[Cytofluorometric analysis of DNA content in proliferating cells of coronary arteriosclerotic lesions].
Cytofluorometric determination of DNA content was done on paraffin-embedded tissues of 19 cases of coronary arteriosclerotic lesions including fibrocellular intimal thickening lesions (FT) or atherosclerosis (AS). DNA distribution pattern of medial smooth muscle cells of coronary arteries with FT and AS was all diploid. The average proliferative index (PI) of both medial smooth muscle cells of coronary arteries with FT and AS was 4.8 +/- 0.6. DNA distribution patterns of intimal cells of coronary arteries with FT and AS were also diploid. The average PI of intimal cells of coronary arteries with FT and AS was 8.4 +/- 1.0 and 9.1 +/- 0.7, respectively. These results suggest that intimal cellular proliferation plays an important role in the development of atherosclerosis.
Kiyuna
M
M
Department of Clinical Laboratory Medicine, School of Medicine and Diagnostic Laboratory, University Hospital, University of Ryukyus, Okinawa.
Toda
T
T
Tamamoto
T
T
Shingaki
Y
Y
Shimajiri
S
S
Deguchi
S
S
Muto
Y
Y
D002455:Cell Division; D003324:Coronary Artery Disease / Q000378:metabolism / Q000473:pathology*; D003331:Coronary Vessels / Q000737:chemistry / Q000473:pathology*; D004247:DNA / Q000032:analysis*; D005260:Female; D005434:Flow Cytometry; D006801:Humans; D008297:Male; D008875:Middle Aged
D004247:DNA