Application of a simple fluorometric method on absorption of canrenone.
The absorption of canrenone, the major metabolite of spironolactone, was studied by a simple fluorometric method in 30 healthy subjects. Two different pharmaceutical formulations were compared on absorption, and only a negligible difference was found between the micronized and balled-milled form. Canrenone in both formulations was well absorbed, whereas spironolactone absorption was slower. Mattingly's fluorometric assay proved to be a simple method to evaluate the absorption of canrenone.
D002192:Canrenone / Q000008:administration & dosage / Q000097:blood / Q000378:metabolism*; D002214:Capsules; D005470:Fluorometry / Q000379:methods; D006854:Hydrocortisone / Q000378:metabolism; D011245:Pregnadienes / Q000378:metabolism*; D013148:Spironolactone / Q000378:metabolism; D013607:Tablets
D002214:Capsules; D011245:Pregnadienes; D013607:Tablets; D013148:Spironolactone; D002192:Canrenone; D006854:Hydrocortisone