title: Species differences in platelet aggregation induced by platelet-activating factor (PAF).
abstract: Species differences in platelet aggregation induced by platelet-activating factor (PAF) were investigated by using the same procedure of platelet preparation and biological assay. Washed platelets of six different species (horses, dogs, rats, rabbits, sheep and guinea pigs) were prepared employing the same method and platelet aggregation was induced by C16-PAF. Horse platelets were most sensitive to PAF (8.0 x 10(-12) M) and rabbit platelets activated by 5.0 x 10(-11) M PAF were also sensitive enough to detect PAF in clinical samples.
authors.affiliation: Department of Surgery II, Osaka University Medical School, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Shinozaki
authors.forename: T
authors.initials: T
authors.lastname: Kawasaki
authors.forename: J
authors.initials: J
authors.lastname: Kambayashi
authors.forename: M
authors.initials: M
authors.lastname: Sakon
authors.forename: E
authors.initials: E
authors.lastname: Shiba
authors.forename: M
authors.initials: M
authors.lastname: Ou
authors.forename: T
authors.initials: T
authors.lastname: Mori
mesh_terms: D000818:Animals; D004285:Dogs; D006168:Guinea Pigs; D006736:Horses; D066298:In Vitro Techniques; D008297:Male; D010972:Platelet Activating Factor / Q000494:pharmacology*; D010974:Platelet Aggregation / Q000187:drug effects*; D011817:Rabbits; D051381:Rats; D012756:Sheep; D013045:Species Specificity
chemical_list: D010972:Platelet Activating Factor