[Physical factors in animal experiments for testing antimasspsychotic drugs].
Lemmingson et al. have observed that the movement of masspsychotic lemmings (Lemmus lemmus) shows a distinct preference for the left direction. They suggested that this is due to the influence of the Coriolis force. According to this proposition the influence of the Coriolis force on a group of masspsychotic animals has been investigated quantitatively. The results suggest the following model: Normally the influence of the Coriolos force, which on the northern hemisphere acts to the right, is compensated by a neuromuscular feedback mechanism. The tendency towards the left under masspsychotic conditions corresponds to overcompensation. The tendency to the left should also be observed on the southern hemisphere, if the direction of this compensation is determined genetically. Therefore, the test proposed by Lemmingson et al. is not suited to distinguish between the influence of the Coriolis force and the influence of biologically active left-isomer molecules.
D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects*; D003312:Coriolis Force; D004292:Dominance, Cerebral; D004353:Drug Evaluation, Preclinical; D007839:Functional Laterality; D006801:Humans; D008399:Mass Behavior / Q000187:drug effects*; D008968:Molecular Conformation; D011618:Psychotic Disorders; D011619:Psychotropic Drugs / Q000494:pharmacology*; D012377:Rodentia / Q000502:physiology*; D013239:Stereotyped Behavior / Q000187:drug effects
D011619:Psychotropic Drugs
Physikalische Faktoren bei Tierversuchen zur Testung anti-massenpsychotisch wirkender Pharmaka