Response of the esophageal epithelium to concomitant cis-dichlorodiammineplatinum(II) and radiation treatment. An electron microscopic study in rabbits.
The rabbit esophageal mucosa was irradiated with daily fractions of 2 Gy up to an accumulated dose of 20 Gy (total dose 2, 6, 10. 16 or 20 Gy). Fifteen to forty-five minutes before the start of each irradiation 0.3 mg Cis-dichlorodiammineplatinum (cis-DDP, cisplatinum) was given by intraperitoneal injection to each rabbit. Examinations were carried out 1-10 days after each fractionation schedule, when specimens were taken for morphological investigations. Scanning electron microscope (SEM) examination showed a gradual development of damage with cell loss and structural disarrangement of the microridges and whorls on the surface. However, with further treatment the esophageal mucosa exposed to cis-DDP and radiation normalized faster and more complete compared to the esophageal part exposed to cis-DDP alone. The difference may depend on an accelerated proliferation in the part of the trachea that is exposed to a combined treatment.
Albertsson
M
M
Department of Oncology, University Hospital, Lund, Sweden.
Cwikiel
M
M
Håkansson
C H
CH
Palmegren
M
M
D000818:Animals; D002455:Cell Division / Q000187:drug effects / Q000528:radiation effects; D002945:Cisplatin / Q000494:pharmacology*; D004848:Epithelium / Q000187:drug effects / Q000528:radiation effects / Q000648:ultrastructure; D004947:Esophagus / Q000187:drug effects / Q000528:radiation effects / Q000648:ultrastructure*; D008854:Microscopy, Electron; D008855:Microscopy, Electron, Scanning; D009092:Mucous Membrane / Q000648:ultrastructure; D011817:Rabbits
D002945:Cisplatin