title: Studies in dogs and cats dosed with trimethoprim and sulphadiazine.
abstract: Serum level studies in cats and dogs dosed with 30 mg per kg per day of either oral or injectable formulations of a 1:5 trimethoprim/sulphadiazine combination showed good absorption by both routes of administration. Toxicity tests with the products demonstrated a high margin of safety in dogs given this dose level; the margin of safety in cats was lower but still adequate. The high success rate in clinical trials against a wide range of bacterial infections confirmed the predictions from the serum level results that a dose rate of 30 mg per kg per day orally or parentally, would be therapeutically efficacious in both species.
mesh_terms: D000818:Animals; D001424:Bacterial Infections / Q000188:drug therapy / Q000662:veterinary; D002371:Cat Diseases / Q000188:drug therapy*; D002415:Cats; D004285:Dogs; D004906:Erythrocyte Count; D006400:Hematocrit; D013411:Sulfadiazine / Q000097:blood / Q000627:therapeutic use / Q000633:toxicity*; D014295:Trimethoprim / Q000097:blood / Q000627:therapeutic use / Q000633:toxicity*
chemical_list: D013411:Sulfadiazine; D014295:Trimethoprim