[Disorder of neuroendocrine regulation of sexual behavior of male rats with streptozotocin-induced diabetes].
The present paper presents studies of the sexual behavior characteristics and the associated changes of LH releasing factor and of sex hormone receptor concentrations in hypothalamic regions involved in the regulation of sexual behavior activity and hypophyseal gonadotropic function (the anterior preoptic and mediobasal regions) of rats with streptozotocin-induced diabetes. The activities of both motivational and copulative components of sex behavior of such rats were found reduced. These changes were parallelled by LH-RH reduction in the median eminence and in the synaptosomal fraction of the anterior preoptic and mediobasal regions. An increased concentration of estradiol nuclear receptors was found in the anterior preoptic region, that may be responsible for the male feminization in diabetes and for weaker male sexual activity parameters. Blood levels of LH and FSH in experimental rats were virtually the same as in the reference animals, whereas prolactin and testosterone levels were reduced in the presence of elevated estradiol content. The majority of the detected hormonal shifts and sexual behavior characteristics normalized after compensatory insulin therapy. The authors come to a conclusion on the neuroendocrine disorders at the level of the CNS in animals with experimental diabetes during the formation of the motivational and copulative components of sexual behavior.
El'tseva
T V
TV
Adamskaia
E I
EI
Peryshkova
T A
TA
Babichev
V N
VN
D000818:Animals; D003921:Diabetes Mellitus, Experimental / Q000097:blood / Q000378:metabolism* / Q000523:psychology; D005640:Follicle Stimulating Hormone / Q000097:blood; D007987:Gonadotropin-Releasing Hormone / Q000378:metabolism*; D007031:Hypothalamus / Q000378:metabolism*; D007986:Luteinizing Hormone / Q000097:blood; D008297:Male; D051381:Rats; D011987:Receptors, Steroid / Q000378:metabolism*; D012726:Sexual Behavior, Animal / Q000502:physiology*
D011987:Receptors, Steroid; D007987:Gonadotropin-Releasing Hormone; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone
Narushenie neĭroéndokrinnoĭ reguliatsii polovogo povedeniia samtsov krys so streptozototsinovym diabetom.