[Blood concentration and urinary excretion in human of OE-7, a gastric hard capsule containing enteric-coated granules. I  (author's transl)].
The investigation of physico-chemical properties and measurement of blood concentration and amount of excretion into urine in human of OE-7 (main constituent is erythromycin stearate) were performed as the fundamental studies. The results obtained were as follows; i) OE-7 is a gastric hard capsule containing enteric coated granules. ii) The contents of OE-7 capsule (granules) were resistant to acid and was favarable in the enteric solubility. iii) In comparison with the conventional erythromycin stearate capsule in healthy adults, OE-7 showed a relatively small individual difference in blood concentration after administration. iv) OE-7 was higher in the mean blood concentration and was superior in the persistence of effective blood concentration compared with the conventional erythromycin stearate capsules.
D000328:Adult; D002214:Capsules; D004355:Drug Stability; D004917:Erythromycin / Q000008:administration & dosage / Q000378:metabolism*; D006801:Humans; D008297:Male; D013608:Tablets, Enteric-Coated
D002214:Capsules; D013608:Tablets, Enteric-Coated; D004917:Erythromycin