Inhibition of human chorionic gonadotrophin-induced hypertrophy of the ovaries and uterus in immature mice by some pineal indoles, 6-hydroxymelatonin and arginine vasotocin.
Administration of the indoles 5-methoxytryptophol, 6-hydroxymelatonin, melatonin, N-acetylserotonin or 5-methoxyindole-3-acetic acid (six 100-mug injections given at intervals of 12 h) inhibited both the absolute and relative ovarian and uterine weights of immature female mice pre-treated with HCG. Administration of 5-hydroxytryptophol or 5-methoxytryptamine at the same dosage inhibited ovarian but not uterine hypertrophy in mice pre-treated with HCG.
D000818:Animals; D006063:Chorionic Gonadotropin; D003864:Depression, Chemical; D005260:Female; D007211:Indoles / Q000494:pharmacology*; D008550:Melatonin / Q000031:analogs & derivatives / Q000494:pharmacology*; D051379:Mice; D009929:Organ Size / Q000187:drug effects; D010053:Ovary / Q000187:drug effects*; D012701:Serotonin / Q000031:analogs & derivatives / Q000494:pharmacology; D014599:Uterus / Q000187:drug effects*; D014668:Vasotocin / Q000494:pharmacology*
D006063:Chorionic Gonadotropin; D007211:Indoles; D012701:Serotonin; C002465:methoxytryptophol; D008550:Melatonin; C012365:6-hydroxymelatonin; D014668:Vasotocin