Antiarrhythmic actions of DL-sotalol in ventricular and supraventricular arrhythmias.
DL-Sotalol is a unique antiarrhythmic agent combining potent beta-blocking properties with the propensity to prolong cardiac repolarization in all myocardial tissues. Its beta-blocker-associated negative inotropic effects are attenuated by its action potential-lengthening effect. The drug has an elimination half-life of 10-15 h. Sotalol's major electrophysiologic profile constitutes the summed effects of beta-blockade and prolonged repolarization. It exerts a potent antifibrillatory action modulated by its antiadrenergic effects. The effectiveness and tolerance of sotalol in a variety of atrial and ventricular dysrhythmias is reviewed in the present article.
D000818:Animals; D001145:Arrhythmias, Cardiac / Q000188:drug therapy*; D004594:Electrophysiology; D006439:Hemodynamics / Q000187:drug effects; D006801:Humans; D013015:Sotalol / Q000009:adverse effects / Q000493:pharmacokinetics / Q000627:therapeutic use*; D013237:Stereoisomerism
D013015:Sotalol