title: Nucleotide sequence analysis of a homologue of herpes simplex virus type 1 gene US9 found in the genome of simian herpes B virus.
abstract: The 10K gene of simian herpes B virus (SHBV) has been located and the nucleotide sequence determined. Its relationship to homologous genes in other herpes-viruses has been examined. The SHBV 10K gene exhibits a closer relationship to its homologue in HSV-1 than to those in the other viruses studied. Nucleotide sequence identity of 61% was found between the HSV-1 and SHBV 10K genes, and 57% identity was found between the corresponding predicted protein sequences. A comparison of the amino acid sequences of the herpesvirus 10K proteins has revealed a number of conserved features. These are examined in relation to possible functions of the 10K proteins. Implications for evolutionary relationships between SHBV and other herpesviruses are discussed.
authors.affiliation: Chemical and Biological Defence Establishment, Salisbury, Wiltshire, U.K.
authors.forename: A M
authors.initials: AM
authors.lastname: Killeen
authors.forename: L
authors.initials: L
authors.lastname: Harrington
authors.forename: L V
authors.initials: LV
authors.lastname: Wall
authors.forename: D C
authors.initials: DC
authors.lastname: Kelly
mesh_terms: D000595:Amino Acid Sequence; D001483:Base Sequence; D005814:Genes, Viral / Q000235:genetics*; D006568:Herpesvirus 1, Cercopithecine / Q000235:genetics*; D008969:Molecular Sequence Data; D016366:Open Reading Frames / Q000235:genetics; D012689:Sequence Homology, Nucleic Acid; D018139:Simplexvirus / Q000235:genetics; D014764:Viral Proteins / Q000235:genetics*
chemical_list: D014764:Viral Proteins