Measurement of extracellular fluid after acute myocardial infarction.
The volume of distribution of [60Co]EDTA in normal dog myocardium is slightly less than that calculated from tissue contents of H2O, Cl, K, and their extracellular fluid (ECF) concentrations subsuming a steady state across cell membranes. The volume of distribution of [3H-]sorbitol was substantially higher than the measured CoEDTA space. [60Co]EDTA can be measured in ischemic myocardium that remains perfused. Extraction of [60Co]EDTA and [3H-]sorbitol is incomplete from dried biopsies.
D000818:Animals; D001834:Body Water / Q000378:metabolism; D002462:Cell Membrane / Q000378:metabolism; D002712:Chlorides / Q000378:metabolism; D003035:Cobalt / Q000378:metabolism; D004285:Dogs; D005110:Extracellular Space / Q000378:metabolism / Q000502:physiology*; D009203:Myocardial Infarction / Q000503:physiopathology*; D009206:Myocardium / Q000378:metabolism; D011188:Potassium / Q000378:metabolism
D002712:Chlorides; D003035:Cobalt; D011188:Potassium