[Ultrastructural changes in the gallbladder mucous membrane during temporary experimental ischemia].
Temporary ischemia of the gall bladder was induced in rabbits by ligation of the gall bladder artery with silk. Histological examination revealed vascular disorders, such as hyperemia, blood stasis and focal hemorrhages. Electron microscopic studies showed the presence of increased number dark epithelial cells, expansion of intercellular area, loosening of the basal membrane and defects in it with invagination of the epithelial cells into the submucous layer. The most striking changes were discovered after a thrice-repeated 30-minute occlusion of the gall bladder artery. The degree of destructive changes proved to depend on the number of stimulated spasms (occlusions) and not on the duration of ischemia. This gives grounds to believe that multiple circulatory disorders participated in the complicated pathogenesis of cholecystitis.
D000818:Animals; D005704:Gallbladder / Q000098:blood supply* / Q000648:ultrastructure; D007511:Ischemia / Q000473:pathology*; D009092:Mucous Membrane / Q000648:ultrastructure; D011817:Rabbits
Izmeneniia ul'trastruktury slizistoĭ obolochki zhelchnogo puzyria pri vremennoĭ ishemii v éksperimente