[Intraerythrocytic enzyme activities in euthyroid subjects and hyperthyroid patients before treatment and following stabilization of metabolism using radioiodine therapy].
The activities of six intra-erythrocytic enzymes--glucose-6-phosphate-dehydrogenase, aldolase, pyruvate kinase, hexokinase, triosephosphate-isomerase and phosphoglucomutase--have been measured in euthyroid probands (n=18) and in hyperthyroid patients (n=13) prior to radioiodine therapy and after stabilization of the metabolic conditions. The hexokinase, triosephosphate-isomerase, pyruvate kinase, and glucose-6-phosphate-dehydrogenase did not show any significant changes. A moderate diminution of the aldolase activity and a distinct decrease of the phosphoglucomutase activity occur during hyperthyroidism. After normalization of the metabolic conditions, both the enzymatic activities increase again.
D004912:Erythrocytes / Q000201:enzymology*; D005634:Fructose-Bisphosphate Aldolase / Q000097:blood; D005954:Glucosephosphate Dehydrogenase / Q000097:blood; D006801:Humans; D006980:Hyperthyroidism / Q000201:enzymology* / Q000532:radiotherapy; D007457:Iodine Radioisotopes / Q000627:therapeutic use; D010733:Phosphoglucomutase / Q000097:blood; D011770:Pyruvate Kinase / Q000097:blood; D014305:Triose-Phosphate Isomerase / Q000097:blood
D007457:Iodine Radioisotopes; D005954:Glucosephosphate Dehydrogenase; D011770:Pyruvate Kinase; D005634:Fructose-Bisphosphate Aldolase; D014305:Triose-Phosphate Isomerase; D010733:Phosphoglucomutase
Intraerythrozytäre Enzymaktivitäten bei euthyreoten Probanden und hyperthyreoten Patienten vor Behandlung und nach Stabilisierung der Stoffwechsellage durch Radiojodtherapie