Inactivation of microbial contaminants of blood components.
Despite the low risk of transfusion-transmitted infection currently present in the blood supply, processes to inactivate contaminating viruses and bacteria may improve the safety of transfusion even further. A variety of techniques, using both physical and chemical processes, are being explored. Particularly promising is adaptation of the solvent/detergent technique (already in use for plasma derivatives) to plasma for transfusion. Inactivation of viruses in cellular components may require a combination of techniques, possibly including leukocyte depletion filtration, photoactive compounds, and subsequent washing. Concerns about potential toxicity of the agents employed and retention of component efficacy after treatment and storage remain unresolved, however.
AuBuchon
J P
JP
Department of Pathology, Dartmouth-Hitchcock Medical Center, Lebanon, New Hampshire.
Dodd
R Y
RY
D001419:Bacteria / Q000187:drug effects / Q000528:radiation effects; D001769:Blood / Q000382:microbiology*; D016913:Blood Component Transfusion; D003902:Detergents / Q000494:pharmacology; D004203:Disinfection / Q000379:methods*; D005374:Filtration; D006801:Humans; D008027:Light; D014780:Viruses / Q000187:drug effects / Q000528:radiation effects
D003902:Detergents