title: Synthesis and interaction studies of watersoluble nucleic acid analogs containing serine as a spacer.
abstract: Watersoluble nucleic acid analogs containing L- or D-serine as a spacer were synthesized. Thymine was used as nucleic acid bases of these analogs. The base contents of these analogs were 93-94%. These analogs were found to form stable polymer complexes with Poly A or DNA by specific base-base interaction, which were observed from hypochromicity of UV spectra. In both cases, the maximum hypochromicity values of PEI-L-Ser-Thy were higher than that of PEI-D-Ser-Thy.
authors.affiliation: Faculty of Engineering, Osaka University, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Wada
authors.forename: N
authors.initials: N
authors.lastname: Masumi
authors.forename: E
authors.initials: E
authors.lastname: Mochizuki
authors.forename: Y
authors.initials: Y
authors.lastname: Inaki
authors.forename: K
authors.initials: K
authors.lastname: Takemoto
mesh_terms: D002942:Circular Dichroism; D004247:DNA / Q000737:chemistry; D015394:Molecular Structure; D009696:Nucleic Acids / Q000138:chemical synthesis*; D011061:Poly A / Q000737:chemistry; D012694:Serine / Q000737:chemistry*; D012995:Solubility; D014867:Water
chemical_list: D009696:Nucleic Acids; D014867:Water; D011061:Poly A; D012694:Serine; D004247:DNA