Plasminogen activator in human tears.
Measurements were made of the nature and levels of plasminogen activator in human tears using, as a model of inflammation, patients undergoing cataract surgery. Tissue plasminogen activator (t-PA) but not urokinase plasminogen activator (u-PA) was found in tears. A wide variation in the range of t-PA in pre-operative tears was found. In those patients not receiving per-operative subconjunctival betamethasone a significant rise in t-PA was found in tears on the first post-operative day over pre-operative levels. A significant fall was noted in those receiving per-operative subconjunctival betamethasone.
Stevens
J D
JD
Department of Ophthalmology, University of Oxford, UK.
Marshall
J M
JM
Benjamin
L
L
Cederholm-Williams
S A
SA
Bron
A J
AJ
D001623:Betamethasone / Q000494:pharmacology; D002387:Cataract Extraction; D006801:Humans; D010960:Plasminogen Activators / Q000032:analysis* / Q000187:drug effects; D011184:Postoperative Period; D013666:Tears / Q000201:enzymology*; D010959:Tissue Plasminogen Activator / Q000032:analysis; D014568:Urokinase-Type Plasminogen Activator / Q000032:analysis
D001623:Betamethasone; D010960:Plasminogen Activators; D010959:Tissue Plasminogen Activator; D014568:Urokinase-Type Plasminogen Activator