[Antianginal activity of cardil and cordafen in patients with non-Q wave myocardial infarction].
The antianginal activity of Cardil, 240-360 mg/day, and Cordafen, 30-60 mg/day, was evaluated in 74 patients with non-Q wave acute myocardial infarction. Repeated 24-hour ECG monitoring was used as an objective tool for the evaluation of their therapeutical efficiency in two randomized groups. Unlike Cordafen, Cardil significantly reduced the average heart rate from 4.7 to 1.5 and the average duration from 20.5 to 11.5 min and the average total duration of myocardial ischemic episodes from 95.1 min/day to 16.7 min/day. Both Cardil and Cordafen considerably reduced the total duration of painful ischemic attacks, but only did Cardil reduce silent episodes (p < 0.001). Both Cardil and Cordafen substantially reduced resting ischemia, but Cardil also decreased the rate of exercise-induced ischemic episodes (p < 0.05).
Nikitin
Iu P
IuP
Kurilovich
V P
VP
D000368:Aged; D004110:Diltiazem / Q000494:pharmacology / Q000627:therapeutic use*; D004562:Electrocardiography; D005260:Female; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000175:diagnosis / Q000188:drug therapy* / Q000503:physiopathology; D009543:Nifedipine / Q000494:pharmacology / Q000627:therapeutic use*; D010507:Periodicity; D016037:Single-Blind Method
D004110:Diltiazem; D009543:Nifedipine
Antianginalńaia aktivnost kardila i kordafena pri infarkte miokarda bez zubtsa Q.