[Influence of immobilization and 3(beta-aminoethyl)-1, 2, 4-triazole on the calcium level in the tissues of the stomach of guinea pigs during the formation of experimental ulcers].
The Ca2+ ions content in the blood plasma and gastric tissues of guinea pigs during experimental ulceration provoked by a 12-hour immobilation or through introduction of 3(beta-aminoethyl)-1,2,4-triazol--a histamine analogue--was measured by using atom absorption spectrophotometry. A sharp fall in the concentration of calcium in gastric tissues upon immobilization down to 79 per cent (317 gamma/g) and after administration of the histamine analogue--down to 71 per cent (287 gamma/g. Similar shifts were seen to occur in the blood plasma as well. According to the authors this implies that under the effect of different action the tissular dystrophy develops by following a common mechanism with involvement not only of the adenylcyclase system, but of the calcium ions metabolism as well.
D002118:Calcium / Q000097:blood / Q000378:metabolism*; D007103:Immobilization; D013270:Stomach / Q000187:drug effects; D013276:Stomach Ulcer / Q000378:metabolism*; D014230:Triazoles / Q000494:pharmacology*
D014230:Triazoles; D002118:Calcium
Vliianie imobilizatsii i 3(beta-aminoétil)-1,2,4-triazola na soderzhanie kal'tsiia v tkaniakh zheludka morskikh svinok pri obrazovanii éksperimental'nykh iazv