[Estrogenic action of cardiac glycosides. Clinical and animal experiment studies].
Vaginal smears of young girls before puberty and of postmenopausal women who were treated with digoxine, were examined on their degree of proliferation. There was no sign of any estrogenic stimulation. In female juvenile and ovarectomized fertile rats digitoxin caused no ripening of the vaginal epithelium neither in low nor in high doses. It is supposed that some steroid-hormone-like effects which are seen by glycoside-therapy, are related to stimulation of the suprarenal gland.
D000367:Age Factors; D000818:Animals; D002301:Cardiac Glycosides / Q000494:pharmacology*; D002455:Cell Division / Q000187:drug effects; D002648:Child; D004074:Digitoxin / Q000494:pharmacology; D004847:Epithelial Cells; D004848:Epithelium / Q000187:drug effects; D004967:Estrogens / Q000494:pharmacology; D005260:Female; D006801:Humans; D008593:Menopause; D008875:Middle Aged; D010053:Ovary / Q000601:surgery; D011627:Puberty; D051381:Rats; D011919:Rats, Inbred Strains; D014621:Vagina / Q000187:drug effects*; D014626:Vaginal Smears
D002301:Cardiac Glycosides; D004967:Estrogens; D004074:Digitoxin
Zur östrogenen Wirksamkeit von Herzglykosiden. Klinische und tierexperimentelle Untersuchungen