Thrombokinetics in systemic lupus erythematosus A preliminary report.
Twelve non-thrombocytopenic patients ( 3 males and 9 females) with systemic lupus erythematosus (SLE) were investigated with respect to platelet size, percentage of megathrombocytes, platelet survival and platelet production. The values for platelet size and percentage of megathrombocytes did not differ from those of a control group. In the SLE group the mean platelet MLS was identical to the control mean, and all patients with SLE had values for platelet MLS within the range of the control subjects. All SLE patients but one had values for platelet turnover within the control range. For unclear reason one single SLE patient had a moderately elevated platelet turnover value. The results of the present investigation do not support the theory that a state of compensated thrombocytolysis is present in SLE.
D000328:Adult; D000368:Aged; D001379:Azathioprine / Q000494:pharmacology / Q000627:therapeutic use; D001772:Blood Cell Count; D001792:Blood Platelets / Q000032:analysis* / Q000187:drug effects; D002470:Cell Survival / Q000187:drug effects; D005260:Female; D005938:Glucocorticoids / Q000494:pharmacology / Q000627:therapeutic use; D006801:Humans; D007700:Kinetics; D008180:Lupus Erythematosus, Systemic / Q000097:blood* / Q000188:drug therapy; D008297:Male; D008875:Middle Aged; D009929:Organ Size; D013154:Spleen / Q000502:physiology*
D005938:Glucocorticoids; D001379:Azathioprine