Sterilization of female rats by neonatal placement of estradiol micropellets in anterior hypothalamus.
A pair of micropellets of a 1% or 10% estradiol (E2)-paraffin mixture (containing 0.2 or 2 mug E2, respectively) or paraffin alone were implanted subcutaneously or intracerebrally in 5-day-old female rats. Animals given 10% E2 pellets became sterilized regardless of loci of the pellets. Of those which had received 1% E2 pellets, only animals with micropellets in the anterior hypothalamus became sterilized. It is suggested that neuronal components which are affected irreversibly by neonatal estrogen treatment are localized in the anterior hypothalamus.
D000818:Animals; D000831:Animals, Newborn; D004343:Drug Implants; D004958:Estradiol / Q000008:administration & dosage*; D005260:Female; D006984:Hypertrophy / Q000209:etiology; D007031:Hypothalamus; D007032:Hypothalamus, Anterior; D007033:Hypothalamus, Middle; D007034:Hypothalamus, Posterior; D007247:Infertility, Female / Q000209:etiology*; D008032:Limbic System; D009929:Organ Size; D010049:Ovarian Diseases / Q000209:etiology; D010053:Ovary / Q000033:anatomy & histology; D051381:Rats; D012867:Skin; D014621:Vagina / Q000033:anatomy & histology
D004343:Drug Implants; D004958:Estradiol