title: Genetic polymorphism of complement component C6, C7 and C8(1) in Chinese Han population in northeast China.
abstract: Distributions of complement phenotypes, C6, C7, and C8(1) were studied using thin agarose gel isoelectric focusing (AGIEF) or ultra-thin polyacrylamide gel isoelectric focusing (PAGIEF) and subsequent immunoblotting techniques in 203 Chinese Han population in Liaoning Province of northeast China. The gene frequencies were as follows: C6*A 0.4704, C6*B 0.5049, C6*B2 0.0148, C6*B3 0.0049, and C6*M 0.0049; C7*1 0.8251, C7*2 0.1108, C7*3 0.0320, and C7*4 0.0320; C8(1)*A 0.5567 and C8(1)B 0.4433, respectively. All the observed numbers of the phenotypes were in agreement with the expected numbers under the Hardy-Weinberg equilibrium. The gene frequencies among Chinese subpopulations and other various populations were compared.
authors.affiliation: Department of Forensic Medicine, Kumamoto University School of Medicine, Japan.
authors.forename: S
authors.initials: S
authors.lastname: Tsunenari
authors.forename: K
authors.initials: K
authors.lastname: Kibayashi
authors.forename: T
authors.initials: T
authors.lastname: Higashi
authors.forename: H
authors.initials: H
authors.lastname: Pang
authors.forename: M
authors.initials: M
authors.lastname: Ding
authors.forename: J
authors.initials: J
authors.lastname: Jia
mesh_terms: D044466:Asian People; D002681:China; D003183:Complement C6 / Q000235:genetics*; D003184:Complement C7 / Q000235:genetics*; D003185:Complement C8 / Q000235:genetics*; D005006:Ethnicity; D005787:Gene Frequency; D006801:Humans; D015151:Immunoblotting; D007525:Isoelectric Focusing; D010641:Phenotype; D011110:Polymorphism, Genetic
chemical_list: D003183:Complement C6; D003184:Complement C7; D003185:Complement C8