[In vitro effects of low molecular weight dextran on the surface properties of LDL].
The relative number of free amino groups on the surface of low density lipoproteins (LDL) was determined after the incubation with low molecular weight dextran (MW 40,000) in several concentrations by two different assays (fluorescamine, TNBS). A decrease of the detectable free amino groups of 40% was shown by both assays. After the incubation of lysine with dextran these changes could not be observed. These results are explained with the aggregation of LDL particles influenced by dextran.
D003911:Dextrans / Q000494:pharmacology*; D006801:Humans; D008077:Lipoproteins, LDL / Q000737:chemistry / Q000187:drug effects*; D008970:Molecular Weight; D013499:Surface Properties
D003911:Dextrans; D008077:Lipoproteins, LDL
In-vitro-Effekte von niedermolekularem Dextran auf die Oberflächeneigenschaften von LDL.