The chemotherapy of rodent malaria. XLVII. Studies on pyronaridine and other Mannich base antimalarials.
The activities of Mannich base antimalarials, including pyronaridine, have been explored against drug-sensitive (Plasmodium berghei N) and chloroquine-resistant (Plasmodium yoelii NS) rodent malaria parasites in vivo. Lines of these parasites have been developed with resistance to pyronaridine, amodiaquine, or WR 228,258. The responses and patterns of cross-resistance of these lines to Mannich bases and other blood schizontocides are inconsistent. It is concluded that some Mannich bases may prove still to be of value inthe treatment of chloroquine-resistant Plasmodium falciparum infection.
Peters
W
W
Department of Medical Parasitology, London School of Hygiene and Tropical Medicine, St. Albans, U.K.
Robinson
B L
BL
D000634:Aminoquinolines / Q000627:therapeutic use; D000655:Amodiaquine / Q000627:therapeutic use; D000818:Animals; D000962:Antimalarials / Q000627:therapeutic use*; D004351:Drug Resistance; D008288:Malaria / Q000188:drug therapy* / Q000469:parasitology; D008352:Mannich Bases / Q000627:therapeutic use; D051379:Mice; D009287:Naphthyridines / Q000627:therapeutic use*; D010962:Plasmodium berghei / Q000187:drug effects; D010967:Plasmodium yoelii / Q000187:drug effects
D000634:Aminoquinolines; D000962:Antimalarials; D008352:Mannich Bases; D009287:Naphthyridines; D000655:Amodiaquine; C044651:tebuquine; C027871:pyronaridine