Polymorphism of esterase-10 in Mus musculus.
An esterase, esterase-10, in the house mouse, Mus musculus, is specific for esters of 4-methylumbelliferone and exhibits a polymorphism detectable by electrophoresis. Fifteen inbred strains and two outbred strains have been examined for this polymorphism, and two phenotypes, ES-10A and ES-10B, have been observed. Each phenotype manifests itself as a single band of enzyme activity, but under the electrophoretic conditions used the ES-10A phenotype has less anodal electrophoretic mobility than the ES-10B phenotype. In F1 hybrids (C3H/He/LacxC57BL/Gr) a third phenotype was observed, ES-10AB, consisting of three bands of enzyme activity, two of which correspond to the parental forms and the third with intermediate mobility. The triple-band pattern in the F1 hybrids indicates that esterase-10 is a dimeric enzyme protein.
D000818:Animals; D004592:Electrophoresis, Starch Gel; D004950:Esterases / Q000302:isolation & purification; D007527:Isoenzymes / Q000302:isolation & purification; D051379:Mice; D008815:Mice, Inbred Strains; D009928:Organ Specificity; D010641:Phenotype; D011110:Polymorphism, Genetic; D013045:Species Specificity
D007527:Isoenzymes; D004950:Esterases