title: Relationship between hepatic mitochondrial oxidative metabolism and morphology during riboflavin deficiency and recovery in mice.
abstract: Changes in hepatic mitochondrial oxidative metabolism were examined during the development of severe riboflavin deficiency in mice, and during recovery from this deficiency. There was a marked reduction in oxidative rates for all substrates tested, with the decline being most pronounced with palmitoyl-1-carnitine. These effects were not enhanced by addition of galactoflavin to the riboflavin-deficient diet. Treatment of the deficient mice with riboflavin restored hepatic mitochondrial oxidation to normal within 24 hours in those mice fed a simple riboflavin-deficient diet, but required 72 hours in galactoflavin-supplemented mice. These metabolic changes in hepatic mitochondria appear to be temporally independent of the striking morphological changes occurring in these organelles during ariboflavinosis and recovery.
mesh_terms: D000818:Animals; D004376:Galactitol / Q000494:pharmacology; D008297:Male; D051379:Mice; D008930:Mitochondria, Liver / Q000187:drug effects / Q000378:metabolism* / Q000648:ultrastructure; D010085:Oxidative Phosphorylation; D012256:Riboflavin / Q000031:analogs & derivatives / Q000494:pharmacology / Q000627:therapeutic use; D012257:Riboflavin Deficiency / Q000188:drug therapy / Q000378:metabolism*
chemical_list: D004376:Galactitol; D012256:Riboflavin