title: [Effects of different intramedullary stabilizing procedures of the femur on lung function in polytrauma].
abstract: We investigated the effects of primary (< 24 h) intramedullary femoral nailing on lung function and pulmonary hemodynamics in multiple trauma patients. The standard procedure following reaming of the medullary canal (AFN) was compared with a new procedure using a small, solid nail without prior reaming (UFN). Pulmonary hemodynamics were determined using a pulmonary artery catheter. Global lung function was assessed by means of the oxygenation ratio (PaO2/FiO2). Concentrations of elastase and the platelet count as a general parameter of the clinical course were determined from central venous blood during and 3 days after surgery. The lung function was stable in UFN patients (n = 6), but decreased significantly in AFN patients (n = 10) from 353 +/- 24 (PaO2/FiO2 preoperative) to 260 +/- 28 (PaO2/FiO2 postoperative) and did not improve until 48 h later. Pulmonary artery pressure (Pap) remained within normal limits in UFN patients, whereas in AFN patients Pap increased from 27.4 +/- 3 mm Hg (preoperative) to 37 +/- 3 mm Hg during reaming and did not normalize until 1 h after insertion of the nail. The platelet count remained unchanged in UFN patients and dropped in AFN patients from 143 +/- 25 x 1000 cells/ml blood (preoperative) to 87.5 +/- 15 x 1000 cells/ml blood 2 days after surgery. Our measurements did not show an increase in central venous triglycerides in the AFN group, probably because bone marrow does not become immediately soluble. There was no significant difference between the increase of elactase levels in the two groups. The femoral nailing procedure with reaming in multiple trauma patients involves a potential risk to the lung.(ABSTRACT TRUNCATED AT 250 WORDS)
authors.affiliation: Unfallchirurgische Klinik, Medizinische Hochschule Hannover.
authors.forename: H C
authors.initials: HC
authors.lastname: Pape
authors.forename: G
authors.initials: G
authors.lastname: Regel
authors.forename: A
authors.initials: A
authors.lastname: Dwenger
authors.forename: C
authors.initials: C
authors.lastname: Krettek
authors.forename: D
authors.initials: D
authors.lastname: Mehler
authors.forename: J A
authors.initials: JA
authors.lastname: Sturm
authors.forename: H
authors.initials: H
authors.lastname: Tscherne
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D005260:Female; D005264:Femoral Fractures / Q000503:physiopathology / Q000601:surgery*; D005594:Fracture Fixation, Intramedullary / Q000379:methods*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009104:Multiple Trauma / Q000503:physiopathology / Q000601:surgery*; D011175:Positive-Pressure Respiration; D011183:Postoperative Complications / Q000503:physiopathology*; D011669:Pulmonary Wedge Pressure / Q000502:physiology; D012128:Respiratory Distress Syndrome / Q000503:physiopathology*; D012129:Respiratory Function Tests; D012307:Risk Factors
vernacular_title: Effekte unterschiedlicher intramedullärer Stabilisierungsverfahren des Femurs auf die Lungenfunktion bei Polytrauma.