title: Plasminogen activator in human tears.
abstract: Measurements were made of the nature and levels of plasminogen activator in human tears using, as a model of inflammation, patients undergoing cataract surgery. Tissue plasminogen activator (t-PA) but not urokinase plasminogen activator (u-PA) was found in tears. A wide variation in the range of t-PA in pre-operative tears was found. In those patients not receiving per-operative subconjunctival betamethasone a significant rise in t-PA was found in tears on the first post-operative day over pre-operative levels. A significant fall was noted in those receiving per-operative subconjunctival betamethasone.
authors.affiliation: Department of Ophthalmology, University of Oxford, UK.
authors.forename: J D
authors.initials: JD
authors.lastname: Stevens
authors.forename: J M
authors.initials: JM
authors.lastname: Marshall
authors.forename: L
authors.initials: L
authors.lastname: Benjamin
authors.forename: S A
authors.initials: SA
authors.lastname: Cederholm-Williams
authors.forename: A J
authors.initials: AJ
authors.lastname: Bron
mesh_terms: D001623:Betamethasone / Q000494:pharmacology; D002387:Cataract Extraction; D006801:Humans; D010960:Plasminogen Activators / Q000032:analysis* / Q000187:drug effects; D011184:Postoperative Period; D013666:Tears / Q000201:enzymology*; D010959:Tissue Plasminogen Activator / Q000032:analysis; D014568:Urokinase-Type Plasminogen Activator / Q000032:analysis
chemical_list: D001623:Betamethasone; D010960:Plasminogen Activators; D010959:Tissue Plasminogen Activator; D014568:Urokinase-Type Plasminogen Activator