Biogenesis of erythropoietin: evidence for pro-erythropoietin in a subcellular fraction of kidney.
The light mitochondrial fraction of hypoxic rodent kidneys, called the renal erythropoietic factor, contains erythropoietin in a pro, or active form. Erythropoietin is released from this inactive form when the renal erythropoietic factor is incubated with normal serum. The biogenesis of erythropoietin possibly involves a system in kidney reminiscent of the proinsulin-insulin system in pancreas.
D000818:Animals; D004921:Erythropoietin / Q000031:analogs & derivatives* / Q000096:biosynthesis* / Q000097:blood / Q000378:metabolism*; D005260:Female; D000860:Hypoxia / Q000378:metabolism; D007668:Kidney / Q000378:metabolism* / Q000648:ultrastructure; D051379:Mice; D011498:Protein Precursors / Q000378:metabolism*
D011498:Protein Precursors; D004921:Erythropoietin