Effect of chlorothiazide and furosemide diuresis on in vivo growth of Staphylococcus aureus in kidneys of mice.
In mice subcutaneous administration of the diuretics chlorothiazide or furosemide resulted in a prompt diuresis characterized by production of dilute urine within 30 min and lasting for 6 hr. In vivo proliferation or clearance of Staphylococcus aureus from the kidneys was only temporarily impaired during the time of maximum diuresis. When treatment was delayed until after phagocytosis was initiated, there was no effect on clearance. Clinically it would appear that bacterial proliferations in the renal parenchyma would not be promoted as a consequence of diuretic treatment.
D000818:Animals; D002740:Chlorothiazide / Q000008:administration & dosage / Q000494:pharmacology*; D004231:Diuresis; D005665:Furosemide / Q000008:administration & dosage / Q000494:pharmacology*; D007279:Injections, Subcutaneous; D007668:Kidney / Q000382:microbiology*; D008297:Male; D051379:Mice; D013211:Staphylococcus aureus / Q000187:drug effects / Q000254:growth & development*
D002740:Chlorothiazide; D005665:Furosemide