The possible role of transurethral resection in the dissemination of prostatic cancer.
Prostatic carcinoma often reveals two different forms of tumour growth: (1) vigorous, almost therapy-resistant local growth, with absent or very slow metastasis (group 1), and (2) slight local growth responsive to therapy, combined however with swiftly forming distant metastasis (group 2). Two groups of such patients were examined in relation to primary findings and clinical course. Two factors were found in which they markedly differ. (1) The histological findings: in group 1 significantly more mature cancer forms appeared. (2) TREATMENT: a strikingly higher number of transurethral resections were performed upon in group 2 patient. The difference in the clinical development of prostatic cancer seems to be due to variations in the biology (as yet unknown) but may be partly to operative interference.
D000230:Adenocarcinoma / Q000473:pathology / Q000601:surgery*; D002277:Carcinoma / Q000473:pathology / Q000601:surgery*; D002369:Castration; D004054:Diethylstilbestrol / Q000627:therapeutic use; D006801:Humans; D008207:Lymphatic Metastasis; D008297:Male; D009366:Neoplasm Seeding; D011468:Prostatectomy; D011471:Prostatic Neoplasms / Q000188:drug therapy / Q000473:pathology / Q000601:surgery*; D011879:Radiotherapy Dosage; D014521:Urethra / Q000601:surgery; D014525:Urethral Stricture / Q000601:surgery
D004054:Diethylstilbestrol