title: Cutaneous cryptococcosis: recurrence following oral fluconazole treatment.
abstract: A case of recurrent cutaneous cryptococcosis in an immunocompromised patient is described. The patient presented with a non-healing cutaneous ulcer due to infection with Cryptococcus neoformans. Extensive investigation failed to reveal any evidence of associated systemic cryptococcosis. Treatment with oral fluconazole resulted in complete resolution of the ulcer but after several months a second cutaneous cryptococcal lesion appeared, strongly suggesting dissemination from an underlying systemic focus. This case illustrates the hazards associated with making a diagnosis of isolated cutaneous cryptococcosis and the necessity for prolonged follow-up of patients who present in this way.
authors.affiliation: Department of Microbiology and Infectious Diseases, Flinders Medical Centre, Bedford Park, South Australia.
authors.forename: C M
authors.initials: CM
authors.lastname: Cooper
authors.forename: D L
authors.initials: DL
authors.lastname: Gordon
authors.forename: C
authors.initials: C
authors.lastname: Reid
authors.forename: C R
authors.initials: CR
authors.lastname: Philpot
mesh_terms: D000284:Administration, Oral; D000368:Aged; D003453:Cryptococcosis / Q000188:drug therapy*; D003881:Dermatomycoses / Q000188:drug therapy*; D005260:Female; D015725:Fluconazole / Q000627:therapeutic use*; D006801:Humans; D012008:Recurrence
chemical_list: D015725:Fluconazole