[The influence of natural inhibitors of radical reactions on autooxidation of adrenaline].
In the presence of EDTA soluble antioxidants (1 muM reduced glutathion, 3 muM cystein, 1 muM ascorbic acid) inhibited the autoxidation of epinephrine at pH 10.2; as to alpha-tocopherol (40 muM) and the oxidative forms of these antioxidants - they were ineffective. The inhibitory effect of superoxide dismutase was much greater than that of the antioxidants testsd. The appearance of adrenochrome during the free radical autoxidation of epinephrine proceeded without any participation of the hydroxyl radical.
D000975:Antioxidants; D001205:Ascorbic Acid; D055598:Chemical Phenomena; D002621:Chemistry; D003545:Cysteine; D004837:Epinephrine; D005978:Glutathione; D007700:Kinetics; D010084:Oxidation-Reduction
D000975:Antioxidants; D005978:Glutathione; D003545:Cysteine; D001205:Ascorbic Acid; D004837:Epinephrine
Vliianie prirodnykh ingibitorov radikal'nykh reaktsiĭ na avtookislenie adrenalina