The effects of polyamines on cardiac protein biosynthesis.
Putrescine, spermine, and spermidine were able to stimulate cell-free protein biosynthesis at low Mg++ ion concentrations. The addition of polyamines to the perfusate of an isolated perfused rat heart preparation caused an increased rate of [14C]phenylalanine incorporation into myocardial protein. Spermine increased the uptake of alpha-aminoisobutyric acid into the myocardium.
D000621:Aminoisobutyric Acids / Q000378:metabolism; D000818:Animals; D001692:Biological Transport; D002462:Cell Membrane / Q000187:drug effects / Q000378:metabolism; D002474:Cell-Free System; D066298:In Vitro Techniques; D008274:Magnesium / Q000494:pharmacology; D009124:Muscle Proteins / Q000096:biosynthesis; D009206:Myocardium / Q000378:metabolism*; D010477:Perfusion; D010649:Phenylalanine / Q000378:metabolism; D011073:Polyamines / Q000494:pharmacology*; D014176:Protein Biosynthesis / Q000187:drug effects*; D011700:Putrescine / Q000494:pharmacology; D051381:Rats; D013095:Spermidine / Q000494:pharmacology; D013096:Spermine / Q000494:pharmacology
D000621:Aminoisobutyric Acids; D009124:Muscle Proteins; D011073:Polyamines; D013096:Spermine; D010649:Phenylalanine; D008274:Magnesium; D013095:Spermidine; D011700:Putrescine