Sequence alignment of the G-protein coupled receptor superfamily.
The multitude of G-protein coupled receptor (GPR) superfamily cDNAs recently isolated has exceeded the number of receptor subtypes anticipated by pharmacological studies. Analysis of the sequence similarities and unique features of the members of this family is valuable for designing strategies to isolate related cDNAs, for developing hypotheses concerning substrate-ligand and receptor-effector interactions, and for understanding the evolution of these genes. We have compiled and aligned the 74 unique amino acid sequences published to date and review the present understanding of the structural motifs contributing to ligand binding and G-protein coupling.
Probst
W C
WC
Fishberg Research Center for Neurobiology, Mount Sinai School of Medicine, New York 10029.
Snyder
L A
LA
Schuster
D I
DI
Brosius
J
J
Sealfon
S C
SC
D000595:Amino Acid Sequence; D000818:Animals; D019204:GTP-Binding Proteins; D006801:Humans; D008969:Molecular Sequence Data; D005810:Multigene Family; D011956:Receptors, Cell Surface; D016415:Sequence Alignment
D011956:Receptors, Cell Surface; D019204:GTP-Binding Proteins