Effects of sympathomimetic amines on 45Ca efflux from liver slices.
The efflux of 45Ca from slices of guinea-pig and rabbit liver is greatly increased by alpha-adrenoceptor agonists. Isoprenaline is much less effective. The effects of these agents on the efflux of 45Ca mirror their actions on 42K loss and suggest that the two may be related. Glucose release from both rabbit and guinea-pig liver slices is increased to a similar extent by either alpha- or beta-receptor agonists. The possible relationship between Ca and K movements and the production of glucose is discussed.
D000818:Animals; D002118:Calcium / Q000378:metabolism*; D002132:Calcium Radioisotopes; D004983:Ethanolamines / Q000494:pharmacology; D005947:Glucose / Q000378:metabolism; D006168:Guinea Pigs; D066298:In Vitro Techniques; D007545:Isoproterenol / Q000494:pharmacology; D008099:Liver / Q000187:drug effects / Q000378:metabolism*; D008297:Male; D009638:Norepinephrine / Q000494:pharmacology; D011197:Potassium Radioisotopes; D011817:Rabbits; D013449:Sulfonamides / Q000494:pharmacology; D013566:Sympathomimetics / Q000494:pharmacology*; D013997:Time Factors
D002132:Calcium Radioisotopes; D004983:Ethanolamines; D011197:Potassium Radioisotopes; D013449:Sulfonamides; D013566:Sympathomimetics; D005947:Glucose; D007545:Isoproterenol; D002118:Calcium; D009638:Norepinephrine