[The immunostimulating properties of cholecystokinin octapeptide and its fragments].
Immunostimulating properties of cholecystokinin octapeptide (CCK-8) were evaluated in experiments on adult normal and thymectomized mice, in vitro. It was shown that CCK-8 stimulates IgM-PFC production to SRBC, but does not change the immune response to Vi-antigen. CCK-8 increases the number of Thy-I+ spleen T cells and restores thymus-dependent immune response in thymectomized mice. CCK-8 has no effect on neutrophil phagocytosis activity in vitro. The immunostimulating activity of CCK-8 is related mainly to C-terminal fragment (identical to pentagastrin tetrapeptide) since the N-terminal CCK-8 tetrapeptide displays negligible effect in all tests.
Molchanova
I V
IV
Belokrylov
G A
GA
Popova
O Ia
OIa
Kalikhevich
V N
VN
D000276:Adjuvants, Immunologic / Q000494:pharmacology*; D000818:Animals; D004305:Dose-Response Relationship, Drug; D004912:Erythrocytes / Q000187:drug effects / Q000276:immunology; D008297:Male; D051379:Mice; D008808:Mice, Inbred CBA; D010446:Peptide Fragments / Q000494:pharmacology*; D010587:Phagocytosis / Q000187:drug effects; D012844:Sincalide / Q000494:pharmacology*; D013154:Spleen / Q000187:drug effects / Q000276:immunology; D013329:Structure-Activity Relationship; D013601:T-Lymphocytes / Q000187:drug effects / Q000276:immunology; D013934:Thymectomy
D000276:Adjuvants, Immunologic; D010446:Peptide Fragments; D012844:Sincalide
Immunostimuliruiushchie svoĭstva oktapeptida kholetsistokinina i ego fragmentov.