[The topological characteristics of rat myocardial reactivity to noradrenaline, acetylcholine and a change in the electrostimulation frequency].
Dose-dependent effects of noradrenaline (10-7-10-6M), acetylcholine (10-8-3x10-6M) and stimulation rate (0.2-2.0 Hz) were obtained in experiments on myocardium preparations of the right and left atria and ventricles in rat. Three types of topological differences of the rat myocardium reactivity were observed: between the atria and ventricles (A/V), between the right and left atria and ventricles (R/L), between the right atrium (RA) and other cardiac chambers. A/V differences were most pronounced in the reactivity to acetylcholine (the atria were more reactive), the highest R/L differences were observed in the reactivity to noradrenaline (the myocardium of the right chambers was more reactive). RA reactivity greatly exceeded reactivity of other myocardial preparations to all three test influences. Topological peculiarities of chrono-inotropism permit supposing, that inotropic effects of rate changes in vivo are able to compensate, to some extent, the regional nonuniformity of cholin- and adrenergic regulatory inotropic effects.
Dudka
S B
SB
Kaz'min
S H
SH
D000109:Acetylcholine / Q000494:pharmacology*; D000818:Animals; D016275:Atrial Function; D004305:Dose-Response Relationship, Drug; D004558:Electric Stimulation / Q000379:methods; D006321:Heart / Q000187:drug effects* / Q000502:physiology; D006325:Heart Atria / Q000187:drug effects; D006339:Heart Rate / Q000187:drug effects / Q000502:physiology; D006352:Heart Ventricles / Q000187:drug effects; D066298:In Vitro Techniques; D008297:Male; D009200:Myocardial Contraction / Q000187:drug effects / Q000502:physiology; D009638:Norepinephrine / Q000494:pharmacology*; D051381:Rats; D016276:Ventricular Function
D000109:Acetylcholine; D009638:Norepinephrine
Topolohichni osoblyvosti reaktyvnosti miokarda shchuriv na noradrenalin, atsetylkholin ta zminu chastoty elektrostimuliatsiï.