title: Rate of decay and distribution volume of MB isoenzyme of creatine kinase, intravenously injected into the baboon.
abstract: We determined the decay constant and distribution space of the MB isoenzyme of creatine kinase after intravenous injection of 440 to 720 U, in a group of seven adult baboons. The rate of decay of the isoenzyme was monoexponential, with a mean decay constant of 0.00175 min-1 (SD, 0.00019). The mean distribution volume obtained by extrapolation of the monoexponential curve to zero time was 5.22% (SD, 1.06) of body weight. We have determined these parameters with the purpose of using this isoenzyme in the baboon as an experimental model for measuring myocardial infarct size.
mesh_terms: D000818:Animals; D001835:Body Weight; D003402:Creatine Kinase / Q000097:blood / Q000378:metabolism*; D007527:Isoenzymes / Q000097:blood / Q000378:metabolism*; D010215:Papio / Q000378:metabolism*; D013997:Time Factors
chemical_list: D007527:Isoenzymes; D003402:Creatine Kinase