[Inhibition of the reproduction of the influenza B virus by aprotinin].
Injection of aprotinin, a natural inhibitor of proteinases, into the allantoic cavity of chick embryos infected with influenza B/Lee/40 or B/HK/73 virus resulted in inhibition of proteolytic cleavage of virus hemagglutinin HA into HA1 and HA2, thereby decreasing the level of proteolytic activation of the synthesized virus particles. As a result of this inhibition in aprotinin-treated embryos, multicycle virus reproduction was limited and virus yields decreased considerably. The experimental results indicate the potential of chemotherapeutic inhibition of infection caused by influenza B viruses using antiproteinase agents interfering with proteolytic activation of virions.
D000818:Animals; D007611:Aprotinin / Q000494:pharmacology*; D002642:Chick Embryo; D003864:Depression, Chemical; D004591:Electrophoresis, Polyacrylamide Gel; D009981:Influenza B virus / Q000737:chemistry / Q000187:drug effects* / Q000472:pathogenicity / Q000502:physiology; D051379:Mice; D010455:Peptides / Q000032:analysis; D012692:Serial Passage; D014779:Virus Replication / Q000187:drug effects*
D010455:Peptides; D007611:Aprotinin
Ingibirovanie reproduktsii virusa grippa B aprotininom.