Visual detection of carcinoembryonic antigen on surfaces.
An attempt is made to detect carcinoembryonic antigen (CEA) at clinically interesting concentrations by using a simple immunologic surface test. Antibodies to CEA are detected in a direct test at concentrations below 1 ng/ml. The sensitivity of this assay is mainly limited by diffusion to the reacting surface. CEA is detected in an inhibition test at concentrations down to 20 ng/ml. The sensitivity of this inhibition test is limited by the average equilibrium constant in solution of the antibody-antigen reaction.
D000327:Adsorption; D001666:Binding Sites, Antibody; D001667:Binding, Competitive; D006046:Gold; D006801:Humans; D007118:Immunoassay / Q000295:instrumentation; D007204:Indium; D011947:Receptors, Antigen, B-Cell
D011947:Receptors, Antigen, B-Cell; D007204:Indium; D006046:Gold