Pharmacokinetics of a single dose of phenytoin in man measured by radioimmunoassay.
1. Serum concentrations of phenytoin were studied by radioimmunoassay in five normal volunteers following a single oral dose of phenytoin sodium (100 mg). 2. Two distinct peaks were found at 2.5-3.5 and 10-12 h after ingestion. Maximum serum concentrations ranged from 1.56 mug/ml. The mean plasma half-life of the drug under these conditions was 9.81 +/- 0.66 (s.e. mean) hours.
D000284:Administration, Oral; D000328:Adult; D006207:Half-Life; D006801:Humans; D007700:Kinetics; D010672:Phenytoin / Q000008:administration & dosage / Q000097:blood*; D011863:Radioimmunoassay / Q000379:methods
D010672:Phenytoin