The gp120 glycoprotein of HIV-1 binds to sulfatide and to the myelin associated glycoprotein.
We investigated the binding of the gp120 glycoprotein of the human immunodeficiency virus (HIV-1) to neural glycolipids and glycoproteins by ELISA. The gp120 protein bound to sulfatide (GalS), a sulfated glycolipid autoantigen implicated in sensory neuritis, and to the myelin associated glycoprotein (MAG), an autoantigen in demyelinating neuropathy. Binding of gp120 to MAG was inhibited by the HNK-1 antibody, which recognizes a sulfated glucuronic acid epitope, suggesting that the interaction involves carbohydrate determinants. Sulfatide and MAG are potential receptors for gp120 in peripheral nerve and may have a role in the neuropathy associated with HIV-1 infection.
D000818:Animals; D000911:Antibodies, Monoclonal; D015704:CD4 Antigens / Q000378:metabolism; D004797:Enzyme-Linked Immunosorbent Assay; D006017:Glycolipids / Q000378:metabolism*; D015699:HIV Envelope Protein gp120 / Q000378:metabolism*; D015497:HIV-1 / Q000378:metabolism*; D007700:Kinetics; D051379:Mice; D009185:Myelin Proteins / Q000378:metabolism*; D018992:Myelin-Associated Glycoprotein; D011485:Protein Binding; D011509:Proteoglycans / Q000378:metabolism*; D011994:Recombinant Proteins / Q000378:metabolism; D013433:Sulfoglycosphingolipids / Q000378:metabolism*
D000911:Antibodies, Monoclonal; D015704:CD4 Antigens; D006017:Glycolipids; D015699:HIV Envelope Protein gp120; D009185:Myelin Proteins; D018992:Myelin-Associated Glycoprotein; D011509:Proteoglycans; D011994:Recombinant Proteins; D013433:Sulfoglycosphingolipids