Free radical theory of aging: inhibition of amyloidosis in mice by antioxidants; possible mechanism.
The antioxidants, alpha-tocopherol acetate and a quinolone derivative (Santoquin), inhibited the development of amyloidosis when added to the diet of casein-injected C3HeB/FeJ male mice. Santoquin, and to a lesser extent butylated hydroxytoluene (BHT), also depressed the appearance of a plasma protein fraction in these mice; the effect of alpha-tocopherol was not determined. Consideration of the current knowledge of amyloid, in the light of these antioxidant studies, prompted the following hypothesis. Amyloidosis is largely the result of an enhanced rate of oxidative degradation of a connective-tissue glycoprotein(s) coupled with oxidative/enzymatic changes in the plasma, both of the tissue-derived substances and of immunoglobulins, to form the amyloid fibril protein subunits (AL and AA) which subsequently aggreagate to form the amyloid fibrils.
D000375:Aging; D000682:Amyloid / Q000378:metabolism; D000686:Amyloidosis / Q000139:chemically induced / Q000517:prevention & control*; D000818:Animals; D000975:Antioxidants / Q000627:therapeutic use*; D002084:Butylated Hydroxytoluene / Q000627:therapeutic use; D002364:Caseins; D005015:Ethoxyquin / Q000627:therapeutic use; D005609:Free Radicals; D008297:Male; D051379:Mice; D008809:Mice, Inbred C3H; D011506:Proteins / Q000378:metabolism; D014810:Vitamin E / Q000627:therapeutic use
D000682:Amyloid; D000975:Antioxidants; D002364:Caseins; D005609:Free Radicals; D011506:Proteins; D014810:Vitamin E; D002084:Butylated Hydroxytoluene; D005015:Ethoxyquin