[Interrelation of oxygen anion-radical generation and lipid peroxidation in liver microsomes].
Consumption of O2-radicals and malondialdehyde accumulation was studied in the liver microsomes (LM) of rat after phenobarbital and 3-methylcholantrene induction, and in the LM of rabbits; there was revealed a suppression of lipid peroxidation, but a sufficiently high level of O2-radical generation. It is supposed that the absence of any direct association between the lipid peroxidation activity and the O2-radical generation in the LM of rats induced with the mentioned agents and in the LM of rabbits depended on increase in the antioxidant level.
D000818:Animals; D003579:Cytochrome Reductases / Q000378:metabolism; D050356:Lipid Metabolism; D008748:Methylcholanthrene / Q000494:pharmacology; D008862:Microsomes, Liver / Q000187:drug effects / Q000201:enzymology / Q000378:metabolism*; D010545:Peroxides / Q000378:metabolism; D010634:Phenobarbital / Q000494:pharmacology; D011817:Rabbits; D051381:Rats
D010545:Peroxides; D008748:Methylcholanthrene; D003579:Cytochrome Reductases; D010634:Phenobarbital
Issledovanie vzaimosviazi generatsii anion-radikalov kisloroda s perekisnym okisleniem lipidov v mikrosomakh pecheni