title: New compounds: derivatives of methyl 2-aminoacetyl-4,5-dimethoxyphenylacetate.
abstract: Methyl 2-bromoacetyl-4,5-dimethoxyphenylacetate was prepared by reacting cupric bromide with methyl 2-acetyl-4,5-dimethoxyphenylacetate. Aminoacetyl derivatives formed on condensation of substituted p-aminobenzoic esters with the bromoacetyl derivative. Some prepared compounds were tested for local anesthetic and anti-inflammatory activities.
mesh_terms: D062365:Aminobenzoates; D000636:Aminosalicylic Acids; D000779:Anesthetics, Local / Q000494:pharmacology; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology; D055598:Chemical Phenomena; D002621:Chemistry; D003315:Cornea / Q000187:drug effects; D006168:Guinea Pigs; D010648:Phenylacetates / Q000138:chemical synthesis* / Q000494:pharmacology
chemical_list: D062365:Aminobenzoates; D000636:Aminosalicylic Acids; D000779:Anesthetics, Local; D000893:Anti-Inflammatory Agents; D010648:Phenylacetates