Primary oat cell (neuroendocrine) carcinoma of the breast. Report of four cases.
Four cases of oat cell (neuroendocrine) carcinoma of the breast are reported. Three patients died within 15 months of the diagnosis and the fourth patient is alive after 44 months. Histochemical, ultrastructural and mRNA markers of endocrine differentiation were present in three cases. These tumours show histological similarities to breast metastases of bronchial oat cell carcinoma, but a distinguishing feature is the presence of in situ ductal lesions. It appears that the breast is a further site which has to be added to the long list of extrapulmonary oat cell carcinomas.
Papotti
M
M
Dipartimento di Scienze Biomediche e Oncologia Umana, Università di Torino, Italy.
Gherardi
G
G
Eusebi
V
V
Pagani
A
A
Bussolati
G
G
D000328:Adult; D000368:Aged; D001943:Breast Neoplasms / Q000473:pathology* / Q000648:ultrastructure; D018288:Carcinoma, Small Cell / Q000473:pathology* / Q000648:ultrastructure; D002864:Chromogranins / Q000032:analysis / Q000235:genetics; D005260:Female; D006801:Humans; D008875:Middle Aged; D012333:RNA, Messenger / Q000032:analysis
D002864:Chromogranins; D012333:RNA, Messenger