[The effect of dalargin on stress-induced changes in the 5'-nucleotidase activity of the macrophages and in the level of endogenous blood cortisol in mice].
The action of dalargin, synthetic analogue of leuenkephaline, on stress-induced changes in 5'-nucleotidase activity and endogenous hydrocortisone levels was investigated in mice. It was found that there is a direct relation between the activity of 5'-nucleotidase and the level of hydrocortisone in CBA mice. For C57Bl/6 mice the relation was inverse. Dalargin is able to change the dependence from direct to opposite in CBA mice.
Kirillicheva
G B
GB
Mit'kin
V V
VV
Solov'eva
M S
MS
Zozulia
A A
AA
Shurin
M R
MR
Pshenichkin
S F
SF
Sukhikh
G T
GT
D015720:5'-Nucleotidase / Q000097:blood / Q000187:drug effects*; D000818:Animals; D004597:Electroshock / Q000009:adverse effects; D016308:Enkephalin, Leucine-2-Alanine / Q000031:analogs & derivatives* / Q000494:pharmacology; D006854:Hydrocortisone / Q000097:blood*; D008264:Macrophages / Q000187:drug effects* / Q000201:enzymology; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D013312:Stress, Physiological / Q000097:blood* / Q000209:etiology; D013997:Time Factors
D016308:Enkephalin, Leucine-2-Alanine; D015720:5'-Nucleotidase; C040996:enkephalin-Leu, Ala(2)-Arg(6)-; D006854:Hydrocortisone
Vliianie dalargina na stress-indutsirovannoe izmenenie aktivnosti 5'-nukleotidazy makrofagov i urovnia éndogennogo kortizola krovi mysheĭ.