The metabolic and structural changes of the liver in experimental animals after administration of isoprenaline.
Application to rats and rabbits of higher doses of isoprenaline (IP) results in derangement of glycid metabolism, manifested by the decrease of free glycogen (free-GL), and in an even more significant impairment of lipid metabolism, evidenced by an earlier increase of non-esterified fatty acids (NEFA) followed by an increase of esterified fatty acids (EFA) and a concomitant development of fatty infiltration, all indicators of marked lipomobilization. Histograms obtained from hypersensitive individuals show besides fatty infiltrations also necrobiotic processes and structural changes, seen as distinctly marked liver cell membranes. It is perhaps relevant to draw attention to the fact that there are both individual and species differences in the metabolic changes ensuing on application of IP.
D000818:Animals; D005227:Fatty Acids / Q000378:metabolism; D005230:Fatty Acids, Nonesterified / Q000378:metabolism; D005234:Fatty Liver / Q000139:chemically induced; D005998:Glycine / Q000378:metabolism; D007545:Isoproterenol / Q000494:pharmacology*; D008099:Liver / Q000033:anatomy & histology / Q000187:drug effects* / Q000378:metabolism; D011817:Rabbits; D051381:Rats; D013997:Time Factors
D005227:Fatty Acids; D005230:Fatty Acids, Nonesterified; D007545:Isoproterenol; D005998:Glycine