title: Spontaneous brain and spinal cord/nerve neoplasms in aged Sprague-Dawley rats.
abstract: Primary malignant neoplasms of the brain and spinal cord occurred in 20/718 male (2.8%) and in 13/717 female (1.8%) Crl:CD Br strain Sprague-Dawley rats. Of 33 neoplasms, 30 were found in brain while 3 were in the spinal cord. In males and females, the most common brain neoplasm was astrocytoma (13 males, 9 females). Other neoplasms, granular cell tumor (1 male), mixed glioma (2 males, 1 female), reticulosis (1 male, 2 females), and oligodendroglioma (2 males), were especially uncommon. Spinal cord neoplasms included 2 schwannomas (1 male, 1 female) and an astrocytoma (1 male). The overall brain neoplasm incidence was similar for males (2.8%) compared to data compiled for this strain, and there was a 2-fold increase for females (1.8% vs 0.9%) compared to available incidence data.
authors.affiliation: Marion Merrell Dow Inc., Indianapolis, Indiana 46268-0470.
authors.forename: G M
authors.initials: GM
authors.lastname: Zwicker
authors.forename: R C
authors.initials: RC
authors.lastname: Eyster
authors.forename: D M
authors.initials: DM
authors.lastname: Sells
authors.forename: J H
authors.initials: JH
authors.lastname: Gass
mesh_terms: D000375:Aging / Q000502:physiology*; D000818:Animals; D001254:Astrocytoma / Q000209:etiology / Q000473:pathology; D001932:Brain Neoplasms / Q000209:etiology* / Q000473:pathology; D005260:Female; D005910:Glioma / Q000209:etiology / Q000473:pathology; D016586:Granular Cell Tumor / Q000209:etiology / Q000473:pathology; D008206:Lymphatic Diseases / Q000209:etiology / Q000473:pathology; D008297:Male; D009442:Neurilemmoma / Q000209:etiology / Q000473:pathology; D009837:Oligodendroglioma / Q000209:etiology / Q000473:pathology; D051381:Rats; D017207:Rats, Sprague-Dawley; D013120:Spinal Cord Neoplasms / Q000209:etiology* / Q000473:pathology