title: Expression of H-Y antigen in human males with two Y chromosomes.
abstract: To determine whether the gene that controls the expression of H-Y ("male") antigen on human cells is Y-linked, we have compared the H-Y antigen level in normal males with that in three males with two Y chromosomes. Leukocytes from one XXYY and two XYY males express more H-Y antigen than leukocytes from normal XY males. We conclude that a structural gene or positive regulatory gene for H-Y antigen is on the human Y chromosome. Testing for the H-Y antigen may be of benefit in patients who have signs of masculinization but who lack an identifiable Y chromosome. Positive results for the H-Y antigen would be tentative evidence that the corresponding region of the Y chromosome was present, perhaps as part of a translocation, despite the absence of a typical Y chromosome.
mesh_terms: D000042:Absorption; D000328:Adult; D000818:Animals; D000921:Antibody-Producing Cells; D002874:Chromosome Mapping; D003429:Cross Reactions; D003601:Cytotoxicity Tests, Immunologic; D005260:Female; D006382:Hemadsorption; D006649:Histocompatibility Antigens; D006801:Humans; D007104:Immune Adherence Reaction; D007106:Immune Sera; D007231:Infant, Newborn; D008297:Male; D051379:Mice / Q000276:immunology; D010641:Phenotype; D012729:Sex Chromosome Aberrations / Q000235:genetics* / Q000276:immunology; D012730:Sex Chromosomes; D012732:Sex Determination Analysis; D013094:Spermatozoa / Q000276:immunology; D014178:Translocation, Genetic
chemical_list: D006649:Histocompatibility Antigens; D007106:Immune Sera