[Effectiveness of sodium selenite in experimental liver dystrophy].
The effect of sodium selenite on the cholepoietic function of the liver in rats with acute dystrophy induced by carbon tetrachloride was studied. When used in doses of 1 and 10 gamma/100 g the drug was found to normalize the intensity of bile secretion, synthesis and secretion of bile acids and that of bilirubin, as well as excretion of cholesterol. This was attended by a rise of the cholate-cholesterol ratio.
D000208:Acute Disease; D000818:Animals; D001646:Bile / Q000187:drug effects / Q000378:metabolism; D001647:Bile Acids and Salts / Q000096:biosynthesis; D001663:Bilirubin / Q000378:metabolism; D002252:Carbon Tetrachloride Poisoning / Q000188:drug therapy; D002784:Cholesterol / Q000378:metabolism; D004353:Drug Evaluation, Preclinical; D008099:Liver / Q000187:drug effects; D008107:Liver Diseases / Q000188:drug therapy*; D008297:Male; D051381:Rats; D012636:Secretory Rate / Q000187:drug effects; D012643:Selenium / Q000494:pharmacology*; D013997:Time Factors
D001647:Bile Acids and Salts; D002784:Cholesterol; D012643:Selenium; D001663:Bilirubin
Effektivnost' selenita natriia pri éksperimental'noĭ distrofii pecheni