[Effect of sulpiride and 2Br-alfa ergocryptine on the neuroendocrine control of hPRL incretion (author's transl)].
The incretion was studied in eight male normal subjects control of hPRL incretion. The incretion of hPRL after infusion of SULPIRIDE (100 mg) by e.v. was studied in eight male normal subjects. Three days later the load of sulpiride was repeated after pretreatment (two hours) with C.B.-154 (2,5 mg). After CB-154 pretreatment the levels of hPRL were significantly lower. Cb-154 is able to reduce incretion of hPRL, also after stimulation with Sulpiride by double mechanism.
D004873:Ergolines / Q000494:pharmacology*; D006801:Humans; D009489:Neurosecretion / Q000187:drug effects; D009490:Neurosecretory Systems / Q000502:physiology*; D010902:Pituitary Gland / Q000502:physiology; D011388:Prolactin / Q000378:metabolism*; D012636:Secretory Rate / Q000187:drug effects; D013469:Sulpiride / Q000494:pharmacology*
D004873:Ergolines; D013469:Sulpiride; D011388:Prolactin
Azione della sulpiride e del 2-Br-alfa-ergocriptina sul controllo neuroendocrino della increzione di prolattina (PRL)