Effect of three months treatment with Ukrain on peripheral blood morphology in rodents.
Studies on Albino Swiss mice and Wistar rats have demonstrated that Ukrain administered intraperitoneally (i.p.) for three months produces the following effects in the haematologic parameters: increased leucocytes and decreased thrombocytes. The haemoglobin and erythrocyte levels, as well as haematocrit value, were unchanged. In the leucogram changes were observed; i.e., a fall in the number of neutrophil segments and an increase in the lymphocyte count. The erythrocyte indices, P.C.V., M.C.V., M.C.H. and M.C.H.C. were not changed by a period of three months i.p. Ukrain administration. The observed changes were more marked in female than in male animals and were greater in mice than in rats.
Jagiełło-Wójtowicz
E
E
Department of Pharmacology, Medical Academy, Lublin, Poland.
Kleinrok
Z
Z
Matuszek
B
B
Surmaczyńska
B
B
Baran
E
E
Nowicky
W
W
Nowicky
J W
JW
D000470:Alkaloids / Q000097:blood*; D000818:Animals; D001600:Berberine Alkaloids; D004906:Erythrocyte Count / Q000187:drug effects; D005260:Female; D006400:Hematocrit; D006454:Hemoglobins / Q000378:metabolism; D007958:Leukocyte Count / Q000187:drug effects; D008214:Lymphocytes / Q000187:drug effects; D008297:Male; D051379:Mice; D010617:Phenanthridines; D010976:Platelet Count / Q000187:drug effects; D051381:Rats; D017208:Rats, Wistar; D012727:Sex Characteristics; D013045:Species Specificity
D000470:Alkaloids; D001600:Berberine Alkaloids; D006454:Hemoglobins; D010617:Phenanthridines; C060921:ukrain