Increased lung compliance in mice exposed to sulfur dioxide.
Mice exposed 6-9 days to 40 ppm. SO2 lost 21% of body weight, but static lung compliance increased 37% (P less than or equal to 0.01). Slopes of saline volume-pressure curves increased 8% (non-sig) pointing to a decrease in surface tension rather than tissue elasticity. Alveolar stability, lung weight and lung wet/dry ratio decreased 2 to 6%, whereas trapped gas in-increased 17%, but none were statistically significant.
D000818:Animals; D001835:Body Weight / Q000187:drug effects; D005260:Female; D066298:In Vitro Techniques; D008170:Lung Compliance / Q000187:drug effects*; D051379:Mice; D009929:Organ Size / Q000187:drug effects; D011650:Pulmonary Alveoli / Q000187:drug effects; D013458:Sulfur Dioxide / Q000494:pharmacology*
D013458:Sulfur Dioxide