[Ultrastructural changes in the spermatogenic epithelium and in the basic components of the blood-testis barrier in adult rats following repeated administration of estradiol dipropionate].
Electron microscopic studies of the testes were conducted in intact adult Wistar rats and in rats given repeated injections of a 0.1% solution of estradiol-dipropionate-0.3 mg week for 10 weeks. Administration of the hormone caused focal inhibition of spermatogenesis (6 weeks) accompanied by development of destructive changes in the spermatogenic cells. These pathological changes were reversible and disappeared two months after the cessation of the hormone injection, and the spermatogenesis was restored. Development of the pathological changes in the spermatogenic epithelium was accompanied by disturbances of the fine structure of the main components of the blood-test is barrier (Sertoli cells, tunica propria of the seminiferous tubules).
D000818:Animals; D001814:Blood-Testis Barrier / Q000187:drug effects*; D004958:Estradiol / Q000494:pharmacology*; D008297:Male; D051381:Rats; D012670:Seminiferous Epithelium / Q000187:drug effects* / Q000648:ultrastructure; D012671:Seminiferous Tubules / Q000187:drug effects / Q000648:ultrastructure; D012708:Sertoli Cells / Q000187:drug effects / Q000648:ultrastructure; D013737:Testis / Q000187:drug effects*; D013997:Time Factors
D004958:Estradiol
Ul'trastrukturnye izmeneniia v spermatogennom épitelii i osnovnykh komponentakh gemato-testikuliarnogo bar'era u polovozrelykh krys pri povtornom vvedenii éstradiola dipropionata