title: Differential effects of left versus right seizure focus on human hippocampal evoked responses.
abstract: Hippocampal evoked potentials were recorded using the P3 tonal oddball paradigm in 30 patients with unilateral temporal lobe seizure focus. Spectral power of the evoked potentials was decreased on the side of seizure focus, but this reduction was much greater when the focus was on the left. The effect of left/right focus does not appear to be due to group differences in age, sex, seizure duration, or operative pathology. Remote or finer left/right structural differences or differential left/right hippocampal processing for the sequential tonal task are possible explanations.
authors.affiliation: Department of Neurology, Medical College of Georgia, Augusta 30912-3200.
authors.forename: K J
authors.initials: KJ
authors.lastname: Meador
authors.forename: D W
authors.initials: DW
authors.lastname: Loring
authors.forename: B B
authors.initials: BB
authors.lastname: Gallagher
authors.forename: D W
authors.initials: DW
authors.lastname: King
authors.forename: A M
authors.initials: AM
authors.lastname: Murro
authors.forename: E E
authors.initials: EE
authors.lastname: Thompson
authors.forename: G P
authors.initials: GP
authors.lastname: Lee
authors.forename: H F
authors.initials: HF
authors.lastname: Flanigin
authors.forename: J R
authors.initials: JR
authors.lastname: Smith
authors.forename: J
authors.initials: J
authors.lastname: Dushku
mesh_terms: D000293:Adolescent; D000328:Adult; D000375:Aging / Q000502:physiology; D004567:Electrodes, Implanted; D004833:Epilepsy, Temporal Lobe / Q000503:physiopathology*; D005072:Evoked Potentials, Auditory / Q000502:physiology*; D005260:Female; D007839:Functional Laterality / Q000502:physiology*; D006624:Hippocampus / Q000503:physiopathology*; D006801:Humans; D008032:Limbic System / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D012727:Sex Characteristics; D013238:Stereotaxic Techniques