[On the mode of action of heterologous antileukemic sera. Growth of syngeneically transplanted leukemia cells on serum treated neonatally thymectomized mice (author's transl)].
A heterologous antiserum against a Nitrosomethylurea--induced mouse leukemia prevented the outgrowth of syngeneically transplanted leukemia cells in neonatally thymectomized mice. After subcutaneous challenge with 50 000 leukemia-ascites cells thymectomized CBA mice at the age of 8 weeks were given 5 intraperitoneal injections each of 0,1 ml of the heterologous serum. While the antileukemic serum protected 9 out of 11 mice all of the 11 mice treated with normal rabbit serum developed a tumor. The absence of the thymus was confirmed by macroscopic control and by the absence of antibodies against the injected rabbit serum. With regard to previous findings showing a cooperation of heterologous antibodies with host cells as responsible for the antileukemic effect this result indicates that the effector cells are thymus-independent.
D000818:Animals; D000831:Animals, Newborn; D000918:Antibody Specificity; D007106:Immune Sera / Q000494:pharmacology*; D007938:Leukemia / Q000276:immunology* / Q000517:prevention & control; D007942:Leukemia, Experimental; D008770:Methylnitrosourea; D051379:Mice; D008808:Mice, Inbred CBA; D013934:Thymectomy; D013950:Thymus Gland / Q000276:immunology
D007106:Immune Sera; D008770:Methylnitrosourea
Zum Wirkungsmechnismus heterologer antileukämischer Sera. 2. Wachstrum syngen transplantierter Leukämiezellen in serum-behandelten, neonatal thymektomierten Mäusen