Pathogenesis of spike-wave status: a clinical-pathological study implicating cerebellar disturbance.
If cerebellar Purkinje cells function in a manner so as to terminate at least some types of seizures or to prevent their clinical development then loss of Purkinje cells should predispose to the prolonged or continuous occurance of these seizures. This study presents clinical data that may document such an instance and cites the supporting experimental data.
D002531:Cerebellum / Q000473:pathology / Q000503:physiopathology*; D002540:Cerebral Cortex / Q000473:pathology; D004827:Epilepsy / Q000503:physiopathology*; D006801:Humans; D002534:Hypoxia, Brain / Q000473:pathology / Q000503:physiopathology*; D008297:Male; D008875:Middle Aged; D011689:Purkinje Cells / Q000473:pathology; D013787:Thalamic Nuclei / Q000473:pathology