Carcinogenicity of 4-hydroxybutyl-butylnitrosamine in Syrian hamsters.
4-Hydroxybutyl-butylnitrosamine (HBBN), a urinary metabolite of dibutylnitrosamine (DBN) was shown to induce respiratory and bile duct tumors as well as carcinomas of the urinary bladder in Syrian golden hamsters. This contrasts with results previously obtained in rats and demonstrates that HBBN is not a specific bladder carcinogen. Bronchogenic tumors, seen in DBN-treated hamsters, were not observed after injection of HBBN.
D000818:Animals; D001650:Bile Duct Neoplasms / Q000139:chemically induced*; D002273:Carcinogens; D006224:Cricetinae; D008647:Mesocricetus; D009374:Neoplasms, Experimental / Q000139:chemically induced; D009602:Nitrosamines / Q000378:metabolism / Q000633:toxicity*; D051381:Rats; D012142:Respiratory Tract Neoplasms / Q000139:chemically induced*; D013045:Species Specificity; D001743:Urinary Bladder / Q000378:metabolism; D001749:Urinary Bladder Neoplasms / Q000139:chemically induced*
D002273:Carcinogens; D009602:Nitrosamines