Saturable first-pass metabolism of sulfisoxazole N1-acetyl in rats.
Saturable metabolism of sulfisoxazole N1-acetyl in the rat during the initial pass of the drug from the intestinal lumen through the liver following oral administration of the drug (saturable first-pass metabolism) was investigated. The fraction of the total amount of drug recovered from the urine as the N4-conjugate fraction was apparent following the intravenous administration of sulfisoxazole acetyl or the oral administration of sulfisoxazole at the same dose levels.
D000284:Administration, Oral; D000818:Animals; D001682:Biological Availability; D007275:Injections, Intravenous; D008297:Male; D051381:Rats; D013444:Sulfisoxazole / Q000008:administration & dosage / Q000378:metabolism* / Q000652:urine; D013997:Time Factors
D013444:Sulfisoxazole