Kidney stone matrix. Differences in acidic protein composition.
Organic matrices from kidney stones of several mineral compositions (calcium oxalate, uric acid, and apatite-struvite) were isolated and found to contain an abundance of acidic amino acids. The calcium oxalate stones contained 50% aspartic and glutamic acid residues while the uric acid stones contained over 65%. The apatite-struvite stones had only 30% of these two amino acid residues and also contained 20% glycine residues. Since the specific amino acid composition differed for stones of different mineral content, it was felt that the organic matrix might play the role of a nucleating agent.
D000596:Amino Acids / Q000032:analysis; D001031:Apatites / Q000032:analysis; D002118:Calcium / Q000032:analysis*; D002130:Calcium Phosphates / Q000032:analysis*; D006801:Humans; D007669:Kidney Calculi / Q000378:metabolism*; D008274:Magnesium / Q000032:analysis; D008970:Molecular Weight; D010070:Oxalates / Q000032:analysis*; D010710:Phosphates / Q000032:analysis; D011506:Proteins / Q000032:analysis*; D000644:Quaternary Ammonium Compounds / Q000032:analysis; D014527:Uric Acid / Q000032:analysis*
D000596:Amino Acids; D001031:Apatites; D002130:Calcium Phosphates; D010070:Oxalates; D010710:Phosphates; D011506:Proteins; D000644:Quaternary Ammonium Compounds; D014527:Uric Acid; D008274:Magnesium; D002118:Calcium