The histopathological comparison of the results of the intra-arterial injections of propofol and thiopentone in rabbits.
The results of injections of propofol and thiopentone intra-arterially are compared in rabbits according to histopathological criteries. Thirteen New Zealand type rabbits are used. Two ml of 2.5% Thiopentone and 2 ml of 1% Propofol are administered to the rabbits under anesthesia. Three days after, their ears are amputated and sent to this pathological blind examination. In both groups, we saw neither a morphological change along the vessel walls nor significant bleeding. But between the groups there was a significant difference about oedema. Consequently, 2.5% thiopentone which is routinely used after intra-arterial administration, may be responsible of the gangrenous change but it is discussable and it makes significant oedema in animal models although propofol does not have this effect.
Babacan
A
A
Anaesthesiology Department, Gazi University, Medical Faculty, Ankara, Turkey.
Akçabay
M
M
Uluoğlu
O
O
Ozkoçak
I
I
Karadenizli
Y
Y
D000818:Animals; D004431:Ear, External / Q000187:drug effects* / Q000473:pathology; D007269:Injections, Intra-Arterial; D008297:Male; D015742:Propofol / Q000008:administration & dosage*; D011817:Rabbits; D013874:Thiopental / Q000008:administration & dosage*
D013874:Thiopental; D015742:Propofol