title: Neurotensin secretion in response to intraduodenal and intraileal administration of fat in dogs.
abstract: Release of neurotensin from the small intestine in response to administration of fat directly into the duodenum and ileum was examined in conscious dogs. The present results show that: (1) intraduodenal administration of fat causes a diphasic release of neurotensin which is mediated, at least in part, by cholinergic mechanisms, and (2) both a fatty acid (sodium oleate) and a triglyceride, when infused directly into an isolated ileal loop, stimulate a significant release of neurotensin. Our findings indicate that release of neurotensin is triggered by mechanisms originating in the proximal small intestine and by a direct contact of nutrients with the ileal mucosa.
authors.affiliation: Department of Surgery, University of Texas Medical Branch, Galveston 77555-0527.
authors.forename: T
authors.initials: T
authors.lastname: Miyashita
authors.forename: T
authors.initials: T
authors.lastname: Hashimoto
authors.forename: G
authors.initials: G
authors.lastname: Gomez
authors.forename: C M
authors.initials: CM
authors.lastname: Townsend
authors.forename: G H
authors.initials: GH
authors.lastname: Greeley
authors.forename: J C
authors.initials: JC
authors.lastname: Thompson
mesh_terms: D000818:Animals; D002799:Cholinergic Fibers / Q000502:physiology; D004041:Dietary Fats / Q000008:administration & dosage*; D004285:Dogs; D004386:Duodenum / Q000294:innervation / Q000378:metabolism; D007082:Ileum / Q000294:innervation / Q000378:metabolism; D009496:Neurotensin / Q000378:metabolism*; D019301:Oleic Acid; D009829:Oleic Acids / Q000008:administration & dosage; D014280:Triglycerides / Q000008:administration & dosage
chemical_list: D004041:Dietary Fats; D009829:Oleic Acids; D014280:Triglycerides; D019301:Oleic Acid; D009496:Neurotensin; C013173:osteum