The effect of arterial oxygen tension on antipyrine half-time in plasma.
Hospital patients with depressed arterial oxygen tensions (PaO2) from pulmonary disease were given antipyrine orally or intravenously. The half-time (t1/2) of disappearance from plasma was measured. Other patients with normal PaO2 measurements were treated similarly. Patients whose PaO2 was 55 or below had longer t1/2 times than those of patients with a PaO2 above 55. This observation parallels that made previously in rats.
D000983:Antipyrine / Q000097:blood*; D006207:Half-Life; D006801:Humans; D008171:Lung Diseases / Q000378:metabolism; D010100:Oxygen / Q000097:blood*; D013997:Time Factors
D010100:Oxygen; D000983:Antipyrine