Spatial probability learning by alcoholic Korsakoff patients.
Performance of 10 alcoholic Korsakoff patients was compared to that of 10 normal and 10 alcoholic control subjects on each of three different schedules of spatial probability learning (50:50, 70:30, and 30:70) using monetary reinforcement and a correction procedure. There was some evidence that the Korsakoff patients were less sensitive than normals to the effects of reward: Although on all three schedules, choice ratios by normal subjects approximated the reinforcement ratios, the choice ratios of Korsakoffs on the second and third schedules remained close to the reinforcement ratio acquired with the first schedule. In addition, the Korsakoffs made an abnormal number of perseverative errors early in training. On most measures, performance by alcoholic controls fell between that of the other two groups.
D000328:Adult; D000368:Aged; D000425:Alcohol Amnestic Disorder / Q000150:complications / Q000175:diagnosis*; D000437:Alcoholism / Q000503:physiopathology; D004027:Diencephalon / Q000503:physiopathology; D006801:Humans; D008032:Limbic System / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D011337:Probability Learning; D012201:Reward; D013028:Space Perception; D013997:Time Factors