[Correlation analysis in studying the mechanism of action of smooth muscle stimulants].
The presence of correlation between the value of the maximal effects of acetylcholine and other cholinomimetics, as well as serotonin, barium chloride and depolarizing solution was studied on an isolated strip of rat stomach. It was shown that the effect of acetylcholine closely correlated with the effects of other cholinomimetics, to a lesser degree with the effects of barium chloride and depolarizing solution, and least of all with the effect of serotonin. It is proposed to use the degree of this correlation to analyze the point of action of different drugs and processes of coupling the receptor stimulation with the observed effect. It was shown that the point of convergence of the ways of coupling of the three latter influences preceded the convergence of their common way with the way of coupling of the cholinomimetic effects.
D000109:Acetylcholine / Q000494:pharmacology*; D000818:Animals; D001115:Arecoline / Q000494:pharmacology; D001464:Barium / Q000494:pharmacology; D002217:Carbachol / Q000494:pharmacology; D008274:Magnesium / Q000494:pharmacology; D009130:Muscle, Smooth / Q000187:drug effects*; D010277:Parasympathomimetics / Q000494:pharmacology*; D010862:Pilocarpine / Q000494:pharmacology; D051381:Rats; D012701:Serotonin / Q000494:pharmacology; D013268:Stimulation, Chemical; D013270:Stomach
D010277:Parasympathomimetics; D010862:Pilocarpine; D001464:Barium; D012701:Serotonin; D001115:Arecoline; D002217:Carbachol; D008274:Magnesium; D000109:Acetylcholine
Ispol'zovanie korreliatsionnogo analiza dlia izucheniia mekhanizma deĭstviia stimuliatorov gladkoymyschechnykh volokon