[The anti-HIV activity of beta-glycyrrhizic acid].
The anti-HIV activity of beta-glycyrrhizic acid (GA) and various derivatives was studied using various strains of HIV-1 and HIV-2 in primary infected lymphoblastoid cells MT-4 and monocyte cell line U-973 chronically infected with HIV-1 and containing provirus (GKV 4005). Beta-glycyrrhizic acid and its derivatives were shown to effectively inhibit HIV-1 reproduction in MT-4 cells. The antiviral effect of beta-GA sodium salt exceeded that of AZT in cells GKV 4005. The selective indices for some GA salts were evaluated, namely: 53 for 1NH4 salt of GA, 6.7 for 1K-2Li salt of GA; 4.45 for GA. The mechanism of GA action is discussed.
Pliasunova
O A
OA
Egoricheva
I N
IN
Fediuk
N V
NV
Pokrovskiĭ
A G
AG
Baltina
L A
LA
Murinov
Iu I
IuI
Tolstikov
G A
GA
D000998:Antiviral Agents / Q000494:pharmacology*; D001312:Aurintricarboxylic Acid / Q000494:pharmacology; D003864:Depression, Chemical; D006034:Glycyrrhetinic Acid / Q000031:analogs & derivatives* / Q000494:pharmacology*; D019695:Glycyrrhizic Acid; D015497:HIV-1 / Q000187:drug effects* / Q000201:enzymology / Q000502:physiology; D015498:HIV-2 / Q000187:drug effects* / Q000201:enzymology / Q000502:physiology; D006801:Humans; D012996:Solutions; D013997:Time Factors; D014764:Viral Proteins / Q000032:analysis / Q000187:drug effects; D014776:Virus Cultivation; D014779:Virus Replication / Q000187:drug effects; D015215:Zidovudine / Q000494:pharmacology
D000998:Antiviral Agents; D012996:Solutions; D014764:Viral Proteins; D001312:Aurintricarboxylic Acid; D015215:Zidovudine; D019695:Glycyrrhizic Acid; D006034:Glycyrrhetinic Acid
Izuchenie anti-VICh-aktivnosti beta-glitsirrizinovoĭ kisloty.