Bioavailability and biological activity of L-ascorbic acid 2-O-alpha-glucoside.
AA-2G is a new stable derivative of AsA which is efficiently synthesized by regioselective transglucosylation with alpha-glucosidase and CGTase. AA-2G serves as a vitamin C supplement in experimental animals. AA-2G is easily hydrolyzed in vivo by alpha-glucosidase and also synthesized as a metabolite under some specified conditions. AA-2G stimulates collagen synthesis in cultured fibroblasts and enhances antibody production in cultured splenocytes. AA-2G which has no cytotoxicity is a promising AsA derivative for medical and nutritional uses.
Yamamoto
I
I
Department of Immunochemistry, Okayama University, Japan.
Muto
N
N
D000818:Animals; D001205:Ascorbic Acid / Q000031:analogs & derivatives* / Q000737:chemistry / Q000493:pharmacokinetics / Q000494:pharmacology; D001682:Biological Availability; D006031:Glycosylation; D006801:Humans
C065378:ascorbic acid 2-O-glucoside; D001205:Ascorbic Acid