[Detection of carriers of hemophilia B].
Thirty-two families with haemophilia B were divided into sub-groups based on assessment of fIX:Ag, fIX:C and the thromboplastin time with bovine thromboplastin. In confirmed carriers from these families after assessment of fIX:Ag and, fIX:C the normal range of individual sub-groups of confirmed carriers was assessed and compared with values of fiX:Ag and fiX:C of the control group. It will be possible to use these groups after their extension to assess probable carriers in sub-groups CRM+ and CRM-. In the sub-group CRMR the only criterium of transmission is a reduced fIX:C level. A prolonged TP with bovine thromboplastin in families with BM haemophilia cannot be used to assess carriers.
Hrachovinová
I
I
Ustav hematologie a krevní transfúze, Praha.
Vorlová
Z
Z
D000328:Adult; D005260:Female; D006580:Genetic Carrier Screening / Q000379:methods; D002836:Hemophilia B / Q000175:diagnosis*; D006801:Humans; D008875:Middle Aged
Moznosti stanovení prenasecství hemofilie B.