Critical tests with oxibendazole against gastrointestinal parasites of ponies.
Twenty ponies were allotted to 4 groups of 5 ponies each, and oxibendazole was orally administered at dose levels of 5, 10, 15, and 20 mg/kg. In the 3 groups of ponies given the largest doses, efficacy against 3 species of Strongylus was between 92 and 100% and that against small strongylids of the genera Cyathostomum, Cylicocyclus, Cylicodontophorus, and Cylicostephanus was more than 99%. All adults and 95 to 100% of larvae of the pinworm Oxyuris equi were removed. In the group of ponies given 5 mg/kg, 86 to 100% of the large strongylids and 84 to 100% of the small strongylids were removed, as were all larval and adult pinworms. Trichostrongylus axei was found only in 4 of the 5 ponies given 5 mg/kg; results were encouraging, but not consistent. Almost all of the Parascaris equorum were found in this group of ponies; no anthelmintic activity was detected at this dose level. Oxibendazole removed approximately 99% of small strongylid 4th-stage larvae. No efficacy against the larval stages of Gasterophilus intestinalis and against Habronema spp and Setaria equina was observed.
D000818:Animals; D001562:Benzimidazoles / Q000627:therapeutic use*; D002219:Carbamates / Q000627:therapeutic use*; D006734:Horse Diseases / Q000188:drug therapy*; D006736:Horses; D007411:Intestinal Diseases, Parasitic / Q000188:drug therapy / Q000662:veterinary*; D008297:Male; D009349:Nematode Infections / Q000188:drug therapy / Q000662:veterinary*; D010123:Oxyuriasis / Q000188:drug therapy / Q000662:veterinary; D013272:Stomach Diseases / Q000188:drug therapy / Q000662:veterinary*; D013319:Strongyle Infections, Equine / Q000188:drug therapy
D001562:Benzimidazoles; D002219:Carbamates; C011321:oxibendazole