title: [The effect of Glipizide on the blood glucose and insulin in non-ketotic diabetes mellitus (author's transl)].
abstract: 9 patients suffering from non-ketotic diabetes were treated for 7 days with glipizide, a sulphonylurea derivative. A decrease in blood glucose level was observed in 6 patients during the course of the day, accompanied by an increase in immunoreactive insulin during the first half of the day and an increase in the insulinogenic index. In one patient with insulinopenic diabetes glipizide had only a very small effect on the blood glucose and insulin concentration. 2 patients suffering from insulin resistance caused by type IV hyperlipoproteinanemia and obesity showed an increase in insulin, but no decrease in blood glucose concentration. These results are a further indication that sulphonylurea agents should be administered only in the case of certain specific types of diabetes, because no therapeutic response can be expected in diabetes caused by insulinopenia and insulin resistance.
mesh_terms: D000328:Adult; D000368:Aged; D001786:Blood Glucose / Q000032:analysis; D003920:Diabetes Mellitus / Q000188:drug therapy*; D005913:Glipizide / Q000627:therapeutic use*; D006801:Humans; D006949:Hyperlipidemias / Q000150:complications; D007328:Insulin / Q000172:deficiency / Q000276:immunology; D007333:Insulin Resistance; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000150:complications; D013453:Sulfonylurea Compounds / Q000627:therapeutic use*; D014280:Triglycerides / Q000097:blood
chemical_list: D001786:Blood Glucose; D007328:Insulin; D013453:Sulfonylurea Compounds; D014280:Triglycerides; D005913:Glipizide
vernacular_title: Wirkung von Glipizid auf Blutglukose und Insulin beim nichtketotischen Diabetes mellitus