title: Synthesis and biological activity in the GPI test of scyliorhinin I and its Val7 and Ile7 analogs.
abstract: Scyliorhinin I, a decapeptide, of tachykinin family, and its two analogs containing Val or Ile in position 7, have been synthesized using the solid-phase method, and tested for agonistic activity on isolated guinea pig ileum. Both analogs were slightly more active than scyliorhinin I, but they were significantly less potent than substance P.
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D006168:Guinea Pigs; D007082:Ileum; D007532:Isoleucine / Q000737:chemistry; D008969:Molecular Sequence Data; D009119:Muscle Contraction / Q000187:drug effects; D009130:Muscle, Smooth / Q000187:drug effects*; D013329:Structure-Activity Relationship; D013373:Substance P / Q000494:pharmacology; D015320:Tachykinins / Q000138:chemical synthesis / Q000494:pharmacology*; D014633:Valine / Q000737:chemistry
chemical_list: D015320:Tachykinins; D007532:Isoleucine; C048918:scyliorhinin I; D013373:Substance P; D014633:Valine