Endogenous Xenopus-oocyte Ca-channels are regulated by protein kinases A and C.
Calcium entry into Xenopus oocyte occurs mainly through voltage-dependent calcium channels. These channels were characterized as belonging to a particular type of calcium channel insensitive to dihydropyridines, omega-conotoxin, and Agelenopsis aperta venom, but blocked by divalent cations (Co, Cd, Ni). Intracellular injection of cAMP, or bath application of phorbol ester, induced a marked increase in calcium current amplitude and a slowing of the inactivation time-course. Despite their different pharmacology, endogenous calcium channels, like cardiac or neuronal calcium channels, could be thus regulated by protein kinases A and C.
Bourinet
E
E
CNRS-CRBM, Montpellier, France.
Fournier
F
F
Nargeot
J
J
Charnet
P
P
D000818:Animals; D015220:Calcium Channels / Q000378:metabolism* / Q000502:physiology; D004594:Electrophysiology; D004789:Enzyme Activation; D007700:Kinetics; D009865:Oocytes / Q000378:metabolism*; D011493:Protein Kinase C / Q000378:metabolism*; D011494:Protein Kinases / Q000378:metabolism*; D014982:Xenopus laevis
D015220:Calcium Channels; D011494:Protein Kinases; D011493:Protein Kinase C