[Antibody formation to morphine and neuromediators in morphinized rats].
The paper demonstrates induction of antibodies to morphine and neurotransmitters (dopamine, norepinephrine, serotonin) in rats treated with intraperitoneal injections of morphine hydrochloride during 2 and 4 weeks in increasing doses. A contribution of such antibodies to the mechanisms of morphine tolerance and formation of physical dependence is considered.
Tronnikov
S I
SI
Gamaleia
N B
NB
Veretinskaia
A G
AG
Borisova
E V
EV
Sudakov
S K
SK
Anokhina
I P
IP
D000818:Animals; D000906:Antibodies / Q000097:blood; D000917:Antibody Formation / Q000187:drug effects; D015306:Biogenic Monoamines / Q000097:blood / Q000276:immunology*; D002908:Chronic Disease; D008297:Male; D009020:Morphine / Q000008:administration & dosage / Q000276:immunology*; D009021:Morphine Dependence / Q000097:blood / Q000209:etiology / Q000276:immunology*; D051381:Rats; D017208:Rats, Wistar; D013997:Time Factors
D000906:Antibodies; D015306:Biogenic Monoamines; D009020:Morphine
Obrazovanie antitel k morfinu i neĭromediatoram u morfinizizrovannykh krys.