Evaluation of hepatic fibrosis after oxamniquine therapy of murine schistosomiasis.
Chemical and histological indices of liver fibrosis were measured after eight, 18 and 28 weeks in mice infected with Schistosoma mansoni and treated at eight weeks with oxamniquine, in mice infected with S. mansoni and not treated and in mice not infected with S. mansoni. Total worm burdens and liver egg counts were determined in the infected mice to determine severity of infection. Treatment with oxamniquine resulted in near total eradication of S. mansoni worms after 10 weeks and in their complete killing and marked reduction of eggs in the liver at 10 and 20 weeks. Liver fibrosis 10 weeks after oxamniquine treatment was not significantly different than in the untreated, infected group but there was no progression between 10 and 20 weeks after oxamniquine treatment. Fibrosis did however increase between 10 and 20 weeks in the untreated infected group. In the murine model, oxamniquine is an effective treatment for S. mansoni and prevents progression of liver fibrosis.
Morcos
S H
SH
United States Naval Medical Research Unit No. 3 (NAMRU-3), Cairo, Egypt.
Mansour
M M
MM
Khayyal
M T
MT
Saleh
S
S
Ishak
E A
EA
Girgis
N I
NI
D000818:Animals; D006909:Hydroxyproline / Q000032:analysis; D008099:Liver / Q000737:chemistry / Q000469:parasitology; D008103:Liver Cirrhosis / Q000469:parasitology*; D008297:Male; D051379:Mice; D010073:Oxamniquine / Q000627:therapeutic use*; D010270:Parasite Egg Count; D012555:Schistosomiasis mansoni / Q000188:drug therapy*; D013997:Time Factors
D010073:Oxamniquine; D006909:Hydroxyproline