title: [Rapidly progressive glomerulonephritis in a child. Clinical and histological observation over 3 1/2 years (author's transl)].
abstract: At the age of 5 years and 10 months a boy suffered from rapidly progressive glomerulonephritis. After 14 days of treatment with peritoneal dialysis and chlorambucil the acute renal failure was overcome and the kidneys started to function again. 3 1/2 years later 2/3 of normal values for glomerular filtration had been regained, though proteinuria is still 2,8 g/day. Histologically mainly extracapillary proliferations and a partially necrotizing glomerulonephritis were seen in the beginning. 1 1/4 years later sklerosed glomerula predominated (80%) over almost normal glomerula with only minor proliferations. The prognosis remains doubtful in spite of the benign course in the beginning.
mesh_terms: D000208:Acute Disease; D001002:Anuria / Q000628:therapy; D001707:Biopsy, Needle; D002648:Child; D002699:Chlorambucil / Q000627:therapeutic use; D005919:Glomerular Filtration Rate; D005921:Glomerulonephritis / Q000175:diagnosis* / Q000473:pathology / Q000628:therapy; D006801:Humans; D008297:Male; D010530:Peritoneal Dialysis; D011507:Proteinuria / Q000150:complications
chemical_list: D002699:Chlorambucil
vernacular_title: Perakute Glomerulonephritis beim Kind. Klinische und bioptische Verlaufsbeobachtung über 3 1/2 Jahre