Identification, in the external region of the rat median eminence, of separate neurophysin-vasopressin and neurophysin-oxytocin containing nerve fibres.
Immuno-enzyme cytochemical investigations, using single and double staining techniques, showed that the external region of the rat median eminence contains separate neurophysin-vasopressin fibres and neurophysin-oxytocin fibres. These neurophysin-hormone containing nerve fibres are influenced by bilateral adrenalectomy and by colchicine treatment. The external region of the median eminence of the homozygous Brattleboro rat contains neurophysin-oxytocin fibres. It does not contain immuno-reactive neurophysin-vasopressin fibres. Bilateral adrenalectomy also influences the neurophysin-vasopressin containing neurons of the suprachiasmatic nuclei. In the neurons of the parvicellular part of the rat hypothalamic paraventricular nuclei, staining for vasopressin and for oxytocin is completely absent.
D000315:Adrenalectomy; D000818:Animals; D001369:Axons / Q000032:analysis; D003078:Colchicine / Q000494:pharmacology; D003919:Diabetes Insipidus / Q000378:metabolism; D007030:Hypothalamo-Hypophyseal System / Q000032:analysis*; D008473:Median Eminence / Q000032:analysis* / Q000033:anatomy & histology; D009481:Neurophysins / Q000032:analysis*; D010121:Oxytocin / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains; D014667:Vasopressins / Q000378:metabolism*
D009481:Neurophysins; D014667:Vasopressins; D010121:Oxytocin; D003078:Colchicine