title: Isocitrate dehydrogenase kinase/phosphatase: identification of mutations which selectively inhibit phosphatase activity.
abstract: Mutations in aceK, the gene encoding isocitrate dehydrogenase kinase/phosphatase, which selectively inhibit phosphatase activity have been isolated. These mutations yield amino acid substitutions within a 113-residue region of this 578-residue protein. These mutations may define a regulatory domain of this protein.
authors.affiliation: Department of Biochemistry, University of Minnesota, Minneapolis 55455-0347.
authors.forename: T P
authors.initials: TP
authors.lastname: Ikeda
authors.forename: E
authors.initials: E
authors.lastname: Houtz
authors.forename: D C
authors.initials: DC
authors.lastname: LaPorte
mesh_terms: D004252:DNA Mutational Analysis; D004926:Escherichia coli / Q000201:enzymology* / Q000235:genetics; D009154:Mutation / Q000235:genetics; D010749:Phosphoprotein Phosphatases / Q000235:genetics* / Q000378:metabolism; D011494:Protein Kinases / Q000235:genetics* / Q000378:metabolism; D017346:Protein Serine-Threonine Kinases; D014169:Transformation, Bacterial / Q000235:genetics
chemical_list: D011494:Protein Kinases; D017346:Protein Serine-Threonine Kinases; C042301:isocitrate dehydrogenase kinase; C042300:isocitrate dehydrogenase phosphatase; D010749:Phosphoprotein Phosphatases