title: Excretion, distribution and metabolic fate of 3H-alpha-chaconine.
abstract: 3H-alpha-Chaconine was poorly absorbed from the gastrointestinal tract and rapidly excreted in feces when administered orally to male rats. Intraperitoneal administration of low doses (5 to 10 mg/kg) resulted in urinary and fecal excretion of metabolites, and probably involved biliary excretion. High, toxic, intraperitoneal doses (15 to 25 mg/kg) depressed fecal and urinary elimination, and resulted in accumulation of tritium in various tissues. The major metabolite appeared to be the aglycone, solanidine. Alpha-chaconine is very similar to alpha-solanine in its elimination  by and distribution in tissues of rats.
mesh_terms: D000284:Administration, Oral; D000470:Alkaloids / Q000008:administration & dosage / Q000378:metabolism*; D000818:Animals; D005243:Feces / Q000032:analysis; D007408:Intestinal Absorption; D008297:Male; D051381:Rats; D013997:Time Factors
chemical_list: D000470:Alkaloids