The influence of glucose and saccharose on haemolytic action of HgCl2 in relation to the ionic strength of the incubating medium.
The haemolytic action of HgCl2 (0, 15 mmol.l-1) was studied in relation to the ionic strength and concentration of glucose and saccharose in incubating medium. Blood from 94 donors, aged 19-46 years were used in our experiments. In relation to the ionic strength the haemolytic action was characteristic with two maxima of haemolysis. The first at low ionic strength and second one at the high. Both maxima in solutions containing saccharose were significantly diminished in glucose. These facts show a negative influence of saccharose on the haemorheological properties of the erythrocyte membrane.
Nicák
A
A
Department of Pharmacology, Medical Faculty, Safárik University, Kosice.
Mojzis
J
J
D000328:Adult; D002478:Cells, Cultured; D003470:Culture Media / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D004912:Erythrocytes / Q000737:chemistry / Q000166:cytology / Q000187:drug effects / Q000502:physiology; D005947:Glucose / Q000494:pharmacology*; D006461:Hemolysis / Q000187:drug effects* / Q000502:physiology; D006801:Humans; D008565:Membrane Proteins / Q000032:analysis / Q000502:physiology; D008627:Mercuric Chloride / Q000494:pharmacology*; D008875:Middle Aged; D009994:Osmolar Concentration; D013395:Sucrose / Q000494:pharmacology*
D003470:Culture Media; D008565:Membrane Proteins; D008627:Mercuric Chloride; D013395:Sucrose; D005947:Glucose