title: Metabolism of 3-(hydroxymethyl)-8-methoxychromone in the rat. II. Classification and identification of urinary drug metabolites.
abstract: 1. Five metabolites were isolated from the urine of dogs dosed with 3-(hydroxymethyl)-8-methoxy[4-14C]chromone. These were identified as 8-methoxychromone, 2-hydroxy-3-methoxyacetophenone, 3-(hydroxymethyl)-8-hydroxychromone, 8-hydroxychromone and 2,3-dihydroxyacetophenone. 2. These compounds were also present in the urine of rats treated with labelled drug, together with unchanged drug and two intermediate metabolites, 3-carboxy-8-methoxychromone and 3-(carboxymethyl)-8-hydroxychromone. 3. In addition to the unconjugated labelled compounds, glucuronides and sulphates were identified. 4. Quantitative data were obtained for all of the 20 labelled compounds in rat urine. 5. A scheme is presented for the biotransformation of 3-(hydroxymethyl)-8-methoxychromone in rats and dogs, and a mechanism for scission of the gamma-pyrone ring is suggested.
mesh_terms: D000818:Animals; D002849:Chromatography, Gas; D002855:Chromatography, Thin Layer; D002867:Chromones / Q000378:metabolism / Q000652:urine*; D005965:Glucuronates / Q000652:urine; D008297:Male; D013058:Mass Spectrometry; D051381:Rats; D013464:Sulfuric Acids / Q000652:urine
chemical_list: D002867:Chromones; D005965:Glucuronates; D013464:Sulfuric Acids