Influence of ethanol on the antiarrhythmic activity of verapamil.
The aim of this work was to determine the influence of ethanol on the antiarrhythmic activity of verapamil in the model of calcium arrhythmia in rats non-dependent and dependent on ethanol. The results of the experiment show that a combined, single administration of ethanol and verapamil attenuates in a statistically significant manner the antiarrhythmic effect of verapamil. Ethanol administered repeatedly together with verapamil does not diminish the antiarrhythmic activity of verapamil.
Filipek
B
B
Department of Pharmacology, Medical Academy, Kraków, Poland.
Krupińska
J
J
Zebala
K
K
Szymańska
I
I
Librowski
T
T
Piekoszewski
W
W
D000437:Alcoholism / Q000150:complications; D000818:Animals; D001145:Arrhythmias, Cardiac / Q000139:chemically induced / Q000150:complications / Q000188:drug therapy*; D002122:Calcium Chloride; D004195:Disease Models, Animal; D004347:Drug Interactions; D000431:Ethanol / Q000097:blood / Q000633:toxicity*; D008297:Male; D051381:Rats; D014700:Verapamil / Q000494:pharmacology* / Q000627:therapeutic use
D000431:Ethanol; D014700:Verapamil; D002122:Calcium Chloride