Physostigmine as a discriminative cue in rats.
Rats, trained to respond differentially in a T-maze contingent upon the presence or absence of physostigmine (0.50 mg/kg), showed a reversal of drug responding when physostigmine (0.50 mg/kg) was given simultaneously with the anticholinergic ditran (dose range: 0.80-3.20 mg/kg). Testing the quaternary anticholinesterase neostigmine (0.50 mg/kg) resulted in no drug responding which indicates a central site of action for the physostigmine discrimination.
D000109:Acetylcholine / Q000037:antagonists & inhibitors; D000818:Animals; D001362:Avoidance Learning / Q000187:drug effects; D004192:Discrimination, Psychological / Q000187:drug effects*; D004338:Drug Combinations; D006016:Glycolates / Q000494:pharmacology; D008297:Male; D009388:Neostigmine / Q000494:pharmacology; D010830:Physostigmine / Q000494:pharmacology*; D010880:Piperidines / Q000494:pharmacology; D011759:Pyrrolidines / Q000494:pharmacology; D051381:Rats; D013997:Time Factors
D004338:Drug Combinations; D006016:Glycolates; D010880:Piperidines; D011759:Pyrrolidines; D009388:Neostigmine; C001621:1-ethyl-2-pyrrolidinylmethyl-alpha-phenylcyclopentylglycolate, 1-ethyl-3-piperidyl-alpha-phenylcyclopentylglycolate drug combination; D010830:Physostigmine; D000109:Acetylcholine