Dynamic control of inositol 1,4,5-trisphosphate-induced Ca2+ release: a theoretical explanation for the quantal release of Ca2+.
A theoretical model has been elaborated in order to describe the kinetics of Ca2+ release induced by inositol 1,4,5-trisphosphate (IP3). The model is based on the existence of a key molecule that controls the interconversion of open and closed forms of the Ca2+ channel. The model can quantitatively explain the previously obtained experimental observations that showed that a continuous IP3 stimulus leads to a biphasic Ca2+ release and that successive IP3 additions provoke repetitive bursts of Ca2+ release. Other published interpretations of these observations are discussed.
Swillens
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Institut de Recherche Interdisciplinaire, Université Libre de Bruxelles, Belgium.
D002118:Calcium / Q000378:metabolism*; D015220:Calcium Channels / Q000378:metabolism; D015544:Inositol 1,4,5-Trisphosphate / Q000502:physiology*; D007700:Kinetics; D008432:Mathematical Computing; D008954:Models, Biological; D011789:Quantum Theory
D015220:Calcium Channels; D015544:Inositol 1,4,5-Trisphosphate; D002118:Calcium