Fatal myeloencephalopathy due to intrathecal vincristine administration.
Vincristine was accidentally given intrathecally to a child with leukaemia, producing sensory and motor dysfunction followed by encephalopathy and death. Separate times for administering vincristine and intrathecal therapy is recommended.
D002493:Central Nervous System Diseases / Q000139:chemically induced*; D006801:Humans; D007223:Infant; D007278:Injections, Spinal; D008297:Male; D008508:Medication Errors; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000188:drug therapy; D014750:Vincristine / Q000008:administration & dosage / Q000009:adverse effects* / Q000627:therapeutic use
D014750:Vincristine