Amino acid transport in normal and glutathione-deficient sheep erythrocytes.
1. Uptake rates for 23 amino acids were measured for both normal (high-GSH) and GSH-deficient (low-GSH) erythrocytes from Finnish Landrace sheep. 2. Compared with high-GSH cells, low-GSH cells had a markedly diminished permeability to D-alanine, L-alanine, alpha-amino-n-butyrate, valine, cysteine, serine, threonine, asparagine, lysine and ornithine. Smaller differences were observed for glycine and proline, whereas uptake of the other amino acids was not significantly different in the two cell types.
D000409:Alanine / Q000378:metabolism; D000596:Amino Acids / Q000378:metabolism*; D000613:Aminobutyrates / Q000378:metabolism; D000818:Animals; D001692:Biological Transport; D003545:Cysteine / Q000378:metabolism; D004912:Erythrocytes / Q000378:metabolism*; D005978:Glutathione / Q000172:deficiency*; D066298:In Vitro Techniques; D007700:Kinetics; D008239:Lysine / Q000378:metabolism; D012756:Sheep; D012964:Sodium / Q000378:metabolism; D013696:Temperature; D013997:Time Factors
D000596:Amino Acids; D000613:Aminobutyrates; D012964:Sodium; D005978:Glutathione; D008239:Lysine; D003545:Cysteine; D000409:Alanine