Aminooxyacetic acid causes selective neuronal loss in layer III of the rat medial entorhinal cortex.
Aminooxyacetic acid (AOAA) was used to produce a selective lesion in the rat entorhinal cortex (EC). As assessed 7 days following the injection of AOAA (75 micrograms/0.75 microliter) into the EC, neuronal loss in layer III of the medial EC, particularly in its ventral portion, was consistently observed in Nissl-stained horizontal sections. This selective neurodegeneration was seen even when AOAA was injected laterally or in deeper layers. Behavioral seizures occurred between 2 and 4 h after the AOAA injection. AOAA-induced EC lesions may provide experimental models for the study of human diseases in which the EC, particularly layer III neurons, is involved.
D000625:Aminooxyacetic Acid / Q000494:pharmacology*; D000818:Animals; D001522:Behavior, Animal / Q000502:physiology; D002540:Cerebral Cortex / Q000166:cytology* / Q000187:drug effects; D005911:Gliosis / Q000473:pathology; D008297:Male; D009474:Neurons / Q000187:drug effects*; D051381:Rats; D017207:Rats, Sprague-Dawley; D013194:Staining and Labeling
D000625:Aminooxyacetic Acid