title: Effects of some water-soluble contrast media on the colonic mucosa.
abstract: Enemas of various solutions were administered to rats to determine if Gastrografin was specifically irritating to the colonic mucosa. Gastrografin was found to cause considerably more inflammation than Hypaque-25, or barium sulfate. Further studies with hypertonic sorbitol, Renografin-76, and Tween 80 suggested that (a) neither hyperosmolality nor the diatrizoate compound itself were damaging to the colon, and (b) Tween 80 most likely plays a major role in Gastrografin's inflammatory effect.
mesh_terms: D000818:Animals; D001466:Barium Sulfate / Q000009:adverse effects; D003106:Colon / Q000187:drug effects*; D003287:Contrast Media / Q000009:adverse effects*; D003973:Diatrizoate / Q000009:adverse effects; D003974:Diatrizoate Meglumine / Q000009:adverse effects; D007413:Intestinal Mucosa / Q000187:drug effects*; D009336:Necrosis; D051381:Rats; D012462:Saline Solution, Hypertonic; D012995:Solubility; D013012:Sorbitol / Q000009:adverse effects; D014867:Water
chemical_list: D003287:Contrast Media; D012462:Saline Solution, Hypertonic; D014867:Water; D003973:Diatrizoate; D001466:Barium Sulfate; D003974:Diatrizoate Meglumine; D013012:Sorbitol