Immunohistochemical localization of somatostatin in endocrine cells of the rat stomach.
Using an immunohistochemical technique involving unlabeled antibody and the peroxidase-anti-peroxidase complex, we have localized somatostatin (or growth hormone-release inhibiting hormone), a hypothalamic hormone which can also inhibit gastrin secretion, in the rat stomach. Somatostatin was found to be present in a few cells in the mucosa of the pyloric antrum. These cells are characterized by the presence of secretory granules of about 150-250 nm in diameter and are probably endocrine cells.
D000818:Animals; D000937:Antigen-Antibody Reactions; D003594:Cytoplasmic Granules / Q000032:analysis / Q000648:ultrastructure; D008297:Male; D008854:Microscopy, Electron; D011708:Pylorus / Q000032:analysis; D051381:Rats; D013004:Somatostatin / Q000032:analysis* / Q000276:immunology*; D013270:Stomach / Q000032:analysis* / Q000166:cytology
D013004:Somatostatin