title: Monoclonal antibody MON-114: detection of a marker for neuroendocrine differentiation in human lung cancer.
abstract: Mouse monoclonal antibody MON-114 was generated upon immunization with a human small cell lung carcinoma cell line GLC-19. Immunohistochemical analysis of normal tissues with MON-114 showed staining of the adrenal gland, brain and peripheral nerves. With respect to human lung carcinomas, 7 out of 8 small cell lung carcinomas were positively stained as well as 5 out of 5 carcinoid tumors, whereas only 4 out of 31 squamous cell carcinomas and 3 out of 19 adenocarcinomas were weakly stained. Furthermore, 1 large cell carcinoma was negative for MON-114 staining. Apparently, MON-114 stains cells of neuroendocrine differentiation.
authors.affiliation: Department of Biochemistry, University of Nijmegen, The Netherlands.
authors.forename: H L
authors.initials: HL
authors.lastname: van Duijnhoven
authors.forename: E H
authors.initials: EH
authors.lastname: Moors
authors.forename: A
authors.initials: A
authors.lastname: Groeneveld
authors.forename: E D
authors.initials: ED
authors.lastname: Timmer
authors.forename: L F
authors.initials: LF
authors.lastname: de Leij
authors.forename: S S
authors.initials: SS
authors.lastname: Wagenaar
authors.forename: J M
authors.initials: JM
authors.lastname: Polak
authors.forename: W J
authors.initials: WJ
authors.lastname: van de Ven
mesh_terms: D000818:Animals; D000911:Antibodies, Monoclonal; D000951:Antigens, Neoplasm / Q000032:analysis*; D014408:Biomarkers, Tumor / Q000032:analysis*; D002289:Carcinoma, Non-Small-Cell Lung / Q000276:immunology*; D018288:Carcinoma, Small Cell / Q000276:immunology*; D006801:Humans; D008175:Lung Neoplasms / Q000276:immunology*; D051379:Mice; D008807:Mice, Inbred BALB C
chemical_list: D000911:Antibodies, Monoclonal; D000951:Antigens, Neoplasm; D014408:Biomarkers, Tumor