Growth and sexual maturation of Brazilian patients with sickle cell diseases.
Growth and sexual maturation was studied of 125 Brazilian patients with sickle cell disease whose ages ranged from 7 months to 42 years. Height and weight were significantly lower when compared with the unaffected population. The height and weight deficit increased in the age range of 11-19 years as compared with patients less than 11 years of age. Age of menarche, breast and pubic hair staging in girls, and genitalia staging and testicular volume measurements in boys indicated a delayed sexual maturation for both sexes. The comparison of adult and young patients, however, demonstrated that although puberty is delayed, a normal sexual maturation is attained later in life by most patients.
Zago
M A
MA
Departamento de Clínica Médica, Faculdade de Medicina de Ribeirão Preto, Universidade de S. Paulo.
Kerbauy
J
J
Souza
H M
HM
Figueiredo
M S
MS
Costa
F F
FF
Cruz
S M
SM
Braga
J A
JA
Alvarenga
D
D
Ribeiro
J U
JU
Tone
L G
LG
D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000755:Anemia, Sickle Cell / Q000150:complications* / Q000235:genetics; D001827:Body Height; D001835:Body Weight; D001938:Brazil / Q000453:epidemiology; D002648:Child; D002675:Child, Preschool; D005260:Female; D006130:Growth Disorders / Q000175:diagnosis / Q000453:epidemiology* / Q000209:etiology; D006579:Heterozygote; D006720:Homozygote; D006801:Humans; D007223:Infant; D008297:Male; D010044:Outpatient Clinics, Hospital; D011628:Puberty, Delayed / Q000175:diagnosis / Q000453:epidemiology* / Q000209:etiology; D012741:Sexual Maturation; D017086:beta-Thalassemia / Q000150:complications* / Q000235:genetics