Stevens-Johnson syndrome from ophthalmic sulfonamide.
A 71-year-old man, who had a history of a previous bullous drug reaction to a sulfonamide, began receiving an ophthalmic preparation that contained sulfacetamide sodium. The patient received only the ophthalmic sulfonamide, and it was used for one day, but he developed Stevens-Johnson syndrome. This is believed to be the first reported case of Stevens-Johnson syndrome caused by an ophthalmic sulfonamide. The sulfonamides are the best verified drug-trigger for erythema multiforme and Stevens-Johnson syndrome.
D000368:Aged; D003231:Conjunctivitis / Q000188:drug therapy; D006801:Humans; D007239:Infections / Q000188:drug therapy; D008297:Male; D009883:Ophthalmic Solutions; D013211:Staphylococcus aureus; D013262:Stevens-Johnson Syndrome / Q000139:chemically induced*; D013449:Sulfonamides / Q000008:administration & dosage / Q000009:adverse effects*
D009883:Ophthalmic Solutions; D013449:Sulfonamides