The reversibility by dipyridamole of the increased sensitivity of in vivo platelet aggregation in rabbits after alloxan.
Rabbits hyperglycaemic after previous intravenous injection with alloxan show an increased sensitivity of the aggregation of platelets to adenosine diphosphate applied topically to injured arteries. This increased sensitivity is completely reversed by treatment with oral dipyridamole but returns if the dipyridamole is withdrawn.
D000244:Adenosine Diphosphate / Q000494:pharmacology; D000818:Animals; D001786:Blood Glucose / Q000032:analysis; D003921:Diabetes Mellitus, Experimental / Q000097:blood*; D004176:Dipyridamole / Q000494:pharmacology*; D008297:Male; D010974:Platelet Aggregation / Q000187:drug effects*; D011817:Rabbits
D001786:Blood Glucose; D000244:Adenosine Diphosphate; D004176:Dipyridamole