Piperazine hepatitis.
The first reported case of piperazine toxicity resembling viral hepatitis is described in a 25-year-old woman. The illness, which was severe, occurred after administration of the drug on two separate occasions. The evidence favors a hypersensitivity mechanism rather than a direct toxic effect of piperazine or its metabolites on the liver. The humoral or cellular immune basis for such hypersensitivity has not been elucidated.
D000208:Acute Disease; D000328:Adult; D055598:Chemical Phenomena; D056486:Chemical and Drug Induced Liver Injury / Q000209:etiology* / Q000473:pathology; D002621:Chemistry; D005260:Female; D006801:Humans; D008099:Liver / Q000187:drug effects*; D009349:Nematode Infections / Q000188:drug therapy; D010879:Piperazines / Q000009:adverse effects* / Q000627:therapeutic use
D010879:Piperazines