[The effect of leucine enkephalin on the development of a convulsive afterdischarge in the sensorimotor cortex of rats].
The application of leucin-enkephalin solution (LEU) (2 micrograms/2 microliters) on stimulated region of sensomotor cortex did not influence threshold of direct and transcallosal cortex responses (DR and TCR). On coupling of repeated electrostimulation train (RET) (duration of impulse--0.1 ms; duration of train--10 s; frequency--10/s) with application of LEU (after every odd train) the changes of DR and TCR in course of even trains and latency of afterdischarge appearance were such as in control ones. Simultaneously LEU effectively depressed short posttetanic potentiation of DR and TCR and potentiation of amplitude and duration AD, evoked by RET. It is suggested that LEU released from neurons in the course of RET does not participate in initiation of seizure in sensomotor cortex. A possible role of LEU in sensomotor cortex is limitation of intensity and duration of seizures and prevention of status epilepticus.
Kryzhanovskiĭ
G N
GN
Lutsenko
V K
VK
Khlebnikova
N N
NN
D000818:Animals; D004558:Electric Stimulation / Q000379:methods; D004743:Enkephalin, Leucine / Q000494:pharmacology*; D005071:Evoked Potentials / Q000187:drug effects / Q000502:physiology; D008297:Male; D009044:Motor Cortex / Q000187:drug effects* / Q000502:physiology; D009474:Neurons / Q000187:drug effects / Q000502:physiology; D051381:Rats; D011930:Reaction Time / Q000187:drug effects / Q000502:physiology; D012640:Seizures / Q000503:physiopathology*
D004743:Enkephalin, Leucine
Vliianie leĭtsin-énkefalina na razvitie sudorozhnogo sledovogo razriada v sensomotornoĭ kore krys.