[Electrophysiological aspects in the mechanism of action of some psychotropic drug agents].
On the basis of the experiments on animals the author made an attempt to find out the place of the action of some psychotropic drugs on the central nervous system and to discover the changes, which occurred in the functional state of various cerebral structures. He used drugs Imupramine (Psychoforin) and Diazepan (Valium), administered localy in some structures of the lymbic system and reticular formation of the cat cerebrum, using stereotaxic technique. The evaluation of the occurred changes was made by the changes in the spontaneous and induced cerebral activity, using the method of double stimuli. The obtained results gave foundation to state that drugs with antidepresive action (Imipramin) inhibited amigdalic complex and the structures connected with it, but benzodiazepines (Diazepam) revealed this action also on the mesencephalic reticular formation as the structures, brocked by the antidepresants, were not affected. In conclusion an electrophysilogic argumentation was made for the combined application of both groups of preparations in neurotic patients.
D000679:Amygdala / Q000187:drug effects; D000818:Animals; D001921:Brain / Q000187:drug effects; D002415:Cats; D003975:Diazepam / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D004558:Electric Stimulation; D004569:Electroencephalography; D004594:Electrophysiology; D005071:Evoked Potentials / Q000187:drug effects; D005260:Female; D007099:Imipramine / Q000494:pharmacology; D008032:Limbic System / Q000187:drug effects; D008297:Male; D011619:Psychotropic Drugs / Q000494:pharmacology*; D012154:Reticular Formation / Q000187:drug effects
D011619:Psychotropic Drugs; D007099:Imipramine; D003975:Diazepam
Elektrofiziologichni aspekti v mekhanizma na deĭstvie na niakoi psikhotropni lekarstveni sredstva