[In vivo and in vitro antitumoral effects of an extract from Vibrio cholerae in different murine models. II. Antitumoral effect in vitro of an extract from Vibrio cholerae: inhibition of 3LL cell growth and stimulation of murine splenocytes].
A bacterial extract from Vibrio cholerae, the DGZ, has been separated into two fractions by gel filtration. The effects of these two fractions and that of the crude extract are investigated and compared by two different in vitro tests. It appears that these extracts exert direct inhibition over the growth of 3LL cultured cells and that they trigger splenocytes in vitro proliferation.
Delorme
L
L
Unité Choléra et Vibrions, Institut Pasteur, Paris.
Dodin
A
A
Zylberberg
B
B
D000818:Animals; D000970:Antineoplastic Agents / Q000302:isolation & purification / Q000494:pharmacology*; D002277:Carcinoma / Q000473:pathology; D002455:Cell Division / Q000187:drug effects; D066298:In Vitro Techniques; D008175:Lung Neoplasms / Q000473:pathology; D051379:Mice; D008810:Mice, Inbred C57BL; D051381:Rats; D011917:Rats, Inbred Lew; D013154:Spleen / Q000166:cytology*; D014407:Tumor Cells, Cultured / Q000187:drug effects; D014734:Vibrio cholerae / Q000737:chemistry*
D000970:Antineoplastic Agents
Effets antitumoraux in vivo et in vitro d'un extrait de Vibrio cholerae dans différents modèles murins. II. Effet antitumoral in vitro d'un extrait de Vibrio cholerae: inhibition de la croissance des cellules 3LL et stimulation de splénocytes murins.