[Preparation and testing of different antibrucellic vaccines].
From a highly virulent Brucella melitensis strain of human origin, different vaccines of good antigenic quality are obtained, ranging from the very agglutinogenic oily type vaccine to the totally non-agglutinogenic oily type vaccine. The non-agglutinogenic vaccine is obtained by an original method consisting of submission of the original brucella to several subcultures in the presence of a small quantity of antiserum and clonal selection of a population. The strain finally selected is totally non-agglutinogenic and its biochemical characteristics are hardly different from those of the original strain; it conserves good antigenicity and compares favourably with the other non-agglutinogenic vaccines tested.
D000276:Adjuvants, Immunologic; D000373:Agglutinins / Q000096:biosynthesis; D000818:Animals; D000907:Antibodies, Bacterial / Q000096:biosynthesis; D002002:Brucella / Q000187:drug effects / Q000276:immunology; D002004:Brucella Vaccine / Q000592:standards; D006168:Guinea Pigs; D011817:Rabbits; D012756:Sheep; D012967:Sodium Dodecyl Sulfate / Q000494:pharmacology
D000276:Adjuvants, Immunologic; D000373:Agglutinins; D000907:Antibodies, Bacterial; D002004:Brucella Vaccine; D012967:Sodium Dodecyl Sulfate
Obtention et mise au point de différents vaccins antibrucelliques