Vitamin E supplementation and glutathione peroxidase activity.
Both excess dietary vitamin E and vitamin E deficiency in rats can significantly depress the activity of GSH peroxidase in liver and plasma of rats. Of all the six levels of vitamin E tested in this study, the dietary level of vitamin E found to maintain the maximum activity of GSH peroxidase in tissues of rats was somewhere between 25 and 250 IU/kg diet. This study conclusively indicates that the excess dietary vitamin E represses GSH peroxidase activity.
D000818:Animals; D001835:Body Weight / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D005260:Female; D005979:Glutathione Peroxidase / Q000097:blood / Q000378:metabolism*; D008099:Liver / Q000033:anatomy & histology / Q000201:enzymology*; D009929:Organ Size / Q000187:drug effects; D010544:Peroxidases / Q000378:metabolism*; D011506:Proteins / Q000378:metabolism; D051381:Rats; D012995:Solubility; D014599:Uterus / Q000033:anatomy & histology / Q000201:enzymology*; D014810:Vitamin E / Q000494:pharmacology*
D011506:Proteins; D014810:Vitamin E; D010544:Peroxidases; D005979:Glutathione Peroxidase