Increased superoxide anion release by peritoneal macrophages in mice with a chronic infection of lactic dehydrogenase virus.
The function of macrophages in mice chronically infected by lactic dehydrogenase virus (LDV) was studied. Superoxide anion (O2-) release was examined by using peritoneal macrophages. O2- release increased markedly from 3 weeks to 12 months, but not at 1 week post infection. O2- release was 1.2 to 1.5 times greater than in uninfected mice. Increased O2- release from macrophages in LDV-infected mice may explain, at least in part, suppressive effects on tumour growth seen in the chronic phase of infection.
Hayashi
T
T
Laboratory of Veterinary Pathology, University of Yamaguchi, Japan.
Ozaki
M
M
Ami
Y
Y
Onodera
T
T
Yamamoto
H
H
D000818:Animals; D002908:Chronic Disease; D007772:Lactate dehydrogenase-elevating virus / Q000302:isolation & purification*; D008264:Macrophages / Q000378:metabolism* / Q000382:microbiology / Q000502:physiology; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D010529:Peritoneal Cavity / Q000166:cytology*; D013481:Superoxides / Q000378:metabolism*; D014777:Virus Diseases / Q000378:metabolism* / Q000503:physiopathology
D013481:Superoxides