title: Combined radiation and chemotherapy for epidermoid carcinoma of the anal canal.
abstract: Between 1985 and 1992, 46 patients with epidermoid carcinoma of the anal canal were treated prospectively by a protocol of combined radiation and chemotherapy with 5-Fluorouracil and Mitomycin C. The survival rate, NED-survival rate and local tumour control rate were 84%, 71% and 83% at 5 years. Anorectal function was retained in 33 of 41 patients (80%). We observed severe acute toxicity including three deaths, but very little late morbidity. The only marginally significant prognostic factor (P = 0.06) for local tumour control was T-stage. NED-survival was significantly affected (P = 0.02) by reduction of chemotherapy during the second course.
authors.affiliation: Department of Surgery, University Hospital of Erlangen, Federal Republic of Germany.
authors.forename: I H
authors.initials: IH
authors.lastname: Schneider
authors.forename: G G
authors.initials: GG
authors.lastname: Grabenbauer
authors.forename: T
authors.initials: T
authors.lastname: Reck
authors.forename: F
authors.initials: F
authors.lastname: Köckerling
authors.forename: R
authors.initials: R
authors.lastname: Sauer
authors.forename: F P
authors.initials: FP
authors.lastname: Gall
mesh_terms: D000328:Adult; D000368:Aged; D001005:Anus Neoplasms / Q000188:drug therapy* / Q000401:mortality / Q000532:radiotherapy*; D002294:Carcinoma, Squamous Cell / Q000188:drug therapy* / Q000401:mortality / Q000532:radiotherapy*; D003131:Combined Modality Therapy; D005260:Female; D005472:Fluorouracil / Q000008:administration & dosage / Q000627:therapeutic use; D006801:Humans; D007262:Infusions, Intravenous; D008297:Male; D008875:Middle Aged; D008937:Mitomycins / Q000008:administration & dosage / Q000627:therapeutic use; D015996:Survival Rate
chemical_list: D008937:Mitomycins; D005472:Fluorouracil