[A study of immunocompetence of peptide hormones in human pericardium].
With RIA/HPLC and immunohistochemistry, the presence of angiotensin(A) and atrial natriuretic factor-like materials (ANF-LMs) was demonstrated in the pericardium of human and rats; the distributions of AII and ANF-LMs were found to be identical; AI was more than AII; renin activity was detected in the pericardium. There were three molecular forms of ANF-LMs in the pericardium. Mesothelial cells were the principal endocrine-secreting cells. AII and ANF-LMs of the pericardium were significantly increased in rheumatic heart disease. There were no correlations between plasma AII, ANF, urine AII, ANF and pericardial AII, ANF (P > 0.05). The data reported showed that the pericardium may have endocrine function under normal and abnormal conditions (heart failure) of the heart, in addition to its known mechanical properties.
Wen
S J
SJ
Xuan Wu Hospital, Capital Institute of Medicine, Beijng.
D000804:Angiotensin II / Q000378:metabolism*; D000818:Animals; D009320:Atrial Natriuretic Factor / Q000378:metabolism*; D006801:Humans; D007121:Immunocompetence; D007150:Immunohistochemistry; D010496:Pericardium / Q000737:chemistry* / Q000648:ultrastructure; D051381:Rats; D012083:Renin / Q000378:metabolism; D012214:Rheumatic Heart Disease / Q000378:metabolism
D000804:Angiotensin II; D009320:Atrial Natriuretic Factor; D012083:Renin