Immunosuppressive activity of tyrosine analogues of cyclolinopeptide A.
Immunosuppressive properties of six tyrosine analogues of cyclolinopeptide A were studied and compared with the activity of cyclosporin A. The peptides were investigated using PFC (in vitro) and DTH tests.
Wieczorek
Z
Z
Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, Wrocław.
Pedyczak
A
A
Bodalski
T
T
Lisowski
M
M
Trojnar
J
J
Zimecki
M
M
Siemion
I Z
IZ
D000595:Amino Acid Sequence; D000818:Animals; D016572:Cyclosporine / Q000494:pharmacology; D006462:Hemolytic Plaque Technique; D006801:Humans; D006968:Hypersensitivity, Delayed; D007166:Immunosuppressive Agents / Q000737:chemistry / Q000494:pharmacology* / Q000633:toxicity; D066298:In Vitro Techniques; D008214:Lymphocytes / Q000187:drug effects; D051379:Mice; D008808:Mice, Inbred CBA; D008969:Molecular Sequence Data; D010456:Peptides, Cyclic / Q000737:chemistry / Q000494:pharmacology* / Q000633:toxicity; D013329:Structure-Activity Relationship
D007166:Immunosuppressive Agents; D010456:Peptides, Cyclic; C055018:cyclolinopeptide A; D016572:Cyclosporine