[The efficacy of substances with antihypoxic action in experimental hyperlipidemia].
Experiments on rats, guinea pigs and rabbits with hyperlipidemia induced by high-cholesterol diet have revealed that the specific antihypoxic drug oliphen has hypolipidemic effect which is least pronounced in oral GABA. Oliphen causes a significant increase in alpha-cholesterol (antiatherogenic lipoprotein cholesterol) decreased by hyperlipidemia. It is suggested that oliphen improves hepatic receptor-dependent uptake and atherogenic lipoprotein degradation.
Ryzhenkov
V E
VE
Remezova
O V
OV
Triufanov
V F
VF
Vasil'eva
L E
LE
D000818:Animals; D002791:Cholesterol, Dietary / Q000008:administration & dosage; D002994:Clofibrate / Q000627:therapeutic use; D004353:Drug Evaluation, Preclinical; D006168:Guinea Pigs; D006949:Hyperlipidemias / Q000097:blood / Q000188:drug therapy* / Q000209:etiology; D000960:Hypolipidemic Agents / Q000627:therapeutic use*; D008055:Lipids / Q000097:blood; D008297:Male; D011817:Rabbits; D051381:Rats; D005680:gamma-Aminobutyric Acid / Q000627:therapeutic use*
D002791:Cholesterol, Dietary; D000960:Hypolipidemic Agents; D008055:Lipids; D005680:gamma-Aminobutyric Acid; D002994:Clofibrate
Effektivnost' veshchestv antigipoksicheskogo deĭstviia pri éksperimental'noĭ giperlipidemii.