Stimulation of renal tubular transport of p-aminohippurate in rats of different ages by treatment with adrenocortical steroids.
Treatment with prednisolone or dexamethasone is followed by an increase in renal excretion of p-aminohippurate (PAH) and in accumulation of PAH in renal cortical slices, particularly in 5- and 10-day-old rats with immature kidney function. Treatment with triamcinolone is effective both in immature and in 55-day-old rats. There is no stimulation of PAH transport after treatment with mineralocorticoids (desoxycorticosterone, aldosterone).
Bräunlich
H
H
Institute of Pharmacology and Toxicology, Friedrich Schiller University, Jena, FRG.
Rassbach
H
H
Vogelsang
S
S
D000305:Adrenal Cortex Hormones / Q000494:pharmacology*; D000375:Aging / Q000378:metabolism*; D000818:Animals; D003907:Dexamethasone / Q000494:pharmacology; D005260:Female; D066298:In Vitro Techniques; D007672:Kidney Cortex / Q000378:metabolism; D007684:Kidney Tubules / Q000187:drug effects / Q000378:metabolism*; D008901:Mineralocorticoids / Q000494:pharmacology; D011239:Prednisolone / Q000494:pharmacology; D051381:Rats; D017208:Rats, Wistar; D013268:Stimulation, Chemical; D014221:Triamcinolone / Q000494:pharmacology; D010130:p-Aminohippuric Acid / Q000378:metabolism* / Q000652:urine
D000305:Adrenal Cortex Hormones; D008901:Mineralocorticoids; D014221:Triamcinolone; D003907:Dexamethasone; D011239:Prednisolone; D010130:p-Aminohippuric Acid