The effects of propranolol on the bronchoconstriction by histamine, acetyl-beta-methylcholine and anaphylaxis in inbred guinea pigs in vivo.
Propranolol enhanced the anaphylaxis reaction more than the reaction to histamine and mecholyl in inbred strain guinea pigs. These results suggest the presence of beta receptors on mast cells and that there are genetic differences in the reaction to mediators and antigens among these strains of guinea pigs.
D000818:Animals; D000937:Antigen-Antibody Reactions / Q000187:drug effects; D001980:Bronchi / Q000187:drug effects* / Q000276:immunology; D005260:Female; D005796:Genes; D006168:Guinea Pigs; D006632:Histamine; D008297:Male; D008688:Methacholine Compounds; D010323:Passive Cutaneous Anaphylaxis / Q000187:drug effects*; D011107:Polylysine; D011433:Propranolol / Q000494:pharmacology*; D011941:Receptors, Adrenergic / Q000187:drug effects; D013045:Species Specificity; D013997:Time Factors
D008688:Methacholine Compounds; D011941:Receptors, Adrenergic; D011107:Polylysine; D006632:Histamine; D011433:Propranolol