The acute effects of oral (--)-tryptophan in human subjects.
1 The psychotropic effects of a single oral dose of (--)-tryptophan (5 g) in human volunteers were investigated using a series of physiological and psychological tests. 2 Self-ratings of mood showed increase in drowsiness but no euphoria was detected. 3 Severe initial nausea occurred and headache increased; other bodily symptoms were unaffected. 4 Trptophan caused increased activity in the slow wavebands of the EEG but did not alter the other physiological measures. 5 The levels of total and free tryptophan in the plasma increased 8 and 20 fold respectively to peak levels 2 h after ingestion.
D000284:Administration, Oral; D000328:Adult; D004569:Electroencephalography; D005260:Female; D006261:Headache / Q000139:chemically induced; D006801:Humans; D008297:Male; D009043:Motor Activity / Q000187:drug effects; D009325:Nausea / Q000139:chemically induced; D010919:Placebos; D011619:Psychotropic Drugs; D014364:Tryptophan / Q000008:administration & dosage / Q000009:adverse effects / Q000494:pharmacology*
D010919:Placebos; D011619:Psychotropic Drugs; D014364:Tryptophan