[Trichothecene inactivation by proteolytic enzymes from Trichothecium roseum Lk ex Fr].
Trichothecium roseum Lk ex Fr produces simultaneously trichothecin and proteolytic enzymes possessing fibrinolytic, thrombolytic and esterase activity. In addition to the function of splitting and consuming the substrate, the proteolytic enzymes of T. roseum are probably able to hydrolize the other bond in the molecule of trichothecin, which results in partial inactivation of the antibiotic in both the fungus culture and the model experiment on trichothecin contact with the preparations of the proteolytic enzymes. Presence of proteases of T. roseum may be considered as a protective mechanism for detoxication of the metabolites toxic for the organism.
D000935:Antifungal Agents / Q000037:antagonists & inhibitors* / Q000096:biosynthesis / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D004347:Drug Interactions; D005342:Fibrinolysis / Q000187:drug effects; D003904:Mitosporic Fungi / Q000201:enzymology*; D010447:Peptide Hydrolases / Q000494:pharmacology*; D012717:Sesquiterpenes / Q000037:antagonists & inhibitors*; D014255:Trichothecenes / Q000037:antagonists & inhibitors*
D000935:Antifungal Agents; D012717:Sesquiterpenes; D014255:Trichothecenes; D010447:Peptide Hydrolases
Inaktivatsiia trikhotetsina proteoliticheskikmi fermentami Trichothecium roseum Lk ex Fr