title: Teratogenicity of patulin and patulin adducts formed with cysteine.
abstract: The mean lethal dose of patulin for the chicken embryo injected in the air cell before incubation was determined to be 68.7 mug and that for the 4-day-old embryo was 2.35 mug. Both patulin (1 to 2 mug/egg) and the reaction mixture between patulin and cysteine (15 to 150 mug of patulin equivalents) were teratogenic to the chicken embryo. At least two ninhydrin-negative and four ninhydrin-positive products were formed during the latter reaction. Our explanation of the reaction mechanism remains to be elaborated.
mesh_terms: D000818:Animals; D002642:Chick Embryo; D003545:Cysteine / Q000378:metabolism; D007928:Lethal Dose 50; D051379:Mice; D010365:Patulin / Q000378:metabolism / Q000633:toxicity*; D011714:Pyrans / Q000633:toxicity*; D013723:Teratogens
chemical_list: D011714:Pyrans; D013723:Teratogens; D010365:Patulin; D003545:Cysteine