[Tumor necrosis factor-alpha and interleukin-1beta in the blood plasma of patients with HIV infection].
The paper presents examination findings of 67 HIV-infected patients: 32 children aged 2.5 to 16 years and 35 adults aged 21 to 46 years. The proportion of patients with higher alpha-tumor necrosis factor and interleukin-1 beta increased with progression of the disease, the two parameters being higher in the children than in the adults. A correlation was found between the appearance of cytokines in the plasma and some clinical signs, such as fever, weight loss, anemia, neurological disorders. A parallel study of the patients' immunograms indicated significant correlations between the degree of impairments in the composition of lymphocyte subpopulations and the appearance of plasma cytokines.
Ketlinskiĭ
S A
SA
Kalinina
N M
NM
Tsvetkova
S N
SN
Rakhmanova
A G
AG
Maslov
V N
VN
Khaldeeva
N A
NA
D000163:Acquired Immunodeficiency Syndrome / Q000097:blood* / Q000175:diagnosis / Q000276:immunology; D000293:Adolescent; D000328:Adult; D000367:Age Factors; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007124:Immunoenzyme Techniques; D007375:Interleukin-1 / Q000032:analysis*; D053583:Interleukin-1beta; D007958:Leukocyte Count; D008214:Lymphocytes / Q000276:immunology; D008297:Male; D008875:Middle Aged; D010446:Peptide Fragments / Q000032:analysis*; D012720:Severity of Illness Index; D014409:Tumor Necrosis Factor-alpha / Q000032:analysis*
D007375:Interleukin-1; D053583:Interleukin-1beta; D010446:Peptide Fragments; D014409:Tumor Necrosis Factor-alpha; C052994:interleukin-1beta (163-171)
Faktor nekroza opukholi-alpha i interleĭkin-1beta v plazme krovi bol'nykh VICh-infektsieĭ.