title: Towards a malaria vaccine: riding the rollercoaster between unrealistic optimism and lethal pessimism.
abstract: Activity in many laboratories over the past decade has resulted in many vaccine candidates nearing clinical trials. These include several antigens from the sporozoite stage; merozoite surface antigens MSA1 and MSA2, RESA, the rhoptry proteins RAP-1 and RAP-2 from the asexual blood stage; the pfs25, pfg45 and pfg230 from the ookinete and gamete stages. This progress in the identification of potential vaccine candidates now highlights a series of scientific, developmental, economic and operational problems the solutions to which will be as critical to the development of a vaccine as the cloning and expression of parasite genes.
authors.affiliation: Tropical Health Program, Queensland Institute of Medical Research, Brisbane, Australia.
authors.forename: A
authors.initials: A
authors.lastname: Saul
mesh_terms: D000818:Animals; D006801:Humans; D008288:Malaria / Q000276:immunology / Q000517:prevention & control*; D010961:Plasmodium / Q000187:drug effects / Q000276:immunology*; D016052:Protozoan Vaccines / Q000276:immunology / Q000494:pharmacology
chemical_list: D016052:Protozoan Vaccines