title: Inhibitory effect of medroxyprogesterone acetate on angiogenesis induced by human endometrial cancer.
abstract: OBJECTIVE
  The purpose of this study was to investigate the effect of medroxyprogesterone acetate on angiogenesis induced by endometrial cancer and to elucidate the possible mechanisms by which it inhibits the growth of the cancer.
  
  
  METHODS
  Tumors were obtained from 29 patients with endometrial adenocarcinoma, and angiogenesis was assayed in corneas of white rabbits.
  
  
  RESULTS
  Transplantation of tumor tissues into rabbit corneas induced angiogenesis in 70.4% of the corneas, but their transplantation with a pellet of medroxyprogesterone acetate induced angiogenesis in only 21.5% of the corneas. This compound also inhibited angiogenesis induced by acidic fibroblast growth factor and transforming growth factor-alpha.
  
  
  CONCLUSIONS
  Inhibition of angiogenesis may be one mechanism by which medroxyprogesterone acetate inhibits the growth of endometrial adenocarcinoma, and its inhibition of neovascularization induced by adenocarcinoma may be through its direct action on endothelial cells.
mesh_terms: D000230:Adenocarcinoma / Q000098:blood supply* / Q000473:pathology; D000818:Animals; D003315:Cornea; D016889:Endometrial Neoplasms / Q000098:blood supply* / Q000473:pathology; D005260:Female; D016220:Fibroblast Growth Factor 1 / Q000494:pharmacology; D006801:Humans; D017258:Medroxyprogesterone Acetate / Q000494:pharmacology*; D009368:Neoplasm Transplantation; D009389:Neovascularization, Pathologic; D011817:Rabbits; D016211:Transforming Growth Factor alpha / Q000494:pharmacology
chemical_list: D016211:Transforming Growth Factor alpha; D016220:Fibroblast Growth Factor 1; D017258:Medroxyprogesterone Acetate