[Extraction and characterization of a gastrosecretagogue peptide from the pancreas (author's transl)].
A peptide which stimulates gastric acid secretion in the rat has been isolated from the normal porcine pancreas. It consists of 13 amino acids and has a molecular weight of 1286. It has been named GSP (gastrosecretagogue pancreatic peptide) on account of its main biological activity. Although its influence on gastric acid secretion is gastrin-like, there are marked biochemical and immunological differences between gastrin and GSP. The two substances are separable from each other by Sephadex gel filtration, by ion-exchange chromatography, and by disc electrophoresis. Furthermore, there are differences in the UV-absorption spectrum and in the amino acid composition. GSP does not react with gastrin antibodies in a radioimmunological system. GSP is considered to be a new polypeptide hormone by means of which the pancreas plays a role in the regulation of gastric acid secretion.
D000596:Amino Acids / Q000032:analysis; D000818:Animals; D001646:Bile / Q000378:metabolism; D002850:Chromatography, Gel; D005745:Gastric Acidity Determination; D005750:Gastric Juice / Q000378:metabolism; D005755:Gastrins / Q000502:physiology; D010179:Pancreas / Q000032:analysis*; D010455:Peptides / Q000032:analysis / Q000302:isolation & purification* / Q000502:physiology; D013552:Swine
D000596:Amino Acids; D005755:Gastrins; D010455:Peptides
Extraktion und Charakterisierung eines gastrosekretagogen Peptids aus dem Pankreas