title: Intracranial bleeding associated with urokinase therapy for acute ischemic hemispheral stroke.
abstract: Four patients undergoing urokinase infusion therapy for acute occlusive cerebrovascular disease had intracerebral hemorrhage in the ischemic hemisphere. Three patients died during the acute phase of their illness and an autopsy was performed on two. The pathogenesis of cerebral bleeding in these case reports is discussed.
mesh_terms: D000368:Aged; D001921:Brain / Q000098:blood supply / Q000473:pathology; D002543:Cerebral Hemorrhage / Q000139:chemically induced*; D002561:Cerebrovascular Disorders / Q000188:drug therapy* / Q000473:pathology; D010450:Endopeptidases / Q000009:adverse effects*; D005260:Female; D006801:Humans; D007511:Ischemia / Q000188:drug therapy; D008297:Male; D014568:Urokinase-Type Plasminogen Activator / Q000009:adverse effects*
chemical_list: D010450:Endopeptidases; D014568:Urokinase-Type Plasminogen Activator