[The effect of different types of oral contraceptives upon ovarian function (author's transl)].
An investigation on the influence of different types of oral contraceptives upon serum gonadotropins, estradiol and progesterone was carried out in 10 volunteers. The effect of a change from a normophasic type preparation to a sequential preparation (Ovanon and Kombiquens) and from a combined preparation to a minipill (Neogynon and Exlutona) was studied. Two new 3-phase step-up preparations were also tested. Ovulation was inhibited in each case as the preovulatory LH-peak and the subsequent rise of serum progesterone were found to be missing. The basal LH- and FSH-secretion and serum estradiol were demonstrated to be significantly diminished in the volunteers taking combined and sequential preparations. The release of gonadotropines was not inhibited as much when the 3-phase step-up preparations (SHB 261 AB and SHB 264 AB) were used. When Exlutona was taken, the basal LH-secretion was lower than during the pre- and postovulatory phase of the normal cycle, but follicular development did not appear to be inhibited much as both FSH and estradiol were found to be in the normal range.
D000328:Adult; D003276:Contraceptives, Oral / Q000494:pharmacology*; D004958:Estradiol / Q000097:blood; D004997:Ethinyl Estradiol / Q000494:pharmacology; D005260:Female; D005640:Follicle Stimulating Hormone / Q000097:blood; D006062:Gonadotropins / Q000097:blood; D006801:Humans; D007986:Luteinizing Hormone / Q000097:blood; D008234:Lynestrenol / Q000494:pharmacology; D008535:Megestrol / Q000494:pharmacology; D009644:Norgestrel / Q000494:pharmacology; D010053:Ovary / Q000187:drug effects*; D010919:Placebos; D011374:Progesterone / Q000097:blood
D003276:Contraceptives, Oral; D006062:Gonadotropins; D010919:Placebos; D009644:Norgestrel; D004997:Ethinyl Estradiol; D011374:Progesterone; D004958:Estradiol; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone; D008535:Megestrol; D008234:Lynestrenol
Die Beeinflussung des Ovarialzyklus durch verschiedene Typen hormonaler Kontrazeptiva