title: [Genetic aspects of renal tumors in adults].
abstract: The aetiopathogenesis of adult renal tumors is poorly understood. The specific chromosomal changes detected by the study of tumor karyotypes suggest a cascade of oncogene activation and tumor suppressor gene inactivation in the course of renal carcinogenesis. These cytogenetic studies have isolated two entities: non-papillary carcinomas (clear cell and/or eosinophil carcinomas) and tubulopapillary tumors (cortical adenoma, basophil papillary carcinoma). Specific changes of the short arm of chromosome 3 are observed in 70 to 85% of cases of clear cell carcinomas, while trisomy 17 is detected in 70% of cases of tubulopapillary tumors. Cytogenetics is also able to distinguish low and high grade malignant tubulopapillary carcinomas. Limited data are available at the present time concerning oncocytomas.
authors.affiliation: INSERM Unité 73, Paris.
authors.forename: J C
authors.initials: JC
authors.lastname: Fournet
authors.forename: C
authors.initials: C
authors.lastname: Béroud
authors.forename: E
authors.initials: E
authors.lastname: Austruy
authors.forename: C
authors.initials: C
authors.lastname: Léonard
mesh_terms: D000236:Adenoma / Q000235:genetics*; D000328:Adult; D002277:Carcinoma / Q000235:genetics*; D002869:Chromosome Aberrations / Q000235:genetics; D025063:Chromosome Disorders; D002883:Chromosomes, Human, Pair 14; D002886:Chromosomes, Human, Pair 17; D002893:Chromosomes, Human, Pair 3; D002895:Chromosomes, Human, Pair 5; D002897:Chromosomes, Human, Pair 7; D016147:Genes, Tumor Suppressor / Q000235:genetics*; D006801:Humans; D007680:Kidney Neoplasms / Q000235:genetics*; D009857:Oncogenes / Q000235:genetics*; D014314:Trisomy
vernacular_title: Aspects génétiques des tumeurs rénales de l'adulte.