Atherosclerosis from a viewpoint of arterial wall cell function: relation to vitamin E.
Vitamin E affects many key events in atheromatous lesions. Inhibition of EC injury and platelet aggregation was already reported. Foam cell formation must be inhibited according to the data presented by us and other speakers. However, effects on cell proliferation of SMC are paradoxical. The in vivo effects will be dependent on the effective concentration of vitamin E in the loci.
Morisaki
N
N
Second Department of Internal Medicine, School of Medicine, Chiba University, Japan.
Yokote
K
K
Saito
Y
Y
D000818:Animals; D001158:Arteries; D001161:Arteriosclerosis / Q000378:metabolism / Q000517:prevention & control*; D002448:Cell Adhesion / Q000187:drug effects; D004730:Endothelium, Vascular / Q000187:drug effects* / Q000201:enzymology / Q000378:metabolism; D016166:Free Radical Scavengers; D008297:Male; D009000:Monocytes / Q000166:cytology; D009131:Muscle, Smooth, Vascular / Q000166:cytology / Q000187:drug effects; D051381:Rats; D017208:Rats, Wistar; D002787:Sterol Esterase / Q000187:drug effects; D014810:Vitamin E / Q000494:pharmacology*; D014811:Vitamin E Deficiency / Q000378:metabolism
D016166:Free Radical Scavengers; D014810:Vitamin E; D002787:Sterol Esterase