[The action of dipyridamole on megakaryocytopoiesis in regenerating and stationary bone marrow cell populations].
The effect of dipyridamole on megakaryocytopoiesis in regenerating and stationary populations of mouse bone marrow cells has been studied by heterotopic transplantation of the bone marrow using histological, electron microscopic and biochemical techniques. It is shown that drug administration induced destruction of megakaryocytes. In megakaryocytic cytoplasm giant lipid granules were found whose growth and number increase resulted in megakaryocytes kill. Gas-liquid chromatography was used to evaluate the effect of dipyridamole on distribution of lipid fatty acids of the stationary and regenerating populations of the bone marrow cells. A marked increase of the percentage of docosahexaenoic acid was found in lipids of the stationary population. Chronic dipyridamole administration caused an increase of percentage of myristic, palmitic oleic acids, and decrease of percentage of arachidonic and eicosapentaenoic acids in lipids of regenerating bone marrow cells population.
Ivasenko
I N
IN
Bliudzin
Iu A
IuA
Cherniakova
D N
DN
Almazov
V A
VA
Arkad'eva
G E
GE
D000818:Animals; D001853:Bone Marrow / Q000187:drug effects* / Q000378:metabolism / Q000648:ultrastructure; D016026:Bone Marrow Transplantation / Q000502:physiology; D004176:Dipyridamole / Q000494:pharmacology*; D005227:Fatty Acids / Q000378:metabolism; D007668:Kidney; D008297:Male; D008533:Megakaryocytes / Q000187:drug effects* / Q000378:metabolism / Q000648:ultrastructure; D051379:Mice; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D008854:Microscopy, Electron; D012038:Regeneration / Q000187:drug effects* / Q000502:physiology; D013997:Time Factors; D016042:Transplantation, Heterotopic
D005227:Fatty Acids; D004176:Dipyridamole
Deĭstvie dipiridamola na megakariotsitopoéz v regeneriruiushcheĭ i statsionarnoĭ populiatsiiakh kletok kostnogo mozga.