Effect of 6-hydroxydopamine on diet-induced hyperlipidemia and atherosclerosis in the rat.
The effect of 6-hydroxydopamine (6-OH-dopamine) and of a cholesterol rich diet on the plasma and aortic cholesterol of female rats were studied. Both the diet and the 6-OH-dopamine produced an important increase in plasmatic and aortic cholesterol. A synergistic effect of these two treatments was observed on the plasma but not on the aortic cholesterol. The mechanism by which 6-OH-dopamine produces hypercholesterolemia and a increase in aortic cholesterol remains to be explained.
D000818:Animals; D001011:Aorta / Q000378:metabolism; D001161:Arteriosclerosis / Q000139:chemically induced*; D001835:Body Weight / Q000187:drug effects; D002784:Cholesterol / Q000097:blood / Q000378:metabolism; D004036:Diet, Atherogenic; D005260:Female; D006892:Hydroxydopamines / Q000494:pharmacology*; D006949:Hyperlipidemias / Q000139:chemically induced*; D051381:Rats; D013562:Sympathectomy
D006892:Hydroxydopamines; D002784:Cholesterol