Isoniazid-induced convulsions.
Acute isoniazid overdose and toxicity may be complicated by convulsions and death. Six patients are reported, one of whom ingested simultaneously 15 gm of isoniazid and 5 gm of pyridoxine hydrochloride (vitamin B6); no convulsions resulted. In the light of this and other experience, suggestions are made for the use of pyridoxine in the treatment and prevention of acute isoniazid poisoning.
D000293:Adolescent; D000328:Adult; D000818:Animals; D002675:Child, Preschool; D004338:Drug Combinations; D005260:Female; D006801:Humans; D007538:Isoniazid / Q000506:poisoning* / Q000633:toxicity; D008297:Male; D011736:Pyridoxine / Q000008:administration & dosage / Q000627:therapeutic use*; D051381:Rats; D012640:Seizures / Q000139:chemically induced* / Q000188:drug therapy / Q000517:prevention & control
D004338:Drug Combinations; D011736:Pyridoxine; D007538:Isoniazid