title: Determinants of plasma ascorbic acid in a healthy male population.
abstract: The antioxidant properties of vitamin C may be involved in the prevention of cancer. The correlation between dietary vitamin C intake as estimated by a dietary questionnaire and plasma ascorbic acid (AA) was examined in 68 nonsmoking male volunteers aged 30-59 years. Determinants of plasma AA as well as interrelationships between various antioxidants in plasma were also explored. The determinants of plasma AA were examined by a multiple regression model containing dietary vitamin C, calories, body weight, and amount of beverages consumed. Higher vitamin C intake (P < 0.0002) increased plasma AA, while greater body weight (P < 0.005) decreased plasma AA. A significant correlation (r = 0.43; P < 0.0003) between vitamin C intake and plasma AA was observed. There was a negative correlation between plasma AA and plasma uric acid (r = -0.32; P < 0.007) and positive associations between plasma beta-carotene and plasma alpha-tocopherol (r = 0.39; P < 0.001) and between plasma beta-carotene and plasma glutathione peroxidase (r = 0.32; P < 0.008). Vitamin C supplement users had higher plasma AA compared to nonusers. The relationship between plasma AA and vitamin C intake appears to be curvilinear with the non-supplement users at the linear part of the curve and the supplement users at the plateau. Plasma AA is an appropriate biomarker, in our subjects, of dietary vitamin C except for people consuming large amounts of this vitamin either in their diet or in supplemental form.
authors.affiliation: Division of Cancer Prevention and Control, National Cancer Institute, Bethesda, Maryland 20892.
authors.forename: R
authors.initials: R
authors.lastname: Sinha
authors.forename: G
authors.initials: G
authors.lastname: Block
authors.forename: P R
authors.initials: PR
authors.lastname: Taylor
mesh_terms: D000328:Adult; D000975:Antioxidants / Q000032:analysis; D001205:Ascorbic Acid / Q000008:administration & dosage / Q000097:blood*; D001628:Beverages; D001823:Body Composition; D001835:Body Weight; D002338:Carotenoids / Q000097:blood; D003683:Dehydroascorbic Acid; D002149:Energy Intake; D005979:Glutathione Peroxidase / Q000097:blood; D006801:Humans; D008019:Life Style; D008297:Male; D008875:Middle Aged; D009043:Motor Activity; D012044:Regression Analysis; D014527:Uric Acid / Q000097:blood; D014810:Vitamin E / Q000097:blood; D019207:beta Carotene
chemical_list: D000975:Antioxidants; D019207:beta Carotene; D014810:Vitamin E; D014527:Uric Acid; D002338:Carotenoids; D005979:Glutathione Peroxidase; D001205:Ascorbic Acid; D003683:Dehydroascorbic Acid