Protective effect of Re-LPS antiserum on experimental multiple system organ failure.
This study examines the possible beneficial effect of Re-LPS (F515) antiserum on experimental multiple system organ failure (MSOF) in rabbits. The results showed that the plasma LPS level was significantly decreased, and it took a shorter period to clear up LPS in experimental than in control rabbits after receiving Re-LPS antiserum. Pretreatment with antiserum can markedly improve the function of the liver, lungs, kidneys, blood and gastrointestinal tract. The MSOF incidence in the group of rabbits receiving immune sera was only 11.2% and the survival rate was raised by about 40.0%. The results suggest that early passive immunotherapy may neutralize gut-derived endotoxin, inhibit endotoxin-induced mediators release and prevent development of severe complications due to sepsis. It is therefore postulated that LPS core antiserum may provide a prophylactic effect on the development of experimental MSOF.
Yao
Y M
YM
Trauma Research Center, Postgraduate Medical College, 304th PLA Hospital, Beijing.
Tian
H M
HM
Wang
Y P
YP
Sheng
Z Y
ZY
Shi
Z G
ZG
Xu
S H
SH
D000818:Animals; D000907:Antibodies, Bacterial; D004926:Escherichia coli / Q000276:immunology*; D005260:Female; D007106:Immune Sera; D007116:Immunization, Passive; D008070:Lipopolysaccharides / Q000276:immunology*; D008297:Male; D009102:Multiple Organ Failure / Q000209:etiology / Q000628:therapy*; D011817:Rabbits; D012771:Shock, Hemorrhagic / Q000150:complications / Q000382:microbiology
D000907:Antibodies, Bacterial; D007106:Immune Sera; D008070:Lipopolysaccharides