title: Chronic bifascicular block: evaluation of familial factors.
abstract: We studied whether familial factors are significant in chronic bifascicular block. One hundred thirty-four first- and second-degree relatives of 44 outpatients with chronic bifascicular block were examined. These relatives were studied to ascertain the presence or absence of cardiac disease and conduction defects. A race-, age-, and sex-matched control group (age range, 18 to 65) was randomly chosen from a population of employed volunteers for comparison purposes. The study group had a significantly greater frequency of conduction defects than the control group (24/95 versus 10/95, P less than 0.02). Study group members less than 18 years of age (32 patients) had a similar frequency of conduction defects when compared with patients described in the literature. In study group members older than 65 years, 5 out of 7 had conduction defects, a high frequency. In conclusion, the findings suggest an age-related familial tendency to conduction disease among relatives of patients with chronic bifascicular block.
mesh_terms: D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000368:Aged; D002908:Chronic Disease; D005260:Female; D006327:Heart Block / Q000235:genetics*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010375:Pedigree