Distribution and behavior of isoselenouronium salts in the body. VI. Comparative study of distribution and radioprotectivity of selenium derivatives.
The protective effect of AESe, 2-ASe, and Se-MEG during irradiation with a dose rate of 500 R/min was followed. The protective effect of 2-ASe is substantially lower during the dose rate of 20 R/min and even during an increased dose. AESe and Se-MEG are noneffective. The time of duration of the protective effect of 2-ASe corresponds to the period of its high concentration in the organism after the administration, i.e. ca. 45 min.
D000818:Animals; D004305:Dose-Response Relationship, Drug; D004307:Dose-Response Relationship, Radiation; D007550:Isothiuronium / Q000031:analogs & derivatives* / Q000378:metabolism; D007928:Lethal Dose 50; D008297:Male; D051379:Mice; D011833:Radiation Injuries, Experimental / Q000517:prevention & control*; D011837:Radiation-Protective Agents / Q000378:metabolism*; D012643:Selenium; D013890:Thiourea / Q000031:analogs & derivatives*; D013997:Time Factors
D011837:Radiation-Protective Agents; D007550:Isothiuronium; D013890:Thiourea; D012643:Selenium