title: [The main principles in the combined action of metals and their significance for hygiene].
abstract: Features of metal's co-action according to the results of toxico inetic studies concerning the binary elemental combinations infused into the body are discussed. The investigations revealed that the stoichiometric laws of metals' co-action depended on the way the metals were infused by and the scheme of their combined action, on their qualitative and quantitative composition. The quantitative changes in the metabolism of metals during their co-action were found the most important. These changes may serve to evaluate and forecast the combined action of metals. The role of individual metallic qualities in their metabolic co-action was proved to be important.
authors.forename: M A
authors.initials: MA
authors.lastname: Kazimirov
authors.forename: A V
authors.initials: AV
authors.lastname: Roshchin
mesh_terms: D000042:Absorption; D000818:Animals; D004064:Digestive System / Q000187:drug effects / Q000378:metabolism; D004347:Drug Interactions; D004781:Environmental Exposure; D015386:Hazardous Substances / Q000097:blood / Q000493:pharmacokinetics / Q000633:toxicity*; D006801:Humans; D007668:Kidney / Q000187:drug effects / Q000378:metabolism; D008099:Liver / Q000187:drug effects / Q000378:metabolism; D008657:Metabolic Clearance Rate; D008670:Metals / Q000097:blood / Q000493:pharmacokinetics / Q000633:toxicity*; D016273:Occupational Exposure; D051381:Rats
chemical_list: D015386:Hazardous Substances; D008670:Metals
vernacular_title: Osnovnye zakonomernosti kombinirovannogo deĭstviia metallov i ikh znachenie v gigiene.