Association of HLA-A3 and HLA-B14 antigens with idiopathic haemochromatosis.
The frequency of HLA-A3 and HLA-B14 antigens was significantly higher in a series of 51 patients with idiopathic haemochromatosis than in a control group, being respectively 78-4 versus 27-0% and 25-5 versus 3-4%. This finding strongly supports the suggestion that idiopathic haemochromatosis is a genetic disease and suggests that the gene(s) responsible for the disease may be linked to the histocompatibility genes.
D000328:Adult; D000483:Alleles; D005260:Female; D006680:HLA Antigens / Q000032:analysis / Q000302:isolation & purification*; D006432:Hemochromatosis / Q000235:genetics / Q000276:immunology*; D006649:Histocompatibility Antigens / Q000302:isolation & purification*; D006801:Humans; D008297:Male; D008875:Middle Aged
D006680:HLA Antigens; D006649:Histocompatibility Antigens