Recurrent prostate cancer despite undetectable prostate specific antigen.
Serum prostate specific antigen (PSA) is a sensitive tumor marker following definitive therapy for adenocarcinoma of the prostate. Detectable levels of PSA after radical prostatectomy indicate residual and/or recurrent cancer. Therefore, we were surprised to document recurrent cancer following radical retropubic prostatectomy in a man who had undetectable serum PSA levels. This observation suggests that careful clinical monitoring remains essential after definitive therapy, since rare patients may have recurrent and/or residual carcinoma despite undetectable levels of PSA.
D000230:Adenocarcinoma / Q000175:diagnosis / Q000601:surgery*; D000368:Aged; D014408:Biomarkers, Tumor / Q000097:blood*; D005188:False Negative Reactions; D006801:Humans; D008297:Male; D009364:Neoplasm Recurrence, Local / Q000175:diagnosis*; D017430:Prostate-Specific Antigen / Q000097:blood*; D011471:Prostatic Neoplasms / Q000175:diagnosis / Q000601:surgery*
D014408:Biomarkers, Tumor; D017430:Prostate-Specific Antigen