title: Interaction between Ukrain and aminophenazone in analgesic tests in rodents.
abstract: The effect of Ukrain on the analgesic activity of aminophenazone was studied in mice and rats. Antinociceptive action induced by aminophenazone in doses of 50 or 100 mg/kg intraperitoneally (i.p.) was determined by using the writhing syndrome, hot-plate tests and tail-flick latency. The action of aminophenazone was significantly enhanced by Ukrain in the writhing syndrome test and in the tail-flick test. Antinociceptive action of aminophenazone was decreased by Ukrain in the hot-plate test in mice. These results suggest that Ukrain, given simultaneously with aminophenazone, changes susceptibility of animals to nociceptive reaction in the tests performed.
authors.affiliation: Department of Pharmacology, Medical Academy, Lublin, Poland.
authors.forename: Z
authors.initials: Z
authors.lastname: Kleinrok
authors.forename: E
authors.initials: E
authors.lastname: Jagiełło-Wójtowicz
authors.forename: J W
authors.initials: JW
authors.lastname: Nowicky
authors.forename: A
authors.initials: A
authors.lastname: Chodkowska
authors.forename: M
authors.initials: M
authors.lastname: Feldo
mesh_terms: D000085:Acetates; D019342:Acetic Acid; D000470:Alkaloids / Q000008:administration & dosage / Q000494:pharmacology*; D000632:Aminopyrine / Q000008:administration & dosage / Q000494:pharmacology*; D000700:Analgesics / Q000008:administration & dosage / Q000494:pharmacology*; D000818:Animals; D001600:Berberine Alkaloids; D004357:Drug Synergism; D007274:Injections, Intraperitoneal; D008297:Male; D051379:Mice; D010146:Pain / Q000139:chemically induced; D010147:Pain Measurement / Q000187:drug effects; D010617:Phenanthridines; D051381:Rats; D017208:Rats, Wistar; D011930:Reaction Time / Q000187:drug effects
chemical_list: D000085:Acetates; D000470:Alkaloids; D000700:Analgesics; D001600:Berberine Alkaloids; D010617:Phenanthridines; D000632:Aminopyrine; C060921:ukrain; D019342:Acetic Acid