The in vitro and in vivo biotransformation of N-deacetyl-N-formylcolchicine.
The major pathway of metabolic transformation of N-deacetyl-N-formylcolchicine is the oxidative cytochrome P450 dependent O-demethylation of substituents in the aromatic ring A and tropolone ring C. It was found that O-demethylation (both, in vitro and in vivo) takes place predominantly in the aromatic ring, especially at position 2.
Lukić
V
V
Institute of Chemistry, Faculty of Sciences, University of Novi Sad, Yugoslavia.
Husek
A
A
Gasić
O
O
Walterova
D
D
Simanek
V
V
D000818:Animals; D001711:Biotransformation; D003078:Colchicine / Q000031:analogs & derivatives* / Q000493:pharmacokinetics*; D003640:Dealkylation; D066298:In Vitro Techniques; D008297:Male; D008862:Microsomes, Liver / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar
C080994:N-deacetyl-N-formylcolchicine; D003078:Colchicine