Parathyroid hormone and vertebral osteosclerosis in uremic patients.
Six out of 30 patients with chronic renal failure showed osteosclerosis in the lateral radiograph of the lumbar spine. When two groups with a similar degree of renal impairment were compared, the patients with osteosclerosis were younger and had a significantly higher level of circulating PTH (p less than 0.05) and total hydroxyproline excretion (p less than 0.02), than patients without overt osteosclerosis. The metacarpal cortical thickness was significantly reduced in patients with vertebral osteosclerosis. The results suggest that in patients with chronic uremia endogenous hypersecretion of PTH is one of the most significant factors responsible for the development of osteosclerosis. The mineral released from other skeletal sites could be utilized in the mineralization of the newly formed trabecular bone without any external calcium gain.
D000293:Adolescent; D000328:Adult; D000367:Age Factors; D003404:Creatinine / Q000378:metabolism; D005260:Female; D006801:Humans; D006909:Hydroxyproline / Q000652:urine; D007676:Kidney Failure, Chronic / Q000097:blood / Q000150:complications* / Q000652:urine; D008297:Male; D008875:Middle Aged; D010026:Osteosclerosis / Q000209:etiology*; D010281:Parathyroid Hormone / Q000097:blood*; D014511:Uremia / Q000097:blood / Q000150:complications* / Q000652:urine
D010281:Parathyroid Hormone; D003404:Creatinine; D006909:Hydroxyproline