title: The effect of steroid hormones on motility and selective migration of X- and Y-bearing human spermatozoa.
abstract: Motility and selective migration of X- and Y-bearing human spermatozoa were studied in the presence of physiologic levels of sex steroid hormones (17beta-estradiol; estriol, 0.5 ng/ml; testosterone; progesterone; lynestrenol; and norgestrel, 5 ng/ml) and 200-fold higher concentrations. Estrogens and, to a smaller extent, testosterone accelerated spermatozoal migration, while gestagens had an inhibitory effect. 17beta-Estradiol was most effective in stimulating the motility of human spermatozoa, while norgestrel caused the strongest inhibition of forward movement. Migration of X- and Y-bearing spermatozoa was most significantly altered after longer distances of migration, shown by an increase in the percentage of Y-bearing spermatozoa from 43.7% to 63.3% at a distance of 90 mm. However, prolongation of migration time to 36 hours caused a reduction in the percentage of Y-bearing spermatozoa at the 90-mm distance, from 63.3% to 46%. Specific differential effects of sex steroid hormones on the pattern of selective migration and the distribution of X- and Y-bearing spermatozoa were not observed.
mesh_terms: D004958:Estradiol / Q000494:pharmacology; D004964:Estriol / Q000494:pharmacology; D012739:Gonadal Steroid Hormones / Q000494:pharmacology*; D006801:Humans; D008234:Lynestrenol / Q000494:pharmacology; D008297:Male; D009644:Norgestrel / Q000494:pharmacology; D011374:Progesterone / Q000494:pharmacology; D012730:Sex Chromosomes / Q000502:physiology; D013081:Sperm Motility / Q000187:drug effects*; D013094:Spermatozoa / Q000187:drug effects*; D013739:Testosterone / Q000494:pharmacology
chemical_list: D012739:Gonadal Steroid Hormones; D009644:Norgestrel; D013739:Testosterone; D011374:Progesterone; D004958:Estradiol; D004964:Estriol; D008234:Lynestrenol