Elimination of antipyrine and benzo[a]pyrene metabolism in cultured human lymphocytes.
A strong correlation was found in a carefully selected homogenous population (n = 57) between antipyrine plasma half-life and the percent induction of aryl hydrocarbon hydroxylase by 3-methylcholanthrene in mitogen-stimulated lymphocytes from the same individual. The correlation coefficient of r = 0.923 indicates that antipyrine and benzo[a]pyrene share one or several common determinants that are responsible for the observed interindividual variation in the oxidation rates of the two compounds. When a heterogenous population (n = 80) was studied, the above correlation was not found (r = 0.425).
D000328:Adult; D000983:Antipyrine / Q000097:blood*; D001189:Aryl Hydrocarbon Hydroxylases / Q000097:blood; D001580:Benzopyrenes / Q000097:blood*; D002478:Cells, Cultured; D004790:Enzyme Induction; D005260:Female; D006207:Half-Life; D006801:Humans; D007700:Kinetics; D008214:Lymphocytes / Q000201:enzymology / Q000378:metabolism*; D008297:Male; D012737:Sex Factors
D001580:Benzopyrenes; D001189:Aryl Hydrocarbon Hydroxylases; D000983:Antipyrine