Exogenously added free phosphotyrosine induces aggregation of circulating platelets in rabbits.
When free phosphotyrosine is injected into rabbits, circulating aggregated platelets are readily observed in concomitance with altered electrocardiographic profiles. Since phosphotyrosine is also able to induce platelet aggregation in vitro, altogether these results suggest that free phosphotyrosine in blood could be meaningful for in vivo platelet activation.
D000818:Animals; D002478:Cells, Cultured; D004562:Electrocardiography; D006331:Heart Diseases / Q000209:etiology; D066298:In Vitro Techniques; D019000:Phosphotyrosine; D015539:Platelet Activation / Q000502:physiology; D010974:Platelet Aggregation / Q000502:physiology*; D011817:Rabbits; D014443:Tyrosine / Q000031:analogs & derivatives* / Q000502:physiology
D019000:Phosphotyrosine; D014443:Tyrosine