Chlorampenicol retention on, and penetration into, the rabbit eye.
The retention of the antibiotic chloramphenicol on, and penetration into, the rabbit eye has been compared following administration in two vehicles. Samples were taken of both aqueous humor and a washing fluid applied to the conjunctival surface and the concentration of 14C-chloramphenicol determined. Greater tear film and aqueous humor drug concentrations, which are effective against many organisms, were found with a vehicle which enhanced retention time on the ocular surfaces.
D000818:Animals; D001082:Aqueous Humor / Q000378:metabolism; D001881:Borates / Q000008:administration & dosage; D001888:Boric Acids / Q000008:administration & dosage; D003315:Cornea / Q000378:metabolism; D005123:Eye / Q000378:metabolism*; D009883:Ophthalmic Solutions; D014677:Pharmaceutical Vehicles; D011817:Rabbits; D013997:Time Factors
D001881:Borates; D001888:Boric Acids; D009883:Ophthalmic Solutions; D014677:Pharmaceutical Vehicles