title: Neurobiological mechanisms in cocaine and opiate dependence.
authors.affiliation: Department of Neuropharmacology, Scripps Research Institute, La Jolla, California 92037.
authors.forename: G F
authors.initials: GF
authors.lastname: Koob
mesh_terms: D000818:Animals; D001921:Brain / Q000187:drug effects* / Q000503:physiopathology*; D003042:Cocaine / Q000009:adverse effects; D004298:Dopamine / Q000502:physiology; D006801:Humans; D009042:Motivation; D009293:Opioid-Related Disorders / Q000503:physiopathology*; D012653:Self Stimulation / Q000187:drug effects / Q000502:physiology; D013375:Substance Withdrawal Syndrome / Q000503:physiopathology; D019966:Substance-Related Disorders / Q000503:physiopathology*; D009435:Synaptic Transmission / Q000187:drug effects* / Q000502:physiology*
chemical_list: D003042:Cocaine; D004298:Dopamine