Morphological alterations induced in organ cultures of human fetal trachea and bronchi by diethylnitrosamine (DEN).
Human fetal respiratory tract was exposed to the action of N-nitrosodiethyl-amine (DEN), a potent carcinogen for other species, in a organ culture system. The dose of 15 mul/ml DEN elicited an intensive proliferative response of the respiratory epithelium while higher doses were toxic.
D001980:Bronchi / Q000166:cytology / Q000187:drug effects* / Q000196:embryology; D004052:Diethylnitrosamine / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D004847:Epithelial Cells; D006801:Humans; D009602:Nitrosamines / Q000494:pharmacology*; D009924:Organ Culture Techniques; D014132:Trachea / Q000166:cytology / Q000187:drug effects* / Q000196:embryology
D009602:Nitrosamines; D004052:Diethylnitrosamine