[Madumycin biosynthesis by an Actinomadure flava culture under conditions of varying aeration].
Production of madumycin I and madumycin II by 2 strains of Actinomadure flava 2171 was studied. Intensive aeration was an obligatory condition for the antibiotic biosynthesis. The content of madumycins I and II in the culture fluid depended on the strain, aeration conditions and fermentation cycle. Strain 2171/852 produced maximum amounts of madumycin I and madumycin II by the 2nd--3rd and 5th days of cultivation respectively. Strain 2171/2544 mainly produced madumycin I during the whole period of fermentation.
D000332:Aerobiosis; D000900:Anti-Bacterial Agents / Q000096:biosynthesis*; D003470:Culture Media; D009615:Nocardia / Q000378:metabolism*; D010101:Oxygen Consumption; D013997:Time Factors
D000900:Anti-Bacterial Agents; D003470:Culture Media
Biosintez madumitsina kul'turoĭ Actinomadura flava v usloviiakh razlichnoĭ aératsii