[Carcinogenesis induced by the neonatal administration of 5-bromo-2'-deoxyuridine and subsequent exposure to N-nitrosomethylurea in rats].
Shorter life span, higher frequency and multiplicity of tumor, and shorter latency period as compared with intact controls were observed in LIO rats, which were injected, sc, 3.2 mg 5-bromo-2-deoxyuridine (BrdU)--a synthetic analog of thymidine--at days 1, 3, 7 and 21 after birth. Single intravenous injection of 50 mg/kg N-nitrosomethylurea (NMU) into 3 month-old rats treated neonatally with BrdU was followed by a significant increase in the frequency and multiplicity of tumors of certain localizations matched by a shorter latency period as compared with rats pretreated with either BrdU or NMU alone. It is suggested that BrdU-induced damage to DNA is sufficient for initiation and development of tumor growth and raising the level of sensitivity to other carcinogenic agents.
Osipova
G Iu
GIu
Anisimov
V N
VN
D000375:Aging / Q000187:drug effects; D000818:Animals; D000831:Animals, Newborn; D001973:Bromodeoxyuridine / Q000008:administration & dosage / Q000633:toxicity*; D004347:Drug Interactions; D005260:Female; D015993:Life Tables; D008297:Male; D008770:Methylnitrosourea / Q000008:administration & dosage / Q000633:toxicity*; D009374:Neoplasms, Experimental / Q000139:chemically induced* / Q000401:mortality; D051381:Rats; D012737:Sex Factors
D008770:Methylnitrosourea; D001973:Bromodeoxyuridine
Kantserogenez, indutsirovannyĭ neonatal'nym vvedeniem 5-brom-2'-dezoksiuridina i posleduiushchim vozdeĭstviem N-nitrozometilmocheviny u krys.