[Influence of glucocorticoid hormones on the pool and intracellular distribution of ubiquinone in the tissues of rats].
Experiments on the study of the effect of glucocorticoids on the content and intracellular distribution of oubichinon in the liver, heart and spleen were conducted. Hydrocortisone (2.5 and 5 mg/100 g) and cortisone (5 mg/100 g) was injected subcutaneously for 10 days. It was found that hydrocortisone in a dose of 2.5 and cortisone in a dose of 5 mg/100 g failed to influence the total level of oubichinon in the tissues under study. Administration of hydrocortisone in a dose of 5 mg per 100 g of weight was accompanied by an increase in the oubichinon concentration in the spleen. A study of the intracellular distribution of the coenzyme indicated an elevation of its content in the hyaloplasma and its reduction in the mitochondrial fraction. On the basis of the data obtained it could be supposed that glucocorticoid regulation of the oubichinon level was realized at the subcellular level. Possibly, glucocorticoids altered the membrane permeability for oubichinon causing its redistribution in the cell.
D000818:Animals; D003348:Cortisone / Q000494:pharmacology*; D006854:Hydrocortisone / Q000494:pharmacology*; D008099:Liver / Q000378:metabolism; D008297:Male; D008928:Mitochondria / Q000378:metabolism; D009206:Myocardium / Q000378:metabolism; D051381:Rats; D013154:Spleen / Q000378:metabolism; D014451:Ubiquinone / Q000378:metabolism*
D014451:Ubiquinone; D003348:Cortisone; D006854:Hydrocortisone
Vliianie gliukokortikoidnykh gormonov na pul i vnutrikletochnoe raspredelenie ubikhinona v tkaniakh krys