Experimentally induced steroid atrophy in the domestic pig and man.
A histological method of ranking topical steroid preparations according to the degree of epidermal thinning they cause in pig skin has been shown to be applicable to human skin. A 0-05% ointment of the new compound, clobetasone butyrate (Molivate), has been shown to cause less thinning than either fluocinolone acetonide 0-025% (Synalar) or flurandrenolone 0-0125% (Haelan) when applied without the use of occlusive dressings for 3 weeks to the human forearm.
D000328:Adult; D000818:Animals; D001284:Atrophy / Q000139:chemically induced; D005446:Fluocinolone Acetonide / Q000494:pharmacology*; D005478:Flurandrenolone / Q000494:pharmacology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D012867:Skin / Q000187:drug effects / Q000473:pathology; D013552:Swine
D005446:Fluocinolone Acetonide; D005478:Flurandrenolone