title: Modulation of cerebral acetylcholine metabolism by the dorsal diencephalic conduction system in the rat.
abstract: We investigated the effects of interruption of the impulse flow in the habenulopeduncular pathways by local infusion of tetrodotoxin on the acetylcholine and choline content in selected dopamine rich regions in the forebrain and midbrain in rats. The tetrodotoxin infusion caused a marked increase in acetylcholine content in the medial frontal cortex, striatum and ventral tegmental area+interpenduncular nucleus, but not in the limbic area or the substantia nigra, whereas choline content was reduced only in both the striatum and ventral tegmental area+interpeduncular nucleus. There was an increase in 3,4-dihydroxyphenylacetic acid content in the striatum after the manipulation. These findings suggest that the dorsal diencephalic conduction system may be involved in the integration of the activity of cholinergic neurons in the forebrain and midbrain regions and striatal dopanine neurons may play a role in the modulation of cholinergic neurons.
authors.affiliation: Division of Mental Disorder Research, National Institute of Neuroscience, Tokyo, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Takashima
authors.forename: M
authors.initials: M
authors.lastname: Takita
authors.forename: A
authors.initials: A
authors.lastname: Umino
authors.forename: T
authors.initials: T
authors.lastname: Nishikawa
authors.forename: H
authors.initials: H
authors.lastname: Mitsushio
authors.forename: K
authors.initials: K
authors.lastname: Takahashi
mesh_terms: D000109:Acetylcholine / Q000378:metabolism*; D000818:Animals; D001921:Brain / Q000378:metabolism*; D002794:Choline / Q000378:metabolism; D003342:Corpus Striatum / Q000378:metabolism; D004027:Diencephalon / Q000187:drug effects / Q000502:physiology*; D004298:Dopamine / Q000378:metabolism; D008297:Male; D009431:Neural Conduction / Q000502:physiology*; D051381:Rats; D017208:Rats, Wistar; D013779:Tetrodotoxin / Q000494:pharmacology
chemical_list: D013779:Tetrodotoxin; D002794:Choline; D000109:Acetylcholine; D004298:Dopamine