[Studies on the establishment of malarial animal model of short-term relapse. II. The phenomenon of sustained special ring form parasitemia in Plasmodium cynomolgi infection].
Our previous report that the EE merozites of Plasmodium cynomolgi from Vietnam continuously released from the liver to the blood circulation was further demonstrated in this report. Monkeys were given pyronaridine 24 mg/kg.d x 6 after being inoculated intravenously with 32 x 10(5) sporzoites of P. cynomolgi. Thick blood film examination was conducted two times daily till the day when trophozoites were detected. Under the residual action of blood schizontocied, a special ring form parasitemia at low patasite-density was detected for more than 30 days. As the ring forms of P. cynomolgi were demonstrated to be susceptible to pyronaridine in our previous experiments, it might be inferred that these ring forms derived from EE merozites released not for once but continuously for 30 days or longer.
Zhang
J X
JX
Institute of Parasitic Diseases, Chinese Academy of Preventive Medicine, Shanghai.
Lin
B Y
BY
Pan
Y R
YR
Zheng
H
H
Fang
Y
Y
D000634:Aminoquinolines / Q000627:therapeutic use; D000818:Animals; D000962:Antimalarials / Q000627:therapeutic use; D004195:Disease Models, Animal; D008253:Macaca mulatta; D008288:Malaria / Q000188:drug therapy*; D009287:Naphthyridines / Q000627:therapeutic use; D016789:Plasmodium cynomolgi; D012008:Recurrence
D000634:Aminoquinolines; D000962:Antimalarials; D009287:Naphthyridines; C015773:dabequin; C027871:pyronaridine