Evaluation of mutagenic, genotoxic and transforming properties of Ukrain.
Evaluation of mutagenic and genotoxic properties of Ukrain was on the basis of the Ames and micronucleus tests. Ukrain was investigated for its ability to induce morphological transformation of embryonic cells of the Syrian hamster. Under the experimental condition used in this study, Ukrain was found to be non-mutagenic and non-genotoxic, and furthermore did not induce morphological cell transformation.
Chłopkiewicz
B
B
Drug Institute, Warsaw, Poland.
Marczewska
J
J
Ejchart
A
A
Anuszewska
E
E
Koziorowska
J
J
D000470:Alkaloids / Q000493:pharmacokinetics / Q000633:toxicity*; D000818:Animals; D001600:Berberine Alkaloids; D001711:Biotransformation; D002471:Cell Transformation, Neoplastic / Q000139:chemically induced*; D002478:Cells, Cultured; D006224:Cricetinae; D005260:Female; D066298:In Vitro Techniques; D008647:Mesocricetus; D015162:Micronucleus Tests; D009152:Mutagenicity Tests; D009153:Mutagens / Q000493:pharmacokinetics / Q000633:toxicity*; D010617:Phenanthridines; D011247:Pregnancy; D051381:Rats; D011921:Rats, Inbred WKY; D012486:Salmonella typhimurium / Q000187:drug effects / Q000235:genetics
D000470:Alkaloids; D001600:Berberine Alkaloids; D009153:Mutagens; D010617:Phenanthridines; C060921:ukrain