Enhancement of rIn:rCn-induced interferon production by amphotericin B.
When mouse L929 cells are treated with amphotericin B before exposure to polyriboinosinic-polyribocytidylic acid or polyriboinosinic-polyribocytidylic acid-dextran, they make significantly more interferon than do cells not receiving amphotericin. This effect may be due to enhanced cell membrane penetration by the polynucleotide.
D000666:Amphotericin B / Q000494:pharmacology*; D002463:Cell Membrane Permeability / Q000187:drug effects; D004357:Drug Synergism; D007372:Interferons / Q000096:biosynthesis*; D007739:L Cells; D011070:Poly I-C / Q000494:pharmacology*
D000666:Amphotericin B; D007372:Interferons; D011070:Poly I-C