[The IgE system].
The IgE synthesis is regulated by a system of immunocompetent cells (B and T lymphocytes) and cytokines (IL-4, IFN gamma, IL-2, IL-5, IL-6) produced by T cells as a response to antigenic stimuli. IL-4 alone, or associated with other cytokines, determines the CD23+ receptor (FCERII) expression on monocytes-macrophages, eosinophiles, platelets, epidermidis Langerhans cells and B lymphocytes surfaces, inducing its cleavage in a Soluble Factor (IgE-BF), that increases the IgE synthesis. IFN-gamma, on the other hand, plays an inhibitory role on T-dependent phenomena, IL-4-mediated. In patients affected by atopic diseases, associated with oculorhinites, dermatitis and hyper-IgE syndrome, are found high serum levels of IgE, eosinophiles, and a large number of CD23+ cells: this indicates the hyper-reactivity of the IgE system and the IL-4 overproduction.
Di Monaco
C
C
Istituto di Clinica Medica III, Università La Sapienza, Roma.
Tanzilli
O
O
Guido
F
F
Cossu
M F
MF
Amoroso
A
A
D000818:Animals; D001402:B-Lymphocytes / Q000276:immunology / Q000378:metabolism; D016207:Cytokines / Q000502:physiology; D006801:Humans; D007073:Immunoglobulin E / Q000096:biosynthesis / Q000276:immunology / Q000502:physiology*; D017455:Receptors, IgE / Q000378:metabolism; D013601:T-Lymphocytes / Q000276:immunology / Q000378:metabolism
D016207:Cytokines; D017455:Receptors, IgE; D007073:Immunoglobulin E
Il sistema IgE.