title: Hypocalcemia after therapeutic use of magnesium sulfate.
abstract: It is now recognized that magnesium plays an important role in calcium homeostasis. Although the effects of hypomagnesemia have been frequently reported, little has been written to suggest a clinically important role for hypermagnesemia. A case is reported in which severe hypocalcemia, with a low plasma parathyroid hormone (PTH) concentration, resulted from the therapeutic use of magnesium sulfate for toxemia of pregnancy. Following recovery, the parathyroid glands were shown to respond normally to a phosphate load. It is suggested that the hypermagnesemia directly suppressed PTH secretion, resulting in symptomatic hypocalcemia.
mesh_terms: D000328:Adult; D002118:Calcium / Q000097:blood / Q000627:therapeutic use; D005260:Female; D006801:Humans; D006996:Hypocalcemia / Q000139:chemically induced* / Q000503:physiopathology; D008278:Magnesium Sulfate / Q000009:adverse effects* / Q000627:therapeutic use; D010280:Parathyroid Glands / Q000503:physiopathology; D010281:Parathyroid Hormone / Q000097:blood; D011188:Potassium / Q000008:administration & dosage; D011225:Pre-Eclampsia / Q000188:drug therapy*; D011247:Pregnancy
chemical_list: D010281:Parathyroid Hormone; D008278:Magnesium Sulfate; D011188:Potassium; D002118:Calcium