title: The effect of various vasoactive compounds upon the uterine vascular bed.
abstract: The effects of various vasodilators on the uterine vascular bed were investigated in nonpregnant, oophorectomized sheep with chronically implanted flow probes and catheters inserted into branches of the uterine arteries. A 1 mug dose of estradiol-17beta (0.224 muM) produces a maximum uterine blood flow response after intra-arterial injection. Adenosine (24 muM) and bradykinin (0.02 muM) were observed to increase blood flow to levels achieved by 1 mug of estradiol-17beta. Acetylcholine, isoproterenol, and histamine were less potent in their vasodilator activity. Atropine, propanolol, and diphenhydramine did not inhibit the increase of uterine blood flow induced by estrogens.
mesh_terms: D000109:Acetylcholine / Q000494:pharmacology; D000227:Adenine Nucleotides / Q000494:pharmacology; D000241:Adenosine / Q000096:biosynthesis / Q000494:pharmacology; D000818:Animals; D001158:Arteries / Q000187:drug effects; D001920:Bradykinin / Q000096:biosynthesis / Q000494:pharmacology; D004958:Estradiol / Q000494:pharmacology; D005260:Female; D006632:Histamine / Q000494:pharmacology; D007545:Isoproterenol / Q000494:pharmacology; D009130:Muscle, Smooth / Q000187:drug effects; D011955:Receptors, Drug; D012039:Regional Blood Flow / Q000187:drug effects; D012756:Sheep; D014599:Uterus / Q000098:blood supply*; D014665:Vasodilator Agents / Q000494:pharmacology*
chemical_list: D000227:Adenine Nucleotides; D011955:Receptors, Drug; D014665:Vasodilator Agents; D004958:Estradiol; D006632:Histamine; D000241:Adenosine; D007545:Isoproterenol; D000109:Acetylcholine; D001920:Bradykinin