[Change in rabbit blood lymphocyte count after repeated extracorporeal irradiation with cesium 137. Comparison of heparin and acenocoumarol effects].
During repetitive extracorporeal irradiation, heparin treatment is responsible for a very high lymphocytic peak which does not last more than two days. This peak is not observed after using acenocoumarol as anticoagulant. That is why the degree of lymphocyte depletion after RECIB is to be interpreted in function of the anticoagulant used. This peak is temporary. No matter the anticoagulant used, lymphopenia is obtained after 15 days. The level of lymphocytic depletion is independent of the initial lymphocytosis.
D000074:Acenocoumarol / Q000494:pharmacology*; D000818:Animals; D002588:Cesium Radioisotopes; D006098:Granulocytes / Q000187:drug effects / Q000528:radiation effects; D006493:Heparin / Q000494:pharmacology*; D007958:Leukocyte Count; D008214:Lymphocytes / Q000187:drug effects / Q000528:radiation effects*; D008297:Male; D011817:Rabbits; D011830:Radiation Effects
D002588:Cesium Radioisotopes; D006493:Heparin; D000074:Acenocoumarol
Modification du taux des lymphocytes sanguins chez le lapin aprés irradiation extra-corporelle répétée (IECSR) au césium 137. Action comparée de l'héparine et de l'acénocoumarol