[Change in the alkaline phosphatase activity and glycogen content in the leukocytes of white rat blood under the influence of penicillin preparations].
The contents of alkaline phosphatase and glycogen in the neutrophils of the peripheral blood of unbred albino rats weighing 170-200 gm were determined. Benzylpenicillin and oxacillin in doses of 50000 and 20000 Units/kg respectively were administered intramuscularly once a day over a long period of time. Two-phase changes in the contents of alkaline phosphatase and glycogen under the effect of penicillin were found. An increase in their contents was observed on the 5-10th days then it was followed by a decrease. Increase in the contents of the metabolites proceeded simultaneously with enhancing of the digestive capacity of the leucocytes and activity of lysozyme in them.
D000469:Alkaline Phosphatase / Q000097:blood*; D000818:Animals; D006003:Glycogen / Q000378:metabolism*; D007962:Leukocytes / Q000187:drug effects* / Q000378:metabolism; D010068:Oxacillin / Q000494:pharmacology; D010400:Penicillin G / Q000494:pharmacology; D010406:Penicillins / Q000494:pharmacology*; D051381:Rats; D013997:Time Factors
D010406:Penicillins; D006003:Glycogen; D000469:Alkaline Phosphatase; D010400:Penicillin G; D010068:Oxacillin
Izmenenie aktivnosti shchelochnoĭ f osfatazy i soderzhanaiia glikogena v leĭkotsitakh krovi belykh krys pod vliianiem preparatov penitsillina