title: Spectrum of sinus node dysfunction in two siblings.
abstract: Two siblings, ages 14 and 23, with various features of sinus node dysfunction have been reported. Sinus bradycardia was the presenting feature in both patients. During the follow-up period both patients developed various types of ectopic rhythms which increased with exercise. One of them developed "silent atrium" at the age of 23 and had cerebral embolus as a complication. The other patient had frequent syncopal episodes and had to be treated with a combination of electronic pacemaker and antiarrhythmic drugs.
mesh_terms: D000293:Adolescent; D000328:Adult; D001146:Arrhythmia, Sinus / Q000235:genetics* / Q000503:physiopathology; D004562:Electrocardiography; D005260:Female; D006801:Humans; D012849:Sinoatrial Node / Q000503:physiopathology*