title: Effects of neonatal removal of superior cervical ganglion on serotonin and thyrotropin-releasing hormone immunoreactivity in the intermediolateral cell column of the rat spinal cord.
abstract: In this study, we investigated the effects of the neonatal removal of the right superior cervical ganglion on the serotonin-like and thyrotropin-releasing-hormone-like immunoreactivities (5-HT-LI and TRH-LI) in the intermediolateral cell column (IML) of the spinal cord by quantitative image analysis. Two weeks after the lesion, we observed a 60% reduction in 5-HT-LI, while TRH-LI was not significantly reduced, in the right IML (lesioned side) at T1-2 levels. One month after the lesion, 5-HT-LI and TRH-LI were significantly reduced by 60% in the right IML at T1-2 levels. After 3 months, this decrease persisted at this level. In addition, we observed a 30% loss of the 5-HT-LI in the right IML at T3-4 levels, whereas TRH-LI did not decrease significantly at T3-4 levels. These findings are discussed and compared with those of other experimental studies on serotonergic reorganization in the rat spinal cord.
authors.affiliation: INSERM U-336, Development Plasticity and Aging of the Nervous System, Montpellier, France.
authors.forename: P
authors.initials: P
authors.lastname: Poulat
authors.forename: L
authors.initials: L
authors.lastname: Marlier
authors.forename: F
authors.initials: F
authors.lastname: Pellas
authors.forename: N
authors.initials: N
authors.lastname: Rajaofetra
authors.forename: A
authors.initials: A
authors.lastname: Privat
mesh_terms: D000375:Aging / Q000502:physiology; D000818:Animals; D000831:Animals, Newborn / Q000502:physiology*; D005260:Female; D005728:Ganglia, Sympathetic / Q000166:cytology / Q000502:physiology*; D006651:Histocytochemistry; D006735:Horseradish Peroxidase; D007091:Image Processing, Computer-Assisted; D008297:Male; D051381:Rats; D012701:Serotonin / Q000276:immunology / Q000378:metabolism*; D013116:Spinal Cord / Q000033:anatomy & histology / Q000276:immunology / Q000378:metabolism*; D013973:Thyrotropin-Releasing Hormone / Q000276:immunology / Q000378:metabolism*
chemical_list: D012701:Serotonin; D013973:Thyrotropin-Releasing Hormone; D006735:Horseradish Peroxidase