[Electron microscope study of bacteria in dental plaques following the application of fluorides (author's transl)].
Gels containing fluorides can have profound effects on dental plaques. These gels contain 2% fluorides in the form of sodium monofluorophosphate and sodium fluoride and are buffered to pH 6.5 when applied to teeth they: - encourage the disappearance of certain bacteria, - inhibit the division of cells and diminish their storage of glycogen, - cause a thickening of the bacterial cell wall, - lead to modifications of the bacterial cell membrane, - precipitate the degeneration of most forms of bacteria, - cause the rapid mineralisation of many bacteria. These widespread effects, and the wholesale degeneration of microbial forms, are a reflection of a major breakdown in bacterial metabolism, and provide a partial explanation for the role of fluorides in the prevention of dental caries, and are in accord with previous biochemical and microbial observations.
D000293:Adolescent; D001419:Bacteria / Q000187:drug effects / Q000648:ultrastructure*; D002455:Cell Division / Q000187:drug effects; D002648:Child; D003731:Dental Caries / Q000517:prevention & control; D003773:Dental Plaque / Q000382:microbiology*; D005460:Fluorides, Topical / Q000494:pharmacology / Q000627:therapeutic use*; D006088:Gram-Negative Aerobic Bacteria / Q000187:drug effects / Q000648:ultrastructure; D006801:Humans; D009016:Moraxella / Q000187:drug effects / Q000648:ultrastructure; D012505:Sarcina / Q000187:drug effects / Q000648:ultrastructure
D005460:Fluorides, Topical
Etude ultrastructurale des bactéries des plaques microbiennes dentaires après applications de fluorures