title: Acquired resistance to ticks. I. Passive transfer of resistance.
abstract: Guinea-pigs developed resistance to larvae of the ixodid tick, Dermacentor andersoni, after one infestation. Resistance was characterized by guinea-pigs allowing fewer larvae to engorge (5-15%) during a second exposure than during an initial infestation (70-90%). Larvae feeding on resistant hosts weighed less than larvae engorging on a host with no previous exposure to ticks. Evidence is presented which indicates that this resistance can be passively transferred with viable lymph node cells, but not with serum, from resistant guinea-pigs. Recipients of cells from such resistant animals allowed significantly fewer larvae to engorge than did controls previously unexposed to ticks. This was not so in recipients of immune serum. The protection provided by passive transfer of cells from a resistant donor was not as complete as the protection afforded by natural exposure.
mesh_terms: D000818:Animals; D003870:Dermacentor / Q000276:immunology*; D006168:Guinea Pigs; D007106:Immune Sera; D007116:Immunization, Passive; D007814:Larva; D008198:Lymph Nodes / Q000276:immunology; D008214:Lymphocytes / Q000276:immunology; D013984:Tick Infestations / Q000276:immunology; D013987:Ticks / Q000276:immunology*
chemical_list: D007106:Immune Sera