[The prophylactic administration of interleukin-2 increases the survival of mice with an acute intra-abdominal infection caused by Staphylococcus aureus].
The effect of RIL-2 on the survival of mice with acute Staphylococcus aureus strain 5/2 intra-abdominal [correction of intraperitoneal] infection was studied. RIL-2 was ineffective when administered simultaneously with the LD100 dose of bacteria. Antibiotics (gentamycin or combination of penicillin and streptomycin) administered in the same fashion cured 100% of animals. However, RIL-2 proved to be effective when administered simultaneously with LD70 dose of bacteria. The prophylactic course of RIL-2 consisting of repeated injections on days 3, 2 and 1 before the challenge with LD100 dose of bacteria also resulted in the marked increase of the survival of mice. The hypothetical mechanisms of action and the prospects of RIL-2 application are discussed.
Shadrin
O V
OV
Khar'kovskaia
N A
NA
Dronova
O M
OM
Bykovskaia
S N
SN
D000005:Abdomen; D000208:Acute Disease; D000818:Animals; D000900:Anti-Bacterial Agents / Q000008:administration & dosage; D016009:Chi-Square Distribution; D004195:Disease Models, Animal; D004353:Drug Evaluation, Preclinical; D004359:Drug Therapy, Combination; D005260:Female; D007376:Interleukin-2 / Q000008:administration & dosage*; D008297:Male; D051379:Mice; D011994:Recombinant Proteins / Q000008:administration & dosage; D013203:Staphylococcal Infections / Q000453:epidemiology / Q000401:mortality / Q000517:prevention & control*
D000900:Anti-Bacterial Agents; D007376:Interleukin-2; D011994:Recombinant Proteins
Profilakticheskoe vvedenie interleĭkina-2 uvelichivaet vyzhivaemost' mysheĭ s ostroĭ vnutribriushnoĭ infektsieĭ, vyzvannoĭ Staphylococcus aureus.