title: Human leukocyte A and B antigen, gene and haplotype frequencies in the population of the city of São Paulo in Brazil.
abstract: 1. Antigen, gene and haplotype frequencies are important data for population analysis, paternity exclusion testing, genetic studies, and for organ transplantation selection. 2. We have studied the Class I histocompatibility antigens of 617 unrelated individuals from the city of São Paulo, Brazil, to determine antigen and gene frequencies of 16 HLA-A and 28 HLA-B antigens. Estimated haplotype frequencies were also determined, as well as the genetic distances of this population from European Caucasian and Negro populations. 3. A previously unknown linkage disequilibrium was detected for A23-B49 and a clear trend towards antigen frequencies intermediate between Caucasoid and Negro populations was observed.
authors.affiliation: Laboratório de Imunologia de Transplantes, Hospital das Clínicas da Faculdade de Medicina, Universidade de São Paulo, Brasil.
authors.forename: T
authors.initials: T
authors.lastname: Rosales
authors.forename: L
authors.initials: L
authors.lastname: Guilherme
authors.forename: J
authors.initials: J
authors.lastname: Chiarella
authors.forename: M L
authors.initials: ML
authors.lastname: Marin
authors.forename: C
authors.initials: C
authors.lastname: Rosales
authors.forename: C P
authors.initials: CP
authors.lastname: Melo
authors.forename: A C
authors.initials: AC
authors.lastname: Goldberg
authors.forename: J
authors.initials: J
authors.lastname: Kalil
mesh_terms: D000328:Adult; D015703:Antigens, CD; D044383:Black People / Q000235:genetics; D001938:Brazil; D005787:Gene Frequency; D008040:Genetic Linkage; D015234:HLA-A Antigens / Q000235:genetics*; D015235:HLA-B Antigens / Q000235:genetics*; D006239:Haplotypes / Q000235:genetics*; D006801:Humans; D044465:White People / Q000235:genetics
chemical_list: D015703:Antigens, CD; D015234:HLA-A Antigens; D015235:HLA-B Antigens