title: Isolated IgA deficiency accompanied by autoimmune thyroid disease.
abstract: Selective immunoglobulin (Ig) A deficiency is reported to occur in 1 in 16,000 in Japan and has been reported to be complicated with various autoimmune diseases. A 49-year-old woman was diagnosed as having autoimmune thyroid disease. Her serum IgA, IgM and IgG were revealed to be 4.1, 154 and 1930 mg/dl, respectively. Severe skin eruption which occurred with 30 mg/day of methimazole (MMI) or 300 mg/day of propylthiouracil (PTU), was relieved by reducing MMI to 15 mg/day and administering anti-allergic drugs. Although the influence of IgA deficiency on autoimmunity and allergy still remains unclear, this is a report of IgA deficiency associated with autoimmune thyroid disease.
authors.affiliation: Department of Internal Medicine, Anjo Kosei Hospital, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Mano
authors.forename: A
authors.initials: A
authors.lastname: Kawakubo
authors.forename: M
authors.initials: M
authors.lastname: Yamamoto
mesh_terms: D001327:Autoimmune Diseases / Q000150:complications / Q000175:diagnosis* / Q000188:drug therapy / Q000601:surgery; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D017098:IgA Deficiency / Q000150:complications*; D007136:Immunoglobulins / Q000097:blood; D008713:Methimazole / Q000009:adverse effects / Q000627:therapeutic use; D008875:Middle Aged; D011441:Propylthiouracil / Q000009:adverse effects / Q000627:therapeutic use; D013961:Thyroid Gland / Q000473:pathology; D013963:Thyroid Hormones / Q000097:blood; D013971:Thyrotoxicosis / Q000150:complications / Q000175:diagnosis* / Q000188:drug therapy / Q000601:surgery
chemical_list: D007136:Immunoglobulins; D013963:Thyroid Hormones; D008713:Methimazole; D011441:Propylthiouracil