The function relating the subjective magnitude of brain stimulation reward to stimulation strength varies with site of stimulation.
A two-lever choice paradigm with concurrent variable interval schedules of reward was used to measure the growth in the subjective magnitude of reward as a function of current, by finding the adjustment in the stimulating current required to offset a given difference in the rates at which two rewards were received. Increasing current by a factor of 2 increased subjective reward magnitude by a factor ranging from as little as 3 to as much as 4,000. This range was about as great between electrodes within one rat as between electrodes and rats. In the light of earlier findings regarding the equivalent effects of increments is current and pulse frequency, these large differences cannot readily be explained by differing fiber densities at the site of stimulation. It is suggested that the medial forebrain bundle terminates in more than one spatio-temporal integration mechanism. The magnitude of the spatio-temporally integrated effect of a barrage of action potentials in the reward-relevant axons depends on which subset of reward-relevant axons is excited by the stimulation.
Leon
M
M
Department of Psychology, University of California, Los Angeles 90024-1563.
Gallistel
C R
CR
D000200:Action Potentials / Q000502:physiology; D000818:Animals; D001369:Axons / Q000502:physiology; D001921:Brain / Q000502:physiology*; D003216:Conditioning, Operant / Q000502:physiology; D004558:Electric Stimulation; D004567:Electrodes, Implanted; D007033:Hypothalamus, Middle / Q000033:anatomy & histology / Q000502:physiology; D007034:Hypothalamus, Posterior / Q000033:anatomy & histology / Q000502:physiology; D008297:Male; D008474:Medial Forebrain Bundle / Q000033:anatomy & histology / Q000502:physiology; D009412:Nerve Fibers / Q000502:physiology; D051381:Rats; D017207:Rats, Sprague-Dawley; D012055:Reinforcement Schedule; D012201:Reward; D013238:Stereotaxic Techniques; D013681:Tegmentum Mesencephali / Q000033:anatomy & histology / Q000502:physiology