title: [Gangliosides in neurological pharmacotherapy].
abstract: Gangliosides take part in synaptic transmission, neuronal metabolism and development of nervous tissue. They cooperate with nerve growth factor (NGF) and have positive influence on regeneration of the nervous system impairments. There exist many behavioural and biochemical evidences of gangliosides participation in the regeneration of experimentally injured animal nervous system. The therapeutic effectivity of gangliosides in clinical practice is encouraging. Commercial preparates of gangliosides (Cronassial, Sygen) have been successfully used in the therapy of chronic neuropathies, strokes and subarachnoidal haemorrhages. Among the adverse reactions to these drugs are: local irritation, anxiety and possible detrimental effect in immunological system. Ganglioside preparations need further clinical examinations.
authors.affiliation: Zakładu Farmakologii Katedry Farmakologii Slaskiej Akademii Medycznej, Katowicach.
authors.forename: A
authors.initials: A
authors.lastname: Małecki
authors.forename: E
authors.initials: E
authors.lastname: Małecka
authors.forename: H I
authors.initials: HI
authors.lastname: Trzeciak
mesh_terms: D001921:Brain / Q000187:drug effects; D002561:Cerebrovascular Disorders / Q000188:drug therapy; D003866:Depressive Disorder / Q000139:chemically induced; D005260:Female; D005732:Gangliosides / Q000009:adverse effects / Q000494:pharmacology / Q000627:therapeutic use*; D006801:Humans; D007107:Immune System / Q000187:drug effects; D008297:Male; D009416:Nerve Regeneration / Q000187:drug effects; D009422:Nervous System Diseases / Q000188:drug therapy*; D009431:Neural Conduction / Q000187:drug effects; D013345:Subarachnoid Hemorrhage / Q000188:drug therapy
chemical_list: D005732:Gangliosides
vernacular_title: Gangliozydy w farmakoterapii neurologicznej.