title: The response of 99Tcm-methylene diphosphonate and 99Tcm-hexametazime-labelled neutrophils to intra-articular steroid injection in rheumatoid arthritis.
abstract: The synovial and bone uptake of tracer in the knees of patients with rheumatoid arthritis (RA) was quantified using 99Tcm-hexamethyl propylene amine oxime-labelled leucocytes and 99Tcm-methylene diphosphonate (MDP), respectively. Significant neutrophil migration and MDP uptake occurred in the knees of patients with RA irrespective of the disease duration. In all but one patient neutrophil migration was reduced after intra-articular steroid injection. The change in MDP uptake after steroid injection was variable. There was a significant correlation between the percentage reduction in neutrophil migration and pain score, while the latter correlated poorly with the change in MDP uptake. The quantification of the neutrophil component of the inflammatory process is a sensitive index for monitoring RA activity and response to pharmacological interventions, while quantitative bone scintigraphy should not be employed to monitor changes in joint inflammation in patients with RA.
authors.affiliation: Department of Nuclear Medicine, Royal Liverpool University Hospital, UK.
authors.forename: M A
authors.initials: MA
authors.lastname: al-Janabi
authors.forename: R
authors.initials: R
authors.lastname: Sobnack
authors.forename: K K
authors.initials: KK
authors.lastname: Solanki
authors.forename: A K
authors.initials: AK
authors.lastname: Jones
authors.forename: M
authors.initials: M
authors.lastname: Critchley
authors.forename: M L
authors.initials: ML
authors.lastname: Smith
authors.forename: K E
authors.initials: KE
authors.lastname: Britton
authors.forename: E C
authors.initials: EC
authors.lastname: Huskisson
mesh_terms: D000368:Aged; D000893:Anti-Inflammatory Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D001172:Arthritis, Rheumatoid / Q000000981:diagnostic imaging / Q000188:drug therapy*; D002465:Cell Movement / Q000187:drug effects / Q000502:physiology; D005260:Female; D006801:Humans; D007270:Injections, Intra-Articular; D007719:Knee Joint; D008297:Male; D008875:Middle Aged; D009504:Neutrophils / Q000187:drug effects* / Q000502:physiology; D015609:Organotechnetium Compounds; D010091:Oximes; D011877:Radionuclide Imaging; D019690:Technetium Tc 99m Exametazime; D013669:Technetium Tc 99m Medronate; D014222:Triamcinolone Acetonide / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000627:therapeutic use
chemical_list: D000893:Anti-Inflammatory Agents; D015609:Organotechnetium Compounds; D010091:Oximes; D019690:Technetium Tc 99m Exametazime; D014222:Triamcinolone Acetonide; C005900:triamcinolone hexacetonide; D013669:Technetium Tc 99m Medronate