title: Growth and microvascular development of the uterus during early pregnancy in ewes.
abstract: Growth and microvascular development of the uterus were evaluated for ewes on Days 12, 18, 24, and 30 after mating (3-4 ewes/day; Day 0 = day of mating) in two experiments. In experiment 1, fresh weight and dry weight of gravid uterine horns were increased on Days 24 and 30 after mating, whereas those of nongravid uterine horns were elevated only on Day 30. The increased fresh and dry weights of gravid uterine horns on Day 24 were associated with uterine hyperplasia (increased DNA content). Increased fresh and dry weights of gravid uterine horns on Day 30, however, were associated with hypertrophy (increased RNA:DNA and protein:DNA ratios) of uterine tissues. In experiment 2, vascularity of endometrial tissues was elevated on Days 24 and 30 after mating. In addition, dramatic changes in uterine architecture (increased lumenal diameter and decreased endometrial thickness) and in uterine microvascular development (increased abundance of large microvessels and development of a subepithelial capillary plexus) were observed by Day 24 after mating. Characterization of the patterns of uterine growth and microvascular development will enable us to further define the role of previously reported uterine and conceptus-derived growth and angiogenic factors during early pregnancy.
mesh_terms: D000818:Animals; D004247:DNA / Q000096:biosynthesis; D004717:Endometrium / Q000378:metabolism; D005260:Female; D016018:Least-Squares Analysis; D008833:Microcirculation; D009215:Myometrium / Q000378:metabolism; D009929:Organ Size; D011247:Pregnancy; D011270:Pregnancy, Animal / Q000502:physiology*; D014176:Protein Biosynthesis; D012313:RNA / Q000096:biosynthesis; D012756:Sheep; D014599:Uterus / Q000098:blood supply* / Q000254:growth & development / Q000378:metabolism
chemical_list: D012313:RNA; D004247:DNA