[Course of Trypanosoma musculi infections in NMRI mice (author's transl)].
The trypanosomes multiply during prepatency after minimal infection by a factor of 2.2-3.6 per day. During patency, increase of trypanosome number in the peripheral blood is basically non-logarithmic as the actual proliferating forms remain hidden in special vascular areas (kidney, placenta). The mean increase during patency is approximately linear, typically by 1-10 trypanosomes per 10(4) erythrocytes per day, and depends on the number of infective organisms introduced. - Length of parasitemia is 13-40 days, it is partly determined genetically. Prolonged parasitemias, very low in the later stages, were seen in mice preinfected with Trypanosoma congolense. - In 1 mouse with minimal infection, parasitemia only became patent 63 days after infection under the stress of an added infection with Trypanosoma brucei. - Parasitemia can be terminated by antiserum. Application of antiserum 3 or 4 days after infection may even suppress the development of immunity and priming. - Massive reinfection leads to parasitemia of up to 8 days duration without parasite multiplication.
D000818:Animals; D005260:Female; D007116:Immunization, Passive; D051379:Mice; D008815:Mice, Inbred Strains; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000469:parasitology; D014345:Trypanosoma / Q000254:growth & development*; D014346:Trypanosoma brucei brucei; D014352:Trypanosomiasis / Q000235:genetics / Q000469:parasitology* / Q000628:therapy
Verlauf con Trypanosoma musculi-Infektionen in NMIR-Mäusen