title: Neonatal complications and risk of intraventricular-periventricular hemorrhage.
abstract: We have prospectively studied 117 premature infants < or = 1500 gm (VLBW) to assess the relationship between maternal, obstetric, fetal and newborn complications and the grade of periventricular-intraventricular hemorrhage (PVH-IVH). PVH-IVH was documented by cranial ultrasonography in 41% of surviving neonates. 83% of infants with PVH-IVH grade I-II survived as compared to the 39% of infants with PVH-IVH grade III-IV (p < .001). Maternal and obstetric complications were not associated with PVH-IVH (NS). Newborn respiratory complications (p < .004) and major infections (p < .02) are independent variables associated with PVH-IVH. Immaturity at delivery, metabolic acidosis, respiratory distress syndrome and recurrent apnea are important mechanisms of cerebral injury contributing to severity of PVH-IVH.
authors.affiliation: Department of Obstetrics & Gynecology, Parma, University School of Medicine.
authors.forename: B
authors.initials: B
authors.lastname: Ferrari
authors.forename: G
authors.initials: G
authors.lastname: Tonni
authors.forename: R
authors.initials: R
authors.lastname: Luzietti
authors.forename: G
authors.initials: G
authors.lastname: Ciarlini
authors.forename: E
authors.initials: E
authors.lastname: Vadora
authors.forename: A
authors.initials: A
authors.lastname: Merialdi
mesh_terms: D000136:Acid-Base Equilibrium; D001049:Apnea / Q000150:complications; D001724:Birth Weight; D002543:Cerebral Hemorrhage / Q000453:epidemiology* / Q000209:etiology / Q000401:mortality; D005260:Female; D005865:Gestational Age; D006801:Humans; D015994:Incidence; D007230:Infant, Low Birth Weight; D007231:Infant, Newborn; D007235:Infant, Premature, Diseases / Q000453:epidemiology* / Q000209:etiology / Q000401:mortality; D007239:Infections / Q000150:complications; D007744:Obstetric Labor Complications; D010102:Oxygen Inhalation Therapy / Q000009:adverse effects; D011247:Pregnancy; D011248:Pregnancy Complications; D011446:Prospective Studies; D012044:Regression Analysis; D012127:Respiratory Distress Syndrome, Newborn / Q000150:complications; D012307:Risk Factors; D012640:Seizures / Q000150:complications