Effects of phototherapy on hepatic function in human alcoholic cirrhosis.
Phototherapy has been used to treat neonatal jaundice, but little assessment has been made of possible beneficial effects on adult liver disease. Effects of phototherapy on bile acid turnover, biliary lipid concentration, liver function tests, and bromosulfophthalein (BSP) kinetics were studied in 8 alcoholic cirrhotics. Phototherapy initially increased biliary specific activity of both primary bile acids and then produced an acceleration of cholic and chenodeoxycholic acid decay curves. Pruritus was relieved in the 3 patients who had this symptom. The proposed mechanism for these changes is mobilization of bile acids from an expanded cutaneous bile acid pool with augmented bile acid excretion. No significant change in serum liver function tests or BSP plasma disappearance curves was seen. Phototherapy causes little improvement in intrinsic liver function, but produces specific changes in bile acid metabolism; these changes may be related to effects of light on a cutaneous bile acid pool.
D000328:Adult; D000437:Alcoholism / Q000150:complications*; D001647:Bile Acids and Salts / Q000378:metabolism; D001663:Bilirubin / Q000378:metabolism; D002635:Chenodeoxycholic Acid / Q000378:metabolism; D006801:Humans; D007700:Kinetics; D050356:Lipid Metabolism; D008099:Liver / Q000503:physiopathology*; D008103:Liver Cirrhosis / Q000209:etiology / Q000503:physiopathology*; D008297:Male; D008875:Middle Aged; D010789:Phototherapy; D012867:Skin / Q000378:metabolism; D013448:Sulfobromophthalein
D001647:Bile Acids and Salts; D013448:Sulfobromophthalein; D002635:Chenodeoxycholic Acid; D001663:Bilirubin