[Transcortin binding capacity in the blood plasma of rats with a growing sarcoma 45].
It was shown that at the 10th day of sarcoma 45 growth the content of transcortine bound and free 11-oxycorticosteroids (11-OCS) in plasma of rat peripheral blood was increased. At the 30th day of the tumor growth the content of total and protein bound 11-OCS was decreased, accordingly by 57 and 61%. Following single hydrocortisone injections in intact rats and rats with sarcoma 45, on the 10th day of its growth, a marked increase in the content of bound 11-OCS was noted, as compared with animals receiving saline solution. On the 20-30th day of the tumor growth such effect was not observed. On the 20-30th day of sarcoma 45 growth 8-9% of the value of exogenic hydrocortisone, bound to blood plasma transcortins in intact rats, were found to be tracortin bound.
D015062:11-Hydroxycorticosteroids / Q000097:blood; D000818:Animals; D005609:Free Radicals; D006854:Hydrocortisone / Q000494:pharmacology; D008297:Male; D011485:Protein Binding / Q000187:drug effects; D051381:Rats; D012513:Sarcoma, Experimental / Q000097:blood*; D013997:Time Factors; D014156:Transcortin / Q000378:metabolism*
D015062:11-Hydroxycorticosteroids; D005609:Free Radicals; D014156:Transcortin; D006854:Hydrocortisone
Sviazyvaiushchaia sposobnost' transkortina v plazme krovi krys pri roste sarkomy 45