Enterotoxin B formation by fermentation mutants of Staphylococcus aureus.
An appreciable fraction of carbohydrate-negative (car) mutants of Staphylococcus aureus strains ATCC 14458, 778, and S-6 exhibit increased enterotoxin B (SEB) production. In addition, some lac and mtl mutants of these strains also display enhanced SEB formation. All such mutants appear to be point mutations. Mutagen-induced reversions of high SEB producing car, mtl, or lac mutants yield varying amounts of SEB and some clones seem to be restored to the characteristics of the parent type. A few sequentially isolated lac, mtl double mutants of strain 778 elaborate much more or much less SEB than either the lac or the mtl single mutants.
D050260:Carbohydrate Metabolism; D004768:Enterotoxins / Q000096:biosynthesis*; D005285:Fermentation; D007785:Lactose / Q000378:metabolism; D008353:Mannitol / Q000378:metabolism; D008769:Methylnitronitrosoguanidine; D009153:Mutagens; D009154:Mutation; D013211:Staphylococcus aureus / Q000378:metabolism*; D013696:Temperature
D004768:Enterotoxins; D009153:Mutagens; D008769:Methylnitronitrosoguanidine; D008353:Mannitol; D007785:Lactose