title: Furan and thiophene analogues of omeprazole.
abstract: Synthesis and structure of some analogs of the omeprazole containing furan and thiophene rings are reported. Their effects on the basal and the histamine-stimulated secretion were evaluated on the isolated rat stomach.
authors.affiliation: Dipartimento di Scienza e Tecnologia del Farmaco, Torino, Italy.
authors.forename: G
authors.initials: G
authors.lastname: Sorba
authors.forename: A
authors.initials: A
authors.lastname: Di Stilo
authors.forename: M
authors.initials: M
authors.lastname: Gili
authors.forename: A
authors.initials: A
authors.lastname: Gasco
authors.forename: G
authors.initials: G
authors.lastname: Bertaccini
authors.forename: M
authors.initials: M
authors.lastname: Adami
authors.forename: G
authors.initials: G
authors.lastname: Coruzzi
mesh_terms: D000818:Animals; D000897:Anti-Ulcer Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D005663:Furans / Q000138:chemical synthesis* / Q000494:pharmacology; D005744:Gastric Acid / Q000378:metabolism; D066298:In Vitro Techniques; D008297:Male; D009853:Omeprazole / Q000031:analogs & derivatives* / Q000138:chemical synthesis; D051381:Rats; D013876:Thiophenes / Q000138:chemical synthesis* / Q000494:pharmacology
chemical_list: D000897:Anti-Ulcer Agents; D005663:Furans; D013876:Thiophenes; D009853:Omeprazole