[Effect of 7 days of administration of prednisolone and methandrostenolone on the incorporation of glycine-1-c14 into liver, thymus and splenic proteins].
Daily injections of prednisolone (10 mg/kg) for a space of 7 days to albino male-rats cause an increased synthesis of nuclear and mitochondrial proteins without changing the protein synthesis of other liver fractions. Following injection of prednisolone the protein synthesis in the spleen went up and in the thymus remained unchanged. This was paralleled by stronger decay processes of the lymphoid organs. Under identical conditions methandrostenon intensified the proteins synthesis in the nuclear fraction of the liver alone. It made run low the processes of the thymus and spleen proteins biosynthesis without affecting materially the weight of the lymphoid organs.
D000818:Animals; D002250:Carbon Radioisotopes; D005998:Glycine / Q000378:metabolism*; D008099:Liver / Q000187:drug effects* / Q000378:metabolism; D008297:Male; D008696:Methandrostenolone / Q000008:administration & dosage*; D008862:Microsomes, Liver / Q000378:metabolism; D008930:Mitochondria, Liver / Q000378:metabolism; D011239:Prednisolone / Q000008:administration & dosage*; D014176:Protein Biosynthesis; D051381:Rats; D013154:Spleen / Q000187:drug effects* / Q000378:metabolism; D013950:Thymus Gland / Q000187:drug effects* / Q000378:metabolism; D013997:Time Factors
D002250:Carbon Radioisotopes; D011239:Prednisolone; D008696:Methandrostenolone; D005998:Glycine
Vliianie 7-dnevnogo vvedeniia prednizolona i metandrostenolona na vkliuchenie glitsina-1-C14 v belki pecheni, timusa i selezenki