Lipogenesis in muscle, liver, and adipose tissue of normal and dystrophic chickens.
The in vitro rate of oxidation and incorporation of [U-14C]glucose into lipids of muscle, liver, and adipose tissue of dystrophic and control chickens at 1 week, 1, 6, and 12 months of age were determined. The muscle and liver from dystrophic birds showed a high rate of [U-14C]glucose oxidation and incorporation into lipids during 1 week, 6 and 12 months. Insulin did not have any consistent stimulatory effect in all the tissues on the rate of glucose oxidation and incorporation into lipids. The contributory role played by the liver in the accumulation of lipids in dystrophic muscle is discussed.
D000273:Adipose Tissue / Q000187:drug effects / Q000254:growth & development / Q000378:metabolism*; D000375:Aging; D000818:Animals; D002645:Chickens; D005947:Glucose / Q000378:metabolism; D007328:Insulin / Q000494:pharmacology; D008055:Lipids / Q000096:biosynthesis*; D008099:Liver / Q000187:drug effects / Q000254:growth & development / Q000378:metabolism*; D024510:Muscle Development; D009132:Muscles / Q000187:drug effects / Q000378:metabolism*; D009137:Muscular Dystrophy, Animal / Q000378:metabolism*
D007328:Insulin; D008055:Lipids; D005947:Glucose