[Prevention of ventricular fibrillation during the acute phase of experimentally induced myocardial infarction by affecting the ion and acid-base balance of the heart].
For the purpose of prevention of ventricular fibrillation in acute coronary insufficiency a multi-component solution was developed that produces a normalizing effect on the acid-base and ion balance disorders in the heart under ischaemia. The injection of this solution into the left atrium sharply elevated the ventricular fibrillation threshold in cats with an occluded coronary artery. The administration of the solution into the left atrium of dogs following an occlusion of the descending left coronary artery prevented the development of fibrillation in all the experiments, while in the control series of experiments it developed in 62% of cases (p less than 0.001). The solution was decided to posses a high antifibrillation activity that manifests itself when the solution is introduced into the left atrium, and the mechanisms of the beneficial effects of the solution are discussed
D000818:Animals; D002415:Cats; D002712:Chlorides / Q000627:therapeutic use*; D004285:Dogs; D009203:Myocardial Infarction / Q000150:complications*; D012996:Solutions; D014693:Ventricular Fibrillation / Q000209:etiology / Q000517:prevention & control*
D002712:Chlorides; D012996:Solutions
Profilaktika fibrilliatsii zheludochkov v ostroĭ stadii eksperimental'nogo infarkta miokarda putem vozdeĭstviia na ionnoe i kislotno-osnovnoe ravnovesie v serdtse