title: Stress incontinence: conservative therapy with sympathomimetic drugs.
abstract: There were 77 women with mild to moderate stress urinary incontinence treated with the sympathomimetic agent, phenylpropanolamine hydrochloride, combined with chlorpheniramine maleate and isopropamide iodide in a sustained release capsule (Ornade). The majority of these patients achieved significant improvement 3 months to 3 years after beginning therapy. A trial of conservative therapy is advisable for stress incontinence, especially when symptoms are mild or when the patients are in a poor risk category. Similar management of post-prostatectomy stress incontinence in men was disappointing. However, the occasional excellent results in patients with mild symptoms appear to justify a trial of conservative therapy before considering operative intervention in this group of patients.
mesh_terms: D000284:Administration, Oral; D004809:Ephedrine / Q000627:therapeutic use; D005260:Female; D006801:Humans; D008297:Male; D010665:Phenylpropanolamine / Q000008:administration & dosage / Q000627:therapeutic use*; D014550:Urinary Incontinence, Stress / Q000188:drug therapy*
chemical_list: D010665:Phenylpropanolamine; D004809:Ephedrine