Effect of lymphotropic cytostatic agent in newborn and suckling mice.
The sensitivity of newborn and suckling mice to a lymphotropic cytostatic agent (DAD) was found to be increased as compared to adult mice. Results indicated that a single dose of DAD being ineffective in adult mice, caused irreversible impairment in the lymphoid system of newborn and suckling mice with underdeveloped lymphoid system. This led to the development of lethal wasting resembling the wasting syndrome. On the basis of its consequences the DAD treatment, applied in newborn age, may be considered as "cytostatic thymectomy".
D000375:Aging; D000818:Animals; D000831:Animals, Newborn; D004305:Dose-Response Relationship, Drug; D004988:Ethers, Cyclic / Q000494:pharmacology*; D008221:Lymphoid Tissue / Q000187:drug effects*; D051379:Mice; D009026:Mortality; D009929:Organ Size; D013154:Spleen / Q000033:anatomy & histology
D004988:Ethers, Cyclic