title: Collaborative study of a column chromatographic method for bendroflumethizide and cyclothiazide.
abstract: Bendroflumethiazide and cyclothiazide are eluted from a sodium carbonate column with chloroform-acetic acid (98+2) and are measured directly by ultraviolet spectrophotometry. The method was collaboratively studied by 8 analysts. The average per cent recovery and standard deviations for simulated mixes of bendroflumethiazide and cyclothiazide were 99.61+/-0.78 and 99.3+/-1.97. The method has been adopted as official first action for the determination of bendroflumethiazide.
mesh_terms: D001539:Bendroflumethiazide / Q000032:analysis*; D001581:Benzothiadiazines; D002845:Chromatography / Q000379:methods*; D004232:Diuretics; D004338:Drug Combinations; D009636:Norbornanes / Q000032:analysis; D049993:Sodium Chloride Symporter Inhibitors / Q000032:analysis*; D012997:Solvents; D013056:Spectrophotometry, Ultraviolet; D013607:Tablets / Q000032:analysis
chemical_list: D001581:Benzothiadiazines; D004232:Diuretics; D004338:Drug Combinations; D009636:Norbornanes; D049993:Sodium Chloride Symporter Inhibitors; D012997:Solvents; D013607:Tablets; D001539:Bendroflumethiazide; C004639:cyclothiazide