title: [Experimental approaches to treatment of prostatic adenoma with the luliberin analog surfagon].
abstract: Therapeutic efficacy of surfagon, an analog of LH-RH which was injected subcutaneously at a daily dose of 100 micrograms/kg for 30 days, was investigated in ACI male rats with induced prostatic adenoma. This drug was shown to be effective proceeding from a morphological study and measurement of the prostate. Measurement of blood testosterone levels by radioimmunoassay showed a decrease in this level in rats, treated with surfagon, i. e. a therapeutic effect of the drug in prostatic adenoma was accompanied by a decrease in the level of androgens.
authors.forename: I O
authors.initials: IO
authors.lastname: Smirnova
authors.forename: I M
authors.initials: IM
authors.lastname: Balueva
authors.forename: V I
authors.initials: VI
authors.lastname: Kiselev
authors.forename: O M
authors.initials: OM
authors.lastname: Pavlova
authors.forename: M I
authors.initials: MI
authors.lastname: Titov
authors.forename: I S
authors.initials: IS
authors.lastname: Burenin
mesh_terms: D000818:Animals; D007987:Gonadotropin-Releasing Hormone / Q000031:analogs & derivatives* / Q000627:therapeutic use; D006728:Hormones / Q000627:therapeutic use*; D008297:Male; D011470:Prostatic Hyperplasia / Q000097:blood / Q000188:drug therapy* / Q000473:pathology; D051381:Rats; D011912:Rats, Inbred ACI; D013739:Testosterone / Q000097:blood
chemical_list: D006728:Hormones; D007987:Gonadotropin-Releasing Hormone; D013739:Testosterone; C010661:surfagon
vernacular_title: Eksperimental'nye podkhody k lecheniiu adenomy predstatel'noĭ zhelezy analogom liuliberina surfagonom.