[Effect of N-nitroso compounds and aminoazo compound on organ cultures of human embryonal kidney].
It was shown that embryonal tissue of human kidney could be explanted into organ cultures during 3-4 weeks. In the immediate effect of N-methyl nitrosurea (NMU), dimethyl nitrosamine (DMNA) and orthoamino-azotoluole (OAAT) a considerable number of hyperplastic epithelial growths was revealed, various types of morphological changes: tubular epithelium hyperplasia, glomerular epithelium hyperplasia and mixed hyperplasia (simultaneous hyperplasia in tubular and glomerular epithelium) being noted. Their frequency increased as the experiment proceeded, and also was dependent on the carcinogen concentration in a nutrient medium. NMU mostly produced a hyperplastic growth in tubular epithelium, DMNA--in glomerular epithelium while OAAT resulted in enhancement of hyperplastic processes in tubular and glomerular epithelium.
D001391:Azo Compounds / Q000494:pharmacology*; D002478:Cells, Cultured / Q000187:drug effects; D004128:Dimethylnitrosamine / Q000494:pharmacology*; D004847:Epithelial Cells; D004848:Epithelium / Q000187:drug effects; D005260:Female; D006801:Humans; D006965:Hyperplasia; D007668:Kidney / Q000187:drug effects*; D007678:Kidney Glomerulus / Q000187:drug effects; D007684:Kidney Tubules / Q000187:drug effects; D008770:Methylnitrosourea / Q000494:pharmacology*; D009602:Nitrosamines / Q000494:pharmacology*; D009607:Nitrosourea Compounds / Q000494:pharmacology*; D009924:Organ Culture Techniques; D011247:Pregnancy; D009762:o-Aminoazotoluene / Q000494:pharmacology*
D001391:Azo Compounds; D009602:Nitrosamines; D009607:Nitrosourea Compounds; D008770:Methylnitrosourea; D004128:Dimethylnitrosamine; D009762:o-Aminoazotoluene
Deĭstvie N-nitrozosoedineniĭ i aminoazosoedineniĭ na organnye kul'tury émbronal'noĭ pochki cheloveka