title: Genetic aspects of nutritional rickets.
abstract: Amino acid excretion was investigated in 21 rachitic infants and in 22 of their parents. There was (a) increased alpha-amino acid excretion in one-third of the infants a long time after the rickets had healed, (b) an abnormally high excretion of alpha-amino nitrogen and of phosphorus in many of the parents (c) an abnormal pattern of amino acid excretion in all 9 infants tested, and (d) a good correlation between the excretion of individual amino acids by an infant and by its parents. Our findings suggest that in at least some cases of nutritional rickets there is a genetic element which may manifest itself only under adverse environmental conditions.
mesh_terms: D000328:Adult; D000469:Alkaline Phosphatase / Q000097:blood; D000596:Amino Acids / Q000652:urine*; D002118:Calcium / Q000097:blood; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D010758:Phosphorus / Q000097:blood / Q000652:urine; D012279:Rickets / Q000188:drug therapy / Q000235:genetics* / Q000652:urine; D014807:Vitamin D / Q000627:therapeutic use
chemical_list: D000596:Amino Acids; D014807:Vitamin D; D010758:Phosphorus; D000469:Alkaline Phosphatase; D002118:Calcium