Kallikrein-kinin system in the angiogenesis.
Using the bioassay to investigate the presence of mediators in the angiogenesis exudate to explain its property to cause vascular permeability and fall in the blood pressure we found the presence of histamine, bradykinin, prostaglandin E2 and angiotensin in the exudate. However, the role of these mediators in the angiogenesis process needs to be investigated.
D000818:Animals; D001681:Biological Assay; D001794:Blood Pressure / Q000187:drug effects; D001920:Bradykinin / Q000494:pharmacology*; D002199:Capillary Permeability / Q000187:drug effects; D002645:Chickens; D002850:Chromatography, Gel; D004064:Digestive System / Q000187:drug effects; D004068:Digestive System Physiological Phenomena; D006168:Guinea Pigs; D066298:In Vitro Techniques; D007610:Kallikreins / Q000302:isolation & purification / Q000378:metabolism* / Q000494:pharmacology; D007705:Kinins / Q000302:isolation & purification / Q000378:metabolism* / Q000494:pharmacology; D008297:Male; D009130:Muscle, Smooth / Q000187:drug effects / Q000502:physiology; D009389:Neovascularization, Pathologic / Q000503:physiopathology*; D051381:Rats; D017208:Rats, Wistar; D012119:Respiration / Q000187:drug effects; D012867:Skin / Q000098:blood supply
D007705:Kinins; D007610:Kallikreins; D001920:Bradykinin