[Immunohistochemical study of the lymph-follicles and lymphocytes in the gastric mucosa].
Immunohistochemical stainings according to ABC method (UCHL-1,L-26,MT-1,MB-1,IgG,IgA,IgD,IgM, kappa, lambda, LN-1 and LN-2) for the lymphocytes in the germinal center, mantle zone and infiltrative lymphocytes in the gastric mucosa of 30 cases of chronic gastritis and 10 cases of reactive lymphoreticular hyperplasia (RLH) were performed. Lymphocytes in the germinal center and mantle zone consisted usually of B-cells positively stained by L-26 and MB-1. However, in the interstitially infiltrative cells,T-cells positively stained by UCHL-1 and MT-1 were not infrequently contained. Immunoglobulin stainings revealed marked positivity for IgG,IgA,IgD,IgM, kappa and lambda in the interstitial lymphocytes and plasma cells. As to the RLH, small number of T-cells scattered in the germinal center and surrounding area of lymph follicles, and large number of T-cells were found among the follicles, where B-cells were more infrequently found than in the interstitial area of propria mucosae. Confusion of enlarged germinal centers and monotonous proliferation of lymphocytes among the lymph follicles showing monotonous positivity for the stains of heavy and light chains in the cases of RLH were suggestive of malignant change.
Yamagiwa
H
H
Department of Pathology, Mie University Hospital.
Onishi
N
N
Onishi
T
T
Onishi
T
T
Oishi
M
M
Satomoto
K
K
Nishii
M
M
D002908:Chronic Disease; D005753:Gastric Mucosa / Q000473:pathology*; D005756:Gastritis / Q000473:pathology; D006801:Humans; D006965:Hyperplasia; D007136:Immunoglobulins / Q000032:analysis; D007150:Immunohistochemistry; D008214:Lymphocytes / Q000473:pathology*
D007136:Immunoglobulins