[Reactivity of pulmonary mast cells and peripheral blood basophils in patients with sarcoidosis and bronchial asthma].
We have studied the sensitivity of pulmonary mast cells and blood basophils in patients with sarcoidosis and bronchial asthma. The cells were induced in vitro with anti-IgE. The histamine releasing from mast cells and basophils was high in both examined groups of patients. The histamine releasing from mast cells in patients with sarcoidosis was 27.8-47.1% and in asthmatic patients 42.8-58.9%. The histamine releasing from basophils was 38.2-57.9% and 41.0-62.1%, respectively. The high sensitivity of mast cells of patients with sarcoidosis may suggest that these cells play an essential role in pathology of this disease.
Gaik
A
A
Kliniki Chorób Płuc IMW WAM, Lodzi.
Brzezińska-Błaszczyk
E
E
Jarzebska
M
M
Prochowski
M
M
Karczewska
M
M
D000328:Adult; D000888:Antibodies, Anti-Idiotypic / Q000276:immunology; D001249:Asthma / Q000097:blood / Q000276:immunology / Q000473:pathology*; D001491:Basophils / Q000276:immunology / Q000378:metabolism*; D001992:Bronchoalveolar Lavage Fluid / Q000473:pathology*; D005260:Female; D006636:Histamine Release / Q000276:immunology / Q000502:physiology*; D006801:Humans; D066298:In Vitro Techniques; D008168:Lung / Q000473:pathology*; D008171:Lung Diseases / Q000097:blood / Q000276:immunology / Q000473:pathology*; D008297:Male; D008407:Mast Cells / Q000276:immunology / Q000378:metabolism*; D008875:Middle Aged; D012507:Sarcoidosis / Q000097:blood / Q000276:immunology / Q000473:pathology*
D000888:Antibodies, Anti-Idiotypic; C026408:anti-IgE antibodies
Reaktywność mastocytów płuc i granulocytów zasadochłonnych krwi obwodowej u chorych na sarkoidoze i astme oskrzelowa.