[Intrahepatic cholestasis due to N-propyl ajmaline].
In two patients intrahepatic cholestasis and cholestatic liver disease probably due to N-propyl ajmaline were observed. In both cases there was a four-week-interval between the first ingestion of the drug and the onset of jaundice. In one case with rigors there was a temporary rise in temperature and cholestasis. In the other there was a two to three week prodromal period of pruritus and gastro-intestinal symptoms. Both cases were characterised by blood and pronounced tissue eosinophilia in the periportal zones, a marked increase of cholestatic and hepatic cell enzymes, serum bilirubin and cholesterol, a moderate increase in erythrocyte sedimentation rate and absence of leucocytosis. Pathological laboratory findings returned to normal spontaneously within 5 weeks in one case and within two weeks under steroid therapy in the other.
D000328:Adult; D000404:Ajmaline / Q000009:adverse effects* / Q000031:analogs & derivatives; D001706:Biopsy; D002779:Cholestasis / Q000139:chemically induced* / Q000473:pathology; D004802:Eosinophilia / Q000150:complications; D005260:Female; D005334:Fever / Q000139:chemically induced; D006801:Humans; D008099:Liver / Q000473:pathology; D008297:Male; D011537:Pruritus / Q000139:chemically induced; D013997:Time Factors
D000404:Ajmaline
Intrahepatische Cholestase durch N-Propyl-Ajmalin