title: Alaskan malamute chondrodysplasia. I. Bone composition studies.
abstract: Chondrodysplastic Alaskan Malamutes exhibit concentrations of calcium, phosphorus and magnesium in radius, ulna, and humerus bone segments similar to those of non-chondrodysplastic dogs of similar age. Significant differences in extractability of mineral components with 5% EDTA were observed in specific bone segments. Although these data suggest that a primary derangement in calcium and phosphorus was possible the magnitude of the differences strongly suggested it unlikely and stress or mechanical factors may account for some of the observed differences. The possibility that chondrodysplasia provides a model for human disorders such as fibrogenesis imperfecta ossium was discussed. These data presented support a previous hypothesis that the chondrodysplasia is not a vitamin D-resistant rickets syndrome.
mesh_terms: D000704:Analysis of Variance; D000818:Animals; D001842:Bone and Bones / Q000032:analysis*; D002113:Calcification, Physiologic; D004195:Disease Models, Animal; D004283:Dog Diseases / Q000378:metabolism*; D004285:Dogs; D008903:Minerals / Q000032:analysis*; D010009:Osteochondrodysplasias / Q000209:etiology / Q000378:metabolism*
chemical_list: D008903:Minerals