Fracture healing in rats treated with diphenylhydantoin (Dilantin).
Fibula fractures were surgically made in mature male rats. Experimental animals received 4 mg/kg body weight of DPH (Dilantin) injected intraperitoneally, and equivalent volumes of sterile saline were injected intraperitoneally in controls. Fracture healing was assessed by a histologic method 5, 10, 15, 20, 25, and 30 days following the fracture. Thirty days following the injury, the DPH-treated animals showed a statistically significant increased rate of union. A comparison in trends of fracture healing for experimental and control animals showed similar enhancement of fracture healing in the experimental animals throughout the entire observation period.
D000818:Animals; D004195:Disease Models, Animal; D005360:Fibula / Q000187:drug effects; D050723:Fractures, Bone / Q000188:drug therapy* / Q000473:pathology; D008297:Male; D010672:Phenytoin / Q000494:pharmacology / Q000627:therapeutic use*; D051381:Rats; D014945:Wound Healing / Q000187:drug effects*
D010672:Phenytoin