H-2 associated differences in the weight of some androgen influenced organs in (C57BL/10ScSnPh X AKR/J) F2 individuals.
We have followed the possible influence of H-2 system on the differences in the relative weights of testes, vesicular gland and thymus in animals of a segregating (B10 X AKR) F2 generation. H-2b/H-2b male mice had significantly higher values of relative vesicular gland weight and significantly lower values of relative testes weight than H-2k/H-2k males. No differences in the relative thymus weight were found between these two groups of animals. The differences are caused by a complex effect of the H.2 associated genetic factor(s) because they influence simultaneously the body weight and the organ weights, the two indicators being mutually dependent to some extent.
D000728:Androgens / Q000378:metabolism*; D000818:Animals; D000917:Antibody Formation; D001835:Body Weight; D005838:Genotype; D006648:Histocompatibility; D006649:Histocompatibility Antigens / Q000032:analysis; D008297:Male; D051379:Mice; D008806:Mice, Inbred AKR; D008810:Mice, Inbred C57BL; D009929:Organ Size; D012669:Seminal Vesicles / Q000276:immunology / Q000378:metabolism; D013737:Testis / Q000276:immunology / Q000378:metabolism; D013950:Thymus Gland / Q000276:immunology / Q000378:metabolism
D000728:Androgens; D006649:Histocompatibility Antigens