[The effect of chlorpropamide on the course of latent insular insufficiency in rats under conditions favorable for its transition to patent diabetes].
Experiments were conducted on 162 female rats which had sustained alloxan diabetes during the period of sexual immaturity and had latent insular insufficiency (prediabetes and latent diabetes). Possibilities of chlorpropamide under conditions promoting decompensation development were studied. The animals were given propamide in daily doses of 100 mg per 1 kg of weight for one month, including the period of sexual maturation. Observation period--up to 5 months. A favourable effect of chlorpropamide was noted by the end of puberty and persisted in the course of further observation; the difference from control animals by the frequency of latent and manifest diabetes was intensified under the effect of glucose overfeeding during the perinatal period. Chlorpropamide improved the course of latent insular insufficiency in the rats and was capable of preventing its change into manifest diabetes.
D000818:Animals; D003921:Diabetes Mellitus, Experimental / Q000188:drug therapy*; D005260:Female; D011236:Prediabetic State / Q000188:drug therapy*; D051381:Rats; D012741:Sexual Maturation
Vliianie khlorpropamide na techenie skrytoĭ insuliarnoĭ nedostatochnosti u krys v usloviiakh, blagopriiatstvuiushchikh perekhodu ee v iavnyĭ diabet