title: Evaluation of colostral IgG1 absorption in newborn calves after treatment with alkalinizing agents.
abstract: The effects of alkalinizing agents, administered prior to feeding colostrum, on blood-gas and acid-base values and on absorption of IgG1 were determined in 40 newborn Holstein calves. Two treatments, sodium bicarbonate (3 mEq/kg of body weight, IV) and doxapram HCl (2 mg/kg, IV), were evaluated, using a randomized complete-block experimental design. These treatments resulted in significant (P less than 0.01) alteration of blood-gas and acid-base values, generally in the direction of normal values for adult cattle. Significant least squares mean effects were detected for sodium bicarbonate treatment on blood pH (+ 0.04 units, P less than 0.01), PCO2 (+ 4.1 mm of Hg, P less than 0.01), and HCO3 concentration (+ 4.4 mEq/L, P less than 0.01). Significant least squares mean effects were detected for doxapram HCl treatment on blood pH (+ 0.06 pH units, P less than 0.01) and PCO2 (-5.2 mm of Hg, P less than 0.01). Absorption of colostral IgG1 was not affected by the treatments given or by the altered blood-gas and/or acid-base status.
authors.affiliation: Department of Veterinary Microbiology and Pathology, College of Veterinary Medicine, Washington State University, Pullman 99164-7040.
authors.forename: M W
authors.initials: MW
authors.lastname: Ayers
authors.forename: T E
authors.initials: TE
authors.lastname: Besser
mesh_terms: D000042:Absorption; D000136:Acid-Base Equilibrium; D000818:Animals; D000831:Animals, Newborn / Q000378:metabolism*; D001639:Bicarbonates / Q000097:blood / Q000494:pharmacology*; D001784:Blood Gas Analysis; D002245:Carbon Dioxide / Q000097:blood; D002417:Cattle / Q000378:metabolism*; D003126:Colostrum / Q000276:immunology; D004315:Doxapram / Q000494:pharmacology*; D007074:Immunoglobulin G / Q000378:metabolism*; D016018:Least-Squares Analysis; D011897:Random Allocation; D012964:Sodium / Q000097:blood / Q000494:pharmacology*; D017693:Sodium Bicarbonate
chemical_list: D001639:Bicarbonates; D007074:Immunoglobulin G; D002245:Carbon Dioxide; D017693:Sodium Bicarbonate; D004315:Doxapram; D012964:Sodium