[The state of anticoagulant system of animals following injections of purified thrombin and N-acetyl-thrombin].
I. v. administration of N-acetyl-thrombin, similar to thrombin, increases the fermentative fibrinolytic potency of the plasma, although to a lesser extent. This is also expressed in the increased esterase activity of the plasma and euglobulin fraction. When blocking the forming plasmin, esterase activity is observed in kallekreine. (The inhibitory effect of plasma after N-acetyl-thrombin administration tells also on the nonfermentative fibrinolytic activity of the Fibrinogen-Heparin complex, activity of the latter dropping practically to the zero level. Warming up at 60 degrees C decreases the nonfermentative fibrinolytic activity of the complex N-acetyl-thrombin (thrombin-esterase) does not provoke the activation of the second anticoagulang system, while the native thrombin does it.
D000818:Animals; D001777:Blood Coagulation / Q000187:drug effects*; D004950:Esterases / Q000097:blood; D008297:Male; D051381:Rats; D012712:Serum Globulins / Q000378:metabolism; D013917:Thrombin / Q000031:analogs & derivatives* / Q000494:pharmacology*
D012712:Serum Globulins; D004950:Esterases; D013917:Thrombin
Sostoianie protivosvertyvaiushcheĭ sistemy zhivotnykh posle in"ektsii preparatov ochishchennogo trombina i N-atsetil-trombina