T-cell receptor-major histocompatibility complex genetic interactions in rheumatoid arthritis.
Rheumatoid arthritis (RA) is a complex multifactorial illness. It is proposed that multiple genes involved in immune recognition interact to produce a state of genetic susceptibility for RA. The role of HLA and T-cell receptor and other background genes is discussed, with an emphasis on their role in shaping the T-cell repertoire.
D001172:Arthritis, Rheumatoid / Q000235:genetics* / Q000276:immunology; D000939:Epitopes; D020022:Genetic Predisposition to Disease; D006680:HLA Antigens / Q000235:genetics; D006801:Humans; D008285:Major Histocompatibility Complex / Q000235:genetics*; D008954:Models, Biological; D011110:Polymorphism, Genetic; D011948:Receptors, Antigen, T-Cell / Q000235:genetics*; D012641:Selection, Genetic; D013601:T-Lymphocytes / Q000502:physiology; D013950:Thymus Gland / Q000502:physiology
D000939:Epitopes; D006680:HLA Antigens; D011948:Receptors, Antigen, T-Cell