title: Influence of ethanol on the antiarrhythmic activity of verapamil.
abstract: The aim of this work was to determine the influence of ethanol on the antiarrhythmic activity of verapamil in the model of calcium arrhythmia in rats non-dependent and dependent on ethanol. The results of the experiment show that a combined, single administration of ethanol and verapamil attenuates in a statistically significant manner the antiarrhythmic effect of verapamil. Ethanol administered repeatedly together with verapamil does not diminish the antiarrhythmic activity of verapamil.
authors.affiliation: Department of Pharmacology, Medical Academy, Kraków, Poland.
authors.forename: B
authors.initials: B
authors.lastname: Filipek
authors.forename: J
authors.initials: J
authors.lastname: Krupińska
authors.forename: K
authors.initials: K
authors.lastname: Zebala
authors.forename: I
authors.initials: I
authors.lastname: Szymańska
authors.forename: T
authors.initials: T
authors.lastname: Librowski
authors.forename: W
authors.initials: W
authors.lastname: Piekoszewski
mesh_terms: D000437:Alcoholism / Q000150:complications; D000818:Animals; D001145:Arrhythmias, Cardiac / Q000139:chemically induced / Q000150:complications / Q000188:drug therapy*; D002122:Calcium Chloride; D004195:Disease Models, Animal; D004347:Drug Interactions; D000431:Ethanol / Q000097:blood / Q000633:toxicity*; D008297:Male; D051381:Rats; D014700:Verapamil / Q000494:pharmacology* / Q000627:therapeutic use
chemical_list: D000431:Ethanol; D014700:Verapamil; D002122:Calcium Chloride