title: [Biochemical genetics of erythrocyte arylesterase in karakul sheep].
abstract: Three zones of esterase activity were established in zymograms of erythrocyte lysates in karakul sheep by means of starch gel electrophoresis. These zones were distinguished according to their substrate specificity and inhibition tests and desnguated as arylesterase (I), carbonic anhydrase (II) and aliesterase (III). The following phenotypes of erythrocyte arylesterase were distinguished in the two populations of karakul sheep studied: AEs - A, AEs - AB, AEs - AC, AEs - AD, AEs - B, AEs - BC, AEs - BD, AEs - C, AEs - CD, AEs - D. These phenotypes are controlled by 4 dominant alleles, VIZ. AEsA, AEsB, AEsC, AEsD. Gene frequencies vary from population to population: from 0.012 +/- 0.005 to 0.118 +/- 0.027, from 0.331 +/- 0.021 to 0.340 +/- 0.012, from 0.601 +/- 0.022 to 0.250 +/- 0.011 and from 0.056 +/- 0.003 to 0.292 +/- 0.011 for AEsA, AEsB, AEsC and AEsD respectively. The actually observed distribution of arylesterase phenotypes is in accordance with the theoretically expected values (p is less than 0.95).
mesh_terms: D000483:Alleles; D000818:Animals; D002265:Carboxylic Ester Hydrolases / Q000037:antagonists & inhibitors / Q000378:metabolism*; D002802:Cholinesterases; D004912:Erythrocytes / Q000201:enzymology*; D005787:Gene Frequency; D011110:Polymorphism, Genetic; D012756:Sheep; D013045:Species Specificity
chemical_list: D002265:Carboxylic Ester Hydrolases; D002802:Cholinesterases
vernacular_title: Biokhimicheskaia genetika éritrotsitarnoĭ arilésterazy karakul'skikh ovets