[The effect of phytin, benzonal and their combination administered prophylactically on the pharmacodynamics of drugs metabolized in the liver in hypokinesia].
Hexenal, meprobamate, amidopyrine and ethylmorphine produced a significantly marked effect in animals under hypokinesia as compared with normal rats. When phytin, benzonal and their combination were used for preventive purposes, impaired pharmacodynamics of the tested drugs metabolizing in the liver disappeared. The investigations demonstrated that the preventive use of phytin in combination with benzonal is the most optimal in correcting the impairments of drug pharmacodynamics in hypokinesia.
Khakimov
Z Z
ZZ
Mavlianov
B R
BR
Rakhmanov
A Kh
AKh
Mavlianov
I R
IR
D000632:Aminopyrine / Q000493:pharmacokinetics / Q000494:pharmacology; D000818:Animals; D001463:Barbiturates / Q000008:administration & dosage / Q000494:pharmacology*; D001711:Biotransformation / Q000187:drug effects; D004347:Drug Interactions; D005036:Ethylmorphine / Q000493:pharmacokinetics / Q000494:pharmacology; D006591:Hexobarbital / Q000493:pharmacokinetics / Q000494:pharmacology; D007103:Immobilization / Q000502:physiology*; D008099:Liver / Q000187:drug effects* / Q000378:metabolism; D008297:Male; D008620:Meprobamate / Q000493:pharmacokinetics / Q000494:pharmacology; D010833:Phytic Acid / Q000008:administration & dosage / Q000494:pharmacology*; D051381:Rats; D013997:Time Factors
D001463:Barbiturates; D000632:Aminopyrine; D010833:Phytic Acid; D008620:Meprobamate; D006591:Hexobarbital; D005036:Ethylmorphine; C002915:benzobarbital
Vliianie fitina, benzonala i ikh kombinatsii pri profilakticheskom vvedenii na farmakodinamiku lekarstvennykh veshchestv, metaboliziruiushchikhsia v pecheni pri gipokinezii.