[Changes in rabbit skeletal muscle histone concentration at different periods following denervation].
Dynamics of changes in histone fractions isolated from nuclei of rabbit skeletal muscles after the denervation is investigated by means of ion-exchange chromatography on CM-cellulose and polyacrylamide gel electrophoresis. It is shown that the content of arginine-rich histone fraction F2a1 is significantly increased, and that of lysine-rich histone fraction F1 is decreased on the sixth day after the denervation. Pre-operational injections of actinomycin D prevented these changes. The early suggestion about nervous control of transcription in rabbit skeletal muscles is confirmed.
D000818:Animals; D002467:Cell Nucleus / Q000378:metabolism; D003609:Dactinomycin / Q000494:pharmacology; D006657:Histones / Q000378:metabolism*; D009121:Muscle Denervation; D009132:Muscles / Q000378:metabolism* / Q000648:ultrastructure; D011817:Rabbits
D006657:Histones; D003609:Dactinomycin
Izmenenie soderzhaniia gistonov v skletnoĭ myshtse krolika v raznye sroki posle denervatsii