Inhibition of platelet aggregation by acyl-CoA thioesters.
The aggregation of platelets induced by ADP, collagen, or epinephrine in human platelet-rich plasma is inhibited by long chain acyl-CoA thioesters. Palmityl-CoA exerts a concentration dependent inhibition of collagen-induced aggregation and of the primary and secondary waves of ADP-induced aggregation. Palmityl-CoA also inhibits the secondary wave of epinephrine-induced aggregation but has no effect on the primary wave. This inhibitory effect of palmityl-CoA can be reversed by addition of excess ADP and cannot be attributed to a detergent action.
D000244:Adenosine Diphosphate / Q000037:antagonists & inhibitors / Q000494:pharmacology; D003065:Coenzyme A / Q000494:pharmacology*; D003094:Collagen / Q000037:antagonists & inhibitors / Q000494:pharmacology; D004837:Epinephrine / Q000037:antagonists & inhibitors / Q000494:pharmacology; D006801:Humans; D010169:Palmitic Acids / Q000494:pharmacology; D010974:Platelet Aggregation / Q000187:drug effects*
D010169:Palmitic Acids; D000244:Adenosine Diphosphate; D003094:Collagen; D003065:Coenzyme A; D004837:Epinephrine