title: Intracerebroventricular LHRH may serve as a discriminative stimulus in male rats.
abstract: Male Wistar rats (N = 16) were trained to discriminate 5 micrograms/kg LHRH, injected intraperitoneally, from saline in a two-lever, food-reinforced drug discrimination procedure, with an injection-session interval of 45 min. Reliable discrimination of LHRH was acquired within 60 training sessions. Subsequent generalization tests in brain-cannulated animals showed dose-dependent and time-related partial substitution of intracerebroventricular LHRH for intraperitoneal LHRH (ventricle doses ranged from 25-400 ng, and the injection-session intervals ranged from 10-40 min). These results indicate that centrally administered LHRH may serve as a dose- and time-dependent discriminative stimulus in male rats.
authors.affiliation: Netherlands Institute for Brian Research, Amsterdam.
authors.forename: R
authors.initials: R
authors.lastname: de Beun
authors.forename: E
authors.initials: E
authors.lastname: Jansen
authors.forename: R P
authors.initials: RP
authors.lastname: Heinsbroek
authors.forename: J L
authors.initials: JL
authors.lastname: Slangen
authors.forename: N E
authors.initials: NE
authors.lastname: van de Poll
mesh_terms: D000818:Animals; D001921:Brain / Q000187:drug effects*; D003214:Conditioning, Classical / Q000187:drug effects*; D004193:Discrimination Learning / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D005793:Generalization, Psychological / Q000187:drug effects; D007987:Gonadotropin-Releasing Hormone / Q000494:pharmacology*; D007274:Injections, Intraperitoneal; D007276:Injections, Intraventricular; D008297:Male; D051381:Rats; D017208:Rats, Wistar
chemical_list: D007987:Gonadotropin-Releasing Hormone