[Effect of tranquilizers (diazepam and chlordiazepoxide) on the blood supply and activity of the heart].
The effect of diazepam (0.15 and 0.5 mg/kg) and chlordiazepoxide (1.0 and 2.0 mg/kg) on the blood supply and cardiac action were investigated in experiments on cats anesthetized with urethan and chlorasol. Both these compounds were found to lower the vascular resistance to  the blood flow, to bring down the coronary circulation rate and the oxygen intake of the heart. The preparations exert a marked influence on the work of the heart and the state of hemodynamics. Diazepam causes the development of an appreciable hypertension, bradycardia and reduces the cardiac ejection. Chlordiazepoxide produces a less pronounced fall of the arterial pressure, bradycardia and reduced the cardiac ejection. Unlike chlordiazepoxide diapezam reduces the contractibility of the myocardium, this being manifested in lessening the maximum acceleration of the blood flow in the aorta and in an increase of the systolic contraction time. Inhibition of the myocardium contractility occurring under the influence of diazepam may, to a certain degree, explain more pronounced hypotension observable on administration of this preparation.
D000818:Animals; D002415:Cats; D002707:Chlordiazepoxide / Q000494:pharmacology*; D003326:Coronary Circulation / Q000187:drug effects; D003331:Coronary Vessels / Q000187:drug effects*; D003975:Diazepam / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D006321:Heart / Q000187:drug effects*; D006339:Heart Rate / Q000187:drug effects; D006439:Hemodynamics / Q000187:drug effects; D009200:Myocardial Contraction / Q000187:drug effects; D010101:Oxygen Consumption / Q000187:drug effects; D012077:Renal Artery / Q000187:drug effects; D012082:Renal Veins / Q000187:drug effects; D013997:Time Factors; D014655:Vascular Resistance / Q000187:drug effects
D002707:Chlordiazepoxide; D003975:Diazepam
Vliianie trankvilizatorov (diazepama i khlordiazepoksida) na krovosnabzhenie i deiatel'nost' serdtsa