[Effect of phenamine and gutimine and gutimine on adaptive changes in arterial pressure occurring during skeletal muscle contraction].
Effects of amphetamine (0,1--11 mg/kg) and gutimin (5--50 mg/kg) on the pressor reflex originating in the exercising muscle were studied on nonanesthetized decerebrate cats. Isometric exercise of the hind limb muscles was elicited by stimulating the spinal ventral roots L6--S1. Amphetamine (0.1 mg/kg) increased the level of arterial pressure and the amplitude of the pressor reflex. Higher doses of amphetamine decreased the pressor reflex to exercises and there was a fall of arterial pressure. Gutimin elevated the arterial pressure and failed to alter the pressor reflex to exercises.
D000661:Amphetamine / Q000494:pharmacology*; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects*; D002415:Cats; D004305:Dose-Response Relationship, Drug; D009119:Muscle Contraction; D012018:Reflex / Q000187:drug effects*; D013890:Thiourea / Q000031:analogs & derivatives* / Q000494:pharmacology
D000661:Amphetamine; D013890:Thiourea
Vliianie fenamina i gutimina na adaptatsionnye izmeneniia arterial'nogo devleniia, voznikaiushchie pri sokrashchenii skeletnykh myshts