Immune proteins in peripheral tissue fluid-lymph in patients with filarial lymphedema of the lower limbs.
Immune proteins and cytokine concentrations and activity were measured in skin tissue fluid-lymph and blood serum of patients with lower leg filarial lymphedema. High levels of lymph gamma-globulins, alpha-1-acid glycoprotein and IgG lymph/serum ratio were found. Lymph from filarial patients had an elevated lymph stimulatory effect on blood mononuclear cell culture with phytohemagglutinin. There was also a high concentration and activity of IL-1 beta but gamma-interferon was not detected. The deranged pattern of immune proteins and high activity of IL-1 suggest persistence of an ongoing local inflammatory process despite the absence of overt dermatitis. The high tissue-lymph IL-1 concentration and activity may signify a cytokine network promoting keratinocyte and fibroblast proliferation commonly seen on skin histology in patients with filariasis.
Olszewski
W L
WL
Department of Surgical Research & Transplantology, Polish Academy of Sciences, Warsaw.
Jamal
S
S
Lukomska
B
B
Manokaran
G
G
Grzelak
I
I
D000293:Adolescent; D000328:Adult; D016207:Cytokines / Q000032:analysis; D004605:Elephantiasis, Filarial / Q000276:immunology*; D005260:Female; D006023:Glycoproteins / Q000032:analysis; D006801:Humans; D007375:Interleukin-1 / Q000032:analysis; D007866:Leg; D008196:Lymph / Q000276:immunology*; D008297:Male; D008875:Middle Aged; D011506:Proteins / Q000032:analysis*; D005719:gamma-Globulins / Q000032:analysis
D016207:Cytokines; D006023:Glycoproteins; D007375:Interleukin-1; D011506:Proteins; D005719:gamma-Globulins