title: Dose-ranging studies of clonazepam in man.
abstract: A potent benzodiazepin derivative, clonazepam, was studied over a range of single doses to determine tolerance for the drug. The best tolerated doses were 0.5 and 1 mg. Higher doses were associated with considerable evidence of sedation, more easily detected by clinical questioning and observation than by commonly used self-reporting scales or motor tests.
mesh_terms: D000328:Adult; D001570:Benzodiazepinones / Q000494:pharmacology*; D002998:Clonazepam / Q000008:administration & dosage / Q000009:adverse effects / Q000494:pharmacology*; D004644:Emotions / Q000187:drug effects; D006801:Humans; D008297:Male; D008875:Middle Aged; D009048:Motor Skills / Q000187:drug effects; D011930:Reaction Time / Q000187:drug effects; D012890:Sleep / Q000187:drug effects; D013997:Time Factors
chemical_list: D001570:Benzodiazepinones; D002998:Clonazepam