Levamisole treatment of local and metastatic growth of transplanted rat tumours.
Levamisole has been examined for its ability to control local growth and pulmonary metastases of transplanted rat tumours. The compound did not suppress subcutaneous growth of 3-methylcholanthrene induced sarcomata when administered systemically in a variety of regimens, or when injected in admixture with tumour cells. In addition, levamisole treatment failed to suppress pulmonary growth of intravenously transferred sarcoma cells or spontaneous pulmonary metastases appearing after surgical removal of a transplanted epithelioma.
D000818:Animals; D000951:Antigens, Neoplasm; D007978:Levamisole / Q000627:therapeutic use*; D008175:Lung Neoplasms / Q000517:prevention & control; D008748:Methylcholanthrene; D009362:Neoplasm Metastasis; D009368:Neoplasm Transplantation; D051381:Rats; D012513:Sarcoma, Experimental / Q000139:chemically induced / Q000188:drug therapy* / Q000601:surgery; D014184:Transplantation, Homologous
D000951:Antigens, Neoplasm; D007978:Levamisole; D008748:Methylcholanthrene