Effects of protease inhibitors in experimental septic shock.
Endotoxin shock and contact system activation were used to study effects of hirudin, antithrombin III, eglin C, aprotinin, and [Arg15]-aprotinin in anesthetized pigs. Alterations in the systemic and pulmonary circulation were in part prevented by administration of the inhibitors.
D000818:Animals; D007611:Aprotinin / Q000493:pharmacokinetics / Q000494:pharmacology / Q000627:therapeutic use; D016264:Dextran Sulfate; D024764:Hirudin Therapy; D006629:Hirudins / Q000494:pharmacology; D008070:Lipopolysaccharides; D011480:Protease Inhibitors / Q000494:pharmacology*; D011506:Proteins; D011994:Recombinant Proteins / Q000494:pharmacology; D015842:Serine Proteinase Inhibitors / Q000494:pharmacology / Q000627:therapeutic use; D015843:Serpins; D012772:Shock, Septic / Q000139:chemically induced / Q000188:drug therapy / Q000503:physiopathology*; D013552:Swine; D013556:Swine, Miniature
D006629:Hirudins; D008070:Lipopolysaccharides; D011480:Protease Inhibitors; D011506:Proteins; D011994:Recombinant Proteins; D015842:Serine Proteinase Inhibitors; D015843:Serpins; C028656:eglin proteinase inhibitors; D016264:Dextran Sulfate; D007611:Aprotinin