Lens growth in the Nakano mouse.
The growth curve of the lens of the Nakano mouse was compared to that of the normal mouse. There was no obvious difference for the first two weeks of age. After this period the growth of the normal lens continued while that of Nakano mouse lens slowed abruptly and eventually ceased. Studies with labeled leucine, however, showed that even after the appearance of the "pin-head" opacity the protein synthesis, although depressed, continued. These findings combined with previous histological observations suggest that new fiber formation is probably unaffected in the early stages of the Nakano cataract. The apparent cessation of lens growth is probably associated with the extensive liquefaction that is observed to occur at the posterior nuclear region.
D000375:Aging; D000818:Animals; D002386:Cataract / Q000378:metabolism / Q000473:pathology*; D003459:Crystallins / Q000096:biosynthesis; D007908:Lens, Crystalline / Q000254:growth & development* / Q000378:metabolism; D007930:Leucine / Q000378:metabolism; D051379:Mice
D003459:Crystallins; D007930:Leucine