title: [Dependence on age of the effects of catecholamines in man I. Effect of noradrenaline, adrenaline and isoprenaline on blood pressure and heart rate].
abstract: In 2- to 3-year-old, 18- to 34-year-old as well as 57- to 75-year-old persons the effect of a one hour's permanent infusion of noradrenalin (0.0625 mug/min kg), adrenalin (0.025 mug/min kg) and isoprenalin (0.0142 mug/min kg) on blood pressure and hear rate is investigated. In a concerning age uniform dosage/body weight isoprenalin and adrenalin increase the heart rate of the older organism on a larger scale than in the younger. The increased sensitiveness of the heart of old persons to beta-adrenergics is to be taken in consideration in therapeutic use with regard to cardiac side effects. In juvenile adults the systolic blood pressure is more increased by isoprenalin as well as the diastolic blood pressure by noradrenalin than in older persons. The concerning age different cardiovascular effects of the investigated adrenergics in man are discussed in connection with findings of animal experiments with regard to aging in the sensitiveness of adrenergic receptors.
mesh_terms: D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000368:Aged; D000375:Aging; D001794:Blood Pressure / Q000187:drug effects*; D002675:Child, Preschool; D004837:Epinephrine / Q000494:pharmacology*; D005260:Female; D006339:Heart Rate / Q000187:drug effects*; D006801:Humans; D007545:Isoproterenol / Q000494:pharmacology*; D008297:Male; D008875:Middle Aged; D009638:Norepinephrine / Q000494:pharmacology*; D013997:Time Factors
chemical_list: D007545:Isoproterenol; D009638:Norepinephrine; D004837:Epinephrine
vernacular_title: Zur Altersabhängigkeit von Katecholaminwirkungen beim Menschen I. Einfluss von Noradrenalin, Adrenalin und Isoprenalin auf den Blutdruck und die Herzfrequenz