title: Efficacy of diethylcarbamazine medicated salt in interrupting Brugia malayi transmission in hill tribe settlements in Kerala State.
abstract: A filariasis survey carried out about eight years after achieving zero microfilaria (mf) rates following administration of diethylcarbamazine (DEC) medicated salt in the Kani hill tribe settlements in Quilon and Thiruvananthapuram districts of Kerala State revealed that there was no reappearance of Brugia malayi infection in the experimental areas. Mf rates were maintained at zero level in the experimental villages, while in the control villages, 2.9 per cent mf positives were observed. Mansonia (Mansonioides) uniformis dissected did not reveal filarial infection. It is concluded that DEC medicated salt regime in the experimental areas of Kani hill tribe settlements has been successful in effectively interrupting B. malayi transmission. Pilot studies in other B. malayi endemic areas of India using DEC medicated salt regime with the objective of eliminating B. malayi transmission are advocated, since the parasite has a restricted distribution in India and is already showing a declining trend.
authors.affiliation: National Institute of Communicable Diseases, Sham Nath Marg, Delhi.
authors.forename: S M
authors.initials: SM
authors.lastname: Kaul
authors.forename: V K
authors.initials: VK
authors.lastname: Raina
authors.forename: R D
authors.initials: RD
authors.lastname: Joshi
authors.forename: C N
authors.initials: CN
authors.lastname: Koya
authors.forename: A
authors.initials: A
authors.lastname: Kumar
authors.forename: T
authors.initials: T
authors.lastname: Verghese
mesh_terms: D000818:Animals; D000852:Anopheles / Q000469:parasitology; D017178:Brugia malayi / Q000302:isolation & purification; D003465:Culex / Q000469:parasitology; D004049:Diethylcarbamazine / Q000008:administration & dosage / Q000627:therapeutic use*; D005368:Filariasis / Q000469:parasitology / Q000517:prevention & control* / Q000635:transmission; D006801:Humans; D007194:India; D012982:Sodium, Dietary; D013045:Species Specificity
chemical_list: D012982:Sodium, Dietary; D004049:Diethylcarbamazine