Genetic evidence for a novel familial Alzheimer's disease locus on chromosome 14.
Familial Alzheimer's disease (FAD) has been shown to be genetically heterogeneous, with a very small proportion of early onset pedigrees being associated with mutations in the amyloid precursor protein (APP) gene on chromosome 21, and some late onset pedigrees showing associations with markers on chromosome 19. We now provide evidence for a major early onset FAD locus on the long arm of chromosome 14 near the markers D14S43 and D14S53 (multipoint lod score z = 23.4) and suggest that the inheritance of FAD may be more complex than had initially been suspected.
St George-Hyslop
P
P
Dept. of Medicine, University of Toronto, Ontario, Canada.
Haines
J
J
Rogaev
E
E
Mortilla
M
M
Vaula
G
G
Pericak-Vance
M
M
Foncin
J F
JF
Montesi
M
M
Bruni
A
A
Sorbi
S
S
Rainero
I
I
Pinessi
L
L
Pollen
D
D
Polinsky
R
R
Nee
L
L
Kennedy
J
J
Macciardi
F
F
Rogaeva
E
E
Liang
Y
Y
Alexandrova
N
N
Lukiw
W
W
Schlumpf
K
K
Tanzi
R
R
Tsuda
T
T
Farrer
L
L
Cantu
J M
JM
Duara
R
R
Amaducci
L
L
Bergamini
L
L
Gusella
J
J
Roses
A
A
Crapper McLachlan
D
D
D000368:Aged; D000483:Alleles; D000544:Alzheimer Disease / Q000235:genetics*; D016564:Amyloid beta-Protein Precursor / Q000235:genetics; D001483:Base Sequence; D002874:Chromosome Mapping; D002883:Chromosomes, Human, Pair 14; D004247:DNA / Q000235:genetics; D005260:Female; D005819:Genetic Markers; D006801:Humans; D008126:Lod Score; D008297:Male; D008875:Middle Aged; D008969:Molecular Sequence Data; D010375:Pedigree
D016564:Amyloid beta-Protein Precursor; D005819:Genetic Markers; D004247:DNA