Effects of mazindol, a non-phenylethylamine anorexigenic agent, on biogenic amine levels and turnover rate.
1 Mazindol is a new anorexigenic agent which possesses a different chemical structure from that of phenylethylamines, but shows a pharmacological profile similar to that of (+)-amphetamine. 2 Mazindol neither altered whole brain monoamine levels (noradrenaline (NA), dopamine, 5-hydroxytryptamine (5-HT)) nor changed NA levels in the hypothalamus or dopamine levels in the caudate nucleus. 3 Mazindol enhanced dopamine turnover rate in the caudate nucleus, as shown by the increased rate of dopamine decline after blockade of catecholamine synthesis by alpha-methyl-p-tyrosine and decreased the conversion index of (3H)-tyrosine into brain NA. 4 Mazindol administration did not modify pargyline-induced decline of 5-hydroxyindoleacetic acid suggesting that 5-HT turnover is not altered by this drug.
D000818:Animals; D001679:Biogenic Amines / Q000032:analysis* / Q000378:metabolism; D001923:Brain Chemistry / Q000187:drug effects*; D002421:Caudate Nucleus / Q000378:metabolism; D003342:Corpus Striatum / Q000378:metabolism; D004298:Dopamine / Q000378:metabolism; D006897:Hydroxyindoleacetic Acid / Q000378:metabolism; D007211:Indoles / Q000494:pharmacology*; D007700:Kinetics; D008297:Male; D008454:Mazindol / Q000494:pharmacology*; D008781:Methyltyrosines / Q000494:pharmacology; D009638:Norepinephrine / Q000378:metabolism; D010293:Pargyline / Q000494:pharmacology; D051381:Rats; D012701:Serotonin / Q000378:metabolism
D001679:Biogenic Amines; D007211:Indoles; D008781:Methyltyrosines; D012701:Serotonin; D006897:Hydroxyindoleacetic Acid; D010293:Pargyline; D008454:Mazindol; D004298:Dopamine; D009638:Norepinephrine