title: Measurement of nerve growth factor-like immunoreactivity in human brain using an anti-mouse-NGF enzyme immunoassay.
abstract: Nerve growth factor (NGF) like immunoreactivity, expressed as mouse 2.5S nerve growth factor equivalents, was evaluated in three structures of the human brain post-mortem using a commercially available enzyme immunoassay. Regional differences in NGF-like immunoreactivity were observed. Highest levels were found in hippocampus (148 pg/g) compared to putamen (76 pg/g) and frontal cortex (34 pg/g). In addition, these results suggest differences in the distribution of brain NGF between human and rodent, where relatively high levels of NGF are found in the cortex.
authors.affiliation: Rhône-Poulenc Rorer, Centre de Recherche de Vitry-Alfortville, Vitry Sur Seine, France.
authors.forename: P
authors.initials: P
authors.lastname: Bertrand
authors.forename: O
authors.initials: O
authors.lastname: Roger
authors.forename: R
authors.initials: R
authors.lastname: Houlgatte
authors.forename: F
authors.initials: F
authors.lastname: Javoy-Agid
authors.forename: J P
authors.initials: JP
authors.lastname: Brandel
authors.forename: A
authors.initials: A
authors.lastname: Doble
authors.forename: J C
authors.initials: JC
authors.lastname: Blanchard
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000818:Animals; D001923:Brain Chemistry; D005625:Frontal Lobe / Q000737:chemistry; D006624:Hippocampus / Q000737:chemistry; D006801:Humans; D007124:Immunoenzyme Techniques; D008297:Male; D009414:Nerve Growth Factors / Q000032:analysis*; D009928:Organ Specificity; D011699:Putamen / Q000737:chemistry; D051381:Rats; D017207:Rats, Sprague-Dawley; D012016:Reference Values; D013045:Species Specificity
chemical_list: D009414:Nerve Growth Factors