Theoretical study about the variability of the genome of foot-and-mouth disease viruses.
1. The possibilities of change in amino acids of a protein are discussed in terms of a point mutation. 2. Whereas Met and Trp are forced to change due to a point mutation, other amino acids (Ala, Arg, Gly, Leu, Pro and Val) have a probability of 1/3 to survive in the sequence. 3. On basis of these considerations, the genome from 5 strains (CSP, C3Ind, O1K, A10 and A12) of the foot-and-mouth disease virus was studied. 4. A hypothetical genealogic tree for these strains is suggested, where CSP and C3Ind are close and also A10 and A12. O1K is closer to A10 and A12 than to CSP or C3Ind.
Franco
R
R
Departament de Bioquímica i Fisiologia, Facultat de Química, Universitat de Barcelona, Catalunya, Spain.
Centelles
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JJ
D005537:Aphthovirus / Q000235:genetics*; D005075:Biological Evolution; D003062:Codon; D014644:Genetic Variation; D016679:Genome, Viral; D009154:Mutation; D012367:RNA, Viral / Q000235:genetics; D013045:Species Specificity
D003062:Codon; D012367:RNA, Viral