Depletion of cardiac norepinephrine during two forms of hemolytic anemia in the rat.
Knowledge of the status of cardiac norepinephrine (NE) during anemia could lead to a better understanding of the role the sympathetic nervous system plays in cardiac function during anemia. Rats were made anemic by treatment with phenylhydrazine (PHZ). After the rapid onset of anemia, 60% of the stored NE in the heart was lost within 48 hours after treatment. Associated with the loss of cardiac NE was an increase in the wet weight of the heart, which reached a value 40% above control 48 hours after treatment. PHZ itself probably does not directly mediate this depletion of NE, since the vas deferens, brain and spleen had a normal store of NE at 48 hours. This contention was supported when rats, treated with PHZ, were transfused with normal rat red blood cells. This transfusion resulted in PHZ-treated rats which were not anemic. The hearts of these rats were not depleted of NE, but the hearts of the nontransfused, PHZ-treated controls were. Anemia also was induced by treating rats with anti-rat red blood cell serum. The hearts of these rats also were depleted of NE. These experiments show that during two forms of anemia there is a loss of NE from the sympathetic neurons innervating the heart. The effect of this on regulation of cardiac function remains to be determined.
D000743:Anemia, Hemolytic / Q000139:chemically induced / Q000378:metabolism*; D000744:Anemia, Hemolytic, Autoimmune / Q000378:metabolism; D000818:Animals; D001921:Brain / Q000378:metabolism; D006321:Heart / Q000294:innervation; D008297:Male; D009206:Myocardium / Q000378:metabolism*; D009638:Norepinephrine / Q000378:metabolism*; D010659:Phenylhydrazines; D051381:Rats; D013154:Spleen / Q000378:metabolism; D013564:Sympathetic Nervous System / Q000502:physiology; D014649:Vas Deferens / Q000378:metabolism
D010659:Phenylhydrazines; D009638:Norepinephrine