The effect of dibromodulcitol (Elobromolr, Mitolactolr, nsc 104 800) on the postoperative recurrences of the Guerin carcinoma of the rat.
In all cases of Guerin carcinoma of the rat the recurrence of the tumor in 7-10 days can be observed following surgical removal. Local treatment with Dibromodulcitol combined with intraperitoneal administration of the same drug results in delayed occurrence of tumor recurrences, the growth of which is slower, and in a significant increase of life span of the animals. In exceptional cases no recurrence appeared. The local treatment combined with intraperitoneal administration was the most effective. Peroral treatment was also effective although in a lesser degree.
D000818:Animals; D002294:Carcinoma, Squamous Cell / Q000601:surgery*; D002470:Cell Survival / Q000187:drug effects; D008936:Mitolactol / Q000494:pharmacology / Q000627:therapeutic use*; D009364:Neoplasm Recurrence, Local / Q000188:drug therapy*; D009368:Neoplasm Transplantation; D009374:Neoplasms, Experimental; D011183:Postoperative Complications / Q000188:drug therapy*; D051381:Rats; D013577:Syndrome; D014184:Transplantation, Homologous
D008936:Mitolactol