Evidence for a dopamine sensitive receptor in the young rat aorta.
Dopamine caused relaxation in young rat but not old rat aortae contracted with prostaglandin F2 alpha. The antagonizing action of propranolol was less effective on the relaxing effect of dopamine than that of isoproterenol or norepinephrine. Chlorpromazine or haloperidol abolished the relaxing effect of dopamine but only reduced the effect of norepinephrine and isoproterenol. The relaxing effect of dopamine is mainly mediated by the activation of dopamine sensitive receptors.
D000818:Animals; D001013:Aorta, Thoracic / Q000502:physiology*; D002746:Chlorpromazine / Q000494:pharmacology; D004298:Dopamine / Q000494:pharmacology / Q000502:physiology*; D006220:Haloperidol / Q000494:pharmacology; D066298:In Vitro Techniques; D007545:Isoproterenol / Q000494:pharmacology; D008297:Male; D009119:Muscle Contraction / Q000187:drug effects; D009130:Muscle, Smooth / Q000187:drug effects; D009638:Norepinephrine / Q000494:pharmacology; D051381:Rats; D011955:Receptors, Drug / Q000187:drug effects*; D013268:Stimulation, Chemical
D011955:Receptors, Drug; D006220:Haloperidol; D007545:Isoproterenol; D002746:Chlorpromazine; D004298:Dopamine; D009638:Norepinephrine