[The diagnostic and prognostic significance of epithelial blood group isoantigens in carcinomas and polyps of the colon (author's transl)].
Blood group isoantigens (BG) were detected in carcinomas and polyps of the colon and were related to the degree of differentiation, the histologic type, the age of the patients and the histologic signs of malignancy. 1. BG were found in 60-70% of colon carcinomas regardless of their differentiation. 2. BG-positive carcinomas were less often surrounded by lymphocytes and plasma cells than BG-negative ones. 3. BG were present in colon polyps as mucusassociated and as membrane-associated antigens depending on the differentiation of the cells. Hence, BG-activity can be regarded as additional criterium to assess objectively the differentiation of the tumor cells in a polyp. 4. The percentage of BG-positive polyps increased with dedifferentiation. 5. Polyps with foci of malignant degeneration were consistently BG-positive. 6. Villous polyps contained BG more often than the adenomatous ones. 7. The results support the concept that both villous and adenomatous polyps of the colon are precancerous lesions.
D001789:Blood Group Antigens; D002471:Cell Transformation, Neoplastic; D003110:Colonic Neoplasms / Q000175:diagnosis* / Q000276:immunology; D006801:Humans; D007417:Intestinal Polyps / Q000175:diagnosis* / Q000276:immunology; D007519:Isoantigens
D001789:Blood Group Antigens; D007519:Isoantigens
Untersuchungen zur diagnostischen und prognostischen Bedeutung Epithel-gebundener Blutgruppenisoantigene in Karzinomen und Polypen des Dickdarmes