title: [Nisoldipine in comparison with long-term nitrates].
abstract: Nisoldipine represents a new attractive second generation calcium channel blocker of the dihydropyridine-class for the treatment of all types of coronary artery disease. The effect on chronic ischemia is comparable to long-acting nitrates, side-effects have been rarely observed. The advantages will be the high vascular selectivity with only slight negative inotropic effect as well as a long-lasting positive influence on the myocardial metabolism. Up to now, no studies have been reported which compare nisoldipine and long-acting nitrates directly, but this calcium antagonist appears to influence duration and intensity of symptomatic and silent episodes of ischemia similar to the nitrates.
authors.affiliation: Medizinischen Universitätsklinik Graz.
authors.forename: B
authors.initials: B
authors.lastname: Eber
authors.forename: M
authors.initials: M
authors.lastname: Schumacher
authors.forename: R
authors.initials: R
authors.lastname: Zweiker
authors.forename: R
authors.initials: R
authors.lastname: Pokan
authors.forename: W
authors.initials: W
authors.lastname: Klein
mesh_terms: D000787:Angina Pectoris / Q000188:drug therapy; D000818:Animals; D003326:Coronary Circulation / Q000187:drug effects; D003327:Coronary Disease / Q000188:drug therapy*; D003329:Coronary Vasospasm / Q000188:drug therapy; D006801:Humans; D017202:Myocardial Ischemia / Q000188:drug therapy*; D015737:Nisoldipine / Q000627:therapeutic use*; D009566:Nitrates / Q000627:therapeutic use*
chemical_list: D009566:Nitrates; D015737:Nisoldipine
vernacular_title: Nisoldipin im Vergleich zu Langzeitnitraten.