[Glycemia and the levels of free fatty acids in small-for-date born infants after monosaccharide load. Communication I (author's transl)].
In order to evaluate some aspects of carbohydrate metabolism in small-for-date born infants the authors have performed in them the glucose tolerance test. The glycemic reflex was estimated in relation to the free fatty acids level (FFA). This was done twice a year in the first half year of life and in the second one. We compared the results with data obtained form full-size born infants tested in the same of time. The group of small-for-date born (SRDB) infants included 23 infants in the first half year and 12 in the second one. The SFDB infants were loaded with glucose and galactose given to them in a dosis of 1 g of each sugar in a 15% solution. The following micromethods were applied: Hyvarinen and Nikkila for glucose, and Dole and Meinertz in Novak's modification for FFA. The level of glucose and FFA were estimated at fasting and after loading at 20, 40, 90, 120 and 180 minutes. In order to be able to evaluate the results, the authors performed the variance analysis. On the basis a significantly higher variability of FFA levels was found in comparison with glucose levels as well as a variability of the two parameters significantly higher in small-for-date born infants than in full-size born infants. In spite of that in standarized mean values a relationship between glucose and FFA levels was found in small-for-date born infants opposite to that in full-size born infants. In the former the glucose levels and free fatty acids were higher then in the latter. This phenomenon disappeared in the second half-year of life. The disappearance rate (as measured by coefficient K) was slightly higher than in the second half year. In the second half year this difference was not noted between the observed parameters in two groups of infants. If it may be concluded on the basis of the authors' observations, the higher levels of glucose in small-for-date born infants in their first half year of life could indicate some disturbance in glucose utilization and the higher level of FFA then usually found in fullsize born infants during the oral glucose tolerance test might be an additional proof for the above.
D000367:Age Factors; D001724:Birth Weight; D001786:Blood Glucose / Q000032:analysis*; D005230:Fatty Acids, Nonesterified / Q000097:blood*; D005260:Female; D005951:Glucose Tolerance Test; D006801:Humans; D007223:Infant; D009005:Monosaccharides; D011247:Pregnancy
D001786:Blood Glucose; D005230:Fatty Acids, Nonesterified; D009005:Monosaccharides
Glikemia i poziomy wolnych kwasów tłuszczowych po obciazeniu cukrami prostymi u niemowlat urodzonych z dystrofia wewnatrzłonowa doniesienie I