[Superacute xenogenic rejection: attempted treatment with anti-idiotypic antibodies].
Heart xenotransplantation in the guinea-pig to rat model, a highly discordant combination, is invariably followed by a hyperacute rejection of the graft. Preformed IgMs were shown to be responsible for the destruction of the graft by stimulating the complement cascade. We tried to inhibit preformed antibodies, before transplantation, by inducing anti-idiotypic antibodies using autologous Fab' mu specific for guinea-pig endothelial cells. This treatment seems to exert a neutralizing effect on xenogeneic hyperimmunization, against guinea-pig endothelial cells but not against preformed anti-guinea-pig antibodies.
Salamé
E
E
Laboratoire de Recherche Chirurgicale et d'Immunologie, UER Cochin Port Royal, Paris.
Chereau
C
C
Calmus
Y
Y
Ayani
E
E
Houssin
D
D
Weill
B
B
D000208:Acute Disease; D000818:Animals; D000888:Antibodies, Anti-Idiotypic / Q000627:therapeutic use*; D006084:Graft Rejection / Q000517:prevention & control*; D006168:Guinea Pigs; D016027:Heart Transplantation / Q000379:methods* / Q000401:mortality; D051381:Rats; D014183:Transplantation, Heterologous
D000888:Antibodies, Anti-Idiotypic
Rejet hyperaigu xénogénique: tentative de traitement à l'aide d'anticorps anti-idiotypiques.