title: An assessment of sputum induction as an aid to diagnosis of respiratory infections in the immunocompromised child.
abstract: Sputum induction using nebulised hypertonic saline was performed in two groups of immunocompromised children, one group with symptoms of respiratory infection and one group without. The asymptomatic group were bone marrow transplant (BMT) recipients, all seropositive for cytomegalovirus infection (CMV). Organisms were identified in three of 14 induced sputum specimens obtained from the symptomatic group (CMV N = 1, Haemophilus influenzae N = 2), but in none of 12 specimens from the asymptomatic group. Adverse effects encountered were minor. Four symptomatic patients with negative induced sputum samples underwent bronchoalveolar lavage, and no further organisms were identified. Sputum induction can be a useful adjunct to the diagnosis of respiratory pathogens in this group of patients.
authors.affiliation: Bone Marrow Transplant Unit, Bristol Royal Hospital for Sick Children, U.K.
authors.forename: A B
authors.initials: AB
authors.lastname: Foot
authors.forename: E O
authors.initials: EO
authors.lastname: Caul
authors.forename: A P
authors.initials: AP
authors.lastname: Roome
authors.forename: A
authors.initials: A
authors.lastname: Oakhill
authors.forename: J R
authors.initials: JR
authors.lastname: Catterall
mesh_terms: D000293:Adolescent; D000336:Aerosols; D001992:Bronchoalveolar Lavage Fluid / Q000382:microbiology; D002648:Child; D002675:Child, Preschool; D003587:Cytomegalovirus / Q000302:isolation & purification; D003586:Cytomegalovirus Infections / Q000175:diagnosis*; D006192:Haemophilus Infections / Q000175:diagnosis*; D006193:Haemophilus influenzae / Q000302:isolation & purification; D006801:Humans; D016867:Immunocompromised Host; D011446:Prospective Studies; D012141:Respiratory Tract Infections / Q000175:diagnosis*; D012462:Saline Solution, Hypertonic / Q000494:pharmacology; D013183:Sputum / Q000378:metabolism / Q000382:microbiology*
chemical_list: D000336:Aerosols; D012462:Saline Solution, Hypertonic