[Xylitol metabolism in human erythrocytes].
1. Washed human erythrocytes metabolize 1,14 muMol xylitol in 120 min under the following experimental conditions: pH 7.4 and 37 degrees C. 2. The levels of 2,3-diphosphoglycerate and ATP decrease during the incubation with xylitol. This decrease is not a specific effect of xylitol, but depends on the amount of C-atoms taken up. This could be shown in control experiments with fructose and glucose as substrates given separated or in combination with xylitol. The highest uptake of C-atoms has been observed with glucose plus xylitol as substrate. 3. 99% of the metabolized xylitol was recovered in the products lactate, Co2 and D-xylulose. 4. There was no measurable oxalate production from xylitol.
D000255:Adenosine Triphosphate / Q000378:metabolism; D002245:Carbon Dioxide / Q000378:metabolism; D004163:Diphosphoglyceric Acids / Q000378:metabolism; D004912:Erythrocytes / Q000378:metabolism*; D006801:Humans; D007773:Lactates / Q000378:metabolism; D013997:Time Factors; D014993:Xylitol / Q000097:blood* / Q000378:metabolism; D014996:Xylulose / Q000378:metabolism
D004163:Diphosphoglyceric Acids; D007773:Lactates; D002245:Carbon Dioxide; D014996:Xylulose; D000255:Adenosine Triphosphate; D014993:Xylitol
Xylitstoffwechsel im menschlichen Erythrozyten