Relative potency of tetrahydrocannabinol derivatives on tonic immobility in chickens.
Chickens were given varying dosages of delta 3-, delta 8-, and delta 9-THC and tested for duration of tonic immobility (TI). Although all derivatives had a profound facilitation effect, delta 9-THC was the most potent. These results are unusual in that TI is a well documented fear-potentiated reaction and THC generally has tranquilization-like effects.
D000818:Animals; D002188:Cannabis / Q000031:analogs & derivatives*; D002645:Chickens; D003864:Depression, Chemical; D013759:Dronabinol / Q000031:analogs & derivatives* / Q000494:pharmacology; D009068:Movement / Q000187:drug effects*; D013329:Structure-Activity Relationship
D013759:Dronabinol