Indomethacin treatment in children with daytime frequency of micturition.
Thirty children with daytime urinary frequency (DUFC) were randomly divided into two groups. The first group was given oral indomethacin, 1 mg/kg per dose, three times a day for 7 days. The frequency of urination fell from 26.3 +/- 2.3 to 11.7 +/- 2.8 at the end of the treatment period. The second group was treated with oral chloramphenicol, 30 mg/kg per day, in four divided doses for 7 days. Their urinary frequency did not change. They were then treated with a 1-week course of indomethacin and responded in a similar manner to group 1 patients. The use of indomethacin was accompanied by significant increases in plasma carbon dioxide-combining power, urine osmolality and urine pH; urine sodium and potassium levels decreased. These results show that a short course of indomethacin, in low dose, improves DUFC. We propose that it acts by inhibiting prostaglandin synthesis which modifies tubular function and increases urinary pH.
Luo
X Z
XZ
Department of Paediatrics, Shanghai Pudong Central Hospital, Peoples Republic of China.
D002245:Carbon Dioxide / Q000097:blood; D002648:Child; D002675:Child, Preschool; D002940:Circadian Rhythm / Q000502:physiology; D004305:Dose-Response Relationship, Drug; D006801:Humans; D006863:Hydrogen-Ion Concentration; D007213:Indomethacin / Q000627:therapeutic use*; D011188:Potassium / Q000652:urine; D012964:Sodium / Q000652:urine; D014555:Urination Disorders / Q000188:drug therapy* / Q000503:physiopathology
D002245:Carbon Dioxide; D012964:Sodium; D011188:Potassium; D007213:Indomethacin