[Effect of vitamin B6 group on cholesterol and fatty acid biosynthesis (author's transl)].
The effect of vitamin B6 groups, pyridoxine, pyridoxamine, pyridoxal (pyridoxal phosphate and pyridoxal phosphate Ca) on hepatic cholesterol and fatty acid biosynthesis in mice were studied. 1. Acetate-14C incorporation rate into cholesterol and fatty acid in pyridoxal phosphate supplement in vitro increased remarkably, relative to pyridoxine or pyridoxamine. 2. When daily subcutaneous injection of pyridoxal phosphate or pyridoxal phosphate Ca were given to normal mice, pyridoxal phosphate produced the decrease of liver cholesterol biosynthesis and cholesterol levell and the increase of fatty acid biosynthesis and fatty acid level, while pyridoxal phosphate Ca did not produce any significant changes, relative to the normal groups. 3. The dietary cholesterol supplement given pyridoxine fed mice did not produce any changes in liver cholesterol and fatty acid synthesis, and liver cholesterol level, while the increase of liver fatty acid and blood cholesterol biosynthesis were seen. Pyridoxal phosphate Ca plus cholesterol feeding did not produce any changes in liver cholesterol and fatty acid biosynthesis, and liver fatty acid levels and blood cholesterol biosynthesis, while the increase of liver cholesterol leve was seen, relative to the cholesterol fed group.
D000818:Animals; D002784:Cholesterol / Q000096:biosynthesis* / Q000097:blood; D002791:Cholesterol, Dietary / Q000378:metabolism; D005227:Fatty Acids / Q000096:biosynthesis*; D007413:Intestinal Mucosa / Q000378:metabolism; D007668:Kidney / Q000378:metabolism; D008099:Liver / Q000187:drug effects / Q000378:metabolism; D008297:Male; D051379:Mice; D011732:Pyridoxal Phosphate / Q000494:pharmacology; D011733:Pyridoxamine / Q000494:pharmacology; D011736:Pyridoxine / Q000494:pharmacology*
D002791:Cholesterol, Dietary; D005227:Fatty Acids; D011732:Pyridoxal Phosphate; D011733:Pyridoxamine; D002784:Cholesterol; D011736:Pyridoxine