Comparison of the pharmacokinetics of penicillin G and ampicillin in the horse.
The affinity and the binding capacity of horse serum proteins for ampicillin and penicillin G were measured by equilibrium dialysis or ultrafiltration technique. From the figures thus obtained it may be concluded that in the range of therapeutic concentrations the protein-bound fraction accounts for 6 X 8-8 per cent of the total ampicillin concentration and for 52-54 per cent of the total penicillin G concentration in serum. The rate of elimination of ampicillin and penicillin G in horses was assessed by following serum concentrations after a single intravenous injection. The biological half life of ampicillin was found to be 93 min and that of penicillin G 53 min in adult horses with unimpaired circulation and intact kidney and liver function.
D000667:Ampicillin / Q000097:blood*; D000818:Animals; D001798:Blood Proteins / Q000032:analysis; D007700:Kinetics; D010400:Penicillin G / Q000097:blood*; D011485:Protein Binding
D001798:Blood Proteins; D000667:Ampicillin; D010400:Penicillin G