title: [Chemonucleolysis using chymopapain and collagenase. 3-year results of a prospective randomized study].
abstract: 100 patients were prospectively and randomized treated by chemonucleolysis either by collagenase (n = 50/400 ABC-U/disc) or by chymopapain (n = 50/4000 I.U.). The success rate after 1 year was 70% for collagenase and 78% after chymopapain, and 72%/80% after 3 years, respectively. Successful results increased significantly during the first year after treatment and remained stable after that point. After chymopapain, one case of successfully treated anaphylaxis (2%) occurred. After collagenase, 3 cases of secondary sequestrations were observed in cases with primarily closed discograms with intact dorsal longitudinal ligament.
authors.affiliation: Orthopädische Universitätsklinik Bochum, St-Josef-Hospital.
authors.forename: A
authors.initials: A
authors.lastname: Hedtmann
authors.forename: H
authors.initials: H
authors.lastname: Fett
authors.forename: R
authors.initials: R
authors.lastname: Steffen
authors.forename: J
authors.initials: J
authors.lastname: Krämer
mesh_terms: D000293:Adolescent; D000328:Adult; D002917:Chymopapain / Q000008:administration & dosage* / Q000009:adverse effects; D005260:Female; D006801:Humans; D007404:Intervertebral Disc Chemolysis / Q000379:methods*; D007405:Intervertebral Disc Displacement / Q000188:drug therapy*; D008297:Male; D003012:Microbial Collagenase / Q000008:administration & dosage* / Q000009:adverse effects; D008875:Middle Aged; D011446:Prospective Studies
chemical_list: D002917:Chymopapain; D003012:Microbial Collagenase
vernacular_title: Chemonukleolyse mit Chymopapain und Kollagenase. 3-Jahres-Ergebnisse einer prospektiv-randomisierten Studie.