Serum immunoreactive gastrin: specificity for rheumatoid arthritis, bimodality of distribution, and failure of effect of anti-inflammatory drugs.
A significant rise in immunoreactive gastrin in a proportion of patients with rheumatoid arthritis is confirmed. Such a rise does not seem to occur in other inflammatory or tissue destructive diseases. The patients with raised immunoreactive gastrin appear to form a separate population but the factors determining this separation remain obscure. Anti-inflammatory drugs, at least during short-term administration have no influence on immunoreactive gastrin concentrations.
D000328:Adult; D000368:Aged; D000893:Anti-Inflammatory Agents / Q000494:pharmacology* / Q000627:therapeutic use; D000941:Antigens / Q000032:analysis*; D001168:Arthritis / Q000276:immunology; D001172:Arthritis, Rheumatoid / Q000097:blood / Q000188:drug therapy / Q000276:immunology*; D005260:Female; D005755:Gastrins / Q000097:blood / Q000276:immunology*; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000276:immunology; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000276:immunology; D010003:Osteoarthritis / Q000276:immunology; D011565:Psoriasis / Q000276:immunology; D011863:Radioimmunoassay / Q000379:methods; D013167:Spondylitis, Ankylosing / Q000276:immunology; D014397:Tuberculosis, Pulmonary / Q000276:immunology
D000893:Anti-Inflammatory Agents; D000941:Antigens; D005755:Gastrins