title: Neurofibrillary changes after acute experimental lead poisoning.
abstract: Following acute tetraethyllead intoxication in rabbits classic neurofibrillary tangles develop. As studied by electron microscopy, such tangles develop in hydropic degenerating neurons and consist primarily of bundles of 200 A diameter smooth tubules of enormous length. In two of 16 animals a few twisted tubules (periodicity of 800 A) also could be found. The significance of these lead-induced twisted tubules, so characteristic of Alzheimer's pre-senile dementia in man, is discussed.
mesh_terms: D000208:Acute Disease; D000818:Animals; D001921:Brain / Q000648:ultrastructure*; D002525:Cerebellar Cortex / Q000648:ultrastructure; D005625:Frontal Lobe / Q000648:ultrastructure; D006624:Hippocampus / Q000648:ultrastructure; D007855:Lead Poisoning / Q000473:pathology*; D008297:Male; D008870:Microtubules / Q000648:ultrastructure; D009454:Neurofibrils / Q000648:ultrastructure*; D011817:Rabbits