Acute toxicity of dimethylnitrosamine in the presence of inhibitors of DMN demethylase.
The LD50 of DMN was determined in groups of mice in the presence of inhibitors of DMN demethylase. Piperonyl butoxide, dibutylnitrosamine and nitrososarcosine had no effect on the acute toxicity of DMN. Diethylnitrosamine and DMN were markedly synergistic. All mice treated with 100 mg/kg diethylnitrosamine and 10.7 mg/kg DMN died. These results suggest that DMN demethylase may not be involved in the acute toxicity of DMN.
D000818:Animals; D003201:Computers; D004052:Diethylnitrosamine / Q000494:pharmacology; D004128:Dimethylnitrosamine / Q000378:metabolism / Q000633:toxicity*; D004357:Drug Synergism; D007928:Lethal Dose 50; D008297:Male; D051379:Mice; D009602:Nitrosamines / Q000633:toxicity*; D010089:Oxidoreductases, N-Demethylating / Q000037:antagonists & inhibitors*
D009602:Nitrosamines; D004052:Diethylnitrosamine; D010089:Oxidoreductases, N-Demethylating; D004128:Dimethylnitrosamine