Changes in endogenous prostacyclin in the rat brain during clinical death and after resuscitation.
By means of the radioimmunologic method changes of concentration of 6-keto-prostaglandin F1 alpha (PGF1 alpha)--the stable metabolite of prostacyclin in the rat brain have been evaluated during 5-min clinical death and up to 2 hrs after resuscitation. Ischemia did not produce significant changes of 6-keto-PGF1 alpha concentration in the brain. In the early postresuscitation period the concentration of 6-keto-PGF1 in the and 7-fold control values. Later the concentration of 6-keto-PGF1 alpha in the brain decreased reaching in 30 min a 3-fold the control level, and in 60 and 120 min after resuscitation control values. The reasons of unsuccessful therapy of ischemic stroke with prostacyclin are discussed.
Kapuściński
A
A
Department of Neuropathology, Polish Academy of Sciences, Warsaw.
D015121:6-Ketoprostaglandin F1 alpha / Q000032:analysis*; D000818:Animals; D001923:Brain Chemistry; D002545:Brain Ischemia / Q000188:drug therapy / Q000378:metabolism*; D002561:Cerebrovascular Disorders / Q000188:drug therapy; D011464:Epoprostenol / Q000494:pharmacology / Q000627:therapeutic use; D005260:Female; D011863:Radioimmunoassay; D051381:Rats; D017208:Rats, Wistar; D012151:Resuscitation
D015121:6-Ketoprostaglandin F1 alpha; D011464:Epoprostenol