Hypoxia and fatty acids in immature nervous tissue in the rat.
In experiments on 2-day-old rats (Wistar strain, our own breed), we studied the effect of altitude hypoxia (9000 m, 60 min) on the proportion of individual fatty acids in the brain (the cortex+the diencephalon+the cranial third of the mesencephalon). We found that hypoxia significantly altered the proportion of the various fatty acids, with a significant increase in the proportion of group n-3 polyenoic fatty acids at the expense of saturated and monoenoic acids. The results fully confirm the conception that one of the most important mechanisms responsible for the high resistance of new born mammals to oxygen deficiency is the ability of immature nervous tissue to activate, in particular, elongation (the elongation of fatty acids) and/or lipogenetic processes.
Mourek
J
J
Institute of Physiology, First Faculty of Medicine, Charles University, Prague.
Base
J
J
Smídová
L
L
D000818:Animals; D000831:Animals, Newborn / Q000502:physiology*; D001921:Brain / Q000378:metabolism*; D005227:Fatty Acids / Q000378:metabolism*; D000860:Hypoxia / Q000378:metabolism*; D051381:Rats; D017208:Rats, Wistar
D005227:Fatty Acids