Cephalexin-related nephropathy.
Hematuria and eosinophilia developed in two patients being treated for bacterial endocarditis with 20 or 24 gm/day of cephalexin given orally together with probenecid (Benemid). One patient had a concurrent transient increase in serum creatinine; both patients had a history of penicillin allergy and had previously received cephalexin intravenously. All abnormalities promptly remitted following discontinuation of therapy.
D000284:Administration, Oral; D000328:Adult; D002506:Cephalexin / Q000008:administration & dosage / Q000009:adverse effects* / Q000627:therapeutic use; D004342:Drug Hypersensitivity; D004696:Endocarditis / Q000188:drug therapy; D004802:Eosinophilia / Q000139:chemically induced* / Q000276:immunology; D006417:Hematuria / Q000139:chemically induced* / Q000276:immunology; D006801:Humans; D007674:Kidney Diseases / Q000139:chemically induced*; D008297:Male; D011339:Probenecid / Q000008:administration & dosage / Q000627:therapeutic use
D002506:Cephalexin; D011339:Probenecid