[The dynamics of the reparative regeneration of the rat epidermis exposed to lysylproline].
Under study was the spatial distribution of mitotic activity (MA) of the rat epidermis in the process of reparative regeneration of the skin for a distance of 6 mm aside from the wound margin, as well as the action of lysyl-proline (LP) on the process which is a product of natural decay of collagen. The wound was made by cutting a skin flap (0.5 x 3 cm) from the area of the back. A teflon ring was introduced through the incision in the cranial direction at a distance of 3 cm. Control animals were given 1 ml of the isotonic solution of sodium chloride injected in the hole of the ring, for experimental animals the solution additionally contained 20 mkg of LP. Healing of the wound in control and experimental animals had the features generally corresponding to the regularities established earlier. It was also found that mitotic activity was growing irregularly forming waves. During 11 days of observations these waves sometimes came nearer to the center of the wound, sometimes moved away. The influence of LP manifested itself in the waves of MA reaching the wound center 1 day earlier, and the approximation and divergence of the waves were smoother, MA was higher and epithelialization of the wound surface also came 1 day earlier. Since the contraction of the wound in experimental animals was also more rapid (activization from the 3rd day), a conclusion can be made of the stimulating influence of LP on the course of the reparative regeneration of the epidermis observed as long as 1.5 weeks after a single injection of LP.(ABSTRACT TRUNCATED AT 250 WORDS)
Katinas
G S
GS
Petriaeva
M A
MA
D000818:Animals; D004151:Dipeptides / Q000494:pharmacology*; D000078404:Epidermal Cells; D004817:Epidermis / Q000187:drug effects* / Q000293:injuries / Q000502:physiology*; D008297:Male; D008938:Mitosis / Q000187:drug effects; D051381:Rats; D017208:Rats, Wistar; D012038:Regeneration / Q000187:drug effects*; D013373:Substance P / Q000494:pharmacology*; D013997:Time Factors; D014945:Wound Healing / Q000187:drug effects
D004151:Dipeptides; D013373:Substance P; C039356:lysylproline
Dinamika reparativnoĭ regeneratsii épidermisa krysy pri vozdeĭstvii lizil-prolinom.