Effect of non-ionic detergents on the absorption of oleic acid in the anaesthetised rat.
The effects of bile salts and of the non-ionic detergents Tween 80 and Pluronic F68 on the absorption and esterification of oleic acid (in presence of monoglyceride) by loops of rat intestine "in vivo" were studied. Absorption of oleic acid was highest from 10mM taurocholate, but was also substantial from the non-ionic detergents. Tween 80 acted synergistically with low concentrations of bile salts. Most of the absorbed fatty acid recovered in the intestinal wall was esterified, the proportion found as triglyceride being greater when a non-ionic detergent had been present. Under the conditions of these experiments a much smaller proportion of radio-active label left the intestine after absorption from 10mM taurocholate than from 2mM taurocholate or from the non-ionic detergents. The detergents Tween 80 and Pluronic F68 in low concentrations may improve absorption of fatty acids where this is impaired due to bile salt deficiency.
D000818:Animals; D001647:Bile Acids and Salts / Q000494:pharmacology; D003902:Detergents / Q000494:pharmacology*; D005260:Female; D007408:Intestinal Absorption / Q000187:drug effects*; D009829:Oleic Acids / Q000378:metabolism*; D011136:Polysorbates / Q000494:pharmacology; D051381:Rats
D001647:Bile Acids and Salts; D003902:Detergents; D009829:Oleic Acids; D011136:Polysorbates