[The pattern of distribution of free amino acids in human amniotic fluid related to the duration of pregnancy. Part I: Changes in concentration in normal pregnancy (author's transl)].
Gas-chromatographic measurement of 18 free amino-acids from about 500 specimens of amniotic fluid between the 10th and 41st week of pregnancy. Statistical methods showed different concentrations of amino-acids in amniotic fluid during pregnancy. Serine, cysteine, methionine and tryptophane show constant concentration. Valine tyrosine and hydroxyproline continuously decrease. The other amino acids tested here show a biphasic course of concentration, falling by about 40-70% between the 10th and the 30th week after which they remain stable. Alanin, threonine, glycine and ornithine show a clear increase of concentration. This diversity of concentration of amino-acids during pregnancy hints at the importance of various factors for the composition of amniotic fluid.
D000409:Alanine / Q000378:metabolism; D000596:Amino Acids / Q000378:metabolism*; D000653:Amniotic Fluid / Q000378:metabolism*; D002849:Chromatography, Gas; D003545:Cysteine / Q000378:metabolism; D005260:Female; D005865:Gestational Age; D005998:Glycine / Q000378:metabolism; D006801:Humans; D006909:Hydroxyproline / Q000378:metabolism; D008715:Methionine / Q000378:metabolism; D009952:Ornithine / Q000378:metabolism; D011247:Pregnancy; D011262:Pregnancy Trimester, Second; D011263:Pregnancy Trimester, Third; D012694:Serine / Q000378:metabolism; D013912:Threonine / Q000378:metabolism; D014364:Tryptophan / Q000378:metabolism; D014443:Tyrosine / Q000378:metabolism; D014633:Valine / Q000378:metabolism
D000596:Amino Acids; D013912:Threonine; D014443:Tyrosine; D012694:Serine; D014364:Tryptophan; D008715:Methionine; D009952:Ornithine; D014633:Valine; D003545:Cysteine; D000409:Alanine; D006909:Hydroxyproline; D005998:Glycine
Das Verteilungsmuster von freien Aminosäuren im menschlichen Fruchtwasser in Abhängigkeit vom Gestationsalter. Teil I: Konzentrationsänderungen bei normaler Gravidität