Quartromicin, a complex of novel antiviral antibiotics. I. Production, isolation, physico-chemical properties and antiviral activity.
A strain of Amycolatopsis orientalis No. Q427-8 (ATCC 53884) was found to produce a complex of new antiviral antibiotics, quartromicin which consisted of at least six components A1, A2, A3, D1, D2 and D3. Structural studies suggested that they are a novel type of molecules unrelated to any known antibiotics. Each component of quartromicin exhibited antiviral activity against herpes simplex virus type 1, influenza virus type A and human immunodeficiency virus.
Tsunakawa
M
M
Bristol-Myers Squibb Research Institute, Tokyo, Japan.
Tenmyo
O
O
Tomita
K
K
Naruse
N
N
Kotake
C
C
Miyaki
T
T
Konishi
M
M
Oki
T
T
D000192:Actinomycetales / Q000145:classification* / Q000378:metabolism; D000818:Animals; D000998:Antiviral Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000378:metabolism / Q000494:pharmacology; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D005285:Fermentation; D007783:Lactones / Q000737:chemistry / Q000302:isolation & purification / Q000378:metabolism / Q000494:pharmacology; D009682:Magnetic Resonance Spectroscopy; D009975:Orthomyxoviridae / Q000187:drug effects*; D018139:Simplexvirus / Q000187:drug effects*; D013141:Spiro Compounds / Q000737:chemistry / Q000302:isolation & purification / Q000378:metabolism / Q000494:pharmacology; D014709:Vero Cells
D000998:Antiviral Agents; D007783:Lactones; D013141:Spiro Compounds