[The effect of ubiquinone-10 on the development of D-galactosamine-induced hepatitis in rats].
It has been shown that prophylactic administration of ubiquinone protects rats liver from the toxic damage by D-galactosamine both on ultrastructural and on cell levels. Ubiquinone administration prevents necrosis in hepatocytes and preserves their ability for compensatory reactions expressed in activation of protein-synthesis regulating structures in the cell. Ubiquinone decreases hyperfermentemia and hyperbilirubinemia as well as prevents the decrease in liver protein content caused by galactosamine. Ubiquinone exerts an antioxidant effect, blocking the induction of lipid peroxidation both in intact and hepatic rats.
Sugrobova
N P
NP
Medvednik
R S
RS
Efimova
L V
LV
Katarzhnova
T V
TV
Liubarev
A E
AE
Shaposhnikov
V M
VM
Obol'nikova
E A
EA
Poznanskaia
A A
AA
D000818:Animals; D056486:Chemical and Drug Induced Liver Injury / Q000201:enzymology / Q000209:etiology / Q000473:pathology / Q000517:prevention & control*; D004195:Disease Models, Animal; D004353:Drug Evaluation, Preclinical; D005688:Galactosamine; D008099:Liver / Q000187:drug effects / Q000201:enzymology / Q000648:ultrastructure; D008297:Male; D008854:Microscopy, Electron; D051381:Rats; D014451:Ubiquinone / Q000627:therapeutic use*
D014451:Ubiquinone; D005688:Galactosamine; C025204:Ubiquinone Q2
Vliianie ubikhinona-10 na razvitie D-galaktozaminovogo gepatita u krys.