title: [Pancreatic endocrine tumor with metastases and increase of alpha-fetoprotein. A case report].
abstract: The authors report the case of a 48 years old man presenting a pancreatic islet cell carcinoma (gastrinoma) with liver, nodes and peritoneal metastases, associated with an elevated alpha-fetoprotein (AFP) concentration. Incomplete remission was first obtained with a chemotherapy using Streptozotocin combined with 5-Fluorouracil, in association with a Somatostatin analogue (SMS 201-995). But when relapses occur, another chemotherapy was not so effective. Serum gastrin and AFP levels had the same evolution and appear to have the same interest to follow the course of the disease.
authors.affiliation: Service de Médecine Interne, Hôpital Pitié-Salpêtrière, Paris.
authors.forename: F
authors.initials: F
authors.lastname: Congy
authors.forename: S
authors.initials: S
authors.lastname: Pelletier
authors.forename: P
authors.initials: P
authors.lastname: Langlois
authors.forename: D
authors.initials: D
authors.lastname: Khayat
authors.forename: T
authors.initials: T
authors.lastname: Homsi
authors.forename: J
authors.initials: J
authors.lastname: Emerit
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D001706:Biopsy; D017809:Fatal Outcome; D005472:Fluorouracil / Q000008:administration & dosage; D015408:Gastrinoma / Q000097:blood* / Q000188:drug therapy / Q000556:secondary*; D005755:Gastrins / Q000097:blood; D006801:Humans; D008113:Liver Neoplasms / Q000097:blood* / Q000188:drug therapy / Q000556:secondary*; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D015282:Octreotide / Q000008:administration & dosage; D010190:Pancreatic Neoplasms / Q000473:pathology*; D010534:Peritoneal Neoplasms / Q000097:blood* / Q000188:drug therapy / Q000556:secondary*; D012074:Remission Induction; D013311:Streptozocin / Q000008:administration & dosage; D000509:alpha-Fetoproteins / Q000032:analysis*
chemical_list: D005755:Gastrins; D000509:alpha-Fetoproteins; D013311:Streptozocin; D015282:Octreotide; D005472:Fluorouracil
vernacular_title: Tumeur endocrine pancréatique avec métastases et élévation de l'alpha-foetoprotéine. A propos d'un cas.