Drug interactions in intestinal absorption of 3H-digitoxin in rats.
The absorption of 3H-digitoxin from perfused rat small intestine was inhibited by probenecid (1.0 x 10-2 M), ethacrynic acid (0.5 x 10-3 M), and mersalyl (8.0 x 10-3 M) indicating that digitoxin absorption is at least partly an active process.
D000818:Animals; D004074:Digitoxin / Q000097:blood / Q000378:metabolism*; D004976:Ethacrynic Acid / Q000494:pharmacology*; D007408:Intestinal Absorption / Q000187:drug effects; D007421:Intestine, Small / Q000187:drug effects / Q000378:metabolism*; D007668:Kidney / Q000378:metabolism; D008099:Liver / Q000378:metabolism; D008297:Male; D008634:Mersalyl / Q000494:pharmacology*; D009132:Muscles / Q000378:metabolism; D009941:Organomercury Compounds / Q000494:pharmacology*; D011339:Probenecid / Q000494:pharmacology*; D051381:Rats
D009941:Organomercury Compounds; D008634:Mersalyl; D004074:Digitoxin; D004976:Ethacrynic Acid; D011339:Probenecid