Syntheses of heterocylic fused thiazole acetic acids. 2.
A number of tricyclic and bicyclic fused thiazole-2-acetic acid derivatives were prepared and the chemistry and biological properties of these compounds are discussed. Many of the esters exhibited antitubercular activity. The bicyclic thiazole-2-acetic acids had antidepressant activity. Interesting antimetastatic activity against Lewis lung tumor in mice was found with several compounds, in particular, the thiazolo[3,2-a]benzimidazole-2-acetic acid derivative XI.
D000085:Acetates / Q000138:chemical synthesis / Q000627:therapeutic use; D000818:Animals; D000928:Antidepressive Agents / Q000138:chemical synthesis; D000970:Antineoplastic Agents / Q000138:chemical synthesis; D000995:Antitubercular Agents / Q000138:chemical synthesis; D001952:Bridged-Ring Compounds / Q000138:chemical synthesis / Q000627:therapeutic use; D006801:Humans; D051379:Mice; D009374:Neoplasms, Experimental / Q000188:drug therapy; D012110:Reserpine / Q000037:antagonists & inhibitors; D013844:Thiazoles / Q000138:chemical synthesis* / Q000627:therapeutic use
D000085:Acetates; D000928:Antidepressive Agents; D000970:Antineoplastic Agents; D000995:Antitubercular Agents; D001952:Bridged-Ring Compounds; D013844:Thiazoles; D012110:Reserpine