title: [A severe skin reaction following mexiletene].
abstract: A 70-year-old man was treated with oral mexiletene because of ventricular premature beats due to ischemic heart disease. He developed a severe maculopapular rash which did not respond to antiallergic treatment, but disappeared after discontinuation of the drug. Adverse effects on the central nervous, cardiovascular and gastrointestinal systems have been described. A rash is rare, and in our case was of unusual severity.
mesh_terms: D000368:Aged; D005117:Cardiac Complexes, Premature / Q000188:drug therapy; D003875:Drug Eruptions / Q000188:drug therapy / Q000209:etiology*; D006801:Humans; D008297:Male; D008801:Mexiletine / Q000009:adverse effects*
chemical_list: D008801:Mexiletine