title: Plasma and tissue iron changes in the rat after acute administration of ethionine.
abstract: 1. Ethionine administered acutely to the adult female rat markedly elevates and then lowers plasma iron concentration over several days. Liver iron undergoes a reverse cycle. 2. Ethionine does not cause changes in the blood parameters, including total plasma iron-binding capacity and plasma iron clearance. Erythrocytes of rats injected with ethionine show altered responses to hypertonicity. 3. Increased reticulo-endothelial activity of the spleen, indicated by increased uptake of 59Fe-labelled erythrocytes by liver and spleen, apparently contributes to plasma iron elevation. Also the liver releases iron which further raises plasma iron.
mesh_terms: D000818:Animals; D004912:Erythrocytes / Q000187:drug effects / Q000378:metabolism; D005001:Ethionine / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D005260:Female; D007501:Iron / Q000097:blood / Q000378:metabolism*; D008099:Liver / Q000187:drug effects / Q000378:metabolism; D009996:Osmotic Fragility / Q000187:drug effects; D051381:Rats; D013154:Spleen / Q000187:drug effects / Q000378:metabolism; D013997:Time Factors; D014168:Transferrin / Q000378:metabolism
chemical_list: D014168:Transferrin; D007501:Iron; D005001:Ethionine