title: Isolated severe thrombocytopenia and bleeding caused by piperacillin.
abstract: Bleeding and severe thrombocytopenia developed in a 71-year-old man who had been receiving piperacillin 5 g intravenously every 8 h for 9 days for the treatment of Pseudomonas aeruginosa septicemia. After piperacillin was discontinued, the platelet counts became normal. Rechallenge was made with 2 g of piperacillin intravenously resulting in thrombocytopenia within 6 h of piperacillin administration. The platelet count normalized after 3 days when no further piperacillin was given.
authors.affiliation: Department of Internal Medicine, St. Elizabeth Hospital Medical Center, Youngstown, Ohio 44501-1790.
authors.forename: E
authors.initials: E
authors.lastname: Olivera
authors.forename: P
authors.initials: P
authors.lastname: Lakhani
authors.forename: C
authors.initials: C
authors.lastname: Watanakunakorn
mesh_terms: D000368:Aged; D005884:Gingival Hemorrhage / Q000139:chemically induced*; D006801:Humans; D007275:Injections, Intravenous; D008297:Male; D008551:Melena / Q000139:chemically induced*; D010878:Piperacillin / Q000008:administration & dosage / Q000009:adverse effects*; D013921:Thrombocytopenia / Q000139:chemically induced*
chemical_list: D010878:Piperacillin