[The effect of cyclosporin A on the islet cells of mice].
The action of immunosuppressive agent ciclosporin A on the insular apparatus was studied with an original method of cytochemical zinc detection in experiments on mice. The drug was found to lower zinc levels in pancreatic beta-cells. In ciclosporin A pretreatment the sensitivity of mice to zinc-binding diabetogenic agent enhanced.
Gol'dberg
E D
ED
Eshchenko
V A
VA
Bovt
V D
VD
Tolok
A Ia
AIa
D000634:Aminoquinolines / Q000494:pharmacology; D000818:Animals; D001786:Blood Glucose / Q000032:analysis / Q000187:drug effects; D016572:Cyclosporine / Q000494:pharmacology*; D006651:Histocytochemistry; D007515:Islets of Langerhans / Q000187:drug effects* / Q000378:metabolism; D008163:Luminescent Measurements; D051379:Mice; D013449:Sulfonamides / Q000494:pharmacology; D013997:Time Factors; D014105:Tosyl Compounds
D000634:Aminoquinolines; D001786:Blood Glucose; D013449:Sulfonamides; D014105:Tosyl Compounds; C031480:8-(4-tolylsulfonylamino)quinoline; D016572:Cyclosporine
Vliianie tsiklosporina A na insuliarnyĭ apparat mysheĭ.