Amino acids and peptides. XVI. Synthesis of N-terminal tetrapeptide analogs of fibrin alpha-chain and their inhibitory effects on fibrinogen/thrombin clotting.
N-Terminal tetrapeptide analogs of fibrin alpha-chain were synthesized by the solution method using a new active ester, the ester of the oxime of p-nitroacetophenone, and by the solid-phase method. Their inhibitory effects on fibrinogen/thrombin clotting were examined. Of the synthetic peptides, amide analogs of Gly-Pro-Arg-Pro exhibited a more potent inhibitory effect.
Kawasaki
K
K
Faculty of Pharmaceutical Sciences, Kobe-Gakuin University, Japan.
Hirase
K
K
Miyano
M
M
Tsuji
T
T
Iwamoto
M
M
D000595:Amino Acid Sequence; D000925:Anticoagulants / Q000138:chemical synthesis* / Q000494:pharmacology*; D001777:Blood Coagulation / Q000187:drug effects*; D005340:Fibrinogen / Q000037:antagonists & inhibitors*; D005344:Fibrinopeptide A / Q000138:chemical synthesis* / Q000494:pharmacology*; D006801:Humans; D008969:Molecular Sequence Data; D009842:Oligopeptides / Q000138:chemical synthesis* / Q000494:pharmacology*; D010446:Peptide Fragments / Q000138:chemical synthesis / Q000494:pharmacology; D011487:Protein Conformation; D013329:Structure-Activity Relationship; D013917:Thrombin / Q000037:antagonists & inhibitors*
D000925:Anticoagulants; D009842:Oligopeptides; D010446:Peptide Fragments; D005344:Fibrinopeptide A; D005340:Fibrinogen; D013917:Thrombin