title: Slow current changes underlying square shaped potential waves in warmed Aplysia neurones.
abstract: On warming, the regularly firing L11 neurone of Aplysia turns into a bursting-type neurone. The bursts of spikes are produced by slow square waves which can also be obtained at room temperature by adding TTX or Co++. Experiments with slow ramp voltage clamp show that warming induces a negative slope (or negative resistance) on the current-voltage characteristic and very slow current variations (r = 10 to 50 sec) in response to potential changes. The square waves are explained by these two phenomena.
mesh_terms: D000818:Animals; D003035:Cobalt / Q000494:pharmacology; D005724:Ganglia / Q000502:physiology; D006358:Hot Temperature; D008564:Membrane Potentials / Q000187:drug effects; D008974:Mollusca / Q000502:physiology*; D009474:Neurons / Q000187:drug effects / Q000502:physiology*; D012623:Seawater; D013779:Tetrodotoxin / Q000494:pharmacology
chemical_list: D003035:Cobalt; D013779:Tetrodotoxin