title: Seroepidemiological study of the circulation of influenza C virus in man.
abstract: The seroepidemiological study of the circulation of influenza C virus was achieved by testing HI antibodies in human sera collected from healthy subjects in Bucharest belonging to various age groups. The investigations were carried out over a two years period (October 1988--September 1990), using 3 influenza C virus strains: C/Taylor/1233/47, C/USSR/0303/77 and C/Moscow/1/84, the last two being antigenically similar. The analysis of the distribution of HI antibody values against the three influenza C virus strains showed that over October 1988--June 1989 the reported circulating viruses belonged to two distinct antigenic groups, one similar to the prototype C/Taylor/47 strains and the other to C/USSR/and/C/Moscow strains, whilst during the July 1989--September 1990 time interval viruses belonging solely to the C/USSR and C/Moscow antigenic group circulated. Similarly, one should note that circulation of influenza C viruses is not seasonal, it can appear anytime and even several times per year; this accounts for the relatively high and permanent antibody level in the population belonging to all age groups.
authors.affiliation: Cantacuzino Institute, Bucharest, Romania.
authors.forename: E
authors.initials: E
authors.lastname: Ioniţă
authors.forename: E
authors.initials: E
authors.lastname: Lupulescu
authors.forename: V
authors.initials: V
authors.lastname: Alexandrescu
authors.forename: M
authors.initials: M
authors.lastname: Maţepiuc
authors.forename: C
authors.initials: C
authors.lastname: Tecu
mesh_terms: D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000914:Antibodies, Viral / Q000097:blood; D002648:Child; D002675:Child, Preschool; D006385:Hemagglutination Inhibition Tests; D006801:Humans; D007223:Infant; D007251:Influenza, Human / Q000453:epidemiology* / Q000276:immunology; D009982:Gammainfluenzavirus / Q000276:immunology; D008875:Middle Aged; D015995:Prevalence; D012383:Romania / Q000453:epidemiology; D016036:Seroepidemiologic Studies; D014505:Urban Population / Q000706:statistics & numerical data
chemical_list: D000914:Antibodies, Viral