Pyrithiamine-induced thiamine deficiency: effects on rat myelination.
Pyrithiamine was administered to newborn rats throughout the vulnerable period for myelinogenesis. A major metabolic defect was produced in the cerebral activities of the thiamine-dependent enzymes, transketolase and pyruvate decarboxylase. In spite of a defect in carbohydrate metabolism which is lethal in adult rats, overall development, and myelination as indicated by biochemical and morphological criteria, proceeded at an essentially normal rate. These findings indicate alternative metabolic pathways may be operational in newborn rat brain enabling it to circumvent major blockage in thiamine-dependent reactions.
D000818:Animals; D000831:Animals, Newborn / Q000378:metabolism; D001921:Brain / Q000187:drug effects / Q000201:enzymology / Q000378:metabolism*; D002554:Cerebrosides / Q000378:metabolism; D002784:Cholesterol / Q000378:metabolism; D004305:Dose-Response Relationship, Drug; D009186:Myelin Sheath / Q000378:metabolism*; D009419:Nerve Tissue Proteins / Q000378:metabolism; D010743:Phospholipids / Q000378:metabolism; D011743:Pyrimidines / Q000494:pharmacology*; D011767:Pyruvate Decarboxylase / Q000378:metabolism; D011773:Pyruvates / Q000378:metabolism; D051381:Rats; D013832:Thiamine Deficiency / Q000139:chemically induced*; D014174:Transketolase / Q000378:metabolism
D002554:Cerebrosides; D009419:Nerve Tissue Proteins; D010743:Phospholipids; D011743:Pyrimidines; D011773:Pyruvates; D002784:Cholesterol; D014174:Transketolase; D011767:Pyruvate Decarboxylase