[Clinical and experimental study on shen-qi injection with chemotherapy in the treatment of malignant tumor of digestive tract].
Shen-Qi (Ginseng-Astragalus) injection was used with chemotherapy in the treatment of 176 cases of malignant tumor of the digestive tract. Results showed that Shen-Qi injection could reduce the toxic effects produced by chemical agents and increase the patient's body weight, as compared with that treated by chemotherapy alone (P < 0.001). It could protect the body's hematopoietic function. In Shen-Qi injection with chemotherapy group; the WBC count changed insignificantly but in chemotherapy group the WBC count reduced markedly, in which the rate of chemotherapy failure was 26.5% the difference between these two groups appeared to be significant (P < 0.01). Shen-Qi injection could increase the cellular immunologic function of the body, including phagocytic index and percentage of phagocytes, T lymphocyte transformation rate(cpm) as well as esterase stain. Further more, Shen-Qi injection could promote blood circulation to remove blood stasis and reduce the whole blood specific viscosity (P < 0.05). In the animal experiment, the total number of bone marrow cells and karyocytes of combined treatment group was found to be higher (P < 0.001) and the average weight of thymus was heavier (P < 0.05) than that in chemotherapy group. Shen-Qi injection could also prolong the survival time and increase the tumor inhibiting rate of experimental mice.
Li
N Q
NQ
Dongzhimen Hospital, Beijing College of TCM.
D000230:Adenocarcinoma / Q000188:drug therapy; D000328:Adult; D000368:Aged; D000818:Animals; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D001809:Blood Viscosity / Q000187:drug effects; D003110:Colonic Neoplasms / Q000188:drug therapy; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use*; D006801:Humans; D007958:Leukocyte Count / Q000187:drug effects; D051379:Mice; D008875:Middle Aged; D009929:Organ Size / Q000187:drug effects; D012004:Rectal Neoplasms / Q000188:drug therapy*; D013274:Stomach Neoplasms / Q000188:drug therapy*; D013950:Thymus Gland / Q000473:pathology
D004365:Drugs, Chinese Herbal