title: In vitro antibacterial activity of antiseptics against vaginal lactobacilli.
abstract: The results of investigations carried out to evaluate the inhibitory activity in vitro of seven vaginal antiseptic douche solutions against several strains of vaginal lactobacilli isolated from asymptomatic women are reported. Some of the products examined showed marked antibacterial activity even at high dilutions and for short exposure times. The post-antibiotic effect of two of these antiseptics on vaginal lactobacilli was also evaluated. The results of these investigations suggest that uncontrolled use of antiseptic products could cause changes in the normal vaginal flora.
authors.affiliation: Istituto di Tecnica Farmaceutica, Facoltà di Farmacia, Università di Sassari, Italy.
authors.forename: C
authors.initials: C
authors.lastname: Juliano
authors.forename: L
authors.initials: L
authors.lastname: Piu
authors.forename: E
authors.initials: E
authors.lastname: Gavini
authors.forename: S
authors.initials: S
authors.lastname: Zanetti
authors.forename: G
authors.initials: G
authors.lastname: Fadda
mesh_terms: D000891:Anti-Infective Agents, Local / Q000494:pharmacology*; D005260:Female; D006801:Humans; D007778:Lactobacillus / Q000187:drug effects*; D008826:Microbial Sensitivity Tests; D007507:Therapeutic Irrigation; D014621:Vagina / Q000382:microbiology*
chemical_list: D000891:Anti-Infective Agents, Local