Effect of ethanol and zinc on ALA-dehydratase activity in red blood cells.
Subcutaneous injection of zinc as sulphate to rats activates sigma-aminolaevulinic acid dehydratase (ALA-D) in red blood cells within few days of injection. This activation counteracts the inhibitory effect of orally administered ethanol.
D000818:Animals; D004912:Erythrocytes / Q000187:drug effects / Q000201:enzymology*; D000431:Ethanol / Q000494:pharmacology*; D006836:Hydro-Lyases / Q000097:blood*; D008297:Male; D000623:Porphobilinogen Synthase / Q000097:blood*; D051381:Rats; D015032:Zinc / Q000097:blood / Q000494:pharmacology*
D000431:Ethanol; D006836:Hydro-Lyases; D000623:Porphobilinogen Synthase; D015032:Zinc