Melatonin antagonizes colchicine-induced mitotic arrest.
Melatonin, in concentrations up to 10(-3) M, showed no effect on mitosis in cultures of HeLa or KB cells. However, when melatonin at 10(-4) M was preincubated with HeLa cells prior to addition of 10(-7) M colchicine, a reduction in the mitotic index, in comparison to colchicine alone, was observed.
D000818:Animals; D002460:Cell Line; D003078:Colchicine / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D006367:HeLa Cells / Q000187:drug effects*; D066298:In Vitro Techniques; D008550:Melatonin / Q000494:pharmacology*; D008938:Mitosis / Q000187:drug effects*
D008550:Melatonin; D003078:Colchicine