Efficacy of divided doses of fospirate against immature Echinococcus granulosus infections in dogs.
Seventy dogs were used to evaluate efficacy of divided doses of fospirate against immature Echinococcus granulosus infections in dogs. Dose rates of 10 to 80 mg/kg given on 1 or 2 occasions resulted in the clearance of 70.6 to 94.5% of expected worm numbers. At least 3 treatments may be required before dogs can be free from E granulosus. Vomiting, which occurred in dogs given doses of 40 mg or more/kg, seemed to interfere with anthelmintic efficacy in some dogs.
D000818:Animals; D000871:Anthelmintics / Q000008:administration & dosage* / Q000009:adverse effects / Q000627:therapeutic use; D004283:Dog Diseases / Q000188:drug therapy*; D004285:Dogs; D004443:Echinococcosis / Q000188:drug therapy / Q000662:veterinary*; D009943:Organophosphorus Compounds / Q000008:administration & dosage*; D011725:Pyridines / Q000008:administration & dosage*
D000871:Anthelmintics; D009943:Organophosphorus Compounds; D011725:Pyridines; C010964:fospirate