title: Accumulation of 42K and 86Rb in the organs of the rat.
abstract: 42K and 86Rb were administered in combination to anaesthetized rats by the intravenous route, and accumulation of the isotopes in the organs during a few cirulatory cycles (90 sec) and after 24 hours has been studied in the rat. a) Accumulation of the two elements was identical in skeletal and heart muscle at both points of time. b) Acute (90 sec) accumulation of 86Rb slightly exceeded that of 42K in the skin, liver, brain, external and internal medulla of the kidney. Therefore, the cardiac output fractions obtained with 42K and 86Rb according to Sapirstein's method must be compared with certain corrections, and they cannot be evaluated in a combined form. c) Considerable differences were found in the accumulation of the two elements after 24 hours. The differences were ascribed to the different intra- and extracellular concentrations of the natural isotopes of the two elements and, to a lesser extent to their presumbly different "lag phenomenon".
mesh_terms: D000818:Animals; D001842:Bone and Bones / Q000378:metabolism; D001921:Brain / Q000378:metabolism; D005260:Female; D007668:Kidney / Q000378:metabolism; D008099:Liver / Q000378:metabolism; D008168:Lung / Q000378:metabolism; D008297:Male; D009132:Muscles / Q000378:metabolism; D009928:Organ Specificity; D011188:Potassium / Q000097:blood / Q000378:metabolism*; D011197:Potassium Radioisotopes / Q000378:metabolism; D011849:Radioactive Tracers; D051381:Rats; D012413:Rubidium / Q000097:blood / Q000378:metabolism*; D012867:Skin / Q000378:metabolism; D013997:Time Factors
chemical_list: D011197:Potassium Radioisotopes; D011849:Radioactive Tracers; D012413:Rubidium; D011188:Potassium