Inclusion group systems and cis-trans effects in responses controlled by the two complementing Ir-GLphi genes.
The immune responses to the random linear terpolymers of L-amino acids, poly-(glu57, lys38, tyr5), poly-(glu51, lys34, tyr15,), and poly-(glu53, lys36, phe11) are each controlled by two dominant H-linked Ir genes. The immune responses to these three related terpolymers demonstrate different H-2 distributions, however, the H-2 patterns are part of a single inclusion group system. The alpha- and beta-genes are dominant; however, most effective gene interactions occur when the two genes are in the cis configuration. The potential significance of this cis-trans effect is discussed.
D000818:Animals; D000917:Antibody Formation; D005799:Genes, Dominant; D008040:Genetic Linkage; D005971:Glutamates / Q000276:immunology; D006649:Histocompatibility Antigens; D008239:Lysine / Q000276:immunology; D051379:Mice; D008815:Mice, Inbred Strains; D010455:Peptides / Q000276:immunology*; D014443:Tyrosine / Q000276:immunology
D005971:Glutamates; D006649:Histocompatibility Antigens; D010455:Peptides; D014443:Tyrosine; D008239:Lysine