[A neurophysiologic analysis of the effect of amidopyrine at the thalamo-cortical level of the somatosensory system].
Acute experiments were conducted on nonanesthetized cats; it was shown that amidopyrin (10, 20 mg/kg, intravenously) decreased the level of the background activity of the thalamic neurons, and, at the same time, increased the amplitude of the focal primary bioelectrical reactions. It is supposed that amidopyrin synchronized evoked reactions of the cells in the thalamus, as well as in the cortex. On the other hand, amidopyrin diminished the excitability of the cortical neurons participating in the interzonal connections.
D000632:Aminopyrine / Q000494:pharmacology*; D000818:Animals; D002415:Cats; D003864:Depression, Chemical; D004558:Electric Stimulation; D009434:Neural Pathways; D011826:Radial Nerve / Q000502:physiology; D013003:Somatosensory Cortex / Q000187:drug effects*; D013787:Thalamic Nuclei / Q000187:drug effects*
D000632:Aminopyrine
Neĭrofiziologicheskiĭ analiz deĭstviia amidopirina na talamo-kortikal'nyĭ uroven'somatosensornoĭ sistemy