title: [Disorders of the protease-antiprotease system of a bronchial washout in patients with bronchiectasis and the means for their correction].
abstract: Patients with bronchiectatic disease show imbalance between the activity of proteolytic enzymes and their inhibitors contained by bronchial wash-out, manifesting in a reduction of the inhibitory potential and a rise of the activity of trypsin-like proteinases. After the standard basic treatment the protease-antiprotease system in bronchial wash-out shows a definite improvement. Endobronchial therapy with contrykal given in a dose of 20-30 thousand ATpE for 5-7 days does not ameliorate imbalance in the protease-antiprotease system in bronchiectatic disease patients as compared to the common basic therapy.
mesh_terms: D000328:Adult; D007611:Aprotinin / Q000008:administration & dosage; D001987:Bronchiectasis / Q000188:drug therapy / Q000201:enzymology* / Q000209:etiology; D001992:Bronchoalveolar Lavage Fluid / Q000201:enzymology*; D002908:Chronic Disease; D004341:Drug Evaluation; D004359:Drug Therapy, Combination; D010450:Endopeptidases / Q000032:analysis*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011480:Protease Inhibitors / Q000032:analysis*
chemical_list: D011480:Protease Inhibitors; D007611:Aprotinin; D010450:Endopeptidases
vernacular_title: Narusheniia sistemy proteazy--antiproteazy bronkhial'nogo smyva u bol'nykh bronkhoéktaticheskoĭ bolezn'iu i puti ikh korrektsii.