Effect of taurine on responses to noradrenaline, acetylcholine and ouabain in isolated auricles from digitalized guinea pigs.
Responses of the isolated heart from the guinea pig treated chronically with digitoxin until the T wave had disappeared were studied. The development of the abnormal ECG pattern was abolished by a simultaneous injection of taurine and digitoxin. Taurine also inhibited the change by digitoxin of the responses to acetylcholine and ouabain but not to noradrenaline. The causal relationship between the inhibitory effect of taurine and prevention of the development of arrhythmias remains obscure.
D000109:Acetylcholine / Q000494:pharmacology*; D000818:Animals; D003864:Depression, Chemical; D004074:Digitoxin / Q000494:pharmacology*; D004562:Electrocardiography; D006168:Guinea Pigs; D006325:Heart Atria / Q000187:drug effects*; D006339:Heart Rate / Q000187:drug effects; D066298:In Vitro Techniques; D008297:Male; D009206:Myocardium / Q000378:metabolism; D009638:Norepinephrine / Q000494:pharmacology*; D010042:Ouabain / Q000494:pharmacology*; D013654:Taurine / Q000378:metabolism / Q000494:pharmacology*; D013997:Time Factors
D013654:Taurine; D010042:Ouabain; D004074:Digitoxin; D000109:Acetylcholine; D009638:Norepinephrine