Location of the granulocyte-specific antigen LAN on the Fc-receptor III.
This report investigates the location of the binding site of a recently described granulocyte-specific alloantibody, designated LAN, which causes alloimmune neonatal neutropenia. The LAN antigen is shown to be situated on the Fc-receptor III (FcRIII).
Metcalfe
P
P
Department of Haematology, St Bartholomew's Hospital and Medical College, London, U.K.
Waters
A H
AH
D000328:Adult; D000918:Antibody Specificity; D000939:Epitopes / Q000276:immunology*; D005260:Female; D005455:Fluorescent Antibody Technique; D006098:Granulocytes / Q000276:immunology*; D006457:Hemoglobinuria, Paroxysmal / Q000276:immunology; D006801:Humans; D007124:Immunoenzyme Techniques; D007074:Immunoglobulin G / Q000276:immunology*; D007163:Immunosorbent Techniques; D007518:Isoantibodies / Q000276:immunology*; D007519:Isoantigens / Q000032:analysis* / Q000276:immunology; D017452:Receptors, IgG / Q000276:immunology*
D000939:Epitopes; D007074:Immunoglobulin G; D007518:Isoantibodies; D007519:Isoantigens; C083301:LAN antigen; D017452:Receptors, IgG