SPECT imaging of serotonin2 receptors in depression.
Changes of serotonin2 (5HT2) receptors have been described in depression, and long-term antidepressant treatment has been shown to decrease the number of 5HT2 receptors. In this study, single photon emission computed tomography (SPECT), with 2-123I-ketanserin as a ligand, was used to investigate 5HT2 receptors in vivo in the brain of depressed patients and normal volunteers. A higher uptake of the tracer was observed in the parietal cortex of the patients, and there was a right greater than left asymmetry in the infero-frontal region of the depressed subjects and not in that of the control subjects. These findings could indicate changes in 5HT2 receptors in major depression.
D'haenen
H
H
Department of Psychiatry, Academic Hospital, Brussels, Belgium.
Bossuyt
A
A
Mertens
J
J
Bossuyt-Piron
C
C
Gijsemans
M
M
Kaufman
L
L
D000293:Adolescent; D000328:Adult; D000368:Aged; D001921:Brain / Q000000981:diagnostic imaging* / Q000503:physiopathology; D001931:Brain Mapping; D002540:Cerebral Cortex / Q000000981:diagnostic imaging / Q000503:physiopathology; D003866:Depressive Disorder / Q000000981:diagnostic imaging* / Q000503:physiopathology; D004292:Dominance, Cerebral / Q000502:physiology; D005260:Female; D006801:Humans; D007650:Ketanserin / Q000493:pharmacokinetics; D008297:Male; D008875:Middle Aged; D010296:Parietal Lobe / Q000000981:diagnostic imaging / Q000503:physiopathology; D011985:Receptors, Serotonin / Q000502:physiology*; D015899:Tomography, Emission-Computed, Single-Photon
D011985:Receptors, Serotonin; D007650:Ketanserin