title: Treatment of aggressive cytomegalovirus retinitis with ganciclovir in combination with foscarnet in a child infected with human immunodeficiency virus.
abstract: Ganciclovir and foscarnet are both effective for cytomegalovirus retinitis in patients with acquired immunodeficiency syndrome, but the benefits of either agent given alone are limited. A child infected with human immunodeficiency virus who had cytomegalovirus retinitis that progressed despite treatment with either agent alone received the combination of ganciclovir and foscarnet. This treatment resulted in a sustained clinical response.
authors.affiliation: Pediatric Branch, National Cancer Institute, National Institutes for Health, Bethesda, MD 20892.
authors.forename: K M
authors.initials: KM
authors.lastname: Butler
authors.forename: M D
authors.initials: MD
authors.lastname: De Smet
authors.forename: R N
authors.initials: RN
authors.lastname: Husson
authors.forename: B
authors.initials: B
authors.lastname: Mueller
authors.forename: K
authors.initials: K
authors.lastname: Manjunath
authors.forename: K
authors.initials: K
authors.lastname: Montrella
authors.forename: G
authors.initials: G
authors.lastname: Lovato
authors.forename: P
authors.initials: P
authors.lastname: Jarosinski
authors.forename: R B
authors.initials: RB
authors.lastname: Nussenblatt
authors.forename: P A
authors.initials: PA
authors.lastname: Pizzo
mesh_terms: D000998:Antiviral Agents / Q000008:administration & dosage*; D002675:Child, Preschool; D003586:Cytomegalovirus Infections / Q000150:complications / Q000188:drug therapy*; D004359:Drug Therapy, Combination; D005260:Female; D017245:Foscarnet; D015774:Ganciclovir / Q000008:administration & dosage*; D015658:HIV Infections / Q000150:complications*; D006801:Humans; D010746:Phosphonoacetic Acid / Q000008:administration & dosage / Q000031:analogs & derivatives*; D012173:Retinitis / Q000150:complications / Q000188:drug therapy*
chemical_list: D000998:Antiviral Agents; D017245:Foscarnet; D010746:Phosphonoacetic Acid; D015774:Ganciclovir