Leukocyte and serum alkaline phosphatase after hip arthroplasty, synovectomy of the knee and fracture.
The alkaline phosphatase in leukocytes (LAP) was measured in patients who had undergone various types of total arthroplasty of the hip, in patients who had undergone synovectomy and in whom tibial fractures had been treated conservatively. The LAP-Score increased rapidly and reached a maximum within a few days and returned to original levels after 14 days both after soft tissue trauma and skeletal trauma. The size of the maximal increase appears to vary only with the severity of the trauma. LAP was not found to be correlated with the increase in alkaline phosphatase in the serum. The increase in serum alkaline phosphatase occurred much later and decreased much slower and occurred only after skeletal trauma. The increase in alkaline phosphatase in the serum appears to vary with severity of skeletal trauma. A significant difference in LAP (P less than 0.05) was found between patients operated upon with total arthroplasty with success and those with deep infection. The difference between these two groups was, however, larger (P less than 0.01) regarding ESR and CRP.
D000328:Adult; D000368:Aged; D000469:Alkaline Phosphatase / Q000097:blood*; D001178:Arthroplasty; D002097:C-Reactive Protein / Q000097:blood; D006615:Hip / Q000601:surgery*; D006801:Humans; D007719:Knee Joint / Q000601:surgery*; D007962:Leukocytes / Q000201:enzymology*; D008875:Middle Aged; D000074402:Synovectomy; D013978:Tibial Fractures / Q000201:enzymology*
D002097:C-Reactive Protein; D000469:Alkaline Phosphatase