title: Solvent-dependent conformational system in hydroxyureas detected by NMR spectroscopy.
abstract: The proton magnetic resonance spectra of the antileukemia agent hydroxyurea and substituted hydroxyureas in several solvents were recorded and correlated with structural features. Solvent-dependent differences in conformational preferences due to effects on internal hydrogen bonding, a temperature-dependent conformational feature, anthe exchangeability of protons with deuterium oxide and acetone-d6 were observed. The conformational features consistent with the spectral data are discussed.
mesh_terms: D055598:Chemical Phenomena; D002621:Chemistry; D006918:Hydroxyurea / Q000031:analogs & derivatives / Q000032:analysis*; D008024:Ligands; D008055:Lipids; D009682:Magnetic Resonance Spectroscopy; D008968:Molecular Conformation; D012995:Solubility
chemical_list: D008024:Ligands; D008055:Lipids; D006918:Hydroxyurea