[Mechanism of shen qian gujing granule in the treatment of menorrhagia].
Shen Qian Gujing Granule, a Chinese herbal preparation has shown its efficacy of 87.7% in treating menorrhagia. PGE2, PGE2 alpha, TXB2 and 6-Keto-PGF1 alpha levels were measured in the endometrium and menstrual blood of both normal menstrual women and patient with menorrhagia before and after the treatment. Local TXB2 values of endometrial and menstrual blood were significantly higher in menorrhagia patients than that in normal subjects (P < 0.05). And the local PGE2 values were higher in patients accompanied with Qi Deficiency (P < 0.05) and lower in patients without Qi Deficiency (P < 0.05). After the treatment, the local TXB2, PGE2 levels normalized. It suggests that Shen Qian Gujing Granule had a biphasic regulation on local PG values which yields good results for menorrhagia. Some mechanism were discussed.
Xia
H Q
HQ
Obstetrics and Gynecology Hospital, Shanghai Medical University.
Li
C J
CJ
Yu
J
J
D000328:Adult; D015232:Dinoprostone / Q000378:metabolism; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use*; D004717:Endometrium / Q000378:metabolism; D005260:Female; D006801:Humans; D008595:Menorrhagia / Q000188:drug therapy* / Q000378:metabolism; D013929:Thromboxane B2 / Q000378:metabolism
D004365:Drugs, Chinese Herbal; D013929:Thromboxane B2; D015232:Dinoprostone