Urinary hydroxyproline values following continuous and intermittent administration of prednisolone in children.
The administration of 2 mg/kg body weight of prednisolone daily in divided doses to 5 healthy children aged 5-7 years resulted in a significant decrease in the amount of total urinary hydroxyproline (HOP) which was restored to pretreatment levels two weeks after discontinuation of the drug. On the other hand, the administration of 2 mg/kg body weight of prednisolone in a single dose on alternate days (every-other-day) to two children and for a period of 10 days caused insignificant alterations in the amount of urinary HOP.
D002648:Child; D002675:Child, Preschool; D004305:Dose-Response Relationship, Drug; D006801:Humans; D006909:Hydroxyproline / Q000652:urine*; D011239:Prednisolone / Q000008:administration & dosage / Q000494:pharmacology*; D013997:Time Factors
D011239:Prednisolone; D006909:Hydroxyproline