Chain elongation and desaturation of palmitic acid in liver microsomes of rats subjected to hyperbaric exposure.
The enzyme activities associated with chain elongation and desaturation of fatty acid in hepatic microsomes from rats held at 1 ATA of air, 1 ATA of He-O2, and 20 ATA of He-O2 were studied. It was found that both the microsomal chain elongation and desaturation of fatty acids were depressed in rats held at 1 ATA of He-O2 as compared to animals held at 1 ATA of air. When animals were exposed to an environment of 20 ATA of He-O2, the chain elongation of fatty acid was about the same as for rats held at 1 ATA of air and was two times greater than for the rats held at 1 ATA of He-O2. The desaturase activity was depressed as compared to the two groups of control animals held at 1 ATA of air and 1 ATA of He-O2.
D000399:Air Pressure; D000818:Animals; D001274:Atmospheric Pressure; D004242:Diving; D044943:Fatty Acid Desaturases / Q000378:metabolism; D006371:Helium; D008297:Male; D008862:Microsomes, Liver / Q000201:enzymology / Q000378:metabolism*; D010084:Oxidation-Reduction; D010100:Oxygen; D010169:Palmitic Acids / Q000378:metabolism*; D051381:Rats
D010169:Palmitic Acids; D006371:Helium; D044943:Fatty Acid Desaturases; D010100:Oxygen