[Study of the mechanism of postcoital contraception in the combination of streoids and the central m-cholinolytic, amizil].
Experiments on female rats showed the blocking of the M-cholinoreactive system with amizyl to significantly contribute to the estrogen/norsteroid contraceptive effect during the postcoital periods. This effect was accompanied by decrease in the gonadotropin level and by the change in the LH/FSH ratio, this creating an unfavourable background for implantation of the fertilized ovicell in the endometrium. There was a change in the transport rate in the tube and a delay in the decidual reaction. Changes in the rate of the ovicell transport were not accompanied by distrubances in the process of fertilization or with the cytotoxic action. Mestranol and ethynylestradiol in combination with norethynodrel (1:20) and with the  central cholinolytic amizyl were agents with future prospects for short-term postcoital contraception.
D000818:Animals; D001535:Benactyzine / Q000494:pharmacology*; D003281:Contraceptives, Postcoital / Q000494:pharmacology*; D003282:Contraceptives, Postcoital, Hormonal / Q000494:pharmacology*; D003283:Contraceptives, Postcoital, Synthetic / Q000494:pharmacology*; D004338:Drug Combinations; D010064:Embryo Implantation / Q000187:drug effects; D004971:Estrus / Q000187:drug effects; D004997:Ethinyl Estradiol / Q000494:pharmacology; D005260:Female; D005306:Fertilization / Q000187:drug effects; D005640:Follicle Stimulating Hormone / Q000097:blood; D005859:Germany, East; D007986:Luteinizing Hormone / Q000097:blood; D008656:Mestranol / Q000494:pharmacology; D009640:Norethindrone / Q000494:pharmacology; D009641:Norethynodrel / Q000494:pharmacology; D010063:Ovum / Q000187:drug effects; D010276:Parasympatholytics / Q000494:pharmacology*; D011247:Pregnancy; D051381:Rats; D013997:Time Factors; D014586:USSR
D003281:Contraceptives, Postcoital; D003282:Contraceptives, Postcoital, Hormonal; D003283:Contraceptives, Postcoital, Synthetic; D004338:Drug Combinations; D010276:Parasympatholytics; D004997:Ethinyl Estradiol; D001535:Benactyzine; D009641:Norethynodrel; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone; D008656:Mestranol; D009640:Norethindrone
Izuchenie mekhanizma postkoital'noĭ kontratseptsii pri sochetanii steroidov i tsentral'nogo m-kholinolitika amizila