On the antitumor activity of gallium and lanthanides.
When assayed on lymphatic leukemia BW5147 and lymphosarcoma 6C3HED bearing mice lanthanum shows a higher tumor inhibitory activity than does gallium. The mechanisms involved in the inhibition of the tumor growth appear related to effects of lanthanum and gallium on the tumor metabolism of calcium and magnesium.
D000818:Animals; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D002118:Calcium / Q000378:metabolism; D005260:Female; D005708:Gallium / Q000494:pharmacology / Q000627:therapeutic use*; D005998:Glycine / Q000627:therapeutic use; D007811:Lanthanum / Q000494:pharmacology / Q000627:therapeutic use*; D007942:Leukemia, Experimental / Q000188:drug therapy / Q000378:metabolism; D008274:Magnesium / Q000378:metabolism; D051379:Mice; D008806:Mice, Inbred AKR; D008809:Mice, Inbred C3H; D009374:Neoplasms, Experimental / Q000188:drug therapy* / Q000378:metabolism; D010758:Phosphorus / Q000378:metabolism; D013154:Spleen / Q000187:drug effects
D000970:Antineoplastic Agents; D010758:Phosphorus; D007811:Lanthanum; D005708:Gallium; D008274:Magnesium; D002118:Calcium; D005998:Glycine