Pitressin-induced inhibition of drinking following water deprivation in the SWR/J mouse.
SWR/J female mice, 8 hr water deprived, were injected intraperitoneally with 0, 10, 50, 200, and 800 mU of aqueous pitressin, 5 min prior to presentation of water. Drinking measurements made at 5, 15, 25, and 35 min of the drinking period revealed a significant transient inhibition of drinking for the three highest dosages. Injections had no measureable effect on blood pressure. Only the highest dosage had an effect on gross motor activity, a significant decline.
D000818:Animals; D004327:Drinking Behavior / Q000187:drug effects*; D005260:Female; D051379:Mice; D008815:Mice, Inbred Strains; D014667:Vasopressins / Q000494:pharmacology*; D014868:Water Deprivation / Q000187:drug effects
D014667:Vasopressins