title: Topical hemostatic agents to reduce bleeding from cancellous bone. A comparison of microcrystalline collagen, thrombin, and thrombin-soaked gelatin foam.
abstract: In fifty-three dogs microcrystalline collagen, thrombin-soaked gelatin foam, and thrombin powder were evaluated as hemostatic agents when applied to bleeding cancellous surfaces after osteotomy of the greater trochanter using two quantitative models: one, a single osteotomy; the other, a double osteotomy. All three agents significantly reduced bleeding compared with the controls, the microcrystalline collagen being most effective. At three months there was no evidence that microcrystalline collagen and thrombin-gelatin interfered with bone healing after the greater trochanter was reattached with two wires.
mesh_terms: D000287:Administration, Topical; D000818:Animals; D001847:Bone Diseases / Q000188:drug therapy*; D003094:Collagen / Q000008:administration & dosage / Q000627:therapeutic use; D004195:Disease Models, Animal; D004285:Dogs; D005781:Gelatin Sponge, Absorbable / Q000008:administration & dosage / Q000627:therapeutic use; D006470:Hemorrhage / Q000188:drug therapy*; D006490:Hemostatics / Q000008:administration & dosage / Q000627:therapeutic use*; D010027:Osteotomy; D013917:Thrombin / Q000008:administration & dosage / Q000627:therapeutic use
chemical_list: D006490:Hemostatics; D003094:Collagen; D013917:Thrombin