Fatal pulmonary hypersensitivity reaction to HL-A incompatible blood transfusion:report of a case and review of the literature.
A girl with Thalassemia major reacted to a transfusion of packed red blood cells with increasing respiratory distress until death 12 1/2 hours later. Chills and fever were followed by dry cough, dyspnea, and pulmonary edema. The recipient had lymphocytotoxic antibodies specific for donor leukocyte antigens HL-A11 and possibly W14. At autopsy, the lungs showed pulmonary edema with extensive nonspecific acute alveolar injury. Similar cases in the literature are reviewed.
D000293:Adolescent; D001787:Blood Group Incompatibility / Q000150:complications*; D001803:Blood Transfusion; D005260:Female; D006649:Histocompatibility Antigens; D006801:Humans; D011654:Pulmonary Edema / Q000209:etiology / Q000473:pathology; D012130:Respiratory Hypersensitivity / Q000209:etiology*; D013789:Thalassemia / Q000628:therapy
D006649:Histocompatibility Antigens