Differential inhibition of embryonic cell aggregation by cultured human cells with "malignant" of "normal" characteristics.
The effect that cultured human cells have on chick embryonic neural retina cell aggregation was examined. Different types of human cultured cells inhibited aggregation of chick neural retinal cells to differetn degrees when mixed at a human cell:retina cell ration of 1:60. It appeared from the eleven cell lines studied that cells with "malignant" characteristics inhibited retinal cell aggregation to a greater extent than those with more "normal" characteristics. The assay could be used as a further test for abnormality of cell types and also as a method for studying the interactions of malignant cells with cultured cells.
D002449:Cell Aggregation; D002471:Cell Transformation, Neoplastic; D002478:Cells, Cultured; D006801:Humans