[The selective accumulation of monoclonal antibodies in the lungs after cyclophosphane administration to rats].
The study has demonstrated the possibility to use cyclophosphamide as a model of "impairment" agent for lung tissue cells to provide access of monoclonal antibodies to nuclear antigen structures. Biodistribution of monoclonal antibodies to various intracellular antigens was studied on Wistar rats pretreated with various doses of cyclophosphamide. Accumulation of 2C5 antibodies to cell nuclei was found to be dependent on the dose of cyclophosphamide administered.
Torchilin
V P
VP
Mukhamedova
N M
NM
Il'ina
A I
AI
Iakubov
L Z
LZ
Shchitkov
K G
KG
D000818:Animals; D000911:Antibodies, Monoclonal / Q000187:drug effects* / Q000378:metabolism; D003520:Cyclophosphamide / Q000008:administration & dosage*; D004305:Dose-Response Relationship, Drug; D007457:Iodine Radioisotopes; D008168:Lung / Q000187:drug effects* / Q000378:metabolism; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D014018:Tissue Distribution / Q000187:drug effects
D000911:Antibodies, Monoclonal; D007457:Iodine Radioisotopes; D003520:Cyclophosphamide
Izbiratel'noe nakoplenie monoklonal'nykh antitel v legkikh posle vvedeniia krysam tsiklofosfana.