Effects of aspirin on gastric prostaglandin E (PGE) and acid output in normal subjects.
Aspirin administration to normal subjects resulted in a reduction in gastric prostaglandin E (PGE) output. Both PGE concentration and gastric juice volume were decreased. Gastric acid output also decreased, although the difference was not statistically significant. An increased sensitivity of the PGE system to inhibition by aspirin at 11 p.m., midnight, and 1am was observed.
D000328:Adult; D001241:Aspirin / Q000097:blood / Q000494:pharmacology*; D002940:Circadian Rhythm / Q000187:drug effects; D005745:Gastric Acidity Determination; D005750:Gastric Juice / Q000032:analysis / Q000378:metabolism*; D006801:Humans; D008297:Male; D011458:Prostaglandins E / Q000032:analysis / Q000378:metabolism*; D013270:Stomach / Q000187:drug effects
D011458:Prostaglandins E; D001241:Aspirin