Amplification of the bradykinin response in rat uterus by pCMB-Dextran T 10.
pCMB-Dextran T 10,a large, non-penetrating SH-blocking reagent caused a reversible amplification of bradykinin sensituvity in the isolated rat uterus. High concentrations of this compound (1 x 10-3 M) can evoke spontaneous uterus contraction. pCMB-Dextran T 10 did not alter the biological activity of bradykinin. It is assumed that superficial membrane SH-groups are involved in the uterus contraction mechanism.
D000818:Animals; D001920:Bradykinin / Q000494:pharmacology*; D002729:Chloromercuribenzoates / Q000494:pharmacology*; D003911:Dextrans / Q000031:analogs & derivatives / Q000494:pharmacology; D004357:Drug Synergism; D005260:Female; D066298:In Vitro Techniques; D051381:Rats; D013439:Sulfhydryl Reagents / Q000494:pharmacology*; D014590:Uterine Contraction / Q000187:drug effects*
D002729:Chloromercuribenzoates; D003911:Dextrans; D013439:Sulfhydryl Reagents; C017138:CMB-dextran; D001920:Bradykinin