[Neonatal isoimmune thrombocytopenia by anti-GP IIb/IIIa].
Neonatal alloimmune thrombocytopenic purpura is caused by maternal platelet-specific alloantibodies which react on fetal platelets with the corresponding antigen. We describe a 30-year-old female patient with type I Glanzmann thrombasthenia who developed an isoantibody against the platelet GP IIb/IIIa complex before or during pregnancy. The platelet count in the male newborn was 35 x 10(9)/l, but there were no signs of cerebral hemorrhage. Following infusion of 2 g/day i.v. IgG on 3 consecutive days, platelet counts rose to normal values. An isoantibody reacting with the GP IIb/IIIa complex of all platelet donors tested was found in the maternal serum using the MAIPA assay. Thus, immune-mediated neonatal thrombocytopenia may be caused by platelet isoantibodies against GP IIb/IIIa as well as by platelet-specific alloantibodies and by maternal autoantibodies.
Kiefel
V
V
Institut für klinische Immunologie und Transfusionsmedizin, Justus-Liebig-Universität Giessen, BRD.
Meyer
E
E
Greinacher
A
A
Kroll
H
H
Mueller-Eckhardt
C
C
D000328:Adult; D001327:Autoimmune Diseases / Q000097:blood / Q000235:genetics*; D001788:Blood Grouping and Crossmatching; D001792:Blood Platelets / Q000276:immunology; D005260:Female; D005455:Fluorescent Antibody Technique; D006801:Humans; D007231:Infant, Newborn; D007518:Isoantibodies / Q000097:blood*; D008297:Male; D010976:Platelet Count; D010980:Platelet Membrane Glycoproteins / Q000235:genetics / Q000276:immunology*; D011247:Pregnancy; D013915:Thrombasthenia / Q000097:blood / Q000235:genetics*; D013921:Thrombocytopenia / Q000097:blood / Q000235:genetics*
D007518:Isoantibodies; D010980:Platelet Membrane Glycoproteins
Neonatale Isoimmunthrombozytopenie durch Anti-GP IIb/IIIa.