title: Lymphocyte responses to food antigens in food sensitive patients with allergic tension-fatigue syndrome.
abstract: Scores of radioallergosorbent test (RAST) for cow's milk or buckwheat flour and proliferative responses of peripheral blood mononuclear cells (PBMCs) to bovine serum albumin and beta-lactoglobulin or buckwheat flour were measured in cow's milk or buckwheat flour sensitive patients with allergic tension-fatigue syndrome. In all 3 cow's milk sensitive patients with allergic tension-fatigue syndrome, RAST scores for cow's milk were negative or slightly positive, but PBMCs well responded to bovine serum albumin and beta-lactoglobulin, but not to ovalbumin. In a buckwheat flour sensitive patient with allergic tension-fatigue syndrome, RAST scores for buckwheat flour were negative, but PBMCs well responded to buckwheat flour, but not to ovalbumin, bovine serum albumin and beta-lactoglobulin. Conversely, in cow's milk or buckwheat flour sensitive patients with immediate allergic symptoms, RAST scores for offending foods were positive although PBMCs did not respond to offending food antigens. These results suggest that proliferative responses of PBMCs to food antigens are very useful for detection of offending foods in allergic tension-fatigue syndrome.
authors.affiliation: Department of Pediatrics, Gifu University School of Medicine, Japan.
authors.forename: N
authors.initials: N
authors.lastname: Kondo
authors.forename: S
authors.initials: S
authors.lastname: Shinoda
authors.forename: H
authors.initials: H
authors.lastname: Agata
authors.forename: T
authors.initials: T
authors.lastname: Nishida
authors.forename: Y
authors.initials: Y
authors.lastname: Miwa
authors.forename: H
authors.initials: H
authors.lastname: Fujii
authors.forename: T
authors.initials: T
authors.lastname: Orii
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000418:Albumins / Q000494:pharmacology; D000818:Animals; D000941:Antigens / Q000276:immunology*; D001007:Anxiety; D002417:Cattle; D002648:Child; D004311:Double-Blind Method; D005221:Fatigue / Q000276:immunology; D005260:Female; D005433:Flour / Q000009:adverse effects; D005512:Food Hypersensitivity / Q000276:immunology*; D006801:Humans; D007073:Immunoglobulin E / Q000032:analysis; D007782:Lactoglobulins / Q000494:pharmacology; D007963:Leukocytes, Mononuclear / Q000276:immunology; D008213:Lymphocyte Activation / Q000276:immunology*; D008297:Male; D008875:Middle Aged; D016269:Milk Hypersensitivity / Q000276:immunology; D011852:Radioallergosorbent Test; D013577:Syndrome
chemical_list: D000418:Albumins; D000941:Antigens; D007782:Lactoglobulins; D007073:Immunoglobulin E