title: [Pulmonary surfactant in experimental congenital diaphragmatic hernia].
abstract: This paper examines the amounts of tensoactive phospholipids in the lung tissue of rat fetuses treated with Nitrofen (TOK) and in control animals. The herbicide led to congenital diaphragmatic hernia (CDH) in some fetuses and to pulmonary hypoplasia (PH) in all. The amounts of phosphatidylcholine (PC), phosphatidylglycerol (PG), phosphatidylinositol (PI) and phosphatidylethanolamine (PE) per gram of fresh lung tissue were significantly increased in comparison with the control animals, those of phosphatidylserine (PS) and sphingomyelin (SM) were also increased, but not significantly. Fetuses with HP alone had intermediate values. These findings are in agreement with our previous demonstration of an excess of type II pneumocytes in this model, and point to the existence of some trouble of the secretion or release of surfactant in it; although they do no clarify whether the amount of alveolar surfactant is in fact decreased.
authors.affiliation: Servicio de Cirugía Pediátrica, Hospital Na Sa de Aranzazu, San Sebastián.
authors.forename: L F
authors.initials: LF
authors.lastname: Alfonso
authors.forename: M
authors.initials: M
authors.lastname: Sasieta
authors.forename: N
authors.initials: N
authors.lastname: Ingunza
authors.forename: B
authors.initials: B
authors.lastname: López de Torre
authors.forename: P
authors.initials: P
authors.lastname: Aldazabal
authors.forename: F J
authors.initials: FJ
authors.lastname: Alvarez
authors.forename: J
authors.initials: J
authors.lastname: Vilanova
authors.forename: A
authors.initials: A
authors.lastname: Valls i Soler
authors.forename: J A
authors.initials: JA
authors.lastname: Tovar
mesh_terms: D000818:Animals; D005260:Female; D006548:Hernia, Diaphragmatic / Q000378:metabolism*; D065630:Hernias, Diaphragmatic, Congenital; D008168:Lung / Q000737:chemistry*; D010743:Phospholipids / Q000032:analysis* / Q000096:biosynthesis; D011663:Pulmonary Surfactants / Q000032:analysis* / Q000096:biosynthesis; D051381:Rats; D017208:Rats, Wistar
chemical_list: D010743:Phospholipids; D011663:Pulmonary Surfactants
vernacular_title: Surfactante pulmonar en la hernia diafragmatica congénita experimental.