Role of the granuloma in recurrent Crohn's disease.
The clinical significance of sarcoid-like granulomata in recurrent Crohn's disease has been investigated in 90 patients. The recurrence rate for non-granulomatous disease was double that of granulomatous disease. In granulomatous disease, involvement of the mesenteric lymph nodes did not affect the recurrence rate. This suggests that sarcoid-like granulomata reflect the patients' immune response and support the view that excision of the lymphatic drainage en bloc with affected bowel is not indicated.
D000293:Adolescent; D000328:Adult; D000368:Aged; D002648:Child; D003424:Crohn Disease / Q000150:complications*; D005260:Female; D005500:Follow-Up Studies; D006099:Granuloma / Q000150:complications*; D006801:Humans; D007410:Intestinal Diseases / Q000150:complications*; D008198:Lymph Nodes; D008297:Male; D008875:Middle Aged; D012008:Recurrence