Characterization of aeroallergen-induced dyspnea in unrestrained guinea pigs by bias-flow-ventilated whole body plethysmography.
Aeroallergen-induced dyspnea in guinea pigs was associated with an increase in amplitude in the box pressure fluctuations (212%) and pseudo-flow signal (604%) and an 80% decline (from 0.19 to 0.04 s) in relaxation time (the time it takes the box pressure signal to drop from its peak to 1/3 of its peak value). All of these lung dysfunction changes were highly significant (P < 0.001). Pyrilamine (1 mg/kg, p.o., -2 h) inhibited dyspnea (delta P and delta F) by 50-53%. This technique allows quantitative analysis of allergic dyspnea in conscious, unrestrained guinea pigs.
Chand
N
N
Wallace Laboratories, Division of Carter-Wallace Inc., Cranbury, NJ 08512.
Nolan
K
K
Pillar
J
J
Zomask
M
M
Diamantis
W
W
Sofia
R D
RD
D000336:Aerosols; D000485:Allergens / Q000008:administration & dosage / Q000276:immunology*; D000818:Animals; D004417:Dyspnea / Q000276:immunology* / Q000503:physiopathology; D006168:Guinea Pigs; D008297:Male; D010047:Ovalbumin / Q000008:administration & dosage / Q000276:immunology; D010993:Plethysmography, Whole Body; D011738:Pyrilamine / Q000494:pharmacology; D012129:Respiratory Function Tests
D000336:Aerosols; D000485:Allergens; D010047:Ovalbumin; D011738:Pyrilamine