Effect of quality and quantity of dietary fat and dimethylhydrazine in colon carcinogenesis in rats.
The effect, quality, and quantity of dietary fat on colon tumor induction by DMH were studied in rats exposed to a given regimen for two generations prior to treatment with DMH. Animals fed a 20% corn oil or 20% lard and treated with DMH had a higher incidence of colonic tumors than did rats fed a 5% corn oil, 5% lard or Purina lab chow and treated similarly. The quality of fat had no major difference on the incidence of colonic tumors.
D000230:Adenocarcinoma / Q000209:etiology*; D000818:Animals; D002277:Carcinoma / Q000209:etiology; D003110:Colonic Neoplasms / Q000139:chemically induced / Q000209:etiology*; D004041:Dietary Fats / Q000009:adverse effects*; D004127:Dimethylhydrazines; D004424:Ear Canal; D004428:Ear Neoplasms / Q000209:etiology; D005260:Female; D006834:Hydrazines; D007414:Intestinal Neoplasms / Q000209:etiology; D007680:Kidney Neoplasms / Q000209:etiology; D009374:Neoplasms, Experimental / Q000139:chemically induced / Q000209:etiology; D051381:Rats
D004041:Dietary Fats; D004127:Dimethylhydrazines; D006834:Hydrazines