title: [Effect of temperature on preservation of brucella vaccines].
abstract: In the case of B.19 vaccine, the test of seven days conservation at 37 degrees C does not provide any indication of the long-term conservation of this type of vaccine. The variable results are difficult to interpret, except in extreme cases where the tested vaccine has deteriorated. If this test permits to disclose the deficiencies of lyophilization, it does not permit the stability of this strain to be foreseen. Heating for 30 days at 37 degrees C gives better results, without showing any satisfactory correlation with the duration of validity of the vaccine. Further trials need to be undertaken to try to establish a correlation between an accelerated ageing test and the duration of validity of B.19 vaccine.
mesh_terms: D002002:Brucella / Q000254:growth & development; D002004:Brucella Vaccine / Q000592:standards; D004356:Drug Storage; D013696:Temperature; D013997:Time Factors
chemical_list: D002004:Brucella Vaccine
vernacular_title: Influence de la température sur la conservation des vaccins brucelliques