Influence of prednisolone on intravascular granulocyte kinetics of calves under nonsteady state conditions.
The influence of prednisolone on granulocyte kinetics in calves was evaluated under nonsteady state conditions, using chromium-51 as a cell label. The kinetic pattern observed was similar to that described for persons. Interpretation of results indicated that alteration from steady state to granulocytosis was the result of an increase in input from the storage pool and that shifts occurred in the distribution of cells between the marginating and circulating pools during the period of rapidly changing kinetic patterns. Granulocyte kinetic variables of a calf under induced physiologic stress demonstrated a kinetic pattern similar to that of the calves given prednisolone. There was a rapid enlargement of the total granulocyte pool size and a greater than twofold increase in clearance halftime compared with those in calves of a similar age group.
D000818:Animals; D002417:Cattle / Q000097:blood*; D002418:Cattle Diseases / Q000097:blood; D006098:Granulocytes / Q000187:drug effects*; D007958:Leukocyte Count; D007962:Leukocytes / Q000187:drug effects*; D011239:Prednisolone / Q000494:pharmacology*; D013312:Stress, Physiological / Q000097:blood / Q000662:veterinary; D013997:Time Factors
D011239:Prednisolone