title: Acute hemorrhagic conjunctivitis in Tunisia. Report of viral isolations.
abstract: Acute hemorrhagic conjunctivitis (AHC), a new disease entity first reported in 1969, has since become pandemic throughout the world. In Tunisia during an epidemic in 1972 to 1973 we studied 25 cases of AHC, which were characterized by explosive onset of lid edema, chemosis, conjunctival hemorrhages, follicular hypertrophy, and epithelial keratitis. Clinical signs peaked in 48 hours and cleared without sequelae in five to seven days. Paired acute- and convalescent-phase sera from six of the patients showed a rising titer of neutralizing antibody to the prototype strain of AHC virus (J6 70/71), which was isolated in Japan. Two viral isolates from Tunisian patients were also antigenically related to the Japanese strain, indicating that a single etiologic agent (a new member of the picornavirus group) is probably responsible for the current pandemic of AHC.
mesh_terms: D000914:Antibodies, Viral / Q000032:analysis; D003231:Conjunctivitis / Q000453:epidemiology / Q000382:microbiology* / Q000635:transmission; D004196:Disease Outbreaks / Q000453:epidemiology; D006470:Hemorrhage / Q000382:microbiology*; D006801:Humans; D009500:Neutralization Tests; D010849:Picornaviridae / Q000276:immunology / Q000302:isolation & purification*; D014416:Tunisia
chemical_list: D000914:Antibodies, Viral