title: Development of gonadotrophin-binding sites in the immature rat ovary.
abstract: There was a temporal relationship between ovarian development and the sites to which 125I-labelled gonadotrophins became bound. Labelled human LH and FSH bound uniformly to 5- and 15-day-old ovaries. At 21 days, heavy FSH and light LH binding was observed over the granulosa cells increased at Day 33 and again at Day 38. Quantitative determination by gamma-ray spectrophotometry of binding to ovarian sections showed that LH binding gradually increased with advancing age, but FSH binding remained relatively constant between Days 5 and 33 with a significant increase between Days 33 and 38.
mesh_terms: D000367:Age Factors; D000818:Animals; D001665:Binding Sites; D005260:Female; D005640:Follicle Stimulating Hormone / Q000378:metabolism*; D006107:Granulosa Cells / Q000378:metabolism; D007986:Luteinizing Hormone / Q000378:metabolism*; D010053:Ovary / Q000254:growth & development* / Q000378:metabolism; D051381:Rats
chemical_list: D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone