[Exposure level of N-nitrosamines in the gastric juice and its inhibition by vitamin C in high risk areas of esophageal cancer].
A total of 391 gastric juice samples was collected from Ji Yuan and An Shi counties, high and medium risk areas of esophageal carcinoma in Henan province. NDMA, NDEA, NMBzA, NPip and unknown compounds were assayed in the fasting gastric juice. Among these nitrosamines, NMBzA, NPyr and NPip were specific in inducing esophageal cancer in animals. The amount of nitrosamines in the gastric juice collected from Ji Yuan county was higher than that from An Shi county. The exposure level of nitrosamines of subjects from these two localities were significantly different (P < 0.001). There was a positive relationship between the nitrosamines exposure level and esophageal cancer mortality rate. The amount of gastric N-nitrosamines from An Shi subjects as treated with vitamin C was reduced. It is evident that vitamin C can inhibit N-nitrosamine formation in the stomach, thereby, reducing the N-nitrosamines exposure level.
Yang
W X
WX
Henan Cancer Institute, Zhengzhou.
D000328:Adult; D000368:Aged; D001205:Ascorbic Acid / Q000494:pharmacology*; D004128:Dimethylnitrosamine / Q000031:analogs & derivatives / Q000032:analysis; D004938:Esophageal Neoplasms / Q000737:chemistry*; D004947:Esophagus / Q000473:pathology; D005260:Female; D005750:Gastric Juice / Q000737:chemistry*; D006801:Humans; D006965:Hyperplasia; D008297:Male; D008875:Middle Aged; D009242:N-Nitrosopyrrolidine / Q000032:analysis; D009602:Nitrosamines / Q000032:analysis* / Q000037:antagonists & inhibitors; D011230:Precancerous Conditions / Q000737:chemistry
D009602:Nitrosamines; C014707:nitrosobenzylmethylamine; D004128:Dimethylnitrosamine; D001205:Ascorbic Acid; D009242:N-Nitrosopyrrolidine