Significant reduction in the incidence of phlebitis with buffered versus unbuffered cephalothin.
Cephalothin (1 g every 2 h), buffered cephalothin, and diluent alone (5% dextrose in water) were each administered for 4 days intravenously to 12 volunteers in a double-blind crossover study. The incidence of phlebitis with buffered cephalothin was significantly lower than that with unbuffered drug (P < 0.01) and almost identical to the incidence with diluent alone.
D000328:Adult; D002021:Buffers; D002512:Cephalothin / Q000009:adverse effects*; D005947:Glucose / Q000009:adverse effects; D006801:Humans; D008297:Male; D010689:Phlebitis / Q000139:chemically induced*
D002021:Buffers; D005947:Glucose; D002512:Cephalothin