[Effect of x-rays on changes in electrolytes and metabolism of the myocardium. VI. Radiation-induced changes of catecholamine content].
In the myocardium of guinea-pigs, the behaviour of the catecholamines noradrenalin and adrenalin as well as the monoamine oxidase activity was biochemically studied following a local irradiation with 250 up to 6000 R surface dose. The noradrenalin content is significantly reduced already after a surface dose of 250 R. This drop of the noradrenalin content is beginning 15 min after irradiation, and not till 72 hours later, a complete normalization of the noradrenalin content is to be shown. A fractionated irradiation with twice 250 R SD in an interval of 24 hours leads to a further reduction. The changes of the adrenalin content are uncharacteristic, the activity of the monoamine oxidase is unaffected.
D000818:Animals; D002395:Catecholamines / Q000378:metabolism*; D004307:Dose-Response Relationship, Radiation; D005260:Female; D006168:Guinea Pigs; D006321:Heart / Q000528:radiation effects*; D008995:Monoamine Oxidase / Q000378:metabolism; D009206:Myocardium / Q000378:metabolism*; D009638:Norepinephrine / Q000378:metabolism; D011830:Radiation Effects; D013997:Time Factors
D002395:Catecholamines; D008995:Monoamine Oxidase; D009638:Norepinephrine
Untersuchungen über den Einfluss von Röntgenstrahlen auf Elektrolytverschiebungen und Stoffwechsel des Herzmuskels. VI. Strahlenbedingte Veränderungen des Katecholamingehaltes