Persistence of neuroadapted mumps virus in brains of newborn hamsters after intraperitoneal inoculation.
Neuroadapted mumps virus produces systemic infection in newborn hamsters after intraperitoneal inoculation. Virus is disseminated via a low-level viremia and appears to enter the central nervous system by passage through the choroid plexus. At such sites, choroidal and ependymal epithelial cells are productively infected and become a source for further viral spread throughout the brain parenchyma. The development of neutralizing and hemagglutination-inhibiting antibodies in serum correlates with the clearance of virus from most systemic sites. However, peristence of virus in both brain and kidney is demonstrated late in this infection.
D000818:Animals; D000831:Animals, Newborn / Q000382:microbiology*; D000914:Antibodies, Viral / Q000032:analysis; D001769:Blood / Q000382:microbiology; D001921:Brain / Q000382:microbiology*; D002555:Cerebrospinal Fluid / Q000382:microbiology; D006224:Cricetinae; D007274:Injections, Intraperitoneal; D007668:Kidney / Q000382:microbiology; D008099:Liver / Q000382:microbiology; D008590:Meningoencephalitis / Q000209:etiology / Q000382:microbiology*; D009109:Mumps virus / Q000276:immunology / Q000302:isolation & purification*; D013154:Spleen / Q000382:microbiology
D000914:Antibodies, Viral