title: Re-evaluation of the effect of spray adhesives on human chromosomes.
abstract: The possible effects of spray adhesives on human chromosomes were re-examined in several ways by three different laboratories. A total of 3,382 metaphases were analyzed in a blind-coded fashion. The proportion of abnormal cells, including gaps, was similar in both the control (8.2%) and exposed (8.3%) samples. Our findings do not confirm the original investigation in which the proportion of abnormal cells was found to be significantly higher in the exposed group (8.99%) than in the control group (1.65%). In the earlier study, however, blind-coded slides were not employed. These and other studies show no positive evidence of an effect of spray adhesives on human chromosomes.
mesh_terms: D000293:Adolescent; D000336:Aerosols / Q000009:adverse effects*; D002648:Child; D002869:Chromosome Aberrations; D002875:Chromosomes / Q000187:drug effects* / Q000648:ultrastructure; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D008938:Mitosis / Q000187:drug effects; D011247:Pregnancy; D013723:Teratogens
chemical_list: D000336:Aerosols; D013723:Teratogens