Synthesis and pharmacological properties of 2,4-disubstituted 5-amino-6-pyrimidinecarboxylic acid derivatives. Part II.
2,4-Disubstituted 5-amino-6-pyrimidinecarboxylic acid derivatives 5-20 were synthesized and evaluated for their pharmacological activity. Compounds 11-14, 17-19 showed antiaggressive effect, compounds 5, 8, 9, 11, 12 and 19 displayed antiserotonin activity while compound 14 exerted antireserpine action.
Jasztold-Howorko
R
R
Department of Organic Chemistry, Medical Academy, Wrocław, Poland.
Machoń
Z
Z
Wilimowski
M
M
Wojewódzki
W
W
Barczyńska
J
J
Kedzierska
L
L
Orzechowska-Juzwenko
K
K
Duś
E
E
Rutkowska
M
M
Szelag
A
A
D006916:5-Hydroxytryptophan / Q000037:antagonists & inhibitors; D000374:Aggression / Q000187:drug effects; D000818:Animals; D000927:Anticonvulsants / Q000494:pharmacology; D005260:Female; D006591:Hexobarbital / Q000037:antagonists & inhibitors; D008297:Male; D051379:Mice; D009043:Motor Activity / Q000187:drug effects; D010147:Pain Measurement / Q000187:drug effects; D010975:Platelet Aggregation Inhibitors / Q000138:chemical synthesis* / Q000494:pharmacology / Q000633:toxicity; D011743:Pyrimidines / Q000138:chemical synthesis* / Q000494:pharmacology / Q000633:toxicity; D051381:Rats; D017208:Rats, Wistar; D012110:Reserpine / Q000037:antagonists & inhibitors*; D012702:Serotonin Antagonists / Q000138:chemical synthesis* / Q000494:pharmacology / Q000633:toxicity; D013239:Stereotyped Behavior / Q000187:drug effects
D000927:Anticonvulsants; D010975:Platelet Aggregation Inhibitors; D011743:Pyrimidines; D012702:Serotonin Antagonists; D012110:Reserpine; D006591:Hexobarbital; D006916:5-Hydroxytryptophan