title: The polymerization of actin. II. How nonfilamentous actin becomes nonrandomly distributed in sperm: evidence for the association of this actin with membranes.
abstract: At an early stage in spermiogenesis the acrosomal vacuole and other organelles including ribosomes are located at the basal end of the cell. From here actin must be transported to its future location at the anterior end of the cell. At no stage, in the accumulation of actin in the periacrosomal region is the actin sequested in a membrane-bounded compartment such as a vacuole or vesicle. Since filaments are not present in the periacrsomoal region during the accumulation of the actin even though the fixation of these cells is sufficiently good to distinguish actin filaments in thin section, the actin must accumulate in the nonfilamentous state.
mesh_terms: D000177:Acrosome / Q000648:ultrastructure; D000199:Actins / Q000032:analysis / Q000378:metabolism*; D000818:Animals; D002467:Cell Nucleus / Q000648:ultrastructure; D006018:Glycols / Q000494:pharmacology; D008297:Male; D008566:Membranes / Q000378:metabolism / Q000648:ultrastructure; D011092:Polyethylene Glycols / Q000494:pharmacology; D012671:Seminiferous Tubules / Q000648:ultrastructure; D013087:Spermatids / Q000648:ultrastructure; D013091:Spermatogenesis; D013094:Spermatozoa / Q000187:drug effects / Q000648:ultrastructure*
chemical_list: D000199:Actins; D006018:Glycols; D011092:Polyethylene Glycols