Role of perilymph in the early stage of serous otitis.
After injection of an electron-dense tracer into the cerebrospinal fluid (CSF) the particles can be seen within the lymphatic spaces of the middle ear mucosa after a few minutes. They find their way via the well known communication routes from CSF to the perilymphatic spaces of the inner ear. From there they enter through open fluid spaces into the fibrocytic network of the round window membrane which stands in open relationship to the extracellular fluid spaces of the middle ear mucosa. They were drained to the regional lymph nodes by lymphatic vessels. When inducing a serous otitis by experimental obstruction of the Eustachian tube it could be demonstrated that the fluid within the middle ear cavity is partly coming from the CSF and perilymph. Later the healing process of the middle ear epithelium was studied after the onset of serous otitis with and without artificial ventilation of the middle ear.
D000818:Animals; D002555:Cerebrospinal Fluid; D004195:Disease Models, Animal; D004432:Ear, Middle / Q000473:pathology* / Q000648:ultrastructure; D005122:Exudates and Transudates; D006168:Guinea Pigs; D006874:Hydrostatic Pressure; D007761:Labyrinthine Fluids; D010033:Otitis Media / Q000473:pathology*; D010498:Perilymph; D014432:Tympanic Membrane / Q000473:pathology