[The effect of a high external temperature on cellular immunity].
The study was made of spleen cells proliferative response to mitogens PHA, Con A or alloantigens in relation to hyperthermia effects. Acute hyperthermia (rectal temperature 42 degrees) enhanced lymphocyte function, proliferative responses to allo-antigens, PHA and Con A increased. Thermal shock was associated with suppression of the spleen cell response. Mice suffering from hyperthermia for 20 min (43-44 degrees) daily during 10, 20 and 30 days showed suppressed T-cell immune response. Normal splenocyte proliferation recovered 40 days after hyperthermia induction.
Solov'ev
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D000208:Acute Disease; D000818:Animals; D006359:Heat Exhaustion / Q000276:immunology; D006358:Hot Temperature; D007111:Immunity, Cellular; D051379:Mice; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D013154:Spleen / Q000166:cytology / Q000276:immunology; D013696:Temperature; D013997:Time Factors
Vliianie vysokoĭ vneshneĭ temperatury na sostoianie kletochnogo immuniteta.