A family case of beta-thalassemia minor and hemoglobin Queens: alpha 34 (B15) Leu-Arg.
We report a Korean family case of beta-thalassemia minor and Hb Queens. This is the first case report of Hb Queens in Korea. A 43-year-old male and his four family members had beta-thalassemia minor which is very rare in Korea. Incidentally, an alpha chain variant with a high isoelectric point was also found in two other family members without clinical problems and was finally identified as alpha 34 (B15) Leu-Arg or Hemoglobin Queens.
Lee
N Y
NY
Department of Clinical Pathology, Seoul National University College of Medicine, Korea.
Cho
H I
HI
Kim
S I
SI
Kim
B K
BK
Ohba
Y
Y
Hattori
Y
Y
D000328:Adult; D001120:Arginine / Q000235:genetics; D005260:Female; D006455:Hemoglobins, Abnormal / Q000235:genetics*; D006801:Humans; D007723:Korea; D007930:Leucine / Q000235:genetics; D008297:Male; D010375:Pedigree; D017086:beta-Thalassemia / Q000097:blood / Q000235:genetics*
D006455:Hemoglobins, Abnormal; C035047:hemoglobin Queens; D001120:Arginine; D007930:Leucine