Core formation in the muscles of rats intoxicated with triethyltin sulfate.
Young adult Osbourne-Mendel rats intoxicated for up to 23 days with triethyltin sulfate (TET) at a dose of 20 mg/liter of drinking water given ad libitum, developed core-like structures in type 1 extrafusal fibers of the soleus muscles. Frozen sections revealed an absence of oxidative enzyme activity (NADH-tetrazolium reductase) and diminished or absent myosin ATPase (pH 9.4) in the core regions. The main electron microscopic features within the cores were loss of mitochondria and streaming of the Z-disks. The histochemical and electron microscopic similarities and differences between the TET-induced cores, other core models, and those reported in some human neuromuscular disorders are discussed. The present experiments do not clarify whether the cores are produced from a direct effect of TET upon skeletal muscle or upon the neural component of the motor unit.
D000818:Animals; D001835:Body Weight / Q000187:drug effects; D001929:Brain Edema / Q000139:chemically induced; D003402:Creatine Kinase / Q000378:metabolism; D005260:Female; D008297:Male; D008931:Mitochondria, Muscle / Q000648:ultrastructure; D009045:Motor Endplate / Q000648:ultrastructure; D009132:Muscles / Q000201:enzymology / Q000648:ultrastructure*; D009186:Myelin Sheath / Q000648:ultrastructure; D051381:Rats; D014220:Trialkyltin Compounds / Q000506:poisoning*; D014267:Triethyltin Compounds / Q000494:pharmacology / Q000506:poisoning*; D014855:Wallerian Degeneration
D014220:Trialkyltin Compounds; D014267:Triethyltin Compounds; D003402:Creatine Kinase