title: Increased calmodulin levels in fibroblasts from progressive systemic sclerosis.
abstract: Calmodulin levels in cultured skin fibroblasts from patients with progressive systemic sclerosis (PSS) and healthy controls were measured by their ability to activate cyclic AMP-phosphodiesterase. Calmodulin levels were significantly increased in PSS fibroblasts compared with normal control fibroblasts. The changes in calmodulin content of PSS fibroblasts were also assessed by a radioimmunoassay. These findings suggest that an elevated level of calmodulin may play a role in the pathogenesis of PSS.
authors.affiliation: Department of Dermatology, Gifu University School of Medicine, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Seishima
authors.forename: S
authors.initials: S
authors.lastname: Nagao
authors.forename: M
authors.initials: M
authors.lastname: Kuwahara
authors.forename: S
authors.initials: S
authors.lastname: Mori
authors.forename: Y
authors.initials: Y
authors.lastname: Nozawa
mesh_terms: D015105:3',5'-Cyclic-AMP Phosphodiesterases / Q000378:metabolism; D000328:Adult; D002118:Calcium / Q000378:metabolism; D002147:Calmodulin / Q000096:biosynthesis*; D002452:Cell Count; D002478:Cells, Cultured; D004789:Enzyme Activation; D005260:Female; D005347:Fibroblasts / Q000201:enzymology / Q000378:metabolism*; D006801:Humans; D008297:Male; D008875:Middle Aged; D012595:Scleroderma, Systemic / Q000201:enzymology / Q000378:metabolism*; D013997:Time Factors
chemical_list: D002147:Calmodulin; D015105:3',5'-Cyclic-AMP Phosphodiesterases; D002118:Calcium