title: Results of the National Kidney Transplantation Program in Norway.
abstract: 1. Of 2,003 patients starting renal replacement therapy for end-stage renal disease in Norway from 1983 through 1991, 83% were candidates for transplantation. The need for transplantations increased to 58 (50 first and 8 repeat) grafts PMP per year as the number of elderly patients increased. 2. There were 1,528 transplants performed at a rate increasing to 46 grafts PMP per year. The grafts were procured from LDs in 44% and CDs in 56%. Eighty percent of all patients in need were transplanted and 65% of all patients requiring replacement therapy for end-stage renal disease were treated by transplantation. The national waiting list and dialysis population remained almost stable. 3. Graft survival rates in recipients of first LD grafts (n = 593) were 91% and 77% at 1 and 5 years, respectively. One-year graft survival was 98% in HLA-identical grafts (n = 73), 91% in haploidentical grafts (n = 411), 89% in 2 haplotype-mismatched related grafts (n = 38), and 85% in spousal donor grafts (n = 71). Higher rates were observed in younger (< 55 yrs) patients. 4. Graft survival rates in recipients of first CD grafts (n = 688) were 78% and 59% at 1 and 5 years, respectively. The rates were 84% and 66% in younger (n = 342) versus 72% and 52% in older (> 55 years) (n = 346) patients. Death with a functioning graft caused approximately 45% and 75% of all graft losses in younger and older patients, respectively. Cardiovascular disease was the major cause of death.(ABSTRACT TRUNCATED AT 250 WORDS)
authors.affiliation: National Hospital, University of Oslo, Norway.
authors.forename: D
authors.initials: D
authors.lastname: Albrechtsen
authors.forename: T
authors.initials: T
authors.lastname: Leivestad
authors.forename: P
authors.initials: P
authors.lastname: Fauchald
authors.forename: A
authors.initials: A
authors.lastname: Flatmark
authors.forename: G
authors.initials: G
authors.lastname: Sødal
authors.forename: E
authors.initials: E
authors.lastname: Thorsby
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002102:Cadaver; D002648:Child; D002675:Child, Preschool; D006085:Graft Survival; D006801:Humans; D007223:Infant; D007676:Kidney Failure, Chronic / Q000601:surgery; D016030:Kidney Transplantation / Q000379:methods / Q000401:mortality / Q000706:statistics & numerical data*; D008875:Middle Aged; D009664:Norway / Q000453:epidemiology; D012086:Reoperation; D015996:Survival Rate; D014019:Tissue Donors; D014850:Waiting Lists