title: A comparative study of bronchodilator actions of ipratropium bromide (atrovent) & salbutamol (ventolin) on exercise induced bronchial asthma.
abstract: The bronchodilator actions of salbutamol and ipratropium bromide were compared in 30 established cases of bronchial asthma, before and after exercise. It was noticed that after exercise (brisk walk for 3 min.) the PFT values of FVC, PEFR and FEV-1, decreased remarkably from the basal values, the mean fall of 17.91%, 10.68% & 14.8% respectively was noticed. Salbutamol showed improvement in FVC, PEFR, FEV-1, of 20.86%, 15.96% & 17.98% respectively from basal values, while Ipratropium bromide showed improvement by 18.31%, 13.01% & 20.90% respectively. It was also noted that salbutamol is a better drug amongst smokers, patients with family history of bronchial asthma, and in younger age groups. Ipratropium bromide was better in elderly patients (> 40 yrs.) and in those with eosinophillia.
authors.affiliation: Dept of Medicine, JLN Medical College & Hospital, Ajmer.
authors.forename: J P
authors.initials: JP
authors.lastname: Singh
authors.forename: R
authors.initials: R
authors.lastname: Singh
authors.forename: R C
authors.initials: RC
authors.lastname: Gupta
authors.forename: B
authors.initials: B
authors.lastname: Bharadwaja
mesh_terms: D000328:Adult; D000367:Age Factors; D000420:Albuterol / Q000494:pharmacology*; D001250:Asthma, Exercise-Induced / Q000188:drug therapy* / Q000503:physiopathology; D005260:Female; D005541:Forced Expiratory Volume / Q000187:drug effects / Q000502:physiology; D006801:Humans; D009241:Ipratropium / Q000494:pharmacology*; D008297:Male; D010366:Peak Expiratory Flow Rate / Q000187:drug effects / Q000502:physiology; D014797:Vital Capacity / Q000187:drug effects / Q000502:physiology
chemical_list: D009241:Ipratropium; D000420:Albuterol