title: [Primary prevention trial. Methodological problems].
abstract: Primary prevention trials are the best method of demonstrating the true value of medical intervention to correct abnormalities of lipid metabolism. A large number of patients must be followed up for a long period and this explains the complexity of the logistic problems which are encountered. However, these trials must conform to the classical guide lines of all clinical trials: an accurate definition of the study population, a principal criterion of adjustment which satisfies the golden rule "One question, one study".
authors.forename: A
authors.initials: A
authors.lastname: Munoz
mesh_terms: D002986:Clinical Trials as Topic / Q000379:methods*; D006801:Humans; D006949:Hyperlipidemias / Q000150:complications / Q000188:drug therapy*; D016015:Logistic Models; D017202:Myocardial Ischemia / Q000209:etiology / Q000401:mortality; D011322:Primary Prevention; D012306:Risk
vernacular_title: L'essai de prévention primaire. Problèmes méthodologiques.