title: [Masked Philadelphia chromosome: diagnostic implications in a case of chronic myeloid leukemia presenting in blast crisis].
abstract: We present a female patient with acute non-lymphoblastic leukemia (ANLL) and with haematologic features suggestive of its evolution from chronic myeloid leukaemia (CML), in which a bone marrow karyotype showing a "masked" Philadelphia (Ph) chromosome due to a variant translocation of complex type t(9;9;22)(q32;q34;q11) was found. We comment the peculiarities of this special Ph chromosome as well as the differential diagnostic problems between ANLL Ph(+) and CML with onset in blastic crisis.
authors.affiliation: Servicio de Citogenética, Facultad de Medicina, Universidad de la Laguna, Tenerife, Islas Canarias, España.
authors.forename: J L
authors.initials: JL
authors.lastname: Carrasco
authors.forename: M T
authors.initials: MT
authors.lastname: Hernández García
authors.forename: A
authors.initials: A
authors.lastname: Otero
authors.forename: M C
authors.initials: MC
authors.lastname: Vilar
authors.forename: L
authors.initials: L
authors.lastname: Marsá
authors.forename: G
authors.initials: G
authors.lastname: González Brito
authors.forename: J L
authors.initials: JL
authors.lastname: García Miranda
authors.forename: L
authors.initials: L
authors.lastname: Hernández Nieto
mesh_terms: D000368:Aged; D001752:Blast Crisis / Q000175:diagnosis* / Q000473:pathology; D002892:Chromosomes, Human, Pair 22 / Q000648:ultrastructure; D002899:Chromosomes, Human, Pair 9 / Q000648:ultrastructure; D003937:Diagnosis, Differential; D005188:False Negative Reactions; D005260:Female; D015321:Gene Rearrangement; D006801:Humans; D007621:Karyotyping; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000175:diagnosis* / Q000473:pathology; D015470:Leukemia, Myeloid, Acute / Q000175:diagnosis*; D008957:Models, Genetic; D010677:Philadelphia Chromosome; D014178:Translocation, Genetic
vernacular_title: Cromosoma Filadelfia enmascarado: implicaciones diagnósticas en un caso de leucemia mieloide crónica de presentación en crisis blástica.