Evaluation of the antinociceptive effects of 4, alpha-dimethyl-m-tyramine (H 77/77) in the rat.
4, alpha-Dimethyl-m-tyramine (H 77/77) has been shown to induce dose dependently antinociceptive activity against 3 parameters: (1) the motor (M), (2) the vocalisation during stimulation (V) and (3) the vocalisation after withdrawal of stimulation (VA) responses. The effect of H 77/77 upon the V and VA pain responses was abolished or reduced by prior treatment with phenoxybenzamine, chlorpromazine, H 44/68, FLA 63, reserpine and protriptyline, and was potentiated by atropine sulphate. It is suggested that H 77/77 may exert is inhibitory effect on painful stimulation predominantly by inhibiting spinal sensory input.
D000588:Amines / Q000378:metabolism; D000700:Analgesics / Q000494:pharmacology*; D000818:Animals; D001921:Brain / Q000378:metabolism; D002395:Catecholamines / Q000096:biosynthesis; D003864:Depression, Chemical; D004558:Electric Stimulation; D008297:Male; D051381:Rats; D011955:Receptors, Drug / Q000187:drug effects; D013997:Time Factors; D014439:Tyramine / Q000031:analogs & derivatives* / Q000494:pharmacology; D014828:Vocalization, Animal / Q000187:drug effects
D000588:Amines; D000700:Analgesics; D002395:Catecholamines; D011955:Receptors, Drug; D014439:Tyramine