The dosimetry of radioisotopes incorporated in bone using cavity ionization theory.
Cavity ionization theory is applied to the dosimetry of bones incorporating beta- and gamma-emitting radioactive isotopes. The assumptions inherent in different theoretical approaches to bone dosimetry are reviewed and compared with those adopted in cavity theory. In presenting the theory attention is given to the effects of electron and photon attenuation and to the absence of electronic equilibrium which may occur in bone. The mean marrow dose is calculated for a range of cavity size and gamma-ray energies and for a beta-ray emitter. The mean marrow dose and the mean endosteal dose are calculated for a human lumbar vertebra and some comparisons made with the results of other workers. It is concluded that cavity theory provides a useful approach to the dosimetry problems of bone-seeking beta- and gamma-ray radioactive isotopes.
D000328:Adult; D001608:Beryllium; D001842:Bone and Bones; D002132:Calcium Radioisotopes; D004583:Electrons; D005720:Gamma Rays; D006801:Humans; D008297:Male; D010761:Phosphorus Radioisotopes; D011829:Radiation Dosage; D011868:Radioisotopes; D013326:Strontium Radioisotopes; D015021:Yttrium Radioisotopes
D002132:Calcium Radioisotopes; D010761:Phosphorus Radioisotopes; D011868:Radioisotopes; D013326:Strontium Radioisotopes; D015021:Yttrium Radioisotopes; D001608:Beryllium