Possible hepatotoxicity of Doxidan.
A patient with chronic constipation developed liver injury and leukopenia following the ingestion of Doxidan, a combination drug consisting of danthron and dioctyl calcium sulfosuccinate. Evidence is presented that dioctyl calcium sulfosuccinate may have potentiated the toxicity. The liver injury was associated with deposition of IgE in the Kupffer cells. The mechanism of toxicity remains unclear.
D000328:Adult; D000880:Anthraquinones / Q000009:adverse effects* / Q000627:therapeutic use; D002400:Cathartics / Q000009:adverse effects* / Q000627:therapeutic use; D056486:Chemical and Drug Induced Liver Injury / Q000209:etiology* / Q000473:pathology; D003248:Constipation / Q000188:drug therapy; D004338:Drug Combinations; D005260:Female; D006801:Humans; D007073:Immunoglobulin E; D007970:Leukopenia / Q000139:chemically induced; D008099:Liver / Q000187:drug effects* / Q000473:pathology; D000442:Octanols / Q000009:adverse effects / Q000627:therapeutic use; D013386:Succinates / Q000009:adverse effects* / Q000627:therapeutic use
D000880:Anthraquinones; D002400:Cathartics; D004338:Drug Combinations; D000442:Octanols; D013386:Succinates; D007073:Immunoglobulin E; C004315:danthron