Role of stimulus locale on strain differences in active avoidance after scopolamine of D-amphetamine treatment.
Three strains of mice were trained in a shuttle avoidance task following treatment with scopolamine (2.0 mg/kg) or d-amphetamine (3.0 mg/kg). When required to run towards light (CS) to avoid shock, A/J mice acquired the response more readily than DBA/2J or C57BL/6J mice. However, when required to run away from the light, the strain differences were eliminated. Under both testing conditions scopolamine and d-amphetamine augmented the performance of A/J mice, but had no effect of even disrupted performance of C57BL/6J. In DBA/2J mice d-amphetamine augmented performance only in the toward condition. Results were interpreted to support the hypothesis that scopolamine and d-amphetamine improve performance by response-disinhibition and response excitation, respectively. The presence of associative difficulties limit the effects of these agents.
D000818:Animals; D001362:Avoidance Learning / Q000187:drug effects*; D003913:Dextroamphetamine / Q000494:pharmacology*; D005260:Female; D008297:Male; D051379:Mice; D008805:Mice, Inbred A; D008810:Mice, Inbred C57BL; D008811:Mice, Inbred DBA; D010775:Photic Stimulation; D012601:Scopolamine / Q000494:pharmacology*; D013045:Species Specificity
D012601:Scopolamine; D003913:Dextroamphetamine