Antitumor activity of psoralen on mucoepidermoid carcinoma cell line MEC-1.
Psoralen (PSO) was found cytotoxic against in vitro cultured human mucoepidermoid carcinoma cells of MEC-1 cell line. Its IC50 value was 8.6 micrograms/ml, and relative antitumor activity (RAA) 15. PSO suppressed DNA synthesis, damaged microvilli and cell membrane, and induced degeneration of mitochondria. It inhibited the growth of MEC-1 cells transplanted in nude mice by 79.1% which was as strong as pingyanmycin (PYM 81.4%). The body weight loss of PSO treated tumor-bearing mice was 5%, whereas that of PYM treated ones 13.3% (P < 0.01). PSO may be an effective agent for the treatment of human mucoepidermoid carcinoma.
Wu
J Z
JZ
Stomatological Hospital, Fourth Military Medical University, Xi'an.
Situ
Z Q
ZQ
Wang
W
W
Chen
J Y
JY
Liu
B
B
D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology*; D002277:Carcinoma / Q000188:drug therapy / Q000473:pathology* / Q000648:ultrastructure; D004273:DNA, Neoplasm / Q000032:analysis; D005363:Ficusin / Q000494:pharmacology* / Q000627:therapeutic use; D006801:Humans; D051379:Mice; D008807:Mice, Inbred BALB C; D008819:Mice, Nude; D008854:Microscopy, Electron; D008855:Microscopy, Electron, Scanning; D009368:Neoplasm Transplantation; D012468:Salivary Gland Neoplasms / Q000188:drug therapy / Q000473:pathology* / Q000648:ultrastructure; D014407:Tumor Cells, Cultured / Q000187:drug effects
D000970:Antineoplastic Agents; D004273:DNA, Neoplasm; D005363:Ficusin