[Metabolism of Co58 labelled vitamin B12 in white rats under normal conditions and in starvation].
The effect of complete facting on the distribution of vitamin B12-Co58 in the organs of albino rats and excretion of the label from their organism were studied. Complete fasting did not alter the order in which the summary amount of the labelled compound accumulated in different organs. After 2 days of complete fasting in animals sacrificed 3 and 24 hours following introduction of the tagged vitamin the incorporation of the atter in the organs drastically decreased by comparison with controls. In the group of animals sacrificed 3 hours after introduction of the tagged vitamin two peaks of mounting relative specific radioactivity (RSR) of the organs were detected, viz. on the 4th and 11th day. In the group of animals sacrificed 24 hours after introduction of the vitamin B12-CO58 the RSR of the organs began to rise starting from the 4th day and continued up to and including the 11th day of complete fasting. On introduction of B12-Co58 to the animals complete fasting doubled the rate of the radioactivity passage with urine and feces.
D000818:Animals; D003037:Cobalt Radioisotopes; D005243:Feces / Q000032:analysis; D007408:Intestinal Absorption; D008297:Male; D051381:Rats; D013217:Starvation / Q000378:metabolism*; D013997:Time Factors; D014805:Vitamin B 12 / Q000378:metabolism* / Q000652:urine
D003037:Cobalt Radioisotopes; D014805:Vitamin B 12
Obmen mechennogo Co58 vitamina B12 u belykh krys v norme i pri golodanii