The C5b-9 complex: subunit composition of the classical and alternative pathway-generated complex.
The membrane attack complex of complement (C5b-9) is identical in composition regardless of which pathway of activation was instrumental in its formation. Band V protein was consistently a subunit of the soluble complex. Since band V protein is not required for complement-dependent cytolysis, it probably represents a membrane site equivalent in serum of the nascent C5b-9 complex.
D002499:Centrifugation, Density Gradient; D003182:Complement C5 / Q000032:analysis*; D003183:Complement C6 / Q000032:analysis*; D003184:Complement C7 / Q000032:analysis*; D003185:Complement C8 / Q000032:analysis*; D003186:Complement C9 / Q000032:analysis*; D003165:Complement System Proteins / Q000032:analysis*; D004591:Electrophoresis, Polyacrylamide Gel; D006801:Humans
D003182:Complement C5; D003183:Complement C6; D003184:Complement C7; D003185:Complement C8; D003186:Complement C9; D003165:Complement System Proteins