A possible role for oxytocin in sperm transport in the male rabbit.
Administration of methallibure (50 mg/kg body weight, daily) to male rabbits resulted in a 45% reduction in sperm number in ejaculates obtained during the treatment period. Recovery occurred within 48 h after the last dose of methallibure. This decrease in sperm number did not occur when oxytocin (0-2 i.u./kg body weight) was administered simultaneously with methallibure. This suggests that methallibure prevents the release of oxytocin during ejaculation.
D000818:Animals; D008297:Male; D008693:Methallibure / Q000008:administration & dosage / Q000494:pharmacology*; D010121:Oxytocin / Q000494:pharmacology / Q000502:physiology*; D013083:Sperm Transport / Q000187:drug effects; D013890:Thiourea / Q000031:analogs & derivatives*; D013997:Time Factors
D010121:Oxytocin; D013890:Thiourea; D008693:Methallibure