Effect of tubocurarine on the central generator of embryonic spontaneous motility.
The continuous administration of d-tubocurarine (6.5 +/- 0.4 mg/kg e.w./24 h) to chick embryos from the 4th to the 12th day of incubation had a positive effect on defects produced in the development of spontaneous motility either by decentralization of the spinal cord or by chemical phenobarbital depression, or by a combination of both experimental factors. In normal embryos, d-tubocurarine had no effect on the development of spontaneous motility.
Sedlácek
J
J
Institute of Physiology, Faculty of Medicine, Charles University, Prague.
D000818:Animals; D002642:Chick Embryo / Q000502:physiology*; D009068:Movement / Q000187:drug effects*; D009924:Organ Culture Techniques; D010634:Phenobarbital; D014403:Tubocurarine / Q000494:pharmacology*
D014403:Tubocurarine; D010634:Phenobarbital