Effect of metoclopramide in chronic gastric retention after gastric surgery.
The effect of metoclopramide, a stimulant of gastric motility, on gastric emptying was tested in 6 patients with chronic gastric retention after vagotomy and gastric resection, unexplained by mechanical obstruction or stomal ulceration. Gastric emptying was measured using a gamma camera technique and a solid meal labeled with 99mtechnetium-labeled diethylenetriaminepentaacetic acid. Metoclopramide produced a 2.6-fold increase in gastric emptying in the first 90 min after eating the meal, compared to placebo (P less than 0.01). Metoclopramide did not alter gastric emptying in 8 normal volunteers. These data indicate that metoclopramide may be useful in treatment of patients with chronically impaired gastric emptying after gastric surgery.
D000328:Adult; D006801:Humans; D008297:Male; D008787:Metoclopramide / Q000627:therapeutic use*; D008875:Middle Aged; D010919:Placebos; D011178:Postgastrectomy Syndromes / Q000188:drug therapy*; D011877:Radionuclide Imaging; D013272:Stomach Diseases / Q000188:drug therapy*; D014628:Vagotomy
D010919:Placebos; D008787:Metoclopramide