[Mechanism of action of naphthylvinylpyridine].
Naphthylvinylpyridine (NVP) in the cat cerebral cortex (50 mg/kg) and in the mouse brain (100 and 250 mg kg) caused inhibition of choline acetyltransferase (ChA) and didn't influence the acetyl- and butyrilcholinesterase activity and acetylcholine (Ach) content in the mouse brain. NVP (25 mg/kg) failed to influence the ChA activity. Pretreatment with NVP (25 and 250 mg/kg) increased the duration of hexenal sleep in mice greatly, and a dose of 250 mg/kg (but not of 25 mg/kg) enhanced the atropine activity in mice poisoned with armine. NVP (250 mg/kg) reduced the release of Ach from the cerebral cortex of a cat, spontaneous and evoked by atropine and electrical stimulation of the reticular formation of the brain stem. A conclusion was drawn that the pharmacological effect of NVP when the latter was applied in combination with atropine and armine could be connected with the anti-Cha action and the inhibition of the newly-formed Ach, rather than with depression of the microsomal enzymes.
D000109:Acetylcholine / Q000378:metabolism; D000110:Acetylcholinesterase / Q000378:metabolism; D000123:Acetyltransferases / Q000037:antagonists & inhibitors*; D000818:Animals; D000931:Antidotes / Q000627:therapeutic use; D001285:Atropine / Q000627:therapeutic use; D001921:Brain / Q000187:drug effects* / Q000201:enzymology / Q000378:metabolism; D002091:Butyrylcholinesterase / Q000378:metabolism; D002415:Cats; D002795:Choline O-Acetyltransferase / Q000037:antagonists & inhibitors*; D004357:Drug Synergism; D006591:Hexobarbital / Q000494:pharmacology; D007928:Lethal Dose 50; D008297:Male; D051379:Mice; D008916:Miotics / Q000506:poisoning; D009286:Naphthylvinylpyridine / Q000494:pharmacology* / Q000627:therapeutic use; D062025:Organophosphate Poisoning; D011725:Pyridines / Q000494:pharmacology*; D012890:Sleep / Q000187:drug effects
D000931:Antidotes; D008916:Miotics; D011725:Pyridines; D009286:Naphthylvinylpyridine; D001285:Atropine; D006591:Hexobarbital; D000123:Acetyltransferases; D002795:Choline O-Acetyltransferase; D000110:Acetylcholinesterase; D002091:Butyrylcholinesterase; D000109:Acetylcholine
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