[In vivo and in vitro antitumoral effects of an extract from Vibrio cholerae in different murine models. I. Effect in vivo of bacterial extract from Vibrio cholerae on the development of different murine tumoral grafts].
A bacterial extract from Vibrio cholerae, so called DGZ, is shown to prevent transplantation of sarcoma 180 and Lewis lung carcinoma. A 4 days DGZ treatment (4 x 100 micrograms) triggers reject of the graft by 40% of the mice. The mice which have rejected a graft once after treatment, cannot be grafted lately or, at least, the tumor growth is delayed. The association with cisplatinum (4 x 25 micrograms) allows to protect 90 to 95% of the mice.
Dodin
A
A
Unité Choléra et Vibrions, Institut Pasteur, Paris.
Zylberberg
B
B
Delorme
L
L
D000818:Animals; D000970:Antineoplastic Agents / Q000302:isolation & purification / Q000627:therapeutic use*; D066298:In Vitro Techniques; D051379:Mice; D008807:Mice, Inbred BALB C; D008810:Mice, Inbred C57BL; D009368:Neoplasm Transplantation; D009374:Neoplasms, Experimental / Q000188:drug therapy*; D012510:Sarcoma 180 / Q000188:drug therapy*; D014734:Vibrio cholerae / Q000737:chemistry*
D000970:Antineoplastic Agents
Effets antitumoraux in vivo et in vitro d'un extrait de Vibrio cholerae dans différents modèles murins. I. Effet in vivo d'un extrait bactérien de Vibrio cholerae sur l'évolution de différentes greffes tumorales murines.