[Action of clostridial spores on transplantation tumors in alloxan-diabetic rats (author's transl)].
With the intention to improve the up to now unsatisfying effectiveness of tumour treatment by clostridial spores, the influence of Alloxan-induced hyperlglycemia on clostridial therapy in two transplantable tumours of the rat are examined. Contrary to the isolated clostridial application the combined treatment causes a significant improvement of therapeutic effects (tumour-necrosis and -liquefaction, decreased growth-rate-quotient). The examination of antibody titers against clostridial rods shows in animals with Alloxan-diabetes a more early and more powerful increase in comparison with the isolated clostridial application. The importance of these results for therapy and serological diagnosis of malignant tumours is discussed.
D000818:Animals; D000907:Antibodies, Bacterial; D000912:Antibodies, Neoplasm; D002279:Carcinoma 256, Walker / Q000276:immunology / Q000628:therapy*; D003013:Clostridium / Q000276:immunology*; D003520:Cyclophosphamide / Q000627:therapeutic use; D003921:Diabetes Mellitus, Experimental; D007165:Immunosuppression Therapy; D008297:Male; D009368:Neoplasm Transplantation; D051381:Rats; D012513:Sarcoma, Experimental / Q000276:immunology / Q000628:therapy*; D013171:Spores, Bacterial
D000907:Antibodies, Bacterial; D000912:Antibodies, Neoplasm; D003520:Cyclophosphamide
Zur Wirkung von Clostridien-Sporen auf Transplantationstumoren der alloxan-diabetischen Ratte