[Adrenoreception characteristics of the neurons of the superior cervical and caudal mesenteric sympathetic ganglia of the cat].
Experiments were conducted on the supeior cervical and the caudal mesenteric sympathetic ganglia of a cat; it was shown that dophamine (DA), similarly to noradrenaline (NA) and adrenaline (A), depressed the cholinergic conduction. The activity of DA in the superior sympathetic ganglion was less than that of the NA and A 2- and 3-fold, respectively, and in the caudal mesenteric ganglia DA was 50 times more active than NA by the capacity to depress the cholinergic conduction. The effects of DA and NA in the superior cervical ganglia were eliminated by dyhydroergotamine, phentholamine and haloperidol, but not by tropaphen and chlorpormazine. In the caudal mesenteric ganglia the inhibitory effect of NA was decreased by phentholamine, dihydroergotamine and chlorpromazine, but not by haloperidol. On the contrary, haloperidol and chlorpromzine decreased the depressive effect of DA on the cholinergic conduction in the caudal mesenteric ganglion, whereas phentholamine, dihydroergotamine and deseryl proved to be ineffective. It is supposed that the manifestation of the dopaminergic mechanism of inhibition of cholinergic conduction in the caudal mesenteric sympathetic ganglion could underlie the dilatation of the mesenterial and renal vessels and its hypotensive action caused by DA.
D000200:Action Potentials / Q000187:drug effects; D000818:Animals; D002395:Catecholamines / Q000037:antagonists & inhibitors; D002415:Cats; D004298:Dopamine / Q000494:pharmacology; D004558:Electric Stimulation; D004837:Epinephrine / Q000494:pharmacology; D005725:Ganglia, Autonomic / Q000502:physiology*; D008643:Mesentery / Q000294:innervation*; D009333:Neck / Q000294:innervation*; D009474:Neurons / Q000502:physiology*; D009638:Norepinephrine / Q000494:pharmacology; D011941:Receptors, Adrenergic / Q000187:drug effects; D011950:Receptors, Cholinergic / Q000187:drug effects
D002395:Catecholamines; D011941:Receptors, Adrenergic; D011950:Receptors, Cholinergic; D004298:Dopamine; D009638:Norepinephrine; D004837:Epinephrine
Osobennosti adrenoretseptii neĭronov verkhnego sheĭnogo i kaudal'nogo bryzheechnogo simpaticheskikh gangliev koshki