[B-cells in thymic epithelial tumors: phenotype, distribution and relation to the intramedullary B-cell population of the normal thymus].
Immunohistochemical analysis of 26 thymomas and thymic carcinomas revealed the occurrence of two different intratumoral B-cell populations. High numbers of B-lymphocytes with formation of lymphoid follicles were found in the extra-epithelial perivascular spaces of cortical thymomas and well differentiated thymic carcinomas associated with myasthenia gravis. On the other hand, B-cells within the epithelial meshwork frequently occurred in organoid medullary islands of predominantly cortical and cortical thymomas. In their distribution and phenotype, these cells correspond to the intramedullary B-cell population of the normal thymus, reflecting a specific intratumoral B-cell homing dependent on medullary epithelial differentiation.
D015703:Antigens, CD / Q000032:analysis; D016175:B-Lymphocyte Subsets / Q000473:pathology*; D015415:Biomarkers; D006801:Humans; D009157:Myasthenia Gravis / Q000150:complications / Q000276:immunology / Q000473:pathology; D013945:Thymoma / Q000276:immunology / Q000473:pathology*; D013953:Thymus Neoplasms / Q000150:complications / Q000276:immunology / Q000473:pathology*
D015703:Antigens, CD; D015415:Biomarkers
B-Zellen in epithelialen Thymustumoren: Phänotyp, Verteilung und Beziehung zur intramedullären B-Zellpopulation des normalen Thymus.