Synthetic metabolites of neurohypophyseal hormones. (Des-9-glycinamide)oxytocin and (des-9-glycinamide, des-8-leucine)oxytocin.
Syntheses and biological properties are reported for two analogs of oxytocin in which the glycinamide and the leucylglycinamide moiety, respectively, have been deleted from the parent hormone. Both [des-9-glycinamide]oxytocin and [des-9-glycinamide,des-8-leucine]oxytocin are weak agonists in the rat uterotonic and antidiuretic assays but possess no detectable rat pressor activity. In addition, [des-9-glycinamide]oxytocin is an inhibitor of the oxytocin-induced vasodepressor response in fowl but is a potent agonist in the hydroosmotic assay of the toad urinary bladder.
D000818:Animals; D001001:Anura; D001692:Biological Transport / Q000187:drug effects; D001794:Blood Pressure / Q000187:drug effects; D001834:Body Water / Q000378:metabolism; D002645:Chickens; D004231:Diuresis / Q000187:drug effects; D005260:Female; D066298:In Vitro Techniques; D008297:Male; D009995:Osmosis / Q000187:drug effects; D010121:Oxytocin / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000494:pharmacology; D010909:Pituitary Hormones, Posterior / Q000378:metabolism*; D051381:Rats; D001743:Urinary Bladder / Q000378:metabolism; D014590:Uterine Contraction / Q000187:drug effects
D010909:Pituitary Hormones, Posterior; D010121:Oxytocin