title: Increased rate of survival in Streptococcus pneumoniae-infected rats treated with the new immunomodulator Pidotimod.
abstract: Wistar rats infected with Streptococcus pneumoniae (type III ATCC) rapidly develop an acute form of experimental lobar pneumonia (ELP) with death of 80-90% of the animals by 6 days after the infection. Prophylactic treatment of these animals with the novel immunomodulator Pidotimod, at the dose of 25 mg/kg bw, significantly increased their rate of survival as compared to the control group (50 vs. 90% respectively). Recovery from the infection appeared definitive since all the Pidotimod-treated survivors were alive and in good condition at the end of the observation period (45 days post infection). Prophylactic treatment with higher or lower doses of the drug was ineffective. Therapy with Pidotimod was not effective. This preliminary study suggests that Pidotimod may have contributed to activation of specific and non-specific immune effectors involved in the host response to S. pneumoniae infection.
authors.affiliation: Department of Medical Pathology and Metabolic Diseases, University of Catania, Italy.
authors.forename: R
authors.initials: R
authors.lastname: di Marco
authors.forename: F
authors.initials: F
authors.lastname: Condorelli
authors.forename: R
authors.initials: R
authors.lastname: Girardello
authors.forename: C
authors.initials: C
authors.lastname: Uslenghi
authors.forename: G
authors.initials: G
authors.lastname: Chisari
authors.forename: M
authors.initials: M
authors.lastname: di Mauro
authors.forename: A M
authors.initials: AM
authors.lastname: Speciale
authors.forename: P L
authors.initials: PL
authors.lastname: Meroni
authors.forename: F
authors.initials: F
authors.lastname: Nicoletti
mesh_terms: D000276:Adjuvants, Immunologic / Q000627:therapeutic use*; D000818:Animals; D008297:Male; D011018:Pneumonia, Pneumococcal / Q000401:mortality / Q000628:therapy*; D011761:Pyrrolidonecarboxylic Acid / Q000031:analogs & derivatives* / Q000627:therapeutic use; D051381:Rats; D017208:Rats, Wistar; D013844:Thiazoles / Q000627:therapeutic use*; D053778:Thiazolidines
chemical_list: D000276:Adjuvants, Immunologic; D013844:Thiazoles; D053778:Thiazolidines; C064893:pidotimod; D011761:Pyrrolidonecarboxylic Acid