[Morphological and immunohistochemical findings on the frequency of intranuclear immunoglobulin inclusions (Dutcher bodies) in malignant B-cell lymphomas].
318 cases of 682 malignant B-cell lymphomas reacted positive for cIg. 66 of them showed Dutcher bodies (DB). DB were found in about 22% of plasmacytomas, 17% of immunocytomas, and in 7.5% of follicular lymphomas and polymorphic centroblastomas, respectively. Regarding only the cIg-positive cases, DB occurred in about 27% of immunocytomas, 20% of follicular lymphomas and 18% of polymorphic centroblastomas. A single case of prolymphocytic leukaemia, centrocytoma, monomorphic centroblastoma, and immunoblastoma each showed also DB. Usually, DB-positive plasmacytomas showed kappa, alpha, and J-chains. The remaining lymphomas mostly expressed kappa, my, and J-chains. In conclusion Dutcher bodies can occur with any cIg-producing B-cell lymphoma. They are not limited to immunocytomas.
D002467:Cell Nucleus / Q000276:immunology* / Q000648:ultrastructure; D006801:Humans; D007144:Immunoglobulin J-Chains / Q000032:analysis; D007137:Immunoglobulin alpha-Chains / Q000032:analysis; D007145:Immunoglobulin kappa-Chains / Q000032:analysis; D007136:Immunoglobulins / Q000032:analysis*; D016393:Lymphoma, B-Cell / Q000276:immunology* / Q000473:pathology*; D008224:Lymphoma, Follicular / Q000276:immunology / Q000473:pathology; D010954:Plasmacytoma / Q000276:immunology / Q000473:pathology
D007144:Immunoglobulin J-Chains; D007137:Immunoglobulin alpha-Chains; D007145:Immunoglobulin kappa-Chains; D007136:Immunoglobulins
Morphologische und immunhistochemische Befunde zur Häufigkeit intranukleärer Immunglobulineinschlüsse (Dutcher bodies) bei malignen B-Zell-Lymphomen.