title: [Induction of labor with a new intracervically administered prostaglandin E2 gel. Report of initial experience].
abstract: We report on our experience with the induction of labour using 0.5 mg of prostaglandin E2 gel (Cerviprost, Organon) intracervically. Out of 43 cases, 27 were primiparae. Indication for induction was: 10 post-term pregnancies, 9 PROM's > 24h, 12 foetal and 11 maternal indications. Mean Bishop score before induction was 3.1 and 9 hours later or at the beginning of regular contractions 6.7. In 9 of the 43 cases induction was unsuccessful. There were 23 spontaneous vaginal deliveries, 6 forceps and 5 Caesarean sections. Uterine hyperstimulation was found in 6 cases, 5 of which occurred during the first 16 inductions, and only one was seen during the following 27. A possible reason may be unrecognised extra-amniotic application of the gel. Intracervical prostaglandin seems to be an appropriate method not only for cervical ripening but also for induction of labour in cases with a low Bishop score. Although side effects are rare, sufficient monitoring and control of mother and foetus are mandatory.
authors.affiliation: Universitäts-Frauenklinik, Bern.
authors.forename: M
authors.initials: M
authors.lastname: Ammann
authors.forename: H
authors.initials: H
authors.lastname: Schneider
authors.forename: T
authors.initials: T
authors.lastname: Gyr
authors.forename: P
authors.initials: P
authors.lastname: Dürig
authors.forename: W
authors.initials: W
authors.lastname: Hänggi
authors.forename: B
authors.initials: B
authors.lastname: Huber
mesh_terms: D000282:Administration, Intravaginal; D015148:Cardiotocography / Q000187:drug effects; D002584:Cervix Uteri / Q000187:drug effects*; D002585:Cesarean Section; D015232:Dinoprostone / Q000008:administration & dosage* / Q000009:adverse effects; D005260:Female; D005782:Gels; D006801:Humans; D007231:Infant, Newborn; D007751:Labor, Induced / Q000379:methods*; D009772:Obstetrical Forceps; D011247:Pregnancy
chemical_list: D005782:Gels; D015232:Dinoprostone
vernacular_title: Geburtseinleitung mit einem neuen intrazervikal applizierbaren Prostaglandin E2-Gel. Ein erster Erfahrungsbericht.