title: [The efficacy of vitogepat and sirepar in combination with karsil in chronic liver lesions].
abstract: It has been shown in experiments on white rats that chronic (for one month) intoxication with CCl4 and C2H5OH results in liver injury. It manifests by activation of aminotransferases (ALT, AST) and alkaline phosphatase in blood serum, initiation of lipid peroxidation, depletion of the liver pool of reduced glutathione, and suppression of bile production. The liver preparations (sirepar and vitohepat) reduce hepatotoxicity of the poisons in question. The use of vitohepat and sirepar in combination with carsil potentiated hepatoprotective and antioxidative activity of the liver preparations.
authors.forename: N P
authors.initials: NP
authors.lastname: Skakun
authors.forename: I P
authors.initials: IP
authors.lastname: Moseĭchuk
authors.forename: Ia Ia
authors.initials: IaIa
authors.lastname: Gil'
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000627:therapeutic use*; D002252:Carbon Tetrachloride Poisoning / Q000097:blood / Q000188:drug therapy*; D056486:Chemical and Drug Induced Liver Injury / Q000097:blood / Q000188:drug therapy*; D002908:Chronic Disease; D004353:Drug Evaluation, Preclinical; D004359:Drug Therapy, Combination; D006519:Hepatitis, Alcoholic / Q000097:blood / Q000188:drug therapy*; D008110:Liver Extracts / Q000627:therapeutic use*; D008297:Male; D051381:Rats; D012838:Silymarin / Q000627:therapeutic use*
chemical_list: D000975:Antioxidants; D008110:Liver Extracts; D012838:Silymarin; C014814:sirepar
vernacular_title: Effektivnost' vitogepata i sirepara v sochetanii s karsilom pri khronicheskom porazhenii pecheni.