title: Effect of three months treatment with Ukrain on peripheral blood morphology in rodents.
abstract: Studies on Albino Swiss mice and Wistar rats have demonstrated that Ukrain administered intraperitoneally (i.p.) for three months produces the following effects in the haematologic parameters: increased leucocytes and decreased thrombocytes. The haemoglobin and erythrocyte levels, as well as haematocrit value, were unchanged. In the leucogram changes were observed; i.e., a fall in the number of neutrophil segments and an increase in the lymphocyte count. The erythrocyte indices, P.C.V., M.C.V., M.C.H. and M.C.H.C. were not changed by a period of three months i.p. Ukrain administration. The observed changes were more marked in female than in male animals and were greater in mice than in rats.
authors.affiliation: Department of Pharmacology, Medical Academy, Lublin, Poland.
authors.forename: E
authors.initials: E
authors.lastname: Jagiełło-Wójtowicz
authors.forename: Z
authors.initials: Z
authors.lastname: Kleinrok
authors.forename: B
authors.initials: B
authors.lastname: Matuszek
authors.forename: B
authors.initials: B
authors.lastname: Surmaczyńska
authors.forename: E
authors.initials: E
authors.lastname: Baran
authors.forename: W
authors.initials: W
authors.lastname: Nowicky
authors.forename: J W
authors.initials: JW
authors.lastname: Nowicky
mesh_terms: D000470:Alkaloids / Q000097:blood*; D000818:Animals; D001600:Berberine Alkaloids; D004906:Erythrocyte Count / Q000187:drug effects; D005260:Female; D006400:Hematocrit; D006454:Hemoglobins / Q000378:metabolism; D007958:Leukocyte Count / Q000187:drug effects; D008214:Lymphocytes / Q000187:drug effects; D008297:Male; D051379:Mice; D010617:Phenanthridines; D010976:Platelet Count / Q000187:drug effects; D051381:Rats; D017208:Rats, Wistar; D012727:Sex Characteristics; D013045:Species Specificity
chemical_list: D000470:Alkaloids; D001600:Berberine Alkaloids; D006454:Hemoglobins; D010617:Phenanthridines; C060921:ukrain