title: Reduced growth of Lucilia cuprina larvae fed serum from sheep treated with anthelmintics.
abstract: The effect of three commonly used anthelmintics, levamisole hydrochloride, ivermectin and closantel, on the development of the sheep blowfly, Lucilia cuprina, was determined. Sheep were treated with each anthelmintic using the manufacturers' recommended dose for helminth control. Both ivermectin and closantel significantly (p < 0.05) reduced the growth rate of larvae of L cuprina cultured in vitro on serum from these sheep. Levamisole hydrochloride had no effect. Ivermectin was effective for less than 6 days after treatment, whereas closantel significantly reduced larval growth 21 days after treatment. Dose-response experiments showed that lower concentrations of both ivermectin and closantel were not as effective in reducing larval growth.
authors.affiliation: CSIRO Division of Tropical Animal Production, Long Pocket Laboratories, Indooroopilly, Queensland.
authors.forename: I J
authors.initials: IJ
authors.lastname: East
authors.forename: R L
authors.initials: RL
authors.lastname: Kerlin
authors.forename: C H
authors.initials: CH
authors.lastname: Eisemann
mesh_terms: D000818:Animals; D004175:Diptera / Q000254:growth & development; D004305:Dose-Response Relationship, Drug; D005260:Female; D007559:Ivermectin / Q000097:blood; D007814:Larva / Q000254:growth & development; D007978:Levamisole / Q000097:blood; D012458:Salicylanilides / Q000097:blood; D012756:Sheep / Q000097:blood*
chemical_list: D012458:Salicylanilides; D007978:Levamisole; D007559:Ivermectin; C023342:closantel