Immunosuppressive therapy and virus-cores in HBAg-positive chronic hepatitis.
Three liver biopsies were carried out in a case of chronic active hepatitis with persistent HB-antigenemia. Virus-cores could not be detected in the liver cell nuclei by electron microscopy before immunosuppressive therapy. Intranuclear, ring-shaped virus-cores of 20-25 nm diameter appeared in almost every hepatocyte examined during immunosuppression.
D002467:Cell Nucleus / Q000382:microbiology; D002908:Chronic Disease; D006506:Hepatitis A / Q000188:drug therapy* / Q000382:microbiology; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use*; D008099:Liver / Q000473:pathology
D007166:Immunosuppressive Agents