Variations in the content of steroid receptors in breast cancer. Comparison between primary tumors and metastatic lesions.
Steroid receptors were determined by the dextran-coated charcoal method in 193 breast cancer patients in different clinical stages of disease. Quantitative estrogen and progesterone values in primary tumors (n = 69) were compared with receptors in regional lymph node metastases (n = 28) and in distant malignant deposits (n = 65). The groups including receptor values from primaries and regional lymph node metastases (n = 15) and from primaries and distant metastatic lesions (n = 16) in the same patients were also analyzed. The obtained results indicated relative stability of both receptors in loco-regional disease, but with a tendency towards lower receptor values in lesions from advanced disease. This tendency is probably caused by the disease progression itself, but the influence of radio- or chemotherapy cannot be excluded.
D001943:Breast Neoplasms / Q000737:chemistry* / Q000473:pathology; D002277:Carcinoma / Q000737:chemistry / Q000556:secondary; D002606:Charcoal; D016009:Chi-Square Distribution; D003911:Dextrans; D005260:Female; D006801:Humans; D008207:Lymphatic Metastasis; D010996:Pleural Effusion / Q000737:chemistry; D011960:Receptors, Estrogen / Q000032:analysis*; D011980:Receptors, Progesterone / Q000032:analysis*; D012878:Skin Neoplasms / Q000737:chemistry / Q000556:secondary
D003911:Dextrans; D011960:Receptors, Estrogen; D011980:Receptors, Progesterone; D002606:Charcoal