Antimicrobial activity of benzydamine, a non-steroid anti-inflammatory agent.
The antimicrobial activity of benzydamine (BD), a non-steroid anti-inflammatory agent, was studied using different techniques against 38 strains belonging to 12 microbial species comprising bacteria, yeasts and a fungus. The minimum inhibitory concentrations, minimum lethal concentrations, per cent survivors after 30-minute exposure to BD (0.1%), growth curves of 7 selected organisms in subinhibitory BD concentrations and killing times for clinical isolates at different BD levels (0.05-0.15%) were determined. The data obtained throughout this study show that BD is a general antimicrobial agent with a rapid biocidal activity against a variety of organisms at concentrations less than those advocated for treatment of inflammatory conditions.
Fanaki
N H
NH
Department of Pharmaceutical Microbiology, Alexandria University, Egypt.
el-Nakeeb
M A
MA
D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents / Q000494:pharmacology*; D001591:Benzydamine / Q000494:pharmacology*; D006090:Gram-Negative Bacteria / Q000187:drug effects / Q000254:growth & development; D006094:Gram-Positive Bacteria / Q000187:drug effects / Q000254:growth & development; D008826:Microbial Sensitivity Tests; D013045:Species Specificity; D013997:Time Factors; D015003:Yeasts / Q000187:drug effects / Q000254:growth & development
D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents; D001591:Benzydamine