[Characteristics of the reaction of the renal tissue adenylic system to the beta-adrenoblockader, trasicor (oxprenolol), in early postnatal ontogeny].
Trasicor (oxprenolol) was introduced intraperitoneally to mongrel albino rats of 4 age groups (7, 14, 30 days old and adults) in single effective and resistance doses, following which the ATP, ADP, AMP and NP content in the renal tissue homogenates was determined. At early stages of postnatal ontogenesis the animals are shown to be less sensitive to the drug than in the case of adult rats. Possible increases in the dosage of trasicor in the pediatric practice are deemed permissible.
D000227:Adenine Nucleotides / Q000378:metabolism; D000241:Adenosine / Q000378:metabolism*; D000244:Adenosine Diphosphate / Q000378:metabolism; D000249:Adenosine Monophosphate / Q000378:metabolism; D000255:Adenosine Triphosphate / Q000378:metabolism; D000367:Age Factors; D000818:Animals; D004305:Dose-Response Relationship, Drug; D004351:Drug Resistance; D004361:Drug Tolerance; D004734:Energy Metabolism / Q000187:drug effects; D005260:Female; D006706:Homeostasis / Q000187:drug effects; D007668:Kidney / Q000187:drug effects* / Q000378:metabolism; D008297:Male; D010096:Oxprenolol / Q000494:pharmacology*; D051381:Rats
D000227:Adenine Nucleotides; D000249:Adenosine Monophosphate; D010096:Oxprenolol; D000244:Adenosine Diphosphate; D000255:Adenosine Triphosphate; D000241:Adenosine
Osobennosti reaktsii adenilovoĭ sistemy pochechnoĭ tkani na beta-adrenoblokator trazikor (oksprenolol) v rannem postnatal'nom ontogeneze