Specificity of neural effect on renal tubular sodium reabsorption.
Low level direct renal nerve stimulation increases renal tubular sodium reabsorption in the absence of changes in glomerular filtration rate, renal blood flow, or intrarenal distribution of blood flow. Blockade of this response with phenoxybenzamine (or guanethidine) supports the interpretation that it is mediated by direct adrenergic innervation of the renal tubule.
D000818:Animals; D004285:Dogs; D005260:Female; D007684:Kidney Tubules / Q000378:metabolism*; D009318:Natriuresis / Q000187:drug effects; D010643:Phenoxybenzamine / Q000494:pharmacology; D012039:Regional Blood Flow; D013564:Sympathetic Nervous System / Q000502:physiology
D010643:Phenoxybenzamine