title: Direct measurement of octanol-water partition coefficients by high-pressure liquid chromatography.
abstract: A technique is presented for the direct measurement of octanol-water partition coefficients by HPLC. The method involves running solutes in octanol-saturated water as the mobile phase against water-saturated octanol entrained on an inert support. Log P correlates linearly with log tc for a number of standards. The measurable range in log P (so far) is -0.3 to +3.7. A critical review of chromatographic methods in Hansch analysis is given.
mesh_terms: D002627:Chemistry, Physical / Q000379:methods*; D002851:Chromatography, High Pressure Liquid; D007700:Kinetics; D000442:Octanols; D014867:Water
chemical_list: D000442:Octanols; D014867:Water