Tissue plasminogen activator in the pathogenesis of protein-losing gastroenteropathy.
Tissue fibrinolytic activity, mainly due to activator of tissue plasminogen was increased in the biopsied gastric mucosa of patients with protein-losing gastropathy. Antiplasmin therapy with trans-AMCHA (trans-4-aminomethyl cyclohexane carboxylic acid) was dramatically effective, except in the case of a patient with intestinal lymphangiectasia. These findings suggest that increased fibrinolysis in the gastrointestinal mucosa may play an important role in enhancing mucosal permeability to plasma proteins.
D000328:Adult; D005342:Fibrinolysis; D005753:Gastric Mucosa / Q000503:physiopathology; D006801:Humans; D008297:Male; D010960:Plasminogen Activators / Q000378:metabolism*; D011504:Protein-Losing Enteropathies / Q000188:drug therapy / Q000209:etiology*; D014148:Tranexamic Acid / Q000627:therapeutic use
D014148:Tranexamic Acid; D010960:Plasminogen Activators