title: Radiation-induced optic neuropathy.
abstract: Radiation-induced optic neuropathy is a well-known complication of cranial radiotherapy. We describe four cases. In two cases, the diagnosis was made on MRI. After administration of Gadolinium-DTPA, there was an enhanced captation at the level of the optic nerve. In addition we reviewed 47 cases reported in the literature. Visual prognosis is less than 1/10 in 78% of affected eyes. In case of associated brain necrosis, the mortality rate is 62%.
authors.affiliation: Department of Ophthalmology, University Hospital, Ghent, Belgium.
authors.forename: G
authors.initials: G
authors.lastname: Sallet
authors.forename: P
authors.initials: P
authors.lastname: Kestelyn
mesh_terms: D000328:Adult; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009336:Necrosis; D009900:Optic Nerve / Q000528:radiation effects; D009901:Optic Nerve Diseases / Q000209:etiology*; D010910:Pituitary Irradiation / Q000009:adverse effects*; D010911:Pituitary Neoplasms / Q000175:diagnosis / Q000532:radiotherapy; D011832:Radiation Injuries / Q000209:etiology*; D011879:Radiotherapy Dosage