title: Effects of adriamycin on ultrastructure of nucleoli in the heart and liver cells of the rat.
abstract: Ultrastructural studies of the effects of adriamycin on liver and cardiac cell nucleoli of the rat showed that nucleolar segregation occurred within 1 hr after an i.v. injection of a 40-mg/kg dose. Between 3 and 27 hr after this single dose, liver cell nucleoli progressively reverted to a normal ultrastructure. Nucleoli of rat myocardial cells did not recover but underwent further fragmentation, segragation, and conversion to ring-shaped structures. The ultrastructural alterations of myocardial cell nucleoli may represent an important aspect of adriamycin toxicity.
mesh_terms: D000818:Animals; D002466:Cell Nucleolus / Q000187:drug effects* / Q000648:ultrastructure; D004317:Doxorubicin / Q000494:pharmacology*; D008099:Liver / Q000648:ultrastructure; D008297:Male; D009206:Myocardium / Q000648:ultrastructure; D009928:Organ Specificity; D051381:Rats; D013997:Time Factors
chemical_list: D004317:Doxorubicin