[ The effect of prostaglandin E1 and noradrenaline on the tone of cerebral vessels and arterial pressure].
Acute experiments were conducted on cats; it was found that prostaglandine (PG) E1 produced a contrary effect on the tone of the cerebral vessels and on systemic arterial pressure depending on the presence of ethanol in its solution. Blocking of PG biosynthesis with indometacine promoted a marked increase in the vasoconstrictor reaction of the cerebral vessels and aided elevation of arterial pressure in response to noradrenaline administration. It is supposed that disturbance of PG biosynthesis in the organism could play a definite role in the genesis of hypertension and cerebrovascular disturbances.
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects*; D002415:Cats; D002560:Cerebrovascular Circulation / Q000187:drug effects*; D004347:Drug Interactions; D009638:Norepinephrine / Q000494:pharmacology*; D011453:Prostaglandins / Q000502:physiology; D011458:Prostaglandins E / Q000494:pharmacology*; D014655:Vascular Resistance / Q000187:drug effects
D011453:Prostaglandins; D011458:Prostaglandins E; D009638:Norepinephrine
Vliianie prostaglandina E1 i noradrenalina na tonus mozgovykh sosudov i arterial'noe davlenie