[A loop technique for permanent exteriorization of bile flow in rats (author's transl)].
A technique of chronic deviation of the bile flow without affecting either hepatic or pancreatic function is described in the rat. Two silastic tubes are inserted into the bile duct via a single incision, one directed towards the liver and the other towards the duodenum. Using a trocar, the two tubes are brought forward subcutaneously, exteriorized over the frontal region and connected by a polythene U-tube. They are encased in a plastic cylinder firmly fixed to the skull with dental cement, and fitted with a cap. This permits repeated sampling and simultaneous measurement of flow and pressure of bile in unrestrained animals for a least one month. The entero-hepatic bile salt cycle and the animal's weight are unmodified by this procedure.
D000818:Animals; D001646:Bile / Q000502:physiology*; D003135:Common Bile Duct; D007440:Intubation / Q000379:methods / Q000662:veterinary*; D008297:Male; D051381:Rats / Q000502:physiology*
Technique de dérivation chronique du canal cholédoque chez le rat