Fluorocarbon aerosol propellants X: pharmacokinetics of dichlorotetrafluoroethane in dogs.
An intravenous dosage form of dichlorotetrafluoroethane, a common fluorocarbon aerosol propellant, was formulated in polyethylene glycol 400 for single dosing to unanesthetized dogs. A  three-compartment open model was proposed for the disposition of this compound in dogs, with average half-lives of 1.3, 9.6, and 50.8 min for the three disposition phases. An analysis of tissue compartment distribution following a single dose showed that it took about 2 hr to achieve pseudo-distribution equilibration, following which more than 90% of the propellant remaining in the body was retained in the tissue compartments. Pulmonary clearance and volumes of distribution were calculated considering the first-pass effect through the lungs. The volume of distribution was approximately 10 times the body weight in terms of blood concentration, and about 84% of the propellant was cleared from the blood passing through the lungs in each cycle.
D000335:Aerosol Propellants / Q000008:administration & dosage / Q000097:blood / Q000378:metabolism*; D000336:Aerosols / Q000378:metabolism*; D000818:Animals; D004285:Dogs; D006846:Hydrocarbons, Halogenated / Q000008:administration & dosage / Q000097:blood / Q000378:metabolism*; D007275:Injections, Intravenous; D007700:Kinetics; D008168:Lung / Q000378:metabolism; D008297:Male; D008954:Models, Biological
D000335:Aerosol Propellants; D000336:Aerosols; D006846:Hydrocarbons, Halogenated