C-1' hydrogen abstraction of deoxyribose in DNA strand scission by dynemicin A.
Dynemicin A, which is a hybrid antitumor antibiotic containing anthraquinone and enediyne cores, abstracts the C-1' hydrogen of DNA deoxyribose and then the damaged DNA leads to strand breaks with the formation of 5'- and 3'-phosphate termini. The lesions of C-4' hydrogen also occur at 3' side of G.C base pairs (i. e., 5'-CT and 5'-GA), leading to 5'-phosphate and 3'-phosphoglycolate termini or 4'-hydroxylated abasic sites. The C-1' hydrogen abstraction by dynemicin A is distinct from the preferential C-5' hydrogen abstraction of calicheamicin and neocarzinostatin.
D000880:Anthraquinones / Q000494:pharmacology; D000903:Antibiotics, Antineoplastic / Q000494:pharmacology; D001483:Base Sequence; D001761:Bleomycin; D004247:DNA / Q000737:chemistry* / Q000187:drug effects; D004249:DNA Damage; D003855:Deoxyribose / Q000737:chemistry*; D053281:Enediynes; D008969:Molecular Sequence Data; D015394:Molecular Structure; D017663:Peplomycin
D000880:Anthraquinones; D000903:Antibiotics, Antineoplastic; D053281:Enediynes; D001761:Bleomycin; D003855:Deoxyribose; D017663:Peplomycin; D004247:DNA; C061229:dynemicin A