Myocardial oxygen supply under critical conditions, the effects of hemodilution and fluorocarbons.
This article reviews the factors influencing myocardial oxygen supply and demand. The regulative mechanisms in coronary blood flow, especially in critical conditions, are explained. Myocardial oxygenation in coronary artery disease is discussed with special reference to pharmacological intervention. An extensive evaluation of the effects of hemodilution on both the healthy and diseased heart is presented. Effects of hemodilution with fluorocarbons for the treatment or prevention of myocardial ischemia are shown with the aid of intramyocardial oxygen partial pressure measurements.
Fennema
M
M
Department of Anesthesiology, Erasmus University, Rotterdam, The Netherlands.
Erdmann
W
W
Faithfull
N S
NS
D000818:Animals; D001802:Blood Substitutes / Q000627:therapeutic use*; D003326:Coronary Circulation; D003327:Coronary Disease / Q000503:physiopathology* / Q000628:therapy*; D005466:Fluorocarbons / Q000627:therapeutic use*; D006438:Hemodilution; D006706:Homeostasis; D006801:Humans; D008955:Models, Cardiovascular; D009203:Myocardial Infarction / Q000503:physiopathology* / Q000628:therapy*; D009206:Myocardium / Q000378:metabolism*; D010101:Oxygen Consumption
D001802:Blood Substitutes; D005466:Fluorocarbons