Characterization of the endogenous nonecotropic murine leukemia viruses of NZB/B1NJ and SM/J inbred strains.
We characterized 84 endogenous nonecotropic proviruses of NZB/B1NJ and SM/J inbred strains by examining proviral junction fragment segregation in recombinant inbred (RI) and backcross mice. Forty-five proviruses were shared with other laboratory strains, but 28 were unique to NZB/B1NJ or SM/J. Proviral loci were located on 17 of the 19 mouse autosomes and on both sex chromosomes. These markers will facilitate gene mapping in the NXSM RI set and contribute to the pursuit of a more complete map of the mouse genome.
Frankel
W N
WN
Department of Molecular Biology, Tufts University School of Medicine, Boston, Massachusetts 02111.
Lee
B K
BK
Stoye
J P
JP
Coffin
J M
JM
Eicher
E M
EM
D000818:Animals; D015139:Blotting, Southern; D003433:Crosses, Genetic; D005260:Female; D008040:Genetic Linkage; D009052:Leukemia Virus, Murine / Q000235:genetics*; D008297:Male; D051379:Mice; D008814:Mice, Inbred NZB; D008815:Mice, Inbred Strains; D011533:Proviruses / Q000235:genetics; D015183:Restriction Mapping; D016662:Virus Integration / Q000235:genetics