title: In vitro demonstration of specific IgE in phthalic anhydride hypersensitivity.
abstract: Clinical sensitization to phthalic anhydride occurred in a worker who developed symptoms of rhinorrhea, lacrimination, and wheezing after exposure to this chemical. Positive skin tests, provocative bronchial challenges, and a high serum titer of specific IgE (by the radioallergosorbent test) to phthalic anhydride corroborated his clinical hypersensitivity. Bronchial provocation studies using alcoholic-saline solutions of phthalic anhydride and phthalic anhydride dust resulted in immediate airway obstruction. The successful identification of specific IgE by the radioallergosorbent test demonstrates that this can be a useful in vitro technique for corroborating sensitization to this chemical.
mesh_terms: D000328:Adult; D004342:Drug Hypersensitivity / Q000175:diagnosis*; D006801:Humans; D007073:Immunoglobulin E / Q000302:isolation & purification*; D066298:In Vitro Techniques; D008297:Male; D009784:Occupational Diseases / Q000175:diagnosis; D010795:Phthalic Acids / Q000009:adverse effects*; D011863:Radioimmunoassay; D012140:Respiratory Tract Diseases / Q000175:diagnosis / Q000209:etiology
chemical_list: D010795:Phthalic Acids; D007073:Immunoglobulin E