title: Genotoxicity of heated cooking oil vapors.
abstract: Epidemiological studies of lung cancer in Chinese women indicated that factors other than cigarette smoking are related to lung cancer risk. A case-control study suggested that indoor air pollution, particularly from cooking oil emissions, may be involved. Condensates of volatile emissions from rapeseed and soybean cooking oils were prepared and found to be genotoxic in short-term tests including the Salmonella mutation assay, SV50 forward-mutation assay, and sister-chromatid exchange assay, as well as the micronucleus assay in mouse bone marrow. In contrast, condensates from rapeseed oil with butylated hydroxyanisole or hydrogenated rapeseed oil were not mutagenic, implicating oxidation products as the cause for mutagenicity. Peanut oil and lard condensates were not mutagenic in any assay. The association of exposure to Chinese rapeseed cooking-oil emissions and lung-cancer risk may be related to the mutagenic component of these condensates.
mesh_terms: D016902:Air Pollution, Indoor; D000818:Animals; D010367:Arachis; D001937:Brassica; D002460:Cell Line; D002681:China; D003296:Cooking; D006224:Cricetinae; D003412:Cricetulus; D008042:Linolenic Acids / Q000633:toxicity; D008175:Lung Neoplasms / Q000139:chemically induced; D008297:Male; D051379:Mice; D015162:Micronucleus Tests; D009152:Mutagenicity Tests; D009153:Mutagens / Q000633:toxicity*; D009822:Oils, Volatile / Q000633:toxicity*; D010938:Plant Oils / Q000633:toxicity*; D012486:Salmonella typhimurium / Q000187:drug effects / Q000235:genetics; D012854:Sister Chromatid Exchange; D013024:Soybean Oil / Q000633:toxicity
chemical_list: D008042:Linolenic Acids; D009153:Mutagens; D009822:Oils, Volatile; D010938:Plant Oils; D013024:Soybean Oil