title: Effect of acute hypoxia on blood serotonin in human beings and rats.
abstract: The object of this study was to see if the blood level of 5-hydroxytryptamine (5-HT) increased under acute hypoxic stress in human beings and rats. Soldiers who had been stationed at high altititudes 2-7 months prior to study were selected. 17 had suffered from pulmonary oedema and the remaining eight, who had not developed the condition, acted as controls. The technique of YUWILER [18] with suitable modifications was used for estimation of 5-HT. No significant change in 5-HT levels was observed either in subjects or controls. Rats exposed to simulated high altitude for 6 h also did not show any significant change in blood 5-HT levels.
mesh_terms: D000531:Altitude; D000818:Animals; D006801:Humans; D006976:Hypertension, Pulmonary / Q000209:etiology; D000860:Hypoxia / Q000097:blood* / Q000150:complications; D011654:Pulmonary Edema / Q000097:blood; D051381:Rats; D012701:Serotonin / Q000097:blood*
chemical_list: D012701:Serotonin