Antinociceptive effect of mexiletine in diabetic mice.
We examined the effect of mexiletine on the threshold for pain perception as determined by the application of mechanical noxious stimuli (tail-pinch) in diabetic mice. Mexiletine produced a pronounced analgesic effect in diabetic mice in a dose-dependent manner. Mexiletine (10(-5)M) significantly inhibited the K(+)-evoked release of substance P from the slices of spinal cord of diabetic mice. These results suggest that the reduction of release of substance P from the nociceptive afferent terminal in the spinal cord is involved in the mechanisms of mexiletine analgesia in diabetic mice.
D000818:Animals; D003921:Diabetes Mellitus, Experimental / Q000188:drug therapy / Q000378:metabolism / Q000503:physiopathology*; D008297:Male; D008801:Mexiletine / Q000494:pharmacology*; D051379:Mice; D008813:Mice, Inbred ICR; D009619:Nociceptors / Q000187:drug effects*; D010146:Pain / Q000188:drug therapy / Q000378:metabolism / Q000503:physiopathology*; D011188:Potassium / Q000494:pharmacology; D011930:Reaction Time / Q000187:drug effects; D013373:Substance P / Q000187:drug effects
D008801:Mexiletine; D013373:Substance P; D011188:Potassium