[Ultrastructure and plastic metabolism of the myocardium in allergic lesion of the heart].
Allergic damage was induced in the hearts of senstized rabbits by way of slow intravenous injections of permissible doses of an antigen. One to 20 days after such a weakened anaphylactic reaction of the walls of the left auriculum were examined by light and electron microscopy. After one day, the histological studies revealed in all layers of the ventricle and auriculum oedematous and discirculatory manifestations, and electron microscopy demonstrated a complex of reversible sub-microscopic changes in the myocytes of the myocardium, their contractile organells being damaged predominantly. The biochemical studies permitted to reveal an activation of the decomposition of the myocardial myofibrillar proteins that was not accompanied by a proportional decomposition of the sarcoplasmic and connective-tissue proteins. The inner architecture of the myocytes was restored at the expense of the intracellular regenerative processes with transient hyperplasia of the intracellular regenerative processes with transient hyperplasia of the protein synthesizing organells of the myocytes.
D000707:Anaphylaxis / Q000473:pathology*; D000818:Animals; D003238:Connective Tissue / Q000378:metabolism; D008297:Male; D008854:Microscopy, Electron; D008931:Mitochondria, Muscle / Q000378:metabolism; D009124:Muscle Proteins / Q000378:metabolism*; D009206:Myocardium / Q000378:metabolism / Q000473:pathology* / Q000648:ultrastructure; D009210:Myofibrils / Q000378:metabolism; D011817:Rabbits; D012214:Rheumatic Heart Disease / Q000209:etiology; D012519:Sarcoplasmic Reticulum / Q000378:metabolism
D009124:Muscle Proteins
Ul'trastruktura i plasticheskiĭ obmen miokarda pri allergicheskom povrezhdenii serdtsa