Evidence for both luminal and systemic factors in the control of rat intestinal epithelial replacement.
1. Isolation of a self-emptying sac of rat small intestine in vivo halved the cell production rate in the crypts of Lieberkühn as measured by colchicine blockade. 2. Starvation for 48 h of rats with isolated intestinal sacs caused a further halving of cell production rate in the sac. 3. Infusion of distilled water into isolated intestinal sacs for 72 h caused a similar degree of stimulation of cell production in sacs in fed and starved rats, suggesting that the fall in cell production rate on starving a rat bearing an isolated sac is not due to t-e non-availability of the substances required for cell synthesis. 4. The possible contribution of innervation of the gut, and of systemic hormonal influences, on intestinal epithelial replacement is discussed.
D000818:Animals; D002455:Cell Division / Q000187:drug effects; D003078:Colchicine / Q000494:pharmacology; D004847:Epithelial Cells; D004848:Epithelium / Q000502:physiology; D008297:Male; D051381:Rats; D013217:Starvation
D003078:Colchicine