[Argyrophilic nucleolar organizer region proteins (Ag-NORs) in human central nervous tumors].
A silver colloid staining technique for identifying nucleolar organizer region-associated proteins (Ag-NORs) was applied to 17 primary gliomas and 16 meningiomas. These comprised 8 glioblastomas, one pleomorphic xanthoastrocytoma, 8 benign astrocytoma, 10 nonrecurrent meningiomas and 6 recurrent meningiomas, in which the mean number of Ag-NORs' per nuclei, were 3.37, 2.34, 2.57, 2.16 and 2.80 respectively, identifying significant differences among these groups. Ag-NORs of four giant cell glioblastomas showed low numbers of Ag-NORs, suggesting better prognosis. In spite of the time consuming and complicated counting method Ag-NORs is reproductive and useful as a tool for estimating the proliferating potential of various brain tumors, and appears to widely applicable in clinical laboratories.
Sawada
T
T
Pathology Division, Surugadai Nihon University Hospital, Tokyo.
Oinuma
T
T
Katada
H
H
Saitoh
M
M
Sakurai
I
I
D000293:Adolescent; D000328:Adult; D000368:Aged; D034961:Antigens, Nuclear; D016543:Central Nervous System Neoplasms / Q000473:pathology*; D002648:Child; D002675:Child, Preschool; D005260:Female; D005910:Glioma / Q000473:pathology*; D006651:Histocytochemistry; D006801:Humans; D008297:Male; D008577:Meningeal Neoplasms / Q000473:pathology*; D008579:Meningioma / Q000473:pathology*; D008875:Middle Aged; D009687:Nuclear Proteins / Q000032:analysis*; D009697:Nucleolus Organizer Region / Q000737:chemistry*; D011379:Prognosis; D012834:Silver; D013194:Staining and Labeling
D034961:Antigens, Nuclear; D009687:Nuclear Proteins; C051963:nucleolar organizer region associated proteins; D012834:Silver