title: Neutrophil dysfunction in prepubertal periodontitis associated with Papillon-Lefèvre syndrome.
abstract: Although prepubertal periodontitis (PP) is often associated with the Papillon-Lefèvre (PLS), the etiopathogenetic mechanism in this disease has not been clarified as yet. A three and half year old female with leukocyte chemotaxis deficiency and decrease of T-lymphocytes is presented. The immunohistochemical evaluation of neutrophils showed a reduction of myeloperoxidase content, whereas ultrastructural studies revealed no particular change. The possible role of such a deficiency in the pathogenesis of the periodontal lesion is discussed.
authors.affiliation: Department of Periodontology, University of Palermo.
authors.forename: M
authors.initials: M
authors.lastname: D'Angelo
authors.forename: V
authors.initials: V
authors.lastname: Margiotta
authors.forename: V
authors.initials: V
authors.lastname: Franco
authors.forename: V
authors.initials: V
authors.lastname: Agate
mesh_terms: D010520:Aggressive Periodontitis / Q000175:diagnosis* / Q000209:etiology; D002634:Chemotaxis, Leukocyte; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D007159:Immunologic Tests; D009000:Monocytes / Q000378:metabolism / Q000648:ultrastructure; D009504:Neutrophils / Q000378:metabolism* / Q000648:ultrastructure; D010214:Papillon-Lefevre Disease / Q000175:diagnosis* / Q000209:etiology