Augmentation of cytotoxic drug action and X-irradiation by antibodies.
The effect of an antiserum containing antibodies against cell surface components of PyBHK cells on the action of certain anticancer agents has been studied using a colony formation inhibition assay. The effects of x-rays, chlorambucil, CCNU and possibly ICRF 159 are augmented by the antiserum whereas methotrexate and vinblastine are not.
D000912:Antibodies, Neoplasm / Q000008:administration & dosage; D000970:Antineoplastic Agents / Q000494:pharmacology*; D002455:Cell Division / Q000187:drug effects / Q000528:radiation effects; D002460:Cell Line; D002462:Cell Membrane / Q000187:drug effects / Q000528:radiation effects; D002699:Chlorambucil / Q000494:pharmacology; D002999:Clone Cells; D008130:Lomustine / Q000494:pharmacology; D008727:Methotrexate / Q000494:pharmacology; D009374:Neoplasms, Experimental / Q000276:immunology; D011830:Radiation Effects; D011929:Razoxane / Q000494:pharmacology; D014747:Vinblastine / Q000494:pharmacology
D000912:Antibodies, Neoplasm; D000970:Antineoplastic Agents; D002699:Chlorambucil; D011929:Razoxane; D014747:Vinblastine; D008130:Lomustine; D008727:Methotrexate