title: Cold fingers in leprosy.
abstract: Under conditions of maximal thermoregulatory peripheral dilatation, most healthy subjects (both Indian and European) showed raised blood flow in the fingertips (measured by laser Doppler flowmetry) where the skin temperature is only slightly lower than the core body temperature. Most borderline lepromatous (BL) leprosy patients had much colder fingers and the blood flow was slow: borderline tuberculoid (BT) patients had skin temperatures similar to those seen in healthy subjects, but their fingertip blood flow was reduced relative to that in control subjects. The occurrence of cold fingers and slow blood flow was clearly associated with evidence of sensory impairment to light touch, pressure and temperature. Slower fingertip blood flow was strongly associated with impairment of vasomotor control in this anatomical region, suggesting that both may be a consequence of leprosy peripheral neuropathy, at least in patients with early leprosy, but it is likely that leprosy arteriopathy may contribute to the lowered peripheral perfusion in advanced cases. It is suggested that the simple clinical sign of cold fingers may be of value in the preliminary assessment of patients presenting at any leprosy control clinic in the tropics.
authors.affiliation: Department of Pathology, University of Dundee, U.K.
authors.forename: N C
authors.initials: NC
authors.lastname: Abbot
authors.forename: J S
authors.initials: JS
authors.lastname: Beck
authors.forename: P D
authors.initials: PD
authors.lastname: Samson
authors.forename: C R
authors.initials: CR
authors.lastname: Butlin
authors.forename: P J
authors.initials: PJ
authors.lastname: Bennett
authors.forename: J M
authors.initials: JM
authors.lastname: Grange
mesh_terms: D000328:Adult; D001783:Blood Flow Velocity; D005385:Fingers / Q000098:blood supply / Q000502:physiology*; D006801:Humans; D017078:Laser-Doppler Flowmetry; D015439:Leprosy, Borderline / Q000503:physiopathology*; D015441:Leprosy, Tuberculoid / Q000503:physiopathology*; D012677:Sensation / Q000502:physiology; D012684:Sensory Thresholds; D012867:Skin / Q000098:blood supply; D012881:Skin Temperature