title: Langerhans cells and lymphocyte subsets in human gastrointestinal carcinomas. An immunohistological study on frozen sections.
abstract: In an immunohistochemical study of 38 human gastric and 40 human colonic carcinomas Langerhans cells, suppressor and helper lymphocytes were identified on frozen sections by using anti-CD1, anti-CD8 and anti-CD4 monoclonal antibodies. Tumours were divided into those with few (< 3 per high power field) and those with many (> 3 per high power field) Langerhans cells as well as into those with high number of CD4 and CD8 cells (> 30 per high power field). No significant difference in the number of Langerhans cells regarding histologic types, degree of differentiation and metastatic/non-metastatic groups of either gastric or colonic carcinomas was found. On the contrary the numbers of Langerhans cells related significantly (p < 0.05) to density of T-cell and especially CD4 cell infiltrations of gastric and colonic carcinomas. This finding supports the role of Langerhans cells as antigen presenting cells and their involvement in T-cell activation against neoplastic cells of human gastrointestinal carcinomas.
authors.affiliation: Department of Pathology, School of Medicine, Aristotelian University of Thessaloniki, Greece.
authors.forename: C S
authors.initials: CS
authors.lastname: Papadimitriou
authors.forename: G
authors.initials: G
authors.lastname: Datseris
authors.forename: J S
authors.initials: JS
authors.lastname: Costopoulos
authors.forename: M K
authors.initials: MK
authors.lastname: Bai
authors.forename: E
authors.initials: E
authors.lastname: Ioachim-Velogianni
authors.forename: V
authors.initials: V
authors.lastname: Katsouyannopoulos
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000911:Antibodies, Monoclonal; D002277:Carcinoma / Q000737:chemistry / Q000473:pathology*; D015179:Colorectal Neoplasms / Q000737:chemistry / Q000473:pathology*; D005260:Female; D006801:Humans; D007801:Langerhans Cells / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D009418:S100 Proteins / Q000032:analysis; D013274:Stomach Neoplasms / Q000737:chemistry / Q000473:pathology*; D006377:T-Lymphocytes, Helper-Inducer / Q000473:pathology*; D050378:T-Lymphocytes, Regulatory / Q000473:pathology*
chemical_list: D000911:Antibodies, Monoclonal; D009418:S100 Proteins