CD4 subsets in IgA nephropathy.
CD45RA+ (2H4+) and CD45RA-(CD29, 4B4+) antigenic expressions, recognized as a suppressor inducer and a helper inducer, respectively, on CD4+ and T alpha 4+ cells (Fc alpha receptor bearing CD4 T cells) were measured by three color flow cytometry in patients with IgA nephropathy (IgAN). The 4B4+ subsets of CD4 and T alpha 4 T cells were increased significantly in the patient group compared with the control group. The level of the 2H4+ subset did not differ between the two groups. No significant correlation was observed between the increase in the 4B4+ subset and disease severity, as estimated by measuring the proteinuria, levels of serum creatinine and immunoglobulins (Igs) or renal tissue damage. It was concluded that 4B4+ CD4+ and 4B4+ T alpha 4+ subsets might be involved in the mechanism of immunopathogenesis of IgA nephropathy.
Kashem
A
A
Division of Nephrology and Metabolism, Tokai University Department of Internal Medicine, Kanagawa, Japan.
Yamauchi
F
F
Yano
N
N
Miyazaki
M
M
Endoh
M
M
Nomoto
Y
Y
Sakai
H
H
D000328:Adult; D015703:Antigens, CD / Q000378:metabolism; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology*; D000939:Epitopes / Q000378:metabolism; D005260:Female; D005922:Glomerulonephritis, IGA / Q000097:blood / Q000209:etiology / Q000276:immunology*; D006801:Humans; D019012:Integrin beta1; D017493:Leukocyte Common Antigens / Q000378:metabolism; D008297:Male; D011961:Receptors, Fc / Q000378:metabolism; D016176:T-Lymphocyte Subsets / Q000276:immunology*
D015703:Antigens, CD; D000939:Epitopes; C036832:Fc(alpha) receptor; D019012:Integrin beta1; D011961:Receptors, Fc; D017493:Leukocyte Common Antigens