[Study of the characteristics of transcortin and the progesterone binding protein of the plasma of pregnant guinea pig].
Experiments were conducted with the plasma of pregnant guinea pigs; it was shown that the corticosteroid-binding protein (CBP) of the plasma in a pregnant guinea pig (in difference from the CBP of other species) bound cortisol only, and not progesterone. Progesterone-binding protein (PBP) of these animals bound progesterone, but not glucocorticoids and their metabolites. The binding capacity of CBP proved to be several hundred microgram per cent of cortizol and of PBP--about 100 microgram per cent of progesterone. The association constant of the CBP with cortisol constituted 10(6) M-1, and of the PBP-10(-8) M-1. These proteins are also analysed according to a number of other parameters.
D000818:Animals; D005260:Female; D005938:Glucocorticoids / Q000097:blood; D006168:Guinea Pigs; D006854:Hydrocortisone / Q000097:blood; D011247:Pregnancy; D011374:Progesterone / Q000097:blood*; D011485:Protein Binding; D014156:Transcortin / Q000502:physiology*
D005938:Glucocorticoids; D011374:Progesterone; D014156:Transcortin; D006854:Hydrocortisone
Izuchenie kharakteristik transkortina i progesteronsviazyvaiushchego belka plazmy beremennoĭ morskoĭ svinki