Response of the human nasal mucous membrane to anti-human IgE serum.
The response of the nasal mucous membrane to anti-human IgE serum was examined. The application of anti-IgE sera to the nasal mucous membrane induced a nasal allergy-like symptom as well as nasal eosinophilia. This symptom was observed in the majority of nasal allergy cases and in some vasomotor rhinitis cases, while not in non-allergic normal persons. The nasal eosinophilia, however, increased not only in allergic patients, but in non-allergic persons in whom no nasal symptoms were induced. Such a nasal reaction was not induced with anti-IgA sera or anti-IgG sera. The character of the reaction was presumed to be specific to anti-IgE and was predominantly a reversed type anaphylaxis in the nasal mucous membrane. The sensitivity of the nasal mucous membrane to anti-IgE decreased in the course of the hyposensitization with house dust. The cause of this phenomenon was obscure.
D000281:Administration, Intranasal; D000293:Adolescent; D000328:Adult; D001920:Bradykinin / Q000276:immunology; D002648:Child; D003888:Desensitization, Immunologic; D004391:Dust; D004804:Eosinophils; D005260:Female; D006801:Humans; D007106:Immune Sera / Q000008:administration & dosage; D007073:Immunoglobulin E / Q000008:administration & dosage; D008297:Male; D008875:Middle Aged; D009093:Mucus / Q000166:cytology; D009297:Nasal Mucosa / Q000276:immunology* / Q000378:metabolism; D006255:Rhinitis, Allergic, Seasonal / Q000276:immunology*
D004391:Dust; D007106:Immune Sera; D007073:Immunoglobulin E; D001920:Bradykinin