Evidence for insulin dependent hepatic microsomal gamma-linolenic acid chain elongation in spontaneously diabetic Wistar BB rats.
We studied hepatic microsomal gamma-linolenoyl-CoA elongation and fatty acid composition of liver microsomes in spontaneously diabetic Wistar BB rats. The liver microsomal gamma-linolenoyl-CoA elongation was decreased in diabetic Wistar BB rats during both normo- and hyperglycemic periods and restored during the hypoglycemic period following insulin treatment. These results are in agreement with our previously reported data on linoleic acid delta 6 and delta 5 desaturations and support the non-parallel relationship between the chain elongation system and the glycemia. The fatty acid composition of BB rat liver microsomes was only partially consistent with the gamma-linolenoyl-CoA elongation activity at the different periods of glycemia, probably because factors other than elongation impairments were involved in the evolution of fatty acid composition.
Mimouni
V
V
Unité de Recherches de Nutrition Cellulaire et Métabolique, Université de Bourgogne, Faculté des Sciences Mirande, Dijon, France.
Narce
M
M
Poisson
J P
JP
D000214:Acyl Coenzyme A / Q000378:metabolism; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000378:metabolism; D001786:Blood Glucose / Q000378:metabolism; D003922:Diabetes Mellitus, Type 1 / Q000097:blood / Q000378:metabolism*; D004042:Dietary Fats, Unsaturated / Q000378:metabolism; D007328:Insulin / Q000494:pharmacology*; D008042:Linolenic Acids / Q000378:metabolism*; D008297:Male; D051379:Mice; D008862:Microsomes, Liver / Q000187:drug effects / Q000378:metabolism*; D051381:Rats; D011913:Rats, Inbred BB; D014280:Triglycerides / Q000097:blood; D017965:gamma-Linolenic Acid
D000214:Acyl Coenzyme A; D000894:Anti-Inflammatory Agents, Non-Steroidal; D001786:Blood Glucose; D004042:Dietary Fats, Unsaturated; D007328:Insulin; D008042:Linolenic Acids; D014280:Triglycerides; C026562:linoleoyl-coenzyme A; D017965:gamma-Linolenic Acid