Tumor-promoting activity of cigarette tar in rat skin exposed to irradiation.
A threefold increase (P=0.006) in the number of skin tumors induced by beta irradiation was demonstrated in rats after surface applications of cigarette tar. The effect appeared due to a tumor-promoting activity of the cigarette tar rather than to an additive tumorigenic effect of the two agents.
D000818:Animals; D008297:Male; D009374:Neoplasms, Experimental / Q000139:chemically induced; D009381:Neoplasms, Radiation-Induced; D012867:Skin / Q000528:radiation effects*; D012878:Skin Neoplasms / Q000209:etiology*; D012907:Smoking; D013638:Tars / Q000009:adverse effects*
D013638:Tars