Experimental drug intoxication: treatment with charcoal haemoperfusion.
Dogs were given large doses of barbiturates, glutethimide, ethanol, methaqualone, ethchlorvynol, meprobamate, chloral hydrate, paracetamol and aspirin. These were treated by haemoperfusion using a column packed with charcoal coated with an acrylic hydrogel. Clearances for most drugs were significantly higher than those reported for haemodialysis. Minimal clearances of common biochemical entities were observed and although leucocyte and platelet counts were diminished, no deleterious effects attributable to this were encountered. Careful histological examination of tissues derived from perfused dogs revealed no evidence of charcoal emboli.
D000082:Acetaminophen / Q000506:poisoning; D000435:Alcoholic Intoxication / Q000188:drug therapy; D000818:Animals; D001241:Aspirin / Q000506:poisoning; D001463:Barbiturates / Q000506:poisoning; D001672:Biocompatible Materials; D002606:Charcoal / Q000627:therapeutic use*; D002697:Chloral Hydrate / Q000506:poisoning; D004285:Dogs; D004353:Drug Evaluation, Preclinical; D004984:Ethchlorvynol / Q000506:poisoning; D005984:Glutethimide / Q000506:poisoning; D006801:Humans; D008620:Meprobamate / Q000506:poisoning; D008657:Metabolic Clearance Rate; D008702:Methaqualone / Q000506:poisoning; D010477:Perfusion / Q000379:methods*; D011041:Poisoning / Q000097:blood / Q000188:drug therapy*; D006435:Renal Dialysis; D013499:Surface Properties
D001463:Barbiturates; D001672:Biocompatible Materials; D002606:Charcoal; D000082:Acetaminophen; D002697:Chloral Hydrate; D004984:Ethchlorvynol; D008702:Methaqualone; D008620:Meprobamate; D005984:Glutethimide; D001241:Aspirin