The effects of dexamethasone and starvation on body composition and regional adipose tissue cellularity in the rat.
In order to examine regional effects of corticosteroids on the depot fat distribution a dose of dexamethasone that produced changes in fat cell weight (40 mug per kg per day) was administered to rats. Starved rats were included for comparison. Starvation caused a decrease in depot fat and fat cell weight proportional to the characteristic fat cell weight of that region. In comparison with the changes found in the depots of pair-fed rats the effects of dexamethasone in this dose were largely the same. The epididymal adipocytes behaved differently and were emptied more slowly than their weight indicated.
D000273:Adipose Tissue / Q000166:cytology / Q000187:drug effects*; D000818:Animals; D001823:Body Composition / Q000187:drug effects*; D002452:Cell Count; D003864:Depression, Chemical; D003907:Dexamethasone / Q000494:pharmacology*; D004822:Epididymis / Q000166:cytology / Q000187:drug effects; D008297:Male; D051381:Rats; D013217:Starvation; D013997:Time Factors; D014280:Triglycerides / Q000378:metabolism
D014280:Triglycerides; D003907:Dexamethasone