New alpha-substituted arylthioacetic derivatives forming analogues of clofibrate.
Synthesis of some alpha-substituted arylthioacetic acids and esters forming analogues of clofibrate and of nafenopin (SU-13437) is reported and discussed. With a view to evaluating the influence of the introduction of a sulphur atom on the blood-lipid-reducing activity, preliminary pharmacological tests have been carried out on alpha-[4-(1-tetralyl)phenylthio] isobutyric acid (XIV) in parallel with its well-known phenoxy isologue. The results obtained so far, do not show any significant difference between the two compounds.
D000818:Animals; D002087:Butyrates / Q000138:chemical synthesis / Q000627:therapeutic use; D002994:Clofibrate / Q000031:analogs & derivatives*; D006949:Hyperlipidemias / Q000188:drug therapy; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D009255:Nafenopin / Q000031:analogs & derivatives; D051381:Rats; D013440:Sulfides / Q000138:chemical synthesis
D002087:Butyrates; D013440:Sulfides; D009255:Nafenopin; D002994:Clofibrate