title: [The pharmacokinetics and pharmacodynamics of the prolonged-action beta-adrenoblocker nadolol at rest after a single administration to hypertension patients].
abstract: The pharmacokinetics and pharmacodynamics of nadolol given in a single dose of 80 mg to 17 patients with mild hypertension were studied by echocardiography at rest. The major pharmacokinetic parameters for nadolol did not differ greatly from those reported in the literature and obtained from volunteers. No correlation was found between endogenous creatine clearance and renal nadolol clearance. How the hemodynamic effect developed and whether it was related to blood nadolol concentrations in time after single administration were followed up and discussed. There was a significant decline in blood pressure 2 hours after the drug. There was a clock-wise hysteresis in the relationship between the changes in cardiac output and nadolol levels. Changes in blood pressure were shown to significantly correlate with those in cardiac output.
authors.forename: A V
authors.initials: AV
authors.lastname: Poteshnykh
authors.forename: N P
authors.initials: NP
authors.lastname: Filatova
authors.forename: V I
authors.initials: VI
authors.lastname: Metelitsa
authors.forename: V K
authors.initials: VK
authors.lastname: Piotrovskiĭ
authors.forename: N V
authors.initials: NV
authors.lastname: Malysheva
authors.forename: A Iu
authors.initials: AIu
authors.lastname: Ignat'ev
mesh_terms: D000328:Adult; D003692:Delayed-Action Preparations; D004341:Drug Evaluation; D004452:Echocardiography / Q000187:drug effects; D006439:Hemodynamics / Q000187:drug effects; D006801:Humans; D006973:Hypertension / Q000097:blood* / Q000000981:diagnostic imaging / Q000188:drug therapy / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D009248:Nadolol / Q000008:administration & dosage / Q000493:pharmacokinetics* / Q000494:pharmacology*; D013997:Time Factors
chemical_list: D003692:Delayed-Action Preparations; D009248:Nadolol
vernacular_title: Farmakokinetika i farmakodinamika beta-adrenoblokatora prolongirovannogo deĭstviia nadolola v pokoe posle odnokratnogo priema u bol'nykh gipertonicheskoĭ bolezn'iu.