Surfactant replacement therapy improves pulmonary mechanics in end-stage influenza A pneumonia in mice.
Surfactant replacement therapy may be a promising approach for treatment of respiratory failure caused by viral pneumonia. This study in mice demonstrates that during the development of lethal influenza A pneumonia, thorax-lung compliance (Ctl/kg) and lung volume at 5 cm H2O PEEP (V5/kg) significantly decrease (28 and 54%, respectively), whereas lung water content significantly increases (25%). Surfactant replacement therapy during the end stage of pneumonia significantly increases Ctl/kg (31%) and V5/kg (21%). Instillation of the vehicle for surfactant in control animals does not significantly affect Ctl/kg (5% decrease), but it significantly decreases V5/kg (25% decrease). Further, a new method for postmortem measurement of lung volumes in small laboratory animals based on Archimedes' principle is presented.
Van Daal
G J
GJ
Department of Anesthesiology, Erasmus University, Rotterdam, The Netherlands.
Bos
J A
JA
Eijking
E P
EP
Gommers
D
D
Hannappel
E
E
Lachmann
B
B
D000818:Animals; D009980:Influenza A virus; D008176:Lung Volume Measurements / Q000662:veterinary; D008297:Male; D051379:Mice; D009976:Orthomyxoviridae Infections / Q000503:physiopathology / Q000628:therapy*; D011024:Pneumonia, Viral / Q000382:microbiology / Q000503:physiopathology / Q000628:therapy*; D011663:Pulmonary Surfactants / Q000627:therapeutic use*; D015656:Respiratory Mechanics / Q000502:physiology
D011663:Pulmonary Surfactants