[Study on the immunization effect of measles vaccine by capture-EIA].
Capture-EIA was applied to detect specific IgM antibody (SIgM) to measles virus in paired sera from 72 children before and after primary vaccination and HI antibody was also tested simultaneously. The SIgM and HI antibodies were not detected in 72 prevaccinated and 7 post-inoculated sera by both the capture-EIA and HI test. Among the 65 sera-conversion samples by HI test in the 15 days after immunization, comparing with the results obtained by the capture-EIA, the comformability were 83-100%. The results showed that there was a certain relationship between the level of SIgM produced and the vaccine dose inoculated. So, the results indicated that for investigation of the effect of immunization with measles vaccine. Capture-EIA is as good as HI test.
Fang
H
H
National Institute for the Control of Pharmaceutical and Biological Products, Beijing.
D000914:Antibodies, Viral / Q000097:blood*; D006385:Hemagglutination Inhibition Tests; D006801:Humans; D007124:Immunoenzyme Techniques; D007075:Immunoglobulin M / Q000097:blood*; D007223:Infant; D008457:Measles / Q000517:prevention & control*; D008458:Measles Vaccine / Q000276:immunology*; D008459:Measles virus / Q000276:immunology; D014611:Vaccination
D000914:Antibodies, Viral; D007075:Immunoglobulin M; D008458:Measles Vaccine