Glycoprotein-specific immune response in canine herpesvirus infection.
Sera from dogs which were infected with canine herpesvirus (CHV) were analyzed for their serological reactivities against virus-specific glycoproteins (gps). By sequential immunoblot analysis using sera from experimentally infected dogs, it was found that the antibody response to gp 145/112 appeared first followed by responses to gp47 and gp80. In addition, all sera from naturally infected dogs which showed neutralizing activity to CHV reacted with gp 145/112, whereas 77% and 70% reacted with gp47 and gp80, respectively. Furthermore, some of the sera also cross-neutralized feline herpesvirus type 1 (FHV-1) and reacted with gp 143/108 of FHV-1, indicating that gp 145/112 of CHV induced cross-neutralizing antibody response to FHV-1.
Xuan
X
X
Department of Veterinary Microbiology, Faculty of Agriculture, University of Tokyo, Japan.
Horimoto
T
T
Limcumpao
J A
JA
Tohya
Y
Y
Takahashi
E
E
Mikami
T
T
D000818:Animals; D000914:Antibodies, Viral / Q000096:biosynthesis* / Q000276:immunology; D002415:Cats / Q000382:microbiology; D002460:Cell Line; D003429:Cross Reactions; D004283:Dog Diseases / Q000276:immunology / Q000382:microbiology*; D004285:Dogs; D006023:Glycoproteins / Q000276:immunology*; D006564:Herpesviridae / Q000276:immunology; D006566:Herpesviridae Infections / Q000276:immunology / Q000662:veterinary*; D002184:Herpesvirus 1, Canid / Q000276:immunology*; D015151:Immunoblotting; D014764:Viral Proteins / Q000276:immunology*
D000914:Antibodies, Viral; D006023:Glycoproteins; D014764:Viral Proteins