Delivery of di-2-ethylhexyl phthalate to patients during hemodialysis.
It has been determined that the plasticizer di-2-ethylhexylphthalate (DEHP) can be leached from plastic bags used to store blood. During hemodialysis patient's blood is in contact with various plastic tubings; thus, studies were undertaken to determine how much, if any, DEHP was delivered into patients undergoing hemodialysis. Serial arterial and venous blood samples were drawn into glass syringes; serum was separated in acid-washed glass test tubes and stored at -80 degrees C. until analyzed for DEHP by gas-liquid chromatography. DEHP was delivered to each of nine patients studied. The amount delivered increased with the length of dialysis, up to 150 mg. during a 5-hour hemodialysis. The metabolic fate and toxicity, if any, of infused DEHP remains to be determined.
D058186:Acute Kidney Injury / Q000628:therapy; D001793:Blood Preservation / Q000295:instrumentation*; D004051:Diethylhexyl Phthalate / Q000008:administration & dosage / Q000097:blood*; D004209:Disposable Equipment; D006801:Humans; D007676:Kidney Failure, Chronic / Q000628:therapy; D010795:Phthalic Acids / Q000097:blood*; D010969:Plastics; D006435:Renal Dialysis
D010795:Phthalic Acids; D010969:Plastics; D004051:Diethylhexyl Phthalate