[Immune complex in the wall of the gallbladder in patients with cholelithiasis: deposition and its pathological significance].
The gallbladder specimens from 53 patients with cholelithiasis were studied by immunohistochemical method. Deposition of immune complex (IC) was observed on the mucosal and glandular epithelium in 84% of patients with gallstones and 47% of patients with choledocholithiasis. IgG and C3 were the most frequent complement component demonstrated at the site of IC deposition, but Clq, factor B and C4 were also present in many cases, suggesting the local complement activation. We conclude that IC may play a pathogenetic role in the injury of the mucosa and tissue of gallbladder in patients with cholelithiasis.
Yang
Y
Y
Nanfang Hospital, Guangzhou.
D000936:Antigen-Antibody Complex / Q000032:analysis*; D001649:Bile Duct Diseases / Q000276:immunology / Q000473:pathology; D002764:Cholecystitis / Q000276:immunology; D002769:Cholelithiasis / Q000276:immunology* / Q000473:pathology; D003167:Complement Activation; D003176:Complement C3 / Q000378:metabolism; D005704:Gallbladder / Q000276:immunology*; D006801:Humans
D000936:Antigen-Antibody Complex; D003176:Complement C3