Pharmacological study of a new substance, mecinarone.
Mecinarone, a benzofuranic chalcone, shows considerable vasodilating activity on the peripheral and cerebral circulation. The intramuscular irrigation is thus improved and the cerebral blood supply increased. This vasodilating activity is accompanied by only a slight drop in the systemic arterial pressure and occurs without cardiac depression. Mecinarone has also antibradykinin, antiserotonin and antiaggregation properties which added to the vasodilating activity, greatly increase its pharmacological interest.
D000284:Administration, Oral; D000818:Animals; D001572:Benzofurans / Q000008:administration & dosage / Q000494:pharmacology* / Q000633:toxicity; D002199:Capillary Permeability / Q000187:drug effects; D002560:Cerebrovascular Circulation / Q000187:drug effects; D002599:Chalcone / Q000031:analogs & derivatives / Q000494:pharmacology* / Q000633:toxicity; D004231:Diuresis / Q000187:drug effects; D004285:Dogs; D005260:Female; D005263:Femoral Artery; D006439:Hemodynamics / Q000187:drug effects; D007275:Injections, Intravenous; D007928:Lethal Dose 50; D008297:Male; D051379:Mice; D009132:Muscles / Q000098:blood supply; D010974:Platelet Aggregation / Q000187:drug effects; D011427:Propiophenones / Q000494:pharmacology*; D051381:Rats; D012039:Regional Blood Flow / Q000187:drug effects; D012119:Respiration / Q000187:drug effects
D001572:Benzofurans; D011427:Propiophenones; D002599:Chalcone