title: [Complex studies of virology, microbiology, biochemistry and epidemiology in the adults of a semi-closed community vaccinated against influenza with the inactivated NIVGRIP vaccine intranasally].
abstract: A study was conducted on the specific and non specific immunomodulator effects of the inactivated vaccine NIVGRIP. The results revealed the seroconversion of HAI antibodies against influenza and mumps viruses and the reduction of viral and microbial flora of the pharynx. The kinetics of some proteins specific to the acute stage (siderophiline antitrypsin, microglobulin, complement C1q and C2 factors, C reactive protein and fibronectin) was also investigated and significant quantitative modifications were noticed in vaccinated subjects. The mean illness duration (acute respiratory disease) was three times as short in vaccinated subjects as in controls.
authors.affiliation: Institut de Virologie Stefan S. Nicolau, Bucarest, Roumanie.
authors.forename: N
authors.initials: N
authors.lastname: Steiner
authors.forename: I
authors.initials: I
authors.lastname: Ionită
authors.forename: C N
authors.initials: CN
authors.lastname: Zaharia
authors.forename: A
authors.initials: A
authors.lastname: Petrescu
authors.forename: I
authors.initials: I
authors.lastname: Ciocîrlie
authors.forename: D
authors.initials: D
authors.lastname: Stafie
authors.forename: A
authors.initials: A
authors.lastname: Dicu
authors.forename: A
authors.initials: A
authors.lastname: Stanciu
authors.forename: G
authors.initials: G
authors.lastname: Muşat
mesh_terms: D000209:Acute-Phase Proteins / Q000032:analysis; D000281:Administration, Intranasal; D000328:Adult; D000914:Antibodies, Viral / Q000097:blood; D016009:Chi-Square Distribution; D006801:Humans; D009980:Influenza A virus / Q000276:immunology; D007252:Influenza Vaccines / Q000008:administration & dosage*; D007251:Influenza, Human / Q000097:blood / Q000453:epidemiology / Q000382:microbiology* / Q000517:prevention & control; D009109:Mumps virus / Q000276:immunology; D010614:Pharynx / Q000382:microbiology; D012383:Romania / Q000453:epidemiology; D015164:Vaccines, Inactivated / Q000008:administration & dosage
chemical_list: D000209:Acute-Phase Proteins; D000914:Antibodies, Viral; D007252:Influenza Vaccines; D015164:Vaccines, Inactivated
vernacular_title: Etudes complexes de virologie, microbiologie, biochimie et épidémiologie sur des adultes d'une collectivité semi-fermée, vaccinés contre la grippe avee le vaccin inactivé NIVGRIP par voie intranasale.