Significance of lymphoid atrophy in the pathogenesis of wasting syndrome.
Mice with their lymphoid system made atrophic by neonatal thymectomy, showed increased sensitivity to DAD a lymphotropic cytostatic agent. Wasting syndrome developed earlier and in a higher per cent of neonatally thymectomized mice, when the animals were treated also with the subethal dose of DAD.
D000818:Animals; D001284:Atrophy; D004988:Ethers, Cyclic / Q000494:pharmacology; D006086:Graft vs Host Disease / Q000276:immunology*; D008221:Lymphoid Tissue / Q000473:pathology*; D051379:Mice; D009026:Mortality; D009929:Organ Size; D013154:Spleen / Q000033:anatomy & histology; D013577:Syndrome; D013934:Thymectomy
D004988:Ethers, Cyclic