title: [Effect of short-term fasting on liver lysosomes in rats, biochemical studies (preliminary report)].
abstract: The total activity of four lysosome enzymes--acid phosphatase, beta-glucuronidase, alpha-glucosidase and beta-N-acetylglucosaminidase--is studied in liver homogenate at 2, 6, 24 and 48 hours after the last meal in rats, previously sustained on a single-daily-feeding regimen. In addition, the free activity (percentage of the total) of the latter enzyme and its activity in the serum as well are investigated. A rise of the total activity of the first three enzymes is recorded within 48 hours after the beginning of starvation. The free activity of beta-N-acetylglucosaminidase shows an increase at 48 hours, while its activity in the serum--as early as 24 hours. The changes described above are interpreted as an expression of lysosome membrane permeability enhancement under fasting conditions.
mesh_terms: D000118:Acetylglucosaminidase / Q000378:metabolism; D000135:Acid Phosphatase / Q000378:metabolism; D000818:Animals; D004789:Enzyme Activation; D005215:Fasting; D005609:Free Radicals; D005959:Glucosidases / Q000378:metabolism; D005966:Glucuronidase / Q000378:metabolism; D008099:Liver / Q000201:enzymology* / Q000648:ultrastructure; D008247:Lysosomes / Q000201:enzymology*; D008297:Male; D051381:Rats; D013997:Time Factors
chemical_list: D005609:Free Radicals; D000135:Acid Phosphatase; D005959:Glucosidases; D005966:Glucuronidase; D000118:Acetylglucosaminidase
vernacular_title: Vliianie na kratkotraĭnoto gladuvane vurkhu lizozomite na cherniia drob u plukhove--biokhimichni izsledvaniia (predvaritelno suobshtenie).