Antidepressant and anticonvulsant activity of 1-(5-phenyl-4-oxazolin-2-yl)-4-substituted piperazines.
1-(5-Phenyl-4-oxo-2-oxazolin-2-yl)-4-substituted cinnamoylpiperazines and 1-(5-phenyl-4-oxo-2-oxazolin-2-yl)-4-carbamoylpiperazine and derivatives were synthesized and evaluated for antidepressant activity in the mouse Dopa potentiation test. 1-(5-Phenyl-4-oxo-2-oxazolin-2-yl)-4-carbamoylpiperazine and derivatives were further evaluated for anticonvulsant activity in the audiogenic seizure test in mice.
D000161:Acoustic Stimulation; D000818:Animals; D000927:Anticonvulsants / Q000138:chemical synthesis*; D000928:Antidepressive Agents / Q000138:chemical synthesis*; D001522:Behavior, Animal / Q000187:drug effects; D004295:Dihydroxyphenylalanine / Q000494:pharmacology; D051379:Mice; D010080:Oxazoles / Q000138:chemical synthesis / Q000494:pharmacology; D010389:Pemoline / Q000494:pharmacology; D010879:Piperazines / Q000138:chemical synthesis* / Q000494:pharmacology; D012640:Seizures / Q000517:prevention & control
D000927:Anticonvulsants; D000928:Antidepressive Agents; D010080:Oxazoles; D010879:Piperazines; D004295:Dihydroxyphenylalanine; D010389:Pemoline