Differential effects of glucagon on induction of rat liver glucose-6-phosphate dehydrogenase by liver injury and dietary change.
Glucagon effectively prevented the increase in glucose-6-phosphate dehodrogenase activity of rat liver following the administration of a glucose-casein mixture without altering the amount of the diet consumed. However, the increase of the enzyme level in carbon tetrachloride-injured rat liver was virtually insensitive to glucagon. The results obtained gave further evidence for the difference between these two induction mechanisms of glucose-6-phosphate dehydrogenase.
D000818:Animals; D002252:Carbon Tetrachloride Poisoning / Q000201:enzymology; D004032:Diet; D004790:Enzyme Induction / Q000187:drug effects; D005934:Glucagon / Q000494:pharmacology*; D005941:Glucokinase / Q000378:metabolism; D005954:Glucosephosphate Dehydrogenase / Q000096:biosynthesis*; D006593:Hexokinase / Q000378:metabolism; D007527:Isoenzymes / Q000378:metabolism; D008099:Liver / Q000187:drug effects / Q000201:enzymology*; D008112:Liver Glycogen / Q000378:metabolism; D008297:Male; D011770:Pyruvate Kinase / Q000378:metabolism; D051381:Rats
D007527:Isoenzymes; D008112:Liver Glycogen; D005934:Glucagon; D005954:Glucosephosphate Dehydrogenase; D006593:Hexokinase; D005941:Glucokinase; D011770:Pyruvate Kinase