title: Studies on metatherian sex chromosomes. I. Inheritance and inactivation of sex-linked allelic genes determining glucose-6-phosphate dehydrogenase variation in kangaroos.
abstract: Wallaroos (Macropus robustus robustus), which have the G6PD-F electrophoretic phenotype, crossed with euros (M.r.erubescens), of G6PD-S phenotype, produced F1 animals which had only the maternal G6PD type regardless of the direction of the cross. When F1 hybrids were backcrossed to wallaroos or euros, backcross progeny of either perental phenotype resulted. Sex-linked inheritance of allelic G6PD genes is shown to occur in wallaroos, euros and red kangaroos (M. rufus). Dose compensation for X chromosomes at the G6PD locus in kangaroow is achieved by inactivation of the allele of male parental origin.
mesh_terms: D000483:Alleles; D000818:Animals; D003433:Crosses, Genetic; D004912:Erythrocytes / Q000201:enzymology; D005260:Female; D005796:Genes; D014644:Genetic Variation; D005954:Glucosephosphate Dehydrogenase / Q000097:blood*; D006824:Hybridization, Genetic; D007614:Macropodidae; D008297:Male; D008394:Marsupialia; D010641:Phenotype; D012730:Sex Chromosomes
chemical_list: D005954:Glucosephosphate Dehydrogenase