[Pharmacokinetics of liensinine in rabbits].
A method for the determination of plasma concentration of liensinine with HPLC and pharmacokinetic study of liensinine in rabbits were reported. Assay linearity was shown over the range of 0.125-2.5 micrograms/ml serum with regression coefficient of 0.9997. The mean recoveries of liensinine in plasma (within-day and between-days) were all more than 99% of the dose and the coefficients of variation were less than 5%. After a single intravenous injection of liensinine 6mg/kg to rabbit. The pharmacokinetic characteristics were found to fit a two-compartment open model. Important parameters were: t1/2 alpha = 8.303 min t1/2 beta = 129.960min AUC = 132.67 micrograms.min/ml CL = 0.045 L/min Vc = 2.768 L/kg.
Hu
X
X
Hubei Medical College, Wuchang.
Zhang
X
X
Cai
H
H
Lou
S
S
Yin
W
W
D000818:Animals; D002851:Chromatography, High Pressure Liquid; D004365:Drugs, Chinese Herbal / Q000737:chemistry*; D005260:Female; D007546:Isoquinolines / Q000493:pharmacokinetics*; D008297:Male; D010636:Phenols / Q000493:pharmacokinetics*; D011817:Rabbits
D004365:Drugs, Chinese Herbal; D007546:Isoquinolines; D010636:Phenols; C080095:liensinine