Elevation of serum xanthine oxidase following halothane anesthesia in the rat.
Halothan anesthesia was found to be hapatotoxic in the rat, as demonstrated by a significant elevation of serum xanthine oxidase (SXO) level. SXO appeared to be more sensitive marker of liver damage than serum glutamic oxalacetic transaminase. SXO was found to be elevated also following exposure to relative hypoxia.
D000768:Anesthesia, General / Q000009:adverse effects; D000818:Animals; D001219:Aspartate Aminotransferases / Q000097:blood; D056486:Chemical and Drug Induced Liver Injury; D005260:Female; D006221:Halothane / Q000009:adverse effects*; D000860:Hypoxia / Q000150:complications; D008107:Liver Diseases / Q000097:blood / Q000209:etiology; D008297:Male; D051381:Rats; D014969:Xanthine Oxidase / Q000097:blood*
D014969:Xanthine Oxidase; D001219:Aspartate Aminotransferases; D006221:Halothane