[The measurement of 75selenium in duodenal juice--an advance in the diagnosis of pancreatic function (author's transl)].
The radioactivity in the duodenal juice following the intravenous injection of 75Se-1-selenomethionine was measured in 17 normal subjects and in 14 patients with exocrine pancreatic insufficiency. The mean values of radioactivity were significantly lower during certain periods of the investigation in the patients with pancreatic insufficiency as compared with the normal subjects. The individual values, however, scattered widely and the standard deviations were large. There was a highly significant correlation between the volume of duodenal juice and the 75Se radioactivity, but no significant correlation was established between the duodenal juice radioactivity and bicarbonate or enzyme concentration i.e. specific parameters of exocrine pancreatic function. It is possible that observation period may bring less equivocal results, but this appears of doubtful practicability. Measurement of the 75Se-1-selenomethione radioactivity in the duodenal juice is only an indirect indicator of exocrine pancreatic function. It does not appear to represent any significant advance in the diagnosis of pancreatic insufficiency, since the information provided by these older-established methods is more reliable and is obtained within a similar space of time.
D002766:Cholecystokinin; D004386:Duodenum / Q000032:analysis*; D006801:Humans; D008722:Methods; D010182:Pancreatic Diseases / Q000175:diagnosis*; D011868:Radioisotopes; D012633:Secretin; D012643:Selenium; D013997:Time Factors
D011868:Radioisotopes; D012633:Secretin; D002766:Cholecystokinin; D012643:Selenium
Die Messung von 75Selen im Duodenalsaft--Eine Bereicherung der Pankreasdiagnostik