[Electrophysiological bases of the antiarrhythmic activity of amiodarone (author's transl)].
The electrophysiological effects of orally administered Amiodarone (600 mg daily for 8 days) were evaluated using His bundle electrograms, the extrastimulus method and atrial pacing in 16 patients with proved ischemic heart disease. Our results show that Amiodarone: 1) does not affect sinus node activity; 2) considerably prolongs the refractory periods of the atrium; 3) slightly and inconsistently prolongs the refractory periods of the atrio-ventricular node and the intraventricular conduction system; 4) slightly decreases the atrio-ventricular conduction; 5) does not consistently depress the intraventricular conduction. These properties contribute to the explanation of the antiarrhythmic effects of the drug.
D000328:Adult; D000368:Aged; D000638:Amiodarone / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D001572:Benzofurans / Q000494:pharmacology*; D002036:Bundle of His / Q000187:drug effects; D003327:Coronary Disease / Q000188:drug therapy / Q000503:physiopathology; D004594:Electrophysiology; D005260:Female; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D008297:Male; D008875:Middle Aged
D001572:Benzofurans; D000638:Amiodarone
Basi elettrofisiologiche dell'attivita' antiaritmica dell'amiodarone