[Progression after radical prostatectomy of cancer of the prostate: prognostic criteria and the role of PSA in monitoring].
Progression after radical prostatectomy, evaluated by a rise in plasma PSA and/or the appearance of a pelvic nodule positive on biopsy and/or the presence of bone metastases confirmed by bone scan, was studied in a series of patients with prostatic cancer with a follow-up of between 6 months and 5 years. The progression-free survival rate was 86% at 1 year and 60% at 5 years. A progression-free survival rate and the relative risk of progression were established on the basis of the morphological characteristics (anatomical stage, tumour volume, seminal vesicle invasion, condition of the prostatic capsule and lymph nodes, positive resection margins at the apex) and histological features (Gleason's score) of the cancer, allowing determination of the influence of prognostic criteria on the outcome. The positive resection margins at the apex were due to preservation of the nervi erigentes. The preservation of the neurovascular pedicles may not be justified in the case of a tumour confined to the prostatic apex.
Fendler
J P
JP
Service d'Urologie, Hôpital de l'Antiquaille, Lyon.
Dujardin
T
T
Bringeon
G
G
Adeleine
P
P
Devonec
M
M
Perrin
P
P
D000230:Adenocarcinoma / Q000097:blood / Q000473:pathology* / Q000556:secondary / Q000601:surgery*; D000368:Aged; D005500:Follow-Up Studies; D006801:Humans; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D009367:Neoplasm Staging; D010386:Pelvic Neoplasms / Q000556:secondary; D011379:Prognosis; D017430:Prostate-Specific Antigen / Q000097:blood*; D011468:Prostatectomy; D011471:Prostatic Neoplasms / Q000097:blood / Q000473:pathology* / Q000601:surgery*; D012307:Risk Factors; D015996:Survival Rate
D017430:Prostate-Specific Antigen
Progression après prostatectomie radicale pour cancer de la prostate: critères pronostiques et place du PSA dans la surveillance.