[Participation of thyroid hormones in realization of the action of diphtheria toxin on oxidative phosphorylation in rabbit liver mitochondria].
Experiments were conducted on rats with an experimental hypo- and hyperthyroidism. In hypothyroidism there was no disturbance of the capacity to phosphorylation conjugated with respiration in the mitochondria from the liver in intravenous injection of diphtheria toxin, but in hyperthyroidism sensitivity of mitochondria of the liver to the uncoupling action of diphtheria toxin was much increased. It is supposed that of great significance for the uncoupling action of diphtheria toxin on the oxidative phosphorylation was the incretory function of the thyroid gland.
D000818:Animals; D004167:Diphtheria Toxin; D006980:Hyperthyroidism / Q000378:metabolism*; D007037:Hypothyroidism / Q000378:metabolism*; D008930:Mitochondria, Liver / Q000187:drug effects / Q000378:metabolism*; D010085:Oxidative Phosphorylation / Q000187:drug effects*; D011817:Rabbits
D004167:Diphtheria Toxin
Ob uchastii tireoidnykh gormonov v realizatsii deĭstviia difteriĭnogo toksina na okislitel'noe fosforilirovanie v mitokhondriiakh iz pecheni krolikov