Anticoagulant effect and plasma kinetics of fluorophenindione after a single dose in man.
After administration of a single  loading dose (80 mg p.o.) of fluorophenindione, the prothrombin level decreased to 37% in 24 h, and the effect lasted for 48 h. Accordingly, fluorophenindione can be classified as an anticoagulant with an ""intermediate'' effect. Its elimination half-life was 31 h, which is longer than that of phenindione, because of the greater stability of the fluorinated derivate.
D000284:Administration, Oral; D000328:Adult; D000925:Anticoagulants / Q000008:administration & dosage / Q000097:blood*; D004305:Dose-Response Relationship, Drug; D005260:Female; D006207:Half-Life; D006801:Humans; D007700:Kinetics; D008297:Male; D008875:Middle Aged; D008954:Models, Biological; D010630:Phenindione / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000097:blood; D011517:Prothrombin Time
D000925:Anticoagulants; D010630:Phenindione