The influence of maternal nicotine exposure on neonatal lung carbohydrate metabolism.
The influence of maternal nicotine exposure (1 mg/kg body mass/day) during pregnancy and lactation on energy metabolism of lung tissue of neonatal rats were investigated. The glucose turnover of the lung tissue of the neonatal rats exposed to nicotine via the placenta and mother's milk was 86.4% higher than that of the controls. Glycolysis was however suppressed by 22.7% (P < 0.01). The adenine nucleotide pool (ATP+ADP+AMP) was 32.8% higher for the lungs of the 3 week old neonates exposed to nicotine than that of the control rat lung. After 4 weeks of nicotine withdrawal glycolysis of those animals exposed to nicotine were still inhibited to the same extent than during exposure. The adenine nucleotide pool was 69.95% higher than that of the controls. It is proposed that the inhibition of glycolysis was due to the high ATP/ADP ratio of the lungs of the nicotine exposed rats.
Maritz
G S
GS
Dept. Physiological Sciences, University of the Western Cape, South Africa.
Burger
B
B
D000244:Adenosine Diphosphate / Q000032:analysis; D000249:Adenosine Monophosphate / Q000032:analysis; D000255:Adenosine Triphosphate / Q000032:analysis; D000818:Animals; D000831:Animals, Newborn / Q000378:metabolism; D004734:Energy Metabolism / Q000187:drug effects; D005260:Female; D005947:Glucose / Q000378:metabolism; D006019:Glycolysis / Q000187:drug effects*; D007774:Lactation; D008168:Lung / Q000187:drug effects* / Q000378:metabolism; D009538:Nicotine / Q000633:toxicity*; D010732:Phosphofructokinase-1 / Q000187:drug effects*; D011247:Pregnancy; D051381:Rats
D000249:Adenosine Monophosphate; D000244:Adenosine Diphosphate; D009538:Nicotine; D000255:Adenosine Triphosphate; D010732:Phosphofructokinase-1; D005947:Glucose