title: Presurgical treatment of uterine fibroids by using gonadotropin-releasing hormone agonists.
abstract: Evaluation of clinical intra- and post-operative benefits of pre-myomectomy therapy with a Gonadotropin-Releasing Hormone Agonist (GnRH-A) (Goserelin) in anemic and non-anemic patients suffering from uterine leiomyomas. Evaluation of ultrasound, estradiol (E2) and hematological measurements before and during treatment with a GnRH-a in thirty women with uterine leiomyomas, comparing pre-treated patients operative time, total intraoperative blood loss, blood counts and febrile morbidity with of thirty-five control women. GnRH-A pre-treatment cures, iron-deficiency anemia, significantly reduces myoma and uterine volume (p < 0.01), total intra-operative blood loss (p < 0.001), decreases post-operative febrile morbidity, though it does not reduce operative time. GnRH-A pre-treatment over a period no longer than two months should be suggested in anemic patients suffering from uterine leiomyomas who have to undergo myomectomy.
authors.affiliation: Dept. of Obstetrics and Gynecology, University of Brescia, Italy.
authors.forename: L
authors.initials: L
authors.lastname: Falsetti
authors.forename: M D
authors.initials: MD
authors.lastname: Mazzani
authors.forename: S
authors.initials: S
authors.lastname: Rubessa
authors.forename: C
authors.initials: C
authors.lastname: Ruggeri
mesh_terms: D000740:Anemia / Q000150:complications; D016063:Blood Loss, Surgical / Q000517:prevention & control; D003131:Combined Modality Therapy; D003692:Delayed-Action Preparations; D004958:Estradiol / Q000097:blood; D005260:Female; D005334:Fever; D017273:Goserelin / Q000627:therapeutic use*; D006493:Heparin / Q000627:therapeutic use; D006801:Humans; D007889:Leiomyoma / Q000150:complications / Q000188:drug therapy* / Q000601:surgery; D014594:Uterine Neoplasms / Q000150:complications / Q000188:drug therapy* / Q000601:surgery; D014599:Uterus / Q000187:drug effects / Q000473:pathology
chemical_list: D003692:Delayed-Action Preparations; D017273:Goserelin; D004958:Estradiol; D006493:Heparin