title: Therapeutic modalities in severe infections. Theoretic considerations.
abstract: The advantages of discontinuous versus continuous antibiotherapy are discussed as a therapeutic method in severe infections. The main scientific achievements related to the criteria of discontinuous antibiotherapy are discussed as a therapeutic modality consisting in administration of moderate doses of usual antibiotics every 12th hours. The advantages and disadvantages of the classical continuous and discontinuous antibiotherapies are presented and amply discussed.
authors.affiliation: Second Clinic of Infectious Diseases, Colentina, Romania.
authors.forename: A
authors.initials: A
authors.lastname: Streinu-Cercel
mesh_terms: D000208:Acute Disease; D000900:Anti-Bacterial Agents / Q000008:administration & dosage*; D001424:Bacterial Infections / Q000188:drug therapy* / Q000276:immunology; D004305:Dose-Response Relationship, Drug; D004352:Drug Resistance, Microbial; D006801:Humans; D013997:Time Factors
chemical_list: D000900:Anti-Bacterial Agents