title: Parameter estimation in studying circadian rhythms.
abstract: In the model under consideration for the circadian rhythm study there are three unknown physiological parameters involved: the level, the amplitude and the phase. This paper concerns the estimation of the group level, group amplitude and group phase of a certain group of individuals based on their time series data. Special attention is paid to the amplitude and phase parameters, and solutions are obtained for both the small-sample and the large-sample cases.
mesh_terms: D002940:Circadian Rhythm; D008433:Mathematics; D008954:Models, Biological