Bernstein's and gene-counting methods in generalized ABO-like systems.
Although the simple and adjusted Bernstein's methods are fully efficient for m=2 and m=3 (ABO system) respectively, their efficiency declines for larger values of m. For m greater than or equal to 4, the adjusted or modified Bernstein's method with a single counting iteration leads to a nearly efficient estimator. A single degree of freedom chi-square test of the Hardy-Weinberg law for all m is derived. Some findings on the statistical efficiency of typing various numbers of antigens are given. All the results are illustrated in numerical examples.
D000017:ABO Blood-Group System; D000483:Alleles; D000704:Analysis of Variance; D000941:Antigens; D004330:Drosophila; D004950:Esterases; D005787:Gene Frequency; D006680:HLA Antigens; D006801:Humans; D007938:Leukemia; D008722:Methods
D000017:ABO Blood-Group System; D000941:Antigens; D006680:HLA Antigens; D004950:Esterases