[The protective action of nimodipine on the ischemic myocardium].
The experiments with unconscious cats and dogs have demonstrated that the calcium antagonist nimodipine has a profound anti-ischemic property. The drug reduces the average value of ST-segment elevation in multiple epicardial ECG leads, during acute myocardial ischemia. Nimodipine maintains cardiac pump and contractile functions, elevates ATP levels in the arbitrarily intact and ischemic myocardium of the left ventricle during 40-min occlusion and 60-min reperfusion of the coronary artery. The protective action of the drug is unassociated with enhanced collateral coronary circulation.
Tsorin
I B
IB
Kazanova
G V
GV
Kirsanova
G Iu
GIu
Chirkova
E Iu
EIu
Chichkanov
G G
GG
D000818:Animals; D002415:Cats; D003326:Coronary Circulation / Q000187:drug effects / Q000502:physiology; D004285:Dogs; D004305:Dose-Response Relationship, Drug; D004353:Drug Evaluation, Preclinical; D006321:Heart / Q000187:drug effects / Q000503:physiopathology; D006439:Hemodynamics / Q000187:drug effects; D017202:Myocardial Ischemia / Q000188:drug therapy* / Q000503:physiopathology; D009553:Nimodipine / Q000627:therapeutic use*; D013997:Time Factors
D009553:Nimodipine
K zashchitnomu deĭstviiu nimodipina na ishemizirovannyĭ miokard.