[Acetylation reaction in mice in the normal state and in tumors].
Studies of peculiarities of acetylation with the use of sulfadimidine showed the distribution of female white non-bred mice into two groups - with high and low activity. In C3H/He mice a relatively high activity of sulfadimidine acetylation was observed, while in C57BL/He mice a low activity of acetylation was noted. The growth of transplanted melanoma B-16 in C57BL/He mice and sarcoma 37 and sarcoma 180 in non-bred mice resulted in an increased activity of sulfadimidine acetylation. The use of w-sodium methylpantothenate (an antagonist of pantothenic acid) failed to show an increased activity of sulfadimidine acetylation and inhibited the tumor growth.
D000107:Acetylation; D000818:Animals; D005260:Female; D008545:Melanoma / Q000378:metabolism*; D051379:Mice; D008809:Mice, Inbred C3H; D008810:Mice, Inbred C57BL; D009374:Neoplasms, Experimental / Q000378:metabolism; D010205:Pantothenic Acid / Q000037:antagonists & inhibitors; D012513:Sarcoma, Experimental / Q000378:metabolism*; D013418:Sulfamethazine / Q000378:metabolism*
D010205:Pantothenic Acid; D013418:Sulfamethazine
Reaktsii atsetilirovaniia u mysheĭ v norme i pri opukholiakh