[The effect of bonnecor on blood coagulability and thrombocyte aggregation in transient myocardial ischemia].
The experiments on conscious rabbits have indicated that bonnecor given in doses of 0.05 mg/kg and 0.5 mg/kg accelerates clot formation and platelet aggregation, without changing the density of a thrombus. In experimental transient myocardial ischemia, the agent decreases the hypercoagulative change associated with the damaging effect of occlusion and reperfusion.
Denisova
S V
SV
Sapozhkov
A V
AV
D000818:Animals; D000889:Anti-Arrhythmia Agents / Q000494:pharmacology / Q000627:therapeutic use*; D001777:Blood Coagulation / Q000187:drug effects*; D003984:Dibenzazepines / Q000494:pharmacology / Q000627:therapeutic use*; D004305:Dose-Response Relationship, Drug; D004353:Drug Evaluation, Preclinical; D005260:Female; D008297:Male; D017202:Myocardial Ischemia / Q000097:blood / Q000188:drug therapy*; D010974:Platelet Aggregation / Q000187:drug effects*; D011817:Rabbits; D013997:Time Factors
D000889:Anti-Arrhythmia Agents; D003984:Dibenzazepines; C048166:tiracizine
Vliianie bonnekora na svertyvaemost' krovi i agregatsiiu trombotsitov v usloviiakh tranzitornoĭ ishemii miokarda.