Platelet paroxetine binding in alcoholics.
Platelet paroxetine binding was analysed in 24 abstinent alcoholics and 18 control persons. The alcoholics had significantly more binding sites than the control persons. Most of the alcoholics showed affective symptoms and the increased platelet paroxetine binding was predominantly observed among those who had the lowest Newcastle score, indicating the presence of non-endogenous depression.
Mellerup
E T
ET
Institute of Neuropsychiatry, Rigshospitalet-6102, Copenhagen, Denmark.
Bech
P
P
Lauritzen
L
L
Lunde
M
M
Plenge
P
P
D000328:Adult; D000368:Aged; D000437:Alcoholism / Q000097:blood* / Q000523:psychology*; D001008:Anxiety Disorders / Q000097:blood*; D001665:Binding Sites; D001792:Blood Platelets / Q000502:physiology*; D003866:Depressive Disorder / Q000097:blood*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D017374:Paroxetine / Q000493:pharmacokinetics*; D011985:Receptors, Serotonin / Q000187:drug effects
D011985:Receptors, Serotonin; D017374:Paroxetine