title: [Immunology of malignant melanomas].
abstract: The intraperitoneal diffusion-chamber-technique is a closed cell culture system in vivo. Hamster melanoma cells were capable in iso- and heterologous host animals for exponential proliferation. When the host animals had been preimmunized with melanoma cells or hamster lymphocytes a rapid cell lysis was observed in the chambers within 4 hrs after implantation. The cell numbers were reduced about 1-10% of the inoculum. After 6-10 days the cell numbers in chambers from immunized hosts slowly increased in spite of a high level of cytotoxicity in the serum of the animals.
mesh_terms: D000818:Animals; D002478:Cells, Cultured; D006224:Cricetinae; D003601:Cytotoxicity Tests, Immunologic; D008214:Lymphocytes / Q000276:immunology; D008544:Melanocytes / Q000276:immunology; D008545:Melanoma / Q000276:immunology* / Q000473:pathology; D051379:Mice; D009374:Neoplasms, Experimental; D051381:Rats; D012878:Skin Neoplasms / Q000276:immunology* / Q000473:pathology
vernacular_title: Beitrag zur Immunologie der malignen Melanome