title: [Introduction to new research on correlations between manic-depressive psychosis and adult obesity-linked diabetes].
abstract: The problem of the association between adult diabetes, obesity and manic-depressive psychosis is examined in the light of new endocrinological and psychopharmacological findings. After a critical review of the vast old and recent literature on the matter, a physiopathological interpretation of the clinical association is put forward on the basis of mental, nervous and endocrine correlations in carbohydrate metabolism, with special reference to manic-depressive psychosis. The insulin-like effect of lithium on carbohydrate metabolism and correlated ions (phosphates, calcium, magnesium, potassium) at cell membrane level is then discussed. Theoretical and practical conclusions are drawn on the basis of these data. The former propose an essentially "structural" or "intersection" hypothesis of the association and suggest depth study of the insulin function especially in the "normal" phase of manic-depressive psychosis. The latter show the possibility of a clinical trial with lithium and other anti-depressant drugs in obese diabetics, with a close cooperation between psychiatrist and diabetologist.
mesh_terms: D000328:Adult; D000367:Age Factors; D001714:Bipolar Disorder / Q000188:drug therapy / Q000209:etiology* / Q000378:metabolism; D050260:Carbohydrate Metabolism; D048909:Diabetes Complications; D003920:Diabetes Mellitus / Q000378:metabolism; D006801:Humans; D008094:Lithium / Q000627:therapeutic use; D009765:Obesity
chemical_list: D008094:Lithium
vernacular_title: Introduzione a nuove ricerche sulle correlazioni fra psicosi maniaco-depressiva e diabete adulto-obeso