title: The distribution of lymphocyte subpopulations in an infant with primary intestinal lymphangiectasia.
abstract: Authors analysed in an infant with primary intestinal lymphangiectasia the number of intraepithelial lymphocytes and the distribution of T lymphocyte subpopulations in the jejunal mucosa with immunohistochemical methods. It was established that the number of intraepithelial lymphocytes and of the cells belonging to the various T lymphocytes markedly decreased in the patient compared to controls, however the decrease of the CD4 cells was less than that of CD8 cells, thus the CD4/CD8 ratio increased. Authors conclude that the increase of CD4/CD8 ratio in the jejunal mucosa may explain the absence of frequent gut infections in intestinal lymphangiectasia.
authors.affiliation: First Department of Paediatrics, Semmelweis Medical University, Budapest, Hungary.
authors.forename: A
authors.initials: A
authors.lastname: Arató
authors.forename: E
authors.initials: E
authors.lastname: Savilahti
authors.forename: L
authors.initials: L
authors.lastname: Balogh
mesh_terms: D004848:Epithelium / Q000276:immunology; D006801:Humans; D007231:Infant, Newborn; D007413:Intestinal Mucosa / Q000276:immunology*; D007958:Leukocyte Count; D008201:Lymphangiectasis, Intestinal / Q000276:immunology*; D008297:Male; D012016:Reference Values; D016176:T-Lymphocyte Subsets