Coagulation and fibrinolysis in pregnancies complicated by fetal growth retardation.
Saline extracts were made from portions of 17 normal placentae and from 8 placentae from pregnancies complicated by fetal growth retardation, but not hypertension. The ability of these extracts to inhibit urokinase-induced fibrinolysis was measured using a fibrin plate technique. Placental extracts from pregnancies complicated by fetal growth retardation exhibited greater inhibition of urokinase-induced fibrinolysis. There was no evidence of disseminated intravascular coagulation in these patients, but certain coagulation factors in the peripheral blood were raised.
D001724:Birth Weight; D001777:Blood Coagulation; D005260:Female; D005333:Fetus / Q000502:physiology; D005342:Fibrinolysis; D005865:Gestational Age; D006128:Growth; D006801:Humans; D009929:Organ Size; D010920:Placenta / Q000378:metabolism; D010922:Placenta Diseases / Q000097:blood*; D011247:Pregnancy; D011250:Pregnancy Complications, Hematologic / Q000097:blood; D014020:Tissue Extracts / Q000494:pharmacology; D014568:Urokinase-Type Plasminogen Activator / Q000037:antagonists & inhibitors
D014020:Tissue Extracts; D014568:Urokinase-Type Plasminogen Activator