title: [Kinetics of chondrocyte proliferation in cartilaginous anlagen and in forming skeletal metaepiphyseal cartilage of mammalian extremities].
abstract: Changes of proliferative properties of the cartilage cells were observed from the beginning of the formation of chondroblastema till the formation of the joint and metaepiphysial cartilages by the method of autoradiography with H3-thymidin. The greatest amount of dividing chondrocytes is localized  in intermediate zones. In the metaepiphysial cartilage such cells form the proliferation zone and the duration of the mitotic cycle does not substantially differ from that of differentiating embryonic cells. The cells of the reserve zone of the metaepiphysial cartilage which are being formed are shown to be quite differentiated and to be at rest (phase G0). They can recommence division and stimulate general metabolic activity, replenishing the pool of proliferating chondrocytes. The duration of separate periods of the mitotic cycle for differentiating cells of different parts of the cartilage is calculated.
mesh_terms: D000818:Animals; D000831:Animals, Newborn / Q000033:anatomy & histology; D002455:Cell Division; D004247:DNA / Q000096:biosynthesis; D004622:Embryo, Mammalian / Q000033:anatomy & histology; D004838:Epiphyses / Q000254:growth & development*; D005121:Extremities / Q000033:anatomy & histology*; D005260:Female; D005333:Fetus / Q000033:anatomy & histology; D005865:Gestational Age; D007700:Kinetics; D008322:Mammals / Q000033:anatomy & histology*; D008938:Mitosis; D011247:Pregnancy; D011817:Rabbits; D051381:Rats; D013936:Thymidine / Q000378:metabolism; D013997:Time Factors; D014316:Tritium
chemical_list: D014316:Tritium; D004247:DNA; D013936:Thymidine
vernacular_title: Kinetika proliferatsii khondrotsitov khriashchevykh zakladok i formiruiushchegosia metaépifizarnogo khriashcha skeleta konechnosteĭ mlekopitaiushchikh