Tumor radiotherapy monitoring with radioscintigraphy tracers: a comparative study with multiple-tracer technique.
A comparative multiple-tracer study was performed to assess the tracer feasibility of monitoring tumor radiotherapy. Metabolic tracers for glucose, amino acid, nucleic acid metabolism: F-18-FDG, C-14-Met, H-3-Thd, and F-18-FdUrd and conventional Ga-67 were compared in the same AH109A radiotherapy model using a new quadruple-tracer technique. F-18-FDG showed a large uptake change and a steady response to radiotherapy which is similar to Ga-67. F-18-FdUrd showed a rapid decrease, but the range of change in uptake was narrow. H-3-Thd and C-14-Met showed a rapid response to irradiation and a high sensitivity for monitoring radiotherapy, suggesting that if labeled with C-11, they may be feasible for PET study.
Kubota
K
K
Department of Radiology and Nuclear Medicine, Tohoku University, Sendai, Japan.
Ishiwata
K
K
Yamada
S
S
Kubota
R
R
Tada
M
M
Sato
T
T
Ido
T
T
D000818:Animals; D002250:Carbon Radioisotopes; D005462:Fluorine Radioisotopes; D008297:Male; D009374:Neoplasms, Experimental / Q000000981:diagnostic imaging / Q000532:radiotherapy*; D011849:Radioactive Tracers; D011877:Radionuclide Imaging; D051381:Rats; D011919:Rats, Inbred Strains; D014316:Tritium
D002250:Carbon Radioisotopes; D005462:Fluorine Radioisotopes; D011849:Radioactive Tracers; D014316:Tritium