Double monoclonal cryoglobulinemia, glomerulonephritis and lymphoma.
We present a case of monoclonal cryoglobulinemia with double monoclonal component IgA lambda-IgG lambda, without complement activation, membranoproliferative glomerulonephritis (MPGN) with deposits of IgA, IgG and lambda chains and lymphocytic IgA-lambda-chain-secreting lymphoma. This case emphasizes the possibility that double monoclonal cryoglobulins could behave differently compared to type I cryoglobulins, determining a MPGN-like type II cryoglobulins do, but without activating the complement cascade.
Rollino
C
C
Service de Néphrologie, Centre Hospitalier Universitaire, Grenoble, France.
Dieny
A
A
Le Marc'hadour
F
F
Renversez
J C
JC
Pinel
N
N
Cordonnier
D
D
D015703:Antigens, CD / Q000032:analysis; D000951:Antigens, Neoplasm / Q000276:immunology; D002999:Clone Cells; D003449:Cryoglobulinemia / Q000150:complications*; D015322:Gene Rearrangement, B-Lymphocyte; D015432:Glomerulonephritis, Membranoproliferative / Q000209:etiology* / Q000276:immunology / Q000473:pathology; D006801:Humans; D008223:Lymphoma / Q000150:complications* / Q000276:immunology / Q000473:pathology; D008297:Male; D008875:Middle Aged; D013154:Spleen / Q000473:pathology
D015703:Antigens, CD; D000951:Antigens, Neoplasm