title: [Combined traditional Chinese and Western medicine in the treatment of intractable ulcer].
abstract: The curative effects of combined traditional Chinese and Western medicine in 508 patients of intractable peptic ulcer with gastroscopy confirmation were evaluated. The patients were divided into Chuanjia Weidan group (Group I, 260 patients) and cimetidine group (Group II, 248 patients). Debridement, injection and drug covering of ulcer surfaces were followed by oral Chinese medicine Chuanjia Weidan (50 g daily) or cimetidine (800 mg every night) for 4 weeks. In group I, 95.6% of patients with gastric ulcer were cured, while in group II, 87.2% with the same disease were cured. For the patients with duodenal ulcer in group I and group II, 88.2% and 85.2% were cured respectively (P > 0.05). 70% of the main symptoms were remitted in the first and 97% in the second week in group I, whereas in group II, the remission occurred in 33% and 64.5% respectively (P < 0.05). The clearance rate of Helicobacter pylori for gastric ulcer and duodenal ulcer in group I was 71.2% and 78.3% respectively, but 5.3% and 7.2% in group II (P < 0.01). Eighteen months after the treatment, 13% of the patients with gastric ulcer and 14.2% with duodenal ulcer in group I relapsed, while that of group II was 63% and 71.3% respectively (P < 0.01). The authors concluded that debridement, injection and drug covering of ulcer surface under the endoscopy associated with oral administration of Chinese medicine Chuanjia Weidan is efficacious in treating intractable peptic ulcer.
authors.affiliation: Institute of Gastroenterology, Linfen, Shanxi.
authors.forename: L S
authors.initials: LS
authors.lastname: Ma
authors.forename: T M
authors.initials: TM
authors.lastname: Guo
mesh_terms: D000287:Administration, Topical; D002927:Cimetidine / Q000627:therapeutic use*; D004359:Drug Therapy, Combination; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use*; D004381:Duodenal Ulcer / Q000188:drug therapy* / Q000382:microbiology; D005260:Female; D005773:Gastroscopy; D016481:Helicobacter Infections / Q000188:drug therapy; D016480:Helicobacter pylori / Q000187:drug effects; D006801:Humans; D008297:Male; D013276:Stomach Ulcer / Q000188:drug therapy* / Q000382:microbiology
chemical_list: D004365:Drugs, Chinese Herbal; D002927:Cimetidine