[Clinical and molecular basis of androgen resistance].
Androgen resistance is responsible for the development of a spectrum of abnormalities of male sexual differentiation, and can be broadly divided in two categories: deficiency of 5-alpha-reductase and defects in the androgen receptor. Recent developments in the field on molecular biology have allowed the cloning and characterization of the genes responsible for both syndromes and have made it possible to detect the subtle molecular defects underlying these diseases. This discussion will review some of the most recent development in this field of research.
Marcelli
M
M
Department of Internal Medicine, Baylor College of Medicine, Houston.
McPhaul
M J
MJ
D000727:Androgen-Binding Protein / Q000235:genetics; D013734:Androgen-Insensitivity Syndrome / Q000175:diagnosis* / Q000235:genetics; D000728:Androgens / Q000235:genetics; D001665:Binding Sites; D004268:DNA-Binding Proteins / Q000235:genetics; D015914:Estrogen Replacement Therapy; D005091:Exons / Q000235:genetics; D005347:Fibroblasts; D006801:Humans; D008297:Male; D009154:Mutation / Q000235:genetics; D010088:Oxidoreductases / Q000172:deficiency / Q000235:genetics; D011944:Receptors, Androgen / Q000235:genetics
D000727:Androgen-Binding Protein; D000728:Androgens; D004268:DNA-Binding Proteins; D011944:Receptors, Androgen; D010088:Oxidoreductases
Basi cliniche e molecolari delle sindromi da androgeno-resistenza.