title: Expression of neuron-specific enolase immunoreactivity by cutaneous and extracutaneous Langerhans-cell histiocytoses ("X").
abstract: The immunohistochemical expression of Neuron-Specific Enolase (NSE) and of S100 protein was studied in 10 cases of cutaneous and 19 cases of extracutaneous Langerhans cell histiocytoses (LCH), including acute/proliferative forms (cutaneous Letterer-Siwe disease) and chronic/granulomatous forms (eosinophilic granuloma, Hand-Schüller-Christian disease). Of the LCH cases, 18 (62%) exhibited detectable NSE-immunoreactivity as compared to 82.8% for S100. NSE expression was found more frequently and intensely within acute (as compared to chronic) forms of LCH. This result lends further support to the cellular unicity of LCH, but also suggests some degree of heterogeneity among LCH cells. It can be speculated that NSE-expression is correlated with the proliferation/activation state of (abnormal) Langerhans cells.
authors.affiliation: Lab. of Dermatopathology/INSERM U346, Hôp. Ed. Herriot (Pav. R), Lyon, France.
authors.forename: M
authors.initials: M
authors.lastname: Roca-Miralles
authors.forename: J
authors.initials: J
authors.lastname: Kanitakis
authors.forename: F
authors.initials: F
authors.lastname: Béjui-Thivolet
authors.forename: D
authors.initials: D
authors.lastname: Schmitt
authors.forename: A
authors.initials: A
authors.lastname: Castels-Rodellas
authors.forename: J
authors.initials: J
authors.lastname: Thivolet
mesh_terms: D001847:Bone Diseases / Q000201:enzymology; D006644:Histiocytes / Q000201:enzymology; D006646:Histiocytosis, Langerhans-Cell / Q000201:enzymology*; D015616:Histiocytosis, Non-Langerhans-Cell / Q000201:enzymology; D006801:Humans; D007150:Immunohistochemistry; D008171:Lung Diseases / Q000201:enzymology; D010751:Phosphopyruvate Hydratase / Q000032:analysis*; D012189:Retrospective Studies; D009418:S100 Proteins / Q000032:analysis; D012871:Skin Diseases / Q000201:enzymology
chemical_list: D009418:S100 Proteins; D010751:Phosphopyruvate Hydratase