The effect of simultaneous administration of levarterenol and phentolamine on renal blood flow.
The effect of simultaneous administration of levarterenol and phentolamine upon renal blood flow was studied over a 3-hour period in 22 mongrel dogs. The infusion of levarterenol alone produced a fall in renal blood flow that ranged from 28 to 58% from the baseline value. When both drugs were administered simultaneously, renal flow fell only 17 to 22% from baseline (p less than 0.05). From these studies we conclude that the simultaneous administration of levarterenol and phentolamine in optimal ratios maintains renal blood flow near baseline levels.
D000818:Animals; D001783:Blood Flow Velocity; D002302:Cardiac Output; D004285:Dogs; D004338:Drug Combinations; D007668:Kidney / Q000098:blood supply*; D009638:Norepinephrine / Q000494:pharmacology*; D010646:Phentolamine / Q000494:pharmacology*; D012039:Regional Blood Flow / Q000187:drug effects; D014655:Vascular Resistance / Q000187:drug effects
D004338:Drug Combinations; D009638:Norepinephrine; D010646:Phentolamine