[Functional state of the adrenal cortex in experimental animals administered leyorin and its sodium salt perorally].
The effect of oral levorin and its sodium salt on the function of the adrenal cortex was studied experimentally on albino rats. The functional activity of the adrenal cortex was tested by the content of corticosterone in the peripheral blood determined fluorometrically. The results showed that levorin in a dose of 300 000 Unit/kg and its sodium salt in doses of 300 000 and 1 200 000 Units/kg used orally induced at definite periods of their administration a decrease in the corticosterone blood levels. At the same time a decrease in the weight coefficients of the thymus and prostate was observed.
D000284:Administration, Oral; D000302:Adrenal Cortex / Q000187:drug effects*; D000311:Adrenal Glands / Q000187:drug effects*; D000818:Animals; D000935:Antifungal Agents / Q000008:administration & dosage* / Q000494:pharmacology; D001835:Body Weight / Q000187:drug effects; D003345:Corticosterone / Q000097:blood; D003864:Depression, Chemical; D004305:Dose-Response Relationship, Drug; D008297:Male; D009929:Organ Size / Q000187:drug effects; D011090:Polyenes / Q000008:administration & dosage / Q000494:pharmacology; D051381:Rats; D013997:Time Factors
D000935:Antifungal Agents; D011090:Polyenes; D003345:Corticosterone
Funktsional'noe sostoianie kory nadpochechnikov éksperimental'nykh zhivotnykh pri peroral'nom vvedenii levorina i ego natrievoĭ soli