The relationship between systolic blood pressure and microvascular resistance in non-diabetic and diabetic subjects.
Skin blood flow and microvascular resistance were measured in the feet of hypertensive and normotensive subjects by the non-invasive transient thermal clearance method. Skin blood flow decreased and microvascular resistance increased as a function of systolic brachial blood pressure for the non-diabetic subjects who were not treated by vasoactive medication. The relationship between blood flow and systolic blood pressure for diabetic patients and for patients who were treated by enalapril was poor. The average resistance for non-diabetic patients treated by enalapril was lower than that of untreated non-diabetic subjects. For diabetic patients no significant difference in resistance between enalapril treated and untreated patients was found. The results demonstrate that for non-diabetic patients the role of microvascular resistance in hypertension is significant while it is less important in diabetic patients.
Nitzan
M
M
Department of Applied Physics and Electro-Optics, Jerusalem College of Technology, Israel.
Glikberg
F
F
Fidel
J
J
Gross
C
C
Bar-On
H
H
Mahler
Y
Y
D000328:Adult; D000368:Aged; D000375:Aging / Q000502:physiology; D001794:Blood Pressure / Q000187:drug effects / Q000502:physiology*; D003920:Diabetes Mellitus / Q000188:drug therapy / Q000503:physiopathology*; D004656:Enalapril / Q000494:pharmacology; D005260:Female; D006801:Humans; D008297:Male; D008833:Microcirculation / Q000187:drug effects / Q000502:physiology; D008875:Middle Aged; D012039:Regional Blood Flow / Q000187:drug effects / Q000502:physiology; D012867:Skin / Q000098:blood supply; D014655:Vascular Resistance / Q000187:drug effects / Q000502:physiology*
D004656:Enalapril