[Experimental study of the action of the antitumor antibiotic reumycin on the macroorganism].
The side effect of reumycin, an antitumor antibiotic was studied experimentally. The average lethal dose for mice and rats on intravenous administration of the drug was 45.5 and 42.2 mg/kg respectively. When reumycin was administered to rats and dogs for prolong periods of time, an increase in the levels of total protein, urea nitrogen and inorganic phosphorus in the blood was observed, while the levels of hemoglobin and thrombocyte counts decreased, the process of the blood coagulation being slower. The changes in the ECG were similar to those observed in the myocardium dystrophy. The morphological changes in the organs were characterized by perivascular edema, swelling of the vessel walls and edema of the interstitial tissues.
D000818:Animals; D000903:Antibiotics, Antineoplastic / Q000633:toxicity*; D001769:Blood / Q000187:drug effects; D001808:Blood Vessels / Q000187:drug effects; D002319:Cardiovascular System / Q000187:drug effects; D002415:Cats; D004285:Dogs; D004305:Dose-Response Relationship, Drug; D004562:Electrocardiography; D005769:Gastrointestinal Motility / Q000187:drug effects; D007684:Kidney Tubules / Q000187:drug effects; D007928:Lethal Dose 50; D008198:Lymph Nodes / Q000187:drug effects; D051379:Mice; D009336:Necrosis; D011743:Pyrimidines / Q000633:toxicity; D011817:Rabbits; D051381:Rats; D013154:Spleen / Q000187:drug effects; D013997:Time Factors; D014227:Triazines / Q000633:toxicity*
D000903:Antibiotics, Antineoplastic; D011743:Pyrimidines; D014227:Triazines; C009169:reumycin
Eksperimental'noe izuchenie deĭstviia protivoopukholevogo antibiotika reumitsina na makroorganizm