[Relation between 67-gallium scintigraphy and bronchoalveolar lavage--differential cell count and superoxide anion liberation--in patients with systemic scleroderma and systemic lupus erythematosus].
The aim of the study was to determine the pulmonary 67-gallium uptake, bronchoalveolar lavage (BAL) cell differentiation and the activity of BAL cells, measured as release of superoxide anion (O2-), and to investigate the results whether there are relations. In 11 nonsmoking systemic scleroderma (SS) patients and 11 systemic lupus erythematosus (SLE) patients with lung involvement double-sided BAL were performed, mainly in regions with increased 67-gallium uptake. Release of O2- was measured by INT-assey. BAL cell differentiation was in SS and SLE pathological in 68.2% without side-difference. In contrast to SS, O2(-)-release in SLE depends on BAL cell differentiation and is most increased in normal BAL cell differentiation. There is no correlation between 67-gallium uptake and both BAL cell differentiation and O2(-)-release. The results suggest, that in contrast to SS, BAL cells in SLE with pathological differentiation are less activated than BAL cells with normal differentiation probable due to autoimmunological factors. Pulmonary 67-gallium scan and BAL seem to be independent from each other.
Witt
C
C
Klinik für Innere Medizin, Medizinischen Fakultät (Charité), Humboldt-Universität zu Berlin.
Apostoloff
E
E
Müller
G M
GM
Buchali
K
K
Hiepe
F
F
Brenke
A
A
Romberg
B
B
Winsel
K
K
D000328:Adult; D001992:Bronchoalveolar Lavage Fluid / Q000737:chemistry / Q000166:cytology*; D005260:Female; D005710:Gallium Radioisotopes; D006801:Humans; D007958:Leukocyte Count; D008180:Lupus Erythematosus, Systemic / Q000175:diagnosis*; D008297:Male; D008875:Middle Aged; D011658:Pulmonary Fibrosis / Q000175:diagnosis*; D012595:Scleroderma, Systemic / Q000175:diagnosis*; D013481:Superoxides / Q000032:analysis*
D005710:Gallium Radioisotopes; D013481:Superoxides
Beziehungen zwischen 67-Gallium-Szintigraphie und bronchoalveolärer Lavage--Differentialzellbild und Superoxid-Anion-Freisetzung--bei Patienten mit systemischer Sklerodermie und systemischem Lupus erythematodes.