Determination of structure-activity relationships of 2-aryl-1,3-indandiones.
The uncoupling activities in rat liver mitochondria of a number of 2-aryl-1,3-indandiones were studied by means of the Free-Wilson method followed by a stepwise regression analysis. The activity appears to be mainly dependent on the hydrophobic parameter.
D007189:Indans / Q000494:pharmacology*; D007192:Indenes / Q000494:pharmacology*; D008930:Mitochondria, Liver / Q000187:drug effects; D012044:Regression Analysis
D007189:Indans; D007192:Indenes