Influence of nifedipine on aortal cholesterol content, blood coagulation and elastin metabolism in cholesterol-fed rabbits.
Our studies showed that the nifedipine in daily doses of 30 mg/kg given to rabbits treated with a diet containing 1% cholesterol for 6 months, decreased cholesterol content in aorta homogenates, urine excretion of desmosines and prolonged partial thromboplastin time, while it did not alter serum lipids. These results may have some value for understanding of the antiatherogenic mechanism of nifedipine.
Klin
M J
MJ
Department of Clinical Pharmacology, Medical Academy, Katowice, Poland.
Wystrychowski
A
A
Grzebieniak
E
E
Sobczak
A
A
Bochenek
R
R
Wesołowski
W
W
Herman
Z S
ZS
D000704:Analysis of Variance; D000818:Animals; D001011:Aorta / Q000187:drug effects* / Q000378:metabolism; D002784:Cholesterol / Q000378:metabolism*; D002791:Cholesterol, Dietary / Q000008:administration & dosage; D003895:Desmosine / Q000652:urine; D004549:Elastin / Q000378:metabolism*; D005340:Fibrinogen / Q000032:analysis; D008055:Lipids / Q000097:blood; D008297:Male; D009543:Nifedipine / Q000008:administration & dosage / Q000494:pharmacology*; D010314:Partial Thromboplastin Time; D010958:Plasminogen / Q000032:analysis; D011517:Prothrombin Time; D011817:Rabbits; D013918:Thrombin Time
D002791:Cholesterol, Dietary; D008055:Lipids; D003895:Desmosine; D005340:Fibrinogen; D010958:Plasminogen; D004549:Elastin; D002784:Cholesterol; D009543:Nifedipine