title: Synthesis of histamine analogs.
abstract: Nineteen histamine analogs were synthesized, and their biological actions were compared to those of histamine in blood pressure, gastric secretion, and nasal decongestant screens. The analogs include N-substituted 4-aminoethylimidazoles, N-substituted 2-pyridylethylamines, 2-pyridylcyclohexylamines, and 2-pyridylcyclopropylcarbamates. None of the compounds showed appreciable histamine agonist or antagonist properties.
mesh_terms: D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D004285:Dogs; D005260:Female; D006632:Histamine / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000494:pharmacology; D008297:Male; D008722:Methods; D009297:Nasal Mucosa / Q000187:drug effects / Q000378:metabolism; D051381:Rats
chemical_list: D006632:Histamine