title: Wheat-dependent exercise-induced anaphylaxis: inhibition by sodium bicarbonate.
abstract: We present a case of wheat-dependent exercise-induced anaphylaxis, in which pretreatment with sodium bicarbonate inhibited reappearance of anaphylactic symptoms following wheat and exercise provocation. Decrease in blood pH relative to elevation in plasma histamine levels was also inhibited. These results suggest possible efficacy of pretreatment with sodium bicarbonate as a preventive measure in patients with exercise-induced anaphylaxis.
authors.affiliation: Department of Allergy, National Children's Hospital, Tokyo, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Katsunuma
authors.forename: Y
authors.initials: Y
authors.lastname: Iikura
authors.forename: A
authors.initials: A
authors.lastname: Akasawa
authors.forename: A
authors.initials: A
authors.lastname: Iwasaki
authors.forename: K
authors.initials: K
authors.lastname: Hashimoto
authors.forename: K
authors.initials: K
authors.lastname: Akimoto
mesh_terms: D000328:Adult; D000707:Anaphylaxis / Q000209:etiology* / Q000517:prevention & control; D001639:Bicarbonates / Q000627:therapeutic use; D015444:Exercise; D006632:Histamine / Q000097:blood; D006801:Humans; D008297:Male; D012964:Sodium / Q000627:therapeutic use; D017693:Sodium Bicarbonate; D013997:Time Factors; D014908:Triticum / Q000009:adverse effects*
chemical_list: D001639:Bicarbonates; D006632:Histamine; D017693:Sodium Bicarbonate; D012964:Sodium