title: Effects of antisera to S-100 protein and to synaptic membrane fraction on maze performance and EEG.
abstract: Topical cortical injection into rats of antiserum to the synaptic membrane fraction caused recurrent spiking activity as observed in the EEG; neither antiserum to S-100 protein nor antiserum to myelin caused any such abnormality. These same rats, when observed on a maze learning task (Lashley III) responded differently to the different antisera. Rats receiving injections of antiserum to the synaptic membrane fraction or antiserum to S-100 protein were inhibited in their performance, while rats injected with antiserum to myelin behaved like uninjected animals.
mesh_terms: D000818:Animals; D002540:Cerebral Cortex / Q000502:physiology*; D004569:Electroencephalography; D007106:Immune Sera; D007858:Learning / Q000502:physiology*; D008297:Male; D009186:Myelin Sheath / Q000276:immunology; D009419:Nerve Tissue Proteins / Q000276:immunology*; D051381:Rats; D009418:S100 Proteins / Q000276:immunology*; D013570:Synaptic Membranes / Q000276:immunology*
chemical_list: D007106:Immune Sera; D009419:Nerve Tissue Proteins; D009418:S100 Proteins