Tris (2,3-dibromopropyl) phosphate: human contact sensitization.
Liquid TBP caused delayed hypersensitivity in human subject maximization tests. It showed a dose/response relationship and is judged a weak to mild sensitizer. Patch testing a pre-sensitized subjects using fabrics containing TBP produced responses varying with the availability of the agent at the fiber surface. It appears improbable that treated textiles affording low TBP availability will cause sensitization.
D000818:Animals; D003877:Dermatitis, Contact / Q000209:etiology*; D004305:Dose-Response Relationship, Drug; D004781:Environmental Exposure; D005260:Female; D006168:Guinea Pigs; D006801:Humans; D006842:Hydrocarbons, Brominated / Q000008:administration & dosage / Q000633:toxicity; D007271:Injections, Intradermal; D008297:Male; D009943:Organophosphorus Compounds / Q000008:administration & dosage / Q000633:toxicity*; D010328:Patch Tests; D013784:Textiles
D006842:Hydrocarbons, Brominated; D009943:Organophosphorus Compounds