[A slide ruler and nomogram for calculations in cumulation kinetics of cardiac glycosides (author's transl)].
1. Substance I, whose elimination we can approximate with an exponential function, is active in the organism. 2. At a given moment substance II with the same onset of action whose elimination we also can approximate with an exponential function but different from substance I, starts to be added at regular intervals. 3. The relative levels of the two substances can be added up. 4. The optimal dose-scheme for the most regular effect is to be sought.


RESULTS
According to the relations derived in repost (5) published previously a slide ruler and a nomogram are constructed by the authors for that purpose. The scales are described as well as how to work with them. Some examples are included. The slide ruler and the nomogram are suitable for some further calcaulations in cumulation kinetics, which is briefly mentioned. These expedients are mainly meant for the application of cardiac glycosides. The same principle can be used in all cases to which the assumptions mentioned above apply.
D002301:Cardiac Glycosides / Q000097:blood / Q000378:metabolism* / Q000652:urine; D004347:Drug Interactions; D006801:Humans; D007700:Kinetics; D008433:Mathematics / Q000295:instrumentation*
D002301:Cardiac Glycosides
Rechenschieber und Nimogranm für Berechnungen aus der Kumulationskinetik der Herzglykoside