Onset of enzyme induction with pregnenolone-16alpha-carbonitrile in male and female rats.
Male and female rats treated with a single 20-mg/kg ip dose of pregnenolone-16alpha-carbonitrile (PCN) produced parallel increases in hepatic cytochrome P-450 and aniline hydroxylase activity. However, the onset of increase in aniline hydroxylase activity and cytochrome P-450 content was slower in male than female animals. The maximal levels achieved in male rats were 89% of the values observed in the female animals. Furthermore, the hepatic aniline hydroxylase activity and P-450 content declined more rapidly in male than in female rats.
D000815:Aniline Hydroxylase / Q000378:metabolism; D000818:Animals; D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism; D004790:Enzyme Induction / Q000187:drug effects; D005260:Female; D008099:Liver / Q000187:drug effects / Q000201:enzymology*; D008297:Male; D006899:Mixed Function Oxygenases / Q000378:metabolism*; D010088:Oxidoreductases / Q000378:metabolism*; D011285:Pregnenolone Carbonitrile / Q000494:pharmacology*; D011506:Proteins / Q000378:metabolism; D051381:Rats; D012737:Sex Factors
D011506:Proteins; D011285:Pregnenolone Carbonitrile; D003577:Cytochrome P-450 Enzyme System; D006899:Mixed Function Oxygenases; D010088:Oxidoreductases; D000815:Aniline Hydroxylase