[Hemodynamic effects of antihypertensive drugs on pregnancy-induced hypertension].
Aiming to select a proper kind of antihypertensive drug for mild and moderate pregnancy-induced hypertension (PIH), 30 patients with PIH were examined by using noninvasive cardiovascular detector TP-CBS. The basic hemodynamic parameters included mean artery pressure (MAP) Kpa, heart rate (HR) bpm, cardiac index (CI) L min-1/m2 and total peripheral resistance (TPR) PRU. The 30 cases were divided into 6 groups with 5 each to take a single dose of prazoxin, phentolamine, methyldopa, captopril, nifedipine and aminophylline respectively. Hemodynamic parameters were examined consecutively every 30 minutes for 4 hours after ingesting the above drugs. The results showed that all the 6 medicines had effects of lowering MAP and TPR without change of cardiac output. Nevertheless, viewing from the effect of lowering blood pressure, change of pulse rate, time of action and incidence of side effects, we considered that nifedipine is superior to the other 5 and can be preferably recommended at outpatient clinic.
Cong
K J
KJ
Beijing Obstetrics and Gynecol Hospital.
D000959:Antihypertensive Agents / Q000494:pharmacology / Q000627:therapeutic use*; D005260:Female; D006439:Hemodynamics / Q000187:drug effects*; D006801:Humans; D009543:Nifedipine / Q000494:pharmacology / Q000627:therapeutic use*; D011225:Pre-Eclampsia / Q000188:drug therapy* / Q000503:physiopathology*; D011247:Pregnancy
D000959:Antihypertensive Agents; D009543:Nifedipine