Principles of risk assessment.
This review discusses the basic principles of risk assessment as used in general toxicology and in monitoring side-effects of therapeutic treatments. It also outlines how these principles may apply to assessment of biological reactions to dental restorative materials. Mercury exposure from amalgam fillings is used as an example. The calculations performed are intended only as illustrations, and many other factors must be taken into account. Thus, the calculations are not intended as the last word in risk assessment of amalgam fillings.
Clarkson
T W
TW
School of Medicine and Dentistry, University of Rochester, NY 14642.
D001822:Body Burden; D003723:Dental Amalgam / Q000009:adverse effects*; D004305:Dose-Response Relationship, Drug; D006801:Humans; D016013:Likelihood Functions; D008452:Maximum Allowable Concentration; D008628:Mercury / Q000009:adverse effects / Q000652:urine; D016011:Normal Distribution; D016273:Occupational Exposure / Q000706:statistics & numerical data*; D012307:Risk Factors
D003723:Dental Amalgam; D008628:Mercury