title: Inactivation of keratin genes by gene targeting: a perspective.
abstract: Recent technological advances in experimental molecular genetics have provided an opportunity for determining the function of any gene including those which are important in different epithelia. This report summarizes some recent results of experiments utilizing gene targeting technology to determine the function of intermediate filaments and emphasizes both the problems and the potential of applying this technology to problems in dermatology.
authors.affiliation: La Jolla Cancer Research Foundation, CA 92037.
authors.forename: R G
authors.initials: RG
authors.lastname: Oshima
authors.forename: H
authors.initials: H
authors.lastname: Baribault
mesh_terms: D000818:Animals; D002454:Cell Differentiation; D005818:Genetic Engineering / Q000379:methods; D007633:Keratins / Q000235:genetics*; D051379:Mice
chemical_list: D007633:Keratins