[Experimental data on a new cholinesterase reactivator from the group of thiohydroximic esters].
Experimental data on the effectiveness of p-brombenzothiohydroximic S-diethylaminoethylate (diethyxime) -a new cholinesterase reactivator - are presented. The diethyximetoxicity with its single and multiple administration to animals was studied. The drug is shown to display a marked antidotal action when used in a dosage range of 490-10 mg/kg. Diethyxime is shown capable of restoring the activity of cholinesterase inhibited by dimethyldichlorovenylphosphate, of preventing the neuro-muscular block of the impulses conduction and of normalizing the function of the cardiovascular system. The drug is less toxic than is presently employed reactivator diproxime and it does not produce any side-effects on a number of organs and systems of the organism with its multiple administration to worm-blooded animals.
D000818:Animals; D000931:Antidotes / Q000494:pharmacology; D001285:Atropine / Q000494:pharmacology; D002415:Cats; D002801:Cholinesterase Reactivators / Q000494:pharmacology*; D004006:Dichlorvos / Q000506:poisoning; D004048:Diethylamines / Q000494:pharmacology; D004158:Diphenylacetic Acids / Q000494:pharmacology; D004353:Drug Evaluation, Preclinical; D004359:Drug Therapy, Combination; D005260:Female; D006168:Guinea Pigs; D006877:Hydroxamic Acids / Q000494:pharmacology*; D007928:Lethal Dose 50; D008297:Male; D051379:Mice; D009119:Muscle Contraction / Q000187:drug effects; D009431:Neural Conduction / Q000187:drug effects; D010091:Oximes; D011041:Poisoning / Q000188:drug therapy; D011817:Rabbits; D051381:Rats; D013997:Time Factors
D000931:Antidotes; D002801:Cholinesterase Reactivators; D004048:Diethylamines; D004158:Diphenylacetic Acids; D006877:Hydroxamic Acids; D010091:Oximes; C012284:diethyxime; D001285:Atropine; D004006:Dichlorvos
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