Evaluation of BACTEC 460 TB system for measurement of in vitro anti-Mycobacterium leprae activity of various antimicrobials.
In vitro anti-leprosy activities of various antimicrobials were measured by using the BACTEC 460 TB System. The Growth Index reducing activities of test drugs were strong in clofazimine, KRM-1648, rifabutin, clarithromycin and rifampicin; intermediate in sparfloxacin, minocycline and ofloxacin; and weak in ciprofloxacin, fleroxacin and DDS. Amikacin, pipemidic acid, enoxacin and norfloxacin had no such in vitro activities. There is a close correlation between in vitro and in vivo anti-M. leprae activities of a given agent, therefore indicating usefulness of the BACTEC 460 TB System in evaluation of in vitro anti-M. leprae activity of a given agent.
Tomioka
H
H
Department of Microbiology and Immunology, Shimane Medical University, Izumo, Japan.
Saito
H
H
Sato
K
K
D000818:Animals; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D004352:Drug Resistance, Microbial; D051379:Mice; D008819:Mice, Nude; D008826:Microbial Sensitivity Tests / Q000379:methods*; D009166:Mycobacterium leprae / Q000187:drug effects*
D000900:Anti-Bacterial Agents