Absence of HLA-B8 and HLA-DR3 in Japanese patients with Sjögren's syndrome positive for anti-SSA(Ro).
Forty Japanese anti-SSA(Ro) positive patients with Sjögren's syndrome were typed for HLA-A, B, C, DR and DQ antigens. No patient had either HLA-B8 or HLA-DR3 which has been reportedly associated with the immune response to SSA(Ro) antigens in white and black patients. Our patients had higher frequencies of HLA-DRw8 and HLA-DRw52 than the control population.
Miyagawa
S
S
Department of Dermatology, Nara Medical University, Japan.
Dohi
K
K
Shima
H
H
Shirai
T
T
D000293:Adolescent; D000328:Adult; D000368:Aged; D001324:Autoantigens / Q000032:analysis*; D005260:Female; D015795:HLA-B8 Antigen / Q000032:analysis*; D015803:HLA-DR3 Antigen / Q000032:analysis*; D006801:Humans; D007564:Japan / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D020733:RNA, Small Cytoplasmic; D012261:Ribonucleoproteins / Q000032:analysis*; D012859:Sjogren's Syndrome / Q000453:epidemiology / Q000276:immunology*; D000099207:SS-A Antigen
D001324:Autoantigens; D015795:HLA-B8 Antigen; D015803:HLA-DR3 Antigen; D020733:RNA, Small Cytoplasmic; D012261:Ribonucleoproteins; D000099207:SS-A Antigen; C116006:RO60 protein, human