[Effect of cholinesterase inhibitors and reactivators on the blocking action of dicarboxylic acid amino esters on neuromuscular conduction].
Inhibition of active cholinesterases in cats with armine or the GT-165 compound (0,0-diethyl-S-/beta-arylmethylamino) ethyl/thiophosphate methylsulphomethylate) potentiases ten- and hundred-fold the blocking action of subecholine and its derivatives on the neuro-muscular condution. The cholinesterase reactivator dipyroxime (2-5 mg/kg) quickly lifts the conduction block, provoked by muscle relaxants of the subecholine type under the cholinesterase inhibition. The subecholine analogue with a single propyl radical at each atom of nitrogen does not display any pressor action and, upon inhibition of cholinesterases, it blocks the neuro-muscular conduction when used in a dose of 0.1-0.2 gamma/kg. The maximal potentiation of the blocking action exerted by subecholine and its analogues is achieved in inhibiting not only pseudocholinesterase but acetylcholinesterase as well.
D000600:Amino Acids, Dicarboxylic / Q000494:pharmacology*; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D002415:Cats; D002794:Choline / Q000031:analogs & derivatives / Q000494:pharmacology; D002800:Cholinesterase Inhibitors / Q000494:pharmacology*; D002801:Cholinesterase Reactivators / Q000494:pharmacology*; D002802:Cholinesterases / Q000097:blood; D003998:Dicarboxylic Acids / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D004357:Drug Synergism; D004952:Esters; D005260:Female; D008297:Male; D009119:Muscle Contraction / Q000187:drug effects*; D009132:Muscles / Q000201:enzymology; D009431:Neural Conduction / Q000187:drug effects; D009596:Nitrophenols / Q000494:pharmacology; D009943:Organophosphorus Compounds / Q000494:pharmacology; D009946:Organothiophosphorus Compounds / Q000494:pharmacology; D013329:Structure-Activity Relationship; D014289:Trimedoxime / Q000494:pharmacology
D000600:Amino Acids, Dicarboxylic; D002800:Cholinesterase Inhibitors; D002801:Cholinesterase Reactivators; D003998:Dicarboxylic Acids; D004952:Esters; D009596:Nitrophenols; D009943:Organophosphorus Compounds; D009946:Organothiophosphorus Compounds; C009335:subecholine; D014289:Trimedoxime; D002802:Cholinesterases; D002794:Choline
Vliianie ingibitorov i reaktivatorov kholinésteraz na blokiruiushchee deístvie aminoéfirov dikarbonovykh kislot na nervno-myshechnoe provedenie