title: [In situ production of interferon gamma and interleukin 6 by infiltrating cells from human kidney allografts in irreversible rejection. Modulation by cytokines].
abstract: Using ELISPOT assays, we detected a significant number of cells secreting interferon-gamma and interleukin 6 among 8 irreversibly rejected kidney allografts compared with normal kidneys. Interleukin 2 increases the frequency of interferon-gamma producing cells and interleukin 4 decreases the frequency of both interferon-gamma and interleukin 6 producing cells.
authors.affiliation: Schering-Plough, Dardilly.
authors.forename: P
authors.initials: P
authors.lastname: Merville
authors.forename: C
authors.initials: C
authors.lastname: Pouteil-Noble
authors.forename: J
authors.initials: J
authors.lastname: Wijdenes
authors.forename: L
authors.initials: L
authors.lastname: Potaux
authors.forename: J L
authors.initials: JL
authors.lastname: Touraine
authors.forename: J
authors.initials: J
authors.lastname: Banchereau
mesh_terms: D003864:Depression, Chemical; D006084:Graft Rejection / Q000276:immunology*; D006801:Humans; D007371:Interferon-gamma / Q000096:biosynthesis*; D007376:Interleukin-2 / Q000494:pharmacology; D015847:Interleukin-4 / Q000494:pharmacology; D015850:Interleukin-6 / Q000096:biosynthesis*; D007668:Kidney / Q000187:drug effects / Q000378:metabolism*; D016030:Kidney Transplantation / Q000379:methods*; D013268:Stimulation, Chemical
chemical_list: D007376:Interleukin-2; D015850:Interleukin-6; D015847:Interleukin-4; D007371:Interferon-gamma
vernacular_title: Production in situ d'interféron gamma et d'interleukine 6 par les cellules infiltrant des allogreffes rénales humaines en rejet irréversible. Modulation par les cytokines.