Relation between structure and cholinergic activity. II. Synthesis and muscarinic activity of some sulfur analogs of 2-methyl-4-trimethylammoniomethyl-1,3-dioxolane-iodide.
The synthesis of 2-methyl-5-trimethylammoniomethyl-1,3-oxathiolane and some homologs are described. The stereochemical aspects are discussed on the basis of the NMR-spectra. The muscarinic activity of the oxathiolane is compared with the activities of the corresponding dioxolane and dithiolane.
D000109:Acetylcholine / Q000494:pharmacology; D000818:Animals; D001001:Anura; D004148:Dioxolanes / Q000138:chemical synthesis* / Q000494:pharmacology; D004149:Dioxoles / Q000138:chemical synthesis*; D004305:Dose-Response Relationship, Drug; D066298:In Vitro Techniques; D007583:Jejunum / Q000187:drug effects; D009682:Magnetic Resonance Spectroscopy; D009119:Muscle Contraction / Q000187:drug effects; D009130:Muscle, Smooth / Q000187:drug effects; D010277:Parasympathomimetics / Q000138:chemical synthesis*; D051381:Rats; D013329:Structure-Activity Relationship; D013455:Sulfur
D004148:Dioxolanes; D004149:Dioxoles; D010277:Parasympathomimetics; D013455:Sulfur; D000109:Acetylcholine