[Observation of paired-pulse depression in CA1 region of hippocampal slices from coriaria lactone-kindled rats].
Paired-pulse depression (PPD) technique was used to investigate the potency of recurrent synaptic inhibition mediated by GABA in area CA1 of 54 hippocampal slices from coriaria lactone (CL)-kindled and control rats. When paired stimuli were sent to the axon of CA1 pyramidal cell and Schaffer collaterals, the effect of population spike PPD lasted about 40-60ms; no significant change was observed on PPD potency between kindled and control groups (P = 0.06, 2-way ANOVA). The results indicate that the GABA-ergic synaptic inhibition seemed not to play a key role in the maintenance of the chemical kindling induced by CL.
Guo
L
L
Chai
H
H
Xie
Y
Y
Liu
X
X
D000818:Animals; D004365:Drugs, Chinese Herbal / Q000494:pharmacology; D006624:Hippocampus / Q000503:physiopathology*; D066298:In Vitro Techniques; D007696:Kindling, Neurologic / Q000187:drug effects*; D007783:Lactones / Q000494:pharmacology*; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley; D013569:Synapses / Q000502:physiology; D005680:gamma-Aminobutyric Acid / Q000502:physiology
D004365:Drugs, Chinese Herbal; D007783:Lactones; D005680:gamma-Aminobutyric Acid; C049836:coriaria lactone