Lymphocyte nucleoli activation as a marker of autoimmune disorder development. I. Observation in NZB mice.
An increased number of lymphocytes with nucleoli synthesizing RNA was found in blood and lymph nodes of aged NZB mice who developed an autoimmune disease. This was not observed in young NZB mice and in 40NX mice where no immune disorders were noted.
D000367:Age Factors; D000818:Animals; D001327:Autoimmune Diseases / Q000097:blood*; D002466:Cell Nucleolus / Q000378:metabolism*; D007958:Leukocyte Count; D008198:Lymph Nodes; D008213:Lymphocyte Activation; D008214:Lymphocytes / Q000378:metabolism* / Q000648:ultrastructure; D051379:Mice; D008814:Mice, Inbred NZB / Q000276:immunology*; D012313:RNA / Q000096:biosynthesis
D012313:RNA