Clinical trial of sulbactam/ampicillin in the treatment of typhoid fever, and in-vitro sensitivity of isolates to sulbactam/ampicillin and chloramphenicol.
A trial of Sulbactam/Ampicillin in treatment of typhoid fever was carried out while in-vitro sensitivity of the drug was compared with chloramphenicol. Sulbactam/Ampicillin was found to be effective in 11 out of 12 patients who received the drug. The 1 patient who failed to respond had intestinal perforation with peritonitis. No side effects were encountered. The in-vitro study showed that 91.7% of the isolates were sensitive to sulbactam/ampicillin compared to 75% sensitivity to chloramphenicol. The difference was however not statistically significant (P < 0.05). It is concluded that sulbactam/ampicillin is effective and safe in the treatment of typhoid infection.
Awotedu
A A
AA
Department of Medicine, University College Hospital, Ibadan.
Oyelese
A O
AO
Onadeko
B O
BO
D000293:Adolescent; D000328:Adult; D000667:Ampicillin / Q000494:pharmacology / Q000627:therapeutic use*; D002701:Chloramphenicol / Q000494:pharmacology*; D004359:Drug Therapy, Combination / Q000494:pharmacology / Q000627:therapeutic use; D005260:Female; D005335:Fever of Unknown Origin / Q000175:diagnosis; D006801:Humans; D008297:Male; D008826:Microbial Sensitivity Tests; D009549:Nigeria; D013407:Sulbactam / Q000494:pharmacology / Q000627:therapeutic use*; D014435:Typhoid Fever / Q000188:drug therapy*
C035444:sultamicillin; D002701:Chloramphenicol; D000667:Ampicillin; D013407:Sulbactam