Antimetabolites in the surgical treatment of glaucomas.
Fibroblast proliferation with scarring at the surgical site plays an important role in the failure of filtration surgery. Several antimetabolites inhibit fibroblast proliferation in vitro. These observations have lead to the widespread clinical use in humans of 5-fluorouracil and more recently mitomycin-C in glaucoma filtering surgery.
Van Oye
R
R
University Hospital of Ghent, Department of Ophthalmology, Belgium.
Van Caelenberghe
E
E
D000818:Animals; D016645:Aotidae; D002455:Cell Division / Q000187:drug effects; D005347:Fibroblasts / Q000502:physiology; D005472:Fluorouracil / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D005901:Glaucoma / Q000188:drug therapy / Q000601:surgery*; D006801:Humans; D007429:Intraocular Pressure / Q000187:drug effects; D011183:Postoperative Complications / Q000188:drug therapy*
D005472:Fluorouracil