Aspirin and exercise-induced asthma.
In four subjects with exercise-induced asthma, aspirin and placebo were administered prior to exercise in a double blind study. Pulmonary function tests did not reveal any difference between the response after aspirin or placebo. We conclude that in these four subjects aspirin did not prevent the bronchoconstrictor response. This might suggest that prostaglandins have no significant role in exercise-induced asthma.
D000328:Adult; D000403:Airway Resistance / Q000187:drug effects; D001241:Aspirin / Q000494:pharmacology / Q000627:therapeutic use*; D001249:Asthma / Q000188:drug therapy* / Q000209:etiology; D005541:Forced Expiratory Volume; D006801:Humans; D008449:Maximal Expiratory Flow-Volume Curves; D005082:Physical Exertion; D010919:Placebos; D011453:Prostaglandins / Q000378:metabolism; D014797:Vital Capacity
D010919:Placebos; D011453:Prostaglandins; D001241:Aspirin