title: Toxicology of methyl methacrylate: the rate of disappearance of methyl methacrylate in human blood in vitro.
abstract: 1. The rate of disappearance of methyl methacrylate in blood has been determined using an isotope dilution technique. 2. At a concentration of 10(-4) mol dm(-3), methyl methacrylate disappears with pseudo first order kinetics. 3. The half-life of methyl methacrylate in blood at 37 degrees C lies in the range 20--40 min. 4. The half-life showed no dependence on the age or sex of the blood donor. 5. A major, possibly the only, pathway of metabolism is by hydrolysis to methacrylic acid.
mesh_terms: D000328:Adult; D000367:Age Factors; D000368:Aged; D005260:Female; D006207:Half-Life; D006801:Humans; D007700:Kinetics; D008297:Male; D008768:Methylmethacrylates / Q000378:metabolism* / Q000633:toxicity; D008875:Middle Aged; D012737:Sex Factors
chemical_list: D008768:Methylmethacrylates