title: Damage of skeletal muscle in rats by immunoglobulins. I. Pathophysiological data and lightmicroscopic observations.
abstract: An experimental model of the autoimmune process was developed to study the pathophysiological and structural changes in immunomyopathies. Immune-sera derived from three muscle proteins--myofibril, myosin and actin--produced immunomyopathies for study. The pathophysiological data show that the general muscle efficiency began to decrease with the early stages of treatment and reflected a severe disorder to muscle function with the progression of time. Parallel changes were also observed by light microscopy.
mesh_terms: D000818:Animals; D001327:Autoimmune Diseases / Q000503:physiopathology*; D004195:Disease Models, Animal; D005221:Fatigue; D005260:Female; D007106:Immune Sera / Q000008:administration & dosage; D007136:Immunoglobulins / Q000008:administration & dosage / Q000032:analysis; D009124:Muscle Proteins / Q000276:immunology*; D009132:Muscles / Q000187:drug effects / Q000503:physiopathology; D009135:Muscular Diseases / Q000276:immunology / Q000503:physiopathology*; D009157:Myasthenia Gravis / Q000276:immunology; D051381:Rats; D011919:Rats, Inbred Strains; D012133:Respiratory Paralysis / Q000139:chemically induced; D013390:Succinylcholine / Q000494:pharmacology
chemical_list: D007106:Immune Sera; D007136:Immunoglobulins; D009124:Muscle Proteins; D013390:Succinylcholine