Lipid-F1 nucleohistone interactions.
High concentrations of phospholipids determine destabilization of F1 histone-DNA complex at the weight ratios, histone:DNA, 0.8:1 and 1:1, but low concentrations cause only negligible destabilization. Cholesterol at high weight ratios has little effect on nucleohistone stability. Only linolenic acid of the fatty acids used reproduces similar changes in the thermal stability of F1 histone-DNA complex as phospholipids. The type of interaction of phospholipids with the F1 histone-DNA complex is analyzed, and the involvement of phospholipids in DNA replication in vivo is discussed.
D001665:Binding Sites; D002784:Cholesterol; D003852:Deoxyribonucleoproteins; D004355:Drug Stability; D006657:Histones; D007700:Kinetics; D009698:Nucleoproteins; D010743:Phospholipids; D011485:Protein Binding; D013329:Structure-Activity Relationship; D013696:Temperature
D003852:Deoxyribonucleoproteins; D006657:Histones; D009698:Nucleoproteins; D010743:Phospholipids; D002784:Cholesterol