[Importance of the role of dose rate on tumor induction in rats after radon inhalation].
Lung cancer can be induced in rats, by radon daughter products, after exposure as low as 25 WLM (80 mJ.h.m-3) protracted over 4 to 6 months with a dose rate of 100 to 150 WL (2 to 3 mJ.m-3). The incidence of lung cancer is not increased and is equal to that of controls when the same cumulated dose is protracted over 18 months at 2 WL (0.042 mJ.m-3).
Morlier
J P
JP
C.E.A.-C.E.N.F.A.R., Fontenay-aux-Roses.
Morin
M
M
Chameaud
J
J
Masse
R
R
Bottard
S
S
Lafuma
J
J
D000280:Administration, Inhalation; D000818:Animals; D004307:Dose-Response Relationship, Radiation; D008175:Lung Neoplasms / Q000453:epidemiology / Q000209:etiology*; D008297:Male; D009381:Neoplasms, Radiation-Induced / Q000453:epidemiology / Q000209:etiology*; D011886:Radon / Q000008:administration & dosage* / Q000009:adverse effects*; D051381:Rats; D017207:Rats, Sprague-Dawley
D011886:Radon
Importance du rôle du débit de dose sur l'apparition des cancers chez le rat après inhalation de radon.