[Potential genotoxic effects of cytostatics in occupationally-exposed persons].
The aim of the study was to determine possible mutagenic implications of occupational exposure to cytostatic agents. Twenty-one nurses handling antineoplastic drugs and a matching control group were examined. The conventional method for testing chemical mutagens, that of sister chromatid exchanges, SCE, was used. Although the results obtained in the exposed group did not significantly differ from those obtained for the controls, wide ranges of SCE values observed among the medical personnel handling cytostatic drugs confirm the suspicion of the genotoxic effect of those agents.
Brumen
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Institut za medicinska istrazivanja i medicinu rada Sveucilista, Zagreb, Hrvatska.
Horvat
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D000328:Adult; D000970:Antineoplastic Agents / Q000009:adverse effects*; D005260:Female; D006801:Humans; D008875:Middle Aged; D009153:Mutagens; D009726:Nurses; D016273:Occupational Exposure; D012854:Sister Chromatid Exchange / Q000187:drug effects*
D000970:Antineoplastic Agents; D009153:Mutagens
Potencijalni genotoksicni ucinak citostatika na profesionalno izlozeno osoblje.