Effects on tissue and electrolytes of a mineralocorticoid blocker during DOCA-induced potassium depletion.
Chronic experiments were carried out on three groups of rats to evaluate tissue and electrolyte effects of a mineralocorticoid blocker canrenoate potassium (SC-14266) during DOCA-induced hypokalemic metabolic alkalosis. Group I animals received DOCA alone, group II received DOCA plus canrenoate, while group III received canrenoate alone. The daily dose ratio (per kilogram of body weight) was 180 mg canrenoate-0.45 mg DOCA. All animals ate a synthetic diet and drank 0.15 N NaHCO3. Group II animals demonstrated a lesser degree of metabolic alkalosis and a higher muscle potassium content when compared with group I rats. The most conspicuous histological abnormality was myocardial necrosis, the degree and extent of which was impressively reduced by the blocking agent.
D000818:Animals; D003864:Depression, Chemical; D003900:Desoxycorticosterone / Q000494:pharmacology*; D008901:Mineralocorticoids / Q000037:antagonists & inhibitors*; D011188:Potassium / Q000378:metabolism*; D051381:Rats; D014882:Water-Electrolyte Balance / Q000187:drug effects*
D008901:Mineralocorticoids; D003900:Desoxycorticosterone; D011188:Potassium