Involvement of second messengers and protein phosphorylation in astrocyte swelling.
In a hypoosmotic model of astrocyte swelling, we found that Ca2+ and intracellular signals such as diacylglycerol and inositol phosphate, as well as protein phosphorylation systems, are implicated in the generation and (or) modulation of volume regulatory processes. Cyclic AMP, which also has a significant effect on astrocyte volume regulation, in addition influences some of these second messengers.
Bender
A S
AS
Laboratory of Neuropathology, Veterans Administration Medical Center, Miami, FL 33101.
Neary
J T
JT
Norenberg
M D
MD
D000818:Animals; D001253:Astrocytes / Q000502:physiology / Q000648:ultrastructure*; D006801:Humans; D009419:Nerve Tissue Proteins / Q000378:metabolism* / Q000502:physiology; D010766:Phosphorylation; D015290:Second Messenger Systems / Q000502:physiology*
D009419:Nerve Tissue Proteins