[The role of the hemopoiesis-inducing microenvironment in the mechanisms of the regeneration of hemopoiesis after cytostatic exposure].
On the model of adriamycine-induced hemopoiesis hypoplasia it has been shown that the accelerated differentiation of hemopoietic precursors regeneration is of great importance in regeneration of hemopoiesis. This differentiation is provided by preceded recovery of bone marrow structural-functional organization. The important role in regeneration of hemopoiesis belongs to hemopoietic microenvironmental elements which express its induced influence by the increase of colony-stimulating and erythropoietic activities, interleukin-1 and interleukin-3 production.
Dygaĭ
A M
AM
Zhadanov
V V
VV
Bogdashin
I V
IV
Gol'dberg
V E
VE
D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology*; D001853:Bone Marrow / Q000187:drug effects / Q000378:metabolism; D001854:Bone Marrow Cells; D003114:Colony-Forming Units Assay; D016207:Cytokines / Q000378:metabolism; D004317:Doxorubicin / Q000494:pharmacology; D006410:Hematopoiesis / Q000187:drug effects*; D006412:Hematopoietic Stem Cells / Q000166:cytology / Q000187:drug effects*; D008297:Male; D051379:Mice; D008808:Mice, Inbred CBA; D013997:Time Factors
D000970:Antineoplastic Agents; D016207:Cytokines; D004317:Doxorubicin
Rol' gemopoézindutsiruiushchego mikrookruzheniia v mekhanizmakh regeneratsii krovetvoreniia posle tsitostaticheskogo vozdeĭstviia.