HbS in nine Romanian families.
Thirty-two cases of HbS hemoglobinosis diagnosed in nine families of Romania are reported. Of these 26 were HbS trait carriers and 6 were double heterozygous presenting an association of HbS and beta-thalassemia. In the latter, one of the patients was carrier of HbS and the other had minor thalassemia with increased values of HbA2. It is stressed that the patients had a rather mild clinical form of hemolytic anemia, in spite of the very high concentration of HbS in the erythrocytes.
D000328:Adult; D000755:Anemia, Sickle Cell / Q000453:epidemiology / Q000235:genetics*; D002675:Child, Preschool; D005260:Female; D006801:Humans; D008297:Male; D010375:Pedigree; D012383:Romania; D012805:Sickle Cell Trait / Q000453:epidemiology