[The effect of hormonal systems on the activity of convulsant agents].
The dynamics of convulsive action exerted by Bemegride, 15 mg/kg, and Corasol (Pentamethylenetetrasol, 50 mg/kg, was examined in rat experiments during extirpation of endocrine glands (pituitary, thyroid, adrenals and gonads). Their effects were found to be unequal in various series of experiments: thyroidectomy intensified the nature of convulsive reactions while gonadectomy attenuated them; sex-specific differences in the effects of the agents were insignificant. It has been suggested that the hormone-mediator interaction is essential in the mechanisms of convulsive action of Bemegride and Corasol.
Sapronov
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D000305:Adrenal Cortex Hormones / Q000502:physiology; D000818:Animals; D001534:Bemegride / Q000494:pharmacology; D003292:Convulsants / Q000494:pharmacology*; D005260:Female; D012739:Gonadal Steroid Hormones / Q000502:physiology; D006728:Hormones / Q000502:physiology*; D008297:Male; D010433:Pentylenetetrazole / Q000494:pharmacology; D010907:Pituitary Hormones / Q000502:physiology; D051381:Rats; D011930:Reaction Time / Q000187:drug effects; D012640:Seizures / Q000139:chemically induced / Q000503:physiopathology; D013963:Thyroid Hormones / Q000502:physiology
D000305:Adrenal Cortex Hormones; D003292:Convulsants; D012739:Gonadal Steroid Hormones; D006728:Hormones; D010907:Pituitary Hormones; D013963:Thyroid Hormones; D001534:Bemegride; D010433:Pentylenetetrazole
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