Subcellular distribution of (+)-[3H]SKF 10,047 binding sites in rat liver.
The distribution of (+)-[3H]SKF 10,047 binding sites and the distribution of the established plasma membrane, nuclear, mitochondrial and endoplasmic reticulum markers in subcellular fractions of rat liver have been studied. The distribution profile of (+)-[3H]SKF 10,047 binding sites coincided with that of NADPH-cytochrome c reductase, the endoplasmic reticulum marker. (+)-[3H]SKF 10,047 binding sites in rat liver are therefore suggested to be located on the endoplasmic reticulum membrane and to represent a membrane-bound enzyme.
Samovilova
N N
NN
Preclinical Research Department, Joint Venture 'Constanta', Moscow, USSR.
Vinogradov
V A
VA
D000818:Animals; D001665:Binding Sites; D002462:Cell Membrane / Q000737:chemistry; D002467:Cell Nucleus / Q000737:chemistry; D004721:Endoplasmic Reticulum / Q000737:chemistry; D066298:In Vitro Techniques; D008099:Liver / Q000737:chemistry* / Q000648:ultrastructure; D008297:Male; D008930:Mitochondria, Liver / Q000737:chemistry; D009251:NADPH-Ferrihemoprotein Reductase / Q000032:analysis; D010620:Phenazocine / Q000031:analogs & derivatives* / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains; D011957:Receptors, Opioid / Q000032:analysis*; D017480:Receptors, sigma
D011957:Receptors, Opioid; D017480:Receptors, sigma; C012134:SK&F 10047; D009251:NADPH-Ferrihemoprotein Reductase; D010620:Phenazocine