The effect of pharmacological agents on ejaculation.
Infertility in a patient on pharmacological agents with sympatholoytic activity was found to be caused by ejaculatory failure owing to absent contraction of the seminal vesicle, ampulla and ductus deferens, rather than the previously accepted reason of retrograde ejaculation. These findings suggest that pharmacological agents producing alpha-adrenergic blockage may produce temporary interference with ejaculation, suggesting investigation of their use as reversible male contraceptives.
D000328:Adult; D004542:Ejaculation / Q000187:drug effects*; D006145:Guanethidine / Q000494:pharmacology*; D006801:Humans; D008297:Male; D009948:Orgasm; D013881:Thioridazine / Q000494:pharmacology*; D014649:Vas Deferens / Q000294:innervation
D013881:Thioridazine; D006145:Guanethidine