[Antibiotic interaction with proteolytic enzymes].
The effect of penicillin, tetracycline, aminoglucozide antibiotics and streptomycin on BAEE-esterase activity of trypsin was studied. It was found that benzylpenicillin in amounts of 50, 100 and 300 mg, ampicillin in an amount of 25 mg, methicillin in an amount of 12 mg and tetracycline in an amount of 2.5 mg as calculated per 1 mg of trypsin had no effect in vitro on the esterase activity of the enzyme. Neomycin, kanamycin and streptomycin in amounts of 5, 10, 100 or 300 mg per 1 mg of trypsin catalyzed splitting of BAEE by trypsin. When the antibiotics were added to the bile, its esterase activity increased. Preliminary intramuscular administration of trypsin and kanamycin to the rats had no effect on the ampicillin levels in the blood serum and brain and did not affect the permeability of the hemato-encephalic barrier as compared to the use of trypsin alone.
D000617:Aminoglycosides / Q000494:pharmacology; D000667:Ampicillin / Q000494:pharmacology; D000818:Animals; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D001120:Arginine; D001565:Benzoates; D001646:Bile / Q000187:drug effects; D001702:Biopharmaceutics; D004305:Dose-Response Relationship, Drug; D004347:Drug Interactions; D004789:Enzyme Activation / Q000187:drug effects; D004950:Esterases / Q000494:pharmacology; D007612:Kanamycin / Q000494:pharmacology; D010406:Penicillins / Q000494:pharmacology; D010447:Peptide Hydrolases / Q000494:pharmacology*; D051381:Rats; D013307:Streptomycin / Q000494:pharmacology; D013752:Tetracycline / Q000494:pharmacology; D014357:Trypsin / Q000494:pharmacology
D000617:Aminoglycosides; D000900:Anti-Bacterial Agents; D001565:Benzoates; D010406:Penicillins; D007612:Kanamycin; D000667:Ampicillin; D001120:Arginine; D004950:Esterases; D010447:Peptide Hydrolases; D014357:Trypsin; D013752:Tetracycline; D013307:Streptomycin
K voprosu o vzaimodeĭstvii antibiotikov s proteoliticheskimi fermentami