Analgesia mediated by a direct spinal action of narcotics.
Narcotic analgetics administered directly into the spinal subarachnoid space of the rat via a chronically inserted catheter produce a potent analgesia that can be antagonized by naloxone. The narcotics, acting only at the spinal level, changed cord function to block not only spinal reflexes but also the operant response to painful stimuli.
D000698:Analgesia; D000818:Animals; D003061:Codeine / Q000494:pharmacology; D009020:Morphine / Q000494:pharmacology; D009022:Morphine Derivatives / Q000494:pharmacology; D009270:Naloxone / Q000494:pharmacology; D009294:Narcotics / Q000008:administration & dosage / Q000494:pharmacology*; D010146:Pain / Q000188:drug therapy; D051381:Rats; D012018:Reflex / Q000187:drug effects*; D013116:Spinal Cord / Q000187:drug effects*; D013376:Substantia Gelatinosa / Q000187:drug effects
D009022:Morphine Derivatives; D009294:Narcotics; D009270:Naloxone; D009020:Morphine; D003061:Codeine