title: Epithelioid cell histiocytoma. A clinicopathologic and immunohistochemical study of eight cases.
abstract: BACKGROUND
  Epithelioid cell histiocytomas histologically resemble the intradermal form of Spitz nevus.
  
  
  OBJECTIVE
  We have studied eight patients with epithelioid cell histiocytoma.
  
  
  METHODS
  In addition to the routine stains, histologic sections were prepared by immunohistochemical techniques for S-100 protein, HMB-45, vimentin, alpha 1-antitrypsin, and common leukocyte antigen.
  
  
  RESULTS
  Epithelioid cell histiocytoma is characterized by proliferation of angulated epithelioid cells with abundant eosinophilic cytoplasm. Immunostaining for S-100 protein and HMB-45 were negative. The majority of cells had positive reactions to staining for vimentin and alpha 1-antitrypsin. Approximately 20% to 25% of cells also gave positive reactions to common leukocyte antigen.
  
  
  CONCLUSIONS
  Immunostainings are useful in the differential diagnosis of epithelioid cell histiocytoma from the intradermal form of Spitz nevus.
authors.affiliation: Pinkus Dermatopathology Laboratory, Monroe, Michigan.
authors.forename: A H
authors.initials: AH
authors.lastname: Mehregan
authors.forename: D R
authors.initials: DR
authors.lastname: Mehregan
authors.forename: A
authors.initials: A
authors.lastname: Broecker
mesh_terms: D000328:Adult; D000368:Aged; D001399:Azure Stains; D015622:Epithelioid Cells / Q000473:pathology; D005260:Female; D018219:Histiocytoma, Benign Fibrous / Q000473:pathology*; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008875:Middle Aged; D009506:Nevus / Q000473:pathology; D012878:Skin Neoplasms / Q000473:pathology*
chemical_list: D001399:Azure Stains