title: Regeneration of an adult peripheral nerve preparation in culture.
abstract: The methods used to maintain the vagus nerve from the adult rat in culture and how regeneration is studied in this preparation are described. A hypothesis is presented on the triggering of the cell body reaction. It is suggested that this reaction is initiated by proteins synthesized in nonneuronal cells at the site of a nerve lesion. These proteins, referred to as regenerins, reach the nerve cell body by retrograde axonal transport, where they initiate the regeneration process.
mesh_terms: D000818:Animals; D001370:Axonal Transport; D002470:Cell Survival; D005260:Female; D009409:Nerve Crush; D009416:Nerve Regeneration / Q000502:physiology*; D009620:Nodose Ganglion / Q000502:physiology; D009924:Organ Culture Techniques / Q000295:instrumentation / Q000379:methods; D051381:Rats; D017207:Rats, Sprague-Dawley; D014630:Vagus Nerve / Q000166:cytology / Q000502:physiology*