Antileukemic effects of pseudoisocytidine, a new synthetic pyrimidine C-nucleoside.
Pseudoisocytidine, a new synthetic pyrimidine C-nucleoside, which might be considered a more stable analog of 5-azacytidine, is active in vitro and in vivo, i.p. and p.o., against various 1-beta-D-arabinofuranosylcytosine-resistant lines of mouse leukemia. This antileukemic activity is blocked by cytidine but not by deoxycytidine or thymidine.
D000818:Animals; D002460:Cell Line; D002478:Cells, Cultured; D003562:Cytidine / Q000037:antagonists & inhibitors / Q000627:therapeutic use*; D003841:Deoxycytidine / Q000494:pharmacology; D004353:Drug Evaluation, Preclinical; D007536:Isomerism; D007942:Leukemia, Experimental / Q000188:drug therapy*; D051379:Mice; D008810:Mice, Inbred C57BL; D008811:Mice, Inbred DBA; D009374:Neoplasms, Experimental / Q000209:etiology; D013936:Thymidine / Q000494:pharmacology
D003841:Deoxycytidine; D003562:Cytidine; C012518:pseudoisocytidine; D013936:Thymidine