Granulocyte kinetics in donors undergoing filtration leukapheresis.
Normal blood donors undergoing filtration leukapheresis (FL) have a profound transient neutropenia early in the procedure which is followed by a "rebound" neutrophilia. This phenomenon occurs in unstimulated donors as well as in donors pretreated with either prednisone or dexamethasone. The mechanism for development of the neutropenia was investigated in volunteers throug a nylon filter at 37 C, a significant but transient neutropenia was observed. Plasma rendered cell and stroma-free achieved the same result indicating that plasma alone, when exposed to nylon fibers, is capable of producing neutropenia.
D001782:Blood Donors; D001804:Blood Transfusion, Autologous; D003165:Complement System Proteins; D003907:Dexamethasone / Q000627:therapeutic use; D005374:Filtration; D006098:Granulocytes / Q000187:drug effects / Q000502:physiology*; D006400:Hematocrit; D006801:Humans; D007700:Kinetics; D007958:Leukocyte Count; D007962:Leukocytes / Q000502:physiology*; D009503:Neutropenia / Q000209:etiology; D009757:Nylons; D011241:Prednisone / Q000627:therapeutic use; D011292:Premedication; D006435:Renal Dialysis / Q000009:adverse effects
D009757:Nylons; D003907:Dexamethasone; D003165:Complement System Proteins; D011241:Prednisone