[Pathogenesis of disorders of cardiac rhythm and conductivity in acute organophasphate insecticide poisoning].
A dynamic examination of ECG and K and Na level in plasma and erythrocyte was conducted in 73 patients during the acute period of poisoning with phosphorus-organic insecticides -- thiophos, chlorophos, carbophos. In 18.6% of the cases severe rhythm and conductivity disorders were revealed that caused cardiac arrest and death in 29 patients. Besides, a sharp increase in the electric systole on the ECG was noted in all the patients during the acute period of poisoning. A study of the electrolytes revealed hypokalemia, hypernatremia and an increased content of K and Na in the erythrocytes. The authors believe that the disturbances in the cardiac activity during acute poisonings with phosphorus-organic insecticides are due to the effect of the excessive acetylcholine upon the ion permeability towards increasing intracellular potassium.
D000208:Acute Disease; D000328:Adult; D001145:Arrhythmias, Cardiac / Q000097:blood / Q000201:enzymology / Q000209:etiology*; D002802:Cholinesterases / Q000097:blood; D005260:Female; D006801:Humans; D006955:Hypernatremia / Q000150:complications; D007008:Hypokalemia / Q000150:complications; D007306:Insecticides / Q000506:poisoning*; D008297:Male; D009943:Organophosphorus Compounds; D011188:Potassium / Q000097:blood; D012964:Sodium / Q000097:blood
D007306:Insecticides; D009943:Organophosphorus Compounds; D012964:Sodium; D002802:Cholinesterases; D011188:Potassium
O patogeneze narusheniia ritma i provodimosti serdtsa pri ostrykh otravleniiakh fosfororganicheskimi insektitsidami