Influence of trichlorfon and fractionated irradiation on hydroproteolytic activity of pancreas and intestinal tissues of rats.
Investigations into the hydroproteolytic activity of pancreas and intestinal tissues (small intestine and colon) of rats after fractionated irradiation (5 X 150 R) were carried out. There was found marked postirradiation enhancement of lipase activity in pancreas and duodenal part of intestine and increase of B-glucuronidase and acid phosphatase activity in nearly all parts of the examined intestinal tissues. Fractionated irradiation resulted in an increase of pancreatic catheptic (proteolytic) activity causing simultaneous decrease of proteolytic activity in intestine and colon. Preventive administration of Trichlorfon (ten days before irradiation) in the dose of 10 mg or 30 mg/kg evoked modification of hydroproteolytic activity in intestinal tissues of healthy  and irradiated rats. Trichlorfon applied in the dose of 30 mg/kg exerted antilipolytic and anticatheptic effects in pancreas and intestinal tissues of irradiated rats.
D000135:Acid Phosphatase / Q000378:metabolism; D000818:Animals; D003106:Colon / Q000187:drug effects / Q000201:enzymology / Q000528:radiation effects; D005260:Female; D007421:Intestine, Small / Q000187:drug effects / Q000201:enzymology / Q000528:radiation effects; D007422:Intestines / Q000528:radiation effects*; D008049:Lipase / Q000378:metabolism; D010179:Pancreas / Q000187:drug effects / Q000201:enzymology / Q000528:radiation effects*; D011830:Radiation Effects; D051381:Rats; D013997:Time Factors; D014236:Trichlorfon / Q000494:pharmacology*
D014236:Trichlorfon; D008049:Lipase; D000135:Acid Phosphatase