n-3 fatty acids: biochemical actions in cancer.
A number of reports indicate that fish n-3 PUFA inhibit the development, growth and progression of several experimental tumors. There emerges a pattern of complex and diverse biochemical actions of n-3 PUFA in different animal tumor models, from the studies undertaken to date to evaluate the underlying mechanisms. These findings, along with the recent epidemiological evidence of an inverse correlation between fish intake and incidence of some human cancers, makes it worthwhile to determine the role of n-3 PUFA in cancer.
Karmali
R
R
Memorial Sloan-Kettering Cancer Center, New York, New York.
D000818:Animals; D016718:Arachidonic Acid / Q000378:metabolism; D015525:Fatty Acids, Omega-3 / Q000494:pharmacology*; D006801:Humans; D050356:Lipid Metabolism; D009362:Neoplasm Metastasis / Q000517:prevention & control; D009369:Neoplasms / Q000188:drug therapy* / Q000453:epidemiology; D009374:Neoplasms, Experimental / Q000188:drug therapy*; D009955:Ornithine Decarboxylase / Q000187:drug effects
D015525:Fatty Acids, Omega-3; D016718:Arachidonic Acid; D009955:Ornithine Decarboxylase