title: Single-tablet enantiomeric purity assay of amphetamine by rotation enhancement.
abstract: Enhancement of the optical rotation of dextroamphetamine by production of an optically active chromophore through reaction with 1-fluoro-2,4-dinitrobenzene to give alpha-methPYL-N-(2,4-dinitrophenyl)-beta-phenylethylamine is reported. This reaction forms the basis of an assay for both the content and optical purity of dextroamphetamine sulfate at single-dose levels (5 mg). Results of assays of standard solutions and of commercial tablets demonstrate the suitability of the method for the determination of enantiomeric purity and amphetamine content.
mesh_terms: D003913:Dextroamphetamine / Q000032:analysis*; D007536:Isomerism; D008722:Methods; D009904:Optical Rotation; D013607:Tablets / Q000032:analysis
chemical_list: D013607:Tablets; D003913:Dextroamphetamine