title: Activity of sympathetic nerves in heart during cardiopulmonary bypass in patients.
abstract: The sympathetic nerve activity in heart during cardiopulmonary bypass was studied in 20 patients. The rate of release of dopamine-beta-hydroxylase from cardiac nerves was used as an indicator. It was found that the thoracotomy alone does not represent such a stimulus which would lead unambiguously to sympathetic overactivity in heart. Cardiopulmonary bypass represents, on the other hand, an intensive sympathomimetic stimulus, as it was demonstrated by significnat increase of coronary A-V difference negativity of dopamine-beta-hydroxylase as early in 15th minute of its duration. The washout of enzyme to the end of 30 min. duration of bypass still increased. After finishing of bypass the coronary A-V diff. of dopamine-beta-hydroxylase again decreased.
mesh_terms: D002315:Cardiopulmonary Bypass; D004299:Dopamine beta-Hydroxylase / Q000378:metabolism; D005112:Extracorporeal Circulation; D005260:Female; D006321:Heart / Q000294:innervation*; D006801:Humans; D008297:Male; D013564:Sympathetic Nervous System / Q000503:physiopathology*; D013903:Thoracic Surgery; D013909:Thorax / Q000601:surgery; D013997:Time Factors
chemical_list: D004299:Dopamine beta-Hydroxylase