[Teratogenic action of ethyl-nitrosourea in Göttingen miniature pigs (author's transl)].
By i.p. application of 70 or 100 mg/kg ethyl-nitrosourea, resp., to gravide Göttingen miniature pigs on days 14 or 16, resp., of gestation massive malformations of the skeletal system were produced. The experiments demonstrated the teratogenic effect of ethylnitrosourea on non-rodents, ascertained the period of determination of the skeletal system in pigs, confirmed the concentration effect in teratogenesis as well as the ineffectiveness of biological barriers with adequately high dosages.
D000014:Abnormalities, Drug-Induced / Q000209:etiology*; D000818:Animals; D001846:Bone Development / Q000187:drug effects*; D005038:Ethylnitrosourea / Q000494:pharmacology*; D005260:Female; D005552:Forelimb / Q000002:abnormalities; D005865:Gestational Age; D008437:Maxilla / Q000002:abnormalities; D009607:Nitrosourea Compounds / Q000494:pharmacology*; D011247:Pregnancy; D013131:Spine / Q000002:abnormalities; D013552:Swine; D013723:Teratogens
D009607:Nitrosourea Compounds; D013723:Teratogens; D005038:Ethylnitrosourea
Teratogene Wirkung von Athyl-nitrosoharnstoff an Göttinger Miniaturschweinen