Pipemidic acid: its activities against various experimental infections.
Pipemidic acid, a structural relative of piromidic and nalidixic acids, exhibited substantial therapeutic activity when it was administered orally to mice bearing either widely disseminated or relatively localized infections with Staphylococcus aureus and a variety of gram-negative bacilli. The activity of pipemidic acid was always greater than that of piromidic and nalidixic acids; in infections with Pseudomonas aeruginosa and in bacilli resistant to the latter two drugs, pipemidic acid exhibited significant activity. In limited comparative studies, the activities of pipemidic acid were generally superior to the activities of cephalexin, ampicillin, and carbenicillin. Gentamicin, administered subcutaneously, was more active than pipemidic acid, given either orally or subcutaneously, against both systemic and localized infections with P. aeruginosa. The therapeutic accomplishments of pipemidic acid were attained with well-tolerated doses.
D000667:Ampicillin / Q000627:therapeutic use; D000818:Animals; D000890:Anti-Infective Agents / Q000627:therapeutic use*; D001424:Bacterial Infections / Q000188:drug therapy*; D002228:Carbenicillin / Q000627:therapeutic use; D002506:Cephalexin / Q000627:therapeutic use; D005260:Female; D005839:Gentamicins / Q000627:therapeutic use; D007674:Kidney Diseases / Q000188:drug therapy; D008171:Lung Diseases / Q000188:drug therapy; D051379:Mice; D009268:Nalidixic Acid / Q000627:therapeutic use; D009539:Nicotinic Acids / Q000627:therapeutic use*; D010879:Piperazines / Q000627:therapeutic use*; D012874:Skin Diseases, Infectious / Q000188:drug therapy; D001745:Urinary Bladder Diseases / Q000188:drug therapy; D014552:Urinary Tract Infections / Q000188:drug therapy
D000890:Anti-Infective Agents; D005839:Gentamicins; D009539:Nicotinic Acids; D010879:Piperazines; D009268:Nalidixic Acid; D000667:Ampicillin; D002228:Carbenicillin; D002506:Cephalexin