The effects of hypophysectomy and of bovine growth hormone on the responses to testosterone of prostate, preputial, Harderian and lachrymal glands and of brown adipose tissue in the rat.
The relative responses to testosterone of the prostate, preputial, Harderian, and lachrymal glands, the seminal vesicles and the brown adipose tissue, have been compared in litter-mate, castrated and hypophysectomized-castrated rats, with or without treatment with bovine GH. The responses of both prostate and preputial glands, though not the seminal vesicles, were reduced by hypophysectomy, and restored by GH. Growth hormone had some independent action on the preputial glands, but most of its effect was synergistic with testosterone. The respinse of brown adipose tissue to testosterone was similarly reduced by hypophysectomy, but was not restored by the GH. The weights of the Harderian and lachrymal glands were not affected by castration, but they were considerably reduced by hypophysectomy. Growth hormone had a slight restorative effect on the Harderian glands, but none on the lachrymal glands.
D002001:Adipose Tissue, Brown / Q000187:drug effects*; D000311:Adrenal Glands / Q000187:drug effects; D000818:Animals; D002369:Castration; D002417:Cattle; D004357:Drug Synergism; D005837:Genitalia, Male / Q000187:drug effects*; D013006:Growth Hormone / Q000494:pharmacology*; D006243:Harderian Gland / Q000187:drug effects; D007016:Hypophysectomy; D007765:Lacrimal Apparatus / Q000187:drug effects*; D008297:Male; D009929:Organ Size / Q000187:drug effects; D010413:Penis / Q000187:drug effects; D010902:Pituitary Gland / Q000502:physiology*; D010903:Pituitary Gland, Anterior / Q000502:physiology*; D011467:Prostate / Q000187:drug effects; D051381:Rats; D012627:Sebaceous Glands / Q000187:drug effects; D012669:Seminal Vesicles / Q000187:drug effects; D013737:Testis / Q000502:physiology; D013739:Testosterone / Q000494:pharmacology*
D013739:Testosterone; D013006:Growth Hormone