title: [The neurotropic properties of new 4,4-di-substituted derivatives of 1-methylpiperidine].
abstract: Experiments on small laboratory animals were made to study local anesthetic, antinociceptive and antihypoxic properties of 6 new derivatives of 1-methylpiperidine. A substance coded phi AB-8 (1-methyl-4-vinylethynil-4-benzoyl hydroxypiperidine hydrochloride) was found to exert a pronounced local anesthetic and an antihypoxic actions.
authors.forename: N M
authors.initials: NM
authors.lastname: Kurbat
authors.forename: T A
authors.initials: TA
authors.lastname: Korshak
authors.forename: P B
authors.initials: PB
authors.lastname: Stankevich
authors.forename: V I
authors.initials: VI
authors.lastname: Kozlovskiĭ
mesh_terms: D000208:Acute Disease; D000779:Anesthetics, Local / Q000494:pharmacology* / Q000627:therapeutic use / Q000633:toxicity; D000818:Animals; D004353:Drug Evaluation, Preclinical; D004347:Drug Interactions; D006168:Guinea Pigs; D000860:Hypoxia / Q000188:drug therapy; D007928:Lethal Dose 50; D051379:Mice; D009043:Motor Activity / Q000187:drug effects; D009420:Nervous System / Q000187:drug effects*; D010880:Piperidines / Q000494:pharmacology* / Q000627:therapeutic use / Q000633:toxicity; D011898:Ranidae; D051381:Rats; D013329:Structure-Activity Relationship
chemical_list: D000779:Anesthetics, Local; D010880:Piperidines
vernacular_title: Neĭrotropnye svoĭstva novykh 4,4-di-zameshchennykh proizvodnykh 1-metilpiperidina.