Spironolactone. III. Canrenone--maximum and minimum steady-state plasma levels.
Steady-state plasma levels of canrenone have been examined in 23 healthy men who received repeated doses of spironolactone for 15 days. The dose regimens were 200 mg once a day and 50 mg 4 times a day. With both treatments the steady-state levels were reached after 3 to 4 days. With once-a-day treatment, the maximum and minimum steady-state levels were about 500 and 100 ng/ml, respectively. The minimum levels with treatment 4 times a day were about 200 ng/ml. The post steady-state half-life of canrenone with once-a-day treatment (19.2 +/- 6.57 hr) was longer (p less than 0.01) than the half-life obtained in the 4 times-a-day treatment (12.5 +/- 3.39 hr). The former half-life was similar to the log-linear phase half-life of canrenone in the single-dose studies.
D000328:Adult; D001628:Beverages; D002192:Canrenone / Q000097:blood*; D004334:Drug Administration Schedule; D005502:Food; D006207:Half-Life; D006801:Humans; D008297:Male; D011245:Pregnadienes / Q000097:blood*; D013148:Spironolactone / Q000008:administration & dosage / Q000378:metabolism*; D013607:Tablets; D013997:Time Factors
D011245:Pregnadienes; D013607:Tablets; D013148:Spironolactone; D002192:Canrenone