title: Kallmann syndrome gene on the X and Y chromosomes: implications for evolutionary divergence of human sex chromosomes.
abstract: The recently identified gene for X-linked Kallmann syndrome (hypogonadotropic hypogonadism and anosmia) has a closely related homologue on the Y chromosome. The X and Y copies of this gene are located in a large region of X/Y homology, on Xp22.3 and Yq11.2, respectively. Comparison of the structure of the X-linked Kallmann syndrome gene and its Y homologue shed light on the evolutionary history of this region of the human sex chromosomes. Our data show that the Y homologue is not functional. Comparative analysis of X/Y sequence identity at several loci on Xp22.3 and Yq11.2 suggests that the homology between these two regions is the result of a complex series of events which occurred in the recent evolution of sex chromosomes.
authors.affiliation: Institute for Molecular Genetics, Baylor College of Medicine, Houston, Texas 77030.
authors.forename: B
authors.initials: B
authors.lastname: Incerti
authors.forename: S
authors.initials: S
authors.lastname: Guioli
authors.forename: A
authors.initials: A
authors.lastname: Pragliola
authors.forename: E
authors.initials: E
authors.lastname: Zanaria
authors.forename: G
authors.initials: G
authors.lastname: Borsani
authors.forename: R
authors.initials: R
authors.lastname: Tonlorenzi
authors.forename: B
authors.initials: B
authors.lastname: Bardoni
authors.forename: B
authors.initials: B
authors.lastname: Franco
authors.forename: D
authors.initials: D
authors.lastname: Wheeler
authors.forename: A
authors.initials: A
authors.lastname: Ballabio
mesh_terms: D001483:Base Sequence; D005075:Biological Evolution; D002874:Chromosome Mapping; D004247:DNA / Q000235:genetics; D005091:Exons; D006801:Humans; D017436:Kallmann Syndrome / Q000235:genetics*; D008297:Male; D008969:Molecular Sequence Data; D012689:Sequence Homology, Nucleic Acid; D014960:X Chromosome; D014998:Y Chromosome
chemical_list: D004247:DNA