The effect of multi-glycosides of Tripterygium wilfordii Hook f. (GTW) on the survival time of cardiac allografts in rats.
Heterotopic heart transplantation was carried out in rats and the influence of multi-glycosides of Tripterygium wilfordii Hook f. (GTW) and a subtherapeutic dose of cyclosporine A (CsA) on the mean survival time (MST) of the cardiac allografts was investigated. The results showed that the MSTs of cardiac allografts in both the GTW and CsA-treated groups were significantly prolonged (P < 0.01 vs control). The rate of allograft rejection in the drug-treated groups was much lower than that in the control group.
Yang
X
X
PUMC Hospital, CAMS, Beijing.
Xu
L
L
Ren
H
H
Li
Z
Z
Sun
C
C
Zhang
Z
Z
D000005:Abdomen; D000818:Animals; D016572:Cyclosporine / Q000494:pharmacology; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D006027:Glycosides / Q000494:pharmacology; D006085:Graft Survival / Q000187:drug effects*; D016027:Heart Transplantation; D007166:Immunosuppressive Agents / Q000494:pharmacology*; D051381:Rats; D011916:Rats, Inbred F344; D011919:Rats, Inbred Strains; D016042:Transplantation, Heterotopic; D029757:Tripterygium
D004365:Drugs, Chinese Herbal; D006027:Glycosides; D007166:Immunosuppressive Agents; D016572:Cyclosporine