[Morphological changes of the liver after chronic vinyl chloride intoxication (author's transl)].
The monomer vinyl chloride in its gaseous form is used as basic product for industrial synthesis of polyvinyl chloride; it does cause lesions of the liver depending on the dose and the time of exposure. Lesions found on histological examination are: 1. degenerative alterations of liver parenchyma; 2. focal adaptive changes in the cytoplasma of hepatocytes; 3. enlargement of liver cells and polymorphy of cell nuclei; 4. slowly progressive fibrotic and to a lesser degree cirrhotic changes of liver parenchyma, localized in part around the sinus, in part in the septal-periportal areas; 5. activation and proliferation of sinusoidal cells. Sarcoma of the liver due to a probable oncogenic effect of vinyl chloride could be diagnosed in three patients exposed to the toxic agent.
D000328:Adult; D002467:Cell Nucleus; D056486:Chemical and Drug Induced Liver Injury; D006394:Hemangiosarcoma / Q000139:chemically induced; D006801:Humans; D008099:Liver / Q000473:pathology*; D008113:Liver Neoplasms / Q000139:chemically induced; D008297:Male; D008875:Middle Aged; D009784:Occupational Diseases / Q000473:pathology*; D014752:Vinyl Chloride / Q000506:poisoning*; D014753:Vinyl Compounds / Q000506:poisoning*
D014753:Vinyl Compounds; D014752:Vinyl Chloride
Das morphologische Bild der Leberschädigung nach chronischer Vinylchlorid-Exposition