[Clinical formulations of amphotericin B].
The clinical use of amphotericin B is impaired by its poor water solubility and by the severity of its side effects. Several amphotericin B formulations have already been prepared in an attempt to overcome these disadvantages. The following methods have been proposed to solubilize amphotericin B in water: the complexation of amphotericin B with metallic ions, sodium tetraborate or gamma cyclodextrin or the synthesis of semi-synthetic derivatives. Another approach was to use a carrier (liposomes, lipoproteins, emulsions or surfactants) to target amphotericin B. This paper summarizes and criticizes these formulations.
Tasset
C
C
Laboratoire de Pharmacie Galénique, Bruxelles, Belgique.
Preat
V
V
Roland
M
M
D000666:Amphotericin B / Q000008:administration & dosage* / Q000737:chemistry; D004337:Drug Carriers; D012996:Solutions
D004337:Drug Carriers; D012996:Solutions; D000666:Amphotericin B
Formulations galéniques d'amphotéricine B.