The effects of nitroxynil on the survival, growth and morphology of Fasciola hepatica in sheep.
Groups of sheep were experimentally infected with Fasciola hepatica and treated with nitroxynil at 10 mg/kg given subcutaneously at intervals of up to 70 days later. Effects on fluke burden, weight, morphology, egg production and hatchability were recorded. The results showed that the efficacy of nitroxynil and the occurrence of structurally abnormal flukes were directly proportional to the age of infection at treatment. Treatment also deleteriously affected fluke growth and egg hatchability and reduced faecal egg counts.
D000818:Animals; D005210:Fasciola hepatica / Q000187:drug effects* / Q000254:growth & development / Q000502:physiology; D005211:Fascioliasis / Q000469:parasitology / Q000662:veterinary*; D005243:Feces / Q000469:parasitology; D005260:Female; D008297:Male; D009596:Nitrophenols / Q000494:pharmacology*; D009611:Nitroxinil / Q000494:pharmacology*; D010053:Ovary / Q000187:drug effects; D010270:Parasite Egg Count; D012756:Sheep; D012757:Sheep Diseases / Q000469:parasitology*; D013737:Testis / Q000187:drug effects; D014599:Uterus / Q000187:drug effects
D009596:Nitrophenols; D009611:Nitroxinil