Inflammatory signs, antibody response and antigen detection in cerebrospinal fluid over the course of neuroborreliosis.
CSF and serum specimens were consecutively obtained from three patients with neuroborreliosis (stage I, II and III), CSF protein content, cell counts and differential, IgG index, oligoclonal bands and anti-B. burgdorferi antibodies were measured. Cerebrospinal fluid (CSF) was tested for Borrelia-DNA being present prior to and after antibiotic treatment. While DNA could be identified before ceftriaxone was administered, there were no more amplification products afterwards. The goal of this study was to compare the usefulness of serodiagnostic methods and the detection of Borrelia burgdorferi-DNA in patients with clinically confirmed neuroborreliosis to test the efficiency of antibiotic therapy.
Lange
R
R
Humboldt Universität, Charité, Zentrum für Nervenheilkunde, Berlin, Germany.
Bocklage
H
H
Karch
H
H
Kölmel
H W
HW
D000368:Aged; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D000907:Antibodies, Bacterial / Q000097:blood / Q000134:cerebrospinal fluid*; D000942:Antigens, Bacterial / Q000302:isolation & purification; D001483:Base Sequence; D015748:Borrelia burgdorferi Group / Q000235:genetics / Q000276:immunology*; D004269:DNA, Bacterial / Q000134:cerebrospinal fluid / Q000235:genetics; D005260:Female; D006801:Humans; D007249:Inflammation / Q000276:immunology; D008193:Lyme Disease / Q000175:diagnosis / Q000188:drug therapy / Q000276:immunology*; D008875:Middle Aged; D008969:Molecular Sequence Data; D009422:Nervous System Diseases / Q000175:diagnosis / Q000188:drug therapy / Q000276:immunology*; D016133:Polymerase Chain Reaction
D000900:Anti-Bacterial Agents; D000907:Antibodies, Bacterial; D000942:Antigens, Bacterial; D004269:DNA, Bacterial