title: Susceptibility of +/+, +/nu and nu/nu BALB/c mice to ocular herpes simplex virus infection.
abstract: Athymic (nude) mice have played an important role in defining the function of the immune system and its role in infectious diseases. In the majority of these studies, heterozygous +/nu mice have been used as normal controls for the nu/nu mice, and it has been assumed that +/nu mice have essentially normal immune systems. We have compared the response of +/+, +/nu and nu/nu BALB/c mice following ocular infection with HSV-1 and have found that +/nu mice develop significantly more severe blepharitis, vascularization of the cornea, stromal keratitis and extraocular disease (herpetiform spread) than +/+ BALB/c mice. The extraocular disease was particularly severe in the +/nu mice, suggesting that factors regulating herpetiform spread of the virus are deficient in these mice. Susceptibility to lethal encephalitis did not differ between +/+ and +/nu mice. These results suggest that significant differences exist in the response to ocular HSV infection between +/+ and +/nu mice.
authors.affiliation: Department of Ophthalmology, University of Wisconsin, Madison 53706.
authors.forename: C R
authors.initials: CR
authors.lastname: Brandt
mesh_terms: D000818:Animals; D001762:Blepharitis / Q000276:immunology; D016510:Corneal Neovascularization / Q000276:immunology; D004198:Disease Susceptibility; D016849:Keratitis, Herpetic / Q000276:immunology*; D051379:Mice; D008807:Mice, Inbred BALB C; D008819:Mice, Nude; D013045:Species Specificity