A study of a new bronchodilator: carbuterol.
A new oral bronchodilator, carbuterol, was studied in 9 subjects who had reversible airway obstruction. In addition to the spirometric changes, serial arterial blood gas determinations were done to see if the drug induced hypoxemia. Two- and 4-mg doses were compared with the placebo. There was a significant bronchodilating effect with the 4-mg dose beginning 30 min after administration of the drug. Maximal improvement of forced expiratory volume in 1 sec was observed at 4 hours, with a 42 per cent increase from the baseline. No significant hypoxemia was observed. The drug was considered an effective bronchodilating agent, with the effect lasting longer than 4 hours.
D000328:Adult; D000368:Aged; D001249:Asthma / Q000188:drug therapy*; D001993:Bronchodilator Agents / Q000627:therapeutic use*; D002245:Carbon Dioxide / Q000097:blood; D004983:Ethanolamines / Q000627:therapeutic use*; D005541:Forced Expiratory Volume; D006801:Humans; D008297:Male; D008875:Middle Aged; D010100:Oxygen / Q000097:blood; D010671:Phenylurea Compounds / Q000627:therapeutic use*
D001993:Bronchodilator Agents; D004983:Ethanolamines; D010671:Phenylurea Compounds; D002245:Carbon Dioxide; D010100:Oxygen