Inhibition of cell-mediated cytotoxicity against tumor-associated antigens by suppressor cells from tumor-bearing mice.
Spleen cells from mice bearing primary tumours induced by Moloney strain of murine sarcoma virus (M-MuSV) strongly inhibited the in vitro generation of specific secondary cell-mediated cytotoxic response of spleen cells from M-MusV regressor mice. These suppressor cells were resistant to treatment with anti-theta serum and complement or to X-irradiation. It appeared that suppressor cells may have had a role in limiting the host's immune response against tumor growth.
D000818:Animals; D000951:Antigens, Neoplasm; D003601:Cytotoxicity Tests, Immunologic; D007111:Immunity, Cellular; D051379:Mice; D008810:Mice, Inbred C57BL; D008979:Moloney murine leukemia virus; D012513:Sarcoma, Experimental / Q000276:immunology*; D013154:Spleen / Q000276:immunology*
D000951:Antigens, Neoplasm