Suppressant effects of alcohol on audiogenic seizures.
Genetically seizure susceptible DBA/1/Bg mice fed 10% ethanol in their drinking water exhibited a marked diurnal variation in blood alcohol levels. At peak levels, sound-induced seizures were significantly reduced. At trough levels, seizures remained unaffected. Ethanol administered during early development enhanced seizures at post-weaning age. Such alcohol-augmented seizures were suppressed by ethanol feeding during the testing period, to the same base level as in animals not pretreated with ethanol in early life.
D000161:Acoustic Stimulation; D000367:Age Factors; D000818:Animals; D002940:Circadian Rhythm; D003864:Depression, Chemical; D004327:Drinking Behavior; D000431:Ethanol / Q000097:blood / Q000494:pharmacology*; D005260:Female; D008297:Male; D051379:Mice; D008811:Mice, Inbred DBA; D012640:Seizures / Q000097:blood / Q000188:drug therapy*
D000431:Ethanol