[The role of polymorphonuclear leukocytes in the development of gastric lesions induced by indomethacin and ethanol and the relation of vascular permeability].
The relationship between a reduced number of polymorphonuclear leukocytes (PMN), activated PMN/NBT (+) PMN/, permeability of gastric vessels, and disposition for the development of gastric lesions was studied following administration of indomethacin or ethanol in rats. Decrease in the number of circulating neutrophils and in the number of NBT (+) PMN after 3- or 6-day administration of methotrexate was found to diminish the disposition for the development of gastric lesions. Six-day administration of pentoxifylline resulted in a decreased number of NBT (+) PMN and in a diminished disposition for gastric mucosa injury induced by indomethacin, yet failed to reduce the occurrence rate of lesions after ethanol administration. No direct relationship was established between changes in gastric vascular permeability and decreased disposition for the development of gastric lesions after administration of methotrexate or pentoxifylline. (Fig. 3, Ref. 30.)
Kohút
A
A
Ustav farmakológie LF UPJS, Kosiciach.
Mojzis
J
J
Sallingová
Z
Z
Mirossay
L
L
D000818:Animals; D002199:Capillary Permeability / Q000187:drug effects*; D000431:Ethanol / Q000633:toxicity*; D005260:Female; D005753:Gastric Mucosa / Q000098:blood supply* / Q000187:drug effects*; D007213:Indomethacin / Q000633:toxicity*; D007958:Leukocyte Count / Q000187:drug effects; D008297:Male; D008727:Methotrexate / Q000494:pharmacology; D009504:Neutrophils / Q000187:drug effects / Q000378:metabolism / Q000502:physiology*; D009580:Nitroblue Tetrazolium / Q000378:metabolism; D010431:Pentoxifylline / Q000494:pharmacology; D051381:Rats; D017208:Rats, Wistar
D009580:Nitroblue Tetrazolium; D000431:Ethanol; D010431:Pentoxifylline; D007213:Indomethacin; D008727:Methotrexate
Uloha polymorfonukleárnych leukocytov pri vzniku zalúdocných lézií vyvolaných indometacínom a etanolom vo vzt'ahu k cievnej permeabilite.