Rubella 1974 and its aftermath, congenital rubella syndrome.
An epidemic of rubella reached its peak in the Atlantic provinces in 1974, subsiding in early 1975. With the exception of Quebec the remainder of Canada showed a reverse trend, with a large increase in the numbers of cases reported in the first 41/2 months of 1975. The Halifax virus laboratory reported 106 serologically proven cases of rubella in 1974, 44 of them in pregnant women. In the aftermath of the epidemic many infants were born with the congenital rubella syndrome (CRS). A study carried out from Sept. 1, 1974 through Apr. 30, 1975 showed an 80% correlation between clinical diagnosis and the presence of rubella-specific IgM antibodies in 35 of these infants. Of the 23 infants in whom the diagnosis of CRS was made by laboratory or clinical findings or both, laboratory criteria were met in 20 (87.0%), clinical criteria in 19 (82.6%) and both laboratory and clinical criteria in 16 (69.6%).
D000914:Antibodies, Viral / Q000032:analysis; D002170:Canada; D019411:Clinical Laboratory Techniques / Q000592:standards; D000013:Congenital Abnormalities / Q000175:diagnosis; D004196:Disease Outbreaks; D006385:Hemagglutination Inhibition Tests; D006801:Humans; D007075:Immunoglobulin M / Q000032:analysis; D007223:Infant; D007231:Infant, Newborn; D010808:Physical Examination; D012409:Rubella / Q000151:congenital* / Q000276:immunology / Q000382:microbiology; D012412:Rubella virus / Q000302:isolation & purification
D000914:Antibodies, Viral; D007075:Immunoglobulin M