Regulation of lung endothelin content by the glucocorticosteroid budesonide.
Intratracheal instillation of Sephadex beads induced a long-lasting inflammation in the rat lung as seen by an increase in lung weights. Repeated instillation enhanced this reaction and increased lung endothelin-1 content 3.5 times. Budesonide given s.c. abolished these effects and even reduced basal endothelin-1 content by 72%. The tissue content of the sensory neuropeptide neurokinin A were unaffected by both treatments. Endothelin has been proposed to play a part in the pathogenesis of bronchial asthma. If it is so, the ability of budesonide to reduce endothelin-1 content could thus be added to the list of beneficial effects of glucocorticosteroids in these conditions.
D000280:Administration, Inhalation; D000818:Animals; D019819:Budesonide; D003911:Dextrans / Q000494:pharmacology; D016232:Endothelins / Q000378:metabolism*; D005260:Female; D007249:Inflammation; D008168:Lung / Q000187:drug effects / Q000378:metabolism*; D008297:Male; D015288:Neurokinin A / Q000032:analysis; D009929:Organ Size; D011282:Pregnenediones / Q000494:pharmacology*; D051381:Rats; D017207:Rats, Sprague-Dawley
D003911:Dextrans; D016232:Endothelins; D011282:Pregnenediones; D019819:Budesonide; D015288:Neurokinin A; C025614:sephadex