Localization of PMP-22 gene (candidate gene for the Charcot-Marie-Tooth disease 1A) to band 17p11.2 by direct R-banding fluorescence in situ hybridization.
We mapped PMP-22 gene, candidate gene for the Charcot-Marie-Tooth disease (CMT) 1A, by direct R-banding fluorescence in situ hybridization. The signals of PMP-22 probe were localized to chromosome band 17p11.2. The present result was within the map position of the CMT 1A gene by genetic linkage analysis, and strongly indicated that PMP-22 gene is a candidate gene for the CMT 1A.
Takahashi
E
E
Division of Genetics, National Institute of Radiological Science, Chiba, Japan.
Takeda
O
O
Himoro
M
M
Nanao
K
K
Takada
G
G
Hayasaka
K
K
D002607:Charcot-Marie-Tooth Disease / Q000235:genetics*; D002871:Chromosome Banding / Q000379:methods; D002874:Chromosome Mapping / Q000379:methods; D002886:Chromosomes, Human, Pair 17; D005796:Genes; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D009185:Myelin Proteins / Q000235:genetics*
D009185:Myelin Proteins; C073687:PMP22 protein, human