title: The spirographic "kink". A sign of emphysema.
abstract: The significance of the "kink" occurring in the early portion of the forced expiratory spirogram of some patients with obstructed airflow was investigated in 153 patients with chronic obstructive pulmonary disease or asthma. The kink, which is presumably due to airway collapse, is facilitated by the presence of emphysema, which results in loss of elastic recoil, a positive pleural pressure, high bronchiolar resistance, and structural weakness in the walls of the major airways. A significant reduction of carbon-monoxide diffusing capacity was used as the indicator of the presence of significant anatomic emphysema. Eighty percent (39) of 49 patients with the spirographic kink had a low diffusing capacity, whereas only 16 of those without the kink had significantly impaired diffusion. Seventy percent (39) of the 56 patients who had emphysema by this criterion demonstrated a spirographic kink. This test is, therefore, offered as a simple, effective, and widely applicable screening procedure for detecting emphysema, with a low incidence of false-positive results.
mesh_terms: D001249:Asthma / Q000150:complications; D002248:Carbon Monoxide; D004646:Emphysema / Q000150:complications / Q000175:diagnosis*; D005189:False Positive Reactions; D005260:Female; D005540:Forced Expiratory Flow Rates; D006801:Humans; D008173:Lung Diseases, Obstructive / Q000150:complications; D008297:Male; D008403:Mass Screening / Q000379:methods; D011653:Pulmonary Diffusing Capacity; D012129:Respiratory Function Tests; D013147:Spirometry
chemical_list: D002248:Carbon Monoxide