title: The influence of different levels of PEEP on peripheral tissue perfusion measured by subcutaneous and transcutaneous oxygen tension.
abstract: OBJECTIVE
  To compare subcutaneous (PscO2) and transcutaneous (PtcO2) oxygen tension measurements in relation to hemodynamic variables at different levels of PEEP, and to evaluate the usefulness of these measurements as monitors of peripheral tissue perfusion.
  
  
  METHODS
  Prospective trial.
  
  
  METHODS
  Intensive care unit in a university hospital.
  
  
  METHODS
  Seven patients with gastric cancer who where undergoing total gastrectomy.
  
  
  METHODS
  Silicone catheter was placed in the upper arm and transcutaneous oxygen monitor was placed on the upper part of the chest. A pulmonary artery catheter was placed in the right pulmonary artery.
  
  
  RESULTS
  PscO2 and PtcO2 together with hemodynamic variables were measured at different levels of PEEP. Progressive increase of PEEP reduced cardiac index (CI) (p < 0.05) with a concomitant decrease of PscO2 (p < 0.05) and oxygen delivery (DO2) (p < 0.05). Changes in PtcO2 paralleled changes in arterial oxygen tension (PaO2), but no correlation was found between PtcO2, CI and DO2.
  
  
  CONCLUSIONS
  PscO2 is a sensitive indicator of subcutaneous tissue perfusion, which can be used to identify the PEEP level, with optimum peripheral perfusion. PscO2 seems to be a more reliable indicator of tissue perfusion than PtcO2.
authors.affiliation: Department of Anaesthesiology, Malmö General Hospital, University of Lund, Sweden.
authors.forename: M
authors.initials: M
authors.lastname: Hartmann
authors.forename: B
authors.initials: B
authors.lastname: Rosberg
authors.forename: K
authors.initials: K
authors.lastname: Jönsson
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D001784:Blood Gas Analysis / Q000592:standards; D001785:Blood Gas Monitoring, Transcutaneous / Q000295:instrumentation / Q000379:methods / Q000592:standards*; D002302:Cardiac Output; D002407:Catheterization, Swan-Ganz; D005069:Evaluation Studies as Topic; D005743:Gastrectomy; D006801:Humans; D007362:Intensive Care Units; D008875:Middle Aged; D008991:Monitoring, Physiologic / Q000295:instrumentation / Q000379:methods / Q000592:standards*; D010100:Oxygen / Q000097:blood* / Q000493:pharmacokinetics; D010101:Oxygen Consumption; D011048:Polarography / Q000295:instrumentation / Q000379:methods / Q000592:standards*; D011175:Positive-Pressure Respiration / Q000379:methods / Q000592:standards*; D011446:Prospective Studies; D012680:Sensitivity and Specificity; D013274:Stomach Neoplasms / Q000601:surgery; D014018:Tissue Distribution; D014065:Tonometry, Ocular / Q000295:instrumentation / Q000379:methods / Q000592:standards*
chemical_list: D010100:Oxygen