[An experimental study of the tumor affinity of gallium-67-labelled sphingomyelin liposomes].
The level of accumulation of sphingomyelin liposomes with 67-Ga-labelled aqueous phase in tumor tissue proved higher than that of the vesicles with labelled lipid phase. Presence of cholesterol in sphingomyelin liposome membranes failed to influence liposome accumulation in tumor tissue. Neutral sphingomyelin vesicles with 67-Ga-labelled aqueous phase offer promise in scintigraphic imaging of tumors.
Kostenikov
N A
NA
Fadeev
N P
NP
Serzhanina
V A
VA
Koresakova
L N
LN
Rozenberg
O A
OA
D000818:Animals; D002784:Cholesterol / Q000008:administration & dosage / Q000493:pharmacokinetics; D004655:Emulsions; D005710:Gallium Radioisotopes; D008081:Liposomes; D008228:Lymphoma, Non-Hodgkin / Q000000981:diagnostic imaging / Q000378:metabolism*; D011877:Radionuclide Imaging; D051381:Rats; D013109:Sphingomyelins / Q000008:administration & dosage* / Q000493:pharmacokinetics; D013997:Time Factors; D014018:Tissue Distribution
D004655:Emulsions; D005710:Gallium Radioisotopes; D008081:Liposomes; D013109:Sphingomyelins; D002784:Cholesterol
Eksperimental'noe izuchenie tumorotropnosti sfingomielinovykh liposomom, mechennykh galliem-67.