Effects of different drugs on the urinary excretion of nifurpipone (NP) and of nitrofurantoin (NTF) in the rat.
A study was made on possible interferences of several drugs on the urinary excretion of nifurpipone and of nitrofurantoin orally administered to rats. Phenobarbital, a microsomial enzyme inducer, SKF 525 A, a microsomial enzyme inhibitor, probenecid, an inhibitor of the tubular acid secretory system, quanine, an inhibitor of the tubular alkaline secretory system, and hydrochlorothiazide, a diuretic, were studied. None of these treatments altered in an important way the urinary excretion of nifurpipone or of nitrofurantoin.
D000284:Administration, Oral; D000818:Animals; D004305:Dose-Response Relationship, Drug; D004347:Drug Interactions; D006852:Hydrochlorothiazide / Q000494:pharmacology; D008297:Male; D009581:Nitrofurans / Q000008:administration & dosage / Q000652:urine*; D009582:Nitrofurantoin / Q000008:administration & dosage / Q000652:urine*; D010634:Phenobarbital / Q000494:pharmacology; D011335:Proadifen / Q000494:pharmacology; D011339:Probenecid / Q000494:pharmacology; D011803:Quinine / Q000494:pharmacology; D051381:Rats; D013997:Time Factors
D009581:Nitrofurans; D006852:Hydrochlorothiazide; D009582:Nitrofurantoin; D011335:Proadifen; D011803:Quinine; D011339:Probenecid; D010634:Phenobarbital