Effect of cold stress on rapeseed oil fed rats.
No mortality was observed in 6 week old male Sprague-Dawley rats subjected to cold at 4 C for 3 weeks and fed either a control diet (Chow) or a semisynthetic diet containing 20% by wt rapeseed oil high in erucic acid (23.6%). All rats fed the Chow diet and 17 of 20 rats fed the rapeseed oil-containing diet survived 4 weeks in the same environment. Three rats on the latter diet died of self-mutilation. Marked myocardial lipidosis as well as a large acumulation of 20:1 and 22:1 was observed in the hearts of rats fed the rapeseed oil-containing diet. Five of 20 rats on the Chow diet and 2 of 20 rats on the rapeseed oil-containing diet had focal necrotic areas in the myocardium.
D000818:Animals; D001835:Body Weight; D003080:Cold Temperature; D004041:Dietary Fats; D005227:Fatty Acids / Q000378:metabolism; D050356:Lipid Metabolism; D008297:Male; D009206:Myocardium / Q000378:metabolism / Q000473:pathology; D009336:Necrosis; D009821:Oils / Q000494:pharmacology*; D010944:Plants; D051381:Rats; D013312:Stress, Physiological / Q000378:metabolism* / Q000401:mortality / Q000473:pathology
D004041:Dietary Fats; D005227:Fatty Acids; D009821:Oils