title: [Changes in the corticosteroids and their alpha-ketol metabolites in the urine of hypertension patients treated with metopirons].
abstract: Results from the examinations of 20 hypertonics treated with methtopyron 4.5 g/24 h are presented. The values of S, THS, THF, THE and aldosterone in urine are determined, parallelly with plasma cortisol prior to and post hydroxilase blocker. An elevation of urinary THS and DOK was found, with depressed levels of aldosterone in urine and plasma cortisol. Those four indices permit a considerably precise assessment of involving and notinvolving of the different links of hypothalamo-hypophyseal-suprarenal system and the eventual location of the disturbance. Three of the hypertonics did not elevate THS and DOK in urine after methopyron, in spite of the inhibition of the urinary aldosterone and plasma cortisol. That was admitted to be a manifestation of a disturbance in the hypothalamo-hypophyseal functional reserves which might participate in the development and maintenance of the hypertensive disease.
mesh_terms: D000293:Adolescent; D000305:Adrenal Cortex Hormones / Q000652:urine*; D000328:Adult; D000450:Aldosterone / Q000652:urine; D002940:Circadian Rhythm; D003350:Cortodoxone / Q000031:analogs & derivatives / Q000652:urine; D003900:Desoxycorticosterone / Q000652:urine; D005260:Female; D006801:Humans; D006854:Hydrocortisone / Q000097:blood; D006973:Hypertension / Q000188:drug therapy / Q000652:urine*; D008297:Male; D008797:Metyrapone / Q000627:therapeutic use*; D008875:Middle Aged; D013761:Tetrahydrocortisone / Q000652:urine
chemical_list: D000305:Adrenal Cortex Hormones; D003900:Desoxycorticosterone; D000450:Aldosterone; D013761:Tetrahydrocortisone; D003350:Cortodoxone; D006854:Hydrocortisone; D008797:Metyrapone
vernacular_title: Promeni v kortikosteroidite i tekhnite alfa-ketolni metaboliti v urinata pri bolni ot khipertonichna bolest, tretirani s metopiron