[Serotonin uptake by human thrombocytes as a method of screening antidepressants].
Imipromine-like antidepressants (10(-7)--10(-5) M) significantly inhibited the uptake of serotonin by the human blood platelets. Among the neuroleptics haloperidol alone depressed the uptake of serotonin in the concentration of 10(-5) M. Amphetamine and cholinolytics failed to affect the uptake of serotonin even in a concentration of 10(-4) M. The data obtained supported the hypothesis on mediation of the thymoanaleptic action through the intensification of the central serotoninergic processes. Serotonin uptake by the human blood platelets can be used for screening the antidepressants.
D000042:Absorption; D000928:Antidepressive Agents / Q000032:analysis / Q000494:pharmacology / Q000592:standards*; D001792:Blood Platelets / Q000378:metabolism*; D006801:Humans; D012701:Serotonin / Q000378:metabolism*
D000928:Antidepressive Agents; D012701:Serotonin
Pogloshchenie serotonina trombotsitami cheloveka kak metodika skrininga antidepressantov