Immunological factors in infertility.
Immune infertility can result from destruction of gametes by antisperm antibodies (ASA) or anti-ovary antibodies, by inhibition of sperm-zona pellucida binding by ASA, or by prevention of embryo cleavage and early development. Condoms, immunosuppressive therapy, sperm processing, and intrauterine insemination have been widely applied, but with controversial results.
Shushan
A
A
Department of Obstetrics and Gynecology, Hebrew University-Hadassah Medical Center, Ein-Karem, Jerusalem, Israel.
Schenker
J G
JG
D001323:Autoantibodies / Q000276:immunology*; D002970:Cleavage Stage, Ovum / Q000276:immunology; D010064:Embryo Implantation; D005314:Embryonic and Fetal Development; D005260:Female; D006801:Humans; D007246:Infertility / Q000276:immunology* / Q000628:therapy; D007518:Isoantibodies / Q000276:immunology*; D008297:Male; D010053:Ovary / Q000276:immunology; D011247:Pregnancy; D012099:Reproductive Techniques; D013084:Sperm-Ovum Interactions; D013094:Spermatozoa / Q000276:immunology
D001323:Autoantibodies; D007518:Isoantibodies