Systemic contact dermatitis from subcutaneous hydromorphone.
We report a patient who developed a generalized dermatitis after a period of progressive local intolerance to continuous subcutaneous infusion of hydromorphone for cancer pain. Sensitization to hydromorphone was proved by a positive patch test. Infusions with an equianalgesic dose of diacetylmorphine were well tolerated, without local or systemic side-effects, and prolonged the duration of infusion sites.
D003877:Dermatitis, Contact / Q000175:diagnosis / Q000209:etiology* / Q000473:pathology; D004342:Drug Hypersensitivity / Q000209:etiology / Q000473:pathology; D006801:Humans; D004091:Hydromorphone / Q000008:administration & dosage / Q000009:adverse effects*; D007260:Infusion Pumps; D008297:Male; D008875:Middle Aged; D010328:Patch Tests
D004091:Hydromorphone