[A morphological evaluation of the action of collagenase from the king crab Paralithodes camtschatica on the experimental wound process].
The paper presents the results of experimental morphological evaluation of the effect of a new proteolytic enzyme collagenase of crab Paralithodes camtschatica on wound healing in infected and aseptic rabbit wounds. The enzyme was applied on wounds using gauze and gelevin. The findings show that this protease is highly effective for debridement of infected wounds, the effect increasing at gelevin addition. To reach maximal therapeutical effect and diminish the inhibition effect of collagenase on granulation tissue, it is recommended to reduce the dose of protease during debridement process. Clinical application of crab collagenase must be individual as well as duration of wound enzymotherapy.
Adamian
A A
AA
Gliantsev
S P
SP
Sakharov
I Iu
IIu
Savvina
T V
TV
D000818:Animals; D000890:Anti-Infective Agents / Q000627:therapeutic use; D001458:Bandages; D003386:Brachyura / Q000201:enzymology*; D017364:Collagenases / Q000302:isolation & purification / Q000627:therapeutic use*; D004353:Drug Evaluation, Preclinical; D008297:Male; D009336:Necrosis; D011142:Polyvinyl Alcohol; D011817:Rabbits; D013203:Staphylococcal Infections / Q000188:drug therapy / Q000473:pathology; D013997:Time Factors; D014945:Wound Healing / Q000187:drug effects*; D014946:Wound Infection / Q000188:drug therapy / Q000473:pathology
D000890:Anti-Infective Agents; C079932:gelevin; D011142:Polyvinyl Alcohol; D017364:Collagenases
Morfologicheskaia otsenka vozdeĭstviia kollagenazy kamchatskogo kraba Paralithodes camtschatica na ranevoĭ protsess v éksperimente.