[Search for the substances selectively acting on the mediatory transmission of stimulatory amino acids].
The design of new compounds selectively acting on excitatory amino acid neurotransmission is discussed on the basis of structure-activity relationships. Some new compounds, derivatives of aspartic, glutamic, 2,3-diaminopropionic and some other acids, are cited as examples.
D000599:Amino Acids, Diamino / Q000494:pharmacology*; D001224:Aspartic Acid / Q000502:physiology*; D001921:Brain / Q000502:physiology*; D004341:Drug Evaluation; D005971:Glutamates / Q000502:physiology*; D018698:Glutamic Acid; D018377:Neurotransmitter Agents / Q000502:physiology*; D011422:Propionates / Q000494:pharmacology*; D018091:Receptors, AMPA; D017470:Receptors, Glutamate / Q000187:drug effects / Q000502:physiology*; D016194:Receptors, N-Methyl-D-Aspartate / Q000187:drug effects / Q000502:physiology*; D013268:Stimulation, Chemical; D009435:Synaptic Transmission / Q000187:drug effects / Q000502:physiology*
D000599:Amino Acids, Diamino; D005971:Glutamates; D018377:Neurotransmitter Agents; D011422:Propionates; D018091:Receptors, AMPA; D017470:Receptors, Glutamate; D016194:Receptors, N-Methyl-D-Aspartate; C100126:oxalyldiaminopropionic acid; D001224:Aspartic Acid; D018698:Glutamic Acid
Poisk veshchestv, izbiratel'no vliiaiushchikh na mediatornuiu peredachu vozbuzhdaiushchikh aminokislot.