The control of cholesterol metabolism and plasma lipid levels in infant rats.
Infant rats received an i.p. injection of insulin, anti-insulin serum, streptozotocin, antiglucagon serum or dexamethasone. All substances except the antiinsulin serum, raised the plasma triglyceride level. Both antisera decreased plasma cholesterol levels, while streptozotocin, insulin and dexamethasone caused an increase. The activity of 3-hydroxy-3-glutaryl CoA reductase in liver and brown adipose tissue changed inversely to the cholesterol level. However, small intestinal enzyme activity was increased by insulin administration inspite of the rise in plasma cholesterol.
Hahn
P
P
Department of Obstetrics and Gynaecology, University of British Columbia, Vancouver, Canada.
Mahler
L
L
D000273:Adipose Tissue / Q000201:enzymology; D000818:Animals; D000831:Animals, Newborn / Q000097:blood / Q000378:metabolism*; D000906:Antibodies / Q000008:administration & dosage / Q000276:immunology / Q000494:pharmacology; D002784:Cholesterol / Q000097:blood / Q000378:metabolism*; D003907:Dexamethasone / Q000008:administration & dosage / Q000494:pharmacology; D005934:Glucagon / Q000276:immunology / Q000502:physiology; D006903:Hydroxymethylglutaryl CoA Reductases / Q000032:analysis; D007274:Injections, Intraperitoneal; D007328:Insulin / Q000008:administration & dosage / Q000276:immunology / Q000502:physiology; D007659:Ketones / Q000378:metabolism; D008055:Lipids / Q000097:blood*; D008099:Liver / Q000201:enzymology; D051381:Rats; D017208:Rats, Wistar; D013311:Streptozocin / Q000008:administration & dosage / Q000494:pharmacology; D014280:Triglycerides / Q000097:blood
D000906:Antibodies; D007328:Insulin; D007659:Ketones; D008055:Lipids; D014280:Triglycerides; D013311:Streptozocin; D003907:Dexamethasone; D005934:Glucagon; D002784:Cholesterol; D006903:Hydroxymethylglutaryl CoA Reductases