[Study using the probit-analysis method of the process of increasing resistance to dipin and bruneomycin in Fisher L-5178 lymphadenosis cells in experiments on animals].
The study of the process of resistance induction in the cells of lymphadenosis to dipin (subline L-5178/D) and bruneomycin (subline L-5178/B) showed that with increasing of the resistance relation between the drug dose and the antitumor effect gradually faded. It was found that only at the first stages of induction of the resistance increase may be found by comparison of values ED50 and ED70 of the lymphadenosis sensitive strain and its resistant sublines. The probit-analysis method provided registration of the resistance increase also at later stages. In this case the resistance level may be estimated by the slope of the dose-response curve.
D000818:Animals; D002460:Cell Line; D002471:Cell Transformation, Neoplastic / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D004351:Drug Resistance; D008223:Lymphoma / Q000188:drug therapy*; D008722:Methods; D051379:Mice; D009368:Neoplasm Transplantation; D009374:Neoplasms, Experimental / Q000188:drug therapy; D010879:Piperazines / Q000008:administration & dosage / Q000037:antagonists & inhibitors*; D013308:Streptonigrin / Q000008:administration & dosage / Q000037:antagonists & inhibitors*; D013997:Time Factors
D010879:Piperazines; D013308:Streptonigrin
Izuchenie s pomoshch'iu metoda probit-analiza protsessa narastaniia ustoĭchivosti u kletok limfadenoza Fishera L-5178 k dipinu i bruneomitsinu v opytakh na zhivotnykh