[Influence of prednisolone on cells erythroid series in the bone marrow of rabbits immunized with diphtheria toxoid].
The bone marrow reaction to prednisolone showed significant changes after the administration of the antigen: there proved to be a significant reduction of the erythrocyte count, hemoglobin content and of hematocrite. The mean erythrocyte volume increased. Along with this there was a reduction of the number of basophilic and polychromatophilic erythroblasts and an increase in number of proerythroblasts. The degree of depression of the red series of the bone marrow (induced by prednisolone) was much less in case of combined administration of prednisolone and diphtheria toxoid.
D000818:Animals; D001853:Bone Marrow / Q000187:drug effects*; D001854:Bone Marrow Cells; D004168:Diphtheria Toxoid; D004912:Erythrocytes / Q000187:drug effects*; D006400:Hematocrit; D006454:Hemoglobins / Q000032:analysis; D011239:Prednisolone / Q000494:pharmacology*; D011817:Rabbits
D004168:Diphtheria Toxoid; D006454:Hemoglobins; D011239:Prednisolone
Vliianie prednizolona na kletki éritroidnogo riada kostnogo mozga krolikov, immunizirovannykh difteriĭnym anatoksinom