[The effects of actinomycin D on the brain RNA synthesis and on the passive avoidance latency in the goldfish (author's transl)].
(a) Intracranial injection of actinomycin D (2 mug/10 mul/fish) inhibited about 70% of the goldfish brain RNA synthesis from 3 hours to 4 days later. (b) The goldfish injected actinomycin D intracranially was given the passive avoidance training. Intraday-acquisition (short-term memory) was not blocked but interday-retention (long-term memory) was markedly blocked. It might suggest that the brain RNA synthesis is not related to short-term memory but is necessary for long-term memory.
D000818:Animals; D001921:Brain / Q000378:metabolism*; D003609:Dactinomycin / Q000494:pharmacology*; D006054:Goldfish; D008568:Memory / Q000187:drug effects; D008570:Memory, Short-Term / Q000187:drug effects; D013997:Time Factors
D003609:Dactinomycin