[The stability of amphetaminil. Syntheses with amphetaminil (author's transl)].
Amphetaminil (AN 1), chemically an alpha-phenyl-alpha-[(1-methyl-2-phenyl)-ethylamino]-acetonitrile (1), i.e. a derivative of alpha-aminonitrile, is stable under experimental conditions of preparation, reacting to neither acid nor alkali. It is a uniform substance, and it can be led to derivatives, such as derivatives of acryl (8-13) which are splittable into the corresponding alpha-amino-acid (7). It yields the corresponding hydantoin (4) and it is split up by oxidation with hydrogenperoxide in alkaline medium into an amide (14). These changes and the occurrence of amphetaminil--both under soft and energetic conditions of preparation--make it most improbable to split up easily amphetamine in the organism. Therefore, the existence of amphetamine under chromatographical conditions proves trace elements which are conditioned by use of disproportionately high quantities of solvents. These small quantities are practically irrelevant in case of preparation. They cannot be registered by preparations.
D000607:Aminoacetonitrile / Q000031:analogs & derivatives; D000661:Amphetamine / Q000032:analysis; D055598:Chemical Phenomena; D002621:Chemistry; D003500:Cyclization; D004355:Drug Stability; D006827:Hydantoins / Q000138:chemical synthesis; D006868:Hydrolysis; D010627:Phenethylamines; D011437:Propylamines
D006827:Hydantoins; D010627:Phenethylamines; D011437:Propylamines; D000607:Aminoacetonitrile; D000661:Amphetamine
Die Stabilität von Amphetaminil. Synthesen mit Amphetaminil