A sensitive GLC method for the determination of imipramine and desmethylimipramine using a nitrogen detector.
A sensitive method for determination of imipramine and desmethylimipramine using a GLC system fitted with a new nitrogen detector is described. The lower limit of sensitivity is less than 1 ng/ml with a lower limit enabling quantitation with acceptable precision of 3-5 ng/ml. Data from 20 control subjects given a single oral dose of imipramine are shown.
D002849:Chromatography, Gas / Q000295:instrumentation; D003891:Desipramine / Q000032:analysis* / Q000097:blood; D006801:Humans; D006900:Hydroxylation; D007099:Imipramine / Q000032:analysis* / Q000097:blood; D008722:Methods; D009584:Nitrogen; D013997:Time Factors
D009584:Nitrogen; D007099:Imipramine; D003891:Desipramine