[The influence of glucagon on post-heparin plasma lipolytic activity in normal rats and in rats with diabetes induced by alloxan injection].
The authors compared the effect of glucagon on the post-heparinic lipolytic activity in normal and alloxan induced diabetic rats. Within their experimental conditions, it was considered that an injury of the cell stimulates a decrease of the glucagon-stimulating activity on the lipoprotein lipase: this hormone does not seem to have a direct action on the PHLA but an indirect one by the way of the insulin secretion it induces.
D000818:Animals; D003921:Diabetes Mellitus, Experimental / Q000503:physiopathology*; D005230:Fatty Acids, Nonesterified / Q000097:blood; D005934:Glucagon / Q000008:administration & dosage / Q000494:pharmacology*; D006493:Heparin / Q000008:administration & dosage / Q000494:pharmacology; D007328:Insulin / Q000378:metabolism; D000078790:Insulin Secretion; D008071:Lipoprotein Lipase / Q000037:antagonists & inhibitors / Q000097:blood / Q000378:metabolism*; D008297:Male; D051381:Rats; D013268:Stimulation, Chemical; D013997:Time Factors
D005230:Fatty Acids, Nonesterified; D007328:Insulin; D006493:Heparin; D005934:Glucagon; D008071:Lipoprotein Lipase
Influence du glucagon sur l'activité lipolytique post-héparinque du plasma chez le rat normal et chez le rat rendu diabétique par injection d'alloxane