[Experimental study of the effect of IH764-3, a potent component isolated from salviae milltiorrhize, against pulmonary fibrosis].
IH764-3, an effective component isolated from Salvae milliorrhize (a component of traditional Chinese medicine) was used against pulmonary fibrosis in this study. The results indicated that in the treated group, lung coefficient, surfactant, hydroxyproline content and FGF activity were significantly lower than those in the model group. Electron microscopic observation confirmed that the pulmonary ultrastructure was improved remarkably in the treated group: the proliferation of collagen-forming cells and infiltration of inflammatory cells, collagen and elastic fibers were obviously less. All the results demonstrated that IH764-3 has prophylactic and therapeutic effects on the development of pneumonitis and pulmonary fibrosis.
D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000627:therapeutic use*; D001761:Bleomycin / Q000031:analogs & derivatives; D001992:Bronchoalveolar Lavage Fluid / Q000378:metabolism; D004338:Drug Combinations; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use*; D005346:Fibroblast Growth Factors / Q000378:metabolism; D006909:Hydroxyproline / Q000378:metabolism; D008297:Male; D051379:Mice; D010618:Phenanthrolines / Q000627:therapeutic use*; D010936:Plant Extracts; D011658:Pulmonary Fibrosis / Q000139:chemically induced / Q000188:drug therapy* / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar; D027561:Salvia miltiorrhiza; D013501:Surface-Active Agents / Q000378:metabolism
D000894:Anti-Inflammatory Agents, Non-Steroidal; D004338:Drug Combinations; D004365:Drugs, Chinese Herbal; C079053:IH 764-3; D010618:Phenanthrolines; D010936:Plant Extracts; D013501:Surface-Active Agents; C052656:bleomycin A6; D001761:Bleomycin; C028972:dan-shen root extract; D005346:Fibroblast Growth Factors; D006909:Hydroxyproline