The effect of vitamin E on platelet aggregation.
Platelet aggregation studies were performed in five men with coronary artery disease and angina pectoris and five men with nonspecific chest pain before and after receiving 1,000 I.U. of alpha-tocopherol acetate orally per day for 8 days. There was no significant difference in the platelet aggregation response to three concentrations of ADP and two concentrations of epinephrine between the pre- and post-vitamin E periods among the 10 patients. If tocopherol acetate (vitamin E) has any beneficial effect on the prevention of thromboemolism or in the treatment of angina pectoris and peripheral vascular disease, it is not via inhibition of platelet aggregation.
D000244:Adenosine Diphosphate / Q000494:pharmacology; D000328:Adult; D000787:Angina Pectoris / Q000097:blood; D004837:Epinephrine / Q000494:pharmacology; D006801:Humans; D008297:Male; D008875:Middle Aged; D010974:Platelet Aggregation / Q000187:drug effects*; D013923:Thromboembolism / Q000517:prevention & control; D014810:Vitamin E / Q000494:pharmacology* / Q000627:therapeutic use
D014810:Vitamin E; D000244:Adenosine Diphosphate; D004837:Epinephrine