title: N-halo derivatives III: stabilization of nitrogen-chlorine bond in N-chloroamino acid derivatives.
abstract: The chlorination of alpha-amino acids and their related derivatives was investigated. A kinetic study of the stability of these N-chlorinated products led to an elucidation of the factors that significantly influence the stability and reactivity of the nitrogen-chlorine bond in these N-chloramines. From the kinetic investigations, a series of low chlorine potential, soft antimicrobial N-chloramines was developed based on derivatives of alpha-aminoisobutyric acid and related compounds.
mesh_terms: D000596:Amino Acids; D002021:Buffers; D002264:Carboxylic Acids; D055598:Chemical Phenomena; D002621:Chemistry; D002700:Chloramines; D004355:Drug Stability; D007700:Kinetics; D012521:Sarcosine / Q000031:analogs & derivatives
chemical_list: D000596:Amino Acids; D002021:Buffers; D002264:Carboxylic Acids; D002700:Chloramines; D012521:Sarcosine