Efficacy of albendazole against Trichinella pseudospiralis and Trichinella spiralis in mice.
Albendazole (Smith Kline, Beecham) in a dose of 20 mg/kg/day was given to B6C3F1 mice exposed to 300 larvae of T. pseudospiralis or T. spiralis. The drug was introduced on days 2, 3 and 4; or 4, 5 and 6; or 18, 19 and 20 after infection. It limited the intensity of intestinal and muscle phases of trichinellosis. Given at the stage of maturation of adult forms and production of new-born larvae, the drug caused almost total elimination of both species from the intestines of mice and a decrease in the numbers of muscle larvae, with a tendency towards a greater reduction of larvae and adults of T. pseudospiralis. The drug did not change the course of infection when given at the phase of infectivity of larvae.
Bany
J
J
Dept. of Parasitology, Military Institute of Hygiene and Epidemiology, Warsaw.
Lach
J
J
Golińska
Z
Z
D015766:Albendazole / Q000627:therapeutic use*; D000818:Animals; D007411:Intestinal Diseases, Parasitic / Q000188:drug therapy; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D009132:Muscles / Q000187:drug effects / Q000469:parasitology; D017160:Trichinella spiralis; D014235:Trichinellosis / Q000188:drug therapy*
D015766:Albendazole