Effects of 5-vinyloxazolidine-2-thione on lactating rats and their sucklings.
5-vinyloxazolidine-2-thione (VOT) administered orally to lactating rats was found to be efficiently transferred to the sucklings via the milk. In mothers the exposure to VOT resulted in an increased percentage of neutrophils, a decreased percentage of lymphocytes and increases in the relative weights of liver and thyroid. Suckling rats showed a decreased number of leucocytes, increases in the relative weights of liver and thyroid and structural changes in the thyroid. Male sucklings were more affected than female pups. The antithyroid effects were clearly related to the maternally administered VOT doses.
D000818:Animals; D000833:Animals, Suckling / Q000502:physiology*; D013956:Antithyroid Agents / Q000633:toxicity*; D001835:Body Weight / Q000187:drug effects; D005260:Female; D007774:Lactation / Q000187:drug effects*; D007958:Leukocyte Count / Q000187:drug effects; D008297:Male; D009929:Organ Size / Q000187:drug effects; D010080:Oxazoles / Q000633:toxicity*; D023303:Oxazolidinones; D051381:Rats; D017208:Rats, Wistar; D013961:Thyroid Gland / Q000187:drug effects
D013956:Antithyroid Agents; D010080:Oxazoles; D023303:Oxazolidinones; C004333:goitrin