The formation and enzymatic repair of DNA modifications caused by the haloethylnitrosoureas and related compounds.
The haloethylnitrosoureas are both useful antitumor agents and known carcinogens. These biological activities are believed to be associated with DNA modification, and some biologically significant lesions have been identified in DNA exposed to these agents. At the same time, DNA repair is a cause of resistance to treatment by these agents, and may also serve as protection against their carcinogenic effects.
Ludlum
D B
DB
Department of Pharmacology, University of Massachusetts, Worcester 01655.
Habraken
Y
Y
Carter
C A
CA
Matijasevic
Z
Z
D000818:Animals; D002417:Cattle; D004247:DNA / Q000187:drug effects* / Q000235:genetics; D004260:DNA Repair; D005038:Ethylnitrosourea / Q000031:analogs & derivatives / Q000633:toxicity*; D006219:Halogens / Q000737:chemistry / Q000633:toxicity*
D006219:Halogens; D004247:DNA; D005038:Ethylnitrosourea