A functional description of the canine choledochoduodenal flutter valve.
Forward- and reverse-opening pressures of the choledochoduodenal junction were measured in anesthetized, vagotomized dogs. Mean reverse-opening pressures were found to be significantly greater in most cases including those following the intraductal administration of vasoactive agents which are known to significantly influence mean forward-opening pressures. The polypeptides CCK-PZ and CCK-C8 were ineffective in reducing mean forward-opening pressures regardless of the route of administration. Previously published observations have indicated that mean forward-opening pressures are also unaffected by nervous activity. It is concluded that the canine choledochoduodenal junction possesses the physical and functional properties of a passive flutter valve during duodenal relaxation.
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D002766:Cholecystokinin / Q000494:pharmacology; D003135:Common Bile Duct / Q000187:drug effects / Q000502:physiology*; D004285:Dogs; D004386:Duodenum / Q000502:physiology*; D004837:Epinephrine / Q000494:pharmacology; D005260:Female; D005769:Gastrointestinal Motility / Q000187:drug effects; D006632:Histamine / Q000494:pharmacology; D006874:Hydrostatic Pressure; D007583:Jejunum / Q000187:drug effects; D008297:Male; D008688:Methacholine Compounds / Q000494:pharmacology; D009119:Muscle Contraction / Q000187:drug effects
D008688:Methacholine Compounds; D006632:Histamine; D002766:Cholecystokinin; D004837:Epinephrine