Antiserum to somatostatin prevents stress-induced inhibition of growth hormone secretion in the rat.
Plasma growth hormone levels fall and remain low for several hours after stress in the rat. When antiserums to somatostatin are administered to rats prior to stress, growth hormone secretory pulses are partially restored. The results provide evidence that circulating somatostatin plays a prominent role in stress-induced inhibition of growth hormone secretion in the rat.
D000818:Animals; D000937:Antigen-Antibody Reactions; D002940:Circadian Rhythm; D013006:Growth Hormone / Q000097:blood / Q000378:metabolism*; D008027:Light; D051381:Rats; D013004:Somatostatin / Q000276:immunology / Q000502:physiology*; D013312:Stress, Physiological / Q000503:physiopathology*
D013004:Somatostatin; D013006:Growth Hormone