[Pathomorphology of the vascular bed of the lungs and pleura in the presence of hypervolemia of the pulmonary circulation].
Blood and lymphatic vessels of the lungs and the pleura in 23 infants aged below one year, who had died of congenital cardiac defects with hypervolemia of the lesser circulation (coarctation of the aorta, transposition of the major vessels, general arterial trunk in combination with septal defects, open arterial canal and other anomalies) and in 5 dogs with artificial anastomosis of Blalock (3), Cooley (I) and Pootts (I) were studied; In treatment of the materials various histological and histochemical methods, micropreparation and impregnation of total preparation according to Ranvier's and V. V; Kupriyanov's techniques were used. The results obtained showed that an excessive blood content of the lesser circulation was accompanied by onset in the vessels of the lungs and the pleura of various accomodative changes, which were particularly pronounced in the system of microcirculation. It was established that functional insufficiency of the adaptive mechanisms led to the "breakdown" of compensation, impairment of blood and lymph circulation in the terminal vascular bed of the lungs and to grave secondary alterations in the organ. It was shown that early correction of hypervolemia of the lesser circulation in the experiment brought about normalization of hemodynamics in the lungs and more or less full recovery of the structure of microvessels of the regional bed.
D002648:Child; D006330:Heart Defects, Congenital / Q000150:complications*; D006801:Humans; D008168:Lung / Q000098:blood supply; D008171:Lung Diseases / Q000209:etiology / Q000473:pathology*; D008208:Lymphatic System / Q000473:pathology*; D008833:Microcirculation / Q000473:pathology*; D010994:Pleura / Q000098:blood supply; D010995:Pleural Diseases / Q000209:etiology / Q000473:pathology*
Patomorfologiia sosudistogo rusla legkikh i plevry pri gipervolemii malogo kruga krovoobrashcheniia