Further observations on postpartum ovarian refractoriness: effect of gonadal stimulation in women receiving bromocryptine.
It has been reported previously that the administration of human menopausal gonadotrophins (HMG) to lactating and non-lactating women from day 5 to day 9 postpartum elicited no significant elevation of urinary oestrogens or serum oestradiol within 15 days after delivery. In order to study further the role of prolactin on this ovarian refractoriness, five women receiving 7-5 mg of bromocryptine (CB-154) daily were given HMG at a dose of 300 iu per day, from day 5 to day 10 post-delivery. In all women serum oestradiol and urinary oestrogens showed no significant elevation within the 2 weeks after delivery. Serum prolactin was elevated in all cases and fell to normal nonpregnant levels immediately after CB-154 was administered. The suggestion that prolactin may possess antigonadotrophic activity at the ovarian level is not supported by the data presented here. The deficient ovarian response to gonadotrophin stimulation could be due to either the intraovarian effect of the high amounts of circulating steroids produced during gestation or to some unknown mechanism.
D001971:Bromocriptine / Q000494:pharmacology*; D004873:Ergolines / Q000494:pharmacology*; D004958:Estradiol / Q000097:blood; D004967:Estrogens / Q000652:urine; D005260:Female; D006801:Humans; D008596:Menotropins / Q000494:pharmacology*; D010053:Ovary / Q000187:drug effects* / Q000502:physiology; D049590:Postpartum Period; D011247:Pregnancy; D011388:Prolactin / Q000097:blood / Q000502:physiology
D004873:Ergolines; D004967:Estrogens; D001971:Bromocriptine; D004958:Estradiol; D008596:Menotropins; D011388:Prolactin