The effects of dietary histidine, methionine and homocystine on vitamin B12 and folate levels in rat liver.
1. L-histidine (20 g/kg) added to vitamin B12-deficient and cyanocobalamin-supplemented diets based on soya-bean flour reduced the growth of rats given the vitamin B12-deficient diet but stimulated growth of rats given the cyanocobalamin-supplemented diet. Liver weight (g/kg body-weight)increased, but the protein content of the livers decreased, in rats given histidine supplements. The histidine was associated with significantly higher folate concentrations in the livers of cyanocobalamin-supplemented rats.
D000818:Animals; D001835:Body Weight; D005260:Female; D005492:Folic Acid / Q000378:metabolism*; D006639:Histidine / Q000494:pharmacology*; D006711:Homocystine / Q000494:pharmacology*; D008099:Liver / Q000378:metabolism*; D008297:Male; D008715:Methionine / Q000494:pharmacology*; D011506:Proteins / Q000378:metabolism; D051381:Rats; D014805:Vitamin B 12 / Q000378:metabolism* / Q000627:therapeutic use; D014806:Vitamin B 12 Deficiency / Q000188:drug therapy / Q000378:metabolism
D011506:Proteins; D006711:Homocystine; D006639:Histidine; D005492:Folic Acid; D008715:Methionine; D014805:Vitamin B 12