title: Some characteristics of serum phenytoin concentration, in black Zimbabwean volunteers.
abstract: A study of phenytoin pharmacokinetics in 15 black healthy Zimbabwean volunteers with an average age of 22 to 44 years was performed. A dose of 200 mg (capsules) sodium phenytoin was administered orally to each subject. Peak phenytoin serum levels were detected six hours post-dosing at 2.98 +/- 0.53 micrograms/ml. The mean elimination half life (t1/2) was calculated at 40.2 hours with a range of 36.7 to 40.5 hours. The area under the curve was calculated to be 142.5 with a range of 118 to 192. Comparison of our results with those obtained by other workers is discussed.
authors.affiliation: Clinical Pharmacology Department, University of Zimbabwe, School of Medicine, Avondale, Harare.
authors.forename: C F
authors.initials: CF
authors.lastname: Nhachi
authors.forename: G M
authors.initials: GM
authors.lastname: Mwaluko
mesh_terms: D000284:Administration, Oral; D000328:Adult; D044383:Black People / Q000235:genetics; D001835:Body Weight; D016903:Drug Monitoring; D005260:Female; D006801:Humans; D008111:Liver Function Tests; D008297:Male; D010672:Phenytoin / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics*; D012016:Reference Values; D013997:Time Factors; D015030:Zimbabwe
chemical_list: D010672:Phenytoin