[Action of N-nitroso-N-methylbiuret on Penicillium nigricans Thom and the protective effect in UV irradiation].
N-Nitrozo-N-methylbiuret (NMB) in a concentration of 0.2% and exposition for 2,3,4 and 6 hours with the survival rate of the conidia of 4-25% induced slight morphological variation of the griseofulvin-producing organism and increased the variation rate with respect to the antibiotic production by 40-140%. Preliminary treatment of the conidia with NMB decreased the lethal effect of UV-rays approximately by 15-25 times. The protective range with respect to morphological variation was 10 times lower. With an increase in the toxicity of NMB its protective effect in irradiation with UV-light decreased.
D001736:Biureas / Q000494:pharmacology*; D002470:Cell Survival / Q000187:drug effects / Q000528:radiation effects; D004305:Dose-Response Relationship, Drug; D004307:Dose-Response Relationship, Radiation; D014644:Genetic Variation / Q000187:drug effects / Q000528:radiation effects; D006118:Griseofulvin / Q000096:biosynthesis; D009602:Nitrosamines; D009607:Nitrosourea Compounds / Q000494:pharmacology*; D010407:Penicillium / Q000187:drug effects* / Q000528:radiation effects; D011830:Radiation Effects; D012641:Selection, Genetic / Q000528:radiation effects; D013473:Sunscreening Agents / Q000494:pharmacology*; D014466:Ultraviolet Rays
D001736:Biureas; D009602:Nitrosamines; D009607:Nitrosourea Compounds; D013473:Sunscreening Agents; C008654:N-nitroso-N-methylbiuret; D006118:Griseofulvin
Deĭstvie N-nitroso-N-metilbiureta na Penicillium nigricans Thom i éffekt zashchity pri UF-obluchenii