Interaction between lanthanum and calcium in isolated guinea-pig heart.
The effect of lanthanum ion on the contraction of the perfused guinea-pig heart has been investigated. Lanthanum caused inhibition of the contractile force. The dose-response curves suggest that there is more than one site with which lanthanum may interact. The high affinity interaction is antagonised by high external calcium. The possibility that a low concentration of lanthanum may block calcium entry into the myocardium is discussed.
D000818:Animals; D002118:Calcium / Q000008:administration & dosage / Q000494:pharmacology*; D003864:Depression, Chemical; D004305:Dose-Response Relationship, Drug; D004347:Drug Interactions; D005260:Female; D006168:Guinea Pigs; D006321:Heart / Q000187:drug effects*; D066298:In Vitro Techniques; D007811:Lanthanum / Q000494:pharmacology*; D008297:Male; D009200:Myocardial Contraction / Q000187:drug effects
D007811:Lanthanum; D002118:Calcium