The effect of aspirin on 5-hydroxytryptamine uptake and release by human platelets.
The influence of aspirin on 5-hydroxytryptamine (5-HT) uptake and storage by human blood platelets has been investigated. Uptake of 5-HT was strongly inhibited. In 30 min aspirin released 50% of the 5-HT that had been incorporated into the platelets prior to the addition of the aspirin. These results are discussed in terms of possible interference with a 5-HT membrane receptor and the impairment of 5-HT storage in the dense granules.
D001241:Aspirin / Q000494:pharmacology*; D001792:Blood Platelets / Q000187:drug effects / Q000378:metabolism*; D003864:Depression, Chemical; D006801:Humans; D066298:In Vitro Techniques; D011796:Quinacrine / Q000494:pharmacology; D012701:Serotonin / Q000097:blood*; D013997:Time Factors
D012701:Serotonin; D011796:Quinacrine; D001241:Aspirin