title: Measurement of hepatic blood flow in the unanesthetized rabbit using 198Au and 125I Rose Bengal clearance technique.
abstract: Hepatic blood flow was measured in the unanesthetized rabbit using the clearance technique of 198Au and 125I RB. The values are: 71.82 +/- 16.24 ml-min-1-kg-1 for 198Au, and 60.21+/-9.94 ml-min-1-kg-1 for 125I RB (P less than 0.01). The overestimation of HBF with colloidal gold is probably due to extra splanchnic sequestration which has been estimated to be 15+/-3%. The week extraction of RB limits the use of this dye for measurements of HBF. HBF is easier to measure with 198 Au.
mesh_terms: D000818:Animals; D006050:Gold Radioisotopes; D007457:Iodine Radioisotopes; D008102:Liver Circulation; D011817:Rabbits; D012395:Rose Bengal
chemical_list: D006050:Gold Radioisotopes; D007457:Iodine Radioisotopes; D012395:Rose Bengal