Effect of 6-hydroxydopamine on tumor growth.
The growth of C-1300 neuroblastoma was markedly slowed in 6-hydroxydopamine-treated mice. The growth of the A-10 breast adenocarcinoma was also significantly retarded in 6-hydroxydopamine-treated mice but the growth of B-16 melanoma was not affected. In mice axotomized by pretreatment with 6-hydroxydopamine, the growth of C-1300 neuroblastoma was slowed but the growth of the A-10 tumor was not affected. It is suggested that an intact functional sympathetic nervous system may be a factor that determines the rate of growth of certain tumors in vivo.
D000230:Adenocarcinoma / Q000188:drug therapy; D000818:Animals; D005260:Female; D006892:Hydroxydopamines / Q000627:therapeutic use*; D008297:Male; D008325:Mammary Neoplasms, Experimental / Q000188:drug therapy; D008545:Melanoma / Q000188:drug therapy; D051379:Mice; D008805:Mice, Inbred A; D008810:Mice, Inbred C57BL; D009374:Neoplasms, Experimental / Q000188:drug therapy*; D009447:Neuroblastoma / Q000188:drug therapy*; D013564:Sympathetic Nervous System / Q000503:physiopathology
D006892:Hydroxydopamines