Effect of bile salts and fatty acids on the colonic absorption of oxalate.
These studies were designed to evaluate the effect of bile salts and fatty acids on colonic oxalate absorption. Five millimolar deoxycholate significantly increased oxalate absorption from 34.2 +/- 9.4 nmoles per min per g dry weight to 330.4 +/- 47.3 (P less than 0.001) and changed water absorption to water secretion. Deoxycholate also increased the absorption of urea, decreased the electrical potential difference, and increased colonic clearance of oxalate, observations which are consistent with an increase in colonic mucosal permeability. In contrast, taurocholate did not increase oxalate absorption. Ricinoleic acid also significantly increased the absorption. These results suggest that bile salts and fatty acids increase colonic absorption of oxalate. Oleic acid had similar effects on oxalate absorption but was less effective than ricinoleic acid. Octanoic acid, a medium chain fatty acid, did not alter oxalate absorption of oxalate by a nonspecific alteration of mucosal permeability. These observations may further explain many of the clinical phenomena associated with enteric hyperoxaluria.
D000818:Animals; D001647:Bile Acids and Salts / Q000494:pharmacology*; D002210:Caprylates / Q000494:pharmacology; D003106:Colon / Q000187:drug effects / Q000378:metabolism*; D003840:Deoxycholic Acid / Q000494:pharmacology; D004594:Electrophysiology; D005227:Fatty Acids / Q000494:pharmacology*; D007408:Intestinal Absorption / Q000187:drug effects*; D008297:Male; D009829:Oleic Acids / Q000494:pharmacology; D010070:Oxalates / Q000378:metabolism*; D051381:Rats; D012277:Ricinoleic Acids / Q000494:pharmacology; D013656:Taurocholic Acid / Q000494:pharmacology; D014867:Water / Q000378:metabolism
D001647:Bile Acids and Salts; D002210:Caprylates; D005227:Fatty Acids; D009829:Oleic Acids; D010070:Oxalates; D012277:Ricinoleic Acids; D003840:Deoxycholic Acid; D014867:Water; D013656:Taurocholic Acid