The immune response of sheep to subclinical chronic exposure to the herbicide Bentazon TP.
A study of the effect of the Czechoslovakian herbicide BENTAZON TP on cells of the sheep immune system was carried out over a 3-mo period. A temporary decline in the number of T-lymphocytes in the peripheral blood was seen after 6 w of daily feeding of the herbicide. Dose-dependent statistically significant changes in the leucocyte migration index (p < 0.05) were seen at daily doses of 1/10 the LD50 (195 mg/kg body weight) and 1/20 the LD50 (97.5 mg/kg body weight) the 8th and 10th w of feeding, respectively. Significant changes of phagocytic activity and in the phagocytic index were not observed.
Mikula
I
I
Department of Microbiology and Immunology, University of Veterinary Medicine, Kosice, Czechoslovakia.
Pistl
J
J
Kacmar
P
P
D000818:Animals; D001581:Benzothiadiazines / Q000633:toxicity*; D006540:Herbicides / Q000633:toxicity*; D007107:Immune System / Q000187:drug effects*; D007928:Lethal Dose 50; D010587:Phagocytosis / Q000187:drug effects; D012756:Sheep / Q000276:immunology*; D013601:T-Lymphocytes / Q000187:drug effects
D001581:Benzothiadiazines; D006540:Herbicides; C002003:bentazone