[The therapeutic effect of aprotinin inhalations in influenza and paramyxovirus infections in mice].
Mice infected with influenza A/Aichi/2/68 (H3N2) virus or Sendai/960 paramyxovirus were treated by inhalations of aerosol aprotinin, a broad spectrum inhibitor of proteinases. A course of inhalations of finely dispersed aerosol aprotinin including 4 exposures of 35-40 min each daily for 6 days provided respiratory administration of aprotinin in a dose about 100 kallikrein-inhibiting U/mouse per day. In mice treated by aprotinin inhalations, histological examinations showed decreased pulmonary pathology, and their body weights increased as much as in uninfected animals. In the placebo group, the weight decreased until the death of the animals. The protective effect of aprotinin inhalations was 40-80% with inoculation doses 10-100 MLD50/mouse. The treated animals died 2-4 days later than those in the placebo group. The results indicate the expedience of inhalation therapy with aerosol aprotinin in influenza and paramyxovirus respiratory infections.
D000280:Administration, Inhalation; D000818:Animals; D007611:Aprotinin / Q000008:administration & dosage*; D001835:Body Weight / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D004353:Drug Evaluation, Preclinical; D009980:Influenza A virus; D008168:Lung / Q000187:drug effects / Q000473:pathology; D051379:Mice; D009976:Orthomyxoviridae Infections / Q000188:drug therapy* / Q000473:pathology; D010222:Parainfluenza Virus 1, Human; D018184:Paramyxoviridae Infections / Q000188:drug therapy* / Q000473:pathology
D007611:Aprotinin
Lechebnyĭ éffekt ingaliatsiĭ aprotinina pri grippoznoĭ i paramiksovirusnoĭ infektsiiakh u mysheĭ.