Age-related phenomena in the lumbar intervertebral discs. Lipofuscin and amyloid deposition.
In 69 lumbar intervertebral discs from 69 autopsies, lipofuscin was seen in discs from individuals older than 50 years of age and amyloids in the discs of individuals older than 40 years of age. In 261 intervertebral disc tissue specimens collected at the time of surgery for disc herniation, lipofuscin was seen in the discs of individuals older than 20 years of age and amyloids in the discs of individuals older than 15 years of age. It is speculated that amyloids and lipofuscin are a sign of aging in the intervertebral disc as in other tissues. Furthermore, amyloids and lipofuscin were seen in the operated discs of young individuals than in the autopsy cases.
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000378:metabolism*; D000682:Amyloid / Q000032:analysis*; D002648:Child; D006801:Humans; D007403:Intervertebral Disc / Q000378:metabolism*; D007405:Intervertebral Disc Displacement / Q000378:metabolism; D008062:Lipofuscin / Q000032:analysis*; D008159:Lumbar Vertebrae / Q000378:metabolism*; D008875:Middle Aged; D013194:Staining and Labeling
D000682:Amyloid; D008062:Lipofuscin