[Erythrocyte changes of membrane proteins in some hemoglobinopathies].
The electrophoretic behaviour of red cell membrane proteins was studied in thalassaemia major and minor and in sickle-cell anaemia. Protein amino acid composition was also determined following hot hydrolysis of the stromas. Experiments with various solubilisation methods, electrophoresis supports and buffers showed certain changes in these three diseases, accompanied by alterations of the percent ratio of some amino acids.
D000596:Amino Acids / Q000032:analysis; D000755:Anemia, Sickle Cell / Q000097:blood; D002462:Cell Membrane / Q000378:metabolism; D004591:Electrophoresis, Polyacrylamide Gel; D004912:Erythrocytes / Q000378:metabolism*; D006453:Hemoglobinopathies / Q000097:blood*; D006801:Humans; D011506:Proteins / Q000378:metabolism*; D013103:Spherocytosis, Hereditary / Q000097:blood; D013789:Thalassemia / Q000097:blood
D000596:Amino Acids; D011506:Proteins
Alterazioni eritrocitarie delle proteine di membrana in alcune emoglobinopatie