Hypersensitivity to procarbazine associated with angioedema, urticaria, and low serum complement activity.
Hypersensitivity to procarbazine associated with urticaria, angioedema, and painful joint swelling was found in a 20-year-old student being treated for Hodgkin's disease. A marked fall in complement component activity occurred simultaneously with the development of symtoms. It is suggested that generation of products of complement component activation could be important in the pathogenesis of hypersensitivity to some drugs.
D000328:Adult; D000799:Angioedema / Q000150:complications*; D003172:Complement C1 / Q000172:deficiency; D003175:Complement C2 / Q000172:deficiency; D003181:Complement C4 / Q000172:deficiency; D003165:Complement System Proteins / Q000172:deficiency*; D004342:Drug Hypersensitivity / Q000150:complications*; D006689:Hodgkin Disease / Q000188:drug therapy; D006801:Humans; D008297:Male; D011344:Procarbazine / Q000009:adverse effects* / Q000627:therapeutic use; D014581:Urticaria / Q000150:complications*
D003172:Complement C1; D003175:Complement C2; D003181:Complement C4; D011344:Procarbazine; D003165:Complement System Proteins