[The antibacterial action of the amoxicillin-flucloxacillin combination].
A mixture of amoxycillin, semisynthetic penicillin beta-lactamase susceptible, and flucloxacillin, an isoxazolylpenicillin, in combination 1:1 was tested. This mixture shows real synergic effect "in vitro" on beta-lactamase producing Gram-positive and Gramnegative bacteria and an additive effect on the other microrganisms. Good results have been obtained "in vivo" and a protective effect of flucloxacillin on enzymatic degradation of amoxycillin by beta-lactamase was found.
D000658:Amoxicillin / Q000494:pharmacology*; D000667:Ampicillin / Q000031:analogs & derivatives*; D000818:Animals; D001419:Bacteria / Q000187:drug effects*; D003023:Cloxacillin / Q000031:analogs & derivatives*; D004338:Drug Combinations; D005436:Floxacillin / Q000494:pharmacology*; D051379:Mice; D008826:Microbial Sensitivity Tests; D012481:Salmonella Infections, Animal / Q000188:drug therapy*; D013203:Staphylococcal Infections / Q000188:drug therapy*
D004338:Drug Combinations; D005436:Floxacillin; D000667:Ampicillin; D000658:Amoxicillin; D003023:Cloxacillin
Sull'attivita' antibatterica dell'associazione amoxicillina-flucloxacillina