Ovine placental lactogen: acute effects on intermediary metabolism in pregnant and non-pregnant sheep.
The intravenous administration of ovine placental lactogen to pregnant and non-pregnant sheep produced significant acute decreases in plasma free fatty acid, glucose and amino nitrogen concentrations. Plasma insulin concentrations decreased 1 h after administration of ovine placental lactogen and then increased significantly above baseline concentrations. The results suggest that, like human placental lactogen, ovine placental lactogen is important in the modulation of intermediary metabolism during pregnancy. The sheep is an excellent animal model for the investigation of the physiology of placental lactogen.
D000596:Amino Acids / Q000097:blood; D000818:Animals; D001786:Blood Glucose / Q000032:analysis; D004305:Dose-Response Relationship, Drug; D005230:Fatty Acids, Nonesterified / Q000097:blood*; D005260:Female; D007328:Insulin / Q000097:blood*; D007743:Labor, Obstetric; D010928:Placental Lactogen / Q000494:pharmacology*; D011247:Pregnancy; D011270:Pregnancy, Animal; D012756:Sheep
D000596:Amino Acids; D001786:Blood Glucose; D005230:Fatty Acids, Nonesterified; D007328:Insulin; D010928:Placental Lactogen