title: Effects of pentazocine on coronary hemodynamics under pentobarbital or chloralose-urethane anesthesia in dogs.
abstract: The effect of pentazocine on the coronary hemodynamics was studied in anesthetized dogs. Under pentobarbital anesthesia pentazocine did not cause any significant changes in the coronary hemodynamics. Under chloralose-urethane anesthesia, however, it produced a statistically significant increase in heart rate, left coronary blood flow rate, myocardial oxygen consumption as well as myocardial oxygen extraction rate, but a decrease in coronary vascular resistance. These results indicate that the effects of pentazocine on the coronary hemodynamics are modified significantly by the drugs used for basal anesthesia.
mesh_terms: D000771:Anesthesia, Intravenous; D000818:Animals; D001783:Blood Flow Velocity; D001794:Blood Pressure / Q000187:drug effects; D002698:Chloralose / Q000494:pharmacology*; D003326:Coronary Circulation / Q000187:drug effects*; D004285:Dogs; D006339:Heart Rate / Q000187:drug effects; D006439:Hemodynamics / Q000187:drug effects*; D010101:Oxygen Consumption / Q000187:drug effects; D010423:Pentazocine / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D010424:Pentobarbital / Q000494:pharmacology*; D014520:Urethane / Q000494:pharmacology*; D014655:Vascular Resistance / Q000187:drug effects
chemical_list: D002698:Chloralose; D014520:Urethane; D010424:Pentobarbital; D010423:Pentazocine