title: Pericapillary collagen in the human thymus: implications for the concept of the 'blood-thymus' barrier.
abstract: The deposition of collagen in the walls of capillary-size blood vessels was studied in 95 human thymuses with respect to the site of deposition, extent of the change and relation to age and degree of involution. When examined by electron microscopy the collagen was found to be situated between the 2 basement membranes of the so-called 'double-layered' capillaries characteristic of the thymus of many species. This results in the formation of substantial 'collars' of collagen around a proportion of the blood vessels examined. Few such collars are seen before birth, but their number and thickness increase markedly during the 1st year of life. The relationship of these changes to the degree of involution is less apparent. The significance of these changes to thymic structure and function is discussed in relation to cell traffic through the thymus and the postulated 'blood-thymus barrier', the existence of which is seen to be in some doubt.
authors.affiliation: Department of Pathology, University of Sheffield Medical School, UK.
authors.forename: L
authors.initials: L
authors.lastname: Henry
authors.forename: T E
authors.initials: TE
authors.lastname: Durrant
authors.forename: G
authors.initials: G
authors.lastname: Anderson
mesh_terms: D000375:Aging / Q000502:physiology; D002196:Capillaries / Q000648:ultrastructure; D003094:Collagen / Q000378:metabolism* / Q000648:ultrastructure; D005260:Female; D006801:Humans; D008297:Male; D008854:Microscopy, Electron; D013950:Thymus Gland / Q000098:blood supply* / Q000196:embryology / Q000254:growth & development / Q000648:ultrastructure
chemical_list: D003094:Collagen