Effect of radiophosphorus on the developing endocrine glands of Swiss albino mice. I. A study on the thyroid gland.
A study has been made on the effects of P-32 on the developing thyroid gland of Swiss albino mice. The series of experiments reveal that: (I) P-32 at the dose rate of 1.0 muCi/g body-weight to the seven-day pregnant mouse has almost no effect on the 18-day foetus or as late as 14-day postnatal thyroid. (II) With the same dose, when given to one-day-old mouse, signs of dead mitotic figures are noticed. The effects are more pronounced in the beginning, but after the fourth week no morphological changes are seen. (III) When a seven-day-old animal is injected with the same dose, dead cells are found in the earlier stages followed by the damage to the vascular structure of the epithelium. (IV) The 14-day injected group shows damage to the epithelium in the form of condensed nuclei and loss of colloid from the follicles. Replacement of follicles by fatty degeneration is evident. (V) A maximum susceptibility to P-32 irradiation is shown by 21-day-old injected animals, where epithelial desquamation and replacement of follicles by fatty degeneration are easily marked one week after the injection. (VI) In the last group, where P-32 is given at the 28th day after parturition, there may be a tendency of the thickening of the blood vessels. (VII) The females show a greater damage to P-32 injection than the males in the postnatal period studied.
D000367:Age Factors; D000818:Animals; D004848:Epithelium / Q000528:radiation effects; D005260:Female; D051379:Mice; D010761:Phosphorus Radioisotopes; D011829:Radiation Dosage; D011830:Radiation Effects; D012737:Sex Factors; D013961:Thyroid Gland / Q000254:growth & development / Q000528:radiation effects*
D010761:Phosphorus Radioisotopes