[The assessment of the hormonal sensitivity of tumors of the large intestine in the adenylate cyclase test].
Sensitivity of 142 human large bowel malignancies to gastroenteropancreatic hormones (VIP, glucagon and pentogastrin) and calcitonin was studied using in vitro adenylate cyclase reaction of tumor. At least 40-55% of the tumors proved hormone sensitive. Heteroresponse (reaction to calcitonin) was most characteristic for colonic tumors whereas weak reaction to VIP and glucagon-for rectal neoplasms. A certain relationship was established between adenylate cyclase reaction to hormone stimulation, on the one hand, and peculiarities of tumor (degree of cell differentiation) and the body (gender), on the other. In patients who survived over 4 years, tumor adenylate cyclase had initially been more sensitive to hormone stimulation than in those who died over that period. It is concluded that tumor adenylate cyclase reaction to hormone stimulation is quite a reliable test for evaluating hormone sensitivity of large bowel tumors and, possibly, for choosing hormonal therapy.
Bershteĭn
L M
LM
Pravosudov
I V
IV
Kovaleva
I G
IG
Kriukova
O G
OG
D000230:Adenocarcinoma / Q000188:drug therapy* / Q000201:enzymology / Q000401:mortality; D000262:Adenylyl Cyclases / Q000187:drug effects*; D000328:Adult; D000368:Aged; D002277:Carcinoma / Q000188:drug therapy* / Q000201:enzymology / Q000401:mortality; D003110:Colonic Neoplasms / Q000188:drug therapy* / Q000201:enzymology / Q000401:mortality; D004354:Drug Screening Assays, Antitumor; D005260:Female; D005768:Gastrointestinal Hormones / Q000627:therapeutic use*; D006801:Humans; D007413:Intestinal Mucosa / Q000187:drug effects / Q000201:enzymology; D007420:Intestine, Large / Q000187:drug effects / Q000201:enzymology; D008297:Male; D008875:Middle Aged; D009378:Neoplasms, Multiple Primary / Q000188:drug therapy* / Q000201:enzymology / Q000401:mortality; D012004:Rectal Neoplasms / Q000188:drug therapy* / Q000201:enzymology / Q000401:mortality; D012727:Sex Characteristics
D005768:Gastrointestinal Hormones; D000262:Adenylyl Cyclases
Otsenka gormonochuvstvitel'nosti opukholeĭ tolstoĭ kishki v adenilattsiklaznom teste.