Fluorometric assay of verapamil in biological fluids and tissues.
Verapamil concentrations in blood, urinee, or tissue homogenates may be measured fluorometrically in the 0.1-10-mug/ml range after extraction into heptane and back-extraction into acid; recovery rates are above 87%. The drug apparently is eliminated rapidly in guinea pigs, with a plasma half-life of 45 min.
D000818:Animals; D006168:Guinea Pigs; D006207:Half-Life; D008099:Liver / Q000378:metabolism; D008722:Methods; D009206:Myocardium / Q000378:metabolism; D013050:Spectrometry, Fluorescence; D013997:Time Factors; D014700:Verapamil / Q000032:analysis* / Q000378:metabolism
D014700:Verapamil