title: Hepatic changes in P. falciparum malaria.
abstract: Liver function tests were performed in 165 hospitalized patients suffering from P. falciparum malaria with complications. Serum bilirubin was found increased in 33 patients, and 22 of them had unconjugated hyperbilirubinaemia. Serum alanine aminotransferase was increased in 5 patients, but only to mild to moderate levels. Serum alkaline phosphatase was increased in 11 patients, gamma-glutamyl transpeptidase in 3 patients. Serum total protein and albumin were significantly decreased but these were considered more as indicator of acute phase response. Liver cell necrosis was observed in one patient, and oedema and mononuclear cell infiltration in two patients. Though hepatomegaly and mild elevation of enzymes can be observed in a significant proportion of patients, involvement of liver leading to acute hepatitis or liver cell necrosis is a relatively uncommon complication in P. falciparum malaria.
authors.affiliation: Department of Internal Medicine, Ispat General Hospital Rourkela, India.
authors.forename: S K
authors.initials: SK
authors.lastname: Mishra
authors.forename: S
authors.initials: S
authors.lastname: Mohanty
authors.forename: B S
authors.initials: BS
authors.lastname: Das
authors.forename: J K
authors.initials: JK
authors.lastname: Patnaik
authors.forename: S K
authors.initials: SK
authors.lastname: Satpathy
authors.forename: D
authors.initials: D
authors.lastname: Mohanty
authors.forename: T K
authors.initials: TK
authors.lastname: Bose
mesh_terms: D000293:Adolescent; D000328:Adult; D000410:Alanine Transaminase / Q000097:blood; D000469:Alkaline Phosphatase / Q000097:blood; D001219:Aspartate Aminotransferases / Q000097:blood; D005260:Female; D006760:Hospitalization; D006801:Humans; D006932:Hyperbilirubinemia / Q000209:etiology; D008107:Liver Diseases / Q000209:etiology*; D008111:Liver Function Tests; D016778:Malaria, Falciparum / Q000150:complications*; D008297:Male; D008875:Middle Aged
chemical_list: D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase; D000469:Alkaline Phosphatase