[The modulator effect of bradykinin with respect to tracheobronchial clearance in healthy subjects].
Bradykinin (Bk), a vasoactive nonapeptide which has been proposed as mediator in the pathogenesis of bronchial asthma, is a potent secretagogue in canine airways and in human nasal mucosa in vivo. A study was carried out in order to evaluate the effect of inhaled Bk on tracheobronchial clearance (TBC), measured by a radioaerosol technique in 10 healthy volunteers. Subjects inhaled Bk (8 mg/mL) or vehicle placebo on two occasions, at least 2 weeks apart, in a double blind and randomized fashion 30 min after radioaerosol inhalation. TBC, expressed as the area under the tracheobronchial radioaerosol retention curve calculated for the first 6 hours (AUC 0-6h), was enhanced in 9 of 10 subjects following inhaled Bk when compared to placebo. The mean values for AUC 0-6h were significantly reduced from 132%.h to 92%.h (p < 0.001) with placebo and Bk respectively. We conclude that Bk has a marked effect on tracheobronchial clearance in normal human airways.
Polosa
R
R
Southampton General Hospital, Gran Bretagna.
Pavia
D
D
Hasani
A
A
Prosperini
G
G
Clarke
S
S
Holgate
S T
ST
D000328:Adult; D000336:Aerosols; D001920:Bradykinin / Q000008:administration & dosage / Q000494:pharmacology*; D001980:Bronchi / Q000187:drug effects* / Q000502:physiology; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009079:Mucociliary Clearance / Q000187:drug effects* / Q000502:physiology; D012016:Reference Values; D012129:Respiratory Function Tests; D013667:Technetium; D014132:Trachea / Q000187:drug effects* / Q000502:physiology
D000336:Aerosols; D013667:Technetium; D001920:Bradykinin
Effetto modulatore della bradichinina nei confronti della clearance tracheobronchiale in soggetti sani.