Tissue reaction to methyl methacrylate monomer. A comparative study in the rabbit's ear on the toxicity of methyl methacrylate monomer of varying composition.
The aim of the present investigation was to evaluate if a bone cement monomer with a high concentration of accelerator (N,N-dimethyl-p-toluidine) is more toxic than a methyl methacrylate monomer, free from accelerator. 1) No difference in the acute local toxicity between CMW, Simplex-P and pure methyl methacrylate monomer was seen. 2) By gas chromatography. N,N-dimethyl-p-toluidine was shown to be water soluble to a small extent. Any bone cement monomer in current use can be fully dissolved in saline to a concentration of about 1 per cent.
D000818:Animals; D001843:Bone Cements / Q000633:toxicity*; D004423:Ear / Q000098:blood supply / Q000187:drug effects*; D005260:Female; D008768:Methylmethacrylates / Q000633:toxicity*; D008833:Microcirculation / Q000187:drug effects; D011817:Rabbits; D012995:Solubility; D014052:Toluidines / Q000633:toxicity
D001843:Bone Cements; D008768:Methylmethacrylates; D014052:Toluidines