Synthesis and central nervous system depressant activity of some bicyclic amides.
A series of aryl bicyclic analogs of succinimide and glutarimide was prepared and evaluated for CNS depressant activity. The 8a-aryl-3,4,6,7,8,8a-hexahydro-2H-pyrrolo[2,1-beta][1,3]oxazin-6-ones possessed the best overall spectrum of activity relative to the standard agents glutethimide and phenobarbital.
D000577:Amides / Q000138:chemical synthesis* / Q000494:pharmacology / Q000633:toxicity; D000818:Animals; D000927:Anticonvulsants; D001522:Behavior, Animal / Q000187:drug effects; D001952:Bridged-Ring Compounds / Q000138:chemical synthesis*; D002490:Central Nervous System / Q000187:drug effects*; D003864:Depression, Chemical; D007928:Lethal Dose 50; D008297:Male; D051379:Mice; D051381:Rats; D012018:Reflex / Q000187:drug effects
D000577:Amides; D000927:Anticonvulsants; D001952:Bridged-Ring Compounds