[Excretion of free catecholamines in urine and activity of some enzymes involved in catecholamine metabolism with arterial hypertension during menopause].
This study was performed in 60 women aged between 47-55 years (mean age 50.46 +/- 1.7), divided into two groups: premenopausal and postmenopausal. Each group was subdivided according to arterial pressure: with normal pressure and arterial hypertension. Daily urinary excretion of catecholamines was determined according to method of Euler and Lishajko, the activity of dopamine--beta-hydroxylase in serum according to Nagatsu et al. The activity of catechol-O-methyltransferase in erythrocytes according to Axelrod et al., the activity monoamineoxidase in serum according to Wurtman et al. Daily urinary excretion of vanilmandelic acid determined according to Pisano et al. It was found that women with menopausal arterial hypertension have significantly greater urinary excretion of adrenaline and noradrenaline (p < 0.001) in the premenopausal period, and adrenaline (p < 0.01) in the postmenopausal period. The activity of dopamine-beta-hydroxylase did not differ from the control group. The activity of COMT in erythrocytes of women and MAO in serum of women with menopausal arterial hypertension was significantly lower. Daily urinary excretion of vanillinmandelic acid in women with menopausal arterial hypertension was significantly lower.
Stanosz
S
S
Kliniki Ginekologii Instytutu Połoznictwa i Ginekologii AM, Szczecinie.
Wasilewska
E
E
D002394:Catechol O-Methyltransferase / Q000097:blood; D002395:Catecholamines / Q000652:urine*; D005260:Female; D006801:Humans; D006973:Hypertension / Q000378:metabolism*; D008593:Menopause / Q000378:metabolism*; D008875:Middle Aged; D008995:Monoamine Oxidase / Q000097:blood
D002395:Catecholamines; D008995:Monoamine Oxidase; D002394:Catechol O-Methyltransferase
Wydalanie wolnych amin katecholowych z moczem i aktywność niektórych enzymów uczestiniczacych w ich przemianie u kobiet z nadciśnieniem tetniczym w okresie przekwitania.