[The chemistry of prostaglandins--biosynthesis, metabolism, total syntheses (author's transl)].
Extensive recent research has established that Prostaglandins (PG) are a widespread new class of biomediators. From polyunsaturated fatty acids PGs are formed enzymatically upon a variety of stimuli and then act at low concentrations. Participation has been shown so far for inflammation and pain, gastric secretion, various regulatory functions and others. Total synthesis has been achieved on a number of routes. Structure variations aim at a greater specificity and a less rapid metabolistic breakdown. Therapeutic possibilities are indicated.
D055598:Chemical Phenomena; D002621:Chemistry; D005231:Fatty Acids, Unsaturated / Q000378:metabolism; D006801:Humans; D011448:Prostaglandin Antagonists / Q000378:metabolism; D011453:Prostaglandins / Q000096:biosynthesis / Q000138:chemical synthesis / Q000378:metabolism / Q000502:physiology; D011458:Prostaglandins E; D011460:Prostaglandins F; D013237:Stereoisomerism; D013329:Structure-Activity Relationship
D005231:Fatty Acids, Unsaturated; D011448:Prostaglandin Antagonists; D011453:Prostaglandins; D011458:Prostaglandins E; D011460:Prostaglandins F
Zur Chemie der Prostaglandine--Biogenese, stoffwechsel, Totalsynthese