[Effect of immunodepression on virus multiplication and interferon and antibody formation in animals].
Administration of high doses of imuran had no significant effect on the multiplication of influenza A/PR8 and Coxsackie A6 viruses. However, the serum levels of interferon and antibody were completely suppressed. Peripheral leukocytes of mice given imuran produced no interferon in vitro. These data suggest that the impairment of formation of the antiviral immunity factors resulting from the administration of high doses of immunosuppressants, such as used during the graft rejection crises, could serve as one of the main causes facilitating viral infections in the course of the transplantation therapy. The results could be of practical importance for the development of the optimal immunosuppression schedules during the organ transplantation.
D000818:Animals; D000917:Antibody Formation / Q000187:drug effects; D001379:Azathioprine; D004770:Enterovirus / Q000254:growth & development; D007165:Immunosuppression Therapy; D007166:Immunosuppressive Agents; D007372:Interferons / Q000096:biosynthesis*; D051379:Mice; D009522:Newcastle disease virus / Q000254:growth & development; D009975:Orthomyxoviridae / Q000254:growth & development; D014779:Virus Replication / Q000187:drug effects
D007166:Immunosuppressive Agents; D007372:Interferons; D001379:Azathioprine
Vliianie immunodepressii na razmnozhenie virusov, obrazovanie interferona i antitel u zhivotnykh