Cycloalkanones. 8. Hypocholesterolemic activity of long-chain ketones related to pentadecanone.
Aliphatic analogs of 2,8-dibenzylcyclooctanone which includes C15-C18 ketones have been investigated for hypocholesterolemic activity in rats. The position of the carbonyl group in the chain for maximum activity appears to be the 2 position. 2-Hexadecanone reduced serum cholesterol levels significantly without altering serum triglyceride levels. This drug was not estrogenic at effective doses which is in contrast to the cyclooctanones which possess this activity.
D000818:Animals; D000924:Anticholesteremic Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D001835:Body Weight / Q000187:drug effects; D002369:Castration; D002462:Cell Membrane / Q000187:drug effects; D002784:Cholesterol / Q000097:blood; D004247:DNA / Q000378:metabolism; D004435:Eating / Q000187:drug effects; D005260:Female; D007659:Ketones / Q000138:chemical synthesis* / Q000494:pharmacology; D050356:Lipid Metabolism; D008099:Liver / Q000378:metabolism / Q000648:ultrastructure; D008112:Liver Glycogen / Q000378:metabolism; D008247:Lysosomes / Q000187:drug effects; D008297:Male; D051379:Mice; D010053:Ovary / Q000502:physiology; D011506:Proteins / Q000378:metabolism; D012313:RNA / Q000378:metabolism; D051381:Rats; D014280:Triglycerides / Q000097:blood; D014599:Uterus / Q000187:drug effects
D000924:Anticholesteremic Agents; D007659:Ketones; D008112:Liver Glycogen; D011506:Proteins; D014280:Triglycerides; D012313:RNA; D004247:DNA; D002784:Cholesterol