title: Bacteraemia in severely malnourished children.
abstract: During a 2-year period, 792 severely malnourished children (kwashiorkor, marasmus and marasmic kwashiorkor) were hospitalized (14.8% of all admissions). Community-acquired bacteraemia was recorded in 7.7% and nosocomial bacteraemia in 2.2% of malnourished children. The relative risk for bacteraemia on admission was 1.6 (95% confidence interval [CI] 1.3-1.9) and 2.0 for nosocomial bacteraemia (95% CI 1.4-3.0) in malnourished children as compared with well nourished children. Bacteraemia was 3.5 times more common in children with kwashiorkor than in marasmic children. Gram-negative enteric aerobes were isolated 2.6 times more frequently from malnourished than from well nourished children. The relative risk of death in malnourished children with bacteraemia was 2.5 times that of malnourished children without bacteraemia. Thirty-six per cent of deaths in children with kwashiorkor were related to bacteraemia. This study emphasizes the increased risk of bacteraemia in malnourished children, particularly those with kwashiorkor, and the impact on mortality.
authors.affiliation: Department of Paediatrics, Baragwanath Hospital, Johannesburg, South Africa.
authors.forename: I R
authors.initials: IR
authors.lastname: Friedland
mesh_terms: D016470:Bacteremia / Q000453:epidemiology* / Q000209:etiology / Q000382:microbiology; D002175:Candida / Q000302:isolation & purification; D016022:Case-Control Studies; D002648:Child; D002675:Child, Preschool; D003428:Cross Infection / Q000453:epidemiology / Q000382:microbiology; D004352:Drug Resistance, Microbial; D004755:Enterobacteriaceae / Q000302:isolation & purification; D006801:Humans; D007223:Infant; D007732:Kwashiorkor / Q000150:complications*; D011446:Prospective Studies; D011502:Protein-Energy Malnutrition / Q000150:complications*; D012307:Risk Factors