title: Twenty-four year spironolactone therapy in an aged patient with aldosterone-producing adenoma.
abstract: A case of primary aldosteronism treated with spironolactone therapy has been followed up for 24 years. This is probably the longest case of spironolactone therapy for primary aldosteronism that has ever been reported. Long-term treatment with spironolactone controlled the hypertension and prevented hypokalemic alkalosis in this patient, without any deleterious effects on steroid biosynthesis. Based on data obtained during dose reduction and subsequent withdrawal of spironolactone, it is suggested that the suppressed plasma renin activity associated with adenoma-induced aldosteronism develops prior to hypokalemia and hypertension.
authors.affiliation: Second Department of Internal Medicine, Kanazawa University, Japan.
authors.forename: R
authors.initials: R
authors.lastname: Takeda
authors.forename: T
authors.initials: T
authors.lastname: Yamazaki
authors.forename: Y
authors.initials: Y
authors.lastname: Ito
authors.forename: H
authors.initials: H
authors.lastname: Koshida
authors.forename: T
authors.initials: T
authors.lastname: Morise
authors.forename: I
authors.initials: I
authors.lastname: Miyamori
authors.forename: T
authors.initials: T
authors.lastname: Hashimoto
authors.forename: S
authors.initials: S
authors.lastname: Morimoto
mesh_terms: D000236:Adenoma / Q000150:complications / Q000188:drug therapy* / Q000473:pathology; D000310:Adrenal Gland Neoplasms / Q000150:complications / Q000188:drug therapy* / Q000473:pathology; D000311:Adrenal Glands / Q000473:pathology; D000324:Adrenocorticotropic Hormone; D000368:Aged; D000450:Aldosterone / Q000097:blood; D005260:Female; D006801:Humans; D006854:Hydrocortisone / Q000097:blood; D006929:Hyperaldosteronism / Q000188:drug therapy / Q000209:etiology*; D006973:Hypertension / Q000188:drug therapy / Q000209:etiology; D007008:Hypokalemia / Q000209:etiology; D008279:Magnetic Resonance Imaging; D012083:Renin / Q000097:blood; D013148:Spironolactone / Q000627:therapeutic use*
chemical_list: D013148:Spironolactone; D000450:Aldosterone; D000324:Adrenocorticotropic Hormone; D012083:Renin; D006854:Hydrocortisone