[The effect of oxyphenbutazone and flufenamic acid in vitro on the purine salvage pathway of human lymphocytes (author's transl)].
The effect of oxyphenbutazone and flufenamic acid was investigated on the enzymes of the purine salvage pathway of human lymphocytes in vitro. A distinct decrease in adenine-phosphoribosyltransferase activity and in guanine-hypoxanthine-phosphoribosyltransferase activity was observed following the administration of either pharmacological preparation. The loss of enzyme activity was 23 to 39%. The pharmaceuticals were used at a concentration of 50 mug%.
D000228:Adenine Phosphoribosyltransferase / Q000097:blood; D004791:Enzyme Inhibitors; D005439:Flufenamic Acid / Q000494:pharmacology*; D007041:Hypoxanthine Phosphoribosyltransferase / Q000097:blood; D008214:Lymphocytes / Q000187:drug effects* / Q000201:enzymology; D010113:Oxyphenbutazone / Q000494:pharmacology*; D011687:Purines / Q000378:metabolism*
D004791:Enzyme Inhibitors; D011687:Purines; D005439:Flufenamic Acid; D000228:Adenine Phosphoribosyltransferase; D007041:Hypoxanthine Phosphoribosyltransferase; D010113:Oxyphenbutazone
Einfluss von Oxyphenbutazon und Flufenaminsäure in vitro auf den Purin-Wiederverwertungsstoffwechsel menschlicher Lymphozyten