title: [Morphology of coronary heart disease (author's transl)].
abstract: Atherosclerosis and insufficiency of the coronary arteries and their sequelae are summarized in the term "coronary heart disease". For the evaluation of the coronary arteries the knowledge of malformations, variants and supply areas is of importance. Extension and severity of atherosclerosis of the coronary arteries and their insufficiency is being influenced by hyperlipidemia, hypertension and diabetes mellitus. The process of atherosclerosis as a cause of the proliferation of vascular smooth muscle cells in complicated by ulceration, parietal and obliterative thrombosis as well by intramural hemorrhages. Relative ischemia leeds to disseminated cell necrosis; total ischemia causes large myocardial tissue necrosis, called infarction. Localization and extension of infarction and the later scars correspond to the caliber of the obliterated coronary artery and to the significance of the collaterals. Postmortem coronary angiography can detect cause and extension of the damaged cardiac area. Functional significance of chronic coronary heart disease is related to the "critical connective tissue content" of the heart. After surgical treatment qualitative and quantitative morphology may help to explain postoperative cardiac failure.
mesh_terms: D000328:Adult; D000368:Aged; D001158:Arteries / Q000002:abnormalities; D001161:Arteriosclerosis / Q000150:complications / Q000473:pathology; D002908:Chronic Disease; D017023:Coronary Angiography; D003327:Coronary Disease / Q000150:complications / Q000473:pathology*; D003330:Coronary Vessel Anomalies; D003925:Diabetic Angiopathies / Q000473:pathology; D006801:Humans; D006949:Hyperlipidemias / Q000150:complications; D006973:Hypertension / Q000150:complications; D008297:Male; D008875:Middle Aged; D009130:Muscle, Smooth / Q000473:pathology; D009206:Myocardium / Q000473:pathology
vernacular_title: Morphologische Grundlagen der coronaren Herzerkrankung