title: Amniotic fluid osmolality in pregnancies complicated by diabetes.
abstract: Amniotic fluid osmolality (AF Osm) was studied in 247 patients whose pregnancies were complicated by maternal diabetes. Significant increases in mean AF Osm accompanied pre-existing fetal as well as subsequent perinatal death. Abnormal increases in AF Osm were associated with a significant increase in risk of perinatal compromise with cumulative morbidity and mortality rates of 54 per cent. These data suggest that serial evaluation of AF Osm enables detection of a "higher risk" group of diabetic pregnancies in which perinatal death is more than doubled.
mesh_terms: D000293:Adolescent; D000328:Adult; D000653:Amniotic Fluid / Q000032:analysis*; D001724:Birth Weight; D005260:Female; D005313:Fetal Death; D005316:Fetal Distress / Q000209:etiology; D005311:Fetal Hypoxia / Q000209:etiology; D005865:Gestational Age; D006801:Humans; D007003:Hypoglycemia / Q000209:etiology; D007231:Infant, Newborn; D007232:Infant, Newborn, Diseases / Q000209:etiology / Q000401:mortality; D009994:Osmolar Concentration; D011247:Pregnancy; D011249:Pregnancy Complications, Cardiovascular; D011254:Pregnancy in Diabetics / Q000150:complications*; D014883:Water-Electrolyte Imbalance / Q000150:complications