Dobutamine for inotropic support during emergence from cardiopulmonary bypass.
Dobutamine, a recently introduced derivative of dopamine, is reported to retain inotropic properties with less pronounced chronotropic and arrhythmogenic effects than isoproterenol. The drug was evaluated in two doses, 5 mug/kg/min and 10 mug/kg/min, in two groups of ten patients each, during emergence from cardiopulmonary bypass. A third group of five patients was studied similarly with isoproterenol, 0.02 mug/kg/min. Cardiac index increased 16 and 28 per cent eith the two doses of dobutamine, respectively, and 9 per cent with isoproterenol. Heart rate, in contrast, increased 6 and 15 per cent with dobutamine (not significant) and 44 per cent with isoproterenol (significant). Dobutamine seemed to associated with fewer arrhythmias than isoproterenol. It is concluded that dobutamine, 5-10 mug/kg/min, is suitable for use during emergence from cardiopulmonary bypass and may possess advantages over isoproterenol.
D000328:Adult; D000368:Aged; D001794:Blood Pressure / Q000187:drug effects; D002315:Cardiopulmonary Bypass; D002395:Catecholamines / Q000494:pharmacology*; D055598:Chemical Phenomena; D002621:Chemistry; D004280:Dobutamine / Q000494:pharmacology*; D005112:Extracorporeal Circulation; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D007545:Isoproterenol / Q000494:pharmacology; D008875:Middle Aged; D009200:Myocardial Contraction / Q000187:drug effects*
D002395:Catecholamines; D004280:Dobutamine; D007545:Isoproterenol