Immunity to monomorphic Trypanosoma brucei: humoral response.
Trypanosome-agglutinating antibodies, predominantly of the IgM class, are formed in T. brucei-infected rats cured with Berenil (diminazene). The duration of Berenil prophylaxis following administration of a minimum curative dose is approximately 28 days. Rechallenge of drug-cured animals with homologous organisms results in the production of IgG, indicating an apparent absence of interference under these conditions with B-cell, T-cell cooperativity.
D000818:Animals; D000917:Antibody Formation; D004133:Diminazene / Q000627:therapeutic use; D007074:Immunoglobulin G / Q000032:analysis; D008297:Male; D051379:Mice; D051381:Rats; D011919:Rats, Inbred Strains; D014346:Trypanosoma brucei brucei / Q000276:immunology*; D014352:Trypanosomiasis / Q000188:drug therapy / Q000276:immunology*
D007074:Immunoglobulin G; D004133:Diminazene