Efficacy studies on Haemophilus gallinarum bacterin preparations.
Broth cultures inactivated and potentiated by selected methods were tested in chickens for efficacy against homologous and heterologous challenge inoculation, using 2 serotype A strains of Haemophilus gallinarum. Although the 2 strains were within the same serotype, they failed to cross protect. One dose of thimerosal-inactivated bacterin was protective against homologous challenge, but 2 doses of formalin-inactivated bacterin were required. A bivalent bacterin protected chickens well against 1 strain, but not the other, at the 1-dose level.
D000818:Animals; D001428:Bacterial Vaccines / Q000008:administration & dosage; D002645:Chickens; D005557:Formaldehyde / Q000494:pharmacology; D006190:Haemophilus / Q000254:growth & development / Q000276:immunology*; D006192:Haemophilus Infections / Q000517:prevention & control / Q000662:veterinary; D011201:Poultry Diseases / Q000517:prevention & control; D013849:Thimerosal / Q000494:pharmacology
D001428:Bacterial Vaccines; D005557:Formaldehyde; D013849:Thimerosal