title: Efficacy of divided doses of fospirate against immature Echinococcus granulosus infections in dogs.
abstract: Seventy dogs were used to evaluate efficacy of divided doses of fospirate against immature Echinococcus granulosus infections in dogs. Dose rates of 10 to 80 mg/kg given on 1 or 2 occasions resulted in the clearance of 70.6 to 94.5% of expected worm numbers. At least 3 treatments may be required before dogs can be free from E granulosus. Vomiting, which occurred in dogs given doses of 40 mg or more/kg, seemed to interfere with anthelmintic efficacy in some dogs.
mesh_terms: D000818:Animals; D000871:Anthelmintics / Q000008:administration & dosage* / Q000009:adverse effects / Q000627:therapeutic use; D004283:Dog Diseases / Q000188:drug therapy*; D004285:Dogs; D004443:Echinococcosis / Q000188:drug therapy / Q000662:veterinary*; D009943:Organophosphorus Compounds / Q000008:administration & dosage*; D011725:Pyridines / Q000008:administration & dosage*
chemical_list: D000871:Anthelmintics; D009943:Organophosphorus Compounds; D011725:Pyridines; C010964:fospirate