title: Centric fission of chromosome no. 4 in the mother of two patients with trisomy 4p.
abstract: Centric fission of chromosome No. 4 was found in the healthy mother of two children with trisomy 4p. The two telocentrics derived are stable and show no evidence of fusing again. The 2:3 ratio of unbalanced offsprings born to the proposita indicates that, contrary to the evidence emerging from studies in other species, the risk for the production of unbalanced gametes is high.
mesh_terms: D000328:Adult; D005075:Biological Evolution; D002869:Chromosome Aberrations; D002875:Chromosomes; D002905:Chromosomes, Human, 4-5; D005260:Female; D006570:Heterochromatin / Q000032:analysis; D006801:Humans; D007223:Infant; D010375:Pedigree; D014314:Trisomy
chemical_list: D006570:Heterochromatin