Epithelioid cell histiocytoma. A clinicopathologic and immunohistochemical study of eight cases.
BACKGROUND
Epithelioid cell histiocytomas histologically resemble the intradermal form of Spitz nevus.


OBJECTIVE
We have studied eight patients with epithelioid cell histiocytoma.


METHODS
In addition to the routine stains, histologic sections were prepared by immunohistochemical techniques for S-100 protein, HMB-45, vimentin, alpha 1-antitrypsin, and common leukocyte antigen.


RESULTS
Epithelioid cell histiocytoma is characterized by proliferation of angulated epithelioid cells with abundant eosinophilic cytoplasm. Immunostaining for S-100 protein and HMB-45 were negative. The majority of cells had positive reactions to staining for vimentin and alpha 1-antitrypsin. Approximately 20% to 25% of cells also gave positive reactions to common leukocyte antigen.


CONCLUSIONS
Immunostainings are useful in the differential diagnosis of epithelioid cell histiocytoma from the intradermal form of Spitz nevus.
Mehregan
A H
AH
Pinkus Dermatopathology Laboratory, Monroe, Michigan.
Mehregan
D R
DR
Broecker
A
A
D000328:Adult; D000368:Aged; D001399:Azure Stains; D015622:Epithelioid Cells / Q000473:pathology; D005260:Female; D018219:Histiocytoma, Benign Fibrous / Q000473:pathology*; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008875:Middle Aged; D009506:Nevus / Q000473:pathology; D012878:Skin Neoplasms / Q000473:pathology*
D001399:Azure Stains