[The action mechanism of heparin in the increase of radiation resistance of mice].
Repeated intraperitoneal heparin injections given to mice prior to a whole-body irradiation with 650 R reduce the blood coagulation time between the seventh and the 19th day after radiation injury as compared to untreated animals exposed to radiation. Controls, not having been irradiated, didn't show any measurable effect after repeated heparin administration in 60 per cent of the experimental animals, whereas in 40 per cent the hematocrit value decreased to about two thirds of the normal, this probably being caused by internal hemorrhages. The increase in radiation resistance of mice, following administration of heparin, therefore may be due to a stimulation of the hematopoietic system, beginning already before exposure.
D000818:Animals; D001777:Blood Coagulation / Q000187:drug effects; D006400:Hematocrit; D006410:Hematopoiesis / Q000187:drug effects; D006493:Heparin / Q000494:pharmacology*; D007274:Injections, Intraperitoneal; D008297:Male; D051379:Mice; D011837:Radiation-Protective Agents / Q000494:pharmacology*; D013997:Time Factors
D011837:Radiation-Protective Agents; D006493:Heparin
Zum Wirkungsmechanismus des Heparins bei der Strahlenresistenzerhöhung von Mäusen