title: Allergic contact dermatitis to low molecular weight allergens in the chicken.
abstract: We have produced allergic contact dermatitis (ACD) to low molecular weight allergens in the chicken. Sensitization was induced by the application of a high concentration of allergen to a site on the comb previously treated with dimethyl sulfoxide. Challenge, which was made on the wattle with a nonirritating concentration of allergen, resulted in a dermatitis that was grossly and histologically similar to ACD in mammals. Chickens sensitized to oxazolone reacted to that allergen and not to picryl chloride, and conversely. This model provides a unique system wherein to study the T-cell and B-cell contributions to the generation, maintainance and expression of the ACD response.
mesh_terms: D000485:Allergens; D000818:Animals; D002645:Chickens; D003877:Dermatitis, Contact / Q000175:diagnosis / Q000276:immunology*; D004139:Dinitrofluorobenzene / Q000276:immunology; D008297:Male; D008970:Molecular Weight; D010081:Oxazolone / Q000276:immunology; D010853:Picryl Chloride / Q000276:immunology
chemical_list: D000485:Allergens; D010081:Oxazolone; D004139:Dinitrofluorobenzene; D010853:Picryl Chloride