title: Induction of anti-Escherichia coli activity in mice by phenothiazines, benzo[a]phenothiazines and benz[c]acridines.
abstract: The abilities of 14 phenothiazines, 8 benzo[a]phenothiazines and 12 benz[c]acridines to induce anti-Escherichia coli activity in mice were compared. Pretreatment with several benzo[a]phenothiazines or benz[c]acridines protected mice from lethal infection of Escherichia coli in a dose-dependent manner, whereas most of the phenothiazines induced much weaker anti-Escherichia coli activity. However, direct contact of Escherichia coli with these compounds or their administration just after bacterial inoculation were ineffective. These data suggest the immunopotentiation activity of benzo[a]phenothiazines and benz[c]acridines.
authors.affiliation: Department of Medicinal Chemistry, Meiji College of Pharmacy, Tokyo, Japan.
authors.forename: N
authors.initials: N
authors.lastname: Motohashi
authors.forename: H
authors.initials: H
authors.lastname: Sakagami
authors.forename: N
authors.initials: N
authors.lastname: Komatsu
authors.forename: M
authors.initials: M
authors.lastname: Fujimaki
authors.forename: C
authors.initials: C
authors.lastname: Wada
authors.forename: J
authors.initials: J
authors.lastname: Molnar
mesh_terms: D000166:Acridines / Q000494:pharmacology*; D000276:Adjuvants, Immunologic / Q000494:pharmacology*; D000818:Animals; D004926:Escherichia coli; D004927:Escherichia coli Infections / Q000276:immunology / Q000517:prevention & control; D051379:Mice; D008813:Mice, Inbred ICR / Q000276:immunology; D010640:Phenothiazines / Q000494:pharmacology*
chemical_list: D000166:Acridines; D000276:Adjuvants, Immunologic; D010640:Phenothiazines; C035985:benz(c)acridine