The cytogenetic effect of an X-ray contrast medium in Chinese hamster cell cultures.
Chinese hamster cell cultures were treated with different concentrations of Joduron, a water-soluble iodized X-ray contrast medium. The cytogenetic effect was analysed for a treatment period of 2 or 16 h. Jorudron primarily acts on the mitotic apparatus of the cell. The type of damage ranges from different forms of initial "C-mitosis" to unpolarized stathmokinesis. Additionally, structural chromosome damage, mainly of the chromatid type, was observed, especially after a Joduron treatment for 2 h.
D000818:Animals; D002460:Cell Line; D002478:Cells, Cultured; D002869:Chromosome Aberrations; D003287:Contrast Media; D006224:Cricetinae; D007621:Karyotyping; D008938:Mitosis; D013997:Time Factors
D003287:Contrast Media