[Use of immunosorption for selective decrease of lipoprotein (A) levels in patients with coronary atherosclerosis].
Lipoprotein (a) [L(a)] is an atherogenic lipoprotein, its human plasma concentration correlates with the occurrence of coronary heart disease. The procedure for selectively removing L(a) with an anti-L(a) immunosorbent was performed to treat 3 patients who had high L(a), normal total cholesterol and other lipoprotein levels. All the patients had coronary stenosis as documented by angiography. After L(a)-apheresis, the level of L(a) decreased by 72%, while that of other plasma components, including low density lipoproteins virtually unchanged. Thus, the procedure of L(a)-apheresis is an effective and safe method for lowering human blood L(a) concentrations. In addition, this in vivo model allows information on L(a) metabolism to be obtained.
Susekov
A V
AV
Afanaséva
O I
OI
Adamova
I Iu
IIu
Liakishev
A A
AA
Kukharchuk
V V
VV
Pokrovskiĭ
S N
SN
D000328:Adult; D003324:Coronary Artery Disease / Q000097:blood* / Q000175:diagnosis / Q000628:therapy*; D015716:Electrocardiography, Ambulatory; D006801:Humans; D007163:Immunosorbent Techniques; D017270:Lipoprotein(a) / Q000097:blood*; D008297:Male; D008875:Middle Aged; D010956:Plasmapheresis / Q000379:methods
D017270:Lipoprotein(a)
Primenenie immunosorbtsii dlia selektivnogo snizheniia urovnia lipoproteida (a) u bolńykh aterosclerozom.