Analysis by digital simulation of the peripheral and renal resistance in hypovolemic hypotension.
A haemorrhage was simulated and analysis of dynamic behaviour of renal resistance, renal nervous activity and peripheral resistances were processed, with the aim of studying the paradoxical behaviour of renal resistance as opposed to peripheral resistances and the increase of sympathetic activity in hypovolemic shock situations using both non-linear models of the renal blood flow and arterial pressure and body fluids. The following conclusions can be made after comparing the results obtained by simulation with data related to animal experimentation models: the model is useful for its use in the analysis of nervous activity, resistance and renal flow in hypovolemic shock situations in humans and the control structure it puts forward can explain the paradoxical behaviour of renal vascular resistance as opposed to the peripheral resistances and the increase in the renal nervous activity in the aforementioned circumstances.
Roa
L
L
Grupo de Ingeniería Biomédica, Escuela Técnica Superior de Ingenieros, Industriales, Sevilla, Spain.
Garrachón
F
F
González-Barón
S
S
D001794:Blood Pressure; D003198:Computer Simulation; D006470:Hemorrhage / Q000150:complications; D007022:Hypotension / Q000209:etiology / Q000503:physiopathology*; D007668:Kidney / Q000294:innervation; D008955:Models, Cardiovascular; D012077:Renal Artery; D012079:Renal Circulation; D012769:Shock / Q000209:etiology / Q000503:physiopathology*; D013564:Sympathetic Nervous System / Q000503:physiopathology; D014655:Vascular Resistance