title: [Stereotaxic laser interstitial thermotherapy. A new alternative in the therapeutic management of some brain tumors].
abstract: Laser Interstitial Thermo Therapy (ITT) is a new procedure which has been performed only a few times in our department as well as in foreign services. The aim of an ITT is to increase the temperature of a tumoral target which has been perfectly determined stereotactically. In the center of the target, i-e at the extremity of the laser fibre, temperature reaches 80 degrees 90 degrees C and creates a coagulation necrosis. At the periphery of the target, temperature must be 41 degrees-43 degrees C so as to create a selective lesion of the pathological tissue due to proteinic and enzymatic denaturation. The authors present their experience based on 8 patients who underwent an ITT between June 1990 and October 1991. A stereotactic determination of the tumor is first performed; then two routes are determined for the laser-fibre (Nd-YAG 1.06 microns, fiber diameter: 400 mu) and for the thermic electrode. The ITT itself is performed a few days later (P = 3-5w, time: 800-1200 seconds). Laser heat effects are monitored with MRI controls (H5, H24, D8 then monthly). The authors insist on the importance of a long follow-up so as to be sure of the complete inocuity of such a treatment. It is the only way to broaden and develop laser-ITT procedures as therapeutic alternatives for certain deep-seated intracerebral tumors.
authors.affiliation: Centre Hospitalier Sainte-Anne, Service de neurochirurgie, Paris.
authors.forename: F X
authors.initials: FX
authors.lastname: Roux
authors.forename: L
authors.initials: L
authors.lastname: Merienne
authors.forename: C
authors.initials: C
authors.lastname: Fallet-Bianco
authors.forename: F
authors.initials: F
authors.lastname: Beuvon
authors.forename: B
authors.initials: B
authors.lastname: Devaux
authors.forename: B
authors.initials: B
authors.lastname: Leriche
authors.forename: C
authors.initials: C
authors.lastname: Cioloca
mesh_terms: D001932:Brain Neoplasms / Q000628:therapy*; D005260:Female; D005500:Follow-Up Studies; D005910:Glioma / Q000628:therapy; D006801:Humans; D006979:Hyperthermia, Induced / Q000379:methods*; D007834:Lasers; D008297:Male; D010911:Pituitary Neoplasms / Q000628:therapy; D013238:Stereotaxic Techniques
vernacular_title: La thermothérapie interstitielle laser stéréotaxique. Une nouvelle alternative dans la prise en charge thérapeutique de certaines tumeurs cérébrales.