title: [Myelopathy and macrocytic anemia associated with a folate deficiency. Cure by folic acid].
abstract: The authors report a case of myelopathy associated with macrotic anemia. The prior inefficacy of treatment with B1, B6 and B12 vitamins, in spite of a normal Schilling test, suggested the possibility of folate deficiency, the concentration of which was found very low in the serum (1.5 mg/ml). The addition of folic acid to the vitamins already administered without success, was followed by rapid recovery of the anemia and a frank neurological improvement maintained after 10 months follow-up. The rare similar cases observed in the world literature are analysed here. The other neurological manifestations, due to folate deficiency, the etiological circumstances and the methods of diagnosis are recalled.
mesh_terms: D000328:Adult; D000368:Aged; D000437:Alcoholism / Q000150:complications; D000748:Anemia, Macrocytic / Q000209:etiology*; D005260:Female; D005492:Folic Acid / Q000627:therapeutic use; D005494:Folic Acid Deficiency / Q000150:complications* / Q000188:drug therapy / Q000209:etiology; D006801:Humans; D008297:Male; D008875:Middle Aged; D009461:Neurologic Manifestations; D013118:Spinal Cord Diseases / Q000188:drug therapy / Q000209:etiology*
chemical_list: D005492:Folic Acid
vernacular_title: Myélopathie et anémie macrocytaire associées à une carence en folates. Guérison par l'acide folique