The carcinogenic effect of dimethylnitrosamine on the Chinese hamster (Cricetulus griseus).
Three groups of Chinese hamsters (20 males, 20 females/group) received weekly subcutaneous injections for life of dimethylnitrosamine (DMN) at dose levels 0.20, 0.10 and 0.05 of the LD50. Eighty-two to 100% of the animals developed tumors of vascular origin. The neoplasms were primarily hepatic hemangioendotheliomas and their incidence was unrelated to dose or sex. Although animals in the low dose group received a total dose which was one-third that of the highest dose group, their survival times were only slightly longer.
D000818:Animals; D002273:Carcinogens; D006224:Cricetinae; D004128:Dimethylnitrosamine / Q000008:administration & dosage / Q000633:toxicity*; D004305:Dose-Response Relationship, Drug; D005260:Female; D006390:Hemangioendothelioma / Q000139:chemically induced*; D007279:Injections, Subcutaneous; D008113:Liver Neoplasms / Q000139:chemically induced*; D008297:Male; D008647:Mesocricetus; D051379:Mice; D009374:Neoplasms, Experimental / Q000139:chemically induced; D009602:Nitrosamines / Q000633:toxicity*; D013045:Species Specificity
D002273:Carcinogens; D009602:Nitrosamines; D004128:Dimethylnitrosamine