[The activities of aldehyde dehydrogenase, GABA-aminotransferase and succinic semialdehyde reductase in the brain of rats with different preferences and tolerances for ethanol].
The formation and catabolism of aldehydes were compared in the hemispheres and brain stem of rats preferring ethanol (EP) or water (WP) and of those which were high tolerant (HT) and low tolerant to the hypnotic effect of ethanol. It was shown that aldehyde dehydrogenase was more active in the brain stem of HT-EP rats than that of HT-WR or LT-EP animals, whereas GABA aminotransferase is most active in the hemispheres and brain stem of LT-EP rats. The total activity of succinic semialdehyde reductase was equal in all the groups studied; however kinetic analysis suggest that the enzyme has a higher affinity for the substrate and coenzyme in the brain stem of HT-EP rats. Ethanol administered to HT-EP animals suppressed aldehyde dehydrogenase in the brain stem, unchanged GABA aminotransferase and activates succinic semialdehyde reductase in the two brain structures.
Kanunnikova
N P
NP
Satanovskaia
V I
VI
D000612:4-Aminobutyrate Transaminase / Q000187:drug effects* / Q000378:metabolism; D000428:Alcohol Drinking / Q000378:metabolism*; D000444:Aldehyde Dehydrogenase / Q000187:drug effects* / Q000378:metabolism; D000818:Animals; D001921:Brain / Q000187:drug effects* / Q000201:enzymology; D001923:Brain Chemistry / Q000187:drug effects; D001933:Brain Stem / Q000187:drug effects / Q000201:enzymology; D004361:Drug Tolerance; D000431:Ethanol / Q000494:pharmacology*; D006884:Hydroxybutyrate Dehydrogenase / Q000187:drug effects* / Q000378:metabolism; D051381:Rats
D000431:Ethanol; D006884:Hydroxybutyrate Dehydrogenase; C019416:4-hydroxybutyrate dehydrogenase; D000444:Aldehyde Dehydrogenase; D000612:4-Aminobutyrate Transaminase
Aktivnost' al'degiddegidrogenazy, GAMK-aminotransferazy i reduktazy iantarnogo polual'degida v mozge krys s razlichnym otnosheniem k étanolu i tolerantnost'iu k nemu.