[Differences in the dynamics of the eosinophilia, blood immunoglobulin E and the level of circulating immune complexes in patients with chronic opisthorchiasis treated with different doses of praziquantel].
Sixty patients with a chronic Opisthorchis felineus infection were administered one-day therapy with praziquantel in doses 25, 40, or 60-75 mg/kg b. m. The former two doses of the drug did not much improve the levels of the examined immunologic parameters. In patients treated with the highest dose of praziquantel a significant decrease of the total and specific IgE and CIC levels, reaching that in the reference groups, was observed in 6-8 months after the treatment, this indicating a 92% efficacy of the drug in this group of patients.
Legon'kov
Iu A
IuA
Ozeretskovskaia
N N
NN
Gervazieva
V B
VB
Ovsiannikova
I G
IG
Bronshteĭn
A M
AM
D000293:Adolescent; D000328:Adult; D000936:Antigen-Antibody Complex / Q000097:blood*; D002908:Chronic Disease; D004802:Eosinophilia / Q000097:blood*; D005243:Feces / Q000469:parasitology; D005260:Female; D006801:Humans; D007073:Immunoglobulin E / Q000097:blood*; D008297:Male; D008875:Middle Aged; D009889:Opisthorchiasis / Q000097:blood* / Q000188:drug therapy / Q000276:immunology / Q000469:parasitology; D010270:Parasite Egg Count; D011223:Praziquantel / Q000008:administration & dosage*
D000936:Antigen-Antibody Complex; D007073:Immunoglobulin E; D011223:Praziquantel
Razlichiia v dinamike éozinofilii krovi, immunoglobulinemii E i soderzhaniia tsirkuliruiushchikh immunnykh kompleksov u bol'nykh khronicheskim opistorkhozom, lechennykh raznymi dozami prazikvantelia.