[Value of intravesically instilled oxybutynin in refractory bladder hyperactivity. Study of 15 cases].
15 patients with neurogenic detrusor hyperactivity refractory to oral anticholinergics received a daily intravesical instillation of 5 mg of oxybutinin for 6 days. An improvement was observed clinically in 10 cases and on urodynamic parameters (60% increase in bladder capacity, doubling of the volume inducing an urge to void) in 12 cases. The mechanism of action is discussed.
Amarenco
G
G
Laboratoire d'Urodynamique et de Neurophysiologie, Hôpital Robert Ballanger, Aulnay-sous-Bois.
Adba
M A
MA
Kerdraon
J
J
D000283:Administration, Intravesical; D000328:Adult; D000368:Aged; D005260:Female; D006801:Humans; D008297:Male; D008333:Mandelic Acids / Q000008:administration & dosage* / Q000627:therapeutic use; D008875:Middle Aged; D010276:Parasympatholytics / Q000008:administration & dosage* / Q000627:therapeutic use; D001750:Urinary Bladder, Neurogenic / Q000188:drug therapy*
D008333:Mandelic Acids; D010276:Parasympatholytics; C005419:oxybutynin
Intérêt de l'oxybutinine en instillation intra-vésicale dans les hyperactivités vésicales rebelles. Etude de 15 patients.