Antischistosomal and some toxicological properties of a nitrodiphenylaminoisothiocyanate (C 9333-Go/CGP 4540).
A procedure to enhance the schistosomicidal effectiveness in vivo of an isothiocyanate derivative and some of its antischistosomal properties are reported. Determinations of the effects of this compound on tissue thiol levels and on highly sensitivity bacterial tester strains have indicated that its mutagenic potential is of a low order and that the latter is decreased further after reduction of the host's intestinal bacterial flora.
D000814:Aniline Compounds / Q000627:therapeutic use*; D000818:Animals; D004159:Diphenylamine / Q000031:analogs & derivatives / Q000627:therapeutic use*; D004334:Drug Administration Schedule; D007422:Intestines / Q000382:microbiology; D017879:Isothiocyanates; D051379:Mice; D009153:Mutagens / Q000652:urine; D009154:Mutation / Q000187:drug effects; D012475:Salmonella / Q000187:drug effects; D012550:Schistosoma mansoni; D012552:Schistosomiasis / Q000188:drug therapy*; D012556:Schistosomicides; D013432:Sulfathiazoles / Q000627:therapeutic use; D013861:Thiocyanates / Q000627:therapeutic use*
D000814:Aniline Compounds; D017879:Isothiocyanates; D009153:Mutagens; D012556:Schistosomicides; D013432:Sulfathiazoles; D013861:Thiocyanates; D004159:Diphenylamine; C012391:amoscanate