Alteration of the response of guinea pigs to freund's complete adjuvant by ascaris extract: a preliminary histologic study.
Freund's adjuvant has been asserted to cause systemic complications in man similar to those occurring with B.C.G. vaccine. In search of factors predisposing to such complications of this vaccine, the potential role of a coexisting parasitic infestation was considered. A potentiating effect of the ascaris antigen on the pathological changes produced in guinea pigs by intraperitoneally injected Freund's complete adjuvant was noted. The pertinency of this observation to immunotherapy of cancer with B.C.G. is purely speculative.
D000818:Animals; D001200:Ascaris; D005620:Freund's Adjuvant; D006099:Granuloma / Q000139:chemically induced* / Q000473:pathology; D006168:Guinea Pigs; D008099:Liver / Q000473:pathology; D008168:Lung / Q000098:blood supply / Q000473:pathology; D008171:Lung Diseases / Q000139:chemically induced* / Q000473:pathology; D008198:Lymph Nodes / Q000473:pathology; D008206:Lymphatic Diseases / Q000139:chemically induced* / Q000473:pathology; D011651:Pulmonary Artery / Q000473:pathology; D013154:Spleen / Q000473:pathology
D005620:Freund's Adjuvant