title: Neurogenic influence on local cerebral blood flow. Effect of catecholamines or sympathetic stimulation as correlated with the sympathetic innervation.
abstract: Local cerebral flow was measured continuously in conscious rabbits (thermoclearance technique), and PaO2 and PaCO2 were recorded by mass spectrometry. Though inhalation of CO2 increased flow in caudate nucleus and lateral geniculate body, catecholamines only had effect on caudate nucleus where isoproterenol enhanced and epinephrine and norepinephrine reduced flow. Reduction by electrical stimulation of the neck sympathetic trunk was particularly evident in the caudate. Blood flow increased markedly in both regions after preganglionic conduction blockade. The effects were correlated with a significantly lower degree of sympathetic arteriolar innervation (fluorescence histochemistry) in the lateral geniculate body compared with the caudate nucleus.
mesh_terms: D000818:Animals; D001340:Autonomic Nerve Block; D001808:Blood Vessels / Q000294:innervation; D002245:Carbon Dioxide; D002395:Catecholamines / Q000494:pharmacology*; D002421:Caudate Nucleus / Q000032:analysis / Q000098:blood supply*; D002560:Cerebrovascular Circulation / Q000187:drug effects; D003714:Denervation; D003864:Depression, Chemical; D004558:Electric Stimulation; D004837:Epinephrine / Q000494:pharmacology; D005260:Female; D005725:Ganglia, Autonomic / Q000502:physiology; D005829:Geniculate Bodies / Q000032:analysis / Q000098:blood supply*; D007545:Isoproterenol / Q000494:pharmacology; D008297:Male; D009638:Norepinephrine / Q000494:pharmacology; D010101:Oxygen Consumption; D011817:Rabbits; D011941:Receptors, Adrenergic; D014666:Vasomotor System / Q000502:physiology*
chemical_list: D002395:Catecholamines; D011941:Receptors, Adrenergic; D002245:Carbon Dioxide; D007545:Isoproterenol; D009638:Norepinephrine; D004837:Epinephrine