Relationship between renal function and elimination kinetics of pindolol in man.
In view of a previous report suggesting an increased metabolism of the beta-blocking agent pindolol with decreasing renal function in man, the relationship between renal function and the elimination kinetics of pindolol has been re-examined. There is a statistically significant positive correlation between the renal clearances of pindolol and creatinine but there is no correlation between the non-renal clearance of pindolol and the renal clearance of creatinine. Thus, there is no evidence of an increased metabolism (non-renal clearance) of pindolol with decreasing renal function.
D003404:Creatinine / Q000652:urine; D006801:Humans; D007668:Kidney / Q000378:metabolism / Q000502:physiology*; D008657:Metabolic Clearance Rate; D010869:Pindolol / Q000378:metabolism* / Q000652:urine
D003404:Creatinine; D010869:Pindolol