Some serum biochemical changes associated with chloroform-induced renal tubular necrosis in mice.
The chloroform--induced renal tubular necrosis is associated with the rise of serum urea, creatinine and potassium. The highest values, observed 24 hours after chloroform administration, are respectively: 75 mg% (norm 32 mg%), 1.75 mg% (norm 0.25 mg%), 6.1 mEq/1 (norm 4.4 mEq/1). They gradually decreased with the progress of renal regeneration. These transient, rather little biochemical deviations justify the good conditions and eventual survival of chloroform-poisoned mice. The contribution of possible glomerular lesions to the disturbed renal function is taken into consideration.
D058186:Acute Kidney Injury / Q000139:chemically induced*; D000818:Animals; D002725:Chloroform / Q000008:administration & dosage / Q000009:adverse effects* / Q000097:blood; D003404:Creatinine / Q000097:blood*; D005260:Female; D007668:Kidney / Q000473:pathology; D007683:Kidney Tubular Necrosis, Acute / Q000097:blood / Q000139:chemically induced* / Q000473:pathology; D008297:Male; D051379:Mice; D011188:Potassium / Q000097:blood*; D012737:Sex Factors; D014508:Urea / Q000097:blood*
D002725:Chloroform; D014508:Urea; D003404:Creatinine; D011188:Potassium