[The effect of hypoxia and of subsequent baro-oxygenation on the function of the microsomal oxidation system in the rat liver].
The increase of cytochrome P-450 by 34% and its catalytic activity with substrate amidopyrine by 57% as compared with control has been shown under hypoxia (0.029 MPa, 1 h). Hyperoxia (0.2 MPa, 1 h) increases the metabolism of amidopyrine by 148%, benzo[a]pyrene by 158% and aniline by 114% and consecutive affection of hypoxia and hyperoxia--by 247, 45 and 138% correspondingly at fixed cytochrome P-450 amount in both series. The amount of diene conjugates and Schiff's bases under hypoxia increases by 40 and 69% correspondingly, the activity of SOD and catalase decreases by 25 and 23%. The activity of hyperoxia raises the diene conjugate content by 19% at all this SOD activity increases by 95%. Consecutive affection of hypoxia and hyperoxia increases the level of diene conjugates and Schiff's bases by 26 and 23% correspondingly, without changing SOD and catalase activity. The relative microsomal viscosity of lipid layer and zones of enzyme-lipid contacts decreased by 20 and 24% under hypoxia, but under hyperoxia and consecutive affection and hypoxia and hyperoxia it increases by 29-28% and 56-40% correspondingly.
Shchugaleĭ
V S
VS
Ananian
A A
AA
Miliutina
N P
NP
Sadekova
S I
SI
D000531:Altitude; D000818:Animals; D000975:Antioxidants; D001273:Atmosphere Exposure Chambers; D002462:Cell Membrane / Q000378:metabolism; D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism; D006931:Hyperbaric Oxygenation; D000860:Hypoxia / Q000378:metabolism*; D008051:Lipid Bilayers / Q000378:metabolism; D015227:Lipid Peroxidation; D008297:Male; D008862:Microsomes, Liver / Q000378:metabolism*; D010084:Oxidation-Reduction; D051381:Rats; D014783:Viscosity
D000975:Antioxidants; D008051:Lipid Bilayers; D003577:Cytochrome P-450 Enzyme System
Vliianie gipoksii i posleduiushcheĭ barooksigenatsii na sostoianie sistemy mikrosomal'nogo okisleniia v pecheni krys.