99mTc-diphosphonate uptake in skeletal muscle: a quantitative index of acute damage.
In rats with ischemic myopathy induced by aortic ligation and 5-hydroxytryptamine, there was good correlation of the skeletal muscle concentration of 99mTc-diphosphonate with the increase of plasma creatine phosphokinase and the decrease in muscle potassium. This radionuclide tracer method can be used to quantitate acute injury in individual muscles and provides a basis for clinical nuclear imaging in patients with a variety of disorders involving muscle fiber damage.
D000208:Acute Disease; D000818:Animals; D007511:Ischemia / Q000378:metabolism*; D008297:Male; D009132:Muscles / Q000098:blood supply* / Q000378:metabolism; D063065:Organophosphonates / Q000378:metabolism*; D011188:Potassium / Q000378:metabolism; D051381:Rats; D013667:Technetium
D063065:Organophosphonates; D013667:Technetium; D011188:Potassium