The mechanism of anti-muricidal effects of chlordiazepoxide.
Muricidal activity of rats is suppressed by chlordiazepoxide (CDP). At appropriate doses the CDP effect is reversed by repeated testing, by pretreatment with CDP, and by concomitant dosing with caffeine. This points to the general behavioral depressant action of CDP which undergoes tolerance as being primarily responsible for the anti-muricidal activity of CDP.
D000374:Aggression / Q000187:drug effects*; D000818:Animals; D002110:Caffeine / Q000494:pharmacology; D002707:Chlordiazepoxide / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D003864:Depression, Chemical; D004361:Drug Tolerance; D005260:Female; D006801:Humans; D051379:Mice; D051381:Rats; D011930:Reaction Time / Q000187:drug effects; D013997:Time Factors
D002110:Caffeine; D002707:Chlordiazepoxide