Hepatitis B virus infection in the Wiskott-Aldrich syndrome.
Testing of paired serum samples of 12 children with the Wiskott-Aldrich syndrome for the presence of hepatitis B surface antigen (HBsAg) antibody to HB, Ag, and antibody to the hepatitis B core antigen revealed evidence of hepatitis B virus infection in three. None of the three, however, developed overt clinical hepatitis or the chronic HBsAg carrier state. These data suggest that the immunologic defects seen in the Wiskott-Aldrich syndrome permit adequate immune responses to the hepatitis B virus and do not predispose to the chronic HBsAg carrier state.
D000914:Antibodies, Viral / Q000032:analysis; D000956:Antigens, Viral / Q000032:analysis; D002908:Chronic Disease; D006509:Hepatitis B / Q000150:complications* / Q000276:immunology; D006515:Hepatitis B virus / Q000276:immunology; D006801:Humans; D008297:Male; D014923:Wiskott-Aldrich Syndrome / Q000150:complications* / Q000276:immunology
D000914:Antibodies, Viral; D000956:Antigens, Viral