Salicylate removal by charcoal haemoperfusion in experimental intoxication in dogs:an assessment of efficacy and safety.
The removal of salicylate by extracorporeal circulation of blood through a column of encapsulated activated charcoal (haemoperfusion) has been studied experimentally in intoxicated dogs (greyhounds). The average time taken to reduce the whole blood salicylate level to one-half of the initial equilibrium level in 30 kg dogs was 2 hrs. A half-life of 3 hrs is predicted for salicylate removal by haemoperfusion in a 70 kg man and this rate of removal is shown to be comparable to that reported for haemodialysis. No unacceptable adverse physiological, biochemical, or haematological effects were found to result from haemoperfusion. The possible use of this technique in the management of severe salicylate poisoning in man is discussed. Haemoperfusion is foreseen as providing a method of rapid removal of salicylate in circumstances where forced diuresis is contra-indicated or inadequate and haemodialysis is not readily available.
D000818:Animals; D001769:Blood; D001792:Blood Platelets; D002606:Charcoal / Q000627:therapeutic use*; D004285:Dogs; D006207:Half-Life; D006801:Humans; D007700:Kinetics; D008297:Male; D010477:Perfusion / Q000295:instrumentation / Q000379:methods*; D011041:Poisoning / Q000628:therapy; D006435:Renal Dialysis; D012459:Salicylates / Q000097:blood / Q000506:poisoning*
D012459:Salicylates; D002606:Charcoal