[Study of serum beta-N-acetylglucosaminidase activity in white rats treated with 1,2-dichloroethane].
In the course of a three-month long, chronic experiment using white male rats, the organic solvent 1,2-dichlorethane was administered per os at the following doses: 1/5000, 1/1000 and 1/200 LD50. The activity of the lysosome enzyme beta-N-acetylglucosaminidase is studied. A statistically significant increase (p less than 0.02) is established in the two higher doses.
D000118:Acetylglucosaminidase / Q000097:blood*; D000818:Animals; D004305:Dose-Response Relationship, Drug; D004789:Enzyme Activation / Q000187:drug effects; D005025:Ethylene Dichlorides / Q000506:poisoning*; D006596:Hexosaminidases / Q000097:blood*; D006843:Hydrocarbons, Chlorinated / Q000506:poisoning*; D007928:Lethal Dose 50; D008247:Lysosomes / Q000201:enzymology; D008297:Male; D011041:Poisoning / Q000201:enzymology; D051381:Rats; D013268:Stimulation, Chemical
D005025:Ethylene Dichlorides; D006843:Hydrocarbons, Chlorinated; D006596:Hexosaminidases; D000118:Acetylglucosaminidase
Izsledvane na beta-N-atsetilgliukozaminidaznata aktivnost v seruma pri beli plukhove, tretirani s 1,2-dikhloretan.