The long-chain acyl-CoA hydrolase activity in the heart of rat fed on rape-seed oil.
1. Fat feeding (soybean oil or erucic acid-rich rape-seed oil) enhance after 2 to 7 days the palmitoyl-CoA hydrolase activity in the heart of weanling rats in a degree dependent on the content of fat in the diet. 2. The rise in enzyme activity between the 7th and 14th day of feeding, observed only in rats fed on rape-seed oil, coincides with the decrease in lipid infiltration in the heart. 3. The obtained results suggest that palmitoyl-CoA hydrolase may control in the heart the amount of acyl-CoA thioesters in the cell, thus decreasing the lipidosis induced by eurcic acid.
D000818:Animals; D004041:Dietary Fats; D004305:Dose-Response Relationship, Drug; D006321:Heart / Q000187:drug effects; D008297:Male; D009206:Myocardium / Q000201:enzymology*; D009821:Oils / Q000494:pharmacology*; D010944:Plants; D051381:Rats; D013025:Glycine max; D013045:Species Specificity; D013869:Thiolester Hydrolases / Q000378:metabolism*; D013997:Time Factors
D004041:Dietary Fats; D009821:Oils; D013869:Thiolester Hydrolases