Hyperventilation as the initial manifestation of lymphomatous meningitis.
We present the case of a 57 year old man who developed a B-cell lymphoma which involved his lymph nodes, liver, spleen, bone marrow, and peripheral blood. Shortly after attaining a complete remission with chemotherapy, the patient developed profound hyperventilation with no apparent cardiac or pulmonary cause. After one month, the patient developed a 7th nerve palsy and a subsequent work-up demonstrated that he had lymphomatous meningitis. The hyperventilation resolved completely with intrathecal chemotherapy, although the patient eventually died of widely disseminated lymphoma.
D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D001008:Anxiety Disorders / Q000175:diagnosis*; D003520:Cyclophosphamide / Q000008:administration & dosage; D004317:Doxorubicin / Q000008:administration & dosage; D005158:Facial Paralysis / Q000209:etiology; D006801:Humans; D006985:Hyperventilation / Q000209:etiology*; D007278:Injections, Spinal; D016393:Lymphoma, B-Cell / Q000150:complications* / Q000188:drug therapy / Q000473:pathology; D008297:Male; D008577:Meningeal Neoplasms / Q000150:complications* / Q000188:drug therapy / Q000473:pathology; D008727:Methotrexate / Q000008:administration & dosage; D008875:Middle Aged; D010166:Palliative Care; D011241:Prednisone / Q000008:administration & dosage; D011602:Psychophysiologic Disorders / Q000175:diagnosis*; D014750:Vincristine / Q000008:administration & dosage
D014750:Vincristine; D004317:Doxorubicin; D003520:Cyclophosphamide; D011241:Prednisone; D008727:Methotrexate