Neurofibrillary degeneration and microtubule associated protein tau.
Alzheimer disease is characterized by neurofibrillary pathology containing paired helical filaments (PHF). These abnormal filaments consist of a modified form of microtubule associated protein tau. The modification involves phosphorylation. In this mini review, we summarize recent studies regarding the differences between normal tau and PHF-tau, focusing especially on the extent and the site of phosphorylation. We also discuss the mechanisms possible involved in the development of PHF.
Yen
S H
SH
Department of Pathology, Albert Einstein College of Medicine, Bronx New York.
Liu
W K
WK
D000544:Alzheimer Disease / Q000378:metabolism / Q000473:pathology; D000818:Animals; D006801:Humans; D008870:Microtubules / Q000502:physiology*; D009410:Nerve Degeneration / Q000502:physiology*; D016874:Neurofibrillary Tangles / Q000378:metabolism / Q000473:pathology; D009454:Neurofibrils / Q000502:physiology*; D010766:Phosphorylation; D016875:tau Proteins / Q000502:physiology*
D016875:tau Proteins