[Postnatal growth inhibition in the rat retina after actinomycin D adminstration].
The effects of actinomycin D on the development of the rats retina were observed. At the day of birth the inner neurons and the inner cells of the bipolar layer are vulnerable. The pale degeneration of these neurons accompanied by a dilatation of the endoplasmatic reticulum and the dark degeneration accompanied by a pycnosis and a shrinkage of the cytoplasm persist during the first 11 days after birth. The same alterations are to be seen in bipolar cells on day 11 after birth. The transient disorganisation of the inner layers could effect the ramification because the stratum reticulare internum is smaller as in untreated animals.
D000818:Animals; D000831:Animals, Newborn; D003609:Dactinomycin / Q000494:pharmacology*; D004912:Erythrocytes; D008099:Liver / Q000187:drug effects; D051381:Rats; D012160:Retina / Q000187:drug effects* / Q000254:growth & development; D012162:Retinal Degeneration / Q000139:chemically induced*; D014617:Vacuoles
D003609:Dactinomycin
Wachstumshemmung der Rattenretina während der Postnatalziet nach Actinomycin D Gaben