[Experimental study of the relationships between activation of erythropoiesis and hematotoxicity of some antitumoral agents (author's transl)].
The changes in the blood toxicity of some antitumoral chemotherapeutic agents in the presence of erythropoiesis activation by bleeding are evaluated. The general toxicity seems to be unaffected but the damage to erythropoiesis proved, in absolute terms, to be more severe in the bled animals. The recovery of hematopoiesis was slower after some drug than others. These results are discussed in the light of present knowledge of hematopoietic kinetics and of the relationships between antiblastic drugs and staminal hematopoietic compartments.
D000818:Animals; D000970:Antineoplastic Agents / Q000633:toxicity*; D001773:Blood Cells / Q000187:drug effects*; D001815:Bloodletting; D004920:Erythropoiesis / Q000187:drug effects*; D051381:Rats
D000970:Antineoplastic Agents
Ricerce sperimentale sui rapporti tra attivazione eritropoietica ed emotossicità di alcuni antiblastici