title: In vitro penetration of topical antiseptics through eschar of burn patients.
abstract: The ability of topical antiseptics to penetrate eschar of burn patients was determined by the agar diffusion technique. Gentamicin sulfate, mafenide acetate, nitrofurazone, povidone-iodine, silver nitrate, and silver sulfadiazine were tested against clinical isolates of Candida albicans, Staphylococcus, Streptococcus, and gram-negative bacilli including Pseudomonas aeruginosa. In practically all instances, the diameters of the zones of inhibition observed using eschar were comparable to those obtained with filter-paper discs. This finding showed that the antimicrobial agents could penetrate eschar and retain their effectiveness after penetration.
mesh_terms: D000891:Anti-Infective Agents, Local / Q000494:pharmacology*; D001424:Bacterial Infections / Q000517:prevention & control; D002056:Burns / Q000150:complications; D002177:Candidiasis / Q000517:prevention & control; D005839:Gentamicins / Q000494:pharmacology; D006801:Humans; D066298:In Vitro Techniques; D008272:Mafenide / Q000494:pharmacology; D009583:Nitrofurazone / Q000494:pharmacology; D011206:Povidone-Iodine / Q000494:pharmacology; D012835:Silver Nitrate / Q000494:pharmacology; D013411:Sulfadiazine / Q000494:pharmacology; D014946:Wound Infection / Q000517:prevention & control
chemical_list: D000891:Anti-Infective Agents, Local; D005839:Gentamicins; D013411:Sulfadiazine; D008272:Mafenide; D011206:Povidone-Iodine; D012835:Silver Nitrate; D009583:Nitrofurazone