[On a special form of extremity malformation in rats following administration of 6-mercaptopurine on day 12 of gestation (author's transl)].
After i.p. application of 16 or 25 mg/kg, resp., 6-mercaptopurine on day 12 of gestation, numerous bone aplasias in the extremities can be demonstrated using the alizarine-red clearing method or X-ray techniques. In a few cases, however, histological examination reveals the presence of an unmineralized cartilagenous skeletal piece. The cause of this malformation is presumably the damaging of precursor cells of the osteoblasts responsible for the desmal and enchondral esteogenesis during the blastema stage. Therefore, it is to be distinguished between the true and the cartilagenous aplasias.
D000014:Abnormalities, Drug-Induced; D000818:Animals; D001846:Bone Development; D004305:Dose-Response Relationship, Drug; D005121:Extremities / Q000196:embryology; D005260:Female; D005360:Fibula / Q000002:abnormalities; D005552:Forelimb / Q000002:abnormalities; D006614:Hindlimb / Q000002:abnormalities; D015122:Mercaptopurine / Q000009:adverse effects*; D011247:Pregnancy; D051381:Rats; D013723:Teratogens; D013977:Tibia / Q000002:abnormalities
D013723:Teratogens; D015122:Mercaptopurine
Uber eine besondere Form von Extremitätenmissbildung bei Ratten nach Gaben von 6-Mercaptopurin am Tag 12 der Schwangerschaft