title: [Tissue reactions in children treated with hemodynamic dextran and detoxication polyvinylpyrrolidone plasma substitutes].
abstract: By means of light and electron microscopy tissue reactions produced by repeated use of polyvinylpyrrolidone (PVP) and dextran plasma substitutes are studied on the material of 20 autopsies and 4 biopsies as well as in 65 experimental cases. Delayed type of PVP accumulation in tissues after the hemodes administration is determined as well as its dependence on the dose, time, kidney function and the presence of inflammatory foci. The differences in tissue reactions after administration of dextran and PVP substitutes are established. The results indicate that medicinal thesaurismosis may develop only after repeated infusions of PVP substitutes, while dextran accumulation is of a transitory type and results in characteristic morphological changes in the renal epithelium only.
mesh_terms: D000293:Adolescent; D000818:Animals; D001706:Biopsy; D002648:Child; D002675:Child, Preschool; D003911:Dextrans / Q000009:adverse effects*; D004305:Dose-Response Relationship, Drug; D006439:Hemodynamics / Q000187:drug effects*; D006801:Humans; D007223:Infant; D007249:Inflammation / Q000473:pathology; D007668:Kidney / Q000187:drug effects / Q000473:pathology; D008854:Microscopy, Electron; D011205:Povidone / Q000009:adverse effects*; D011817:Rabbits
chemical_list: D003911:Dextrans; D011205:Povidone
vernacular_title: Tkanevye reaktsii pri ispol'zovanii gemodinamicheskikh dekstranovykh i dezintoksikatsionnykh polivinilpirrolidonovykh zameniteleĭ plazmy krovi u deteĭ.