Structure-activity relationships of cyclic acetylcholine analogues of the piperidinol and thiacyclohexanol series.
The hydrochlorides and methiodides of 1-methyl-3- and 4-acetoxypiperidine and their sulphonium analogues are cholinergic agonists. They are substrates for acetylcholinesterase. The sulphonium compounds have a 78(-524)-fold higher activity than its nitrogen analogues.
D000109:Acetylcholine / Q000031:analogs & derivatives*; D000818:Animals; D003511:Cyclohexanols / Q000494:pharmacology*; D006168:Guinea Pigs; D008968:Molecular Conformation; D009119:Muscle Contraction / Q000187:drug effects; D009130:Muscle, Smooth / Q000187:drug effects*; D010880:Piperidines / Q000494:pharmacology*; D013329:Structure-Activity Relationship; D013452:Sulfonium Compounds / Q000494:pharmacology
D003511:Cyclohexanols; D010880:Piperidines; D013452:Sulfonium Compounds; D000109:Acetylcholine