title: Precursor lesions of bronchogenic carcinoma.
abstract: Clinical investigations and experimental studies concerned with preneoplastic and early neoplastic lesions in the respiratory tract are discussed. The occurrence of preinvasive states of carcinoma in the bronchus has been recognized for over 20 years. Histopathological and cytological studies suggest that it might become possible to identify even earlier preneoplastic precursor lesions provided the proper tissue or cell markers can be found. Experimental models that could be useful in establishing a better understanding of the evolution of the neoplastic diseases in the respiratory tract are now available.
mesh_terms: D000368:Aged; D000818:Animals; D002273:Carcinogens / Q000008:administration & dosage; D003937:Diagnosis, Differential; D004195:Disease Models, Animal; D006801:Humans; D008175:Lung Neoplasms / Q000175:diagnosis*; D008875:Middle Aged; D009374:Neoplasms, Experimental; D011230:Precancerous Conditions / Q000175:diagnosis*; D014134:Tracheal Neoplasms / Q000139:chemically induced
chemical_list: D002273:Carcinogens