[The effect of nitrogen-containing derivatives of 1,4-naphthoquinone on mitochondrial lipid peroxidation].
Nitrogen-containing derivatives of 1,4-naphthoquinone synthesized in the form of donor-acceptor autocomplexes, may serve as highly effective antioxidative agents exhibiting their properties both in microheterogeneous medium (water-micellar Tween 80 solution) and in enzymatic and nonenzymatic oxidation of lipids in mitochondria. Some of these complexes studied, where intramolecular transfer of a charge occurred during nonenzymatic oxidation in mitochondria, were only slightly less effective in the antioxidant activity as compared with the standard antioxidant ionol. Distinct increase in the antioxidant activity of the most substances studied was detected in presence of reductases participating in mitochondrial chains of electron transfer and two of these drugs proved to be more effective as compared with menadione and ionol. The data obtained are of importance for pharmacological prognosis of these new biologically active substances efficiency.
Shneĭvaĭs
V B
VB
Drulle
A Ia
AIa
Dregeris
Ia Ia
IaIa
Levin
G S
GS
D000818:Animals; D004579:Electron Transport; D015227:Lipid Peroxidation; D008930:Mitochondria, Liver / Q000187:drug effects* / Q000378:metabolism; D009249:NADP / Q000378:metabolism; D009285:Naphthoquinones / Q000737:chemistry / Q000494:pharmacology*; D009584:Nitrogen / Q000032:analysis*; D051381:Rats
D009285:Naphthoquinones; D009249:NADP; D009584:Nitrogen; C035342:1,4-naphthoquinone
Vliinie azotsoderzhashchikh proizvodnykh 1,4-naftokhinona na perekisnoe okislenie lipidov mitokhondriĭ.