Modulation of the immune response by passive antibodies. II. Effects of passive anti-hapten and anti-carrier antibodies on the immune response to a sustained antigenic stimulation.
The present work is an attempt at understanding the modulating effects of passive antibodies on the immune response to a sustained antigenic stimulation. Passive anti-carrier and anti-hapten antibodies were injected 24 h before immunization with the hapten carrier conjugate into guinea pigs subsequently injected intradermally with the carrier alone on days 11 and 23. The results showed that passive anti-carrier antibodies blocked the effects of intradermal injections of carrier, i.e., desensitization and increase of antibody synthesis to the carrier. Passive anti-hapten antibodies did not prevent desensitization and delayed antibody synthesis to the carrier. The mechanisms whereby passive antibodies modulate the response to a sustained antigenic stimulation are discussed.
D000818:Animals; D000906:Antibodies; D000917:Antibody Formation; D000937:Antigen-Antibody Reactions; D002352:Carrier Proteins / Q000276:immunology*; D003888:Desensitization, Immunologic; D005260:Female; D006168:Guinea Pigs; D006241:Haptens; D007112:Immunity, Maternally-Acquired; D013997:Time Factors
D000906:Antibodies; D002352:Carrier Proteins; D006241:Haptens