Lactate and pyruvate as fetal metabolic substrates.
Lactate and pyruvate concentration differences across the fetal umbilical circulation and the maternal uterine circulation were measured in a chronic sheep preparation. Significant gains in lactate in both the fetal and maternal circulations were observed. The lactate taken up by the fetus would account for 32% of fetal oxygen consumption if oxidized. There was no significant change in pyruvate concentration across the fetal umbilical circulation; however, pyruvate was gained by maternal uterine blood.
D000818:Animals; D050260:Carbohydrate Metabolism; D005260:Female; D005312:Fetal Blood / Q000032:analysis; D005333:Fetus / Q000378:metabolism*; D007773:Lactates / Q000097:blood / Q000378:metabolism*; D008431:Maternal-Fetal Exchange; D008954:Models, Biological; D010101:Oxygen Consumption; D011247:Pregnancy; D011773:Pyruvates / Q000097:blood / Q000378:metabolism*; D012756:Sheep
D007773:Lactates; D011773:Pyruvates