Complement-dependent immunoglobulin G receptor function in lymphoid cells.
Lymphoid cells are unable to lyse antibody-coated target cells in the presence of normal immunoglobulin G (IgG), presumably because their surface receptors of IgG are blocked. However, when target cells are sensitized with antibodies and complement, IgG receptors are unblocked and cytotoxicity occurs even in the presence of normal IgG. Thus, IgG receptors may function in vivo despite the relatively high concentations of IgG in serum and interstitial fluid.
D000936:Antigen-Antibody Complex; D003176:Complement C3 / Q000378:metabolism*; D003165:Complement System Proteins / Q000378:metabolism*; D003601:Cytotoxicity Tests, Immunologic; D007111:Immunity, Cellular; D007074:Immunoglobulin G / Q000378:metabolism*; D008214:Lymphocytes / Q000276:immunology; D008954:Models, Biological; D011955:Receptors, Drug
D000936:Antigen-Antibody Complex; D003176:Complement C3; D007074:Immunoglobulin G; D011955:Receptors, Drug; D003165:Complement System Proteins