[The results of the therapeutic monitoring of piracetam in parturients and newborn infants].
Overall 30 women in childbirth with preeclampsia and fetoplacental dysfunction received piracetam solution which was given initially in a dose of 5 g by intravenous drip, rapidly since the onset of labour and then every 2 hours till the end of labour in a dose of 2 g by jet injection. This made it possible to increase fetus resistance to hypoxic conditions. The concentrations of piracetam within the range of 60-80 g/l in the blood of women in childbirth should be viewed as minimum therapeutic. A single daily intramuscular injection of piracetam (50 mg/kg) into neonates with encephalopathies may build up blood concentrations equal to 25-60 mg/l after 2 hours. The drug is not detectable in the blood by the moment the next injection is given.
Sirotina
I V
IV
Aleksandrova
Z D
ZD
Bogatyreva
N V
NV
Gusel'
V A
VA
Smirnov
D P
DP
Khodov
D A
DA
Grandilevskaia
O L
OL
D000293:Adolescent; D000328:Adult; D001238:Asphyxia Neonatorum / Q000097:blood / Q000517:prevention & control; D002851:Chromatography, High Pressure Liquid; D002908:Chronic Disease; D016903:Drug Monitoring; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D007743:Labor, Obstetric / Q000097:blood / Q000187:drug effects*; D010889:Piracetam / Q000008:administration & dosage / Q000097:blood*; D010927:Placental Insufficiency / Q000097:blood / Q000188:drug therapy; D011225:Pre-Eclampsia / Q000097:blood / Q000188:drug therapy; D011247:Pregnancy
D010889:Piracetam
Rezul'taty terapevticheskogo monitoringa piratsetama u rozhenits i novorozhdennykh deteĭ.