title: Uptake of bovine serum albumin by rainbow trout from hypersmotic solutions: a model for vaccinating fish.
abstract: Immersion of juvenile rainbow trout (Salmo gairdneri) in a solution containing either urea or sodium chloride at 1650 milliosmoles and 2 percent of bovine serum albumin (BSA) resulted in an uptake of BSA into the blood of the fish after a 3-minute exposure. Similar blood levels of BSA were also obtained by placing the fish in 1650 millosmoles of sodium chloride for about 2 minutes, and then immersing them in 2 percent BSA solution for 3 minutes. Uptake of BSA into the fish appeared to be primarily through the lateral line system and secondarily through the gills.
mesh_terms: D000818:Animals; D001692:Biological Transport / Q000187:drug effects; D005393:Fish Diseases / Q000517:prevention & control*; D005880:Gills / Q000378:metabolism; D007114:Immunization / Q000662:veterinary*; D008208:Lymphatic System / Q000378:metabolism; D012462:Saline Solution, Hypertonic / Q000494:pharmacology; D012487:Salmonidae / Q000378:metabolism*; D012710:Serum Albumin, Bovine / Q000276:immunology / Q000378:metabolism*; D012965:Sodium Chloride / Q000494:pharmacology; D014337:Trout / Q000097:blood / Q000276:immunology / Q000378:metabolism*; D014508:Urea / Q000494:pharmacology
chemical_list: D012462:Saline Solution, Hypertonic; D012710:Serum Albumin, Bovine; D012965:Sodium Chloride; D014508:Urea