[Rodenticidal action of warfarin/4th communication: Binding to serum albumin of mice and rats (author's transl)].
The binding properties of 3-(1'-phenyl-2'-acetylethyl)-4-hydroxycoumarine (warfarin-Na) to serum albumin of mice and rats were determined by using the equilibrium dialysis. The binding percentage (beta), the binding capacity (K), and the association constant (K1) were calculated. The results are characteristic for a strong binding of warfarin to serum albumin of rats but only a small one to serum albumin of mice, caused probably by the different albumin structures of these species.
D000818:Animals; D003956:Dialysis; D004305:Dose-Response Relationship, Drug; D007700:Kinetics; D051379:Mice; D011485:Protein Binding; D051381:Rats; D012378:Rodenticides / Q000097:blood; D012709:Serum Albumin / Q000378:metabolism*; D013045:Species Specificity; D014859:Warfarin / Q000097:blood*
D012378:Rodenticides; D012709:Serum Albumin; D014859:Warfarin
Rodentizide Wirkung von Warfarin. 4. Bindung an Mäuse- und Rattenalbumin