[Effects of UV-radiation of different spectral composition on content of sterols in rat skin].
When irradiating rats with sources of UV-radiation of different spectral composition a decrease in a relative content of cholesterol is found in the animal skin. Simultaneously an increase in the content of such cholestorol biosynthesis precursors as lathosterol and 7-dehydrocholesterol is observed. The formation of cholesterol photooxidation products under the effect of UV-radiation in vivo is shown. The quantitative ratios of sterols under study depend on spectral characteristics of the applied UV-radiation sources. The cholesterol photooxidation products and antirachitic compounds formed in skin under the effect of UV-radiation are supposed to take part in inhibition of cholesterol biosynthesis.
D000818:Animals; D002784:Cholesterol / Q000378:metabolism; D011830:Radiation Effects; D051381:Rats; D012867:Skin / Q000378:metabolism / Q000528:radiation effects*; D013261:Sterols / Q000378:metabolism*; D014466:Ultraviolet Rays
D013261:Sterols; D002784:Cholesterol
Vpliv UF-viprominiuvannia riznoho spektral'noho skladu na vmist steriniv u shkiri shchuriv