title: Modification of diffusion rates of benzocaine from topical vehicles using sodium salicylate as complexing agent.
abstract: The release of benzocaine from various topical vehicles containing benzocaine, alone and in the presence of a complexing agent, sodium salicylate, was measured at 37 degrees using dialysis through a cellulose membrane. Sodium salicylate had a marked effect on the release of benzocaine, depending upon the the type of vehicle, with the largest increase observed for the water-miscible base, polyethylene glycol (macrogol ointment BPC). The amount of drug released from preparations containing 1% (w/w) and 2% (w/w) benzocaine in this vehicle depended upon the sodium salicylate concentration. Results are discussed in terms of the differing physical properties of the complexes formed.
mesh_terms: D001566:Benzocaine / Q000032:analysis; D003956:Dialysis; D004058:Diffusion; D014677:Pharmaceutical Vehicles; D011092:Polyethylene Glycols; D012459:Salicylates; D012995:Solubility; D013997:Time Factors
chemical_list: D014677:Pharmaceutical Vehicles; D012459:Salicylates; D011092:Polyethylene Glycols; D001566:Benzocaine