[Effect of retabolil and thyrocalcitonin on mineral metabolism in the bones of rats following a fracture of the lower jaw].
In tests conducted with 65 male-rats of the Wistar line, aged 2-3 months subject to studies was the effect of retabolil (RB) and thyrocalcitonine (TCT) on the mineral metabolism in the osseous tissue following fracture of the lower jaw. The per cent of the Ca45 isotope incorporation in the injured and unaffected (contralateral) sections of the jaw and also in the thigh bones, lying far away from the site of the injury, was determined in dynamics. The agents RB and TCT, displaying different modes of action, produce a similarly oriented effect, viz. accelerated mineralization of the osseous tissue, which is evident from an increased incorporation of the Ca45 isotope in the fracture area during the first post-traumatic week, followed by declining incorporation on the 14-28th day.
D000818:Animals; D001861:Bone Regeneration / Q000187:drug effects; D001842:Bone and Bones / Q000187:drug effects; D002113:Calcification, Physiologic / Q000187:drug effects*; D002116:Calcitonin / Q000494:pharmacology*; D002132:Calcium Radioisotopes; D004963:Estrenes / Q000494:pharmacology*; D008297:Male; D008337:Mandibular Fractures / Q000188:drug therapy* / Q000378:metabolism; D051381:Rats
D002132:Calcium Radioisotopes; D004963:Estrenes; D002116:Calcitonin
Vliianie retabolila i tirokal'tsitonina na mineral'nyi obmen v kostiakh krys posle pereloma nizhneĭ cheliusti