Concerning the ionic basis of presynaptic inhibition.
The superfused rat cuneate nucleus has been used to investigate the sensitivity of primary afferent terminals and of evoked primary afferent depolarization (PAD) to alterations in extracellular K+ and Cl- ions levels. Results indicate that PAD is caused by an efflux of Cl- from primary afferent terminals rather than by an increase in extracellular K+.
D000818:Animals; D002712:Chlorides / Q000494:pharmacology*; D003214:Conditioning, Classical; D004558:Electric Stimulation; D008475:Median Nerve / Q000502:physiology; D008526:Medulla Oblongata / Q000187:drug effects / Q000502:physiology*; D009475:Neurons, Afferent / Q000187:drug effects / Q000502:physiology; D010477:Perfusion; D011188:Potassium / Q000494:pharmacology*; D051381:Rats; D013569:Synapses / Q000187:drug effects / Q000502:physiology
D002712:Chlorides; D011188:Potassium