title: [Determination of the noradrenaline content and the noradrenaline metabolic rate in the brain of rats treated with lonetil].
abstract: Lonethyl1,2-methyl-3(para-etoxy-phanyl)-hynasolone-4, is an original Bulgarian preparation from the group of the tranquilizers. The authors examined its influence on the content of brain noradrenaline as well as on the velocity of noradrenaline exchange, which was the best index of sympathicus tonus. They used nonisotopic method of examining the velocity of noradrenaline exchange, which was based on measuring dimnution of the enodgenous mediator after blocking its biosynthesis. The studies were caried out on rats. The authors did not find changes both in the tissue concentration and in the velocity of noradrenaline exchange of animals, treated with lonethyl, which gave them foundation to include the preparation into the group of tranquilizers.
mesh_terms: D000818:Animals; D001921:Brain / Q000187:drug effects / Q000378:metabolism*; D001923:Brain Chemistry; D008297:Male; D008433:Mathematics; D008657:Metabolic Clearance Rate / Q000187:drug effects; D008702:Methaqualone / Q000031:analogs & derivatives* / Q000494:pharmacology; D009638:Norepinephrine / Q000032:analysis / Q000378:metabolism*; D051381:Rats; D013997:Time Factors
chemical_list: C012409:lonetil M3; D008702:Methaqualone; D009638:Norepinephrine
vernacular_title: Opredeliane sudurzhanieto na noradrenalin i skorostta na obmeniane na noradrenalin v mozuk na plukhove, tretrani s lonetil