[Familial hemolytic anemia and terminal renal failure (author's transl)].
We report about a patient with corpuscular hemolytic anemia and chronic glomerulonephritis in the state of terminal renal failure. The hematocrit decreased to 11% gradually with the progression of uremia. The hematological studies revealed the typical signs of hemolytic anemia. We found a splenic destruction of 51-Cr labelled red cells combined with an extremely short red cell life of 7 days. After splenectomy hematocrit improved to 32%. A complete normalisation could not be expected because of the chronic renal failure leading to anemia itself.
D000328:Adult; D000743:Anemia, Hemolytic / Q000150:complications / Q000235:genetics*; D003404:Creatinine / Q000097:blood; D004912:Erythrocytes; D005921:Glomerulonephritis / Q000150:complications; D006207:Half-Life; D006400:Hematocrit; D006454:Hemoglobins; D006801:Humans; D007676:Kidney Failure, Chronic / Q000150:complications* / Q000209:etiology; D007770:L-Lactate Dehydrogenase / Q000097:blood; D008297:Male; D006435:Renal Dialysis; D013156:Splenectomy
D006454:Hemoglobins; D003404:Creatinine; D007770:L-Lactate Dehydrogenase
Familiärer hämolytischer Ikterus und terminale Niereninsuffizienz