[Hypoglycemic activity of bicyclic diterpenoids of the clerodane series as compared to adebit and maninil].
Biocyclic diterpenoids--salvin, salvicin and salvifolin, administered per os to rats at a dose of 50 mg/kg show marked hypoglycemic activity in intact animals as well as in animals with experimental hyperglycemia developing against a background of GTT (3000 mg/kg intraperitoneally) or alloxan (150 mg/kg subcutaneously). They are superior to adebit but inferior to maninil. Prophylactic and therapeutic administration of these compounds ensure the preservation of islet beta-cells in animals with alloxan diabetes.
Tashmukhamedova
M A
MA
Mukhina
O A
OA
Syrov
V N
VN
Khushbaktova
Z A
ZA
Katkova
S P
SP
Kosovskiĭ
M I
MI
D045784:Abietanes; D000284:Administration, Oral; D000818:Animals; D001643:Bridged Bicyclo Compounds / Q000627:therapeutic use; D002026:Buformin / Q000627:therapeutic use; D002336:Carnosine / Q000031:analogs & derivatives / Q000627:therapeutic use; D003921:Diabetes Mellitus, Experimental / Q000188:drug therapy*; D004224:Diterpenes / Q000494:pharmacology / Q000627:therapeutic use; D005905:Glyburide / Q000627:therapeutic use; D007004:Hypoglycemic Agents / Q000627:therapeutic use*; D008297:Male; D010936:Plant Extracts / Q000627:therapeutic use; D051381:Rats
D045784:Abietanes; D001643:Bridged Bicyclo Compounds; D004224:Diterpenes; D007004:Hypoglycemic Agents; D010936:Plant Extracts; C083003:salvicin; C077678:salvipholin; D002336:Carnosine; C018381:salvin; D005905:Glyburide; D002026:Buformin
Izuchenie gipoglikemicheskoĭ aktivnosti bitsiklicheskikh diterpenoidov klerodanovogo riada v sravnenii s adebitom i maninilom.