Acute gastric ulcer formation in response to electrical vagal stimulation in rats.
Intermittent electrical stimulation of the left cervical vagus increased intragastric pressure and induced a 100% incidence of haemorrhagic ulcers in the glandular mucosa of rat stomachs. Atropine pretreatment of sub-diaphragmatic vagotomy prevented these effects. The findings substantiate the idea that stress-induced glandular ulcers result from vagal-mediated increased gastric contractions.
D000818:Animals; D001285:Atropine / Q000494:pharmacology; D001794:Blood Pressure / Q000187:drug effects; D004558:Electric Stimulation; D008297:Male; D051381:Rats; D013276:Stomach Ulcer / Q000209:etiology* / Q000503:physiopathology; D014630:Vagus Nerve / Q000502:physiology*
D001285:Atropine