[Effect of promedol and fentanyl on the permeability of the hemato-encephalic barrier of rats for noradrenaline-H3].
In tests situations with rats it was shown that promedol and phentanide produce an analgetic action accompanied by a reduced flow of tagged norepinephrine from the blood into the brain. A parallelism between the dosage of the substances and the intensity of the analgetic effect and the degree of changed permeability of the blood-cerebral barrier could be noted.
D000818:Animals; D001812:Blood-Brain Barrier / Q000187:drug effects*; D003864:Depression, Chemical; D004305:Dose-Response Relationship, Drug; D004347:Drug Interactions; D005283:Fentanyl / Q000494:pharmacology*; D008297:Male; D008614:Meperidine / Q000031:analogs & derivatives*; D009638:Norepinephrine / Q000494:pharmacology*; D010539:Permeability; D051381:Rats; D013997:Time Factors; D014316:Tritium
D014316:Tritium; D008614:Meperidine; D005283:Fentanyl; D009638:Norepinephrine
Vliianie promedola i fentanila na pronitsaemost' gematoéntsefalicheskogo bar'era krys dlia noradrenalina-H3