Pulmonary embolism with factor XI deficiency.
A patient with factor XI deficiency had pulmonary embolism, although his factor XI assay was less than 1% of normal and his postoperative course was complicated by prolonged bleeding. Programs designed to prevent postoperative venous thrombosis should be carried out in factor XI-deficient patients, since the deficient state offers no protection from a pulmonary embolus. All surgical patients who are to receive low-dose heparin therapy as a part of such a program should be screened by means of preoperative determination of the partial thromboplastin time, to identify previously unsuspected bleeding disorders.
D000368:Aged; D001803:Blood Transfusion; D005173:Factor XI Deficiency / Q000097:blood / Q000150:complications* / Q000235:genetics; D006417:Hematuria / Q000209:etiology / Q000628:therapy; D006470:Hemorrhage / Q000209:etiology; D006493:Heparin / Q000627:therapeutic use; D006720:Homozygote; D006801:Humans; D008297:Male; D011468:Prostatectomy / Q000009:adverse effects; D011517:Prothrombin Time; D011655:Pulmonary Embolism / Q000097:blood / Q000150:complications*; D013924:Thrombophlebitis / Q000517:prevention & control
D006493:Heparin