Uric acid degradation by Bacillus fastidiosus strains.
Seven Bacillus strains including one of the original Bacillus fastidiosus strains of Den Dooren de Jong could grow on urate, allantoin, and, except one, on allantoate. No growth could be detected on adenine, guanine, hypoxanthine, xanthine, and on degradation products of allantoate. Some strains grew very slowly in complex media. The metabolic pathway from urate to glyoxylate involved uricase, S(+)-allantoinase, allantoate amidohydrolase, S(-)-ureidoglycolase, and, in some strains, urease.
D000481:Allantoin / Q000378:metabolism; D000581:Amidohydrolases / Q000378:metabolism; D001407:Bacillus / Q000201:enzymology / Q000254:growth & development / Q000378:metabolism*; D002474:Cell-Free System; D004790:Enzyme Induction; D008190:Lyases / Q000378:metabolism; D013045:Species Specificity; D013171:Spores, Bacterial / Q000254:growth & development; D014503:Urate Oxidase / Q000378:metabolism; D014508:Urea / Q000378:metabolism; D014510:Urease / Q000378:metabolism; D014512:Ureohydrolases / Q000378:metabolism; D014527:Uric Acid / Q000378:metabolism*
D014527:Uric Acid; D000481:Allantoin; D014508:Urea; D014503:Urate Oxidase; D000581:Amidohydrolases; D014510:Urease; D014512:Ureohydrolases; D008190:Lyases