title: 2,3-Dihydroxyphenethanolamine as an adrenergic agent.
abstract: In an attempt to further define the role of the m-hydroxy group in adrenergic agents, 2,3-dihydroxyphenethanolamine hydrobromide and N-isopropyl-2,3-dihydroxyphenethanolamine hydrobromide were prepared. These agents are less active than norepinephrine in alpha- and beta-adrenergic in vitro tests. The synthesis and conclusions from the tests are discussed.
mesh_terms: D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D002395:Catecholamines / Q000138:chemical synthesis* / Q000494:pharmacology; D002614:Chelating Agents; D003300:Copper; D004983:Ethanolamines / Q000138:chemical synthesis* / Q000494:pharmacology; D066298:In Vitro Techniques; D008297:Male; D009119:Muscle Contraction / Q000187:drug effects; D009130:Muscle, Smooth / Q000187:drug effects; D009638:Norepinephrine / Q000494:pharmacology; D051381:Rats; D013566:Sympathomimetics / Q000138:chemical synthesis*; D014649:Vas Deferens / Q000187:drug effects
chemical_list: D002395:Catecholamines; D002614:Chelating Agents; D004983:Ethanolamines; D013566:Sympathomimetics; D003300:Copper; D009638:Norepinephrine