[Change in aldosterone secretion by the adrenals and in its urinary excretion in rats under the action of acid polysaccharides].
Repeated administration of chondroitin sulfate to rats in doses of 20 and 120 mg/kg/24 hours led to reduction in the level of urinary aldosterone excretion in rats. Carboxymethylcellulose and alginic acid displayed no inhibitory effect. Urinary aldosterone excretion decreased in rats 24 hours after a single administration of chondroitin sulfate; this effect persisted for the following 3-4 days. The maximal reduction of aldosterone excretion (by 50%) occurred on the 3rd and the 4th day after administration of the preparation. Intraperitoneal injection of chondroitin sulfate to rats diminished the rate of aldosterone secretion by the adrenal glands; as to corticosterone secretion--it remained unchanged.
D000311:Adrenal Glands / Q000187:drug effects* / Q000378:metabolism; D000450:Aldosterone / Q000378:metabolism* / Q000652:urine; D000464:Alginates / Q000494:pharmacology; D000818:Animals; D002266:Carboxymethylcellulose Sodium / Q000494:pharmacology; D002809:Chondroitin Sulfates / Q000494:pharmacology; D003345:Corticosterone / Q000378:metabolism; D006493:Heparin / Q000494:pharmacology; D008297:Male; D011134:Polysaccharides / Q000494:pharmacology*; D051381:Rats; D013997:Time Factors
D000464:Alginates; D011134:Polysaccharides; D000450:Aldosterone; D006493:Heparin; D002809:Chondroitin Sulfates; D002266:Carboxymethylcellulose Sodium; D003345:Corticosterone
Izmenenie sekretsii al'dosterona nadpochechnikami i ékskretsii ego s mochoĭ u krys pri vozdeĭstvii kislykh polisakharidov