Influence of parental lead exposure on subsequent learning ability of offspring.
This study was designed to assess the learning ability of rat offspring following the exposure of one or both parents to lead acetate (Pb) from 30-90 days of age. At that time, parents were mated to yield four groups: Group Pb-Pb, both parents had received Pb; Group Pb-N, only the mother had received Pb; Group N-Pb, only the father had received Pb; Group N-N, the control parents. Mothers were continued on their respective treatments throughout gestation and nursing. Testing of offspring began at 30 days of age, employing a black-white discrimination water T maze. Analysis of results revealed that the three Pb groups made more errors than the controls, but did not differ from one another. However, offspring in Group Pb-Pb had longer swimming times than those in Groups Pb-N and N-Pb, who, in turn, had longer swimming times than Group N-N. Thus dual parental exposure was more severe than single parental exposure, which, however, still exerted a detrimental effect compared to control performance.
D000818:Animals; D001835:Body Weight / Q000187:drug effects; D004193:Discrimination Learning / Q000187:drug effects; D004924:Escape Reaction / Q000187:drug effects; D005260:Female; D007774:Lactation; D007854:Lead / Q000494:pharmacology*; D007858:Learning / Q000187:drug effects*; D008297:Male; D008431:Maternal-Fetal Exchange; D011247:Pregnancy; D051381:Rats; D011919:Rats, Inbred Strains; D011930:Reaction Time / Q000187:drug effects; D013550:Swimming; D013997:Time Factors
D007854:Lead