Anti-infectious effect of C granulosum-derived P40 immunomodulator given by aerosolization and intranasal instillation.
It is known that C granulosum-derived P40 immunomodulator displays strong anti-microbial effects in mice by the intravenous route. Since microbial contamination of humans occurs in many instances via the airways, the effect of P40 on infections was investigated when it was given intranasally or by aerosolization. In order to augment its bioavailability, P40 was derivatized by coupling with polylysine chains (P40-PL). The results showed that P40-PL exercised a significant protective effect, both by the intranasal route and by aerosolization on both influenza and K pneumoniae infections produced by aerosolization or intranasal instillation. Stimulation of the phagocytic capacity of alveolar macrophages by these types of treatment is likely to account for the increased resistance of mice toward microbial infections.
Bizzini
B
B
Unité de Toxinologie Moléculaire, Institut Pasteur, Paris, France.
Carlotti
M
M
Fattal German
M
M
D000276:Adjuvants, Immunologic / Q000008:administration & dosage* / Q000302:isolation & purification / Q000494:pharmacology*; D000280:Administration, Inhalation; D000281:Administration, Intranasal; D000818:Animals; D003352:Corynebacterium / Q000187:drug effects*; D005260:Female; D007711:Klebsiella pneumoniae / Q000187:drug effects*; D051379:Mice; D009975:Orthomyxoviridae / Q000187:drug effects*
D000276:Adjuvants, Immunologic