In vitro transmission and antigenicity of a retrovirus isolated from a multiple sclerosis patient.
We have recently isolated an apparently novel retrovirus (LM7) from a patient with multiple sclerosis (MS). We present here results showing that (1) LM7 retrovirus can be transmitted in vitro to a normal human leptomeningeal cell culture and that (2) specific antibody against this retroviral strain can be detected in MS cases. Our results suggest that, if this virus is an endogenous retrovirus, it is different from human endogenous elements already described.
D000914:Antibodies, Viral / Q000032:analysis; D000956:Antigens, Viral / Q000032:analysis / Q000276:immunology*; D015153:Blotting, Western; D002478:Cells, Cultured; D006801:Humans; D008578:Meninges / Q000382:microbiology*; D008854:Microscopy, Electron; D009103:Multiple Sclerosis / Q000382:microbiology*; D012194:RNA-Directed DNA Polymerase / Q000378:metabolism; D015531:Radioimmunoprecipitation Assay; D012190:Retroviridae / Q000276:immunology / Q000302:isolation & purification / Q000502:physiology* / Q000648:ultrastructure
D000914:Antibodies, Viral; D000956:Antigens, Viral; D012194:RNA-Directed DNA Polymerase