[The reactivity of the skeletal muscle arterioles of rats to noradrenaline after whole-body gamma irradiation at a dose of 1 Gy].
Male Wistar rats were exposed by total gamma-irradiation at 1 Gy, Reactions of skeletal muscle arterioles and mean arterial pressure on intravenous doses of noradrenaline (0.1, 0.3, 1.0 and 3.0 micrograms/kg) was studied by intravital microscopy in acute experiments 1, 3 and 5-6 days after irradiation. The exposure causes arterial hypotension on day 1 after that as well as marked reduction of spontaneous arteriole vasomotions and decrease of arteriole constrictions at any doses and dates under study. There are no differences of arterial pressure reaction amplitudes in per cent between control and exposed animals at any doses and dates under investigation.
Zakharov
A G
AG
Ivanov
L S
LS
Khmelevskiĭ
E V
EV
Bozhenko
V K
VK
D000818:Animals; D001160:Arterioles / Q000187:drug effects / Q000528:radiation effects; D001783:Blood Flow Velocity / Q000187:drug effects / Q000528:radiation effects; D001794:Blood Pressure / Q000187:drug effects / Q000528:radiation effects; D004305:Dose-Response Relationship, Drug; D004307:Dose-Response Relationship, Radiation; D005720:Gamma Rays; D008297:Male; D009132:Muscles / Q000098:blood supply / Q000187:drug effects* / Q000528:radiation effects*; D009638:Norepinephrine / Q000494:pharmacology*; D051381:Rats; D013997:Time Factors; D014916:Whole-Body Irradiation
D009638:Norepinephrine
Reaktivnost' arteriol skeletnoĭ myshtsy krys k noradrenalinu posle omshchego gamma-oblucheniia dozoĭ 1 Gr.