title: The dialysis encephalopathy syndrome. Possible aluminum intoxication.
abstract: The aluminum content of muscle, bone and brain was measured in control subjects and in uremic patients on dialysis who had been maintained on phosphate-binding aluminum gels. The mean muscle aluminum was 14.8 ppm, and the trabecular-bone aluminum 98.5 ppm in the patients on dialysis, as compared with 1.2 and 2.4 in control subjects (P less than 0.05). Brain gray-matter aluminum values in a group of uremic patients on dialysis who died of a neurologic syndrome of unknown cause were 25 ppm as compared with 6.5 ppm in a group of uremic patients on dialysis who died of other causes and 2.2 ppm in control subjects. The fact that brain gray-matter aluminum was higher in all patients with the dialysis-associated encephalopathy syndrome than any of the control subjects or other uremic patients on dialysis suggests that this syndrome may be due to aluminum in intoxication.
mesh_terms: D000535:Aluminum / Q000378:metabolism / Q000633:toxicity*; D000536:Aluminum Hydroxide / Q000009:adverse effects; D001842:Bone and Bones / Q000378:metabolism; D001921:Brain / Q000378:metabolism; D001927:Brain Diseases / Q000139:chemically induced*; D006801:Humans; D009132:Muscles / Q000378:metabolism; D006435:Renal Dialysis / Q000009:adverse effects*; D013577:Syndrome; D013997:Time Factors; D014511:Uremia / Q000150:complications / Q000378:metabolism / Q000628:therapy
chemical_list: D000536:Aluminum Hydroxide; D000535:Aluminum