Serum-free and protein-bound sugars and cardiovascular complications in diabetes mellitus.
Free and protein-bound serum sugars and serum lipids were analyzed in 65 adult diabetic patients, 10 age-matched controls, and 24 male medical students for correlation of carbohydrate changes with the extent of retinal, renal, and cardiovascular disease. In diabetic sera, both protein-bound sugars and free mannose, fucose, and hexosamine were significantly elevated; free galactose and inositol were elevated in some diabetic patients, and essentially undetectable in sera from controls. Serum triglycerides and pre-beta-lipoproteins were also elevated in diabetics, but alpha-lipoproteins decreased. Although no specific relationships were observed with the extent of retinal and renal disease, bivariate analyses by Pearson coefficients of correlation showed correlations between levels of serum-free mannose and systolic blood pressure, free hexosamine and duration of diabetes, and serum protein-bound fucose and age. Serum triglycerides and pre-beta-lipoprotein levels correlated with insulin therapy. These are preliminary leads of laboratory studies related to carbohydrate macromolecular changes which might aid in a better understanding of the cardiovascular complications associated with diabetes.
D000328:Adult; D000367:Age Factors; D000368:Aged; D000704:Analysis of Variance; D001786:Blood Glucose / Q000378:metabolism; D001794:Blood Pressure; D002318:Cardiovascular Diseases / Q000097:blood*; D048909:Diabetes Complications; D003920:Diabetes Mellitus / Q000097:blood*; D003925:Diabetic Angiopathies / Q000097:blood; D003928:Diabetic Nephropathies / Q000097:blood; D003930:Diabetic Retinopathy / Q000097:blood / Q000150:complications; D005260:Female; D005643:Fucose / Q000097:blood; D005693:Galactosemias / Q000150:complications; D006595:Hexosamines / Q000097:blood; D006801:Humans; D007294:Inositol / Q000097:blood; D008055:Lipids / Q000097:blood; D008297:Male; D008358:Mannose / Q000097:blood; D008875:Middle Aged; D011485:Protein Binding; D012794:Sialic Acids / Q000097:blood
D001786:Blood Glucose; D006595:Hexosamines; D008055:Lipids; D012794:Sialic Acids; D005643:Fucose; D007294:Inositol; D008358:Mannose