Intragastric NaHCO3 perfusion and vagal-induced ulcer formation in the rat stomach.
The effects of electrical vagal stimulation on gastric acid output and ulcer formation were studied in rats intragastrically perfused with saline or NaHCO3 solutions. Vagal stimulation produced a 100% incidence of glandular lesions and a significant increase in total acid output in saline-perfused stomachs. Antacid perfusion failed to prevent ulcer formation despite complete neutralization of the increased acid output. It is considered that vagal-induced gastric glandular lesions are not acid dependent.
D000818:Animals; D001639:Bicarbonates / Q000494:pharmacology*; D004558:Electric Stimulation; D005750:Gastric Juice / Q000378:metabolism*; D008297:Male; D051381:Rats; D013276:Stomach Ulcer / Q000209:etiology*; D014630:Vagus Nerve / Q000502:physiology*
D001639:Bicarbonates