[The significance of the determination of AFP-isoform in the early diagnosis of hepatocellular carcinoma].
To evaluate the significance of the determination of the AFP-isoform in the early diagnosis of hepatocellular carcinoma (HCC), the AFP-isoform was determined in 48 patients with HCC and in 53 patients with liver cirrhosis, using the lectin electrophoresis of AFP by antibody-affinity blotting technique. 1. The HCC-type AFP-isoform was detected in 44 of the 48 patients with HCC, 2. In about 30% of the patients with HCC, the HCC-type AFP-isoform appeared 3-10 months before the graphic diagnosis of HCC, 3. In about 60% of the patients with liver cirrhosis found to have the HCC-type AFP-isoform, HCC developed within one year. Thus, the serial determination of the AFP-isoform in patients with liver cirrhosis was considered very useful for the early diagnosis of HCC.
Ishizuka
H
H
Department of Internal Medicine, Nihon University School of Medicine, Tokyo.
Arakawa
Y
Y
Nakano
E
E
D006528:Carcinoma, Hepatocellular / Q000175:diagnosis*; D006801:Humans; D008103:Liver Cirrhosis / Q000378:metabolism; D008113:Liver Neoplasms / Q000175:diagnosis*; D000509:alpha-Fetoproteins / Q000032:analysis* / Q000737:chemistry
D000509:alpha-Fetoproteins