A comparative study of the antitussive activity of levodropropizine and dropropizine in the citric acid-induced cough model in normal subjects.
Levodropropizine is the levo-rotatory (S)-enantiomer of dropropizine, a racemic non-opiate antitussive agent which has been used clinically for many years. Compared with the racemic drug, levodropropizine exhibits in animal models similar antitussive activity but considerably lower central nervous system (CNS) depressant effects. It is also less likely to cause sedation in treated patients. Since the comparative antitussive potency of the two drugs in clinical experimental models has not been evaluated, the authors performed a randomized, double blind, cross over investigation in which the effects of single oral doses (60 and 90 mg) of levodropropizine and dropropizine were assessed by using the citric acid-induced cough model in eight normal volunteers. Stimulation tests involved inhalation of individual cumulative doses of citric acid (6.3 to 53.3 mg) which at pre-study assessment had been found to induce reproducibly at least ten coughs over a 30 sec period. Each subject was studied by repeating the citric acid stimulation test four times (0 h, 1 h, 2 h and 6 h) on each of five different days separated by intervals of at least three days. In the absence of drug administration (control session), cough response to citric inhalation was remarkably reproducible throughout the 6 h period of observation. A marked and statistically significant reduction in cough response (to about one third--one sixth of the pre-drug values) was observed 1 h after intake for both compounds. At subsequent testing 2 h and 6 h after dosing, cough response was still depressed and did not differ significantly from that observed at 1 h.(ABSTRACT TRUNCATED AT 250 WORDS)
Fumagalli
G
G
Institute of Respiratory Pathophysiology, S. Donato Clinical Institute, S. Donato Milanese, Italy.
Cordaro
C I
CI
Vanasia
M
M
Balzarotti
C
C
Camusso
L
L
Caiazzo
G
G
Maghini
L
L
Mazzocchi
M
M
Zennaro
M
M
D000328:Adult; D000996:Antitussive Agents / Q000627:therapeutic use*; D002951:Citrates; D019343:Citric Acid; D003371:Cough / Q000139:chemically induced / Q000188:drug therapy* / Q000503:physiopathology; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D008168:Lung / Q000187:drug effects / Q000503:physiopathology; D008297:Male; D010349:Patient Compliance; D011409:Propylene Glycols / Q000627:therapeutic use*; D013237:Stereoisomerism
D000996:Antitussive Agents; D002951:Citrates; D011409:Propylene Glycols; D019343:Citric Acid; C035916:dipropizine