title: Synthesis and property of alpha-oligodeoxynucleotide phosphorothioate.
abstract: Unnatural DNA analog, alpha-2'-deoxy-oligoadenylate phosphorothioate bearing 3'-normal monophosphate moiety was conveniently synthesized through phosphoramidite solid support method. The starting material of the DNA analog, alpha-2'-deoxyadenosine, was prepared in a stereospecific manner by the coupling reaction between activated nucleobase and 1-chloro-2-deoxyribose derivative.
authors.affiliation: Department of Chemistry, Faculty of Engineering, Gunma University, Kiryu City, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Shinozuka
authors.forename: Y
authors.initials: Y
authors.lastname: Hirota
authors.forename: T
authors.initials: T
authors.lastname: Morita
authors.forename: H
authors.initials: H
authors.lastname: Sawai
mesh_terms: D000227:Adenine Nucleotides / Q000138:chemical synthesis* / Q000737:chemistry; D003839:Deoxyadenosines / Q000737:chemistry; D015394:Molecular Structure; D013873:Thionucleotides / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D000227:Adenine Nucleotides; D003839:Deoxyadenosines; D013873:Thionucleotides