title: High-risk coronary angioplasty using percutaneous cardiopulmonary bypass support.
abstract: BACKGROUND
  Balloon angioplasty has a high success rate but results in abrupt closure of the vessel in 2% to 6% of patients. This can lead to haemodynamic collapse and death, particularly if the patient has poor left ventricular function. In the event of abrupt closure of the coronary vessels, such patients may not survive long enough to undergo emergency bypass surgery. The prophylactic use of cardiopulmonary bypass to support patients at high-risk for angioplasty has been reported recently. We describe our initial experience with this technique.
  
  
  METHODS
  Eighteen high-risk patients with severe angina were subjected to balloon angioplasty after instituting percutaneous cardiopulmonary bypass support to enhance the safety of high-risk elective coronary angioplasty. All patients had a low ejection fraction, a large amount of viable myocardium perfused by the targeted artery or both (left ventricular ejection fraction < 25% in 13 patients). Triple-vessel disease was present in all of them. Angioplasty of the only remaining vessel was done in 12 patients, 2 vessels in 5 patients and a sequential graft in 1 patient. Bypass flow ranged from 2.8 to 4.5 litres and was discontinued after a mean of 35 minutes. Haemostasis was achieved by external clamp compression in 16 patients.
  
  
  RESULTS
  The angioplasty was successfully performed in all the patients and was well tolerated. During the bypass period, the pulmonary artery diastolic pressure ranged from 0 to 8 mmHg. There was no hospital death. Two patients required surgical exploration of the femoral artery puncture site--one because of poor distal perfusion and the other for continued bleeding. During the follow up period of 1 to 10 months, 11 patients were free of angina and 1 had died.
  
  
  CONCLUSIONS
  Our experience confirms that percutaneous bypass support in selected patients undergoing high-risk coronary angioplasty is safe and effective.
authors.affiliation: Cardiothoracic Centre, All India Institute of Medical Sciences, New Delhi.
authors.forename: U
authors.initials: U
authors.lastname: Kaul
authors.forename: M
authors.initials: M
authors.lastname: Sharma
authors.forename: V K
authors.initials: VK
authors.lastname: Bahl
authors.forename: V
authors.initials: V
authors.lastname: Dev
authors.forename: H S
authors.initials: HS
authors.lastname: Wasir
authors.forename: P
authors.initials: P
authors.lastname: Venugopal
mesh_terms: D000328:Adult; D000368:Aged; D015906:Angioplasty, Balloon, Coronary / Q000379:methods*; D002315:Cardiopulmonary Bypass / Q000379:methods; D003327:Coronary Disease / Q000503:physiopathology / Q000601:surgery; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D012307:Risk Factors; D016277:Ventricular Function, Left