Microbiological hydroxylation of norethisterone.
Hydroxylation of norethisterone by a large number of fungi has been investigated. 1alpha-Hydroxy-, 6beta-hydroxy-, 10beta-hydroxy-, 10beta,11beta-dihydroxy-15alpha-and 15beta-hydroxy-derivatives were formed from norethisterone. The microbiological dehydrogenation of 10beta-hydroxy-norethisterone resulting in 10beta,17beta-dihydroxy-17-ethynyl-1,4-estradien-3-one was also observed. The structure of transformation products was established by chemical and spectroscopical methods.
D055598:Chemical Phenomena; D002621:Chemistry; D003271:Contraceptive Agents, Female; D005658:Fungi / Q000378:metabolism*; D006900:Hydroxylation; D009640:Norethindrone / Q000378:metabolism*; D013045:Species Specificity
D003271:Contraceptive Agents, Female; D009640:Norethindrone