[Effect of kontrikal on the course of experimental nonspecific phacogenic uveitis].
Nonspecific phacogenic uveitis (NPGU) was simulated in 21 chinchilla rabbits to follow the time course of the blood serum proteolytic activity and the principal protease inhibitors (alpha 1 inhibitor and alpha 2 macroglobulin) in various stages of the inflammatory process. Effects of contrykal, a synthetic protease inhibitor, on these parameters and the course of the inflammation was also under study. The results evidence that i.v. and subconjunctival contrykal administration reduced the periods of NPGU treatment 1.5-2 times.
D000818:Animals; D007611:Aprotinin / Q000627:therapeutic use*; D065306:Corneal Injuries; D004195:Disease Models, Animal; D004789:Enzyme Activation / Q000187:drug effects / Q000502:physiology; D015807:Eye Injuries, Penetrating / Q000150:complications* / Q000201:enzymology; D007908:Lens, Crystalline / Q000201:enzymology; D011480:Protease Inhibitors / Q000627:therapeutic use*; D011817:Rabbits; D014605:Uveitis / Q000188:drug therapy* / Q000201:enzymology / Q000209:etiology; D000515:alpha 1-Antitrypsin / Q000378:metabolism
D011480:Protease Inhibitors; D000515:alpha 1-Antitrypsin; D007611:Aprotinin
Vliianie kontrikala na techenie nespetsificheskogo fakogennogo uveita v éksperimente.