[Anti-M after transfusion as an indication of a genetic variant of the MN locus].
We report a case of an anti-M antibody (titer 128) and MN red blood cells (RBC) in a 76-year-old female German patient. In our case, however, RBC showed weak reactions to human anti-M compared with strong reactions using rabbit anti-M. Papain treatment destroyed the RBC reactivity to human anti-M whereas the strong reactivity to rabbit anti-M was unchanged. This pattern was also demonstrable in the patient's son and grandson. Our results indicate the existence of a rare allele at the MN locus in this family.
Heuft
H G
HG
Abteilung Innere Medizin, Freie Universität Berlin, Universitätsklinikum Rudolf Virchow, BRD.
Weisbach
V
V
Zeiler
T
T
Zimmermann
R
R
Zingsem
J
J
Eckstein
R
R
D000368:Aged; D001787:Blood Group Incompatibility / Q000097:blood / Q000175:diagnosis*; D001788:Blood Grouping and Crossmatching; D001803:Blood Transfusion; D002874:Chromosome Mapping; D005260:Female; D014644:Genetic Variation; D006801:Humans; D007519:Isoantigens / Q000032:analysis / Q000235:genetics*; D008951:MNSs Blood-Group System / Q000235:genetics* / Q000276:immunology; D010375:Pedigree; D010438:Peptic Ulcer Hemorrhage / Q000097:blood / Q000628:therapy*; D013276:Stomach Ulcer / Q000097:blood / Q000628:therapy*
D007519:Isoantigens; D008951:MNSs Blood-Group System
Anti-M nach Transfusion als Hinweis auf eine genetische Variante am MN-Locus.