In vitro susceptibility comparisons and recommendations for oxolinic acid.
Minimal inhibitory concentration and disk diffusion susceptibility studies were carried out with oxolinic acid to determine a recommended disk content for disk susceptibility testing. Regression curve analyses were performed with disks containing 1, 2, and 5 mug of oxolinic acid. Data suggest that the 5-mug disk more satisfactorily fulfills requirements for susceptibility testing than the 1- or 2-mug disks evaluated. Ultraviolet spectral analysis studies for absorption maxima and extinction coefficients were done to verify the authenticity and concentration of oxolinic acid in the aqueous solutions studied.
D001419:Bacteria / Q000187:drug effects*; D004755:Enterobacteriaceae / Q000187:drug effects; D008826:Microbial Sensitivity Tests; D009268:Nalidixic Acid / Q000032:analysis; D010093:Oxolinic Acid / Q000032:analysis / Q000494:pharmacology*; D013056:Spectrophotometry, Ultraviolet; D013210:Staphylococcus / Q000187:drug effects
D009268:Nalidixic Acid; D010093:Oxolinic Acid