title: Effects of plant extract Centella asiatica (Linn.) on cold restraint stress ulcer in rats.
abstract: Extract of C. asiatica (Linn.) inhibited significantly gastric ulceration induced by cold and restraint stress (CRS) in Charles-Foster rats, Antiulcer activity of plant extract was compared with famotidine (H2-antagonist) and sodium valproate (anti-epileptic). Plant extract, formotidine and sodium valproate showed a dose dependent reduction of gastric ulceration. Plant extract increased brain GABA level which was also dose dependent. Pretreatment with bicuculline methiodide (specific GABAA-antagonist) at the dose level of 0.5 mg/kg im, reversed the antiulcerogenic activity of both plant extract and sodium valproate. Bicuculline as such did not induce gastric ulceration in normal rat.
authors.affiliation: Department of Pharmaceutical Technology, Jadavpur University, Calcutta, India.
authors.forename: T K
authors.initials: TK
authors.lastname: Chatterjee
authors.forename: A
authors.initials: A
authors.lastname: Chakraborty
authors.forename: M
authors.initials: M
authors.lastname: Pathak
authors.forename: G C
authors.initials: GC
authors.lastname: Sengupta
mesh_terms: D000818:Animals; D001921:Brain / Q000378:metabolism; D004305:Dose-Response Relationship, Drug; D005260:Female; D008297:Male; D010936:Plant Extracts / Q000627:therapeutic use; D010946:Plants, Medicinal; D051381:Rats; D011919:Rats, Inbred Strains; D013276:Stomach Ulcer / Q000517:prevention & control*; D013312:Stress, Physiological; D005680:gamma-Aminobutyric Acid / Q000096:biosynthesis
chemical_list: D010936:Plant Extracts; D005680:gamma-Aminobutyric Acid