A radioprotective effect of calcium chloride in combination with cystamine, mexamine, and hypoxemic hypoxia in mice.
A mild protective effect of a solution of CaCl2 (3.21 g%) injected in a volume of 0.2 ml i.p. 30 minutes prior to irradiation was demonstrated in experiments with male mice in the strain C 57 B1/10. The pre-irradiation administration of CaCl2 increased the LD50/30 by approximately 60R as compared with control animals, to which an isoosmotic NaCl solution was injected. A more pronounced decrease of the post-irradiation mortality of the animals was reached by combined administration of CaCl2 with chemical protectors- cystamine or mexamine administered in relatively low s.c. doses, as well as by a combination of CaCl2 with the protective action of hypoxemic hypoxia. Under the conditions of combined protection, the administration of CaCl2 increased LD50/30 by approximately 100 to 130R. A higher rate of formation of endogenous spleen hematopoietic colonies was observed in the animals protected by calcium. Possible mechanisms of the radioprotective effect of calcium on the level of the hematopoietic stem cells are discussed.
D000818:Animals; D002122:Calcium Chloride / Q000494:pharmacology*; D003538:Cystamine / Q000494:pharmacology; D004357:Drug Synergism; D006412:Hematopoietic Stem Cells; D000860:Hypoxia; D007552:Isotonic Solutions; D007928:Lethal Dose 50; D008297:Male; D008738:Methyl Ethers / Q000494:pharmacology; D051379:Mice; D008810:Mice, Inbred C57BL; D011837:Radiation-Protective Agents / Q000494:pharmacology*; D014363:Tryptamines / Q000494:pharmacology
D007552:Isotonic Solutions; D008738:Methyl Ethers; D011837:Radiation-Protective Agents; D014363:Tryptamines; D002122:Calcium Chloride; D003538:Cystamine