Granulomatous hepatitis, increased platelet aggregation, and hypercholesterolemia.
Two young patients presented with an unusual liver disease, granulomatous hepatitis with postnecrotic cirrhosis, and both underwent a splenorenal shunt procedure. Each developed an arterial embolic episode probably related to increased platelet aggregation. This represents the first report of a liver disease associated with increased platelet aggregation that was clinically significant, a myocardial infarction in one and a posterior cerebral infarction in the other. Also, unexpectedly, both patients became hypercholesterolemic after the splenorenal shunt was established.
D000293:Adolescent; D001921:Brain / Q000098:blood supply; D005260:Female; D006099:Granuloma / Q000097:blood / Q000150:complications*; D006505:Hepatitis / Q000097:blood / Q000150:complications*; D006801:Humans; D006937:Hypercholesterolemia / Q000209:etiology*; D007238:Infarction / Q000209:etiology; D008103:Liver Cirrhosis / Q000209:etiology; D009203:Myocardial Infarction / Q000209:etiology; D010974:Platelet Aggregation