Optic neuropathy presumably caused by vincristine therapy.
A 36-year-old man with Hodgkin's disease developed symmetric optic neuropathy after treatment with nitrogen mustard, vincristine, procarbazine, and prednisone. Histopathologic sections of the eyes showed loss of ganglion cells in the macular region and atrophy of the corresponding fibers in the optic nerve. Vincristine is presumed to have been the cause of the optic neuropathy because of its recognized neurotoxicity and its temporal relation to the onset of the visual complaint.
D000328:Adult; D004359:Drug Therapy, Combination; D006689:Hodgkin Disease / Q000188:drug therapy / Q000473:pathology; D006801:Humans; D008297:Male; D009901:Optic Nerve Diseases / Q000139:chemically induced* / Q000473:pathology; D014750:Vincristine / Q000009:adverse effects* / Q000627:therapeutic use
D014750:Vincristine