title: Changes in drug metabolism with increasing age: 2. phenytoin clearance and protein binding.
abstract: 1 Comparison of phenytoin clearance showed a marked increase in people over 65 years of age compared with people under 45 years of age. 2 This difference was apparent if phenytoin was given orally or intravenously. 3 Phenytoin clearance correlated inversely with phenytoin binding and plasma albumin, both of which were found to be reduced in the elderly.
mesh_terms: D000328:Adult; D000368:Aged; D000375:Aging; D005260:Female; D006801:Humans; D008297:Male; D008657:Metabolic Clearance Rate / Q000187:drug effects; D010634:Phenobarbital / Q000494:pharmacology; D010672:Phenytoin / Q000378:metabolism*; D011485:Protein Binding; D012709:Serum Albumin / Q000032:analysis / Q000378:metabolism*
chemical_list: D012709:Serum Albumin; D010672:Phenytoin; D010634:Phenobarbital