The age-dependent efficacy of polyadenylic-polyuridylic acid therapy upon the development of spontaneous leukemia in AKR mice.
The synthetic double-stranded polynucleotide, polyadenylic-polyuridylic acid, has been shown to increase the long-term survival of AKR mice. In order to determine whether this effect was age dependent, polyadenylic-polyuridylic acid was administered to AKR mice starting at 2, 4, 6, or 8 months of age. The best therapeutic effect was achieved when polyadenylic-polyuridylic acid treatments were begun at 2 months of age, and there was no beneficial effect when begun at 8 months of age.
D000367:Age Factors; D000818:Animals; D005260:Female; D007945:Leukemia, Lymphoid / Q000188:drug therapy*; D051379:Mice; D011063:Poly A-U / Q000627:therapeutic use*
D011063:Poly A-U