Study of the action of some centrally acting drugs on the EEG and on a conditioned avoidance reflex in the rabbit.
A study was carried out on the effect of perphenazine, diazepam, benactyzine, morphine and a new central analgesic, viminol, onboth EEG and behaviour in rabbits with chronically implanted electrodes trained to a conditioned escape reflex. The results obtained are discussed considering the mechanism and site of action of the different drugs: the experimental procedure adopted is recommended to obtain additional informations on the properties of centrally acting drugs.
D000818:Animals; D001362:Avoidance Learning / Q000187:drug effects* / Q000502:physiology; D001535:Benactyzine / Q000494:pharmacology; D003975:Diazepam / Q000494:pharmacology; D004567:Electrodes, Implanted; D004569:Electroencephalography; D004983:Ethanolamines / Q000494:pharmacology; D008297:Male; D009020:Morphine / Q000494:pharmacology; D010546:Perphenazine / Q000494:pharmacology; D011817:Rabbits; D012018:Reflex / Q000187:drug effects*; D013237:Stereoisomerism
D004983:Ethanolamines; D001535:Benactyzine; D009020:Morphine; D010546:Perphenazine; D003975:Diazepam