Spectroscopic studies of the interaction of synthetic RNAs with quinacrine and its analogs.
The interaction of synthetic RNAs with quinacrine (QAC) and its analogs has been studied by absorption, fluorescence and circular dichroism (CD) measurements. The results indicate that the 2-methoxy group of the acridine ring plays an important role in the appearance of the new absorption band upon binding of QAC to poly-(rA).poly(rU).
Nakamura
S
S
Department of Chemistry, Faculty of Science, Yamaguchi University, Japan.
Yoshimatsu
S
S
Murakami
K
K
Kubota
Y
Y
D015394:Molecular Structure; D011063:Poly A-U / Q000737:chemistry; D011070:Poly I-C / Q000737:chemistry; D011796:Quinacrine / Q000031:analogs & derivatives / Q000737:chemistry*; D012313:RNA / Q000737:chemistry*; D013057:Spectrum Analysis
D011063:Poly A-U; D012313:RNA; D011796:Quinacrine; D011070:Poly I-C