Are there therapeutic indications of intravenous injection of calcium gluconate?
1. The action of i.v. injection of calcium gluconate on a) the release of catecholamines from the adrenals of cats and dogs, b) the adrenergic responses of circulation, nictitating membrane and spleen in cats, and c) the cardiac and circulatory response in dogs has been investigated. 2. Ca2+-effects mediated by release of catecholamines dominate in the cat, as do direct cardiac stimulating actions in the dog. 3. Ca2+-effects of therapeutic significance, if existent at all, could be assumed only with regard to an anti-anaphylactic effect of the catecholamines released by i.v. injected Ca2+.
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D002118:Calcium / Q000494:pharmacology*; D002302:Cardiac Output / Q000187:drug effects; D002415:Cats; D004285:Dogs; D004305:Dose-Response Relationship, Drug; D004837:Epinephrine / Q000378:metabolism / Q000494:pharmacology; D005260:Female; D005263:Femoral Artery; D005942:Gluconates / Q000494:pharmacology*; D007275:Injections, Intravenous; D008297:Male; D009119:Muscle Contraction / Q000187:drug effects; D009541:Nictitating Membrane / Q000187:drug effects; D009638:Norepinephrine / Q000378:metabolism / Q000494:pharmacology; D010646:Phentolamine / Q000494:pharmacology; D012039:Regional Blood Flow / Q000187:drug effects; D013015:Sotalol / Q000494:pharmacology; D013154:Spleen / Q000187:drug effects
D005942:Gluconates; D013015:Sotalol; D002118:Calcium; D009638:Norepinephrine; D004837:Epinephrine; D010646:Phentolamine