Evidence for the secretory transport mechanism of intestinal immunoglobulin. The ultrastructural distribution of IgM.
The intracellular localization of IgM in porcine intestinal tissue has been studied by immunoelectron microscopy and immunofluorescence. IgM was demonstrated in vesicles in the cytoplasm of crypt epithelial cells particularly in the supranuclear region. It was also shown in the ergastoplasmic cisternae of plasma cells in the intercryptal lamina propria. The findings are compared with those of a previous similar study on secretory IgA and their implications for possible mechanisms of selective transport are discussed.
D000818:Animals; D001692:Biological Transport; D003593:Cytoplasm / Q000276:immunology / Q000648:ultrastructure; D004847:Epithelial Cells; D004848:Epithelium / Q000276:immunology / Q000648:ultrastructure; D007070:Immunoglobulin A; D007075:Immunoglobulin M / Q000032:analysis*; D007413:Intestinal Mucosa / Q000276:immunology / Q000648:ultrastructure*; D007419:Intestinal Secretions / Q000276:immunology*; D008854:Microscopy, Electron; D008856:Microscopy, Fluorescence; D010950:Plasma Cells / Q000276:immunology / Q000648:ultrastructure; D013552:Swine / Q000276:immunology
D007070:Immunoglobulin A; D007075:Immunoglobulin M