title: Reversal of systemic manifestations of cryoglobulinemia. Treatment with melphalan and prednisone.
abstract: In a patient with essential cryoglobulinemia with systemic, cutaneous, and neurologic manifestations and a mixed IgG-IgM cryoprotein, elimination of systemic and cutaneous disease manifestations, as well as notable reversal of neurologic impairment, followed therapy with melphalan. Levels of circulating cryoprotein decreased, but protein structure was unchanged by chemotherapy. Experience to date with alkylating agents suggests that this mode of treatment is the most effective currently available.
mesh_terms: D003450:Cryoglobulins; D005260:Female; D006801:Humans; D007074:Immunoglobulin G / Q000032:analysis*; D007075:Immunoglobulin M / Q000032:analysis*; D008558:Melphalan / Q000627:therapeutic use*; D008875:Middle Aged; D009461:Neurologic Manifestations; D010265:Paraproteinemias / Q000188:drug therapy*; D011241:Prednisone / Q000627:therapeutic use*; D012075:Remission, Spontaneous; D012877:Skin Manifestations
chemical_list: D003450:Cryoglobulins; D007074:Immunoglobulin G; D007075:Immunoglobulin M; D008558:Melphalan; D011241:Prednisone