Retention and extra-articular spread of intra-articularly injected 90Y silicate.
A study was performed on the retention and distribution of intra-articularly injected colloidal 90Y silicate in 7 patients with rheumatoid arthritis (8 knees). In 5 knees retention was complete within the limits of measuring accuracy, and in the remaining 3, 82-84% was retained. No radioactivity was detected in the liver and heart areas or in the blood samples. The cumulative urine activity was less than 1.8%. In the inguinal lymph nodes, activity was detectable %0.5-2%) in only 3 cases. We conclude that 90Y silicate is a safe radioactive agent for the treatment of knee effusions, provided the limb is strictly immobilized after the injection.
D001172:Arthritis, Rheumatoid / Q000378:metabolism* / Q000532:radiotherapy; D006801:Humans; D007264:Inguinal Canal; D007270:Injections, Intra-Articular; D008198:Lymph Nodes / Q000378:metabolism; D009206:Myocardium / Q000378:metabolism; D012824:Silicic Acid / Q000008:administration & dosage / Q000378:metabolism / Q000652:urine; D015021:Yttrium Radioisotopes / Q000008:administration & dosage / Q000378:metabolism* / Q000627:therapeutic use / Q000652:urine
D015021:Yttrium Radioisotopes; D012824:Silicic Acid