Cloning and mutational analysis of SRY.
A candidate for the male sex-determining gene has recently been isolated. This sex-determining gene (SRY) has been found to be mutated in some individuals with failed testis development, and, in mouse transgenesis, the SRY murine homologue (Sry) causes female-to-male sex reversal. The cloning of SRY should facilitate the characterisation of other genes in the testis-determining pathway and provide information on the mechanism of mammalian developmental decisions.
Hawkins
J R
JR
University Department of Genetics, Cambridge, UK.
D000818:Animals; D003001:Cloning, Molecular; D004252:DNA Mutational Analysis; D012734:Disorders of Sex Development / Q000235:genetics; D005260:Female; D006801:Humans; D008297:Male; D051379:Mice; D012732:Sex Determination Analysis; D012733:Sex Differentiation / Q000235:genetics*; D013737:Testis / Q000196:embryology; D014960:X Chromosome; D014998:Y Chromosome