Reduction of postoperative adhesions in strabismus surgery.
An animal experiment was done to evaluate the efficacy of tissue coating with sodium hyaluronic acid and subconjunctival injection of triamcinolone acetate in reducing the severity of postoperative adhesions following strabismus surgery. Experimental animals underwent a mild traumatic surgical procedure in one superior rectus muscle and a severe traumatic surgical procedure in the other superior rectus muscle. Each group was divided into control group, sodium hyaluronate coating group and triamcinolone acetonide injection group. Grading the severity of adhesions through surgical exploration of operative sites and histological comparison after 4 weeks revealed a significant reduction of postoperative adhesions in sodium hyaluronate group compared with control group under conditions of severe surgical trauma. But triamcinolone groups have no significant differences compared with control groups by statistical analysis. Tissue protection afforded by sodium hyaluronate may lead to an effective method which minimizes the surgical trauma to the tissues and reduces the postsurgical adhesions following strabismus surgery.
Oh
S O
SO
Department of Ophthalmology, College of Medicine, Seoul National University, Korea.
Lee
J
J
D000818:Animals; D005128:Eye Diseases / Q000209:etiology / Q000517:prevention & control*; D006820:Hyaluronic Acid / Q000008:administration & dosage / Q000627:therapeutic use*; D007267:Injections; D009801:Oculomotor Muscles / Q000473:pathology; D011183:Postoperative Complications / Q000517:prevention & control; D011817:Rabbits; D013285:Strabismus / Q000601:surgery*; D000267:Tissue Adhesions / Q000517:prevention & control; D014222:Triamcinolone Acetonide / Q000008:administration & dosage / Q000627:therapeutic use; D014945:Wound Healing
D006820:Hyaluronic Acid; D014222:Triamcinolone Acetonide