Glycodihydrofusidate: biliary excretion and its effect on biliary secretion of the rat.
Glycodihydrofusidate, which has the same detergent properties a bile salts, is excreted almost exclusively by the bile duct after intravenous injection in the rat. As with bile salts, it leads to a significant (P less tthan or equal to 0.05) increase in excretion of lecithins and cholesterol (0.15 mumol lecithin and 0.026 mumol cholesterol per 1 mumol of glycodihydrofusidate excreted). In addition, this drug simulataneously inhibits excretion of both endogenous bile salts and bile pigments.
D000818:Animals; D001646:Bile / Q000378:metabolism*; D001647:Bile Acids and Salts / Q000378:metabolism; D005672:Fusidic Acid / Q000378:metabolism*; D006017:Glycolipids / Q000378:metabolism*; D008099:Liver / Q000378:metabolism; D008297:Male; D051381:Rats
D001647:Bile Acids and Salts; D006017:Glycolipids; D005672:Fusidic Acid