title: [Optimization of the nutrient medium makeup for the biosynthesis of carminomycin using mathematical methods of experimental design].
abstract: The nutrient medium for biosynthesis of carminomycin by Actinomadura carminata, strain 4281 was optimized with the methods of mathematical planning of the experiment. The starting variant of the medium, production of carminomycin on which was assumed equal to 100 per cent was enriched during the experiments carried out according to the patterns of the orthogonal latin squares. The production levels of carminomycin on the above medium was more than 3 times higher than those on the starting medium.
mesh_terms: D000192:Actinomycetales / Q000378:metabolism; D000903:Antibiotics, Antineoplastic / Q000096:biosynthesis*; D002360:Carubicin / Q000096:biosynthesis*; D003470:Culture Media / Q000378:metabolism*; D004305:Dose-Response Relationship, Drug; D008433:Mathematics; D012107:Research Design
chemical_list: D000903:Antibiotics, Antineoplastic; D003470:Culture Media; D002360:Carubicin
vernacular_title: Optimizatsiia sostava pitatel'noĭ sredy dlia biosinteza karminomitsina s pomoshch'iu matematicheskikh metodov planirovaniia éksperimenta