The inactivity of diamphenethide against liver fluke in certain species of mammals.
Diamphenethide is inactive against Fasciola hepatica in the rat, although the free amine is active. Extracts of rat liver failed to deacetylate diamphenethide to give the free amine. Diamphenethide is active against fluke in the sheep, less effective in the cow and mouse and not active in the rabbit, even though liver extracts of all four species are capable of liberating the free amine.
D000083:Acetanilides / Q000031:analogs & derivatives*; D000818:Animals; D002417:Cattle; D003957:Diamfenetide / Q000378:metabolism / Q000627:therapeutic use*; D066298:In Vitro Techniques; D008099:Liver / Q000378:metabolism; D051379:Mice; D011817:Rabbits; D051381:Rats; D012756:Sheep
D000083:Acetanilides; D003957:Diamfenetide