A murine CD4-, CD8- T cell receptor-gamma delta T lymphocyte clone specific for herpes simplex virus glycoprotein I.
The role of TCR-gamma delta T lymphocytes in immune responses is currently not well understood. TCR-gamma delta cells have a limited repertoire suggesting that TCR-gamma delta T a limited number of evolutionarily conserved Ag such as nonpolymorphic MHC and heat shock proteins. TCR-gamma delta T lymphocytes appear in enhanced numbers in skin lesions produced by Mycobacterium leprae and in the synovial fluid of joints affected by rheumatoid arthritis, raising the possibility that this subset of T lymphocytes may play a role in control of infectious processes and in autoimmune diseases. We report the identification of a TCR-gamma delta T cell clone isolated from a HSV-infected mouse that recognizes glycoprotein I of HSV type 1. Clone recognition of glycoprotein I does not appear to require the expression of MHC class I or class II gene products. These data suggest that TCR-gamma delta lymphocytes may play an important role in the immune response to viral infections.
Johnson
R M
RM
Department of Pathology, University of Chicago, IL 60637.
Lancki
D W
DW
Sperling
A I
AI
Dick
R F
RF
Spear
P G
PG
Fitch
F W
FW
Bluestone
J A
JA
D000818:Animals; D015704:CD4 Antigens / Q000032:analysis*; D016827:CD8 Antigens / Q000032:analysis*; D002999:Clone Cells; D006023:Glycoproteins / Q000276:immunology*; D006561:Herpes Simplex / Q000276:immunology; D051379:Mice; D008815:Mice, Inbred Strains; D016692:Receptors, Antigen, T-Cell, gamma-delta / Q000032:analysis*; D018139:Simplexvirus / Q000276:immunology*; D013601:T-Lymphocytes / Q000276:immunology / Q000502:physiology*; D014759:Viral Envelope Proteins / Q000276:immunology*
D015704:CD4 Antigens; D016827:CD8 Antigens; D006023:Glycoproteins; D016692:Receptors, Antigen, T-Cell, gamma-delta; D014759:Viral Envelope Proteins