Spasmogenic qualities of prostaglandin F2alpha in the cat.
Available data indicate that the concentration of prostaglandin F2alpha required to produce arterial spasm in an experimental model is approximately a thousand-fold higher than the concentration that occurs under physiological conditions. The spasmogenic platelet factor which has been previously described is shown to be a substance other than prostaglandin F2alpha because of differences in susceptibility of the two substances to enzymatic digestion.
D000818:Animals; D001488:Basilar Artery / Q000187:drug effects*; D002415:Cats; D004305:Dose-Response Relationship, Drug; D002546:Ischemic Attack, Transient / Q000139:chemically induced*; D011402:Pronase / Q000494:pharmacology; D011460:Prostaglandins F / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D014662:Vasoconstrictor Agents / Q000494:pharmacology*
D011460:Prostaglandins F; D014662:Vasoconstrictor Agents; D011402:Pronase