[Influence of diazan on the mitotic cycle of leukemia L1210 cells].
By means of a autoradiographic method the effect of diazane - a new antitumor substance from the diasoketones class, on the mitotic cycle of leucimia L 1210 has been studied. Diazane in single administration was found to inhibit the development of leucemic process during 2 days. This substance reduces considerably the DNA synthesis intensity in cells, due to that the mitotic activity of cells is markedly reduced. It was demonstrated that diazane during 8 hours blocked the transfer of cells from a presynthetic stage into the DNA synthesis phase. But this substance does not influence the transfer of cells from the premitotic period into mitosis. The substance delayes continuously (during 36 hours) the division of cells being in a phase of the DNA synthesis during its injection. In later terms although multiplication of these cells would be restored, but its intensity is decreased.
D000818:Animals; D000970:Antineoplastic Agents; D001391:Azo Compounds / Q000627:therapeutic use*; D004247:DNA / Q000096:biosynthesis; D003979:Diazonium Compounds; D004353:Drug Evaluation, Preclinical; D007939:Leukemia L1210 / Q000188:drug therapy*; D007962:Leukocytes / Q000187:drug effects*; D051379:Mice; D008938:Mitosis / Q000187:drug effects*; D013386:Succinates / Q000627:therapeutic use*; D013997:Time Factors
D000970:Antineoplastic Agents; D001391:Azo Compounds; D003979:Diazonium Compounds; D013386:Succinates; C000279:diazan; D004247:DNA
Vliianie diazana na mitoticheskiĭ tsikl kletok leĭkemii L1210