Interaction between Ukrain and aminophenazone in analgesic tests in rodents.
The effect of Ukrain on the analgesic activity of aminophenazone was studied in mice and rats. Antinociceptive action induced by aminophenazone in doses of 50 or 100 mg/kg intraperitoneally (i.p.) was determined by using the writhing syndrome, hot-plate tests and tail-flick latency. The action of aminophenazone was significantly enhanced by Ukrain in the writhing syndrome test and in the tail-flick test. Antinociceptive action of aminophenazone was decreased by Ukrain in the hot-plate test in mice. These results suggest that Ukrain, given simultaneously with aminophenazone, changes susceptibility of animals to nociceptive reaction in the tests performed.
Kleinrok
Z
Z
Department of Pharmacology, Medical Academy, Lublin, Poland.
Jagiełło-Wójtowicz
E
E
Nowicky
J W
JW
Chodkowska
A
A
Feldo
M
M
D000085:Acetates; D019342:Acetic Acid; D000470:Alkaloids / Q000008:administration & dosage / Q000494:pharmacology*; D000632:Aminopyrine / Q000008:administration & dosage / Q000494:pharmacology*; D000700:Analgesics / Q000008:administration & dosage / Q000494:pharmacology*; D000818:Animals; D001600:Berberine Alkaloids; D004357:Drug Synergism; D007274:Injections, Intraperitoneal; D008297:Male; D051379:Mice; D010146:Pain / Q000139:chemically induced; D010147:Pain Measurement / Q000187:drug effects; D010617:Phenanthridines; D051381:Rats; D017208:Rats, Wistar; D011930:Reaction Time / Q000187:drug effects
D000085:Acetates; D000470:Alkaloids; D000700:Analgesics; D001600:Berberine Alkaloids; D010617:Phenanthridines; D000632:Aminopyrine; C060921:ukrain; D019342:Acetic Acid