Effects of synthetic single- and multistranded polynucleotides on human monocyte IgG receptor activity in vitro.
Human peripheral monocytes demonstrated a higher IgG receptor activity in vitro after incubation with multistranded polynucleotides (poly(I:C) and poly(I:C:U)) after 6-hr cultivation periods. These changes were most pronounced using SRBC coated with low anti-Forssman antibody concentrations (EA, 1:1600 and 1:6400). Polyinosinic and polycytidylic acids failed to show changes in receptor activity. These findings suggest monocyte activation in vitro by multistranded polynucleotides and may in part explain their antitumor activity.
D002462:Cell Membrane / Q000187:drug effects; D006801:Humans; D007074:Immunoglobulin G / Q000378:metabolism*; D009000:Monocytes / Q000187:drug effects / Q000276:immunology* / Q000648:ultrastructure; D009690:Nucleic Acid Conformation; D011066:Poly C / Q000494:pharmacology; D011069:Poly I / Q000494:pharmacology; D011070:Poly I-C / Q000494:pharmacology; D011131:Polyribonucleotides / Q000494:pharmacology*; D011955:Receptors, Drug / Q000187:drug effects*; D013329:Structure-Activity Relationship
D007074:Immunoglobulin G; D011131:Polyribonucleotides; D011955:Receptors, Drug; D011069:Poly I; D011066:Poly C; D011070:Poly I-C