Repandiol, a new cytotoxic diepoxide from the mushrooms Hydnum repandum and H. repandum var. album.
Repandiol, a new cytotoxic diepoxide has been isolated from the mushrooms Hydnum repandum and H. repandum var. album. The chemical structure was elucidated as (2R,3R,8R,9R)-4,6-decadiyne-2,3:8,9-diepoxy-1,10-diol on the basis of spectroscopic analysis. The structure was confirmed by the synthesis of optically active repandiol. Repandiol displayed potent cytotoxic activity against various tumor cells.
Takahashi
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Faculty of Pharmaceutical Sciences, Tohoku University, Sendai, Japan.
Endo
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Nozoe
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D000480:Alkynes / Q000138:chemical synthesis / Q000302:isolation & purification* / Q000633:toxicity; D000818:Animals; D000972:Antineoplastic Agents, Phytogenic; D001487:Basidiomycota / Q000737:chemistry*; D002460:Cell Line; D003603:Cytotoxins / Q000138:chemical synthesis / Q000302:isolation & purification* / Q000633:toxicity; D004354:Drug Screening Assays, Antitumor; D004852:Epoxy Compounds / Q000138:chemical synthesis / Q000302:isolation & purification* / Q000633:toxicity; D006801:Humans; D013237:Stereoisomerism; D014407:Tumor Cells, Cultured
D000480:Alkynes; D000972:Antineoplastic Agents, Phytogenic; D003603:Cytotoxins; D004852:Epoxy Compounds; C080187:repandiol