Histology of the iris in geese and ducks photosensitized by ingestion of Ammi majus seeds.
Geese and ducks were photosensitized by the ingestion of Ammi majus seeds, and exposure to sunlight. Mydriasis was a characteristic clinical feature of this syndrome in both species. Histologically the iris of the affected birds showed vacuolisation and varying degrees of atrophy of the muscle of the sphincter pupillae. The effect of pilocarpine and physostigmine on the normal and mydriatic eyes was studied. The possible mode of action of photosensitization and the significance of these findings in the light of the use of psoralens in human medicine is discussed.
D000818:Animals; D001284:Atrophy; D003250:Constriction; D004108:Dilatation, Pathologic / Q000139:chemically induced; D004372:Ducks / Q000033:anatomy & histology*; D005777:Geese / Q000033:anatomy & histology*; D007498:Iris / Q000473:pathology*; D019684:Magnoliopsida; D008730:Methoxsalen / Q000506:poisoning*; D009184:Mydriatics / Q000494:pharmacology; D010775:Photic Stimulation; D010830:Physostigmine / Q000494:pharmacology; D010862:Pilocarpine / Q000494:pharmacology; D011680:Pupil / Q000187:drug effects*; D012639:Seeds; D013472:Sunlight
D009184:Mydriatics; D010862:Pilocarpine; D010830:Physostigmine; D008730:Methoxsalen