title: Blood endotoxin inactivation after trauma and endotoxicosis.
abstract: In contrast to the inability to demonstrate endotoxin detoxifying activity in either control rat blood, blood cells, plasma, or serum, the induction of mild endotoxemia or trauma resulted in a prompt and marked detoxifying activity in blood plasma or serum, but not in the cellular elements. The functional significance of the blood anti-endotoxin system was demonstrated by a capability for passive transfer and by its loss during severe traumatic shock. A role for the RES in elaboration of the blood anti-endotoxin system is postulated.
mesh_terms: D000818:Animals; D000992:Antitoxins; D004731:Endotoxins; D007116:Immunization, Passive; D008297:Male; D051381:Rats; D012772:Shock, Septic / Q000276:immunology*; D012774:Shock, Traumatic / Q000276:immunology*; D013997:Time Factors
chemical_list: D000992:Antitoxins; D004731:Endotoxins