No indication of postnatal selection at the HL-A loci.
When the HL--A allele frequency and the distribution of 2, 3 and 4 different antigens, respectively, in children and old people were compared no differences could be observed between the two groups. The data thus disprove a simple model by which HL--A heterozygosity should enhance surveillance.
D000367:Age Factors; D000368:Aged; D000483:Alleles; D002648:Child; D002675:Child, Preschool; D005787:Gene Frequency; D014644:Genetic Variation; D006680:HLA Antigens; D006579:Heterozygote; D006649:Histocompatibility Antigens; D006650:Histocompatibility Testing; D006801:Humans
D006680:HLA Antigens; D006649:Histocompatibility Antigens