Staphylococcal L-asparaginase: catabolic repression of synthesis.
The regulation mechanism of production of staphylococcal L-asparaginase was investigated. The role of cAMP in regulation of its synthesis was confirmed. Production of L-asparaginase from S. aureus NCTC 4135 was inhibited by all carbon sources, mono- and disaccharides added to the growth medium. The strongest inhibition was caused by saccharose and maltose, whereas weaker by galactose, lactose, mannitol and mannose. It was found that exogenous cAMP in the presence of carbon sources stimulated synthesis of the investigated enzyme.
Rózalska
M
M
Department of Pharmaceutical Microbiology, Medical University, Lódz, Poland.
Mikucki
J
J
D001215:Asparaginase / Q000096:biosynthesis*; D004187:Disaccharides / Q000494:pharmacology; D015964:Gene Expression Regulation, Bacterial / Q000187:drug effects; D019298:Glucose-6-Phosphate; D005958:Glucosephosphates / Q000494:pharmacology; D009005:Monosaccharides / Q000494:pharmacology; D013210:Staphylococcus / Q000201:enzymology*
D004187:Disaccharides; D005958:Glucosephosphates; D009005:Monosaccharides; D019298:Glucose-6-Phosphate; D001215:Asparaginase