[Action of some pyrazolone derivatives on thrombocyte aggregation].
The influence of four agents--pyrazolidinedione derivatives on the ADP-induced aggregation and activity of glycolytic enzymes--glyceraldehydrophosphate dehydrogenase and lactate dehydrogenase (GAPD, LDG) and of the anatomic oxidation enzyme--glucose-6-phosphate dehydrogenase (G-6-PD) was studied. The substances known by a conventional designation of MYaK-38, No-13 and No-2 are shown to display an antiaggregational action. Amidopyrine was found to depress the adhesive capacity of blood platelets, to activate GAPD and LDG and to lower the activity of G-6-PD.
D000244:Adenosine Diphosphate / Q000494:pharmacology; D000632:Aminopyrine / Q000494:pharmacology / Q000633:toxicity; D000818:Animals; D001769:Blood / Q000187:drug effects; D001777:Blood Coagulation / Q000187:drug effects; D001792:Blood Platelets / Q000187:drug effects / Q000201:enzymology; D003720:Densitometry; D005954:Glucosephosphate Dehydrogenase / Q000097:blood; D005993:Glycerolphosphate Dehydrogenase / Q000097:blood; D066298:In Vitro Techniques; D007770:L-Lactate Dehydrogenase / Q000097:blood; D010974:Platelet Aggregation / Q000187:drug effects*; D011720:Pyrazoles / Q000494:pharmacology* / Q000633:toxicity; D011817:Rabbits; D051381:Rats; D013925:Thromboplastin / Q000032:analysis; D013997:Time Factors
D011720:Pyrazoles; D000632:Aminopyrine; D000244:Adenosine Diphosphate; D013925:Thromboplastin; D005993:Glycerolphosphate Dehydrogenase; D007770:L-Lactate Dehydrogenase; D005954:Glucosephosphate Dehydrogenase
Deĭstvie nekotorykh proizvodnykh pirazolona na agregatsiiu trombotsitov