Interactions of colony stimulating factors, other modulating cytokines and hematopoietic progenitor cells. Laboratory and clinical studies.
Blood cell production is regulated by a complex interacting network of stem and progenitor cells, from which all the blood forming elements are derived, and the effects of cytokines which can up- or down-modulate proliferation or self-renewal of stem and progenitor cells (1,2). This report reviews in brief recent information on the characteristics of human umbilical cord blood progenitor cells, the effects of the potent co-stimulating molecule, steel factor, and the myelosuppressive effects of macrophage inflammatory protein 1 alpha and other members of this latter group of molecules termed cytokines. In vitro as well as preclinical and clinical in vivo effects are covered.
D003115:Colony-Stimulating Factors / Q000494:pharmacology*; D016207:Cytokines / Q000494:pharmacology*; D005312:Fetal Blood / Q000166:cytology; D016298:Hematopoietic Cell Growth Factors / Q000494:pharmacology; D006412:Hematopoietic Stem Cells / Q000187:drug effects* / Q000502:physiology; D006801:Humans; D019089:Stem Cell Factor
D003115:Colony-Stimulating Factors; D016207:Cytokines; D016298:Hematopoietic Cell Growth Factors; D019089:Stem Cell Factor