title: [Interhemispheric transfer in multiple sclerosis. Morphofunctional correlations].
abstract: Signs of cerebral disconnection, especially left ear suppression to dichotically presented verbal stimuli, have been reported in multiple sclerosis patients and found to be correlated to morphological atrophy of the corpus callosum on magnetic resonance imaging. To reinvestigate this issue, 26 patients satisfying criteria for definite multiple sclerosis were proposed 3 tasks aimed at evaluating interhemispheric function: a dichotic listening task, a motor finger-tapping task and a sensory transfer task. Performance at these tasks suggested impaired callosal function in MS patients, compared to normal controls. Callosal morphology was assessed on midsagittal MRI sections using a digitalised method of partition of the callosal area into 6 subregions and automatized surface measurements. Results of correlations between task performance and callosal areas showed a significant correlation between total callosal atrophy and severity of interhemispheric impairment on each functional task. Moreover, impaired motor transfer was specifically related to atrophy of the anterior callosal regions. These results suggest that MS patients may constitute a suitable population to studying interhemispheric transfer of information through the callosal commissure and that this approach may be useful in the clinical management of MS patients.
authors.affiliation: Clinique de Neurologie, CHU Timone, Marseille.
authors.forename: J
authors.initials: J
authors.lastname: Pelletier
authors.forename: M
authors.initials: M
authors.lastname: Habib
authors.forename: M
authors.initials: M
authors.lastname: Brouchon
authors.forename: M
authors.initials: M
authors.lastname: Poncet
authors.forename: O
authors.initials: O
authors.lastname: Lyon-Caen
authors.forename: G
authors.initials: G
authors.lastname: Salamon
authors.forename: R
authors.initials: R
authors.lastname: Khalil
mesh_terms: D000293:Adolescent; D000328:Adult; D001284:Atrophy; D003337:Corpus Callosum / Q000473:pathology / Q000503:physiopathology; D004007:Dichotic Listening Tests; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008606:Mental Processes; D008875:Middle Aged; D009103:Multiple Sclerosis / Q000473:pathology / Q000503:physiopathology*; D009483:Neuropsychological Tests
vernacular_title: Etude du transfert interhémisphérique dans la sclérose en plaques. Corrélations morpho-fonctionnelles.