[Study on zinc resistance to the immunosuppression caused by cyclophosphamidum in the mouse].
Swiss mice were used to study the effect of zinc in antagonizing the suppressive action of Cy on the immune function and thymus structure. Mice (weighing 18-22 g) receiving daily dose of 0.2 mg zinc for 25 days did not show any change in peripheral WBC count, production of IgM antibody and thymus weight, but did display marked resistance to the reduction of WBC count and number of mature T lymphocyte, suppressed production of IgM antibody and decreased thymus weight due to administration of Cy.
Zhang
X H
XH
Biology Department, Shandong University, Jinan.
Wang
L
L
Dong
Z Z
ZZ
D000818:Animals; D003520:Cyclophosphamide; D005260:Female; D016867:Immunocompromised Host; D007075:Immunoglobulin M / Q000378:metabolism; D007958:Leukocyte Count / Q000187:drug effects; D008297:Male; D051379:Mice; D009929:Organ Size / Q000187:drug effects; D013431:Sulfates / Q000494:pharmacology* / Q000627:therapeutic use; D013601:T-Lymphocytes / Q000276:immunology*; D013950:Thymus Gland / Q000166:cytology; D015032:Zinc / Q000494:pharmacology* / Q000627:therapeutic use; D019287:Zinc Sulfate
D007075:Immunoglobulin M; D013431:Sulfates; D019287:Zinc Sulfate; D003520:Cyclophosphamide; D015032:Zinc