Thrombolytic properties in a rabbit jugular vein thrombosis model of a tissue-type plasminogen activator mutant lacking the growth factor- and kringle 1-domains.
Emeis
J J
JJ
Gaubius Laboratory, IVVO-TNO, Leiden, The Netherlands.
Verheijen
J H
JH
D000818:Animals; D005342:Fibrinolysis / Q000187:drug effects*; D007262:Infusions, Intravenous; D007275:Injections, Intravenous; D007601:Jugular Veins; D008657:Metabolic Clearance Rate; D011817:Rabbits; D011994:Recombinant Proteins / Q000008:administration & dosage / Q000493:pharmacokinetics / Q000627:therapeutic use*; D013927:Thrombosis / Q000188:drug therapy*; D010959:Tissue Plasminogen Activator / Q000008:administration & dosage / Q000493:pharmacokinetics / Q000627:therapeutic use*
D011994:Recombinant Proteins; D010959:Tissue Plasminogen Activator