title: [Pathomorphological changes in a disease in swine caused by feeding bacterial-contaminated 1-lysine].
abstract: Studied were the lesions in the parenchymal organs and the hormonal glands in 20 pigs spontaneously died as a result of feeding with 1-lysine that had been contaminated with bacteria. The gross changes consisted of the enlargement and dark red coloration of the liver, gastroenteritis, hyperemia and hemorrhages in the kidneys and heart, oedema of the lungs and the wall of the gall bladder. Histologically, in the acute cases the liver showed hyperemia, pericapillary oedema, and granular dystrophia; in the subacute cases there were toxic dystrophy with the activation of the reticulo-endothelial system and subserous oedema in the gall bladder. The kidneys presented hyperemia, hemorrhages, and decreased volume of the glomeruloses in the subacute course of the disease. In terms of their function the heart, lungs, and kidneys displayed hemodynamic disturbances, and in the thyroid there were histologically changes characteristic of a follicular collapse. It is believed that the morphologic changes in the viscera investigated were due not to the intake of lysine itself, but to the effect of toxins produced by the concomitant microflora and the toxic amins (metabolites of the amino acids).
mesh_terms: D000821:Animal Feed; D000818:Animals; D004064:Digestive System / Q000473:pathology; D005516:Food Microbiology; D005517:Foodborne Diseases / Q000473:pathology / Q000662:veterinary*; D005704:Gallbladder / Q000473:pathology; D006470:Hemorrhage / Q000209:etiology; D007668:Kidney / Q000473:pathology; D008099:Liver / Q000473:pathology; D008168:Lung / Q000473:pathology; D008239:Lysine / Q000009:adverse effects*; D009206:Myocardium / Q000473:pathology; D013552:Swine; D013553:Swine Diseases / Q000473:pathology*; D013961:Thyroid Gland / Q000473:pathology
chemical_list: D008239:Lysine
vernacular_title: V'rkhu patomorfologichnite izmeneniia pri zaboliavane na svine, khraneni s's zam'rsen s bakterii techen 1-lizin