Comparative biliary concentrations of cephazolin and cephalothin in patients with biliary tract disease.
The concentration of cephazolin in the serum, gall bladder bile, common duct bile, and gall bladder wall were consideredably higher than cephalothin especially with IV administration and indicate that cephazolin should be a useful antibiotic in the surgical treatment of acute cholecystitis.
D000328:Adult; D001646:Bile / Q000032:analysis*; D002437:Cefazolin / Q000032:analysis* / Q000097:blood / Q000627:therapeutic use; D002511:Cephalosporins / Q000032:analysis*; D002512:Cephalothin / Q000032:analysis* / Q000097:blood / Q000627:therapeutic use; D002763:Cholecystectomy; D002764:Cholecystitis / Q000097:blood / Q000188:drug therapy*; D002769:Cholelithiasis / Q000097:blood / Q000188:drug therapy*; D003135:Common Bile Duct / Q000032:analysis; D005704:Gallbladder / Q000032:analysis; D006801:Humans; D007273:Injections, Intramuscular; D007275:Injections, Intravenous
D002511:Cephalosporins; D002437:Cefazolin; D002512:Cephalothin