[The role of endogenous opioids in modulation of immunosuppression in fish].
We have previously shown that social confrontation between aggressive fish (e.g., Tilapia) produces a suppression of several immunological parameters--nonspecific cytotoxicity and mitogen-stimulated proliferation in pronephric lymphocytes--in the subordinate fish. By using the opioid antagonist, naltrexone, we now demonstrate indirectly that this immunosuppression is in part mediated by the endogenous opioid system. Evidence is presented that naltrexone-mediated reversal of immunosuppression may be limited to the populations of the cytotoxic and T-cell lineages. The proliferative response to lipopolysaccharide is unaffected by naltrexone. Our data also demonstrate that serum from subordinate (immunosuppressed) fish is immunosuppressive in normal fish: an effect that can be reversed by naltrexone. These results support a link between the neuroendocrine and immune systems in these animals.
Faisal
M
M
Chiappelli
F
F
Ahmed
I I
II
Cooper
E L
EL
Weiner
H
H
D000374:Aggression / Q000187:drug effects / Q000502:physiology; D000818:Animals; D001143:Arousal / Q000187:drug effects / Q000502:physiology; D003602:Cytotoxicity, Immunologic / Q000187:drug effects / Q000502:physiology; D004291:Dominance-Subordination; D004723:Endorphins / Q000502:physiology*; D007108:Immune Tolerance / Q000187:drug effects / Q000502:physiology*; D008213:Lymphocyte Activation / Q000187:drug effects / Q000502:physiology; D009271:Naltrexone / Q000494:pharmacology; D017210:Tilapia
D004723:Endorphins; D009271:Naltrexone
Die Rolle endogener Opioide in der Modulation der Immunsuppression bei Fischen.