H3-p-chloroamphetamine: cerebral levels and distribution.
Whole-brain levels of radioactivity were assessed at 0,2,6,12, or 24 hours, 1 1/2,2,7,10, and 14 days after intraventricular injection of H3 -p-CA. Urinary excretion and peripheral distribution were also followed for one week. The rate of elimination of total radioactivity from brain is biphasic with a T 1/2 of 1.2 hours and 2.5 days after intraventricular and 4.2 hours and 1.9 days after intraperitoneal injection of p-CA. The distribution into cerebellum, neocortex, brainstem, and telencephalon was studied at 1 hour, 2,3,5, and 7 days after injection. At both three and seven days, the radioactivity is still present in all the areas of the brain. The contribution of H3-p-CA to total radioactivity in the toluene extractable fraction was measured. By twelve hours, four chromatographically distinct peaks of radioactivity can be isolated from the toluene extract. The radiolabel in the subcellular fractions was also determined. There is a significant shift of radiolabel from the supernatant to organelle-bound phases between three and seven days.
D000662:Amphetamines / Q000378:metabolism*; D000818:Animals; D001921:Brain / Q000648:ultrastructure; D001923:Brain Chemistry; D007274:Injections, Intraperitoneal; D007276:Injections, Intraventricular; D007700:Kinetics; D008297:Male; D051381:Rats; D013997:Time Factors; D010133:p-Chloroamphetamine / Q000008:administration & dosage / Q000032:analysis / Q000378:metabolism*
D000662:Amphetamines; D010133:p-Chloroamphetamine