title: [Paradoxical reaction to midazolam after its use as a sedative in regional anesthesia].
abstract: We report 3 cases of paradoxical reaction to midazolam after being used for sedation during regional anesthesia. The picture was characterized by a marked aggressiveness. In one case the reaction was treated with general anesthesia, whereas in the other two patients the clinical picture was rapidly reversed by administration of flumazenil. We describe the possible causative mechanisms of this reaction as well as their treatment.
authors.affiliation: Departamento de Anestesiología y Reanimación, Hospital Universitario, Granada.
authors.forename: A
authors.initials: A
authors.lastname: Martínez-Tellería
authors.forename: M E
authors.initials: ME
authors.lastname: Cano
authors.forename: R
authors.initials: R
authors.lastname: Carlos
mesh_terms: D000293:Adolescent; D000328:Adult; D000374:Aggression / Q000187:drug effects*; D017109:Akathisia, Drug-Induced / Q000188:drug therapy / Q000209:etiology*; D000765:Anesthesia, Conduction; D000767:Anesthesia, Epidural; D000773:Anesthesia, Obstetrical; D005260:Female; D005442:Flumazenil / Q000627:therapeutic use; D006801:Humans; D006993:Hypnotics and Sedatives / Q000009:adverse effects*; D007431:Intraoperative Complications / Q000139:chemically induced* / Q000188:drug therapy; D008297:Male; D008874:Midazolam / Q000009:adverse effects* / Q000494:pharmacology; D010276:Parasympatholytics / Q000009:adverse effects; D011247:Pregnancy; D016728:Self-Injurious Behavior / Q000139:chemically induced
chemical_list: D006993:Hypnotics and Sedatives; D010276:Parasympatholytics; D005442:Flumazenil; D008874:Midazolam
vernacular_title: Reacción paradójica al midazolam tras su uso como sedante en anestesia regional.