Estrogen-progestogen interaction: factors influencing progesterone-induced endometrial changes of the uterus of the immature rabbit.
In orally estrogen-primed animals, four times as much progesterone is required to bring about secretory changes comparable to those obtained following subcutaneous priming. These findings might be interpreted as evidence that: (a) oral estrogen-induced proliferative changes are either different or inadequate, and (b) excess progesterone is conditio sine qua non for the induction of those proliferative changes susceptible of being transformed into secretory ones.
D000284:Administration, Oral; D000818:Animals; D004717:Endometrium / Q000187:drug effects*; D004958:Estradiol / Q000494:pharmacology; D004997:Ethinyl Estradiol / Q000494:pharmacology; D005260:Female; D007279:Injections, Subcutaneous; D011374:Progesterone / Q000494:pharmacology*; D011800:Quinestrol / Q000494:pharmacology; D011817:Rabbits
D004997:Ethinyl Estradiol; D011374:Progesterone; D004958:Estradiol; D011800:Quinestrol