Ergoline congeners as potential inhibitors of prolactin release. 2.
In our attempts to elucidate the prolactin release inhibiting pharmacophore within the ergoline structure, we have prepared one indolealkylamine and several 2-aminotetralin derivatives. These congeners have been evaluated for inhibition of prolactin release in vivo. One congener, 5,8-dihydroxy-2-dimethylaminotetralin, and the drug M-7 significantly inhibited prolactin secretion.
D000818:Animals; D003864:Depression, Chemical; D004873:Ergolines / Q000138:chemical synthesis / Q000494:pharmacology*; D008297:Male; D011388:Prolactin / Q000037:antagonists & inhibitors / Q000097:blood / Q000378:metabolism*; D051381:Rats; D013329:Structure-Activity Relationship
D004873:Ergolines; D011388:Prolactin