[Investigation of interleukin 2 receptor and T cell subsets in the patients with tuberculous meningitis].
Interleukin 2 receptor (IL-2R) on lymphocyte and T cell subsets of peripheral blood(PB), defined by monoclonal antibodies, were studied in 25 patients with tuberculous meningitis. 25 staff members served as PB control. Dynamic changes of IL-2R positive cells and T cell subsets were observed in 10 of 25 patients at sixth week after chemotherapy. IL-2R positive cells showed higher percentages in the patients than in healthy controls. Percentages of CD5and CD4cells were lower than those of healthy control. With chemotherapy, the percentages of CD4cells raised. The results indicated that M. tuberculosis might stimulate T cell to express IL-2R. A lower cell mediated immunity function in the patients with tuberculous meningitis was characterized by CD4 lymphopenia.
Zhang
S F
SF
Department of Respiration, Jinan Military General Hospital.
D000328:Adult; D016516:CD4-CD8 Ratio; D005260:Female; D006801:Humans; D008297:Male; D015375:Receptors, Interleukin-2 / Q000032:analysis*; D016176:T-Lymphocyte Subsets; D013601:T-Lymphocytes / Q000737:chemistry; D006377:T-Lymphocytes, Helper-Inducer; D014390:Tuberculosis, Meningeal / Q000276:immunology*
D015375:Receptors, Interleukin-2