[The metabolism and biological activity of glucuronidation substrates in experimental diabetes mellitus].
The study was undertaken to examine the impact of experimental diabetes mellitus on the biotransformation of some drugs, their toxicity and hypoglycemic action, as well as on the biotransformation of endogenous testosterone and the androgenic status. The accelerated metabolism of both exogenous and endogenous substrates which occurred in diabetes mellitus caused a decrease in their biological activity.
Krylov
Iu F
IuF
Smirnov
P A
PA
Flerovskiĭ
A A
AA
D000818:Animals; D001711:Biotransformation; D001786:Blood Glucose / Q000378:metabolism; D003921:Diabetes Mellitus, Experimental / Q000378:metabolism*; D004305:Dose-Response Relationship, Drug; D005965:Glucuronates / Q000378:metabolism*; D008297:Male; D051379:Mice; D020113:Phenolphthalein; D010635:Phenolphthaleins / Q000493:pharmacokinetics; D051381:Rats; D017208:Rats, Wistar; D013739:Testosterone / Q000378:metabolism; D013997:Time Factors; D015262:Xenobiotics / Q000493:pharmacokinetics*
D001786:Blood Glucose; D005965:Glucuronates; D010635:Phenolphthaleins; D015262:Xenobiotics; D013739:Testosterone; D020113:Phenolphthalein
Metabolizm i biologicheskaia aktivnost' substratov gliukuronidirovaniia pri éksperimental'nom sakharnom diabete.