[The effect of calcium antagonists on blood deoxygenation processes].
The effect of verapamil, nifedipine and sensit on the whole rat blood deoxygenation was studied by polarographic coulometry with consequent calculation of deoxygenation rate (DR) and blood deoxygenation constant (BDC). These drugs were studied in concentrations 10(-8)-10(-4) M according to their therapeutic range in vivo. Both verapamil and nifedipine significantly decreased DR, and the latter drug decreased BDC as well in concentration 2.9.10(-7) M. In contrast to verapamil and nifedipine, sensit caused mild, but statistically significant dose-related increase in DR with concomitant decrease in BDC. The data presented failed to establish relationships between chemical structure and deoxygenative effect of the drugs. Deoxygenation effect of sensit favours its administration in the treatment of ischemia-related arrhythmias.
Gatsura
S V
SV
Gukasov
V M
VM
D000818:Animals; D001769:Blood / Q000187:drug effects* / Q000378:metabolism; D002121:Calcium Channel Blockers / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D005275:Fendiline / Q000494:pharmacology; D009543:Nifedipine / Q000494:pharmacology; D010100:Oxygen / Q000097:blood*; D011048:Polarography / Q000379:methods; D051381:Rats; D014700:Verapamil / Q000494:pharmacology
D002121:Calcium Channel Blockers; D014700:Verapamil; D009543:Nifedipine; D005275:Fendiline; D010100:Oxygen
Vliianie antagonistov kal'tsiia na protsessy deoksigenatsii krovi.