title: Relationship between digestive and killing abilities of neutrophils against Paracoccidioides brasiliensis.
abstract: Peripheral blood neutrophils (PMN) from patients with paracoccidioidomycosis killed and digested Paracoccidioides brasiliensis much less than did PMN from normal individuals or from patients with other diseases. However, deficiency in killing ability was less specific than digestive deficiency and correlated poorly with it. We conclude that the capacities of PMN to digest and kill P. brasiliensis are not intimately related phenomena, and that in paracoccidioidomycosis the key deficiency of neutrophil function is that of digestion of P. brasiliensis.
authors.affiliation: Section of Immunology I, Central University of Venezuela.
authors.forename: M
authors.initials: M
authors.lastname: Goihman-Yahr
authors.forename: J
authors.initials: J
authors.lastname: Pereira
authors.forename: G
authors.initials: G
authors.lastname: Istúriz
authors.forename: N
authors.initials: N
authors.lastname: Viloria
authors.forename: M
authors.initials: M
authors.lastname: Carrasquero
authors.forename: N
authors.initials: N
authors.lastname: Saavedra
authors.forename: M H
authors.initials: MH
authors.lastname: de Gómez
authors.forename: A
authors.initials: A
authors.lastname: Román
authors.forename: B
authors.initials: B
authors.lastname: San Martín
authors.forename: M C
authors.initials: MC
authors.lastname: Bastardo de Albornoz
mesh_terms: D000328:Adult; D000704:Analysis of Variance; D003601:Cytotoxicity Tests, Immunologic; D005260:Female; D006801:Humans; D066298:In Vitro Techniques; D008297:Male; D008875:Middle Aged; D009504:Neutrophils / Q000378:metabolism / Q000502:physiology*; D010228:Paracoccidioides / Q000276:immunology*; D010229:Paracoccidioidomycosis / Q000276:immunology* / Q000382:microbiology