Influence of blood glucose levels on peripheral lymphocytes in patients with diabetes mellitus.
Abnormalities in lymphocyte subpopulations in patients with type 1 diabetes have been reported previously. To evaluate the effect of blood glucose levels on peripheral lymphocyte concentrations we studied the proportion and phenotypic composition of the T-cell population in 7 patients with type 1 and in 12 patients with type 2 diabetes at hospitalization because of metabolic dysregulation and in a period of restored control. Both the number of CD-4 and CD-8 positive cells increased significantly (p < 0.05), although no change in the CD-4:CD-8 ratio was observed. After restoring metabolic control there was a significant rise in the mean number of total lymphocytes (1760 +/- 759 x 10(6)/ml vs 2385 +/- 889 x 10(6)/ml, p < 0.05). The number of total lymphocytes increased in all patients but one. It is concluded that metabolic control can influence immunological parameters such as numbers of peripheral lymphocytes of various phenotypes.
Bouter
K P
KP
Department of Internal Medicine, Bosch Medicentre, Den Bosch, The Netherlands.
Meyling
F H
FH
Hoekstra
J B
JB
Masurel
N
N
Erkelens
D W
DW
Diepersloot
R J
RJ
D000328:Adult; D000368:Aged; D001786:Blood Glucose / Q000502:physiology*; D015704:CD4 Antigens / Q000032:analysis; D016827:CD8 Antigens / Q000032:analysis; D003168:Complement Fixation Tests; D003922:Diabetes Mellitus, Type 1 / Q000097:blood* / Q000276:immunology*; D003924:Diabetes Mellitus, Type 2 / Q000097:blood* / Q000276:immunology*; D005260:Female; D006442:Glycated Hemoglobin / Q000032:analysis; D006801:Humans; D016130:Immunophenotyping; D007958:Leukocyte Count; D008297:Male; D016176:T-Lymphocyte Subsets / Q000276:immunology*
D001786:Blood Glucose; D015704:CD4 Antigens; D016827:CD8 Antigens; D006442:Glycated Hemoglobin