title: Effect of estradiol-17beta on blood flow to reproductive and nonreproductive tissues in pregnant ewes.
abstract: The effect of estradiol-17beta (1 mug per kilogram) on regional blood flow and cardiac output was studied by means of radionuclide-labeled microspheres in 6 nonpregnant and 13 pregnant ewes five to seven days after operation. Estradiol caused vasodilation in myometrium, endometrium, and placental cotyledons throughout pregnancy, but these responses were significantly less than the fifteenfold increase seen in the nonpregnant uterine tissues. Significant vasodilation also occurred in the ovaries, cervix, vagina, uterine tubes, mammary gland, skin, and adrenal glands of pregnant ewes. Cardiac output increased by 14%. No significant change in uterine oxygen consumption was associated with the increase in blood flow to the pregnant uterus.
mesh_terms: D000311:Adrenal Glands / Q000098:blood supply; D000818:Animals; D002302:Cardiac Output / Q000187:drug effects; D003326:Coronary Circulation / Q000187:drug effects; D004958:Estradiol / Q000494:pharmacology*; D005260:Female; D008102:Liver Circulation / Q000187:drug effects; D008321:Mammary Glands, Animal / Q000098:blood supply; D009132:Muscles / Q000098:blood supply; D010053:Ovary / Q000098:blood supply; D010101:Oxygen Consumption / Q000187:drug effects; D011247:Pregnancy; D012039:Regional Blood Flow / Q000187:drug effects; D012756:Sheep; D012867:Skin / Q000098:blood supply; D014599:Uterus / Q000098:blood supply*; D014621:Vagina / Q000098:blood supply
chemical_list: D004958:Estradiol