title: Exclusion probabilities of red cell antigen systems for Chinese.
abstract: Little data are available in the literature for Chinese people, regarding genotype frequencies of red cell antigen systems. Furthermore, no recommendations for proper selection of red cell antigen systems for paternity testing have been established for a Chinese population. Consequently, calculating a paternity index is impossible. Blood typing of 336-1919 samples of Taiwanese Chinese was undertaken to determine various red blood cell antigens. Gene frequencies and probabilities of exclusion (PE) for the red cell antigen systems were then analyzed. The distributions of the red cell antigens were quite homogeneous. The incidence of D, s, k, Fya and Lub antigens was high, 99.6%, 99.7%, 100%, 99.8% and 99.4%, respectively. On the contrary, that for the K antigen was very low. The PE for the ABO, Rh, MNSs, Kell, Duffy, Kidd, P, and Lutheran systems was 0.1910, 0.1961, 0.2237, 0.0003, 0.0444, 0.1870, 0.0806, and 0, respectively. The cumulative PE (CPE) using ABO, Rh, MNSs, Kell, Duffy, Kidd, P and Lutheran systems was 0.6394, while CPE for ABO, Rh, MNSs, Duffy, Kidd, and P systems was 0.6394. Thus, it appears that the Kell and Lutheran systems are not suitable for paternity testing because of their low probability of exclusions. Duffy system may also be excluded for its low PE. The CPE for ABO, Rh, MNSs, Kidd and P systems was 0.6226.
authors.affiliation: Department of Clinical Pathology, Chang Gung Memorial Hospital, Taipei,Taiwan, Republic of China.
authors.forename: C F
authors.initials: CF
authors.lastname: Sun
authors.forename: K C
authors.initials: KC
authors.lastname: Tsao
authors.forename: C H
authors.initials: CH
authors.lastname: Teh
mesh_terms: D044466:Asian People / Q000235:genetics; D001789:Blood Group Antigens / Q000235:genetics*; D002681:China; D004912:Erythrocytes / Q000276:immunology*; D005787:Gene Frequency; D005838:Genotype; D006801:Humans; D008297:Male; D010334:Paternity; D011336:Probability; D013624:Taiwan
chemical_list: D001789:Blood Group Antigens