Innervation of hypothalamic and limbic areas by the cholinergic, the GABA-ergic and the catecholaminergic nerve fibers; a quantitative analysis.
By measuring activities of enzymes involved in synthesis of acetylcholine, gamma-aminobutyric acid (GABA), dopamine or noradrenaline, extent of innervation of cholinergic, GABA-ergic, dopaminergic and noradrenergic fibers were analysed in discrete brain areas and subareas of the baboon and the rabbit with a special reference to the hypothalamus and the preoptic ares. In the latter area, cholinergic and dopaminergic innervation increases medio-lateraly on the one hand, and noradrenergic innervation reversed on the other hand. GABA-ergic innervation is almost evenly distributed in this structure. By placing electrical lesions in the lateral hypothalamus, an analysis was made of inputs of these innervations.
D000110:Acetylcholinesterase / Q000378:metabolism*; D000123:Acetyltransferases / Q000378:metabolism*; D000818:Animals; D001921:Brain / Q000201:enzymology*; D002262:Carboxy-Lyases / Q000378:metabolism*; D002795:Choline O-Acetyltransferase / Q000378:metabolism*; D004299:Dopamine beta-Hydroxylase / Q000378:metabolism; D005968:Glutamate Decarboxylase / Q000378:metabolism*; D007031:Hypothalamus / Q000201:enzymology / Q000502:physiology*; D008032:Limbic System / Q000201:enzymology / Q000502:physiology*; D008297:Male; D009928:Organ Specificity; D010215:Papio; D011301:Preoptic Area / Q000201:enzymology; D011817:Rabbits; D013045:Species Specificity; D013788:Thalamus / Q000201:enzymology
D004299:Dopamine beta-Hydroxylase; D000123:Acetyltransferases; D002795:Choline O-Acetyltransferase; D000110:Acetylcholinesterase; D002262:Carboxy-Lyases; D005968:Glutamate Decarboxylase