Histologic and histochemical changes in the aorta and myocardium of rats under the influence of atherogenic diet and phosphatidylcholine (EPL).
The prophylactic and therapeutic action of EPL on arteriosclerotic changes induced with fat-rich diet in the aorta and myocardium of white rats was studied. Histologic and histochemical studies showed that EPL administered prophylactically in doses of 280 mg/kg and 900 mg/kg body weight does not significantly inhibit development of arteriosclerotic lesions if fat-rich diet is continued. A distinct prophylactic action of EPL was first seen at a dosage of 2800 mg/kg. The therapeutic action of EPL on pathologic changes in the blood vessels also depends on dosage. The higher the dosage of EPL, the less pronounced the changes. At a dosage level of 2800 mg/kg, changes are slight and sporadic.
D000818:Animals; D001011:Aorta / Q000201:enzymology / Q000473:pathology*; D001161:Arteriosclerosis / Q000517:prevention & control*; D004036:Diet, Atherogenic; D004195:Disease Models, Animal; D004305:Dose-Response Relationship, Drug; D005260:Female; D006651:Histocytochemistry; D008297:Male; D009206:Myocardium / Q000201:enzymology / Q000473:pathology*; D010088:Oxidoreductases / Q000378:metabolism; D010713:Phosphatidylcholines / Q000008:administration & dosage / Q000627:therapeutic use*; D051381:Rats
D010713:Phosphatidylcholines; D010088:Oxidoreductases