Primary B cell lymphoma of the rectum in a patient coinfected with HIV-1 and HTLV-I.
This report describes a clinical case of a large cell, immunoblastic plasmacytoid malignant B-cell lymphoma of the rectum in an AIDS patient coinfected with HTLV-I. The malignant cells showed clonal genetic rearrangement of the HC (JH) and LCK genes. Infection by EBV was demonstrated serologically and with slot blots using genomic DNA of the cancer cells. Southern blot analysis with DNA extracted from the lymphoma cells were negative for HTLV-I. The patient received seven cycles of VACO-B which induced complete but transient clinical remission of the tumor. The final outcome of the patient is unknown.
D000163:Acquired Immunodeficiency Syndrome / Q000150:complications*; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D001761:Bleomycin / Q000008:administration & dosage; D003520:Cyclophosphamide / Q000008:administration & dosage; D004317:Doxorubicin / Q000008:administration & dosage; D005047:Etoposide / Q000008:administration & dosage; D015497:HIV-1 / Q000302:isolation & purification; D015490:HTLV-I Infections / Q000150:complications*; D004854:Herpesvirus 4, Human / Q000302:isolation & purification / Q000472:pathogenicity; D015368:Human T-lymphotropic virus 1 / Q000302:isolation & purification / Q000472:pathogenicity; D006801:Humans; D016483:Lymphoma, AIDS-Related / Q000150:complications* / Q000188:drug therapy / Q000382:microbiology; D016400:Lymphoma, Large-Cell, Immunoblastic / Q000150:complications* / Q000188:drug therapy / Q000382:microbiology; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local; D012004:Rectal Neoplasms / Q000150:complications* / Q000188:drug therapy / Q000382:microbiology; D012074:Remission Induction; D015163:Superinfection; D014412:Tumor Virus Infections / Q000150:complications; D014750:Vincristine / Q000008:administration & dosage
D001761:Bleomycin; D014750:Vincristine; D005047:Etoposide; D004317:Doxorubicin; D003520:Cyclophosphamide