HLA-DQ beta chain can present mouse endogenous provirus MTV-9 product and clonally delete Tcr V beta 5+ and V beta 11+ T cells in transgenic mice.
The elusive Mls gene(s) are mouse mammary tumor virus genes. The endogenous cotolerogen involved in the clonal deletion of Tcr V beta 5.1, 5.2, and 11 in H-2E+ mouse strains has been narrowed down to MTV-9. We demonstrate that similar to H-2E alpha molecules, human DQw6 beta chain mediated clonal deletion of Tcr V beta 5.1, 5.2, and 11 also requires the MTV-9 gene product. This shows that human class II molecules can present mouse retroviral antigen. Further, backcross analysis involving [B10.M(DQb) x DBA/1] suggest a second cotolerogen in the B10.M background in the clonal deletion of V beta 5-bearing T cells.
Zhou
P
P
Department of Immunology, Mayo Clinic, Rochester, MN 55905.
Smart
M K
MK
Cheng
S
S
Savarirayan
S
S
Inoko
H
H
David
C S
CS
D000818:Animals; D000956:Antigens, Viral / Q000276:immunology*; D005814:Genes, Viral / Q000276:immunology; D006683:HLA-DQ Antigens / Q000276:immunology*; D006801:Humans; D007111:Immunity, Cellular / Q000276:immunology*; D007135:Immunoglobulin Variable Region / Q000276:immunology*; D007166:Immunosuppressive Agents / Q000276:immunology; D008324:Mammary Tumor Virus, Mouse / Q000276:immunology; D051379:Mice; D008811:Mice, Inbred DBA; D008822:Mice, Transgenic / Q000276:immunology; D009930:Organic Chemicals; D011533:Proviruses / Q000276:immunology; D016693:Receptors, Antigen, T-Cell, alpha-beta / Q000276:immunology*; D013601:T-Lymphocytes / Q000276:immunology*
D000956:Antigens, Viral; D006683:HLA-DQ Antigens; C063831:HLA-DQ6 antigen; D007135:Immunoglobulin Variable Region; D007166:Immunosuppressive Agents; D009930:Organic Chemicals; D016693:Receptors, Antigen, T-Cell, alpha-beta; C029248:Tolerogen