Potentiation of ethanol narcosis by dopamine- and l-DOPA-based isoquinolines.
The isoquinolines, salsolinol and 3-carboxysalsolinol, prolong ethanol-induced narcosis in mice. Pretreatment with carbidopa increases the effect of 3-carboxysalsolinol but not of salsolinol. These results suggest that ethanol sleeping-time potentiation by l-LOPA may involve a partial conversion to the isoquinoline in vivo. A central depressant action of salsolinol or the 3-carboxy analogue is suggested.
D000470:Alkaloids / Q000494:pharmacology*; D000818:Animals; D002230:Carbidopa / Q000494:pharmacology; D004298:Dopamine / Q000494:pharmacology; D004357:Drug Synergism; D000431:Ethanol / Q000494:pharmacology*; D007546:Isoquinolines / Q000494:pharmacology*; D007980:Levodopa / Q000494:pharmacology; D008297:Male; D051379:Mice; D012490:Salsoline Alkaloids; D012890:Sleep / Q000187:drug effects*
D000470:Alkaloids; D007546:Isoquinolines; D012490:Salsoline Alkaloids; D000431:Ethanol; D007980:Levodopa; C011704:carboxysalsolinol; D002230:Carbidopa; D004298:Dopamine