Management of antiphospholipid antibody positivity and elective orthopedic procedures.
Current management of primary or secondary antiphospholipid antibody (aPL) syndromes with known embolic phenomena requiring anticoagulation is empiric in the setting of elective orthopedic procedures. Short-term withdrawal of warfarin with continuance of aspirin and glucocorticoid therapy was undertaken for sequential bilateral knee replacements in a lupus patient with aPL. Her course was successfully managed without thrombo-embolic complications.
Schnitz
W M
WM
Division of Rheumatology and Immunology, Oklahoma Memorial Hospital, Oklahoma City.
Lister
K A
KA
McCarty
G A
GA
D000328:Adult; D017152:Antibodies, Antiphospholipid / Q000097:blood*; D000925:Anticoagulants / Q000627:therapeutic use; D016736:Antiphospholipid Syndrome / Q000150:complications / Q000188:drug therapy / Q000276:immunology; D005260:Female; D006801:Humans; D007720:Knee Prosthesis / Q000009:adverse effects; D008180:Lupus Erythematosus, Systemic / Q000150:complications / Q000276:immunology* / Q000601:surgery*; D010020:Osteonecrosis / Q000150:complications / Q000276:immunology / Q000601:surgery; D011183:Postoperative Complications / Q000517:prevention & control; D013923:Thromboembolism / Q000517:prevention & control
D017152:Antibodies, Antiphospholipid; D000925:Anticoagulants