Alterations of the respiratory minute volume cause changes in muscle oxygenation of rats.
In the anesthetized, open-chest rat, alterations of the respiratory minute volume were induced by changes of the respiratory frequency. Mean tissue pO2 of skeletal muscle in healthy and distressed rats did not change significantly. 10 minutes after a ventilation stop lasting 60 seconds, healthy rats showed an approximately normalized pO2 histogram, whereas distressed rats did not seem to recover. The results indicate an independent regulation mechanism which maintains a sufficient oxygen supply to skeletal tissue of anesthetized rats. The efficacy of this mechanism seemed to be reduced in distressed rats after the ventilation stop.
Günderoth
M
M
University of Tübingen, Medical Hospital I, FRG.
D000818:Animals; D001794:Blood Pressure; D006339:Heart Rate; D008297:Male; D009132:Muscles / Q000378:metabolism*; D010101:Oxygen Consumption; D010313:Partial Pressure; D051381:Rats; D017207:Rats, Sprague-Dawley; D012016:Reference Values; D012119:Respiration / Q000502:physiology*; D012131:Respiratory Insufficiency / Q000378:metabolism / Q000503:physiopathology*; D014655:Vascular Resistance