title: Resuscitation fluids and oxygen transport in haemorrhagic shock.
abstract: This study examined the cardiovascular and oxygen transport/consumption relationships in haemorrhagic shock and resuscitation using Human Albumin and Gelatin solutions in a porcine haemorrhagic shock model. Immature pigs (17-25 kg) were anaesthetised and ventilated with nitrous oxide, oxygen and isoflurane. Aortic pressure monitoring and monitoring of pulmonary pressures and cardiac output via a Swan-Ganz catheter were instituted. A controlled haemorrhage of 40% of blood volume at 1% blood volume per minute was followed 30 minutes later by resuscitation with 60% of blood volume of 4.5% Human Albumin (Immuno) or 4% Modified Fluid Gelatin (Gelofusine). Haemorrhage caused marked decreases in (CI), mean arterial pressure and oxygen delivery (DO2). Oxygen consumption (V02) remained unchanged. Resuscitation with Albumin and Gelatin raised CI to values 60% to 70% above control though only Albumin restored DO2. Deterioration was more rapid in the Gelatin group due to the estimated half a life of 3 hours in this model. Oxygen extraction was 10% higher in the Gelatin group 2 hours after resuscitation. The role of oxygen radicals in haemorrhagic shock is discussed.
authors.affiliation: Northwestern Injury Research Centre, University of Manchester, U.K.
authors.forename: M Y
authors.initials: MY
authors.lastname: Rady
authors.forename: R A
authors.initials: RA
authors.lastname: Little
authors.forename: E
authors.initials: E
authors.lastname: Kirkman
authors.forename: N S
authors.initials: NS
authors.lastname: Faithfull
mesh_terms: D000418:Albumins; D000818:Animals; D004195:Disease Models, Animal; D005440:Fluid Therapy / Q000379:methods*; D005780:Gelatin; D006439:Hemodynamics; D010101:Oxygen Consumption; D011669:Pulmonary Wedge Pressure; D012151:Resuscitation / Q000379:methods; D012771:Shock, Hemorrhagic / Q000378:metabolism / Q000503:physiopathology / Q000628:therapy*; D012996:Solutions; D013552:Swine
chemical_list: D000418:Albumins; D012996:Solutions; D005780:Gelatin