[The effect of obzidan and isobarin on the lysosomal apparatus of the neutrophilic granulocytes and on hemostasis under stress factors].
Experiments on rabbits were carried out with the purpose of evaluating the participation of beta-adreno-blockader and sympatholytic agent in the reaction of liberation of lysosomal enzymes of peripheral blood neutrophilic granulocytes in response to the immobilization. It was established that the sympathetic nervous system (via alpha- and beta adrenoreceptors) produces an effect on reduction of the number of lysosomes and liberation of lysosomal enzymes that participate indirectly through factor XII in hemostasis regulation.
Lunina
N V
NV
Vovk
S V
SV
D000818:Animals; D004353:Drug Evaluation, Preclinical; D005260:Female; D006145:Guanethidine / Q000627:therapeutic use*; D006487:Hemostasis / Q000187:drug effects*; D008247:Lysosomes / Q000187:drug effects* / Q000201:enzymology; D008297:Male; D009504:Neutrophils / Q000187:drug effects* / Q000201:enzymology; D011433:Propranolol / Q000627:therapeutic use*; D011817:Rabbits; D012149:Restraint, Physical; D013315:Stress, Psychological / Q000097:blood / Q000188:drug therapy*
D011433:Propranolol; D006145:Guanethidine
Vplyv obzydanu ta izobarynu na lizosomal'nyĭ aparat neĭtrofil'nykh hranulotsytiv i hemostaz pry stres-faktori.