[An analysis of the connection between the inhibition of NAD biosynthesis and the antitumor activity of drugs].
The study was concerned with a relationship between a decrease in NAD concentration and inhibition of precursor utilization for NAD biosynthesis, on the one hand, and inhibition of Ehrlich ascitic carcinoma growth in response to treatment with embichin, cyclophosphamide, thiophosphamide, adriablastin and methotrexate, on the other. The antitumor effect of drugs was found to be determined by degree of inhibition of precursor utilization for NAD biosynthesis but not by a decrease in NAD level. A relationship between alteration of synchronous induction of NAD and poly (ADP-ribose) biosynthesis rates and reversibility of the antitumor effect of drugs is discussed.
Reztsova
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Filov
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Stukov
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D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology* / Q000627:therapeutic use; D002286:Carcinoma, Ehrlich Tumor / Q000188:drug therapy / Q000378:metabolism; D004354:Drug Screening Assays, Antitumor; D005260:Female; D051379:Mice; D008815:Mice, Inbred Strains; D009243:NAD / Q000037:antagonists & inhibitors* / Q000096:biosynthesis; D009368:Neoplasm Transplantation; D009525:Niacin / Q000378:metabolism; D009536:Niacinamide / Q000378:metabolism; D013997:Time Factors
D000970:Antineoplastic Agents; D009243:NAD; D009536:Niacinamide; D009525:Niacin
Analiz sviazi mezhdu ingibirovaniem biosinteza NAD i protivoopukholevoĭ aktivnost'iu preparatov.