title: Effects of a protein-rich diet during convalescence from shigellosis on catch-up growth, serum proteins, and insulin-like growth factor-I.
abstract: Shigellosis in children can cause growth retardation, worsening of malnutrition, and hypoproteinemia. To assess the effects of ingestion of a protein-rich diet during convalescence, 22 children aged 2 to 4 y with culture-proven shigellosis were randomly assigned after 5 d of antibiotic treatment to 21-d feeding regimens of either a 150 kcal/kg/d high-protein diet with 15% of calories as protein or an isocaloric control diet with 6% of calories as protein. At the start and end of dietary treatment, weight, height, mid-arm circumference, skinfold thickness, serum protein concentrations, and serum IGF-I were measured. Means of weight gain and increases in mid-arm circumference were greater in children fed high-protein diets than those fed control diets (1.23 versus 0.76 kg; 1.40 versus 0.96 cm; p < 0.05). Mean increase in height in children fed high-protein diets (0.83 cm) was not significantly greater than with control diets (0.74 cm). Mean increases in serum concentrations of total protein, prealbumin, and retinol-binding protein were greater in the high-protein group than in controls (p < 0.05). Mean serum concentrations of IGF-I were low in both groups before treatment [4.2 +/- 2.6 nmol/L (31.9 +/- 19.6 ng/mL) in controls; 3.1 +/- 3.4 nmol/L (24.0 +/- 26.3 ng/mL) in the high-protein group] but increased more in the high-protein group [39.0 +/- 16.2 nmol/L (298 +/- 124 ng/mL)] than in the control group [16.7 +/- 9.2 nmol/L (128 +/- 70 ng/mL), p < 0.01].(ABSTRACT TRUNCATED AT 250 WORDS)
authors.affiliation: International Centre of Diarrheal Disease Research, Bangladesh.
authors.forename: I
authors.initials: I
authors.lastname: Kabir
authors.forename: T
authors.initials: T
authors.lastname: Butler
authors.forename: L E
authors.initials: LE
authors.lastname: Underwood
authors.forename: M M
authors.initials: MM
authors.lastname: Rahman
mesh_terms: D001798:Blood Proteins / Q000378:metabolism; D002675:Child, Preschool; D004044:Dietary Proteins / Q000008:administration & dosage*; D004405:Dysentery, Bacillary / Q000097:blood / Q000178:diet therapy* / Q000473:pathology; D005260:Female; D006128:Growth; D006801:Humans; D007334:Insulin-Like Growth Factor I / Q000378:metabolism; D008297:Male
chemical_list: D001798:Blood Proteins; D004044:Dietary Proteins; D007334:Insulin-Like Growth Factor I