Solid phase extraction of phencyclidine from urine followed by capillary gas chromatography/mass spectrometry.
This communication describes a method for the solid phase extraction of phencyclidine (PCP) from urine, followed by GC/MS analysis. The method is linear over the range 5-1000 ng/mL and consistently produces cleaner chromatograms than can be obtained by liquid-liquid extraction. The limits of detection and quantitation are 0.47 and 1.38 ng/mL, respectively. Extraction efficiency, or recovery, was found to be 100.8 +/- 6.5%, and the between-run precision was 3.5% (25 ng/mL, n = 51). This solid phase method for extraction of PCP from urine has several advantages over liquid-liquid extraction for laboratories of any size.
Stevenson
C C
CC
U.S. Army Forensic Toxicology Drug Testing Lab, Ft. Meade, MD 20755.
Cibull
D L
DL
Platoff
G E
GE
Bush
D M
DM
Gere
J A
JA
D002623:Chemistry Techniques, Analytical / Q000379:methods; D008401:Gas Chromatography-Mass Spectrometry / Q000379:methods; D006801:Humans; D010622:Phencyclidine / Q000652:urine*; D012680:Sensitivity and Specificity; D015813:Substance Abuse Detection / Q000379:methods*
D010622:Phencyclidine