Cerebrospinal fluid neopterin and beta 2-microglobulin levels in neurologically asymptomatic HIV-infected patients before and after initiation of zidovudine treatment.
The effect of zidovudine on beta 2-microglobulin and neopterin in the cerebrospinal fluid (CSF) was studied in ten HIV-seropositive neurologically healthy individuals. CSF concentrations of neopterin decreased by 53% (from 20.3 to 9.5 nmol/l, p < 0.01) and beta 2-microglobulin by 36% (from 2.8 to 1.8 mg/l, p < 0.01) four to eight months after initiation of therapy.
Hagberg
L
L
Dept. of Infectious Diseases, University of Göteborg, Ostra Hospital, Sweden.
Norkrans
G
G
Andersson
M
M
Wachter
H
H
Fuchs
D
D
D001708:Biopterins / Q000031:analogs & derivatives* / Q000134:cerebrospinal fluid; D015658:HIV Infections / Q000134:cerebrospinal fluid / Q000188:drug therapy*; D006801:Humans; D019798:Neopterin; D015215:Zidovudine / Q000627:therapeutic use*; D001613:beta 2-Microglobulin / Q000134:cerebrospinal fluid*
D001613:beta 2-Microglobulin; D001708:Biopterins; D015215:Zidovudine; D019798:Neopterin