T-kininogen, processing and functions.
Studies are presented which indicate that T-kininogen, the acute phase kininogen of the rat, could be a healing protein because of its properties as a cysteine protease inhibitor. Evidence is also presented that mRNA of T-kininogen synthesis may be a function of interleukin 6 production. A regulatory mechanism is postulated by which SH cofactors could determine if T-kinin is released or whether the T-kininogen molecule would remain intact. Evidence is also presented that T-kinin acts through kinin B2 receptors. No specific binding of bradykinin or T-kinin could be detected in rat heart preparations.
D000209:Acute-Phase Proteins / Q000502:physiology; D000595:Amino Acid Sequence; D000818:Animals; D003907:Dexamethasone / Q000494:pharmacology; D015870:Gene Expression / Q000187:drug effects; D015850:Interleukin-6 / Q000235:genetics; D016234:Kallikrein-Kinin System / Q000502:physiology; D007704:Kininogens / Q000235:genetics / Q000378:metabolism / Q000502:physiology*; D007705:Kinins / Q000378:metabolism; D008969:Molecular Sequence Data; D011499:Protein Processing, Post-Translational; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism; D051381:Rats; D014158:Transcription, Genetic
D000209:Acute-Phase Proteins; D015850:Interleukin-6; D007704:Kininogens; D007705:Kinins; D012333:RNA, Messenger; D003907:Dexamethasone