title: Some side-effects of alpha-methyldopa.
abstract: Three different regimens of drug treatment for hypertension were compared with regard to the development of undesirable side-effects in a group of 53 patients attending a hypertension clinic. The combination of alpha-methyldopa and chlorthalidone produced the highest incidence of side-effects. Weakness and impotence were most frequently encountered. In contrast, the combination of chlorthalidone, hydralazine and propranolol, and chlorthalidone alone, produced fewer side-effects. It is recommended that alpha-methyldopa should not be a first choice in the treatment of hypertension.
mesh_terms: D000328:Adult; D000368:Aged; D002752:Chlorthalidone / Q000009:adverse effects; D004359:Drug Therapy, Combination; D007172:Erectile Dysfunction / Q000139:chemically induced; D006801:Humans; D006830:Hydralazine / Q000009:adverse effects; D006973:Hypertension / Q000188:drug therapy; D008297:Male; D008750:Methyldopa / Q000009:adverse effects*; D008875:Middle Aged; D011433:Propranolol / Q000009:adverse effects
chemical_list: D006830:Hydralazine; D008750:Methyldopa; D011433:Propranolol; D002752:Chlorthalidone