title: Morphological changes in tight junctions of Necturus maculosus proximal tubules undergoing saline diuresis.
abstract: Tight junctions between epithelial cells are believed to control the paracellular diffusion of substances across epithelia. Epithelia in which tight junctions are poorly developed display a higher paracellular electrical conductance, while those with extensive tight junctions show lower conductance values. We described here a particular epithelium, that of the proximal tubules of the Necturus kidney, in which the development of the tight junctions varies in parallel with a change of paracellular electrical conductance. In control conditions, tight junctions between epithelial cells of the proximal tubules are more developed than in tubules undergoing saline diuresis, a situation which increases the conductance across the paracellular shunt pathway.
mesh_terms: D000818:Animals; D002462:Cell Membrane / Q000648:ultrastructure; D004231:Diuresis; D005260:Female; D007687:Kidney Tubules, Proximal / Q000648:ultrastructure*; D008297:Male; D012965:Sodium Chloride / Q000494:pharmacology; D014562:Caudata
chemical_list: D012965:Sodium Chloride