The effect of 3,3-di-pyridyl-methyl-1-phenyl-2-indolinone on the nerve terminal currents of mouse skeletal muscles.
The effects of 3,3-dipyridyl-methyl-1-phenyl-2-indolinone (DPMPI), a new cognition enhancer, on perineural waveforms were assessed on triangularis sterni nerve-muscle preparations in the mouse. The perineural waveforms were recorded with extracellular electrodes placed in the perineural sheaths of motor nerves. At 64.5 microM, DPMPI decreased the fast potassium current of the nerve terminal. The sodium current, calcium currents and calcium-dependent potassium current of the nerve terminal were not affected. At a greater concentration (215 microM), DPMPI decreased all of the components of the waveforms associated with sodium, potassium and calcium currents. It is concluded that DPMPI affects potassium, as well as sodium currents in the nerve terminal. The effect may contribute to its pharmacological actions on synaptic transmission.
D000818:Animals; D002118:Calcium / Q000502:physiology; D015220:Calcium Channels / Q000187:drug effects / Q000378:metabolism; D004558:Electric Stimulation; D005260:Female; D066298:In Vitro Techniques; D007211:Indoles / Q000494:pharmacology*; D007473:Ion Channels / Q000187:drug effects; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D009132:Muscles / Q000187:drug effects / Q000294:innervation*; D009411:Nerve Endings / Q000187:drug effects*; D015221:Potassium Channels / Q000187:drug effects; D011725:Pyridines / Q000494:pharmacology*; D013569:Synapses / Q000187:drug effects / Q000378:metabolism; D013757:Tetraethylammonium Compounds / Q000494:pharmacology
D015220:Calcium Channels; D007211:Indoles; D007473:Ion Channels; D015221:Potassium Channels; D011725:Pyridines; D013757:Tetraethylammonium Compounds; C061017:linopirdine; D002118:Calcium