[Alcohol decreases the alpha subunit, LH and testosterone secretion in response to LH-RH].
In our previous study we showed that alcohol disturbed the circadian rhythms of LH, testosterone and its conversion to DHT. To determine the effect of LH-RH on pituitary-gonadal function before and after alcohol, 11 male volunteers aged 24-29 years (mean 25.5) were investigated. Blood for hormonal estimations was withdrawn before and 20, 30, 60, and 120 min after LH-RH. In every case, the LH-RH test was performed twice: 6 hours after placebo and, a week later, 6 hours after alcohol administered orally, in dose of 1.0 g/kg bw. The LH, FSH, alpha-subunit and testosterone concentrations were measured with radioimmunological methods.


RESULTS
It was shown that alcohol significantly inhibited LH (p < 0.05), alpha-subunit (p < 0.02) and testosterone (p < 0.001) response to LH-RH stimulation, but not that of FSH.
Zgliczyński
W
W
Klinika Endokrynologii Centrum Medycznego Kształcenia Podyplomowego, Warszawie.
Nowakowski
J
J
Rosłonowska
E
E
Jeske
W
W
Snochowska
H
H
Zgliczyński
S
S
D000328:Adult; D000431:Ethanol / Q000494:pharmacology*; D015292:Glycoprotein Hormones, alpha Subunit / Q000378:metabolism*; D007987:Gonadotropin-Releasing Hormone / Q000502:physiology*; D006801:Humans; D007986:Luteinizing Hormone / Q000378:metabolism*; D008297:Male; D011863:Radioimmunoassay; D013739:Testosterone / Q000378:metabolism*
D015292:Glycoprotein Hormones, alpha Subunit; D007987:Gonadotropin-Releasing Hormone; D000431:Ethanol; D013739:Testosterone; D007986:Luteinizing Hormone
Alkohol zmniejsza wydzielanie alpha-podjednostek, LHI testosteronu w odpowiedzi na LH-RH.