title: Improved method for production of attenuated Venezuelan equine encephalomyelitis (TC-83 strain) vaccine.
abstract: Primary chicken embryo cell cultures were evaluated a s an alternate cell system for the production of attenuated Venezuelan equine encephalomyelitis (TC-83 strain) vaccine. The TC-83 strain virus was shown to remain stable during 10 serial passages in chicken embryo cell culture with regard to plaque size and morphology, virus yield, potency, and virulence for mice and hamsters.
mesh_terms: D000818:Animals; D002642:Chick Embryo; D006224:Cricetinae; D046508:Culture Techniques; D004666:Encephalitis Virus, Venezuelan Equine / Q000254:growth & development / Q000276:immunology* / Q000472:pathogenicity; D005069:Evaluation Studies as Topic; D005318:Fetal Heart; D006168:Guinea Pigs; D007120:Immunochemistry; D051379:Mice; D014613:Vaccines, Attenuated; D014765:Viral Vaccines; D014774:Virulence
chemical_list: D014613:Vaccines, Attenuated; D014765:Viral Vaccines