Monoamine oxidase activity decreased in cells lacking hypoxanthine phosphoribosyltransferase activity.
The Lesch-Nyhan syndrome in humans is characterized by lack of hypoxanthine phosphoribosyltransferase activity and neurologic abnormalities that suggest changes in catecholamine metabolism. Monoamine oxidase, which degrades biogenic amines, has decreased activity in noradrenergic murine neuroblastoma cell lines lacking hypoxanthine phosphoribosyltransferase activity and in skin fibroblasts from patients with the Lesch-Nyhan syndrome.
D000293:Adolescent; D000328:Adult; D002394:Catechol O-Methyltransferase / Q000378:metabolism; D002460:Cell Line; D002648:Child; D004299:Dopamine beta-Hydroxylase / Q000378:metabolism; D005260:Female; D005347:Fibroblasts; D006801:Humans; D007041:Hypoxanthine Phosphoribosyltransferase / Q000172:deficiency*; D007926:Lesch-Nyhan Syndrome / Q000201:enzymology*; D008297:Male; D008995:Monoamine Oxidase / Q000378:metabolism*; D009474:Neurons
D004299:Dopamine beta-Hydroxylase; D008995:Monoamine Oxidase; D002394:Catechol O-Methyltransferase; D007041:Hypoxanthine Phosphoribosyltransferase