Effects of perhexiline maleate on coronary flow distribution in the ischemic canine myocardium.
Intravenous perhexiline maleate in a canine preparation with fixed coronary flow increases coronary diastolic pressure. It also redistributes coronary flow so as to preserve endocardial flow. Myocardial oxygen consumption was reduced and lactate uptake enhanced by the drug. It had no effect upon the threshold for ischemic-induced left ventricular failure.
D000818:Animals; D003326:Coronary Circulation / Q000187:drug effects*; D003327:Coronary Disease / Q000188:drug therapy / Q000503:physiopathology*; D004285:Dogs; D008168:Lung / Q000098:blood supply; D009206:Myocardium / Q000378:metabolism; D010101:Oxygen Consumption; D010480:Perhexiline / Q000494:pharmacology* / Q000627:therapeutic use; D010880:Piperidines / Q000494:pharmacology*
D010880:Piperidines; D010480:Perhexiline