Unilateral "Page kidney" hypertension in man. Studies of the renin-angiotensin-aldosterone system before and after nephrectomy.
Hypertension developed in a 17-year-old boy one year after a flank injury. Intravenous pyelography showed a slightly smaller kidney on the injured side. Renal arteriography demonstrated unilateral decreased vascular filling. Renal vein ratios suggested an ischemic kidney, as did split-function studies. Nephrectomy cured the hypertension. Detailed studies before and after nephrectomy suggested that hyperactivity of the renin-angiotensin-aldosterone system may participate in the pathophysiology of this unusual cause of hypertension in man.
D000293:Adolescent; D000450:Aldosterone / Q000097:blood*; D000804:Angiotensin II / Q000097:blood*; D001706:Biopsy; D006801:Humans; D006977:Hypertension, Renal / Q000097:blood / Q000209:etiology* / Q000601:surgery; D007511:Ischemia / Q000209:etiology; D007668:Kidney / Q000098:blood supply / Q000293:injuries* / Q000473:pathology; D008297:Male; D009392:Nephrectomy; D012083:Renin / Q000097:blood*
D000804:Angiotensin II; D000450:Aldosterone; D012083:Renin