[Effects of fat intake on immunomodulation in burned patients].
Since fatty acids influence prostaglandins synthesis, and both fatty acids and prostaglandins modulate immune function, we studied the effects of dietary fats on immunomodulation in severely burned patients. We observed that the administration of fish oil can affect immune response after burns, but a high fat intake seemed to markedly reduce the effect. With lower fat intake, fish oil induced a higher mitogenic response of the lymphocyte to PHA and higher blood IgG level in burned patients. These findings suggest that regulation of dietary lipids may play an important role in nutritional support after burn injury.
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Shanghai Burn Institute, Rui Jin Hospital, Shanghai Second Medical University.
D002056:Burns / Q000178:diet therapy* / Q000276:immunology*; D004041:Dietary Fats / Q000008:administration & dosage*; D005395:Fish Oils / Q000008:administration & dosage; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood; D008213:Lymphocyte Activation
D004041:Dietary Fats; D005395:Fish Oils; D007074:Immunoglobulin G