title: The action of substance P on mesencephalic reticular and substantia nigral neurones of the rat.
abstract: Extracellular recordings were made from neurones in the mesencephalic reticular formation and substantianigra of the rat which was anaesthetized with urethane 1.5-2 g/kg i.p. Out of 44 cells tested 42 were excited by Substance P applied iontophoretically and in some cases this excitation was rapid. Evidence is presented for Substance P as a putative excitatory transmitter onto reticular and nigral neurones possibly released from primary sensory afferents.
mesh_terms: D000109:Acetylcholine / Q000494:pharmacology; D000818:Animals; D005260:Female; D007478:Iontophoresis; D008564:Membrane Potentials / Q000187:drug effects; D008636:Mesencephalon / Q000187:drug effects*; D051381:Rats; D012154:Reticular Formation / Q000187:drug effects*; D013268:Stimulation, Chemical; D013373:Substance P / Q000494:pharmacology*; D013378:Substantia Nigra / Q000187:drug effects*; D005680:gamma-Aminobutyric Acid / Q000494:pharmacology
chemical_list: D013373:Substance P; D005680:gamma-Aminobutyric Acid; D000109:Acetylcholine