Non-MHC-linked genes in autoimmune diseases.
The gene responsible for the lpr mutation in MRL mice that are prone to systemic lupus erythematosus has been shown to encode the apoptosis-inducing Fas antigen, thus pointing to control of apoptosis as a major regulatory mechanism in autoimmunity. In the non-obese diabetic mouse model for insulin-dependent diabetes, four non-MHC-linked loci have been localized in the murine genome that were found to be associated with successive stages of the disease. These findings should soon have a major impact on our understanding of human autoimmune diseases.
D000818:Animals; D000954:Antigens, Surface / Q000235:genetics; D001327:Autoimmune Diseases / Q000235:genetics*; D002874:Chromosome Mapping; D003922:Diabetes Mellitus, Type 1 / Q000235:genetics; D005803:Genes, Immunoglobulin / Q000276:immunology; D020022:Genetic Predisposition to Disease; D006801:Humans; D051379:Mice; D016688:Mice, Inbred NOD / Q000235:genetics / Q000276:immunology; D008817:Mice, Mutant Strains / Q000235:genetics / Q000276:immunology; D011948:Receptors, Antigen, T-Cell / Q000235:genetics; D019014:fas Receptor
D000954:Antigens, Surface; D011948:Receptors, Antigen, T-Cell; D019014:fas Receptor