Renal effects of in utero exposure to mercuric chloride in rats.
The transplacental nephrotoxicity of mercuric chloride has been studied in female Sprague-Dawley rats. Mercuric chloride was injected s.c. to rats at the dose of 1 mg/kg during the last 8 gestational days or the whole pregnancy. Both mothers and newborns developed a transient renal dysfunction resulting in an increased urinary excretion of beta 2-microglobulin and albumin. In mothers and their female offspring, these effects were completely reversible and did not influence the subsequent evolution of the renal function. In the male offspring, however, transitory changes in protein excretion were again observed a few months later, concomitantly with an enhanced accumulation of alpha 2u-globulin in the kidney. The transfer of mercury from maternal to fetal tissues was very small. The kidney concentrations of mercury in newborns were more than 300 times lower than in mothers. The barrier role of the placenta is not sufficient to prevent the occurrence of renal effects in the offspring of rats treated with inorganic mercury during pregnancy.
D000510:Alpha-Globulins / Q000378:metabolism / Q000652:urine; D000818:Animals; D005260:Female; D007668:Kidney / Q000187:drug effects* / Q000378:metabolism; D008099:Liver / Q000378:metabolism; D008297:Male; D008431:Maternal-Fetal Exchange / Q000502:physiology*; D008627:Mercuric Chloride / Q000493:pharmacokinetics / Q000633:toxicity*; D008628:Mercury / Q000493:pharmacokinetics; D010920:Placenta / Q000378:metabolism*; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects; D051381:Rats; D017207:Rats, Sprague-Dawley; D001613:beta 2-Microglobulin / Q000652:urine
D000510:Alpha-Globulins; C013803:alpha 2u globulin; C025500:alpha(2)-microglobulin; D001613:beta 2-Microglobulin; D008627:Mercuric Chloride; D008628:Mercury