title: Significance of serum lipoproteid-X (LP-X) determination for the diagnosis of cholestasis in chronic liver diseases.
abstract: Among 179 patients with various chronic diseases of the liver the authors found in 20 cases histological evidence of intrahepatic cholestasis and in all these cases lipoproteid X (LP-X) was present in the serum. In the group of 159 patients without evidence of cholestasis in microscopic examination of liver tissue LP-X was demonstrated only in two cases (1.3%). The results of investigations confirm the view that detection of LP-X in the serum is a specific and sensitive index of cholestasis and its value in the diagnosis of this condition is greater than that of determinations of alkaline phosphatase, gamma-glutamyl-transpeptidase, leucinamino-peptidase activity or cholesterol in the serum.
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D002779:Cholestasis / Q000097:blood / Q000175:diagnosis*; D002908:Chronic Disease; D004796:Clinical Enzyme Tests; D005260:Female; D006801:Humans; D008074:Lipoproteins / Q000097:blood*; D008107:Liver Diseases / Q000097:blood / Q000175:diagnosis*; D008297:Male; D008875:Middle Aged
chemical_list: D008074:Lipoproteins