The study of G6PD in erythrocyte and lens in senile and presenile cataract.
The G6PD activity of erythrocytes in 113 male patients with senile and presenile cataract and 86 controls, and G6PD activity of lens in 30 patients with senile cataract and 42 controls were reported. The cataractous group had higher frequency of G6PD deficiency and lower average G6PD level in erythrocytes and lenses, but without statistical significance. The frequency of G6PD deficiency of erythrocytes in presenile cataractous group was higher than that of senile cataractous group but with no statistical significance too. However, the average G6PD level of erythrocytes in presenile cataractous group was lower than that of senile cataractous group and with statistical significance (P < 0.05). The G6PD activity of lenses only presenile in the cortex and have a positive correlation with that of erythrocytes. There was a case with deficiency of G6PD both of erythrocytes and cataractous lenses in both eyes. The results indicate that the deficiency of G6PD might be one of the cataractous pathogenetic factor for presenile cataract. Measurement of G6PD activity of erythrocytes among population might be of significance in finding the risk factor for cataract.
Chen
Y
Y
Eye Research Institute, Sun Yat-Sen University of Medical Sciences Guangzhou, China.
Zeng
L
L
Ma
Q
Q
Su
W
W
Mao
W
W
D000328:Adult; D000368:Aged; D002386:Cataract / Q000145:classification / Q000201:enzymology* / Q000209:etiology; D004912:Erythrocytes / Q000201:enzymology*; D005954:Glucosephosphate Dehydrogenase / Q000378:metabolism*; D005955:Glucosephosphate Dehydrogenase Deficiency / Q000150:complications; D006801:Humans; D007908:Lens, Crystalline / Q000201:enzymology*; D008297:Male; D008875:Middle Aged; D012307:Risk Factors
D005954:Glucosephosphate Dehydrogenase