Extension of lifespan in mice treated with Dinh lang (Policias fruticosum L.) and (-)deprenyl.
The effect of Dinh lang root extract (DLRE) and (-)deprenyl on memory function and lifespan was examined in OFA-1 male mice. Treatments of either DLRE, (-)deprenyl or their combination were carried out 3 times a week starting at 12 months of age and following to the end of life. DLRE and (-)deprenyl significantly increased the memory function as well as surviving time of aged mice. The drug-treated animals showed a lower rate of loss of body weight than saline treated ones. It suggested that DLRE and (-)deprenyl did not prolong lifespan of mice by suppressing food intake. The combined treatment of DLRE and (-)deprenyl proved to be the most effective.
Yen
T T
TT
Department of Pharmacology, Semmelweis University Medical School, Budapest, Hungary.
Knoll
J
J
D000818:Animals; D001362:Avoidance Learning / Q000187:drug effects; D001835:Body Weight / Q000187:drug effects; D008136:Longevity / Q000187:drug effects*; D008297:Male; D008568:Memory / Q000187:drug effects; D051379:Mice; D008815:Mice, Inbred Strains; D009369:Neoplasms / Q000453:epidemiology; D010936:Plant Extracts / Q000494:pharmacology*; D012642:Selegiline / Q000494:pharmacology*
D010936:Plant Extracts; D012642:Selegiline