title: Effect of dietary protein and tryptophan and the turnover of rat liver ornithine aminotransferase.
abstract: Under controlled conditions of diet, age, and animal management we confirmed our earlier studies that the fractional turnover rate constant of rat liver ornithine aminotransferase (L-ornithine:2-oxoacid aminotransferase, EC 2.6.1.13) was about 0.4 day-1 when estimated by tracer technique. However, when estimated by the kinetics of enzyme activity perturbation during dietary induction or return to normal levels, a value of about 0.7 day-1 was obtained. This discrepancy may now be attributed in part to a transistory change in the fractional rate constant during enzyme adaption.
mesh_terms: D000818:Animals; D002364:Caseins / Q000494:pharmacology; D004044:Dietary Proteins; D007700:Kinetics; D008099:Liver / Q000187:drug effects / Q000201:enzymology*; D008297:Male; D008930:Mitochondria, Liver / Q000187:drug effects / Q000378:metabolism; D009953:Ornithine-Oxo-Acid Transaminase / Q000378:metabolism*; D051381:Rats; D013997:Time Factors; D000637:Transaminases / Q000378:metabolism*; D014364:Tryptophan / Q000494:pharmacology*
chemical_list: D002364:Caseins; D004044:Dietary Proteins; D014364:Tryptophan; D000637:Transaminases; D009953:Ornithine-Oxo-Acid Transaminase