[Interleukin 4 increases lymphocytic adhesion to allogenic endothelium through a dependent protein kinase A].
Interleukin 4 and tumor necrosis factor alpha increase endothelial cell adhesiveness for lymphocytes by promoting adhesion molecules synthesis. We have shown that intracellular mechanisms, which transduce IL 4--but not TNF alpha--signal, involve a protein kinase A.
Galéa
P
P
Laboratoire d'Immunologie clinique, CHU, Tours.
Lebranchu
Y
Y
D002448:Cell Adhesion / Q000187:drug effects; D015815:Cell Adhesion Molecules / Q000378:metabolism; D004730:Endothelium, Vascular / Q000187:drug effects*; D006801:Humans; D066298:In Vitro Techniques; D015847:Interleukin-4 / Q000494:pharmacology*; D008214:Lymphocytes / Q000187:drug effects*; D011494:Protein Kinases / Q000378:metabolism*; D013268:Stimulation, Chemical; D014409:Tumor Necrosis Factor-alpha / Q000494:pharmacology; D014471:Umbilical Veins / Q000187:drug effects*
D015815:Cell Adhesion Molecules; D014409:Tumor Necrosis Factor-alpha; D015847:Interleukin-4; D011494:Protein Kinases
L'interleukine 4 augmente l'adhésion lymphocytaire à l'endothélium allogénique par une voie protéine kinase A dépendante.