[Changes in the adhesion between enterocytes in short-term exposures to blastomogens, retinol acetate and indomethacin].
The study was concerned with the effect of carcinogens and anticarcinogens on the rate of cell loss in the large bowel epithelium of mice. Intestinal carcinogens such as N-methyl-N-nitrosourea and 1.2-dimethylhydrazine were shown to cause a long-lasting decrease in enterocyte loss. Conversely, retinol acetate and indomethacin treatment enhanced cell loss both under normal conditions and in the presence of the carcinogens. The protective effect against N-methyl-N-nitrosourea was more apparent than against 1.2-dimethylhydrazine. The effect was more pronounced in Balb/c mice compared to AKR/J. A close correlation between the protective and the anticarcinogenic effects of the drugs was established. The data obtained suggest that retinol acetate and indomethacin cause reversion of specific early reaction of the large bowel epithelium to carcinogens and are most effective in application in the promotion phase of carcinogens.
Matveev
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D019813:1,2-Dimethylhydrazine; D000818:Animals; D016588:Anticarcinogenic Agents / Q000494:pharmacology*; D002273:Carcinogens / Q000494:pharmacology*; D002448:Cell Adhesion / Q000187:drug effects; D004127:Dimethylhydrazines / Q000494:pharmacology; D004224:Diterpenes; D004347:Drug Interactions; D007213:Indomethacin / Q000494:pharmacology*; D007413:Intestinal Mucosa / Q000166:cytology / Q000187:drug effects*; D007420:Intestine, Large / Q000166:cytology / Q000187:drug effects*; D008297:Male; D008770:Methylnitrosourea / Q000494:pharmacology; D051379:Mice; D008806:Mice, Inbred AKR; D008807:Mice, Inbred BALB C; D000084562:Retinyl Esters; D013997:Time Factors; D014801:Vitamin A / Q000031:analogs & derivatives* / Q000494:pharmacology
D016588:Anticarcinogenic Agents; D002273:Carcinogens; D004127:Dimethylhydrazines; D004224:Diterpenes; D000084562:Retinyl Esters; D014801:Vitamin A; C009166:retinol acetate; D008770:Methylnitrosourea; D019813:1,2-Dimethylhydrazine; D007213:Indomethacin
Izmenenie stseplennosti mezhdu énterotsitami pri kratkovremennykh vozdeĭstviiakh blastomogenov, retinola atsetata i indomteatsina.