title: Promoting effect of sodium deoxycholate on colon adenocarcinomas in germfree rats.
abstract: The promoting effect of sodium deoxycholate (DC) on colon carcinogenesis was studied in female F344 germfree rats. Animals received intrarectal (ir) instillations of N-methyl-N'-nitro-N-nitrosoguanidine (MNNG) for 4 weeks (total dose, 16 mg/rat), then weekly ir doses of DC (total dose, 3 g/rat); the rats were autopsied 52 weeks after the first injection. DC increased the number of MNNG-induced colon adenocarcinomas. No tumors were in the colons of germfree rats given DC alone. It was concluded that DC (present in high concentrations in human stools) had a promoting effect on colon carcinogenesis in rats.
mesh_terms: D000230:Adenocarcinoma / Q000139:chemically induced*; D000818:Animals; D003110:Colonic Neoplasms / Q000139:chemically induced*; D003840:Deoxycholic Acid / Q000494:pharmacology*; D005260:Female; D008769:Methylnitronitrosoguanidine; D009374:Neoplasms, Experimental / Q000139:chemically induced; D009604:Nitrosoguanidines; D051381:Rats; D011916:Rats, Inbred F344
chemical_list: D009604:Nitrosoguanidines; D003840:Deoxycholic Acid; D008769:Methylnitronitrosoguanidine