title: Chronic lymphadenopathic toxoplasmosis. A case with marked hyperglobulinemia and impaired delayed hypersensitivity responses during active infection.
abstract: A patient with lymphadenopathic toxoplasmosis characterized by prolonged symptoms and repeated relapses with isolation of toxoplasma from lymph nodes is described. As the disease persisted and progressed, striking immunologic changes occurred that ultimately resulted in a state of extreme hyperglobulinemia associated with impaired delayed hypersensitivity responses. The case in question illustrates that progressive infection may occur in the face of high antibody levels of all immunoglobulin types whereas the only demonstrable immunologic impairment was of delayed hypersensitivity.
mesh_terms: D000293:Adolescent; D000328:Adult; D002908:Chronic Disease; D003937:Diagnosis, Differential; D004137:Dinitrochlorobenzene; D006386:Hemagglutination Tests; D006801:Humans; D006942:Hypergammaglobulinemia / Q000209:etiology* / Q000276:immunology; D006968:Hypersensitivity, Delayed; D007244:Infectious Mononucleosis / Q000175:diagnosis; D008198:Lymph Nodes / Q000276:immunology; D008206:Lymphatic Diseases / Q000188:drug therapy / Q000276:immunology; D008297:Male; D011739:Pyrimethamine / Q000627:therapeutic use; D012882:Skin Tests; D013449:Sulfonamides / Q000627:therapeutic use; D014123:Toxoplasmosis / Q000175:diagnosis / Q000188:drug therapy / Q000276:immunology*
chemical_list: D004137:Dinitrochlorobenzene; D013449:Sulfonamides; D011739:Pyrimethamine