title: Myocardial contractility during peridural anesthesia.
abstract: Cardiac contractility was studied in 4 groups of patients using, as parameter, the I/(PEP)2 index proposed by Reitan. 15 patients received 10 mg diazepam i.v. as sedation. The patients in group I were given lumbar peridural anesthesia with 20 ml prilocaine 2%. There was no significant change in the index. The patients in group II were given lumbar peridural anesthesia with 20 ml prilocaine and adrenalin 1/200,000. For 20 to 30 minutes there was a marked rise in the index. The patients in group III received the same lumbar peridural anesthesia as group II, but with a subsequent subcutaneous injection of 50 mg ephedrine HCl. At first the index rose rapidly; this rise was followed by a more rapid return to the initial value. Finally, the patients in group IV, who were under stabilized NLA narcosis, received 2 mg/kg prilocaine intravenously. There was no change in the index before and after the injection.
mesh_terms: D000368:Aged; D000767:Anesthesia, Epidural; D002302:Cardiac Output; D003975:Diazepam / Q000494:pharmacology; D004809:Ephedrine / Q000494:pharmacology; D004837:Epinephrine / Q000494:pharmacology; D006801:Humans; D008297:Male; D008875:Middle Aged; D009200:Myocardial Contraction / Q000187:drug effects*; D011229:Preanesthetic Medication; D011318:Prilocaine / Q000494:pharmacology; D013997:Time Factors
chemical_list: D011318:Prilocaine; D004809:Ephedrine; D003975:Diazepam; D004837:Epinephrine