Effect of zinc sulfate and acetylcysteine on experimental gastric ulcer: in vitro study.
A small ulcer produced in vitro by monopolar electrocoagulation on endoscopically obtained human antral biopsies and incubated in Trowel T-8 medium at 37 degrees C for 8 h has many histologic features of chronic gastric ulcer in man. Zinc sulfate and acetylcysteine in low concentrations had a significant healing effect in this ulcer model. Since the beneficial effect of zinc sulfate and acetylcysteine was counteracted by N-ethylmaleimide, a known blocker of sulfhydryl compounds, the beneficial effect of these two compounds probably was mediated through sulfhydryl compounds. Using special stain, N-(4-aminophenyl)maleimide, the sulfhydryl groups were localized in the epithelial cells of the surface layer and gastric glands.
Mann
N S
NS
Department of Medicine, Texas A & M University College of Medicine, Temple.
Mann
S K
SK
Brawn
P N
PN
Weaver
B
B
D000111:Acetylcysteine / Q000494:pharmacology*; D001706:Biopsy; D046508:Culture Techniques; D005753:Gastric Mucosa / Q000187:drug effects* / Q000473:pathology; D006801:Humans; D013276:Stomach Ulcer / Q000188:drug therapy* / Q000473:pathology; D013431:Sulfates / Q000494:pharmacology*; D013438:Sulfhydryl Compounds / Q000502:physiology*; D015032:Zinc / Q000494:pharmacology*; D019287:Zinc Sulfate
D013431:Sulfates; D013438:Sulfhydryl Compounds; D019287:Zinc Sulfate; D015032:Zinc; D000111:Acetylcysteine