title: Morphology and distribution of supraependymal cells in the third ventricle of the albino rat.
abstract: The supraependymal cells (SEC) are a normal component of the wall of the cerebral ventricles. In the hypothalamic area of the third ventricle they are restricted, in healthy animals, to the ependymal projection of the hypophyseotropic area. Here the SEC show great polymorphism. In addition to bipolar, multipolar and stellate or spider-like cells, transitional forms between these types can be seen. Their perikarya and processes can either remain at some distance from the ependyma or be in close contact with it. The processes may protrude between the ependymal cells or show surface differentiations that resemble the thin cytoplasmic folds of the mesenchymal wandering cells. Considering this and the variations in the number of cells, for example during the ovarian cycle, the SEC can be interpreted as mesenchymal cells, probably related to microglial cells of the subependymal layer. It is suggested that the SEC have a phagocytotic function and may be involved in the normal renewal of the ependyma. A definitive explanation for the restriction of the SEC to the hypophyseotropic area as well as the elucidation of their function remain to be found.
mesh_terms: D000818:Animals; D002552:Cerebral Ventricles / Q000648:ultrastructure*; D004805:Ependyma / Q000648:ultrastructure; D005260:Female; D007031:Hypothalamus / Q000648:ultrastructure; D008297:Male; D010586:Phagocytes; D051381:Rats