title: Sympathoinhibition and hypotension in carotid sinus hypersensitivity.
abstract: Carotid sinus reflex hypersensitivity is a known cause of syncope in humans. The condition is characterized by cardioinhibition and vasodepression, each to varying degrees. The extent and importance of sympathoinhibition has not been determined in patients with carotid sinus hypersensitivity. This study reports on the extent of sympathoinhibition measured directly directly during carotid massage with and without atrioventricular sequential pacing, in a patient with symptomatic carotid sinus reflex hypersensitivity. Carotid massage elicited asystole, hypotension and complete inhibition of muscle sympathetic nerve activity. Carotid massage during atrioventricular pacing produced similar sympathoinhibition, but with minimal hypotension. Therefore, sympathoinhibition did not contribute importantly to the hypotension during carotid massage in the supine position in this patient. Further investigations are required to elucidate the relation of sympathoinhibition to hypotension in patients with carotid sinus hypersensitivity in the upright position.
authors.affiliation: Department of Medicine, Hunter Holmes McGuire Department of Veterans Affairs Medical Center, Richmond 23249.
authors.forename: M L
authors.initials: ML
authors.lastname: Smith
authors.forename: K A
authors.initials: KA
authors.lastname: Ellenbogen
authors.forename: D L
authors.initials: DL
authors.lastname: Eckberg
mesh_terms: D002346:Carotid Sinus / Q000503:physiopathology*; D004244:Dizziness / Q000209:etiology*; D006801:Humans; D007024:Hypotension, Orthostatic / Q000209:etiology*; D008297:Male; D008875:Middle Aged; D009433:Neural Inhibition; D011311:Pressoreceptors; D013564:Sympathetic Nervous System / Q000503:physiopathology*; D013575:Syncope / Q000209:etiology*