Enzyme induction by enflurane in man.
Concentrations of 6-beta-hydroxycortisol (6-OHF), a polar metabolite of cortisol formed in the endoplasmic reticulum (microsomes) of the liver, and 17-hydroxycorticosteroids (17-OHCS) were measured in the urines of six healthy adult male volunteers exposed to a mean of 9.6 MAC-hours of enflurane anesthesia as an index of possible enzyme induction. The ratio of 6-OHF to 17-OHCS in 24-hour urine specimens collected five days before anesthesia was compared with the ratio of these metabolites in 24-hour urine specimens collected 16 to 18 hours after anesthesia. The ratio of 6-OHF to 17-OHCS increased markedly in five and decreased slightly in one volunteer following anesthesia. The results indicate that enflurane may cause induction of hepatic microsomal enzymes.
D015065:17-Hydroxycorticosteroids / Q000652:urine; D000328:Adult; D000769:Anesthesia, Inhalation; D004737:Enflurane / Q000494:pharmacology*; D004790:Enzyme Induction / Q000187:drug effects*; D006801:Humans; D006854:Hydrocortisone / Q000031:analogs & derivatives / Q000378:metabolism / Q000652:urine; D008099:Liver / Q000201:enzymology; D008297:Male; D008738:Methyl Ethers / Q000494:pharmacology*; D008862:Microsomes, Liver / Q000201:enzymology; D013760:Tetrahydrocortisol / Q000378:metabolism; D013761:Tetrahydrocortisone / Q000378:metabolism
D015065:17-Hydroxycorticosteroids; D008738:Methyl Ethers; D013761:Tetrahydrocortisone; D013760:Tetrahydrocortisol; D004737:Enflurane; D006854:Hydrocortisone