[Changes in the mitotic regime of cultures of continuous human amniotic cells (line A1) subjected to the action of decamethoxin].
The effect of decamethoxin solutions on the cultures of the permanent line of the amniotic human cells (A1) was studied. In concentrations of 1000 and 50-500 gamma/ml decamethoxin induced fixation of the cell layer and destruction of cells A1 respectively. Higher dilutions of decamethoxin from 10 to 0.1 gamma/ml induced suppression of the mitotic activity and arrest of the cells in the telophase. Possible causes of the changes in the mitotic regimen are discussed. Therefore, decamethoxin slackened the cell dividing process in vitro and blocked passage of the cells from the telophase into period G1 of the interphase.
D000653:Amniotic Fluid / Q000166:cytology*; D002460:Cell Line; D002478:Cells, Cultured / Q000187:drug effects*; D003650:Decamethonium Compounds / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D006801:Humans; D008938:Mitosis / Q000187:drug effects*; D013997:Time Factors
D003650:Decamethonium Compounds
Izmeneniia mitoticheskogo rezhima kul'tur perevivaemykh amnioticheskikh kletok cheloveka (linii A1), podvergnutykh vozdeĭstviiu dekametoksina