Dobutamine and general anaesthesia: a study of the response of arterial pressure, heart rate and renal blood flow.
The effects of dobutamine, a new catecholamine, have been studied during anaesthesia with halothane, halothane and nitrous oxide and alphaprodine. Renal blood flow is increased by dobutamine as are mean arterial pressure and heart rate. The increase in rate is less marked during alphaprodine anaesthesia than when halothane is administered. Dobutamine may prove a useful agent in the management of acute circulatory failure but it is capable of inducing dysrhythmias under the conditions of these experiments.
D000522:Alphaprodine / Q000008:administration & dosage; D000818:Animals; D001145:Arrhythmias, Cardiac / Q000139:chemically induced; D002395:Catecholamines / Q000494:pharmacology*; D004280:Dobutamine / Q000009:adverse effects / Q000494:pharmacology*; D004285:Dogs; D006221:Halothane / Q000008:administration & dosage; D006339:Heart Rate / Q000187:drug effects*; D007668:Kidney / Q000098:blood supply*; D009609:Nitrous Oxide / Q000008:administration & dosage; D010197:Pancuronium / Q000494:pharmacology; D012039:Regional Blood Flow / Q000187:drug effects; D013874:Thiopental / Q000008:administration & dosage; D014403:Tubocurarine / Q000494:pharmacology
D002395:Catecholamines; D000522:Alphaprodine; D004280:Dobutamine; D010197:Pancuronium; D013874:Thiopental; D009609:Nitrous Oxide; D006221:Halothane; D014403:Tubocurarine