[Several clinic-morphologic aspects and problems concerning the pathogenesis of the Marchiafava-Miche li syndrome (paroxysmal nocturnal hemoglobinuria].
The authors present a broad pathoanatomic picture and concise clinical-laboratory characteristics of Marchiafava-Micheli's disease on the basis of their studies of case record date of 31 patients, data of 13 autopsies and findings of 27 treanobiopsies.  Changes in the organs observed in Marchiafava-Micheli's disease were first of all morphological manifestations of massive intravascular hemolysis and associated with latter complications  The most characteristic pathoanatomic feature was changes in the bone marrow which manifested themselves in hyperplasis of nuclear forms of the red series  and in drastically pronounced disorders of the microcirculation.  Necrobiotic changes in the kidney accompanied by massive hemosiderosis, dystrophic changes in the liver with the development of cirrhosis, inhibition of lymphopoiesiis in the spleen and lymph nodes were detected most often...
D001706:Biopsy; D001853:Bone Marrow / Q000473:pathology*; D006457:Hemoglobinuria, Paroxysmal / Q000175:diagnosis / Q000473:pathology*; D006801:Humans; D007668:Kidney / Q000473:pathology; D008099:Liver / Q000473:pathology; D008198:Lymph Nodes / Q000473:pathology; D013154:Spleen / Q000473:pathology
Nekotorye kliniko-morfologicheskie aspekty i voprosy patogeneza bolezni Markiafavy--Mikeli (paroksizma l'no i nochno i gemoglobinurii)