Inhibition of ovulation in rats by antagonists to serotonin and by a new tricyclic compound.
The ovulation inhibiting activity in adult rats of the 5HT-antagonists cyproheptadine, mianserin and methysergide is shown. Furthermore the activity of a newly synthetized Cycloheptathiophenederivative, compound 26-921, which inhibits LH-secretion and consequently ovulation, is described.
D000818:Animals; D003508:Cycloheptanes / Q000494:pharmacology*; D003533:Cyproheptadine / Q000494:pharmacology; D005260:Female; D007665:Ketotifen / Q000031:analogs & derivatives; D007986:Luteinizing Hormone / Q000037:antagonists & inhibitors* / Q000097:blood / Q000378:metabolism; D008784:Methysergide / Q000494:pharmacology; D008803:Mianserin / Q000494:pharmacology; D010053:Ovary / Q000187:drug effects*; D010060:Ovulation / Q000187:drug effects*; D010903:Pituitary Gland, Anterior / Q000378:metabolism; D051381:Rats; D012702:Serotonin Antagonists; D013876:Thiophenes / Q000494:pharmacology*
D003508:Cycloheptanes; D012702:Serotonin Antagonists; D013876:Thiophenes; D008803:Mianserin; D003533:Cyproheptadine; C012147:compound 26-921; D007986:Luteinizing Hormone; D007665:Ketotifen; D008784:Methysergide