title: Electrical stimulation-evoked release of endogenous taurine from slices of the hippocampus, cerebral cortex and cerebellum of the rat.
abstract: Release of endogenous taurine by electrical stimulation of slices of the hippocampus, cerebral cortex, cerebellum and medulla oblongata of the rat was studied and compared with that of alanine and/or gamma-aminobutyric acid (GABA). Electrical stimulation caused a calcium-dependent release of taurine from slices of the hippocampus, cerebral cortex and cerebellum but not from slices of the medulla oblongata. The stimulus-evoked release of taurine in the hippocampus was rapid in onset and declined to baseline fast, which was essentially similar to the time course pattern of the stimulus-evoked release of GABA. In addition, there were distinct regional differences in the relative amounts of taurine released. Electrical stimulation did not release alanine from any regions examined. These results support the hypothesis that taurine plays a neurotransmitter role in the hippocampus, cerebral cortex and cerebellum of the rat.
authors.affiliation: Department of Pharmacology, Showa College of Pharmaceutical Sciences, Tokyo, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Kubo
authors.forename: A
authors.initials: A
authors.lastname: Takano
authors.forename: N
authors.initials: N
authors.lastname: Tokushige
authors.forename: N
authors.initials: N
authors.lastname: Miyata
authors.forename: M
authors.initials: M
authors.lastname: Sato
authors.forename: S
authors.initials: S
authors.lastname: Hatakeyama
mesh_terms: D000409:Alanine / Q000378:metabolism; D000818:Animals; D001923:Brain Chemistry / Q000502:physiology*; D002118:Calcium / Q000502:physiology; D002531:Cerebellum / Q000378:metabolism / Q000502:physiology; D002540:Cerebral Cortex / Q000378:metabolism / Q000502:physiology; D002851:Chromatography, High Pressure Liquid; D004558:Electric Stimulation; D006624:Hippocampus / Q000378:metabolism / Q000502:physiology; D008297:Male; D008526:Medulla Oblongata / Q000378:metabolism / Q000502:physiology; D051381:Rats; D017208:Rats, Wistar; D013654:Taurine / Q000378:metabolism*; D005680:gamma-Aminobutyric Acid / Q000378:metabolism
chemical_list: D013654:Taurine; D005680:gamma-Aminobutyric Acid; D000409:Alanine; D002118:Calcium