Adenine nucleotide concentrations and energy charge in muscle of chronic haemodialysis patients.
Adenine nucleotide concentrations and energy charge ratios were measured in muscle samples collected during transplant surgery of 7 patients suffering from chronic renal failure and undergoing haemodialysis. The energy charge ratio of 0.75 in the muscle of transplant patients was significantly lower (p less than 0.01) than that of 0.89 found in muscle from controls. The lower energy charge ratio and increased concentrations of adenosine diphosphate and adenosine monophosphate may contribute to the patients' reduced exercise ability and their poor metabolic state.
Cleminson
W G
WG
Department of Biochemistry, University of the Witwatersrand, Johannesburg, South Africa.
Manchester
K L
KL
Diesel
W J
WJ
Margolius
L P
LP
D000227:Adenine Nucleotides / Q000032:analysis* / Q000378:metabolism; D000244:Adenosine Diphosphate / Q000032:analysis; D000249:Adenosine Monophosphate / Q000032:analysis; D000293:Adolescent; D000328:Adult; D004734:Energy Metabolism / Q000502:physiology*; D015444:Exercise / Q000502:physiology; D005260:Female; D006801:Humans; D007676:Kidney Failure, Chronic / Q000378:metabolism* / Q000503:physiopathology* / Q000628:therapy; D008297:Male; D008875:Middle Aged; D009132:Muscles / Q000737:chemistry* / Q000378:metabolism / Q000502:physiology*; D006435:Renal Dialysis
D000227:Adenine Nucleotides; D000249:Adenosine Monophosphate; D000244:Adenosine Diphosphate