Effects of acute administration of taurocholic and taurochenodeoxycholic acid on biliary lipid excretion in the rat.
Comparison of the effects of biliary lipid excretion produced by infusion of taurochenodeoxycholate and taurocholate showed no significant difference when the bile acids were infused for a relatively short period of time. Cholesterol excretion rates measured during depletion of the bile acid pool were significantly higher than cholesterol excretion rates measured during infusion of bile acids at various rates. These data indicate that there is some mechanism in addition to bile acid excretion that is responsible for biliary excretion of cholesterol when the enterohepatic circulation is intact.
D000818:Animals; D001646:Bile / Q000378:metabolism*; D001647:Bile Acids and Salts / Q000378:metabolism; D002635:Chenodeoxycholic Acid / Q000031:analogs & derivatives* / Q000494:pharmacology; D002784:Cholesterol / Q000378:metabolism*; D010743:Phospholipids / Q000378:metabolism*; D051381:Rats; D013654:Taurine / Q000031:analogs & derivatives; D013656:Taurocholic Acid / Q000494:pharmacology*
D001647:Bile Acids and Salts; D010743:Phospholipids; D002635:Chenodeoxycholic Acid; D013654:Taurine; D013656:Taurocholic Acid; D002784:Cholesterol