Effect of 10 days reserpine or apomorphine administration on sleep cycles in rats.
The duration of sleep-wakefulness periods and sleep cycles was investigated by means of EEG and EMG in rats with implanted brain electrodes and myographic electrodes in neck muscles during 5 hr trials after repeated administration of 2 depressant drugs, reserpine and apomorphine. Ten days administration of reserpine at a dose of 0.05 mg/day, SC, decreased the duration of both slow-wave and paradoxical sleep, whereas apomorphine had no effect on sleep duration or occurance of sleep phases in either the low dose (0.2 mg/kg/day, SC) or in the high dose of 0.6 mg/kg/day, SC. This finding might be correlated with previously found differences in catecholamine levels in the brain in the same model experiments.
D000818:Animals; D001058:Apomorphine / Q000494:pharmacology*; D001921:Brain / Q000502:physiology; D004569:Electroencephalography; D004576:Electromyography; D008297:Male; D009132:Muscles / Q000502:physiology; D051381:Rats; D012110:Reserpine / Q000494:pharmacology*; D012894:Sleep Stages / Q000187:drug effects*; D013997:Time Factors; D014851:Wakefulness / Q000187:drug effects
D012110:Reserpine; D001058:Apomorphine