A study on conformationally restricted sangivamycins and their inhibitory abilities of protein kinases.
Conformational restrictions of sangivamycin, a rather selective inhibitor of PKC, could be achieved by the use of the steric effect and the gauche effect of the substituents on the ribofuranose moiety. The conformational deviations obtained by these methods were found to nicely correlate with the inhibitory ability of PKC.
Iimori
T
T
Faculty of Engineering, Yokohama National University, Japan.
Murai
Y
Y
Sugiyama
T
T
Shiroto
H
H
Ishizaki
T
T
Wakizaka
Y
Y
Kodama
Y
Y
Ohuchi
S
S
Ohtsuka
Y
Y
Oishi
T
T
D000900:Anti-Bacterial Agents / Q000737:chemistry* / Q000494:pharmacology; D009682:Magnetic Resonance Spectroscopy; D008968:Molecular Conformation; D011493:Protein Kinase C / Q000037:antagonists & inhibitors*; D011741:Pyrimidine Nucleosides / Q000737:chemistry* / Q000494:pharmacology
D000900:Anti-Bacterial Agents; D011741:Pyrimidine Nucleosides; C005699:sangivamycin; D011493:Protein Kinase C