Central adrenergic neurons in DOCA-salt hypertension.
The effects of various doses of 6-hydroxydopamine (6-OHDA) injected into the hypothalamus on DOCA-salt-induced hypertension were studied. The development of hypertension was prevented in the group treated with the highest dose of 6-OHDA, and the onset of hypertension was delayed in a dose-dependent fashion in the groups treated with the lower doses of 6-OHDA. Catecholamine histofluorescence observations showed that the cannula tips placed the drug lateral to the third ventricle. The most prominent change observed was a marked unilateral reduction in the fluorescence of the dopaminergic nerves of the caudate-putamen and in the number of cell bodies in the substantia nigra. These results suggest possible sites of central aminergic control of blood pressure.
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D002421:Caudate Nucleus / Q000187:drug effects; D002552:Cerebral Ventricles / Q000187:drug effects*; D003900:Desoxycorticosterone; D004305:Dose-Response Relationship, Drug; D006892:Hydroxydopamines / Q000494:pharmacology*; D006973:Hypertension / Q000139:chemically induced*; D007031:Hypothalamus / Q000187:drug effects; D008297:Male; D009410:Nerve Degeneration / Q000187:drug effects; D011699:Putamen / Q000187:drug effects; D051381:Rats; D013378:Substantia Nigra / Q000187:drug effects
D006892:Hydroxydopamines; D003900:Desoxycorticosterone