Heparin effects on cultured mammalian cells.
Plasmacytoma cells exposed to heparin exhibited zeiotic blebs in the G1 phase, S phase, and early G2 phase. Zeiosis was not seen in mitotic cells. This heparin effect was reversible. Also fibroblasts were sensitive to heparin. After trypsinization of fibroblasts, heparin produced large non-reversible zeiotic blebs in the cells, except in those in mitosis. The primary target for heparin is apparently to be sought among components of the cellular periphery.
D000818:Animals; D002478:Cells, Cultured; D005347:Fibroblasts / Q000187:drug effects*; D006493:Heparin / Q000494:pharmacology*; D051379:Mice; D008938:Mitosis; D010954:Plasmacytoma
D006493:Heparin