[Anti-tumour study of combined therapy of yi kang ling with chemotherapeutic agents].
Result of animal experiment proved that Yi Kang Ling, a TCM compound preparation, could markedly inhibit the growth of implanted tumour in mice. The inhibiting effect to the experimental tumour of combined therapy of Yi Kang Ling and the chemotherapeutic agents-CTX or MMC was better than that using singly. The Yi Kang Ling could alleviate toxicity of chemotherapy which caused the weight loss of mice. It could markedly increase the immune organs' weight, raise the phagocytosis of abdominal macrophage and promote the formation of serum hemolysin inhibited by CTX. The experimental result revealed that the combined therapy of Yi Kang Ling and the chemotherapeutical agents could enhance anti-tumour effect and lower the toxicity of chemotherapy. Toxicological experiment showed that the Yi Kang Ling did not have any toxic effect against organism.
Zhang
Y H
YH
Shandong Academy of Medical Sciences, Jinan.
Qi
Q J
QJ
D000276:Adjuvants, Immunologic; D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000008:administration & dosage* / Q000494:pharmacology; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D002286:Carcinoma, Ehrlich Tumor / Q000188:drug therapy*; D003520:Cyclophosphamide / Q000008:administration & dosage; D004365:Drugs, Chinese Herbal / Q000008:administration & dosage* / Q000494:pharmacology; D005260:Female; D008297:Male; D051379:Mice; D016685:Mitomycin / Q000008:administration & dosage; D009368:Neoplasm Transplantation; D010587:Phagocytosis / Q000187:drug effects; D012510:Sarcoma 180 / Q000188:drug therapy*
D000276:Adjuvants, Immunologic; D000972:Antineoplastic Agents, Phytogenic; D004365:Drugs, Chinese Herbal; D016685:Mitomycin; D003520:Cyclophosphamide