title: Inhibition of bull and rabbit sperm enzymes by alpha-chlorohydrin.
abstract: High concentrations of alpha-chlorohydrin were found to inhibit hyaluronidase, beta-glucuronidase, and aryl sulphatases in bull and rabbit spermatozoa, but not acrosin and neuraminidase. Preincubation of the enzyme and alpha-chlorohydrin was essential to achieve the maximum inhibition which was irreversible.
mesh_terms: D000176:Acrosin / Q000037:antagonists & inhibitors; D000818:Animals; D001192:Arylsulfatases / Q000037:antagonists & inhibitors; D002728:Chlorohydrins / Q000494:pharmacology*; D005966:Glucuronidase / Q000037:antagonists & inhibitors; D006821:Hyaluronoglucosaminidase / Q000037:antagonists & inhibitors; D008297:Male; D009439:Neuraminidase / Q000037:antagonists & inhibitors; D011817:Rabbits; D013094:Spermatozoa / Q000187:drug effects / Q000201:enzymology*; D000517:alpha-Chlorohydrin / Q000494:pharmacology*
chemical_list: D002728:Chlorohydrins; D000517:alpha-Chlorohydrin; D001192:Arylsulfatases; D009439:Neuraminidase; D005966:Glucuronidase; D006821:Hyaluronoglucosaminidase; D000176:Acrosin