title: Myocardial ischemia due to infrarenal aortic cross-clamping during aortic surgery in patients with severe coronary artery disease.
abstract: Hemodynamic measurements were performed and ECG recorded before and shortly after infrarenal aortic cross-clamping during operation for abdominal aortic aneurysm in five patients without evidence of heart disease (group I) and in ten patients with severe coronary artery disease (group II). All patients sustained an increase in systemic arterial pressure. Group I demonstrated a decrease in pulmonary artery, pulmonary capillary wedge (PCW), and central venous pressures when the aorta was clamped, whereas group II demonstrated an increase. The difference in response of the groups is significant (P less than 0.05). All three patients who responded to cross-clamping with increases of 7 mm Hg or greater in PCW demonstrated myocardial ischemia during cross-clamping. None of the values measured prior to cross-clamping predicted with certainty the response to cross-clamping. Sodium nitroprusside reversed the elevation of left ventricular filling pressure in all three patients, and in two patients, relieved evidence of myocardial ischemia concurrently. In the third patient, ventricular irritability was abolished by lidocaine and did not recur. We conclude that infrarenal aortic cross-clamping may cause myocardial ischemia in patients with severe coronary artery disease. This ischemia may be predicted by a rise in PCW at the time of cross-clamping, and vasodilator therapy is indicated in such patients.
mesh_terms: D000368:Aged; D000787:Angina Pectoris / Q000150:complications; D001012:Aorta, Abdominal / Q000601:surgery*; D001014:Aortic Aneurysm / Q000601:surgery; D003327:Coronary Disease / Q000188:drug therapy / Q000209:etiology* / Q000601:surgery; D004562:Electrocardiography; D006333:Heart Failure / Q000150:complications; D006439:Hemodynamics / Q000187:drug effects; D006801:Humans; D006976:Hypertension, Pulmonary / Q000209:etiology; D008012:Lidocaine / Q000627:therapeutic use; D008026:Ligation / Q000009:adverse effects*; D008297:Male; D008875:Middle Aged; D009200:Myocardial Contraction / Q000187:drug effects; D009203:Myocardial Infarction / Q000150:complications; D009599:Nitroprusside / Q000627:therapeutic use; D013514:Surgical Procedures, Operative / Q000009:adverse effects*
chemical_list: D009599:Nitroprusside; D008012:Lidocaine