title: Plasma levels of mebendazole in children with hydatid disease.
abstract: The plasma levels of mebendazole in children with hydatid cyst disease were measured with high pressure liquid chromatography. In 24 children who received mebendazole orally in a dose of 50 mg/kg, the mean (SD) level 4 hours later was 25.76(9.81) ng/ml (87.6(33) nanomole/l). This result was similar to those in most adult series. During more prolonged treatment, the plasma level 4 hours after the dose of the drug rose significantly with respect to the initial level (p < 0.05).
authors.affiliation: Turkish Health and Therapy Foundation, Ankara.
authors.forename: M F
authors.initials: MF
authors.lastname: Toppare
authors.forename: A
authors.initials: A
authors.lastname: Gocmen
authors.forename: N
authors.initials: N
authors.lastname: Kiper
mesh_terms: D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D004444:Echinococcosis, Hepatic / Q000097:blood* / Q000188:drug therapy; D004445:Echinococcosis, Pulmonary / Q000097:blood* / Q000188:drug therapy; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D008463:Mebendazole / Q000097:blood* / Q000627:therapeutic use
chemical_list: D008463:Mebendazole