title: Comparison between short- and long-term insulin-like growth factor response to recombinant human growth hormone.
abstract: Eight growth-hormone-deficient children were treated with recombinant human GH (rhGH). Results of the short-term metabolic response to rhGH performed at the start of therapy during a 5-day introduction period and long-term results on growth were analyzed. We could not find any correlation between the effects on the short-term metabolic test and the growth response during long-term therapy, namely between the urea and insulin-like growth factor-I response during the short test and the increase in growth velocity. The short-term test is not a good predictor of the long-term response.
authors.affiliation: Department of Pediatrics, University Canton Hospital of Geneva, Switzerland.
authors.forename: L A
authors.initials: LA
authors.lastname: Lopes
authors.forename: G E
authors.initials: GE
authors.lastname: Theintz
authors.forename: T
authors.initials: T
authors.lastname: Torresani
authors.forename: P C
authors.initials: PC
authors.lastname: Sizonenko
mesh_terms: D000293:Adolescent; D001806:Blood Urea Nitrogen; D001827:Body Height / Q000187:drug effects; D002648:Child; D002675:Child, Preschool; D005260:Female; D006128:Growth / Q000187:drug effects / Q000502:physiology; D013006:Growth Hormone / Q000172:deficiency / Q000627:therapeutic use*; D006801:Humans; D007334:Insulin-Like Growth Factor I / Q000378:metabolism*; D008297:Male; D011994:Recombinant Proteins / Q000627:therapeutic use; D013997:Time Factors
chemical_list: D011994:Recombinant Proteins; D007334:Insulin-Like Growth Factor I; D013006:Growth Hormone