Airway epithelial cells enhance eosinophil survival.
Guinea pig and human eosinophils were co-cultured with or without epithelial cells (controls). Eosinophil survival was enhanced in the presence of the cultured epithelial cells in a number-dependent fashion. Further, supernatants from cultured epithelial cells also enhanced eosinophil survival. Both a monoclonal antibody to GM-CSF and indomethacin inhibited these epithelial-cell-mediated effects, and GM-CSF and PGE2 were shown to prolong eosinophil survival. These findings indicate that airway epithelial cells can enhance eosinophil survival. It is suggested that the mechanism may involve GM-CSF and PGE2 generation.
D000818:Animals; D001249:Asthma / Q000276:immunology / Q000378:metabolism; D002452:Cell Count; D002470:Cell Survival; D002478:Cells, Cultured; D004804:Eosinophils / Q000166:cytology* / Q000502:physiology; D004847:Epithelial Cells; D016179:Granulocyte Colony-Stimulating Factor / Q000096:biosynthesis; D006168:Guinea Pigs; D006801:Humans; D008297:Male; D014132:Trachea / Q000166:cytology* / Q000378:metabolism
D016179:Granulocyte Colony-Stimulating Factor