title: A large domain common to sperm receptors (Zp2 and Zp3) and TGF-beta type III receptor.
abstract: A new family of mosaic proteins is defined by sequence analysis. The family is characterized by a 260 residue domain common to proteins of apparently diverse function and tissue specificity: sperm receptors Zp2 and Zp3, betaglycan (also called TGF-beta type III receptor), uromodulin, as well as the major zymogen granule membrane protein (GP-2). The location of the common domain is similar with respect to putative transmembrane regions. The results lead to the hypothesis that this type of domain has a common tertiary structure and that there is a functional similarity in the recognition mechanism of the sperm receptor system and the TGF-beta receptor complex.
authors.affiliation: EMBL, Heidelberg, Germany.
authors.forename: P
authors.initials: P
authors.lastname: Bork
authors.forename: C
authors.initials: C
authors.lastname: Sander
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D006224:Cricetinae; D004285:Dogs; D004527:Egg Proteins; D005260:Female; D006023:Glycoproteins / Q000737:chemistry* / Q000235:genetics; D006801:Humans; D008297:Male; D008562:Membrane Glycoproteins; D008565:Membrane Proteins / Q000737:chemistry; D051379:Mice; D008969:Molecular Sequence Data; D011487:Protein Conformation; D011509:Proteoglycans / Q000737:chemistry; D051381:Rats; D011956:Receptors, Cell Surface / Q000737:chemistry* / Q000235:genetics; D018125:Receptors, Transforming Growth Factor beta; D016415:Sequence Alignment; D012689:Sequence Homology, Nucleic Acid; D012984:Software; D013094:Spermatozoa / Q000737:chemistry*; D013329:Structure-Activity Relationship; D016212:Transforming Growth Factor beta / Q000737:chemistry* / Q000235:genetics; D000072216:Zona Pellucida Glycoproteins
chemical_list: D004527:Egg Proteins; D006023:Glycoproteins; D008562:Membrane Glycoproteins; D008565:Membrane Proteins; D011509:Proteoglycans; D011956:Receptors, Cell Surface; D018125:Receptors, Transforming Growth Factor beta; D016212:Transforming Growth Factor beta; C000606515:ZP2 protein, human; C000606517:ZP3 protein, human; D000072216:Zona Pellucida Glycoproteins; C000606520:Zp2 protein, mouse; C000606521:Zp3 protein, mouse; C071736:betaglycan