title: [Hypertensive disease as membrane pathology].
abstract: A hypothesis is presented that suggests that essential hypertension and its analog -- spontaneous hypertension in rats originates from a genetically determined defect of the permeability of the cell membranes. An increasing permeability of the membranes for potassium and sodium may serve as a common cause of activation of the servomechanisms that provide for the elevation of the arterial blood pressure. A chronic psychoemotional stress, salt or corticosteroid overloading are the conditions that display a latent membranous insufficiency.
mesh_terms: D000818:Animals; D002463:Cell Membrane Permeability; D006801:Humans; D006973:Hypertension / Q000209:etiology* / Q000378:metabolism; D007668:Kidney / Q000378:metabolism; D009318:Natriuresis; D051381:Rats; D011919:Rats, Inbred Strains; D012964:Sodium / Q000378:metabolism; D013315:Stress, Psychological; D014883:Water-Electrolyte Imbalance / Q000150:complications / Q000209:etiology
chemical_list: D012964:Sodium
vernacular_title: Gipertonicheskaia bolezn' kak membrannai patologiia