[Interleukin-1 production in patients with subacute and chronic opisthorchiasis].
Interleukin-1 (IL-1) production by peripheral blood lymphocytes was studied in 3 patients with the subacute and in 28 patients with the chronic stage of the disease. Monocyte culture was obtained by the H. R. Recalde method, IL-1 activity was evaluated by the S. B. Mizel modification of the classic LAF-ASSAY. In the subacute stage of the disease IL-1 activity was 3.3 fold lower that in healthy controls and lower than in the total group of patients with chronic opisthorchiasis (Kact. 0.64 +/- 0.09, 2.12 +/- 0.17, 1.83 +/- 0.11, respectively, p < 0.01, p < 0.01). In those with the syndrome of chronic gastroduodenitis IL-1 production was lower than in patients with the syndrome of cholepathy (Kact. 1.55 +/- 0.18 and 2.03 +/- 0.16, p < 0.01). Immediately after praziquantel therapy IL-1 production fell from Kact. 1.82 +/- 0.13 to 1.18 +/- 0.06 (p < 0.01), but 5-6 months later the production of the cytokine normalized in convalescents.
Martsiniuk
A Iu
AIu
Ozeretskovskaia
N N
NN
Lur'e
A A
AA
Koval'chuk
L V
LV
Osmolovskaia
S V
SV
D000208:Acute Disease; D000328:Adult; D002908:Chronic Disease; D005260:Female; D006801:Humans; D007375:Interleukin-1 / Q000096:biosynthesis* / Q000097:blood; D008297:Male; D009000:Monocytes / Q000378:metabolism; D009889:Opisthorchiasis / Q000097:blood* / Q000188:drug therapy; D011223:Praziquantel / Q000627:therapeutic use
D007375:Interleukin-1; D011223:Praziquantel
Produktsiia interleĭkina-1 u bol'nykh podostrym i khronicheskim opistorkhozom.