title: [The antimicrobial cationic proteins of the neutrophilic granulocytes in experimental Q rickettsiosis].
abstract: Blood of 56 guinea pigs with experimental Q rickettsiosis was studied cytochemically (lysosomal cationic test) to measure the level of cationic proteins in neutrophil granulocytes. Development of Q rickettsiosis resulted in a decrease in the killing ability of neutrophils, depending on infection dose introduced. However, by day 7 of the disease, the level of cationic proteins in blood neutrophil granulocytes returned to the initial range. Similar situation was noted after subcutaneous injection of Coxiella burnetti corpuscular antigen. Subcutaneous infection with the living culture stimulus induced the wave-like decrease of the cationic proteins content. Infection of pre-immunized animals led to smaller decrease in the cationic proteins levels and to their more rapid recovery. Aspects of antimicrobial activity of neutrophil granulocyte cationic proteins in experimental Q rickettsiosis is discussed.
authors.forename: V A
authors.initials: VA
authors.lastname: Kuzina
authors.forename: N K
authors.initials: NK
authors.lastname: Tokarevich
authors.forename: Iu A
authors.initials: IuA
authors.lastname: Mazing
mesh_terms: D000818:Animals; D000942:Antigens, Bacterial / Q000276:immunology; D001798:Blood Proteins / Q000276:immunology* / Q000378:metabolism; D002412:Cations; D016997:Coxiella burnetii / Q000276:immunology; D006168:Guinea Pigs; D006651:Histocytochemistry; D007114:Immunization / Q000379:methods; D008247:Lysosomes / Q000276:immunology / Q000378:metabolism; D008297:Male; D009504:Neutrophils / Q000276:immunology* / Q000378:metabolism; D011778:Q Fever / Q000097:blood / Q000209:etiology / Q000276:immunology*; D012283:Rickettsia prowazekii / Q000276:immunology; D013997:Time Factors
chemical_list: D000942:Antigens, Bacterial; D001798:Blood Proteins; D002412:Cations
vernacular_title: Antimikrobnye kationnye belki neĭtrofil'nykh granulotsitov pri éksperimental'nom Ku-rikketsioze.