title: Facile and stereoselective synthesis of 2'-5'-oligothioadenylate by UO2(2+) ion catalyst.
abstract: The synthesis and characterization of 2'-5'-oligothioadenylate by UO2(2+) ion catalyst are described. The polymerization of imidazole-activated thioadenylate or thioinosylate yielded oligomers containing mainly 2'-5'-internucleotidyl blond and Rp configuration at phosphorous atom.
authors.affiliation: Department of Chemistry, Faculty of Engineering, Gunma University, Kiryu City, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Shimazu
authors.forename: K
authors.initials: K
authors.lastname: Shinozuka
authors.forename: H
authors.initials: H
authors.lastname: Sawai
mesh_terms: D000249:Adenosine Monophosphate / Q000031:analogs & derivatives* / Q000138:chemical synthesis; D002384:Catalysis; D009682:Magnetic Resonance Spectroscopy; D008968:Molecular Conformation; D013873:Thionucleotides / Q000138:chemical synthesis*; D014501:Uranium / Q000737:chemistry*; D017974:Uranium Compounds
chemical_list: D013873:Thionucleotides; D017974:Uranium Compounds; D000249:Adenosine Monophosphate; D014501:Uranium; C012597:uranium dioxide