[The effect of diphosphonates on the metabolism of calcium, its regulation and the state of the bone tissue in the modelling of the physiological effects of weightlessness].
The diphosphonates AMOA and OEDP had a positive action on calcium metabolism and regulation and the osseous tissue in tilt-suspension and hypokinetic Wistar rats in 40-60-day experiments. During special regimens of physical training, ksidifon (OEDP) produced preventive effects on calcium metabolism and renal calciuretic function in man during 120-day antiorthostatic hypokinesia and the agent may be recommended for prevention of alterations in mineral metabolism and osseous tissue at long-term bed rest.
Orlov
O I
OI
Shashkov
V S
VS
Grigor'ev
A I
AI
D000818:Animals; D001510:Bed Rest / Q000009:adverse effects; D015519:Bone Density / Q000187:drug effects / Q000502:physiology; D001842:Bone and Bones / Q000187:drug effects* / Q000378:metabolism; D002118:Calcium / Q000378:metabolism*; D004164:Diphosphonates / Q000494:pharmacology* / Q000627:therapeutic use; D004341:Drug Evaluation; D004353:Drug Evaluation, Preclinical; D006801:Humans; D007103:Immobilization / Q000009:adverse effects / Q000502:physiology; D007668:Kidney / Q000187:drug effects / Q000502:physiology; D008297:Male; D011187:Posture / Q000502:physiology; D051381:Rats; D017208:Rats, Wistar; D013997:Time Factors; D014893:Weightlessness / Q000009:adverse effects*
D004164:Diphosphonates; D002118:Calcium
Vliianie difosfonatov na obmen kal'tsiia, ego reguliatsiiu i sostoianie kostnoĭ tkani pri modelirovanii fiziologicheskikh éffektov nevesomosti.