[Effects of nialamide on brain monoamine consumption and liver glycogen content in rats chronically treated with insulin].
Male rats weighing about 50 g were fed a normal-balanced diet for 100 days during which time i.p. injections of saline solution (2 ml/kg) or insulin (4 IU/kg) and/or nialamide (30 mg/kg) were given every two days. The animals were sacrificed 16 hr after the last injection and the brains and livers were extracted for the measurement of tyramine consumption and liver glycogen deposition. It was found that the decrease of glycogen deposition and tyramine consumption induced by nialamide was inhibited by a simultaneous administration of insulin.
D000818:Animals; D001679:Biogenic Amines / Q000378:metabolism*; D001921:Brain / Q000378:metabolism*; D007328:Insulin / Q000008:administration & dosage* / Q000494:pharmacology; D008112:Liver Glycogen / Q000378:metabolism*; D008297:Male; D009526:Nialamide / Q000494:pharmacology*; D051381:Rats; D013997:Time Factors
D001679:Biogenic Amines; D007328:Insulin; D008112:Liver Glycogen; D009526:Nialamide