Human papillomavirus type 6a DNA in the lung carcinoma of a patient with recurrent laryngeal papillomatosis is characterized by a partial duplication.
Transcriptionally active human papillomavirus type 6a (HPV-6a) DNA was detected in a lung carcinoma of a patient with recurrent laryngeal papillomatosis. The carcinoma contained episomal HPV-6a genomes that had a duplication of the upstream regulatory region, the late region and a portion of the early region. HPV-6a genomes found in benign laryngeal papillomas from the same patient did not contain this duplication. A role for the mutant molecules in the pathogenesis of the malignancy is suggested.
DiLorenzo
T P
TP
Department of Otolaryngology and Communicative Disorders, Long Island Jewish Medical Center, New Hyde Park, New York 11042.
Tamsen
A
A
Abramson
A L
AL
Steinberg
B M
BM
D000328:Adult; D015152:Blotting, Northern; D015139:Blotting, Southern; D002294:Carcinoma, Squamous Cell / Q000382:microbiology*; D004262:DNA Restriction Enzymes; D004279:DNA, Viral / Q000032:analysis / Q000235:genetics; D006801:Humans; D007822:Laryngeal Neoplasms / Q000382:microbiology*; D008175:Lung Neoplasms / Q000382:microbiology*; D008297:Male; D005810:Multigene Family; D009154:Mutation; D009364:Neoplasm Recurrence, Local / Q000382:microbiology; D010212:Papilloma / Q000382:microbiology*; D027383:Papillomaviridae / Q000235:genetics*; D012367:RNA, Viral / Q000032:analysis; D015183:Restriction Mapping; D014158:Transcription, Genetic
D004279:DNA, Viral; D012367:RNA, Viral; D004262:DNA Restriction Enzymes