Antagonism of the lethal effects of cyanide with resealed erythrocytes containing rhodanese and thiosulfate.
A new concept has been presented for the antagonism of cyanide and possibly other chemical toxicants. Until now, only a half dozen truly specific "antidotes" were known. There are many other "antidotes" which merely prevent the absorption or enhance the elimination of a toxic compound rather than specifically destroying the substance to prevent its toxic effect. This new approach has considerable conceptual significance in toxicology, as it suggests the encapsulating other enzymes to degrade various other chemical toxicants. There are many chemical toxicants for which there are no specific antidotes, and the conceptual approach of employing erythrocyte-encapsulated enzyme provides an innovative, specific approach to antagonize the toxic and lethal effects of these chemicals.
Way
J L
JL
Department of Medical Pharmacology & Toxicology, Texas A & M University, College of Medicine, College Station.
Cannon
E P
EP
Leung
P
P
Hawkins-Zitzer
A
A
Pei
L
L
Petrikovics
I
I
D000818:Animals; D004337:Drug Carriers; D004910:Erythrocyte Membrane; D007928:Lethal Dose 50; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D011190:Potassium Cyanide / Q000037:antagonists & inhibitors*; D012977:Sodium Nitrite / Q000008:administration & dosage*; D013884:Thiosulfate Sulfurtransferase / Q000008:administration & dosage*; D013885:Thiosulfates / Q000008:administration & dosage*
D004337:Drug Carriers; D013885:Thiosulfates; D013884:Thiosulfate Sulfurtransferase; C017717:sodium thiosulfate; D012977:Sodium Nitrite; D011190:Potassium Cyanide