Antitumor activity of derivatives of mycophenolic acid.
One hundred and eight derivatives of mycophenolic acid (MA) have been prepared by modifications at the phenolic hydroxyl and/or carboxyl sites. None of these compounds was as effective as MA in suppressing cell growth of L-518Y cell in vitro, whereas several compounds with changes at both the hydroxyl and carboxyl groups were more effective than MA against Ehrlich solid carcinoma and L-1210 leukemia in mice.
D000818:Animals; D002286:Carcinoma, Ehrlich Tumor / Q000188:drug therapy; D007939:Leukemia L1210 / Q000188:drug therapy; D008297:Male; D051379:Mice; D009173:Mycophenolic Acid / Q000031:analogs & derivatives* / Q000627:therapeutic use
D009173:Mycophenolic Acid