[Adrenergic reactivity of the gastro-intestinal tract. II. Colon of the guinea pig and cecum of the mice].
A study has been made of the alpha- and beta-adrenoreceptors in the guinea pig colon and the mouse caecum using noradrenalina as agonist and alpha- and beta-adrenolytics separately or together. In the guinea pig colon alpha-adrenolytics used alone did not alter the action of noradrenalin: one beta-lytic (propranolol) used alone has slight non dose-dependent action. The alpha-lytics used together with beta-lytic strongly potential their effect. These results are interpreted as indicating that the preparation contains alpha-receptors as well as beta-receptors; activation of the alpha-receptors is observed only when the beta-mimetic effect of noradrenalin is inhibited. In the mouse caecum alpha-lytics prove devoid of effect either alone or when associated with beta-lytics; it is deduced therefore that this preparation contains only beta-receptors.
D000818:Animals; D002432:Cecum / Q000187:drug effects*; D003106:Colon / Q000187:drug effects*; D003983:Dibenzylchlorethamine / Q000494:pharmacology*; D006168:Guinea Pigs; D008297:Male; D051379:Mice; D009638:Norepinephrine / Q000037:antagonists & inhibitors; D011433:Propranolol / Q000494:pharmacology*; D011941:Receptors, Adrenergic / Q000187:drug effects*
D011941:Receptors, Adrenergic; D003983:Dibenzylchlorethamine; D011433:Propranolol; D009638:Norepinephrine
Reattività adrenergica nel tratto gastro-enterico. Nota II - Colon di cavia e cieco di topolino