[The influence of several surface-active substances on neuromuscular transmission of excitation].
Microelectrode method was applied to the study of the influence of sodium bile salts (BS), saponin and between-80 on the end-plate potentials (EPP) of m. sartorius of Rana ridibunda. Bile salts in a concentration of 10(-5) g/ml did not change these potentials significantly. With increase of the BS concentration up to 10(-4) g/ml the amplitude of EPP increased 1.5- 3 times. The action of these substances in a concentration up to 10(-3) g/ml caused similar, but more rapid, increase in the EPP amplitude, and then the amplitude decreased. Saponin and tween-80 were less efffective in their action on EPP, but evoked muscle contraction. It is suggested that an increase in the EPP amplitude as a result of the action of the mentioned agents was chiefly connected with stimulation of the acetylcholine release by the nerve terminals.
D000109:Acetylcholine / Q000378:metabolism; D000818:Animals; D001647:Bile Acids and Salts / Q000494:pharmacology; D008564:Membrane Potentials / Q000187:drug effects*; D009119:Muscle Contraction / Q000187:drug effects; D009469:Neuromuscular Junction / Q000187:drug effects*; D011136:Polysorbates / Q000494:pharmacology; D011898:Ranidae; D012503:Saponins / Q000494:pharmacology; D013268:Stimulation, Chemical; D013501:Surface-Active Agents / Q000494:pharmacology*
D001647:Bile Acids and Salts; D011136:Polysorbates; D012503:Saponins; D013501:Surface-Active Agents; D000109:Acetylcholine
Vliianie nekotorykh poverkhnostno-aktivnykh veshchestv na nervno-myshechnuiu peredachu vozbuzhdeniia