title: [Chemotherapeutic activity of bonafton in experimental herpetic keratitis in rabbits].
abstract: Bonaphthone (6-naphthoquinone-1,2) administered per os produces a prounced therapeutic effect in experimental herpetic keratitis of rabbits, induced by the virus of herpes simplex. With the topical appllication of bonaphthone in the form of an ointment the drug also produces a curative action in herpetic keratitis of rabbits. Combined application of bonaphthone locally and enterally in dealing with herpes in rabbits also acts beneficially, the same as its separate use.
mesh_terms: D000284:Administration, Oral; D000287:Administration, Topical; D000818:Animals; D000998:Antiviral Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D004353:Drug Evaluation, Preclinical; D004359:Drug Therapy, Combination; D007065:Idoxuridine / Q000627:therapeutic use; D007635:Keratitis, Dendritic / Q000188:drug therapy*; D009285:Naphthoquinones / Q000008:administration & dosage / Q000627:therapeutic use*; D009824:Ointments; D009883:Ophthalmic Solutions; D011817:Rabbits; D013997:Time Factors
chemical_list: D000998:Antiviral Agents; D009285:Naphthoquinones; D009824:Ointments; D009883:Ophthalmic Solutions; D007065:Idoxuridine
vernacular_title: Khimioterapevticheskaia aktivnost' bonaftona pri éksperimental'nom gerpeticheskom keratite krolikov