The effect of clobetasone butyrate and other topical steroids on skin thickness of the domestic pig.
A new glucocorticoid, clobetasone butyrate, has been shown in patients to have good topical anti-inflammatory activity and a minimal effect on hypothalamic-pituitary-adrenal function. Among a group of topically active corticosteroids, compared in a controlled study in the domestic pig, clobetasone butyrate is shown to cause less epidermal thinning than any of the others except only 1% hydrocortisone. This evidence of a lesser atrophogenic effect may indicate further dissociation of unwanted from wanted properties in clobetasone butyrate.
D000287:Administration, Topical; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology*; D001284:Atrophy / Q000139:chemically induced; D001623:Betamethasone / Q000031:analogs & derivatives* / Q000494:pharmacology; D005260:Female; D005446:Fluocinolone Acetonide / Q000494:pharmacology; D005478:Flurandrenolone / Q000494:pharmacology; D005938:Glucocorticoids; D006854:Hydrocortisone; D012867:Skin / Q000033:anatomy & histology / Q000187:drug effects*; D013552:Swine; D014222:Triamcinolone Acetonide / Q000494:pharmacology
D000893:Anti-Inflammatory Agents; D005938:Glucocorticoids; D005446:Fluocinolone Acetonide; D005478:Flurandrenolone; D001623:Betamethasone; D014222:Triamcinolone Acetonide; D006854:Hydrocortisone