title: [The cytoarchitectonics of the adenohypophysis in light of the concepts of cellular flows].
abstract: Analysis of published data allows to suggest a possible model of adenohypophyseal cytoarchitectonics based on the concepts of tissue self-renewal and streaming in this gland. The model provides a framework for understanding: a) the existence of ambiguous cellular elements; b) change of relationship between different types of hormone secreting cells with sex-dependent prevalence of somato- or lactotrophs; c) relatively high proliferative activity of lactotrophs in mature pituitary gland; d) specific spatial arrangement of various types of hormone secreting cells; e) multiple effects of some bioregulators on the secretion of two or more pituitary hormones; f) the existence of polyfunctional pituitary adenomata containing and secreting several adenohypophyseal hormones simultaneously. Possible approaches to thorough evaluation and testing of the model in experiments using organ or cell cultures of adenohypophysis are discussed.
authors.forename: V I
authors.initials: VI
authors.lastname: Gudoshnikov
mesh_terms: D000818:Animals; D002454:Cell Differentiation; D006801:Humans; D008938:Mitosis; D008954:Models, Biological; D010903:Pituitary Gland, Anterior / Q000166:cytology* / Q000378:metabolism; D010908:Pituitary Hormones, Anterior / Q000378:metabolism
chemical_list: D010908:Pituitary Hormones, Anterior
vernacular_title: Tsitoarkhitektonika adenogipofiza v svete predstavleniĭ o kletochnykh potokakh.