[Keratin metabolism in the epidermis and hair of mice with experimental diabetes].
An animal trial was performed using mice with streptozotocine-induced diabetes, with investigation of velocity of prekeratin and keratin biosynthesis and degradation using 14C-glycine, and evaluation of the content of -SH and -S-S groups in epidermal prekeratin. It has been found out that velocity of epidermal prekeratin and keratin in diabetic animals is higher than that in healthy group. SS and SH groups ratio in prekeratin in diabetic animals is 10 times as high as that in the control group. In the hair of diabetic mice an increased keratin turnover was observed as compared with the norm. The data testify that experimental diabetes manifests itself in increased intensity of keratin metabolism in epidermis and hair. These results may be used as the criteria in elaboration of non-invasive methods for diabetes diagnosis.
D000818:Animals; D003921:Diabetes Mellitus, Experimental / Q000378:metabolism*; D004220:Disulfides / Q000378:metabolism; D004817:Epidermis / Q000378:metabolism*; D006197:Hair / Q000378:metabolism*; D007633:Keratins / Q000378:metabolism*; D008297:Male; D051379:Mice; D011498:Protein Precursors / Q000378:metabolism; D013438:Sulfhydryl Compounds / Q000378:metabolism
D004220:Disulfides; D011498:Protein Precursors; D013438:Sulfhydryl Compounds; C004818:prekeratin; D007633:Keratins
Metabolizm keratina v épidermise i volosakh mysheĭ s éksperimental'nym diabetom.