MHC class II determinants on peripheral blood monocytes from newly diagnosed IDDM patients.
The expression of MHC class II determinants (HLA-DR, HLA-DP and Ia7) on peripheral blood monocytes (OKM1+ cells) was studied in 20 children with newly diagnosed IDDM. Monocytes of 10 children with IDDM and familial predisposition showed a statistically significant increase of HLA-DR expression when compared to control group (10 healthy children). There were no significant differences concerning Ia7 expression. HLA-DP expression was similar in all studied groups.
Pituch-Noworolska
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A
Department of Clinical Immunology, Polish-American Childrens Hospital, Karków.
Dziatkowiak
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H
Zembala
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M
D000293:Adolescent; D001323:Autoantibodies / Q000032:analysis; D001327:Autoimmune Diseases / Q000276:immunology*; D002648:Child; D003922:Diabetes Mellitus, Type 1 / Q000276:immunology*; D000939:Epitopes / Q000276:immunology; D006681:HLA-D Antigens / Q000032:analysis*; D006801:Humans; D007515:Islets of Langerhans / Q000276:immunology; D009000:Monocytes / Q000276:immunology*
D001323:Autoantibodies; D000939:Epitopes; D006681:HLA-D Antigens