Detection of private and common tumor-associated antigens in murine sarcomas induced by different chemical carcinogens.
Two fibrosarcomas of similar histological type, induced in C3Hf mice by either methylcholanthrene or 3,4-benz(a)pyrene, were shown to have individually unique tumor-rejection antigens in classical transplantation-type experiments. By contrast, sera of autochthonous mice, which resisted only transplants of the immunizing sarcoma, were found to contain complement-dependent cytotoxic antibodies, specific for both sarcomas, in vitro. The existence of individually unique as well as common tumor-associated antigens in chemically-induced murine sarcomas is suggested. The private "tumor transplantation-type" antigens elicited tumor rejection responses in vivo. The common tumor-associated antigens, although immunogenic in autochthonous hosts, inducing the production of tumor-specific antibodies, failed to induce transplantation cross-resistance in vivo. This study supports the contention that, in carcinogen-induced murine tumors, and perhaps in human neoplasms as well the evaluation of humoral (and cell-mediated) immune responses in vitro may not reflect tumor rejection-type immune responses in vivo.
D000818:Animals; D000951:Antigens, Neoplasm; D001580:Benzopyrenes; D005354:Fibrosarcoma / Q000139:chemically induced / Q000276:immunology*; D007114:Immunization; D008325:Mammary Neoplasms, Experimental / Q000276:immunology; D008748:Methylcholanthrene; D051379:Mice; D008809:Mice, Inbred C3H; D009368:Neoplasm Transplantation; D012513:Sarcoma, Experimental / Q000139:chemically induced / Q000276:immunology*; D014181:Transplantation Immunology; D014184:Transplantation, Homologous
D000951:Antigens, Neoplasm; D001580:Benzopyrenes; D008748:Methylcholanthrene