[Model of bifunctional binding of rotenone and piericidin with mitochondrial NADH-dehydrogenase].
Based on authors' and literature data on the effect of inhibitors of mitochondrial NADH-dehydrogenase a scheme concerning bifunctional binding of specific inhibitors--piericidin A and rotenone with the enzyme is suggested. Analysis on the models, made in correspondence with the requirements of this scheme, permitted to propose conformations in which rotenoides interact with the enzyme.
D000900:Anti-Bacterial Agents / Q000494:pharmacology; D001665:Binding Sites; D008928:Mitochondria / Q000187:drug effects / Q000201:enzymology*; D008958:Models, Molecular; D009247:NADH, NADPH Oxidoreductases / Q000378:metabolism; D011485:Protein Binding; D012402:Rotenone / Q000494:pharmacology; D013329:Structure-Activity Relationship
D000900:Anti-Bacterial Agents; D012402:Rotenone; D009247:NADH, NADPH Oxidoreductases