Beta-blockade of morphine-induced hyperlactacidemia in rabbits.
In morphinized rabbits blood lactate levels are elevated. Hyperlactacidemia persists after cessation of morphine injections. This morphine-induced lactate accumulation is completely abolished by simultaneous propranolol treatment. Phentolamine does not modify the action of morphine.
D000818:Animals; D004336:Drug Antagonism; D007773:Lactates / Q000097:blood*; D008297:Male; D009020:Morphine / Q000494:pharmacology*; D010646:Phentolamine / Q000494:pharmacology; D011433:Propranolol / Q000494:pharmacology*; D011817:Rabbits
D007773:Lactates; D009020:Morphine; D011433:Propranolol; D010646:Phentolamine