title: Direct immunofluorescence testing for immunoglobulin deposits in haired skin, nasal planum and footpads of woodchuck hepatitis virus-infected woodchucks with chronic hepatitis and multiple hepatocellular carcinomas.
abstract: The purpose of this study was to determine the frequency of immunoglobulin deposition in the haired skin, footpads, and nasal planums of 10 WHV-infected woodchucks with chronic hepatitis and hepatocellular carcinoma and compare these results with those reported in humans. Immunoglobulin deposition was detected in the skin samples of 3 of 10 woodchucks. Granular deposits were revealed in the superficial dermal blood vessels of the nasal planum, lateral thoracic skin, and footpads in 1 animal each. In 1 of these animals, (lateral thorax) immunoglobulin deposition was concurrently present at the basement membrane zone.
authors.affiliation: Department of Clinical Sciences, New York State College of Veterinary Medicine, Cornell University, Ithaca 14853.
authors.forename: R
authors.initials: R
authors.lastname: Panić
authors.forename: D W
authors.initials: DW
authors.lastname: Scott
authors.forename: C A
authors.initials: CA
authors.lastname: Smith
authors.forename: B C
authors.initials: BC
authors.lastname: Tennant
mesh_terms: D000818:Animals; D001707:Biopsy, Needle; D006528:Carcinoma, Hepatocellular / Q000150:complications / Q000276:immunology; D002908:Chronic Disease; D004195:Disease Models, Animal; D005260:Female; D005455:Fluorescent Antibody Technique; D005528:Foot; D006197:Hair; D015613:Hepadnaviridae; D006524:Hepatitis, Viral, Animal / Q000150:complications / Q000276:immunology*; D007136:Immunoglobulins / Q000032:analysis*; D008113:Liver Neoplasms / Q000150:complications / Q000276:immunology; D008297:Male; D008392:Marmota; D009666:Nose; D012867:Skin / Q000276:immunology*
chemical_list: D007136:Immunoglobulins