[Cardiovascular effects of direct action of potassium and calcium ions on the hypothalamus].
In experiments on adult rats, using the stereotaxic technique of cannulas implantation, the changes in arterial pressure, contraction rate and bioelectric activity of the heart were studied by means of introducing small doses of potassium and calcium chlorides into the zones of the anterior and posterior hypothalamus and into the CSF of the 3rd ventricle of the brain. The injections of potassium chloride were found to produce an elevation of the arterial pressure, tachycardia and irregular changes in the voltage and pattern of the waves of the ventricular complex of ECG; similar injections of the structures of the anterior hypothalamus to the action of calcium was noted, while the posterior appeared more sensitive to potassium. It was concluded that direct stimulations of the posterior hypothalamic structures with potassium and calcium ions produce a more lasting tonic effect on the haemodynamics than their effect upon the anterior hypothalamus. It is suggested that the hypothalamus is an important level of not only the reflex, but also of the direct neurogenic regulation of the haemodynamic parameters.
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D002118:Calcium / Q000008:administration & dosage / Q000494:pharmacology*; D006339:Heart Rate / Q000187:drug effects; D006439:Hemodynamics / Q000187:drug effects*; D007031:Hypothalamus / Q000187:drug effects*; D007276:Injections, Intraventricular; D011189:Potassium Chloride / Q000008:administration & dosage / Q000494:pharmacology*; D051381:Rats
D011189:Potassium Chloride; D002118:Calcium
Serdechno-sosudistye effekty priamogo deĭstviia ionov kaliia i kal'tsiia na gipotalamus