[Detection of G-T mutations at codon 12 of c-Ha-ras oncogenes in squamous cell carcinomas of the sinus maxillaris].
DNA extracted from paraffin-embedded minor carcinoma tissues of the sinus maxillaris, G-T mutations at codon 12 of c-Ha-ras oncogenes were detected with polymerase chain reaction and mutation-specific oligonucleotide probe hybridization, the mutations were identified in 5 out of 20 squamous cell carcinomas of the sinus maxillaris. This result indicated that c-Ha-ras oncogene is one of the genes associated with the development and progression of the squamous cell carcinomas of the sinus maxillaris, and G-T mutation may lead to activation of the c-Ha-ras oncogene.
Liu
X F
XF
Virus Research Institute, Hubei Medical College, Wuhan.
D001483:Base Sequence; D002294:Carcinoma, Squamous Cell / Q000235:genetics*; D003062:Codon / Q000235:genetics*; D015342:DNA Probes; D004273:DNA, Neoplasm / Q000235:genetics; D011905:Genes, ras / Q000235:genetics*; D006801:Humans; D008444:Maxillary Sinus Neoplasms / Q000235:genetics*; D008969:Molecular Sequence Data; D015345:Oligonucleotide Probes; D017354:Point Mutation; D016133:Polymerase Chain Reaction
D003062:Codon; D015342:DNA Probes; D004273:DNA, Neoplasm; D015345:Oligonucleotide Probes