Release of 3H-alpha-methyl-m-tyramine from rat striatum in vitro.
Release of 3H-d-alpha-methyl-m-tyramine (3H-MMTA), a false dopaminergic transmitter, from rat striatum was studied in vitro. After its initial uptake, 3H-MMTA was released by high K+ and by amphetamine. The release requirements were essentially the same as those known to exist for release of dopamine in vitro. These studies indicate that 3H-MMTA might serve as a useful tool with which to study dopamine release mechanisms in vitro.
D000661:Amphetamine / Q000494:pharmacology; D000662:Amphetamines / Q000378:metabolism*; D000818:Animals; D002118:Calcium / Q000494:pharmacology; D005260:Female; D066298:In Vitro Techniques; D011188:Potassium / Q000494:pharmacology; D051381:Rats; D012110:Reserpine / Q000494:pharmacology; D010136:p-Hydroxyamphetamine / Q000378:metabolism*
D000662:Amphetamines; D012110:Reserpine; D000661:Amphetamine; D010136:p-Hydroxyamphetamine; D011188:Potassium; D002118:Calcium