Arterial stenosis, pressure, and flow.
The interaction between the effects of an arterial stenosis and postocclusion hyperemia was studied in a model of the capillaron system. A capillaron is a module consisting of soft-walled permeable vessels (capillaries) in a compliant capsule. Stenosis reduced flow in accord with arterial cross-sectional area. Addition of a capillaron reduced flow to a basal level. In this basal state, autoregulation and postocclusion hyperemia could be studied. Basal flow and autoregulation give no indication of the severity of the stenosis. The magnitude of the postocclusion hyperemia varied with the arterial pressure and, inversely, with the stenotic orifice area. In the absence of arterial pressure changes, the magnitude of the postocclusion hyperemia indicates the severity of the stenosis.
D001157:Arterial Occlusive Diseases / Q000503:physiopathology*; D001783:Blood Flow Velocity; D001794:Blood Pressure; D002197:Capillary Action; D002199:Capillary Permeability; D002200:Capillary Resistance; D003326:Coronary Circulation; D003327:Coronary Disease / Q000503:physiopathology*; D006706:Homeostasis; D006801:Humans; D006940:Hyperemia / Q000503:physiopathology; D008433:Mathematics