[Steroid hormone receptors in spontaneous testicular tumors in dogs].
Cytoplasmic receptors to androgens (AR), estrogens (ER), progesterone (PR) and glucocorticoids (GR) were studied in tumors and normal tissue of the testis in dogs. Peculiarities of distribution of receptors were assessed versus age and tumor histology. Benign Leydig cell tumors failed to reveal AR and ER. ER were more often detected in benign Sertoli cell tumors. Malignant seminomas and Sertoli cell tumors were characterized by higher occurrence and levels of AR, GR and PR than their benign counterparts. The results obtained can be used in studies of the activity of newly developed hormonal antitumor drugs against testicular tumors in dogs.
Golubeva
V A
VA
Kuz'mina
Z V
ZV
Gershteĭn
E S
ES
Ponomar'kov
V I
VI
Bassalyk
L S
LS
Blinnikova
M G
MG
D000375:Aging / Q000378:metabolism; D000818:Animals; D003593:Cytoplasm / Q000737:chemistry; D004283:Dog Diseases / Q000378:metabolism*; D004285:Dogs; D008297:Male; D011869:Radioligand Assay / Q000662:veterinary; D011944:Receptors, Androgen / Q000032:analysis; D011960:Receptors, Estrogen / Q000032:analysis; D011965:Receptors, Glucocorticoid / Q000032:analysis; D011980:Receptors, Progesterone / Q000032:analysis; D011987:Receptors, Steroid / Q000032:analysis*; D013736:Testicular Neoplasms / Q000737:chemistry / Q000662:veterinary*; D013737:Testis / Q000737:chemistry
D011944:Receptors, Androgen; D011960:Receptors, Estrogen; D011965:Receptors, Glucocorticoid; D011980:Receptors, Progesterone; D011987:Receptors, Steroid
Retseptory steroidnykh gormonov v spontannykh opukholiakh iaichka u sobak.