title: Heterogeneity of the radiosensitivity and origins of tissue macrophage colony-forming cells.
abstract: Previous studies suggest that the radiosensitivity and origin of tissue macrophage precursors differ from those of hemopoietic macrophage colony-forming units (CFU-Ms) committed to macrophage-lineage cells. We assessed the origins of tissue macrophage colony-forming cells (M-CFCs) in mice by comparing their kinetics and radiosensitivities in the normal steady state and under the conditions of bone marrow depletion by 89Sr-administration and/or splenectomy. The results indicate that the radiosensitive peritoneal M-CFCs elicited by thioglycollate are derived from bone marrow macrophage precursors; where as alveolar M-CFCs, which are radioresistant, are self-sustained locally and independent of hemopoietic macrophage precursors. In contrast, highly radiosensitive liver M-CFCs are probably derived from CFU-Ms that appear to be propagated in the spleen in association with hemopoietic responses.
authors.affiliation: Division of Comparative Radiotoxicology, National Institute of Radiological Sciences, Chiba, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Oghiso
authors.forename: Y
authors.initials: Y
authors.lastname: Yamada
mesh_terms: D000818:Animals; D001853:Bone Marrow / Q000528:radiation effects; D001854:Bone Marrow Cells; D005260:Female; D008264:Macrophages / Q000166:cytology*; D051379:Mice; D008809:Mice, Inbred C3H; D011836:Radiation Tolerance / Q000502:physiology*; D013234:Stem Cells / Q000166:cytology*; D013326:Strontium Radioisotopes
chemical_list: D013326:Strontium Radioisotopes