Synthesis and interaction studies of watersoluble nucleic acid analogs containing serine as a spacer.
Watersoluble nucleic acid analogs containing L- or D-serine as a spacer were synthesized. Thymine was used as nucleic acid bases of these analogs. The base contents of these analogs were 93-94%. These analogs were found to form stable polymer complexes with Poly A or DNA by specific base-base interaction, which were observed from hypochromicity of UV spectra. In both cases, the maximum hypochromicity values of PEI-L-Ser-Thy were higher than that of PEI-D-Ser-Thy.
Wada
T
T
Faculty of Engineering, Osaka University, Japan.
Masumi
N
N
Mochizuki
E
E
Inaki
Y
Y
Takemoto
K
K
D002942:Circular Dichroism; D004247:DNA / Q000737:chemistry; D015394:Molecular Structure; D009696:Nucleic Acids / Q000138:chemical synthesis*; D011061:Poly A / Q000737:chemistry; D012694:Serine / Q000737:chemistry*; D012995:Solubility; D014867:Water
D009696:Nucleic Acids; D014867:Water; D011061:Poly A; D012694:Serine; D004247:DNA