Parkinsonian-like tremor induced by a combined application of chlorpromazine and pentobarbitone in cats with left-paw preference.
A Parkinsonian-like tremor can be induced by a combined application of chlorpromazine and pentobarbitone in cats. Interestingly enough, only cats with left-paw preference were found to have a predisposition to this drug-induced tremor. The cats with ambidexterity and right-preference in paw use did not show any visible tremorogenic action of these drugs. Especially the proximal muscles of all four extremities showed oscillations with a frequency of about 12 per second in all animals tested, which completely disappeared after i.v. application of lioresal, atropine and biperiden. It was suggested that this new drug-induced tremor model may reflect an impairment within the cortico-striato-pallido-thalamo-cortical feedback loop. It was also concluded that left-handers may have an increased predisposition to centrally acting drugs than nonleft-handers.
Tan
U
U
Atatürk University, Medical Faculty, Department of Physiology, Erzurum, Turkey.
Gepdiremen
A
A
Kutlu
N
N
Cankaya
A
A
D000818:Animals; D001285:Atropine / Q000627:therapeutic use; D001418:Baclofen / Q000627:therapeutic use; D001712:Biperiden / Q000627:therapeutic use; D002415:Cats; D002746:Chlorpromazine / Q000633:toxicity*; D005246:Feedback / Q000502:physiology; D005260:Female; D007839:Functional Laterality / Q000502:physiology*; D008297:Male; D010302:Parkinson Disease, Secondary / Q000139:chemically induced* / Q000188:drug therapy; D010424:Pentobarbital / Q000633:toxicity*; D014202:Tremor / Q000139:chemically induced* / Q000188:drug therapy
D001712:Biperiden; D001285:Atropine; D001418:Baclofen; D010424:Pentobarbital; D002746:Chlorpromazine