[Comparative findings concerning the effect of elenium and seduxen on the cardiovascular system].
The authors studied the effect of seduxen and elenium on 169 patients, particularly their pulse frequency, arterial pressure, electro- and polycardiogramms in a single administration of the drugs parenterally and in a long-term per os administration. A parenteral introduction of both drugs was accompanied by a slight bradycardial effect. However, high doses of seduxen (0.34--0.5 mg/kg) lead to states of tachycardia. Unlike elenium which did not exert a hypotensive effect, seduxen displayed a mild and in some cases significant hypotensive action.
D000293:Adolescent; D000328:Adult; D001919:Bradycardia / Q000139:chemically induced; D002318:Cardiovascular Diseases / Q000139:chemically induced* / Q000150:complications; D002707:Chlordiazepoxide / Q000009:adverse effects*; D003975:Diazepam / Q000009:adverse effects*; D005260:Female; D006801:Humans; D007022:Hypotension / Q000139:chemically induced; D008297:Male; D001523:Mental Disorders / Q000150:complications / Q000188:drug therapy; D008875:Middle Aged; D009200:Myocardial Contraction; D013610:Tachycardia / Q000139:chemically induced
D002707:Chlordiazepoxide; D003975:Diazepam
Sravnitel'nye dannye o vliianii éleniuma i seduksena na serdechno-sosudistuiu sistemu