title: Sex-related difference in antral and serum gastrin levels in the rat.
abstract: Antral and serum gastrin concentrations were found to be significantly lower in female than in male rats. Following ovariectomy, serum gastrin concentration significantly increased to male levels; tissue gastrin also increased, but not significantly. Daily injections of estradiol benzoate (2 mug/day) abolished the rise in gastrin levels after ovariectomy. Antral and serum gastrin concentrations were significantly higher in lactating rats than in any other group tested. The possible relationships among sex-dependent changes in food intake, gastrin concentration, and gastric secretion are discussed.
mesh_terms: D000818:Animals; D002369:Castration; D004958:Estradiol / Q000494:pharmacology; D005247:Feeding Behavior / Q000502:physiology; D005260:Female; D005753:Gastric Mucosa / Q000378:metabolism*; D005755:Gastrins / Q000097:blood / Q000378:metabolism*; D007774:Lactation; D008297:Male; D011247:Pregnancy; D051381:Rats; D012723:Sex
chemical_list: D005755:Gastrins; D004958:Estradiol