[Fetal toxicity of non-steroidal anti-inflammatory agents].
All non-steroidal anti-inflammatory drugs (NSAIDs) are prostaglandin inhibitors, which explains their foetal toxicity. So far, no epidemiological study of their cardiopulmonary and renal effects has been carried out, but case-reports have been published. The cardiopulmonary effects of NSAIDs include closure of the ductus arteriosus, pulmonary hypertension cardiopathy and tricuspid valve insufficiency. They were responsible for 31 neonatal accidents, 8 of which were fatal (for 22 pregnant women, 7 bearing twins, 1 bearing triplets). The renal effects of NSAIDs consisted of acute renal failure with oedema, oliguria, hyponatraemia and marked hyperkalaemia. They affected 23 neonates, 8 of whom died (for 17 pregnant women, 4 bearing twins, 1 bearing triplets). A few epidemiological studies have reported foetal haemorrhages when aspirin was used by the mother as anti-inflammatory agent. In comparative trials of indomethacin as short treatment of premature labour and polyhydramnios the drug proved to be effective. In obstetrical tocolysis NSAIDs can be given in the absence of alternative therapy with beta-adrenergic agents, and their risk can be minimized by ultrasonographic examination and monitoring of foetal cardiac function and diuresis. In the field of rheumatology, corticosteroids would be a good alternative to NSAIDs for rheumatic diseases, but using NSAIDs for low back pain, sciatica, haemorrhoids, toothaches, sinusitis, etc., would not be justified in pregnant women. Self medication must be discouraged.
Bavoux
F
F
Centre de Pharmacovigilance, Hôpital Saint-Vincent-de-Paul, Paris.
D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000506:poisoning*; D005260:Female; D005315:Fetal Diseases / Q000139:chemically induced*; D006333:Heart Failure / Q000139:chemically induced; D006801:Humans; D007213:Indomethacin / Q000627:therapeutic use; D007231:Infant, Newborn; D007752:Obstetric Labor, Premature / Q000517:prevention & control; D011247:Pregnancy; D011453:Prostaglandins / Q000378:metabolism*; D051437:Renal Insufficiency / Q000139:chemically induced; D012127:Respiratory Distress Syndrome, Newborn / Q000139:chemically induced; D012307:Risk Factors
D000894:Anti-Inflammatory Agents, Non-Steroidal; D011453:Prostaglandins; D007213:Indomethacin
Toxicité foetale des anti-inflammatoires non stéroïdiens.