Side chain oxidation of ifosfamide in man.
Ifosfamide as well as its stable alkylating metabolites namely carboxy-Ifosfamide and two dechloroethylated compounds were determined in the urine of a patient with progredient lung carcinoma who had been treated with 6 g of the drug. Quantitative measurements were carried out using a colorimetric procedure which consists of TL-spectrophotometric determinations on sheets which had previously been sprayed with 4-pyridinaldehyde-2-benzothiazolylhydrazone. In the case investigated the Ifosfamide was found to have been converted largely into two dechloroethylated compounds (48%) and only a small portion of carboxy-Ifosfamide (2.2%).
D000478:Alkylation; D003124:Colorimetry / Q000379:methods; D003520:Cyclophosphamide / Q000031:analogs & derivatives* / Q000378:metabolism; D006801:Humans; D007069:Ifosfamide / Q000378:metabolism* / Q000652:urine; D010084:Oxidation-Reduction; D013053:Spectrophotometry
D003520:Cyclophosphamide; D007069:Ifosfamide