[On the method of injecting into the yolk-sac in teratological studies in rabbits (author's transl)].
A method is described by which the embryotoxic and teratogenic effects of substances can be examined through their application into the yolk-sac. On the ninth day of gestation rabbits (white New Zealand) were laparatomised and the uterus bicornis together with the blastoderms were treated in 3 different experiments. The results show that after application of physiological saline into the yolk-sac the high rate of malformations and resorptions are caused mainly by an avoidable venous obstruction and by postoperative inflammations and infections.
D000014:Abnormalities, Drug-Induced; D000042:Absorption; D000818:Animals; D004353:Drug Evaluation, Preclinical / Q000379:methods*; D005260:Female; D007267:Injections / Q000379:methods*; D011247:Pregnancy; D011817:Rabbits; D013723:Teratogens / Q000008:administration & dosage; D014817:Vitelline Membrane / Q000187:drug effects
D013723:Teratogens
Zur Methode der Applikation in den Dottersack bei teratologischen Untersuchungen an Kaninchen