Tin: a potent inducer of heme oxygenase in kidney.
Tin greatly enhances heme breakdown in kidney, thus impairing heme-dependent cellular functions, such as cytochrome P-450 mediated drug biotransformation. This novel action of the metal results from a potent induction effect on heme oxygenase, the enzyme that catalyzes heme oxidation in microsomes. The possible toxicological implications of this tin effect in the kidney merit further investigation.
D000624:5-Aminolevulinate Synthetase / Q000096:biosynthesis; D000818:Animals; D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism; D004790:Enzyme Induction / Q000187:drug effects; D006418:Heme / Q000378:metabolism*; D007668:Kidney / Q000187:drug effects* / Q000201:enzymology / Q000648:ultrastructure; D008297:Male; D008861:Microsomes / Q000201:enzymology; D008862:Microsomes, Liver / Q000201:enzymology; D006899:Mixed Function Oxygenases / Q000096:biosynthesis*; D051381:Rats; D014001:Tin / Q000494:pharmacology* / Q000633:toxicity
D006418:Heme; D014001:Tin; D003577:Cytochrome P-450 Enzyme System; D006899:Mixed Function Oxygenases; D000624:5-Aminolevulinate Synthetase