The Alzheimer's amyloid precursor is cleaved intracellularly in the trans-Golgi network or in a post-Golgi compartment.
Sambamurti
K
K
Department of Psychiatry, Mount Sinai School of Medicine, New York, New York 10029.
Refolo
L M
LM
Shioi
J
J
Pappolla
M A
MA
Robakis
N K
NK
D000544:Alzheimer Disease / Q000378:metabolism*; D053829:Amyloid Precursor Protein Secretases; D016564:Amyloid beta-Protein Precursor / Q000378:metabolism*; D000818:Animals; D007611:Aprotinin / Q000378:metabolism; D015153:Blotting, Western; D002352:Carrier Proteins / Q000378:metabolism; D002451:Cell Compartmentation; D010450:Endopeptidases / Q000378:metabolism; D006056:Golgi Apparatus / Q000378:metabolism*; D016716:PC12 Cells; D058255:Protease Nexins; D011956:Receptors, Cell Surface
D016564:Amyloid beta-Protein Precursor; D002352:Carrier Proteins; D058255:Protease Nexins; D011956:Receptors, Cell Surface; D007611:Aprotinin; D053829:Amyloid Precursor Protein Secretases; D010450:Endopeptidases