title: Antiinflammatory activity of some 2,3-dihydrobenzofuran-5-acetic acids and related compounds.
abstract: A series of 2,3-dihydrobenzofuran-5-acetic acids and related compounds was prepared as potential antiinflammatory agents. As measured by the carrageenan-induced edema method for the preliminary screening test, introduction of a methyl group alpha to the acetic acid function enhanced the antiinflammatory activity, and alpha-(7-chloro-2,2-dimethyl-2,3-dihydrobenzofuran)-alpha-methyl-5-acetic acid (13a) showed the most potent activity in this series.
mesh_terms: D000085:Acetates / Q000138:chemical synthesis / Q000627:therapeutic use; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000138:chemical synthesis* / Q000627:therapeutic use; D001572:Benzofurans / Q000138:chemical synthesis* / Q000627:therapeutic use; D002351:Carrageenan; D004487:Edema / Q000139:chemically induced / Q000188:drug therapy; D005753:Gastric Mucosa; D007249:Inflammation / Q000188:drug therapy; D008297:Male; D051381:Rats; D013329:Structure-Activity Relationship
chemical_list: D000085:Acetates; D000893:Anti-Inflammatory Agents; D001572:Benzofurans; D002351:Carrageenan