Different behaviour of inorganic and organic mercury in renal excretion with reference to effects of D-penicillamine.
Inorganic and organic mercury was measured in the red cells, plasma, and urine of five laboratory workers to examine the effect of D-penicillamine. The workers had had no particular exposure to mercurials. Before and during administration of D-penicillamine, inorganic mercury levels in plasma were significantly correlated with those in urine or 24-hour urinary outputs, but no significant correlation was found for organic mercury. Administration of D-penicillamine enhanced 24-hour urinary output to a much greater extent in organic than inorganic mercury. All the organic mercury levels in blood, red cells, and plasma were increased by D-penicillamine. This contrasted with the decrease of inorganic mercury levels in plasma.
D000328:Adult; D005260:Female; D006801:Humans; D007668:Kidney / Q000187:drug effects; D008297:Male; D008628:Mercury / Q000097:blood / Q000652:urine*; D009942:Organometallic Compounds / Q000652:urine; D010396:Penicillamine / Q000494:pharmacology*; D010949:Plasma / Q000032:analysis
D009942:Organometallic Compounds; D008628:Mercury; D010396:Penicillamine