title: [Effect of aprotinin on fibrosis of nerve sutures].
abstract: Although fibrin-glue has been used in many areas of surgery, it has not become fully established in nerve coaptation. Initially, significant advantages were expected; however, as the fibrin clot dissolved prematurely and gapping occurred, antifibrinolytic substances were added to the glue. Following this procedure, fibroses occurred frequently, which remains a problem. In this study, the influence of aprotinin's fibrosis-inducing effect was investigated. Aprotinin demonstrated no additional fibrosis-promoting effect.
mesh_terms: D000714:Anastomosis, Surgical; D000818:Animals; D007611:Aprotinin / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D005355:Fibrosis; D010525:Peripheral Nerves / Q000187:drug effects* / Q000473:pathology / Q000601:surgery; D051381:Rats; D017208:Rats, Wistar; D012584:Sciatic Nerve / Q000187:drug effects / Q000473:pathology / Q000601:surgery; D013536:Suture Techniques
chemical_list: D007611:Aprotinin
vernacular_title: Der Einfluss von Aprotinin auf die Fibrosierung von Nervennähten.