[The activity of the dehydrogenases of the tricarboxylic acid cycle and concentration of adenylic nucleotides in the brain and liver in experimental hypothyroidism].
A determination was made of the activity of the cycle of tricarbolic acids of dehydrogenases and of the content of adeninnucleotides in the brain and the liver of rats in experimental hypothyroidism caused by mercasolyl administration. There were revealed deviations in the activity of dehydrogenases, more pronounced in the liver. Adeninnucleotide content was found to be reduced only in the brain. ATP/ADP ratio decreased in both tissues. The data obtained are discussed with consideration to the possibility of allosteric regulation of the enzyme activity and peculiarities attending the metabolism of substances in the tissues under study.
D000227:Adenine Nucleotides / Q000378:metabolism*; D000818:Animals; D007037:Hypothyroidism / Q000201:enzymology / Q000378:metabolism*; D007521:Isocitrate Dehydrogenase / Q000378:metabolism; D007655:Ketoglutarate Dehydrogenase Complex / Q000378:metabolism; D008099:Liver / Q000378:metabolism*; D008291:Malate Dehydrogenase / Q000378:metabolism; D008297:Male; D008928:Mitochondria / Q000201:enzymology; D009247:NADH, NADPH Oxidoreductases / Q000378:metabolism; D010088:Oxidoreductases / Q000378:metabolism*; D011768:Pyruvate Dehydrogenase Complex / Q000378:metabolism; D051381:Rats; D013385:Succinate Dehydrogenase / Q000378:metabolism
D000227:Adenine Nucleotides; D011768:Pyruvate Dehydrogenase Complex; D010088:Oxidoreductases; D008291:Malate Dehydrogenase; D007521:Isocitrate Dehydrogenase; D007655:Ketoglutarate Dehydrogenase Complex; D013385:Succinate Dehydrogenase; D009247:NADH, NADPH Oxidoreductases
Aktivnost' degidrogenaz tsikla trikarbonovykh kislot i soderzhanie adenilovykh nukleotidov v golovnom mozge i pecheni pri éksperimental'nom gipotireoze