[The action of insulin on ribonucleic acid metabolism (author's transl)].
The incorporation of 3H-uridine into liver ribosomes is reduced in alloxan-diabetic rats. This reduction affects mRNA as well as rRNA. Insulin-substitution therapy of diabetic animals restores to normal the incorporation rates of uridine into both mRNA and rRNA. There is a manifest connection between the known reduction of polyribosomes in diabetes mellitus and reduced synthesis of mRNA; moreover, a connection to the reduced production of rRNA seems also to be possible.
D000818:Animals; D003921:Diabetes Mellitus, Experimental / Q000378:metabolism; D066298:In Vitro Techniques; D007328:Insulin / Q000494:pharmacology*; D008099:Liver / Q000648:ultrastructure; D008297:Male; D012313:RNA / Q000378:metabolism*; D012333:RNA, Messenger / Q000378:metabolism; D012335:RNA, Ribosomal / Q000378:metabolism; D051381:Rats; D012270:Ribosomes / Q000187:drug effects* / Q000378:metabolism; D014529:Uridine / Q000378:metabolism
D007328:Insulin; D012333:RNA, Messenger; D012335:RNA, Ribosomal; D012313:RNA; D014529:Uridine
Zur Wirkung von Insulin auf den Ribonukleinsäure-Stoffwechsel