title: [The effect of amiridin on the MPTP-induced Parkinson-like syndrome in monkeys].
abstract: Development of behavioral disturbances was investigated during N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) administration (0,2 mg/kg, i/m, at 48 h. intervals, total dose 11.2-13.2 mg/kg) in experiments on two monkeys Macaca rhesus. MPTP induced the complex of symptoms, which are typical for idiopathic Parkinson's disease. Administration of amiridine (0,25-0,4 mg/kg) to MPTP-treated monkeys caused gradual decline of Parkinson syndrome. Mechanisms of action of amiridine are discussed.
authors.forename: Iu V
authors.initials: IuV
authors.lastname: Burov
authors.forename: S E
authors.initials: SE
authors.lastname: Metkalova
authors.forename: A E
authors.initials: AE
authors.lastname: Kustov
authors.forename: G V
authors.initials: GV
authors.lastname: Petrov
authors.forename: V V
authors.initials: VV
authors.lastname: Shul'govskiĭ
mesh_terms: D015632:1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; D000634:Aminoquinolines / Q000627:therapeutic use*; D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects; D002800:Cholinesterase Inhibitors; D004195:Disease Models, Animal; D004353:Drug Evaluation, Preclinical; D005260:Female; D008253:Macaca mulatta; D008297:Male; D010302:Parkinson Disease, Secondary / Q000139:chemically induced / Q000188:drug therapy*; D011619:Psychotropic Drugs / Q000627:therapeutic use*; D013997:Time Factors
chemical_list: D000634:Aminoquinolines; D002800:Cholinesterase Inhibitors; D011619:Psychotropic Drugs; D015632:1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; C049860:amiridine
vernacular_title: Vliianie amiridina na MFTP-indutsirovannyĭ parkinsonpodobnyĭ sindrom u obez'ian.