Ultrasound studies of the effect of trospium chloride on gall-bladder kinetics.
In a randomized double-blind study the effects of increasing doses of trospium chloride (Spasmo-lyt, CAS 10405-02-4), 0.2, 0.5, 1.0, and 1.5 mg i.v., on gall-bladder contractility were compared among themselves and against placebo and n-butylscopolamine bromide (20 mg i.v.) by an intraindividual 5-fold crossover technique. Gall-bladder volumes after drug-induced contraction (fat stimulus with sodium iopodate) were measured by ultrasound scanning conducted by a single examiner. Serial measurements, carried out in 6 female subjects without any evidence of gall-bladder disease, demonstrated a dose-dependent trend of inhibition of gall-bladder motility produced by trospium chloride. In the maximal doses employed (1.0 and 1.5 mg i.v.) trospium chloride effected almost total inhibition of motility. The response to n-butylscopolamine bromide tested in a nonblind comparison, showed a dose-effect ratio of roughly 40:1 between trospium chloride and n-butylscopolamine bromide given intravenously. This work confirms that ultrasound measurement of gall-bladder volume is a suitable pharmacodynamic model for testing the dose-effect relationships of antispasmodic agents.
Matzkies
F
F
Kurparkklinik Bad Neustadt/Saale, Fed. Rep. of Germany.
Mürtz
G
G
Giannetti
B
B
Lenhard
G
G
Schicketanz
K H
KH
D001561:Benzilates; D001652:Bile Ducts / Q000000981:diagnostic imaging / Q000187:drug effects; D002086:Butylscopolammonium Bromide / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D004311:Double-Blind Method; D005260:Female; D005704:Gallbladder / Q000000981:diagnostic imaging / Q000187:drug effects*; D006801:Humans; D009126:Muscle Relaxation / Q000187:drug effects; D009662:Nortropanes / Q000009:adverse effects / Q000494:pharmacology*; D010276:Parasympatholytics / Q000009:adverse effects / Q000494:pharmacology*; D014463:Ultrasonography
D001561:Benzilates; D009662:Nortropanes; D010276:Parasympatholytics; C003330:trospium chloride; D002086:Butylscopolammonium Bromide