[Effects of various agents and transmural electric stimulation on the motility of isolated bile duct of the dolphin (Stenella caeruleoalbus) (author's transl)].
The isolated bile duct preparations, which contain the duodenal circular muscle, and the proper bile duct muscle preparations in the dolphin (Stenella caeruleoalbus) were used and their longitudinal motilities were recorded by means of strain gauge transducer. 1. Raising the intraluminal pressure produced the augmentation of the motility of the bile duct preparation. 2. Acetylcholine and carbamylcholine caused the increase of the motility of the bile duct preparations. After atropinization the excitatory response was completely abolished. 3. Adrenaline caused the inhibitory response more predominantly than the excitatory one in the bile duct preparations, while in the proper bile duct muscle preparations it induced the excitatory response more predominantly than the inhibitory one. Phenylephrine produced mainly the excitatory effect in both preparations, while isoprenaline did chiefly the inhibitory one. These experimental results suggest that activation of alpha- and beta-adrenergic receptors in the bile duct muscle causes the excitatory and inhibitory responses, respectively. 4. Transmural electric stimulation induced both excitatory and inhibitory responses in the bile duct preparation. The former response was abolished after atropinization, while the latter one was not. It may be, therefore, suggested that the excitatory response was induced by stimulation of cholinergic neurons, while the inhibitory one was produced by that of the adrenergic fibers and non-adrenergic inhibitory neurons.
D000109:Acetylcholine / Q000494:pharmacology; D000818:Animals; D001285:Atropine / Q000494:pharmacology; D001652:Bile Ducts / Q000187:drug effects / Q000502:physiology*; D002217:Carbachol / Q000494:pharmacology; D002395:Catecholamines / Q000494:pharmacology; D004289:Dolphins / Q000502:physiology*; D004558:Electric Stimulation; D009538:Nicotine / Q000494:pharmacology; D010455:Peptides / Q000494:pharmacology
D002395:Catecholamines; D010455:Peptides; D009538:Nicotine; D001285:Atropine; D002217:Carbachol; D000109:Acetylcholine