Inhibition, by drugs, of galactosamine induced hepatitis in the rat.
Four compounds, prednisolone, sodium phenobarbitone, azathioprine and orotic acid, were tested for their ability to inhibit galactosamine induced hepatitis in the rat. Prednisolone offered total protection at doses of 100 mg/kg and above; sodium phenobarbitone and orotic acid modified the response to galactosamine and azathioprine was without effect.
D000410:Alanine Transaminase / Q000097:blood; D000818:Animals; D001219:Aspartate Aminotransferases / Q000097:blood; D001379:Azathioprine / Q000627:therapeutic use*; D056486:Chemical and Drug Induced Liver Injury / Q000188:drug therapy* / Q000201:enzymology / Q000209:etiology; D004305:Dose-Response Relationship, Drug; D005688:Galactosamine; D008099:Liver / Q000473:pathology; D008297:Male; D009963:Orotic Acid / Q000627:therapeutic use*; D010634:Phenobarbital / Q000627:therapeutic use*; D011239:Prednisolone / Q000627:therapeutic use*; D051381:Rats
D009963:Orotic Acid; D005688:Galactosamine; D011239:Prednisolone; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase; D001379:Azathioprine; D010634:Phenobarbital