[Study of carnosine complexes with nucleotides by the method of high resolution nuclear magnetic resonance].
It is shown that the formation of a carnosine--nucleotide complex (ATP, ADP, AMP) takes place. The stability of the complex mainly depends on: 1) the staking interaction between the heterocyclic rings of carnosine and nucleotides; 2) the electrostatic interaction between the phosphate groups of nucleotide and the positive charged amino group NH3+ of the beta-alanine part of carnosine. The formation of the hydrogen bond between dipeptide COO- group and N1 or N7 of nucleotide is also possible. The complex stability strongly depends on the charge-state of the components and little on the number of the phosphate groups of nucleotide (ATP greater than or equal to ADP greater than AMP).
D000227:Adenine Nucleotides; D000244:Adenosine Diphosphate; D000249:Adenosine Monophosphate; D000255:Adenosine Triphosphate; D002336:Carnosine; D055598:Chemical Phenomena; D002621:Chemistry; D004151:Dipeptides; D009682:Magnetic Resonance Spectroscopy
D000227:Adenine Nucleotides; D004151:Dipeptides; D000249:Adenosine Monophosphate; D000244:Adenosine Diphosphate; D002336:Carnosine; D000255:Adenosine Triphosphate
Issledovanie kompleksov karnozina s nukleotidami metodom iadernogo magnitnogo rezonansa vysokogo razresheniia