[Penicillin distribution in the body of animals with experimental chronic pneumonia when administered repeatedly in combination with prednisolone].
The dynamics of penicillin concentrations in the blood and lung tissue of animals with chronic experimental pneumonia after its repeated administration in combination with prednisolone was studied. An increase in the period, during which the antibiotic was found in the lung tissue of the animals under conditions of its repeated use with prednisolone was shown.
D000818:Animals; D001702:Biopharmaceutics; D001774:Blood Chemical Analysis; D002908:Chronic Disease; D004359:Drug Therapy, Combination; D008168:Lung / Q000032:analysis; D010400:Penicillin G / Q000008:administration & dosage / Q000378:metabolism; D010406:Penicillins / Q000378:metabolism*; D011014:Pneumonia / Q000188:drug therapy*; D011239:Prednisolone / Q000008:administration & dosage / Q000627:therapeutic use*
D010406:Penicillins; D011239:Prednisolone; D010400:Penicillin G
Raspredelenie penitsillina v organizme zhivotnykh s éksperimental'noĭ khronicheskoĭ pnevomonieĭ pri uslovii sochetannogo povtornogo vvedeniia ego s prednizolonom