Prevalence of the A and B types of Epstein-Barr virus DNA in nasopharyngeal carcinoma biopsies from southern China.
Epstein-Barr virus (EBV) exists in the human population in two genetic forms, usually referred to as type A and type B. Although many earlier studies had indicated that the A type was generally predominant, there were suggestions that the B type may exhibit a preferential tropism for nasopharyngeal epithelial cells. This study examines the prevalence of the two forms of EBV DNA present in nasopharyngeal carcinoma biopsies obtained from the high incidence area of Southern China. The results obtained by Southern blot or polymerase chain reaction analyses show that in this patient group the A type of EBV is predominant.
Chen
X Y
XY
Cancer Research Campaign Laboratories, Paterson Institute for Cancer Research, Christie CRC Cancer Centre, Manchester, U.K.
Pepper
S D
SD
Arrand
J R
JR
D001483:Base Sequence; D015139:Blotting, Southern; D002681:China / Q000453:epidemiology; D004279:DNA, Viral / Q000032:analysis* / Q000737:chemistry; D004587:Electrophoresis, Agar Gel; D004854:Herpesvirus 4, Human / Q000145:classification / Q000235:genetics* / Q000302:isolation & purification; D006801:Humans; D008969:Molecular Sequence Data; D009303:Nasopharyngeal Neoplasms / Q000382:microbiology*; D009693:Nucleic Acid Hybridization; D016133:Polymerase Chain Reaction; D015995:Prevalence; D014412:Tumor Virus Infections / Q000453:epidemiology / Q000382:microbiology*
D004279:DNA, Viral