NMR analysis of pharmaceuticals XIV: determination of amyl nitrite in its inhalant dosage form.
An NMR procedure is described for the analysis of amyl nitrite as a drug entity and in inhalant dosage forms. The choices of solvent (carbon tetrachloride) and internal standards (biphenyl or benzyl benzoate) were made with respect to stability problems and the presence of stabilizers in the formulation. The method is precise, with a standard deviation of +/-0.5. The NMR results of synthetic solutions and commercial preparations were compared with those obtained by a published relative NMR procedure and a compendial titrimetric method. The results were generally satisfactory.
D000680:Amyl Nitrite / Q000032:analysis*; D004355:Drug Stability; D009682:Magnetic Resonance Spectroscopy
D000680:Amyl Nitrite