title: Dextran-mediated interbacterial aggregation between dextran-synthesizing streptococci and Actinomyces viscosus.
abstract: Streptococcus sanguis and Streptococcus mutans bind to the surface of Actinomyces viscosus, producing large microbial aggregates. Aggregates form rapidly and are not easily dissociated by vigorous mixing. The binding is mediated by dextran. Glucose-grown streptococci will not aggregate unless they are first mixed with high-molecular-weight dextran. Aggregation is induced with dextrans isolated from Leuconostoc, S. sanguis, or S. mutans. Sucrose-grown streptococci will adhere to A. viscosus without the addition of an exogenous source of dextran. A. viscosus will bind dextran and then bind glucose-grown streptococci. Aggregation occurs over a wide pH range and is dependent on cations. The aggregating activity of A. viscosus is both protease and heat sensitive. The aggregating activity of S. sanguis is heat stable but sensitive to dextranase.
mesh_terms: D000190:Actinomyces / Q000378:metabolism*; D002449:Cell Aggregation / Q000187:drug effects; D002470:Cell Survival; D003910:Dextranase / Q000494:pharmacology; D003911:Dextrans / Q000096:biosynthesis / Q000494:pharmacology*; D010447:Peptide Hydrolases / Q000494:pharmacology; D013291:Streptococcus / Q000378:metabolism*; D013295:Streptococcus mutans / Q000378:metabolism*; D013298:Streptococcus sanguis / Q000378:metabolism*; D013395:Sucrose / Q000378:metabolism
chemical_list: D003911:Dextrans; D013395:Sucrose; D003910:Dextranase; D010447:Peptide Hydrolases