[Experimental studies to the teratogen effects of virus-induced fever (author's transl)].
Fever was induced in pregnant rabbits at the 9th day of gestation by injection of a heat inactivated virus which had not lost its pyrogenic activity. The mother rabbits were killed on the 29th day of pregnancy, the fetuses taken out and the uteri examined for resorptions. The fetuses were inspected for organ malformations macroscopically and for skeleten malformations microscopically. The results were compared with those of control animals. The rise of temperature up to a maximum 2,1 degrees C above normal temperature resulted in no higher resorption and malformation rate.
D000818:Animals; D000013:Congenital Abnormalities / Q000209:etiology*; D005260:Female; D005327:Fetal Resorption / Q000209:etiology; D005334:Fever / Q000150:complications*; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000150:complications*; D011749:Pyrogens; D011817:Rabbits; D014777:Virus Diseases / Q000150:complications
D011749:Pyrogens
Experimentelle Untersuchungen zur Frage der teratogenen Wirkung von virusinduziertem Fieber