[The filling of bone-implant gaps with autograft, allograft/autologous red marrow and BMP/collagen in animal experiment].
In order to compare the abilities of autograft, allograft/autologous red marrow and bBMP/collagen of promoting ingrowth of bone in a gaped interface of bone/implant, 18 rabbits were used and randomly divided into 2 groups. Specimens were harvested at 2, 4, and 6 weeks. Undecalcified sections were examined with fluorescent microscopy, microradioscopy and analyzed with computer. The results implied: bone ingrowth occurred in all groups except in control group after 6 weeks. The percentage of porous layer occupied by bone in defects was statistically higher in BMP/Col specimens of 4 weeks (P < 0.05). There was no significant difference among the three experimental groups 6 weeks after implantation.
Sun
Y Q
YQ
General Hospital, People's Liberation Army, Beijing.
D000818:Animals; D016026:Bone Marrow Transplantation / Q000379:methods*; D019485:Bone Morphogenetic Proteins; D016723:Bone Remodeling; D016025:Bone Transplantation; D003094:Collagen / Q000627:therapeutic use; D005260:Female; D005269:Femur / Q000473:pathology / Q000601:surgery; D007595:Joint Prosthesis; D008297:Male; D011475:Prosthesis Failure; D011506:Proteins / Q000627:therapeutic use*; D011817:Rabbits; D013977:Tibia / Q000473:pathology / Q000637:transplantation
D019485:Bone Morphogenetic Proteins; D011506:Proteins; D003094:Collagen