[Phthalimide derivatives of pyrimidine and thiazole heterocyclics].
The synthesis of some phthalimido-derivatives of the pyrimidine and thiazole ring systems is described. The functional groups have been suitably selected to enhance structural analogy with the pairs of pyrimidine and purine bases present in nucleic acids. In preliminary tests some of these compounds have shown inhibitory activity towards RNA polymerase reaction in vitro.
D012321:DNA-Directed RNA Polymerases / Q000037:antagonists & inhibitors; D010797:Phthalimides / Q000138:chemical synthesis*; D011743:Pyrimidines / Q000138:chemical synthesis*; D013844:Thiazoles / Q000138:chemical synthesis*
D010797:Phthalimides; D011743:Pyrimidines; D013844:Thiazoles; D012321:DNA-Directed RNA Polymerases
Ftalimmido-derivati di eterocicli pirimidinici e tiazolici