title: Evolution from semi-tRNA to tRNAs, rRNAs and an early peptide-synthesizing RNA molecule.
abstract: tRNA was found to have emerged by tandem duplication of a ca. 37-base RNA ("semi-tRNA"). The most ancestral anticodon was "(5')CCA(3')". The peptidyltransferase (PT) region of 23S rRNA was concluded to be a 5S rRNA homologue. Important evidences were obtained for elucidating that the RNA transcript from the Bacillus subtilis (BSU) trrnD operon is a relic of an early peptide-synthesizing ribozyme.
authors.affiliation: Department of Biology, Faculty of Science, Niigata University, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Ohnishi
mesh_terms: D000595:Amino Acid Sequence; D001412:Bacillus subtilis / Q000235:genetics; D001483:Base Sequence; D005075:Biological Evolution; D004926:Escherichia coli / Q000235:genetics; D008969:Molecular Sequence Data; D010455:Peptides / Q000235:genetics*; D012329:RNA, Bacterial / Q000235:genetics / Q000378:metabolism; D016337:RNA, Catalytic / Q000378:metabolism; D012338:RNA, Ribosomal, 23S / Q000235:genetics* / Q000378:metabolism; D012341:RNA, Ribosomal, 5S / Q000235:genetics / Q000378:metabolism; D012343:RNA, Transfer / Q000235:genetics* / Q000378:metabolism; D016415:Sequence Alignment
chemical_list: D010455:Peptides; D012329:RNA, Bacterial; D016337:RNA, Catalytic; D012338:RNA, Ribosomal, 23S; D012341:RNA, Ribosomal, 5S; D012343:RNA, Transfer