title: Clinical outcome in aggressively treated meningeal gliomatosis.
abstract: We reviewed 11 consecutive patients with an antemortem cytologic diagnosis of meningeal gliomatosis. In three patients, meningeal gliomatosis was diagnosed before surgical resection of the glioma. Three of five patients with anaplastic astrocytoma and one with oligodendroglioma improved with treatment. Patients with glioblastoma multiforme did not respond and had a median survival from the diagnosis of meningeal gliomatosis of only 8 weeks. Meningeal gliomatosis can be an early finding in gliomas. Treatment response is probably related to tumor histology and grade.
authors.affiliation: Department of Neurology, University of Michigan Medical Center, Ann Arbor 48109-0316.
authors.forename: R
authors.initials: R
authors.lastname: Grant
authors.forename: B
authors.initials: B
authors.lastname: Naylor
authors.forename: L
authors.initials: L
authors.lastname: Junck
authors.forename: H S
authors.initials: HS
authors.lastname: Greenberg
mesh_terms: D000293:Adolescent; D000328:Adult; D001254:Astrocytoma / Q000473:pathology; D001932:Brain Neoplasms / Q000401:mortality / Q000473:pathology* / Q000628:therapy; D002555:Cerebrospinal Fluid / Q000166:cytology; D003131:Combined Modality Therapy; D005260:Female; D005909:Glioblastoma / Q000473:pathology; D005910:Glioma / Q000401:mortality / Q000473:pathology* / Q000628:therapy; D006801:Humans; D008297:Male; D008578:Meninges / Q000473:pathology*; D008727:Methotrexate / Q000009:adverse effects / Q000627:therapeutic use; D008875:Middle Aged; D009457:Neuroglia / Q000473:pathology*; D009837:Oligodendroglioma / Q000473:pathology; D016019:Survival Analysis
chemical_list: D008727:Methotrexate