Aflatoxins and kwashiorkor in Durban, South Africa.
The present investigation has indicated that maize seeds stored under various simulated seasonal conditions show a spectrum of fungi that appear as a succession. The aflatoxin-producing fungus, Aspergillus flavus, is favoured by storage conditions of high temperature and humidity (summer and autumn seasons). This coincides with the more frequent admission of children suffering from kwashiorkor at King Edward VIII Hospital in Durban. Aflatoxin analysis was undertaken on 74 children diagnosed at King Edward VIII Hospital in Durban as cases of kwashiorkor, marasmus or underweight (Wellcome classification). The control group consisted of 35 age-matched patients with no symptoms of protein energy malnutrition. Aflatoxins were detected in serum and/or urine from all groups, including the controls. The serum/urine ratio was significantly higher in the kwashiorkor group than in the other groups. The control group, however, had a higher proportion of urine aflatoxins than the kwashiorkor group. These findings were interpreted in terms of impaired liver function in kwashiorkor. Aflatoxins may have a rôle in the pathogenesis of kwashiorkor, although the present findings do not indicate that they are a causal factor.
D000348:Aflatoxins / Q000009:adverse effects* / Q000378:metabolism; D005658:Fungi / Q000302:isolation & purification; D006801:Humans; D007223:Infant; D007732:Kwashiorkor / Q000209:etiology* / Q000378:metabolism; D010865:Pilot Projects; D012621:Seasons; D013019:South Africa; D003313:Zea mays / Q000382:microbiology*
D000348:Aflatoxins