[The correction of functional disorders of the hemostatic system and of the rheological properties of the blood in dogs in the late period of hemorrhagic shock by the intravenous transfusion of lactoprotein].
In 9 dogs with severe hemorrhagic shock, the effect of hemocorrector "Lactoprotein" on the indices of coagulative hemostasis and rheologic blood properties was studied. It was established that in intravenous transfusion of lactoprotein at a dose of 10 ml/kg permitting to lead the animals out from the state of shock, the syndromes of disseminated intravascular coagulation and high viscosity of the blood were cupped off. However, by the end of 48 hours of observation, fibrinogen level in the blood of the animals increased sharply, while antithrombin-III concentration and hematocrit decreased. Together with recommendation to use lactoprotein in the complex of shock therapy at all the stages of medical evacuation, the conclusion about necessity to perform at the early postshock period the differential component hemo- and anticoagulative therapy has been made.
Oborin
A N
AN
Uspenskiĭ
B A
BA
Kondratskiĭ
B A
BA
Mindiuk
M V
MV
D000418:Albumins / Q000008:administration & dosage*; D000818:Animals; D001778:Blood Coagulation Disorders / Q000097:blood / Q000628:therapy*; D001809:Blood Viscosity / Q000187:drug effects*; D004285:Dogs; D004338:Drug Combinations; D004353:Drug Evaluation, Preclinical; D005260:Female; D005947:Glucose / Q000008:administration & dosage; D007262:Infusions, Intravenous; D007773:Lactates / Q000008:administration & dosage; D019344:Lactic Acid; D008297:Male; D010952:Plasma Substitutes / Q000008:administration & dosage*; D012771:Shock, Hemorrhagic / Q000097:blood / Q000628:therapy*; D013997:Time Factors
D000418:Albumins; D004338:Drug Combinations; D007773:Lactates; D010952:Plasma Substitutes; D019344:Lactic Acid; D005947:Glucose
Korrektsiia funktsional'nykh narusheniĭ sistemy gemostaza i reologicheskikh svoĭstv krovi u sobak v pozdnem periode gemorragicheskogo shoka posredstvom vnutrivennoĭ transfuzii laktoproteina.