Effect of renin-angiotensin system on sodium intake.
1. Water and saline intake was measured in rats depleted of Na by I.P. dialysis. Na intake was prevented 180 min but not 60-90 min after bilateral nephrectomy. Unilateral nephrectomy as well as ureteral ligature had no effect on Na intake. 2. Renin (3u.) injected I.P. re-established the Na appetite abolished by nephrectomy. 3. Angiotensin I (5 ng) or II (5-40 ng) injected into the 3rd ventricle, also restored the Na intake and this effect was dose-dependent. 4. The angiotensin converting-enzyme inhibitor Sq 20,881 (1 mg/kg) inhibited the effect of AI but not that of AII in restoring Na intake. 5. It is concluded that the kidneys might play a role in the regulation of Na intake through the renin-angiotensin system.
D000804:Angiotensin II / Q000008:administration & dosage / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D004435:Eating / Q000187:drug effects; D007276:Injections, Intraventricular; D007668:Kidney / Q000502:physiology*; D008026:Ligation; D009392:Nephrectomy; D012083:Renin / Q000494:pharmacology*; D012964:Sodium / Q000378:metabolism*; D013722:Teprotide / Q000494:pharmacology; D014546:Urinary Catheterization
D000804:Angiotensin II; D012964:Sodium; D013722:Teprotide; D012083:Renin