Effect of dioctyl sodium sulfosuccinate and poloxamer 188 on dissolution and intestinal absorption of sulfadiazine and sulfisoxazole in rats.
The influence of two medicinal surfactants, poloxamer 188 and dioctyl sodium sulfosuccinate, on the dissolution of sulfisoxazole and sulfadiazine was investigated. A dramatic increase in the dissolution rate was observed at all surfactant concentrations. Drug absorption from the rat small intestine was also studied, and a significant but less dramatic increase was noted. Dissolution rate and absorption could be correlated only qualitatively. The two surfactants had no effect on the amount of sulfisoxazole excreted by the rat in 24 hr.
D000818:Animals; D007408:Intestinal Absorption / Q000187:drug effects*; D007700:Kinetics; D000442:Octanols / Q000494:pharmacology; D011060:Poloxalene / Q000494:pharmacology*; D011092:Polyethylene Glycols / Q000494:pharmacology*; D051381:Rats; D012995:Solubility; D013386:Succinates / Q000494:pharmacology*; D013411:Sulfadiazine / Q000378:metabolism*; D013444:Sulfisoxazole / Q000378:metabolism*; D013501:Surface-Active Agents / Q000494:pharmacology*; D013535:Suspensions
D000442:Octanols; D013386:Succinates; D013501:Surface-Active Agents; D013535:Suspensions; D013411:Sulfadiazine; D011092:Polyethylene Glycols; D013444:Sulfisoxazole; D011060:Poloxalene