title: The effect of codeine phosphate on the absorption of ethyl alcohol.
abstract: The effect of syrup, B.P. and codeine phosphate syrup, B.P.C. on blood alcohol levels was determined in six normal subjects. 2 Treatment with syrup alone had little or no influence on the concentration of ethanol in blood. 3 In contrast, pretreatment with codeine phosphate syrup significantly reduced alcohol absorption, as assessed by the maximum blood levels achieved or the area subtended by the blood concentration-time curve. It is suggested that the diminished absorption of ethanol is related to the pharmacological action of codeine on the stomach. 4 It was considered that the concentration of ethanol in linctuses or syrups containing codeine was unlikely to have any significant effect on the central nervous system.
mesh_terms: D003061:Codeine / Q000031:analogs & derivatives* / Q000494:pharmacology*; D004338:Drug Combinations; D000431:Ethanol / Q000008:administration & dosage / Q000378:metabolism*; D006801:Humans; D007408:Intestinal Absorption / Q000187:drug effects*
chemical_list: D004338:Drug Combinations; D000431:Ethanol; D003061:Codeine