Experimental immune retinitis: induction by isolated photoreceptors.
An antigen prepared from the outer limbs of the photoreceptors failed to produce retinal lesions within 3 months by systemic immunisation alone in the rabbit. Intra-vitreal injection of the antigen in a pre-immunised rabbit resulted in an Arthus type response. Repeated systemic immunisation for over 1 year after an intravitreal injection produced retinal degeneration in the uninjected eyes of two rabbits. Anti-visual cell antibodies were not shown to be cytotoxic to organ cultures of retina. Possible reasons are discussed in relation to in vitro studies of thyroid, kidney and spinal cord.
D000818:Animals; D000906:Antibodies; D000941:Antigens; D001323:Autoantibodies; D002417:Cattle; D003601:Cytotoxicity Tests, Immunologic; D006168:Guinea Pigs; D007114:Immunization; D010101:Oxygen Consumption; D010786:Photoreceptor Cells / Q000276:immunology*; D011817:Rabbits; D051381:Rats; D012160:Retina / Q000276:immunology / Q000378:metabolism; D012173:Retinitis / Q000276:immunology* / Q000473:pathology; D013997:Time Factors
D000906:Antibodies; D000941:Antigens; D001323:Autoantibodies