title: [Water-salt metabolism and its hormonal regulation studied in the 2nd joint Soviet-French space flight].
abstract: During a 25-day space mission of French cosmonaut on board Mir station, the joint Soviet-French Czecho-Slovak experiment "Minilab" has been conducted in order to evaluate a fluid-electrolyte metabolism status and its hormonal control at different flight stages and early postflight. In cosmonaut venous blood was drawn twice, and 24-hour urine samples were collected on mission Days 5 and 19. With the aid of Plasma-02 equipment the blood plasma and urinary samples were treated, frozen and maintained aboard the station. Postflight, frozen samples were delivered to the laboratory for further analyses. In-flight, urinary excretion of fluid and sodium decreased by 25-35%. On mission Day 9, the blood plasma levels of vasopressin increased by 450% and on Day 20 by 700% as opposed to the baseline levels, blood aldosterone content was also elevated with an increased renal excretion of both hormones. Blood plasma renin activity elevated two-fold, and atrio-natriuretic factor (ANF) content practically did not differ from a baseline value. In-flight circulating plasma volume (CPV) decreased by 20%. Postflight, there occurred the body hypohydration and activation of the hormonal systems providing a retention of body fluids and electrolytes to restore an adequate CPV and fluid-electrolyte homeostatic as a whole.
authors.forename: A I
authors.initials: AI
authors.lastname: Grigor'ev
authors.forename: V B
authors.initials: VB
authors.lastname: Noskov
authors.forename: V V
authors.initials: VV
authors.lastname: Poliakov
authors.forename: Iu V
authors.initials: IuV
authors.lastname: Sukhanov
authors.forename: C
authors.initials: C
authors.lastname: Gharib
authors.forename: G
authors.initials: G
authors.lastname: Gaugueline
authors.forename: C
authors.initials: C
authors.lastname: Helen
authors.forename: R
authors.initials: R
authors.lastname: Kvĕtnanský
authors.forename: L
authors.initials: L
authors.lastname: Macho
mesh_terms: D000222:Adaptation, Physiological; D003604:Czechoslovakia; D004231:Diuresis / Q000502:physiology; D005602:France; D006728:Hormones / Q000502:physiology*; D006801:Humans; D013026:Space Flight; D013997:Time Factors; D014586:USSR; D014882:Water-Electrolyte Balance / Q000502:physiology*; D014893:Weightlessness
chemical_list: D006728:Hormones
vernacular_title: Issledovanie vodno-solevogo obmena i ego gormonal'noĭ reguliatsii vo vtorom sovmestnom sovetsko-frantsuzskom kosmicheskom polete.