Effects of chronic administration of polybrominated biphenyls on parameters associated with hepatic drug metabolism.
Parameters relating to hepatic microsomal drug metabolism were measured in vitro following 2 weeks exposure of rats to polybrominated biphenyls (PBB) as a dietary supplement at 4.69, 18.75, 75 and 300 ppm. The mixture of PBB was a potent inducer of hepatic microsomal drug metabolism. The pattern of induction seen after PBB exposure was compared with that produced by phenobarbital and 3-methyl-cholanthrene and the pattern of induction observed shared similarities with both of these agents.
D000818:Animals; D001713:Biphenyl Compounds / Q000494:pharmacology*; D004032:Diet; D004790:Enzyme Induction / Q000187:drug effects; D005260:Female; D006128:Growth / Q000187:drug effects; D008099:Liver / Q000187:drug effects / Q000201:enzymology*; D008748:Methylcholanthrene / Q000494:pharmacology; D006899:Mixed Function Oxygenases / Q000378:metabolism*; D010088:Oxidoreductases / Q000378:metabolism*; D010634:Phenobarbital / Q000494:pharmacology; D051381:Rats
D001713:Biphenyl Compounds; D008748:Methylcholanthrene; D006899:Mixed Function Oxygenases; D010088:Oxidoreductases; D010634:Phenobarbital