A critical examination of the value of combined determinations of lecithin:cholesterol acyltransferase and lipoprotein-X in the differential diagnosis of liver disease.
The suggestion that combined determinations of lecithin: cholesterol acyltransferase activity and lipoprotein-X can be used to distinguish between patients with intrahepatic cholestasis and extrahepatic biliary obstruction has been studied. Of 21 patients who were lipoprotein-X positive and in whom an unequivocal diagnosis was made, 11 had intrahepatic cholestasis and 10 extrahepatic obstruction. The range of plasma lecithin:cholesterol acyltransferase activity was similar in the two groups and did not enable distinction to be made between them.
D000217:Acyltransferases / Q000097:blood*; D001660:Biliary Tract Diseases / Q000097:blood / Q000175:diagnosis / Q000201:enzymology; D002779:Cholestasis / Q000097:blood / Q000175:diagnosis / Q000201:enzymology; D003937:Diagnosis, Differential; D006801:Humans; D008074:Lipoproteins / Q000097:blood*; D008107:Liver Diseases / Q000175:diagnosis*; D007862:Phosphatidylcholine-Sterol O-Acyltransferase / Q000097:blood*
D008074:Lipoproteins; D000217:Acyltransferases; D007862:Phosphatidylcholine-Sterol O-Acyltransferase