Differential effects of lipids on the osmotic fragility of lysosomes.
The effect of a wide range of concentrations of oleic acid, oleyl alcohol and oleic acid methyl ester on lysosomal stability has been studied under both hypotonic and isoosmotic medium conditions. Both oleic acid and oleyl alcohol exhibited a biphasic interaction pattern with lysosomes; stabilizing at low concentrations and labilizing at high concentrations. Lysosome labilization by the ester required an initial lag period.
D000135:Acid Phosphatase / Q000378:metabolism; D000818:Animals; D002463:Cell Membrane Permeability / Q000187:drug effects; D005231:Fatty Acids, Unsaturated / Q000494:pharmacology*; D008247:Lysosomes / Q000187:drug effects*; D008297:Male; D008566:Membranes / Q000378:metabolism; D009829:Oleic Acids / Q000494:pharmacology*; D009994:Osmolar Concentration; D009996:Osmotic Fragility; D051381:Rats
D005231:Fatty Acids, Unsaturated; D009829:Oleic Acids; D000135:Acid Phosphatase