[Hemo and cross dialysis treatment in phalloidin intoxication in the waking rat].
In vitro 14C-Methyl-Phalloidin is found to be well dialysable; in vivo dialysis is less effective. In rats the application of 2 mg/kg Phalloidin i.v. led to death after 106 minutes on the average. Hemodialysis with electrolyte-glucose solution or with plasma protein solution immediately started after Phalloidin injection did not alter the survival time significantly. Only a group of rats which was cross dialysed immediately after intoxication showed a statistically insignificant prolongation of survival time of 16 minutes. The histomorphological findings of the liver were similar in all groups. We found a phalloidinic vacuolisation of the cytoplasm of the lobular periphery, hemorrhagic necrosis and also fatty changes in the periphery of the lobule with small fat droplets and pycnosis of nuclei. Specific Phalloidin effects, too, were found in the liver of both animals used in cross-dialysis, which proves that Phalloidin is dialysable by this method.
D000818:Animals; D001166:Arteriovenous Shunt, Surgical; D001786:Blood Glucose / Q000032:analysis; D001798:Blood Proteins / Q000627:therapeutic use; D005234:Fatty Liver / Q000139:chemically induced; D005260:Female; D005947:Glucose / Q000627:therapeutic use; D066298:In Vitro Techniques; D008099:Liver / Q000187:drug effects; D009336:Necrosis / Q000209:etiology; D009842:Oligopeptides / Q000506:poisoning*; D010590:Phalloidine / Q000506:poisoning*; D051381:Rats; D006435:Renal Dialysis
D001786:Blood Glucose; D001798:Blood Proteins; D009842:Oligopeptides; D010590:Phalloidine; D005947:Glucose
Hämo- und Cross-Dialysebehandlung der Phalloidin-Intoxikation an der wachen Ratte