title: Local regulation of pulmonary blood flow and ventilation-perfusion ratios in the coatimundi.
abstract: Small catheters (ca. 3 mm diam at tip) were wedged in subsegmental bronchi in anesthetized coatimundi (Nasua nasua) during spontaneous breathing. Mixed expired gases of a group of lobules were sampled continuously without contamination from neighboring units, and local tidal volume, frequency, carbon dioxide production, and oxygen consumption were measured, as well as mixed venous PO2 and PCO2. Local ventilation-perfusion ratio, alveolar PO2, PCO2, and blood flow were calculated. There was a 22% reduction (range 15-38) in local perfusion (as percent of flow at PAO2 100 mmHg) per 10 mmHg fall in local alveolar oxygen tension over the PAO2 range 150-36 mmHg. Local hypercapnia had little effect on local flow. Local tidal volume (ca. 1% of total tidal volume) was unaffected by changes in alveolar gas tensions. The contribution of vasoconstriction or vasodilatation, as a negative feedback system, to the stability of local PAO2 was greatest close to the physiologic range (65-85 mmHg) falloderate efficiency.
mesh_terms: D000818:Animals; D001784:Blood Gas Analysis; D002245:Carbon Dioxide; D002335:Carnivora / Q000502:physiology*; D006935:Hypercapnia; D008170:Lung Compliance; D008433:Mathematics; D010100:Oxygen; D010101:Oxygen Consumption; D011650:Pulmonary Alveoli / Q000502:physiology; D011652:Pulmonary Circulation; D012123:Pulmonary Ventilation; D012126:Respiratory Dead Space; D013990:Tidal Volume; D014692:Ventilation-Perfusion Ratio
chemical_list: D002245:Carbon Dioxide; D010100:Oxygen