Extra pyramidal side effects associated with paroxetine.
A 29-year-old man admitted to a psychiatric unit was successfully treated for a paranoid psychosis with trifluoperazine. Following reduction of neuroleptic dosage and addition of paroxetine he developed severe extra-pyramidal side effects. These remitted after withdrawal of medication and did not recur following recommencement of trifluoperazine. This is the first report of such a side effect associated with paroxetine use in man.
Nicholson
S D
SD
Psychiatric Department, North Devon District Hospital, Raleigh Park.
D000328:Adult; D001480:Basal Ganglia Diseases / Q000139:chemically induced*; D004359:Drug Therapy, Combination; D006801:Humans; D008297:Male; D010259:Paranoid Disorders / Q000188:drug therapy; D017374:Paroxetine / Q000009:adverse effects* / Q000627:therapeutic use; D014268:Trifluoperazine / Q000627:therapeutic use
D014268:Trifluoperazine; D017374:Paroxetine