title: [Electron microscopic examinations on foam cells in pigmented villonodular synovitis (PVS) (author's transl)].
abstract: The pathologic and histologic features of 17 cases of pigmented villonodular synovitis and bursitis are described. Similar lesions were induced in rabbit knee joints by injection of hypercholesterolaemic serum. A therory is presented that the inflammatory reaction is induced by release of cholesterol esters and crystals from foam cells in a manner similar to crystal-induced synovitis. It is theorized that a disturbance of cholesterol metabolism is responsible for the development of foam cells.
mesh_terms: D000328:Adult; D000368:Aged; D000818:Animals; D002062:Bursitis / Q000473:pathology; D002784:Cholesterol / Q000378:metabolism / Q000494:pharmacology; D005260:Female; D006615:Hip; D006801:Humans; D007223:Infant; D007717:Knee; D008297:Male; D008854:Microscopy, Electron; D008855:Microscopy, Electron, Scanning; D008875:Middle Aged; D010860:Pigments, Biological; D011817:Rabbits; D013583:Synovial Membrane / Q000473:pathology; D013585:Synovitis / Q000378:metabolism / Q000473:pathology*
chemical_list: D010860:Pigments, Biological; D002784:Cholesterol
vernacular_title: Elektronenmikroskopische Untersuchungen an Schaumzellen bei pigmentierter villonodulärer Synovitis (PVS))