Antibiotic sensitivity of the yeast and mycelial phases of Histoplasma capsulatum.
Cycloheximide and chloramphenicol in combination have a greater effect on yeast cells of Histoplasma capsulatum than on the mycelial phase of this fungus. In contrast, clotrimazole was found to be more effective against mycelia. Miconazole produced a pronounced effect against both phases wheras tolnaftate was only slightly active. Sulfadiazine and griseofulvin were completely inactive against both phases. The differential sensitivities of the 2 phases of H. capsulatum to various antibiotics can be useful in studying the transition of the dimorphic fungus from 1 phase to the other.
D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D002701:Chloramphenicol / Q000494:pharmacology; D003022:Clotrimazole / Q000494:pharmacology; D003513:Cycloheximide / Q000494:pharmacology; D006658:Histoplasma / Q000187:drug effects* / Q000254:growth & development / Q000378:metabolism; D014047:Tolnaftate / Q000494:pharmacology
D000900:Anti-Bacterial Agents; D014047:Tolnaftate; D002701:Chloramphenicol; D003513:Cycloheximide; D003022:Clotrimazole