[Biological characteristics of tumor growth delay in human nasopharyngeal carcinoma xenograft (NPC-837) after irradiation].
Tumor growth and cell cycle of human nasopharyngeal carcinoma xenograft in nude mice (NPC-837) after irradiation were studied. After cobalt-60 irradiation of 5.0Gy, 7.5Gy, 10Gy, 15Gy and 20Gy, the tumor volume was reduced to 80, 70, 50, 35 and 10 percent of the control, respectively. However, the tumors began to grow again. The time (in days) the tumors took to reach the volume of the control was radiation dose-dependent. With 20 Gy irradiation the tumor volume was kept at 10% of the control level for as long as 20 days before regrowth occurred, but it never reached the control level up to 108 days of observation. A mean G2 cell block rate of 1.21% after irradiation was observed and a G2 cell block was marked after 7.5Gy irradiation. The results indicate that NPC-837 is a very radiosensitive and valuable model for the radiobiological research of solid tumors.
Cao
S L
SL
Cancer Hospital, Shanghai Medical University.
D000818:Animals; D002294:Carcinoma, Squamous Cell / Q000473:pathology / Q000532:radiotherapy*; D002452:Cell Count; D002453:Cell Cycle / Q000528:radiation effects; D003037:Cobalt Radioisotopes / Q000627:therapeutic use; D005434:Flow Cytometry; D016195:G2 Phase; D006801:Humans; D051379:Mice; D008807:Mice, Inbred BALB C; D008819:Mice, Nude; D009303:Nasopharyngeal Neoplasms / Q000473:pathology / Q000532:radiotherapy*; D009368:Neoplasm Transplantation
D003037:Cobalt Radioisotopes