Novel method for the determination of pediatric dosages.
A method by which safe and effective pediatric dosages can be estimated is presented. The method is based on the facts that drugs distribute into body water compartments and that these compartments are significantly different between pediatric and adult populations. The method discussed is tested using data reported in the literature.
D000367:Age Factors; D001830:Body Surface Area; D001834:Body Water; D001835:Body Weight; D005260:Female; D005839:Gentamicins / Q000008:administration & dosage; D006801:Humans; D007231:Infant, Newborn; D007234:Infant, Premature; D007612:Kanamycin / Q000008:administration & dosage; D008297:Male; D004364:Pharmaceutical Preparations / Q000008:administration & dosage* / Q000097:blood / Q000378:metabolism
D005839:Gentamicins; D004364:Pharmaceutical Preparations; D007612:Kanamycin