Prostaglandins and pruritus.
We have found that pretreatment of human skin with prostaglandin E1 significantly lowers the threshold of human skin to itching evoked by both histamine and papain. Prostaglandins may thus potentiate pruritus in inflammatory skin disease, presumably by a non-specific effect on nerve-endings.
D000293:Adolescent; D000328:Adult; D000368:Aged; D004357:Drug Synergism; D006632:Histamine / Q000009:adverse effects; D006801:Humans; D008297:Male; D008875:Middle Aged; D010206:Papain / Q000009:adverse effects; D011458:Prostaglandins E / Q000009:adverse effects*; D011537:Pruritus / Q000139:chemically induced*
D011458:Prostaglandins E; D006632:Histamine; D010206:Papain