[Experimental vestibulopathy produced as a result of formation of a generator of pathologically enhanced excitation in the vestibular nuclei (phenomenon of a determinative dispatch station)].
A possibility of formation of a generator of pathologically enhanced excitation in the system of the vestibular nuclei of the medulla oblongata by disturbance of their inhibitory processes (resulting in development of contralateral rotatory motions in animals) was shown. Experiments with electrical stimulation of the lateral vestibular nucleus and its coagulation showed the system of the vestibular neurons organizing the synchronous message by the vestibulo-spinal pathways to underlie the generator of the pathologically enhanced excitation. It was concluded that the generator of the pathologically enhanced excitation formed in the lateral vestibular nucleus as a result of disturbed inhibition underlied the hyperactive determinative dispatch station causing the syndrome of vestibulopathy
D000818:Animals; D001927:Brain Diseases / Q000139:chemically induced; D004195:Disease Models, Animal; D008297:Male; D009069:Movement Disorders / Q000139:chemically induced*; D051381:Rats; D013744:Tetanus Toxin; D014726:Vestibular Nuclei
D013744:Tetanus Toxin
Eksperimental'naia vestibulopatiia, poluchennaia v rezul'tate obrazovaniia generatora patologicheski usilennogo vozbuzhdeniia v vestibuliarnykh iadrakh (k fenomenu determiniruiushcheĭ stantsii otpravleniia)