title: Normal diluting capacity in hyponatremic patients. Reset osmostat or a variant of the syndrome of inappropriate antidiuretic hormone secretion.
abstract: Four patients with chronic illnesses and stable hyponatremia and plasma hypotonicity had normal urinary diluting capacity, with excretion of greater than 80% of a standard water load (20 ml/kg) within 4 hours and maintenance of a urine osmolality less than 100 mosmol/kg, during sustained water diuresis. Administration of a chronic salt load did not correct the hyponatremia. However, it was stabilized after treatment of the underlying medical condition. These subjects may represent a true resetting of the osmostat or a variant of the syndrome of inappropriate antidiuretic hormone secretion.
mesh_terms: D000368:Aged; D000437:Alcoholism / Q000503:physiopathology; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D007010:Hyponatremia / Q000175:diagnosis / Q000503:physiopathology*; D007668:Kidney / Q000503:physiopathology*; D007671:Kidney Concentrating Ability; D008297:Male; D008875:Middle Aged; D009994:Osmolar Concentration; D014397:Tuberculosis, Pulmonary / Q000503:physiopathology; D014667:Vasopressins / Q000378:metabolism; D014882:Water-Electrolyte Balance
chemical_list: D014667:Vasopressins