Immunologic evaluation of beta-lipoprotein antigen in the serum of men exposed to carbon disulfide over protracted periods of time.
beta-Lipoprotein was isolated by the precipitation method from collective serum of 47 men aged 27-49 years (mean 42-1 years) exposed to carbon disulfide during work over long periods of time. Significantly elevated levels of serum beta-lipoprotein, clinical and polycardiographic symptoms were found in 85-1% of subjects. Antibodies to beta-lipoprotein obtained by immunizing rabbits intravenously were compared with similar antibodies in healthy subjects by double immunodiffusion in agar and by the passive hemagglutination test. Both tests showed identical antigens.
D000328:Adult; D000906:Antibodies / Q000032:analysis; D000941:Antigens; D001161:Arteriosclerosis; D004781:Environmental Exposure; D006801:Humans; D008074:Lipoproteins / Q000097:blood* / Q000276:immunology; D008297:Male; D008875:Middle Aged; D013997:Time Factors
D000906:Antibodies; D000941:Antigens; D008074:Lipoproteins