title: Bis-(p-hydroxyphenyl)-pyridyl-2-methane: The common laxative principle of Bisacodyl and sodium picosulfate.
abstract: After both oral and rectal administration in humans (4,4'-diacetoxy-diphenyl)-(pyridyl-2)-methane (bisacodyl, Dulcolax) and 4,4'-(2-pyridyl-methylene)-diphenol-disulfuric acid semiester disodium (sodium picosulfate, Laxoberal) are hydrolyzed to bis-(p-hydroxyphenyl)-pyridyl-2-methane (BHPM). In both cases BHPM is responsible for the laxative action. Experiments in rats and guinea pigs have shown that the hydrolysis of picosulfate, in contrast to that of bisacodyl, is attributable to the microorganisms of the intestinal flora.
mesh_terms: D000284:Administration, Oral; D000328:Adult; D000818:Animals; D001726:Bisacodyl / Q000008:administration & dosage / Q000032:analysis / Q000378:metabolism*; D002400:Cathartics / Q000008:administration & dosage / Q000378:metabolism*; D003248:Constipation / Q000188:drug therapy; D003408:Cresols / Q000378:metabolism*; D005243:Feces / Q000032:analysis; D005260:Female; D005856:Germ-Free Life; D006168:Guinea Pigs; D006801:Humans; D006868:Hydrolysis; D007422:Intestines / Q000382:microbiology; D008297:Male; D008875:Middle Aged; D009355:Neomycin / Q000494:pharmacology; D010847:Picolines / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000032:analysis / Q000378:metabolism; D051381:Rats; D013488:Suppositories; D013997:Time Factors
chemical_list: D002400:Cathartics; D003408:Cresols; D010847:Picolines; D013488:Suppositories; D001726:Bisacodyl; D009355:Neomycin