Resistance of Thiobacillus novellus to mitomycin C and rifampicin.
Thiobacillus novellus is highly resistant to mitomycin C and rifampicin. This resistance is not due to insusceptibility of the target molecules to the drugs, since mitomycin C cross-links the DNA and rifampicin inhibits the DNA-dependent RNA polymerase of T. novellus in vitro.
D004269:DNA, Bacterial / Q000378:metabolism; D012321:DNA-Directed RNA Polymerases / Q000378:metabolism; D004352:Drug Resistance, Microbial; D008937:Mitomycins / Q000494:pharmacology*; D012293:Rifampin / Q000494:pharmacology*; D013855:Thiobacillus / Q000187:drug effects* / Q000201:enzymology / Q000378:metabolism
D004269:DNA, Bacterial; D008937:Mitomycins; D012321:DNA-Directed RNA Polymerases; D012293:Rifampin