An unusual case of hemoglobin Bart's hydrops fetalis.
A baby with alpha-chain thalassemia hydrops fetalis was born to an Iraqian Jewish couple of Iraqi-Kurdish extraction. Hemoglobin Bart's constituted only 40% of the total hemoglobin, much less than usually found in alpha-thalassemia hydrops fetalis. That this is a particular expression of hemoglobin H disease is considered. The likelihood of two alpha-chain loci, rather than one alpha-chain locus, in this family, is also discussed.
D004487:Edema / Q000150:complications*; D005260:Female; D005315:Fetal Diseases / Q000150:complications*; D005796:Genes; D006447:Hemoglobin H / Q000032:analysis; D006455:Hemoglobins, Abnormal / Q000032:analysis*; D006801:Humans; D007231:Infant, Newborn; D010641:Phenotype; D011247:Pregnancy; D013789:Thalassemia / Q000150:complications* / Q000235:genetics
D006455:Hemoglobins, Abnormal; D006447:Hemoglobin H