[Mechanism of the hypothermic action of reversible cholinesterase inhibitors].
Experiments set up on mice demonstrated that galanthamine, hydrobromide, physostymine salicilate and iodomethylate produce a fall of the renal temperature, the hypothermal effect being proportional to the suppression of the cerebral cholinesterase. Anticholinergics benactyzine and atropine were largely capable of preventing hypothermia produced by the introduction of galathamine hydrobromide, the latter increasing the resistance of the animals to the action of high temperature.
D000818:Animals; D001285:Atropine / Q000494:pharmacology; D001535:Benactyzine / Q000494:pharmacology; D001831:Body Temperature / Q000187:drug effects; D001921:Brain / Q000201:enzymology; D002746:Chlorpromazine / Q000494:pharmacology; D002800:Cholinesterase Inhibitors / Q000494:pharmacology*; D004158:Diphenylacetic Acids / Q000494:pharmacology; D004347:Drug Interactions; D004794:Enzyme Repression / Q000187:drug effects; D005702:Galantamine / Q000031:analogs & derivatives / Q000494:pharmacology; D006615:Hip; D007035:Hypothermia / Q000139:chemically induced*; D051379:Mice; D009132:Muscles / Q000201:enzymology; D010830:Physostigmine / Q000031:analogs & derivatives / Q000494:pharmacology; D010880:Piperidines / Q000494:pharmacology; D011427:Propiophenones / Q000494:pharmacology; D012007:Rectum; D012621:Seasons; D013696:Temperature; D013997:Time Factors
D002800:Cholinesterase Inhibitors; D004158:Diphenylacetic Acids; D010880:Piperidines; D011427:Propiophenones; D005702:Galantamine; D001535:Benactyzine; D001285:Atropine; D010830:Physostigmine; D002746:Chlorpromazine
K mekhanizm gipotermicheskogo deĭtviia obratimykh ingibitorov kholinésterazy