title: Systemic lupus erythematosus in twin sisters following ten years of hyperglobulinemic purpura (Waldenström).
abstract: Uniovular twin sisters have been diagnosed 10 years ago as having hyperglobulinemic purpura (Waldenström) at age 12. The diagnosis was documented by purpura of the lower extremities, increased gamma-globulin after serum electrophoresis, and increased 7S component upon ultracentrifugation. In addition, there was an elevated ESR, a positive rheumatoid arthritis latex test, and their LE prep. was negative at that time. At a later date, however, both of them developed polyarthritis. After 9 years for the one and 10 years for the other, their LE prep. became strongly and constantly positive, while their gamma-globulin remained within abnormal limits.
mesh_terms: D001798:Blood Proteins / Q000032:analysis; D002648:Child; D004200:Diseases in Twins; D005260:Female; D005838:Genotype; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000097:blood / Q000209:etiology / Q000235:genetics*; D011694:Purpura, Hyperglobulinemic / Q000150:complications / Q000235:genetics*
chemical_list: D001798:Blood Proteins