A cluster of dispensable genes within the human cytomegalovirus genome short component: IRS1, US1 through US5, and the US6 family.
By insertional mutagenesis, human cytomegalovirus recombinants deleted of each of the US6 glycoprotein family genes were isolated. A recombinant lacking IRS1, US1 through US5, and most of the US6 family was also isolated. The growth kinetics of these mutants were similar to that of the wild type. A dispensable cluster of genes was identified.
Jones
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Molecular Biology Section, American Cyanamid Co., Pearl River, New York 10965.
Muzithras
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D002478:Cells, Cultured; D003587:Cytomegalovirus / Q000235:genetics*; D005814:Genes, Viral; D006801:Humans; D005810:Multigene Family; D016254:Mutagenesis, Insertional; D009693:Nucleic Acid Hybridization; D015183:Restriction Mapping