Viscosity and molecular weight of hyaluronic acids.
The intrinsic viscosity ([eta]) and the molecular weight (M) by sedimentation equilibrium were determined for hyaluronic acids of low (M=104--7.2X10(4)) and high (M=3.1X10(5)--1.5X10(6)) molecular weights. Double logarithmic plot of [eta] against M gave different lines for the two groups. The relationship between [eta] and M was [eta]=3.0X10(6)XM1,20 for the former and [eta]=5.7X10(-4)XM0.46 for the latter group. The molecular weight at the point of intersection of the two lines was about 1.5X10(5). The rheological behavior of the hyaluronic acids below M=2.1X10(4), for which the value of reduced viscosity was independent of concentration, was different from that of the hyaluronic acids above M=5.1X10(4), for which the value of reduced viscosity increased with concentration.
D005260:Female; D006595:Hexosamines / Q000032:analysis; D006801:Humans; D006820:Hyaluronic Acid; D008433:Mathematics; D008970:Molecular Weight; D011247:Pregnancy; D011487:Protein Conformation; D014470:Umbilical Cord; D014783:Viscosity
D006595:Hexosamines; D006820:Hyaluronic Acid