Role of early afterdepolarization in familial long QTU syndrome and torsade de pointes.
Torsade de pointes (TdP) syncopal episodes were almost invariably precipitated by emotional stress or menstruation in a 17-year-old girl. U wave accentuation occurred during sinus rhythm without pauses in periods of heightened sympathetic tone. To examine the role of early afterdepolarization (EAD), monophasic action potentials were recorded during ventricular extrasystoles and TdP occurring spontaneously and induced by ventricular pacing. The effects of lidocaine, verapamil, propranolol, and epinephrine were assessed. Our data show that: (1) EAD plays a significant role in the genesis of familial long QTU syndrome and TdP; (2) rapid ventricular pacing causes postpause-dependent EADs, U waves, and TdP; and (3) EAD is enhanced by epinephrine infusion in the absence of pause, whereas EAD-triggered firing is inhibited by verapamil and propranolol but not by lidocaine.
D000200:Action Potentials / Q000502:physiology; D000293:Adolescent; D002304:Cardiac Pacing, Artificial; D004837:Epinephrine / Q000494:pharmacology; D005260:Female; D006329:Heart Conduction System / Q000503:physiopathology*; D006801:Humans; D008012:Lidocaine / Q000494:pharmacology; D008133:Long QT Syndrome / Q000175:diagnosis / Q000235:genetics* / Q000503:physiopathology*; D008598:Menstruation; D011433:Propranolol / Q000494:pharmacology; D013315:Stress, Psychological / Q000150:complications; D013575:Syncope / Q000209:etiology; D016171:Torsades de Pointes / Q000503:physiopathology*; D014700:Verapamil / Q000494:pharmacology
D008012:Lidocaine; D011433:Propranolol; D014700:Verapamil; D004837:Epinephrine