[The effects of elevated calcium concentrations in artificial cerebrospinal fluid on pial arteries during perivascular microperfusion and the Ca++-antagonistic effect of bencyclane (author's transl)].
The influence of artificial cerebrospinal fluid (CSF) containing 6, 9 and 18 mEq/l Ca++, respectively, on 145 pial arteries of nine anesthetized cats was investigated by the perivascular microperfusion technique. The higher the concentration of Ca++ in the perivascular space and the longer these high Ca++ concentrations acted on the vascular wall, the more pronounced were the constrictions of the arteries. If N-[3-(1-benzyl-cycloheptyloxy)-propyl]-N,N-dimethyl-amine (bencyclane-hydrogenfumarate, Fludilat) (10 mg/100 ml) was added to the CSF, dilatations occurred, even if the concentrations of Ca++ were higher than in normal CSF (3 meq/l). The degree of dilatation, however, was dependent on the Ca++ concentration in the CSF. With high Ca++ in the CSF the dilatatory action of bencyclane was inhibited when K+ and H+ in the CSF were kept constant. The reaction can be described as Ca++ antagonism, the possible mechanisms of which are discussed.
D000818:Animals; D001158:Arteries / Q000187:drug effects; D001537:Bencyclane / Q000494:pharmacology*; D002118:Calcium / Q000037:antagonists & inhibitors / Q000134:cerebrospinal fluid* / Q000494:pharmacology; D002415:Cats; D003508:Cycloheptanes / Q000494:pharmacology*; D005260:Female; D008297:Male; D009119:Muscle Contraction / Q000187:drug effects*; D009130:Muscle, Smooth / Q000187:drug effects*; D010477:Perfusion; D010841:Pia Mater / Q000098:blood supply*; D013997:Time Factors
D003508:Cycloheptanes; D001537:Bencyclane; D002118:Calcium
Die auswirkungen erhöhter Kalziumkonzentrationen im künstlichen Liquor cerebrospinalis auf die Piagefässweite bei perivaskulärer Mikroperfusion und die Hemmwirkung durch Bencyclan