[Experimental results with new radiopharmaceuticals in autochthon brain tumors of rats (author's transl)].
It could be demonstrated by own investigations that ENU-tumors (brain-tumors induced with Ethyl-Nitroso-Urea) are better for clinical questions than the usual transplantation tumors. In this experimental study the temporal and quantitative condition of accumulation of 64Cu-Dimethylglyoxim and 59Fe-Acetyl-Acetone was investigated in rats with ENU-tumors compared with 99mTc-Pertnetate and and 67Ga-Citrate to answer the questions wether 64Cu-Dimethylglyoxim and 59Fe-Acetyl-Acetone are qualified for brain scanning. 64Cu-Dimethylglyoxim and 59Fe-Acetyl-Acetone show like 99mTc-Pertechnetate and 67Ga-Citrate certain affinity to the tumor. At the same time they accumulate in healthy tissues, too. The kinetice of the single radiopharmaceuticals is different. The rates of accumulation of 64Cu-Dimethylglyoxim after 24 hours and of 59Fe-Acetyl Acetone after 4 hours correspond to the rates of accumulation of 99mTc-Pertechnetate after 1 hour. Opposite to this rates of accumulation of 67Ga-Citrate are, because of the high accumulation in the bone, distinctly worse. There are 3 consequences: 1. Brain scintigraphical investigations should not be made with 67Ga-Citrate. 2. Brain scans with 64Cu-Dimethylglyoxim and 59Fe-Acetyl-Acetone will give no better results than scans with 99mTc-Pertechnetate. 3. Further investigations with 64Cu-Dimethylglyoxim and 59Fe-Acetyl-Acetone are not indicated.
D000818:Animals; D001932:Brain Neoplasms / Q000378:metabolism*; D003300:Copper / Q000378:metabolism; D005038:Ethylnitrosourea; D005708:Gallium / Q000378:metabolism; D007504:Iron Radioisotopes / Q000378:metabolism; D008722:Methods; D009374:Neoplasms, Experimental / Q000139:chemically induced; D011868:Radioisotopes / Q000378:metabolism*; D011877:Radionuclide Imaging; D051381:Rats; D013667:Technetium / Q000378:metabolism
D007504:Iron Radioisotopes; D011868:Radioisotopes; D013667:Technetium; D003300:Copper; D005708:Gallium; D005038:Ethylnitrosourea
Experimentelle Ergebnisse mit neuen Radiopharmaka bei autochthonen Hirngeschwülsten der Ratte