Identification and quantitation of hypersensitivity reactions to intravenous anaesthetic agents.
It is not possible to distinguish between direct pharmacological effects and immune-mediated hypersensitivity reactions by clinical observation alone and errors may occur in the absence of laboratory tests. A convenient and simple test is the measurement of plasma complement C3 consumption and conversion in sequential blood samples taken at intervals over the 24 h following an adverse response.
D000530:Alfaxalone Alfadolone Mixture / Q000009:adverse effects; D000771:Anesthesia, Intravenous / Q000009:adverse effects*; D003176:Complement C3 / Q000032:analysis; D004342:Drug Hypersensitivity / Q000209:etiology* / Q000276:immunology; D006801:Humans; D007074:Immunoglobulin G / Q000032:analysis
D003176:Complement C3; D007074:Immunoglobulin G; D000530:Alfaxalone Alfadolone Mixture