title: [Clinico-pharmacological studies with Nifedipine--a new coronary substance].
abstract: On 19 test persons (10 healthy persons, 9 patients with heart diseases) mechanocardiographic and haemodynamic examinations were carried out with the new preparation Nifedipine (05-072) which effects on the coronary vessels. Insignificant positively inotropic effects with invariable heart rate and cardiac output, decreasing heart action and decreased oxygen consumption were found. Arterial blood pressure and peripheral resistance were only slightly diminished. Own results and reports from literature show that the application of Nifedipine in the ischaemic heart disease appears to be successful.
mesh_terms: D000328:Adult; D001146:Arrhythmia, Sinus / Q000188:drug therapy / Q000503:physiopathology; D001786:Blood Glucose; D001794:Blood Pressure / Q000187:drug effects; D002302:Cardiac Output / Q000187:drug effects; D005260:Female; D006339:Heart Rate / Q000187:drug effects; D006439:Hemodynamics / Q000187:drug effects*; D006801:Humans; D008297:Male; D008875:Middle Aged; D008946:Mitral Valve Stenosis / Q000503:physiopathology; D009543:Nifedipine / Q000494:pharmacology*; D011725:Pyridines / Q000494:pharmacology*; D013997:Time Factors; D014655:Vascular Resistance / Q000187:drug effects
chemical_list: D001786:Blood Glucose; D011725:Pyridines; D009543:Nifedipine
vernacular_title: Klinisch-pharmakologische Untersuchungen mit Nifedipine--einer neuen koronarwirksamen Substanz