title: Minocycline hydrochloride (Minocin) as a single-dose oral treatment of uncomplicated gonorrhoea in men.
abstract: 349 male patients with uncomplicated gonococcal urethritis were treated with a single dose of 300 mg. or 400 mg. minocycline hydrochloride. The lower dose gave a lower failure rate, 3-2 compared with 5-1 per cent., but this difference was not statistically significant. The overall known failure rate of 4-2 per cent. compares most favourably with our previous findings in this area using other drugs of the tetracycline group. The incidence of post-gonococcal urethritis (5-1 per cent.) was also the lowest we have found. The few side-effects reported were comparatively trivial. Because of its high degree of therapeutic efficacy, the relatively lack of side-effects, and the reduced incidence of post-gonococcal urethritis, minocycline hydrochloride should be considered the drug of choice whenever single-dose oral treatment is given in uncomplicated gonorrhoea in men.
mesh_terms: D000284:Administration, Oral; D005500:Follow-Up Studies; D006069:Gonorrhea / Q000188:drug therapy*; D006801:Humans; D008297:Male; D008911:Minocycline / Q000008:administration & dosage* / Q000627:therapeutic use; D013754:Tetracyclines / Q000008:administration & dosage*
chemical_list: D013754:Tetracyclines; D008911:Minocycline