title: Thermal effect of glucose in women with normal carbohydrate tolerance: relationship to body mass index, blood insulin and noradrenaline.
abstract: Relationships between energy expenditure, body mass index (BMI), blood glucose (BG) responses to glucose ingestion were studied in 35 women aged 22-55 yrs with normal carbohydrate tolerance. In 13 of them plasma insulin (IRI) and catecholamine concentrations were also determined. Thirty seven per cent of patients did not respond to glucose load with an increased energy expenditure. In the remaining women the average thermogenic effect amounted to approx. 10% of their initial metabolic rate. A significant negative correlation (r = -0.415, n = 35, P(0.02) was found between BMI and the overall thermal effect of glucose (sigma TEG) calculated as a sum of the post-glucose energy expenditure measured every 15 min during 2 h minus the baseline value. Neither the fasting nor the post glucose BG concentrations correlated with sigma TEG. Significant correlations were ascertained between sigma TEG and the fasting IRI (r = -0.568), the sigma post-glucose IRI (r = -0.723), the ratio of sigma BG/sigma IRI (r = 0.845) and the post-glucose plasma noradrenaline concentration (r = 0.837).
  
  
  CONCLUSIONS
  in women with normal carbohydrate tolerance the thermogenic effect of glucose depends to a large extent on insulin sensitivity and the glucose-induced activation of the sympathetic nervous system.
authors.affiliation: Department of Applied Physiology, Medical Centre, Polish Academy of Sciences, Warszawa.
authors.forename: A
authors.initials: A
authors.lastname: Ziemba
authors.forename: K
authors.initials: K
authors.lastname: Nazar
authors.forename: H
authors.initials: H
authors.lastname: Kaciuba-Uściłko
authors.forename: B
authors.initials: B
authors.lastname: Bicz
authors.forename: E
authors.initials: E
authors.lastname: Titow-Stupnicka
mesh_terms: D000328:Adult; D001786:Blood Glucose / Q000378:metabolism*; D015992:Body Mass Index; D050260:Carbohydrate Metabolism; D004734:Energy Metabolism / Q000502:physiology*; D005260:Female; D005951:Glucose Tolerance Test; D006801:Humans; D007328:Insulin / Q000097:blood*; D008875:Middle Aged; D009638:Norepinephrine / Q000097:blood*; D012016:Reference Values
chemical_list: D001786:Blood Glucose; D007328:Insulin; D009638:Norepinephrine