Changes in the fine structure of venous endothelium in the rabbit following adrenaline infusion.
The fine structure of the endothelium lining the femoral and mesenteric veins in the rabbit was examined following the infusion of concentrations of adrenaline varying from 0.5 to 5.0 mug/kg. Control animals were infused with saline. Vesiculation of the endothelial cells was observed following each infusion of adrenaline, the effect being most marked with the highest dose used. It is suggested that this vesiculation may be associated with the release of antihaemophilic globulin and/or plasminogen activator from the endothelial cells.
D000818:Animals; D004727:Endothelium / Q000187:drug effects / Q000648:ultrastructure; D004837:Epinephrine / Q000494:pharmacology*; D005169:Factor VIII / Q000378:metabolism; D007263:Infusions, Parenteral; D010960:Plasminogen Activators / Q000378:metabolism; D011817:Rabbits; D014680:Veins / Q000187:drug effects* / Q000648:ultrastructure
D005169:Factor VIII; D010960:Plasminogen Activators; D004837:Epinephrine