title: Hypospadias in successive generations - possible dominant gene inheritance.
abstract: Two families were ascertained with multiple cases of hypospadias. In one family, four generations were reported to be affected and this was proven in three generations. In the second family, a father and two sons were affected. We suggest that dominant gene inheritance may be responsible for a small number of hypospadias cases. The incidence of hypospadias in British Columbia is 1 per 250 live male births and, using Edwards' formula, this gives a theoretical empiric recurrence risk of about 6%.
mesh_terms: D003241:Consanguinity; D005260:Female; D005799:Genes, Dominant; D006801:Humans; D007021:Hypospadias / Q000235:genetics*; D008297:Male; D010375:Pedigree