Unusual cardiac reaction to chemotherapy following mediastinal irradiation in a patient with Hodgkin's disease.
A 27 year old man with Hodgkin's disease experienced three separate episodes of chest pain, each occurring on the sixth day of a cycle of mustargen, oncovin, procarbazine, prednisone (MOPP) combination chermotherapy. The first episode appeared to represent a myocardial infarction, whereas the next two were less serious. Numerous studies were performed including coronary angiography, cardiac catheterization and open pericardial biopsy. It is suggested that the patient represents an example of a previously undescribed syndrome due to chemotherapy administered after cardiac irradiation.
D000328:Adult; D004359:Drug Therapy, Combination / Q000009:adverse effects*; D006321:Heart / Q000187:drug effects / Q000528:radiation effects; D006689:Hodgkin Disease / Q000188:drug therapy / Q000532:radiotherapy*; D006801:Humans; D008297:Male; D008466:Mechlorethamine / Q000009:adverse effects; D008479:Mediastinal Neoplasms / Q000188:drug therapy / Q000532:radiotherapy*; D009203:Myocardial Infarction / Q000139:chemically induced*; D010493:Pericarditis / Q000139:chemically induced; D011241:Prednisone / Q000009:adverse effects; D011344:Procarbazine / Q000009:adverse effects; D011832:Radiation Injuries / Q000209:etiology*; D011867:Radioisotope Teletherapy / Q000009:adverse effects*; D014750:Vincristine / Q000009:adverse effects
D011344:Procarbazine; D008466:Mechlorethamine; D014750:Vincristine; D011241:Prednisone