[Effect of loratadine (LO), a selective H1 antagonist, on histamine-induced bronchoconstriction].
The influence of single and repeated LO (10 mg/day) doses on histamine-induced bronchoconstriction was studied in 11 patients with stabile bronchial asthma. Bronchial reactivity was estimated as histamine content potent to elicit a 20% FEV, fall, i.e. PC20H. A single dose gave a significant (5.5 fold) reduction in bronchial reactivity to inhaled histamine. Application of LO during 6 days gave a similar effect. Withdrawal of LO for 6 days yielded an increase in bronchial hyperreactivity.
Grzelewska-Rzymowska
I
I
Kliniki Pneumonologii i Alergologii IMW AM, Lodzi.
Gondorowicz
K
K
Cieślewicz
G
G
Rozniecki
J
J
Wojciechowska
B
B
D000328:Adult; D001249:Asthma / Q000175:diagnosis / Q000188:drug therapy*; D001985:Bronchial Provocation Tests; D016084:Bronchoconstriction / Q000187:drug effects*; D005260:Female; D006632:Histamine; D006801:Humans; D017336:Loratadine / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged
D017336:Loratadine; D006632:Histamine
Wpływ loratadyny, wybiórczego antagonisty receptorów histaminowych (H1), na skurcz oskrzeli wywołany wziewaniem histaminy.