title: Deposits of mucosubstances on the cornea by topical chloramphenicol: an electron microscopic study.
abstract: Chloramphenicol was instilled into rabbit eyes and five days later the corneal surface was examined by scanning electron microscopy. The corneal surface was roughened and showed a proliferative appearance. Examination of thin sections of the cornea by transmission electron microscope showed that the corneal surface stained strongly with alcian blue. It was thus supposed to be a deposit of mucosubstances. Mucosubstances increase pathogenicity of bacteria and, therefore, this deposit may accelerate Pseudomonas keratitis after chloramphenicol application.
mesh_terms: D000818:Animals; D002701:Chloramphenicol / Q000494:pharmacology*; D002923:Cilia / Q000648:ultrastructure; D003315:Cornea / Q000187:drug effects* / Q000648:ultrastructure; D009093:Mucus; D011817:Rabbits
chemical_list: D002701:Chloramphenicol