[Change in the sensitivity to methotrexate of neoplastic cells cultivated in the presence of folic acid].
Cultivation of tumour L-cells in the presence of increasing folic acid concentrations led to the rise in the resistance of these cells population to metotrexate. With the subsequent cultivation, when the folic acid concentration was not increased the population of such cells became more sensitive to metotrexate even in comparison with the initial L-cells.
D004305:Dose-Response Relationship, Drug; D005492:Folic Acid / Q000494:pharmacology*; D007739:L Cells / Q000187:drug effects*; D008727:Methotrexate / Q000494:pharmacology*
D005492:Folic Acid; D008727:Methotrexate
Izmenenie chuvstvitel'nosti k metotreksatu opukholevykh kletok, kul'tivirovannykh v prisutstvii folievoĭ kisloty