Influence of reserpine on high calcium perfusion of thyro-parathyroid glands in dogs.
Perfusion of the thyro-parathyroid glands in the dog with calcium-rich blood led to a significant decrease (P less than 0.001) in the systemic plasma calcium level. On the other hand, injection of reserpine (0.2 mg/kg ip) 16 and 2 h prior to infusion of hypercalcemic blood into thyro-parathyroid glands did not alter the systemic plasma calcium level significantly (P less than 0.05). This result provides evidence that reserpine blocks the release of hypocalcemic factor from the thyro-parathyroid glands in response to perfusion of high concentrations of calcium.
D000818:Animals; D002118:Calcium / Q000097:blood*; D004285:Dogs; D005260:Female; D006934:Hypercalcemia / Q000097:blood; D008297:Male; D010280:Parathyroid Glands / Q000502:physiology*; D010477:Perfusion; D011674:Pulse / Q000187:drug effects; D012110:Reserpine / Q000494:pharmacology*; D013961:Thyroid Gland / Q000502:physiology*
D012110:Reserpine; D002118:Calcium