title: [Lipid and lipoprotein profile in psoriasis].
abstract: Psoriasis is a common relapsing dermatosis characterized by an increased epidermal cell proliferation. In this work we studied the lipid and lipoprotein pattern in 17 patients affected by long-standing psoriasis and in 20 normal controls. Total cholesterol, triglyceride, HDL-cholesterol and Apolipoprotein AI and B levels were measured; VLDL, LDL and HDL chemical composition was assessed by preparative ultracentrifugation. Plasma lipid and lipoprotein levels were significantly lower in the patient group; chemical analysis of the main lipoprotein classes showed compositional abnormalities consistent with an accelerated turnover of these particles. We believe that epidermal cell proliferation can play a role in determining these changes.
authors.affiliation: Cattedra di Biochimica Clinica, Facoltà di Medicina, Università degli Studi di Sassari.
authors.forename: L
authors.initials: L
authors.lastname: Deiana
authors.forename: G M
authors.initials: GM
authors.lastname: Pes
authors.forename: C
authors.initials: C
authors.lastname: Carru
authors.forename: M
authors.initials: M
authors.lastname: Tidore
authors.forename: G M
authors.initials: GM
authors.lastname: Cherchi
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D005260:Female; D006801:Humans; D015603:Keratinocytes / Q000378:metabolism; D008055:Lipids / Q000097:blood*; D008074:Lipoproteins / Q000097:blood*; D008297:Male; D008875:Middle Aged; D011565:Psoriasis / Q000097:blood*
chemical_list: D008055:Lipids; D008074:Lipoproteins
vernacular_title: Assetto lipidico e lipoproteico nella psoriasi.