title: [Clinico-pathophysiologic aspects of a study of the hereditary predisposition of children and adolescents to epilepsy].
abstract: In a clinical, genealogical, biochemical, immunological and EEG study of children and adolescents with epilepsy and their closest relatives, it was established that the general activity of lactate dehydrogenase and the % of LDH in the blood sera of probands is higher than in normals. These changes were more expressed in the blood sera of probands and sibs, rather than in parents. The coefficient of inheritance according to both biochemical indices for probands and their relatives was approximately 80-85%. There were no differences in relation to the biological indices between epilepsy of an unknown nature and a symptomatical genesis.
mesh_terms: D001323:Autoantibodies; D001921:Brain / Q000276:immunology; D002648:Child; D004569:Electroencephalography; D004827:Epilepsy / Q000097:blood / Q000235:genetics* / Q000276:immunology; D005260:Female; D006801:Humans; D007527:Isoenzymes; D007770:L-Lactate Dehydrogenase / Q000097:blood*; D008297:Male
chemical_list: D001323:Autoantibodies; D007527:Isoenzymes; D007770:L-Lactate Dehydrogenase
vernacular_title: Kliniko-patofiziologicheskie aspekty izucheniia nasledstvennogo oredraspolozheniia képilepsii u deteĭ i podrostkov