Nonsuppressible insulin-like activity of human serum. A potent inhibitor of insulin degradation.
Nonsuppressible insulin-like activity soluble in acid ethanol (NSILA-s) is a well-characterized peptide derived from human serum which has previously been shown to have insulin-like bioactivity and react with both insulin and NSILA-s receptor sites in liver plasma membranes. In the present study we find that NSILA-s is also a potent competitive inhibitor of the insulin-degrading system of the liver plasma membrane. The most purified NSILA-s preparation tested was 20-fold more potent than insulin itself, and significant inhibition of insulin degradation occurred at concentrations of NSILA-s similar to those found in plasma.
D001667:Binding, Competitive; D001798:Blood Proteins / Q000494:pharmacology*; D002462:Cell Membrane / Q000378:metabolism; D006801:Humans; D007328:Insulin / Q000378:metabolism*; D008099:Liver / Q000378:metabolism*
D001798:Blood Proteins; D007328:Insulin