Inhibition by indomethacin and niflumic acid of catecholamine--uptake into rat hypothalamic and striatal synaptosomes.
Niflumic acid and indomethacin showed to be inhibitors of catecholamine--uptake into rat striatal and hypothalamic synaptosomes. Whereas the inhibition by niflumic acid was non-competitive for both amines at similar Ki values, the action of indomethacin displayed differences between areas as well as amines: the potency of inhibition by indomethacin was greater in striatal than in hypothalamic synaptosomes irrespective of the amine; the type of inhibition by indomethacin was non-competitive for norepinephrine, but competitive for dopamine regardless of the brain area.
D000818:Animals; D002395:Catecholamines / Q000378:metabolism*; D003342:Corpus Striatum / Q000648:ultrastructure*; D003864:Depression, Chemical; D007031:Hypothalamus / Q000648:ultrastructure*; D066298:In Vitro Techniques; D007213:Indomethacin / Q000494:pharmacology*; D008297:Male; D009539:Nicotinic Acids / Q000494:pharmacology*; D009544:Niflumic Acid / Q000494:pharmacology*; D051381:Rats; D013574:Synaptosomes / Q000187:drug effects / Q000378:metabolism*
D002395:Catecholamines; D009539:Nicotinic Acids; D009544:Niflumic Acid; D007213:Indomethacin