Damage to spermatogenesis in juvenile rat treated with DDVP and malathion.
Juvenile male rats received either 20 mg DDVP or 40 mg malathion/kg on the 4th and 5th day of life, and either 10 mg DDVP or 20 mg/kg malathion daily from the 4th to the 23rd day of life. The histological examination of the testes showed slight reductions of the spermatogentic cells and Leydig cells. Therefore, it is assumed that testosterone synthesis is reduced, followed by damage to spermatogentic cells. All disturbances return by normal by the 50th day of life.
D000818:Animals; D001835:Body Weight / Q000187:drug effects; D004006:Dichlorvos / Q000494:pharmacology*; D007985:Leydig Cells / Q000187:drug effects; D008294:Malathion / Q000494:pharmacology*; D008297:Male; D009929:Organ Size / Q000187:drug effects; D051381:Rats; D013090:Spermatocytes / Q000187:drug effects; D013091:Spermatogenesis / Q000187:drug effects*; D013737:Testis / Q000187:drug effects; D013997:Time Factors
D004006:Dichlorvos; D008294:Malathion