[Protective effect of dextromethorphan on the ischemic retinal damage in rabbit].
To investigate the effect of dextromethorphan (DEX), N-methyl-D-aspartate (NMDA) receptor antagonist, on the retinal ischemia, 0.4%DEX hydrobromide was intravenously given to rabbits before, during and after retinal ischemia. Retinal function was monitored by electroretinogram (ERG). Retinal ischemia was induced by increasing intraocular pressure to 130 mmHg for 90 or 120 min. Amplitudes of ERG.b-waves recorded after the 90 min ischemia recovered to 72.5 +/- 9.0% in the DEX group and 38.5 +/- 8.5% in the control group which was given normal saline. The maximal recovery rates of b-wave amplitudes after the 120 min ischemia were 44.0 +/- 7.9% in the DEX group and 21.0 +/- 1.3% in the control group. The recovery rates of the b-wave amplitudes in DEX group were significantly higher than in the control group (p less than 0.01). It was found that the effective dose of DEX was 0.1-0.4%.
Sugawara
T
T
Department of Ophthalmology, Iwate Medical University, Morioka, Japan.
Mori
T
T
Kamei
S
S
Tazawa
Y
Y
D000818:Animals; D003915:Dextromethorphan / Q000627:therapeutic use*; D004596:Electroretinography; D007511:Ischemia / Q000503:physiopathology / Q000517:prevention & control*; D011817:Rabbits; D017470:Receptors, Glutamate; D017981:Receptors, Neurotransmitter / Q000037:antagonists & inhibitors; D012160:Retina / Q000503:physiopathology; D012171:Retinal Vessels
D017470:Receptors, Glutamate; D017981:Receptors, Neurotransmitter; D003915:Dextromethorphan