Dermal cylindroma. Expression of intermediate filaments, epithelial and neuroectodermal antigens.
We report on immunohistochemical staining patterns in so-called apocrine tumors of skin with special emphasis on the dermal cylindroma. The results were compared with apocrine tubular adenoma, syringocystadenoma papilliferum and the normal eccrine sweat gland. A relationship of dermal cylindroma to the apocrine gland is suggested by expression of lysozyme and alpha 1-antichymotrypsin. The tumor shares keratin, epithelial membrane antigen (EMA) and EGF-receptor expression with eccrine and apocrine glands. The presence of intermingled cells with a coexpression of keratin and vimentin argues for a partial myoepithelia-like differentiation. Neuroectodermal antigens are missing. Therefore, dermal cylindroma is classified as an adnexal tumor of skin with a variable rate of cells of apocrine secretory, myoepithelial and undifferentiated phenotypes.
D000236:Adenoma / Q000378:metabolism / Q000473:pathology; D000912:Antibodies, Neoplasm / Q000276:immunology; D000951:Antigens, Neoplasm / Q000276:immunology*; D003528:Carcinoma, Adenoid Cystic / Q000378:metabolism / Q000473:pathology*; D003537:Cystadenoma / Q000378:metabolism / Q000473:pathology; D004439:Eccrine Glands / Q000473:pathology; D004475:Ectoderm / Q000276:immunology; D004848:Epithelium / Q000276:immunology / Q000473:pathology; D006801:Humans; D007150:Immunohistochemistry; D007381:Intermediate Filament Proteins / Q000096:biosynthesis*; D009474:Neurons / Q000276:immunology; D012878:Skin Neoplasms / Q000378:metabolism / Q000473:pathology*; D013194:Staining and Labeling
D000912:Antibodies, Neoplasm; D000951:Antigens, Neoplasm; D007381:Intermediate Filament Proteins