title: [Contribution of intra-operative measurement of intact parathormone in surgery for primary hyperparathyroidism].
abstract: Using a sensitive two-site immunoradiometric assay which detects intact parathormone (iPTH), we studied the decrease in peripheric and jugular plasmatic iPTH during surgical removal of abnormal parathyroid (s). In the next future, results of intact parathormone (iPTH) assay will be given in 45 minutes. In a prospective study of 33 patients operated on for hyperparathyroidism or for cold thyroid nodule, the serum levels of intact PTH was measured intraoperatively in peripheric and in jugular blood. The preoperative mean serum iPTH concentration was 119.23 +/- 172.48 pg/ml and fell to 34.5 +/- 32.21 pg/ml after surgery in 14 cases of primary hyperparathyroidism (p < 0.001). Thirteen out of 14 patients had serum iPTH values less than 65 pg/ml within 15 minutes after parathyroidectomy. The preoperative mean serum iPTH concentration in the 5 secondary hyperparathyroidism was 781.2 +/- 403.19 pg/ml. This value fell to 124 +/- 66.91 pg/ml after parathyroidectomy (p < 0.04). No significant decrease was observed in the mean serum concentration of the 14 patients operated on for cold thyroid nodule. Patients suffering from single parathyroid adenoma presented a significant gradient in jugular plasmatic PTH concentration between the adenoma side and the contralateral one. This gradient decreased during effective parathyroid adenomectomy (309.7 +/- 313.3 pg/ml to 3.7 +/- 35.1 pg/ml). Intraoperative serum iPTH concentration will provide a valuable tool to appreciate the effectiveness of surgical removal of parathyroid glands and to detect the location of parathyroid adenoma when the surgical research is negative.
authors.affiliation: Clinique Médicale et Endocrinologique, CHU de Nancy, Hôpitaux de Brabois, Vandoeuvre les Nancy.
authors.forename: M
authors.initials: M
authors.lastname: Duquenne
authors.forename: O
authors.initials: O
authors.lastname: Roche
authors.forename: N
authors.initials: N
authors.lastname: De Talance
authors.forename: T
authors.initials: T
authors.lastname: Duriez
authors.forename: N
authors.initials: N
authors.lastname: Bischoff
authors.forename: J
authors.initials: J
authors.lastname: Avila
authors.forename: G
authors.initials: G
authors.lastname: Weryha
authors.forename: P
authors.initials: P
authors.lastname: Mathieu
authors.forename: J
authors.initials: J
authors.lastname: Leclère
mesh_terms: D000328:Adult; D000368:Aged; D005260:Female; D006207:Half-Life; D006801:Humans; D006961:Hyperparathyroidism / Q000097:blood / Q000453:epidemiology / Q000601:surgery*; D006962:Hyperparathyroidism, Secondary / Q000453:epidemiology / Q000601:surgery; D007432:Intraoperative Period; D008297:Male; D008875:Middle Aged; D010281:Parathyroid Hormone / Q000097:blood* / Q000493:pharmacokinetics; D011446:Prospective Studies
chemical_list: D010281:Parathyroid Hormone
vernacular_title: Apport du dosage per-opératoire de la parathormone intacte dans la chirurgie de l'hyperparathyroidie primaire.