Role of oxygen on growth rate and gene activity in cultured chick-embryo heart cells.
Environmental oxygen is shown to have a regulatory role in growth rate and the mechanism of gene de-repression in chick-embryo heart cells; it modulates the intracellular concentration of polyamines, and this appears to be closely related to histone acetylation.
D002455:Cell Division; D002478:Cells, Cultured; D004247:DNA / Q000378:metabolism; D005809:Genes, Regulator; D006657:Histones / Q000378:metabolism; D010101:Oxygen Consumption; D011073:Polyamines / Q000378:metabolism; D012313:RNA / Q000378:metabolism; D013936:Thymidine / Q000378:metabolism; D013997:Time Factors; D014158:Transcription, Genetic; D014529:Uridine / Q000378:metabolism
D006657:Histones; D011073:Polyamines; D012313:RNA; D004247:DNA; D013936:Thymidine; D014529:Uridine