title: H3-phenylalanine incorporation into protein in the pituitary, hypothalamus and cerebral cortex of male rats during postnatal development.
abstract: Incorporation of H3-phenylalanine and concentration of protein in the anterior pituitary gland (APG), hypothalamus and cerebral cortex of male rats have been studied during postnatal development from day 21 to 120. APG and hypothalamus showed significantly higher rate of amino acid uptake and protein synthesis during the prepubertal phase, decrease at puberty and an age dependent variation thereafter. Protein concentrations and amino acid incorporation in the APG and hypothalamus are possibly influenced by the higher circulating levels of androgens during sexual maturation in marked contrast to their lack of effect on the cerebral cortex.
mesh_terms: D000367:Age Factors; D000728:Androgens / Q000378:metabolism; D000818:Animals; D002540:Cerebral Cortex / Q000378:metabolism*; D006128:Growth; D007031:Hypothalamus / Q000378:metabolism*; D009419:Nerve Tissue Proteins / Q000096:biosynthesis / Q000378:metabolism; D010649:Phenylalanine / Q000378:metabolism*; D010902:Pituitary Gland / Q000378:metabolism*; D010903:Pituitary Gland, Anterior / Q000378:metabolism*; D051381:Rats
chemical_list: D000728:Androgens; D009419:Nerve Tissue Proteins; D010649:Phenylalanine