The core protein of epican, a heparan sulfate proteoglycan on keratinocytes, is an alternative form of CD44.
Epican, a heparan sulfate proteoglycan, was recently identified on the surface of keratinocytes with the aid of a monoclonal antibody to its core protein. Using that antibody to screen a human keratinocyte cDNA library, a clone encoding the entire epican core protein was selected and sequenced. The core protein of epican is a form of CD44. The deduced protein sequence of 699 amino acids has a novel 339 amino acid domain inserted into the proximal extracellular domain of the standard, leukocyte form of CD44. The additional domain adds a number of potential N- and O-linked glycosylation sites and two proteolysis sites to this form of CD44.
D000595:Amino Acid Sequence / Q000235:genetics; D000911:Antibodies, Monoclonal; D001482:Base Composition / Q000235:genetics; D001483:Base Sequence / Q000235:genetics; D002999:Clone Cells / Q000737:chemistry; D006497:Heparan Sulfate / Q000737:chemistry; D006801:Humans; D018960:Hyaluronan Receptors; D015603:Keratinocytes / Q000737:chemistry* / Q000276:immunology; D008297:Male; D008969:Molecular Sequence Data; D009693:Nucleic Acid Hybridization; D016366:Open Reading Frames; D011509:Proteoglycans / Q000737:chemistry*; D012313:RNA / Q000235:genetics; D016201:Receptors, Lymphocyte Homing / Q000737:chemistry*
D000911:Antibodies, Monoclonal; D006497:Heparan Sulfate; D018960:Hyaluronan Receptors; D011509:Proteoglycans; D012313:RNA; D016201:Receptors, Lymphocyte Homing; C077089:CD44, keratinocyte