Chromosome rearrangements from spermatogonial chronic neutron irradiation in mice.
Adult male mice were given a range of neutron doses at 80 +/- 20 mrad/h from a plutonium-beryllium source. Cytogenetic analysis indicated that chronic spermatogonial exposure to a mean total dose of 10, 30, 52, 98 or 150 rad produced translocations, sampled in spermatocytes four months later, amounting to 0.32, 0.99. 1.69, 1.91 and 1.65%, respectively. The dose response for the 0-52 rad range was linear. For higher doses, a better fit to the data was an expression with dose exponent above unity.
D000818:Animals; D002869:Chromosome Aberrations; D004307:Dose-Response Relationship, Radiation; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D009502:Neutrons; D011831:Radiation Genetics; D013093:Spermatogonia / Q000528:radiation effects*; D013094:Spermatozoa / Q000528:radiation effects*