title: Patient tolerance of long-term diuretic/potassium supplement therapy.
abstract: Forty patients with congestive heart failure or hypertensive heart disease were given long-term maintenance treatment with a combined bumetanide/slow-release potassium supplement preparation ('Burinex K'). Stabilised doses ranged from 0.5 mg to 2 mg bumetanide with from 7.7 mmol to 30.8 mmol potassium. Patients took doses either at 9 a.m. or at 5 p.m. daily during a series of alternate 2 to 4-weekly treatment periods. Analysis of patient preference for morning or evening diuresis showed that the majority (72.5%), including all 18 patients who went out to work, preferred the evening regimen. Bumetanide proved to be a highly effective diuretic, irrespective of time of administration. Evening diuresis was associated with a statistically significant increase in the 24-hour excretion of sodium. Serial laboratory analyses showed no clinically significant changes in serum potassium or other parameters examined an in contrast to other diuretics bumetanide produced no significant hyperuricaemic effects.
mesh_terms: D000328:Adult; D000368:Aged; D002034:Bumetanide / Q000008:administration & dosage* / Q000627:therapeutic use; D004232:Diuretics / Q000008:administration & dosage*; D004338:Drug Combinations; D005260:Female; D006331:Heart Diseases / Q000188:drug therapy*; D006333:Heart Failure / Q000188:drug therapy*; D006801:Humans; D006973:Hypertension / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged; D011188:Potassium / Q000008:administration & dosage* / Q000627:therapeutic use; D013997:Time Factors
chemical_list: D004232:Diuretics; D004338:Drug Combinations; D002034:Bumetanide; D011188:Potassium