A nitrofurantoin-induced disorder simulating chronic active hepatitis. A case report.
A 78-year-old woman with liver damage resembling chronic active hepatitis and occuring during long-term nitrofurantoin treatment is described. On admission to hospital she displayed jaundice, ascites and high serum levels of GOT, GPT, bilirubin and gamma-globulin as well as high titres of ANF and antibodies against smooth muscle cells. After withdrawal of nitrofurantoin the clinical and laboratory picture normalized without corticosteroid treatment, suggesting that the liver reaction was drug-induced.
D000368:Aged; D000410:Alanine Transaminase / Q000097:blood; D001219:Aspartate Aminotransferases / Q000097:blood; D056486:Chemical and Drug Induced Liver Injury / Q000175:diagnosis*; D002908:Chronic Disease; D003937:Diagnosis, Differential; D005260:Female; D006505:Hepatitis / Q000175:diagnosis*; D006801:Humans; D008099:Liver / Q000187:drug effects*; D008107:Liver Diseases / Q000097:blood / Q000201:enzymology; D009582:Nitrofurantoin / Q000009:adverse effects* / Q000627:therapeutic use; D014552:Urinary Tract Infections / Q000188:drug therapy
D009582:Nitrofurantoin; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase