[Electrical stimulation in the treatment of osteoporosis in sciatic denervated rat tibia].
Osteoporosis in the sciatic-denervated rat tibia was reversed with a capacitively coupled electrical field. In the reversal of a previously established osteoporosis, a statistically significant enhancement of wet weight, dry weight, ashed weight, ultimate strength, cortical area, cortical thickness and a concomitant decrease in cortical porosity occurred in the stimulated, denervated tibiae of the experimental animals compared with the nonstimulated, denervated tibiae of the control animals. A 60 Hz symmetrical sinewave signal was effective in reversing osteoporosis at 10 V peak to peak. Reversal of a well-established osteoporosis in laboratory animals has not been reported previously.
Li
M
M
Changhai Hospital, Second Military Medical University, Shanghai.
D000818:Animals; D003714:Denervation; D004599:Electric Stimulation Therapy / Q000379:methods*; D004574:Electromagnetic Fields; D008297:Male; D010024:Osteoporosis / Q000209:etiology / Q000628:therapy*; D051381:Rats; D017208:Rats, Wistar; D012584:Sciatic Nerve / Q000502:physiology; D013977:Tibia / Q000294:innervation*