title: Evidence for the role of a trypsin-like enzyme in the hamster sperm acrosome reaction.
abstract: Acrosome reactions occurring in vitro in hamster sperm capacitated by bovine follicular fluid were severly inhibited by four synthetic trypsin inhibitors and by Zn2+. Three polypeptide trypsin inhibitors and a synthetic chymotrypsin inhibitor did not inhibit the acrosome reaction, and Ca2+ overcame the inhibition by Zn2+. These results suggest that a trypsin-like enzyme (possibly acrosin) plays a role in the acrosome reaction.
mesh_terms: D000176:Acrosin / Q000378:metabolism; D000177:Acrosome / Q000187:drug effects / Q000201:enzymology*; D000818:Animals; D001550:Benzamidines / Q000494:pharmacology; D006224:Cricetinae; D005260:Female; D008297:Male; D013075:Sperm Capacitation; D013081:Sperm Motility / Q000187:drug effects; D013094:Spermatozoa / Q000201:enzymology*; D014357:Trypsin / Q000378:metabolism*; D014361:Trypsin Inhibitors / Q000494:pharmacology; D015032:Zinc / Q000494:pharmacology
chemical_list: D001550:Benzamidines; D014361:Trypsin Inhibitors; D000176:Acrosin; D014357:Trypsin; D015032:Zinc