The effects of testosterone administered neonatally on the incorporation of 3H-leucine into protein by thyroid gland of rat: a neonatal priming.
Rats were castrated on day 2 after birth, given one injection of testosterone pronate (TP: 2.5 mg) or oil just after operation and then received TP or oil when adult. 3H-Leucine was injected intravenously 2.5 hours before killing. The incorporation of labelled amino acid into protein was investigated in the thyroid glands. Males receiving TP both neonatally and when adult incorporate twice as much labelled leucine into protein as compared to their counterparts. Grain density was highest in the thyroid gland of early hormone treated rats when challanged with testosterone in adulthood. Thyroid gland priming by early hormone treatment has been discussed.
D000311:Adrenal Glands; D000818:Animals; D000831:Animals, Newborn; D002369:Castration; D005260:Female; D007930:Leucine / Q000378:metabolism*; D008297:Male; D009929:Organ Size; D010902:Pituitary Gland; D011247:Pregnancy; D011485:Protein Binding; D051381:Rats; D013739:Testosterone / Q000494:pharmacology*; D013961:Thyroid Gland / Q000502:physiology*
D013739:Testosterone; D007930:Leucine