[The antiepileptic effects of sodium valproate and the calcium antagonist riodipine when used jointly in a model of focal penicillin-induced epileptic activity].
In experiments on 52 freely moving Wistar male rats, 200-220 g in weight, on the model of focal penicillin-induced epileptic activity (EpA) in brain cortex the efficacy of combined application of drugs influencing different mechanisms of epileptogenesis: sodium valproate enhancing GABA-ergic processes, and the calcium antagonist ryodipine (1,4-dihydropyridine) have been studied. It was shown that valproate and ryodipine when used in combination at relatively small doses (150 and 0.8 mg/kg l.p., respectively) produced a more marked antiepileptic effect than each of these drugs given alone. These and previously reported results of studies on the model of generalized pentylenetetrazol-induced EpA, suggest that complex pathogenic therapy (CPT) as a combination of the antiepileptic drugs acting on the corresponding basic pathogenic mechanisms of respective form of epilepsy is reasonable to be used. CPT allows to obtain a better curative effect with a lower dose of each drug used and to reduce the risk of side effects of the drugs applied at large doses in case of monotherapy.
Kryzhanovskiĭ
G N
GN
Karpova
M N
MN
Abramova
E M
EM
Abrosimov
I Iu
IIu
D000818:Animals; D002121:Calcium Channel Blockers / Q000627:therapeutic use*; D004195:Disease Models, Animal; D004353:Drug Evaluation, Preclinical; D004357:Drug Synergism; D004359:Drug Therapy, Combination; D004569:Electroencephalography / Q000187:drug effects / Q000379:methods; D004828:Epilepsies, Partial / Q000139:chemically induced / Q000188:drug therapy*; D008297:Male; D009543:Nifedipine / Q000031:analogs & derivatives* / Q000627:therapeutic use; D010406:Penicillins; D051381:Rats; D017208:Rats, Wistar; D014635:Valproic Acid / Q000627:therapeutic use*
D002121:Calcium Channel Blockers; D010406:Penicillins; D014635:Valproic Acid; D009543:Nifedipine; C045912:ryodipine
Antiépilepticheskie éffekty val'proata natriia i antagonista kal'tsiia riodipina pri ikh sochetannom primenenii na modeli fokal'noĭ penitsillin-indutsirovannoĭ épileticheskoĭ aktivnosti.