IgE levels in faecal extracts of patients with food allergy.
IgE levels in faecal extracts (Copro-IgE levels) were investigated in food allergy (FA) patients before and after the challenge test administration of food allergens. IgE levels were measured by time-resolved fluoroimmunometric assay. In addition, the effects of administration of oral sodium cromoglycate (SCG) on the Copro-IgE levels were studied. Copro-IgE levels in patients with FA, who were placed on an elimination diet, did not differ from those of healthy children. After a challenge test immediate symptoms of urticaria and wheezing were observed in all FA patients. Copro-IgE levels in each patient increased markedly within 24 h of the challenge test. Moreover, FA patients treated orally with SCG showed neither the increase in Copro-IgE levels nor any remarkable symptoms after the challenge. Our results suggest that the increased Copro-IgE levels may be a specific consequence of the local immune response to food allergen stimulation in the gut mucosa.
Sasai
K
K
Department of Pediatrics, Juntendo University School of Medicine, Tokyo, Japan.
Furukawa
S
S
Sugawara
T
T
Kaneko
K
K
Baba
M
M
Yabuta
K
K
D000485:Allergens / Q000276:immunology; D002675:Child, Preschool; D004311:Double-Blind Method; D005243:Feces / Q000737:chemistry*; D005260:Female; D005512:Food Hypersensitivity / Q000188:drug therapy / Q000276:immunology*; D006801:Humans; D007071:Immunoglobulin A, Secretory / Q000032:analysis; D007073:Immunoglobulin E / Q000032:analysis*; D007223:Infant; D008297:Male; D015203:Reproducibility of Results
D000485:Allergens; D007071:Immunoglobulin A, Secretory; D007073:Immunoglobulin E