Interaction between ethanol and diltiazem in the model of barium arrhythmia in the rat.
The antiarrhythmic action of diltiazem in the model of barium arrhythmia was studied in rats non-dependent and dependent on ethanol. The results of our studies showed that single intragastric administration of ethanol jointly with diltiazem did not significantly attenuate the antiarrhythmic effect of diltiazem. Ethanol administered repeatedly and jointly with diltiazem influenced the antiarrhythmic action of diltiazem in different ways, depending on the used dose of diltiazem. After repeated joint administration of ethanol and diltiazem in a lower dose, attenuation of the antiarrhythmic effect of diltiazem was not observed. Repeated joint administration of ethanol and diltiazem in a higher dose attenuated the antiarrhythmic effect of diltiazem. Those experiments also showed that single administration of diltiazem did not significantly influence the ethanol level in the blood; however, when administered repeatedly, diltiazem reduced the concentration of ethanol in blood.
Filipek
B
B
Department of Pharmacodynamics, Medical Academy, Kraków, Poland.
Krupińska
J
J
Szymańska
I
I
Zebala
K
K
Librowski
T
T
Piekoszewski
W
W
D000437:Alcoholism / Q000150:complications; D000818:Animals; D001145:Arrhythmias, Cardiac / Q000139:chemically induced / Q000150:complications / Q000188:drug therapy*; D001464:Barium; D017609:Barium Compounds; D002712:Chlorides; D004110:Diltiazem / Q000494:pharmacology / Q000627:therapeutic use*; D004195:Disease Models, Animal; D004305:Dose-Response Relationship, Drug; D004347:Drug Interactions; D004562:Electrocardiography / Q000187:drug effects; D000431:Ethanol / Q000097:blood / Q000633:toxicity*; D008297:Male; D051381:Rats
D017609:Barium Compounds; D002712:Chlorides; C024986:barium chloride; D001464:Barium; D000431:Ethanol; D004110:Diltiazem