Ethanol, indomethacin and gastric acid secretion in the rat.
In the anesthetized rat, 10% ethanol in the gastric lumen causes a total cessation of the secretion of gastric acid within 30--60 min. This effect is inhibited by pretreatment with indomethacin, which is a potent inhibitor of prostaglandin synthesis. Therefore, the inhibitory effect of local ethanol on gastric acid secretion in the rat may be mediated, at least partly, by increased synthesis of prostaglandins.
D000818:Animals; D003864:Depression, Chemical; D000431:Ethanol / Q000494:pharmacology*; D005750:Gastric Juice / Q000378:metabolism*; D007213:Indomethacin / Q000494:pharmacology*; D008297:Male; D051381:Rats; D013997:Time Factors
D000431:Ethanol; D007213:Indomethacin