The involvement of polymorphonuclear leukocytes in the pathogenesis of bronchopneumonia in calves. VII. Granulocyte activation by arachidonic acid.
Arachidonic acid-induced granulocyte activation was studied in calves. Both in healthy and in bronchopneumonic animals, neutrophil stimulation with 67 microM arachidonic acid caused a rise in granulocyte exocytosis. This event, however, was much more intense in granulocytes from diseased calves. Fatty acids were found to stimulate granule exocytosis from granulocytes. Oleic acid possessed the weakest while dihomo-gamma-linoleic acid showed the strongest activity of this type. It is suggested that arachidonic acid may be an important mediator of calf bronchopneumonia.
Ledwozyw
A
A
Department of Pathophysiology, Veterinary Faculty, Agricultural Academy, Lublin, Poland.
Ruciński
T
T
Stolarczyk
H
H
Siwek
A
A
D000818:Animals; D016718:Arachidonic Acid / Q000494:pharmacology*; D001996:Bronchopneumonia / Q000276:immunology / Q000662:veterinary*; D002417:Cattle; D002418:Cattle Diseases / Q000276:immunology*; D015550:Cell Degranulation / Q000187:drug effects; D002478:Cells, Cultured; D009504:Neutrophils / Q000187:drug effects / Q000378:metabolism*
D016718:Arachidonic Acid