Application of the lod method to the detection of linkage between a quantitative trait and a qualitative marker: a simulation experiment.
Simulation experiments were performed to assess the power of the lod method for detecting linkage between a quantitative trait and a qualitative marker. Using family data on the Amy2-Duffy linkage, it was found that linkage detection is feasible in certain limited circumstances. The same qualitative data yielded no evidence for a significant difference in male and female recombination fractions.
D000681:Amylases; D001789:Blood Group Antigens; D004375:Duffy Blood-Group System; D005260:Female; D005796:Genes; D008040:Genetic Linkage; D006801:Humans; D008297:Male; D008954:Models, Biological; D010641:Phenotype; D011995:Recombination, Genetic; D013223:Statistics as Topic
D001789:Blood Group Antigens; D004375:Duffy Blood-Group System; D000681:Amylases