Induction of anti-Escherichia coli activity in mice by phenothiazines, benzo[a]phenothiazines and benz[c]acridines.
The abilities of 14 phenothiazines, 8 benzo[a]phenothiazines and 12 benz[c]acridines to induce anti-Escherichia coli activity in mice were compared. Pretreatment with several benzo[a]phenothiazines or benz[c]acridines protected mice from lethal infection of Escherichia coli in a dose-dependent manner, whereas most of the phenothiazines induced much weaker anti-Escherichia coli activity. However, direct contact of Escherichia coli with these compounds or their administration just after bacterial inoculation were ineffective. These data suggest the immunopotentiation activity of benzo[a]phenothiazines and benz[c]acridines.
Motohashi
N
N
Department of Medicinal Chemistry, Meiji College of Pharmacy, Tokyo, Japan.
Sakagami
H
H
Komatsu
N
N
Fujimaki
M
M
Wada
C
C
Molnar
J
J
D000166:Acridines / Q000494:pharmacology*; D000276:Adjuvants, Immunologic / Q000494:pharmacology*; D000818:Animals; D004926:Escherichia coli; D004927:Escherichia coli Infections / Q000276:immunology / Q000517:prevention & control; D051379:Mice; D008813:Mice, Inbred ICR / Q000276:immunology; D010640:Phenothiazines / Q000494:pharmacology*
D000166:Acridines; D000276:Adjuvants, Immunologic; D010640:Phenothiazines; C035985:benz(c)acridine