DDT and selected analogues as microsomal oxidase inducers in the mouse.
Sixteen DDT-type compounds were tested in the mouse for their ability to induce hepatic microsomal enzymes and cytochrome P-450. Results suggested three categories of inducers: (a) inducers which are metabolized to inducers, (b) temporary inducers which are metabolized to noninducers, and (c) noninducers. Freedom from inductive properties is suggested as a parameter for new microcontaminant chemicals.
D000818:Animals; D003634:DDT / Q000031:analogs & derivatives* / Q000494:pharmacology*; D003633:Dichlorodiphenyl Dichloroethylene / Q000494:pharmacology; D004790:Enzyme Induction / Q000187:drug effects; D051379:Mice; D008815:Mice, Inbred Strains; D008862:Microsomes, Liver / Q000201:enzymology*; D006899:Mixed Function Oxygenases / Q000378:metabolism*; D010088:Oxidoreductases / Q000378:metabolism*
D003633:Dichlorodiphenyl Dichloroethylene; D003634:DDT; D006899:Mixed Function Oxygenases; D010088:Oxidoreductases