The regulatory control of beta-receptor dependent adenylate cyclase.
The characteristics of the beta-receptor in turkey erythrocyte adenylate cyclase were studied using both kinetics of enzyme activation and direct binding measurement of the beta-agonists and antagonists to the beta-receptor. The regulatory ligands Gpp(NH)p and Ca2+ do not have any direct effect on the beta-receptor, but modulate the enzyme activity through the interaction with specific regulatory sites.
D000262:Adenylyl Cyclases / Q000097:blood*; D000818:Animals; D001665:Binding Sites; D001667:Binding, Competitive; D001798:Blood Proteins / Q000378:metabolism; D002118:Calcium / Q000494:pharmacology; D002462:Cell Membrane / Q000187:drug effects / Q000378:metabolism; D004789:Enzyme Activation / Q000187:drug effects; D004837:Epinephrine / Q000378:metabolism / Q000494:pharmacology; D004912:Erythrocytes / Q000378:metabolism*; D006150:Guanine Nucleotides / Q000494:pharmacology; D006160:Guanosine Triphosphate / Q000494:pharmacology; D007700:Kinetics; D008274:Magnesium / Q000494:pharmacology; D008433:Mathematics; D011433:Propranolol / Q000378:metabolism / Q000494:pharmacology; D011485:Protein Binding; D011941:Receptors, Adrenergic; D014422:Turkeys
D001798:Blood Proteins; D006150:Guanine Nucleotides; D011941:Receptors, Adrenergic; D006160:Guanosine Triphosphate; D011433:Propranolol; D000262:Adenylyl Cyclases; D008274:Magnesium; D002118:Calcium; D004837:Epinephrine