title: [The nonspecific mechanisms of the pharmacological correction of motoneuron trophic failure in experimental botulin poisoning].
abstract: Cobalamines, leukovorine, cymidine phosphocholine, dalargin are pharmacological agents that affect the support of motoneuronal trophic functions, unlike the actoprotector bemityl, prevent the development of fatal botulinic intoxication, but have no effects on the specific mechanisms of botulinic damage when the threshold concentrations of toxin achieve target cells. The depotentiating effect of the drugs is associated with the increased natural degradation of botulinic toxin in its target cells.
authors.forename: V V
authors.initials: VV
authors.lastname: Mikhaĭlov
authors.forename: V V
authors.initials: VV
authors.lastname: Mikhaĭlov
mesh_terms: D000208:Acute Disease; D000818:Animals; D000931:Antidotes / Q000627:therapeutic use*; D001905:Botulinum Toxins / Q000506:poisoning*; D002794:Choline / Q000378:metabolism; D004353:Drug Evaluation, Preclinical; D008297:Male; D051379:Mice; D009046:Motor Neurons / Q000187:drug effects* / Q000378:metabolism; D009419:Nerve Tissue Proteins / Q000096:biosynthesis / Q000187:drug effects; D010743:Phospholipids / Q000378:metabolism; D011041:Poisoning / Q000188:drug therapy / Q000378:metabolism / Q000401:mortality
chemical_list: D000931:Antidotes; D009419:Nerve Tissue Proteins; D010743:Phospholipids; D001905:Botulinum Toxins; D002794:Choline
vernacular_title: Nespetsificheskie mekhanizmy farmakologicheskoĭ korrektsii troficheskoĭ nedostatochnosti motoneĭronov pri éksperimental'noĭ botulinicheskoĭ intoksikatsii.