Individual variation in mushroom poisoning induced in the male rate by Cortinarius speciosissimus.
The renal toxicity of a homogenate of Cortinarius speciosissimus was studied in male rats after oral administration of 100, 500 and 1,000 mg of dried mushroom/kg body weight. Great individual variation in response to the mushroom toxins was observed. At high doses (500 mg/kg and 1,000 mg/kg) the percentage of treated animals which showed renal damage did not increase in proportion of the dose. 20--30% of the rats appeared to be resistant to the toxins of C. speciosissimus, even after large doses. However, in those animals which were affected the severity of renal damage was dose-dependent. The great individual variation in the response to C. speciosissimus toxins could be explained by genetic variation.
D000818:Animals; D007668:Kidney / Q000033:anatomy & histology; D007672:Kidney Cortex / Q000473:pathology; D007679:Kidney Medulla / Q000473:pathology; D007684:Kidney Tubules / Q000473:pathology; D008297:Male; D009145:Mushroom Poisoning / Q000150:complications* / Q000473:pathology; D009393:Nephritis / Q000209:etiology* / Q000473:pathology; D009929:Organ Size; D051381:Rats