Definition of a small chromosomal rearrangement on chromosome 11p14 by molecular cytogenetics in situ hybridization.
Chromosomal in situ hybridization allows the detection and the definition of single copy DNA segments of very small size. In a particular case, we demonstrate the inactivity of this molecular cytogenetic technique. In this case, karyotype analysis revealed a chromosome 11p+. In situ hybridization of probes PBGD, D11S29, NCAM, and ETSI located at 11q23-qter shows that the extra chromosomal material on chromosome 11p+ is a duplication of the 11q23-qter region.
Bérubé
D
D
Department of Human Genetics, Laval Medical Center, Ste-Foy, Quebec.
Gagné
R
R
D000015:Abnormalities, Multiple / Q000235:genetics; D002648:Child; D002871:Chromosome Banding; D002880:Chromosomes, Human, Pair 11 / Q000502:physiology*; D015321:Gene Rearrangement / Q000502:physiology*; D006801:Humans; D017403:In Situ Hybridization; D007621:Karyotyping