Inhibition of prostaglandin potentiated formalin induced arthritis with non-steroid antiphlogistics.
The PGE2 potentiated formalin arthritis can be only temporarily influenced by indomethacin. Azapropazone had a good therapeutic effect on chronic inflammation. According to the enzyme histochemical studies, azapropazone enhanced oxidative enzyme activity. This phenomenon may be interpreted as a sign of a favorable effect.
D000818:Animals; D001032:Apazone / Q000494:pharmacology*; D001168:Arthritis / Q000139:chemically induced / Q000188:drug therapy* / Q000201:enzymology; D002358:Cartilage, Articular / Q000201:enzymology; D006651:Histocytochemistry; D007213:Indomethacin / Q000494:pharmacology*; D007596:Joints / Q000201:enzymology; D007770:L-Lactate Dehydrogenase / Q000378:metabolism; D008291:Malate Dehydrogenase / Q000378:metabolism; D008297:Male; D011458:Prostaglandins E / Q000037:antagonists & inhibitors*; D051381:Rats; D013385:Succinate Dehydrogenase / Q000378:metabolism; D014227:Triazines / Q000494:pharmacology*
D011458:Prostaglandins E; D014227:Triazines; D007770:L-Lactate Dehydrogenase; D008291:Malate Dehydrogenase; D013385:Succinate Dehydrogenase; D001032:Apazone; D007213:Indomethacin