Beta A4 amyloid protein and its precursor in Alzheimer's disease.
The beta A4 amyloid protein is now understood to play a pivotal role in the development of Alzheimer's disease. This protein is generated by the abnormal processing of the amyloid protein precursor, a large membrane glycoprotein. Insights into the mechanisms of this abnormal processing will give information relevant to the design of new therapeutic strategies for Alzheimer's disease.
Bush
A I
AI
Department of Pathology, University of Melbourne, Parkville, Australia.
Beyreuther
K
K
Masters
C L
CL
D000544:Alzheimer Disease / Q000235:genetics / Q000378:metabolism*; D000595:Amino Acid Sequence; D016229:Amyloid beta-Peptides / Q000235:genetics / Q000502:physiology*; D016564:Amyloid beta-Protein Precursor / Q000502:physiology; D000818:Animals; D006801:Humans; D008969:Molecular Sequence Data
D016229:Amyloid beta-Peptides; D016564:Amyloid beta-Protein Precursor