[Inotropic action of Astragalus membranaceus Bge. saponins and its possible mechanism].
Astragalus membranaceus saponins (AMS) 50-200 micrograms/ml had a positive inotropic action on the isolated working heart of rats, but in the case of 30 micrograms/ml the inotropic action turned negative. The contractility recovered after washing out the AMS. Strophanthin K performed in a similar manner as AMS. AMS 500 micrograms/ml decreased the resting potential of cultured rat heart cells by 10 mV. The results suggest that AMS plays its inotropic role through influencing the Na-K-ATPase.
Wang
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Jilin Province, Central Hospital of Changchun City.
D000818:Animals; D027885:Astragalus propinquus; D002478:Cells, Cultured; D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000494:pharmacology*; D066298:In Vitro Techniques; D008564:Membrane Potentials / Q000187:drug effects; D009200:Myocardial Contraction / Q000187:drug effects*; D051381:Rats; D017208:Rats, Wistar; D012503:Saponins / Q000008:administration & dosage / Q000494:pharmacology*; D013268:Stimulation, Chemical; D013328:Strophanthins / Q000494:pharmacology
D004365:Drugs, Chinese Herbal; D012503:Saponins; D013328:Strophanthins; C029082:strophanthin K