Melanocyte-stimulating properties of arachidonic acid metabolites: possible role in postinflammatory pigmentation.
Normal human epidermal melanocytes became swollen and more dendritic with an increase in the amount of tyrosinase and immunoreactive b-locus protein when they were cultured for 2 days with the following arachidonic acid metabolites: prostaglandin (PG) D2, leukotriene (LT) B4, LTC4, LTD4, LTE4, thromboxane (TX) B2 and 12-hydroxy eicosatetraenoic acid (12-HETE). The effect of LTC4 was particularly strong compared to that of PGE2, about which we have previously reported. On the other hand, PGE1, PGF2 alpha and 6-ketoPGF1 alpha did not show any significant stimulatory effect. These data suggest that arachidonate-derived chemical mediators, especially LTC4, may be responsible for the induction of post-inflammatory hyperpigmentation of the skin.
Tomita
Y
Y
Department of Dermatology, Tohoku University School of Medicine, Sendai, Japan.
Maeda
K
K
Tagami
H
H
D019377:12-Hydroxy-5,8,10,14-eicosatetraenoic Acid; D000328:Adult; D001095:Arachidonic Acids / Q000378:metabolism*; D002455:Cell Division / Q000502:physiology; D016222:Fibroblast Growth Factor 2 / Q000494:pharmacology; D005455:Fluorescent Antibody Technique; D006801:Humans; D006893:Hydroxyeicosatetraenoic Acids / Q000494:pharmacology; D007249:Inflammation / Q000503:physiopathology; D015289:Leukotrienes / Q000494:pharmacology; D008297:Male; D008544:Melanocytes / Q000166:cytology / Q000201:enzymology / Q000502:physiology*; D014442:Monophenol Monooxygenase / Q000378:metabolism / Q000502:physiology; D015230:Prostaglandin D2 / Q000494:pharmacology; D012880:Skin Pigmentation / Q000187:drug effects / Q000502:physiology*; D013929:Thromboxane B2 / Q000494:pharmacology
D001095:Arachidonic Acids; D006893:Hydroxyeicosatetraenoic Acids; D015289:Leukotrienes; D016222:Fibroblast Growth Factor 2; D013929:Thromboxane B2; D019377:12-Hydroxy-5,8,10,14-eicosatetraenoic Acid; D014442:Monophenol Monooxygenase; D015230:Prostaglandin D2