Cytogenetic effects of diazepam in peripheral lymphocytes of self-poisoned persons.
The frequencies of chromosomal aberrations and of micronuclei were determined in lymphocyte cultures of 25 patients who attempted suicide with diazepam, 6-12 h, 72 h and 30 days after self-poisoning. These data were compared with those of healthy controls. The frequencies of numerical aberrations showed a significant increase immediately after self-poisoning. However, this effect could not be detected on the 3rd and 30th days after self-poisoning.
D000293:Adolescent; D000328:Adult; D000782:Aneuploidy; D016009:Chi-Square Distribution; D003975:Diazepam / Q000097:blood / Q000506:poisoning* / Q000652:urine; D062787:Drug Overdose; D005260:Female; D006801:Humans; D008214:Lymphocytes / Q000187:drug effects; D008297:Male; D015162:Micronucleus Tests; D008875:Middle Aged; D013406:Suicide, Attempted
D003975:Diazepam