[An experimental study of gentamycin delivery into cornea and aqueous humor from the collagen corneal shield].
Collagen corneal shields immersed in 13.33 mg/ml gentamycin solution for 5 minutes were placed in rabbit eyes and the gentamycin concentrations in the cornea and aqueous humor were determined with radioimmunoassay. The results were compared with those achieved by soft contact lens, subconjunctival injection, and frequent instillations. It was found that (1) 1 and 3 hours after application, the collagen corneal shield produced significantly higher concentration of gentamycin in the aqueous than did the other methods, and in the cornea than did the contact lens or instillations; and (2) 6 hours after application, the antibiotic level in the cornea dropped lower than that by subconjunctival injection, but still 15-30 times higher than the bactericidal concentration.
Huang
Z P
ZP
Department of Ophthalmology, First Teaching Hospital, Beijing Medical University.
Wu
J A
JA
D000287:Administration, Topical; D000818:Animals; D001082:Aqueous Humor / Q000378:metabolism*; D003094:Collagen; D003263:Contact Lenses, Hydrophilic; D003315:Cornea / Q000378:metabolism*; D016503:Drug Delivery Systems; D005839:Gentamicins / Q000008:administration & dosage* / Q000493:pharmacokinetics; D008567:Membranes, Artificial; D011817:Rabbits
D005839:Gentamicins; D008567:Membranes, Artificial; D003094:Collagen