Immunoglobulins in persons with long-term exposure to halothane.
In 18 persons (anaesthetists and anaesthetic nurses) with a history of long-term exposure to low concentrations of halothane the activity of aminotransferases, GGTP, and alkaline phosphatase, the bilirubin level and thymol turbidity test were determined and no significant abnormalities were found. On the other hand, determinations of immunoglobulons showed changes in the raised IgM level in 15 out of 18 persons, the difference between the normal level and that found in the present studies being statistically significant. The levels of IgA and IgG were within the normal range. Raised IgM level may be due to stimulation of the immune system by halothane.
D000328:Adult; D000368:Aged; D000469:Alkaline Phosphatase / Q000097:blood; D000776:Anesthesiology; D001663:Bilirubin / Q000097:blood; D004781:Environmental Exposure; D005260:Female; D006221:Halothane / Q000506:poisoning*; D006801:Humans; D007109:Immunity / Q000187:drug effects; D007070:Immunoglobulin A / Q000032:analysis; D007074:Immunoglobulin G / Q000032:analysis; D007075:Immunoglobulin M / Q000032:analysis; D007136:Immunoglobulins / Q000032:analysis*; D008099:Liver / Q000187:drug effects*; D008297:Male; D008875:Middle Aged; D009719:Nurse Anesthetists; D009784:Occupational Diseases / Q000139:chemically induced*; D010458:Peptidyl Transferases / Q000097:blood; D013943:Thymol; D013997:Time Factors; D000637:Transaminases / Q000097:blood
D007070:Immunoglobulin A; D007074:Immunoglobulin G; D007075:Immunoglobulin M; D007136:Immunoglobulins; D013943:Thymol; D010458:Peptidyl Transferases; D000637:Transaminases; D000469:Alkaline Phosphatase; D001663:Bilirubin; D006221:Halothane