title: [Progressive multifocal leukoencephalopathy in a female patient with chronic lymphatic leukemia].
abstract: This case report describes a 78-year old female patient with chronic lymphocytic leukaemia and neurological symptoms due to progressive multifocal leukoencephalopathy (PML). At autopsy the histopathology was characteristic, the involvement of JC virus was established. PML occurs in immunocompromised patients and is caused by infection with JC papova virus. Epidemiology, clinical course, diagnostic procedures with special reference to the use of the polymerase chain reaction, and therapy are briefly reviewed.
authors.affiliation: Medisch Spectrum Twente, Ziekenhuis Enschede, afd. Inwendige Geneeskunde.
authors.forename: J
authors.initials: J
authors.lastname: Heikens
authors.forename: W
authors.initials: W
authors.lastname: van Berkel
authors.forename: R A
authors.initials: RA
authors.lastname: de Vos
authors.forename: H G
authors.initials: HG
authors.lastname: van der Avoort
authors.forename: M R
authors.initials: MR
authors.lastname: Krul
mesh_terms: D000368:Aged; D001921:Brain / Q000473:pathology; D005260:Female; D006801:Humans; D007577:JC Virus / Q000302:isolation & purification*; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000150:complications*; D007968:Leukoencephalopathy, Progressive Multifocal / Q000150:complications / Q000382:microbiology* / Q000473:pathology
vernacular_title: Progressieve multifocale leuko-encefalopathie bij een patiënte met chronische lymfatische leukemie.