[5-Iodo-2'-deoxyuridine in the assessment of the individual reaction of experimental tumors to irradiation].
C57BL/6 male mice bearing subcutaneously transplanted melanoma B-16 were used to study the applicability of 5-iodine-2'-deoxyuridine labeled with iodine 125 and 131 radionuclides to assess individual tumor response to radiation. The experiments using intact animals and those locally irradiated in the dose of 10 Gy revealed a correlation between excretion of the above-mentioned radioactive labels from tumor area and tumor growth rate for each mouse (correlation coefficient r = 0.93-0.97). 5-Iodine-2'-deoxyuridine excretion rate measurement can be used in express (24-48 hr) tests of individual tumor response to radiation.
Spryshkova
R A
RA
Grigor'eva
E Iu
EIu
Brattsev
V A
VA
Sevast'ianov
A I
AI
Naĭdenov
M G
MG
D000818:Animals; D005069:Evaluation Studies as Topic; D007065:Idoxuridine / Q000493:pharmacokinetics; D007457:Iodine Radioisotopes; D008297:Male; D008546:Melanoma, Experimental / Q000453:epidemiology / Q000378:metabolism / Q000532:radiotherapy*; D051379:Mice; D008810:Mice, Inbred C57BL; D009368:Neoplasm Transplantation; D011379:Prognosis; D012044:Regression Analysis; D013997:Time Factors
D007457:Iodine Radioisotopes; D007065:Idoxuridine
5-Iodo-2'-dezoksiuridin v otsenke individual'noĭ reaktsii éksperimental'nykh opukholeĭ na obluchenie.