[Pharmacokinetics of phenazone after bilateral ovariectomy in female rabbits].
The aim of this study was to evaluate the influence of female sex hormones on phenazone pharmacokinetics using as an experimental model female rabbits after a bilateral ovariectomy. Eighteen female rabbits divided into two groups: control animals and experimental rabbits, that underwent ovariectomy, were used in the study. Pharmacokinetic assays were performed in all animals: prior to the study, after 1 month and after 2 months. Blood was sampled within 24 hours after intragastric administration of phenazone at a dose 50 mg/kg b.w. Two compartment open model was used for calculations. Significant increase in AUC and prolongation of phenazone halflife as well as a decrease in the total body clearance were noted. The study demonstrated the possible inhibition of the microsomal mixed-function oxidase system by oestrogens.
Gawrońska-Szklarz
B
B
Zakładu Farmakologii Klinicznej PAM, Szczecinie.
Kwiatkowski
A
A
Droździk
M
M
Wójcicki
J
J
D000818:Animals; D000983:Antipyrine / Q000493:pharmacokinetics*; D004967:Estrogens / Q000502:physiology; D005260:Female; D006207:Half-Life; D008657:Metabolic Clearance Rate; D010052:Ovariectomy; D011817:Rabbits
D004967:Estrogens; D000983:Antipyrine
Farmakokinetyka fenazonu po usunieciu jajników u królic.