title: Hepatosplenic infection caused by Candida parapsilosis in patients with acute leukemia.
abstract: Candida parapsilosis is an exceptional agent in hepatosplenic candidosis. Here we report two cases of hepatosplenic infection caused by Candida parapsilosis in two patients with acute leukaemia. Open liver-spleen biopsy and previously minimal exposure to systemic antifungal drugs led to a cultural diagnosis in both patients. This report confirms the importance of an early diagnosis of these diseases in order to undertake appropriate therapeutic regimens.
authors.affiliation: Laboratorio di Microbiologia Clinica-Università degli Studi G. D'Annunzio, Chieti, Italy.
authors.forename: D
authors.initials: D
authors.lastname: D'Antonio
authors.forename: G
authors.initials: G
authors.lastname: Fioritoni
authors.forename: A
authors.initials: A
authors.lastname: Iacone
authors.forename: S
authors.initials: S
authors.lastname: Betti
authors.forename: P
authors.initials: P
authors.lastname: Fazii
authors.forename: M
authors.initials: M
authors.lastname: Dell'Isola
authors.forename: R
authors.initials: R
authors.lastname: Di Gianfilippo
authors.forename: A
authors.initials: A
authors.lastname: Di Silverio
authors.forename: S
authors.initials: S
authors.lastname: Ubezio
authors.forename: C
authors.initials: C
authors.lastname: Zeccara
mesh_terms: D000328:Adult; D002177:Candidiasis / Q000150:complications*; D002648:Child; D005260:Female; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000150:complications*; D008107:Liver Diseases / Q000150:complications* / Q000382:microbiology; D008297:Male; D013158:Splenic Diseases / Q000150:complications* / Q000382:microbiology