[Value of the propranolol test in the differential diagnosis of repolarization disorders in the ECG].
The propranolol-test was inaugurated as a simple method for the differentiation, whether repolarisation disturbance in the ECG is based on an organic or a functional cause. In order to determine the value of this test, in this study ECG-strips were done at rest and under bicycle exercise before and after assessment of beta-adrenergic receptor blockade on 41 patients with organic heart disease (most of them with chronic ischaemic heart disease [CIHD]) and 20 patients which had no evidence of heart disease. 19 of 26 patients with heart disease and ST-segment changes already in the ECG at rest had a false positive propranolol-test. Ischaemic ECG-responses under exercise conditions were diminished by the beta-adrenergic receptor blockade, too. These results are in coincidence with findings that give evidence of considerable sympathetic component in the multifactorial origin of coronary insufficiency and of protective therapeutic efficiency of beta-adrenolytic substances. It is concluded that the propranolol-test brings no further information--at least with regard to CIHD--whether repolarisation changes in the ECG are organic or not.
D000328:Adult; D003327:Coronary Disease / Q000175:diagnosis*; D003937:Diagnosis, Differential; D004562:Electrocardiography; D005080:Exercise Test; D005260:Female; D006327:Heart Block / Q000175:diagnosis*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011433:Propranolol
D011433:Propranolol
Zur Wertigkeit des Propranololtestes bei der Differentialdiagnose von Repolarisationsstörungen im Ekg