A simple and sensitive gas chromatographic method for the determination of clonazepam in human plasma.
A simple gas chromatographic method for the determination of clonazepam in human plasma has been developed. After solvent extraction, the compound is measured by an electron capture detector on an OV-17 column. The electron-capture response is linear for 5-120 ng/ml of plasma. There is no interference from other commonly used anti-epileptic drugs or endogenous substrates. Preliminary data from routin monitoring of epileptic patients shows a 10-fold variation in their clonazepam plasma levels.
D001570:Benzodiazepinones / Q000097:blood*; D002849:Chromatography, Gas; D002998:Clonazepam / Q000008:administration & dosage / Q000097:blood* / Q000378:metabolism; D004827:Epilepsy / Q000188:drug therapy; D006801:Humans; D012997:Solvents; D013997:Time Factors
D001570:Benzodiazepinones; D012997:Solvents; D002998:Clonazepam