[Role of interstitial cells in prostaglandin synthesis in the kidney medulla].
An electron-microscopic study of the interstitial cells of the medulla of the kidneys was carried out after the administration of the inhibitor of prostaglandine synthesis -- indometacine. Under these conditions the amount of lipid granules in the interstitial cells increased significantly. The authors consider the results of study to be an evident proof of participation of lipid granules in the synthetic function of the interstitial cells as a "depôt" of a chemical precursor of prostaglandines synthesized by the interstitial cells.
D000818:Animals; D003238:Connective Tissue / Q000502:physiology*; D003239:Connective Tissue Cells; D007213:Indomethacin / Q000494:pharmacology; D007668:Kidney / Q000378:metabolism*; D007679:Kidney Medulla / Q000166:cytology / Q000187:drug effects / Q000378:metabolism*; D050356:Lipid Metabolism; D008297:Male; D011448:Prostaglandin Antagonists / Q000494:pharmacology; D011453:Prostaglandins / Q000096:biosynthesis*; D051381:Rats
D011448:Prostaglandin Antagonists; D011453:Prostaglandins; D007213:Indomethacin
O roli interstitsial'nykh kletok v sinteze prostaglandinov v mozgovom sloe pochki