title: Chain elongation and desaturation of palmitic acid in liver microsomes of rats subjected to hyperbaric exposure.
abstract: The enzyme activities associated with chain elongation and desaturation of fatty acid in hepatic microsomes from rats held at 1 ATA of air, 1 ATA of He-O2, and 20 ATA of He-O2 were studied. It was found that both the microsomal chain elongation and desaturation of fatty acids were depressed in rats held at 1 ATA of He-O2 as compared to animals held at 1 ATA of air. When animals were exposed to an environment of 20 ATA of He-O2, the chain elongation of fatty acid was about the same as for rats held at 1 ATA of air and was two times greater than for the rats held at 1 ATA of He-O2. The desaturase activity was depressed as compared to the two groups of control animals held at 1 ATA of air and 1 ATA of He-O2.
mesh_terms: D000399:Air Pressure; D000818:Animals; D001274:Atmospheric Pressure; D004242:Diving; D044943:Fatty Acid Desaturases / Q000378:metabolism; D006371:Helium; D008297:Male; D008862:Microsomes, Liver / Q000201:enzymology / Q000378:metabolism*; D010084:Oxidation-Reduction; D010100:Oxygen; D010169:Palmitic Acids / Q000378:metabolism*; D051381:Rats
chemical_list: D010169:Palmitic Acids; D006371:Helium; D044943:Fatty Acid Desaturases; D010100:Oxygen