Effect of D2O on phytohemagglutinin-induced lymphocyte proliferation.
The effect of D2O on phytohemagglutinin (PHA)-induced proliferation of human lymphocytes in vitro was examined. A significant dose-dependent inhibition of the lymphocyte reactivity by D2O was observed. This inhibition did not require the simultaneous presence of D2O and PHA in the cultures. Both cytotoxic and cytostatic mechanisms for this inhibition are implicated.
D003903:Deuterium / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D006801:Humans; D037102:Lectins / Q000494:pharmacology*; D008213:Lymphocyte Activation / Q000187:drug effects*
D037102:Lectins; D003903:Deuterium