Stimulation of insulin secretion in man by oral glycerol administration.
The effects of an orally administered glycerol load (1 g/Kg body weight) on blood glucose, plasma FFA, and plasma insulin levels have been determined in eight normal fasting or glucose loaded (1 g/Kg body weight) volunteers. Blood glucose levels were not affected by glycerol loading while glicemia followed the same pattern of a glucose tolerance test in the group treated with glucose plus glycerol. Plasma FFA were significantly lowered only 90 min after glycerol loading while they had markedly and persistently decreased by glycerol plus glucose per os. Finally, though glicemia did not change, insulinemia was markedly increased by glycereol, 90 min after loading; moreover, plasma IRI was significantly higher in the group treated with glycerol plus glucose than in the group treated with glucose alone. These data suggest that the release of insulin may be stimulated by a very small increment of blood glucose, which derives from glycerol.
D000328:Adult; D001786:Blood Glucose / Q000378:metabolism; D005215:Fasting; D005230:Fatty Acids, Nonesterified / Q000097:blood; D005260:Female; D005947:Glucose; D005990:Glycerol; D006801:Humans; D007328:Insulin / Q000097:blood*; D008297:Male
D001786:Blood Glucose; D005230:Fatty Acids, Nonesterified; D007328:Insulin; D005947:Glucose; D005990:Glycerol