[Embryotoxic effects of N-nitrosodimethylamine in mice].
N-nitrosodimethylamine was administered intraperitoneally in the dose of 5.5 mg.kg-1 body eight to pregnant ICR mice on days 3, 5, 9, 12 of gestation. The administered dose caused a statistically significant increase of resorptions at each stage of pregnancy studied. The pregnancy rate of females treated at any stage of organogenesis studied was reduced, most markedly in mice treated on day 12 of gestation. No malformations or skeletal anomalies were observed.
Siviková
K
K
Oddelenie veterinárnej genetiky VSV, Kosiciach, CSFR.
Dianovský
J
J
D000014:Abnormalities, Drug-Induced / Q000209:etiology; D000818:Animals; D004128:Dimethylnitrosamine / Q000633:toxicity*; D005260:Female; D005327:Fetal Resorption / Q000139:chemically induced; D005333:Fetus / Q000187:drug effects*; D051379:Mice; D008813:Mice, Inbred ICR; D011247:Pregnancy
D004128:Dimethylnitrosamine
Embryotoxický úcinok N-nitrózodimetylamínu u mysí.