Relationships between the rapid axonal transport of newly synthesized proteins and membranous organelles.
Rapid axonal transport is generally viewed as being exactly analogous to the secretory process in nonneuronal cells. The cell biology of rapid axonal transport is reviewed, the central concern being to explore those aspects that do not fit into the general secretory model and which may thus represent specific neuronal adaptations. Particular attention is paid to the relationship between the transport of newly synthesized proteins and of the membranous organelles that act as carriers. Sites in the transport sequence at which the behavior of axonal transport may differ from the secretory model are at the initiation of axonal transport at the trans-side of the Golgi apparatus, within the axon where molecules are deposited from the moving phase to a stationary phase, and at nerve terminals or axonal lesions where transport reversal takes place.
D000818:Animals; D001370:Axonal Transport; D001369:Axons / Q000378:metabolism; D002462:Cell Membrane / Q000378:metabolism; D007700:Kinetics; D009419:Nerve Tissue Proteins / Q000096:biosynthesis / Q000378:metabolism*; D009474:Neurons / Q000378:metabolism*; D015388:Organelles / Q000378:metabolism*
D009419:Nerve Tissue Proteins