[Permselect--a new substance for leukocyte elimination].
Permselect particles consisting of purified plant cell wall ghosts obtained from the biomass of a suspension culture of Chenopodium album L. show a very high efficiency for leukocyte binding. A package containing 1 g dry Permselect eliminates 99-100% of leukocytes from 80 ml of fresh blood, preserved whole blood, or red blood cell concentrates. At comparable conditions Permselect shows a higher efficiency of leukocyte binding than commercial filter material (cotton, cellulose acetate). The vitality parameter of filtered erythrocytes and their stability during storage were not altered. The data are discussed with respect to causality of leukocyte binding to the pectin-containing surface of the cell wall particles.
Mavrina
L
L
Institut für Transfusionsmedizin der Medizinischen Fakultät (Charité), Humboldt-Universität, Berlin, BRD.
Matthes
G
G
Ehwald
R
R
D000327:Adsorption; D016913:Blood Component Transfusion / Q000295:instrumentation*; D001803:Blood Transfusion / Q000295:instrumentation*; D002473:Cell Wall; D002482:Cellulose; D005434:Flow Cytometry; D006801:Humans; D007937:Leukapheresis / Q000295:instrumentation*; D007958:Leukocyte Count; D008212:Lymphocyte Depletion / Q000295:instrumentation*; D010368:Pectins; D010976:Platelet Count; D014462:Ultrafiltration / Q000295:instrumentation*
D010368:Pectins; D002482:Cellulose
Permselect--ein neues Material für die Leukozytenelimination.