[Studies on IFN-gamma production by peripheral blood mononuclear cells cultured with Candida antigen in asthmatics].
T-cell-derived lymphokine, IFN-gamma, has potent effects on B-cell differentiation and leukotriene C4 production in leukocytes, and inhibits the effect of IL-4 on IgE production. To investigate the role of IFN-gamma in the pathogenesis of bronchial asthma, we examined IFN-gamma production by peripheral blood mononuclear cells cultured with Candida antigen and serum Candida specific IgG1 antibody from 20 asthmatics. The results were as follows: 1) IFN-gamma production in non-atopic severe asthmatics was significantly higher than in healthy subjects, atopic mild and moderate asthmatics, and atopic severe asthmatics (p < 0.05). 2) There was a significant correlation between IFN-gamma production induced by Candida antigen and serum Candida specific IgG1 antibody (r = 0.72, p < 0.01). These results suggest that IFN-gamma may play an important role in the pathogenesis of non-atopic severe bronchial asthma.
Kimura
G
G
Second Department of Medicine, Okayama University Medical School.
Ogurusu
K
K
Soda
R
R
Tada
S
S
Takahashi
K
K
Kimura
I
I
D000328:Adult; D000368:Aged; D000946:Antigens, Fungal / Q000276:immunology*; D001249:Asthma / Q000276:immunology*; D002175:Candida / Q000276:immunology*; D005260:Female; D006801:Humans; D066298:In Vitro Techniques; D007371:Interferon-gamma / Q000096:biosynthesis* / Q000097:blood; D007963:Leukocytes, Mononuclear / Q000378:metabolism*; D008297:Male; D008875:Middle Aged
D000946:Antigens, Fungal; D007371:Interferon-gamma