title: Autosomal dominant branchio-oto-renal syndrome--localization of a disease gene to chromosome 8q by linkage in a Dutch family.
abstract: Branchio-oto-renal syndrome (BOR) is an autosomal dominant disorder with variable clinical manifestations affecting branchial, renal and auditory development. Varying clinical expression of the disease between different families suggests that multiple loci may be involved. However, the possibility of genetic heterogeneity as the cause of clinical variability cannot be resolved until the gene(s) causing BOR syndrome are mapped. DNA from four generations of a family with autosomal dominant BOR syndrome have been typed with a series of genetic markers on the long arm of chromosome 8. Using two point linkage analysis, a significant lod score of Z = 4.0 at theta = 0.05 was obtained with the D8S165 microsatellite marker. Multipoint analyses with 8q markers place the gene for BOR between the markers D8S87 and D8S165.
authors.affiliation: Department of Genetics, Boys Town National Research Hospital, Omaha, NE 68131.
authors.forename: S
authors.initials: S
authors.lastname: Kumar
authors.forename: W J
authors.initials: WJ
authors.lastname: Kimberling
authors.forename: J B
authors.initials: JB
authors.lastname: Kenyon
authors.forename: R J
authors.initials: RJ
authors.lastname: Smith
authors.forename: H A
authors.initials: HA
authors.lastname: Marres
authors.forename: C W
authors.initials: CW
authors.lastname: Cremers
mesh_terms: D000015:Abnormalities, Multiple / Q000235:genetics*; D001483:Base Sequence; D002874:Chromosome Mapping; D002898:Chromosomes, Human, Pair 8; D004277:DNA, Single-Stranded; D005260:Female; D005402:Fistula / Q000235:genetics; D005799:Genes, Dominant; D008040:Genetic Linkage; D006311:Hearing Disorders / Q000235:genetics; D006801:Humans; D007674:Kidney Diseases / Q000235:genetics; D008297:Male; D008969:Molecular Sequence Data; D009426:Netherlands; D010375:Pedigree; D016133:Polymerase Chain Reaction; D013577:Syndrome; D002577:Uterine Cervical Diseases / Q000235:genetics
chemical_list: D004277:DNA, Single-Stranded