[The anticoagulant action of a factor from the nondialyzed fraction of the ammoniacal extract of the lungwort, Pulmonaria mollissima].
It has been established that a non-dialyzed fraction of ammoniacal extract from P. molissima contains an anticoagulant-glycopeptide. In in vivo experiments, it produces stable hypocoagulemia, primarily blocking fibrin self-assemblage, and prevents the animal's death from thromboplastinemia. It has been found that the aforesaid action does not exert any adverse effect on the blood contents, arterial pressure, respiration or urinary renal function.
Leven
P I
PI
Dement'eva
I A
IA
Chabanov
M K
MK
D000818:Animals; D000925:Anticoagulants / Q000302:isolation & purification / Q000494:pharmacology* / Q000633:toxicity; D001777:Blood Coagulation / Q000187:drug effects; D001794:Blood Pressure / Q000187:drug effects; D003956:Dialysis; D004305:Dose-Response Relationship, Drug; D005337:Fibrin / Q000187:drug effects; D006020:Glycopeptides / Q000302:isolation & purification / Q000494:pharmacology* / Q000633:toxicity; D010936:Plant Extracts / Q000302:isolation & purification / Q000494:pharmacology* / Q000633:toxicity; D011817:Rabbits; D051381:Rats; D012119:Respiration / Q000187:drug effects; D013997:Time Factors
D000925:Anticoagulants; D006020:Glycopeptides; D010936:Plant Extracts; D005337:Fibrin
Protivosvertyvaiushchee deĭstvie antikoagulianta nedializuemoĭ fraktsii ammiachnogo ékstrakta iz travy medunitsy miagchaĭsheĭ.