Diacridines: bifunctional intercalators. II. The biological effects of putrescine, sperimidine and spermine diacridines on HeLa cells and on the L-1210 and P-388 leukemia cells.
The effect of putrescine, spermidine and spermine diacridines on the growth of HeLa cells and of P-388 and L-1210 leukemia cells has been evaluated and compared to that of the parent compound, 9-aminoacridine. The diacridines are more effective growth inhibitors than 9-aminoacridine. The primary site of action appears to be the inhibition of RNA synthesis.
D000166:Acridines / Q000494:pharmacology*; D000818:Animals; D002455:Cell Division / Q000187:drug effects; D006367:HeLa Cells / Q000187:drug effects / Q000378:metabolism*; D007939:Leukemia L1210 / Q000378:metabolism*; D007942:Leukemia, Experimental / Q000378:metabolism*; D051379:Mice; D014176:Protein Biosynthesis / Q000187:drug effects; D011700:Putrescine / Q000494:pharmacology*; D013095:Spermidine / Q000494:pharmacology*; D013096:Spermine / Q000494:pharmacology*; D013329:Structure-Activity Relationship
D000166:Acridines; D013096:Spermine; D013095:Spermidine; D011700:Putrescine