Bile salts and bioelectric properties of rat jejunum.
Addition of conjugated bile salts increased transmural- and transserosal-potential differences of sheets of rat jejunum. Removal of Cl- from buffer solutions minimized the bile-sale induced bioelectric changes. Bile-salt induced doubling of tissue resistance was not explained by an observed increase in net Cl- serosa leads to mucosa flux. Electrical effects were unrelated to concentration and were observed only when bile-salt solutions perfused the jejunal mucosa. The molecular events associated with bile-salt interactions with the plasma membrane affecting ion fluxes may relate to their unique effects on sterol absorption.
D000818:Animals; D001647:Bile Acids and Salts / Q000494:pharmacology*; D002712:Chlorides / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D007413:Intestinal Mucosa / Q000187:drug effects; D007474:Ion Exchange; D007583:Jejunum / Q000187:drug effects / Q000502:physiology*; D008297:Male; D008564:Membrane Potentials / Q000187:drug effects*; D011199:Potentiometry; D051381:Rats; D012964:Sodium / Q000494:pharmacology; D013431:Sulfates / Q000494:pharmacology
D001647:Bile Acids and Salts; D002712:Chlorides; D013431:Sulfates; D012964:Sodium