Cutaneous histoplasmosis.
Cutaneous lesions as a manifestation of histoplasmosis, primarily a disease of the respiratory system, are rare and most commonly appear secondary to progressive dissemination. A patient with documented progressive, disseminated histoplasmosis, having been treated previously with amphotericin B, presented on a second occasion with cutaneous lesions as the chief complaint. Biopsy and cultures of these lesions were positive for Histoplasma capsulatum. A review of the English literature revealed only 7 reported cases of secondary skin histoplasmosis in the past 20 years. All patients, including the current one, either had diseases associated with depressed immunity or were receiving steroid therapy.
D000328:Adult; D000666:Amphotericin B / Q000627:therapeutic use; D003881:Dermatomycoses / Q000188:drug therapy / Q000473:pathology*; D006660:Histoplasmosis / Q000188:drug therapy / Q000473:pathology*; D006801:Humans; D008172:Lung Diseases, Fungal / Q000188:drug therapy; D008297:Male; D012008:Recurrence
D000666:Amphotericin B