The formation of poly A-containing RNA in rat liver after administration of 3-methylcholanthrene.
The incorporation of [32P] orthophosphate into liver poly A-rich cytoplasmic RNA was investigated in rats which were pretreated with 3-methyl cholanthrene (3MC) or with the vehicle, corn oil. This incorporation was markedly increased within 6 h after administration of the polycyclic hydrocarbon and reached a maximum by 24 h, i.e., 33-fold increase. The poly A-rich RNA fraction was examined by gel electrophoresis and the specific activity of individual species was shown to be elevated.
D000818:Animals; D003593:Cytoplasm / Q000187:drug effects / Q000378:metabolism; D008099:Liver / Q000187:drug effects / Q000378:metabolism*; D008297:Male; D008970:Molecular Weight; D011061:Poly A / Q000096:biosynthesis*; D012313:RNA / Q000096:biosynthesis*; D051381:Rats; D014158:Transcription, Genetic / Q000187:drug effects*
D011061:Poly A; D012313:RNA