title: [The effect of clonidine on renin-release (author's transl)].
abstract: In patients with primary hypertension, intravenous administration of 150 mug Clonidin caused a decrease in arterial pressure, renin activity, RPF, GFR and electrolyte excretion. Activation of intracerebral adrenergic alpha-receptors and diminished sympathetic outflow seem to be responsible for the decrease of renin release.
mesh_terms: D000328:Adult; D003000:Clonidine / Q000494:pharmacology*; D004231:Diuresis / Q000187:drug effects; D005260:Female; D005919:Glomerular Filtration Rate / Q000187:drug effects; D006801:Humans; D006973:Hypertension / Q000503:physiopathology; D007668:Kidney / Q000098:blood supply; D008297:Male; D008875:Middle Aged; D011188:Potassium / Q000378:metabolism; D011941:Receptors, Adrenergic / Q000187:drug effects; D012039:Regional Blood Flow / Q000187:drug effects; D012083:Renin / Q000378:metabolism*; D012964:Sodium / Q000378:metabolism
chemical_list: D011941:Receptors, Adrenergic; D012964:Sodium; D012083:Renin; D003000:Clonidine; D011188:Potassium
vernacular_title: Uber die Beeinflussung der Reninfreisetzung durch Clonidin