[The effect of increased extracellular calcium concentration on the hypoxic and pharmacologic hyperemia of skeletal muscle].
The influence of an increased Ca concentration on reactive hyperemia, work induced vasodilation and pharmacologically induced dilation (adenosine, nifedipine, verapamil) was studied in the blood perfused gastrocnemius of dogs. Reactive hyperemia, work induced vasodilation and increased blood flow by administration of adenosine could not be influenced by increased extracellular Ca concentrations. A Ca antagonism was demonstrated for nifedipine and verapamil, especially with regard to a diminution of the drug eff.
D000241:Adenosine / Q000494:pharmacology; D000818:Animals; D002118:Calcium / Q000494:pharmacology*; D004285:Dogs; D006940:Hyperemia / Q000139:chemically induced / Q000503:physiopathology*; D000860:Hypoxia / Q000139:chemically induced / Q000503:physiopathology*; D009132:Muscles / Q000098:blood supply*; D009543:Nifedipine / Q000494:pharmacology; D012039:Regional Blood Flow / Q000187:drug effects; D013268:Stimulation, Chemical; D014700:Verapamil / Q000494:pharmacology
D014700:Verapamil; D009543:Nifedipine; D000241:Adenosine; D002118:Calcium
Der Einfluss erhöhter extrazellulärer Kalziumkonzentrationen auf die hypoxische und pharmakologische Mehrdurchblutung des Skelettmuskels