Changes of fast axonal transport by taxol injected subepineurally into the rat sciatic nerve.
In contrast to the complete and long-lasting inhibition of tubulin transport, taxol has no effect on fast axonal transport examined immediately after its sub-epineural application to rat sciatic nerve. However, a significant accumulation of rapidly migrating radioactivity appears at the site proximal to the injection when examined a few weeks after treatment, probably due to mechanical obstruction caused by abnormal aggregation of a huge number of intra-axonal microtubules. It also decreases slightly in amount within a few weeks post-treatment, which may be due to reduction of the number of axons caused by degeneration.
D000818:Animals; D001370:Axonal Transport / Q000502:physiology*; D004591:Electrophoresis, Polyacrylamide Gel; D005724:Ganglia / Q000166:cytology / Q000378:metabolism; D008297:Male; D008845:Microinjections; D008870:Microtubules / Q000378:metabolism; D017239:Paclitaxel / Q000008:administration & dosage / Q000493:pharmacokinetics*; D051381:Rats; D017208:Rats, Wistar; D012584:Sciatic Nerve / Q000378:metabolism*
D017239:Paclitaxel