Inflammatory effects of prostaglandin D2 in rat and human skin.
1 Intradermal injection of prostaglandin (PG) D1 and D2 in the human forearm produced a long-lasting dose-related erythema. When compared with prostaglandin E1 or E2 the order of potency for erythema production was PGE1 greater than PGE2 greater than PGD2 greater than PGD1. 2 In rat skin, prostaglandin D2 but not D1 caused an increase in vascular permeability as quantitated by the Evans blue method and the 125I-albumin extravasation technique. Prostaglandin E2 was 3-5 times more potent than prostaglandin D2. 3 Prostaglandin D2 (10 ng) potentiated the increase in vascular permeability in rat skin produced by histamine, but not that produced by bradykinin. 4 Prostaglandin D2 (10, 20 and 50 ng) did not elicit oedema or hyperalgesia in the rat paw oedema test, but potentiated carrageenan-induced oedema; hyperalgesia was potentiated by doses of 100 ng and above.
D000818:Animals; D001920:Bradykinin / Q000494:pharmacology; D002199:Capillary Permeability / Q000187:drug effects; D002351:Carrageenan; D006632:Histamine / Q000494:pharmacology; D006801:Humans; D007249:Inflammation / Q000139:chemically induced*; D007457:Iodine Radioisotopes; D008297:Male; D011453:Prostaglandins / Q000494:pharmacology*; D011458:Prostaglandins E / Q000378:metabolism; D051381:Rats; D012867:Skin / Q000187:drug effects* / Q000473:pathology; D013997:Time Factors
D007457:Iodine Radioisotopes; D011453:Prostaglandins; D011458:Prostaglandins E; D006632:Histamine; D002351:Carrageenan; D001920:Bradykinin