Chemical synthesis, growth-promoting activity, and metabolism of all-trans retinyl beta-glucose in the rat.
Reaction of all-trans retinol with alpha-D-glucopyranosyl bromide tetrabenzoate in the presence of silver carbonate gave all-trans retinyl beta-glucose in good yield. Depending on the mode of administration, retinyl beta-glucose, which is soluble in water, showed 67-100% of the growth-promoting activity of retinyl acetate in vitamin A-deficient rats. In metabolic studies on vitamin A-deficient rats, retinyl beta-glucose was rapidly hydrolyzed to retinol. The possible therapeutic uses of retinyl glucose are discussed.
Barua
A B
AB
Department of Biochemistry & Biophysics, Iowa State University, Ames 50011.
Olson
J A
JA
D000818:Animals; D005960:Glucosides / Q000138:chemical synthesis* / Q000378:metabolism / Q000494:pharmacology; D006133:Growth Substances / Q000138:chemical synthesis* / Q000378:metabolism / Q000494:pharmacology; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley; D014801:Vitamin A / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000378:metabolism / Q000494:pharmacology; D014802:Vitamin A Deficiency / Q000188:drug therapy* / Q000378:metabolism
D005960:Glucosides; D006133:Growth Substances; D014801:Vitamin A; C079883:retinylglucose