[Application of serum somatomedin C level to assess the disease activity in patients with acromegaly].
Serum SMC level was measured in acromegalic patients with different disease activity. The serum SMC level of 10 untreated and 15 treated patients with active disease was 30.5 +/- 17.6 and 23.8 +/- 16.3 KU/L respectively. These levels were significantly higher than the value 2.7 +/- 2.8 KU/L in 7 patients during remitting state. The serum SMC level correlated with the basal and the nadir GH level and the area under the GH curve in glucose suppression test. The serum SMC levels in 6 patients with prolactinoma, 10 patients with Grave's disease and 8 patients with renal failure were all in normal range, but in 10 patients with liver cirrhosis it was 0.36 +/- 0.39 KU/L, which was significantly lower than the normal value. We concluded that serum SMC level is a good criterion for assessment of disease activity of acromegaly for it does not require a dynamic test and it does not increase in other diseases.
Liu
R
R
Department of Endocrinology, PUMC Hospital, Beijing.
Shi
Y F
YF
Deng
J Y
JY
D000172:Acromegaly / Q000175:diagnosis*; D000328:Adult; D003937:Diagnosis, Differential; D005260:Female; D013006:Growth Hormone / Q000097:blood; D006801:Humans; D007334:Insulin-Like Growth Factor I / Q000032:analysis*; D008297:Male
D007334:Insulin-Like Growth Factor I; D013006:Growth Hormone