Structure-function subcompartments of the mammalian cell nucleus as revealed by the electron microscopic affinity cytochemistry.
This electron microscopy review documents the in situ cytochemical localization of important nuclear structures and relates this to the important nuclear functions of RNA transcription and processing. With the help of specific probes (antibodies, nucleic acid probes), a comprehensive picture of nuclear subcompartmentalization is beginning to emerge.
D016475:3T3 Cells / Q000648:ultrastructure; D000818:Animals; D015415:Biomarkers; D002466:Cell Nucleolus / Q000502:physiology / Q000648:ultrastructure; D002467:Cell Nucleus / Q000502:physiology / Q000648:ultrastructure*; D002843:Chromatin / Q000648:ultrastructure; D004247:DNA / Q000032:analysis; D006367:HeLa Cells / Q000648:ultrastructure; D006801:Humans; D051379:Mice; D008854:Microscopy, Electron / Q000379:methods*; D009687:Nuclear Proteins / Q000032:analysis; D012313:RNA / Q000032:analysis; D012323:RNA Processing, Post-Transcriptional; D051381:Rats; D012261:Ribonucleoproteins / Q000032:analysis; D013329:Structure-Activity Relationship; D014158:Transcription, Genetic
D015415:Biomarkers; D002843:Chromatin; D009687:Nuclear Proteins; D012261:Ribonucleoproteins; D012313:RNA; D004247:DNA