[Penetration of anti-cerebral antibodies through the blood-brain and placental barriers of animals].
The report deals with studies of the penetration of gamma-globulin I131 of rabbit antibrain sera into the different brain areas of intact and sensitized rats and into the placenta of embryo tissues. It was demonstrated that lebeled I131 gamma-globulin containing antibodies to homo- and heterologous brain may in a small amount penetrate from the blood into the CNS of animals. The authors demonstrated as well that labelled antibodies penetrated from the blood of pregnant rats through the placenta and accumulated in the brain and internal organs of the embryo. These facts are significant for development of pathogenesis of an antenatal brain pathology.
D000818:Animals; D000906:Antibodies / Q000378:metabolism*; D001812:Blood-Brain Barrier; D001921:Brain / Q000276:immunology*; D005260:Female; D008431:Maternal-Fetal Exchange; D010920:Placenta / Q000276:immunology; D011247:Pregnancy; D051381:Rats
D000906:Antibodies
O proniknovenii protivomozgovykh antitel cherez gemato-éntsefalicheskiĭ i platsentarnyĭ bar'ery u zhivotnykh