title: Changes of molecular properties associated with the development of resistance against methotrexate in human lymphoblastoid cells.
mesh_terms: D000818:Animals; D002460:Cell Line; D004305:Dose-Response Relationship, Drug; D004351:Drug Resistance; D004591:Electrophoresis, Polyacrylamide Gel; D005492:Folic Acid / Q000378:metabolism*; D005574:Formate-Tetrahydrofolate Ligase / Q000378:metabolism; D012696:Glycine Hydroxymethyltransferase / Q000378:metabolism; D006801:Humans; D008228:Lymphoma, Non-Hodgkin / Q000201:enzymology / Q000378:metabolism*; D008727:Methotrexate / Q000378:metabolism / Q000494:pharmacology*; D008754:Methylenetetrahydrofolate Dehydrogenase (NADP) / Q000378:metabolism; D012513:Sarcoma, Experimental / Q000378:metabolism; D013762:Tetrahydrofolate Dehydrogenase / Q000378:metabolism*; D013763:Tetrahydrofolates / Q000378:metabolism; D013937:Thymidine Kinase / Q000378:metabolism; D013940:Thymidylate Synthase / Q000378:metabolism
chemical_list: D013763:Tetrahydrofolates; D005492:Folic Acid; D013762:Tetrahydrofolate Dehydrogenase; D008754:Methylenetetrahydrofolate Dehydrogenase (NADP); D013940:Thymidylate Synthase; D012696:Glycine Hydroxymethyltransferase; D013937:Thymidine Kinase; D005574:Formate-Tetrahydrofolate Ligase; D008727:Methotrexate