title: [The humoral immunity indices of patients with malignant skin melanoma using the viral immunomodulator rigvir].
abstract: The effect of a viral immunomodulator rigvir on humoral immunity was studied in patients with skin malignant melanoma. Peripheral blood levels of B-lymphocytes, IgA, G and M and circulating immune complexes were assayed and immunoglobulin/B-cell ratio (Ig/B) calculated. Preoperative treatment with rigvir brought the indexes of humoral immunity to normal. Response of melanoma patients to rigvir treatment was different from that seen in healthy subjects and was determined by the course of disease.
authors.forename: L S
authors.initials: LS
authors.lastname: Glinkina
authors.forename: O G
authors.initials: OG
authors.lastname: Heisele
authors.forename: R R
authors.initials: RR
authors.lastname: Garklava
authors.forename: A J
authors.initials: AJ
authors.lastname: Muceniece
mesh_terms: D000276:Adjuvants, Immunologic / Q000627:therapeutic use*; D000328:Adult; D000368:Aged; D000917:Antibody Formation / Q000187:drug effects; D000936:Antigen-Antibody Complex / Q000097:blood / Q000187:drug effects; D001402:B-Lymphocytes / Q000187:drug effects / Q000276:immunology; D004341:Drug Evaluation; D029822:Enterovirus B, Human / Q000276:immunology*; D005260:Female; D006801:Humans; D008297:Male; D008545:Melanoma / Q000188:drug therapy* / Q000276:immunology; D008875:Middle Aged; D012878:Skin Neoplasms / Q000188:drug therapy* / Q000276:immunology; D013997:Time Factors
chemical_list: D000276:Adjuvants, Immunologic; D000936:Antigen-Antibody Complex
vernacular_title: Pokazateli gumoral'nogo immuniteta u bol'nykh zlokachestvennoĭ melanomoĭ kozhi pri primenenii virusnogo immunomoduliatora rigvira.