Insect blood-brain barrier: a radioisotope study of the kinetics of exchange of a liposoluble molecule (n-butanol).
About 90% of the butanol uptake by the cockroach abdominal nerve cord washed out with half-times of a few seconds, in good agreement with an electrophysiological estimate, and the temperature sensitivity suggested an activation energy of 3 Kcal mole-1. The remaining activity washed out far more slowly, with a similar time course to that observed in a previous investigation which had not detected the fast fraction. Its size was similar to the non-volatile uptake, and was considerably affected by the butanol concentration and incubation period. It apparently consisted of butanol metabolites, which could be detected by chromatography.
D000818:Animals; D001369:Axons / Q000378:metabolism*; D001665:Binding Sites; D001812:Blood-Brain Barrier; D000440:Butanols / Q000378:metabolism*; D066298:In Vitro Techniques; D007700:Kinetics; D010526:Periplaneta
D000440:Butanols