Potential induction of osteogenesis by systemic administration of bovine bone proteins.
This study shows, apparently for the first time, that the administration of bone derived proteins (putative bone growth factors) obtained from bovine demineralized maxillaries has a direct effect on osteogenesis, affecting significantly some markers of bone formation such as lactate dehydrogenase activity and serum osteocalcin. Also, collagen deposition and bone protein turnover were markedly increased by the treatment, which may have important biological and clinical applications.
Marquínez
M
M
Departamento de Fisiología y Nutrición, Universidad de Navarra, Pamplona, Spain.
Elorriaga
M
M
Martínez
J A
JA
Larralde
J
J
D000818:Animals; D001857:Bone Matrix / Q000737:chemistry*; D002417:Cattle; D006133:Growth Substances / Q000302:isolation & purification / Q000494:pharmacology*; D008099:Liver / Q000187:drug effects; D009132:Muscles / Q000187:drug effects; D015675:Osteocalcin / Q000097:blood; D010012:Osteogenesis / Q000187:drug effects*; D014176:Protein Biosynthesis; D011506:Proteins / Q000302:isolation & purification / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D014020:Tissue Extracts / Q000494:pharmacology
D006133:Growth Substances; D011506:Proteins; D014020:Tissue Extracts; D015675:Osteocalcin