Glycerol and hyperosmolar nonketotic coma.
Hyperosmolar nonketotic coma occurred in a 29-year-old diabetic man with chronic renal failure after the repeated use of oral glycerol for treatment of acute neovascular glaucoma. Treatment with intravenous hypotonic saline, albumin, and packed red blood cells together with insulin and bicarbonate was successful in overcoming the coma.
D000328:Adult; D000418:Albumins / Q000627:therapeutic use; D001639:Bicarbonates / Q000627:therapeutic use; D003128:Coma / Q000188:drug therapy*; D004231:Diuresis; D004912:Erythrocytes; D005901:Glaucoma / Q000188:drug therapy; D005990:Glycerol / Q000009:adverse effects / Q000627:therapeutic use*; D006801:Humans; D007038:Hypotonic Solutions; D007328:Insulin / Q000627:therapeutic use; D007657:Ketone Bodies / Q000097:blood*; D007676:Kidney Failure, Chronic / Q000139:chemically induced; D008297:Male; D009994:Osmolar Concentration; D012965:Sodium Chloride / Q000627:therapeutic use
D000418:Albumins; D001639:Bicarbonates; D007038:Hypotonic Solutions; D007328:Insulin; D007657:Ketone Bodies; D012965:Sodium Chloride; D005990:Glycerol