[Free radical processes in the pathogenesis of alloxan diabetes].
Presents the results of studies of carbohydrate and peroxide metabolism, of antioxidant content in rats with alloxan diabetes under various levels of alimentary antioxidant consumption. Alloxan administration was found to result in biochemical and morphologic shifts characteristic of diabetes mellitus. The development of these changes runs against the background of enhanced free-radical processes. Simulation of alloxan diabetes in deficiency of alimentary antioxidants is conducive to the development of alloxan diabetes. The authors discuss the contribution of free-radical processes to the pathogenesis of alloxan diabetes and come to a conclusion on the usefulness of including antioxidant drugs in to a complex of therapeutic measures in this condition.
Bobyrev
V N
VN
Pocherniaeva
V F
VF
Dumenko
I L
IL
Bobyreva
L N
LN
D000818:Animals; D000975:Antioxidants / Q000494:pharmacology; D003921:Diabetes Mellitus, Experimental / Q000188:drug therapy / Q000209:etiology* / Q000378:metabolism; D005609:Free Radicals; D050356:Lipid Metabolism; D008297:Male; D010084:Oxidation-Reduction; D051381:Rats; D017208:Rats, Wistar
D000975:Antioxidants; D005609:Free Radicals
Svobodnoradikal'nye protsessy v patogeneze alloksanovogo diabeta.