Multifocal fibrosis involving the thyroid, face, and orbits.
Our patient had fibrous thyroiditis with unusual facial and retroorbital fibrosis. Systemic fibrosis, which is more typical of the multifocal fibrosclerosing syndromes, was not evident. Treatment with steroid alone, surgery, and radiotherapy failed to maintain a remission. The combination of steroid and cyclophosphamide therapy appears to have been successful.
D001847:Bone Diseases / Q000150:complications / Q000188:drug therapy / Q000473:pathology / Q000532:radiotherapy; D003520:Cyclophosphamide / Q000627:therapeutic use; D003907:Dexamethasone / Q000627:therapeutic use; D005145:Face / Q000473:pathology; D005260:Female; D006801:Humans; D008875:Middle Aged; D009915:Orbit / Q000473:pathology; D012867:Skin / Q000473:pathology; D012871:Skin Diseases / Q000150:complications* / Q000188:drug therapy / Q000473:pathology / Q000532:radiotherapy; D013961:Thyroid Gland / Q000473:pathology; D013966:Thyroiditis / Q000150:complications* / Q000188:drug therapy / Q000532:radiotherapy
D003907:Dexamethasone; D003520:Cyclophosphamide