title: [Herpes simplex-associated exacerbation of Crohn's disease. Successful treatment with acyclovir].
abstract: Seven years ago, a now 25-year-old man was found to have Crohn's disease of the terminal ileum as well as of the transverse and sigmoid colon. Despite treatment with both corticosteroids and mesalazine the disease progressed and led to almost complete stenosis of the lumen of the sigmoid colon so that surgical intervention was planned. But because immunohistological examination of the small and large intestinal mucosa had demonstrated herpes simplex virus (HSV I + II) DNA, additional treatment with acyclovir appeared worth-while. The morphological and clinical findings indeed changed decisively, obviating surgery. If a virus infection is found to be a pathogenetic co-factor in a case of Crohn's disease, a therapeutic trial with a suitable antiviral agent seems reasonable.
authors.affiliation: Abteilung für Allgemeine Innere Medizin, Katharinenhospital, Stuttgart.
authors.forename: U
authors.initials: U
authors.lastname: Rüther
authors.forename: C
authors.initials: C
authors.lastname: Nunnensiek
authors.forename: H A
authors.initials: HA
authors.lastname: Müller
authors.forename: W
authors.initials: W
authors.lastname: Rupp
authors.forename: S
authors.initials: S
authors.lastname: Gförer
authors.forename: H
authors.initials: H
authors.lastname: Bader
authors.forename: S
authors.initials: S
authors.lastname: Stilz
authors.forename: P
authors.initials: P
authors.lastname: Jipp
mesh_terms: D000212:Acyclovir / Q000627:therapeutic use*; D000305:Adrenal Cortex Hormones / Q000627:therapeutic use; D000328:Adult; D000636:Aminosalicylic Acids / Q000627:therapeutic use; D000914:Antibodies, Viral / Q000032:analysis; D003424:Crohn Disease / Q000150:complications* / Q000188:drug therapy; D004279:DNA, Viral / Q000032:analysis; D006561:Herpes Simplex / Q000150:complications* / Q000188:drug therapy; D006801:Humans; D008297:Male; D019804:Mesalamine; D018139:Simplexvirus / Q000235:genetics / Q000276:immunology
chemical_list: D000305:Adrenal Cortex Hormones; D000636:Aminosalicylic Acids; D000914:Antibodies, Viral; D004279:DNA, Viral; D019804:Mesalamine; D000212:Acyclovir
vernacular_title: Herpes-simplex-assoziierte Exazerbation eines Morbus Crohn. Erfolgreiche Behandlung mit Aciclovir.