Effect of Crude and Purified hCG on Lymphocyte Blastogenesis.
Crude APL hCG completely inhibited blastogenesis induced by phytohemagglutinin, pokeweed mitogen, or concanavalin A in normal lymphocytes and lymphocytes obtained from cancer patients. Phenol in quantities comparable to its concentration in commercial lyophilized APL hCG also completely inhibited all three mitogenic responses. By contrast, similar doses of highly purified hCG had no inhibitory effect; higher concentrations produced only slight inhibition. Beta-hCG had a partial (less than 50%) inhibitory effect that was dose-independent and nonreproducible.
D006063:Chorionic Gonadotropin / Q000008:administration & dosage / Q000302:isolation & purification / Q000494:pharmacology*; D003208:Concanavalin A / Q000494:pharmacology; D006801:Humans; D066298:In Vitro Techniques; D007785:Lactose / Q000494:pharmacology; D037102:Lectins / Q000494:pharmacology; D008213:Lymphocyte Activation / Q000187:drug effects*; D008214:Lymphocytes / Q000187:drug effects; D008934:Mitogens / Q000494:pharmacology; D010636:Phenols / Q000494:pharmacology*; D013936:Thymidine / Q000378:metabolism
D006063:Chorionic Gonadotropin; D037102:Lectins; D008934:Mitogens; D010636:Phenols; D003208:Concanavalin A; D007785:Lactose; D013936:Thymidine