The HLA system in the families of patients with juvenile diabetes mellitus.
The HLA and Bf genotypes were determined in 10 families with one or more children with JDM. A statistically significant association was found between HLA-D-identity and the chance to present JDM within a sibship. No such association was detectable with the SD antigens. A highly significant increase in the frequency of intra-HLA recombination was also found in these families.
D003922:Diabetes Mellitus, Type 1 / Q000235:genetics / Q000276:immunology*; D006680:HLA Antigens / Q000145:classification; D006649:Histocompatibility Antigens / Q000145:classification; D006801:Humans; D010375:Pedigree; D011995:Recombination, Genetic
D006680:HLA Antigens; D006649:Histocompatibility Antigens