Are perioperative nonsteroidal anti-inflammatory drugs ulcerogenic in the short term?
It is well documented that long term treatment with nonsteroidal anti-inflammatory drugs (NSAIDs) increases the risk of peptic ulcer and that gastroduodenal mucosal erosions can be demonstrated in volunteers within 1 week of treatment initiation. However, long term studies in nonsurgical patients have not documented gastroduodenal complications within the first week of treatment. Cumulative data from controlled studies of perioperative (> or = 48 hours and < or = 7 days) treatment with NSAIDs do not suggest an increased risk of gastroduodenal complications (such as bleeding/perforation) within this time frame. We conclude that the otherwise well documented gastrointestinal side effects of prolonged treatment with NSAIDs should not hinder short term NSAID treatment for improved analgesia after surgery.
Kehlet
H
H
Department of Surgical Gastroenterology, Hvidovre University Hospital, Denmark.
Dahl
J B
JB
D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage / Q000009:adverse effects*; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D005753:Gastric Mucosa / Q000187:drug effects; D006801:Humans; D010149:Postoperative Pain / Q000188:drug therapy*; D010437:Peptic Ulcer / Q000139:chemically induced*
D000894:Anti-Inflammatory Agents, Non-Steroidal