[Determination of absolute configuration of amine compounds of pharmaceutical interest by means of measurement of circular dichroism].
The CD curves study of the pyridyl-N-oxide derivatives of some adrenergic and anorexigenic amines showed that the sign of the Cotton effect can be related to their absolute configuration. The obtained results confirm the absolute configuration of fenfluramine and nor-fenfluramine and suggest that the levo isomer of ortoxine has R-configuration.
D000588:Amines / Q000032:analysis*; D002942:Circular Dichroism; D005277:Fenfluramine / Q000032:analysis; D007536:Isomerism; D009682:Magnetic Resonance Spectroscopy; D010665:Phenylpropanolamine / Q000032:analysis; D013056:Spectrophotometry, Ultraviolet; D013057:Spectrum Analysis
D000588:Amines; D005277:Fenfluramine; D010665:Phenylpropanolamine
Determinazione della configurazione assoluta di composti amminici aventi interesse farmaceutico attraverso misure di dicroismo circolare