Ferrihemoglobin and kidney lesions in rats produced by 4-aminophenol or 4-dimethylaminophenol.
4-Dimethylaminophenol hydrochloride (DMAP), 20mg/kg i.v., was found to oxidize in rats as much as 50% of the hemoglobin to ferrihemoglobin but did not cause kidney lesions. 4-Aminophenol hydrochloride, 400 mg/kg i.v., oxidized only 25% of the hemoglobin and produced large tubular necroses. In highly toxic doses only, e.g., twice the LD50, DMAP also produced tubular necroses.
D000818:Animals; D000931:Antidotes; D003486:Cyanides / Q000506:poisoning; D004305:Dose-Response Relationship, Drug; D006029:Glycosuria / Q000139:chemically induced; D007674:Kidney Diseases / Q000139:chemically induced*; D007928:Lethal Dose 50; D008297:Male; D008706:Methemoglobin / Q000096:biosynthesis*; D010636:Phenols / Q000633:toxicity*; D051381:Rats
D000931:Antidotes; D003486:Cyanides; D010636:Phenols; D008706:Methemoglobin