[Expression of HLA-DP antigens on normal and leukemic blood cells].
HLA-DP allodeterminant elicit weak cellular and humoral immune responses. This study was undertaken to find out if the low immunogenicity of HLA-DP could be accounted for by a low level of expression on peripheral blood mononuclear cells. Double staining experiments and flow cytometry were performed in 28 healthy individuals, HLA-DP was found to be as expressed as DR and DQ on B lymphocytes. Furthermore, a DP+/DR- lymphocyte sub-population was identified and characterized as freshly activated T lymphocytes.
Baudeau
C
C
DEA de Transplantation d'Organes et de Greffe de Tissus, Dijon-Besançon.
Falkenrodt
A
A
Tongio
M M
MM
D000328:Adult; D000368:Aged; D000911:Antibodies, Monoclonal / Q000276:immunology; D001402:B-Lymphocytes / Q000502:physiology*; D005260:Female; D005434:Flow Cytometry; D006682:HLA-DP Antigens / Q000276:immunology*; D006683:HLA-DQ Antigens / Q000276:immunology; D006801:Humans; D007938:Leukemia / Q000276:immunology*; D008297:Male; D008875:Middle Aged; D012016:Reference Values; D013601:T-Lymphocytes / Q000502:physiology*
D000911:Antibodies, Monoclonal; D006682:HLA-DP Antigens; D006683:HLA-DQ Antigens
Expression des antigènes HLA-DP sur les cellules sanguines normales et leucémiques.