Effect of nomifensine on acetylcholine and choline in the rat striatum and brainstem.
Nomifensine, at a dose of 40 mg/kg, slightly but significantly increased rat striatal acetylcholine 60 min after i.p. administration without affecting choline levels or choline O-acetyltransferase and cholinesterase activities. This drug had no effect on brainstem acetylcholine. In contrast, d-amphetamine and desipramine both produced a small but significant increase in brainstem acetylcholine. It is suggested that nomifensine increased striatal acetylcholine indirectly through blockade of dopamine uptake.
D000109:Acetylcholine / Q000378:metabolism*; D000818:Animals; D000928:Antidepressive Agents / Q000494:pharmacology*; D001933:Brain Stem / Q000187:drug effects / Q000378:metabolism*; D002794:Choline / Q000378:metabolism*; D002802:Cholinesterases / Q000378:metabolism; D003342:Corpus Striatum / Q000187:drug effects / Q000378:metabolism*; D003891:Desipramine / Q000494:pharmacology; D003913:Dextroamphetamine / Q000494:pharmacology; D005260:Female; D066298:In Vitro Techniques; D007546:Isoquinolines / Q000494:pharmacology*; D051381:Rats
D000928:Antidepressive Agents; D007546:Isoquinolines; D002802:Cholinesterases; D002794:Choline; D000109:Acetylcholine; D003891:Desipramine; D003913:Dextroamphetamine