Comparative study of effects of cyclosporins A and G on collagen arthritis in mice.
The effects of the immunosuppressive agents cyclosporin G (CsG) and cyclosporin A (CsA) on collagen arthritis were compared in mice. When administered subcutaneously daily on days 0-13 after immunization with type II collagen, CsG and CsA were both capable of suppressing the development of collagen arthritis in mice as well as the immunological response to native type II collagen in a dose-dependent manner. Histopathologically, no marked inflammatory lesions were observed in diarthroidal joints from mice treated with 100 mg/kg per day of CsA or 800 mg/kg per day of CsG. However, an analysis of dose response showed CsG to be 8 times less potent than CsA in inhibiting the development of arthritis.
Takagishi
K
K
Department of Orthopedic Surgery, School of Medicine, Kitasato University, Kanagawa, Japan.
Yamamoto
M
M
Miyahara
H
H
Hotokebuchi
T
T
Kaibara
N
N
D000818:Animals; D001169:Arthritis, Experimental / Q000473:pathology / Q000517:prevention & control*; D003094:Collagen; D016572:Cyclosporine / Q000627:therapeutic use*; D003524:Cyclosporins / Q000627:therapeutic use*; D006968:Hypersensitivity, Delayed / Q000188:drug therapy; D007074:Immunoglobulin G / Q000032:analysis; D007166:Immunosuppressive Agents / Q000627:therapeutic use*; D007596:Joints / Q000473:pathology; D008297:Male; D051379:Mice; D008811:Mice, Inbred DBA
D003524:Cyclosporins; D007074:Immunoglobulin G; D007166:Immunosuppressive Agents; C045571:cyclosporin G; D016572:Cyclosporine; D003094:Collagen