title: A single dose study of trazodone with an assessment of its effect on mood and arousal.
abstract: 1 A pharmacokinetic study of a single oral dose of a new antidepressant (trazodone) is described, linked to an attempt to measure changes in mood and arousal induced by the drug in normal subjects. 2 The drug had a measurable effect on arousal, but not on mood. It caused bradycardia (compared with placebo) and this persisted through the following night's sleep. This effect has not been completely explained. 3 The technique of mood and arousal measurement employed in this study seems potentially useful.
mesh_terms: D000328:Adult; D001143:Arousal / Q000187:drug effects*; D004644:Emotions / Q000187:drug effects*; D005260:Female; D006207:Half-Life; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D008297:Male; D010879:Piperazines / Q000494:pharmacology*; D010919:Placebos; D011619:Psychotropic Drugs; D014196:Trazodone / Q000378:metabolism / Q000494:pharmacology*
chemical_list: D010879:Piperazines; D010919:Placebos; D011619:Psychotropic Drugs; D014196:Trazodone