title: Comparison of artemisinin suppositories with intravenous artesunate and intravenous quinine in the treatment of cerebral malaria.
abstract: Seventy-nine comatose cerebral malaria patients given standard supportive treatment were randomized to receive specific antimalarial chemotherapy of intravenous quinine, intravenous artesunate, or artemisinin suppositories. Artesunate and artemisinin reduced peripheral asexual parasitaemia significantly more rapidly than quinine (90% clearance time 16 h, 18.9 h and 34.5 h respectively), but did not significantly reduce the duration of coma or mortality. The rapid lowering of peripheral parasitaemia may not ameliorate complications already present. These results demonstrate that artemisinin suppositories are as effective as artesunate and quinine given intravenously, and have economic and practical advantages for the treatment of severe malaria in areas remote from major medical centres. However, large numbers of patients will need to be studied if differences in mortality between the 3 treatment groups are to be demonstrated.
authors.affiliation: Intensive Care Unit, Centre for Tropical Diseases, Ho Chi Minh City, Vietnam.
authors.forename: T T
authors.initials: TT
authors.lastname: Hien
authors.forename: K
authors.initials: K
authors.lastname: Arnold
authors.forename: H
authors.initials: H
authors.lastname: Vinh
authors.forename: B M
authors.initials: BM
authors.lastname: Cuong
authors.forename: N H
authors.initials: NH
authors.lastname: Phu
authors.forename: T T
authors.initials: TT
authors.lastname: Chau
authors.forename: N T
authors.initials: NT
authors.lastname: Hoa
authors.forename: L V
authors.initials: LV
authors.lastname: Chuong
authors.forename: N T
authors.initials: NT
authors.lastname: Mai
authors.forename: N N
authors.initials: NN
authors.lastname: Vinh
mesh_terms: D000293:Adolescent; D000328:Adult; D000818:Animals; D000962:Antimalarials / Q000008:administration & dosage*; D037621:Artemisinins; D000077332:Artesunate; D005260:Female; D006801:Humans; D007275:Injections, Intravenous; D016779:Malaria, Cerebral / Q000188:drug therapy* / Q000469:parasitology; D008297:Male; D008875:Middle Aged; D010963:Plasmodium falciparum; D011803:Quinine / Q000008:administration & dosage*; D012717:Sesquiterpenes / Q000008:administration & dosage*; D013488:Suppositories
chemical_list: D000962:Antimalarials; D037621:Artemisinins; D012717:Sesquiterpenes; D013488:Suppositories; D000077332:Artesunate; C031327:artemisinin; D011803:Quinine