Hypersensitivity pneumonitis induced by hexamethylene diisocyanate.
A case of hypersensitivity pneumonitis (HP) induced by hexamethylene diisocyanate (HDI) is described. Serial determinations of the lymphocyte surface phenotypes by two-color assay revealed the following: 1) increased activated cytotoxic T lymphocytes in the bronchoalveolar lavage fluid (BALF), and 2) increased percentage and absolute number of non-major histocompatibility complex (MHC)-restricted natural killer (NK) cells in the peripheral blood (PB) during the recovery phase of the disease. These findings were considered to be related to the activity of the disease.
D000542:Alveolitis, Extrinsic Allergic / Q000097:blood / Q000139:chemically induced* / Q000473:pathology; D015703:Antigens, CD / Q000032:analysis; D000945:Antigens, Differentiation, T-Lymphocyte / Q000032:analysis; D001992:Bronchoalveolar Lavage Fluid / Q000473:pathology; D019002:CD56 Antigen; D003485:Cyanates / Q000009:adverse effects* / Q000276:immunology; D006801:Humans; D017953:Isocyanates; D007694:Killer Cells, Natural / Q000473:pathology; D016131:Lymphocyte Subsets; D008297:Male; D008875:Middle Aged; D009784:Occupational Diseases / Q000097:blood / Q000139:chemically induced* / Q000473:pathology; D010151:Paintings; D017452:Receptors, IgG / Q000032:analysis
D015703:Antigens, CD; D000945:Antigens, Differentiation, T-Lymphocyte; D019002:CD56 Antigen; D003485:Cyanates; D017953:Isocyanates; D017452:Receptors, IgG; C015262:1,6-hexamethylene diisocyanate