Factor IX deficiency in Gaucher disease. An in vitro phenomenon.
Low factor IX coagulant activity was demonstrated in a patient with Gaucher disease before and after splenectomy. The same abnormality was found in seven of ten additional patients studied. Possibly, abnormally retained sphingolipids inactivate or interfere with the action of certain procoagulants.
D001780:Blood Coagulation Tests; D005164:Factor IX / Q000627:therapeutic use; D005776:Gaucher Disease / Q000097:blood* / Q000235:genetics; D002836:Hemophilia B / Q000097:blood* / Q000188:drug therapy; D006801:Humans; D008297:Male; D008875:Middle Aged; D013156:Splenectomy
D005164:Factor IX