Nicotinic acid reduction of plasma volume loss after thermal trauma.
Intravenous administration of nicotinic acid to the anesthetized dog prior to thermal trauma reduced plasma loss at 10 minutes after burn from 7 milliliters per kilogram to less than 2 millimeters per kilogram. During the next 50 minutes plasma loss was the same in treated and untreated animals. An additional dose of nicotinic acid 30 minutes after burn prevented this further loss.
D000818:Animals; D002056:Burns / Q000188:drug therapy* / Q000503:physiopathology; D002199:Capillary Permeability / Q000187:drug effects; D004285:Dogs; D005230:Fatty Acids, Nonesterified / Q000097:blood; D005260:Female; D008297:Male; D009539:Nicotinic Acids / Q000494:pharmacology / Q000627:therapeutic use*; D010953:Plasma Volume / Q000187:drug effects; D011453:Prostaglandins / Q000096:biosynthesis
D005230:Fatty Acids, Nonesterified; D009539:Nicotinic Acids; D011453:Prostaglandins