title: Effect of ipratropium bromide in bronchial asthma.
abstract: The effect of inhalation of ipratropium bromide was evaluated in 20 patients with bronchial asthma. It was observed that there was no significant improvement in the forced vital capacity and the forced expired volume in one second, while there was significant improvement in the peak expiratory flow rate (PEFR) measured at 9 pm, after inhalation of 2 puffs of ipratropium bromide aerosol (0.02mg/puff) three to four times a day for 2 weeks. Since PEFR is a measure of large airway function and cholinergic mechanisms are primarily involved for airflow obstruction at large airways, improvement in PEFR by ipratropium bromide highlights its role as a useful bronchodilator in patients in whom vagal reflexes are responsible for the provocation of bronchoconstriction.
authors.affiliation: Dept of Respiratory Medicine, KEM Hospital, Parel, Bombay, Maharashtra.
authors.forename: V
authors.initials: V
authors.lastname: Taskar
authors.forename: L
authors.initials: L
authors.lastname: Mirchandani
authors.forename: A A
authors.initials: AA
authors.lastname: Mahashur
authors.forename: R R
authors.initials: RR
authors.lastname: Sharma
authors.forename: V P
authors.initials: VP
authors.lastname: Kolhatkar
mesh_terms: D000280:Administration, Inhalation; D000293:Adolescent; D000328:Adult; D000336:Aerosols; D001249:Asthma / Q000188:drug therapy* / Q000503:physiopathology; D004334:Drug Administration Schedule; D005260:Female; D005541:Forced Expiratory Volume / Q000187:drug effects; D006801:Humans; D009241:Ipratropium / Q000008:administration & dosage / Q000627:therapeutic use*; D008297:Male; D010366:Peak Expiratory Flow Rate / Q000187:drug effects; D013997:Time Factors; D014797:Vital Capacity / Q000187:drug effects
chemical_list: D000336:Aerosols; D009241:Ipratropium