Tryptophan and serotonin metabolism in familial erythrophagocytic lymphohistiocytosis.
Reduced concentrations of tryptophan and 5-hydroxyindoleacetic acid (the major CSF metabolite of serotonin) were found in the cerebrospinal fluid of two children with familial erythrophagocytic lymphohistiocytosis. This was associated with elevated cerebrospinal fluid neopterin concentrations indicating increased macrophage activity within the central nervous system. In one child, cytotoxic therapy induced a complete clinical remission and an increase of tryptophan and 5-hydroxyindoleacetic acid concentrations to normal; during a subsequent relapse, concentrations of these analytes again fell below normal. In the other child, in whom therapy produced only a transient improvement, tryptophan and 5-hydroxyindoleacetic acid concentrations remained low and the child died. It is likely that increased activity of indoleamine 2,3-dioxygenase induced by the activation of macrophages was responsible for the disturbance in serotonin and tryptophan homeostasis within the brain. Excessive tryptophan catabolism and the disturbance of serotonin turnover may play a role in the aetiology of the neurological symptoms seen in familial erythrophagocytic lymphohistiocytosis.
Howells
D W
DW
Department of Child Health, Institute of Child Health, London, UK.
Hyland
K
K
Smith
I
I
Strobel
S
S
D000375:Aging / Q000378:metabolism; D000596:Amino Acids / Q000134:cerebrospinal fluid; D001708:Biopterins / Q000031:analogs & derivatives / Q000134:cerebrospinal fluid; D002675:Child, Preschool; D005047:Etoposide / Q000627:therapeutic use; D015616:Histiocytosis, Non-Langerhans-Cell / Q000134:cerebrospinal fluid* / Q000188:drug therapy / Q000235:genetics; D006719:Homovanillic Acid / Q000134:cerebrospinal fluid; D006801:Humans; D006897:Hydroxyindoleacetic Acid / Q000134:cerebrospinal fluid; D007223:Infant; D008297:Male; D008727:Methotrexate / Q000627:therapeutic use; D019798:Neopterin; D011239:Prednisolone / Q000627:therapeutic use; D012701:Serotonin / Q000134:cerebrospinal fluid*; D014364:Tryptophan / Q000134:cerebrospinal fluid*
D000596:Amino Acids; D001708:Biopterins; D012701:Serotonin; D006897:Hydroxyindoleacetic Acid; D019798:Neopterin; D005047:Etoposide; D014364:Tryptophan; D011239:Prednisolone; D006719:Homovanillic Acid; D008727:Methotrexate