Immunosuppressive activity of concanavalin A.
Daily intraperitoneal doses of concanavalin A (Con A) produced a dose-related inhibition of adjuvant-induced arthritis in rats. Con A was also effective on established arthritis, markedly relieving the disease after only three doses. The inhibitory effect of Con A was neutralised by pre-incubation with ovalbumin, although this treatment did not modify the delayed phlogistic action of Con A in rat paws.
D000818:Animals; D001172:Arthritis, Rheumatoid / Q000188:drug therapy*; D003208:Concanavalin A / Q000009:adverse effects / Q000378:metabolism / Q000627:therapeutic use*; D004305:Dose-Response Relationship, Drug; D004487:Edema / Q000139:chemically induced; D005260:Female; D005528:Foot; D006614:Hindlimb; D007166:Immunosuppressive Agents / Q000627:therapeutic use*; D010047:Ovalbumin / Q000378:metabolism; D051381:Rats; D013997:Time Factors
D007166:Immunosuppressive Agents; D003208:Concanavalin A; D010047:Ovalbumin