Effects of clonazepam on picrotoxin-induced convulsions.
The convulsant effects of four doses of picrotoxin (PX)-2, 3, 4, and 6 mg/kg s.c.-were evaluated in the first part of the study. The 4-mg/kg dose, which elicited minimal seizures in all animals, generalized tonic-clonic (major) seizures in 75% of rats and fatal outcome in 69% of rats, was chosen for the second part, i.e. for testing the anticonvulsant action of clonazepam (Rivotril Roche, 0.1 or 1 mg/kg i.p.). Clonazepam exhibited a dose-dependent action against PX-induced seizures, being more efficient against major than against minimal seizures.
Kubová
M
M
Institute of Physiology, Czechoslovak Academy of Sciences, Prague.
Bohuslav
T
T
Mares
P
P
D000818:Animals; D000927:Anticonvulsants / Q000494:pharmacology; D002998:Clonazepam / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D004827:Epilepsy / Q000139:chemically induced / Q000503:physiopathology / Q000517:prevention & control; D007274:Injections, Intraperitoneal; D010852:Picrotoxin; D051381:Rats; D017208:Rats, Wistar; D012640:Seizures / Q000139:chemically induced / Q000503:physiopathology / Q000517:prevention & control*
D000927:Anticonvulsants; D002998:Clonazepam; D010852:Picrotoxin