Diffuse chronic granulomatous mucocutaneous candidiasis.
A 3-year-old Thai boy with diffuse chronic granulomatous mucocutaneous candidiasis, recurrent bacterial skin infection and adrenal insufficiency is reported. Candida albicans was demonstrated in the dermal granuloma. He had a defect in cell-mediated immunity and was anemic. Although therapy with topical clotrimazole, oral iron, systemic antibiotic and low-dose of prednisone gave a dramatic result, he died of disseminated cryptococcosis.
D000309:Adrenal Insufficiency / Q000150:complications; D002179:Candidiasis, Cutaneous / Q000150:complications / Q000188:drug therapy*; D002675:Child, Preschool; D003022:Clotrimazole / Q000627:therapeutic use; D006105:Granulomatous Disease, Chronic / Q000150:complications*; D006801:Humans; D008297:Male; D010585:Phagocyte Bactericidal Dysfunction / Q000150:complications*
D003022:Clotrimazole