Influence of benzodiazepines on turnover of serotonin in cerebral structures in normal and aggressive rats.
The influence of chlorodiazepoxide (CDP), oxazepam (OX), temazepam (TE) and nitrazepam (NI) on serotonin (5-HT) turnover in the brain stem and hypothalamus of normal and aggressive rats was studied on the basis of the rate of disappearance of 5-hydroxyindoleacetic acid (5-HIAA) after inhibition of MAO. Agressiveness in rats was induced by electric stimulation. All the tested compounds diminished 5-HT turnover in both cerebral structures in normal and aggressive rats. The strongest inhibition was produced by CDP in the brain stem of normal and hypothalamus of aggressive rats. The remaining substances acted with equal strength. Only OX had no influence on 5-HT turnover in the brain stem of aggressive rats.
D000374:Aggression / Q000187:drug effects; D000818:Animals; D001569:Benzodiazepines / Q000494:pharmacology*; D001933:Brain Stem / Q000378:metabolism* / Q000502:physiology; D006801:Humans; D007031:Hypothalamus / Q000378:metabolism* / Q000502:physiology; D008297:Male; D051381:Rats; D012701:Serotonin / Q000378:metabolism*; D013997:Time Factors
D001569:Benzodiazepines; D012701:Serotonin