Generalized lymphadenopathy and nephrotic syndrome as a manifestation of mephenytoin (mesantoin) toxicity.
This report describes a patient who developed marked generalized adenopathy and nephrotic syndrome while receiving mephenytoin (mesantoin) for a seizure disorder. Renal biopsy showed a diffuse proliferative glomerulonephritis. Lymph node histopathology revealed replacement of parenchyma with lymphocytes, eosinophils, and reticuloendothelial cells. A hypersensitivity reaction is postulated as the etiology of both these processes.
D000293:Adolescent; D004487:Edema / Q000139:chemically induced; D004827:Epilepsy / Q000188:drug therapy; D006801:Humans; D006827:Hydantoins / Q000009:adverse effects*; D008206:Lymphatic Diseases / Q000139:chemically induced*; D008297:Male; D008617:Mephenytoin / Q000009:adverse effects* / Q000627:therapeutic use; D009404:Nephrotic Syndrome / Q000139:chemically induced*
D006827:Hydantoins; D008617:Mephenytoin