Immunohistochemical detection of desmosomes in oral squamous cell carcinomas: correlation with differentiation, mode of invasion, and metastatic potential.
An expression of desmosomal glycoprotein 1 (DG 1) was immunohistochemically examined in 77 biopsies and 21 metastatic cervical lymph nodes of oral squamous cell carcinomas (SCC). In the primary tumors the DG 1 expression was significantly reduced at the invasive site of poorly differentiated and highly invasive tumors. In cases of metastases in cervical lymph nodes, the DG 1 staining at the invasive site of the primary tumor was significantly less than that of nonmetastatic cases. The DG 1 expression in the metastatic lymph nodes was as weak as that in the primary tumor. Thus, we suggest that immunohistochemical investigation of DG 1 expression in oral SCC is valuable in predicting tumor behavior.
D002294:Carcinoma, Squamous Cell / Q000737:chemistry / Q000473:pathology / Q000556:secondary / Q000648:ultrastructure*; D015815:Cell Adhesion Molecules / Q000032:analysis*; D002471:Cell Transformation, Neoplastic; D003598:Cytoskeletal Proteins / Q000032:analysis*; D051183:Desmoglein 1; D051180:Desmoplakins; D003896:Desmosomes / Q000737:chemistry / Q000648:ultrastructure*; D006801:Humans; D007124:Immunoenzyme Techniques; D007150:Immunohistochemistry; D007633:Keratins / Q000032:analysis; D008207:Lymphatic Metastasis; D009062:Mouth Neoplasms / Q000737:chemistry / Q000473:pathology / Q000648:ultrastructure*; D009361:Neoplasm Invasiveness; D009367:Neoplasm Staging; D013194:Staining and Labeling
D015815:Cell Adhesion Molecules; D003598:Cytoskeletal Proteins; D051183:Desmoglein 1; D051180:Desmoplakins; D007633:Keratins