title: Acute leukopenia as an allergic reaction to silver sulfadiazine in burn patients.
abstract: Of 68 burn patients at the University of Wisoncsin Burn Center treated with silver sulfadiazine cream over 2 years, two (about 3%) developed fever and marked leukopenia. The symptoms disappeared 1-2 days after discontinuation of the cream. The two cases are described and possible mechanisms of allergic response to this agent are discussed.
mesh_terms: D000208:Acute Disease; D000287:Administration, Topical; D000328:Adult; D002056:Burns / Q000188:drug therapy*; D004342:Drug Hypersensitivity / Q000209:etiology; D005260:Female; D006801:Humans; D007970:Leukopenia / Q000139:chemically induced*; D008297:Male; D013411:Sulfadiazine / Q000009:adverse effects* / Q000627:therapeutic use
chemical_list: D013411:Sulfadiazine