Chromosome mapping of Soa, a gene influencing gustatory sensitivity to sucrose octaacetate in mice.
Strain distribution patterns among recombinant inbred strains suggested that a locus influencing taste sensitivity to sucrose octaacetate was on chromosome 6. A location for Soa was established by linkage analysis of behavioral and electrophoretic data from outbred and congenic strains and from test-cross progeny. Haplotyping of 41 outbred CFW-Cr animals with a cDNA probe showed perfect cosegregation of Soa and Prp, a gene for salivary proline-rich proteins. Five of twelve B6.SW-Soaa strains were found to retain Ldr-1, lactate dehydrogenase regulator-1, on chromosome 6 as an allelic passenger from the SWR/J donor strain (source of the Soaa Taster allele). Centimorgan distance was estimated using the ABP/Le linkage-testing strain (non-Taster, Soab) and the SWR/J strain (Taster, Soaa) in a testcross breeding system. The data are consistent with a position for the Soa locus on mouse chromosome 6, 62 cM from the centromere.
Capeless
C G
CG
Department of Psychology, Florida State University, Tallahassee 32306-1051.
Whitney
G
G
Azen
E A
EA
D000818:Animals; D002874:Chromosome Mapping; D003433:Crosses, Genetic; D005260:Female; D008040:Genetic Linkage / Q000235:genetics; D005819:Genetic Markers / Q000235:genetics; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains / Q000235:genetics*; D008957:Models, Genetic; D010641:Phenotype; D011995:Recombination, Genetic / Q000235:genetics*; D013395:Sucrose / Q000031:analogs & derivatives*; D013649:Taste / Q000235:genetics*; D013652:Taste Threshold / Q000502:physiology
D005819:Genetic Markers; C026879:sucrose octaacetate; D013395:Sucrose