d-Amphetamine-induced inhibition of central dopaminergic neurons: mediation by a striato-nigral feedback pathway.
Lesions of the striato-nigral pathways (that is, crus cerebri or vicinity of the tail of the caudate nucleus) markedly attenuate depressant effects of intravenous d-amphetamine on central dopaminergic cell activity. These results, coupled with previous data showing that microiontophoretic application of d-amphetamine directly onto dopaminergic cells does not produce significant slowing, provide direct support for the hypothesis that the depressant effect of d-amphetamine on these cells is mediated through a striato-nigral neuronal feedback loop.
D000200:Action Potentials; D000818:Animals; D002421:Caudate Nucleus / Q000502:physiology; D003342:Corpus Striatum / Q000502:physiology*; D004298:Dopamine / Q000378:metabolism*; D005246:Feedback; D008297:Male; D008636:Mesencephalon / Q000502:physiology; D009434:Neural Pathways / Q000502:physiology; D009474:Neurons / Q000187:drug effects* / Q000502:physiology; D051381:Rats; D011955:Receptors, Drug; D013378:Substantia Nigra / Q000502:physiology*
D011955:Receptors, Drug; D004298:Dopamine