In vivo effect of cadmium chloride on intestinal colonization of rats by Campylobacter jejuni.
Campylobacter jejuni (10(8) C.F.U) fed intragastrically unto 18 laboratory rats (white whiskers) resulted in colonization of the 18 rats intestines and their eventual excretion of the organism for four months post infection. When 10(8) CFU of C. jejuni was mixed with 10 mu/ml of cadmium chloride (CdCl2) and fed immediately to another set of 18 rats, colonization of rats intestines was greatly reduced and C. jejuni was recovered from two (11%) out of 18 rats and the faeces were positive for C. jejuni for a maximum of 29 days. Six control rats given 1 ml of phosphate buffered saline (PBS) and a second set of another six control animals given 1 ml of PBS containing 10 micrograms/ml of CdCl2 gave negative result for C. jejuni throughout the experiment. This work depicts an in vivo effect of CdCl2 on C. jejuni and may be of importance in the control of C. jejuni colonization in experimental animals.
Epoke
J
J
Department of Medical Microbiology and Parasitology, College of Medicine, University of Lagos, Nigeria.
Obi
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Coker
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D000284:Administration, Oral; D000818:Animals; D001422:Bacterial Adhesion; D002104:Cadmium / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*; D019256:Cadmium Chloride; D002169:Campylobacter Infections / Q000188:drug therapy* / Q000382:microbiology; D016123:Campylobacter jejuni; D002712:Chlorides / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*; D015169:Colony Count, Microbial; D004195:Disease Models, Animal; D004353:Drug Evaluation, Preclinical; D005243:Feces / Q000382:microbiology; D007410:Intestinal Diseases / Q000188:drug therapy* / Q000382:microbiology; D051381:Rats
D002712:Chlorides; D002104:Cadmium; D019256:Cadmium Chloride