[The effect of polymeric modification on the biological activity of pancreatic ribonuclease].
The effect of modification of dextran on pharmacokinetic properties of pancreatic RNAse and on its ability to suppress the proliferation of cells has been studied. It has been shown that the basic contribution to biological activity of polymer form of RNAse is making by azo-bonds which are forming in the process of chemical bonding of the protein with dextran support.
Kalacheva
N V
NV
Kupriianov-Ashin
E G
EG
Kurpinenko
B M
BM
D000818:Animals; D002455:Cell Division / Q000187:drug effects; D002460:Cell Line; D002478:Cells, Cultured / Q000166:cytology / Q000187:drug effects; D003911:Dextrans / Q000494:pharmacology; D006801:Humans; D046911:Macromolecular Substances; D010179:Pancreas / Q000201:enzymology*; D011485:Protein Binding / Q000187:drug effects; D011817:Rabbits; D012260:Ribonucleases / Q000187:drug effects* / Q000493:pharmacokinetics
D003911:Dextrans; D046911:Macromolecular Substances; D012260:Ribonucleases
Vliianie polimernoĭ modifikatsii na biologicheskuiu aktivnost' pankreaticheskoĭ ribonukleazy.