[Comparison of the anti-arrhythmia and local anesthetizing actions of some substances].
A comparison of antiarrhythmic activity of substances (stimulation of the heart with electric current and measuring the duration of the refractory peroid) as against their local anesthetic properties (the eye cornea of the rabbit and the ischiatic nerve of the frog) proved the existence of a close correlation between the ability of substances to abolish arrhythmia, caused by an electric stimulation of the heart, and their capacity to produce a conduction anesthesia in the ischiatic nerve of a decapitated frog.
D000765:Anesthesia, Conduction; D000779:Anesthetics, Local / Q000494:pharmacology*; D000818:Animals; D000889:Anti-Arrhythmia Agents / Q000494:pharmacology*; D001145:Arrhythmias, Cardiac / Q000188:drug therapy; D003315:Cornea / Q000187:drug effects; D004558:Electric Stimulation; D004983:Ethanolamines / Q000494:pharmacology; D006321:Heart / Q000187:drug effects / Q000502:physiology; D008779:Methylthiouracil / Q000494:pharmacology; D011343:Procaine / Q000494:pharmacology; D011433:Propranolol / Q000494:pharmacology; D011802:Quinidine / Q000494:pharmacology; D011817:Rabbits; D012584:Sciatic Nerve / Q000187:drug effects; D013997:Time Factors
D000779:Anesthetics, Local; D000889:Anti-Arrhythmia Agents; D004983:Ethanolamines; D011343:Procaine; D011433:Propranolol; D011802:Quinidine; D008779:Methylthiouracil
Sopostavlenie protivoaritmicheskoĭ i mestoanesteziruiushcheĭ aktivnosti nekotorykh veshchestv