Germ cell neoplasms in three intersex patients with 46,XY karyotype.
This report presents 3 cases with gonadoblastoma mixed with other germ cell tumours in intersex patients, all with a 46,XY karyotype. One 11-year-old patient was a true hermaphrodite, the others, aged 13 and 18, respectively, had both gonadal dysgenesis. Different clinical courses have been noted. Two patients had gonadoblastoma combined with dysgerminoma; in one of them a teratoma was also found. In the third case gonadoblastoma was transformed into teratocarcinoma. The malignant degeneration was more serious in the 2 pubertal patients. Thus, we recommend early and prophylactic gonadectomy.
Petersen
L
L
Department of Urology, Odense University Hospital, Denmark.
Kock
K
K
Jacobsen
B B
BB
D000293:Adolescent; D002648:Child; D012734:Disorders of Sex Development / Q000150:complications*; D004407:Dysgerminoma / Q000150:complications* / Q000473:pathology; D005260:Female; D006061:Gonadal Dysgenesis, 46,XY / Q000150:complications*; D006801:Humans; D008297:Male; D010053:Ovary / Q000002:abnormalities*; D013724:Teratoma / Q000150:complications* / Q000473:pathology; D013737:Testis / Q000002:abnormalities*