[The characteristics of the action of ethanol in operators with different states of the skin tissue basophils].
The changes in some parameters of an operator activity after ethanol administration at a dose of 1.9 g/kg body weight in 10 men doing the job of two-dimensional compensatory tracking in simulator, have been studied. In this case, the population state of tissue basophils (mast cells) of the body by studying the amounts of various structural and metabolic forms of these cells, contained in the skin biopsies, was studied. The degree of deterioration in operator activity was evaluated separately for the subjects with the population characteristics of tissue basophils higher or lower than mean values. It is indicated that the subjects with a low initial number of tissue basophils exhibiting signs of a holocrine-typed secretion and with a more pronounced response of these cells to ethanol were characterized by a significantly higher degree of the impairing many parameters of operator activity. Such differences were especially marked immediately after ethanol administration and practically lacked 12 hours after.
Ushakov
I B
IB
Tikhonchuk
V S
VS
Razinkin
S M
SM
Kordenko
A N
AN
Pakhunova
L V
LV
D000328:Adult; D001491:Basophils / Q000166:cytology / Q000187:drug effects*; D001706:Biopsy; D000431:Ethanol / Q000494:pharmacology*; D006801:Humans; D008297:Male; D011597:Psychomotor Performance / Q000187:drug effects; D012867:Skin / Q000166:cytology / Q000187:drug effects*; D013997:Time Factors
D000431:Ethanol
Osobennost' deĭstviia étanola u operatorov s raznym sostoianiem tkanevykh bazofilov kozhi.