title: A case of skin hyperpigmentation due to alpha-MSH hypersecretion.
abstract: A case is presented of generalized skin hyperpigmentation due to alpha-MSH hypersecretion from the pituitary that was most marked in the light-exposed areas. The patient also had secondary adrenal dysfunction, peripheral lymphadenopathy, streptococcal glomerulonephritis and malabsorption. Analysis of this patient's alpha-MSH using high-pressure liquid chromatography (HPLC) showed a novel acetylation profile compared to normal individuals and to patients with Cushing's disease and Nelson's syndrome. Glucocorticoid replacement therapy resulted in suppression of alpha-MSH hypersecretion and complete resolution of the illness.
authors.affiliation: Department of Medicine, University of Dundee Medical School, Ninewells Hospital, U.K.
authors.forename: J S
authors.initials: JS
authors.lastname: Pears
authors.forename: R T
authors.initials: RT
authors.lastname: Jung
authors.forename: W
authors.initials: W
authors.lastname: Bartlett
authors.forename: M C
authors.initials: MC
authors.lastname: Browning
authors.forename: K
authors.initials: K
authors.lastname: Kenicer
authors.forename: A J
authors.initials: AJ
authors.lastname: Thody
mesh_terms: D002851:Chromatography, High Pressure Liquid; D006801:Humans; D006854:Hydrocortisone / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged; D010859:Pigmentation Disorders / Q000097:blood / Q000188:drug therapy / Q000209:etiology*; D010902:Pituitary Gland / Q000378:metabolism; D000521:alpha-MSH / Q000097:blood / Q000378:metabolism*
chemical_list: D000521:alpha-MSH; D006854:Hydrocortisone