title: Stoffwechselprodukte von mikroorganismen. 154. Mitteilung. Nikkomycin, ein neuer hemmstoff der chitinsynthese bei pilzen.
abstract: From the fermentation broth of Streptomyces tendae Tü 901 a substance was isolated which inhibits the growth of several fungi. The new antibiotic affects the chitchin biosynthesis. Its structure was identified by mass spectrometry of the products obtained after chemical degradation. Nikkomycin is a nucleoside-peptide antibiotic consisting of uracil, an amino hexuronic acid and a new amino acid containing a pyridin ring.
mesh_terms: D000617:Aminoglycosides; D000935:Antifungal Agents / Q000032:analysis* / Q000494:pharmacology; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D002686:Chitin / Q000037:antagonists & inhibitors* / Q000096:biosynthesis; D004355:Drug Stability; D005656:Fungal Proteins / Q000096:biosynthesis; D008826:Microbial Sensitivity Tests; D008968:Molecular Conformation; D009089:Mucor / Q000187:drug effects; D009696:Nucleic Acids / Q000096:biosynthesis; D009705:Nucleosides / Q000032:analysis / Q000494:pharmacology; D013057:Spectrum Analysis; D013302:Streptomyces / Q000378:metabolism*
chemical_list: D000617:Aminoglycosides; D000935:Antifungal Agents; D005656:Fungal Proteins; D009696:Nucleic Acids; D009705:Nucleosides; D002686:Chitin; C011952:nikkomycin