Furan and thiophene analogues of omeprazole.
Synthesis and structure of some analogs of the omeprazole containing furan and thiophene rings are reported. Their effects on the basal and the histamine-stimulated secretion were evaluated on the isolated rat stomach.
Sorba
G
G
Dipartimento di Scienza e Tecnologia del Farmaco, Torino, Italy.
Di Stilo
A
A
Gili
M
M
Gasco
A
A
Bertaccini
G
G
Adami
M
M
Coruzzi
G
G
D000818:Animals; D000897:Anti-Ulcer Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D005663:Furans / Q000138:chemical synthesis* / Q000494:pharmacology; D005744:Gastric Acid / Q000378:metabolism; D066298:In Vitro Techniques; D008297:Male; D009853:Omeprazole / Q000031:analogs & derivatives* / Q000138:chemical synthesis; D051381:Rats; D013876:Thiophenes / Q000138:chemical synthesis* / Q000494:pharmacology
D000897:Anti-Ulcer Agents; D005663:Furans; D013876:Thiophenes; D009853:Omeprazole