title: In vitro displacement of vasoactive mediators from plasma proteins: a possible mechanism for pseudo-allergic reactions to neuromuscular blocking drugs.
abstract: We have studied the release of prostaglandin F2 alpha (PGF2 alpha) and histamine from serum proteins by neuromuscular blocking drugs using equilibrium dialysis, with tracer quantities of radio-labelled mediators as probes. Small concentrations (0.05-0.25 mmol litre-1) of competitive neuromuscular blocking drugs displaced 16-67% of bound histamine. Greater concentrations of suxamethonium (2 mmol litre-1) were required for histamine displacement (19%). There was a significant release of PGF2 alpha by atracurium 1 mmol litre-1 and pancuronium 0.69 mmol litre-1. These findings suggest an alternative mechanism of histamine release by neuromuscular blocking drugs which may be relevant to adverse reactions during use.
mesh_terms: D001798:Blood Proteins / Q000187:drug effects*; D015237:Dinoprost / Q000097:blood*; D004305:Dose-Response Relationship, Drug; D006632:Histamine / Q000097:blood*; D006636:Histamine Release / Q000187:drug effects*; D006801:Humans; D066298:In Vitro Techniques; D009466:Neuromuscular Blocking Agents / Q000009:adverse effects*
chemical_list: D001798:Blood Proteins; D009466:Neuromuscular Blocking Agents; D006632:Histamine; D015237:Dinoprost