title: Effect of alcohol on urinary and blood dolichols.
abstract: Alcohol appears to affect dolichol metabolism, as both serum and urinary dolichol concentrations were found to be significantly higher in alcoholics than in social drinkers. Furthermore, acute heavy drinking (5.5 g alcohol/kg body weight during 42 h) increased urinary dolichol excretion significantly, whereas moderate drinking (60 g/day for 10 days) had no effect. Increased urinary dolichol concentrations in alcoholics returned rapidly to normal with a half-life decay of 3 days, whereas increased serum dolichol concentrations did not change during a 7-day observation period. The mechanism behind alcohol-induced alterations in dolichol metabolism remains unclear, but based on our results, it seems likely that serum and urinary dolichols are regulated independently from each other.
mesh_terms: D000428:Alcohol Drinking / Q000378:metabolism; D000435:Alcoholic Intoxication / Q000378:metabolism; D000437:Alcoholism / Q000378:metabolism*; D004286:Dolichols / Q000378:metabolism*; D000431:Ethanol / Q000494:pharmacology*; D005260:Female; D006703:Ill-Housed Persons; D006801:Humans; D008297:Male; D008875:Middle Aged; D013695:Temperance
chemical_list: D004286:Dolichols; D000431:Ethanol