Effect of clonixin and aspirin on platelet aggregation in human volunteers.
The effect of clonixin and aspirin on platelet function was assessed in healthy volunteers. Both drugs inhibited secondary platelet aggregation and prolonged bleeding time, but the effect of clonixin was significantly less than that of aspirin. Hemorrhagic complications are less likely after clonixin than after aspirin.
D000244:Adenosine Diphosphate / Q000494:pharmacology; D000328:Adult; D001241:Aspirin / Q000008:administration & dosage / Q000494:pharmacology*; D001777:Blood Coagulation / Q000187:drug effects; D003002:Clonixin / Q000008:administration & dosage / Q000494:pharmacology*; D003094:Collagen / Q000494:pharmacology; D004837:Epinephrine / Q000494:pharmacology; D005260:Female; D006801:Humans; D008297:Male; D009539:Nicotinic Acids / Q000494:pharmacology*; D010974:Platelet Aggregation / Q000187:drug effects*; D013997:Time Factors
D009539:Nicotinic Acids; D000244:Adenosine Diphosphate; D003094:Collagen; D001241:Aspirin; D003002:Clonixin; D004837:Epinephrine