Synaptosomal membrane fluidity, lipid peroxidation and superoxide dismutase activity in the brain of amygdala-kindled rats.
Synaptosomal membrane fluidity, lipid peroxide (LPO) and cytosolic superoxide dismutase (SOD) activity were examined in various brain regions (amygdala, hippocampus, striatum and frontal cortex) of amygdala-kindled rats. At 24 h after the last seizure, a significant increase of membrane fluidity was observed in all the regions examined, whereas the LPO level was significantly decreased in the four regions with enhanced activity of cytosolic SOD. At 7 days after the last seizure, membrane fluidity was decreased only in the hippocampus. At 6 weeks after the last seizure, there were no changes in membrane fluidity between control and kindled rats. These results suggest that membrane fluidity and lipid peroxidation are modulated transiently by a kindled seizure, but not at a steady state of kindling with enduring seizure susceptibility.
Itoh
T
T
Department of Neuropsychiatry, Okayama University Medical School, Japan.
Akiyama
K
K
Hiramatsu
M
M
Otsuki
S
S
D000679:Amygdala; D000818:Animals; D001921:Brain / Q000201:enzymology / Q000378:metabolism*; D007696:Kindling, Neurologic / Q000378:metabolism*; D015227:Lipid Peroxidation; D008297:Male; D008560:Membrane Fluidity; D051381:Rats; D017207:Rats, Sprague-Dawley; D013482:Superoxide Dismutase / Q000378:metabolism*; D013574:Synaptosomes / Q000378:metabolism*
D013482:Superoxide Dismutase