Urinary calculus during methazolamide therapy.
A 68-year-old white man with Paget's disease and open-angle glaucoma was treated with methazolamide, 50 to 100 mg three times daily. Ten months after the medication was initiated he developed ureteral colic and a calcium oxalate stone was surgically removed. Three months after the drug was reinstituted the patient passed three calcium phosphate stones. This suggested a casual relationship between methazolamide and stone formation, although renal calculi also complicate Paget's disease and acetazolamide had been administered briefly.
D000086:Acetazolamide / Q000009:adverse effects / Q000627:therapeutic use; D000284:Administration, Oral; D000287:Administration, Topical; D000368:Aged; D004334:Drug Administration Schedule; D004359:Drug Therapy, Combination; D005901:Glaucoma / Q000188:drug therapy; D006801:Humans; D008297:Male; D008704:Methazolamide / Q000009:adverse effects* / Q000627:therapeutic use; D013830:Thiadiazoles / Q000009:adverse effects*; D014514:Ureteral Calculi / Q000139:chemically induced*
D013830:Thiadiazoles; D000086:Acetazolamide; D008704:Methazolamide