Amniotic fluid reactivity detected by somatomedin C radioreceptor assay: correlation with growth hormone, prolactin and fetal renal maturation.
Amniotic fluid was assayed by a radioreceptor assay utilizing 125I-somatomedin C and placental membranes. Growth hormone and prolactin levels were measured by radioimmunoassay at different gestational ages (8-41 weeks). Somatomedin receptor activity, growth hormone, and prolactin reached high levels during early gestation (8-26 weeks) displaying different patterns of appearance which reflect fetal serum levels of these hormones. After 26 weeks gestation all these hormones decreased in concentration. This decrease showed a strong correlation with fetal renal maturation as measured by amniotic fluid creatinine levels.
D000653:Amniotic Fluid / Q000032:analysis*; D003404:Creatinine / Q000032:analysis; D005260:Female; D005865:Gestational Age; D013006:Growth Hormone / Q000032:analysis*; D006801:Humans; D007668:Kidney / Q000196:embryology; D011247:Pregnancy; D011388:Prolactin / Q000032:analysis*; D011869:Radioligand Assay; D013002:Somatomedins / Q000032:analysis*
D013002:Somatomedins; D011388:Prolactin; D013006:Growth Hormone; D003404:Creatinine