The role of alpha- and beta-adrenergic effects in the action of adrenaline on renal lithium elimination in adrenalectomized rats.
Repeated s.c. injections of L-adrenaline (4 X 0.5 mg/kg body weight) increased the urinary clearance of lithium in intact rats and in adrenalectomized animals. Adrenaline also increased the fractional excretion of lithium in adrenalectomized rats; an effect that was prevented by repeated s.c. injections of the alpha-adrenergic blocking agent phentolamine (4 X 1 mg/kg body weight). When administered alone, propranolol and phentolamine decreased the urinary clearance of lithium in adrenalectomized rats. The drug-induced changes in the urinary clearance of lithium were not directly related to the effects of the drugs on the urinary elimination of sodium, potassium, creatine and water. The results suggest that the action of adrenaline on renal lithium elimination in adrenalectomized rats might be mediated by alpha-adrenergic receptors.
D000311:Adrenal Glands / Q000502:physiology; D000315:Adrenalectomy; D000818:Animals; D004837:Epinephrine / Q000494:pharmacology*; D007668:Kidney / Q000502:physiology*; D007677:Kidney Function Tests; D008094:Lithium / Q000097:blood / Q000378:metabolism* / Q000652:urine; D008297:Male; D010646:Phentolamine / Q000494:pharmacology; D011433:Propranolol / Q000494:pharmacology; D051381:Rats; D011941:Receptors, Adrenergic / Q000187:drug effects*
D011941:Receptors, Adrenergic; D008094:Lithium; D011433:Propranolol; D004837:Epinephrine; D010646:Phentolamine