Clearance of indocyanine green as an index of liver function during cyclopropane anaesthesia and induced hypotension.
The rate of decrease in the plasma concentration of indocyanine green (ICG) following a bolus i.v. injection has been studied in two groups of patients before and during anaesthesia. In eight patients anaesthetized with nitrous oxide and oxygen, and who received a neuromuscular blocking drug, induction of anaesthesia was not associated with a significant change in ICG half-life (from 4.59 to 3.85 min) but the subsequent administration of cyclopropane was associated with a statistically significant increase to 5.61 min. In a second group of anaesthetized patients, breathing spontaneously a mixture of oxygen, nitrous oxide and halothane, the induction of arterial hypotension with either lumbar extradural block or sodium nitroprusside was not associated with significant changes in ICG half-life.
D000328:Adult; D000767:Anesthesia, Epidural; D000769:Anesthesia, Inhalation; D001794:Blood Pressure; D003521:Cyclopropanes; D005260:Female; D006339:Heart Rate; D006801:Humans; D007023:Hypotension, Controlled; D007208:Indocyanine Green / Q000378:metabolism; D008099:Liver / Q000378:metabolism*; D008111:Liver Function Tests; D008875:Middle Aged; D009599:Nitroprusside
D003521:Cyclopropanes; D009599:Nitroprusside; D007208:Indocyanine Green