[Pharmacological properties of the methylamide of N-(4-antipyril)-oxaminic acid (oxapyrine)].
Comparative results of a pharmacological study on amidopyrine and a new original drug--N-(4-antipyril)-oxaminic methylamide are reported. Investigations conducted on animals showed the anodyne action of amidopyrine to manifest itself in toxic doses. This drug has a direct depressing effect on an isolated heart, a length of the intestine and the uretus of test animals. When employed in experimental conditions N-(4-antipyril) oxaminic methylamide displayed a much greater analgesic action that did amidipyrine. The drug has low toxicity both with its single and systemic introduction for a period of 60 days and it produces no inhibitory effect on isolated smooth muscle organs. It is concluded that the advantages of the newly synthetized agent come as a result of purposefully made structural changes in the formula, viz by introduction of a hydrazine group and of an oxaminic radical in the side chain.
D000284:Administration, Oral; D000632:Aminopyrine / Q000031:analogs & derivatives* / Q000494:pharmacology / Q000633:toxicity; D000818:Animals; D000983:Antipyrine / Q000031:analogs & derivatives; D001794:Blood Pressure / Q000187:drug effects; D002415:Cats; D004305:Dose-Response Relationship, Drug; D005260:Female; D007275:Injections, Intravenous; D007279:Injections, Subcutaneous; D008297:Male; D051379:Mice; D051381:Rats; D013997:Time Factors
D000632:Aminopyrine; C012467:oxapyrine; D000983:Antipyrine
Farmakologicheskie svoĭstva metiamida N-(4-antipiril)-oksaminovoĭ kisloty (oksapirina)