title: [Correction of primary and secondary immunodeficiency with synthetic beta-carotene].
abstract: Immunotropic activity of artificial beta-carotene was studied in primary immune response to thymus-dependent antigen (sheep erythrocytes) using models of primary (inherent) and acquired (vinblastine-induced) immunodeficiency. The experiments were carried out using two strains of CBA and C57Black mice with dissimilar responses to the antigen. beta-Carotene was found to remove both acquired and inherent immunodeficiency. The immunostimulating effect of the drug studied appears to be related to the activated production of mediators, namely IL-2.
authors.forename: O V
authors.initials: OV
authors.lastname: Buiuklinskaia
mesh_terms: D000818:Animals; D000921:Antibody-Producing Cells / Q000187:drug effects / Q000378:metabolism; D002338:Carotenoids / Q000494:pharmacology*; D007153:Immunologic Deficiency Syndromes / Q000188:drug therapy*; D007376:Interleukin-2 / Q000096:biosynthesis; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D019207:beta Carotene
chemical_list: D007376:Interleukin-2; D019207:beta Carotene; D002338:Carotenoids
vernacular_title: Korrektsiia pervichnogo i vtorichnogo immunodefitsita sinteticheskim beta-karotinom.