Gap junctions between human meningioma cells maintained in organ culture.
Intercellular junctions were commonly observed in a human syncitial meningioma maintained in organ culture for up to 44 days in vitro (DIV) using gelatin sponge foam matrices. The junctions were identified as one of three types: desmosomes; tight junctions; or gap junctions. Of the three types, gap junctions were frequently encountered and showed preservation of their characteristic ladder-like substructure. The results suggest that organ culture provides an environment that may facilitate correlation of the structure and function of gap junctions between coupled human meningioma cells.
D001932:Brain Neoplasms / Q000473:pathology*; D046508:Culture Techniques; D003896:Desmosomes; D006801:Humans; D007365:Intercellular Junctions; D008297:Male; D008579:Meningioma / Q000473:pathology*; D008875:Middle Aged; D013997:Time Factors