title: A search for antitumor compounds. XI. Biologic studies. Antitumor properties of 19 new 9-aminoacridine and 1-or 3-nitro-9-aminoacridine derivatives.
abstract: Results of studies on the antitumor activity of six 9-aminoacridine derivatives, four 3-nitro-9-aminoacridine derivatives, four 1-nitro-9-aminoacridine derivatives and five N-oxide of 1-nitro-9-aminoacridine derivatives in mice bearing Sa-180 of compound C-709 requires confirmation by further tests with Sa-180. The remaining 15 compounds were inactive. Some other general effects in the mice and some aspects of the structure-activity relationship are discussed.
mesh_terms: D000166:Acridines; D000818:Animals; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D055598:Chemical Phenomena; D002621:Chemistry; D004353:Drug Evaluation, Preclinical; D007680:Kidney Neoplasms / Q000188:drug therapy; D008113:Liver Neoplasms / Q000188:drug therapy; D051379:Mice; D008807:Mice, Inbred BALB C; D012510:Sarcoma 180 / Q000188:drug therapy*; D012513:Sarcoma, Experimental / Q000188:drug therapy; D013160:Splenic Neoplasms / Q000188:drug therapy; D013329:Structure-Activity Relationship
chemical_list: D000166:Acridines; D000970:Antineoplastic Agents