Cell cycle dependency of human sarcoma-associated tumor antigen expression.
An analysis of cell cycle-dependent expression of tumor-associated antigen was performed on a human neurosarcoma cell line (T2 cells). The expression of sarcoma-associated tumor antigen on T2 cells was detected using test sera obtained from sarcoma patients; control sera were from patients with nonsarcoma neoplasias and from normal donors. Results indicate a progressive increase in the antigenic expression beginning in late mitosis and early G1 with maximum expression in mid-G1. Antigenic expression declines to minimum levels in S and G2-phase. Mechanisms responsible for this cycle-dependent fluctuation are presently unknown.
D000912:Antibodies, Neoplasm / Q000032:analysis; D000918:Antibody Specificity; D000951:Antigens, Neoplasm / Q000032:analysis; D002455:Cell Division; D002460:Cell Line; D002462:Cell Membrane / Q000276:immunology; D003593:Cytoplasm / Q000276:immunology; D006801:Humans; D007106:Immune Sera; D007136:Immunoglobulins / Q000032:analysis; D007700:Kinetics; D008938:Mitosis; D009455:Neurofibroma / Q000276:immunology*
D000912:Antibodies, Neoplasm; D000951:Antigens, Neoplasm; D007106:Immune Sera; D007136:Immunoglobulins