[The effect of tetrahydrofuran on the microsomal monooxygenase system in vitro and in vivo].
The effects of tetrahydrofuran (THF) on rat liver microsomes in vitro and in vivo were opposite. In vitro THF inhibited the p-nitrophenol (PNP) hydroxylase activity of microsomes from control rats and from rats treated with PB, acetone, and isoniazide--by 50, 20, 60, and 80%, respectively. THF inhibited dimethylnitrosamine (NDMA) demethylation in control and induced microsomes in a lesser degree. THF increased the total cytochrome P-450 content as well as the contents of cytochromes P-450IIE1 and P-450IIB1/B2. The activities of PNP-hydroxylation and NDMA-demethylation increased also, whereas the PR-dealkylation activity was unchanged. An increase in the THF dose caused inhibition of the rat liver microsomal monooxygenase system.
Kozlovskaia
N E
NE
Grishanova
A Iu
AIu
Mishin
V M
VM
Liakhovich
V V
VV
D000096:Acetone / Q000494:pharmacology; D000818:Animals; D004790:Enzyme Induction; D005663:Furans / Q000494:pharmacology*; D007538:Isoniazid / Q000494:pharmacology; D008297:Male; D008862:Microsomes, Liver / Q000187:drug effects* / Q000201:enzymology; D006899:Mixed Function Oxygenases / Q000037:antagonists & inhibitors / Q000096:biosynthesis / Q000378:metabolism*; D010634:Phenobarbital / Q000494:pharmacology; D051381:Rats; D017208:Rats, Wistar
D005663:Furans; D000096:Acetone; C018674:tetrahydrofuran; D006899:Mixed Function Oxygenases; D007538:Isoniazid; D010634:Phenobarbital
Vliianie tetragidrofurana na mikrosomnuiu mooksigenaznuiu sistemu in vitro i in vivo.