The relationship between reduced glutathione level and glutathione S-transferase activity in sheep erythrocytes.
The relationship between reduced glutathione (GSH) level and glutathione S-transferase (GST) activity in erythrocytes was examined, using sheep erythrocytes, which have varying GSH concentrations, and dog erythrocytes with an inherited high concentration of GSH. There was a positive correlation (r = 0.529, p < 0.001) between the GSH level and GST activity in sheep erythrocytes. In dog erythrocytes, the GST activity in high-GSH cells was significantly (p < 0.001) higher than that in normal-GSH cells. These results indicate that the activity of GST in erythrocytes is directly correlated with the intracellular GSH level.
Goto
I
I
Department of Veterinary Internal Medicine, Faculty of Veterinary Medicine, Hokkaido University, Sapporo, Japan.
Agar
N S
NS
Maede
Y
Y
D000818:Animals; D004285:Dogs; D004912:Erythrocytes / Q000201:enzymology / Q000378:metabolism*; D005978:Glutathione / Q000378:metabolism*; D005982:Glutathione Transferase / Q000378:metabolism*; D012756:Sheep / Q000097:blood*
D005982:Glutathione Transferase; D005978:Glutathione