Genetic and immunological mechanisms in the pathogenesis of systemic lupus erythematosus.
Recent research in systemic lupus erythematosus and animal models of lupus has provided new insight into the pathogenesis of this complex autoimmune disease. Progress has been made towards understanding the genetic contributions to disease susceptibility and induction, as well as towards elucidation of the lymphocyte abnormalities involved in pathogenic autoantibody production.
D000818:Animals; D000954:Antigens, Surface / Q000235:genetics; D001323:Autoantibodies / Q000276:immunology; D001402:B-Lymphocytes / Q000276:immunology; D004195:Disease Models, Animal; D005802:Genes, MHC Class II / Q000235:genetics; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000235:genetics* / Q000276:immunology*; D051379:Mice; D013601:T-Lymphocytes / Q000276:immunology; D019014:fas Receptor
D000954:Antigens, Surface; D001323:Autoantibodies; D019014:fas Receptor