Effect of metergoline, a specific serotonin antagonist, on human growth hormone response to arginine and L-dopa.
In seven normal subjects the repeated oral administration of metergoline, a specific antiserotonin agent, has enhanced HGH response to arginine infusion. Following placebo administration, arginine-induced HGH release was slightly but not significantly reduced; similarly, in eight metergoline treated subjects, HGH response to oral L-Dopa was slightly but not significantly reduced. HGH response to i.v. L-Dopa was not modified by the drug. These results suggest that serotonin controls HGH response only in response to arginine, not to L-Dopa.
D000293:Adolescent; D000328:Adult; D001120:Arginine / Q000494:pharmacology*; D004295:Dihydroxyphenylalanine / Q000494:pharmacology; D004873:Ergolines / Q000494:pharmacology*; D005260:Female; D013006:Growth Hormone / Q000097:blood*; D006801:Humans; D008297:Male; D008711:Metergoline / Q000494:pharmacology*; D008875:Middle Aged; D012702:Serotonin Antagonists
D004873:Ergolines; D012702:Serotonin Antagonists; D008711:Metergoline; D004295:Dihydroxyphenylalanine; D013006:Growth Hormone; D001120:Arginine