"Second generation" prostaglandins: midtrimester pregnancy termination by intramuscular injection of a 15-methyl analog of prostaglandin F2alpha.
Eighty midtrimester gravid patients were treated with prostaglandin 15(S)-15-methyl Fa alpha by repeated intramuscular injections of 250 mug at 2-hour intervals for the elective termination of pregnancy. A success rate of 97.5% was achieved, with a mean initiation-to-abortion time of 17.2 +/- 1.0 hours. Gastrointestinal side effects were prominent but no serious complications occurred. Serial serum progesterone determinations and continuous intra-amniotic pressure recording were carried out in selected cases and correlated with abortifacient activity. This method of pregnancy termination appears particularly suitable for use in the early midtrimester of gestation.
D000028:Abortion, Induced; D000293:Adolescent; D000328:Adult; D005260:Female; D006801:Humans; D007273:Injections, Intramuscular; D011247:Pregnancy; D011262:Pregnancy Trimester, Second; D011374:Progesterone / Q000097:blood; D011460:Prostaglandins F / Q000008:administration & dosage* / Q000009:adverse effects; D013997:Time Factors
D011460:Prostaglandins F; D011374:Progesterone