[Leukocytolysis and phagocytosis under hyperosmotic conditions].
PAN and leukocytolysis were measured in dog blood placed in hypo- and hypertonic solutions of glycerin and glucose (1:10). It was found that leukocytolytic activity of the substances depends on equimolar concentrations of nonelectrolytes. It is more pronounced in hypo- than in hypertonic conditions. Glycerin is 3-5-times more active than glucose. In concentrations 2.0 M for glycerin and 0.5 M for glucose leukocytolysis is less active. Mononuclears are more resistant than neutrophils in strong solutions. PAN increased by 11-16% in hypotonic solutions. Strong glycerin solutions reduce PAN less than glucose which stimulates the digestive activity. The results can be of use in specific leukolysis tests to diagnose drug allergy.
Vavilov
M P
MP
Belopol'skiĭ
A A
AA
Apollonova
L A
LA
Nazarova
E K
EK
D000818:Animals; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D004285:Dogs; D004305:Dose-Response Relationship, Drug; D005947:Glucose / Q000494:pharmacology; D005990:Glycerol / Q000494:pharmacology; D006982:Hypertonic Solutions; D007038:Hypotonic Solutions; D007962:Leukocytes / Q000187:drug effects*; D009504:Neutrophils / Q000187:drug effects; D009994:Osmolar Concentration; D010587:Phagocytosis / Q000187:drug effects*; D013211:Staphylococcus aureus
D006982:Hypertonic Solutions; D007038:Hypotonic Solutions; D005947:Glucose; D005990:Glycerol
Leĭkotsitoliz i fagotsitoz v giperosmoticheskikh usloviiakh.