title: Treatment of oral candidiasis in debilitated patients with miconazole--a new potent antifungal drug.
abstract: In 24 patients with advanced malignant diseases, mainly leukaemias and lymphomas, 35 episodes of oral candidiasis were treated with topical application of miconazole. Clinical cures were obtained in 100% of the episodes and mycological cures in 91% of the episodes after a mean treatment time of only 4.9 days, although most of the patients were severely granulocytopenic and were undergoing simultaneous treatment with cytostatics, prednisolone and antibiotics. Miconazole appears to be a remarkably fast-acting, reliable and non-toxic drug in the treatment of oral candidiasis.
mesh_terms: D000287:Administration, Topical; D000293:Adolescent; D000328:Adult; D000368:Aged; D002180:Candidiasis, Oral / Q000150:complications / Q000188:drug therapy*; D004341:Drug Evaluation; D005260:Female; D006801:Humans; D007093:Imidazoles / Q000627:therapeutic use*; D007938:Leukemia / Q000150:complications; D008223:Lymphoma / Q000150:complications; D008297:Male; D008825:Miconazole / Q000008:administration & dosage / Q000627:therapeutic use*; D008875:Middle Aged
chemical_list: D007093:Imidazoles; D008825:Miconazole