title: Anergy and tryptophan metabolism in bladder cancer.
abstract: The tryptophan loading test and cutaneous antigen test were done on 55 patients with various stages of bladder cancer. Patients with an abnormality of tryptophan metabolism showed a greater degree of unreactivity to cutaneous delayed hypersensitivity testing. Of the 23 patients with normal tryptophan metabolism 47 per cent were unreactive to 2 or 3 skin antigens. Of 13 patients with 1 abnormal tryptophan metabolite 62 per cent were unreactive to 2 or 3 skin antigens. Of 19 patients with 2 or more abnormal tryptophan metabolites 68 per cent were unreactive to 2 or 3 antigens.
mesh_terms: D000328:Adult; D000368:Aged; D000941:Antigens; D002295:Carcinoma, Transitional Cell / Q000276:immunology / Q000378:metabolism*; D005260:Female; D006801:Humans; D006967:Hypersensitivity; D008297:Male; D008875:Middle Aged; D014364:Tryptophan / Q000276:immunology / Q000378:metabolism*; D001749:Urinary Bladder Neoplasms / Q000276:immunology / Q000378:metabolism*
chemical_list: D000941:Antigens; D014364:Tryptophan