title: A differential viability model for twin-pair blood group data.
abstract: Much interest in human genetics studies of blood systems is focussed on the possible incompatibility of discordant twin pairs. Here we discuss a differential viability model which accounts for deviations from the standard multinomial model for twin pair data based on the Hardy-Weinberg frequencies. We discuss related estimation and testing problems, illustrating the techniques with data from the Louisville Twin Study.
mesh_terms: D000483:Alleles; D001789:Blood Group Antigens; D005260:Female; D005826:Genetics, Medical; D006801:Humans; D008297:Male; D008954:Models, Biological; D010641:Phenotype; D011247:Pregnancy; D013223:Statistics as Topic; D014427:Twins
chemical_list: D001789:Blood Group Antigens