Metabolism of oestradiol-17beta by intestinal bacteria in rats.
In vitro experiments were carried out in which [4-14C]oestradiol-17beta was incubated with a culture from caecal content from adult male rats at 37 degrees C in an atmosphere of nitrogen. Oestrone was identified as the only certain metabolite. Other metabolites, if present, were quantitatively unimportant. The conversion of oestradiol-17beta to oestrone was estimated to be 22-42%.
D000818:Animals; D002432:Cecum / Q000382:microbiology*; D002850:Chromatography, Gel; D004958:Estradiol / Q000378:metabolism*; D004970:Estrone / Q000378:metabolism; D008297:Male; D051381:Rats
D004970:Estrone; D004958:Estradiol