Blood group activity of allergenic preparations.
Haemagglutination-inhibition studies showed that several different allergenic preparations exhibit A and B blood group activity. Most products displayed A-specificity, less often B-specificity; the inhibition titers were usually low. No correlation was evident between isoagglutination-inhibition titers and the complement-consuming capacity or skin-reactivity of the allergens. Absorption of A- and B-isoagglutinins from human serum did not affect the complement consumption by house dust allergens. Hapten-inhibition studies confirmed the non-participation of blood group antibodies in allergen-induced complement consumption. The observed inhibition by D-glucosamine is attributed to a partial structural homology with the lysine-sugar site on house dust allergens.
D000017:ABO Blood-Group System; D000485:Allergens; D000906:Antibodies; D000937:Antigen-Antibody Reactions; D003165:Complement System Proteins; D004391:Dust; D006385:Hemagglutination Inhibition Tests; D006801:Humans; D007106:Immune Sera; D012882:Skin Tests
D000017:ABO Blood-Group System; D000485:Allergens; D000906:Antibodies; D004391:Dust; D007106:Immune Sera; D003165:Complement System Proteins