Morphological and electrophysiological changes of peripheral nerve-muscle unit in the aged rat prevented by levocarnitine acetyl.
The effects of levocarnitine acetyl on structure and function of the sciatic nerve and neuromuscular junctions of the soleus and extensor digitorum longus muscles were studied in the aged rat. To that end, neuromuscular conduction velocity (NMCV) was measured in vivo and morphological and morphometric evaluations were performed. Treatment with levocarnitine acetyl, 150 mg/kg day for six months, restored NMCV values to the levels measured in the young rat; significantly reduced the number of degenerating elements; and increased the number of myelinated fibres having normal structural features. In the soleus and extensor digitorum longus muscles, levocarnitine acetyl increased the complexity of neuromuscular junctions. These experimental findings suggest a neurotrophic action of levocarnitine acetyl on the peripheral nervous system that might have therapeutical applications in age-related peripheral nerve changes.
Scarfò
C
C
Institute for Research on Senescence, Sigma Tau S.p.A. Pomezia, Rome, Italy.
Falcinelli
M
M
Pacifici
L
L
Bellucci
A
A
Reda
E
E
De Angelis
C
C
Ramacci
M T
MT
Angelucci
L
L
D000108:Acetylcarnitine / Q000494:pharmacology*; D000375:Aging / Q000473:pathology* / Q000502:physiology; D000818:Animals; D008297:Male; D009412:Nerve Fibers / Q000473:pathology / Q000502:physiology; D009431:Neural Conduction / Q000187:drug effects; D009469:Neuromuscular Junction / Q000187:drug effects* / Q000473:pathology / Q000502:physiology; D010525:Peripheral Nerves / Q000187:drug effects* / Q000473:pathology / Q000502:physiology; D051381:Rats; D011916:Rats, Inbred F344
D000108:Acetylcarnitine