Influence of dietary selenium on lead toxicity in the rat.
An investigation of the influence of dietary selenium (0.015, 0.05, 0.50, 1.0 ppm) on toxicity of dietary lead (0 and 200 ppm) in the young male rat indicated that selenium was mildly protective against the toxic effects of lead, but only up to 0.50 ppm selenium. At the excess selenium dietary level an exaggeration of lead toxicity was observed. Criteria employed to judge the effects of dietary selenium on lead toxicity included tissue lead concentration and urinary delta-aminolevulinic acid excretion. One exception to the exaggeration effect of excess selenium on lead toxicity was the protective effect of selenium on liver delta-aminolevulinic acid dehydratase activity. Since lead depressed kidney selenium concentration, lead may act as an antagonist to selenium metabolism.
D000818:Animals; D001842:Bone and Bones / Q000378:metabolism; D004305:Dose-Response Relationship, Drug; D007668:Kidney / Q000187:drug effects / Q000378:metabolism; D007854:Lead / Q000378:metabolism / Q000633:toxicity*; D007855:Lead Poisoning / Q000517:prevention & control*; D008099:Liver / Q000187:drug effects / Q000378:metabolism; D008297:Male; D000623:Porphobilinogen Synthase / Q000378:metabolism; D051381:Rats; D012643:Selenium / Q000378:metabolism / Q000494:pharmacology* / Q000627:therapeutic use
D007854:Lead; D000623:Porphobilinogen Synthase; D012643:Selenium