[Influence of coronary-effective substances on the concentration of nonesterified fatty acids in the serum of patients with angina pectoris].
In a study of patients with angina pectoris the influence of coronary-effective medicaments on the concentration of non-esterified fatty acids was investigated. Supplementary establishments were carried out experimentally on pigs. Compared with normal persons patients with angina pectoris had a significantly higher level of non-esterified fatty acids. In an oral dose of 150 mg a day propranolol decreased the non-esterified fatty acids to normal values. Dipyridamol decreased the concentration of non-esterified fatty acids in the serum in an average dose of 450 mg a day also significantly. The combination of propranolol and dipyridamol did not evoke a particular additive effect on the decrease of non-esterified fatty acids. In a dosage of 300 mg a day orally trapymin had no clear influence on the non-esterified fatty acids. D,L-oxyfedrin (64 mg orally a day) increased the concentration of the non-esterified fatty acids in the serum. The decrease of the level of non-esterified fatty acids seems important for the prophylaxis of the infarction. The antilipolytic effect is a desirable therapeutic mechanism among others in the coronary therapy.
D000787:Angina Pectoris / Q000097:blood* / Q000188:drug therapy; D000818:Animals; D004176:Dipyridamole / Q000008:administration & dosage; D004338:Drug Combinations; D005230:Fatty Acids, Nonesterified / Q000097:blood*; D006801:Humans; D010099:Oxyfedrine / Q000008:administration & dosage; D011412:Propanolamines / Q000008:administration & dosage*; D011433:Propranolol / Q000008:administration & dosage; D013552:Swine; D013997:Time Factors; D014192:Trapidil / Q000008:administration & dosage; D014665:Vasodilator Agents / Q000008:administration & dosage*
D004338:Drug Combinations; D005230:Fatty Acids, Nonesterified; D011412:Propanolamines; D014665:Vasodilator Agents; D004176:Dipyridamole; D011433:Propranolol; D010099:Oxyfedrine; D014192:Trapidil
Der Einfluss koronarwirksamer Substanzen auf die Konzentration der unveresterten Fettsäuren im Serum bei Patienten mit Angina pectoris