Autoantibodies to leucocyte antigens in hydralazine-associated nephritis.
Clinical and laboratory findings and drug history were studied in 17 patients with suspected hydralazine-associated nephritis, five of whom only had renal disease, while twelve also had extrarenal manifestations. Renal biopsies revealed extracapillary proliferative or focal segmental proliferative glomerulonephritis in 10 patients, and tubulo-interstitial nephritis in five patients. Antinuclear antibody (ANA) was found in 16 patients, but none of the 14 patients tested had antibodies to DNA. Tests for antibodies to myeloperoxidase (anti-MPO) and antibodies to neutrophil cytoplasm antigen (ANCA) were performed by ELISA. Twelve of the 14 patients tested had anti-MPO; five of these 14 patients had ANCA, while one had borderline levels. These findings suggest that hydralazine facilitates the induction of a systemic disease with multiple autoantibody production.
Almroth
G
G
Department of Nephrology, University Hospital of Linköping, Sweden.
Eneström
S
S
Hed
J
J
Samuelsson
I
I
Sjöström
P
P
D000974:Antibodies, Antinuclear / Q000032:analysis*; D005260:Female; D005923:Glomerulosclerosis, Focal Segmental / Q000139:chemically induced / Q000276:immunology*; D006680:HLA Antigens / Q000276:immunology*; D006801:Humans; D006830:Hydralazine / Q000009:adverse effects*; D008297:Male; D008875:Middle Aged; D009395:Nephritis, Interstitial / Q000139:chemically induced / Q000276:immunology*; D009504:Neutrophils / Q000276:immunology; D009195:Peroxidase / Q000276:immunology
D000974:Antibodies, Antinuclear; D006680:HLA Antigens; D006830:Hydralazine; D009195:Peroxidase