title: Solid-phase syntheses of two deacetyl-thymosin alpha 1 analogues with substitution at position 21 and their effects on low E-rosette-forming lymphocytes of uremic patients.
abstract: Two deacetyl-thymosin alpha 1 analogues containing Phe or Phe(4F) at position 21 were synthesized by the manual solid-phase method and their immunological effects on the low E-rosette-forming lymphocytes of uremic patients were studied. Fluorination of the p-position of Phe21 resulted in a marked restorative effect on the low E-rosette-forming lymphocytes of uremic patients compared with that of [Phe21]deacetyl-thymosin alpha 1. The synthetic [Phe21]deacetyl-thymosin alpha 1 was approximately equal in potency to our synthetic deacetyl-thymosin alpha 1 in uremic patients.
authors.affiliation: Kidney Research Laboratory, Kojinkai, Sendia, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Abiko
authors.forename: H
authors.initials: H
authors.lastname: Sekino
mesh_terms: D000595:Amino Acid Sequence; D006801:Humans; D066298:In Vitro Techniques; D008214:Lymphocytes / Q000187:drug effects* / Q000276:immunology; D008969:Molecular Sequence Data; D012397:Rosette Formation; D013329:Structure-Activity Relationship; D000077596:Thymalfasin; D013947:Thymosin / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D014511:Uremia / Q000276:immunology*
chemical_list: D013947:Thymosin; D000077596:Thymalfasin