title: Synthesis of N,N'-bis(3-substituted benzylideneaminopropyl)-piperazines and their anti-inflammatory, antiproteolytic, and anticonvulsant properties.
abstract: Some N,N'-bis(3-substituted benzylideneaminopropyl) piperazines were synthesized and characterized by their sharp melting points and elemental analyses. These substituted piperazines possessed anti-inflammatory activity, and the protection afforded by these compounds against carrageenan-induced edema ranged from 23 to 67%. The antiproteolytic activity of these piperazines was reflected by their ability to inhibit in vitro hydrolysis of bovine serum albumin and casein by trypsin. The inhibition of trypsin-induced hydrolysis was concentration dependent and competitive in nature.
mesh_terms: D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology*; D000927:Anticonvulsants / Q000494:pharmacology*; D001597:Benzylidene Compounds / Q000138:chemical synthesis / Q000494:pharmacology; D002364:Caseins / Q000378:metabolism; D002417:Cattle; D005260:Female; D066298:In Vitro Techniques; D008297:Male; D051379:Mice; D010879:Piperazines / Q000138:chemical synthesis / Q000494:pharmacology; D051381:Rats; D012710:Serum Albumin, Bovine / Q000378:metabolism; D014357:Trypsin / Q000378:metabolism; D014361:Trypsin Inhibitors / Q000494:pharmacology*
chemical_list: D000893:Anti-Inflammatory Agents; D000927:Anticonvulsants; D001597:Benzylidene Compounds; D002364:Caseins; D010879:Piperazines; D014361:Trypsin Inhibitors; D012710:Serum Albumin, Bovine; D014357:Trypsin