The inhibitor effect of probencid and structural analogues on organic anions and chloride permeabilities in ox erythrocytes.
Probenecid inhibits anion movements (organic anions and chloride) in ox erythrocytes. The I50 is 4. 10(-5) M. Structural analogues such as carinamide, p-carboxybenzene sulfonamide and p-carboxy N,N-diethyl benzene sulfonamide, which are drugs of the sulfonamide class, were also found to inhibit anion transport. These results reinforce the previously discussed view based on structural considerations, that sulfonamides act on the red cell membrane as competitors of anion transport. It is possible that probenecid and carinamide act in a similar way in the kidney.
D000818:Animals; D001639:Bicarbonates / Q000097:blood; D001693:Biological Transport, Active; D002417:Cattle; D002712:Chlorides / Q000097:blood*; D004912:Erythrocytes / Q000187:drug effects / Q000378:metabolism*; D066298:In Vitro Techniques; D010070:Oxalates / Q000097:blood*; D011339:Probenecid / Q000031:analogs & derivatives / Q000494:pharmacology*; D011773:Pyruvates / Q000097:blood*; D013329:Structure-Activity Relationship; D013449:Sulfonamides / Q000494:pharmacology
D001639:Bicarbonates; D002712:Chlorides; D010070:Oxalates; D011773:Pyruvates; D013449:Sulfonamides; D011339:Probenecid