A new series of benzodiazepines. 1-Hydroxyalkyl derivatives of 1,3-dihydro-2H-1,4-benzodiazepin-2-ones.
A series of new 1-hydroxyalkyl derivatives of 1,3-dihydro-2H-1,4-benzodiazepin-2-ones bearing a 3-hydroxyl or a 4-N-oxide function together with some related compounds have been synthesized. Compound (22) [1-(2-hydroxyethyl)-3-hydroxy-7-chloro-1,3-dihydro-5-(o-fluorophenyl)-2H-1,4-benzodiazepin-2-one] has been selected for further studies both in animals and in humans as an antianxiety-sedative agent.
D000438:Alcohols / Q000138:chemical synthesis; D001570:Benzodiazepinones / Q000138:chemical synthesis*; D003497:Cyclic N-Oxides / Q000138:chemical synthesis; D008722:Methods
D000438:Alcohols; D001570:Benzodiazepinones; D003497:Cyclic N-Oxides