Synthesis and local anesthetic and circulatory actions of aminoesters and hydroxyamine monoterpene derivatives.
Esters of N,N-diethylaminoacetic acid and hydroxyamines, obtained from structurally different natural monoterpenes, were pharmacologically examined. It was proved that salts of the obtained compounds had local anesthetic properties in infiltration anesthesia, compounds 9, 6 and 8 having been more potent than lidocaine. Compounds 7-9 slightly increased the arrhythmogenic dose, and compound 12 - the lethal dose of strophanthin. All the examined compounds transiently decreased the arterial blood pressure and displayed a cardiopressive activity.
Siemieniuk
A
A
Institute of Organic and Physical Chemistry, Technical University, Wrocław, Poland.
Szałkowska-Pagowska
H
H
Lochyński
S
S
Piatkowski
K
K
Filipek
B
B
Krupińska
J
J
Czarnecki
R
R
Librowski
T
T
Zebala
K
K
D000779:Anesthetics, Local / Q000138:chemical synthesis* / Q000494:pharmacology / Q000633:toxicity; D000818:Animals; D000889:Anti-Arrhythmia Agents / Q000138:chemical synthesis / Q000494:pharmacology / Q000633:toxicity; D001145:Arrhythmias, Cardiac / Q000139:chemically induced / Q000517:prevention & control; D001794:Blood Pressure / Q000187:drug effects; D002317:Cardiovascular Agents / Q000138:chemical synthesis* / Q000494:pharmacology / Q000633:toxicity; D002849:Chromatography, Gas; D002855:Chromatography, Thin Layer; D006168:Guinea Pigs; D006321:Heart / Q000187:drug effects; D006898:Hydroxylamines / Q000138:chemical synthesis* / Q000494:pharmacology / Q000633:toxicity; D066298:In Vitro Techniques; D007928:Lethal Dose 50; D008297:Male; D051379:Mice; D051381:Rats; D017208:Rats, Wistar; D013729:Terpenes / Q000138:chemical synthesis* / Q000494:pharmacology / Q000633:toxicity
D000779:Anesthetics, Local; D000889:Anti-Arrhythmia Agents; D002317:Cardiovascular Agents; D006898:Hydroxylamines; D013729:Terpenes