title: [ Combined therapy with isosorbide dinitrate, propranolol and nifedipine in patients with chronic ischemic heart disease].
abstract: Forty six patients with stable effort angina were treated with a combination of propranolol, nifedipine, and isosorbide dinitrate which produced a more profound anti-antianginal effect than each of them given alone. The combination also exerted more marked antihypertensive and antiarrhythmic effects. The combined therapy with the three drugs caused a moderate reduction in heart rate and peripheral resistance, but failed to result in clear-cut disturbances in the orthostatic regulation of the circulatory system. There was a more infrequent and less pronounced ST-segment depression, less marked pressor responses and higher heart rate with the combined therapy during exercise; the cardiac index also increased as before therapy. Physical fitness increased to a greater extent than with monotherapy. The combined therapy with three drugs is indicated when monotherapy fails and that with two agents is indicated when patients have concurrent essential hypertension and cardiac arrhythmias.
authors.forename: G A
authors.initials: GA
authors.lastname: Glezer
authors.forename: N P
authors.initials: NP
authors.lastname: Moskalenko
authors.forename: V A
authors.initials: VA
authors.lastname: Gaponenko
authors.forename: A S
authors.initials: AS
authors.lastname: Stoliarov
authors.forename: R A
authors.initials: RA
authors.lastname: Saitova
authors.forename: T E
authors.initials: TE
authors.lastname: Simbirina
authors.forename: D Iu
authors.initials: DIu
authors.lastname: Neĭman
authors.forename: O N
authors.initials: ON
authors.lastname: Chilikina
authors.forename: M G
authors.initials: MG
authors.lastname: Akhmetova
authors.forename: A B
authors.initials: AB
authors.lastname: Babaev
mesh_terms: D000328:Adult; D000368:Aged; D000787:Angina Pectoris / Q000188:drug therapy / Q000503:physiopathology; D002908:Chronic Disease; D004359:Drug Therapy, Combination; D006339:Heart Rate / Q000187:drug effects; D006439:Hemodynamics / Q000187:drug effects; D006801:Humans; D007548:Isosorbide Dinitrate / Q000494:pharmacology / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D017202:Myocardial Ischemia / Q000188:drug therapy* / Q000503:physiopathology*; D009543:Nifedipine / Q000494:pharmacology / Q000627:therapeutic use*; D005082:Physical Exertion; D011433:Propranolol / Q000494:pharmacology / Q000627:therapeutic use*; D012146:Rest; D014655:Vascular Resistance / Q000187:drug effects
chemical_list: D011433:Propranolol; D009543:Nifedipine; D007548:Isosorbide Dinitrate
vernacular_title: Primenenie kombinirovannoĭ terapii izosorbida dinitratom, propranololom i nifedipinom u bolńykh khronicheskoĭ ishemicheskoĭ bolezníu serdtsa.