[Variation of the thyrotropin-releasing-hormone (TRH) stimulated thyrotropin (TSH) response in comparison with the tyhroid-gland-suppression test and the triiodothyronine (T3) and thyroxine (T4) blood levels in the so-called euthyroid endocrine ophthalmopathy].
21 patients with active signs of euthyroid Graves' disease were given 400 mug thyrotropin-releasing hormone (TRH) i.v. All subjects with unresponsiveness to TRH had a nonsuppressible thyroidal 131I-uptake. On the basis of serum total T3 14 patients were hyperthyroid, 2 more had an elevated value of free T3. 4 patients with normal total T3 and nonsuppressible 131I-uptake were unresponsive to TRH, in 2 of them the free T3 fraction was elevated, however. 4 subjects with nonsuppressible 131I-uptake had a TRH stimulated TSH response. 2 of these subjects had hyperthyroid values of free and total T3 in serum and responded to TRH with an exaggerate TSH increment. The variations of TRH responsiveness may demonstrate a different threshold of the pituitary and the peripheral T3 receptors.
D006111:Graves Disease / Q000097:blood*; D006801:Humans; D006980:Hyperthyroidism / Q000097:blood; D007457:Iodine Radioisotopes / Q000378:metabolism; D013268:Stimulation, Chemical; D013961:Thyroid Gland / Q000378:metabolism; D013972:Thyrotropin / Q000008:administration & dosage* / Q000378:metabolism; D014284:Triiodothyronine / Q000097:blood*
D007457:Iodine Radioisotopes; D014284:Triiodothyronine; D013972:Thyrotropin
Variationen der Thyrotropin-Releasing-Hormone (TRH) stimulierten Thyreotropin (TSH)-Antwort im Vergleich zum Schilddrüsensuppressionstest und den Trijodthyronin (T3)-und Thyroxin (T4)-Serumspiegeln bei sogenannter euthyreoter endokriner Ophthalmopathie