title: [Herpes simplex virus infection in pregnancy: epidemiologic, diagnostic and therapeutic data. An unusual case of HSV-1 in monozygotic twins].
abstract: The Authors report a case of two pre-term monocorial twins affected by HSV-1 infection (Herpes Simplex Virus type 1), with generalized sepsis and involvement of the central nervous system (CNS), born by mother with primary infection who presented a typical vesicular eruption a week before delivery. As the HSV-1 was a disseminated type and the CNS was involved in both the twins, the diagnosis was based on clinical and laboratory findings (specific IgM and IgG) and on the use of Delpech-Lichtblau antibody liquoral index, a significant results both in the first and the second twin. Intensive care and early specific treatment with Acyclovir allowed a slow but progressive improvement of the twins' clinical picture. The antibody liquoral index may therapy of the viral sepsis cases involving the CNS, more than the cultural or antigen isolation of the treated virus.
authors.affiliation: Unità Operativa Pediatrico Neonatologica, Regione Abruzzo-ULSS n. 15-Vasto (Chieti), Presidio Ospedaliero.
authors.forename: G
authors.initials: G
authors.lastname: Parisi
authors.forename: N P
authors.initials: NP
authors.lastname: Squadrone
authors.forename: S
authors.initials: S
authors.lastname: Rojo
authors.forename: U
authors.initials: U
authors.lastname: Muzii
authors.forename: O
authors.initials: O
authors.lastname: Molino
authors.forename: A
authors.initials: A
authors.lastname: Chiarelli
mesh_terms: D000212:Acyclovir / Q000008:administration & dosage / Q000627:therapeutic use; D000328:Adult; D000906:Antibodies / Q000097:blood / Q000302:isolation & purification; D004200:Diseases in Twins / Q000175:diagnosis* / Q000453:epidemiology; D005260:Female; D006561:Herpes Simplex / Q000134:cerebrospinal fluid / Q000175:diagnosis* / Q000453:epidemiology; D006801:Humans; D007074:Immunoglobulin G / Q000032:analysis / Q000097:blood; D007075:Immunoglobulin M / Q000032:analysis / Q000097:blood; D007231:Infant, Newborn; D008297:Male; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000134:cerebrospinal fluid / Q000175:diagnosis* / Q000453:epidemiology; D014430:Twins, Monozygotic
chemical_list: D000906:Antibodies; D007074:Immunoglobulin G; D007075:Immunoglobulin M; D000212:Acyclovir
vernacular_title: L'infezione da herpes simplex virus in gravidanza: rilievi epidemiologici, diagnostici e terapeutici. A proposito di un caso insolito di HSV-1 in gemelli monocoriali.