Influence of aspirin formulation and dose on concentration of total salicylate in rat kidney.
Rats received the equivalent of 100, 250, 500, or 700 mg/kg of 14C-aspirin orally as a suspension or as a solution of a buffered, effervescent, aspirin-containing product. Animals in each dose group were sacrificed at time intervals ranging from 0.5 to 24 hr after dosing. The 14C content of whole blood, plasma, and homogenized whole kidney (after perfusion) was determined. The concentration of total salicylate proved to be dose dependent and was lower in tissues from rats receiving the buffered, effervescent product, especially at the higher doses. The results suggest that salicylate-induced renal toxicity should be less likely to occur after administration of the buffered, effervescent formulation.
D000818:Animals; D001241:Aspirin / Q000097:blood / Q000378:metabolism*; D002021:Buffers; D007668:Kidney / Q000378:metabolism*; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D012459:Salicylates / Q000097:blood / Q000378:metabolism*; D013997:Time Factors
D002021:Buffers; D012459:Salicylates; D001241:Aspirin