Cyclopentenyl ethylamines active on CNS.
Two new cyclopentenylethylamines were prepared and were submitted to a pharmacological screening together with some others previously described and now reprepared. All compounds exhibited different degrees of depressive activity on CNS and good analgesic activity. Compound 5, bearing a phenyl group on the carbon atom to which the amino group is connected, appears rather interesting being the most active as analgesic and the least toxic. Compounds 2 and 3 are able to antagonize in a certain degree lethal doses of physostigmine and also, respectively, of pentylenetetrazole and strychnine.
Mulè
A
A
Istituto di Tecnica Farmaceutica, Università di Sassari, Italia.
Pirisino
G
G
Moretti
M D
MD
Sparatore
F
F
Dimich
P M
PM
Satta
M
M
Peana
A
A
D000700:Analgesics / Q000494:pharmacology; D000818:Animals; D002491:Central Nervous System Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D005021:Ethylamines / Q000138:chemical synthesis* / Q000494:pharmacology; D005106:Exploratory Behavior / Q000187:drug effects; D005260:Female; D007928:Lethal Dose 50; D051379:Mice; D009125:Muscle Relaxants, Central / Q000494:pharmacology; D010433:Pentylenetetrazole / Q000037:antagonists & inhibitors; D010830:Physostigmine / Q000037:antagonists & inhibitors; D013331:Strychnine / Q000037:antagonists & inhibitors
D000700:Analgesics; D002491:Central Nervous System Agents; D005021:Ethylamines; D009125:Muscle Relaxants, Central; D010830:Physostigmine; D013331:Strychnine; D010433:Pentylenetetrazole