title: Unusual intranuclear filaments in the circulating lymphocytes of patients with multiple sclerosis and optic neuritis.
abstract: Mononuclear cells obtained from the peripheral blood of patients with multiple sclerosis (MS) and optic neuritis (ON) were examined by electron microscopy. Unusual intranuclear filaments identical with the so-called paramyxovirus-like filaments were found in circulating lymphocytes from 5 patients with MS and 3 with ON. They were observed in 0.1 to 0.5% of the mononuclear cells. Electron microscopy of the blood cells from 5 other patients with ON, 3 patients with neurologic diseases other than MS, and 4 normal subjects failed to reveal similar structures. The filaments were also absent from blood cells from blood cells from normal subjects during the process of autolysis.
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D001329:Autolysis / Q000473:pathology; D002467:Cell Nucleus / Q000648:ultrastructure; D005260:Female; D006801:Humans; D008214:Lymphocytes / Q000648:ultrastructure*; D008297:Male; D008854:Microscopy, Electron; D008875:Middle Aged; D009103:Multiple Sclerosis / Q000382:microbiology / Q000473:pathology*; D009902:Optic Neuritis / Q000382:microbiology / Q000473:pathology*; D010252:Paramyxoviridae