[Changes in the properties of the 5-HT1 receptors in the brains of rats, the progeny of parents consuming morphine for a long time].
Studies were performed in two-month rats whose parents had been given morphine for a long period before mating. Considerable changes were found in the properties of rat brain 5-HT1 receptors, which manifested as increased number of ligand binding sites (Bmax) and higher KD, which indicates a lower receptor affinity for ligand. Single morphine administration to the animals caused normalization of the properties of the receptors.
Vekshina
N L
NL
Khristoliubova
N A
NA
D000818:Animals; D001921:Brain / Q000187:drug effects* / Q000378:metabolism; D001923:Brain Chemistry / Q000187:drug effects; D002540:Cerebral Cortex / Q000737:chemistry / Q000187:drug effects; D002908:Chronic Disease; D005260:Female; D008297:Male; D009021:Morphine Dependence / Q000378:metabolism*; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects; D011869:Radioligand Assay; D051381:Rats; D011985:Receptors, Serotonin / Q000032:analysis / Q000187:drug effects*
D011985:Receptors, Serotonin
Izmenenie svoĭstv 5-HT1-retseptorov mozga u krys--potomkov roditeleĭ, dlitel'no potrebliavshikh morfin.