title: Histologic and histochemical changes in the aorta and myocardium of rats under the influence of atherogenic diet and phosphatidylcholine (EPL).
abstract: The prophylactic and therapeutic action of EPL on arteriosclerotic changes induced with fat-rich diet in the aorta and myocardium of white rats was studied. Histologic and histochemical studies showed that EPL administered prophylactically in doses of 280 mg/kg and 900 mg/kg body weight does not significantly inhibit development of arteriosclerotic lesions if fat-rich diet is continued. A distinct prophylactic action of EPL was first seen at a dosage of 2800 mg/kg. The therapeutic action of EPL on pathologic changes in the blood vessels also depends on dosage. The higher the dosage of EPL, the less pronounced the changes. At a dosage level of 2800 mg/kg, changes are slight and sporadic.
mesh_terms: D000818:Animals; D001011:Aorta / Q000201:enzymology / Q000473:pathology*; D001161:Arteriosclerosis / Q000517:prevention & control*; D004036:Diet, Atherogenic; D004195:Disease Models, Animal; D004305:Dose-Response Relationship, Drug; D005260:Female; D006651:Histocytochemistry; D008297:Male; D009206:Myocardium / Q000201:enzymology / Q000473:pathology*; D010088:Oxidoreductases / Q000378:metabolism; D010713:Phosphatidylcholines / Q000008:administration & dosage / Q000627:therapeutic use*; D051381:Rats
chemical_list: D010713:Phosphatidylcholines; D010088:Oxidoreductases