title: Decreased uptake of low density lipoprotein by LLC-PK cells cultured at low magnesium concentration.
abstract: LLC-PK cells grown in tissue culture on medium containing normal or deficient amounts of magnesium were presented with 125I-low density lipoprotein (LDL) and the uptake determined. Total LDL uptake by Mg-deficient cells decreased as the magnesium concentration decreased. The receptor binding of LDL and the internalization of LDL by the Mg-deficient cells were reduced. Degradation of LDL by Mg-deficient cells, when corrected for the reduced uptake, was less affected.
authors.affiliation: Burnsides Research Laboratory, University of Illinois, Urbana.
authors.forename: M M
authors.initials: MM
authors.lastname: Mahfouz
authors.forename: T L
authors.initials: TL
authors.lastname: Smith
authors.forename: F A
authors.initials: FA
authors.lastname: Kummerow
mesh_terms: D000818:Animals; D002460:Cell Line; D006801:Humans; D007457:Iodine Radioisotopes; D008077:Lipoproteins, LDL / Q000378:metabolism*; D008275:Magnesium Deficiency / Q000378:metabolism*; D013499:Surface Properties; D013552:Swine
chemical_list: D007457:Iodine Radioisotopes; D008077:Lipoproteins, LDL