[Antibiotic penetration through the blood-brain barrier in rats and the effect on this process of proteolytic enzymes].
Penetration of penicillin, ampicillin, oxacillin, tetracycline, streptomycin and gentamycin through the hemato-encephalic barrier in rats and effect of proteolytic enzymes on the above process were studied comparatively. The levels of penetration to the brain were highest for ampicillin, then followed penicillin, tetracycline, oxacillin, streptomycin and gentamycin. Preliminary intramuscular administration of trypsin and chimotrypsin (10 mg/kg) to the animals had no effect on permeability of the hemato-encephalic barrier for the antibiotics tested, except penicillin. Higher levels of the antibiotics in the brain tissue may be explained by higher antibiotic blood levels under the effect of proteolytic enzymes.
D000667:Ampicillin / Q000494:pharmacology; D000818:Animals; D000900:Anti-Bacterial Agents / Q000032:analysis / Q000494:pharmacology*; D001682:Biological Availability; D001812:Blood-Brain Barrier / Q000187:drug effects*; D001923:Brain Chemistry / Q000187:drug effects; D002918:Chymotrypsin / Q000494:pharmacology; D004347:Drug Interactions; D005839:Gentamicins / Q000494:pharmacology; D007700:Kinetics; D010068:Oxacillin / Q000494:pharmacology; D010406:Penicillins / Q000494:pharmacology; D010447:Peptide Hydrolases / Q000494:pharmacology*; D051381:Rats; D013307:Streptomycin / Q000494:pharmacology; D013752:Tetracycline / Q000494:pharmacology; D013997:Time Factors; D014357:Trypsin / Q000494:pharmacology
D000900:Anti-Bacterial Agents; D005839:Gentamicins; D010406:Penicillins; D000667:Ampicillin; D010447:Peptide Hydrolases; D002918:Chymotrypsin; D014357:Trypsin; D013752:Tetracycline; D010068:Oxacillin; D013307:Streptomycin
Proniknovenie antibiotikov cherez gemato-éntsefalicheskiĭ bar'er u krys i vliianie na étot protsess proteoliticheskikh fermentov