Memory dysfunction following disruption of glutamergic systems in the temporal region of the rat: effects of agonistic amino acids.
It has previously been shown that disruptions of fiber connections between the temporal cortex (TC) and the lateral entorhinal cortex (LEC) in rats result in severely impaired retention of a simultaneous brightness discrimination task. This memory impairment is accompanied by reduced high affinity D-aspartate uptake in both TC and LEC. The purpose of this study was to investigate whether systemic administration of glutamergic agonists might ameliorate the mnemonic dysfunction seen to follow TC/LEC transections. The results from Experiment 1 show that agonists acting selectively at the NMDA receptors (NMDA and glycine) or the quisqualate receptors (AMPA) produced complete amelioration of the memory deficit. Injection of kainic acid only produced a slight improvement of memory. The results from Experiment 2 show that the positive effects of agonists are probably not attributable to peripheral adrenergic mechanisms, because blockade of sympathetic terminal release did not prevent mitigating effect of glycine. The results are discussed in terms of possible central nervous mechanisms interfered with by the various agonists.
Myhrer
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Norweigan Defence Research Establishment, Division for Environmental Toxicology, Kjeller.
Paulsen
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D000596:Amino Acids / Q000494:pharmacology*; D000818:Animals; D001949:Bretylium Compounds / Q000494:pharmacology; D004193:Discrimination Learning / Q000187:drug effects; D004837:Epinephrine / Q000494:pharmacology; D007274:Injections, Intraperitoneal; D008297:Male; D008569:Memory Disorders / Q000139:chemically induced*; D009411:Nerve Endings / Q000187:drug effects / Q000378:metabolism; D011897:Random Allocation; D051381:Rats; D017208:Rats, Wistar; D017470:Receptors, Glutamate / Q000187:drug effects*; D012153:Retention, Psychology / Q000187:drug effects; D013564:Sympathetic Nervous System / Q000187:drug effects / Q000378:metabolism; D013702:Temporal Lobe / Q000187:drug effects*
D000596:Amino Acids; D001949:Bretylium Compounds; D017470:Receptors, Glutamate; C045166:bretylium; D004837:Epinephrine