Serum insulin, insulin antibodies and insulin requirement in the first period of insulin treatment in non-insulin resistant diabetics.
Twelve insulin-sensitive diabetics were studied for 200 days after the initiation of mixed beef-pork NPH insulin. Normalization of the fasting blood glucose was not accompanied by any elevation in the pre-treatment fasting immunoreactive insulin level. Insulin antibodies appeared in 2 patients on the second week of insulin treatment, in 6 others within 87 days. In 4 patients no antibodies were found 200 days after the start of insulin. The appearance of antibodies was accompanied in two patients by a decrease in insulin requirement, in others there was no change. When antibodies were present, the total maximum insulin binding capacity was 4 to 12 U/l, but the total insulin constituted only 3 to 36% of the binding capacity. Insulin wastage caused by the destruction of the immune complexes was calculated to be 0.35 to 5.6 U/die only, and this explains the negligible effect of insulin antibodies on insulin requirement in non-resistant patients.
D000293:Adolescent; D000328:Adult; D000917:Antibody Formation; D000936:Antigen-Antibody Complex; D000941:Antigens; D001666:Binding Sites, Antibody; D001786:Blood Glucose / Q000032:analysis; D002648:Child; D003920:Diabetes Mellitus / Q000097:blood / Q000188:drug therapy / Q000276:immunology*; D006801:Humans; D007328:Insulin / Q000097:blood* / Q000627:therapeutic use; D007330:Insulin Antibodies / Q000302:isolation & purification*; D013997:Time Factors
D000936:Antigen-Antibody Complex; D000941:Antigens; D001786:Blood Glucose; D007328:Insulin; D007330:Insulin Antibodies