Interaction of atropine or methylatropinium with four effects of two cholinergic drugs.
In mice, pilocarpine - or oxotremorine - induced decrease in locomotor activity and increase of the reaction time to pain were antagonized by atropine and not by methylatropinium. Identical doses of atropine and methylatropinium suppressed the antagonism of the cholinergics towards reserpine-induced palpebral ptosis. Cholinergics-induced hypothermia was not clearly antagonized by atropine or methylatropinium.
D000818:Animals; D001285:Atropine / Q000494:pharmacology*; D001286:Atropine Derivatives / Q000494:pharmacology; D001763:Blepharoptosis / Q000139:chemically induced; D004347:Drug Interactions; D005731:Ganglionic Stimulants / Q000494:pharmacology*; D008297:Male; D051379:Mice; D009043:Motor Activity / Q000187:drug effects; D010095:Oxotremorine / Q000494:pharmacology; D010862:Pilocarpine / Q000494:pharmacology; D011930:Reaction Time / Q000187:drug effects; D012110:Reserpine
D001286:Atropine Derivatives; D005731:Ganglionic Stimulants; D010862:Pilocarpine; D010095:Oxotremorine; D001285:Atropine; D012110:Reserpine