New concepts in respiratory chain diseases.
Recent advances in mitochondrial cytopathies are reviewed. Particular emphasis is given to diseases related to mitochondrial DNA mutations, a field now encompassing myopathic and encephalopathic syndromes, some more common degenerative disorders, and certain aspects of the aging process. Diseases caused by defective oxidative energy generation now have an important place in human pathology.
D001483:Base Sequence; D002872:Chromosome Deletion; D004252:DNA Mutational Analysis; D004272:DNA, Mitochondrial / Q000235:genetics; D004579:Electron Transport; D006801:Humans; D007223:Infant; D017240:Mitochondrial Myopathies / Q000235:genetics / Q000378:metabolism*; D008969:Molecular Sequence Data; D012313:RNA / Q000235:genetics
D004272:DNA, Mitochondrial; D012313:RNA