title: Antimetabolites of pantothenic acid, ureido- and carbamoyl-derivatives.
abstract: Pantothenic acid analogs have been synthesized that contain alkyl and/or arylureido and carbamate functions in the beta-alanyl portion of the amide moiety of the vitamin. The analogs are inhibitory to growth of lactic acid bacteria at concentrations as low as 0.6 mug/ml, and the inhibitions are competitively reversed by supplements of pantothenic acid. The carbamate derivatives are more toxic to growth of Lactobacillus plantarum 8014 and Pediococcus cerevisiae 8042 than the ureido analogs, and chloro-substitutents on the aryl group significantly increase the toxicity of the analogs.
mesh_terms: D001419:Bacteria / Q000187:drug effects / Q000254:growth & development; D003470:Culture Media; D010205:Pantothenic Acid / Q000031:analogs & derivatives* / Q000378:metabolism / Q000494:pharmacology
chemical_list: D003470:Culture Media; D010205:Pantothenic Acid