Mitotic changes in neuroblastoma transplanted into denervated host tissue.
Tumors were transplanted to denervated and innervated hind limbs of A/J mice and grown for 5 days in all groups. The host tissues were denervated by femoral and sciatic nerve section 4 days prior to tumor implantation. Dnervation of host tissues resulted in a significant reduction in tumor mitotic rate as assessed by mitotic counts in the histological sections. Neurotrophic factors may thus be an additional feature of the host-tumor environment.
D000818:Animals; D003714:Denervation; D005260:Female; D006614:Hindlimb / Q000294:innervation; D051379:Mice; D008938:Mitosis / Q000187:drug effects*; D009368:Neoplasm Transplantation; D009374:Neoplasms, Experimental / Q000503:physiopathology*; D009447:Neuroblastoma / Q000503:physiopathology*; D014184:Transplantation, Homologous