[Calcium antagonists--determination of current status and therapeutic significance].
The important group of drugs known as calcium antagonists is surveyed from a clinico-pharmacological viewpoint. The recently introduced substances are presented in a detailed manner. Common features and differences in pharmacodynamics and pharmacokinetics of the individual calcium antagonists are explained and their differential therapeutic use in the treatment of chronic cardiovascular diseases is discussed. The article also reports on drug interferences, contraindications and possible extensions of indications. An assessment is made of results achieved so far when applying calcium antagonists in the treatment of chronic cardiovascular diseases and in the prevention of arteriosclerosis.
Regenthal
R
R
Institut für Klinische Pharmakologie, Universität Leipzig.
Voigt
H
H
Preiss
R
R
D002118:Calcium / Q000502:physiology; D002121:Calcium Channel Blockers / Q000009:adverse effects / Q000493:pharmacokinetics / Q000627:therapeutic use*; D002318:Cardiovascular Diseases / Q000097:blood / Q000188:drug therapy*; D006439:Hemodynamics / Q000187:drug effects; D006801:Humans; D007473:Ion Channels / Q000187:drug effects
D002121:Calcium Channel Blockers; D007473:Ion Channels; D002118:Calcium
Calciumantagonisten--Bestandsaufnahme und therapeutische Bedeutung.