Effect of asparagine and arginine on the repair of isoprenaline-damaged myocardium of rat.
The effect of asparagine and arginine on the repair of isoprenaline-damaged myocardium was studied. In group I (treated with isoprenaline) the rats developed large foci of myocardial damage filled by connective tissue after 14 days. Similar changes were observed in group II (isoprenaline + asparagine). In group III of rats treated with isoprenaline and arginine the number of foci of injury and their size were smaller, and only a few small foci fibrosis were found after 14 days. Arginine seems to protect the rat myocardium from isoprenaline-induced damage. The repair by connective tissue is supplemented by compensatory hypertrophy of muscle fibers.
D000818:Animals; D001120:Arginine / Q000627:therapeutic use*; D001216:Asparagine / Q000627:therapeutic use*; D006321:Heart / Q000187:drug effects*; D006331:Heart Diseases / Q000188:drug therapy; D007545:Isoproterenol / Q000009:adverse effects*; D008297:Male; D009206:Myocardium / Q000378:metabolism / Q000473:pathology*; D009336:Necrosis; D051381:Rats
D001216:Asparagine; D001120:Arginine; D007545:Isoproterenol