title: Computerized immunoblot analyses (CIBA) of the distribution of prekallikrein and its activation products in vivo and in vitro.
abstract: The distribution of prekallikrein and the complexes of kallikrein with C1 inhibitor (C1INH), alpha 2-macroglobulin and approximately 58-kDa protein(s) (e.g. antithrombin III), differs in normal and C1INH-deficient human plasma, activated in vitro, due to different C1INH levels. Different distribution in the deficient plasma activated in vivo or in vitro, suggests different rates of complex clearance.
mesh_terms: D000990:Antithrombin III / Q000378:metabolism; D003174:Complement C1 Inactivator Proteins / Q000172:deficiency / Q000378:metabolism; D003201:Computers; D004789:Enzyme Activation; D006801:Humans; D015151:Immunoblotting / Q000379:methods*; D066298:In Vitro Techniques; D007610:Kallikreins / Q000378:metabolism; D011288:Prekallikrein / Q000302:isolation & purification* / Q000378:metabolism; D000511:alpha-Macroglobulins / Q000378:metabolism
chemical_list: D003174:Complement C1 Inactivator Proteins; D000511:alpha-Macroglobulins; D000990:Antithrombin III; D011288:Prekallikrein; D007610:Kallikreins