title: Chlorampenicol retention on, and penetration into, the rabbit eye.
abstract: The retention of the antibiotic chloramphenicol on, and penetration into, the rabbit eye has been compared following administration in two vehicles. Samples were taken of both aqueous humor and a washing fluid applied to the conjunctival surface and the concentration of 14C-chloramphenicol determined. Greater tear film and aqueous humor drug concentrations, which are effective against many organisms, were found with a vehicle which enhanced retention time on the ocular surfaces.
mesh_terms: D000818:Animals; D001082:Aqueous Humor / Q000378:metabolism; D001881:Borates / Q000008:administration & dosage; D001888:Boric Acids / Q000008:administration & dosage; D003315:Cornea / Q000378:metabolism; D005123:Eye / Q000378:metabolism*; D009883:Ophthalmic Solutions; D014677:Pharmaceutical Vehicles; D011817:Rabbits; D013997:Time Factors
chemical_list: D001881:Borates; D001888:Boric Acids; D009883:Ophthalmic Solutions; D014677:Pharmaceutical Vehicles