Studies on the transport of aliphatic glucosides by hamster small intestine in vitro.
It has been found (1) that glucosides with a long alkyl chain (2-18 carbon atoms) as the aglycone can be transported by carrier-mediated processes in the hamster small intestine in vitro, (2) that these glucosides interact with the glucose carrier, and (3) that they compete with glucose and analogs for the binding to the carrier. The are Na+- and phlorizin-insensitive components of uptake for the long chain alkyl glucosides which suggest additional interactions or uptake processes.
D000818:Animals; D001693:Biological Transport, Active; D006224:Cricetinae; D005227:Fatty Acids / Q000378:metabolism* / Q000494:pharmacology; D005690:Galactose / Q000378:metabolism; D005947:Glucose / Q000378:metabolism; D005960:Glucosides / Q000378:metabolism* / Q000494:pharmacology; D006027:Glycosides / Q000378:metabolism*; D066298:In Vitro Techniques; D007413:Intestinal Mucosa / Q000378:metabolism; D007421:Intestine, Small / Q000187:drug effects / Q000378:metabolism*; D007700:Kinetics; D008297:Male; D012964:Sodium / Q000494:pharmacology; D013329:Structure-Activity Relationship
D005227:Fatty Acids; D005960:Glucosides; D006027:Glycosides; D012964:Sodium; D005947:Glucose; D005690:Galactose