IgG catabolism in anephric patients.
The catabolism of purified human 125I labelled IgG has been studied in patients with chronic renal failure, both nephrectomised and non-nephrectomised, on intermittent haemodialysis. In all patients the T 1/2 of IgG was the same as in normal controls, and using chromatographic separation on Sephadex G200, there was no evidence of alteration of molecular size as a result of dialysis. The results do not support the notion that the kidney is an important site of IgG catabolism in humans.
D000328:Adult; D005260:Female; D006801:Humans; D007074:Immunoglobulin G / Q000378:metabolism*; D007457:Iodine Radioisotopes; D007676:Kidney Failure, Chronic / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D009392:Nephrectomy; D006435:Renal Dialysis
D007074:Immunoglobulin G; D007457:Iodine Radioisotopes