title: Cytokines in the pathogenesis of multiple sclerosis.
abstract: The authors evaluate the involvement of various cytokines (interleukin-1, interleukin-2, interleukin-4, interleukin-6, tumor necrosis factor alpha and gamma-interferon) in the pathogenesis of multiple sclerosis. The cytokines might participate in nervous tissue damage by promoting demyelination and oligodendrocyte injury or by enhancing local immune response. In addition, several authors reported increased levels of some cytokines in serum and cerebrospinal fluid of patients with multiple sclerosis. These findings suggest that cytokines can play a significant role in the immunopathogenesis of the disease.
authors.affiliation: I Clinica Neurologica, II Facoltà di Medicina, Università di Napoli.
authors.forename: P B
authors.initials: PB
authors.lastname: Carrieri
authors.forename: A
authors.initials: A
authors.lastname: Maiorino
authors.forename: V
authors.initials: V
authors.lastname: Provitera
authors.forename: E
authors.initials: E
authors.lastname: Soscia
authors.forename: O
authors.initials: O
authors.lastname: Perrella
mesh_terms: D016207:Cytokines / Q000032:analysis / Q000502:physiology*; D006801:Humans; D009103:Multiple Sclerosis / Q000209:etiology* / Q000378:metabolism / Q000503:physiopathology
chemical_list: D016207:Cytokines