title: Thrombosis in spinal cord injury.
abstract: Some traditional coagulation assays and several new molecular markers of hemostatic activation were measured in 37 patients with spinal cord injury (SCI). Twenty one of the patients (57%) developed deep vein thrombosis (DVT). The radiofibrinogen uptake test (RFUT) was used to diagnose DVT. Thirty eight percent of quadriplegic and 88% of paraplegic patients developed DVT (p < 0.005). No significant differences were found in platelet counts, mean platelet volumes, fibrinogen levels, von Willebrand factor (Ag) levels, platelet factor 4 and beta thromboglobulin concentrations between the groups with and without DVT. Fibrinopeptide A, thrombin/antithrombin III (TAT) complexes and plasma D-dimer levels were significantly higher in the patients with thrombosis. Most patients with DVT had elevated TAT complex levels up to three days before the RFUT became positive. D-dimer levels were highest after the diagnosis had been made.
authors.affiliation: Department of Neurosurgery, Niigata Brain Research Institute, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Fujii
authors.forename: E F
authors.initials: EF
authors.lastname: Mammen
authors.forename: A
authors.initials: A
authors.lastname: Farag
authors.forename: J
authors.initials: J
authors.lastname: Muz
authors.forename: G G
authors.initials: GG
authors.lastname: Salciccioli
authors.forename: S T
authors.initials: ST
authors.lastname: Weingarden
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000990:Antithrombin III / Q000032:analysis; D015415:Biomarkers / Q000097:blood; D005260:Female; D005338:Fibrin Fibrinogen Degradation Products / Q000032:analysis; D005344:Fibrinopeptide A / Q000032:analysis; D006801:Humans; D008297:Male; D008875:Middle Aged; D009097:Multienzyme Complexes / Q000032:analysis; D010264:Paraplegia / Q000097:blood; D010976:Platelet Count; D011782:Quadriplegia / Q000097:blood; D013119:Spinal Cord Injuries / Q000097:blood / Q000150:complications*; D013917:Thrombin / Q000032:analysis; D013918:Thrombin Time; D013927:Thrombosis / Q000097:blood / Q000209:etiology*
chemical_list: D015415:Biomarkers; D005338:Fibrin Fibrinogen Degradation Products; D009097:Multienzyme Complexes; D005344:Fibrinopeptide A; D000990:Antithrombin III; D013917:Thrombin