[Taste disorders and liver parenchymal damage after administration of thiamazole (author's transl)].
Marked, and in some cases long-lasting, taste disturbances occurred in three patients on thiamazole. In addition, all three had a rise in serum transaminases and alkaline phosphatase levels, due to associated liver parenchymal damage. Cause of these changes was the high thiamazole dosage (160 and 120 mg/d). Reduction in dosage restored normal taste sense in all three, but in two the drug had to be discontinued because of persisting high transaminase levels.
D000328:Adult; D056486:Chemical and Drug Induced Liver Injury; D005260:Female; D006801:Humans; D006980:Hyperthyroidism / Q000188:drug therapy; D008713:Methimazole / Q000008:administration & dosage / Q000009:adverse effects*; D008875:Middle Aged; D013651:Taste Disorders / Q000139:chemically induced*; D013997:Time Factors
D008713:Methimazole
Geschmacksstörungen und Leberparenchymschäden bei der Behandlung mit Thiamazol