title: [Character of changes in protease inhibitory capacity of blood in experimental osteoarticular tuberculosis].
abstract: All the steps of osteoarticular tuberculosis evolution were accompanied by an increase in proteolytic activity in rabbit blood serum, which was compensated by activation of alpha 1-inhibitor of proteinases at the initial steps of osteitis. The system "proteinases-inhibitors" was imbalanced during the severe phases of arthritis independently on the rate of its development as follows: predominance of proteolytic potential over inhibitory activity, dissimilar activity of alpha 1-inhibitor of proteinases simultaneously with equal rate of alpha 2-macroglobulin content decrease. Dissimilar alterations in the system studied enabled to suggest that differential application of proteinases is suitable for treatment of inflammation with respect to the step of osteoarticular tuberculosis development.
mesh_terms: D000818:Animals; D006868:Hydrolysis; D007249:Inflammation / Q000097:blood / Q000150:complications; D011480:Protease Inhibitors / Q000097:blood*; D011817:Rabbits; D014394:Tuberculosis, Osteoarticular / Q000097:blood* / Q000150:complications; D000515:alpha 1-Antitrypsin / Q000378:metabolism; D000511:alpha-Macroglobulins / Q000378:metabolism
chemical_list: D011480:Protease Inhibitors; D000515:alpha 1-Antitrypsin; D000511:alpha-Macroglobulins
vernacular_title: Kharakter izmeneniĭ pokazateleĭ proteazno-ingibitornoĭ emkosti krovi pri éksperimental'nom kostno-sustavnom tuberkuleze.