[Toxic action of influenza virus on lymphoid-macrophagal reactions in guinea pigs].
Influenza viruses with different degrees of virulence for the human being produced various reactions of the lymphoid-macrophagal elements in the peritoneal exudate of guinea pigs inoculated intraperitoneally. The higher the virulence of the strain for the human being -- the deeper the inhibition of the lymphoid and macrophagal cells of guinea pigs. Low virulent strains of influenza virus induced a considerable functional activity of macrophages, but were devoid of the lympholytic activity. Because of close corrleation between the virulence of the virus and the cellular content of the exudate the lymphocytic-macrophagal reaction in the animals resistant to influenza virus could serve for determination of the toxic activity of the viruses under study.
D000818:Animals; D001202:Ascitic Fluid / Q000166:cytology; D006168:Guinea Pigs; D008214:Lymphocytes; D008264:Macrophages; D009975:Orthomyxoviridae; D014774:Virulence
Izuchenie toksicheskogo deĭstviia virusa grippa na limfoidno-makrofagal'nye reaktsii morskikh svinok