Synthesis and some pharmacological properties of (2-tryptophan)-oxytocin.
Previous studies have suggested that an aromatic amino acid residue at position 2 in oxytocin facilitates the expression of the hormone's biolgocial activities. [2-Tryptophan]-oxytocin, in which a residue of tryptophan has replaced that of tyrosine in oxytocin, has been synthesized by the method of azide coupling of the N-terminal dipeptide and C-terminal heptapeptide amide. It was found to have approximately 0.1% of the potency of oxytocin in milk ejection and uterotonic biological activities.
D000818:Animals; D055598:Chemical Phenomena; D002621:Chemistry; D005260:Female; D007774:Lactation / Q000187:drug effects; D008321:Mammary Glands, Animal / Q000187:drug effects / Q000378:metabolism; D051379:Mice; D008892:Milk / Q000378:metabolism; D010121:Oxytocin / Q000031:analogs & derivatives* / Q000138:chemical synthesis; D011247:Pregnancy; D013056:Spectrophotometry, Ultraviolet; D014364:Tryptophan
D010121:Oxytocin; D014364:Tryptophan