Antiinflammatory activity of two phenylindandione derivatives.
2-5-Dibromo-2-(beta-naphtyl)indan-1,3-dione (43/63) and 4-bromo-2-phenylindan-1,3-dione (43/13) are two interesting members of a series of "indandione" derivatives which possess an antiinflammatory activity (in the following tests: carrageenin induced rat hind paw edema, cotton pellets granuloma and chronic adjuvant arthritis). The two drugs are devoided of anticoagulant activity and their antiinflammatory effect is not adrenalmediated.
D000818:Animals; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use* / Q000633:toxicity; D001172:Arthritis, Rheumatoid / Q000188:drug therapy; D001799:Blood Sedimentation; D004487:Edema / Q000188:drug therapy; D007928:Lethal Dose 50; D008297:Male; D051379:Mice; D009281:Naphthalenes / Q000494:pharmacology; D010630:Phenindione / Q000031:analogs & derivatives* / Q000494:pharmacology; D051381:Rats
D000893:Anti-Inflammatory Agents; D009281:Naphthalenes; D010630:Phenindione