title: How does leukemia invade the central nervous system?
abstract: Prolongation of survival of children with acute leukemia by systemic therapy has brought a marded increase in incidence of CNS leukemia. In mice inoculated with leukemia cells, CNS i nfiltrates are rare unless life is prolonged by chemotherapy. Available evidence seems to indicate that leukemic cells in the CNS in most cases originate in bone marrow or lymph nodes.
mesh_terms: D000208:Acute Disease / Q000503:physiopathology*; D000818:Animals; D001853:Bone Marrow / Q000187:drug effects; D001854:Bone Marrow Cells; D002471:Cell Transformation, Neoplastic; D002648:Child; D006801:Humans; D007938:Leukemia / Q000150:complications / Q000188:drug therapy / Q000503:physiopathology*; D008214:Lymphocytes / Q000187:drug effects; D009360:Neoplastic Cells, Circulating; D051381:Rats