Tolerance and long-term efficacy of a fixed combination of atenolol and nifedipine in the treatment of angina pectoris. Stuart Clinical Research Group.
To monitor the tolerance and long-term efficacy of a low-dose fixed combination of 50 mg atenolol and 20 mg nifedipine (slow release formulation) in patients with stable angina pectoris, 157 patients received treatment twice daily in a multi-centre, open-label fashion for periods up to 12 months following a four week run-in period on atenolol 50 mg twice daily. A total of 122 patients completed the study and had data from all treatment visits. In these patients the median number of weekly anginal attacks was halved, compared to the run-in period on atenolol alone following one month's fixed combination treatment, and this benefit was maintained throughout the 12-month study period. In addition, GTN consumption similarly declined on the fixed combination in comparison with the run-in period. Treatment with the fixed combination was not associated with any long-term increase in the frequency of reported side-effects or adverse biochemical changes compared to run-in. The fixed combination of atenolol 50 mg and nifedipine 20 mg reduced anginal frequency and GTN consumption compared to atenolol alone without causing any increase in adverse effects.
Saul
P A
PA
ICI Pharmaceuticals, Wilmslow, Cheshire.
Oliver
I M
IM
Russell
W A
WA
D000328:Adult; D000368:Aged; D000787:Angina Pectoris / Q000188:drug therapy*; D001262:Atenolol / Q000009:adverse effects / Q000627:therapeutic use*; D004338:Drug Combinations; D005260:Female; D006801:Humans; D008134:Long-Term Care; D008297:Male; D008875:Middle Aged; D009543:Nifedipine / Q000009:adverse effects / Q000627:therapeutic use*; D016896:Treatment Outcome
D004338:Drug Combinations; D001262:Atenolol; D009543:Nifedipine