Study of the laxative properties of the disodium salt of the sulfuric diester of 3,3-bis-(4-hydroxyphenyl)-7-methyl-2-indolinone (DAN-603 in the rat.
The influence of DAN-603 (disodium salt of sulphuric diester of 3,3-bis-(4-hydroxyphenyl)-7-methyl-2-indolinone) on the propulsive motility of the rat digestive tract was studied by means of indicators (charcoal and pyrvinium pamoate) and radioactive tracers (133BaSO4). The results showed that DAN-603 increases selectively the colon motility without modifying the speed of gastric, intestinal (small intestine) and caecal emptying.
D000818:Animals; D001466:Barium Sulfate; D002400:Cathartics; D002432:Cecum / Q000187:drug effects; D002606:Charcoal; D003106:Colon / Q000187:drug effects; D005260:Female; D005769:Gastrointestinal Motility / Q000187:drug effects*; D007211:Indoles; D010636:Phenols; D011774:Pyrvinium Compounds; D051381:Rats; D013270:Stomach / Q000187:drug effects; D013997:Time Factors
D002400:Cathartics; D007211:Indoles; D010636:Phenols; D011774:Pyrvinium Compounds; D002606:Charcoal; D001466:Barium Sulfate