[The stimulation of the delayed hypersensitivity reaction by the venom of the blunt-nosed viper Vipera lebetina and by its liposomal form].
Native poison of middleasia viper Vipera lebetina has been included into liposomes in order to get an effective preparation for immunotherapy. The preparation reduces the risk of complications taking place during the use of traditional methods. The immunomodulating action of the liposomal form of viper poison has been investigated on the model of reaction of hypersensitivity of delayed type. Together with the stimulation of functional activity T-cells, the absence of suppressive and toxic actions while using the liposomal preparation of poison has been discovered. It is suggested that the observed stimulating effect in connection with immune reactions is due to synergism of action of components of poison liposomal form and activation of T-cells and macrophage, taking part in immune response to the antigenic stimulus.
Romanova
E B
EB
Gelashvili
D B
DB
Fedorov
O T
OT
D000818:Animals; D004337:Drug Carriers; D006968:Hypersensitivity, Delayed / Q000209:etiology* / Q000276:immunology; D007111:Immunity, Cellular / Q000187:drug effects; D007114:Immunization; D008081:Liposomes; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D013268:Stimulation, Chemical; D014757:Viper Venoms / Q000494:pharmacology*
D004337:Drug Carriers; D008081:Liposomes; D014757:Viper Venoms
Stimuliatsiia reaktsii giperchuvstvitel'nosti zamedlennogo tipa iadom sredneaziatskoĭ giurzy Vipera lebetina i ego liposomnoĭ formoĭ.