Familial carcinoma of the pancreas.
A sibship is reported in which four brothers died of adenocarcinoma of the pancreas in the seventh or eighth decade of life. None of the patients had a history of pancreatitis, other malignant neoplasms, or exposure to a known pancreatic carcinogen. This family seems to exhibit a genetic predisposition to pancreatic carcinoma late in life, but the mode of inheritance and the relative importance of genetic and environmental factors in the development of these tumors are unclear.
D000230:Adenocarcinoma / Q000235:genetics* / Q000473:pathology; D000368:Aged; D005260:Female; D006801:Humans; D008099:Liver / Q000473:pathology; D008113:Liver Neoplasms / Q000473:pathology; D008297:Male; D008875:Middle Aged; D009362:Neoplasm Metastasis; D010190:Pancreatic Neoplasms / Q000235:genetics* / Q000473:pathology; D010375:Pedigree