[On the behaviour of the main immunoglobulin fractions in the CSF in the course of inflammatory conditions involving the CNS (AUTHOR'S TRANSL)].
Variations of the main immunoglobulin fractions in CSF were studied in 79 children with various inflammatory processes of CNS (purulent and viral meningitis, post-infectious meningoencephalitis, polyradiculoneuritis, etc). This study was extended to a group of non-inflammatory neurological diseases. Increased values of CSF immunoglobulins (especially IgG and IgA) were found in the group of purulent meningitis and in the group of post-infectious meningoencephalitis. IgM was detected in very few cases. Generally, a correlation was observed between highest concentrations of CSF immunoglobulins and degree of meningeal inflammatory response, even if this was a component of other neurological diseases. It is suggested that the rise of CSF IgG and IgA may depend upon the CSF-blood barrier damage, as it occurs in most inflammatory diseases studied. On the contrary, a production "in situ" of CNS could explain the presence of cerebrospinal IgM.
D000917:Antibody Formation; D002490:Central Nervous System; D002493:Central Nervous System Diseases / Q000276:immunology*; D002555:Cerebrospinal Fluid; D002648:Child; D002675:Child, Preschool; D006801:Humans; D007070:Immunoglobulin A / Q000302:isolation & purification; D007128:Immunoglobulin Fragments / Q000134:cerebrospinal fluid*; D007074:Immunoglobulin G / Q000302:isolation & purification; D007223:Infant; D008581:Meningitis / Q000276:immunology; D008587:Meningitis, Viral / Q000276:immunology; D008590:Meningoencephalitis / Q000276:immunology; D011128:Polyradiculopathy / Q000276:immunology
D007070:Immunoglobulin A; D007128:Immunoglobulin Fragments; D007074:Immunoglobulin G
Sul comportamento delle principali frazioni immunoglobuline nel liquor cefalo-rachidiano nel corso di processi patologici, prevalentemente infiammatori del sistema nervoso centrale