Potentiation of the estrogenic activity of stilbestrol by spiro (cyclohexane-1,2'-indan)-1',4-dione.
During the investigation of a series of spiro compounds having approximately similar molecular dimensions to naturally occurring estrogens, the novel compound spiro(cyclohexane-1,2'-indan)-1',4-dione was prepared. The pretreatment of mice with this estrogenically inactive compound was found to potentiate the estrogenic activity of stilbestrol.
D000818:Animals; D001835:Body Weight / Q000187:drug effects; D004054:Diethylstilbestrol / Q000494:pharmacology*; D004357:Drug Synergism; D005260:Female; D007189:Indans / Q000138:chemical synthesis* / Q000494:pharmacology; D007192:Indenes / Q000138:chemical synthesis*; D051379:Mice; D009929:Organ Size / Q000187:drug effects; D013141:Spiro Compounds / Q000138:chemical synthesis* / Q000494:pharmacology; D014599:Uterus / Q000187:drug effects
D007189:Indans; D007192:Indenes; D013141:Spiro Compounds; C012038:spiro(cyclohexane-1,2'-indan)-1',4-dione; D004054:Diethylstilbestrol