[Mechanism and effect of anisodamine on uteroplacental circulation in pregnancy-induced hypertension].
The short term effect of anisodamine, an alkaloid isolated from the chinese herb anisodas tonguticus, on blood flow of uterine and umbilical arteries in 16 pregnant women with pregnancy-induced hypertension (PIH) was investigated by means of pulsed doppler ultrasound technique Results have shown that anisodamine could decrease the A/B ratio, resistant index (RI), and pulsative index (PI) of blood velocity in these arteries with statistical significant difference. Its mechanism of action might be the improving of the rheology in PIH and adjusting the imbalance of TXA2/PGI2. It was suggested that the resistance in uteroplacental circulation was decreased and its perfusion improved, so that favors the fetal growth and development.
OuYang
W X
WX
Union Hospital, Tongji Medical University, Wuhan.
D015121:6-Ketoprostaglandin F1 alpha / Q000097:blood; D000328:Adult; D001809:Blood Viscosity / Q000187:drug effects; D005260:Female; D006801:Humans; D008833:Microcirculation / Q000187:drug effects; D010920:Placenta / Q000098:blood supply*; D011225:Pre-Eclampsia / Q000097:blood / Q000188:drug therapy* / Q000503:physiopathology; D011247:Pregnancy; D012039:Regional Blood Flow / Q000187:drug effects; D012991:Solanaceous Alkaloids / Q000627:therapeutic use*; D013929:Thromboxane B2 / Q000097:blood; D014469:Umbilical Arteries / Q000502:physiology*; D014599:Uterus / Q000098:blood supply*; D014655:Vascular Resistance / Q000187:drug effects
D012991:Solanaceous Alkaloids; C003922:anisodamine; D013929:Thromboxane B2; D015121:6-Ketoprostaglandin F1 alpha