Effect of clozapine on 5-HIAA excretion in urine and CSF of psychotic patients and on serotonin metabolism in rat brain.
In a clinical study and with experiments in rats Clozapine showed a sedative effect, which diminished during the treatment, and indicated a development of tolerance. 5-HIAA in urine and CSF of patients was elevated after 10 days of treatment. 5-HT and 5-HIAA were elevated in the brains of rats in acute experiments as well as in chronic experiments.
D000818:Animals; D001921:Brain / Q000187:drug effects / Q000378:metabolism*; D002940:Circadian Rhythm; D003024:Clozapine / Q000494:pharmacology; D003984:Dibenzazepines; D006801:Humans; D006897:Hydroxyindoleacetic Acid / Q000097:blood / Q000378:metabolism* / Q000652:urine; D008297:Male; D011618:Psychotic Disorders / Q000378:metabolism*; D051381:Rats; D012701:Serotonin / Q000378:metabolism*; D012894:Sleep Stages
D003984:Dibenzazepines; D012701:Serotonin; D006897:Hydroxyindoleacetic Acid; D003024:Clozapine