Carcinogen and smoke induced early alterations in the Syrian golden hamster respiratory epithelium as revealed by electron microscopy.
Syrian golden hamsters were treated once weekly with 0.63 mg B(a)P administered intratrracheally. Another group of hamsters was exposed once daily for one year to the smoke of research cigarettes by means of a smoking machine (Type Hamburg II). Trachea, lobar and segmental bronchi of the animals were examined electron microscopically. The smoke induced epithelial alterations resembled, in many aspects, those caused by a ten week B(a)P treatment.
D000818:Animals; D001980:Bronchi; D002273:Carcinogens / Q000494:pharmacology*; D006224:Cricetinae; D004848:Epithelium / Q000187:drug effects / Q000648:ultrastructure; D008854:Microscopy, Electron; D012137:Respiratory System / Q000187:drug effects*; D012906:Smoke; D014132:Trachea / Q000648:ultrastructure
D002273:Carcinogens; D012906:Smoke