[Functional significance of alpha- and beta-adrenoreceptors in structures of the stropallidal system].
Microapplication of noradrenaline, isadrine, phentolamine, and propranole to neuroanal populations of the striatum in curarized unanesthetized rabbits revealed an inhibitory and stimulatory effects of noradrenaline and isadrine. A specific antagonism between alpha- and beta-adrenomimetics and respective alpha- and beta-adrenoblocking agents, was noted. Noradenaline seems to have a very important mediatory function in the adrenergic synapases of the striatum. Existence of alpha- and beta-adrenoreceptors with different functions in different brain areas, is suggested.
D000818:Animals; D001931:Brain Mapping; D002421:Caudate Nucleus / Q000502:physiology; D003342:Corpus Striatum / Q000187:drug effects / Q000502:physiology*; D005917:Globus Pallidus / Q000502:physiology; D007545:Isoproterenol / Q000494:pharmacology; D009434:Neural Pathways; D009638:Norepinephrine / Q000494:pharmacology; D010646:Phentolamine / Q000494:pharmacology; D011433:Propranolol / Q000494:pharmacology; D011699:Putamen / Q000502:physiology; D011817:Rabbits; D011941:Receptors, Adrenergic
D011941:Receptors, Adrenergic; D011433:Propranolol; D007545:Isoproterenol; D009638:Norepinephrine; D010646:Phentolamine
O funktsional'nom znachenii alpha- i beta-adrenoretseptorov v strukturakh striopallidarnoĭ sistemy