Variability in clinical pharmacology of drugs in children.
Numerous factors can lead to variability in pharmacokinetics, pharmacodynamics, efficacy, and toxicity of drugs in infants and children. These may include age, race or genetic status, organ function, underlying disease(s), drug formulation, concomitant drugs, and compliance with therapy. Further research is needed to clarify the mechanisms for variability in drug response to achieve optimal use of drugs in paediatric patients.
Nahata
M C
MC
College of Pharmacy, Ohio State University, Columbus 43210.
D002648:Child; D002657:Child Development / Q000502:physiology*; D002675:Child, Preschool; D006801:Humans; D007223:Infant; D007668:Kidney / Q000254:growth & development / Q000378:metabolism; D008099:Liver / Q000254:growth & development / Q000378:metabolism; D010599:Pharmacokinetics; D010600:Pharmacology