[T clones, a means of exploring minor antigens involved in graft versus host reaction].
During MHC-matched bone marrow transplantation, a graft-versus-host reaction (GVH) mediated by donor T lymphocytes and directed against host minor histocompatibility antigens may be observed. The establishment of T cell clones from GVH mice has enabled us to study minor antigens recognized during the reaction. Most of the T cell clones were Thyl+CD4+CD8-alpha beta+. Four minor, weakly polymorphic antigens, were evidenced; two of those antigens, recognized by CD4+ T cell clones, were implicated in GVH. One CD8+ T cell clone cannot provoke GVH mortality. The two "killer" clones express V beta 18 and V beta 2 TCR gene segments, respectively.
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INSERM U 267 Immunogénétique des Allogreffes, Hôpital Paul-Brousse, Villejuif.
D000818:Animals; D001483:Base Sequence / Q000235:genetics; D016026:Bone Marrow Transplantation / Q000379:methods* / Q000401:mortality; D015704:CD4 Antigens / Q000276:immunology; D002999:Clone Cells / Q000502:physiology; D006087:Graft vs Host Reaction / Q000235:genetics / Q000276:immunology*; D051379:Mice; D015778:Minor Histocompatibility Antigens / Q000235:genetics / Q000276:immunology*; D013601:T-Lymphocytes / Q000502:physiology*
D015704:CD4 Antigens; D015778:Minor Histocompatibility Antigens
Les clones T, moyen d'exploration des antigènes mineurs impliqués dans la réaction du greffon contre l'hôte.