Preferential expression of anti-azobenzenearsonate antibodies of heterozygous a1a3 rabbits in the a1 allotype.
The preferential expression of anti-As antibodies in the allotype a1 of heterozygous a1a3 rabbits immunized with As-TMA-BSA has been investigated by means of quantitative methods. The average content of the anti-As antibodies in a1 and a3 allotypes was 84 and 11%, respectively; the analogous values for anti-TMA antibodies were 41 and 56%, and for anti-BSA antibodies they were 54 and 41%. The molar anti-As/anti-TMA ratios in the heterozygous a1a1 rabbits sensitized with As-TMA-BSA. The very low yields of anti-As-antibodies of allotype a3 cannot be caused by a lack of genes for the production of anti-As antibodies of allotype a3 because a3a3 homozygotes produce considerable amounts of anti-As antibody of allotpye a3. Competition between lymphoid cells having anti-As receptors of different allotype and different affinity for the antigenic p-azobenzenearsonate determinant is discussed as a possible cause for the preferential expression in the a1 allotype.
D000818:Animals; D000937:Antigen-Antibody Reactions; D001391:Azo Compounds / Q000276:immunology*; D006579:Heterozygote; D007106:Immune Sera / Q000494:pharmacology; D007126:Immunoglobulin Allotypes; D000644:Quaternary Ammonium Compounds / Q000276:immunology; D011817:Rabbits; D012710:Serum Albumin, Bovine / Q000276:immunology; D010132:p-Azobenzenearsonate / Q000276:immunology*
D001391:Azo Compounds; D007106:Immune Sera; D007126:Immunoglobulin Allotypes; D000644:Quaternary Ammonium Compounds; D012710:Serum Albumin, Bovine; D010132:p-Azobenzenearsonate