Treatment of autonomic dysreflexia with phenoxybenzamine.
Our 9 patients with severe autonomic dysreflexia treated with phenoxybenzamine, an alpha-sympatholytic agent, had a dramatic relief of symptoms. Bladder and urethral pressure studies before and after treatment with this agent suggest that the inappropriate rise in urethral resistance in these patients is a result of an appropriate but extraordinary response to bladder filling.
D001341:Autonomic Nervous System / Q000503:physiopathology; D005260:Female; D006801:Humans; D008297:Male; D010643:Phenoxybenzamine / Q000627:therapeutic use*; D012075:Remission, Spontaneous; D013119:Spinal Cord Injuries / Q000150:complications; D014521:Urethra / Q000503:physiopathology; D001743:Urinary Bladder / Q000503:physiopathology; D001750:Urinary Bladder, Neurogenic / Q000188:drug therapy* / Q000503:physiopathology; D014546:Urinary Catheterization
D010643:Phenoxybenzamine