Pharmacokinetics of 125I-iothalamate and 131I-o-iodohippurate in man.
The pharmacokinetics of 125I-iothalamate (IOT125I) and 131I-o-iodohippurate (OIH131I) have been studied in patients with varying degrees of renal insufficiency. Both compounds have been shown to obey two-compartment model kinetics after intravenous administration. The clearances are closely related to renal function, but poor correlations were obtained between renal function and compartmental distribution characteristics. This study provides further evidence that IOT125I and OIH131I may be used as indicators of renal function in patients after a single intravenous injection.
D001806:Blood Urea Nitrogen; D003404:Creatinine / Q000378:metabolism; D006207:Half-Life; D006801:Humans; D007465:Iodohippuric Acid / Q000378:metabolism*; D007483:Iothalamic Acid / Q000378:metabolism*; D007676:Kidney Failure, Chronic / Q000378:metabolism; D007700:Kinetics; D008297:Male
D007465:Iodohippuric Acid; D007483:Iothalamic Acid; D003404:Creatinine