title: Modulation of the release of SRS-A from bovine lung in vitro by several autonomic and autacoid agents.
abstract: The immunological release of slow-reacting substance of anaphylaxis (SRS-A) from bovine lung is modulated by several autonomic and autacoid agents. Isoproterenol, a beta-adrenergic agonist, inhibited release of SRS-A, as did cyclic AMP. Phenylephrine also inhibited SRS-A release but  through alpha-adrenergic mechanisms. This is in contrast to observations in human lung. Carbachol enhanced the release of bovine SRS-A. Histamine inhibited SRS-A release through the H2-receptor. Dopamine enhanced the release of SRS-A by means of a dopaminergic receptor. 5-HT did not significantly modulate SRS-A release.
mesh_terms: D000818:Animals; D002049:Burimamide / Q000494:pharmacology; D002217:Carbachol / Q000494:pharmacology; D002417:Cattle; D004298:Dopamine / Q000494:pharmacology; D006632:Histamine / Q000494:pharmacology; D066298:In Vitro Techniques; D007545:Isoproterenol / Q000494:pharmacology; D008168:Lung / Q000276:immunology*; D008297:Male; D010656:Phenylephrine / Q000494:pharmacology; D013189:SRS-A / Q000276:immunology*
chemical_list: D013189:SRS-A; D010656:Phenylephrine; D006632:Histamine; D002217:Carbachol; D007545:Isoproterenol; D002049:Burimamide; D004298:Dopamine