Methaqualone: tolerance and physical dependence in mice.
Tolerance and physical dependence was produced in C57Bl/6 male mice that had been exposed, for 36 days, to methaqualone in food pellets via an automated system. Tolerance was revealed in the reduction of sleep-times following intraperitoneal injection of methaqualone. Physical dependence was manifested as an alteration in neural sensitivity to flurothyl-induced convulsions.
D000818:Animals; D004361:Drug Tolerance; D005481:Flurothyl; D006801:Humans; D008297:Male; D008702:Methaqualone / Q000494:pharmacology*; D051379:Mice; D008810:Mice, Inbred C57BL; D009207:Myoclonus / Q000139:chemically induced; D011930:Reaction Time / Q000187:drug effects; D012640:Seizures / Q000139:chemically induced; D012890:Sleep / Q000187:drug effects; D013375:Substance Withdrawal Syndrome; D019966:Substance-Related Disorders
D008702:Methaqualone; D005481:Flurothyl