[Contribution of chemiluminescence for determination of low value TSH in patients with dysthyroidism during negative TRH test].
TSH values performed by immunoradiometric method were compared with chemiluminescent method in 28 hyperthyroid patients with negative TRH-test. This last method gives a better sensitivity (0.020 mUI/L vs. 0.050 mUI/L) and reproducibility (5% V.C. vs. 40%). The measure of undetectable TSH by immunoradiometric assay becomes possible with chemiluminescence. Due to this increase of sensitivity, the TRH-test needs to be reconsidered and allows to discriminate various degrees of TSH suppression.
Caillot
A
A
Laboratoire de Médecine Nucléaire, CHRU de Saint Etienne, Hôpital Bellevue, Saint Etienne.
Vindimian
M
M
Estour
B
B
Soler
C
C
Delabre
S
S
Blanc
L
L
Peng
J
J
Rousset
H
H
Healy
J C
JC
D000328:Adult; D000368:Aged; D005260:Female; D006801:Humans; D015592:Immunoradiometric Assay; D008163:Luminescent Measurements; D008297:Male; D008875:Middle Aged; D015203:Reproducibility of Results; D013959:Thyroid Diseases / Q000097:blood*; D013972:Thyrotropin / Q000097:blood*; D013973:Thyrotropin-Releasing Hormone
D013973:Thyrotropin-Releasing Hormone; D013972:Thyrotropin
Apport de la chimiluminescence au dosage de valeurs basses de TSH chez des patients souffrant de dysthyroïdie lors de test à la TRH non répondant.