title: Thrombocytopenia associated with administration of trimethoprim/sulfadiazine in a dog.
abstract: A diagnosis of trimethoprim/sulfadiazine-induced, immune-mediated thrombocytopenia in a dog was made, using a novel in vitro assay for thrombolytic activity. The assay quantifies thrombolytic activity by measuring the amount of platelet fragments in normal canine platelets before and after incubation with plasma from the thrombocytopenic dog. This report confirms previous reports of the development of thrombocytopenia after administration of trimethoprim/sulfadiazine, and describes a new assay that, after further validation, may be useful in the diagnosis of immune-mediated thrombocytopenia when an adequate sample of platelets cannot be obtained for quantification of platelet-associated IgG.
authors.affiliation: Department of Animal Science, College of Veterinary Medicine, University of Tennessee, Knoxville 37901-1071.
authors.forename: P S
authors.initials: PS
authors.lastname: Sullivan
authors.forename: K
authors.initials: K
authors.lastname: Arrington
authors.forename: R
authors.initials: R
authors.lastname: West
authors.forename: T P
authors.initials: TP
authors.lastname: McDonald
mesh_terms: D000818:Animals; D000890:Anti-Infective Agents / Q000009:adverse effects* / Q000627:therapeutic use; D001792:Blood Platelets / Q000276:immunology / Q000473:pathology; D004283:Dog Diseases / Q000139:chemically induced*; D004285:Dogs; D004338:Drug Combinations; D004844:Epistaxis / Q000662:veterinary; D005260:Female; D010976:Platelet Count / Q000662:veterinary; D013411:Sulfadiazine / Q000009:adverse effects* / Q000627:therapeutic use; D013921:Thrombocytopenia / Q000139:chemically induced / Q000662:veterinary*; D014295:Trimethoprim / Q000009:adverse effects* / Q000627:therapeutic use; D014627:Vaginitis / Q000188:drug therapy / Q000662:veterinary; D000096926:Benzenesulfonamides
chemical_list: D000890:Anti-Infective Agents; D004338:Drug Combinations; D013411:Sulfadiazine; D014295:Trimethoprim; C024873:sulfadiazine, trimethoprim drug combination; D000096926:Benzenesulfonamides