title: Central interaction between endothelin and brain natriuretic peptide on vasopressin secretion.
abstract: OBJECTIVE
  To examine the interaction between i.c.v. administration of endothelin and brain natriuretic peptide (BNP) on vasopressin (AVP) secretion in unanesthetized, freely moving rats.
  
  
  METHODS
  I.c.v. cannulation and femoral artery catheterization were performed 7-8 days and 2 days before the experiment, respectively. Endothelin and BNP were injected into the third ventricle through the guide cannula. One millilitre of blood was collected for AVP measurement 30 min before and 10 min after i.c.v. injection.
  
  
  RESULTS
  Central administration of endothelin (20 or 40 pmol/2 microliters) dose-dependently evoked the elevation of plasma AVP levels. Preinjection of BNP (0.2 or 1 nmol/3 microliters, i.c.v.) dose-dependently attenuated central endothelin (40 pmol/2 microliters)-induced plasma AVP secretion.
  
  
  CONCLUSIONS
  We have already reported that BNP attenuated central endothelin-induced pressor response and plasma catecholamine secretion. Taken together, the results indicate that BNP attenuated central endothelin-induced pressor response, at least partially, by suppressing sympathetic nervous system activation and plasma AVP secretion.
authors.affiliation: Third Department of Internal Medicine, Okayama University Medical School, Japan.
authors.forename: S
authors.initials: S
authors.lastname: Makino
authors.forename: K
authors.initials: K
authors.lastname: Hashimoto
authors.forename: R
authors.initials: R
authors.lastname: Hirasawa
authors.forename: T
authors.initials: T
authors.lastname: Hattori
authors.forename: Z
authors.initials: Z
authors.lastname: Ota
mesh_terms: D000818:Animals; D001127:Arginine Vasopressin / Q000097:blood / Q000378:metabolism*; D001794:Blood Pressure / Q000187:drug effects / Q000502:physiology; D016232:Endothelins / Q000502:physiology*; D008297:Male; D020097:Natriuretic Peptide, Brain; D009419:Nerve Tissue Proteins / Q000502:physiology*; D010904:Pituitary Gland, Posterior / Q000502:physiology; D051381:Rats; D011919:Rats, Inbred Strains
chemical_list: D016232:Endothelins; D009419:Nerve Tissue Proteins; D001127:Arginine Vasopressin; D020097:Natriuretic Peptide, Brain