title: [Clinical observation on efficacy of ivermectin in the treatment of intestinal nematode infections].
abstract: A total of 166 cases were divided into 3 groups: group A comprised 55, group B 54 and group C 57 cases. Group A received ivermectin 0.1 mg/kg orally at a single dose, the cure rates were 100%, 3.8% and 50% for ascaris, hookworm and trichuris, infections respectively: group B received ivermectin 0.2 mg/kg orally at a single dose, the corresponding cure rates were 95.5%, 11.8% and 76.5% respectively; group C received pyrantel pamoate 10 mg/kg orally at a single dose, the corresponding cure rates were 95.5%, 29.6% and 31.6% respectively. Although the cure rates were very low for hookworm infection in both group A and B, however, a number of adult worms of Ancylostoma duodenale and Necator americanus were expelled aster medication; It indicates that ivermectin has some effects on these two species of human hookworm. Side effects were mild and transient in all groups.
authors.affiliation: Institute of Parasitic Diseases, Zhejiang Academy of Medical Sciences, Hangzhou.
authors.forename: Z H
authors.initials: ZH
authors.lastname: Xia
authors.forename: Y L
authors.initials: YL
authors.lastname: Su
authors.forename: S Y
authors.initials: SY
authors.lastname: Yao
authors.forename: B R
authors.initials: BR
authors.lastname: Shen
authors.forename: L Y
authors.initials: LY
authors.lastname: Wen
authors.forename: C C
authors.initials: CC
authors.lastname: Song
authors.forename: Z K
authors.initials: ZK
authors.lastname: Wu
authors.forename: Y C
authors.initials: YC
authors.lastname: Zou
authors.forename: J C
authors.initials: JC
authors.lastname: Meng
authors.forename: H L
authors.initials: HL
authors.lastname: Yang
mesh_terms: D000293:Adolescent; D000328:Adult; D000722:Ancylostoma / Q000187:drug effects; D000818:Animals; D001196:Ascariasis / Q000188:drug therapy; D006725:Hookworm Infections / Q000188:drug therapy; D006801:Humans; D007411:Intestinal Diseases, Parasitic / Q000188:drug therapy*; D007559:Ivermectin / Q000627:therapeutic use*; D017221:Necator americanus / Q000187:drug effects; D009349:Nematode Infections / Q000188:drug therapy*; D011716:Pyrantel Pamoate / Q000627:therapeutic use; D014257:Trichuriasis / Q000188:drug therapy
chemical_list: D007559:Ivermectin; D011716:Pyrantel Pamoate