title: Metabolic formation and synthesis of 1-(3-chlorophenyl)-2(4-hydroxyphenyl)-1-methyl-2(2 pyridine)ethanol. A potential hypocholesteremic agent.
abstract: 1-(3-Chlorophenyl)-2-(4-hydroxphenyl)-1-methyl-2(2-pyridine)ethanol (8a) has been synthesized and found to be the major urinary metabolite following intraperitoneal administration of 1-(3-chlorophenyl)-1-methyl-2-phenyl-2-(2-pyridine)ethanol (1) to rats. This metabolite has a hypocholesteremic effect in rats similar to that of the parent drug.
mesh_terms: D000818:Animals; D000924:Anticholesteremic Agents / Q000138:chemical synthesis*; D002784:Cholesterol / Q000097:blood; D008297:Male; D011725:Pyridines / Q000138:chemical synthesis* / Q000494:pharmacology / Q000652:urine; D051381:Rats; D013997:Time Factors
chemical_list: D000924:Anticholesteremic Agents; D011725:Pyridines; D002784:Cholesterol