title: Circadian rhythms in gonadotropin excretion in prepubertal and pubertal children.
abstract: Timed urinary collections were obtained during sleep and waking hours from 27 prepubertal children ranging in age from 2-12 years and from 13 subjects in various stages of puberty, 12-18 years old. The urine samples were extracted with acetone and introduced into FSH and LH radioimmunoassays. Results of the study indicate a significant nocturnal augmentation of LH secretion in pubertal subjects, confirming existing reports using blood sampling techniques. Increased LH and FSH excretion during sleep was also found in prepubertal children.
mesh_terms: D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D002940:Circadian Rhythm; D005260:Female; D005640:Follicle Stimulating Hormone / Q000652:urine*; D006801:Humans; D007986:Luteinizing Hormone / Q000652:urine*; D008297:Male; D011627:Puberty; D012890:Sleep
chemical_list: D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone