title: [The sensitivity of human melanoma heterotransplants to chemotherapeutic action].
abstract: There were revealed considerable individual differences in the sensitivity of human melanomas cultivated in diffusion chambers in the abdominal cavity of mice and the explants into the cheek pouches of Cricetus auratus W. to the combined action of three drugs: vincristin (or vinblastin), nitrosomethylurea, and dactinomycin. In comparing the results obtained in these two variants of investigations they proved to coincide in 3 of 5 cases. In 2 cases a negative result obtained in experimentas with Cricetus auratus W. corresponded to the positive result in experiments with diffuse chambers.
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D003609:Dactinomycin / Q000627:therapeutic use; D004359:Drug Therapy, Combination; D008545:Melanoma / Q000188:drug therapy*; D008770:Methylnitrosourea / Q000627:therapeutic use; D051379:Mice; D009368:Neoplasm Transplantation; D014183:Transplantation, Heterologous; D014747:Vinblastine / Q000627:therapeutic use; D014750:Vincristine / Q000627:therapeutic use
chemical_list: D000970:Antineoplastic Agents; D003609:Dactinomycin; D014750:Vincristine; D014747:Vinblastine; D008770:Methylnitrosourea
vernacular_title: Chuvstvitel'nost' geterotransplantatov melanom cheloveka k khimioterapevticheskomu vozdeĭstviiu