title: Suppression of a ligand operated membrane current by the epileptogenic agent pentylenetetrazol in oocytes of Xenopus laevis after injection of rat brain RNA.
abstract: The effects of the epileptogenic substance pentylenetetrazol (PTZ) on ligand operated membrane channels were studied. For this purpose serotonin (5-HT) sensitive channels were expressed in RNA injected oocytes of Xenopus laevis. With simultaneous application of both substances, the response to 5-HT was reduced and eventually abolished by PTZ with increasing concentrations (5-100 mM). A reduction of the 5-HT response also appeared when PTZ was applied in various intervals (15 and 240 s) before 5-HT. It may be assumed that PTZ produces a component of its epileptogenic effect by acting on ligand operated membrane channels.
mesh_terms: D000818:Animals; D001923:Brain Chemistry / Q000502:physiology*; D002462:Cell Membrane / Q000187:drug effects / Q000378:metabolism; D007473:Ion Channels / Q000187:drug effects*; D008024:Ligands; D009865:Oocytes / Q000187:drug effects / Q000378:metabolism*; D010433:Pentylenetetrazole / Q000494:pharmacology*; D012313:RNA / Q000494:pharmacology*; D051381:Rats; D014982:Xenopus laevis
chemical_list: D007473:Ion Channels; D008024:Ligands; D012313:RNA; D010433:Pentylenetetrazole