[Chemosensitivity testing of adenocystic tongue and gingival cancer cell lines].
Chemosensitivity testing of adenocystic, tongue and gingiva cancer cell lines to 14 antitumor drugs using a tetrazolium-based colorimetric assay (MTT assay) was carried out and the values of the relative antitumor activity (RAA) of the drugs were compared. Adriamycin (ADM), methotrexate (MTX) and fluorouracil (5-FU) showed the most potent RAA against the cell lines while Cantharidin (CTD) did not show RAA. The rank orders of other 10 drugs against each cell line differed from each another.
Wu
J Z
JZ
Stomatological Collegy, Fourth Military Medical University, Xian.
D000970:Antineoplastic Agents / Q000494:pharmacology*; D003536:Cystadenocarcinoma / Q000473:pathology*; D004317:Doxorubicin / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D005472:Fluorouracil / Q000494:pharmacology; D005887:Gingival Neoplasms / Q000473:pathology*; D006801:Humans; D008727:Methotrexate / Q000494:pharmacology; D014062:Tongue Neoplasms / Q000473:pathology*; D014407:Tumor Cells, Cultured / Q000187:drug effects
D000970:Antineoplastic Agents; D004317:Doxorubicin; D005472:Fluorouracil; D008727:Methotrexate