Adenosine's role in the genesis of bradyarrhythmias induced by acute myocardial hypoxia.
A close or even causal relation between myocardial adenosine and bradyarrhythmias during acute myocardial hypoxia was testified in guinea pig, rabbit and dog mainly by using specific competitive antagonist and synchronous quantitative analysis of 3 variables: intensity of myocardial hypoxia, degree of endogenous adenosine increment and severity of bradyarrhythmias. Results disclosed: A) striking resemblance of the bradyarrhythmias with hypoxic origin to those caused by exogenous adenosine, B) same locality of A-V conduction block induced by both myocardial hypoxia and exogenous adenosine, C) precise parallelism among the above-listed 3 variables with very high correlativity (r = 0.99, P < 0.01), D) frequent accompaniment of reversal of hypoxic bradyarrhythmias through resupply of 21% O2 with normalization of preexisted increase in myocardial adenosine, E) satisfactory blockade of hypoxic bradyarrhythmias by adenosine's specific antagonist--aminophylline and their augmentation by adenosine's uptake inhibitor--dipyridamole, F) close similarity of the characteristic curve representing relation among the above 3 variables to that among intensity of myocardial hypoxia, degree of endogenous adenosine increment and amount of coronary blood flow in which adenosine's role as a mediator has been well documented and G) reproducible persistence of bradyarrhythmias during myocardial hypoxia irrespective of preliminary vagotomy and atropinization, denoting independence of the occurrence of such dysarrhythmias upon vagal drive, suggestive of a mechanism other than vagotonia. We advocated that hypoxia-induced bradyarrhythmias was caused by increment in endogenous adenosine.
Sun
J W
JW
Department of Pathophysiology, Capital Institute of Medicine, Beijing.
Yuan
F
F
Xu
J
J
Meng
F Y
FY
D000241:Adenosine / Q000378:metabolism / Q000494:pharmacology / Q000502:physiology*; D000628:Aminophylline / Q000494:pharmacology; D000818:Animals; D001919:Bradycardia / Q000209:etiology*; D004176:Dipyridamole / Q000494:pharmacology; D004285:Dogs; D004562:Electrocardiography; D006168:Guinea Pigs; D006327:Heart Block / Q000209:etiology; D066298:In Vitro Techniques; D017202:Myocardial Ischemia / Q000150:complications / Q000378:metabolism*; D011817:Rabbits; D014630:Vagus Nerve / Q000502:physiology
D000628:Aminophylline; D004176:Dipyridamole; D000241:Adenosine