[Metabolism of 3-amino-1,2,4-triazole in rats].
3-Amino-1,2,4-triazole[5-(14)C] was administered orally to rats as a single dose of 50 mg/kg body weight. Excretion in urine and feces was followed during a period of 3 days. Within the first 24 hrs the main part of the radioactivity was found in the urine as unchanged amitrole. 3-Amino-5-mercapto-1,2,4-triazole and 3-amino-1,2,4-triazolyl-(5)-mercapturic acid were isolated from urine and identified by comparison with synthetic compounds. The total amount of these metabolites in the urine was about 6% of the dose. The metabolic pathways of amitrole and the possible relations between biotransformation and toxicity are discussed.
D000111:Acetylcysteine / Q000652:urine; D000640:Amitrole / Q000378:metabolism* / Q000633:toxicity; D000818:Animals; D001711:Biotransformation; D008297:Male; D051381:Rats; D013438:Sulfhydryl Compounds / Q000652:urine; D014230:Triazoles / Q000378:metabolism* / Q000652:urine
D013438:Sulfhydryl Compounds; D014230:Triazoles; D000111:Acetylcysteine; D000640:Amitrole
Uber den Stoffwechsel von 3-Amino-1,2,4-triazol in Ratten