title: [Effect of DL-lactic acid on voluntary food intake in sheep (author's transl)].
abstract: Previous experiments indicate that changes in duodenal fluid concentration of DL-lactic and volatile fatty acids (VFA) influence flow rate of ingesta and may also be a regulating factor of food intake in ruminants. The present experiment was designed to determine the sensitivity of the duodenum to DL-lactic acid and VFA in relation to diets of hay, dried grass or concentrates. On a diet of hay, administration of small amounts of either DL-lactic acid or VFA into the duodenum had no effect. On a diet of dried grass or concentrates the same amount of VFA had no effect but that of DL-lactic acid (12 mM/h) halved the dry matter intake. In animals on a diet of hay and after administration of 40 g of propionate into the rumen, duodenal perfusion of the same quantity of DL-lactic acid produced a similar reduction of food intake. It was concluded that duodenal DL-lactic acid acts as a regulator of food intake possibly via the propionate metabolism pathway.
mesh_terms: D000821:Animal Feed; D000818:Animals; D004386:Duodenum / Q000378:metabolism; D004435:Eating; D005232:Fatty Acids, Volatile / Q000378:metabolism; D005260:Female; D005769:Gastrointestinal Motility; D007773:Lactates / Q000378:metabolism*; D000455:Medicago sativa; D006109:Poaceae; D011422:Propionates / Q000378:metabolism; D012417:Rumen / Q000378:metabolism / Q000502:physiology; D012756:Sheep / Q000378:metabolism* / Q000502:physiology
chemical_list: D005232:Fatty Acids, Volatile; D007773:Lactates; D011422:Propionates
vernacular_title: Rôle de l'acide DL-lactique dans le contrôle de l'ingestion alimentaire chez le mouton