A model for the binding of lac repressor to the lac operator.
A model is suggested for the lac repressor binding to the lac operator in which the repressor polypeptide chain sequences from Gly 14 to Ala 32 and from Ala 53 to Leu 71 are involved in specific interaction with operator DNA. A correspondence between the protein and DNA sequences is found which explains specificity of the repressor binding to the lac operator. The model can be extended to describe specific binding of other regulatory proteins to DNA.
D000595:Amino Acid Sequence; D001426:Bacterial Proteins / Q000378:metabolism; D001665:Binding Sites; D004269:DNA, Bacterial / Q000378:metabolism; D007785:Lactose / Q000378:metabolism*; D046911:Macromolecular Substances; D009690:Nucleic Acid Conformation; D011485:Protein Binding; D014176:Protein Biosynthesis; D011487:Protein Conformation; D014158:Transcription, Genetic
D001426:Bacterial Proteins; D004269:DNA, Bacterial; D046911:Macromolecular Substances; D007785:Lactose