Influence of early weaning on the activity of several enzymes in the liver of rat.
In normally weaned rats the activity of two enzymes in rat liver, i.e. ATP citrate lyase and malic enzyme, gradually increases between the end of the third and the beginning of the fourth postnatal week. The activity of mitochondrial alpha-glycerophosphate oxidase remains unchanged during this period. Early weaning on the 18th postnatal day causes a rapid increase in activity of these enzymes. The impulse for this increase is very probably the change from high fat milk diet to high carbohydrate standard laboratory diet, the decrease of blood lipids, the activation of thyroid gland and changes of sensitivity of hepatic cells towards thyroid hormones. These results showed that early weaning modifies to the known picture of physiological weaning to a great extent.
D001275:ATP Citrate (pro-S)-Lyase / Q000378:metabolism*; D000818:Animals; D005993:Glycerolphosphate Dehydrogenase / Q000378:metabolism*; D008099:Liver / Q000201:enzymology*; D008291:Malate Dehydrogenase / Q000378:metabolism*; D008930:Mitochondria, Liver / Q000201:enzymology; D007652:Oxo-Acid-Lyases / Q000378:metabolism*; D051381:Rats; D013997:Time Factors; D014886:Weaning
D005993:Glycerolphosphate Dehydrogenase; D008291:Malate Dehydrogenase; D001275:ATP Citrate (pro-S)-Lyase; D007652:Oxo-Acid-Lyases