title: Angiodysplasia and von Willebrand's disease type IIB treated with estrogen/progesterone therapy.
abstract: The association between angiodysplasia and von Willebrand's disease was first reported in 1967. The cases reported to date have involved patients with type I and IIA von Willebrand's disease. We report a patient with type IIB von Willebrand's disease who suffered gastrointestinal bleeding attributable to gastric angiodysplasia. The patient underwent endoscopic electrocautery acutely and has been treated long-term with estrogen/progesterone therapy. She has suffered no recurrent gastrointestinal bleeding at over 11 months of follow-up. We suggest hormonal therapy as an alternative to repeated blood product transfusion or extensive surgical resection in patients with von Willebrand's disease and gastrointestinal bleeding from angiodysplasia.
authors.affiliation: Division of Gastroenterology, University of Michigan Medical School, Ann Arbor 48109-0362.
authors.forename: W D
authors.initials: WD
authors.lastname: Chey
authors.forename: W L
authors.initials: WL
authors.lastname: Hasler
authors.forename: P L
authors.initials: PL
authors.lastname: Bockenstedt
mesh_terms: D001165:Arteriovenous Malformations / Q000150:complications / Q000188:drug therapy*; D004359:Drug Therapy, Combination; D004564:Electrocoagulation; D004958:Estradiol / Q000627:therapeutic use*; D005260:Female; D006471:Gastrointestinal Hemorrhage / Q000209:etiology / Q000628:therapy; D005773:Gastroscopy; D006801:Humans; D008525:Medroxyprogesterone / Q000627:therapeutic use*; D008875:Middle Aged; D013270:Stomach / Q000098:blood supply* / Q000473:pathology; D014842:von Willebrand Diseases / Q000150:complications / Q000188:drug therapy*
chemical_list: D004958:Estradiol; D008525:Medroxyprogesterone