title: Hydroxyethyl starch induced acquired von Willebrand's disease.
abstract: Hydroxyethyl starch (HES) (Hespan, DuPont) is a widely used synthetic volume expander which in standard doses of up to 1.5l in 24 h has no significant effect on coagulation (Munsch et al. 1988). However, the data sheet states that in large volumes HES may alter the coagulation mechanism. We now report a case of HES induced acquired von Willebrand's disease (vWD) in which severe bleeding occurred.
mesh_terms: D000328:Adult; D005169:Factor VIII / Q000378:metabolism; D005174:Factor XII / Q000378:metabolism; D006801:Humans; D006895:Hydroxyethyl Starch Derivatives / Q000009:adverse effects*; D008297:Male; D010314:Partial Thromboplastin Time; D014842:von Willebrand Diseases / Q000097:blood / Q000139:chemically induced*
chemical_list: D006895:Hydroxyethyl Starch Derivatives; D005169:Factor VIII; D005174:Factor XII