title: Measurement of proliferating cell nuclear antigen (PCNA) and its clinical application in oral cancers.
abstract: The PCNA score was measured in oral squamous cell carcinoma (SCC), and its relationship to other cell proliferation markers, Ki-67 score, S-phase fraction (SPF), and AgNORs counts was investigated. The PCNA score ranged from 0.4% to 43.5% with an average value of 22.8%, the Ki-67 score ranged from 4.9% to 40% with an average of 24.1%, and the SPF ranged from 0.4% to 32.5% with an average of 12.4%, while AgNORs counts ranged from 2.53/nucleus to 7.03/nucleus with an average of 4.74/nucleus. These four parameters were closely interrelated. There was a significant difference in PCNA score between malignant and nonmalignant lesions, suggesting a difference in growth activity. The mean PCNA score decreased significantly from 20.0% to 8.0% after cancer chemotherapy. The response of cancer cells to anticancer agents may be estimated by consecutive measurement of PCNA, since the PCNA score dropped after treatment in cases showing a favorable prognosis.
mesh_terms: D000941:Antigens / Q000032:analysis; D000951:Antigens, Neoplasm / Q000032:analysis*; D034961:Antigens, Nuclear; D001324:Autoantigens / Q000032:analysis*; D002294:Carcinoma, Squamous Cell / Q000276:immunology / Q000473:pathology*; D005434:Flow Cytometry; D006801:Humans; D007124:Immunoenzyme Techniques; D019394:Ki-67 Antigen; D007972:Leukoplakia, Oral / Q000276:immunology / Q000473:pathology*; D008264:Macrophages / Q000473:pathology; D009061:Mouth Mucosa / Q000276:immunology / Q000473:pathology; D009062:Mouth Neoplasms / Q000276:immunology / Q000473:pathology*; D009363:Neoplasm Proteins / Q000032:analysis; D009687:Nuclear Proteins / Q000032:analysis*; D009697:Nucleolus Organizer Region / Q000648:ultrastructure; D018809:Proliferating Cell Nuclear Antigen; D013194:Staining and Labeling; D013601:T-Lymphocytes / Q000473:pathology
chemical_list: D000941:Antigens; D000951:Antigens, Neoplasm; D034961:Antigens, Nuclear; D001324:Autoantigens; D019394:Ki-67 Antigen; D009363:Neoplasm Proteins; D009687:Nuclear Proteins; D018809:Proliferating Cell Nuclear Antigen; C051963:nucleolar organizer region associated proteins