[A comparative study of the individual characteristics of the excretion of metabolites of benzo(a)pyrene and its carcinogenic effect in rats].
Nineteen outbred LIO rats received a single intraperitoneal injection of 200 mg/kg benzo(a)pyrene (BP) in sunflower oil. Levels of excretion of a BP activation product 7.8-BP-dihydrodiol and deactivation product 3-hydroxy-BP showed significant individual variations. Half the animals developed intraperitoneal sarcoma at various stages of the experiment. A direct correlation between urine 7.8-BP-dihydrodiol excretion level and tumor latency was established. The value of metabolite excretion level monitoring for making individual prognosis of BP carcinogenic effect is discussed.
Zabezhinskiĭ
M A
MA
Dikun
P P
PP
Savochkina
I V
IV
Tyndyk
M L
ML
Filatov
V N
VN
Likhachev
A Ia
AIa
D000818:Animals; D001564:Benzo(a)pyrene / Q000032:analysis / Q000493:pharmacokinetics* / Q000633:toxicity*; D001580:Benzopyrenes / Q000032:analysis / Q000493:pharmacokinetics; D004101:Dihydroxydihydrobenzopyrenes / Q000032:analysis / Q000493:pharmacokinetics; D005243:Feces / Q000737:chemistry; D016018:Least-Squares Analysis; D008297:Male; D009374:Neoplasms, Experimental / Q000139:chemically induced* / Q000453:epidemiology / Q000378:metabolism; D011336:Probability; D051381:Rats; D012044:Regression Analysis; D013997:Time Factors
D001580:Benzopyrenes; D004101:Dihydroxydihydrobenzopyrenes; C017228:benzo(a)pyrene 7,8-dihydrodiol; D001564:Benzo(a)pyrene; C021338:3-hydroxybenzo(a)pyrene
Sravnitel'noe izuchenie individual'nykh osobennosteĭ ékskretsii metabolitov benz(a)pirena i ego kantserogennogo éffekta u krys.