The influence of phentolamine on the central activity of 5-hydroxytryptamine in rat.
PHENT (20 and 100 mug ivc) affects the central action of 5-HT (0-1, 25 and 250 mug) in rats which shows itself in potentiation of 5-HT-induced inhibition of spontaneous locomotor and exploratory activities and in the prolongation of hexobarbital sleeping time. In case of postamphetamine hyperactivity and body temperature, 5-HT acts antagonistically to a lower PHENT dose and synergistically to a higher dose of this compound. No affect of 5-HT on a slight antistereotypy action of PHENT has been stated. Neither compound affects electrical seizures.
D000818:Animals; D001831:Body Temperature / Q000187:drug effects; D001921:Brain / Q000502:physiology*; D003913:Dextroamphetamine / Q000494:pharmacology; D004597:Electroshock; D005106:Exploratory Behavior / Q000187:drug effects; D006801:Humans; D008297:Male; D009043:Motor Activity / Q000187:drug effects; D010646:Phentolamine / Q000494:pharmacology*; D051381:Rats; D012640:Seizures / Q000503:physiopathology; D012701:Serotonin / Q000502:physiology*; D012890:Sleep / Q000187:drug effects; D013239:Stereotyped Behavior / Q000187:drug effects
D012701:Serotonin; D003913:Dextroamphetamine; D010646:Phentolamine