[The effect of sodium salicylate and phenobarbital on the anti-arrhythmia properties of novocainamide and acetylnovocainamide].
CaCl2 and aconitic models of arrhythmias were reproduced in experiments with rats. Sodium salicylate was found to decrease the preventive effect of ecetylnovocainamidum and increased the effect of novocainamidum on ECG changes. Sodium salicylate diminished the preventive effect of acetyl-novocainamidum by elevating myocardial Na+ concentrations, favoured the decrease in myocardial K+ levels, eliminated the preventive effects of novocainamide and acetylnovocainamide by altering myocardial energy metabolism in CaCl2-induced arrhythmia and improved the preventive effect of acetyl-novocainamide on these parameters in aconitic arrhythmia.
Beregovaia
E G
EG
Gorchakova
N A
NA
Dunaev
V V
VV
Chekman
I S
IS
D000120:Acecainide / Q000627:therapeutic use*; D000157:Aconitine; D000818:Animals; D001145:Arrhythmias, Cardiac / Q000097:blood / Q000139:chemically induced / Q000188:drug therapy / Q000503:physiopathology; D002122:Calcium Chloride; D004353:Drug Evaluation, Preclinical; D004347:Drug Interactions; D004359:Drug Therapy, Combination; D004562:Electrocardiography / Q000187:drug effects; D005260:Female; D008297:Male; D010634:Phenobarbital / Q000627:therapeutic use*; D011342:Procainamide / Q000627:therapeutic use*; D051381:Rats; D017208:Rats, Wistar; D012980:Sodium Salicylate / Q000627:therapeutic use*
D000120:Acecainide; D011342:Procainamide; D002122:Calcium Chloride; D012980:Sodium Salicylate; D000157:Aconitine; D010634:Phenobarbital
Vliianie natriia salitsilata i fenobarbitala na antiaritmicheskie svoĭstva novokainamida i atsetilnovokainamida.