title: Effect of substance P and Sar9Met(O2)11-substance P on cutaneous capillary permeability in guinea pig skin.
abstract: The purpose of this study was to assess the effect of several drugs on the increase in cutaneous capillary permeability induced by intradermal injection of substance P (SP) and Sar9Met(O2)11-SP in guinea pig skin. On the one hand, the increase in cutaneous capillary permeability was partly reduced by spantide, promethazine, atropine or SR 40037, an inhibitor of the angiotensin-converting enzyme. On the other hand, norepinephrine and B3824, a B2-antagonist of bradykinin, showed an enhancing effect. Our results suggest that the effect of SP and Sar9Met(O2)11-SP in guinea pigs is partly mediated by histamine and acetylcholine, and that there is a relationship between tachykinins and bradykinin.
mesh_terms: D000806:Angiotensin-Converting Enzyme Inhibitors / Q000494:pharmacology; D000818:Animals; D001285:Atropine / Q000494:pharmacology; D002199:Capillary Permeability / Q000187:drug effects*; D004396:Coloring Agents / Q000493:pharmacokinetics; D005463:Fluoroacetates; D006168:Guinea Pigs; D007271:Injections, Intradermal; D008297:Male; D009638:Norepinephrine / Q000494:pharmacology; D009842:Oligopeptides / Q000494:pharmacology; D009930:Organic Chemicals; D011398:Promethazine / Q000494:pharmacology; D012867:Skin / Q000098:blood supply*; D013373:Substance P / Q000031:analogs & derivatives* / Q000494:pharmacology*
chemical_list: D000806:Angiotensin-Converting Enzyme Inhibitors; D004396:Coloring Agents; D005463:Fluoroacetates; D009842:Oligopeptides; D009930:Organic Chemicals; C062618:substance P, Sar(9)-Met(O2)(11)-; C069620:B 3824; C078399:SR 40037; D013373:Substance P; D001285:Atropine; C042867:spantide; D011398:Promethazine; D009638:Norepinephrine