Transmissible gastroenteritis. Mucosal ion transport in acute viral enteritis.
Ion transport in the jejunal mucosa of 14-to 16-day-old piglets with severe diarrhea 40 hr after infection with transmissible gastroenteritis (TGE) virus was studied. In infected pigs Na+ transport failed to respond normally to glucose when studied either in Ussing short-circuited chambers or in suspensions of enterocytes isolated selectively from jejunal villi. Theophylline, 10mM, added to the chambers produced the same brisk electrical responses and increments in net Cl- secretion in tissue from both infected and control groups. A defect in glucose-stimulated Na+ absorption in the acute stage of a viral enteritis has been identified which probably contributes to the impaired lumen-to-extracellular fluid flux of Na+ found previously in the jejunum of intact TGE-infected pigs. The mechanisms causing diarrhea in this invasive viral enteritis differ from those causing toxigenic diarrhea.
D000208:Acute Disease; D000818:Animals; D001692:Biological Transport; D002712:Chlorides / Q000378:metabolism*; D004594:Electrophysiology; D004848:Epithelium / Q000378:metabolism; D005761:Gastroenteritis, Transmissible, of Swine / Q000378:metabolism*; D007413:Intestinal Mucosa / Q000378:metabolism*; D007477:Ions; D007583:Jejunum / Q000378:metabolism / Q000473:pathology; D012964:Sodium / Q000378:metabolism*; D013552:Swine
D002712:Chlorides; D007477:Ions; D012964:Sodium