Two toxic indole alkaloids from Penicillium islandicum.
Two new isomeric metabolites, toxins A and B, were isolated from culture extracts of Penicillium islandicum. Both toxins had a molecular formula of C16H15O2N2Cl, and physical and chemical analyses indicated that they were indole alkaloids. LD50 of toxin A was about 75-125 mg/kg in day-old cockerels. Insufficient toxin B was available to determine accurate LD50 values. Toxin A moderately inhibited growth of wheat coleoptiles but did not inhibit growth of week-old intact corn and bean plants. Toxin B showed no plant-growth inhibition.
D000470:Alkaloids / Q000096:biosynthesis*; D000818:Animals; D010367:Arachis; D002645:Chickens; D005516:Food Microbiology; D007211:Indoles; D007928:Lethal Dose 50; D009183:Mycotoxins / Q000096:biosynthesis* / Q000633:toxicity; D010407:Penicillium / Q000302:isolation & purification / Q000378:metabolism*; D014908:Triticum / Q000187:drug effects / Q000254:growth & development
D000470:Alkaloids; D007211:Indoles; D009183:Mycotoxins