Structural and metabolic characterization of RNAs from rats with experimental Guerin tumor - II. metabolic peculiarities of RNAs from the liver and tumor tissues of rats.
Metabolic peculiarities of RNAs in the liver of the tumor bearing and in the tumor tissue were found. The synthesis of nuclear RNA in liver of tumor bearing rats is distinctly disordered in comparison to that of control rats. The level of 14C-orotic acid incorporation into RNA of cancer tissue is manifold lower than that into the liver RNA. The studies on turnover rate showed the metabolic heterogeneity of the nuclear RNAs. The part of them showed a short turnover, the other RNAs were degraded much slower.
D000818:Animals; D002250:Carbon Radioisotopes; D002294:Carcinoma, Squamous Cell / Q000378:metabolism*; D008099:Liver / Q000378:metabolism*; D009374:Neoplasms, Experimental; D009963:Orotic Acid; D012334:RNA, Neoplasm / Q000378:metabolism*; D051381:Rats; D013577:Syndrome
D002250:Carbon Radioisotopes; D012334:RNA, Neoplasm; D009963:Orotic Acid