title: Effects of inspired oxygen concentration on in vivo redox reaction of nitroxide radicals in whole mice.
abstract: Effects of inspired oxygen concentration on metabolism of nitroxide radical were measured in whole mice by using in vivo ESR. Oxygen concentration influenced spin-clearance of nitroxide differently in abdomen and head, suggesting that either O2 concentrations or metabolic mechanisms of nitroxide in the two domains were different.
authors.affiliation: Department of Health Chemistry, School of Pharmaceutical Sciences, Showa University, Tokyo, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Miura
authors.forename: H
authors.initials: H
authors.lastname: Utsumi
authors.forename: A
authors.initials: A
authors.lastname: Hamada
mesh_terms: D000818:Animals; D003497:Cyclic N-Oxides / Q000378:metabolism* / Q000493:pharmacokinetics; D004578:Electron Spin Resonance Spectroscopy; D005260:Female; D005609:Free Radicals; D001239:Inhalation; D008657:Metabolic Clearance Rate; D051379:Mice; D008815:Mice, Inbred Strains; D010084:Oxidation-Reduction; D010100:Oxygen / Q000378:metabolism*; D013113:Spin Labels; D013997:Time Factors; D014018:Tissue Distribution
chemical_list: D003497:Cyclic N-Oxides; D005609:Free Radicals; D013113:Spin Labels; C047253:3-carbamoyl-2,2,5,5-tetramethyl-3-pyrroline-1-yloxyl; D010100:Oxygen; C001803:tempol