title: Synthesis and biological actions of 2-substituted quinolizidines.
abstract: A series of 2-substituted quinolizidines was synthesized and tested for their effects on motor activity in mice. In the 2-aryl-2-hydroxyquinolizidines (5 and 6) a difference was noted in potency between the axial and equatorial aryl analogs. A significant difference in activity was also found between the epimeric 2-(4-fluorobenzoyl) quinolizidines (10c and 11c).
mesh_terms: D000818:Animals; D004353:Drug Evaluation, Preclinical; D007928:Lethal Dose 50; D008297:Male; D051379:Mice; D009043:Motor Activity / Q000187:drug effects; D011807:Quinolizines / Q000138:chemical synthesis* / Q000494:pharmacology / Q000633:toxicity; D051381:Rats; D013237:Stereoisomerism; D013329:Structure-Activity Relationship
chemical_list: D011807:Quinolizines