Pressor effects of tryptamine analogues.
1. Methylation of tryptamine in the 1-position had little effect on the potency of the drug as a pressor agent in the intact anaesthetized rat. 2. In contrast, substitution of a benzo[b]thiophene ring system for the indole ring decreased the pressor activity. 3. Pretreatment of the animals with reserpine reduced the pressor effect of tryptamine and its benzo[b]thiophene analogue while increasing the effect of the 1-methylindole analogue. 4. Pretreatment with phenoxybenzamine reduced the pressor effect of all three compounds.
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects*; D008297:Male; D010643:Phenoxybenzamine / Q000494:pharmacology; D012110:Reserpine / Q000494:pharmacology; D014363:Tryptamines / Q000037:antagonists & inhibitors / Q000494:pharmacology*
D014363:Tryptamines; D010643:Phenoxybenzamine; D012110:Reserpine