[The changes in plasma renin angiotensin and arginine vasopressin in pulmonary hypertension rats].
The plasma renin activity (RA), the concentration and the ratio of angiotensin (AI) conversion into angiotensin II (AII), and arginine vasopressin (AVP) level were observed in Wistar rats with pulmonary hypertension (PH) induced by extracardiac left-to-right shunting (LRS), hypobaric hypoxia (HH) and shunting plus HH (SHH). In comparison with normal control rats, RA in LRS and SHH rats showed an increasing trend, although no statistical significance appeared (P > 0.05). No change occurred in HH rats. The concentration and ratio of AI conversion into AII were significantly increased in LRS rats (P < 0.05), but decreased in HH and SHH rats (more markedly in HH rats). AVP increased significantly in LRS rats, and also showed an increasing trend in HH and SHH, but no significance was found (P > 0.05). The action of humoral factors in PH formation was discussed.
Guo
J
J
Cardiovascular Institute, Beijing.
D000803:Angiotensin I / Q000097:blood; D000804:Angiotensin II / Q000097:blood; D000818:Animals; D001127:Arginine Vasopressin / Q000097:blood; D006976:Hypertension, Pulmonary / Q000097:blood* / Q000209:etiology; D000860:Hypoxia / Q000150:complications; D051381:Rats; D017208:Rats, Wistar; D012083:Renin / Q000097:blood; D012084:Renin-Angiotensin System / Q000502:physiology*
D000804:Angiotensin II; D001127:Arginine Vasopressin; D000803:Angiotensin I; D012083:Renin