Molecular mechanisms of ageing. A critique.
Two kinds of evidence, taken in conjunction, indicate that Orgel's theory is inapplicable to a wide range of disorders of senescence in man. The age dependence and the anatomical distribution of the lesions of such disorders imply a Burnet type 'forbidden clone' theory of ageing. We describe the difficulty of establishing Orgel's theory for any disorder of ageing in man.
D000375:Aging; D000505:Alopecia / Q000209:etiology; D001112:Arcus Senilis / Q000209:etiology; D003731:Dental Caries / Q000209:etiology; D005260:Female; D005882:Gingival Diseases / Q000209:etiology; D006801:Humans; D008297:Male; D008954:Models, Biological; D009369:Neoplasms / Q000209:etiology