[The activity of mitochondrial enzymes in the myocardium in chronic coronary failure during the administration of antianginal agents].
The experiments with Chinchilla rabbits indicated that the activity of mitochondria-associated enzymes changed hetero-directionally in chronic coronary insufficiency. The activity of creatine kinase changed most greatly. Obsidan and finoptin were found to show a different effect on the activity of the tested enzymes in the cardiac mitochondria during experimental coronary insufficiency.
Voronkov
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GS
Evstratova
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IN
D000818:Animals; D002317:Cardiovascular Agents / Q000627:therapeutic use*; D002791:Cholesterol, Dietary / Q000008:administration & dosage; D002908:Chronic Disease; D003327:Coronary Disease / Q000188:drug therapy* / Q000201:enzymology* / Q000209:etiology; D004353:Drug Evaluation, Preclinical; D004734:Energy Metabolism / Q000187:drug effects; D008929:Mitochondria, Heart / Q000187:drug effects* / Q000201:enzymology*; D011433:Propranolol / Q000627:therapeutic use; D011817:Rabbits; D014700:Verapamil / Q000627:therapeutic use
D002317:Cardiovascular Agents; D002791:Cholesterol, Dietary; D011433:Propranolol; D014700:Verapamil
Aktivnost' nekotorykh mitokhondrial'nykh fermentov v miokarde pri khronicheskoĭ koronarnoĭ nedostatochnosti v usloviiakh vvedeniia antianginal'nykh sredstv.