Neurovirulence and induction of hydrocephalus with parental, mutant, and revertant strains of measles virus.
The relationship between neurovirulence and induction of hydrocephalus was investigated for a measles virus temperature-sensitive mutant and its revertant. The revertant regained the neurovirulence of the parental strain. At appropriate doses the parental, mutant, and revertant strains induced hydrocephalus.
D000818:Animals; D000831:Animals, Newborn; D001921:Brain / Q000382:microbiology*; D006224:Cricetinae; D006849:Hydrocephalus / Q000209:etiology*; D008459:Measles virus / Q000254:growth & development / Q000472:pathogenicity*; D009154:Mutation; D013696:Temperature; D014774:Virulence