[The metabolic interaction of cobalt and silver in the body during their combined action].
Mixtures of cobalt and silver in ratio (0.2:0.4), (0.2:0.2) and (0.2:0.1) mg/kg were once administrated intraperitoneally and intratracheally to white rats. Metabolism of the metals was studied. Combined exposure to metals appeared to influence greatly on their toxicokinetics. The co-action between metals appears during their absorption into the blood--the elevated peritoneal absorption of cobalt depresses that of silver. The reverse relationship is demonstrated during the intratracheal insertion. Such peculiarities of co-action exist during the further stages of metabolism.
Kazimov
M A
MA
D000042:Absorption; D000818:Animals; D003035:Cobalt / Q000008:administration & dosage / Q000493:pharmacokinetics* / Q000633:toxicity; D004347:Drug Interactions; D006207:Half-Life; D051381:Rats; D012834:Silver / Q000008:administration & dosage / Q000493:pharmacokinetics* / Q000633:toxicity; D013997:Time Factors; D014018:Tissue Distribution
D003035:Cobalt; D012834:Silver
Netabolicheskoe vzaimodeĭstvie kobal'ta i serebra v organizme v usloviiakh kombinirovannogo deĭstviia.