Sympathetic influence on vascular smooth muscle contractility in renal hypertension in the rabbit.
The relation between sympathetic activity and vascular smooth muscle contractility in renal hypertension has been examined using, as a model, isolated central ear arteries from renal hypertensive and normotensive rabbits. The isolated arteries were perfused with Krebs solution and vasoconstrictor effects of noradrenaline and nerve stimulation were studied. It was found that in the absence of a functional sympathetic nervous system in arteries of renal hypertensive rabbits, the vascular smooth muscle showed marked decrease in response to noradrenaline. The results obtained indicate that trophic influence of the sympathetic nervous system on the vascular smooth muscle is essential for the integrity of the muscle and pertinent to renal hypertension in the rabbit.
D000818:Animals; D001158:Arteries / Q000503:physiopathology; D001794:Blood Pressure / Q000187:drug effects; D001808:Blood Vessels / Q000503:physiopathology*; D004423:Ear / Q000098:blood supply; D004558:Electric Stimulation; D005260:Female; D006977:Hypertension, Renal / Q000503:physiopathology*; D066298:In Vitro Techniques; D008297:Male; D009119:Muscle Contraction / Q000187:drug effects*; D009130:Muscle, Smooth / Q000503:physiopathology*; D009638:Norepinephrine / Q000494:pharmacology; D011817:Rabbits; D013564:Sympathetic Nervous System / Q000503:physiopathology*
D009638:Norepinephrine