Separation of complement-dependent and lymphocyte-dependent cytotoxic activity in human sera.
Two human sera having both complement-dependent and lymphocyte-dependent antibody activities (CDA, LDA) were applied to isoelectrofocusing columns. Maximum LDA activity for both sera was found focused at a higher pH than maximum CDA activity. The studies suggest that LDA molecules may exist without having complement-dependent activity.
D000906:Antibodies / Q000032:analysis; D003165:Complement System Proteins / Q000378:metabolism*; D003601:Cytotoxicity Tests, Immunologic; D006801:Humans; D007074:Immunoglobulin G / Q000032:analysis; D007525:Isoelectric Focusing; D008214:Lymphocytes / Q000276:immunology*
D000906:Antibodies; D007074:Immunoglobulin G; D003165:Complement System Proteins