Utility of beige mouse in leprosy research.
Dissemination of M. leprae to visceral organs is seen by four months onwards only in beige (C57BL/6/bgj) but not BALB/c mice following intravenous or intraperitoneal infections. Inoculation of the beige mouse derived M. leprae showed all the characteristics of M. leprae, including growth pattern in the foot-pads of BALB/c mice. M. leprae inoculated into foot-pads of beige mice multiplied faster than those in the foot-pads of BALB/c mice. The possibility of using beige mouse in chemotherapeutic studies in leprosy is discussed.
Gangadharam
P R
PR
Division of Infectious Diseases, University of Illinois School of Medicine, Chicago 60612.
Dhople
A M
AM
D000818:Animals; D004195:Disease Models, Animal; D005260:Female; D007918:Leprosy / Q000382:microbiology*; D008099:Liver / Q000382:microbiology; D051379:Mice; D008807:Mice, Inbred BALB C; D008810:Mice, Inbred C57BL / Q000382:microbiology*; D009166:Mycobacterium leprae / Q000254:growth & development*; D013154:Spleen / Q000382:microbiology