A simple and convenient method for acyclonucleoside synthesis.
Introduction of acyclic chain for synthesis of acyclonucleoside derivatives was achieved in a simple and convenient way. Silylated pyrimidine or purine bases were treated with 1,3-dioxolane, trimethyl chlorosilane and metal iodide, such as KI and NaI, all together at room temperature. By this method, 2-thiopyrimidine derivatives were also obtained in good yield, using 2 molecular equivalents of 1,3-dioxolane.
Ubasawa
M
M
Mitsubishi Kasei Corporation, Yokohama, Japan.
Takashima
H
H
Sekiya
K
K
D004148:Dioxolanes / Q000737:chemistry; D007202:Indicators and Reagents; D007454:Iodides / Q000737:chemistry; D009705:Nucleosides / Q000138:chemical synthesis*; D013941:Thymine / Q000737:chemistry; D014297:Trimethylsilyl Compounds / Q000737:chemistry
D004148:Dioxolanes; D007202:Indicators and Reagents; D007454:Iodides; D009705:Nucleosides; D014297:Trimethylsilyl Compounds; C039293:trimethylchlorosilane; D013941:Thymine; C010962:formal glycol