Defective protein synthesis of S-30 fraction of reticulocytes of anemic b/b rats.
The preincubated S-30 fraction from reticulocytes of anemic b/b rats is not able to promote the synthesis of proteins in the presence of hemoglobin RNA provided either from the reticulocytes of phenylhydrazine-treated rats or from the reticulocytes of anemic b/b rats. It was observed that poly(U)-directed polyphenylalanine synthesis is negligible in the same system, suggesting the existence of some alteration in regulatory machinery for protein synthesis in the reticulocytes of the anemic b/b rats.
D000740:Anemia / Q000139:chemically induced / Q000235:genetics / Q000378:metabolism*; D000818:Animals; D001798:Blood Proteins / Q000096:biosynthesis*; D002499:Centrifugation, Density Gradient; D002642:Chick Embryo; D007700:Kinetics; D010659:Phenylhydrazines; D014176:Protein Biosynthesis; D051381:Rats; D011919:Rats, Inbred Strains; D012156:Reticulocytes / Q000378:metabolism*
D001798:Blood Proteins; D010659:Phenylhydrazines