Prevention of development of tolerance and dependence to opiate in mice by BR-16A (Mentat), a herbal psychotropic preparation.
Chronic treatment with BR-16A (20-500 mg/kg) followed by saline on days 1 to 9 failed to produce any significant change in tail-flick latency from the saline-pretreated group in mice. Repeated administration of BR-16A(20-500 mg/kg) for 9 days however, attenuated the development of tolerance to the analgesic effect of morphine (10 mg/kg). BR-16A (20-500 mg/kg) also suppressed, in a dose-dependent manner, the development of morphine dependence as assessed by naloxone (2 mg/kg)-precipitated withdrawal on day 10 of testing.
Kulkarni
S K
SK
Department of Pharmaceutical Sciences, Panjab University, Chandigarh, India.
Verma
A
A
D000704:Analysis of Variance; D000818:Animals; D004305:Dose-Response Relationship, Drug; D004361:Drug Tolerance; D005260:Female; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D009020:Morphine; D010936:Plant Extracts / Q000627:therapeutic use*; D010946:Plants, Medicinal; D011619:Psychotropic Drugs / Q000627:therapeutic use*; D013375:Substance Withdrawal Syndrome / Q000188:drug therapy; D019966:Substance-Related Disorders / Q000517:prevention & control*
C074754:Mentat; D010936:Plant Extracts; D011619:Psychotropic Drugs; D009020:Morphine