[Influence of iodine preparations and triiodothyronine on the histological structure of the thyroid gland in experimental goiter].
Histological changes in the thyroid gland of rats in experimental goiter caused by administration of 6-methylthiouracil during 9 months, as well as changes in the structure of these glands under the effect of diurnal ingestion with food of microiodine (iodized potassium 2 mg+iodine 0.2 mg per animal), diiodotyrosine (1.25 mg per animal) and triiodthyronine (5 mcg per animal) are described. As a result of the exposure to the above mentioned preparations, there were noted a decrease in the weight of the thyroid glands reduction in the number and size of microadenoms therein, a drop of the intensity of hyperplastic processes in the thyroid epithelium, and an increased proliferation of clear cells. The greatest effect was observed in the animals which received triiodothyronine: weight and histological structure of the glands in these animals was approximating the norm. There were revealed anaplastic changes in the microadenomas remained after the exposure to iodine preparations and triiodothyronine, and an increased proliferation of clear cells with formation of microadenoms out of them.
D000818:Animals; D004105:Diiodotyrosine / Q000627:therapeutic use*; D004341:Drug Evaluation; D006042:Goiter / Q000188:drug therapy* / Q000473:pathology; D007455:Iodine / Q000627:therapeutic use*; D008297:Male; D009929:Organ Size; D011188:Potassium / Q000627:therapeutic use; D051381:Rats; D013961:Thyroid Gland / Q000473:pathology; D014284:Triiodothyronine / Q000627:therapeutic use*
D014284:Triiodothyronine; D004105:Diiodotyrosine; D007455:Iodine; D011188:Potassium
Vliianie ĭodistykh preparatov i triĭodtironina na gistologicheskuiu strukturu shchitovidnoĭ zhelezy pri eksperimental'nom zobe