[In vivo action of valinomycin on Ehrlich ascites tumor cells. Inhibition of the proliferative activity of the tumor cells under the action of valinomycin].
It was shown that repeated administrations of valinomycin in doses of 1.0 and 0.01 gamma/gm to mice with Ehrlich ascitic tumors inhibited the ascite development. The radioautographic study using 3H-thimidine showed that 24 hours after the administration of valinomycin in doses of 0.1 and 0.01 gamma/gm transference of the cells into the phase of DNA synthesis was inhibited--inhibition of the tumor cell mitotic activity took place.
D000818:Animals; D001835:Body Weight / Q000187:drug effects; D002286:Carcinoma, Ehrlich Tumor / Q000188:drug therapy* / Q000378:metabolism; D002471:Cell Transformation, Neoplastic / Q000187:drug effects*; D004273:DNA, Neoplasm / Q000096:biosynthesis; D003864:Depression, Chemical; D051379:Mice; D008938:Mitosis / Q000187:drug effects; D009368:Neoplasm Transplantation; D013936:Thymidine / Q000378:metabolism; D013997:Time Factors; D014316:Tritium; D014634:Valinomycin / Q000494:pharmacology*
D004273:DNA, Neoplasm; D014316:Tritium; D014634:Valinomycin; D013936:Thymidine
Deĭstvie valinomitsina in vivo na kletki astsitnoĭ opukholi Erlikha. Tormozhenie proliferativnoĭ aktivnosti opukholevykh kletok pod vliianiem valinomitsina