Induction of an LH surge with estradiol benzoate. A clinical test of pituitary-hypothalamic axis competence.
Intramuscular injection of 6.6 mg of estradiol benzoate (EB) in oil was used in 34 women as a test of the ability of the pituitary-hypothalamic axis to produce a gonadotropin surge (positive-feedback response). These responses were compared to Clomid responses. All of the normal cycling women, two-thirds of oligo-ovulatory but menstruating women, and one-third of amenorrheic women had LH surges to EB challenge. Estradiol benzoate is a more specific test of positive feedback response than Clomid. It also may be effective in inducing ovulation in some amenorrheic patients refractory to Clomid treatment.
D000328:Adult; D000568:Amenorrhea / Q000188:drug therapy; D002996:Clomiphene; D004958:Estradiol / Q000627:therapeutic use; D005246:Feedback; D005260:Female; D005640:Follicle Stimulating Hormone / Q000378:metabolism; D006801:Humans; D007030:Hypothalamo-Hypophyseal System / Q000502:physiology*; D007231:Infant, Newborn; D007986:Luteinizing Hormone / Q000097:blood*; D011247:Pregnancy
D002996:Clomiphene; D004958:Estradiol; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone