[Participation of the lung in capturing subcutaneously injected antigens].
Experiments were conducted on guinea pigs. With the aid of fluorescein-labeled antibodies it was shown that following a single or a two-fold immunization into the footpad complete typhoid antigen was revealed in the lung macrophages as soon as the first days (or after a two-fold administration-in several hours) and persisted there for 30 days. There was a tendency to concentration of the antigen-containing macrophages in the perivascular and the peribronchial tissues. The dynamics of the antigen spread along the lymphoid organs is also described.
D000818:Animals; D000942:Antigens, Bacterial / Q000008:administration & dosage*; D006168:Guinea Pigs; D007114:Immunization; D007117:Immunization, Secondary; D007279:Injections, Subcutaneous; D008168:Lung / Q000276:immunology*; D008264:Macrophages / Q000276:immunology; D012485:Salmonella typhi / Q000276:immunology*; D013154:Spleen / Q000276:immunology
D000942:Antigens, Bacterial
Ob uchastii legkikh v zakhvate antigena pri podkozhnom vvedenii ego