[Blood and urine prostaglandin E2 and prostaglandin F2 alpha in patients with chronic gastritis and peptic ulcer].
The blood and urine prostaglandin E2 (PGE2), Prostaglandin F2 alpha (PGF2 alpha) in 106 cases of chronic gastritis and peptic ulcer were investigated by RIA. Meanwhile, the relationship among PGE2, PGF2 alpha and the Syndromes of TCM were approached. The result showed: In comparing with the normal control, the blood and urine PGE2 of 106 cases were obviously higher (P < 0.01), but PGF2 alpha was not (P > 0.05). The urine PGE2 and PGF2 alpha of moderate gastritis were markedly higher than those of mild gastritis (P < 0.05), but there were no significant difference between blood PGE2, PGF2 alpha of moderate gastritis and those of mild gastritis (P > 0.05). The blood PGE2, PGE2/PGF2 alpha ratio of Dampness-Heat in Spleen-Stomach Syndrome and the blood PGE2/PGF2 alpha ratio of incoordination between Liver and Stomach Syndrome were higher than those of Spleen Stomach Deficiency Syndrome in all the cases (P < 0.05). Compared with the normal control, both the decreased amplitude of blood PGE2/urine PGE2 and increased amplitude of blood PGF2 alpha/urine PGF2 alpha ratio showed as following: Spleen-Stomach Deficiency Syndrome > incoordination between Liver and stomach Syndrome > Dampness-Heat in Spleen-Stomach Syndrome. This study suggested: (1) There was a close relation between PGE2 and chronic gastritis and peptic ulcer; (2) There was no correlation between blood PGE2, PGF2 alpha and urine PGE2, PGF2 alpha; (3) PG was possibly a useful objective parameter to the Syndrome Differentiation in TCM.
Zhang
S S
SS
Beijing Institute of TCM.
Jin
J S
JS
Zhao
R L
RL
D000328:Adult; D000368:Aged; D015237:Dinoprost / Q000378:metabolism*; D015232:Dinoprostone / Q000378:metabolism*; D005260:Female; D005756:Gastritis / Q000145:classification / Q000378:metabolism*; D006801:Humans; D008297:Male; D008516:Medicine, Chinese Traditional; D008875:Middle Aged; D010437:Peptic Ulcer / Q000145:classification / Q000378:metabolism*; D011863:Radioimmunoassay
D015237:Dinoprost; D015232:Dinoprostone