[Effect of gamma-irradiation on some biological and physico-chemical properties of polyene antibiotics].
Deep effect of gamma-rays on polyenic antibiotics was studied. It was shown that gamma-radiation induced radiation-chemical oxidation of the substances. The chromatographic analysis showed that the levorin degradation products were identical to the polyenic products of the antibiotic oxidative destruction. As for mycoheptin and amphotericin B, destruction of their molecules to non-polyenic products was observed. It was found that toxicity of the levorin aromatic heptaen did not practically change after gamma-irradiation in high doses. The toxicity of mycoheptin and amphotericin B, non-aromatic heptaens increased after exposure to high doses of gamma-rays.
D000666:Amphotericin B / Q000528:radiation effects / Q000633:toxicity; D000818:Animals; D000900:Anti-Bacterial Agents / Q000528:radiation effects*; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D004307:Dose-Response Relationship, Radiation; D005720:Gamma Rays; D007928:Lethal Dose 50; D051379:Mice; D011090:Polyenes / Q000528:radiation effects*; D011830:Radiation Effects; D013056:Spectrophotometry, Ultraviolet
D000900:Anti-Bacterial Agents; D011090:Polyenes; D000666:Amphotericin B
Vliianie gamma-oblucheniia na nekotorye biologicheskie i fiziko-khimicheskie svoĭstva polienovykh antibiotikov