Sex-related difference in antral and serum gastrin levels in the rat.
Antral and serum gastrin concentrations were found to be significantly lower in female than in male rats. Following ovariectomy, serum gastrin concentration significantly increased to male levels; tissue gastrin also increased, but not significantly. Daily injections of estradiol benzoate (2 mug/day) abolished the rise in gastrin levels after ovariectomy. Antral and serum gastrin concentrations were significantly higher in lactating rats than in any other group tested. The possible relationships among sex-dependent changes in food intake, gastrin concentration, and gastric secretion are discussed.
D000818:Animals; D002369:Castration; D004958:Estradiol / Q000494:pharmacology; D005247:Feeding Behavior / Q000502:physiology; D005260:Female; D005753:Gastric Mucosa / Q000378:metabolism*; D005755:Gastrins / Q000097:blood / Q000378:metabolism*; D007774:Lactation; D008297:Male; D011247:Pregnancy; D051381:Rats; D012723:Sex
D005755:Gastrins; D004958:Estradiol