Roles of anoxia and noise-induced hearing loss in the postictal refractory period for audiogenic seizures in mice.
The present series of experiments demonstrated a postictal refractory period for audiogenic seizures in DBA/2J mice, which was not related to hearing loss but apparently was related to anoxia. Unlike many previous studies, Experiment 1 controlled for the effects of noise exposure upon hearing sensitivity and demonstrated reduced susceptibility to subsequent audiogenic seizures for at least 1 hr after initial clonic-tonic convulsions. The postictal refractory period was shown to result from the occurrence of seizures per se, not from noise exposure alone. Experiment 2 demonstrated deficiencies of sensorimotor functions that accompanied reduced postictal seizure susceptibility. The two phenomena had similar time courses of recovery, which suggested a common mechanism, probably anoxia, associated with the initial convulsions. In support of this view, Experiment 3 showed that recovery from both phenomena was expedited by allowing subjects to breathe increased O2. The role of anoxia in fatal convulsions was suggested by the finding that subjects experiencing clonic-tonic convulsions in a high-O2 environment survived without exception. In contrast, seizures of air-breathing controls were almost always fatal. Taken together, the data indicate that the postictal reduced susceptibility to audiogenic seizures was closely related to metabolic depletion (in particular, anoxia). The pattern of recovery of susceptibility further suggests that the effects of anoxia impair the spread of seizure activity through the central nervous system, although the initiation of seizures is also affected for a short time.
D000769:Anesthesia, Inhalation; D000818:Animals; D001522:Behavior, Animal; D006317:Hearing Loss, Noise-Induced / Q000150:complications*; D002534:Hypoxia, Brain / Q000150:complications*; D051379:Mice; D008811:Mice, Inbred DBA; D009043:Motor Activity / Q000502:physiology; D009431:Neural Conduction; D010102:Oxygen Inhalation Therapy; D012032:Refractory Period, Electrophysiological; D012640:Seizures / Q000150:complications / Q000209:etiology* / Q000628:therapy; D013997:Time Factors