[Anaphylaxis caused by carboxymethylcellulose: report of 2 cases of shock from injectable corticoids].
Two cases of anaphylactic shock are reported, occurring after intra-articular injections of corticosteroids, containing carboxymethylcellulose (CMC), benzylic acid, polysorbate 80, and merthiolate. Skin tests and leukocyte histamine release are positive to CMC and negative to the other substances including the corticosteroids: prednisolone acetate and cortivazol . No cross-reactivity with hydroxypropylcellulose was demonstrated. These tests lead to incriminate CMC in these patients. Anaphylaxis to CMC seems exceptional, though CMC is widely used in agro-alimentary and pharmaceutical industries, as well as hydroxypropylcellulose. In one case, the possibility of a sensitization by CMC as a food additive is discussed, insofar as the patient has a fixed eruption which has been suspected to be owed to intolerance to food additives.
Beaudouin
E
E
Service de Médecine D, Immunologie Clinique et Allergologie, Centre hospitalier Universitaire de Nancy, Nancy-Vandoeuvre.
Kanny
G
G
Gueant
J L
JL
Moneret-Vautrin
D A
DA
D000707:Anaphylaxis / Q000139:chemically induced*; D002266:Carboxymethylcellulose Sodium / Q000009:adverse effects*; D003692:Delayed-Action Preparations; D004337:Drug Carriers / Q000009:adverse effects*; D003875:Drug Eruptions / Q000209:etiology; D004342:Drug Hypersensitivity / Q000209:etiology*; D005260:Female; D005938:Glucocorticoids / Q000009:adverse effects; D006801:Humans; D007428:Intradermal Tests; D008297:Male; D008875:Middle Aged; D011239:Prednisolone / Q000009:adverse effects / Q000031:analogs & derivatives; D011281:Pregnatrienes / Q000009:adverse effects
D003692:Delayed-Action Preparations; D004337:Drug Carriers; D005938:Glucocorticoids; D011281:Pregnatrienes; C009935:prednisolone acetate; D011239:Prednisolone; D002266:Carboxymethylcellulose Sodium; C005924:cortivazol
Anaphylaxie à la carboxyméthylcellulose: à propos de deux cas de chocs à des corticoïdes injectables.