Representation of cutaneous afferents by fluoride-resistant acid phosphatase (FRAP)-active terminals in the rat substantia gelatinosa rolandi.
While transection of the sciatic nerve results in a complete ipsilateral extinction of FRAP activity in respective segments of the rat spinal cord, cutaneous denervation of the hind leg induces a patchy disappearance of this same enzyme in the Rolando substance. The possible participation of FRAP in metabolism of the primary sensory transmitter substance, its relation to substance P and its involvement in gating mechanisms are discussed.
D000135:Acid Phosphatase / Q000378:metabolism*; D000818:Animals; D003714:Denervation; D005260:Female; D008297:Male; D009411:Nerve Endings / Q000201:enzymology; D009474:Neurons / Q000201:enzymology*; D009475:Neurons, Afferent / Q000201:enzymology*; D051381:Rats; D012584:Sciatic Nerve / Q000502:physiology; D013116:Spinal Cord / Q000201:enzymology*; D013376:Substantia Gelatinosa / Q000201:enzymology*
D000135:Acid Phosphatase