title: Age-related changes in the levels of IgG, IgM and IgA antibodies to type I collagen in the sera of normal human subjects.
abstract: Serum samples from healthy subjects of different ages (within the age range of 1-75 years) were tested for the presence of anti-type I collagen (anti-CI) IgG, IgM and IgA by enzyme-linked immunosorbent assay (ELISA). All the tested sera showed anti-CI antibodies from the three immunoglobulin classes with the following age-related regularities: 1. Anti-CI IgG and IgM showed statistically non-significant changes up to the age of 60 decreasing thereafter. 2. Anti-Ci IgA changed negligibly up to the age of 40 increasing with age thereafter. The established age-related changes in the levels of anti-CI antibodies may serve as a basis for future studies of normal and pathological turnover of type I collagen.
authors.affiliation: Department of Biology, Medical University, Pleven, Bulgaria.
authors.forename: G
authors.initials: G
authors.lastname: Nicoloff
authors.forename: D
authors.initials: D
authors.lastname: Valtsova
authors.forename: S
authors.initials: S
authors.lastname: Baydanoff
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000375:Aging / Q000276:immunology*; D000818:Animals; D001323:Autoantibodies / Q000032:analysis*; D002648:Child; D002675:Child, Preschool; D003094:Collagen / Q000276:immunology*; D004591:Electrophoresis, Polyacrylamide Gel; D004797:Enzyme-Linked Immunosorbent Assay; D006801:Humans; D015151:Immunoblotting; D007070:Immunoglobulin A / Q000032:analysis; D007074:Immunoglobulin G / Q000032:analysis; D007075:Immunoglobulin M / Q000032:analysis; D007136:Immunoglobulins / Q000032:analysis*; D007223:Infant; D008875:Middle Aged; D012756:Sheep
chemical_list: D001323:Autoantibodies; D007070:Immunoglobulin A; D007074:Immunoglobulin G; D007075:Immunoglobulin M; D007136:Immunoglobulins; D003094:Collagen