[Physiological significance of gastroduodenal blood flow and possibilities of its regulation by drugs].
The authors review the role of the gastroduodenal blood flow as a factor ensuring the secretory activity and protective properties of the gastric mucosa. The possibilities of its pharmacoregulation are also reviewed. It has been shown that the decrease of the gastric blood flow in experimental hemorrhagic shock, extravasal celiac artery stenosis, effects of indomethacin, vasopressin, etc. leads to ischemic injuries to the gastric mucosa accompanied by serious morphological and functional disturbances. The pathogenetic aspects of ischemic injuries to the stomach and duodenum are confirmed by the results of clinical examinations of patients with compression celiac artery stenosis and peptic ulcer. It has been noted that in these patients, the tissue blood flow in the mucosa in considerably decreased in the area of ulcerous defect. The lowering of the content of total phospholipids and changes in their composition were also observed both in relapse and after healing. Out of agents that improve peripheral circulation, propranolol, tavegil combined with cimetidine, trimin appeared most potent. These drugs regulate metabolic processes in gastric tissue, normalizing blood flow, reducing the content of histamine, serotonin, lipid peroxidation products, raising the level of total phospholipids and pepsin.
D000818:Animals; D002974:Clemastine / Q000494:pharmacology*; D004386:Duodenum / Q000098:blood supply* / Q000187:drug effects; D005753:Gastric Mucosa / Q000098:blood supply; D006634:Histamine H1 Antagonists / Q000494:pharmacology*; D006635:Histamine H2 Antagonists / Q000494:pharmacology*; D006801:Humans; D007413:Intestinal Mucosa / Q000098:blood supply; D011433:Propranolol / Q000494:pharmacology*; D051381:Rats; D012039:Regional Blood Flow / Q000187:drug effects*; D013270:Stomach / Q000098:blood supply* / Q000187:drug effects; D013276:Stomach Ulcer / Q000503:physiopathology; D014945:Wound Healing
D006634:Histamine H1 Antagonists; D006635:Histamine H2 Antagonists; D002974:Clemastine; D011433:Propranolol
Fiziologicheskoe znachenie gastroduodenal'nogo krovotoka i vozmozhnosti ego farmakoreguliatsii.