[A comparative study of the DNA structural damages and synthesis in embryos of the silkworm Bombyx mori irradiated with gamma rays at different developmental stages].
Studies have been made on formation and reparation of apurine-apyrimidine (AP) regions, monothread DNA ruptures, as well as on inhibition and recovery of DNA synthesis in gamma-irradiated 3- and 7-day embryos of the silkworm which sharply differ in their radiosensitivity. It was shown that in 3-day embryos, the number of AP regions and DNA ruptures immediately after irradiation is significantly higher than in 7-day embryos. DNA synthesis is more radiosensitive in 3-day embryos as compared to that in 7-day ones. Kinetics of postradiation recovery of regions and DNA ruptures in 3- and 7-day embryos is heterogeneous and significantly different. However, radiation inhibition and postradiation recovery of DNA synthesis in irradiated 3- and 7-day embryos are associated mainly with postradiation survival of these embryos.
Agaev
F A
FA
Gaziev
A I
AI
Zakrzhevskaia
D T
DT
Malakhova
L V
LV
Iusifov
N I
NI
D000818:Animals; D001080:Apurinic Acid / Q000528:radiation effects; D012831:Bombyx / Q000254:growth & development / Q000378:metabolism / Q000528:radiation effects*; D004249:DNA Damage; D004260:DNA Repair / Q000528:radiation effects; D004277:DNA, Single-Stranded / Q000096:biosynthesis* / Q000528:radiation effects*; D004625:Embryo, Nonmammalian; D005720:Gamma Rays; D011119:Polynucleotides / Q000528:radiation effects; D011836:Radiation Tolerance; D013997:Time Factors
D004277:DNA, Single-Stranded; D011119:Polynucleotides; C001790:apyrimidinic acid; D001080:Apurinic Acid
Sravnitel'noe issledovanie strukturnykh povrezhdeniĭ i sinteza DNK v émbrionakh tutovogo shelkopriada Bombyx mori, obluchennykh gamma-luchami na raznykh stadiiakh razvitiia.