[A new approach to the antibacterial therapy of chronic antral gastritis associated with Helicobacter pylori].
The authors proposed an original method of treatment for antral gastritis associated with Helicobacter pylori and combined with duodenal ulcer. The principle of the method consists in a successive gastric lavage with alkaline and antibacterial (metronidazole) solutions twice a week for a fortnight. Three groups of patients were under observation (37 examinees with chronic antral gastritis associated with Helicobacter pylori and combined with duodenal ulcer). Ten persons who were enlisted into the first group were treated with the lavage only, the second group persons (n = 12) were treated with lavages and histodyl in a dose of 400 mg per night, the third group (n = 15) were orally treated with metronidazole (0.25 g three times a day) for 15 days. A total elimination of Helicobacter pylori was observed in the half of the first group, 2/3 of the second and in 1/3 of the third group. Epithelialization of duodenal ulcers was observed in all those enlisted in the first and second group. Cicatrization of ulcers was observed in half of the patients from the third group.
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D000328:Adult; D002908:Chronic Disease; D003131:Combined Modality Therapy; D004381:Duodenal Ulcer / Q000188:drug therapy / Q000382:microbiology; D005260:Female; D005751:Gastric Lavage; D005756:Gastritis / Q000188:drug therapy* / Q000382:microbiology; D016481:Helicobacter Infections / Q000188:drug therapy* / Q000382:microbiology; D016480:Helicobacter pylori / Q000302:isolation & purification; D006801:Humans; D008297:Male; D008795:Metronidazole / Q000008:administration & dosage*; D008875:Middle Aged; D011706:Pyloric Antrum
D008795:Metronidazole
Novyĭ podkhod k antibakterial'noĭ terapii khronicheskogo antral'nogo gastrita, assotsiirovannogo s Helicobacter pylori.