Tissue distribution of MHC class II--positive cells, their down-manipulation by monoclonal antibodies and potential role in organ allograft immunogenicity.
This review article presents current state of knowledge of tissue distribution of MHC class II antigens in rat kidney. Our attention focuses particularly on down manipulation of these antigens by monoclonal antibodies. The results of organ perfusion procedure on prolongation of graft survival and perspectives of further studies are also discussed.
Krzymański
M
M
Department of Nephrology, Christian Albrechts University, Kiel, Germany.
Müller-Ruchholtz
W
W
D000818:Animals; D000911:Antibodies, Monoclonal / Q000494:pharmacology; D015536:Down-Regulation; D000949:Histocompatibility Antigens Class II / Q000378:metabolism*; D007165:Immunosuppression Therapy; D007668:Kidney / Q000276:immunology*; D016030:Kidney Transplantation / Q000276:immunology; D051381:Rats; D014018:Tissue Distribution; D014184:Transplantation, Homologous
D000911:Antibodies, Monoclonal; D000949:Histocompatibility Antigens Class II