Modification of antinociceptive action of morphine by Ukrain in rodents.
Morphine-induced (0.1 mg/kg s.c.)antinociceptive action was determined in rodents by using the writhing syndrome, hot plate and tail-flick tests. Ukrain given i.p. in doses equivalent to 0.05 and 0.1 LD50 did not affect the reactivity of the mice in the writhing syndrome test. Only in a dose of 0.1 LD50 did Ukrain produce an antinociceptive effect in the hot-plate and tail-flick tests. Ukrain significantly enhanced the antinociceptive effect of morphine in the hot-plate and tail-flick tests. The action of morphine was significantly suppressed by Ukrain in the writhing syndrome test in mice. These results indicated that Ukrain modified the antinociceptive action of morphine.
Jagiełło-Wójtowicz
E
E
Department of Pharmacology, Medical Academy, Lublin, Poland.
Kleinrok
Z
Z
Chodkowska
A
A
Feldo
M
M
Nowicky
J W
JW
D000085:Acetates; D019342:Acetic Acid; D000470:Alkaloids / Q000494:pharmacology*; D000700:Analgesics / Q000494:pharmacology*; D000818:Animals; D001600:Berberine Alkaloids; D004357:Drug Synergism; D008297:Male; D051379:Mice; D009020:Morphine / Q000494:pharmacology*; D010146:Pain / Q000139:chemically induced; D010147:Pain Measurement / Q000187:drug effects; D010617:Phenanthridines; D051381:Rats; D017208:Rats, Wistar; D011930:Reaction Time / Q000187:drug effects
D000085:Acetates; D000470:Alkaloids; D000700:Analgesics; D001600:Berberine Alkaloids; D010617:Phenanthridines; C060921:ukrain; D009020:Morphine; D019342:Acetic Acid