[The effect of muscarinic receptor blockers on non-specific bronchial reactivity in patients with bronchial asthma].
The effect of two anticholinergic drugs, Ipratropium bromide, nonselective muscarinic receptor antagonist and Pirenzepine, a selective M1 receptor blocker on bronchospasm induced by metacholine and histamine was investigated. The studies were carried out in a group of 52 asthmatic patients. The provocation tests were made by the Ryan method using a De Vilbiss nebuliser connected to a Rosenthal-French dosimeter. It was shown that both drugs protect significantly metacholine induced bronchospasm, but Ipratropium was more effective than Pirenzepine, which suggest that blockade of the M1 receptors only is not sufficient for a complete limitation of bronchi response to metacholine challenge. After histamine provocation some limitation of bronchial reactivity by two investigated drugs was also observed, but not so marked as after metacholine provocation. No significant differences between the effects of Pirenzepine and Ipratropium on histamine induced bronchospasm were observed.
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Kliniki Alergologii AM, Białymstoku.
D000328:Adult; D001249:Asthma / Q000188:drug therapy*; D001985:Bronchial Provocation Tests; D001986:Bronchial Spasm / Q000175:diagnosis / Q000188:drug therapy; D002794:Choline / Q000031:analogs & derivatives; D005260:Female; D006632:Histamine; D006801:Humans; D009241:Ipratropium / Q000627:therapeutic use*; D008297:Male; D010890:Pirenzepine / Q000627:therapeutic use*
D010890:Pirenzepine; D006632:Histamine; D009241:Ipratropium; D002794:Choline
Wpływ zwiaków blokujacych receptory muskarynowe na nieswoista reaktywność oskrzeli u chorych na dychawice oskrzelowa.