[Cholesterol 7alpha-hydroxylase activity of the rat liver after hypophysectomy and administration of hypophyseal hormones (author's transl)].
In order to elucidate the role of the hypophysis in the regulation of cholesterol 7alpha-hydroxylase activity, male and female rats hypophysectomized on day 50 of life were treated with different hypophyseal hormones and tested on day 85 of life. Only a crude extract from human hypophysis and ovine prolactin was able to enhance the enzyme activity, thereby restoring the level of intact controls.
D000818:Animals; D002790:Cholesterol 7-alpha-Hydroxylase / Q000032:analysis*; D002940:Circadian Rhythm; D005260:Female; D006801:Humans; D008099:Liver / Q000187:drug effects / Q000201:enzymology*; D008297:Male; D010902:Pituitary Gland / Q000502:physiology*; D011388:Prolactin / Q000494:pharmacology; D051381:Rats; D013250:Steroid Hydroxylases / Q000032:analysis*; D014020:Tissue Extracts / Q000494:pharmacology
D014020:Tissue Extracts; D011388:Prolactin; D013250:Steroid Hydroxylases; D002790:Cholesterol 7-alpha-Hydroxylase
Die Cholesterin-7alpha-Hydroxylase-Aktivität der Rattenleber nach Hypophysektomie und nach Substitution mit Hypophysenhormonen