The interaction of glutamic and aspartic acids with excitatory amino acid receptors in the mammalian central nervous system.
Firing rates of single thalamic neurones of the cat and the rat have been measured as functions of the currents used to apply glutamic and aspartic acids electrophoretically. Hill plots of the data suggest that three amino acid molecules are probably required to activate an excitatory receptor.
D000596:Amino Acids / Q000502:physiology*; D000818:Animals; D001224:Aspartic Acid / Q000494:pharmacology*; D002415:Cats; D004347:Drug Interactions; D005971:Glutamates / Q000494:pharmacology*; D009474:Neurons / Q000187:drug effects; D051381:Rats; D011955:Receptors, Drug / Q000187:drug effects*; D013788:Thalamus / Q000187:drug effects*
D000596:Amino Acids; D005971:Glutamates; D011955:Receptors, Drug; D001224:Aspartic Acid