[Study of the dynamics of n-propyl alcohol in an Act. erythreus culture during the biosynthesis of erythromycin using a gas-liquid chromatographic method].
The effect of n-propyl alcohol on biosynthesis of erythromycin and the dynamics of the precursor consumption were studied with the method of gas-liquid chromatography. It was shown that neither the optimal concentration of the precursor, nor its stimulating effect on different media correlated. n-Propyl alcohol was used not only for the antibiotic biosynthesis but also according to other metabolic path-ways and in addition its evaporation from the medium was registered. During the first period of the fermentation n-propyl alcohol suppressed the antibiotic biosynthesis.
D000433:1-Propanol / Q000032:analysis / Q000378:metabolism*; D000332:Aerobiosis; D002849:Chromatography, Gas / Q000379:methods*; D002853:Chromatography, Liquid / Q000379:methods*; D003470:Culture Media; D004305:Dose-Response Relationship, Drug; D004917:Erythromycin / Q000096:biosynthesis*; D012996:Solutions; D013242:Sterilization; D013302:Streptomyces / Q000378:metabolism*
D003470:Culture Media; D012996:Solutions; D004917:Erythromycin; D000433:1-Propanol
Issledovanie dinamiki potrebleniia n-propilovogo spirta v kul'ture Act. erythreus pri biosinteze éritromitsina metodom gazozhidkostnoĭ khromatografii