title: [The results of the therapeutic monitoring of piracetam in parturients and newborn infants].
abstract: Overall 30 women in childbirth with preeclampsia and fetoplacental dysfunction received piracetam solution which was given initially in a dose of 5 g by intravenous drip, rapidly since the onset of labour and then every 2 hours till the end of labour in a dose of 2 g by jet injection. This made it possible to increase fetus resistance to hypoxic conditions. The concentrations of piracetam within the range of 60-80 g/l in the blood of women in childbirth should be viewed as minimum therapeutic. A single daily intramuscular injection of piracetam (50 mg/kg) into neonates with encephalopathies may build up blood concentrations equal to 25-60 mg/l after 2 hours. The drug is not detectable in the blood by the moment the next injection is given.
authors.forename: I V
authors.initials: IV
authors.lastname: Sirotina
authors.forename: Z D
authors.initials: ZD
authors.lastname: Aleksandrova
authors.forename: N V
authors.initials: NV
authors.lastname: Bogatyreva
authors.forename: V A
authors.initials: VA
authors.lastname: Gusel'
authors.forename: D P
authors.initials: DP
authors.lastname: Smirnov
authors.forename: D A
authors.initials: DA
authors.lastname: Khodov
authors.forename: O L
authors.initials: OL
authors.lastname: Grandilevskaia
mesh_terms: D000293:Adolescent; D000328:Adult; D001238:Asphyxia Neonatorum / Q000097:blood / Q000517:prevention & control; D002851:Chromatography, High Pressure Liquid; D002908:Chronic Disease; D016903:Drug Monitoring; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D007743:Labor, Obstetric / Q000097:blood / Q000187:drug effects*; D010889:Piracetam / Q000008:administration & dosage / Q000097:blood*; D010927:Placental Insufficiency / Q000097:blood / Q000188:drug therapy; D011225:Pre-Eclampsia / Q000097:blood / Q000188:drug therapy; D011247:Pregnancy
chemical_list: D010889:Piracetam
vernacular_title: Rezul'taty terapevticheskogo monitoringa piratsetama u rozhenits i novorozhdennykh deteĭ.