[The action on brain functions in white rats of the immunostimulant Freund's complete adjuvant].
The effect of immunostimulator--Freund's adjuvant complete on the nociception and learning of white rats using food-obtaining and avoidance of electric shock techniques has been studied. It has been shown that the adjuvant in doses for active immunization causes itself the expressed changes in animal behaviour. The adjuvant's injections significantly increases the learning ability of animals both with negative and positive reinforcement as compared with control one. The changes in pain severity is marked only for dose 0.2 ml. The nonspecific action of adjuvant should be taken into account in researches which use the active immunisation method.
Kustova
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EV
Danilova
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RA
Ashmarin
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IP
D000818:Animals; D001362:Avoidance Learning / Q000187:drug effects; D001921:Brain / Q000187:drug effects* / Q000502:physiology; D003214:Conditioning, Classical / Q000187:drug effects; D005247:Feeding Behavior / Q000187:drug effects; D005620:Freund's Adjuvant / Q000494:pharmacology*; D008297:Male; D009043:Motor Activity / Q000187:drug effects; D017288:Pain Threshold / Q000187:drug effects; D051381:Rats; D011930:Reaction Time / Q000187:drug effects; D012054:Reinforcement, Psychology; D013997:Time Factors
D005620:Freund's Adjuvant
Deĭstvie na nekotorye funktsii mozga belykh krys immunostimuliatora--polnogo ad''iuvanta Freĭnda.