[The effect of negatively charged liposomes on thrombocyte aggregation induced by ADP].
The incubation of platelet-rich plasma of rats with liposomes has changed cell functional activity. Lipid composition of liposomes modulated the ability of the platelets to respond to ADP. Vesicles, containing phosphatidylserine, phosphatidylinositol or stearylamine inhibited the aggregation by 70, 30 and 40%, respectively. The inhibition of aggregation by phosphatidylserine-containing liposomes was of linear and dose-dependent character. The maximal inhibition was reported at 10-min incubation of liposomes with platelets. The impairment of platelets aggregation can be explained by interactions of liposomes with plasma coagulation factors and blocking the receptors on the platelets membranes.
Zakrevskiĭ
V I
VI
Rud'ko
I A
IA
Kubatiev
A A
AA
D000244:Adenosine Diphosphate / Q000494:pharmacology*; D000818:Animals; D004305:Dose-Response Relationship, Drug; D004337:Drug Carriers; D004563:Electrochemistry; D008081:Liposomes; D008297:Male; D010743:Phospholipids / Q000008:administration & dosage / Q000494:pharmacology*; D010974:Platelet Aggregation / Q000187:drug effects*; D051381:Rats; D017208:Rats, Wistar; D013997:Time Factors
D004337:Drug Carriers; D008081:Liposomes; D010743:Phospholipids; D000244:Adenosine Diphosphate
Vliianie otritsatel'no zarazhennykh liposom na agregatsiiu trombotsitov, indutsirovannuiu ADF.