Evans blue: a specific inhibitor of factor VIII-induced platelet agglutination.
Low concentrations of Evans Blue (less than 1 muM) inhibit the agglutination of formalin-treated platelets by bovine Factor VIII or by human Factor VIII in the presence of the antibiotic ristocetin. Evans Blue is a specific inhibitor of this reaction and acts by inhibiting the binding of Factor VIII to the platelet surface.
D000244:Adenosine Diphosphate / Q000494:pharmacology; D000818:Animals; D001391:Azo Compounds / Q000494:pharmacology*; D002417:Cattle; D003094:Collagen / Q000494:pharmacology; D005070:Evans Blue / Q000494:pharmacology*; D005169:Factor VIII / Q000037:antagonists & inhibitors*; D006801:Humans; D037102:Lectins / Q000494:pharmacology; D010974:Platelet Aggregation / Q000187:drug effects*; D011107:Polylysine / Q000494:pharmacology; D011485:Protein Binding / Q000187:drug effects; D012310:Ristocetin; D013917:Thrombin
D001391:Azo Compounds; D037102:Lectins; D012310:Ristocetin; D011107:Polylysine; D005070:Evans Blue; D000244:Adenosine Diphosphate; D005169:Factor VIII; D003094:Collagen; D013917:Thrombin