[Effect of chymotrypsin on the urinary excretion of antibiotics in rabbits].
The effect of cymotrypsin on excretion of penicillin, methicillin, oxacillin, streptomycin and gentamycin with urine including the kidney clearance was studied on rabbits. It was found that the enzyme introduced intramuscularly in a dose of 20 mg/kg increased excretion of penicillin, methicillin, oxacillin and gentamycin by 37, 24, 26 and 16 per cent respectively. The only exclusion was streptomycin. Chymotrypsin increased the kidney clearance of penicillin, methicillin, oxacillin, streptomycin and gentamycin by 1.7, 1.9, 2.2, 1.2 and 1.5 times respectively.
D000818:Animals; D000900:Anti-Bacterial Agents / Q000652:urine*; D002918:Chymotrypsin / Q000494:pharmacology*; D005839:Gentamicins / Q000652:urine; D008297:Male; D008657:Metabolic Clearance Rate / Q000187:drug effects; D008712:Methicillin / Q000652:urine; D010068:Oxacillin / Q000652:urine; D010406:Penicillins / Q000652:urine; D011817:Rabbits; D013307:Streptomycin / Q000652:urine; D013997:Time Factors
D000900:Anti-Bacterial Agents; D005839:Gentamicins; D010406:Penicillins; D002918:Chymotrypsin; D008712:Methicillin; D010068:Oxacillin; D013307:Streptomycin
Vliianie khimotripsina na vyvedenie antibiotikov s mochoĭ u krolikov