[The effect of the bronchoalveolar fluid of mice infected with the influenza virus on hematopoietic bone marrow precursors].
The influence of bronchoalveolar washing fluid (BAWF), as well as BAWF cells, obtained from mice infected with influenza virus, on the formation of exogenic spleen colony-forming units (CFUs) of lethally irradiated syngeneic recipients was studied. BAWF and BAWF cells of intact syngeneic mice stimulated the growth of CFUs. BAWF of mice infected with nonpathogenic strain A/PR/8/34 lost its capacity for stimulating the growth of colonies, and BAWF cells greatly suppressed colony formation in the spleen of recipients. The participation of interferon, colony-stimulating factor and the virus itself in the process of the modulation of colony formation is discussed.
D015720:5'-Nucleotidase / Q000032:analysis; D000818:Animals; D001853:Bone Marrow / Q000276:immunology*; D001854:Bone Marrow Cells; D001992:Bronchoalveolar Lavage Fluid / Q000737:chemistry / Q000166:cytology / Q000276:immunology* / Q000382:microbiology; D003114:Colony-Forming Units Assay; D006412:Hematopoietic Stem Cells / Q000166:cytology / Q000276:immunology*; D009980:Influenza A virus / Q000302:isolation & purification / Q000472:pathogenicity; D007372:Interferons / Q000032:analysis; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D009976:Orthomyxoviridae Infections / Q000276:immunology*; D013997:Time Factors
D007372:Interferons; D015720:5'-Nucleotidase
Vliianie bronkhoal'veoliarnoĭ zhidkosti mysheĭ, infitsirovannykh virusom grippa, na kostnomozgovye predshestvenniki gemopoéza.