title: Surfactant replacement therapy improves pulmonary mechanics in end-stage influenza A pneumonia in mice.
abstract: Surfactant replacement therapy may be a promising approach for treatment of respiratory failure caused by viral pneumonia. This study in mice demonstrates that during the development of lethal influenza A pneumonia, thorax-lung compliance (Ctl/kg) and lung volume at 5 cm H2O PEEP (V5/kg) significantly decrease (28 and 54%, respectively), whereas lung water content significantly increases (25%). Surfactant replacement therapy during the end stage of pneumonia significantly increases Ctl/kg (31%) and V5/kg (21%). Instillation of the vehicle for surfactant in control animals does not significantly affect Ctl/kg (5% decrease), but it significantly decreases V5/kg (25% decrease). Further, a new method for postmortem measurement of lung volumes in small laboratory animals based on Archimedes' principle is presented.
authors.affiliation: Department of Anesthesiology, Erasmus University, Rotterdam, The Netherlands.
authors.forename: G J
authors.initials: GJ
authors.lastname: Van Daal
authors.forename: J A
authors.initials: JA
authors.lastname: Bos
authors.forename: E P
authors.initials: EP
authors.lastname: Eijking
authors.forename: D
authors.initials: D
authors.lastname: Gommers
authors.forename: E
authors.initials: E
authors.lastname: Hannappel
authors.forename: B
authors.initials: B
authors.lastname: Lachmann
mesh_terms: D000818:Animals; D009980:Influenza A virus; D008176:Lung Volume Measurements / Q000662:veterinary; D008297:Male; D051379:Mice; D009976:Orthomyxoviridae Infections / Q000503:physiopathology / Q000628:therapy*; D011024:Pneumonia, Viral / Q000382:microbiology / Q000503:physiopathology / Q000628:therapy*; D011663:Pulmonary Surfactants / Q000627:therapeutic use*; D015656:Respiratory Mechanics / Q000502:physiology
chemical_list: D011663:Pulmonary Surfactants