title: Effect of HDL1 infusion on biliary secretion in perfused rat liver.
abstract: The effects of HDL1 lipoprotein infusion on biliary lipid secretion were studied in the in vitro model of rat perfused liver. A strong increase in bile flow was observed during and after lipoprotein infusion. This caused a significant rise in cholesterol, phospholipid and bile salt secretions. However, only the percentage of cholesterol increased with respect to the other bile lipids. The changes observed in the cholesterol/phospholipid molar ratio values of liver membrane subfractions (i.e., liver plasma membrane, mitochondria plus lysosomes and microsomes) isolated from the perfused rat liver after HDL1 administration were not significant.
authors.affiliation: Istituto Superiore di Sanità, Laboratory of Metabolism and Pathological Biochemistry, Rome, Italy.
authors.forename: R
authors.initials: R
authors.lastname: Rivabene
authors.forename: A
authors.initials: A
authors.lastname: Cantafora
authors.forename: C C
authors.initials: CC
authors.lastname: Yan
authors.forename: F
authors.initials: F
authors.lastname: Castellano
authors.forename: G
authors.initials: G
authors.lastname: Bruscalupi
authors.forename: E
authors.initials: E
authors.lastname: Bravo
mesh_terms: D000818:Animals; D001646:Bile / Q000378:metabolism; D001647:Bile Acids and Salts / Q000378:metabolism; D002784:Cholesterol / Q000378:metabolism; D007425:Intracellular Membranes / Q000378:metabolism; D008075:Lipoproteins, HDL / Q000008:administration & dosage / Q000378:metabolism*; D008099:Liver / Q000187:drug effects / Q000378:metabolism*; D008297:Male; D010743:Phospholipids / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar
chemical_list: D001647:Bile Acids and Salts; D008075:Lipoproteins, HDL; D010743:Phospholipids; D002784:Cholesterol