The distribution and kinetics of sulphacetamide in leukaemic mice.
1 During the first 90 min following oral administration of sulphacetamide, there was a rapid decline in plasma drug concentration in control mice whereas a progressive increase in sulphacetamide concentration was observed in leukaemic mice. 2 Similar changes in the kinetics of sulphacetamide distribution were observed in the liver, spleen and muscle. 3 While the concentration of sulphacetamide remained quite constant in the brain and fat tissue of control mice, a progressive increase in drug concentration was observed in the brain and fat tissue of leukaemic mice. 4 Some of these changes in the kinetics of sulphacetamide tissue distribution are compatible with delay in gastrointestinal absorption of the drug and its accumulation in the ascitic fluid.
D000273:Adipose Tissue / Q000378:metabolism; D000818:Animals; D001202:Ascitic Fluid / Q000378:metabolism; D001921:Brain / Q000378:metabolism; D006207:Half-Life; D007408:Intestinal Absorption; D007700:Kinetics; D007939:Leukemia L1210 / Q000378:metabolism*; D008099:Liver / Q000378:metabolism; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D013154:Spleen / Q000378:metabolism; D013409:Sulfacetamide / Q000378:metabolism*
D013409:Sulfacetamide