Ultrasonic enhancement of nitrogen mustard cytotoxicity in mouse leukemia.
Mouse leukemia L1210 cells were exposed to continuous wave 2 MHz, 10 W/cm(2) ultrasound for 10 minutes while suspended in nitrogen mustard solution in vitro. Mice subsequently inoculated with these cells had longer survival times than control animals that received cells exposed to the drug but not ultrasound. Without the drug, ultrasound did not alter survival time. Tracer studies revealed increased cellular accumulation of drug under the influence of ultrasound.
D000818:Animals; D002470:Cell Survival / Q000187:drug effects; D002478:Cells, Cultured; D007939:Leukemia L1210 / Q000188:drug therapy*; D008466:Mechlorethamine / Q000627:therapeutic use*; D051379:Mice; D008811:Mice, Inbred DBA; D009368:Neoplasm Transplantation; D014184:Transplantation, Homologous; D014465:Ultrasonics
D008466:Mechlorethamine