[Evolution of the blood levels of propofol administered by continuous perfusion during extracorporeal circulation].
The pharmacokinetics of propofol administered in continuous infusion was studied in 10 patients without left ventricular insufficiency during extracorporeal circulation (ECC) with hemodilution, for aortocoronary bypass. After a dosage of 1.5 mg.kg-1 during anaesthetic induction, the blood level was 4,800 micrograms.l-1. Under continuous infusion levels remained very high: they decreased by 40% during EEC induction and rose more than 10% when artificial ventilation started again. These modifications can be explained by physiological variations induced by EEC (non pulsated flow, redistribution, vasoconstriction, hemodilution, hypothermia) and they lead to adapt dosages in this type of anaesthesia.
Grill
S
S
Anesthésie-Réanimation, Hôpital Broussais, Paris.
Garcia
A
A
Farinotti
R
R
Touzet
M
M
Cousin
M T
MT
D000368:Aged; D005112:Extracorporeal Circulation; D005260:Female; D006801:Humans; D007262:Infusions, Intravenous; D008297:Male; D008875:Middle Aged; D015742:Propofol / Q000008:administration & dosage / Q000097:blood*; D013997:Time Factors
D015742:Propofol
Evolution des niveaux sanguins de propofol administré en perfusion continue au cours de la circulation extracorporelle.