[Behavior of serum gastrin under vagus stimulation with 2-deoxy-D-glucose with special reference to acid secretion and the mucosal histology].
Administration of 2-DG accompanied by simultaneous neutralization of gastric contents with sodium bicarbonate resulted in a rise in serum gastrin in 4 patients without gastric disease, 4 with duodenal ulcer and 4 with gastric ulcer. The rise in gastrin equals that observed on stimulation with meat extract. Patients with gastric ulcers display a low PAO and a small rise in gastrin compared with normals and patients with duodenal ulcers. This finding correlates well with the chronic atrophic changes of the antral mucosa in patients with gastric ulcer.
D001639:Bicarbonates; D003837:Deoxy Sugars / Q000494:pharmacology*; D003847:Deoxyglucose / Q000494:pharmacology*; D004381:Duodenal Ulcer / Q000378:metabolism; D005750:Gastric Juice / Q000378:metabolism*; D005753:Gastric Mucosa / Q000187:drug effects* / Q000473:pathology; D005755:Gastrins / Q000097:blood*; D010437:Peptic Ulcer / Q000378:metabolism; D012964:Sodium
D001639:Bicarbonates; D003837:Deoxy Sugars; D005755:Gastrins; D003847:Deoxyglucose; D012964:Sodium
Verhalten von Serumgastrin bei vagaler Stimulierung mit 2-Desoxy-D-Glucose unter Berücksichtigung der Säuresekretion und der Schleimhauthistologie