[Cytokines and malignant lymphomas].
Cytokines are potent modulators of the physiological immune response. A number of reactive processes are associated with a deregulation of this cytokine expression. Animal models with transgenic mice or transfection experiments have shown that an autocrine or paracrine pathway might be involved in tumor progression and/or tumorigenesis. The study of cytokine expression in malignant lymphomas showed a heterogeneous expression pattern with a number of cases which quantitatively show indications for a marked deregulation of the cytokine expression. The expression od IL-7 and IL-9 seem to be special features of Hodgkin's disease and large cell anaplastic lymphomas. Transfection experiment with IL-9 into mouse T cells results in an autocrine loop and tumorigenesis of the transfected cells. These tumors share a number of similarities to Hodgkin's disease and large cell anaplastic lymphomas in human.
D000818:Animals; D016207:Cytokines / Q000502:physiology*; D006689:Hodgkin Disease / Q000276:immunology; D006801:Humans; D015851:Interleukin-7 / Q000235:genetics / Q000502:physiology; D016906:Interleukin-9 / Q000235:genetics / Q000502:physiology; D008223:Lymphoma / Q000276:immunology* / Q000473:pathology; D016403:Lymphoma, Large B-Cell, Diffuse / Q000276:immunology / Q000473:pathology; D051379:Mice; D013601:T-Lymphocytes / Q000276:immunology; D014162:Transfection
D016207:Cytokines; D015851:Interleukin-7; D016906:Interleukin-9
Zytokine und maligne Lymphome.