Erythro-toxicity of dichlorvos and possibility of its modification in vitro.
The purpose of this study was to investigate the in vitro effects of dichlorvos (organophosphorous pesticide) on the biological value of erythrocytes; an in vitro test of erythrocyte protection against DDVP effects was also included. A significant decrease of glutathione level with concomitant increase of methemoglobin and denatured hemoglobin levels, as well as a rise of Heinz body number were observed after 24 h following the treatment with dichlorvos (100 microM). Preincubation of erythrocytes with glutathione prevented the toxic effects of the pesticide with the maintenance of both glutathione and methemoglobin at a control level.
Woźniak
J
J
Department of Physiopathology, Institute of Hematology and Blood Transfusion, Warsaw.
Grabarczyk
M
M
D002478:Cells, Cultured; D004006:Dichlorvos / Q000633:toxicity*; D004912:Erythrocytes / Q000737:chemistry / Q000187:drug effects*; D005978:Glutathione / Q000494:pharmacology*; D006454:Hemoglobins / Q000032:analysis; D006801:Humans; D008706:Methemoglobin / Q000032:analysis
D006454:Hemoglobins; D004006:Dichlorvos; D008706:Methemoglobin; D005978:Glutathione