title: The effect of intramuscular salbutamol in asthmatics.
abstract: 1 In a double-blind placebo controlled dose-response experiment in six asthmatic patients with reversible airways obstruction the effect of i.m. salbutamol (4 mug/kg, 8 mug/kg or 12 mug/kg) was assessed by improvement in spirometry and change in pulse rate. 2 Salbutamol (8 mug/kg) resulted in a mean increase in FEV1 of 1 litre and a mean increase in pulse rate of 7 beats/minute. 3 It was concluded that salbutamol (8 mug/kg) was the optimal dose.
mesh_terms: D000328:Adult; D000420:Albuterol / Q000008:administration & dosage* / Q000009:adverse effects / Q000627:therapeutic use; D001249:Asthma / Q000188:drug therapy*; D004305:Dose-Response Relationship, Drug; D004341:Drug Evaluation; D006801:Humans; D007273:Injections, Intramuscular; D008297:Male; D010919:Placebos
chemical_list: D010919:Placebos; D000420:Albuterol