Enhanced erythropoietin and prostaglandin E production in the dog following renal artery constriction.
Renal artery constriction (RAC) to 30% of normal flow for 12 hr in the unilaterally nephrectomized dog produced a marked increase in both erythropoietin titers and prostaglandin E (PGE) levels in the blood. In dogs pretreated prior to RAC with indomethacin, a potent inhibitor of prostaglandin synthetase, there was no significant increase in either PGE or erythropoietin levels as compared to zero-time control values. These data suggested an involvement of renal PGE in the generation of erythropoietin following RAC.
D000818:Animals; D001794:Blood Pressure; D003250:Constriction; D004285:Dogs; D005260:Female; D007213:Indomethacin / Q000494:pharmacology; D007511:Ischemia / Q000378:metabolism* / Q000503:physiopathology; D007668:Kidney / Q000098:blood supply* / Q000187:drug effects / Q000378:metabolism; D011458:Prostaglandins E / Q000096:biosynthesis* / Q000097:blood; D012039:Regional Blood Flow; D012077:Renal Artery
D011458:Prostaglandins E; D007213:Indomethacin