[The anticarcinogenic effects of fumaric acid on models of carcinogenesis in the esophagus, nervous system and kidney].
Anticarcinogenic effects of the fumaric acid was studied in two rat models of carcinogenesis. Tumors of the esophagus, forestomach, tongue and throat were induced by peroral instillation of 35 mg/kg body weight N-methyl-N-benzylnitrosamine, and neurogenic and renal ones--by transplacental injection of 75 mg/kg body weight N-ethyl-N-nitrosourea. The fumaric acid given in drinking water in the dose of 1 g/l at the postinitiation stage of the carcinogenesis was shown to inhibit the development of esophageal papilloma, brain glioma and mesenchymal tumors of the kidney.
Bespalov
V G
VG
Aleksandrov
V A
VA
Petrov
A S
AS
Troian
D N
DN
D000818:Animals; D016588:Anticarcinogenic Agents / Q000627:therapeutic use*; D002273:Carcinogens; D016009:Chi-Square Distribution; D004128:Dimethylnitrosamine / Q000031:analogs & derivatives; D004195:Disease Models, Animal; D004354:Drug Screening Assays, Antitumor; D004938:Esophageal Neoplasms / Q000139:chemically induced / Q000453:epidemiology / Q000517:prevention & control*; D005038:Ethylnitrosourea; D005260:Female; D005650:Fumarates / Q000627:therapeutic use*; D007680:Kidney Neoplasms / Q000139:chemically induced / Q000453:epidemiology / Q000517:prevention & control*; D008297:Male; D009423:Nervous System Neoplasms / Q000139:chemically induced / Q000453:epidemiology / Q000517:prevention & control*; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects; D051381:Rats
D016588:Anticarcinogenic Agents; D002273:Carcinogens; D005650:Fumarates; C032005:fumaric acid; C014707:nitrosobenzylmethylamine; D004128:Dimethylnitrosamine; D005038:Ethylnitrosourea
Izuchenie antikantserogennykh éffektov fumarovoĭ kisloty na modeliakh kantserogeneza v pishchevode, nervnoĭ sisteme i pochke.