title: Effect of quality and quantity of dietary fat and dimethylhydrazine in colon carcinogenesis in rats.
abstract: The effect, quality, and quantity of dietary fat on colon tumor induction by DMH were studied in rats exposed to a given regimen for two generations prior to treatment with DMH. Animals fed a 20% corn oil or 20% lard and treated with DMH had a higher incidence of colonic tumors than did rats fed a 5% corn oil, 5% lard or Purina lab chow and treated similarly. The quality of fat had no major difference on the incidence of colonic tumors.
mesh_terms: D000230:Adenocarcinoma / Q000209:etiology*; D000818:Animals; D002277:Carcinoma / Q000209:etiology; D003110:Colonic Neoplasms / Q000139:chemically induced / Q000209:etiology*; D004041:Dietary Fats / Q000009:adverse effects*; D004127:Dimethylhydrazines; D004424:Ear Canal; D004428:Ear Neoplasms / Q000209:etiology; D005260:Female; D006834:Hydrazines; D007414:Intestinal Neoplasms / Q000209:etiology; D007680:Kidney Neoplasms / Q000209:etiology; D009374:Neoplasms, Experimental / Q000139:chemically induced / Q000209:etiology; D051381:Rats
chemical_list: D004041:Dietary Fats; D004127:Dimethylhydrazines; D006834:Hydrazines