Antibody response to one and two doses of influenza virus subunit vaccine.
Antibody studies were undertaken to evaluate the responses after one and two-dose schedules of influenza immunization with subunit influenza vaccine. The responses were studied in two adult population groups after the administration of a vaccine containing the most recent epidemic strains A/Pt Chalmers/73 and B/Hong Kong/8/73. Responses to the A component of the vaccine were greater than those to the B strain. Patients with initially low antibody levels responded better than those with higher levels. There was little additional benefit from the second dose of vaccine.
D000328:Adult; D000914:Antibodies, Viral / Q000032:analysis*; D000917:Antibody Formation; D003429:Cross Reactions; D006801:Humans; D007115:Immunization Schedule; D007117:Immunization, Secondary; D007252:Influenza Vaccines / Q000008:administration & dosage*; D009975:Orthomyxoviridae / Q000276:immunology*; D014611:Vaccination
D000914:Antibodies, Viral; D007252:Influenza Vaccines