title: Efficacy of antibiotics A204 sodium A28695A, and A204np against Coccidia of rabbits.
abstract: Three polycyclic, polyether, monocarboxylic acid antibiotics produced by and extracted from a strain of Streptomyces albus and designated A204 sodium, A28695A, or A204-np, were specifically tested for activity against hepatic and incidentally against intestinal coccidia of rabbits. All were effective in preventing infections and acceptable to young rabbits when prepared in pelleted feed. Weight gain, however, was not as good as inoculated, medicated rabbits as in noninoculated, nonmedicated controls. No gross pathologic changes were detected except in the livers of inoculated, nonmedicated controls which were severely infected on greatly enlarged. Livers of medicated rabbits were uninfected and normal in appearance and size.
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D003048:Coccidiosis / Q000517:prevention & control / Q000662:veterinary*; D004987:Ethers / Q000627:therapeutic use; D007411:Intestinal Diseases, Parasitic / Q000517:prevention & control / Q000662:veterinary; D008109:Liver Diseases, Parasitic / Q000517:prevention & control / Q000662:veterinary; D011817:Rabbits; D013302:Streptomyces
chemical_list: D000900:Anti-Bacterial Agents; D004987:Ethers