Activation of tryptophan pyrrolase by benzylhydrazine.
The mechanism responsible for the activation of tryptophan pyrrolase (TP) by benzylhydrazine (BZH) was investigated. The increase in holo/apo ratio of rat TP activity after addition of BZH in concentration of 1 x 10(-4)M, which is a major metabolite of isocarboxazid (ISOC), was higher than those in mice and guinea pigs. In addition, treatment with ISOC to rats (50 mg/kg i.p.) resulted in a significant increase in TP activity. These results suggested that the BZH-induced elevation of TP is at least in part due to a stimulation of conjugation step of TP activity.
D000818:Animals; D003600:Cytosol / Q000201:enzymology; D004789:Enzyme Activation / Q000187:drug effects; D006168:Guinea Pigs; D006834:Hydrazines / Q000494:pharmacology*; D007700:Kinetics; D008099:Liver / Q000187:drug effects / Q000201:enzymology*; D051379:Mice; D051381:Rats; D013045:Species Specificity; D014366:Tryptophan Oxygenase / Q000378:metabolism*
D006834:Hydrazines; D014366:Tryptophan Oxygenase