Is Yq11 the main critical segment in balanced Y;autosome translocations?
Balanced Y;Autosome translocations seem to be associated with male infertility whenever the Y breakpoint is located into Yq11 (where the azoospermia factor maps) or near its boundaries. By analogy with the effect on female carriers' fertility of balanced X;Autosome translocations, the band Yq11 emerges as the critical segment. This hypothesis implies that the subjacent mechanism is an impaired expression of the azoospermia factor--either through its physical disruption or via a position effect--rather than a disorder of the sex bivalent inactivation during prophase I.
Rivera
H
H
División de Genética, Instituto Mexicano del Seguro Social, Guadalajara, Jalisco.
Diaz-Castaños
L
L
D006801:Humans; D007248:Infertility, Male / Q000235:genetics*; D008297:Male; D008957:Models, Genetic; D014178:Translocation, Genetic; D014998:Y Chromosome / Q000648:ultrastructure*