Fixation of the first component of complement by immune complexes: effect of reduction and fragmentation of antibody.
The integrity of both covalent and non-covalent bonds between the heavy chains of rabbit immunoglobulin gamma antibody is essential for maximal efficiency of binding of the first component of complement to immune complexes.
D000818:Animals; D000906:Antibodies; D000937:Antigen-Antibody Reactions; D003172:Complement C1; D003165:Complement System Proteins; D006168:Guinea Pigs / Q000276:immunology; D007140:Immunoglobulin Fab Fragments; D007141:Immunoglobulin Fc Fragments; D007074:Immunoglobulin G; D011485:Protein Binding; D011817:Rabbits / Q000276:immunology
D000906:Antibodies; D003172:Complement C1; D007140:Immunoglobulin Fab Fragments; D007141:Immunoglobulin Fc Fragments; D007074:Immunoglobulin G; D003165:Complement System Proteins