[Studies on transdermal delivery system of isosorbide dinitrate].
A transdermal delivery system of isosorbide dinitrate (ISDN-TDS) and an HPLC method for the measurement of ISDN were developed. The system is composed of backing, drug reservoir, control membrane, contact adhesive and protective layer. The influences of drug reservoir, solvent, control membrane, viscosity and penetration enhancer azone on the release of ISDN were investigated. The cumulative released amount of ISDN/time profile indicated that ISDN was permeated through excised skin in a zero-order kinetic in 48 h. The release of ISDN from ISDN-TDS can last 72 h at least. The mean permeation rate is 13.76 micrograms.h-1/cm2. Releasing ISDN from ISDN-TDS was more stable than that from Frandol tape-s whose release profile was found to follow a linear Q vs t1/2 relationship with a release flux of 114.39 micrograms.h-1/cm2.
Ji
A M
AM
Zhujiang Hospital, First Military Medical University, Guangzhon.
Jiang
X T
XT
Wang
X F
XF
Zou
H Q
HQ
D000279:Administration, Cutaneous; D000818:Animals; D016503:Drug Delivery Systems; D006168:Guinea Pigs; D066298:In Vitro Techniques; D007548:Isosorbide Dinitrate / Q000008:administration & dosage*; D012869:Skin Absorption
D007548:Isosorbide Dinitrate