[The participation of prostanoids in the realization of the cardioprotective, antistressor and anti-arrhythmic effects of enkephalins].
It has been established that preliminary administration of D-Ala2-Leu5-Arg6-enkephalin, D-Met2-Pro5-enkephalinamide, and D-phenylalanine to experimental animals prevents a stress-induced increase of the content of thromboxane in the blood plasma and myocardium and induces a rise of the level of prostacyclin, PGF2 and PGE in the heart and blood plasma. The authors hold that the changes in the level of prostanoids may mediate cardioprotective and anti-stressor rather than antiarrhythmic effects of enkephalins.
Lishmanov
Iu B
IuB
Maslov
L N
LN
Rebrova
T Iu
TIu
Fedotova
T V
TV
D000818:Animals; D000889:Anti-Arrhythmia Agents / Q000627:therapeutic use*; D004195:Disease Models, Animal; D004353:Drug Evaluation, Preclinical; D016308:Enkephalin, Leucine-2-Alanine / Q000031:analogs & derivatives* / Q000627:therapeutic use; D004744:Enkephalin, Methionine / Q000031:analogs & derivatives* / Q000627:therapeutic use; D006321:Heart / Q000187:drug effects*; D017202:Myocardial Ischemia / Q000188:drug therapy / Q000378:metabolism; D009206:Myocardium / Q000378:metabolism; D011453:Prostaglandins / Q000502:physiology*; D013312:Stress, Physiological / Q000188:drug therapy* / Q000378:metabolism; D014693:Ventricular Fibrillation / Q000188:drug therapy / Q000378:metabolism
D000889:Anti-Arrhythmia Agents; D011453:Prostaglandins; D004744:Enkephalin, Methionine; C021717:enkephalin, Met(2)-ProNH2(5)-; D016308:Enkephalin, Leucine-2-Alanine; C040996:enkephalin-Leu, Ala(2)-Arg(6)-
Uchastie prostanoidov v realizatsii kardioprotektornykh, antistressornykh i antiaritmicheskikh éffektov énkefalinov.