A new model for human bioassay of topical corticosteroids.
The aiblity of topical corticosteroids to reduce the size of weals induced with histamine on human skin was used as a human bioassay model to assess their relative efficacy. Histamine was introduced by the pinprick method and various topical corticosteroids were assessed. It is a simple, easy and reliable procedure which can be used on both white and dark people. Even though it is a non-clinical assay, it possesses close similarity to processes involved in the development of clinical dermatoses.
D000287:Administration, Topical; D000293:Adolescent; D000328:Adult; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use*; D001507:Beclomethasone / Q000627:therapeutic use; D001624:Betamethasone Valerate / Q000627:therapeutic use; D004341:Drug Evaluation; D005443:Flumethasone / Q000627:therapeutic use; D005478:Flurandrenolone / Q000627:therapeutic use; D005938:Glucocorticoids / Q000627:therapeutic use*; D006801:Humans; D006854:Hydrocortisone; D006969:Hypersensitivity, Immediate / Q000188:drug therapy*; D011239:Prednisolone / Q000627:therapeutic use; D014222:Triamcinolone Acetonide / Q000627:therapeutic use
D000893:Anti-Inflammatory Agents; D005938:Glucocorticoids; D005478:Flurandrenolone; D001624:Betamethasone Valerate; D011239:Prednisolone; D014222:Triamcinolone Acetonide; D001507:Beclomethasone; D005443:Flumethasone; D006854:Hydrocortisone