[Chronic neutrophilic leukemia associated with myeloma. Simultaneous presentation].
A case of chronic neutrophilic leukaemia associated with multiple myeloma is reported. The patient had a 6 months history of bruising and weight loss, and showed mature neutrophilic leukocytosis, hepatosplenomegaly, high neutrophil alkaline phosphatase score, hyperuricaemia, neutrophils with pseudotoxic granulation and scarce Döhle bodies; moreover, a monoclonal IgG lambda was detected amounting 57.3 g/L. The bone marrow was grossly hypercellular with marked myeloid hyperplasia and aggregates of immature plasma cells. After treatment during 1 year with melphalan and prednisone she is well, although persisting with neutrophilic leukocytosis, slight splenomegaly, and the monoclonal IgG decreased to 25.8 g/L.
Diéguez
J C
JC
Servicio de Hematología y Hemoterapia, Hospital General de Huelva.
Fernández Jurado
A
A
Amián
A
A
Rodríguez
J N
JN
Martino
M L
ML
Cañavate
M
M
Prados
D
D
D001853:Bone Marrow / Q000473:pathology; D005260:Female; D006801:Humans; D015994:Incidence; D015467:Leukemia, Neutrophilic, Chronic / Q000150:complications* / Q000453:epidemiology / Q000235:genetics / Q000473:pathology; D008875:Middle Aged; D009101:Multiple Myeloma / Q000150:complications* / Q000235:genetics / Q000473:pathology; D010950:Plasma Cells / Q000473:pathology
Leucemia neutrofílica crónica asociada a mieloma. Presentación simultánea.