[The effect of cystamine on the outcome of dominant lethal mutations and reciprocal translocations in sex cells of mice subjected to gamma-irradiation in different doses].
Protective effect of cystamine (150 mg/kg) against genetic damages induced by gamma-irradiation in germ cells of male mice of CBA strain (at doses of 100, 300, 600 r) was studied. The application of cystamine decreased the frequency of dominant lethal mutations induced by radiation in sperms, spermatids and spermatocytes. The degree of the protective effect of cystamine depended on a radiation dose. The protective effect of cystamine was the highest at the radiation dose of 300 r. It was negligible at the radiation dose of 100 r and was completely absent at the dose of 600 r. Cystamine did not affect the rate of induced reciprocal translocations in the spermatogonia at all the radiation doses used.
D000818:Animals; D003538:Cystamine / Q000627:therapeutic use*; D004307:Dose-Response Relationship, Radiation; D005720:Gamma Rays; D005799:Genes, Dominant; D005804:Genes, Lethal; D008297:Male; D051379:Mice; D009154:Mutation / Q000187:drug effects; D011831:Radiation Genetics; D011833:Radiation Injuries, Experimental / Q000517:prevention & control*; D013094:Spermatozoa / Q000528:radiation effects*; D014178:Translocation, Genetic / Q000187:drug effects
D003538:Cystamine
Vliianie tsistamina na vykhod dominantnykh letal'nykh mutatsii i retsiproknykh translokatsii v polovykh kletkakh mysheĭ, podvergshikhsia gamma-oblucheniiu v raznykh dozakh