Ovarian dehydrogenase activities: suggested adrenal involvement in luteolysis.
Immature rat ovarian dehydrogenase activity was studied during corpus luteum regression following withdrawal of prior pregnant mare serum gonadotrophin. Glucose-6-phosphate dehydrogenase activity declined to nontreatment levels whereas 6-phosphogluconate, malate, and isocitrate dehydrogenase dehydrogenases exhibited a partial return to normal. Adrenalectomy prior to PMS withdrawal enhanced the decline in MAD while sharply elevating G6PD and 20alpha-hydroxysteroid dehydrogenase. Corticosterone and progesterone prevented the G6PD changes induced by adrenalectomy and moderated the rise in 20alpha-OHSD. Adrenalectomy appears to enhance the process of luteolysis.
D000315:Adrenalectomy; D000429:Alcohol Oxidoreductases / Q000378:metabolism*; D000818:Animals; D003345:Corticosterone / Q000494:pharmacology; D005260:Female; D005954:Glucosephosphate Dehydrogenase / Q000378:metabolism; D006064:Gonadotropins, Equine / Q000494:pharmacology; D006913:Hydroxysteroid Dehydrogenases / Q000378:metabolism; D007521:Isocitrate Dehydrogenase / Q000378:metabolism; D003341:Luteolysis / Q000187:drug effects; D008291:Malate Dehydrogenase / Q000378:metabolism; D010053:Ovary / Q000201:enzymology*; D010734:Phosphogluconate Dehydrogenase / Q000378:metabolism; D011374:Progesterone / Q000494:pharmacology; D051381:Rats
D006064:Gonadotropins, Equine; D011374:Progesterone; D000429:Alcohol Oxidoreductases; D006913:Hydroxysteroid Dehydrogenases; D008291:Malate Dehydrogenase; D007521:Isocitrate Dehydrogenase; D010734:Phosphogluconate Dehydrogenase; D005954:Glucosephosphate Dehydrogenase; D003345:Corticosterone