The effect of detergent treatment of the gastric mucosa on drug transport.
The effect of detergent treatment of the canine gastric mucosa on transport of drugs from blood to gastric juice was studied using a chamber technique, in vivo. Detergent treatment was found to increase antipyrine and aminopyrine transport. Facilitation of drug transport was associated with disruption of the gastric mucosal barrier and an increase of aminopyrine clearance.
D000632:Aminopyrine / Q000378:metabolism*; D000818:Animals; D000983:Antipyrine / Q000378:metabolism*; D001692:Biological Transport / Q000187:drug effects; D004058:Diffusion; D004285:Dogs; D005753:Gastric Mucosa / Q000187:drug effects* / Q000378:metabolism / Q000502:physiology; D008564:Membrane Potentials; D008657:Metabolic Clearance Rate; D011522:Protons; D012964:Sodium / Q000378:metabolism; D012967:Sodium Dodecyl Sulfate / Q000494:pharmacology*
D011522:Protons; D000632:Aminopyrine; D012967:Sodium Dodecyl Sulfate; D012964:Sodium; D000983:Antipyrine