title: Dose size and dosing interval determination.
abstract: Knowing the necessary minimum inhibitory or minimum effective concentration of a drug dose size and/or dosing interval for multiple dose therapy can be calculated under the assumption that the blood level-time curve of a drug can be described by an open one-compartment or an open two-compartment model, that the drug does not show dose dependent pharmacokinetics for the therapeutic dose range and that the distribution coefficient is applicable for a wide body weight range and age group, excluding severe edemas and obesity. The dose size and dosing interval equations are derived from the minimum blood-level concentration c'min equation in multiple dosing. Substituting c'min by MIC or MEC, cop by D - f/Vd and Vd by delta' - BW either the required dose size or dosing interval can be calculated. In the case of renal failure adjustment can be made by inclusion of a correction factor into the equations using either the observed creatinine clearance or the serum creatinine value.
mesh_terms: D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000368:Aged; D001835:Body Weight; D002648:Child; D002675:Child, Preschool; D003404:Creatinine / Q000032:analysis / Q000378:metabolism; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D004358:Drug Therapy; D005260:Female; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007676:Kidney Failure, Chronic / Q000188:drug therapy; D007700:Kinetics; D008297:Male; D008433:Mathematics; D008875:Middle Aged; D008954:Models, Biological; D004364:Pharmaceutical Preparations / Q000097:blood / Q000378:metabolism; D011485:Protein Binding; D013997:Time Factors
chemical_list: D004364:Pharmaceutical Preparations; D003404:Creatinine