title: Carcinoma of the urinary bladder. Influence of dose and volume irradiated on survival.
abstract: Two groups with comparable bladder carcinoma were selected from 249 patients treated with telecobalt therapy from 1955 through 1971. Group I received a mean isocentric dose of 6,060 rads in six weeks to an average volume of about 1,050 cm3 within the 90% isodose lines; Group II received a mean isocentric dose of 6,542 rads in six and one-half weeks to a volume of approximately 1,700 cm3. Overall five-year survival rates were 12.6% (+/- 5.4) in Group I and 25.5% (+/- 4) in Group II, with improvement being most marked in patients with advanced stages of disease. Results show that when the dose was increased and a larger volume of pelvic tissue was irradiated, the five-year survival rate improved.
mesh_terms: D000230:Adenocarcinoma / Q000401:mortality / Q000473:pathology / Q000532:radiotherapy; D000328:Adult; D000368:Aged; D002277:Carcinoma / Q000401:mortality / Q000473:pathology / Q000532:radiotherapy*; D002294:Carcinoma, Squamous Cell / Q000401:mortality / Q000473:pathology / Q000532:radiotherapy; D002295:Carcinoma, Transitional Cell / Q000401:mortality / Q000473:pathology / Q000532:radiotherapy; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011879:Radiotherapy Dosage; D001749:Urinary Bladder Neoplasms / Q000401:mortality / Q000473:pathology / Q000532:radiotherapy*