title: Inhibitory effects of 2'-deoxy-5-styryluridine 5'-triphosphate analogs on retroviral reverse transcriptase and eukaryotic DNA polymerases.
abstract: Some sugar modified analogs of 2'-deoxy-E-5-styryluridine triphosphates were synthesized and examined for their inhibitory effects on eukaryotic DNA polymerases and HIV-1 reverse transcriptase. Among these compounds, 3'-azido-2',3'-dideoxy-E-5-styrylUTP (6) and 2',3'-dideoxy-E-5-styrylUTP (7) showed remarkable inhibitory effects on reverse transcriptase. The mode of action and the influence of the substituent at C-5 of 2',3'-dideoxyUTP analogs will be described.
authors.affiliation: Department of Biological Sciences, Nishi-Tokyo University, Yamanashi, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Yamaguchi
authors.forename: S
authors.initials: S
authors.lastname: Izuta
authors.forename: M
authors.initials: M
authors.lastname: Suzuki
authors.forename: S
authors.initials: S
authors.lastname: Yoshida
authors.forename: A
authors.initials: A
authors.lastname: Matsukage
authors.forename: M
authors.initials: M
authors.lastname: Saneyoshi
mesh_terms: D005057:Eukaryotic Cells / Q000201:enzymology; D054303:HIV Reverse Transcriptase; D019384:Nucleic Acid Synthesis Inhibitors; D018894:Reverse Transcriptase Inhibitors; D013343:Styrenes / Q000494:pharmacology*; D014544:Uridine Triphosphate / Q000031:analogs & derivatives* / Q000494:pharmacology
chemical_list: D019384:Nucleic Acid Synthesis Inhibitors; D018894:Reverse Transcriptase Inhibitors; D013343:Styrenes; D054303:HIV Reverse Transcriptase; D014544:Uridine Triphosphate