Complement (C3) levels and activation in rabbits experimentally infected with Trypanosoma evansi.
Rocket immunoelectrophoresis was used to monitor the levels of the third complement component (C3) in the blood of rabbits experimentally infected with Trypanosoma evansi. Although a reduction in the circulating levels of C3 was associated with C3 activation in rabbits with high levels of parasitaemia, there was no evidence for C3 activation in uninfected rabbits, rabbits with early-stage, light infections or rabbits cleared of infection by drug treatment. Host-tolerance to current infection and to re-exposure to the parasite are probably affected by such changes in C3.
Uche
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Royal Veterinary College, London, U.K.
Jones
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D000818:Animals; D003167:Complement Activation; D003176:Complement C3 / Q000032:analysis*; D004133:Diminazene / Q000031:analogs & derivatives / Q000627:therapeutic use; D005260:Female; D011817:Rabbits; D013997:Time Factors; D014344:Trypanocidal Agents / Q000627:therapeutic use; D014352:Trypanosomiasis / Q000188:drug therapy / Q000276:immunology* / Q000469:parasitology
D003176:Complement C3; D014344:Trypanocidal Agents; C003915:diminazene aceturate; D004133:Diminazene