Cell kinetics and programmed chemotherapy for gynecologic cancer. I. Squamous-cell carcinoma.
The results of current investigation into cellular kinetics of both normal and abnormal human genital tissue have stimulated interest in programming chemotherapeutic drug regimens for the treatment of genital cancer. This report outlines the results of cell kinetic studies of normal and abnormal squamous epithelium of the female genital tract and presents preliminary results of a regimen utilizing methotrexate, hydroxyurea, and vincristine in patients with far-advanced squamous-cell cancer of the vulva, vagina, and cervix. A total of 92 patients have received 444 courses of programmed chemotherapy by either pelvic intra-arterial infusion or systemic administration of the drugs. Our results are presented and the theoretical basis of the research is discussed.
D002294:Carcinoma, Squamous Cell / Q000188:drug therapy / Q000473:pathology*; D002455:Cell Division; D004273:DNA, Neoplasm / Q000096:biosynthesis; D005260:Female; D005833:Genital Neoplasms, Female / Q000188:drug therapy / Q000473:pathology*; D006801:Humans; D006918:Hydroxyurea / Q000627:therapeutic use; D007700:Kinetics; D008727:Methotrexate / Q000627:therapeutic use; D002583:Uterine Cervical Neoplasms / Q000188:drug therapy / Q000473:pathology; D014625:Vaginal Neoplasms / Q000188:drug therapy / Q000473:pathology; D014750:Vincristine / Q000627:therapeutic use; D014846:Vulvar Neoplasms / Q000188:drug therapy / Q000473:pathology
D004273:DNA, Neoplasm; D014750:Vincristine; D006918:Hydroxyurea; D008727:Methotrexate