title: Sodium ion transport in isolated intestinal epithelial cells. II. Comparison of the effect of actively transported sugars on sodium ion efflux in cells isolated from jejunum and ileum.
abstract: Na+ transport studies in intestinal epithelial cells indicate that enterocytes from different regions of the small intestine differ in their response to actively transported sugars. 1. Compared with sugar-free medium total Na+ efflux rate constants from isolated rat jejunal cells were significantly increased when medium contained actively transported sugars, glucose and galactose, but not when medium contained fructose. 2 In contrast total Na+ efflux rate constants from isolated rat ileal cells did not respond to actively transported sugars, glucose and galactose. 3. Similar results for the effect of actively transported sugars on Na+ ellux were obtained for isolated rabbit jejunal and ileal epithelial cells. 4. Passive Na+ efflux rate constants for isolated jejunal and ileal enterocytes are not significantly different, indicating similiar permeability characteristics.
mesh_terms: D000818:Animals; D001693:Biological Transport, Active; D004847:Epithelial Cells; D004848:Epithelium / Q000187:drug effects / Q000378:metabolism; D005632:Fructose / Q000494:pharmacology; D005690:Galactose / Q000494:pharmacology; D005947:Glucose / Q000494:pharmacology; D006601:Hexoses / Q000494:pharmacology*; D007082:Ileum / Q000187:drug effects / Q000378:metabolism*; D066298:In Vitro Techniques; D007583:Jejunum / Q000187:drug effects / Q000378:metabolism*; D008353:Mannitol / Q000494:pharmacology; D011817:Rabbits; D051381:Rats; D012964:Sodium / Q000378:metabolism*
chemical_list: D006601:Hexoses; D005632:Fructose; D008353:Mannitol; D012964:Sodium; D005947:Glucose; D005690:Galactose