Effect of phlorizin on glucose transport in the inner ear.
14C-glucose was used as a tracer to study the effect of phlorizin on glucose transport into perilymph and endolymph. The transport was found to be lowered in phlorizin-injected animals compared with that in normal controls. This inhibitory effect corresponding to a phlorizin-sensitive part of glucose transport was greater in the perilymphatic system than in the endolymphatic system. Pathways which are not affected by phlorizin, are considered to exist in both compartments of perilymph and endolymph.
D000818:Animals; D001693:Biological Transport, Active / Q000187:drug effects; D001786:Blood Glucose / Q000032:analysis; D003864:Depression, Chemical; D007758:Ear, Inner / Q000378:metabolism*; D004710:Endolymph / Q000378:metabolism; D005947:Glucose / Q000134:cerebrospinal fluid / Q000378:metabolism*; D006168:Guinea Pigs; D010498:Perilymph / Q000378:metabolism; D010695:Phlorhizin / Q000494:pharmacology*
D001786:Blood Glucose; D010695:Phlorhizin; D005947:Glucose