Anti-inflammatory properties of zinc protoporphyrin disodium (Zn-PP-2Na).
Anti-inflammatory properties of zinc protoporphyrin disodium (Zn-PP-2Na) were studied. Zn-PP-2Na exhibits anti-allergic action against type III and IV reactions (passive Arthus reaction in rats and tuberculin-induced footpad reaction in mice), but does not affect type I and II reactions (homologous passive cutaneous anaphylaxis in mice and reversed cutaneous anaphylaxis in rats). Zn-PP-2Na also clearly inhibits type II collagen-induced arthritis in mice. The agent inhibits general arthritis symptoms, anti-type-II collagen antibody production and type II collagen-induced delayed type hypersensitivity (DTH) in arthritic mice. Zn-PP-2Na, however, did not affect carrageenin-induced paw edema and histamine- and serotonin-induced skin reactions in rats. Zn-PP-2Na inhibits IL-1-induced mouse lymphocyte proliferation, but does not affect PMA-induced O2- generation from guinea-pig neutrophil. These results indicate that Zn-PP-2Na inhibits type II collagen-induced arthritis in mice due to the antagonism of IL-1 activity and the inhibition of DTH against type II collagen.
Nagai
H
H
Department of Pharmacology, Gifu Pharmaceutical University, Japan.
Kitagaki
K
K
Kuwabara
K
K
Koda
A
A
D000707:Anaphylaxis / Q000209:etiology; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology*; D001168:Arthritis / Q000139:chemically induced / Q000188:drug therapy; D001183:Arthus Reaction / Q000517:prevention & control; D001200:Ascaris / Q000276:immunology; D003094:Collagen; D004487:Edema / Q000139:chemically induced / Q000517:prevention & control; D006967:Hypersensitivity / Q000188:drug therapy; D007375:Interleukin-1 / Q000037:antagonists & inhibitors; D008214:Lymphocytes / Q000187:drug effects / Q000378:metabolism; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D008811:Mice, Inbred DBA; D010047:Ovalbumin / Q000276:immunology; D010101:Oxygen Consumption / Q000187:drug effects; D010323:Passive Cutaneous Anaphylaxis / Q000187:drug effects; D011524:Protoporphyrins / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D012882:Skin Tests
D000894:Anti-Inflammatory Agents, Non-Steroidal; D007375:Interleukin-1; D011524:Protoporphyrins; C017803:zinc protoporphyrin; D010047:Ovalbumin; D003094:Collagen