[Insulin-like growth factor I in patients with newly detected insulin-dependent diabetes mellitus].
Levels of insulin-like growth factor 1 (IGF-1) or somatomedin C were investigated in 12 subjects with only the onset (3-18 mos.) of IDDM. These levels were low as compared to control values (213 + 65 and 450 + 40 ng/ml) and vice versa, growth hormones levels were higher than those in control subjects (14.0 + 8.0 and 7.5 + 1.2 ng/ml). In one month after intensified insulin infusion and three daily injections, the ratio is smoothed (IGF-1 -- 320 + 20 during CSII; 280 + 12 ng/ml during conventional insulin therapy and GH -- 10.0 + 1.2 for CSII and 15.0 + 1.7 ng/ml for CIT). The disturbed GH/IGF-1 ratio correlated with the glycemia level (r = 0.65). A close connection was established between the levels of IGF-1 and C-peptide concentrations in patients with IDDM onset (r = 0.70, p < 0.05), making it possible to influence beta-cell proliferation and to maintain DM remission.
Shishko
P I
PI
Sadykova
R E
RE
Kovalev
P A
PA
Goncharov
B V
BV
D000293:Adolescent; D000328:Adult; D002096:C-Peptide / Q000097:blood; D003922:Diabetes Mellitus, Type 1 / Q000097:blood*; D005260:Female; D013006:Growth Hormone / Q000097:blood; D006801:Humans; D007328:Insulin / Q000008:administration & dosage; D007334:Insulin-Like Growth Factor I / Q000378:metabolism*; D007515:Islets of Langerhans / Q000503:physiopathology; D008297:Male
D002096:C-Peptide; D007328:Insulin; D007334:Insulin-Like Growth Factor I; D013006:Growth Hormone
Insulinopodobnyĭ faktor rosta 1 u bol'nykh s vpervye vyiavlennym insulinzavisimym sakharnym diabetom.