Acquired XO/XY clones in bone marrow of a patient with paroxysmal nocturnal hemoglobinuria (PNH).
Cytogenetic studies showed both 45XO and 46XY clones in the bone marrow of a 76-yr-old male with a 17-yr history of paroxysmal nocturnal hemoglobinuria (PNH). 55Fe incorporation studies demonstrated that both clones involved the hematopoietic stem cells. The loss of the Y chromosome may reflect an aging phenomenon, rather than be related to the PNH.
D000368:Aged; D001853:Bone Marrow / Q000473:pathology*; D001854:Bone Marrow Cells; D002869:Chromosome Aberrations / Q000150:complications* / Q000235:genetics; D025063:Chromosome Disorders; D002999:Clone Cells / Q000473:pathology; D003582:Cytogenetics; D006457:Hemoglobinuria, Paroxysmal / Q000150:complications* / Q000235:genetics; D006801:Humans; D007621:Karyotyping; D008297:Male; D012729:Sex Chromosome Aberrations