Effect of ryanodine on histamine release from rat peritoneal mast cells induced by anti-IgE.
Ryanodine strongly inhibited histamine release from rat peritoneal mast cells induced by anti-IgE. Ryanodine also inhibited Ca(2+)-mobilization from the intracellular Ca(2+)-store as well as histamine release in mast cells activated by anti-IgE. These results suggest that the effect of ryanodine on histamine release from rat mast cells might be due to the inhibition of Ca2+ release from the intracellular Ca2+ store.
D000818:Animals; D000888:Antibodies, Anti-Idiotypic / Q000276:immunology; D002118:Calcium / Q000378:metabolism*; D003864:Depression, Chemical; D006636:Histamine Release / Q000187:drug effects*; D007073:Immunoglobulin E / Q000276:immunology; D008297:Male; D008407:Mast Cells / Q000378:metabolism*; D010529:Peritoneal Cavity / Q000166:cytology; D051381:Rats; D011919:Rats, Inbred Strains; D012433:Ryanodine / Q000494:pharmacology*
D000888:Antibodies, Anti-Idiotypic; D012433:Ryanodine; D007073:Immunoglobulin E; D002118:Calcium