title: Synthetic and naturally occurring hydrazines as possible cancer causative agents.
abstract: The various synthetic substituted hydrazines, which cause tumors in animals, are briefly enumerated. To date, 19 of them have proved to be tumorigenic in animals. A number of these chemicals are found today in the environment, in industry, in agriculture, and in medicine, and the human population is exposed to a certain degree to some of them. Hydrazine also occurs in nature in tobacco and tobacco smoke. The three other naturally occurring hydrazine compounds are N-methyl-N-formylhydrazine, which occurs in the wild edible mushroom, Gyromitra esculenta, and beta-N-[gamma-L(+)-glutamyl]-4-hydroxymethylphenylhydrazine and 4-hydroxymethylphenylhydrazine, which are found in the commonly eaten cultivated mushroom, Agaricus bisporus. Tumorigenesis studies with the naturally occurring hydrazines are in progress.
mesh_terms: D001487:Basidiomycota; D002273:Carcinogens; D004127:Dimethylhydrazines; D004781:Environmental Exposure; D006834:Hydrazines; D007538:Isoniazid; D009002:Monomethylhydrazine; D010659:Phenylhydrazines; D010947:Plants, Toxic; D012907:Smoking; D014026:Nicotiana
chemical_list: D002273:Carcinogens; D004127:Dimethylhydrazines; D006834:Hydrazines; D010659:Phenylhydrazines; D009002:Monomethylhydrazine; D007538:Isoniazid