title: Characterization of sulphoalkyl ether derivatives of beta-cyclodextrin by capillary electrophoresis with indirect UV detection.
abstract: A capillary electrophoresis method which characterizes the degrees of substitution of heterogeneous sulphoalkyl ether beta-cyclodextrin derivatives is described. The separation is based on the different electrophoretic mobilities observed from changes in the overall charge of the molecule as a result of substitution. Individual peaks of the electropherogram then provide a measure of each degree of substitution of the present beta-cyclodextrin. Detection of these beta-cyclodextrin derivatives is performed by indirect UV detection.
authors.affiliation: Center for Drug Delivery Research, University of Kansas, Lawrence 66045.
authors.forename: R J
authors.initials: RJ
authors.lastname: Tait
authors.forename: D J
authors.initials: DJ
authors.lastname: Skanchy
authors.forename: D P
authors.initials: DP
authors.lastname: Thompson
authors.forename: N C
authors.initials: NC
authors.lastname: Chetwyn
authors.forename: D A
authors.initials: DA
authors.lastname: Dunshee
authors.forename: R A
authors.initials: RA
authors.lastname: Rajewski
authors.forename: V J
authors.initials: VJ
authors.lastname: Stella
authors.forename: J F
authors.initials: JF
authors.lastname: Stobaugh
mesh_terms: D001565:Benzoates / Q000737:chemistry; D019817:Benzoic Acid; D003505:Cyclodextrins / Q000138:chemical synthesis* / Q000737:chemistry*; D004586:Electrophoresis; D013056:Spectrophotometry, Ultraviolet; D047392:beta-Cyclodextrins
chemical_list: D001565:Benzoates; D003505:Cyclodextrins; D047392:beta-Cyclodextrins; D019817:Benzoic Acid; C031215:betadex