[A method for the primary biological assessment of the photodynamic activity of photosensitizers in a nontumor model in vivo].
In comparison with traditional laboratory methods of photosensitizers screening in vitro and in vivo on transplanted tumors, the proposed method of PDA evaluation has the advantages. Criterion of PDA is the quantitative characteristic--the area of photodynamic necrosis on the surface of laboratory mice liver 24 hours after combined action. According to the screening results, PDA of photosensitizers is distributed: AIPcS2-3 > AIPcS1 > Photofrin-2 > AIPcS3 > or = HpDChina > Fotosan-3 > Fotosan-2. Morphological research allows to characterize PDA of photosensitizers qualitatively. Thus, AIPcSx derivatives have more expressed cytolytic and nucleotropic effect on parenchyma cells (hepatocytes) in comparison with HpD derivatives.
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Raĭkhlin
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D000818:Animals; D004195:Disease Models, Animal; D004354:Drug Screening Assays, Antitumor / Q000379:methods; D007834:Lasers; D008099:Liver / Q000187:drug effects / Q000528:radiation effects / Q000648:ultrastructure; D008297:Male; D051379:Mice; D009336:Necrosis; D009368:Neoplasm Transplantation; D009374:Neoplasms, Experimental / Q000188:drug therapy / Q000648:ultrastructure; D010778:Photochemotherapy / Q000379:methods*; D017319:Photosensitizing Agents / Q000627:therapeutic use*
D017319:Photosensitizing Agents
Sposob pervichnoĭ biologicherskoĭ otsenki fotodinamicheskoĭ aktivnosti fotosensibilizatorov na neopukholevoĭ modeli in vivo.