N-nitroso-bis(2-acetoxypropyl)amine as a further pancreatic carcinogen in Syrian golden hamsters.
N-Nitroso-bis(2-acetoxypropyl)amine, a possible beta metabolite of N-nitroso-di-n-propylamine, was shown to be a potent carcinogen in the Syrian golden hamster. After a single s.c. treatment, the pancreas was the most affected organ, followed by the liver, respiratory tract, and kidneys. However, repeated application resulted in a higher incidence of neoplasms of the respiratory tract than of the pancreas and kidneys. The effect of N-nitroso-bis(2-acetoxypropyl)amine on toxicity, target tissues, and carcinogenicity was similar to that of N-nitroso-bis(2-hydroxypropyl)amine. The assumption that these two compounds may have similar metabolic pathways was confirmed; N-nitroso-bis(2-acetoxypropyl)amine was readily deesterified to N-nitroso-bis(2-hydroxypropyl)amine in vivo and in vitro.
D000818:Animals; D006224:Cricetinae; D004334:Drug Administration Schedule; D005260:Female; D005706:Gallbladder Neoplasms / Q000139:chemically induced; D007928:Lethal Dose 50; D008113:Liver Neoplasms / Q000139:chemically induced; D008297:Male; D008647:Mesocricetus; D009374:Neoplasms, Experimental / Q000139:chemically induced; D009602:Nitrosamines / Q000378:metabolism / Q000633:toxicity*; D010190:Pancreatic Neoplasms / Q000139:chemically induced*; D011437:Propylamines / Q000378:metabolism / Q000633:toxicity; D012142:Respiratory Tract Neoplasms / Q000139:chemically induced; D014566:Urogenital System
D009602:Nitrosamines; D011437:Propylamines