The use of near infrared spectroscopy in the quality control laboratory of the pharmaceutical industry.
The suitability of NIR spectroscopy as an alternative to several compendial test methods is discussed. Using ampicillin trihydrate as an example it is demonstrated that eight quality criteria are controlled by recording the NIR spectrum of a batch sample and calculating its Conformity Index.
Plugge
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Gist-brocades b.v., Quality Assurance Department, Industrial Pharmaceutical Products Division, Delft, The Netherlands.
van der Vlies
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C
D000667:Ampicillin / Q000032:analysis*; D002626:Chemistry, Pharmaceutical; D008997:Monobactams / Q000032:analysis*; D011786:Quality Control; D015203:Reproducibility of Results; D013055:Spectrophotometry, Infrared
D008997:Monobactams; D000667:Ampicillin