[Histochemical properties of the heparin-protein complex of mast cells and the state of the blood coagulating system in a primary lesion focus of non-specific ulcerative colitis].
Histochemical characteristics of polyanionic-cationic complex of mast cells, morphology of the microcirculatory bed of the large intestine, and a functional state of the coagulating blood system in the general blood flow and in the focus of primary inflammation were studied in patients with nonspecific ulcerative colitis. In the mast cells of the diseases intestine there was found a heparin-albuminous complex, saline resistance of the latter considerably exceed that in the norm. In the focus of primary inflammation deficit of active heparin and rise in coagulating characteristics of the blood were revealed. In the microcirculatory bed of the intestine angioniatosis, stasis, and thrombosis were observed. Impairment of complex-formation in the mast cells with appearance in their cytoplasm of the resistant heparin-albuminous complex apparently caused the local deficit of heparin and initiated the thrombogenesis in the microcirculatory bed. Thrombosis of the vessels led to hemorrhages, bleeding, disorder of the vascular wall feeding and its necrosis.
D000328:Adult; D001777:Blood Coagulation; D003093:Colitis, Ulcerative / Q000097:blood / Q000378:metabolism* / Q000473:pathology; D005342:Fibrinolysis; D006493:Heparin / Q000378:metabolism; D006651:Histocytochemistry; D006801:Humans; D007420:Intestine, Large / Q000098:blood supply; D008407:Mast Cells / Q000378:metabolism*; D008833:Microcirculation / Q000473:pathology; D011506:Proteins / Q000378:metabolism
D011506:Proteins; D006493:Heparin
Gistokhimicheskie svoĭstva geparino-belkovogo kompleksa tuchnykh kletok i sostoianie svertyvaiushcheĭ sistemy krovi v ochage pervichnogo porazheniia pri nespetsificheskom iazvennom kolite