title: Lymphatic tissue response in chickens treated with tri-o-tolyl phosphate.
abstract: Indices of immunologic response elicited by tri-o-tolyl phosphate (TOTP) in chickens were investigated. Histopathologic evaluation of lymphatic organs (spleen, cecal tonsil, bursa of Fabricius) and selected immuno-related visceral organs containing lymphatic infiltrations (liver, kidney, duodenum, pancreas) was conducted. Liver and spleen showed a consistent and definite increase of diffuse lymphatic tissue in TOTP-treated animals. Total plasma protein levels of treated animals were increased from 7 to 20% over 4-14 days after TOTP administration. A similar increased pattern was noted in gamma-globulin:albumin ratios of the treated group. The data suggested stimulation of immunologic response in chickens treated with TOTP.
mesh_terms: D000818:Animals; D001798:Blood Proteins / Q000032:analysis; D002645:Chickens; D003408:Cresols / Q000494:pharmacology*; D005260:Female; D008208:Lymphatic System / Q000187:drug effects* / Q000473:pathology; D013997:Time Factors; D014317:Tritolyl Phosphates / Q000494:pharmacology*
chemical_list: D001798:Blood Proteins; D003408:Cresols; D014317:Tritolyl Phosphates