New method for detecting and quantitating pharmacokinetic drug-drug interactions applied to ethanol-propranolol.
A novel method for detecting and quantitating pharmacokinetic drug-drug interactions is described. The method involves perturbation of an existing steady-state whole blood (or plasma) concentration of one drug by the other drug. The method would allow differentiation of "pharmacokinetic" drug interactions from "pharmacologic" interactions. It is shown that a bolus intravenous injection of propranolol reduced a steady-state arterial blood concentration of ethyl alcohol by 26% in the cat.
D000079:Acetaldehyde / Q000097:blood; D000818:Animals; D002415:Cats; D000431:Ethanol / Q000097:blood / Q000378:metabolism*; D007700:Kinetics; D008722:Methods; D011433:Propranolol / Q000494:pharmacology*
D000431:Ethanol; D011433:Propranolol; D000079:Acetaldehyde