title: Intra-amniotic use of urea and prostaglandin F2 alpha to induce labour in pregnancies complicated by death of the fetus.
abstract: A simple, safe and efficient method of inducing labor in patients in whom pregnancy is complicated by intrauterine death of the fetus is described. The technique involves a single intra-amniotic infusion of 30 mg of prostaglandin F2alpha with 60 g of urea. Fourteen pregnancies complicated by intra-uterine fetal death (ranging in duration from 1 to 7 1/2 weeks) were successfully terminated by this method. Side-effects and complications were minimal. It is submitted that this method provides the obstetrician with a valuable addition to his therapeutic armamentarium. If correctly employed, it provides rapid delivery with minimal risk of discomfort to the patient.
mesh_terms: D000650:Amnion; D005260:Female; D005313:Fetal Death; D006801:Humans; D007263:Infusions, Parenteral; D007751:Labor, Induced; D011247:Pregnancy; D011460:Prostaglandins F / Q000008:administration & dosage*; D014508:Urea / Q000008:administration & dosage*
chemical_list: D011460:Prostaglandins F; D014508:Urea