[The effect of several neurotropic preparations on the differential character of pancreatic enzyme secretion].
Chronic experiments were conducted on dogs with pancreatic fistulae; secretion of the pancreas (basal and stimulated by duodenal perfusion by acid solutions, albumin and its polypeptide hydrolysate) was investigated with consideration to its enzyme (amylase, trypsin, chymotrypsin) secretion. The polypeptide hydrolysate proved to stimulate the pancreatic enzymes more than pure protein. Barbamyl, chlorpromazine and amyzyl inhibited both the basal and the stimulated secretion of the pancreas. The differential character of the pancreatic enzyme secretion was most disturbed by chlorpromazine and amizyl; this served as an evidence of the substantial role of the central adrenergic and cholinergic structures in the adaptation of the pancreatic secretion to food stimuli.
D000654:Amobarbital / Q000494:pharmacology*; D000681:Amylases / Q000378:metabolism; D000818:Animals; D001535:Benactyzine / Q000494:pharmacology*; D002746:Chlorpromazine / Q000494:pharmacology*; D002918:Chymotrypsin / Q000378:metabolism; D003864:Depression, Chemical; D004285:Dogs; D010179:Pancreas / Q000187:drug effects* / Q000378:metabolism; D014357:Trypsin / Q000378:metabolism
D001535:Benactyzine; D000681:Amylases; D002918:Chymotrypsin; D014357:Trypsin; D000654:Amobarbital; D002746:Chlorpromazine
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