title: [Two cases of severe cutaneous vasculitis with thrombocytopenia associated with hepatic cirrhosis: autoimmune and infective-inflammatory component with endothelial lesion and restrictive pulmonary pattern in one case].
abstract: Two clinical cases of female patients with hepatic cirrhosis and autoimmune multisystemic involvement with infectious intercurrent are reported. Case 1 presented infective endocarditis and erysipelas on the left thigh. In the course of the clinical picture a cutaneous vasculitis developed in the same place together with autoimmune thrombocytopenia, leukopenia and pulmonary restrictive picture with inflammatory pattern. There are also elevate immune complexes and complement consumption. Case 2 presented erysipelas on the left thigh cutaneous vasculitis and complement consumption. In Case 1 the infective endocarditis was treated with antibiotic therapy during 4 weeks followed by 1 mg/kg corticoid (Prednisone) with thrombocytopenia and leukopenia reversion. Case 2 presented an improvement with antibiotic only. The relation between chronic liver diseases and systemic autoimmune phenomena is commented, special attention being paid to the cutaneous, hematological and pulmonary affection.
authors.affiliation: Serviço de Clínica Geral e Propedêutica do Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo, HC-FMUSP.
authors.forename: D R
authors.initials: DR
authors.lastname: de Andrade Júnior
authors.forename: M do P
authors.initials: Mdo P
authors.lastname: Warth
authors.forename: L F
authors.initials: LF
authors.lastname: Morrone
authors.forename: I
authors.initials: I
authors.lastname: Calich
authors.forename: D R
authors.initials: DR
authors.lastname: de Andrade
mesh_terms: D000328:Adult; D001323:Autoantibodies / Q000032:analysis; D001327:Autoimmune Diseases / Q000150:complications* / Q000276:immunology; D004886:Erysipelas / Q000150:complications / Q000276:immunology; D005260:Female; D006801:Humans; D008103:Liver Cirrhosis / Q000150:complications* / Q000276:immunology; D008875:Middle Aged; D015985:Precipitating Factors; D013921:Thrombocytopenia / Q000150:complications* / Q000276:immunology; D018366:Vasculitis, Leukocytoclastic, Cutaneous / Q000150:complications* / Q000175:diagnosis / Q000276:immunology
chemical_list: D001323:Autoantibodies
vernacular_title: Dois casos de vasculite cutânea grave com plaquetopenia associada à cirrose hepática: componente autoimune e infecto-inflamatório com lesão endotelial e padrão restritivo pulmonar em um caso.