[Effect of amphotericin B and its combination with 5-fluorouracil on the development of transplantable rat lymphosarcoma].
The studies were carried out on rats with subcutaneously transplanted metastizing Pliss lymphosarcoma. The animals were treated with amphotericin B administered intravenously in complex with sodium desoxycholate in doses of 336 and 20 Units/kg for 7 days beginning from 24th hour after the tumor transplantation. The treatment resulted in a statistically reliable inhibition of the tumor metastasizing as compared to the control animals. When the animals with the tumors were subjected to combined therapy with 5-fluoruracyl and amphotericin B, the antitumor and antimetastatic effect of 5-fluoruracyl significantly increased. Determination of amphotericin B binding with the organ homogenates showed that the antibiotic bound with the homogenates or the organs of the rats with the tumors to a greater extent than with those of the intact animals. The levels of the antibiotics in the tumor metastases were higher than those in the primary tumors.
D000666:Amphotericin B / Q000032:analysis / Q000494:pharmacology*; D000818:Animals; D004357:Drug Synergism; D004359:Drug Therapy, Combination; D005260:Female; D005472:Fluorouracil / Q000494:pharmacology*; D008207:Lymphatic Metastasis; D008228:Lymphoma, Non-Hodgkin / Q000032:analysis / Q000188:drug therapy*; D009368:Neoplasm Transplantation; D009374:Neoplasms, Experimental / Q000032:analysis / Q000188:drug therapy; D051381:Rats
D000666:Amphotericin B; D005472:Fluorouracil
O vliianii amfoteritsina B i ego sochetaniia s 5-ftoruratsilom na razvitie perevivaemoĭ limfosarkomy krys