Biochemical and molecular genetic aspects of eukaryotic pyruvate dehydrogenase multienzyme complexes.
The alpha-keto acid dehydrogenase multienzyme complexes play central roles in metabolism, are major sites of regulation, and are clinically important. Genes and cDNAs encoding the components of these complexes have been cloned and sequenced. Protein engineering and molecular cloning experiments are providing new insight into organization, structure-function relationships, and the molecular basis of genetic defects in these multienzyme complexes.
Reed
L J
LJ
Clayton Foundation Biochemical Institute, University of Texas, Austin 78712.
Lawson
J E
JE
Niu
X D
XD
Yazdi
M A
MA
Fussey
S P
SP
D000217:Acyltransferases / Q000737:chemistry / Q000502:physiology; D000595:Amino Acid Sequence; D000818:Animals; D005057:Eukaryotic Cells / Q000201:enzymology*; D008969:Molecular Sequence Data; D011506:Proteins / Q000737:chemistry / Q000502:physiology; D011768:Pyruvate Dehydrogenase Complex / Q000737:chemistry / Q000235:genetics* / Q000378:metabolism; D013329:Structure-Activity Relationship
D011506:Proteins; D011768:Pyruvate Dehydrogenase Complex; D000217:Acyltransferases