title: Russuphelin A, a new cytotoxic substance from the mushroom Russula subnigricans Hongo.
abstract: A new cytotoxic substance, designated russuphelin A (1), has been isolated from the mushroom Russula subnigricans Hongo (Basidiomycetes). The structure was elucidated as 2,6-bis(2,6-dichloro-4-hydroxyphenyloxy)-1,4-dimethoxy-benzene on the basis of spectroscopic data and confirmed by total synthesis.
authors.affiliation: Faculty of Pharmaceutical Sciences, Tohoku University, Sendai, Japan.
authors.forename: A
authors.initials: A
authors.lastname: Takahashi
authors.forename: T
authors.initials: T
authors.lastname: Agatsuma
authors.forename: M
authors.initials: M
authors.lastname: Matsuda
authors.forename: T
authors.initials: T
authors.lastname: Ohta
authors.forename: T
authors.initials: T
authors.lastname: Nunozawa
authors.forename: T
authors.initials: T
authors.lastname: Endo
authors.forename: S
authors.initials: S
authors.lastname: Nozoe
mesh_terms: D000818:Animals; D000840:Anisoles / Q000302:isolation & purification* / Q000633:toxicity; D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000302:isolation & purification* / Q000633:toxicity; D001487:Basidiomycota / Q000737:chemistry*; D002460:Cell Line; D002470:Cell Survival / Q000187:drug effects; D002733:Chlorophenols / Q000302:isolation & purification* / Q000633:toxicity; D003603:Cytotoxins / Q000138:chemical synthesis / Q000302:isolation & purification* / Q000633:toxicity; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D014407:Tumor Cells, Cultured
chemical_list: D000840:Anisoles; D000970:Antineoplastic Agents; D002733:Chlorophenols; D003603:Cytotoxins; C080188:russuphelin A