title: A relation between HLA antigens and clinical features in patients with acquired valvular heart disease.
abstract: Analysis of the HLA antigen patterns in patients with acquired valvular heart disease showed that antigens A29 and AW30/31 occurred more often in those patients whose valvular disease was not preceeded by a history of rheumatic fever or chorea. Patients with no rheumatic history but with antigen A29 or AW30/31 had clinical features that distinguished them from others with valvular disease--namely, (a) isolated mitral valve disease and (b) the need for surgery, often at an early age, after a relatively short duration of symptoms.
mesh_terms: D000328:Adult; D000367:Age Factors; D000368:Aged; D005260:Female; D006680:HLA Antigens / Q000032:analysis; D006349:Heart Valve Diseases / Q000209:etiology / Q000276:immunology*; D006649:Histocompatibility Antigens / Q000032:analysis; D006801:Humans; D008297:Male; D008875:Middle Aged; D012214:Rheumatic Heart Disease / Q000150:complications / Q000276:immunology
chemical_list: D006680:HLA Antigens; D006649:Histocompatibility Antigens