In vitro lymphocyte stimulation by wart antigen in man.
The lymphocyte transformation test was used to study cell-mediated immunity to wart antigen in patients with active wart infections, in patients with past history of warts and in control subjects. A common pattern was established with wart antigen; a control baseline, followed by a rise of 14C thymidine uptake in the 'active' group and a further elevation in the 'past history' group. Five patients with active warts were followed up and re-examined at various intervals after successful wart resolution; all except one responded to wart antigen by increased DNA synthetic activity after the wart resolution. This increased response was specific for wart antigen and could still be detected 6 months after wart resolution.
D000293:Adolescent; D000328:Adult; D000368:Aged; D000956:Antigens, Viral; D005260:Female; D006358:Hot Temperature; D006801:Humans; D007111:Immunity, Cellular; D066298:In Vitro Techniques; D008213:Lymphocyte Activation; D008214:Lymphocytes / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D013936:Thymidine / Q000378:metabolism; D014860:Warts / Q000276:immunology*
D000956:Antigens, Viral; D013936:Thymidine