Studies on some 10-[2-(N,N-disubstituted thiocarbamoylthio)acetyl]phenothiazine derivatives.
Nineteen 10-[2-(N,N-disubstituted thiocarbamoylthio) acetyl]phenothiazine derivatives have been synthesized by the reaction of 10-chloroacetylphenothiazine with potassium salt of N,N-disubstituted dithiocarbamic acid derivatives. The structures of the compounds have been elucidated by UV, IR, 1H-NMR spectra and microanalysis. The anticholinergic activity of the compounds was determined by assessing the inhibition of acetylcholine using atropine sulfate as a control. Results are discussed in relation to the activity and structure of the synthesized compounds.
Palaska
E
E
Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Hacettepe University, Ankara, Turkey.
Sarac
S
S
Safak
C
C
Erdogan
H
H
Erol
K
K
Alpan
R S
RS
D000109:Acetylcholine / Q000494:pharmacology; D000818:Animals; D001285:Atropine / Q000494:pharmacology; D005260:Female; D066298:In Vitro Techniques; D007537:Isometric Contraction / Q000187:drug effects; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D009119:Muscle Contraction / Q000187:drug effects; D009131:Muscle, Smooth, Vascular / Q000187:drug effects; D010276:Parasympatholytics / Q000138:chemical synthesis* / Q000494:pharmacology; D010640:Phenothiazines / Q000138:chemical synthesis* / Q000494:pharmacology; D051381:Rats; D013056:Spectrophotometry, Ultraviolet; D013329:Structure-Activity Relationship; D013859:Thiocarbamates / Q000138:chemical synthesis* / Q000494:pharmacology
D010276:Parasympatholytics; D010640:Phenothiazines; D013859:Thiocarbamates; D001285:Atropine; D000109:Acetylcholine