title: [Digestive intolerance to cow's milk proteins in infants. Biological and histological study].
abstract: Biological and histological studies were performed in 42 cases of gastro-intestinal intolerance to cow's milk proteins. Hypoproteinemia was present in 2/3 of the cases, anemia in 3/4. Malabsorption syndrome (steatorrhea, xylose) was overt in less than 1 patient out of 2. Serum level of vitamin A was more frequently depressed than that of vitamin E and folinic acid. Intestinal biopsy, performed in 32 children, showed consistent abnormalities, a partial atrophy of the villi being most often seen (26 cases). Eosinophilia was present in 50% of the cases. A titer of anti-milk agglutinins of 1/64 or above was always found if the test was performed repeatedly when the diet of the children contained milk. Lymphocyte proliferation in culture, induced by milk proteins, was positive in 70% of the cases. None the less, no biological or histological findings were found to be specific for gastro-intestinal intolerance to milk proteins.
mesh_terms: D000373:Agglutinins / Q000032:analysis; D000818:Animals; D001798:Blood Proteins / Q000032:analysis; D002417:Cattle; D005512:Food Hypersensitivity / Q000473:pathology; D006801:Humans; D007223:Infant; D007413:Intestinal Mucosa / Q000473:pathology; D007421:Intestine, Small / Q000473:pathology*; D008894:Milk Proteins / Q000009:adverse effects*; D014815:Vitamins / Q000097:blood*
chemical_list: D000373:Agglutinins; D001798:Blood Proteins; D008894:Milk Proteins; D014815:Vitamins
vernacular_title: L'intolerance digestive aux proteines du lait de vache chez le nourrisson et l'enfant. Etude biologique et histologique