title: [Evaluation of the efficacy of antimicrobial drugs in ophthalmic solutions].
abstract: The antimicrobial efficacy of preservatives in ophthalmic solutions was tested. Five strains were used as challenge organisms. They represented bacteria, yeasts and molds. Sixty per cent of the ophthalmic solutions showed a good preservation against S. aureus ATCC 6538, according to the standards and in 40% of cases, the bacteria disappeared on the second week. Against E. coli ATCC 8739, 90% of the samples were well preserved and in 10% the bacteria disappeared by the second week. Against Ps. aeruginosa ATCC 9027, C. Albicans ATCC 10231 and Asp. niger ATCC 16404, the ophthalmic solutions showed a 100% preservation. The majority of the products showed a satisfactory preservation. They contained declared preservatives and sometimes combinations of two antimicrobial agents.
authors.affiliation: Université d'Athènes, Faculté de Médecine, Laboratoire de Microbiologie, Grèce.
authors.forename: C
authors.initials: C
authors.lastname: Economou-Stamatelopoulou
authors.forename: J
authors.initials: J
authors.lastname: Papavassiliou
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents; D001419:Bacteria / Q000187:drug effects; D004341:Drug Evaluation; D005658:Fungi / Q000187:drug effects; D009883:Ophthalmic Solutions / Q000494:pharmacology*
chemical_list: D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents; D009883:Ophthalmic Solutions
vernacular_title: Evaluation de l'efficacité des agents antimicrobiens dans les solutions ophtalmiques.