title: The in vitro and in vivo biotransformation of N-deacetyl-N-formylcolchicine.
abstract: The major pathway of metabolic transformation of N-deacetyl-N-formylcolchicine is the oxidative cytochrome P450 dependent O-demethylation of substituents in the aromatic ring A and tropolone ring C. It was found that O-demethylation (both, in vitro and in vivo) takes place predominantly in the aromatic ring, especially at position 2.
authors.affiliation: Institute of Chemistry, Faculty of Sciences, University of Novi Sad, Yugoslavia.
authors.forename: V
authors.initials: V
authors.lastname: Lukić
authors.forename: A
authors.initials: A
authors.lastname: Husek
authors.forename: O
authors.initials: O
authors.lastname: Gasić
authors.forename: D
authors.initials: D
authors.lastname: Walterova
authors.forename: V
authors.initials: V
authors.lastname: Simanek
mesh_terms: D000818:Animals; D001711:Biotransformation; D003078:Colchicine / Q000031:analogs & derivatives* / Q000493:pharmacokinetics*; D003640:Dealkylation; D066298:In Vitro Techniques; D008297:Male; D008862:Microsomes, Liver / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar
chemical_list: C080994:N-deacetyl-N-formylcolchicine; D003078:Colchicine