[The individual characteristics of the activity of the DNA-repair enzyme O(6)-alkylguanine-DNA alkyltransferase in the stomach of monkeys exposed to the gastric carcinogen N-ethyl-N1-nitro-N-nitrosoguanidine].
Variations in the activity of a DNA repair enzyme 0(6)-alkylgianine-DNA alkyltransferase (AGT) were studied in gastric mucosa samples obtained from 15 M. fascicularis monkeys chronically exposed to a gastrocarcinogen N-ethyl-N'-nitro-N-nitrosoguanidine. Marked interindividual difference in the enzyme activity before and in the course of the exposure was observed. The value of AGT activity assay to predict individual susceptibility to alkylating carcinogens is discussed.
Loktionova
N A
NA
Beniashvili
D Sh
DSh
Zabezhinskiĭ
M A
MA
Kazanova
O I
OI
Petrov
A S
AS
Likhachev
A Ia
AIa
D000818:Animals; D001706:Biopsy; D002273:Carcinogens / Q000633:toxicity*; D004260:DNA Repair / Q000187:drug effects*; D005260:Female; D005753:Gastric Mucosa / Q000187:drug effects* / Q000201:enzymology / Q000473:pathology; D007962:Leukocytes / Q000187:drug effects / Q000201:enzymology; D008252:Macaca fascicularis; D008297:Male; D008769:Methylnitronitrosoguanidine / Q000031:analogs & derivatives* / Q000633:toxicity; D008780:Methyltransferases / Q000187:drug effects* / Q000378:metabolism; D019853:O(6)-Methylguanine-DNA Methyltransferase; D013274:Stomach Neoplasms / Q000139:chemically induced / Q000201:enzymology / Q000473:pathology; D013997:Time Factors
D002273:Carcinogens; D008769:Methylnitronitrosoguanidine; C013525:ENNG; D008780:Methyltransferases; D019853:O(6)-Methylguanine-DNA Methyltransferase
Individual'nye osobennosti aktivnosti fermenta reparatsii DNK O(6)-alkilguanin-DNK alkiltransferazy zheludka obez'ian, podvergnutykh vozdeĭstviiu gastrokantserogena N-étil-N1-nitro-N-nitrozoguanidina.