Radioprotective effectiveness and toxicity of ATP, AET and serotonin applied individually or simultaneously to mice. II. Dose depending protection by single agents.
The work reported was done as a part of a detailed study on the antiradiation effects of three chemical agents-ATP, AET and serotonin-given individually or simultaneously, the ultimate aim being the identification of an optimally effective and non-toxic dose ratio for the triple combination of protectants. Individual PD50 (protectant dose ensuring 50% survival after lethal irradiation) values were found to be 166 mg/kg and 37 mg/kg for AET and serotonin, respectively. ATP was most effective (45% of 30-day-survival) at 1200 mg/kg in face of a level of X-irradiation above the minimum lethal dose. Some sex differences were observed in protection provided by everyone of the three agents, females being more susceptible to the protective action.
D000255:Adenosine Triphosphate / Q000494:pharmacology*; D000818:Animals; D005260:Female; D051379:Mice; D008810:Mice, Inbred C57BL; D011837:Radiation-Protective Agents / Q000494:pharmacology*; D012701:Serotonin / Q000494:pharmacology*; D012737:Sex Factors; D000338:beta-Aminoethyl Isothiourea / Q000494:pharmacology*
D011837:Radiation-Protective Agents; D000338:beta-Aminoethyl Isothiourea; D012701:Serotonin; D000255:Adenosine Triphosphate