[Clinical study on rebleeding of cerebral anuerysms--with special references to the warning signs of rebleeding and antifibrinolytic treatment during waiting time for surgery (author's transl)].
The warning signs of rebleeding in the ruptured cerebral aneurysms, and the effect of antifibrinolytic treatment on the prevention of rebleeding from the ruptured aneurysms were studied and evaluated satistically by analysing the 62 single ruptured aneurysms. The incidennce of rebleeding during waiting time for surgery was higher in the following factors, i.e., the older patients, the Grade 2, the higher blood pressure, the larger aneurysms, the anterior-communicating aneurysms, the vasospasm. The critical time for rerupture was within three days after admission and within seven days after last bleeding. The anti-edema treatment and the sedation treatment have no effect upon the rebleeding. There was no difference in incidence of rebleeding among the sex and the frequency of bleeding before admission. The operative mortality of the reruptured patients during waiting time for surgery was very high. The antifibrinolytic treatment definitely lessened the incidence of rebleeding of the ruptured aneurysms during waiting time for surgery, and there were no noticeable complications following this treatment. This treatment is of value in the prevention of rebleeding from ruptured cerebral aneurysms during waiting time for surgery.
D000328:Adult; D000367:Age Factors; D000368:Aged; D001794:Blood Pressure; D005260:Female; D006801:Humans; D006993:Hypnotics and Sedatives / Q000627:therapeutic use; D002532:Intracranial Aneurysm / Q000188:drug therapy / Q000601:surgery; D002546:Ischemic Attack, Transient / Q000150:complications; D008297:Male; D008875:Middle Aged; D012008:Recurrence; D012422:Rupture, Spontaneous; D012737:Sex Factors; D013997:Time Factors; D014148:Tranexamic Acid / Q000627:therapeutic use
D006993:Hypnotics and Sedatives; D014148:Tranexamic Acid