Female sex hormone, estradiol, antagonizes the immunosuppressive activity of cyclosporine in rat organ transplantation.
Hirasawa
K
K
Department of Experimental Surgery, National Children's Medical Research Centre, Tokyo, Japan.
Kamada
N
N
D000818:Animals; D016572:Cyclosporine / Q000037:antagonists & inhibitors* / Q000494:pharmacology; D004958:Estradiol / Q000031:analogs & derivatives* / Q000494:pharmacology; D004966:Estrogens, Conjugated (USP) / Q000494:pharmacology; D006084:Graft Rejection / Q000187:drug effects*; D006085:Graft Survival / Q000187:drug effects*; D016027:Heart Transplantation / Q000276:immunology*; D007165:Immunosuppression Therapy / Q000379:methods; D016031:Liver Transplantation / Q000276:immunology*; D008297:Male; D011336:Probability; D051381:Rats; D011919:Rats, Inbred Strains; D016038:Skin Transplantation / Q000276:immunology*
D004966:Estrogens, Conjugated (USP); D004958:Estradiol; D016572:Cyclosporine