title: A functioning pleomorphic carcinoma of the thyroid.
abstract: A metastasizing functioning pleomorphic carcinoma of the thyroid displayed a morphologic piture ranging from follicular to sarcomatous and carcinoid-like patterns. Spindle-cell elements were believed to be the result of metaplasia of the follicular epithelium. Development of carcinoid-like lesions in the secondary deposits of tumour supported the contention that so-called parafollicular or c-cells may be a phenomenon of metaplasia and not a histologic entity. The tumour was associated with a chromophobe adenoma of the pituitary and a benign schwannoma of the stomach. Clinically the patient did not show any other endocrinologic abnormalities and lived for 4 years from the time of diagnosis of the thyroid tumour.
mesh_terms: D000230:Adenocarcinoma / Q000473:pathology*; D000368:Aged; D001344:Autopsy; D002277:Carcinoma / Q000473:pathology; D006801:Humans; D007457:Iodine Radioisotopes / Q000627:therapeutic use; D008175:Lung Neoplasms / Q000473:pathology; D008297:Male; D009362:Neoplasm Metastasis; D009378:Neoplasms, Multiple Primary / Q000473:pathology; D009442:Neurilemmoma / Q000473:pathology; D010911:Pituitary Neoplasms / Q000473:pathology; D013274:Stomach Neoplasms / Q000473:pathology; D013964:Thyroid Neoplasms / Q000473:pathology* / Q000628:therapy
chemical_list: D007457:Iodine Radioisotopes