Tumor-inducing effect of trinitroso-trimethylene-triamine (TTT) when orally applied in dimethylsulphoxide (DMSO) for solvent.
By oral application of TTT, disolved in concentrated DMSO, it was possible by means of a long-term experiment to produce tumors in female rats (Wistar strain). Contrary to all previous findings the tumor-inducing effect of this substance has been proved in this way for the first time.
D000284:Administration, Oral; D000588:Amines / Q000008:administration & dosage / Q000009:adverse effects*; D000818:Animals; D002273:Carcinogens; D004121:Dimethyl Sulfoxide; D005260:Female; D008938:Mitosis; D009374:Neoplasms, Experimental / Q000139:chemically induced*; D051381:Rats; D012997:Solvents
D000588:Amines; D002273:Carcinogens; D012997:Solvents; D004121:Dimethyl Sulfoxide