Naproxen plasma levels in volunteers after single-dose administration by oral and rectal routes.
The bioavailability (plasma concentrations, AUC) of a rectal formulation (suppository) of naproxen was investigated in six healthy volunteers by comparison with an oral preparation (tablets). Plasma half-lives after both formulations were identical 10 hr 15 min+/-25 min (S.D.). Determined by the AUC the bioavailability of naproxen in the suppositories was 94.8%+/-6.3% of the bioavailability of naproxen in the tablets. This paper describes also a new gas-liquid chromatographic method for determining unchanged naproxen in human plasma which is quick, sensitive, and specific.
D000284:Administration, Oral; D000328:Adult; D001682:Biological Availability; D002849:Chromatography, Gas; D005260:Female; D006207:Half-Life; D006801:Humans; D007700:Kinetics; D008297:Male; D009280:Naphthaleneacetic Acids / Q000097:blood*; D009288:Naproxen / Q000008:administration & dosage / Q000097:blood*; D013488:Suppositories; D013997:Time Factors
D009280:Naphthaleneacetic Acids; D013488:Suppositories; D009288:Naproxen