Cortisol-dihydrotachysterol antagonism in a patient with hypoparathyroidism and adrenal insufficiency: apparent inhibition of bone resorption.
This report describes a case of chronic mucocutaneous candidiasis with associated hypoparathyroidism and acutely developed adrenocortical insufficiency. The latter was heralded by hypercalcemia. Upon the institution of cortisol therapy, while still under the effects of a vitamin D analog dihydrotachysterol (DHT), the patient exhibited severe hypocalcemia and tetany. Since calcium intake was minimal during this period of presumed corticosteroid-DHT antagonism, it is suggested that the cortisol disturbed calcium homeostasis by in inhibiting bone calcium resorption.
D000309:Adrenal Insufficiency / Q000150:complications* / Q000188:drug therapy; D001862:Bone Resorption; D002118:Calcium / Q000502:physiology; D002179:Candidiasis, Cutaneous / Q000150:complications; D002648:Child; D004097:Dihydrotachysterol / Q000037:antagonists & inhibitors* / Q000627:therapeutic use; D005260:Female; D006706:Homeostasis; D006801:Humans; D006854:Hydrocortisone / Q000494:pharmacology* / Q000627:therapeutic use; D007011:Hypoparathyroidism / Q000150:complications* / Q000188:drug therapy
D004097:Dihydrotachysterol; D002118:Calcium; D006854:Hydrocortisone