[Selection of Penicillium chrysogenum--producer of penicillin with several valuable technologic features].
The efficiency of the routine methods for improvement of P. chrysogenum providing specific selection by several features with testing one of them was studied. A new highly potent strain of P. chrysogenum producing phenoxymethylpenicillin was isolated. The strain is characterized by a shorter fermentation cycle, lower viscosity of the fermentation broth and capacity for synthesizing 32,600 units/ml of phenoxymethylpenicillin under industrial conditions (in a lactose medium) by the 97th hour of the cultivation in fermenters with energy consumption of 1.3 kW. The increased amylolytic activity of the strain and the decreased viscosity of the fermentation broth provided using of the fermentation media containing 3.5 per cent of corn meal.
Rusinov
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SF
D000900:Anti-Bacterial Agents / Q000096:biosynthesis*; D005285:Fermentation / Q000502:physiology; D007218:Industrial Microbiology; D010404:Penicillin V; D010406:Penicillins / Q000096:biosynthesis*; D010408:Penicillium chrysogenum / Q000235:genetics* / Q000254:growth & development / Q000378:metabolism; D012641:Selection, Genetic; D014783:Viscosity
D000900:Anti-Bacterial Agents; D010406:Penicillins; D010404:Penicillin V
Selektsiia Penicillium chrysogenum--produtsenta penitsillina s neskol'kimi poleznymi tekhnologicheskimi priznakami.