[Late changes in renal function after lead poisoning and chelation therapy].
Glomerular filtration rate was examined by determination of creatinine clearance in 22 adult males with a past history of lead poisoning. Eighteen subjects had been poisoned after many years of occupational exposure to lead and four had been poisoned by ingestion of alcohol beverage kept in lead-glazed pots. Seventeen subjects were treated with the chelating agent calcium-disodium-edetate (CaNa2EDTA), the remaining five received no treatment. The aim of the study was to examine the delayed effects of lead poisoning on kidney function and the possible difference in functional impairment between the treated and the non-treated subjects. The results obtained demonstrated a significantly reduced glomerular filtration rate, adjusted for age, in subjects poisoned by lead in the past who failed to receive specific treatment (P < 0.01). This indicates the possibility of marked, delayed adverse effect of lead on the kidneys in cases when lead body burden has not been reduced by treatment.
Restek-Samarzija
N
N
Institut za medicinska istrazivanja i medicinu rada Sveucilista, Zagreb, Hrvatska.
Momcilović
B
B
D000328:Adult; D015913:Chelation Therapy; D005919:Glomerular Filtration Rate; D006801:Humans; D007855:Lead Poisoning / Q000188:drug therapy / Q000503:physiopathology*; D008297:Male; D008875:Middle Aged
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