Cage allocation designs for rodent carcinogenicity experiments.
Cage allocation designs for rodent carcinogenicity experiments are discussed and presented with the goal of avoiding dosage group biases related to cage location. Considerations in selecting a cage design are first discussed in general terms. Specific designs are presented for use in experiments involving three, four, and five dose groups and with one, four, and five rodents per cage. Priorities for balancing treatment groups include horizontal position on shelf and shelf of rack, nearest neighbor balance, and male-female balance. It is proposed that these balance criteria be considered together with practical issues, such as the ability to accurately conform to a design and to determine a sensible and efficient design for each experiment.
Herzberg
A M
AM
Queens University, Kingston, Ontario, Canada.
Lagakos
S W
SW
D000818:Animals; D000830:Animals, Laboratory; D015197:Carcinogenicity Tests; D006799:Housing, Animal; D051379:Mice; D051381:Rats; D012107:Research Design