Influence of the hypophysis on mitochondrial protein synthesis.
Hypophysectomy significantly decreased the capacity to synthesize protein by isolated liver and skeletal muscle mitochondria. Total hypophyseal extract, growth hormone or thyroxine administered to the whole animal in adequate doses prior to sacrifice enhanced protein synthesis to values similar or higher to those of the control, especially in the case of thyroxine.
D000818:Animals; D013006:Growth Hormone / Q000378:metabolism*; D007016:Hypophysectomy; D008297:Male; D008930:Mitochondria, Liver / Q000378:metabolism*; D008931:Mitochondria, Muscle / Q000378:metabolism*; D014176:Protein Biosynthesis; D051381:Rats; D013974:Thyroxine / Q000378:metabolism
D013006:Growth Hormone; D013974:Thyroxine