Myopathy associated with monoclonal gammopathy and leukoencephalopathy.
We report here two patients presenting a myopathy associated with a monoclonal gammopathy (of IgG lambda or IgA kappa type) and, in one case, also with a leukoencephalopathy. Possible etiopathological mechanisms between these neurological diseases and an immune disregulation are discussed.
D001706:Biopsy; D006801:Humans; D007070:Immunoglobulin A / Q000032:analysis; D007074:Immunoglobulin G / Q000032:analysis; D007145:Immunoglobulin kappa-Chains / Q000032:analysis; D007146:Immunoglobulin lambda-Chains / Q000032:analysis; D007968:Leukoencephalopathy, Progressive Multifocal / Q000175:diagnosis* / Q000276:immunology / Q000473:pathology; D008297:Male; D008875:Middle Aged; D008998:Monoclonal Gammopathy of Undetermined Significance / Q000175:diagnosis* / Q000276:immunology / Q000473:pathology; D009132:Muscles / Q000473:pathology; D009135:Muscular Diseases / Q000175:diagnosis* / Q000276:immunology / Q000473:pathology; D009460:Neurologic Examination / Q000187:drug effects
D007070:Immunoglobulin A; D007074:Immunoglobulin G; D007145:Immunoglobulin kappa-Chains; D007146:Immunoglobulin lambda-Chains