[The effect of potential beta-adrenolytic agents on oxidation and phosphorylation processes in myocardial muscle mitochondria in vitro].
Concentrations ranging from 1-9 x 10(-7) mol.dm-3 were employed for in vitro studies. Under the selected experimental conditions, both agents markedly decreased the stimulated consumption of oxygen by the cardiac muscle mitochondria in the condition S3, the rate of the formation of energy by mitochondria as well as the respiratory control index. The coefficient of oxidative phosphorylation was not markedly changed due to the effect of the added agents. The results of the present paper suggest possible integration of the cardiac muscle mitochondria in the oxidative metabolism of the potential beta-adrenolytic agents FA33 and FP33, which requires further in vivo studies.
Cizmáriková
R
R
Katedra anorganickej a organickej chémie Farmaceutickej fakulty, Univerzity Komenského, Bratislava.
Gvozdjaková
A
A
Kucharská
J
J
D000098:Acetophenones / Q000494:pharmacology*; D000818:Animals; D066298:In Vitro Techniques; D008297:Male; D008929:Mitochondria, Heart / Q000378:metabolism*; D010085:Oxidative Phosphorylation / Q000187:drug effects*; D011412:Propanolamines / Q000494:pharmacology*; D011427:Propiophenones / Q000494:pharmacology*; D011817:Rabbits
D000098:Acetophenones; D011412:Propanolamines; D011427:Propiophenones; C079448:4-(3-isopropylamino-2-hydroxypropoxy)-3-(propoxymethyl)acetophenone; C079934:FP 33
Ucinok potenciálnych beta-adrenolytík na oxidacné a fosforylacné procesy mitochondrií srdcového svalu in vitro.