title: Probe for production and measurement of acute mitral regurgitant flow in dog.
abstract: A probe for production and measurement of acute mitral regurgitation in dogs is described. It consists of a tube that is introduced into the mitral valve through the left atrial appendage. Regurgitant flow through the tube is measured by an electromagnetic device. Variation of flow and zero flow are achieved by narrowing or occluding the tube with a rubber cuff. In animals weighing 30-50 kg, the probe does not produce significant mitral stenosis and the mitral leaflets fit closely around the probe during ventricular systole. The instantaneous relationship between mitral regurgitant flow (MRF) and the gradient between left ventricular and left atrial pressure shows a marked delay of MRF at the beginning and end of regurgitation. This delay can be attributed to some extent to electrical phase lag and to the small movement of the probe relative to the mitral valve during the cardiac cycle. Measurement of regurgitant stroke volume is affected by this movement only to a small extent.
mesh_terms: D000818:Animals; D002302:Cardiac Output; D003326:Coronary Circulation; D004285:Dogs; D006334:Heart Function Tests / Q000295:instrumentation*; D008943:Mitral Valve / Q000502:physiology*; D009200:Myocardial Contraction; D012039:Regional Blood Flow