Changes in kidney and liver function after methoxyflurane (penthrane) anaesthesia.
Three groups of patients receiving methoxyflurane or halothane or pethidine after thiopentone suxamethonium induction were compared. Using multivariate Student t tests with simultaneous confidence intervals, significant differences in the test battery of uric acid, creatinine, blood urea nitrogen and sodium in the methoxyflurane series compared with the other series was found, indicating transient impaired kidney function. Likewise, there was a significant difference between the methoxyflurane and the other series in the s.g.p.t., s.g.o.t., alkaline phosphatase and bilirubin test battery, indicating impaired liver function. This was found after doses less than 16 ml which, so far, had been considered to be without any toxic effects.
D000328:Adult; D000410:Alanine Transaminase / Q000097:blood; D000469:Alkaline Phosphatase / Q000097:blood; D001219:Aspartate Aminotransferases / Q000097:blood; D001806:Blood Urea Nitrogen; D003404:Creatinine / Q000097:blood; D004305:Dose-Response Relationship, Drug; D005260:Female; D006221:Halothane / Q000494:pharmacology; D006801:Humans; D007668:Kidney / Q000187:drug effects*; D008099:Liver / Q000187:drug effects*; D008614:Meperidine / Q000494:pharmacology; D008733:Methoxyflurane / Q000009:adverse effects / Q000494:pharmacology*; D008875:Middle Aged; D012964:Sodium / Q000097:blood; D014527:Uric Acid / Q000097:blood
D014527:Uric Acid; D008733:Methoxyflurane; D008614:Meperidine; D012964:Sodium; D003404:Creatinine; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase; D000469:Alkaline Phosphatase; D006221:Halothane