title: Rheology of the vitreous body. Part I: Viscoelasticity of human vitreous.
abstract: The rheological properties of the vitreous body of the eye are believed to be a function of composition and to differ among species, as well as to vary regionally within the vitreous. These properties are essential to the mechanical functioning of the eye. Although there are gross, qualitative data on vitreous rheology available in the literature, quantitative rheological measurements on human vitreous and on eyes of other species are sparse and incomplete. The aim of the research reported in this series of papers is to study the rheological behavior of human, bovine, and porcine vitreous, to measure the macromolecular and electrolyte content of these samples, and to correlate and compare these values for the different species as a function of location in the vitreous. In this paper, the rheological model used to correlate viscoelasticity of the vitreous is presented, and a detailed description of the rheological instrumentation and methods of analysis used is given. Data on the rheological properties of human vitreous, as a function of location within the eye, are presented. The results show that in the human eye there are significant differences in a number of the viscoelastic parameters as a function of location within the vitreous body.
authors.affiliation: Department of Bioengineering, University of Pennsylvania, Philadelphia 19104.
authors.forename: B
authors.initials: B
authors.lastname: Lee
authors.forename: M
authors.initials: M
authors.lastname: Litt
authors.forename: G
authors.initials: G
authors.lastname: Buchsbaum
mesh_terms: D004548:Elasticity; D006801:Humans; D008954:Models, Biological; D012212:Rheology / Q000295:instrumentation; D014783:Viscosity; D014822:Vitreous Body / Q000033:anatomy & histology / Q000502:physiology*