title: The long-term use of cyproterone acetate in pedophilia: a case study.
abstract: This investigation reports the long-term use of the antiandrogen cyproterone acetate (CPA) in a pedophile, who was studied continuously over 38 months. Measures of sexual arousal, serum testosterone, and gonadotropin levels were significantly reduced by the drug as compared with placebo and no treatment; prolactin levels were significantly elevated. Some workers have observed that long-term administration of CPA (more than one year, which was then discontinued) produced enduring (in some cases apparently permanent) anti-libidinal effects; however, in the case described, within three weeks of stopping the drug, all measures had returned to pretrial levels. The importance of continuous long-term monitoring in sex offenders receiving an antiandrogen is discussed.
authors.affiliation: St. Thomas Psychiatric Hospital, Ontario, Canada.
authors.forename: A J
authors.initials: AJ
authors.lastname: Cooper
authors.forename: Z
authors.initials: Z
authors.lastname: Cernovsky
authors.forename: R V
authors.initials: RV
authors.lastname: Magnus
mesh_terms: D000328:Adult; D017373:Cyproterone Acetate / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*; D006065:Gonadotropins, Pituitary / Q000097:blood; D006801:Humans; D007989:Libido / Q000187:drug effects; D008297:Male; D010378:Pedophilia / Q000097:blood / Q000188:drug therapy*; D010410:Penile Erection / Q000187:drug effects; D013739:Testosterone / Q000097:blood; D013997:Time Factors
chemical_list: D006065:Gonadotropins, Pituitary; D013739:Testosterone; D017373:Cyproterone Acetate