Increased intraocular pressure after third ventricle injections of prostaglandin E1 and arachidonic acid.
Prostaglandin E1 administered into the third ventricle of rabbits produced increased intraocular pressure and body temperature. Similar responses were observed after third ventricle instillation of arachidonic acid, a precursor of prostaglandin E2. Increase of body temperature occurred with lower doses of prostaglandin E1 and arachidonic acid while the intraocular pressure response required larger amounts of these drugs. Pretreatment with aspirin rectal suppositories had no effect on the third ventricle responses induced by prostaglandin E1. Aspirin pretreatment before third ventricle instillation of arachidonic acid blocked the increases of intraocular pressure and temperature.
D000818:Animals; D001095:Arachidonic Acids / Q000008:administration & dosage* / Q000494:pharmacology; D001241:Aspirin / Q000494:pharmacology; D002552:Cerebral Ventricles; D004305:Dose-Response Relationship, Drug; D007267:Injections; D007429:Intraocular Pressure / Q000187:drug effects*; D008297:Male; D011458:Prostaglandins E / Q000008:administration & dosage* / Q000494:pharmacology; D011817:Rabbits
D001095:Arachidonic Acids; D011458:Prostaglandins E; D001241:Aspirin