Effect of HDL1 infusion on biliary secretion in perfused rat liver.
The effects of HDL1 lipoprotein infusion on biliary lipid secretion were studied in the in vitro model of rat perfused liver. A strong increase in bile flow was observed during and after lipoprotein infusion. This caused a significant rise in cholesterol, phospholipid and bile salt secretions. However, only the percentage of cholesterol increased with respect to the other bile lipids. The changes observed in the cholesterol/phospholipid molar ratio values of liver membrane subfractions (i.e., liver plasma membrane, mitochondria plus lysosomes and microsomes) isolated from the perfused rat liver after HDL1 administration were not significant.
Rivabene
R
R
Istituto Superiore di Sanità, Laboratory of Metabolism and Pathological Biochemistry, Rome, Italy.
Cantafora
A
A
Yan
C C
CC
Castellano
F
F
Bruscalupi
G
G
Bravo
E
E
D000818:Animals; D001646:Bile / Q000378:metabolism; D001647:Bile Acids and Salts / Q000378:metabolism; D002784:Cholesterol / Q000378:metabolism; D007425:Intracellular Membranes / Q000378:metabolism; D008075:Lipoproteins, HDL / Q000008:administration & dosage / Q000378:metabolism*; D008099:Liver / Q000187:drug effects / Q000378:metabolism*; D008297:Male; D010743:Phospholipids / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar
D001647:Bile Acids and Salts; D008075:Lipoproteins, HDL; D010743:Phospholipids; D002784:Cholesterol