[Radioprotective effect of pyrazolone derivatives].
The intraperitoneal injection of analgin (1000 mg/kg), antipurine (400 mg/kg), amidopyrine (100 mg/kg) 3 hours before the irradiation of mice in a dose of 800 R led to survival of 30 to 45% of the animals (against 12.5% in control) and to increase in the average duration of life of the animals that perished. 80-95% of mice survived the period of "intestinal deaths" (the 7th day after the irradiation) after combined prophylactic use of purasolone derivatives and cystamine before the irradiation of these animals in a dose of 1050 R. The radioprotective effect of pyrasolone derivatives given in therapeutic doses was less pronounced.
D000632:Aminopyrine / Q000627:therapeutic use*; D000818:Animals; D000983:Antipyrine / Q000627:therapeutic use*; D003538:Cystamine / Q000627:therapeutic use; D004177:Dipyrone / Q000627:therapeutic use; D004338:Drug Combinations; D005260:Female; D008297:Male; D051379:Mice; D010653:Phenylbutazone / Q000627:therapeutic use; D011833:Radiation Injuries, Experimental / Q000517:prevention & control*; D011837:Radiation-Protective Agents / Q000627:therapeutic use*
D004338:Drug Combinations; D011837:Radiation-Protective Agents; D000632:Aminopyrine; D004177:Dipyrone; D010653:Phenylbutazone; D003538:Cystamine; D000983:Antipyrine
Radiozashchitnyĭ éffekt nekotorykh proizvodnykh pirazolona