title: MHC associations of autoantibodies against recombinant Ro and La proteins in systemic lupus erythematosus. Results of a multicenter study. SLE Study Group.
abstract: Antibodies against recombinant 52 kD-Ro, recombinant 60 kD-Ro and recombinant La protein were determined by ELISA in over 300 central European patients with systemic lupus erythematosus (SLE). A strong association with HLA-DR3 was found for antibodies against 52 kD-Ro and La, but not for recombinant 60 kD-Ro antibodies in the absence of antibodies against 52 kD-Ro or La. Ro/La negative SLE patients still showed an increased frequency of HLA-DR3 as compared to healthy controls. These results indicated that the preferential formation of Ro and La antibodies was not due to an unspecific stimulatory effect of HLA-DR3 but that the antibody response to certain defined proteins (52 kD-Ro and La) was influenced by MHC genes in SLE. Furthermore, the association of SLE with HLA-DR3 was independent of the effects of DR3 on the formation of 52 kD-Ro and La antibodies.
authors.affiliation: Department of Medicine, University of Hannover, Federal Republic of Germany.
authors.forename: H
authors.initials: H
authors.lastname: Ehrfeld
authors.forename: K
authors.initials: K
authors.lastname: Hartung
authors.forename: M
authors.initials: M
authors.lastname: Renz
authors.forename: R
authors.initials: R
authors.lastname: Coldewey
authors.forename: H
authors.initials: H
authors.lastname: Deicher
authors.forename: M
authors.initials: M
authors.lastname: Fricke
authors.forename: J R
authors.initials: JR
authors.lastname: Kalden
authors.forename: J
authors.initials: J
authors.lastname: Lakomek
authors.forename: H H
authors.initials: HH
authors.lastname: Peter
authors.forename: D
authors.initials: D
authors.lastname: Schendel
mesh_terms: D000918:Antibody Specificity; D001323:Autoantibodies / Q000276:immunology*; D001324:Autoantigens / Q000276:immunology*; D003378:Counterimmunoelectrophoresis; D004797:Enzyme-Linked Immunosorbent Assay; D006680:HLA Antigens / Q000276:immunology*; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000276:immunology*; D016017:Odds Ratio; D020733:RNA, Small Cytoplasmic; D011994:Recombinant Proteins; D012261:Ribonucleoproteins / Q000276:immunology*; D000097585:SS-B Antigen; D000099207:SS-A Antigen
chemical_list: D001323:Autoantibodies; D001324:Autoantigens; D006680:HLA Antigens; D020733:RNA, Small Cytoplasmic; D011994:Recombinant Proteins; D012261:Ribonucleoproteins; D000097585:SS-B Antigen; D000099207:SS-A Antigen; C116006:RO60 protein, human