[Radioimmunologic studies on serum gonadotropic hormones during oral contraception].
In 10 women serum FSH- and LH-concentrations (radioimmunoassay) were measured daily throughout a complete cycle. 2 patients exhibited untreated biphasic menstrual cycles. 2 women were under the treatment of a combined estrogen - progestagen preparation, 1 woman was taking a sequential preparation, and 5 patients were treated with a weekly dose of a recently developed depot - estrogen (ethinylestradiolsulfonate). While the untreated women showed typical serum FSH-and LH-patterns characteristic of the biphasic menstrual cycle, patients on combined therapy were found to have a continuous low FSH- and LH-level except in the postmenstrual phase of the cycle, in which the values were slightly elevated. Serum-FSH-concentration in the woman on the sequential preparation remained constant throughout the treatment peroid, while serum LH-pattern showed multiple peaks. In the same manner, serum LH-patterns in women on the weekly depot- estrogen regimen were characterized by nearly regularly appearing LH-peaks, which seemed to be correlated with the estrogen intake. The cause and clinical significance of these findings are discussed.
D003276:Contraceptives, Oral / Q000008:administration & dosage*; D003279:Contraceptives, Oral, Sequential / Q000008:administration & dosage; D004997:Ethinyl Estradiol / Q000008:administration & dosage; D005260:Female; D005640:Follicle Stimulating Hormone / Q000097:blood; D006065:Gonadotropins, Pituitary / Q000097:blood*; D006801:Humans; D007986:Luteinizing Hormone / Q000097:blood; D008598:Menstruation
D003276:Contraceptives, Oral; D003279:Contraceptives, Oral, Sequential; D006065:Gonadotropins, Pituitary; D004997:Ethinyl Estradiol; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone
Radioimmunologische Untersuchungen der gonadotropen Hormone im Serum unter hormonaler Kontrazeption