[The kinetic observation of serum ketone body levels in surgical patients receiving MCT or LCT emulsions].
The changes of serum beta-hydroxybutyrate concentrations in patients after receiving medium chain triglycerides (MCT) or long chain triglycerides (LCT) were studied. The patients were divided into two groups: in Group 1, the dose of fat was 0.14 g/kg.h for fat emulsion clearance test: and in Group 2, the dose was 0.06 g/kg.h for total parenteral nutrition (TPN) support. The beta-hydroxybutyrate concentrations were estimated by an enzymatic method using Sigma's beta-hydroxybutyrate kit (Sigma Diagnostics, MO 63178, USA). The normal range of beta-hydroxybutyrate concentration in 30 healthy Chinese subjects was 1.04 +/- 1.42 mg/dl (range 0-3.88 mg/dl). In Group 1, we found that the concentrations of beta-hydroxybutyrate rose steadily after fat emulsion infusion. The concentrations in the medium chain triglyceride group were higher than those in long chain triglyceride group. The elevated concentrations of beta-hydroxybutyrate gradually returned to normal levels when the emulsion infusion was stopped. In Group 2, the concentrations of beta-hydroxybutyrate in the patients were within the normal range.
Yang
N
N
PUMC Hospital, Beijing.
Jiang
Z
Z
D020155:3-Hydroxybutyric Acid; D000328:Adult; D005217:Fat Emulsions, Intravenous / Q000008:administration & dosage*; D005260:Female; D005743:Gastrectomy; D006801:Humans; D006885:Hydroxybutyrates / Q000097:blood*; D007657:Ketone Bodies / Q000097:blood*; D008297:Male; D008657:Metabolic Clearance Rate; D008875:Middle Aged; D010289:Parenteral Nutrition, Total; D011184:Postoperative Period; D013514:Surgical Procedures, Operative; D014280:Triglycerides / Q000008:administration & dosage* / Q000493:pharmacokinetics
D005217:Fat Emulsions, Intravenous; D006885:Hydroxybutyrates; D007657:Ketone Bodies; D014280:Triglycerides; D020155:3-Hydroxybutyric Acid