title: Acute renal failure occurring during intravenous desferrioxamine therapy: recovery after haemodialysis.
abstract: A patient with transfusion-dependent thalassemia was undergoing home intravenous desferrioxamine (DFX) treatment by means of a totally implanted system because of his poor compliance with the nightly subcutaneous therapy. Due to an accidental malfunctioning of the infusion pump, the patient was inadvertently administered a toxic dosage of the drug which caused renal insufficiency. Given the progressive deterioration of the symptoms and of the laboratory values, despite adequate medical treatment, a decision was made to introduce haemodialytical therapy in order to remove the drug and therapy reduce the nephrotoxicity. From the results obtained, haemodialysis can therefore be suggested as a useful therapy in rare cases of progressive acute renal failure caused by desferrioxamine.
authors.affiliation: Cattedra di Ematologia, Ospedale S. Eugenio, Roma, Italy.
authors.forename: P
authors.initials: P
authors.lastname: Cianciulli
authors.forename: F
authors.initials: F
authors.lastname: Sorrentino
authors.forename: L
authors.initials: L
authors.lastname: Forte
authors.forename: M
authors.initials: M
authors.lastname: Palombi
authors.forename: G
authors.initials: G
authors.lastname: Papa
authors.forename: C
authors.initials: C
authors.lastname: Meloni
authors.forename: M
authors.initials: M
authors.lastname: Taccone Gallucci
authors.forename: C U
authors.initials: CU
authors.lastname: Casciani
mesh_terms: D058186:Acute Kidney Injury / Q000139:chemically induced* / Q000628:therapy; D000328:Adult; D015913:Chelation Therapy / Q000009:adverse effects*; D003676:Deferoxamine / Q000008:administration & dosage / Q000009:adverse effects*; D062787:Drug Overdose; D004868:Equipment Failure; D006699:Home Care Services; D006801:Humans; D015918:Infusion Pumps, Implantable; D007262:Infusions, Intravenous / Q000295:instrumentation; D008297:Male; D006435:Renal Dialysis; D017086:beta-Thalassemia / Q000150:complications* / Q000188:drug therapy
chemical_list: D003676:Deferoxamine