[Function, molecular structure and gene expression of granulocyte colony-stimulating factor].
Human granulocyte colony-stimulating factor, a 19KD glycoprotein consisting of 174 amino acids, is one of the physiological regulators mainly produced by monocytes-macrophages, fibroblasts, and endothelial cells, under various stimulations such as neutropenias and infections. The molecule specifically and markedly stimulates the production of neutrophils associated with an expansion of the hemopoietic stem cells/progenitor cells, proliferates myeloid leukemia cells, releases these cells into blood, and elevates the functional activities of neutrophils. Under the favor of the activities, recombinant human granulocyte colony-stimulating factor has now become an epoch-making agents for the treatment of various disorders.
D000595:Amino Acid Sequence; D001483:Base Sequence; D005786:Gene Expression Regulation; D016179:Granulocyte Colony-Stimulating Factor / Q000235:genetics / Q000378:metabolism / Q000502:physiology*; D006801:Humans; D008969:Molecular Sequence Data
D016179:Granulocyte Colony-Stimulating Factor