title: [A morphologic analysis of the manifestations of the effects of myelotransplantation].
abstract: The positive direct curative effect of grafting of the bone marrow in aplastic conditions of hemopoiesis is associated with rapid restoration of the myeloid tissue. Normalization of the hemopoiesis organs of recipients depends on the cellular mechanism of action of transplanted hemopoietic cells and a humoral stimulating effect of life-activity products of the survived transplanted cells. Widespread application of transplantation of allogenic heterologous bone marrow under clinical conditions is hindered by the development of secondary disease, frequently fatal for recipients. The major part of morphological changes in secondary disease are non-specific. Pathologo-anatomic diagnosis of chronic secondary disease may be established only with due regard for a compex analysis of the measures applied, clinical, hematological, immunological and morphological data.
mesh_terms: D000469:Alkaline Phosphatase / Q000378:metabolism; D000818:Animals; D004285:Dogs; D005260:Female; D006086:Graft vs Host Disease / Q000473:pathology; D006410:Hematopoiesis; D006651:Histocytochemistry; D006801:Humans; D051379:Mice; D011817:Rabbits; D011833:Radiation Injuries, Experimental / Q000628:therapy; D051381:Rats; D014184:Transplantation, Homologous
chemical_list: D000469:Alkaline Phosphatase
vernacular_title: Morfologicheskiĭ analiz proiavlenii éffektov mielotransplantatsii