Extraction of biologically active erythropoietin from kidneys of carbon monoxide intoxicated mice.
Carbon monoxide injected subcutaneously in mice produces a profound intoxication during a six hour-period. From 2 to 4 hr after the start of carbon monoxide (CO)-hypoxemia large amounts of erythropoietin (ESF) are released in the plasma. Renal extracts obtained at the same time showed higher specific activity than that found in the plasma extracts. No activity was recovered from liver and spleen extracts. Removal of the kidney abolishes totally the production of ESF.
D000818:Animals; D002249:Carbon Monoxide Poisoning / Q000097:blood*; D004921:Erythropoietin / Q000378:metabolism*; D005260:Female; D007668:Kidney / Q000378:metabolism*; D051379:Mice; D013154:Spleen / Q000378:metabolism; D013997:Time Factors
D004921:Erythropoietin