title: [Toxicity of etmozine, a new antiarrhythmic agent].
abstract: In tests set up on albino rats, guinea pigs and dogs chronic toxicity of aetmozine--a new antiarrhythmic drug used enterally in a dose of 35 mg/kg for periods of 1.3 and 6 months was studied. With different follow-up periods aetmozine was found not to lower the weight gain of the animals, nor to have any adverse effect on the blood and act as a local irritant. Histopathological changes occurring in the internal organs of the animals are of a reversible nature. Single oral administrations of the drug in a dose of 300 mg/kg at different terms of pregnancy did not produce any embryotoxic or teratogenous effects in rats.
mesh_terms: D000014:Abnormalities, Drug-Induced / Q000453:epidemiology; D000818:Animals; D000889:Anti-Arrhythmia Agents / Q000633:toxicity*; D001769:Blood / Q000187:drug effects; D001777:Blood Coagulation / Q000187:drug effects; D004285:Dogs; D004305:Dose-Response Relationship, Drug; D010064:Embryo Implantation / Q000187:drug effects; D004622:Embryo, Mammalian / Q000187:drug effects; D005260:Female; D006168:Guinea Pigs; D007668:Kidney / Q000187:drug effects; D007928:Lethal Dose 50; D008099:Liver / Q000187:drug effects; D009025:Morpholines / Q000633:toxicity; D009929:Organ Size / Q000187:drug effects; D010640:Phenothiazines / Q000633:toxicity*; D011247:Pregnancy; D051381:Rats; D013997:Time Factors
chemical_list: D000889:Anti-Arrhythmia Agents; D009025:Morpholines; D010640:Phenothiazines
vernacular_title: O toksichnosti novogo protivoaritmicheskogo sredstva étmozina