Hyperphagia and increased growth in rats after intraventricular injection of 5,7-dihydroxytryptamine.
Juvenile male rats given intracerebroventricular injections of 5,7-dihydroxytryptamine, following treatment with desmethylimipramine, maintained body weight gains of 5 to 6 grams per day into adulthood and grew much larger than control rats. Biochemical analyses of brain tissue obtained 50 to 140 days after the injections revealed 60 to 86% depletions of telencephalic 5-hydroxytryptamine, with catecholamine levels unchanged. Hyperphagia did not develop despite comparable losses of 5-hydroxytryptamine when the pretreatment was withheld, perhaps because substantial depletions of norepinephrine occurred as well.
D000818:Animals; D001835:Body Weight / Q000187:drug effects*; D001923:Brain Chemistry / Q000187:drug effects*; D005247:Feeding Behavior / Q000187:drug effects*; D009638:Norepinephrine / Q000032:analysis; D051381:Rats; D012527:Satiation / Q000187:drug effects; D012701:Serotonin / Q000032:analysis; D013977:Tibia / Q000254:growth & development; D014363:Tryptamines / Q000494:pharmacology*
D014363:Tryptamines; D012701:Serotonin; D009638:Norepinephrine