Oligonucleotide fingerprinting in Xiphophorus melanoma. Detection of a melanoma associated DNA modification.
Oligonucleotide fingerprints have been generated from fish melanomas and were compared to the constitutional multilocus patterns from normal brain DNA of the same individual. In 3 out of 8 cases additional bands were observed in the tumor DNA. This phenomenon can only be explained satisfactorily by so far unknown modes of DNA modification.
Mäueler
W
W
Ruhr-Universität, Bochum, Germany.
Schartl
M
M
Epplen
J T
JT
D000818:Animals; D003532:Cyprinodontiformes; D016172:DNA Fingerprinting; D004273:DNA, Neoplasm / Q000032:analysis*; D005393:Fish Diseases / Q000235:genetics*; D008545:Melanoma / Q000235:genetics / Q000662:veterinary*; D015345:Oligonucleotide Probes; D012878:Skin Neoplasms / Q000235:genetics / Q000662:veterinary*
D004273:DNA, Neoplasm; D015345:Oligonucleotide Probes