Effect of nilvadipine on balloon catheterization-induced intimal thickening of the coronary artery in miniature pigs.
The effect of nilvadipine on balloon catheterization-induced intimal thickening of the coronary artery was examined in miniature pigs. A diffuse intimal thickening was observed in vehicle-treated controls 6 weeks after balloon catheterization. The histologic features of the intimal thickening resembled those of early atherosclerotic lesions and restenosis after percutaneous transluminal coronary angioplasty (PTCA). Nilvadipine given in a daily dose of 10 mg/kg (subcutaneously, s.c.) for 6 weeks significantly inhibited intimal thickening. The ratio of the cross-sectional area of the intima to the cross-sectional area of the media was significantly reduced by 62% in nilvadipine-treated animals. These results suggest that nilvadipine may prevent or exert beneficial effects on coronary arterial injuries such as atherosclerosis and restenosis after PTCA.
D015906:Angioplasty, Balloon, Coronary; D000818:Animals; D002121:Calcium Channel Blockers / Q000494:pharmacology*; D002404:Catheterization / Q000009:adverse effects*; D003324:Coronary Artery Disease / Q000473:pathology*; D003331:Coronary Vessels / Q000187:drug effects* / Q000473:pathology; D004730:Endothelium, Vascular / Q000187:drug effects / Q000473:pathology*; D005260:Female; D009543:Nifedipine / Q000031:analogs & derivatives* / Q000494:pharmacology; D013552:Swine; D013556:Swine, Miniature
D002121:Calcium Channel Blockers; C035100:nilvadipine; D009543:Nifedipine