[Experimental studies of lung lesions in rabbits caused by Streptomyces thermohygroscopicus].
Imitating the natural way of infection of Farmer's lung disease, we succeeded in inducing acute lesions of Farmer's lung disease in rabbits by the dry powder of thermohygroscopicus. Histopathological examination revealed typical interstitial pneumonitis, alveolitis and bronchiolitis. One week after the inhalation of the dry powder of thermohygroscopicus, the precipitins could be detected in the rabbits' serum by immunoblotting. Depending on the lung lesions of rabbits, we discussed the pathogenetic mechanisms of Farmer's Lung.
Liu
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Department of Microbiology, Hubei Medical College Xianning Branch.
D000818:Animals; D004195:Disease Models, Animal; D005203:Farmer's Lung / Q000276:immunology / Q000382:microbiology / Q000473:pathology*; D016908:Gram-Positive Bacterial Infections; D008168:Lung / Q000473:pathology; D011234:Precipitins / Q000097:blood; D011817:Rabbits; D013302:Streptomyces
D011234:Precipitins