A study of the distribution and origin of myoinositol in the cornea of the rabbit.
The concentration of inositol in the cornea of the rabbit is about one millimole per kilogram tissue water, a level eight- to tenfold that of the aqueous humor. The present study shows that its concentration in the stroma is about the same as in the epithelium and endothelium. Uptake of 2-3H inositol by the corneal layers above the level in the medium was demonstrated in vitro, but the low ratios obtained do not exclusively indicate active transport of the compound. Synthesis of inositol from glucose by the cornea was shown and the estimated rate is compatible with the hypothesis that inositol originates in the cornea and diffuses across the endothelium to the aqueous humor.
D000818:Animals; D001693:Biological Transport, Active; D003315:Cornea / Q000378:metabolism*; D066298:In Vitro Techniques; D007294:Inositol / Q000378:metabolism*; D011817:Rabbits
D007294:Inositol