Pharmacokinetics of cefaclor AF: effects of age, antacids and H2-receptor antagonists.
The pharmacokinetics and bioavailability of cefaclor advanced formulation (cefaclor AF) were investigated in two studies, one comparing healthy elderly and younger volunteers and the other assessing the effects of an antacid and H2-receptor antagonist on cefaclor AF bioavailability. The pharmacokinetics of a 750 mg dose of cefaclor AF were studied in 30 subjects ranging in age from 65 to 84 years and 10 control subjects 21-45 years of age. Compared with controls, elderly subjects exhibited higher plasma concentrations of cefaclor which were attributed to lower plasma clearance. There was a strong association between age and renal function, and the plasma clearance of cefaclor was highly dependent upon renal function. Thus, elderly patients with impaired renal function had a reduced ability to eliminate cefaclor. Due to a short elimination half-life and wide therapeutic index, dosage adjustments are not necessary in patients exhibiting moderate renal dysfunction. The 15 healthy men in the second trial were crossed over to receive five treatments, including cefaclor AF (500 mg) alone, cefaclor AF with or preceded by cimetidine, cefaclor AF followed by Maalox TC and cefaclor immediate release (500 mg) alone. Cefaclor AF and immediate release cefaclor had similar bioavailability, but plasma concentrations were maintained for a longer period of time when cefaclor AF was administered. Cimetidine did not alter the bioavailability of cefaclor AF but Maalox TC, coadministered with cefaclor AF, reduced the extent of absorption. This suggests that cefaclor AF bioavailability is influenced by the antacid Maalox TC but not by H2-receptor antagonist cimetidine.
Satterwhite
J H
JH
Lilly Research Laboratories, Wishard Memorial Hospital, Indianapolis, Indiana 46202.
Cerimele
B J
BJ
Coleman
D L
DL
Hatcher
B L
BL
Kisicki
J
J
DeSante
K A
KA
D000328:Adult; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D000536:Aluminum Hydroxide / Q000494:pharmacology; D000863:Antacids / Q000494:pharmacology; D001682:Biological Availability; D002433:Cefaclor / Q000097:blood / Q000493:pharmacokinetics*; D002626:Chemistry, Pharmaceutical; D002927:Cimetidine / Q000494:pharmacology; D004338:Drug Combinations; D006801:Humans; D007408:Intestinal Absorption / Q000187:drug effects; D008276:Magnesium Hydroxide / Q000494:pharmacology; D008297:Male; D008875:Middle Aged; D013997:Time Factors
D000863:Antacids; D004338:Drug Combinations; C013591:aluminum hydroxide, magnesium hydroxide, drug combination; D000536:Aluminum Hydroxide; D002433:Cefaclor; D002927:Cimetidine; D008276:Magnesium Hydroxide