[Effect of ecdysterone on the metabolism of purine and pyrimidine nucleotides in chicken tissues].
Hormonal amounts (10(-7) M) of ecdysterone phytoecdysteroid have been studied for their effect on the metabolic processes in the chicken tissues. Changes in the blood serum parameters which characterize the state of the integral systems of mineral, lipid, protein and nucleotide metabolism as well as the dynamics of metabolism of nucleic acids and their precursors--purine and pyrimidine nucleotides in the tissues with actively functioning protein-synthesizing system prove that the biological effect of ecdysterone after its introduction to the bird organism manifests both in the non-genome early phase of the action (0-1 h) and in the late genome phase (24-72 h), i.e. in analogy to the time of response to the introduction of classical steroid hormones. It is supposed that polyfunctional early effect of ecdysterone is mediated by its action on one of universal transmembrane signal systems of the cells--adenylate cyclase or polyphosphoinosite one, while the presence of the expressed changes in metabolism of nucleic acids in the late phase unambiguously indicate to its action in the bird organism as that of a typical steroid hormone.
D000818:Animals; D002645:Chickens; D004247:DNA / Q000378:metabolism; D004441:Ecdysterone / Q000494:pharmacology*; D016678:Genome; D007420:Intestine, Large / Q000378:metabolism; D008099:Liver / Q000378:metabolism; D009928:Organ Specificity / Q000502:physiology; D010179:Pancreas / Q000378:metabolism; D011685:Purine Nucleotides / Q000378:metabolism*; D011742:Pyrimidine Nucleotides / Q000378:metabolism*; D012313:RNA / Q000378:metabolism; D013154:Spleen / Q000378:metabolism; D013997:Time Factors
D011685:Purine Nucleotides; D011742:Pyrimidine Nucleotides; D004441:Ecdysterone; D012313:RNA; D004247:DNA
Vliianie ékdisterona na obmen purinovykh i pirimidinovykh nukleotidov v tkaniiakh tsypliat.