[Effect of glutamine and glutamine-dipeptide enriched amino acid solution on rat small bowel mucosa regeneration].
To mine the effects of glutamine and it's dipeptide enriched nutrition solution on the gastro-intestinal structure and protein metabolism, 40 male Wistar rats were studied for 8 days. The rats were randomly divided into four groups: sham operation group, standard amino acid solution group, glutamine enriched group and glutamine dipeptide enriched group. Observation parameters were: weight change; serum AA profile analysis; computerized morphometric analysis of mucosa thickness and villus height; total nitrogen balance; and liver, kidney functional results. The data were managed by multiple sample comparison methods (ANOVA of Statview 512 software) on Macintosh PC. Significant level was put on P < 0.05. The results showed that significant differences of body weight, serum glutamine level, nitrogen balance, intestinal mucosa thickness and villus height were found between the control and study groups. No significant difference in liver and kidney function was found. Gln-Ala dipeptide had same effects as free glutamine did.
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Peking Union Medical College Hospital, Beijing.
D000596:Amino Acids / Q000008:administration & dosage / Q000097:blood; D000818:Animals; D004151:Dipeptides / Q000008:administration & dosage / Q000494:pharmacology*; D005973:Glutamine / Q000008:administration & dosage / Q000494:pharmacology*; D007413:Intestinal Mucosa / Q000187:drug effects* / Q000473:pathology; D008297:Male; D009584:Nitrogen / Q000378:metabolism; D010289:Parenteral Nutrition, Total; D051381:Rats; D017208:Rats, Wistar
D000596:Amino Acids; D004151:Dipeptides; D005973:Glutamine; D009584:Nitrogen; C054122:alanylglutamine