[Neuromorphology and neurochemistry of senile dementias in the light of studies on glial response].
The present study describes a few morphological and neurochemical disturbances in astroglial cells in senile dementia of the Alzheimer type (SDAT). The greatly elevated number of fibrous astrocytes in brain samples with SDAT is observed. The content of glial fibrillar acid protein is elevated in these cells. Glial filaments are detected to surround lipid centers. Moreover, there are deviations in energy metabolism: a profound decrease in the levels of the brain creatine kinase CKBB that is one of the principle ATP-regulation enzyme. It is suggested that there is a relationship between all the disturbances observed in glial cells of SDAT patients. These disturbances are likely to be links of the same process which leads to abnormal brain ageing.
D000544:Alzheimer Disease / Q000378:metabolism* / Q000473:pathology*; D001253:Astrocytes / Q000378:metabolism* / Q000473:pathology* / Q000648:ultrastructure; D001706:Biopsy; D001921:Brain / Q000378:metabolism / Q000473:pathology; D002540:Cerebral Cortex / Q000378:metabolism / Q000473:pathology; D003402:Creatine Kinase / Q000378:metabolism; D006801:Humans; D007150:Immunohistochemistry; D007527:Isoenzymes; D009419:Nerve Tissue Proteins / Q000378:metabolism
D007527:Isoenzymes; D009419:Nerve Tissue Proteins; D003402:Creatine Kinase
Neĭromorfologiia i neĭrokhimiia senil'nykh dementsiĭ v svete izucheniia glial'nykh reaktsii.