title: Acute surgical abdomen in systemic lupus erythematosus--an analysis of 10 cases.
abstract: Gastrointestinal manifestations in a lupus patient may be due to different aetiologies such as vasculitis or a surgical condition. Problems of diagnosis are frequently encountered because the clinical presentations may mimic each other. We analysed ten lupus patients with acute surgical abdomen to identify the clinical, laboratory and radiological features that may aid in early diagnosis and management. Three patients with surgical abdomen had concomitant active lupus. Intra-abdominal sepsis and bleeding peptic ulcer disease constituted two major causes of laparotomies. Overt signs of peritonitis might not be present due to steroid masking effect. There were no specific clinical features, laboratory or radiological tests that could distinguish gastrointestinal vasculitis from acute surgical abdomen. Blood cultures, C-reactive protein and CT abdomen were useful adjuncts in the management of abdominal sepsis. No correlation was found between the timing of surgery, mortality, steroid dosage and wound complication.
authors.affiliation: Department of Rheumatology & Immunology, Tan Tock Seng Hospital, Singapore.
authors.forename: E T
authors.initials: ET
authors.lastname: Koh
authors.forename: M L
authors.initials: ML
authors.lastname: Boey
authors.forename: P H
authors.initials: PH
authors.lastname: Feng
mesh_terms: D000006:Abdomen, Acute / Q000209:etiology* / Q000601:surgery; D000328:Adult; D001064:Appendicitis / Q000150:complications / Q000601:surgery; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000150:complications* / Q000601:surgery; D010438:Peptic Ulcer Hemorrhage / Q000150:complications / Q000601:surgery; D010439:Peptic Ulcer Perforation / Q000150:complications / Q000601:surgery; D011183:Postoperative Complications / Q000209:etiology; D013530:Surgical Wound Infection / Q000209:etiology; D014657:Vasculitis / Q000150:complications / Q000601:surgery