Action of the N-methyl-D-aspartate receptor antagonist MK-801 against focal seizure activity from the feline hippocampus.
This study assessed the effects of MK-801 (0.1 and 0.5 mg/kg), a noncompetitive antagonist of N-methyl-D-aspartate receptors, on focal seizure activity elicited by electrical stimulation to the feline hippocampus. Neither afterdischarge duration nor behavioral seizure stage was significantly suppressed following intraperitoneal administration of MK-801 at two dose. Rather, MK-801 at a higher dose induced hippocampal seizure status in some of the cats tested. The present data suggest convulsant properties of MK-801 and limitations of its clinical utility as an antiepileptic agent.
Wada
Y
Y
Department of Neuropsychiatry, Kanazawa University School of Medicine, Japan.
Hasegawa
H
H
Nakamura
M
M
Yamaguchi
N
N
D000818:Animals; D002415:Cats; D016291:Dizocilpine Maleate / Q000494:pharmacology*; D004558:Electric Stimulation; D004569:Electroencephalography / Q000187:drug effects*; D004828:Epilepsies, Partial / Q000503:physiopathology*; D005071:Evoked Potentials / Q000187:drug effects; D005260:Female; D006624:Hippocampus / Q000187:drug effects* / Q000503:physiopathology; D007274:Injections, Intraperitoneal; D008297:Male; D009044:Motor Cortex / Q000187:drug effects / Q000503:physiopathology; D016194:Receptors, N-Methyl-D-Aspartate / Q000037:antagonists & inhibitors* / Q000502:physiology; D014793:Visual Cortex / Q000187:drug effects / Q000503:physiopathology
D016194:Receptors, N-Methyl-D-Aspartate; D016291:Dizocilpine Maleate