Relationship between desaturation and chain elongation of palmityl-CoA in rat liver microsomes.
The relationship between desaturation and chain elongation of palmityl-CoA was studied in rat liver microsomes. Enzyme activities for desaturation and chain elongation were stimulated by re-feeding starved rats. The activities of desaturation and chain elongation in re-fed rats were four- and twofold greater than those in normal rats, respectively. When a sonicated dispersion of lecithin was added to the incubation medium containing both reactions, chain elongation activity, especially formation of stearic acid, was stimulated and desaturation activity was apparently depressed.
D000818:Animals; D003065:Coenzyme A / Q000378:metabolism*; D044943:Fatty Acid Desaturases / Q000378:metabolism*; D005227:Fatty Acids / Q000096:biosynthesis; D005260:Female; D008862:Microsomes, Liver / Q000378:metabolism*; D010169:Palmitic Acids / Q000378:metabolism*; D051381:Rats; D013217:Starvation / Q000378:metabolism
D005227:Fatty Acids; D010169:Palmitic Acids; D044943:Fatty Acid Desaturases; D003065:Coenzyme A