title: Blood platelet aggregation and personality traits.
abstract: Changes in blood platelet aggregation may precipitate episodes of arterial occlusive diseases. Little is known, however, regarding the influence of psychological traits, emotional states and other behavioral stressors on platelet aggregation phenomena. This study examined 46 healthy college men at rest and after submaximal treadmill exercise. Associations were found between the duration of platelet aggregation and a number of scores from the California Psychological Inventory and self-administered anxiety scales. The more socially adequate, poised and dominant persons--those with more mature ego development and less overt anxiety--had platelets with more prolonged aggregation reactions to the in vitro introduction of noradrenalin. Irreversible aggregation of platelets occurred more regularly to lower in vitro concentrations of noradrenalin in platelet samples drawn from subjects who were less anxious and tended to be more rigidly defensive. It is premature to attempt to derive clinical implications from this exploratory work, but some implications for the design of future research are discussed.
mesh_terms: D000328:Adult; D001007:Anxiety / Q000175:diagnosis; D004837:Epinephrine / Q000494:pharmacology; D006801:Humans; D008297:Male; D009638:Norepinephrine / Q000494:pharmacology; D010551:Personality; D005082:Physical Exertion; D010974:Platelet Aggregation / Q000187:drug effects; D013997:Time Factors
chemical_list: D009638:Norepinephrine; D004837:Epinephrine