[New approaches to developing drugs with cartilage protective properties].
The conjuncture and technological analysis was made of the current status and approaches to further development of the drugs--chondroprotectors on the basis of glycosaminoglycans. The concept of the goal-oriented search of the new type of drugs for the treatment of diseases of joints and other pathologies was worded on the basis of the systematization and summarization of the reported data and the results of own investigations. This concept rests on the current views of biochemistry of the nature of metabolism and the mechanisms of its regulation. The approach suggested lies in obtaining specific products--protein fragments (polypeptides) that contain oxidized functional groups not found, as a rule, under natural conditions in normal physiological state. The conversion of protein fragments to a higher degree of oxidation means the conversion to the metabolic state in which the possibility of regulating disturbed metabolism is provided. In order to realize the given approach, it is proposed that the oxidation-hydrolytic modification of human placenta may be performed with the aid of chlorine dioxide or direct synthesis. The results of studying the physicochemical and pharmacological properties of the products obtained are presented. Animal experiments have demonstrated a powerful hitherto unknown pharmacotherapeutic action in a dose of 0.3 mg/kg, namely chondroprotective, resolving, reparative, antiinflammatory, antioxidant, analgesic, antistress, and immunotropic. The regulatory mechanism of the action of the substances obtained is suggested.
Shitov
G G
GG
D000255:Adenosine Triphosphate / Q000378:metabolism; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use*; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000627:therapeutic use; D002356:Cartilage / Q000187:drug effects* / Q000378:metabolism; D002809:Chondroitin Sulfates / Q000627:therapeutic use; D003094:Collagen / Q000378:metabolism; D003871:Dermatan Sulfate / Q000627:therapeutic use; D006025:Glycosaminoglycans / Q000627:therapeutic use; D006801:Humans; D007592:Joint Diseases / Q000188:drug therapy* / Q000378:metabolism; D051381:Rats; D014020:Tissue Extracts / Q000627:therapeutic use
D000893:Anti-Inflammatory Agents; D000894:Anti-Inflammatory Agents, Non-Steroidal; D006025:Glycosaminoglycans; D014020:Tissue Extracts; C000562:Rumalon; D003871:Dermatan Sulfate; C010034:Arteparon; D000255:Adenosine Triphosphate; D002809:Chondroitin Sulfates; D003094:Collagen
Novye podkhody k sozdaniiu lekarstvennykh sredstv s khondroprotektornymy svoĭstvami.