Decreased citrate synthesis: possible indication of early degenerative changes in testes of vitamin E-deficient rats.
We have shown that intravenously administered glucose disappears from the blood of E-deficient rats at different rates compared to that of the control rats and that this difference could possibly be explained by membrane permeability changes in E-deficiency. We have also shown that the ability of E-deficient rat testis tissue to synthesize citrate is decreased, and that this decrease is probably an early manifestation of testicular degeneration.
D000085:Acetates / Q000378:metabolism; D000818:Animals; D001835:Body Weight / Q000187:drug effects; D002250:Carbon Radioisotopes; D002951:Citrates / Q000096:biosynthesis*; D004032:Diet; D005947:Glucose / Q000008:administration & dosage / Q000378:metabolism; D007263:Infusions, Parenteral; D008297:Male; D051381:Rats; D013737:Testis / Q000378:metabolism* / Q000473:pathology; D014810:Vitamin E / Q000008:administration & dosage / Q000097:blood; D014811:Vitamin E Deficiency / Q000378:metabolism*
D000085:Acetates; D002250:Carbon Radioisotopes; D002951:Citrates; D014810:Vitamin E; D005947:Glucose