title: Definition of a small chromosomal rearrangement on chromosome 11p14 by molecular cytogenetics in situ hybridization.
abstract: Chromosomal in situ hybridization allows the detection and the definition of single copy DNA segments of very small size. In a particular case, we demonstrate the inactivity of this molecular cytogenetic technique. In this case, karyotype analysis revealed a chromosome 11p+. In situ hybridization of probes PBGD, D11S29, NCAM, and ETSI located at 11q23-qter shows that the extra chromosomal material on chromosome 11p+ is a duplication of the 11q23-qter region.
authors.affiliation: Department of Human Genetics, Laval Medical Center, Ste-Foy, Quebec.
authors.forename: D
authors.initials: D
authors.lastname: Bérubé
authors.forename: R
authors.initials: R
authors.lastname: Gagné
mesh_terms: D000015:Abnormalities, Multiple / Q000235:genetics; D002648:Child; D002871:Chromosome Banding; D002880:Chromosomes, Human, Pair 11 / Q000502:physiology*; D015321:Gene Rearrangement / Q000502:physiology*; D006801:Humans; D017403:In Situ Hybridization; D007621:Karyotyping