title: Functional deficiency of antigen-presenting cells in the synovial fluid of rheumatoid arthritis.
abstract: In our study of rheumatoid arthritis (RA) patients, we observed a decrease of tetanus toxoid antigen-presenting capacity of synovial fluid (SF) adherent cells to autologous T cells of either SF or peripheral blood. Additionally, we found a higher capacity of adherent synovial cells to stimulate autologous T-lymphocytes. Our results suggest that antigen-presenting cells of the SF of RA patients have defects that may play a role in defective presentation of antigens in joints and may account for other abnormal functions important in the pathogenesis of RA.
authors.affiliation: Dana-Farber Cancer Institute, Boston, Massachusetts 02115.
authors.forename: A
authors.initials: A
authors.lastname: Iglesias
authors.forename: H
authors.initials: H
authors.lastname: Deulofeut
authors.forename: D P
authors.initials: DP
authors.lastname: Dubey
authors.forename: M
authors.initials: M
authors.lastname: Salazar
authors.forename: E
authors.initials: E
authors.lastname: Egea
authors.forename: E J
authors.initials: EJ
authors.lastname: Yunis
authors.forename: P A
authors.initials: PA
authors.lastname: Fraser
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000938:Antigen-Presenting Cells / Q000276:immunology*; D001172:Arthritis, Rheumatoid / Q000188:drug therapy / Q000276:immunology*; D002448:Cell Adhesion / Q000276:immunology; D005260:Female; D006680:HLA Antigens / Q000032:analysis; D006801:Humans; D007111:Immunity, Cellular; D016130:Immunophenotyping; D008213:Lymphocyte Activation / Q000187:drug effects / Q000276:immunology; D008875:Middle Aged; D010835:Phytohemagglutinins / Q000276:immunology; D011043:Pokeweed Mitogens / Q000276:immunology; D011241:Prednisone / Q000494:pharmacology; D013582:Synovial Fluid / Q000166:cytology*; D013601:T-Lymphocytes / Q000276:immunology; D013745:Tetanus Toxoid / Q000276:immunology
chemical_list: D006680:HLA Antigens; D010835:Phytohemagglutinins; D011043:Pokeweed Mitogens; D013745:Tetanus Toxoid; D011241:Prednisone