title: Spironolactone and cytochrome P-450: impairment of steroid 21-hydroxylation in the adrenal cortex.
mesh_terms: D000302:Adrenal Cortex / Q000187:drug effects / Q000201:enzymology*; D000311:Adrenal Glands / Q000201:enzymology*; D000818:Animals; D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism*; D004285:Dogs; D006168:Guinea Pigs; D007700:Kinetics; D008297:Male; D011374:Progesterone / Q000494:pharmacology; D011817:Rabbits; D051381:Rats; D013045:Species Specificity; D013148:Spironolactone / Q000494:pharmacology*; D013250:Steroid Hydroxylases / Q000378:metabolism*
chemical_list: D013148:Spironolactone; D011374:Progesterone; D003577:Cytochrome P-450 Enzyme System; D013250:Steroid Hydroxylases