Four familial translocations ascertained through spontaneous abortions.
In a study of 514 spontaneous abortions, 194 were found to have a chromosome anomaly. Of these, 4 (2.1%) were unbalanced translocations. Three of the translocations were Robertsonian (13q14q) and one was reciprocal. Each translocation was ascertained independently and each was associated with a balanced rearrangement in a carrier parent.
D000022:Abortion, Spontaneous / Q000235:genetics*; D002869:Chromosome Aberrations; D002901:Chromosomes, Human, 13-15; D002902:Chromosomes, Human, 16-18; D002906:Chromosomes, Human, 6-12 and X; D005260:Female; D005333:Fetus / Q000166:cytology; D006801:Humans; D008297:Male; D010375:Pedigree; D011247:Pregnancy; D014178:Translocation, Genetic