[Epithelial proliferations in organ cultures of mouse lung treated with urethane and 3,4-benzopyrene].
The authors carried out some series of experiments under the conditions of organ cultures of lungs of mice, treated with urethane and 3,4-benzpirene. They succeeded lung culturinf up to 14-th and 21-th day. Growths of bronchial and bronciolar epithelium manifested at various degree were obtained in the lung extracts from mice, treated with urethane and 3,4-benzpirene. The most manifested proliferation was observed in extracts, treated with urethane at a dose of 10 mg/ml and 3,4-benzpirene -- 64 gamma/ml.
D000818:Animals; D001580:Benzopyrenes / Q000494:pharmacology* / Q000633:toxicity; D004305:Dose-Response Relationship, Drug; D004847:Epithelial Cells; D004848:Epithelium / Q000187:drug effects; D008168:Lung / Q000166:cytology / Q000187:drug effects*; D051379:Mice; D008815:Mice, Inbred Strains; D009924:Organ Culture Techniques; D013997:Time Factors; D014520:Urethane / Q000494:pharmacology* / Q000633:toxicity
D001580:Benzopyrenes; D014520:Urethane
Epitelni proliferati v organni kulturi ot beli drobove na mishki, tretirani s uretan i 3,4-benzpiren