title: Primary structure and expression of the gamma 2 subunit of the glutamate receptor channel selective for kainate.
abstract: The presence and primary structure of a novel subunit of the mouse glutamate receptor channel, designated as gamma 2, have been revealed by cloning and sequencing the cDNA. The gamma 2 subunit has structural characteristics common to the neurotransmitter-gated ion channel family and shares a high amino acid sequence identity with the rat KA-1 subunit, thus constituting the gamma subfamily of the glutamate receptor channel. Expression of the gamma 2 subunit together with the beta 2 subunit in Xenopus oocytes yields functional glutamate receptor channels selective for kainate.
authors.affiliation: Department of Neuropharmacology, Brain Research Institute, Niigata University, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Sakimura
authors.forename: T
authors.initials: T
authors.lastname: Morita
authors.forename: E
authors.initials: E
authors.lastname: Kushiya
authors.forename: M
authors.initials: M
authors.lastname: Mishina
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D003001:Cloning, Molecular; D004247:DNA / Q000235:genetics / Q000302:isolation & purification; D005260:Female; D015870:Gene Expression / Q000235:genetics*; D007608:Kainic Acid / Q000378:metabolism*; D046911:Macromolecular Substances; D051379:Mice; D008969:Molecular Sequence Data; D009865:Oocytes / Q000378:metabolism / Q000502:physiology / Q000648:ultrastructure; D017470:Receptors, Glutamate; D017981:Receptors, Neurotransmitter / Q000737:chemistry / Q000235:genetics*; D012689:Sequence Homology, Nucleic Acid; D014982:Xenopus laevis
chemical_list: D046911:Macromolecular Substances; D017470:Receptors, Glutamate; D017981:Receptors, Neurotransmitter; D004247:DNA; D007608:Kainic Acid