[The antidepressive properties of anaprilin].
After chronic administration of propranolol (1 and 5 mg/kg, 14 days) to rats time-course of forced swimming changed with the decrease of rhythmical index of depression. The drug attenuated depressogenic properties of reserpine and clonidine. Propranolol antidepressive activity is attributed to blockade cerebral adrenoreceptors.
Arushanian
E B
EB
Beĭer
E V
EV
D000818:Animals; D000928:Antidepressive Agents / Q000627:therapeutic use*; D003000:Clonidine / Q000494:pharmacology; D003863:Depression / Q000188:drug therapy / Q000209:etiology; D004195:Disease Models, Animal; D004305:Dose-Response Relationship, Drug; D004353:Drug Evaluation, Preclinical; D004347:Drug Interactions; D008297:Male; D011433:Propranolol / Q000627:therapeutic use*; D051381:Rats; D012110:Reserpine / Q000494:pharmacology; D013550:Swimming; D013997:Time Factors
D000928:Antidepressive Agents; D012110:Reserpine; D011433:Propranolol; D003000:Clonidine
Ob antidepressivnykh svoĭstvakh anaprilina.