Effect of peptichemio exposure on DNA synthesis in a mammalian cell system in vitro.
The effect of Peptichemio (PTC) on the survival and DNA synthesis in mouse L-cells was studied. Experimental data show that a typical dose-survival curve is obtained when L-cells are cultivated in the presence of PTC. Exposure of L-cells to various concentrations of PTC caused an inhibition in cellular ability to synthesize DNA which is evidenced by the decreased incorporation of 3H-thymidine. This inhibition is dependent on the concentration of PTC and the time of exposure.
D000818:Animals; D004247:DNA / Q000096:biosynthesis*; D066298:In Vitro Techniques; D007739:L Cells / Q000187:drug effects* / Q000378:metabolism; D051379:Mice; D009588:Nitrogen Mustard Compounds / Q000494:pharmacology*; D010440:Peptichemio / Q000494:pharmacology*; D013936:Thymidine / Q000378:metabolism; D014316:Tritium
D009588:Nitrogen Mustard Compounds; D014316:Tritium; D004247:DNA; D010440:Peptichemio; D013936:Thymidine