Hypothalamo-neurohypophysial complex in leukemia L 1210-bearing mice.
Mice of the DBA strain were inoculated with 4.5 x 10(6) L1210 ascites cells and the time response of the hypothalamo-neurohypophysial complex was studied. The amount of neurosecretory material was determined in the neuroendocrine cells of supraoptic and paraventricular nuclei, throughout the hypothalamo-neurohypophysial tract and in the neural lobe of the hypophysis. Three methods of response evaluation were employed: the amoount of neurosecretory material was estimated according to an arbitrary scale, by cytophotometry while for the hypothalamic cell-nuclei the karyometric method was used. The existence of a functional interrelation between the presence of leukemic cells and the activity of the hormonogenic sites in the hypothalamus is suggested. A clear response to the tumor inoculation was established both in the amount of stainable substance and in the nuclear volume of the secretory neurones. It is suggested that an accelerated synthesis and release of neurosecretory material in tumor recipient mice reduces renal excretion in order to compensate a dehydration caused by the production of ascitic fluid.
D000818:Animals; D002467:Cell Nucleus; D007030:Hypothalamo-Hypophyseal System / Q000503:physiopathology*; D007939:Leukemia L1210 / Q000503:physiopathology*; D051379:Mice; D008811:Mice, Inbred DBA; D009489:Neurosecretion; D010286:Paraventricular Hypothalamic Nucleus / Q000166:cytology; D013495:Supraoptic Nucleus / Q000166:cytology