[Effect of flavone glycosides of Epimedium koreanum on murine fibrinolytic system and apoplectic mortality].
The enhancement of fibrinolytic ability of stimulated murine macrophages by flavone glycosides of Epimedium koreanum (TFG) was measured by the [125I]-fibrin-coated plate method. The activity of the plasminogen activator (PA) induced by TFG was determined by a spectrophotometric assay. The activity of PA produced by TFG-stimulated macrophages was 0.731 IU/ML. (P < 0.01). TFG-stimulated macrophages showed rapid fibrinolysis. The activity of stimulated macrophages was approximately 2.8 fold that of the control. In in vivo experiments, the effect of TFG on spontaneously hypertensive and apoplexy rats (SHRsp) was very evident. The abiotic rate of TFG-stimulated rats was 5%, while that of the control group was 90%. TFG showed obvious hypotensive activity as well.
Shan
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Institute of Medicinal Biotechnology, Beijing.
D000818:Animals; D002561:Cerebrovascular Disorders / Q000188:drug therapy / Q000401:mortality; D004365:Drugs, Chinese Herbal / Q000494:pharmacology* / Q000627:therapeutic use; D005342:Fibrinolysis / Q000187:drug effects*; D005419:Flavonoids / Q000494:pharmacology* / Q000627:therapeutic use; D006027:Glycosides / Q000494:pharmacology* / Q000627:therapeutic use; D008264:Macrophages / Q000187:drug effects; D008297:Male; D051379:Mice; D010529:Peritoneal Cavity / Q000166:cytology; D010960:Plasminogen Activators / Q000096:biosynthesis / Q000097:blood*; D051381:Rats; D011918:Rats, Inbred SHR
D004365:Drugs, Chinese Herbal; D005419:Flavonoids; D006027:Glycosides; D010960:Plasminogen Activators