title: Produced by selective breeding of Japanese quail animal model for experimental atherosclerosis.
abstract: The Japanese quail (Coturnix coturnix japonica) was bred selectively to produce a strain highly susceptible to experimental atherosclerosis. A population was produced where aortic atherosclerosis is contracted by 99% of the fourth generation males and 83% of the femlaes. Forty-three percent of the males exhibited severe atherosclerosis making this line of Japanese quail a suitable model for discovering and testing anti-atherosclerosis compounds. This feature is augmented by other features such as size, disposition, and abundance which qualify them as suitable experimental subjects. A second line of Japanese quail was bred to be resistant to dietary-induced atherosclerosis. This strain may be a useful research tool for characterizing the etiology of atherosclerosis.
mesh_terms: D000469:Alkaline Phosphatase / Q000097:blood; D000818:Animals; D001011:Aorta / Q000473:pathology; D001161:Arteriosclerosis / Q000209:etiology* / Q000473:pathology; D001947:Breeding; D002784:Cholesterol / Q000032:analysis / Q000097:blood; D002791:Cholesterol, Dietary / Q000009:adverse effects; D003370:Coturnix / Q000033:anatomy & histology* / Q000097:blood; D004036:Diet, Atherogenic / Q000009:adverse effects; D004195:Disease Models, Animal; D005260:Female; D008297:Male; D011784:Quail / Q000033:anatomy & histology*
chemical_list: D002791:Cholesterol, Dietary; D002784:Cholesterol; D000469:Alkaline Phosphatase