[Effect of sodium artesunate on Plasmodium yoelii analysed by flow cytometry].
The effect of sodium artesunate on Plasmodium yoelii-infected mouse erythrocytes was analysed by flow cytometry. The results showed that malarial DNA content in experimental group was obviously decreased 2-5 hours after the drug was administered, fluorescence distribution of malarial DNA almost disappeared within 24 hours after the administration. Thus we deem that sodium artesunate can inhibit the DNA synthesis in P. yoelii.
Han
W S
WS
Department of Parasitology, Hebei Medical College, Shijiazhuang.
Zhou
W Q
WQ
Wang
B X
BX
Li
Z M
ZM
Zuo
L F
LF
Guo
J W
JW
D000818:Animals; D000962:Antimalarials / Q000494:pharmacology*; D037621:Artemisinins; D000077332:Artesunate; D016054:DNA, Protozoan / Q000378:metabolism*; D005260:Female; D005434:Flow Cytometry; D008297:Male; D051379:Mice; D010967:Plasmodium yoelii / Q000187:drug effects* / Q000235:genetics; D012717:Sesquiterpenes / Q000494:pharmacology*
D000962:Antimalarials; D037621:Artemisinins; D016054:DNA, Protozoan; D012717:Sesquiterpenes; D000077332:Artesunate