title: The alteration of osteoclast morphology by diphosphonates in bone organ culture.
abstract: Two diphosphonates alter the morphology of the osteoclast, as they inhibit the calcium45 release from bones stimulated to resorb by lipopolysaccharide. Disodium dichloromethylene diphosphonate was more potent than disodium ethane-1-hydroxy-1, 1-diphosphonate in both inhibiting 45calium release and altering osteoclast morphology. Alteration in the morphology of osteoclasts is associated with little or no change in the morphology of the surrounding non-osteoclast cells. These results indicate a specific morphological effect of diphosphonates on osteoclasts.
mesh_terms: D000818:Animals; D001862:Bone Resorption; D002118:Calcium / Q000378:metabolism; D002467:Cell Nucleus / Q000648:ultrastructure; D004305:Dose-Response Relationship, Drug; D008070:Lipopolysaccharides / Q000494:pharmacology; D009924:Organ Culture Techniques; D063065:Organophosphonates / Q000494:pharmacology*; D010010:Osteoclasts / Q000187:drug effects* / Q000378:metabolism / Q000648:ultrastructure; D051381:Rats
chemical_list: D008070:Lipopolysaccharides; D063065:Organophosphonates; D002118:Calcium