title: [Esophageal tumor induction in monkeys].
abstract: The experiment used eight monkeys who had received such esophagotropic carcinogens as ethyl ester of N-nitrososarcosine and methyl-N-benzyl-N-nitrosamine. The animals were followed for 4 years. The former agent failed to induce cancer where as 3 monkeys who had received methyl-N-benzyl-N-nitrosamine in the total dose of 600, 625 and 720 mg developed esophageal tumors (papilloma-2 and squamous cell carcinoma-1) at days 527, 725 and 880 after the start of treatment. The biological and histological features of the tumors were close to those of their human counterparts.
authors.forename: D Sh
authors.initials: DSh
authors.lastname: Beniashvili
authors.forename: V A
authors.initials: VA
authors.lastname: Aleksandrov
authors.forename: K I
authors.initials: KI
authors.lastname: Bardadze
authors.forename: V G
authors.initials: VG
authors.lastname: Bespalov
authors.forename: A S
authors.initials: AS
authors.lastname: Petrov
authors.forename: M S
authors.initials: MS
authors.lastname: Sartaniia
mesh_terms: D000818:Animals; D002273:Carcinogens; D002294:Carcinoma, Squamous Cell / Q000139:chemically induced* / Q000473:pathology; D004128:Dimethylnitrosamine / Q000031:analogs & derivatives; D004195:Disease Models, Animal; D004938:Esophageal Neoplasms / Q000139:chemically induced* / Q000473:pathology; D004945:Esophagoscopy; D004947:Esophagus / Q000473:pathology; D005260:Female; D008252:Macaca fascicularis; D008297:Male; D009602:Nitrosamines; D010212:Papilloma / Q000139:chemically induced* / Q000473:pathology; D013997:Time Factors
chemical_list: D002273:Carcinogens; D009602:Nitrosamines; C028099:N-nitrososarcosine ethyl ester; C014707:nitrosobenzylmethylamine; C013162:N-nitrososarcosine; D004128:Dimethylnitrosamine
vernacular_title: Induktsiia opukholeĭ pishchevoda u obez'ian.