[The clinico-genetic aspects of mental retardation related to the fragile-X chromosome].
This review deals with main problems of syndrome of X-fragile chromosome. The history of discovery and subsequent study of diseases as well as methods of examination, main clinical symptoms, methods of treatment and prophylaxis have been described. Some hypotheses, explaining complicated mechanism of fra-X syndrome inheritance are discussed. The recent achievements of molecular and genetic investigations of mental backwardness, associated with X-fragile chromosome are included in review.
Viekhova
N V
NV
Demydova
I A
IA
Bychkova
H M
HM
Vorsanova
S H
SH
Buzhiievs'ka
T I
TI
D002873:Chromosome Fragility; D004247:DNA / Q000235:genetics; D003878:Dermatoglyphics; D005600:Fragile X Syndrome / Q000150:complications / Q000175:diagnosis / Q000235:genetics*; D006801:Humans; D008607:Intellectual Disability / Q000175:diagnosis / Q000209:etiology / Q000235:genetics*; D011599:Psychopathology; D014960:X Chromosome / Q000648:ultrastructure
D004247:DNA
Kliniko-henetychni aspekty rozumovoï vidstalosti, zv'iazanoï z lamkoiu X-khromosomoiu.