title: Electroencephalographic changes following intraamniotic prostaglandin F2 alpha administration for therapeutic abortion.
abstract: Electroencephalograms were obtained on 43 patients undergoing therapeutic second trimester abortion using intraamniotic prostaglandin F2alpha. Recordings were made before and 4 hours after prostaglandin administration, as well as 4 hours after the abortion. At 4 hours after prostaglandin administration, 30% of the women had abnormal tracings, while 50% of the women had abnormal recordings 4 hours postabortion. Although the changes consisted primarily of mild generalized or lateralized slowing, 4 patients developed paroxysmal activity not initially present. This finding would seem to suggest a potential relationship between PGF2alpha administration and clinical seizures.
mesh_terms: D000032:Abortion, Therapeutic; D000650:Amnion; D004569:Electroencephalography; D004827:Epilepsy / Q000139:chemically induced; D005260:Female; D006801:Humans; D007267:Injections; D011247:Pregnancy; D011446:Prospective Studies; D011460:Prostaglandins F / Q000009:adverse effects* / Q000627:therapeutic use; D012640:Seizures / Q000139:chemically induced
chemical_list: D011460:Prostaglandins F