title: Objective evaluation of the quality of palliation in patients with oesophageal cancer comparing surgery, radiotherapy and intubation.
abstract: The objective of this study was to prospectively evaluate the quality of palliation of 103 patients presenting to a joint oesophageal cancer clinic while recording the outcome in terms of treatment, morbidity, mortality and long-term survival. Twenty-five patients underwent surgical resection (S), 22 radical radiotherapy (RR), 30 palliative radiotherapy (PR), 13 intubation (I) and 13 had no treatment (NT). The quality of palliation was quantified by plotting a score out of 100 on a graph at each visit for Karnofsky performance, severity of pain and swallowing ability, then calculating the area under each curve created using an algorithm, Simpson's discrete approximation. Efficiency of palliation was estimated by comparing the area calculated to the maximum that could be achieved during the time frame being studied. The incidence of stricture (benign and malignant) was 16% after surgery and 50% after radical radiotherapy. Treatment mortality was as follows: RR, 0; S, 1 (4%); PR, 3 (7%); and I, 0. The median survival was 26 months after surgery and 16 months after radical radiotherapy. It was 6 months for palliative radiotherapy, 4 months for intubation and 4 months for no treatment. The difference in swallowing was the only statistical difference in the quality of palliation of patients having surgery and radical radiotherapy, there being no differences in patients having palliative measures.
mesh_terms: D000203:Activities of Daily Living; D000368:Aged; D002985:Clinical Protocols / Q000592:standards; D003680:Deglutition Disorders / Q000175:diagnosis / Q000453:epidemiology / Q000209:etiology; D004938:Esophageal Neoplasms / Q000401:mortality / Q000503:physiopathology / Q000628:therapy*; D016629:Esophagectomy / Q000009:adverse effects / Q000592:standards*; D005260:Female; D006801:Humans; D015994:Incidence; D007441:Intubation, Gastrointestinal / Q000009:adverse effects / Q000592:standards*; D008297:Male; D009017:Morbidity; D009364:Neoplasm Recurrence, Local; D009367:Neoplasm Staging; D009517:New South Wales / Q000453:epidemiology; D017063:Outcome Assessment, Health Care; D010146:Pain / Q000175:diagnosis / Q000453:epidemiology / Q000209:etiology; D010166:Palliative Care / Q000379:methods / Q000592:standards*; D011183:Postoperative Complications / Q000453:epidemiology / Q000209:etiology; D011446:Prospective Studies; D011787:Quality of Health Care; D011788:Quality of Life; D011878:Radiotherapy / Q000009:adverse effects / Q000592:standards*; D012720:Severity of Illness Index; D015996:Survival Rate; D016896:Treatment Outcome