Role of the kidneys in thrombopoietin production.
Extracts of plasma from normal rats, rats injected with rabbit anti-rat platelet serum (RARPS), nephrectomized rats and nephrectomized rats injected with RARPS were tested in thrombocytotic mice for the presence of thrombopoietin. Only fractions of plasma from unoperated rats that had been made thrombocytopenic by injection of RARPS gave positive results for thrombopoietin. The results suggest that the kidneys play a role in thrombopoietin production.
D000818:Animals; D001772:Blood Cell Count; D001792:Blood Platelets / Q000276:immunology; D006023:Glycoproteins / Q000378:metabolism*; D007668:Kidney / Q000378:metabolism / Q000502:physiology*; D008297:Male; D009392:Nephrectomy; D051381:Rats; D013926:Thrombopoietin / Q000378:metabolism*
D006023:Glycoproteins; D013926:Thrombopoietin