title: [The validation of the adequacy of chemotherapy in bladder tuberculosis based on a study of bacteriostatic activity].
abstract: Study of the bacteriostatic activity (BA) of the blood, urine and tissue of the tuberculosis-affected urinary bladder after the administration of two tuberculostatic combinations (isoniazid + cycloserine and isoniazid + rifampicin) has demonstrated the difference in the BA curves that were formed in the above media. Use of isoniazid + cycloserine gives rise to a high BA level by 6-9 h with further gradual decrease of the parameters. The combination of isoniazid + cycloserine produces a typical double-humped curve with titre prolongation. The data obtained give evidence on the experience of the use of the first combination of the preparations in patients with fresh circumscribed urinary bladder lesions. The second combination (isoniazid + rifampicin) is indicated in the presence of ulcerous-cicatricial changes in association with a more prolonged circulation of the preparations in the organism (specific features of rifampicin metabolism).
authors.forename: A A
authors.initials: AA
authors.lastname: Dovlatian
authors.forename: N A
authors.initials: NA
authors.lastname: Dzhenzhera
mesh_terms: D001770:Blood Bactericidal Activity / Q000187:drug effects; D003523:Cycloserine / Q000008:administration & dosage / Q000493:pharmacokinetics; D004341:Drug Evaluation; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D007538:Isoniazid / Q000008:administration & dosage / Q000493:pharmacokinetics; D008297:Male; D008875:Middle Aged; D012293:Rifampin / Q000008:administration & dosage / Q000493:pharmacokinetics; D013997:Time Factors; D014018:Tissue Distribution; D014401:Tuberculosis, Urogenital / Q000188:drug therapy* / Q000378:metabolism / Q000382:microbiology; D001743:Urinary Bladder / Q000378:metabolism / Q000382:microbiology; D001745:Urinary Bladder Diseases / Q000188:drug therapy* / Q000378:metabolism / Q000382:microbiology
chemical_list: D003523:Cycloserine; D007538:Isoniazid; D012293:Rifampin
vernacular_title: Obosnovanie adekvatnosti khimioterapii pri tuberkuleze mochevogo puzyria na osnovanii izucheniia bakteriostaticheskoĭ aktivnosti.