Observations in vitro regarding the mechanism of the cell destruction by stimulated lymphocytes.
In contrast to other cells stimulated lymphocytes release substances probably cytotoxic which are incorporated by the target cells. The cellular material is released by tearing off parts of fine processes which the lymphocytes extend on to the surface of the target cells. This explains the before mentioned observations that the cell destruction mediated by lymphocytes depends absolutely on a close contact between the lymphocytes and the target cells.
D000937:Antigen-Antibody Reactions; D002462:Cell Membrane / Q000648:ultrastructure; D002478:Cells, Cultured / Q000276:immunology; D003601:Cytotoxicity Tests, Immunologic; D006367:HeLa Cells / Q000276:immunology; D006801:Humans; D008213:Lymphocyte Activation; D008214:Lymphocytes / Q000276:immunology* / Q000648:ultrastructure; D009940:Organoids / Q000648:ultrastructure