The effect of meperidine analgesia on midtrimester abortions induced with intra-amniotic prostaglandin F2alpha.
To determine whether increased amounts of meperidine significantly affect the induction of abortion with intra-amniotic prostaglandin F2alpha, 42 midtrimester subjects were treated with an identical dose schedule of PFG2alpha and one of two dose schedules of meperidine. Although the group that received more mepridine reported severe pain less frequently, their mean and median induction-to-abortion times, cumulative abortion rate, uterine contractility, and complications were not significantly different from those of the group that received less meperidine.
D000028:Abortion, Induced / Q000009:adverse effects; D000293:Adolescent; D000328:Adult; D004716:Endometritis / Q000209:etiology; D005260:Female; D006801:Humans; D008614:Meperidine / Q000008:administration & dosage* / Q000627:therapeutic use; D010146:Pain / Q000188:drug therapy; D011247:Pregnancy; D011262:Pregnancy Trimester, Second; D011460:Prostaglandins F / Q000627:therapeutic use*; D013997:Time Factors; D014590:Uterine Contraction / Q000187:drug effects; D014592:Uterine Hemorrhage / Q000209:etiology
D011460:Prostaglandins F; D008614:Meperidine