title: [The influence of aconitine on several properties of the sodium channels of the membranes of nodes of Ranvier].
abstract: Effect of aconitine on the sodium channels in the frog Ranvier node membrane was studied. Aconitine was shown to produce two types of modified channels. The first type channels acquire stable properties after effect was developed; they open at high  negative voltage, their inactivation, if any, is incomplete, their selectivity is greatly  reduced: the potassium-sodium permeability ratio averages to 0.72. The second type channels turn impermeable as effect develops, their kinetics and conductance-voltage dependance are similar to those of normal sodium channels; as compared with normal channels their selectivity is reduced: the potassium permeability ratio averages to 0.22. Both aconitine-modified and normal channels have the same sensitivity  to tetrodotoxin.
mesh_terms: D000157:Aconitine / Q000494:pharmacology*; D031841:Aconitum / Q000031:analogs & derivatives*; D000818:Animals; D001693:Biological Transport, Active / Q000187:drug effects; D002463:Cell Membrane Permeability / Q000187:drug effects*; D011188:Potassium / Q000378:metabolism; D011898:Ranidae; D011901:Ranvier's Nodes / Q000187:drug effects* / Q000378:metabolism; D012964:Sodium / Q000378:metabolism*
chemical_list: D012964:Sodium; D011188:Potassium; D000157:Aconitine
vernacular_title: Vliianie akonitina na nekotorye svoĭstva natrievykh kanalov membrany perekhvata Ranv'e