Prevention of cytomegalovirus infection after organ transplantation with passive immunization. An analysis of 6 randomized clinical trials.
We performed a meta-analysis of 6 randomized clinical trials to study the efficacy of passive immunization against CMV in solid organ transplantation. The results indicate that passive immunization against CMV prevents (fatal) CMV disease in CMV seronegative recipients of a CMV seropositive allograft, even when treated with additional immunosuppression in case of rejections. Passive immunization with anti-CMV immunoglobulin preparations did not reduce the incidence of CMV infection or disease in CMV seropositive recipients.
Metselaar
H
H
Department of Internal Medicine, University Hospital Rotterdam-Dijkzigt, The Netherlands.
Weimar
W
W
D003586:Cytomegalovirus Infections / Q000276:immunology / Q000517:prevention & control*; D006801:Humans; D007108:Immune Tolerance / Q000276:immunology; D007116:Immunization, Passive; D009894:Opportunistic Infections / Q000276:immunology / Q000517:prevention & control*; D014181:Transplantation Immunology / Q000276:immunology*