Inhibition of water absorption in the intestine by Staphylococcus aureus delta-toxin.
Water absorption in intestinal segments was monitored by measuring the concentration of polyethylene glycol, a nonabsorbable reference marker, in a balanced salt solution continuously perfused through the lumen. Staphylococcus aureus delta-toxin inhibited water absorption in rabbit jejunum and ileum perfused in vivo and in guinea pig ileum perfused in vitro. Cholera toxin also interfered with water absorption in guinea pig ileum maintained in vitro, but S. aureus enterotoxin B had no demonstrable effect on this tissue.
D000818:Animals; D001692:Biological Transport; D004305:Dose-Response Relationship, Drug; D006168:Guinea Pigs; D007082:Ileum / Q000378:metabolism*; D007583:Jejunum / Q000378:metabolism*; D010477:Perfusion; D011817:Rabbits; D013211:Staphylococcus aureus; D014118:Toxins, Biological / Q000494:pharmacology*; D014882:Water-Electrolyte Balance
D014118:Toxins, Biological