[Effect of cyclosporine A on the clinical state and spirometric parameters in patients with steroid-dependent bronchial asthma].
The study aimed at assessing an effect of Cs A on spirometric indices in 30 patients with steroid-dependent bronchial asthma. All patients were treated with triamcinolone in a mean daily dose of 6-8 mg for at least 5 years. Half of patients were given in a double blind trial cyclosporin in a daily dose of 100 mg for 2 years. The remaining 15 patients were not given cyclosporin. All patients were also given corticosteroids, methylxanthines, and mucolytics. Statistically significant increase in FVC, FEV1, and PEFR was noted in patients treated with cyclosporin after 2 years while no change was seen in patients not given Cs. At the same time, a reduction of corticoids doses and diminished of post-steroid symptoms were noted in patients treated with cyclosporin.
Matusiewicz
R
R
I Oddziału Chorób Wewnetrznych Szpitala Grochowskiego, Warszawie.
Urbankowska
B
B
D000328:Adult; D001249:Asthma / Q000188:drug therapy* / Q000503:physiopathology; D016572:Cyclosporine / Q000627:therapeutic use*; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D013147:Spirometry; D019966:Substance-Related Disorders / Q000188:drug therapy*; D014221:Triamcinolone
D014221:Triamcinolone; D016572:Cyclosporine
Wpływ cyklosporyny A na stan kliniczny i wskaźniki spirometryczne u chorych na astme kortykosteroidozalezna.