[Mechanism of the induction of asbestos mesotheliomas in the pleura of rats].
The first group of non-bred rats was injected intrapleurally 20 mg of benzene extracted chrysotil-asbestos dust in saline; the second group of rats was injected 20 mg of the same dust but with benz(a)pyrene absorbed on it (0.4 mg). Pleural mesotheliomas were observed in 48.57% of cases in the first group and in 41.37% of cases in the second one. The difference was not significant. There was no difference in the percentage of premesotheliomatous lesions. But, in the second group tumors of other organs were found. The role of asbestos pollution by carcinogenic hydrocarbons in the genesis of lung cancer and pleural mesothelioma is discussed.
D000818:Animals; D001194:Asbestos; D001580:Benzopyrenes; D004195:Disease Models, Animal; D005260:Female; D008297:Male; D008654:Mesothelioma / Q000139:chemically induced*; D010997:Pleural Neoplasms / Q000139:chemically induced*; D051381:Rats
D001580:Benzopyrenes; D001194:Asbestos
O mekhanizme induktsii asbestom mezoteliom plevry krys