Regional differences in the distribution of capsaicin-sensitive target-identified adult rat dorsal root ganglion neurons.
A retrograde labelling technique combined with a cobalt uptake assay in cultured adult rat dorsal root ganglion (DRG) neurons were applied to study the distribution of capsaicin sensitivity in relation to different peripheral targets. This study shows that there are regional differences between skin, skeletal muscle and urinary bladder; 20-30% of skin afferents, 40% of muscle afferents and 60% of bladder afferents were found to be capsaicin-senditive. This may reflect differences in the proportion of chemosensitive afferents innervating different peripheral tissues.
D000818:Animals; D002211:Capsaicin / Q000494:pharmacology*; D003035:Cobalt / Q000378:metabolism; D005727:Ganglia, Spinal / Q000166:cytology*; D006614:Hindlimb / Q000294:innervation; D007473:Ion Channels / Q000187:drug effects / Q000378:metabolism; D009412:Nerve Fibers / Q000187:drug effects; D009475:Neurons, Afferent / Q000187:drug effects* / Q000378:metabolism; D051381:Rats; D017207:Rats, Sprague-Dawley; D001743:Urinary Bladder / Q000294:innervation
D007473:Ion Channels; D003035:Cobalt; D002211:Capsaicin