title: Cytogenetic findings in three primary hepatocellular carcinomas.
abstract: Short-term cultures of three primary hepatocellular carcinomas were cytogenetically analyzed. Case 1 displayed a normal karyotype. Case 2 had, in addition to cells with a normal male chromosome complement, a clone with -Y. In case 3, two abnormal clones were found, one with -Y and one with a highly aberrant karyotype: [formula: see text] Our results, collated with the findings in one previously published primary hepatocellular carcinoma and in three cell lines, suggest that structural changes of chromosomes 1 and 6, leading to loss of 1p and 6q material, and loss of chromosome 16 are frequent events in hepatocellular carcinogenesis.
authors.affiliation: Department of Clinical Genetics, Lund University Hospital, Sweden.
authors.forename: G
authors.initials: G
authors.lastname: Bardi
authors.forename: B
authors.initials: B
authors.lastname: Johansson
authors.forename: N
authors.initials: N
authors.lastname: Pandis
authors.forename: S
authors.initials: S
authors.lastname: Heim
authors.forename: N
authors.initials: N
authors.lastname: Mandahl
authors.forename: A
authors.initials: A
authors.lastname: Andrén-Sandberg
authors.forename: I
authors.initials: I
authors.lastname: Hägerstrand
authors.forename: F
authors.initials: F
authors.lastname: Mitelman
mesh_terms: D000368:Aged; D006528:Carcinoma, Hepatocellular / Q000235:genetics* / Q000473:pathology* / Q000601:surgery; D002460:Cell Line; D002869:Chromosome Aberrations; D006801:Humans; D007621:Karyotyping; D008099:Liver / Q000473:pathology; D008113:Liver Neoplasms / Q000235:genetics* / Q000473:pathology* / Q000601:surgery; D008297:Male; D014407:Tumor Cells, Cultured