Acute renal failure occurring during intravenous desferrioxamine therapy: recovery after haemodialysis.
A patient with transfusion-dependent thalassemia was undergoing home intravenous desferrioxamine (DFX) treatment by means of a totally implanted system because of his poor compliance with the nightly subcutaneous therapy. Due to an accidental malfunctioning of the infusion pump, the patient was inadvertently administered a toxic dosage of the drug which caused renal insufficiency. Given the progressive deterioration of the symptoms and of the laboratory values, despite adequate medical treatment, a decision was made to introduce haemodialytical therapy in order to remove the drug and therapy reduce the nephrotoxicity. From the results obtained, haemodialysis can therefore be suggested as a useful therapy in rare cases of progressive acute renal failure caused by desferrioxamine.
Cianciulli
P
P
Cattedra di Ematologia, Ospedale S. Eugenio, Roma, Italy.
Sorrentino
F
F
Forte
L
L
Palombi
M
M
Papa
G
G
Meloni
C
C
Taccone Gallucci
M
M
Casciani
C U
CU
D058186:Acute Kidney Injury / Q000139:chemically induced* / Q000628:therapy; D000328:Adult; D015913:Chelation Therapy / Q000009:adverse effects*; D003676:Deferoxamine / Q000008:administration & dosage / Q000009:adverse effects*; D062787:Drug Overdose; D004868:Equipment Failure; D006699:Home Care Services; D006801:Humans; D015918:Infusion Pumps, Implantable; D007262:Infusions, Intravenous / Q000295:instrumentation; D008297:Male; D006435:Renal Dialysis; D017086:beta-Thalassemia / Q000150:complications* / Q000188:drug therapy
D003676:Deferoxamine