Fenfluramine: long-term reduction in brain serotonin (5-hydroxytryptamine).
A single oral dose of 15 mg/kg of fenfluramine reduced the level of serotonin in rat brain to 48, 51 and 63% of control at 1, 15 and 30 days, respectively, after administration. 3 mg/kg p.o. of the drug caused a smaller but significant diminution in brain serotonin. At the 3 mg/kg dose level, the decreases in serotonin were, at least partially, cumulative following multiple injections spaced 24 hr apart. Brains removed 14 days after the 5th daily injection of 5 mg/kg p.o. of fenfluramine had only 60% of the concentration of serotonin found in brains from control animals. These findings demonstrate that fenfluramine has a long-lasting action on serotonin-containing neurons in brain.
D000818:Animals; D001921:Brain / Q000187:drug effects / Q000378:metabolism*; D003864:Depression, Chemical; D004298:Dopamine / Q000378:metabolism; D005277:Fenfluramine / Q000494:pharmacology*; D009638:Norepinephrine / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains; D012701:Serotonin / Q000378:metabolism*; D013997:Time Factors
D005277:Fenfluramine; D012701:Serotonin; D004298:Dopamine; D009638:Norepinephrine