Treatment of aggressive cytomegalovirus retinitis with ganciclovir in combination with foscarnet in a child infected with human immunodeficiency virus.
Ganciclovir and foscarnet are both effective for cytomegalovirus retinitis in patients with acquired immunodeficiency syndrome, but the benefits of either agent given alone are limited. A child infected with human immunodeficiency virus who had cytomegalovirus retinitis that progressed despite treatment with either agent alone received the combination of ganciclovir and foscarnet. This treatment resulted in a sustained clinical response.
Butler
K M
KM
Pediatric Branch, National Cancer Institute, National Institutes for Health, Bethesda, MD 20892.
De Smet
M D
MD
Husson
R N
RN
Mueller
B
B
Manjunath
K
K
Montrella
K
K
Lovato
G
G
Jarosinski
P
P
Nussenblatt
R B
RB
Pizzo
P A
PA
D000998:Antiviral Agents / Q000008:administration & dosage*; D002675:Child, Preschool; D003586:Cytomegalovirus Infections / Q000150:complications / Q000188:drug therapy*; D004359:Drug Therapy, Combination; D005260:Female; D017245:Foscarnet; D015774:Ganciclovir / Q000008:administration & dosage*; D015658:HIV Infections / Q000150:complications*; D006801:Humans; D010746:Phosphonoacetic Acid / Q000008:administration & dosage / Q000031:analogs & derivatives*; D012173:Retinitis / Q000150:complications / Q000188:drug therapy*
D000998:Antiviral Agents; D017245:Foscarnet; D010746:Phosphonoacetic Acid; D015774:Ganciclovir