The effect of blood flow upon the activity of gallamine triethiodide.
The onset, depth and recovery from paralysis produced by gallamine triethiodide were studied using the tibialis anterior muscle/sciatic nerve preparation in mongrel dogs, during changes in blood flow to this muscle. A roller pump was used to effect the blood flow changes via an aorto-femoral shunt. The onset and depth of paralysis were related directly to muscle blood flow. There was no correlation between the rate of recovery from paralysis and the blood flow to the muscle.
D000818:Animals; D001783:Blood Flow Velocity; D001831:Body Temperature; D002302:Cardiac Output; D005703:Gallamine Triethiodide / Q000009:adverse effects* / Q000097:blood; D009132:Muscles / Q000098:blood supply* / Q000187:drug effects; D010243:Paralysis / Q000139:chemically induced; D012039:Regional Blood Flow; D013997:Time Factors
D005703:Gallamine Triethiodide