[Drug-protein interactions: physico-chemical study on the interactions between chlorpromazine and glutamate dehydrogenase].
The molecular basis of inhibition of glutamate dehydrogenase by chlorpromazine was studied by circular dichoroism, differential spectroscopy and fluorescence. Chlorpromazine appears to induce conformational changes of the enzyme at the position of aromatic amino acids, and tryptophan residues in particular are involved. On the other hand the secondary structure of the enzyme is not influenced by binding of the drug.
D001665:Binding Sites; D002746:Chlorpromazine / Q000378:metabolism*; D005453:Fluorescence; D005969:Glutamate Dehydrogenase / Q000037:antagonists & inhibitors*; D006801:Humans; D013056:Spectrophotometry, Ultraviolet
D005969:Glutamate Dehydrogenase; D002746:Chlorpromazine
Interazione farmaci-proteine: studi chimico-fisici sull'interazione di cloropromazina con glutammico deidrogenasi