An ultrastructural evaluation of the effect of hydrocortisone on rabbit cartilage.
Pharmacologic and supra-pharmacologic doses of hydrocortisone acetate did not effect ultrastructural alteration of chondrocytes in articular cartilage of mature rabbits. Early biomechanical alterations are unaccompanied by ultrastructural cytological changes. Not until advanced biochemical alteration is effected by large, repetitive doses, does the ultrastructural alteration begin.
D000818:Animals; D002358:Cartilage, Articular / Q000187:drug effects / Q000648:ultrastructure*; D005260:Female; D006854:Hydrocortisone / Q000008:administration & dosage / Q000494:pharmacology*; D008297:Male; D011817:Rabbits
D006854:Hydrocortisone