Behavior-related cortical activity and swim-to-platform performance in the aged rat.
Aged rats (26 months) usually retained normal acetylcholine-dependent and serotonin-dependent forms of neocortical low-voltage fast activity and serotonin-dependent hippocampal rhythmical slow-wave activity. In a simple swim-to-platform test, aged rats (23 and 26 months) performed normally in acquisition and in retention over a 7-day period. The results are discussed in relation to the common assumption that aged rats provide a valid model of human senile dementia.
Vanderwolf
C H
CH
Department of Psychology, University of Western Ontario, London, Canada.
D000109:Acetylcholine / Q000494:pharmacology; D000375:Aging / Q000523:psychology*; D000818:Animals; D001285:Atropine / Q000494:pharmacology; D001522:Behavior, Animal / Q000502:physiology*; D002540:Cerebral Cortex / Q000502:physiology*; D004567:Electrodes, Implanted; D004569:Electroencephalography / Q000187:drug effects; D004594:Electrophysiology; D006624:Hippocampus / Q000502:physiology; D011597:Psychomotor Performance / Q000502:physiology*; D051381:Rats; D012701:Serotonin / Q000494:pharmacology; D013550:Swimming
D012701:Serotonin; D001285:Atropine; D000109:Acetylcholine