[Differentiation of the degree of bioavailability of peroral drug forms of tetracycline hydrochloride in experiments on laboratory animals].
Difference in the levels of bioavailability of 4 types of tetracycline hydrochloride tablets was shown on rabbits and guinea pigs. The rates of the antibiotic absorption into the blood of the laboratory animals and volunteers were the same. Relation between the rate of disintegration of various types of tablets of tetracycline hydrochloride and the antibiotic blood levels in the rabbits after administration of the same tablets was found.
D000284:Administration, Oral; D000818:Animals; D001682:Biological Availability; D001702:Biopharmaceutics; D006168:Guinea Pigs; D006801:Humans; D007408:Intestinal Absorption; D007700:Kinetics; D011817:Rabbits; D013607:Tablets; D013608:Tablets, Enteric-Coated; D013752:Tetracycline / Q000008:administration & dosage* / Q000097:blood; D013997:Time Factors
D013607:Tablets; D013608:Tablets, Enteric-Coated; D013752:Tetracycline
Differentsiatsiia stepeni biodostupnosti peroral'nykh lekarstvennykh form tetratsiklina gidrokhlorida v opytakh na laboratornykh zhivotnykh