[Anti-cardiolipin antibodies in Horton's disease].
A prospective study on 11 patients with temporal artery biopsy-proven arteritis examined the frequency and significance of anti-cardiolipin antibodies. Antibody levels in 7 patients were higher than 20 units but were not correlated with an inflammatory syndrome, as assessed by measurement of 4 inflammatory proteins (fibrinogen, C-reactive protein, orosomucoid and haptoglobin). These 7 patients were treated with steroids and their antibody levels returned to the normal range after 4 to 16 weeks of therapy, later than the inflammatory proteins. Two patients had slight increases of their anti-cardiolipin antibody levels, but no signs of clinical relapse or increases of inflammatory proteins were observed. In this study, no correlation was found between the presence of anti-cardiolipin antibodies and the occurrence of ischemic complications in 6 of the 11 patients.
Liozon
F
F
Service de Médecine Interne A, CHRU Dupuytren, Limoges.
Jauberteau-Marchan
M O
MO
Liozon
E
E
Vidal
E
E
D000368:Aged; D000369:Aged, 80 and over; D017153:Antibodies, Anticardiolipin / Q000032:analysis*; D001798:Blood Proteins / Q000378:metabolism; D005260:Female; D013700:Giant Cell Arteritis / Q000188:drug therapy / Q000276:immunology*; D006801:Humans; D007249:Inflammation / Q000097:blood; D008297:Male; D008775:Methylprednisolone / Q000627:therapeutic use; D011241:Prednisone / Q000627:therapeutic use; D011446:Prospective Studies; D013997:Time Factors
D017153:Antibodies, Anticardiolipin; D001798:Blood Proteins; D011241:Prednisone; D008775:Methylprednisolone
Les anticorps anti-cardiolipine dans la maladie de Horton.