title: Relative bioavailability in man of noscapine administered in lozenges and mixture.
abstract: The bioavailability of noscapine base administered in lozenges in a dose of 100 mg to twelve healthy volunteers, in a study using an open balanced cross-over design, was compared with that of 100 mg of noscapine hydrochloride given perorally as a mixture. The bioavailability of noscapine after administration in lozenges was significantly higher than that after administration of the drug as a mixture. It is concluded that the lozenges containing noscapine base may be a valuable alternative to the conventional noscapine hydrochloride mixture.
authors.affiliation: Royal Danish School of Pharmacy, Department of Pharmaceutics, Universitetsparken, Copenhagen.
authors.forename: L N
authors.initials: LN
authors.lastname: Jensen
authors.forename: L L
authors.initials: LL
authors.lastname: Christrup
authors.forename: L
authors.initials: L
authors.lastname: Jacobsen
authors.forename: J
authors.initials: J
authors.lastname: Bonde
authors.forename: H
authors.initials: H
authors.lastname: Bundgaard
mesh_terms: D000328:Adult; D001682:Biological Availability; D005260:Female; D006801:Humans; D008297:Male; D009665:Noscapine / Q000008:administration & dosage / Q000493:pharmacokinetics*; D012996:Solutions; D013607:Tablets
chemical_list: D012996:Solutions; D013607:Tablets; D009665:Noscapine