[Effect of naphthenic acids on the permeability of ascitic tumor cells to potassium ions].
Ascite cells were treated with naphthenic acid preparation, containing a mixture of naphthenic acids with average molecular weight equal to 240, and with a fraction of this preparation differing in the boiling temperature. A 5-10(-7)M and higher concentrations of the preparation and its fraction brought about an increased permeability in ascite cells for K-ions. The effectiveness of naphthenic acids is associated with their hydrophobic properties, which was characterized in the present communication by the value of hydrophilic-lipophilic balance calculated according to the Davies formula.
D000818:Animals; D002286:Carcinoma, Ehrlich Tumor / Q000378:metabolism*; D002463:Cell Membrane Permeability / Q000187:drug effects*; D003509:Cyclohexanecarboxylic Acids / Q000494:pharmacology*; D051379:Mice; D009368:Neoplasm Transplantation; D011188:Potassium / Q000378:metabolism*; D013501:Surface-Active Agents / Q000494:pharmacology*
D003509:Cyclohexanecarboxylic Acids; D013501:Surface-Active Agents; D011188:Potassium
Vliianie naftenovykh kislot na pronitsaemost' astsitnykh opukholevykh kletok dlia ionov kaliia