The effect of hemorrhagic shock on intestinal amino acid absorption in vivo.
Hemorrhagic shock causes a disproportionate decrease in portal blood flow which may adversely affect the barrier and absorptive functions of the intestine. The absorptive capacity of the small intestine was studied during shock induced by mild and severe hemorrhage in the rat by measurement of the uptake of a radiolabelled amino acid analog (aminoisobutyric acid: AIB). Hemorrhage resulted in a significant reduction in systemic blood pressure, portal blood flow, and the absorption of AIB from the small intestine. Resuscitation restored both blood pressure and portal blood flow. But a significant reduction in absorption of AIB persisted. This suggests that hemorrhage results in an inhibition of amino acid intestinal active transport which is not dependent on the mesenteric circulation. The reduced intestinal absorptive function has important implications for the route of administration of nutrition following hemorrhage and trauma.
Sodeyama
M
M
Department of Surgery, Sinai Hospital, Baltimore, MD 21215.
Kirk
S J
SJ
Regan
M C
MC
Barbul
A
A
D000621:Aminoisobutyric Acids / Q000493:pharmacokinetics*; D000818:Animals; D001794:Blood Pressure; D007408:Intestinal Absorption; D007421:Intestine, Small / Q000378:metabolism*; D008297:Male; D011168:Portal System / Q000502:physiology; D051381:Rats; D017207:Rats, Sprague-Dawley; D012771:Shock, Hemorrhagic / Q000503:physiopathology*
D000621:Aminoisobutyric Acids