title: Modulation of adenylate cyclase signalling.
abstract: Adenylate cyclase via production of cyclic AMP (cAMP) can transduce dual signals, positive and negative, on cell growth and differentiation. Such dual signals are transmitted by RI and RII cAMP-binding receptor proteins respectively, the regulatory subunits of cAMP dependent protein kinases. The growth stimulatory RI and inhibitory RII are in a strict balance to maintain normal cells, and departure from such balance can cause a great variety of human diseases, including cancer. Experimental approaches using site-selective cAMP analogues, antisense oligodeoxynucleotides, and gene transfer have shown that restoration of the normal balance of RI/RII provides a biological means to the suppression of malignancy.
authors.affiliation: Laboratory of Tumor Immunology and Biology, National Cancer Institute, Bethesda, MD 20892.
authors.forename: Y S
authors.initials: YS
authors.lastname: Cho-Chung
mesh_terms: D000262:Adenylyl Cyclases / Q000187:drug effects* / Q000502:physiology; D000970:Antineoplastic Agents / Q000494:pharmacology*; D006801:Humans; D015398:Signal Transduction / Q000187:drug effects*
chemical_list: D000970:Antineoplastic Agents; D000262:Adenylyl Cyclases