title: Variation of urate excretion with urine flow in normal man.
abstract: In normal persons, a decrease in urine flow following the injection of small amounts of vasopressin was accompanied by a significant decrease in the clearance and excretion of urate. When vasopressin and a small natriuretic dose of mannitol were administered together, urine flow and urate excretion again decreased. The recovery of urine flow to control values was accompanied by a similar recovery of urate excretion. Because a natriuretic dose of mannitol did not reverse the antiuricosuric effect of the flow decline, it is postulated that the flow effect probably reflects changes in a component of urate efflux distal to the loop of Henle.
mesh_terms: D000328:Adult; D004231:Diuresis; D006801:Humans; D007444:Inulin / Q000097:blood / Q000652:urine; D007668:Kidney / Q000187:drug effects / Q000502:physiology*; D008297:Male; D008353:Mannitol / Q000494:pharmacology; D009994:Osmolar Concentration; D012964:Sodium / Q000652:urine; D014527:Uric Acid / Q000097:blood / Q000652:urine*; D014554:Urination / Q000187:drug effects; D014667:Vasopressins / Q000494:pharmacology
chemical_list: D014667:Vasopressins; D014527:Uric Acid; D008353:Mannitol; D007444:Inulin; D012964:Sodium