The effect of glucose-1 phosphate calcium on the epiphyseal cartilage of the rat.
Electron microscopic investigations were carried out on the proximal tibial epiphyseal cartilage of albino rats treated with 2 mg G-1-P-Ca daily for one and three weeks. The treatment--enhanced the secretory activity of the upper cells of the zone of maturing cartilage with a consequential enlargement of the Golgi region, depletion of secretory products, and an increase in the number of microtubuli. --In addition, the treatment increased the number of matrix vesicles in the extracellular space showing incipient calcification. This findings confirm the earlier light micriscopic observation of the calcification stimulating effect of G-1-P-Ca.
D000818:Animals; D002118:Calcium / Q000494:pharmacology*; D002356:Cartilage / Q000187:drug effects* / Q000473:pathology; D004838:Epiphyses / Q000473:pathology; D005958:Glucosephosphates / Q000494:pharmacology*; D006056:Golgi Apparatus / Q000473:pathology; D006984:Hypertrophy; D008870:Microtubules / Q000473:pathology; D051381:Rats; D013977:Tibia; D014617:Vacuoles / Q000473:pathology
D005958:Glucosephosphates; D002118:Calcium