Insulin response to intravenous glucagon in children with familial constitutional short stature.
An intravenous glucagon test was performed in 8 children with familial constitutional short stature who were also lean. These children were randomly selected from a larger group of children with the same clinical manifestation and who had been shown to have a low insulin response to an oral glucose tolerance test and to an intravenous arginine test, without glucose intolerance. 7 out of 8 children showed a normal insulin response to intravenous glucagon, with a peak level of 53--180 millimicron/ml 2 minutes after the injection. It is assumed that these insulin responses represent an intact 'rapid' pool of insulin within the beta-cell, and can explain the absence of glucose intolerance in all the children so far studied.
D001786:Blood Glucose / Q000032:analysis; D001827:Body Height; D002648:Child; D005260:Female; D005934:Glucagon; D006801:Humans; D007275:Injections, Intravenous; D007328:Insulin / Q000097:blood*; D008297:Male
D001786:Blood Glucose; D007328:Insulin; D005934:Glucagon