Effects of glutamate and sulphur containing amino acids on ammonia toxicity and methionine sulphoximine convulsions in mice.
Arginine and large doses of glutamate (greater than 500 mg/kg) were found to reduce ammonia toxicity transiently in mice. Smaller doses of glutamate (greater than or equal to 200 mg/kg) were effective when administered with glucose. Cysteic acid, homocysteine and methionine, but not taurine reduced ammonia toxicity. All 4 amino acids reduced the number of convulsions induced by methionine sulphoximine. It is proposed that taurine has a general anticonvulsant action and that cysteic acid, homocysteine and methionine may have a specific effect on the action of ammonia on the central nervous system.
D000603:Amino Acids, Sulfur / Q000627:therapeutic use*; D000818:Animals; D000927:Anticonvulsants; D001120:Arginine / Q000627:therapeutic use; D003540:Cystathionine / Q000627:therapeutic use; D003544:Cysteic Acid / Q000627:therapeutic use; D005971:Glutamates / Q000627:therapeutic use*; D006710:Homocysteine / Q000627:therapeutic use; D008297:Male; D008715:Methionine / Q000627:therapeutic use; D008717:Methionine Sulfoximine; D051379:Mice; D000644:Quaternary Ammonium Compounds / Q000037:antagonists & inhibitors / Q000506:poisoning*; D012640:Seizures / Q000139:chemically induced / Q000517:prevention & control*; D013654:Taurine / Q000627:therapeutic use
D000603:Amino Acids, Sulfur; D000927:Anticonvulsants; D005971:Glutamates; D000644:Quaternary Ammonium Compounds; D006710:Homocysteine; D008717:Methionine Sulfoximine; D013654:Taurine; D003540:Cystathionine; D001120:Arginine; D003544:Cysteic Acid; D008715:Methionine