title: Concerning the ionic basis of presynaptic inhibition.
abstract: The superfused rat cuneate nucleus has been used to investigate the sensitivity of primary afferent terminals and of evoked primary afferent depolarization (PAD) to alterations in extracellular K+ and Cl- ions levels. Results indicate that PAD is caused by an efflux of Cl- from primary afferent terminals rather than by an increase in extracellular K+.
mesh_terms: D000818:Animals; D002712:Chlorides / Q000494:pharmacology*; D003214:Conditioning, Classical; D004558:Electric Stimulation; D008475:Median Nerve / Q000502:physiology; D008526:Medulla Oblongata / Q000187:drug effects / Q000502:physiology*; D009475:Neurons, Afferent / Q000187:drug effects / Q000502:physiology; D010477:Perfusion; D011188:Potassium / Q000494:pharmacology*; D051381:Rats; D013569:Synapses / Q000187:drug effects / Q000502:physiology
chemical_list: D002712:Chlorides; D011188:Potassium