title: Serum protein concentrations in Plasmodium falciparum malaria.
abstract: In patients with uncomplicated Plasmodium falciparum infection cytokine-mediated serum protein levels of C-reactive protein (CRP), coeruloplasmin (COE), beta 2-microglobulin (B2M), alpha 1-acid glycoprotein (AAG), alpha 1-antitrypsin (AAT), haptoglobin (HPT), prealbumin (PRE), retinol binding protein (RBP), albumin (ALB) and transferrin (TRF) were measured in an endemic area of the Amazonian rain forest. Semi-immune (SI) and nonimmune (NI) patients were investigated. In both patient groups the serum concentrations of CRP, COE and B2M were elevated on admission. In addition AAG and AAT concentrations were increased in NI patients compared to control subjects. Significantly lower serum concentrations of HPT, PRE, RBP, ALB and TRF were seen in both patient groups during the acute phase of the disease, and were more pronounced in NI patients. After a 28-day follow-up, AAT and B2M were normal in SI patients but HPT, AAT and B2M were still significantly altered in NI patients.
authors.affiliation: Department of Infectious Diseases and Chemotherapy, University of Vienna, Austria.
authors.forename: W
authors.initials: W
authors.lastname: Graninger
authors.forename: F
authors.initials: F
authors.lastname: Thalhammer
authors.forename: U
authors.initials: U
authors.lastname: Hollenstein
authors.forename: G M
authors.initials: GM
authors.lastname: Zotter
authors.forename: P G
authors.initials: PG
authors.lastname: Kremsner
mesh_terms: D000209:Acute-Phase Proteins / Q000032:analysis; D000293:Adolescent; D000328:Adult; D001798:Blood Proteins / Q000032:analysis*; D002981:Clindamycin / Q000627:therapeutic use; D005260:Female; D006801:Humans; D016778:Malaria, Falciparum / Q000097:blood* / Q000188:drug therapy / Q000276:immunology; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies
chemical_list: D000209:Acute-Phase Proteins; D001798:Blood Proteins; D002981:Clindamycin