title: A study of bronchial reactivity in relation to baseline pulmonary functions in patients with chronic obstructive lung disease.
abstract: Baseline bronchial reactivity was studied in 36 patients with chronic obstructive lung disease (COLD) and 20 normal healthy controls using the inhalational histamine challenge test. Using a cut off PD20 dose of 0.195 mg of histamine, 83.3% patients of COLD demonstrated bronchial hyper-reactivity. Presence of bronchial reactivity correlated significantly with the baseline FEV1, FEF25-75 and the ratio FEV1/FVC (p = 0.0019, 0.00001 and 0.008) respectively. Thus, bronchial reactivity in subjects with COLD correlates most significantly with the maximum mid-expiratory flow rate (FEF25-75).
authors.affiliation: Department of Respiratory Medicine, Safdarjang Hospital, New Delhi.
authors.forename: J C
authors.initials: JC
authors.lastname: Suri
authors.forename: A
authors.initials: A
authors.lastname: Dar
authors.forename: A
authors.initials: A
authors.lastname: Goel
mesh_terms: D016535:Bronchial Hyperreactivity / Q000503:physiopathology*; D001985:Bronchial Provocation Tests; D006632:Histamine; D006801:Humans; D008173:Lung Diseases, Obstructive / Q000175:diagnosis / Q000503:physiopathology*; D008297:Male; D008875:Middle Aged; D012129:Respiratory Function Tests; D012907:Smoking / Q000503:physiopathology*
chemical_list: D006632:Histamine