title: Multicentric development of pancreatic intraductal carcinoma through atypical papillary hyperplasia.
abstract: We report a case of multiple intraductal carcinomas of the pancreas associated with diffuse atypical papillary hyperplasia. A 67-year-old Japanese man with a complaint of epigastric pain was examined by endoscopic retrograde pancreatography, which demonstrated multiple dilated branches of the pancreatic duct in the body and tail of the pancreas. Histologic examination on the resected pancreas showed diffuse atypical papillary hyperplasia in multiple dilated ducts associated with multiple intraductal carcinomas. Histologic features are described and multicentric carcinogenesis through atypical papillary hyperplasia is discussed.
authors.affiliation: Third Department of Internal Medicine, Asahikawa Medical College, Hokkaido, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Obara
authors.forename: Y
authors.initials: Y
authors.lastname: Saitoh
authors.forename: H
authors.initials: H
authors.lastname: Maguchi
authors.forename: H
authors.initials: H
authors.lastname: Ura
authors.forename: S
authors.initials: S
authors.lastname: Kitazawa
authors.forename: Y
authors.initials: Y
authors.lastname: Koike
authors.forename: K
authors.initials: K
authors.lastname: Okamura
authors.forename: M
authors.initials: M
authors.lastname: Namiki
mesh_terms: D000368:Aged; D002285:Carcinoma, Intraductal, Noninfiltrating / Q000473:pathology*; D002471:Cell Transformation, Neoplastic; D006801:Humans; D006965:Hyperplasia; D008297:Male; D010190:Pancreatic Neoplasms / Q000473:pathology*