[Hyperlipidemia in patients over 60 years old].
The management of hyperlipidemia in individuals aged 60 or over is a serious problem, given the frequency of metabolic abnormalities in this age group. The decision to treat must take into account a number of uncertainties. Hypercholesterolemia is a risk factor in the elderly and, in general, its importance varies like the other major risk factors (hypertension and smoking): the relative risk decreases with age but this decrease in relative risk is associated with an increase in the absolute risk because the prevalence of cardiovascular disease greatly increases with age. The serum cholesterol level increases with age but the physiopathological mechanism os this increase is poorly understood (reduction in the number of LDC receptors?). In the over 70s, serum cholesterol levels decrease, probably because of a selection due to the deaths of subjects at higher risk. No therapeutic trials have been performed to evaluate the effects of lowering the serum cholesterol in the over 60s. In addition, strict application of international recommendations in this age group would result in a large number of therapeutic interventions, the value of which would be questionable. Under these conditions, practical clinical advice is based on reasoned extrapolation of epidemiological data obtained in middle-aged men. Treatment should therefore be reserved for sever forms of hyperlipidemia, taking into consideration the life expectancy of the individual.
Bruckert
E
E
Service d'endocrinologie métabolisme, hôpital Pitié-Salpêtrière, Lyon.
Delahaye
F
F
Richard
J L
JL
Emmerich
J
J
Thomas
D
D
D000368:Aged; D000375:Aging; D002784:Cholesterol / Q000097:blood*; D003327:Coronary Disease / Q000453:epidemiology* / Q000517:prevention & control; D005260:Female; D006801:Humans; D006949:Hyperlipidemias / Q000628:therapy*; D008297:Male; D008875:Middle Aged; D012307:Risk Factors
D002784:Cholesterol
Hyperlipidémie chez le sujet âgé de plus de 60 ans.