Frequency of common colds and serum levels of sICAM-1 (CD54), sLFA-3 (CD58) and sIL-2R (CD25).
Epidemiologic case-control studies have suggested an inverse relationship between past medical history of frequency of common colds and subsequent cancer risk for various sites. One hypothetical explanation for this finding may be that there are unknown differences in immune responsiveness between patients developing cancer and healthy individuals. The present study examines the relationship between the frequency of common colds and a) plasma levels of sICAM-1/CD54, sLFA-3/CD58 and sIL-2R/CD25 which are believed to modulate activation of immune responses, and b) cell-mediated immunity in vivo as determined by Multitest Mérieux. The investigation was conducted as a correlation study amongst a healthy group of individuals from the general population in Germany. We found a statistically significant inverse relationship between frequency of common colds and levels of sCD58 and, partially, sCD54. No association was found between levels of sCD25 and results of Multitest Mérieux.
Becker
N
N
German Cancer Research Center, Department of Epidemiology, Heidelberg.
Abel
U
U
Stiepak
C
C
Meuer
S C
SC
D000368:Aged; D015703:Antigens, CD / Q000097:blood*; D018968:CD58 Antigens; D015815:Cell Adhesion Molecules / Q000097:blood*; D003139:Common Cold / Q000453:epidemiology / Q000276:immunology*; D005260:Female; D006801:Humans; D007111:Immunity, Cellular; D018799:Intercellular Adhesion Molecule-1; D008297:Male; D008562:Membrane Glycoproteins / Q000097:blood*; D008875:Middle Aged; D009369:Neoplasms / Q000453:epidemiology / Q000276:immunology; D015375:Receptors, Interleukin-2 / Q000378:metabolism*; D012307:Risk Factors; D012995:Solubility
D015703:Antigens, CD; D018968:CD58 Antigens; D015815:Cell Adhesion Molecules; D008562:Membrane Glycoproteins; D015375:Receptors, Interleukin-2; D018799:Intercellular Adhesion Molecule-1