[Prospidin-C14 blood level, distribution in the organs and tissues and excretion from the body of rats].
Experiments were conducted on rats with sarcoma-45 and intact ones to study the prospidin-C14 content in the blood, distribution of the drug among the organs and tissues and its elimination from the organism. A single intravenous introduction of prospidin-C14 was found to be followed by its quick (in 2 hours) disappearance frob the blood. During the first 15 minutes the distribution of the drug over the organs and tissues was of a non-uniform nature and different from the distribution of other known antineoplastic agents, with relatively high concentrations of prospidin-C14 being demonstrable in the kidneys, lungs, the skin, intestine, bones, pancreas and low ones--in the liver, spleen and lymph nodes. The elimination of the drug from the organs and tissues is non-uniform. Prospidin-C14 and labeled products of its transformation are quickly (during the first 24 hours after administration) passed from the organism, chiefly with urine.
D000818:Animals; D002250:Carbon Radioisotopes; D005243:Feces / Q000032:analysis; D007275:Injections, Intravenous; D007700:Kinetics; D008297:Male; D009368:Neoplasm Transplantation; D010879:Piperazines / Q000378:metabolism*; D011447:Prospidium / Q000378:metabolism* / Q000652:urine; D011851:Radioactivity; D051381:Rats; D012513:Sarcoma, Experimental / Q000188:drug therapy / Q000378:metabolism; D013997:Time Factors
D002250:Carbon Radioisotopes; D010879:Piperazines; D011447:Prospidium
O soderzhanii v krovi, raspredelenii po organam i tkaniam i vyvedenii iz organizma krys prospidina-C14