Effects of ouabain and norepinephrine on the mechanical performance of the normal and failing heart of the myopathic hamster.
The effects of ouabain and norepinephrine on the mechanical efficiency of the normal and failing heart of the myopathic Syrian hamster were studied in a modified Langendorff preparation. Ouabain administration to the normal and failing heart caused a significant increase in heart work and energy utilization per beat with no significant change in the mechanical efficinecy of either heart. Norepinephrine caused a significant increase in heart work, energy utilization, and mechanical efficiency of the normal and failing heart. It was concluded that the isolated perfused hamster heart from normal and myopathic hamsters could provide a new model for the demonstration of the effect of cardiotonic agents on the mechanical performance of the heart.
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D006224:Cricetinae; D004195:Disease Models, Animal; D006321:Heart / Q000503:physiopathology; D006333:Heart Failure / Q000473:pathology / Q000503:physiopathology*; D008297:Male; D009206:Myocardium / Q000473:pathology; D009638:Norepinephrine / Q000494:pharmacology*; D010042:Ouabain / Q000494:pharmacology*; D010101:Oxygen Consumption / Q000187:drug effects
D010042:Ouabain; D009638:Norepinephrine