title: Spinal cord claudication from amyloid deposition.
abstract: We describe the clinical course of an 81-year-old woman who was evaluated for worsening symptomatology of spinal cord claudication. Diagnostic studies revealed mild lumbar canal stenosis at L3-4, severe stenosis at L4-5 with a myelogram-CT scan demonstrating a complete block at this level mainly a result of a hypertrophied ligamentum flavum. At surgery, the ligamentum was found to be thickened and to be causing severe compression of the dural tube. Pathologic studies of the excised ligamentum flavum revealed extensive amyloid protein deposition. The amyloid was not further classified with further medical evaluation and followup failing to identify any conditions associated with local or systemic amyloidosis.
authors.affiliation: Department of Rheumatology and Molecular Medicine, Hospital for Joint Diseases, New York, NY 10003.
authors.forename: S
authors.initials: S
authors.lastname: Honig
authors.forename: R
authors.initials: R
authors.lastname: Murali
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000682:Amyloid / Q000032:analysis* / Q000378:metabolism; D000686:Amyloidosis / Q000150:complications* / Q000378:metabolism; D005260:Female; D006801:Humans; D013116:Spinal Cord / Q000737:chemistry / Q000000981:diagnostic imaging / Q000378:metabolism; D013118:Spinal Cord Diseases / Q000209:etiology* / Q000378:metabolism / Q000473:pathology; D013130:Spinal Stenosis / Q000175:diagnosis / Q000000981:diagnostic imaging / Q000209:etiology; D014057:Tomography, X-Ray Computed
chemical_list: D000682:Amyloid