[Effect of audiogenic convulsions on the activity of n- and m-forms of lactate dehydrogenase in the neurons and neuroglia of different sections of central nervous system].
It was shown spectrophotometrically that in Krushinsky-Molodkina and Wistar rats the ratio of the activity of the aerobic H-forms of lactic dehydrogenase (LDH) to the activity of the anaerobic M-forms was higher in the neurons of the cerebral cortex and the Purkinje's cells of the cerebellum and in their glial cells-satellites than in the motor neurons of the anterior horns of the spinal cord and their perineuronal glia. In Krushinsky-Molodkina rats (with genetically-determined high sensitivity to audiogenic convulsions) epileptiform attacks under the effect of sound were accompanied by a marked activation of both the H- and the M-forms of LDH in the cortical neurons in the absence of any shifts in the perineuronal glia. On the contrary, the activity of all the forms of LDH was unchanged in the spinal motor neurons, whereas in the neuroglia cells surrounding these neurons there was a distinct increase in the activity of the H-forms of LDH. In the Purkinje's cells of the cerebellum an increase and in the glial cells- satellites -- a reduction of the activity of the M-forms of LDH in case of convulsions was seen.
D000161:Acoustic Stimulation; D000332:Aerobiosis; D000693:Anaerobiosis; D000818:Animals; D002490:Central Nervous System / Q000201:enzymology*; D002540:Cerebral Cortex / Q000201:enzymology; D006651:Histocytochemistry; D007527:Isoenzymes; D007770:L-Lactate Dehydrogenase / Q000378:metabolism*; D008297:Male; D009046:Motor Neurons / Q000201:enzymology; D009457:Neuroglia / Q000201:enzymology*; D009474:Neurons / Q000201:enzymology*; D011689:Purkinje Cells / Q000201:enzymology; D051381:Rats; D011919:Rats, Inbred Strains; D012640:Seizures / Q000201:enzymology*; D013127:Spinal Nerves / Q000201:enzymology
D007527:Isoenzymes; D007770:L-Lactate Dehydrogenase
Vliianie audiogennykh sudorog na aktivnost' n- i m-form laktatdegidrogenazy v neĭronakh i neĭroglii razlichnykh otdelov tsentral' nervnoi noĭ sistemy