[Allergenic action of armin].
The allergic effect of armine--ethyl paranitrophenyl ether of the ethylpohosphinic acid--was studied. Armine was injected subcutaneously in doses of 0.1, 0.01, 0.005 and 0.0005 mg/kg to guinea pigs 5-6 times at intervals of 2-3 days. The challenging introduction of armine in a dose equalling the sensitizing one produced an anaphylactic shock in a group of animals sensitized with single doses of 0.005 and 0.0005 mg/kg. The allergic nature of these reactions was also confirmed by a large number of positive results secondary to immunological tests preceding the challenging dose, viz. by degranulation of mast cells, agglomeration of leucocytes and passive skin anaphylaxis.
D000485:Allergens / Q000494:pharmacology*; D000818:Animals; D004305:Dose-Response Relationship, Drug; D006168:Guinea Pigs; D007114:Immunization; D007279:Injections, Subcutaneous; D009596:Nitrophenols / Q000276:immunology*; D009943:Organophosphorus Compounds / Q000276:immunology*; D013997:Time Factors
D000485:Allergens; D009596:Nitrophenols; D009943:Organophosphorus Compounds
Ob allergennom deĭstvii armina