Uptake and metabolism in vivo of tritiated oestradiol-17beta in tissues of ageing female mice.
The uptake in vivo of tritiated oestradiol-17beta has been compared in young and aged ovariectomized CBA/H-T6 mice by examining the levels of radioactivity in tissues 1 h after injection. The specificity of oestradiol uptake was demonstrated by previous treatment of some animals with either diethylstilboestrol or progesterone. The levels of radioactivity in whole tissue extracts were similar in both age groups for the uterus, hypothalamus, cerebrum and serum, but the uptake in the pituitary gland was significantly lower in old mice. There was no evidence of altered hormone metabolism with age.
D000375:Aging; D000818:Animals; D001921:Brain / Q000378:metabolism; D004958:Estradiol / Q000378:metabolism*; D005260:Female; D007031:Hypothalamus / Q000378:metabolism; D051379:Mice; D008808:Mice, Inbred CBA; D010902:Pituitary Gland / Q000378:metabolism; D011374:Progesterone / Q000378:metabolism; D014599:Uterus / Q000378:metabolism
D011374:Progesterone; D004958:Estradiol