Is beta-(4-chlorophenyl)-GABA a specific antagonist of substance P on cerebral cortical neurons?
Beta-(4-chlorophenyl)-GABA (Baclofen, Lioresal) antagonized the excitant actions of acetylcholine and substance P to comparable extents. L-glutamate-induced excitation was affected to a lesser extent. These findings do not support the suggestion that beta-(4-chlorophenyl)-GABA is a specific substance P antagonist.
D000109:Acetylcholine / Q000037:antagonists & inhibitors; D000200:Action Potentials / Q000187:drug effects; D000613:Aminobutyrates / Q000494:pharmacology*; D000818:Animals; D001418:Baclofen / Q000494:pharmacology*; D002540:Cerebral Cortex / Q000187:drug effects* / Q000502:physiology; D005971:Glutamates / Q000494:pharmacology; D008297:Male; D009474:Neurons / Q000187:drug effects / Q000502:physiology; D011712:Pyramidal Tracts / Q000502:physiology; D051381:Rats; D013268:Stimulation, Chemical; D013373:Substance P / Q000037:antagonists & inhibitors*
D000613:Aminobutyrates; D005971:Glutamates; D013373:Substance P; D001418:Baclofen; D000109:Acetylcholine