title: [The role of electrochemical techniques in the understanding of the mechanism of drug actions. Example of an anti-Bilharzia agent].
abstract: In order to gain an interpretation of the schistosomicidal effect of 4-methyl-5-(2-pyrazinyl)-1,2-dithiole-3-thione (Oltipraz), chemical, electrochemical and enzymatic hypotheses are discussed from a pharmacological standpoint. The enzymatic hypothesis is in good agreement with experimental results which ascertain that Oltipraz behaves as a prodrug.
authors.affiliation: Laboratoire de Chimie Analytique, UER de Sciences Pharmaceutiques, Paris.
authors.forename: M B
authors.initials: MB
authors.lastname: Fleury
mesh_terms: D004563:Electrochemistry; D005980:Glutathione Reductase / Q000378:metabolism; D066298:In Vitro Techniques; D011719:Pyrazines / Q000378:metabolism / Q000494:pharmacology*; D012556:Schistosomicides / Q000378:metabolism / Q000494:pharmacology*; D013871:Thiones; D013876:Thiophenes
chemical_list: D011719:Pyrazines; D012556:Schistosomicides; D013871:Thiones; D013876:Thiophenes; C026209:oltipraz; D005980:Glutathione Reductase
vernacular_title: Apport des techniques électrochimiques à la compréhension du mécanisme d'action d'un médicament. Exemple d'un antibilharzien.