The anti=inflammatory properties of isoxicam (4-hydroxy-2methyl-N-(5-methyl-3isoxolyl-2H-1,2-benzothiazine-3-carboxamide 1,1-dioxide).
Isoxicam is a potent, orally active, nonsteroidal anti-inflammarory drug with prolonged activtiy in experimentally induced inflammation in rats. Isoxicam is less ulcerogenic, acutely less toxic and, therefore, appears to have a therapeutic ratio superior to other standard agents to which it was compared.
D000818:Animals; D000893:Anti-Inflammatory Agents; D001169:Arthritis, Experimental / Q000503:physiopathology; D002351:Carrageenan; D007249:Inflammation / Q000139:chemically induced / Q000503:physiopathology; D007555:Isoxazoles / Q000009:adverse effects / Q000097:blood / Q000494:pharmacology*; D008297:Male; D010080:Oxazoles / Q000494:pharmacology*; D010437:Peptic Ulcer / Q000139:chemically induced; D010894:Piroxicam / Q000031:analogs & derivatives; D051381:Rats; D013843:Thiazines / Q000009:adverse effects / Q000097:blood / Q000494:pharmacology*
D000893:Anti-Inflammatory Agents; D007555:Isoxazoles; D010080:Oxazoles; D013843:Thiazines; D010894:Piroxicam; C013580:isoxicam; D002351:Carrageenan