Effect of metiamide, a histamine H2 - receptor antagonist, on the development of gastric stress ulcers and acid secretion.
In normal and stressed rats with chronic gastric fistula small doses of metiamide (0.001-0.01 muM/kg) increased and doses of over 20 muM/kg decreased gastric acid secretion. In both these dose ranges of dosage metiamide suppressed the development of stress ulcers, most markedly in doses of 0.005 and 100 muM/kg. Intermediate doses had no such action. Only the anti-ulcer action of large doses of metiamide ran parallel to a reduction in acid secretion. Small doses of metiamide increased gastric secretion, but like larger doses, had a weak adrenergic action.
D000818:Animals; D001679:Biogenic Amines / Q000378:metabolism; D001786:Blood Glucose; D001921:Brain / Q000187:drug effects / Q000378:metabolism; D005260:Female; D005750:Gastric Juice / Q000378:metabolism*; D005753:Gastric Mucosa / Q000187:drug effects; D008297:Male; D008785:Metiamide / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D010437:Peptic Ulcer / Q000517:prevention & control*; D051381:Rats; D011955:Receptors, Drug / Q000187:drug effects; D013312:Stress, Physiological; D013890:Thiourea / Q000031:analogs & derivatives*
D001679:Biogenic Amines; D001786:Blood Glucose; D011955:Receptors, Drug; D008785:Metiamide; D013890:Thiourea