title: Bioavailability and biological activity of L-ascorbic acid 2-O-alpha-glucoside.
abstract: AA-2G is a new stable derivative of AsA which is efficiently synthesized by regioselective transglucosylation with alpha-glucosidase and CGTase. AA-2G serves as a vitamin C supplement in experimental animals. AA-2G is easily hydrolyzed in vivo by alpha-glucosidase and also synthesized as a metabolite under some specified conditions. AA-2G stimulates collagen synthesis in cultured fibroblasts and enhances antibody production in cultured splenocytes. AA-2G which has no cytotoxicity is a promising AsA derivative for medical and nutritional uses.
authors.affiliation: Department of Immunochemistry, Okayama University, Japan.
authors.forename: I
authors.initials: I
authors.lastname: Yamamoto
authors.forename: N
authors.initials: N
authors.lastname: Muto
mesh_terms: D000818:Animals; D001205:Ascorbic Acid / Q000031:analogs & derivatives* / Q000737:chemistry / Q000493:pharmacokinetics / Q000494:pharmacology; D001682:Biological Availability; D006031:Glycosylation; D006801:Humans
chemical_list: C065378:ascorbic acid 2-O-glucoside; D001205:Ascorbic Acid