title: Antibody response and resistance of turkeys to Newcastle disease vaccine strain LaSota.
abstract: Studies were undertaken to determine the influence of repeated revaccination on the immune response in immuno-competent turkeys as measured by humoral antibody and resistance to challenge. Protection was better in turkeys given the LaSota spray vaccine at 4 weeks and 30 days later than in turkeys given one vaccination by spray or intramuscular route or exposed 4 times at 10-day intervals by the aerosol route. The anamnestic response, as measured by the HI tests to revaccination with the same immunogen, was not evident by the 3rd day postrevaccination but was observed on the 7th day. The interval between primary and secondary vaccination was found to be important to a true and optimal anamnestic response. Response was greater, however, in vaccinated turkeys exposed to VVND, a more virulent virus antigenically different from the vaccine strain. Exposure to LaSota vaccine by the intramuscular route gave a poorer HI response than LaSota given by aerosol.
mesh_terms: D000818:Animals; D000917:Antibody Formation; D007156:Immunologic Memory; D009522:Newcastle disease virus / Q000276:immunology*; D014422:Turkeys / Q000276:immunology*; D014765:Viral Vaccines
chemical_list: D014765:Viral Vaccines