Chromosomes and causation of human cancer and leukemia. XIV. Origin of a large number of markers in a cancer.
A cancerous effusion from a patient with cancer of the breast, with a high modal number of chromosomes (81-83) and with 11-13 abnormal chromosomes (markers) of eight different origins, has been examined in detail karyotypically with C-, G-, and Q-banding techniques. Except for a rare chromosome, all the normal chromosomes were identified and, more importantly, the origin of all markers was ascertained. This study indicates the feasibility of identifying all the chromosomes in cancer cells, even in those with highly polyploid and complicated chromosome constitutions.
D000230:Adenocarcinoma / Q000235:genetics*; D000368:Aged; D001943:Breast Neoplasms / Q000235:genetics*; D002869:Chromosome Aberrations; D002901:Chromosomes, Human, 13-15; D002906:Chromosomes, Human, 6-12 and X; D002999:Clone Cells; D005260:Female; D006801:Humans; D007621:Karyotyping / Q000379:methods; D010996:Pleural Effusion / Q000166:cytology; D011123:Polyploidy; D014178:Translocation, Genetic