[Distribution of ftorafur in the organism of experimental animals].
Intravenous injection of phtoafur in experimental animals induced the appearance of the biologically active substance in the organism. The concentration of the active substance in blood and organs, reaching its maximum during the first hour, was retained for a long time: an appreciable fall in the substance levels was noted only 12 hours following its injection. In blood and organs of animals with a sensitive tumor levels of the active substance are considerably lower than in intact animals. This seems to condition the therapeutic effect of the drug.
D000818:Animals; D001921:Brain / Q000378:metabolism; D005472:Fluorouracil / Q000031:analogs & derivatives* / Q000097:blood / Q000378:metabolism / Q000652:urine; D005663:Furans / Q000097:blood / Q000378:metabolism / Q000652:urine; D007668:Kidney / Q000378:metabolism; D008099:Liver / Q000378:metabolism; D008168:Lung / Q000378:metabolism; D051379:Mice; D009369:Neoplasms / Q000378:metabolism; D013154:Spleen / Q000378:metabolism; D013997:Time Factors
D005663:Furans; D005472:Fluorouracil
Raspredelenie ftorafura v organizme eksperimental'nykh zhivotnykh