[Effectiveness of phosphomycin and its combinations with amikacin and cefotaxime in experimental plague infection].
When administered intramuscularly in doses of 8 and 16 mg/mouse, phosphomycin was highly active in the treatment of albino mice with experimental plague infection (80-100-percent protection of the animals from death). Combinations of phosphomycin with cefotaxime in inefficient or not sufficiently efficient doses had a synergistic effect. When the albino mice were treated with combinations of phosphomycin and amikacin, the percentage of the survived animals significantly increased in comparison to that after the use of the antibiotics alone.
Shcherbaniuk
A I
AI
Kasatkina
I V
IV
Makarovskaia
L N
LN
D000583:Amikacin / Q000008:administration & dosage; D000818:Animals; D002439:Cefotaxime / Q000008:administration & dosage; D004357:Drug Synergism; D004359:Drug Therapy, Combination / Q000627:therapeutic use*; D005578:Fosfomycin / Q000627:therapeutic use; D007273:Injections, Intramuscular; D051379:Mice; D010930:Plague / Q000188:drug therapy*
D005578:Fosfomycin; D000583:Amikacin; D002439:Cefotaxime
Izuchenie éffektivnost' fosfomitsina i ego sochetaniĭ s amikatsinom i tsefotaksimom pri éksperimental'noĭ chumnoĭ infektsii.