title: MIC quality control guidelines for Haemophilus susceptibility tests using cefdinir (FK482), cefepime, cefetamet, cefpirome, ceftibuten, fleroxacin, temafloxacin, clarithromycin, RP59500, and trospectomycin.
abstract: A multilaboratory study was performed to establish broth microdilution MIC quality control (QC) guidelines for 10 investigational drugs which previously demonstrated significant activity against Haemophilus influenzae. MIC QC ranges for H. influenzae ATCC 49247 with Haemophilus test medium were determined by using multiple contemporary lots of Haemophilus test medium and the National Committee for Clinical Laboratory Standards' recommended numbers of replicate tests. On the basis of these results, QC ranges (generally modal MIC +/- one log2 dilution) are proposed for cefdinir, cefepime, cefetamet, cefpirome, ceftibuten, fleroxacin, temafloxacin, clarithromycin, RP59500, and trospectomycin. The proposed QC guidelines for clarithromycin and temafloxacin were recently accepted by the National Committee for Clinical Laboratory Standards.
authors.affiliation: Special Microbiology, University of Iowa, College of Medicine, Iowa City 52242.
authors.forename: M J
authors.initials: MJ
authors.lastname: Bale
authors.forename: R N
authors.initials: RN
authors.lastname: Jones
authors.forename: M E
authors.initials: ME
authors.lastname: Erwin
authors.forename: F P
authors.initials: FP
authors.lastname: Koontz
authors.forename: E H
authors.initials: EH
authors.lastname: Gerlach
authors.forename: P R
authors.initials: PR
authors.lastname: Murray
authors.forename: J A
authors.initials: JA
authors.lastname: Washington
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D000077525:Cefdinir; D000077722:Ceftibuten; D015296:Ceftizoxime / Q000031:analogs & derivatives / Q000494:pharmacology; D002511:Cephalosporins / Q000494:pharmacology; D017291:Clarithromycin; D004917:Erythromycin / Q000031:analogs & derivatives / Q000494:pharmacology; D016576:Fleroxacin / Q000494:pharmacology; D024841:Fluoroquinolones; D006190:Haemophilus / Q000187:drug effects*; D006801:Humans; D008826:Microbial Sensitivity Tests / Q000592:standards*; D011786:Quality Control; D015363:Quinolones / Q000494:pharmacology; D000198:Spectinomycin / Q000031:analogs & derivatives / Q000494:pharmacology; D014769:Virginiamycin / Q000494:pharmacology; D000097572:Cefpirome
chemical_list: D000900:Anti-Bacterial Agents; D000077525:Cefdinir; D000077722:Ceftibuten; D015296:Ceftizoxime; D002511:Cephalosporins; D017291:Clarithromycin; D004917:Erythromycin; D016576:Fleroxacin; D024841:Fluoroquinolones; D015363:Quinolones; D000198:Spectinomycin; D014769:Virginiamycin; D000097572:Cefpirome; C062940:quinupristin-dalfopristin; C054745:temafloxacin; C047444:cefetamet; C043267:trospectomycin