title: [Enteropathy in premature newborn infants. Prospective study over one year].
abstract: BACKGROUND
  In neonatal units, there is a tendency to assume that any acutely sick infant with gastro-intestinal symptoms has necrotizing enterocolitis (NEC). This prospective study was conducted to find a better definition of enteropathy in preterm neonates and their risk factors.
  
  
  METHODS
  All the 351 preterm neonates admitted to a neonatal unit from 1 August 1988 to 31 July 1989 were included in the study. A chart including 45 items was established for each infant, with special attention to data on the pregnancy, delivery, any early ischemic and/or infectious problem, nutrition and any gastro-intestinal (GI) problem. All the neonates were fed similarly, depending their maturation, gestational age and GI status. Each infant was assigned to one of 5 categories: 1) no GI problem; 2) transient obstruction; 3) NEC with pneumatosis; 4) hemorrhagic colitis without obstruction or pneumatosis; 5) other GI disease.
  
  
  RESULTS
  267 infants had no GI problem during their stay in the neonatal unit. 53 developed GI symptoms: 23 transient obstructions, 6 NEC, and 24 hemorrhagic colitis. The mean age at onset of symptoms in these last 3 categories was 7 days, 14 days and 23 days, respectively. Ten risk factors were found to be significantly correlated with GI disturbances: umbilical venous catheter, benzodiazepines, birth weight < 1,500 g, patent ductus arteriosus, ventilatory assistance, abnormal amniotic fluid, gestational age < 32 weeks, early antibiotic treatment, passage of meconium > 48 hours, episodes of apnoea and/or bradycardia.
  
  
  CONCLUSIONS
  This follow-up shows that the GI disturbances of preterm neonates admitted to a neonatal unit, specially those having one or more risk factors, can be separated into 3 groups: 1) isolated intestinal obstruction, seen in the most immature babies during the first week of life with the risk of developing NEC; 2) frank blood in the stool, indicating colitis and possibly minor forms of NEC; 3) combined obstructive and hemorrhagic symptoms, typical of NEC.
authors.affiliation: Département de Pédiatrie Médicale, Universitaire Gatien-de-Clocheville, Tours.
authors.forename: A L
authors.initials: AL
authors.lastname: Suc
authors.forename: M H
authors.initials: MH
authors.lastname: Blond
authors.forename: F
authors.initials: F
authors.lastname: Gold
authors.forename: C
authors.initials: C
authors.lastname: Maurage
authors.forename: E
authors.initials: E
authors.lastname: Saliba
authors.forename: M
authors.initials: M
authors.lastname: Guerois
authors.forename: J
authors.initials: J
authors.lastname: Laugier
mesh_terms: D004066:Digestive System Diseases / Q000175:diagnosis / Q000453:epidemiology; D004761:Enterocolitis, Pseudomembranous / Q000175:diagnosis / Q000453:epidemiology*; D005602:France / Q000453:epidemiology; D006801:Humans; D007231:Infant, Newborn; D007235:Infant, Premature, Diseases / Q000175:diagnosis / Q000453:epidemiology*; D011446:Prospective Studies; D012307:Risk Factors
vernacular_title: Entéropathie du nouveau-né prématuré. Etude prospective sur un an.