[The effect of biologically active substances (acetylcholine, histamine and bradykinin) on depolarization of taenia coli smooth muscle].
In experiments on the isolated strips of Taenia coli of guinea pigs it was shown that compound D-600 depressed the acetylcholine (5-10(-6), histamine (2-10(-6) and bradykinin (10(-5) gl/ml)-induced contractile response of depolarized smooth muscle. Along with depression of the drug-induced response, compound D-600 depressed the "potassium contracture". It is supposed that the mentioned agents activated the inward flow of Ca2+ ions through the membrane, but not the release of these ions from the sarcoplasmic reticulum.
D000109:Acetylcholine / Q000494:pharmacology*; D000818:Animals; D001920:Bradykinin / Q000494:pharmacology*; D002118:Calcium / Q000378:metabolism; D003106:Colon / Q000187:drug effects; D005711:Gallopamil / Q000494:pharmacology; D006168:Guinea Pigs; D006632:Histamine / Q000494:pharmacology*; D009119:Muscle Contraction / Q000187:drug effects; D009130:Muscle, Smooth / Q000187:drug effects*; D011188:Potassium / Q000494:pharmacology; D012519:Sarcoplasmic Reticulum / Q000378:metabolism
D005711:Gallopamil; D006632:Histamine; D000109:Acetylcholine; D011188:Potassium; D001920:Bradykinin; D002118:Calcium
Vliianie biologicheski aktivnykh veshchestv (atsetilkholina, gistamine i bradikinina) na depoliarizovannuiu gladkuiu myshtsu taenia coli