[Changes in the functioning of the anticoagulant system of splenectomized animals during immobilization].
Changes of the anticoagulating system's (ACS) function depend on time elapsing after removal of the spleen, therefore different degrees of ACS activation after 30-min immobilization stress can be observed. In the animals with completely or partially removed spleen, the stress induces activation of the ACS function as expressed by increase in the plasma total fibrinolytic activity, nonfermentative fibrinolysis, decrease in the fibrinogen concentration, activation of the blood plasma anticoagulating function. Hovewer, on the 7th--9th day after removal of the spleen, when the ACS function is thoroughly depressed, the 30-min immobilization stress decreases the plasma anticoagulating activity and, to a certain extent, restricts the appearance of the heparin complex compounds. The latter is due to antagonistic effect of the factor XIII whose activity increases in the blood of the experimental animals. By the 21st day a complete restoration of ACS function occurs in the spleenectomized animals which accounts for the same degree of ACS activation in response to the stress both in the experimental and in control animals.
D000818:Animals; D001777:Blood Coagulation; D005176:Factor XIII / Q000378:metabolism; D005340:Fibrinogen / Q000378:metabolism; D005342:Fibrinolysis; D007103:Immobilization; D008297:Male; D051381:Rats; D013156:Splenectomy; D013312:Stress, Physiological / Q000097:blood* / Q000209:etiology; D013997:Time Factors
D005340:Fibrinogen; D005176:Factor XIII
Izmeneniia funktsii protivosvertyvaiushcheĭ sistemy u splenéktomirovannykh zhivotnykh pri immobilizatsii