[Psychophysiological characteristics and metabolic indices of neurotransmitter metabolism in patients ill with endogenous depression].
Research was conducted upon 28 patients with a diagnosis of endogenous depression after their pharmacological treatment with imipramine or chlorimipramine. The investigation considered the interrelationship between psychophysiological parameters (heart rate, respiration rhythm, postural muscular tension) and the indices of the cholinergic and adrenergic systems (kinetic parameters of choline transport in the blood; Vmax, the activity of plasmic pseudocholinesterase, Che; blood acetylcholinesterase AChE, monoaminoxidase in blood platelets, MAO; and dopamine beta hydroxylase DBH). The results indicate that during relapse of endogenous depression there occurs an imbalance in the cholinergic-adrenergic systems which may be the result of some somatic symptoms typically found in the depression syndrome. The appearance, after pharmacotherapy, of a correlation between the indices of the activity of the cholinergic system with the respiratory rhythm suggest that the part played by the cholinergic mechanism in the regulation of autonomic processes normalizes itself during the course of successful therapy. The appearance of characteristic correlations between the activity of the cholinergic and adrenergic systems and the psychophysiological parameters in the presence of relatively low psychological stress seems to accompany successful treatment with imipramine and chlorimipramine.
Wójcik
M
M
II Kliniki Psychiatrycznej i Zakładu Biochemii Instytutu Psychiatrii i Neurologii, Warszawie.
Bidziński
A
A
Slósarska
M
M
Puzyński
S
S
D000328:Adult; D000368:Aged; D002794:Choline / Q000378:metabolism; D002802:Cholinesterases / Q000378:metabolism; D002997:Clomipramine / Q000494:pharmacology / Q000627:therapeutic use*; D003866:Depressive Disorder / Q000188:drug therapy* / Q000378:metabolism; D004299:Dopamine beta-Hydroxylase / Q000378:metabolism; D005260:Female; D006339:Heart Rate; D006801:Humans; D007099:Imipramine / Q000494:pharmacology / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D008995:Monoamine Oxidase / Q000378:metabolism; D012119:Respiration
D004299:Dopamine beta-Hydroxylase; D008995:Monoamine Oxidase; D002802:Cholinesterases; D002794:Choline; D002997:Clomipramine; D007099:Imipramine
Cechy psychofizjologiczne a wskaźniki metaboliczne przemiany substancji przekaźnikowych u chorych z depresja endogenna.