[Effect of delagil and hydrocortisone on specific lymphocyte blast transformation in vitro].
The effect of delagil (chloroquine) and of hydrocortisone taken in different concentration on the lymphocytes blast-transformation reaction in donors, stimulated with streptococcal nucleoprotein, was enquired into. Differences in the action of drugs on this reaction were uncovered, viz. delagil suppressed the specific stimulation of lymphocytes in all cases, both in therapeutic and toxic concentrations of it in the culture medium, whereas hydrocortisone inhibited the bacterial stimulation only in one half of instances and in the others--intensified it. The inhibitory effect of hydrocortisone gained in strength with its elevated concentration in the culture medium.
D002478:Cells, Cultured; D002738:Chloroquine / Q000494:pharmacology*; D003864:Depression, Chemical; D004305:Dose-Response Relationship, Drug; D006801:Humans; D006854:Hydrocortisone / Q000494:pharmacology*; D007111:Immunity, Cellular / Q000187:drug effects; D008213:Lymphocyte Activation / Q000187:drug effects*; D009698:Nucleoproteins / Q000494:pharmacology; D013268:Stimulation, Chemical; D013291:Streptococcus
D009698:Nucleoproteins; D002738:Chloroquine; D006854:Hydrocortisone
Vliianie delagila i gidrokortizona na spetsificheskuiu blasttransformatsiiu limfotsitov in vitro