[Actinomyces streptomycini mutant blocked in streptidine biosynthesis].
Mutant 170 not capable of forming streptidine and streptomycin was obtained using chemical mutagenes. This mutant can produce streptomycin only with suplementation of exogenous streptidine. Experiment with labeled C14-streptidine showed its specific incorporation in streptidine moiety of streptomycin molecule.
D002250:Carbon Radioisotopes; D003470:Culture Media; D003511:Cyclohexanols / Q000096:biosynthesis; D005827:Genetics, Microbial / Q000187:drug effects; D006146:Guanidines / Q000096:biosynthesis*; D006595:Hexosamines; D008967:Molecular Biology / Q000187:drug effects; D009154:Mutation / Q000187:drug effects; D013171:Spores, Bacterial; D013302:Streptomyces / Q000187:drug effects / Q000378:metabolism*; D013307:Streptomycin / Q000037:antagonists & inhibitors / Q000096:biosynthesis; D013997:Time Factors
D002250:Carbon Radioisotopes; D003470:Culture Media; D003511:Cyclohexanols; D006146:Guanidines; D006595:Hexosamines; C005733:streptidine; D013307:Streptomycin
Mutant Actinomyces streptomycini, blokirovannyĭ po biosintezu streptidina