Phosphorus-nitrogen compounds XIX: distribution of 32P and effect of an active oncolytic on intracerebral leukemia in rodents.
P,P-Bis(1-aziridinyl)-N-1-adamantylphosphinic amide displayed oncolytic activity against intracerebral and intraperitoneal L-1210 leukemia. Administration of the isotope-labeled compound to rats shows 32P distribution to the brain.
D000218:Adamantane / Q000031:analogs & derivatives* / Q000378:metabolism / Q000627:therapeutic use; D000818:Animals; D000970:Antineoplastic Agents / Q000378:metabolism / Q000627:therapeutic use*; D001921:Brain / Q000378:metabolism; D001952:Bridged-Ring Compounds / Q000031:analogs & derivatives*; D005260:Female; D007939:Leukemia L1210 / Q000188:drug therapy*; D009368:Neoplasm Transplantation; D009943:Organophosphorus Compounds / Q000378:metabolism / Q000627:therapeutic use*; D010761:Phosphorus Radioisotopes; D051381:Rats; D013997:Time Factors; D014184:Transplantation, Homologous
D000970:Antineoplastic Agents; D001952:Bridged-Ring Compounds; D009943:Organophosphorus Compounds; D010761:Phosphorus Radioisotopes; D000218:Adamantane