[Lipid and lipoprotein profile in psoriasis].
Psoriasis is a common relapsing dermatosis characterized by an increased epidermal cell proliferation. In this work we studied the lipid and lipoprotein pattern in 17 patients affected by long-standing psoriasis and in 20 normal controls. Total cholesterol, triglyceride, HDL-cholesterol and Apolipoprotein AI and B levels were measured; VLDL, LDL and HDL chemical composition was assessed by preparative ultracentrifugation. Plasma lipid and lipoprotein levels were significantly lower in the patient group; chemical analysis of the main lipoprotein classes showed compositional abnormalities consistent with an accelerated turnover of these particles. We believe that epidermal cell proliferation can play a role in determining these changes.
Deiana
L
L
Cattedra di Biochimica Clinica, Facoltà di Medicina, Università degli Studi di Sassari.
Pes
G M
GM
Carru
C
C
Tidore
M
M
Cherchi
G M
GM
D000293:Adolescent; D000328:Adult; D000368:Aged; D005260:Female; D006801:Humans; D015603:Keratinocytes / Q000378:metabolism; D008055:Lipids / Q000097:blood*; D008074:Lipoproteins / Q000097:blood*; D008297:Male; D008875:Middle Aged; D011565:Psoriasis / Q000097:blood*
D008055:Lipids; D008074:Lipoproteins
Assetto lipidico e lipoproteico nella psoriasi.