The evaluation of 6-amidino-2-naphthyl 4-[(4,5-dihydro-1H-imidazol-2-yl)amino] benzoate dimethanesulfonate (FUT-187) by oral administration in cynomolgus monkeys in a 13 week subacute toxicity study.
To assess the subacute toxicity of 6-amidino-2-naphthyl 4-[(4,5-dihydro-1H-imidazol-2-yl)amino] benzoate dimethanesulfonate (FUT-187) a 13 week subacute toxicity study by gavage was done in Cynomolgus monkeys at dosage levels of 0, 15, 45 and 135 mg/kg/day. Deaths were seen in the 135 mg/kg/day group; with associated debility. The animals that died had high plasma levels of FUT-187. Little weight gain was seen in the 135 mg/kg/day group. There were no clear treatment related effects on ophthalmoscopy or electrocardiography or on hematological, biochemical or urinalysis. There were no effects noted at necropsy or on histopathology and the causes of death for each of the 3 animals that died were suppurative glomerulonephritis, bone marrow depression and possible gavage injury respectively. The no-effect level for toxicology was considered to be 45 mg/kg/day.
Spicer
E J
EJ
International Research and Development Corp., Mattawan, MI 49071.
Maruden
A
A
Terazawa
K
K
D000284:Administration, Oral; D000818:Animals; D001835:Body Weight / Q000187:drug effects; D004334:Drug Administration Schedule; D004435:Eating / Q000187:drug effects; D004562:Electrocardiography / Q000187:drug effects; D006403:Hematologic Tests; D007093:Imidazoles / Q000008:administration & dosage / Q000493:pharmacokinetics / Q000633:toxicity*; D008252:Macaca fascicularis; D008297:Male; D009929:Organ Size / Q000187:drug effects; D013997:Time Factors; D014018:Tissue Distribution; D016482:Urinalysis
D007093:Imidazoles; C058875:sepimostate mesilate