title: (Vinylaryloxy)acetic acids. A new class of diuretic agents. 2. (4-(3-Oxo-1-alkenyl)phenoxy)acetic acids.
abstract: A series of (E)-[4-(3-oxo-1-alkenyl)phenoxy]acetic acids was synthesized and tested in dogs for saluretic and diuretic properties. Several compounds exhibited noteworthy activity, e.g., (E)-[2,3-dichloro-4-(3-oxo-1-butenyl)phenoxy]acetic acid (3a). While possessing only half of the dose potency of ethacrynic acid (2), the active compounds act similarly to this diuretic in causing a prompt increase in the excretion of water and in the excretion of sodium and chloride ions in approximately equimolar amounts. Potassium ion excretion is increased but less markedly than sodium excretion.
mesh_terms: D000085:Acetates / Q000008:administration & dosage / Q000138:chemical synthesis* / Q000494:pharmacology; D000284:Administration, Oral; D000818:Animals; D002712:Chlorides / Q000652:urine; D004231:Diuresis / Q000187:drug effects; D004232:Diuretics / Q000008:administration & dosage / Q000138:chemical synthesis*; D004285:Dogs; D005260:Female; D006016:Glycolates / Q000138:chemical synthesis*; D007275:Injections, Intravenous; D009318:Natriuresis / Q000187:drug effects; D010642:Phenoxyacetates / Q000008:administration & dosage / Q000138:chemical synthesis* / Q000494:pharmacology; D011188:Potassium / Q000652:urine; D012964:Sodium / Q000652:urine; D013329:Structure-Activity Relationship; D014753:Vinyl Compounds / Q000008:administration & dosage / Q000138:chemical synthesis / Q000494:pharmacology
chemical_list: D000085:Acetates; D002712:Chlorides; D004232:Diuretics; D006016:Glycolates; D010642:Phenoxyacetates; D014753:Vinyl Compounds; D012964:Sodium; D011188:Potassium