title: [Pathogenetic therapy of spontaneous corneal perforation after extracapsular cataract extraction].
abstract: The author presents a case with spontaneous perforation of the cornea after extracapsular cataract extraction in a female patient with rheumatoid arthritis. Systemic disorganization of the connective tissue and elevated collagenase activity essentially contribute to the pathogenesis of corneal perforation. Therefore, besides antibacterial drugs, collagenase inhibitors, 3% aqueous solution of cysteine, antimeasles gamma-globulin, and a regeneration stimulant, 5% ascorbic acid aqueous solution, were used in the treatment. The pathogenetic therapy was conducive to early healing of the corneal defect and helped save the eye and preserve its good function (0.8 s + 10.0 diopters).
mesh_terms: D001172:Arthritis, Rheumatoid / Q000150:complications* / Q000378:metabolism; D001205:Ascorbic Acid / Q000008:administration & dosage; D002386:Cataract / Q000150:complications* / Q000378:metabolism; D002387:Cataract Extraction / Q000009:adverse effects*; D003094:Collagen / Q000378:metabolism; D003131:Combined Modality Therapy; D003315:Cornea / Q000378:metabolism; D003316:Corneal Diseases / Q000209:etiology* / Q000378:metabolism / Q000628:therapy; D003545:Cysteine / Q000008:administration & dosage; D005260:Female; D006801:Humans; D008875:Middle Aged; D012422:Rupture, Spontaneous; D014945:Wound Healing; D005719:gamma-Globulins / Q000008:administration & dosage
chemical_list: D005719:gamma-Globulins; D003094:Collagen; D003545:Cysteine; D001205:Ascorbic Acid
vernacular_title: Patogeneticheskaia terapiia spontannoĭ perforatsii rogovitsy posle ékstrakapsuliarnoĭ ékstraktsii katarakty.