Protective effect of ascorbic acid in high altitude hypoxia in the rat.
Control (physiological saline treated) and ascorbic acid (AA) treated (1 mg.g-1 b.w. one hour before exposure) 18-day-old rats were exposed for 1 hour to high altitude in a hypobaric chamber and the mean lethal altitudes were calculated. AA displayed a protective effect, so that in two identical experiments the mean lethal altitude was 10,900 and 10,150 m in controls, while it was 11,500 and 11,450 m in AA treated animals.
Schreiber
M
M
Institute of Physiology, First Faculty of Medicine, Charles University, Prague.
D000532:Altitude Sickness / Q000401:mortality / Q000517:prevention & control*; D000818:Animals; D001205:Ascorbic Acid / Q000494:pharmacology*; D051381:Rats
D001205:Ascorbic Acid