title: Twice daily 4% Sodium Cromoglycate vs. 2% Sodium Cromoglycate used four times daily in seasonal (grass pollen) allergic conjunctivitis.
abstract: It is well established that 2% Sodium Cromoglycate is an effective treatment for a number of allergic eye diseases. It has been shown to be non-toxic. It can be used longterm and in serious allergic problems it is a useful adjunctive therapy to steroids. The main problem with Sodium Cromoglycate is that the recommended dosage is a four times daily application and patient non-compliance is common. One of the main objectives of any therapy is to reduce the frequency of dosage and the current study has been designed to investigate the efficacy of a 4% solution of Sodium Cromoglycate, used twice daily, versus a 2% solution used four times daily in seasonal allergic conjunctivitis. A multicentre study, therefore, was carried out to assess the efficacy of both drugs and to assess any possibility of side effects. In addition, a unit dose was used, thus eliminating preservatives and it was used specifically in seasonal allergic conjunctivitis in the pollen season. This study showed that 4% Sodium Cromoglycate used twice daily was at least as affective as 2% Sodium Cromoglycate used four times daily.
authors.affiliation: Royal Victoria Eye and Ear Hospital, Dublin, Ireland.
authors.forename: L M
authors.initials: LM
authors.lastname: Collum
authors.forename: S
authors.initials: S
authors.lastname: Fitzsimon
authors.forename: M
authors.initials: M
authors.lastname: Hillery
authors.forename: A
authors.initials: A
authors.lastname: Collum
authors.forename: W J
authors.initials: WJ
authors.lastname: Power
authors.forename: Z
authors.initials: Z
authors.lastname: Pelikan
authors.forename: J B
authors.initials: JB
authors.lastname: Jenson
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002648:Child; D003233:Conjunctivitis, Allergic / Q000188:drug therapy*; D004205:Cromolyn Sodium / Q000008:administration & dosage* / Q000627:therapeutic use; D004311:Double-Blind Method; D004334:Drug Administration Schedule; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D012621:Seasons
chemical_list: D004205:Cromolyn Sodium