Bone marrow scanning with 52iron (52Fe). Regeneration and extension of marrow after ablative doses of radiotherapy.
Extensively irradiated patients were studied from 0 to 73 months after irradiation by 52Fe bone marrow scanning. Marrow regeneration was observed in most patients after intervals of 12 months or longer. The degree of recovery was not dose-related and the marrow ablative dose was not defined with doses of 4000-5000 rads. Degree of recovery depended more upon the antomic region and/or sequence of fields treated; the last field treated invariably showed poorer regeneration when recovery was uneven. Active erythropoisis expanded into distal inactive erthropoietic sites from 3-12 months after irradiation and then decreased thereafter. Blood count cytopenias were almost always restricted to the first year after irradiation.
D000293:Adolescent; D000328:Adult; D000368:Aged; D001344:Autopsy; D001772:Blood Cell Count; D001853:Bone Marrow / Q000503:physiopathology / Q000528:radiation effects*; D002648:Child; D004920:Erythropoiesis / Q000528:radiation effects; D005260:Female; D006689:Hodgkin Disease / Q000532:radiotherapy*; D006801:Humans; D007504:Iron Radioisotopes; D008297:Male; D008875:Middle Aged; D011877:Radionuclide Imaging / Q000379:methods; D012038:Regeneration / Q000528:radiation effects*; D012075:Remission, Spontaneous; D013997:Time Factors
D007504:Iron Radioisotopes