[Effect of protein content in rat diet on water-soluble vitamin metabolism in streptozotocin-induced diabetes].
Water-soluble group B vitamins metabolism was studied over the course of streptozotocin-induced diabetes mellitus in rats fed semisynthetic isocaloric diets containing 18 and 50% of protein. A high-protein diet in diabetes mellitus does not influence riboflavin metabolism disordered in this disease but reduced 4-pyridoxyl acid excretion to the level characteristic of healthy animals. The observed trend to an increase of liver nicotinamide coenzymes levels and of 1-methylnicotinamide urinary excretion reflects increased niacin synthesis from the diet protein tryptophan, for niacin level is reduced in diabetes.
Kodentsova
V M
VM
Sadykova
R E
RE
Dreval'
A V
AV
Vrzhesinskaia
O A
OA
Sokol'nikov
A A
AA
Beketova
N A
NA
D000818:Animals; D003067:Coenzymes / Q000378:metabolism; D003921:Diabetes Mellitus, Experimental / Q000378:metabolism*; D004044:Dietary Proteins / Q000008:administration & dosage / Q000494:pharmacology*; D008099:Liver / Q000201:enzymology; D008297:Male; D009525:Niacin / Q000096:biosynthesis; D009536:Niacinamide / Q000031:analogs & derivatives / Q000378:metabolism / Q000652:urine; D011730:Pyridoxal / Q000031:analogs & derivatives / Q000652:urine; D051381:Rats; D017208:Rats, Wistar; D012256:Riboflavin / Q000378:metabolism; D012995:Solubility; D014364:Tryptophan / Q000494:pharmacology; D014803:Vitamin B Complex / Q000378:metabolism*; D014867:Water / Q000737:chemistry
D003067:Coenzymes; D004044:Dietary Proteins; D014867:Water; D014803:Vitamin B Complex; D009536:Niacinamide; D009525:Niacin; D011730:Pyridoxal; D014364:Tryptophan; D012256:Riboflavin; C024058:N(1)-methylnicotinamide
Vliianie urovnia belka v ratsione krys na obmen vodorastvorimykh vitaminov pri streptozototsinovom diabete.