Correlation between coronary venous inosine concentration and myocardial wall thickening during regional ischemia.
Correlations between local mechanical and metabolic events were studied during partial decrease in flow in the left anterior descending coronary artery in the open-chest pig. During ischemia, systolic ventricular wall thickening decreased. Concomitantly, the concentration of inosine, hypoxanthine, lactate, and potassium in the regional anterior coronary vein increased, whereas the concentration of these compounds in the femoral artery did not change. A negative correlation was observed between the venous inosine concentration and the decreased myocardial wall thickening during ischemia. This study indicates that the local venous inosine concentration is a sensitive indicator of regional myocardial ischemia in the pig.
D000244:Adenosine Diphosphate / Q000378:metabolism; D000249:Adenosine Monophosphate / Q000378:metabolism; D000255:Adenosine Triphosphate / Q000378:metabolism; D000818:Animals; D002462:Cell Membrane / Q000378:metabolism; D003327:Coronary Disease / Q000503:physiopathology*; D003331:Coronary Vessels / Q000378:metabolism*; D004195:Disease Models, Animal; D006321:Heart / Q000503:physiopathology*; D007288:Inosine / Q000378:metabolism*; D009206:Myocardium / Q000378:metabolism*; D013552:Swine
D000249:Adenosine Monophosphate; D007288:Inosine; D000244:Adenosine Diphosphate; D000255:Adenosine Triphosphate