[Relations between HDL-cholesterol and cardiovascular diseases].
Many retrospective and prospective epidemiological studies have demonstrated an inverse relationship between HDL-cholesterol and coronary risk. The predictive value of HDL-cholesterol is observed both in asymptomatic subjects and those with a primary vascular event. Several genetic abnormalities may be responsible for low HDL cholesterol (under 100 mg/dl or 0.26 mmol/l) or for a less severe hypoalphalipoproteinaemia. Despite some very low values, these rare causes of HDL deficiency are not all atherogenic and serve to emphasize the complexity of HDL metabolism. The protective role of HDL is explained by a number of mechanisms such as their role in the reverse transport from the peripheral tissues to the liver, their anti-oxidant effect and the increase in prostacyclin levels. The correction of isolated hypoalphalipoproteinaemia by drugs is controversial, but associated hyperlipidaemic states would be an indication to use drugs which increase the HDl-cholesterol the most.
Emmerich
J
J
Service de pathologie vasculaire, hôpital Broussais, Paris.
Bruckert
E
E
Delahaye
F
F
Thomas
D
D
Richard
J L
JL
D016632:Apolipoprotein A-I / Q000032:analysis; D008076:Cholesterol, HDL / Q000097:blood* / Q000378:metabolism; D017023:Coronary Angiography; D003327:Coronary Disease / Q000097:blood* / Q000453:epidemiology / Q000517:prevention & control; D005260:Female; D006801:Humans; D007009:Hypolipoproteinemias / Q000235:genetics; D008297:Male; D015999:Multivariate Analysis; D011237:Predictive Value of Tests; D012306:Risk
D016632:Apolipoprotein A-I; D008076:Cholesterol, HDL
Relation entre HDL-cholestérol et maladies cardiovasculaires.