title: Synthesis of ovulation-inhibiting compounds; structure-activity relationship.
abstract: We describe the synthesis of some new derivatives of benzo(4, 5)cyclohepta(1, 2-b)thiophene which inhibit ovulation and the secretion of luteinizing hormone (LH) in the rat. We also describe the relationship between the structure and activity of these compounds.
mesh_terms: D000818:Animals; D003276:Contraceptives, Oral / Q000494:pharmacology*; D003280:Contraceptives, Oral, Synthetic / Q000494:pharmacology*; D005260:Female; D010060:Ovulation / Q000187:drug effects*; D051381:Rats; D013329:Structure-Activity Relationship
chemical_list: D003276:Contraceptives, Oral; D003280:Contraceptives, Oral, Synthetic