[Oxidative phosphorylation, catecholamine content and contractile function of the myocardium in patients with acquired heart defects, operated on under artificial circulation].
A simultaneous determination of oxidative phosphorylation, catecholamines content and contractile function of the myocardium was conducted in patients with acquired heart diseases operated under extracorporeal circulation. The degree of conjugation of the oxidative phosphorylation has been found to depend on the severity of the initial state of the patient, and on the conditions of the surgical intervention: duration of cardiopulmonary by-pass before the excision of the mitral valve, duration of cross-clamping of the aorta, and the temperature regiment of the perfusion. Besides, it has been found that the conjugated oxidative phosphorylation is associated with the presence of catecholamines in the myocardium, while the dissociation of these processes is accompanied by a sharp fall in the content of adrenalin, noradrenalin and dophamine. The established parallelism of the catecholamines content and the oxidative phosphorylation indicates the existing correlation between them, which may determine the character of the contractile function of the myocardium.
D000255:Adenosine Triphosphate / Q000096:biosynthesis; D000293:Adolescent; D000328:Adult; D002395:Catecholamines / Q000378:metabolism*; D002648:Child; D005112:Extracorporeal Circulation; D006349:Heart Valve Diseases / Q000503:physiopathology* / Q000601:surgery; D006350:Heart Valve Prosthesis; D006801:Humans; D008875:Middle Aged; D008931:Mitochondria, Muscle / Q000378:metabolism; D009200:Myocardial Contraction; D009206:Myocardium / Q000378:metabolism* / Q000473:pathology; D010085:Oxidative Phosphorylation; D012214:Rheumatic Heart Disease / Q000503:physiopathology* / Q000601:surgery
D002395:Catecholamines; D000255:Adenosine Triphosphate
Okislitel'noe fosforilirovanie, soderzhanie katekholaminov, i sokratitel'naia funktsiia miokarda u bol'nykh priobretennymi porokami serdtsa, operirovannykh v usloviiakh iskusstvennogo krovoobrashcheniia