title: Evaluation of (14C)aminopyrine clearance for determination of gastric mucosal blood flow.
abstract: This study has demonstrated high correlation between the radiometric and spectrophotometric determinations of gastric mucosal aminopyrine clearance. The radiometric method is technically easier, allows a larger number of samples to be determined and is safer to the subject. The clearance of small amounts of [14C]aminopyrine was unaffected by large doses of unlabeled aminopyrine showing that mucosal extraction is not concentration limited. Small amounts of [14C]aminopyrine may provide an excellent tool for examining the role of mucosal blood flow in the pathogenesis of gastric disease in man.
mesh_terms: D000632:Aminopyrine / Q000097:blood*; D000818:Animals; D004285:Dogs; D004347:Drug Interactions; D005753:Gastric Mucosa / Q000098:blood supply*; D006632:Histamine / Q000494:pharmacology; D008657:Metabolic Clearance Rate; D012039:Regional Blood Flow / Q000187:drug effects; D014667:Vasopressins / Q000494:pharmacology
chemical_list: D000632:Aminopyrine; D014667:Vasopressins; D006632:Histamine