Electrophysiological and behavioral effects of 1-methyl-5-(o-fluorophenyl)-7-chloro-1,3-dihydro-2H-1,4-benzodiazepin-2-one (ID-540) in cats and rabbits.
Effects of ID-540 (1-methyl-5-(o-fluorophenyl)-7-chloro-1,3-dihydro-2H-1,4-benzodiazepin-2-one) on the central nervous system were evaluated electrophysiologically and behaviorally in cats and rabbits. The reference compound used was diazepam. 1. ID-540 as well as diazepam produced muscle relaxation, grooming, facilitation of appetite and suppression of defensive behaviors. ID-540 made the animals lie on their side during sleep, but diazepam did not. 2. Though more effectively inducing an increase in fast activity and a decrease in frequency of hippocampal theta-waves than diazepam, ID-540 scarcely affected the amplitude of subcortical EEG (hippocampus, amygdala and hypothalamus), which diazepam decreased in cats. 3. ID-540 and diazepam increased the waking phase and decreased the paradoxical sleep phase. 4. ID-540 and diazepam at a dose of 1 mg/kg decreased the duration of amygdala after-discharge for 1 h in cats. Diazepam increased the duration of the after-discharge after it had been decreased, but ID-540 did not. ID-540 did not affect the duration of hippocampal after-discharge whereas diazepam prolonged it. 5. ID-540 depressed more effectively the hippocampal arousal response to stimulation of the ventro-medial hypothalamus than did diazepam in rabbits. 6. ID-540 depressed amygdalo-hippocampal evoked potential in cats. 7. ID-540 did not affect norepinephrine-induced pressor response but reduced hypothalamic pressor response in cats.
D000818:Animals; D001143:Arousal / Q000187:drug effects; D001522:Behavior, Animal / Q000187:drug effects*; D001570:Benzodiazepinones / Q000494:pharmacology*; D001794:Blood Pressure / Q000187:drug effects; D002415:Cats; D003975:Diazepam / Q000494:pharmacology; D004558:Electric Stimulation; D004567:Electrodes, Implanted; D004569:Electroencephalography; D005071:Evoked Potentials / Q000187:drug effects; D007031:Hypothalamus / Q000502:physiology; D009638:Norepinephrine / Q000494:pharmacology; D011817:Rabbits; D012890:Sleep / Q000187:drug effects
D001570:Benzodiazepinones; D003975:Diazepam; D009638:Norepinephrine