[Lethal effect of boron neutron capture reaction on human uveal melanoma cells in culture incubated with borophenylalanine].
Cell cultures obtained from human uveal tumours have been used as experimental model to study the lethal effect consecutive to the neutron capture reaction on boron incorporated into cells as borophenylalanine. An irradiation with a neutron fluence of 6 x 10(9) n cm-2 reduced the number of viable cells by about 30%.
Belkhou
R
R
Centre de Recherches nucléaires, Strasbourg.
Mykita
S
S
Meyer
L
L
Sahel
J
J
Abbé
J C
JC
Dreyfus
H
H
Massarelli
R
R
D001896:Boron Compounds / Q000378:metabolism; D016754:Boron Neutron Capture Therapy; D016923:Cell Death / Q000528:radiation effects; D003470:Culture Media; D006801:Humans; D008545:Melanoma / Q000378:metabolism* / Q000473:pathology / Q000532:radiotherapy*; D010649:Phenylalanine / Q000378:metabolism; D014407:Tumor Cells, Cultured / Q000528:radiation effects; D014604:Uveal Neoplasms / Q000378:metabolism* / Q000473:pathology / Q000532:radiotherapy*
D001896:Boron Compounds; D003470:Culture Media; D010649:Phenylalanine
Effet létal de la réaction de capture neutronique du bore sur des cellules de mélanome uvéal humain en culture incubées avec la boro-phénylalanine.