Renal handling of iodamide and diatrizoate. Evidence of active tubular secretion of iodamide.
Active tubular secretion of iodamide, a water-soluble contrast medium, was demonstrated by comparing the clearances of iodamide, iothalamate and inulin. Passive tubular back diffusion was not found. The fraction excreted by tubular secretion was significantly reduced at "clinical" plasma concentrations. The glomerular filtration rate was slightly depressed at these concentrations of iodamide and diatrizoate.
D000293:Adolescent; D000328:Adult; D000368:Aged; D001798:Blood Proteins / Q000378:metabolism; D003973:Diatrizoate / Q000378:metabolism*; D004305:Dose-Response Relationship, Drug; D005260:Female; D005919:Glomerular Filtration Rate; D006801:Humans; D007328:Insulin / Q000378:metabolism; D007451:Iodamide / Q000378:metabolism*; D007463:Iodobenzoates / Q000378:metabolism*; D007483:Iothalamic Acid / Q000378:metabolism; D007684:Kidney Tubules / Q000378:metabolism*; D008297:Male; D008657:Metabolic Clearance Rate; D008875:Middle Aged; D011485:Protein Binding
D001798:Blood Proteins; D007328:Insulin; D007463:Iodobenzoates; D003973:Diatrizoate; D007483:Iothalamic Acid; D007451:Iodamide