Effect of sodium pentosan polysulphate on the thrombogenicity of prothrombin complex concentrates.
The addition of pentosan polysulphate sodium (NaPPS) to thrombogenic prothrombin complex concentrates (PCC) dose-dependently reduces or abolishes thrombus formation in rats in the stasis model acc. to Wessler. However, no reduction of thrombogenicity was found in PCC preparations manufactured in the presence of NaPPS.
D000327:Adsorption; D000818:Animals; D001780:Blood Coagulation Tests; D011232:Chemical Precipitation; D002626:Chemistry, Pharmaceutical; D002852:Chromatography, Ion Exchange; D005164:Factor IX / Q000037:antagonists & inhibitors* / Q000302:isolation & purification / Q000633:toxicity; D005260:Female; D006493:Heparin / Q000633:toxicity; D006801:Humans; D007601:Jugular Veins; D010426:Pentosan Sulfuric Polyester / Q000494:pharmacology*; D011516:Prothrombin / Q000037:antagonists & inhibitors* / Q000302:isolation & purification / Q000633:toxicity; D051381:Rats; D017208:Rats, Wistar; D013924:Thrombophlebitis / Q000139:chemically induced / Q000517:prevention & control*; D013997:Time Factors
D010426:Pentosan Sulfuric Polyester; D011516:Prothrombin; D005164:Factor IX; D006493:Heparin