[Irreversible degradation rate of free essential amino acids in vivo].
A method for determining "in vivo" the irreversible degradiation rate of essential free amino acids has been described. This rate of degradation is not uniform from one amino acid to the other, but is specific for each one. It can be modified by food intake. Under the influence of a moderate quantity of growth hormone the irreversible degradation rate of six amino acids (Ileu, Leu, Met, Phe, Thr and Val) was significantly decreased. This does explain the general anabolizing effect of the hormone. The administration of moderate quantities of coritsone has a specific effect on the degradation of essential free amino acids; it increases the rate of degradation of Met, Thr and Val but the rate of degradation of Ileu was unchanged. Therefore the catabolic effect of cortisone could presumably be explained by an accelerated rate of degradation of some essential free amino acids.
D000601:Amino Acids, Essential / Q000378:metabolism*; D000818:Animals; D003348:Cortisone / Q000494:pharmacology; D004032:Diet; D013006:Growth Hormone / Q000494:pharmacology; D009584:Nitrogen / Q000378:metabolism; D051381:Rats; D013912:Threonine / Q000378:metabolism; D014633:Valine / Q000172:deficiency
D000601:Amino Acids, Essential; D013912:Threonine; D013006:Growth Hormone; D014633:Valine; D009584:Nitrogen; D003348:Cortisone
Recherches sur la vitesse de la dégradation irréversible in vivo des acides aminés essentiels libres