[Estradiol-17beta, sex steroid-binding globulin and the cellular and humoral immunity indices in young women with breast cancer].
Blood serum levels of sex steroid-binding globulin (SSBG), free and SSBG- and albumin-binding fractions of estradiol-17 beta as well as some indexes of cellular and humoral immunity were compared in 25 young female patients with stage 1-3 breast cancer and controls. No significant difference in SSBG and free estradiol-17 beta fraction as well as free estrogen index was established between patients and controls. In the patient group, a direct correlation was established between free estradiol-17 beta fraction level and that of mature T-cells expressing CD3 antigen and between SSBG level, on the one hand, and total level of T-cells (CD7 antigen) and that of T-suppressors (CD8 antigen-containing cytotoxic lymphocytes), on the other. An inverse correlation was established in the same group between SSBG level and that of B-cell markers expressing CD3 and 7 antigens and IgM mu-chain. In the follicular and lutein phases of the menstrual cycle, a difference in the degree of correlation between total estradiol-17 beta level and immunologic indexes was established between breast cancer patients and controls.
Chobanian
N S
NS
Kushlinskiĭ
N E
NE
Bassalyk
L S
LS
Kuz'mina
Z V
ZV
Savel'eva
E V
EV
Baryshnikov
A Iu
AIu
Kadagidze
Z G
ZG
D000328:Adult; D000917:Antibody Formation; D015703:Antigens, CD / Q000097:blood; D001402:B-Lymphocytes / Q000276:immunology; D014408:Biomarkers, Tumor / Q000097:blood; D001943:Breast Neoplasms / Q000097:blood* / Q000276:immunology; D004958:Estradiol / Q000097:blood*; D005260:Female; D006801:Humans; D007111:Immunity, Cellular; D008597:Menstrual Cycle / Q000276:immunology; D011485:Protein Binding; D012709:Serum Albumin / Q000032:analysis; D012738:Sex Hormone-Binding Globulin / Q000032:analysis*; D013601:T-Lymphocytes / Q000276:immunology
D015703:Antigens, CD; D014408:Biomarkers, Tumor; D012709:Serum Albumin; D012738:Sex Hormone-Binding Globulin; D004958:Estradiol
Estradiol-17beta, polovye steroidy sviazyvaiushchiĭ globulin i nekotorye pokazateli kletochnogo i gumoral'nogo immuniteta u molodykh zhenshchin, bol'nykh rakom molochnoĭ zhelezy.