Synthesis of N-hydroxythiourea.
The synthesis of the title compound (1) was accomplished by the conversion of 2,4-dimethoxybenzylamine (2) into an isothiocyanate (3) using thiocarbonyl diimidazole. Treatment of 3 with hydroxylamine and removal of the DMB group with trifluoroacetic acid gave 1. N-Hydroxythiourea (1) showed no activity in the L1210 mouse tumor.
D000818:Animals; D007939:Leukemia L1210 / Q000188:drug therapy; D051379:Mice; D013890:Thiourea / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000627:therapeutic use
C011871:N-hydroxythiourea; D013890:Thiourea