[ Dynamics of NAD-dependent isocitrate dehydrogenase activity in homogenized rat liver exposed to toxic products of the phosphorus industry].
Dynamic studies showed that the combined action of phosphine and hydrofluoric acid damages the Krebs cycle reactions, dehydrogenization of isocitrate and synthesis of citrate in homogenized rat liver. Yellow phosphorus harmed the citrate synthetic reaction of citric acid cycle in homogenized rat liver as well. That activated the alternative action principles in the cycle. The main cause of such disorders in the Krebs cycle in likely to be the abnormal fat metabolism induced by toxic products of phosphorus industry.
Kulkybaev
G A
GA
Merkusheva
N V
NV
D000818:Animals; D002952:Citric Acid Cycle; D005500:Follow-Up Studies; D006858:Hydrofluoric Acid / Q000494:pharmacology / Q000633:toxicity*; D007521:Isocitrate Dehydrogenase / Q000096:biosynthesis / Q000187:drug effects*; D008099:Liver / Q000187:drug effects* / Q000201:enzymology; D008297:Male; D008954:Models, Biological; D010720:Phosphines / Q000494:pharmacology / Q000633:toxicity; D010758:Phosphorus / Q000494:pharmacology / Q000633:toxicity*; D051381:Rats
D010720:Phosphines; D010758:Phosphorus; D007521:Isocitrate Dehydrogenase; C044646:phosphine; D006858:Hydrofluoric Acid
Dinamika akivnosti NAD-zavisimoĭ izotsitratdegidrogenazy v gomogenatakh pecheni krys pod deĭstviem vrednykh veshchestv fosfornogo proizvodstva.