Interleukin 10: an overview.
Since the original description of interleukin-10, a wealth of information concerning its biological properties has been gathered. Studies in vitro have rapidly identified both immunostimulatory and immunosuppressive activities for IL-10. Based on these findings, in vivo studies were initiated in a variety of animal disease models to assess the importance of these activities. This review will summarize the pleiotropic properties of IL-10 and will survey current research regarding the potential of IL-10 to regulate acute and chronic inflammatory reactions.
Rennick
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Department of Immunology, DNAX Research Institute, Palo Alto, California 95603.
Berg
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Holland
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D000818:Animals; D006410:Hematopoiesis / Q000502:physiology; D006412:Hematopoietic Stem Cells / Q000502:physiology; D006801:Humans; D016753:Interleukin-10 / Q000737:chemistry / Q000502:physiology*; D006377:T-Lymphocytes, Helper-Inducer / Q000276:immunology
D016753:Interleukin-10