title: [Dicloxacillin: its chemotherapeutic action and experimental kinetic characteristics].
abstract: Activity against 50 clinical staphylococcal strains, chemotherapeutic efficiency, absorption and distribution of dicloxacillin in animals were studied in comparison with oxacillin. It was found that dicloxacillin was superior to oxacillin with respect to a number of their properties. The antibiotic was characterized by a higher antistaphylococcal activity, especially with respect to methicillin resistant strains. It was more effective in treatment of staphylococcal pneumonia and septicopiemia of albino mice. The drug was better absorpted when used orally and was detected in the blood in therapeutic concentrations for long periods of time. The antibacterial titer of the blood serum after dicloxacillin administration was 4 times higher than that of oxacillin.
mesh_terms: D000208:Acute Disease; D000818:Animals; D001682:Biological Availability; D002056:Burns / Q000382:microbiology; D002648:Child; D002908:Chronic Disease; D004009:Dicloxacillin / Q000627:therapeutic use*; D004353:Drug Evaluation, Preclinical; D006801:Humans; D066298:In Vitro Techniques; D007700:Kinetics; D008171:Lung Diseases / Q000382:microbiology; D008712:Methicillin / Q000494:pharmacology; D051379:Mice; D008826:Microbial Sensitivity Tests; D010068:Oxacillin / Q000627:therapeutic use; D010400:Penicillin G / Q000494:pharmacology; D013203:Staphylococcal Infections / Q000188:drug therapy; D013210:Staphylococcus / Q000187:drug effects; D013997:Time Factors
chemical_list: D004009:Dicloxacillin; D010400:Penicillin G; D008712:Methicillin; D010068:Oxacillin
vernacular_title: Dikloksatsillin: khimioterapevticheskoe deĭstvie i osobennosti kineti v éksperimente