[Effect of thyrocalcitonin on the recovery processes in adrenaline lesion of the myocardium].
Administration of thyrocalcitonine (TCT) in doses of 0.1 and 1 Un/kg for 14 days prevented the development of myocarditis in rats receiving epinephrine (3 mg/kg) for 4 days reduced the death rate among the animals, increased their body weight and normalized the electrolytes composition in the heart. Given in a dose of 10 Un/kg the drug produced a less pronounced positive effect on the study values in the animals with experimentally-produced epinephrine lesion of the heart. According to the authors this may be occasioned by an intensified secretion of the parathyroid hormone in response to a multiple introduction of large TCT doses to the animals.
D000818:Animals; D001835:Body Weight / Q000187:drug effects; D002116:Calcitonin / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D004837:Epinephrine / Q000633:toxicity*; D006321:Heart / Q000187:drug effects*; D008297:Male; D009206:Myocardium / Q000032:analysis / Q000473:pathology; D009929:Organ Size / Q000187:drug effects; D051381:Rats; D013950:Thymus Gland / Q000187:drug effects; D013997:Time Factors
D002116:Calcitonin; D004837:Epinephrine
Vliianie tirokal'tsitonina na protsessy vosstanovleniia pri adrenalinovom porazhenii miokarda