Ketamine-pancuronium-narcotic technic for cardiovascular surgery in infants--a comparative study.
Ketamine, pancuronium, and alphaprodine were used as the primary anesthetic agents in 71 infants requiring cardiovascular operations during a recent 1-year period. This group of patients was compared with a similar group anesthetized 3 years before with d-tubocurarine, halothane, and/or N20-O2. Stability of the circulatory system was well maintained with ketamine-pancuronium-narcotic (KPN) during the induction period. However, once surgical dissection of the heart and great vessels began, hypotension/bradycardia, ventricular fibrillation, and 48-hour mortality were similar for the two groups. Therefore, using these criteria for analysis, the KPN technic, in spite of claims for its minimal adverse effect on the cardiovascular system, did not prove superior to the halothane-N2O-O2-curare technic.
D000522:Alphaprodine / Q000008:administration & dosage / Q000009:adverse effects*; D000768:Anesthesia, General; D001919:Bradycardia / Q000139:chemically induced; D006348:Cardiac Surgical Procedures; D006221:Halothane / Q000009:adverse effects; D006330:Heart Defects, Congenital / Q000601:surgery; D006801:Humans; D007022:Hypotension / Q000139:chemically induced; D007223:Infant; D007649:Ketamine / Q000008:administration & dosage / Q000009:adverse effects*; D009609:Nitrous Oxide / Q000009:adverse effects; D010197:Pancuronium / Q000008:administration & dosage / Q000009:adverse effects*; D014403:Tubocurarine / Q000009:adverse effects; D014693:Ventricular Fibrillation / Q000139:chemically induced
D000522:Alphaprodine; D007649:Ketamine; D010197:Pancuronium; D009609:Nitrous Oxide; D006221:Halothane; D014403:Tubocurarine