title: Importance of initial management of persons internally contaminated with radionuclides.
abstract: The first one to three hours following a radiation accident during which internal contamination occurs provide the best and perhaps the only opportunity for preventing uptake of radionuclides. By using chemical manipulation in the GI tract or by hastening the material through the body, absorption can be reduced. Once absorbed, uptake in specific tissues can often be prevented by blocking agents, isotopic dilution or chelating agents. In order to supply prompt treatment, the medical department must have a well-defined action plan based on knowledge of the plant or laboratory operations, the radionuclides used, and medications required.
mesh_terms: D002400:Cathartics / Q000627:therapeutic use; D002614:Chelating Agents / Q000627:therapeutic use; D006801:Humans; D007455:Iodine / Q000627:therapeutic use; D007457:Iodine Radioisotopes / Q000009:adverse effects; D007554:Isotopes / Q000627:therapeutic use; D004369:Pentetic Acid / Q000627:therapeutic use; D011005:Plutonium / Q000009:adverse effects; D011832:Radiation Injuries / Q000188:drug therapy*; D011868:Radioisotopes / Q000009:adverse effects*; D013997:Time Factors
chemical_list: D002400:Cathartics; D002614:Chelating Agents; D007457:Iodine Radioisotopes; D007554:Isotopes; D011868:Radioisotopes; D011005:Plutonium; D004369:Pentetic Acid; D007455:Iodine