[Renal effects of the acute inhibition of angiotensin-converting enzyme. I. 1) Studies during normal sodium and potassium balance].
We have investigated the effective role of angiotensin II on the renal function and urinary excretion of some prostanoids in healthy women submitted to different conditions of potassium balance. To this aim we have evaluated the effects of an acute inhibition of angiotensin converting enzyme by enalapril (E). The renal function was explored by clearance (cl.) method during induced hypotonic polyuria (oral water load followed by 5% dextrose solution infusion). During 60 min cl. period the urinary PGE2, 6-keto-PGF1 alpha and TxB2 were determined by RIA method. Each subject received paired studies, in absence and presence of E (10 mg administered per os 1 hour before the water load). Basal values of plasma renin activity (PRA) and urinary aldosterone (excreted during the 24 hours before the water load) were also determined by RIA method. This study protocol was applied in normal potassium balance (n = 6) and induced moderate potassium depletion (n = 6). This paper concerns the group in normal potassium balance in both absence (N3) and presence of E (N3.E). All subjects were submitted to normal dietary intake of sodium (150 mmol/d) and potassium (50 mmol/d). The basal values of PRA, urinary aldosterone and plasma electrolytes were in the normal range. The only significant effect produced by E was a reduction in mean arterial pressure, without significant changes in creatinine cl., urinary hydro-electrolyte excretions as well as urinary excretions of prostanoids.(ABSTRACT TRUNCATED AT 250 WORDS)
Agnoli
G C
GC
Cattedra di Medicina Interna I, Università di Bologna.
Borgatti
R
R
Cacciari
M
M
Ikonomu
E
E
Lenzi
P
P
Marinelli
M
M
Martello
M
M
D000450:Aldosterone / Q000097:blood; D000804:Angiotensin II / Q000502:physiology*; D001794:Blood Pressure / Q000187:drug effects; D004231:Diuresis / Q000187:drug effects; D004656:Enalapril / Q000494:pharmacology*; D005260:Female; D006706:Homeostasis; D006801:Humans; D007668:Kidney / Q000187:drug effects* / Q000502:physiology; D017419:Potassium, Dietary / Q000494:pharmacology*; D011453:Prostaglandins / Q000652:urine; D012083:Renin / Q000097:blood; D012084:Renin-Angiotensin System / Q000187:drug effects / Q000502:physiology; D012982:Sodium, Dietary / Q000494:pharmacology*; D014882:Water-Electrolyte Balance
D017419:Potassium, Dietary; D011453:Prostaglandins; D012982:Sodium, Dietary; D000804:Angiotensin II; D000450:Aldosterone; D004656:Enalapril; D012083:Renin
Effetti renali della inibizione acuta dell'enzima convertente l'angiotensina. I. 1). Studi in bilancio sodico e potassico normale.