[Distribution of beta-carotene in the rat upon its intraperitoneal administration in water soluble and oil forms].
Accumulation and excretion of beta-carotene in rat liver tissue were studied when the carotinoid was intraperitoneally administered as olive oil as suspension and a water liposomal suspension. Single injection of the liposomal form of beta-carotene caused an increase in its content in liver tissue. If beta-carotene was administered at a dose of 10 mg/kg its maximal content 44 mg/g of the tissue was observed within one day, and at a dose of 50 mg/kg, its maximal content constituted 178 mg/g within two days. Administration of beta-carotene as an oil suspension at a dose of 50 mg/kg led to a considerably slight accumulation in rat liver tissue with the maximal value of 12 mg/kg of the tissue within two days. Possible use of beta-carotene various forms, as well as experimental models for study their biological activity are discussed.
Proskuriakov
S Ia
SIa
Riabchenko
N I
NI
Iakushina
L M
LM
Ivannik
V P
VP
Sin'kova
R V
RV
Konev
V V
VV
Popov
G A
GA
Riabchenko
V I
VI
Grosheva
I P
IP
D000818:Animals; D002338:Carotenoids / Q000008:administration & dosage / Q000737:chemistry / Q000493:pharmacokinetics*; D004042:Dietary Fats, Unsaturated; D007274:Injections, Intraperitoneal; D008081:Liposomes; D008099:Liver / Q000737:chemistry; D008297:Male; D000069463:Olive Oil; D010938:Plant Oils; D051381:Rats; D012995:Solubility; D014867:Water; D019207:beta Carotene
D004042:Dietary Fats, Unsaturated; D008081:Liposomes; D000069463:Olive Oil; D010938:Plant Oils; D019207:beta Carotene; D014867:Water; D002338:Carotenoids
Raspredelenie beta-karotina v organizme krys pri ego vnutribriushinnom vvedenii v vide vodorastvorimoĭ i maslianoĭ form.