Renin-aldosterone axis in ethanol intoxication and hangover.
The renin-aldosterone system was studied in human volunteers during ethanol intoxication and hangover. Plasma renin activity increased more than 100%, when 1.5 - 2.3 g ethanol per kg body weight was ingested over a three hour period. During hangover the increase even exceeded 200%. Plasma aldosterone concentration decreased during ethanol intoxication, but increased greatly during hangover. It is suggested that the stimulation of the renin-aldosterone axis during ethanol intoxication and hangover is due to dehydration and increased activity of the sympathetic nervous system.
D000328:Adult; D000435:Alcoholic Intoxication / Q000097:blood*; D000450:Aldosterone / Q000097:blood*; D003681:Dehydration; D006801:Humans; D008297:Male; D009994:Osmolar Concentration; D011188:Potassium / Q000378:metabolism; D012083:Renin / Q000097:blood*; D012964:Sodium / Q000378:metabolism; D013997:Time Factors
D000450:Aldosterone; D012964:Sodium; D012083:Renin; D011188:Potassium