generalized EEG changes and bilateral occipital abnormalities on a brain scintigram. Psychopathological findings consisted of a severe psychosis. The visual fields defects were the last sign of the encephalopathy to disappear.
D000038:Abscess / Q000188:drug therapy; D001424:Bacterial Infections / Q000188:drug therapy; D002505:Cephacetrile / Q000008:administration & dosage / Q000009:adverse effects*; D002511:Cephalosporins / Q000009:adverse effects*; D005260:Female; D006801:Humans; D008875:Middle Aged; D019965:Neurocognitive Disorders / Q000139:chemically induced*; D006435:Renal Dialysis
D002511:Cephalosporins; D002505:Cephacetrile