[Heart preservation by means of hypothermia and hyperbaric oxygenation].
The efficiency of the methods of hypothermia and hyperbaric oxygenation for the preservation of canine hearts was studied. The cardiac function was found to reestablish itself nearly completely after 3 hours of preservation, despite some significant metabolic shifts -- disintegration of oxidation and phosphorylation, activation of lysosomal enzymes, reduction of the store of adenyl macroergs and biogenic amines. Five hours of preservation result in irreversible changes in the heart.
D000109:Acetylcholine / Q000378:metabolism; D000244:Adenosine Diphosphate / Q000378:metabolism; D000249:Adenosine Monophosphate / Q000378:metabolism; D000255:Adenosine Triphosphate / Q000378:metabolism; D000818:Animals; D003080:Cold Temperature; D004285:Dogs; D004837:Epinephrine / Q000378:metabolism; D006321:Heart; D006632:Histamine / Q000378:metabolism; D006931:Hyperbaric Oxygenation; D009206:Myocardium / Q000378:metabolism; D009638:Norepinephrine / Q000378:metabolism; D009926:Organ Preservation / Q000379:methods*; D014021:Tissue Preservation / Q000379:methods*
D000249:Adenosine Monophosphate; D000244:Adenosine Diphosphate; D006632:Histamine; D000255:Adenosine Triphosphate; D000109:Acetylcholine; D009638:Norepinephrine; D004837:Epinephrine
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