A preliminary experiment on regression of human ovarian tumor transplants in athymic nude mice following a single exposure to 60Co radiation.
Human ovarian tumour transplants (AN-LE) are grown in the thymus defective nude mouse mutant (nu/nu BALB/c/A/Bom). Procedures for local irradiation of the tumors with 60Co-radiation are described. An introductory test of the usefulness of these transplants in studies of radiation effects on human tumors is performed by investigation of the time course of regression of AN-LE transplants in 6 mice, following single exposures to 375, 750 1 180, and 1 575 rad, respectively.
D000230:Adenocarcinoma / Q000532:radiotherapy*; D000818:Animals; D003037:Cobalt Radioisotopes; D005260:Female; D051379:Mice; D008819:Mice, Nude; D009368:Neoplasm Transplantation; D010051:Ovarian Neoplasms / Q000532:radiotherapy*; D013950:Thymus Gland / Q000002:abnormalities
D003037:Cobalt Radioisotopes