title: Experimental respiratory disease in dogs due to Bordetella bronchiseptica.
abstract: Young dogs of two age groups, six weeks and 12 weeks respectively, were infected by aerosol with a strain of Bordetella bronchiseptica which had been isolated from a dog with pneumonia. Clinical respiratory disease characterised by coughing and in some cases purulent nasal discharge was induced in both groups of infected dogs and also in dogs kept in contact. B bronchiseptica was recovered from the nasal cavity, trachea, bronchi and lung parenchyma of infected and contact animals. At necropsy, masses of Gram-negative bacteria were found trapped in the cilia of the respiratory epithelia and there was an exudate containing neutrophils in the mucosae of the respiratory tract at all levels. A close similarity was noted between the lesions produced in the dog and those described in pertussis infection in man. Experimental respiratory disease in the dog due to B bronchiseptica may offer a model system for the study of the human disease.
mesh_terms: D000818:Animals; D001884:Bordetella / Q000302:isolation & purification; D001885:Bordetella Infections / Q000382:microbiology / Q000473:pathology / Q000662:veterinary*; D003371:Cough / Q000662:veterinary; D004283:Dog Diseases / Q000382:microbiology / Q000473:pathology; D004285:Dogs; D008168:Lung / Q000473:pathology; D009297:Nasal Mucosa / Q000378:metabolism / Q000473:pathology; D012141:Respiratory Tract Infections / Q000382:microbiology / Q000473:pathology / Q000662:veterinary*