Treatment of lumbar disks with chymopapain.
Symptoms arising from a herniated disk appear when the nucleus pulposus or soft inner portion of the disk bulges against a nerve root. When conservative treatment fails to help the patient, the enzyme chymopapain is currently being used in the treatment of such conditions. Injected directly into the disk, the chymopapain dissolves the nucleus by enzymatic action which selectively breaks certain bonds within the nucleus. The pressure within the center is decreased, hence the pressure against the nerve root is relieved, alleviating the symptoms. Because back care is particularly important following such treatment, physical therapy is valuable in promoting continued relief. The major emphasis of the therapy back care program is on abdominal strengthening exercises and postural training.
D002917:Chymopapain / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D010450:Endopeptidases / Q000627:therapeutic use*; D006801:Humans; D007267:Injections; D007405:Intervertebral Disc Displacement / Q000188:drug therapy* / Q000628:therapy; D026741:Physical Therapy Modalities
D010450:Endopeptidases; D002917:Chymopapain