Effect of bradykinin on portal pressure and protal caliber in the dog. An experimental angiographic study.
Portal pressure and caliber of the portal vein was examined in dogs after bradykinin injection (0.5 mug/kg bodyweitght) into the superior mesenteric artery. Ten experiments were performed. The portal pressure rose from a mean of 10.4 cm H2O to a mean of 21.2 cm H2O after bradykinin injection. The portal vein was dilated in 8 of the 10 experiments. Also the portal circulation time was calculated and decreased after bradykinin injection. Thus, because of the increase in portal pressure and increase in portal circulation care should be exercised when injecting bradykinin into the superior mesenteric artery in patients with portal hypertension and imminent bleeding from oesophageal varices.
D000818:Animals; D001920:Bradykinin / Q000494:pharmacology*; D004285:Dogs; D008102:Liver Circulation / Q000187:drug effects; D011169:Portal Vein / Q000000981:diagnostic imaging / Q000187:drug effects; D011859:Radiography
D001920:Bradykinin