title: Role of gastrin determinations in clinical surgery.
abstract: Patients with recurrent ulcer without retained antrum and with a complete vagotomy will have a low gastric acid output. Those with incomplete vagotomy and gastric resection will have a fasting and histamine-stimulated gastric acid output which are normal' this is as though they had no previous gastric operation. Both groups of patients will have a normal fasting and postprandial serum gastrin. Patients with recurrent ulcer associated with retained antrum will have a fasting and histamine-stimulated acid output above normal. In the latter, fasting serum gastrin will be increased twice normal but not as markedly increased as found in Zollinger-Ellison syndrome. Patients with retained antrum will have a marked postprandial increase in serum gastrin about two times the fasting level. Those patients with this syndrome will have markedly elevated fasting and histamine-stimulated gastric acid as well as marked hypergastrinemia.
mesh_terms: D005745:Gastric Acidity Determination; D005755:Gastrins / Q000097:blood*; D006801:Humans; D010437:Peptic Ulcer / Q000097:blood / Q000601:surgery*; D011446:Prospective Studies; D012008:Recurrence; D013514:Surgical Procedures, Operative
chemical_list: D005755:Gastrins