The fms-like tyrosine kinase, a receptor for vascular endothelial growth factor.
The fms-like tyrosine kinase (Flt) is a transmembrane receptor in the tyrosine kinase family. Expression of flt complementary DNA in COS cells conferred specific, high-affinity binding of vascular endothelial growth factor, also known as vascular permeability factor (VEGF-VPF), a factor that induces vascular permeability when injected in the guinea pig skin and stimulates endothelial cell proliferation. Expression of Flt in Xenopus laevis oocytes caused the oocytes to release calcium in response to VEGF-VPF. These findings show that flt encodes a receptor for VEGF-VPF.
de Vries
C
C
Department of Medicine, University of California, San Francisco 94143.
Escobedo
J A
JA
Ueno
H
H
Houck
K
K
Ferrara
N
N
Williams
L T
LT
D000818:Animals; D003001:Cloning, Molecular; D003432:Cross-Linking Reagents; D016228:Endothelial Growth Factors / Q000502:physiology*; D004789:Enzyme Activation; D006801:Humans; D066298:In Vitro Techniques; D008222:Lymphokines / Q000502:physiology*; D011518:Proto-Oncogene Proteins / Q000235:genetics / Q000502:physiology*; D011956:Receptors, Cell Surface / Q000235:genetics*; D015398:Signal Transduction; D014162:Transfection; D042461:Vascular Endothelial Growth Factor A; D040281:Vascular Endothelial Growth Factor Receptor-1; D042442:Vascular Endothelial Growth Factors; D014982:Xenopus laevis
D003432:Cross-Linking Reagents; D016228:Endothelial Growth Factors; D008222:Lymphokines; D011518:Proto-Oncogene Proteins; D011956:Receptors, Cell Surface; D042461:Vascular Endothelial Growth Factor A; D042442:Vascular Endothelial Growth Factors; D040281:Vascular Endothelial Growth Factor Receptor-1