title: Propofol to provide sedation after coronary artery bypass surgery. A comparison of two fixed rate infusion regimens.
abstract: Propofol (2,6, di-isopropylphenol) was given by continuous intravenous infusion to provide sedation following coronary artery bypass surgery. The need for additional sedation, analgesia and hypotensive agents was assessed at two propofol infusion rates (10 or 25 micrograms/kg/min). Both rates provided clinically satisfactory conditions. There were no differences in the requirements for analgesia or vasodilators between the groups. The higher infusion rate of 25 micrograms/kg/min was associated with a lower requirement for additional sedation but a more frequent need to stop the infusion temporarily to prevent hypotension.
authors.affiliation: Nuffield Department of Anaesthetics, John Radcliffe Hospital, Oxford, United Kingdom.
authors.forename: M
authors.initials: M
authors.lastname: O'Connor
authors.forename: P
authors.initials: P
authors.lastname: Stow
authors.forename: A
authors.initials: A
authors.lastname: Mortimer
authors.forename: A
authors.initials: A
authors.lastname: Fisher
authors.forename: J W
authors.initials: JW
authors.lastname: Sear
mesh_terms: D000328:Adult; D000368:Aged; D001774:Blood Chemical Analysis; D001026:Coronary Artery Bypass; D006801:Humans; D007262:Infusions, Intravenous; D008875:Middle Aged; D010149:Postoperative Pain / Q000188:drug therapy*; D015742:Propofol / Q000008:administration & dosage*
chemical_list: D015742:Propofol