[Influence of antacids on plasma concentration of digoxin in man (author's transl)].
In a cross-over trial the plasma concentrations of digoxin have been studied in nine healthy subjects given oral doses of digoxin alone and simultaneoulsy with magnesium-aluminium-silicate-hydrate and dimagnesium-aluminium-trisilicate. The administration of 0.75 mg digoxin on each of 3 days and 0.375 mg on each of 2 days caused a 17 percent decrease of digoxin plasma level when given simultaneously with 1100 mg magnesium-aluminium-silicate-hydrate (n=4) and a 24 percent increase when given with 1000 mg dimagnesium-aluminium-trisilicate (n=5), respectively. The differences are not significant. The experiments suggested that antacids containing magnesium-aluminium-silicate do not impair the absorption of digoxin in man.
D000284:Administration, Oral; D000328:Adult; D000863:Antacids / Q000494:pharmacology*; D004077:Digoxin / Q000008:administration & dosage / Q000097:blood* / Q000378:metabolism; D005260:Female; D006801:Humans; D007408:Intestinal Absorption / Q000187:drug effects; D008297:Male
D000863:Antacids; D004077:Digoxin
Der Einfluss von Antacida auf die Plasmakonzentration von Digoxin beim Menschen