Anaphylactoid reactions in connection with infusion of invert sugar solutions are due to macromolecular contaminants.
13 untoward mold anaphylactoid reactions were observed in patients infused with invert sugar solutions in Sweden during a 7-month period in 1973: an incidence of 1/31,000 infusions. Immunological and physicochemical analysis of invert sugar solutions and of the raw material, sucrose, revealed traces of native alpha-1,6-glucan with molecular weight of 10-100 millions as contaminant. This indicates, that the sucrose had been exposed to microbial contamination during its manufacture from sugar-beet or sugar-cane. Reversed single radial immunodiffusion was used for alpha-1,6-glucan detection and screening of all sucrose batches. Rejection of contaminated sucrose as raw material reduced the incidence of anaphylactoid invert sugar reactions to about 1/575,000 infusions. Examination of all sucrose raw material for traces of crude alpha-1,6-glucan is recommended as a test for detection of microbial contamination.
D000707:Anaphylaxis / Q000139:chemically induced*; D003911:Dextrans / Q000009:adverse effects; D004340:Drug Contamination; D006801:Humans; D046911:Macromolecular Substances; D013395:Sucrose / Q000009:adverse effects*
D003911:Dextrans; D046911:Macromolecular Substances; D013395:Sucrose