The acute and chronic bronchodilator effects of ephedrine in asthmatic patients.
In eight asthmatic patients, there was no change in the bronchodilator response to a single dose of ephedrine (22 mg) given alone or in a compound tablet, after treatment with ephedrine (11 mg three times a day) or one tablet three times a day for 2 weeks. 2 There was no deterioration in lung function during the 2 week treatment period with either ephedrine or the compound tablet. 3 An inter-patient variation was noted in the plasma ephedrine concentraition required for bronchodilatation. 4 The half-life of theophylline did not change after chronic treatment with the tablets, one three times a day for 2 weeks.
D000284:Administration, Oral; D001249:Asthma / Q000503:physiopathology*; D001794:Blood Pressure / Q000187:drug effects; D001993:Bronchodilator Agents; D004334:Drug Administration Schedule; D004338:Drug Combinations; D004809:Ephedrine / Q000008:administration & dosage / Q000097:blood / Q000494:pharmacology*; D005541:Forced Expiratory Volume; D006207:Half-Life; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D010366:Peak Expiratory Flow Rate; D010634:Phenobarbital / Q000494:pharmacology; D013806:Theophylline / Q000097:blood / Q000494:pharmacology; D014797:Vital Capacity
D001993:Bronchodilator Agents; D004338:Drug Combinations; D013806:Theophylline; D004809:Ephedrine; D010634:Phenobarbital