title: Intragastric NaHCO3 perfusion and vagal-induced ulcer formation in the rat stomach.
abstract: The effects of electrical vagal stimulation on gastric acid output and ulcer formation were studied in rats intragastrically perfused with saline or NaHCO3 solutions. Vagal stimulation produced a 100% incidence of glandular lesions and a significant increase in total acid output in saline-perfused stomachs. Antacid perfusion failed to prevent ulcer formation despite complete neutralization of the increased acid output. It is considered that vagal-induced gastric glandular lesions are not acid dependent.
mesh_terms: D000818:Animals; D001639:Bicarbonates / Q000494:pharmacology*; D004558:Electric Stimulation; D005750:Gastric Juice / Q000378:metabolism*; D008297:Male; D051381:Rats; D013276:Stomach Ulcer / Q000209:etiology*; D014630:Vagus Nerve / Q000502:physiology*
chemical_list: D001639:Bicarbonates