Immunohistochemical evidence for a crossed cholecystokinin corticostriatal pathway in the rat.
Using the indirect immunofluorescence technique, the effects of decortication and callosotomy on the pattern of cholecystokinin (CCK)-like immunoreactivity were studied in the striatum of the rat. Decortication plus callosotomy, but not decortication alone, caused a strong decrease in the immunoreactivity on the side ipsilateral to the lesion. An almost complete disappearance of CCK immunoreactive patches in the medial-dorsal aspects of the striatum was observed. These results indicate that part of the striatal CCK immunoreactive fibres are of cortical origin, to a considerable extent from the contralateral side.
Morino
P
P
Department of Histology and Neurobiology, Karolinska Institute, Stockholm, Sweden.
Herrera-Marschitz
M
M
Meana
J J
JJ
Ungerstedt
U
U
Hökfelt
T
T
D000818:Animals; D002421:Caudate Nucleus / Q000166:cytology / Q000502:physiology*; D002540:Cerebral Cortex / Q000166:cytology / Q000502:physiology*; D002766:Cholecystokinin / Q000032:analysis*; D003337:Corpus Callosum / Q000166:cytology / Q000502:physiology*; D005455:Fluorescent Antibody Technique; D007150:Immunohistochemistry; D007608:Kainic Acid / Q000008:administration & dosage; D008297:Male; D009412:Nerve Fibers / Q000648:ultrastructure; D051381:Rats; D017207:Rats, Sprague-Dawley; D013238:Stereotaxic Techniques
D002766:Cholecystokinin; D007608:Kainic Acid