Use of pharmacokinetics to predict the distribution of pantothenate in dogs.
On the basis of plasma concentrations of pantothen[14C]ate, after its intravenous administration, a three compartment open model was proposed to predict the pharmacokinetics of pantothenate in dogs. The model assumed a central compartment comprising the plasma and other extracellular fluids, and distribution into two other peripheral compartments, one of which included the liver. Elimination of unchanged pantothenate was assumed to occur by metabolism from the compartment which included the liver. Distribution of pantothen[14C]ate from the plasma compartment into the liver compartment was shown to be very rapid; during 10 min after intravenous administration about 80 per cent of the dose had been cleared from the plasma compartment. The model successfully predicted the influence (first pass effect) of the liver on the fraction of an oral dose which reached the peripheral plasma unchanged.
D000284:Administration, Oral; D000818:Animals; D004285:Dogs / Q000097:blood*; D007275:Injections, Intravenous; D010205:Pantothenic Acid / Q000008:administration & dosage / Q000097:blood*
D010205:Pantothenic Acid