Mechanism of action of retinyl compounds on wound healing IV: effect of desmethylretinoic acid and its vinylogs on granuloma formation.
The effect of side-chain length of desmethylretinoic acid on granuloma formation induced by implantation of cotton pellets was studied. As in the homologous series of retinoic acid studies, compounds with side chains shorter than retinoic acid were not active while compounds with side chains as long or longer than retinoic acid were active. The compound with a chain two carbons longer than retinoic acid was the most active. The hydroxyproline and hexosamine contents of the granuloma were analyzed. The mechanisms of action of these active compounds on wound healing are discussed.
D000818:Animals; D055598:Chemical Phenomena; D002621:Chemistry; D003368:Gossypium; D006099:Granuloma / Q000188:drug therapy* / Q000378:metabolism; D006595:Hexosamines / Q000378:metabolism; D006909:Hydroxyproline / Q000378:metabolism; D051381:Rats; D014212:Tretinoin / Q000031:analogs & derivatives* / Q000627:therapeutic use; D014753:Vinyl Compounds / Q000627:therapeutic use; D014801:Vitamin A / Q000031:analogs & derivatives*
D006595:Hexosamines; D014753:Vinyl Compounds; D014801:Vitamin A; D014212:Tretinoin; D006909:Hydroxyproline