Suprofen, a potent antagonist of acetic acid-induced writhing in rats.
A new standardized acetic acid-induced writhing test in rats is described in detail and its methodology is discussed briefly. The described method has proved to be useful for evaluating the anti-writhing activity of narcotic analgesics, non-narcotic anti-inflammatory compounds and narcotic-antagonists with analgesic activity. A direct quantitative comparison of anti-writhing activity was made between orally administered acetyl-salicylic acid, phenylbutazone, indometacin, tolmetin, ketoprofen and alpha-methyl-4-(2-thienylcarbonyl)benzeneacetic acid (suprofen) in a specially designed experiment. Among the known non-narcotic, non-steroidal anti-inflammatory compounds suprofen appeared to be the most potent antagonist of acetic acid-induced writhing in rats, about 200 to 300 times as potent as acetyl-salicylic acid and phenylbutazone, 15 to 30 times as potent as indometacin and tolmetin, and about 6 times as potent as ketoprofen.
D000085:Acetates; D000700:Analgesics; D000818:Animals; D001095:Arachidonic Acids / Q000378:metabolism; D001241:Aspirin / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D004353:Drug Evaluation, Preclinical; D005260:Female; D007213:Indomethacin / Q000494:pharmacology; D007660:Ketoprofen / Q000494:pharmacology; D008297:Male; D009119:Muscle Contraction / Q000187:drug effects; D010648:Phenylacetates / Q000627:therapeutic use; D010653:Phenylbutazone / Q000494:pharmacology; D010666:Phenylpropionates / Q000494:pharmacology*; D011448:Prostaglandin Antagonists; D011453:Prostaglandins / Q000096:biosynthesis; D051381:Rats; D013035:Spasm / Q000139:chemically induced / Q000188:drug therapy*; D013876:Thiophenes / Q000494:pharmacology* / Q000627:therapeutic use; D014046:Tolmetin / Q000494:pharmacology
D000085:Acetates; D000700:Analgesics; D001095:Arachidonic Acids; D010648:Phenylacetates; D010666:Phenylpropionates; D011448:Prostaglandin Antagonists; D011453:Prostaglandins; D013876:Thiophenes; D007660:Ketoprofen; D014046:Tolmetin; D010653:Phenylbutazone; D001241:Aspirin; D007213:Indomethacin