Effects of ethanol on the secretion and mucosal blood flow of a denervated gastric pouch in the dog.
Mucosal secretion and blood flow of a Heidenhain pouch were measured in dogs after orally administered ethanol at doses from 0.25 to 2 g/kg of body weight. Under these conditions, the volume, free and total acidity of the gastric juice as well as mucosal blood flow increased linearly with the dose up to 1 g/kg. In all cases volume secreted and acidity chanm the other parameters and could not be correlated with blood flow. The influence of gastrin and the modification of membrane permeability are discussed with regard to these data.
D000818:Animals; D003714:Denervation; D004285:Dogs; D004305:Dose-Response Relationship, Drug; D000431:Ethanol / Q000008:administration & dosage / Q000494:pharmacology*; D005753:Gastric Mucosa / Q000098:blood supply / Q000187:drug effects* / Q000378:metabolism; D012039:Regional Blood Flow / Q000187:drug effects; D013997:Time Factors
D000431:Ethanol