Treatment of chronic post-traumatic organic brain syndrome with dextroamphetamine: first reported case.
In view of its therapeutic efficacy in the treatment of children with minimal brain dysfunction syndrome, dextroamphetamine was administered to a young adult with a chronic organic brain syndrome secondary to cerebral trauma. That D-amphetamine was critical to the resulting marked diminution in confusion, paranoia, and deficit in short term memory was confirmed by the occurrence of a relapse coincident with placebo administration as part of a double blind evaluation. Amitriptylline appeared to potentiate the therapeutic effects of D-amphetamine. The results achieved, although observational and subjective in nature, warrant replication in controlled, quantitative clinical studies.
D000063:Accidents, Traffic; D000328:Adult; D000639:Amitriptyline / Q000008:administration & dosage / Q000627:therapeutic use; D001930:Brain Injuries / Q000150:complications*; D002746:Chlorpromazine / Q000008:administration & dosage / Q000627:therapeutic use; D003913:Dextroamphetamine / Q000008:administration & dosage / Q000627:therapeutic use*; D004359:Drug Therapy, Combination; D006801:Humans; D008297:Male; D019965:Neurocognitive Disorders / Q000188:drug therapy* / Q000209:etiology
D000639:Amitriptyline; D003913:Dextroamphetamine; D002746:Chlorpromazine