title: Effects of buprenorphine on respiratory and cardiovascular functions during hypoxia in anaesthetized rabbits.
abstract: Respiratory and cardiovascular variables were studied in 10 anaesthetized rabbits, before and after buprenorphine i.v. injections (cumulative doses of 5 to 100 micrograms/kg). In normoxic conditions, buprenorphine induced hypoventilation, due to a decrease in respiratory rate, and bradycardia: mean maximum modifications in ventilation (-17%) and heart rate (-7%) were obtained with buprenorphine 10 and 100 micrograms/kg, respectively. Isocapnic hypoxia, produced by the inhalation of a gas mixture containing 10% O2 in nitrogen for 5 min, provoked a mean 44% increase in base line ventilation and a mean 15% decrease in heart rate. The ventilatory response to hypoxia was not significantly modified by buprenorphine on an average; large decreases in hypoxic drive could still be observed in 3 out of 10 animals with buprenorphine 5 and 10 micrograms/kg. Buprenorphine enhanced hypoxia-induced bradycardia: a mean maximum decrease in heart rate (-29%) was reached with 10 micrograms/kg of this opioid.
authors.affiliation: Laboratoire de Physiologie Respiratoire, Faculté de Médecine, Marseille, France.
authors.forename: S
authors.initials: S
authors.lastname: Delpierre
authors.forename: P
authors.initials: P
authors.lastname: Vanuxem
mesh_terms: D000758:Anesthesia; D000818:Animals; D002047:Buprenorphine / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D006339:Heart Rate / Q000187:drug effects; D006439:Hemodynamics / Q000187:drug effects*; D000860:Hypoxia / Q000503:physiopathology*; D011817:Rabbits; D012119:Respiration / Q000187:drug effects*; D012129:Respiratory Function Tests
chemical_list: D002047:Buprenorphine