title: GLC determination of quinidines in human plasma.
abstract: Human plasma was made alkaline and extracted with methylene chloride. To the extract was added the internal standard, cinchonine, followed by evaporation to dryness. The resultant residue was dissolved in a methanolic solution containing trimethylanilinium hydroxide. This solution was assayed by GLC for quinidines (quinidine and hydroquinidine). Evaluation of the method over a 0.5-10-mug/ml range in human plasma gave an overall precision and accuracy of +/- 4.5% (RSD and RE). Plasma of several patients was analyzed by the present method as well as by a fluorometric method for the level of quinidines. Results from the two methods were comparable.
mesh_terms: D002849:Chromatography, Gas; D002855:Chromatography, Thin Layer; D004355:Drug Stability; D006801:Humans; D011802:Quinidine / Q000031:analogs & derivatives* / Q000097:blood
chemical_list: D011802:Quinidine