Effect of two long acting injectable progestogens on lactation in the human.
The effects of Depoprovera and Deladroxone were studied in humans, on certain milk components as well as on the growth of the nursed infants. Both drugs caused reduction in milk yield. Both drugs caused an increase in the concentration of milk total proteins, however. Depoprovera caused an increase while Deladroxone caused a decrease in the total amount of milk proteins per feed. Depoprovera showed no effect while Deladroxone caused an increase in the concentration of milk lipids; however, both drugs caused reduction in the total amount of milk lipids per feed. Both drugs showed no effect on the concentration of milk lactose, but caused reduction in the total amount of milk lactose per feed. The percentage increase in weight of nursed infants was decreased by Depoprovera, but not affected by Deladroxone.
D000328:Adult; D000463:Algestone Acetophenide / Q000494:pharmacology*; D001942:Breast Feeding; D003692:Delayed-Action Preparations; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D007774:Lactation / Q000187:drug effects*; D008525:Medroxyprogesterone / Q000494:pharmacology*; D008894:Milk Proteins; D011247:Pregnancy
D003692:Delayed-Action Preparations; D008894:Milk Proteins; D008525:Medroxyprogesterone; D000463:Algestone Acetophenide