Changes in urinary retinol binding protein excretion and other indices of renal tubular damage in patients with non-insulin dependent diabetes.
Changes in urine retinol binding protein (RBP, M(r) 21,000) excretion and other indices of renal tubular damage were investigated in the patients with non-insulin dependent diabetes mellitus (NIDDM). Changes in urine RBP excretion were well paralleled with those of urine NAG excretion. In RBP-negative patients, the subjects with hypertension (systolic blood pressure > or = 140 mmHg or diastolic blood pressure > or = 90 mmHg) showed higher beta 2-microglobulin (beta 2-MG) excretion and albumin (Alb)/Cr ratios than normotensive ones. In addition, both urine beta 2-MG excretions and Alb/Cr ratios were significantly increased in RBP-positive patients. The measurement of urine RBP excretion may have an additional role in the diagnosis of renal tubular dysfunction in diabetic patients.
Shimizu
H
H
First Department of Internal Medicine, Gunma University School of Medicine, Maebashi, Japan.
Negishi
M
M
Shimomura
Y
Y
Mori
M
M
D000118:Acetylglucosaminidase / Q000097:blood; D000419:Albuminuria; D015415:Biomarkers / Q000652:urine; D001794:Blood Pressure; D003924:Diabetes Mellitus, Type 2 / Q000503:physiopathology / Q000652:urine*; D003928:Diabetic Nephropathies / Q000175:diagnosis / Q000652:urine*; D005260:Female; D006801:Humans; D007684:Kidney Tubules / Q000473:pathology / Q000503:physiopathology*; D008297:Male; D008875:Middle Aged; D012177:Retinol-Binding Proteins / Q000652:urine*; D001613:beta 2-Microglobulin / Q000652:urine
D015415:Biomarkers; D012177:Retinol-Binding Proteins; D001613:beta 2-Microglobulin; D000118:Acetylglucosaminidase