title: [Ochronosis with severe arthropathy and internal organ lesions].
abstract: Observations upon a rarely met congenital disease is reported, developing symptomless up to the age of 40. The degenerative alterations of the big joints and the spine are of a special interest as well as the changes in urine, ear and nose cartilages, scleras and the skin in the armpits. A relation is supposed between the deposition of homogentisic acid and the functional changes in the vessels, latent diabetes and renal complaints.
mesh_terms: D002031:Bulgaria; D005132:Eye Manifestations; D005260:Female; D006801:Humans; D007592:Joint Diseases / Q000151:congenital / Q000503:physiopathology*; D007700:Kinetics; D008875:Middle Aged; D009794:Ochronosis / Q000151:congenital / Q000503:physiopathology*; D011674:Pulse
vernacular_title: Okhronoza s tezhka artropatiia i uvrezhdane na vutreshni organi