title: [The role of endogenous opioids in modulation of immunosuppression in fish].
abstract: We have previously shown that social confrontation between aggressive fish (e.g., Tilapia) produces a suppression of several immunological parameters--nonspecific cytotoxicity and mitogen-stimulated proliferation in pronephric lymphocytes--in the subordinate fish. By using the opioid antagonist, naltrexone, we now demonstrate indirectly that this immunosuppression is in part mediated by the endogenous opioid system. Evidence is presented that naltrexone-mediated reversal of immunosuppression may be limited to the populations of the cytotoxic and T-cell lineages. The proliferative response to lipopolysaccharide is unaffected by naltrexone. Our data also demonstrate that serum from subordinate (immunosuppressed) fish is immunosuppressive in normal fish: an effect that can be reversed by naltrexone. These results support a link between the neuroendocrine and immune systems in these animals.
authors.forename: M
authors.initials: M
authors.lastname: Faisal
authors.forename: F
authors.initials: F
authors.lastname: Chiappelli
authors.forename: I I
authors.initials: II
authors.lastname: Ahmed
authors.forename: E L
authors.initials: EL
authors.lastname: Cooper
authors.forename: H
authors.initials: H
authors.lastname: Weiner
mesh_terms: D000374:Aggression / Q000187:drug effects / Q000502:physiology; D000818:Animals; D001143:Arousal / Q000187:drug effects / Q000502:physiology; D003602:Cytotoxicity, Immunologic / Q000187:drug effects / Q000502:physiology; D004291:Dominance-Subordination; D004723:Endorphins / Q000502:physiology*; D007108:Immune Tolerance / Q000187:drug effects / Q000502:physiology*; D008213:Lymphocyte Activation / Q000187:drug effects / Q000502:physiology; D009271:Naltrexone / Q000494:pharmacology; D017210:Tilapia
chemical_list: D004723:Endorphins; D009271:Naltrexone
vernacular_title: Die Rolle endogener Opioide in der Modulation der Immunsuppression bei Fischen.