Damage of skeletal muscle in rats by immunoglobulins. II. Ultrastructural studies.
An experimental model of the autoimmune process was developed to study the ultrastructural aspects of immunomyopathies. Every type of muscle fibre organelle was affected and the severity of injury increased in direct proportion to time following immunization. It is suggested that ultrastructural methods are useful in studies concerned with the analysis of structural aspects of experimental immunomyopathies.
D000818:Animals; D001327:Autoimmune Diseases / Q000473:pathology*; D005260:Female; D007106:Immune Sera; D007136:Immunoglobulins; D008931:Mitochondria, Muscle / Q000648:ultrastructure; D009124:Muscle Proteins / Q000276:immunology*; D009132:Muscles / Q000648:ultrastructure*; D009135:Muscular Diseases / Q000276:immunology* / Q000473:pathology; D009157:Myasthenia Gravis / Q000276:immunology / Q000473:pathology; D009469:Neuromuscular Junction / Q000648:ultrastructure; D051381:Rats; D011919:Rats, Inbred Strains
D007106:Immune Sera; D007136:Immunoglobulins; D009124:Muscle Proteins