Reduction in the cholinesterase activity of the rat anococcygeus muscle produced by corticosterone.
1 Administration of corticosterone caused a 47% reduction in the cholinesterase (ChE) activity of homogenates of the rat anococcygeus muscle. 2 ChE activity was also reduced by morphine withdrawal and this effect was abolished by the corticosteroid synthesis inhibitor, metyrapone. 3 A single dose of reserpine reduced ChE activity in normal but not in adrenalectomized rats. 4 ChE activity was increased by adrenalectomy or by metyrapone treatment. 5 The mechanism of the corticosteroid-induced reduction in ChE activity is discussed. 6 The reduction in ChE activity produced by corticosterone, morphine withdrawal, or a single dose of reserpine might explain the leftward shift of the dose-% response curve to acetylcholine produced by these procedures in the isolated anococcygeus muscle of the rat.
D000311:Adrenal Glands / Q000502:physiology; D000315:Adrenalectomy; D000818:Animals; D002802:Cholinesterases / Q000378:metabolism*; D003345:Corticosterone / Q000097:blood / Q000494:pharmacology*; D003864:Depression, Chemical; D006801:Humans; D066298:In Vitro Techniques; D008297:Male; D008797:Metyrapone / Q000494:pharmacology; D009020:Morphine; D009132:Muscles / Q000201:enzymology*; D051381:Rats; D012110:Reserpine / Q000494:pharmacology; D013375:Substance Withdrawal Syndrome / Q000378:metabolism
D009020:Morphine; D012110:Reserpine; D002802:Cholinesterases; D003345:Corticosterone; D008797:Metyrapone