title: [Enzymes of cultured human fibroblasts. IV. Enzyme activity in trisomy C strains].
abstract: The activity of five enzymes (AIP, AcP, GOT, LDH, MDH) was investigated in four cell strains derived from spontaneous abortuses  with C-trisomy (three cell strains with trisomy 7, one--with trisomy 9). Significant differences in the activity of three enzymes were revealed. In all the strains AIP activity was lower and GOT activity--higher than in diploid strains. Lowering of AcP level was found in three strains (two cell strains with trisomy 7, one--with trisomy 9). The data obtained are evaluated as a result of disturbed regulatory interrelations in an abnormal genome.
mesh_terms: D000135:Acid Phosphatase / Q000378:metabolism; D000469:Alkaline Phosphatase / Q000378:metabolism; D001219:Aspartate Aminotransferases / Q000378:metabolism; D002460:Cell Line; D002906:Chromosomes, Human, 6-12 and X; D005347:Fibroblasts / Q000201:enzymology*; D006801:Humans; D007770:L-Lactate Dehydrogenase / Q000378:metabolism; D008291:Malate Dehydrogenase / Q000378:metabolism; D014314:Trisomy
chemical_list: D007770:L-Lactate Dehydrogenase; D008291:Malate Dehydrogenase; D001219:Aspartate Aminotransferases; D000469:Alkaline Phosphatase; D000135:Acid Phosphatase
vernacular_title: Izuchenie fermentov kul'tiviruemykh fibroblastov cheloveka. Soobshchenie IV. Aktivnost' fermentov v C-trisomnykh shtammakh