title: Genetic evidence for a novel familial Alzheimer's disease locus on chromosome 14.
abstract: Familial Alzheimer's disease (FAD) has been shown to be genetically heterogeneous, with a very small proportion of early onset pedigrees being associated with mutations in the amyloid precursor protein (APP) gene on chromosome 21, and some late onset pedigrees showing associations with markers on chromosome 19. We now provide evidence for a major early onset FAD locus on the long arm of chromosome 14 near the markers D14S43 and D14S53 (multipoint lod score z = 23.4) and suggest that the inheritance of FAD may be more complex than had initially been suspected.
authors.affiliation: Dept. of Medicine, University of Toronto, Ontario, Canada.
authors.forename: P
authors.initials: P
authors.lastname: St George-Hyslop
authors.forename: J
authors.initials: J
authors.lastname: Haines
authors.forename: E
authors.initials: E
authors.lastname: Rogaev
authors.forename: M
authors.initials: M
authors.lastname: Mortilla
authors.forename: G
authors.initials: G
authors.lastname: Vaula
authors.forename: M
authors.initials: M
authors.lastname: Pericak-Vance
authors.forename: J F
authors.initials: JF
authors.lastname: Foncin
authors.forename: M
authors.initials: M
authors.lastname: Montesi
authors.forename: A
authors.initials: A
authors.lastname: Bruni
authors.forename: S
authors.initials: S
authors.lastname: Sorbi
authors.forename: I
authors.initials: I
authors.lastname: Rainero
authors.forename: L
authors.initials: L
authors.lastname: Pinessi
authors.forename: D
authors.initials: D
authors.lastname: Pollen
authors.forename: R
authors.initials: R
authors.lastname: Polinsky
authors.forename: L
authors.initials: L
authors.lastname: Nee
authors.forename: J
authors.initials: J
authors.lastname: Kennedy
authors.forename: F
authors.initials: F
authors.lastname: Macciardi
authors.forename: E
authors.initials: E
authors.lastname: Rogaeva
authors.forename: Y
authors.initials: Y
authors.lastname: Liang
authors.forename: N
authors.initials: N
authors.lastname: Alexandrova
authors.forename: W
authors.initials: W
authors.lastname: Lukiw
authors.forename: K
authors.initials: K
authors.lastname: Schlumpf
authors.forename: R
authors.initials: R
authors.lastname: Tanzi
authors.forename: T
authors.initials: T
authors.lastname: Tsuda
authors.forename: L
authors.initials: L
authors.lastname: Farrer
authors.forename: J M
authors.initials: JM
authors.lastname: Cantu
authors.forename: R
authors.initials: R
authors.lastname: Duara
authors.forename: L
authors.initials: L
authors.lastname: Amaducci
authors.forename: L
authors.initials: L
authors.lastname: Bergamini
authors.forename: J
authors.initials: J
authors.lastname: Gusella
authors.forename: A
authors.initials: A
authors.lastname: Roses
authors.forename: D
authors.initials: D
authors.lastname: Crapper McLachlan
mesh_terms: D000368:Aged; D000483:Alleles; D000544:Alzheimer Disease / Q000235:genetics*; D016564:Amyloid beta-Protein Precursor / Q000235:genetics; D001483:Base Sequence; D002874:Chromosome Mapping; D002883:Chromosomes, Human, Pair 14; D004247:DNA / Q000235:genetics; D005260:Female; D005819:Genetic Markers; D006801:Humans; D008126:Lod Score; D008297:Male; D008875:Middle Aged; D008969:Molecular Sequence Data; D010375:Pedigree
chemical_list: D016564:Amyloid beta-Protein Precursor; D005819:Genetic Markers; D004247:DNA