[Stimulation of testicular secretion by chorionic gonadotrophin. Results in normal men and in hypogonadic patients].
In normal adult male, the intra-muscular hCG-test (5000 I.U. X 3) results in a progressive rise of plasma testosterone and dihydrotestosterone, and in a sharp increase of plasma estradiol followed by a decrease although th hCG stimulation is maintained. In testicular dysgenesis, the testosterone and estradiol responses are variable. In adult male gonadotropin deficiency, basal testosterone is always very low, and rises strongly, under hCG-test, only when previous and recent (less than 10 years) exposure to endogenous or exogenous gonadotropin had induced virilization ; by contrast the defective response of estradiol in all cases provides a reliable estimate of the actual gonadotropin deficiency.
D000328:Adult; D000368:Aged; D006063:Chorionic Gonadotropin; D013196:Dihydrotestosterone / Q000378:metabolism*; D004958:Estradiol / Q000378:metabolism; D006801:Humans; D007006:Hypogonadism / Q000175:diagnosis / Q000503:physiopathology*; D008297:Male; D008875:Middle Aged; D012636:Secretory Rate / Q000187:drug effects; D013268:Stimulation, Chemical; D013737:Testis / Q000378:metabolism*; D013739:Testosterone / Q000378:metabolism*
D006063:Chorionic Gonadotropin; D013196:Dihydrotestosterone; D013739:Testosterone; D004958:Estradiol
La stimulation de la sécrétion testiculaire par la gonadotrophine chorionique. Résultats chez l'homme normal et chez les hypogonadiques