title: Developmental regulation of class I major histocompatibility complex antigen expression by equine trophoblastic cells.
abstract: Between days 36-38 of pregnancy equine trophoblastic cells of the chorionic girdle migrate and form endometrial cups. Just prior to invasion, the chorionic girdle cells express high levels of polymorphic, paternally inherited, major histocompatibility complex (MHC) class I antigens. Their descendents, the mature, invasive trophoblast cells of the endometrial cups, however, express low or undetectable levels of MHC class I antigens by day 44 of pregnancy. Experiments with MHC compatible pregnancies, the study of residual chorionic girdle cells that had failed to invade the endometrium and remained on the surface of a conceptus, and the study of chorionic girdle cells recovered on days 34-36 of pregnancy and then maintained in vitro for up to 24 days strongly suggest that the reduction of MHC class I antigen expression by mature invasive trophoblast cells of the endometrial cups is developmentally regulated. This phenomenon does not appear to be induced by a maternal antibody response or by other uterine factors acting after the chorionic girdle trophoblast cells invade the endometrium.
authors.affiliation: James A. Baker Institute For Animal Health, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853.
authors.forename: W L
authors.initials: WL
authors.lastname: Donaldson
authors.forename: J G
authors.initials: JG
authors.lastname: Oriol
authors.forename: A
authors.initials: A
authors.lastname: Plavin
authors.forename: D F
authors.initials: DF
authors.lastname: Antczak
mesh_terms: D000818:Animals; D002823:Chorion / Q000166:cytology / Q000378:metabolism*; D005314:Embryonic and Fetal Development; D004717:Endometrium / Q000166:cytology / Q000378:metabolism*; D005260:Female; D015395:Histocompatibility Antigens Class I / Q000032:analysis*; D000949:Histocompatibility Antigens Class II / Q000032:analysis*; D006736:Horses / Q000196:embryology*; D011247:Pregnancy; D014327:Trophoblasts / Q000166:cytology / Q000378:metabolism*
chemical_list: D015395:Histocompatibility Antigens Class I; D000949:Histocompatibility Antigens Class II