[Changes in the content of reduced glutathione in the liver of mice under the action of staphylococcal enterotoxin type A and lipopolysaccharide].
We investigated the level of reduced glutathione in mouse liver after injection of staphylococcal enterotoxin type A (SEA) and Serratia marcescens endotoxin (LPS). It was shown that SEA caused significant glutathione depletion. Glutathione level fell more under the combined treatment by both toxins. The data demonstrate a considerable role of antioxidant potential in the mechanism of enhanced sensitivity of animals to the lethal effect produced by LPS.
Riabichenko
E V
EV
Ezepchuk
Iu V
IuV
D000818:Animals; D004768:Enterotoxins / Q000494:pharmacology*; D005978:Glutathione / Q000032:analysis / Q000187:drug effects* / Q000378:metabolism; D008070:Lipopolysaccharides / Q000494:pharmacology*; D008099:Liver / Q000737:chemistry / Q000187:drug effects* / Q000378:metabolism; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D010084:Oxidation-Reduction / Q000187:drug effects; D012706:Serratia marcescens; D013211:Staphylococcus aureus; D013997:Time Factors
D004768:Enterotoxins; D008070:Lipopolysaccharides; C026066:enterotoxin A, Staphylococcal; D005978:Glutathione
Izmenenie urovnia vosstanovlennogo glutationa v pecheni mysheĭ pod deĭstviem stafilokokkovogo énterotoksina tipa A i lipopolisakharida.