[The biological mechanisms of a congenital predisposition to alcoholism].
In descendants of white rats with chronic alcoholic intoxication, the contents of DA in the brain and blood plasma, characteristics of GABA and opiate brain receptors, the contents of cAMP and other substances were studied as well as the c-fos gene expression. The data obtained suggest a considerable role of the changes in the DA system functions in the genesis of pathology in these descendants.
Anokhina
I P
IP
Vekshina
N L
NL
Kuznetsova
M N
MN
Ovchinnikova
L N
LN
Stanishevskaia
A V
AV
Khristoliubova
N A
NA
Shamakina
I Iu
IIu
D000437:Alcoholism / Q000235:genetics / Q000503:physiopathology*; D000818:Animals; D001921:Brain / Q000187:drug effects / Q000378:metabolism; D001923:Brain Chemistry / Q000187:drug effects; D004198:Disease Susceptibility / Q000151:congenital / Q000503:physiopathology; D000431:Ethanol / Q000494:pharmacology; D005260:Female; D005786:Gene Expression Regulation / Q000187:drug effects / Q000502:physiology; D016762:Genes, fos / Q000187:drug effects / Q000502:physiology; D020022:Genetic Predisposition to Disease; D008297:Male; D051381:Rats
D000431:Ethanol
Nekotorye biologicheskie mekhanizmy vrozhdennoĭ predraspolozhennosti k alkogolizmu.