[The monitoring of high risk pregnancies by determination of the estriol-16-glucoronide excretion. I. Methods and normal values (author's transl)].
A thin layer chromatographic method for the specific determination of estriol-16-glucoronide as azo dye is described. With this simple method the estriol excretion during pregnancy can be determined with omission of several steps in the determination such as the hydrolysis or evaporation of solvents. A single determination including the thin layer chromatography takes approximately 40 minutes. Based on 210 single determinations from the urine of pregnant women the normal range of excretion between the 28-42 week of pregnancy is determined. The mean excretion rises from 10.8 mg/24 hours at 28 weeks gestation to 25.8 mg/24 hours at 41 weeks gestation. The excretion of estriol-16-glucoronide is a measure of the estriol synthesis in the fetal-placental unit.
D002855:Chromatography, Thin Layer; D004964:Estriol / Q000031:analogs & derivatives / Q000652:urine*; D005260:Female; D006801:Humans; D008722:Methods; D011247:Pregnancy; D011248:Pregnancy Complications / Q000652:urine*; D013997:Time Factors
D004964:Estriol
Die Uberwachung der Risikoschwangerschaft anhand der Ausscheidung von Ostriol-16-Glucuronid. I. Methodik und Normalwerte