[The characteristics of the alpha-adrenergic regulation of the cardiovascular system in middle-aged and elderly subjects].
97 practically healthy young adult, elderly and old people were examined to study the age-associated changes in alpha-adrenergic regulation of the cardiovascular system. The values of central and renal hemodynamics, systolic and diastolic cardiac functions, skin and bulbar microcirculation and arterial blood pressure were determined in dynamics after injection of the alpha-stimulator phenylephrine (0.15 mg/kg of body mass intramuscularly) or alpha-blocker prazosin (0.015 mg/kg of body mass orally). In old age alpha-adrenergic effects on the heart were found to decrease. In elderly and old people the changes of peripheric blood circulation prevail in the structure of hemodynamic shifts arising in stimulation and alpha-adrenergic receptors blockage.
Korkushko
O V
OV
Sarkisov
K H
KH
Shatylo
V B
VB
Moroz
H Z
HZ
Mistriukov
V M
VM
Tarasenko
O B
OB
D000328:Adult; D000368:Aged; D000375:Aging / Q000187:drug effects / Q000502:physiology*; D002320:Cardiovascular Physiological Phenomena; D002319:Cardiovascular System / Q000187:drug effects; D006439:Hemodynamics / Q000187:drug effects / Q000502:physiology; D006801:Humans; D008875:Middle Aged; D010656:Phenylephrine / Q000494:pharmacology; D011224:Prazosin / Q000494:pharmacology; D011942:Receptors, Adrenergic, alpha / Q000187:drug effects / Q000502:physiology*; D012016:Reference Values; D012079:Renal Circulation / Q000187:drug effects / Q000502:physiology; D013997:Time Factors; D016277:Ventricular Function, Left / Q000187:drug effects / Q000502:physiology
D011942:Receptors, Adrenergic, alpha; D010656:Phenylephrine; D011224:Prazosin
Osoblyvosti al'fa-adrenerhichnoï rehuliatsiï sertsevo-sudynnoï systemy u liudeĭ pokhyloho i staroho viku.