Soluble factors levels in the initial staging of high-grade non-Hodgkin's lymphomas.
Plasma levels of several soluble factors were assayed in 31 untreated patients with high-grade non-Hodgkin's lymphomas (NHL). The results showed statistically significant higher average levels of interleukin-2 (IL-2), interleukin-6 (IL-6), interleukin-8 (IL-8), interleukin-2 receptor (IL-2r) and transferrin receptor (TF-r) in NHL patients compared to controls (p = 0.045, p = 0.047, p = 0.020, p = 0.026 and p = 0.033 respectively). IL-2, IL-2r and TF-r levels were found more elevated in Stages III/IV than in Stages I/II (p = 0.031, p = 0.016 and p = 0.048 respectively), whereas IL-6 concentrations were higher in patients presenting B symptoms (p = 0.011). Significant correlations were found between the erythrocyte sedimentation rate (ESR) and IL-6 (r = 0.681), and between beta 2 microglobulin (B2-m) and IL-2r (r = 0.622).
Stasi
R
R
Divisione di Ematologia, Università Tor Vergata, Ospedale S. Eugenio, Roma, Italy.
Conforti
M
M
Del Poeta
G
G
Simone
M D
MD
Coppetelli
U
U
Tribalto
M
M
Cantonetti
M
M
Perrotti
A
A
Venditti
A
A
Papa
G
G
D000328:Adult; D001799:Blood Sedimentation; D016207:Cytokines / Q000097:blood*; D005260:Female; D006801:Humans; D007770:L-Lactate Dehydrogenase / Q000097:blood; D016483:Lymphoma, AIDS-Related / Q000097:blood / Q000473:pathology; D008228:Lymphoma, Non-Hodgkin / Q000097:blood* / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D009363:Neoplasm Proteins / Q000097:blood; D009367:Neoplasm Staging; D011990:Receptors, Transferrin / Q000032:analysis*; D001613:beta 2-Microglobulin / Q000032:analysis
D016207:Cytokines; D009363:Neoplasm Proteins; D011990:Receptors, Transferrin; D001613:beta 2-Microglobulin; D007770:L-Lactate Dehydrogenase