Follicular dendritic cell-B cell interactions in virus disease. Common localization but different cell damage caused by antibody immobilized virus?
Follicular dendritic cells (FDC) are involved in the trapping and retention of antigen-antibody complexes in lymphoid follicles. This FDC immobilized antigen is thought to be involved in the generation of memory B-lymphocytes. Follicular trapping of both Aleutian disease virus and HIV particles has been demonstrated. However as far as known their affects on FDC and follicular B-cells are completely different. It is hypothesized that the trapping of (antibody-complexed) virus particles by the FDC-network may have an important role in several virus diseases.
van Rooijen
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Department of Cell Biology, Free University, Amsterdam, The Netherlands.
D000454:Aleutian Mink Disease Virus / Q000276:immunology*; D000914:Antibodies, Viral / Q000276:immunology; D001402:B-Lymphocytes / Q000276:immunology*; D003713:Dendritic Cells / Q000276:immunology*; D015658:HIV Infections / Q000276:immunology* / Q000473:pathology; D007156:Immunologic Memory
D000914:Antibodies, Viral