[Effect of plasma and plasma components on lymphocyte transformation].
Blood transfusions have an immunosuppressive effect on the recipient and induce changes of several immunological parameters. We therefore studied the effect of homologous and autologous fresh plasma, fresh-frozen plasma, heparinized plasma, as well as the influence of i.v. immunoglobulins on the MLC- and mitogen-induced lymphocyte transformation. We conclude from our study that, besides unspecific mechanisms, an unknown plasma factor enriched in the immunoglobulin fraction suppresses the MLC- and mitogen-induced T-cell immune response.
Sibrowski
W
W
Universitätskliniken Münster, Institut für Transfusionsmedizin, BRD.
Brauer
P
P
Wegner
W
W
Kühnl
P
P
D006801:Humans; D007116:Immunization, Passive; D007136:Immunoglobulins / Q000276:immunology*; D008213:Lymphocyte Activation / Q000276:immunology*; D007959:Lymphocyte Culture Test, Mixed; D010587:Phagocytosis / Q000276:immunology; D010949:Plasma / Q000276:immunology*
D007136:Immunoglobulins
Der Einfluss von Plasma und Plasma-Komponenten auf die Lymphozyten-Transformation.