[Dynamics of furazolidone absorption and elimination in the body of rats administered prednisolone and butadion].
In experiments set up on rats the dynamics of furazolidone concentration in the organism on its introduction into the stomach in possible combinations with prednisolone and butadion was studied. As evidenced, when in combination with the said drugs the blood furazolidone concentration enhances quite significantly, this being especially ostensible in cases of simultaneous introduction of prednisolone and butadion, mainly because of a delayed elimination of furazolidone with urine. No correlation between the furazolidone concentration dynamics in the gastro-intestinal tract and in the blood was noted.
D000818:Animals; D001702:Biopharmaceutics; D004347:Drug Interactions; D005664:Furazolidone / Q000378:metabolism* / Q000652:urine; D007408:Intestinal Absorption / Q000187:drug effects*; D008297:Male; D010653:Phenylbutazone / Q000494:pharmacology*; D011239:Prednisolone / Q000494:pharmacology*; D051381:Rats; D013997:Time Factors
D005664:Furazolidone; D011239:Prednisolone; D010653:Phenylbutazone
Dinamika vsasyvaniia i éliminatsii furazolidona v organizme krys pri vvedenii s prednizolonom i butadionom