Synthesis and pharmacological properties of derivatives of pyrrolo(3,4-d)pyrimidines and pyrrolo(3,4-b)pyridines (I).
The synthesis of variously substituted pyrrolo[3,4-d]pyrimidines and pyrrolo[3,4-b]pyridines is reported. Some of the compounds act as reducers of the carrageenin edema in the rat and as inhibitors of prostaglandin biosynthesis in a microsomal preparation of bovine seminal vesicles.
D000818:Animals; D004487:Edema / Q000188:drug therapy; D005260:Female; D011453:Prostaglandins / Q000096:biosynthesis; D011725:Pyridines / Q000138:chemical synthesis* / Q000494:pharmacology / Q000627:therapeutic use; D011743:Pyrimidines / Q000138:chemical synthesis* / Q000494:pharmacology / Q000627:therapeutic use; D011758:Pyrroles / Q000138:chemical synthesis*; D051381:Rats
D011453:Prostaglandins; D011725:Pyridines; D011743:Pyrimidines; D011758:Pyrroles