[The effect increased choline levels on the synthesis and release of acetylcholine in heart atria in white rats].
The paper addresses the problem of (1) the relationship of choline in extracellular fluid and acetylcholine (ACh) synthesis in chambers of the heart of white rats, and (2) the possibility of physiological involvement of this ACh in the control of cardiac activity. Within 60 min after s.c. administration of choline in the dose of 300 mg/kg body weight the ACh content rose to 136% of the control value in isolated heart chambers and after administration of 400 mg/kg body weight to 159% of the control value. Increased ACh synthesis failed to affect the heart rate, nor did it increase the tonic effect of vagus innervation of the heart. Excessive ACh could however be released by electric transmural stimulation of isolated heart chambers as well as by potassium depolarization. The release depended on the presence of calcium ions. The obtained results demonstrate that an increase in the level of choline in extracellular fluid results in increased ACh synthesis in nerve terminals. Enhanced release of this ACh is a precondition for high choline levels to induce an increase in parasympathetic control of cardiac function.
Geiger
J
J
Katedra fyziologie lékarské fakulty University Karlovy v Plzni a Fyziologický ústav CSAV v Praze.
Stránský
P
P
Slavíková
J
J
Vlk
J
J
Rícný
J
J
Tucek
S
S
D000109:Acetylcholine / Q000378:metabolism*; D000818:Animals; D002794:Choline / Q000494:pharmacology*; D005260:Female; D006325:Heart Atria / Q000378:metabolism*; D006339:Heart Rate / Q000187:drug effects; D008297:Male; D051381:Rats
D002794:Choline; D000109:Acetylcholine
Vliv zvýsené hladiny cholinu na syntézu a uvolnování acetylcholinu v srdecních síních bílých potkanů.