[The central and peripheral components in the mechanism of action of urapidil].
Effects of two doses of urapidil (0.6 mg/kg and 1.2 mg/kg, i.v.) on the sympathetic nervous activity (renal nerve) and sensitivity of the chronotropic and sympathetic components of the baroreceptor reflex were studied in experiments on awake Wistar rats. Urapidil did not change significantly the baseline sympathetic nervous activity. The sensitivity of the sympathetic baroreceptor reflex tested by phenylephrine was significantly enhanced and that tested by nitroprusside was significantly inhibited by urapidil. The sensitivity of the heart rate baroreceptor reflex tested by phenylephrine remained unchanged whereas that tested by nitroprusside was significantly inhibited by urapidil. It is concluded that urapidil changes the sensitivity of the baroreceptor reflex via the central mechanism of action.
Maĭorov
D N
DN
Medvedev
O S
OS
D000818:Animals; D000959:Antihypertensive Agents / Q000494:pharmacology*; D001794:Blood Pressure / Q000187:drug effects; D004347:Drug Interactions; D004567:Electrodes, Implanted; D006339:Heart Rate / Q000187:drug effects; D008297:Male; D009599:Nitroprusside / Q000494:pharmacology; D010656:Phenylephrine / Q000494:pharmacology; D010879:Piperazines / Q000494:pharmacology*; D011311:Pressoreceptors / Q000187:drug effects; D051381:Rats; D017208:Rats, Wistar; D012018:Reflex / Q000187:drug effects; D013564:Sympathetic Nervous System / Q000187:drug effects*; D014851:Wakefulness / Q000187:drug effects
D000959:Antihypertensive Agents; D010879:Piperazines; D009599:Nitroprusside; D010656:Phenylephrine; C015568:urapidil
Tsentral'nyĭ i perifericheskiĭ komponenty v mekhanizme deĭstviia urapidila.