title: The clearance of antipyrine and indocyanine green in normal subjects and in patients with chronic lever disease.
abstract: The pharmacokinetics after oral administration of 1,200 mg antipyrine and intravenous administration of 0.5 mg/kg indocyanine green have been investigated in 6 normal subjects and in 20 patients with chronic liver disease of varying etiology. Severe impairment of liver function associated with a decrease in serum albumin, elevation in serum bilirubin, or prolongation in prothrombin time correlated with a fall in the clearance of both drugs. The clearance of the two drugs correlated well in normal subjects and in patients with chronic liver disease. The presence of a surgical portacaval anastomosis was associated with a lower indocyanine green clearance for comparable clearance of antipyrine. The concept of functioning hepatic parenchymal mass is proposed as a common rate-limiting parameter for the elimination of the two drugs.
mesh_terms: D000328:Adult; D000368:Aged; D000983:Antipyrine / Q000378:metabolism*; D001663:Bilirubin / Q000097:blood; D002908:Chronic Disease; D005260:Female; D006207:Half-Life; D006801:Humans; D007208:Indocyanine Green / Q000378:metabolism*; D007700:Kinetics; D008107:Liver Diseases / Q000378:metabolism*; D008297:Male; D008657:Metabolic Clearance Rate; D008875:Middle Aged; D011517:Prothrombin Time; D012709:Serum Albumin / Q000378:metabolism
chemical_list: D012709:Serum Albumin; D007208:Indocyanine Green; D001663:Bilirubin; D000983:Antipyrine