[The effect of verapamil and nifedipine on acid-base and electrolyte disorders induced by cholesterol in rabbits].
The influence of cholesterol atherogenic diet on the acid-base balance and electrolyte profile was investigated in rabbit blood and the effect of simultaneous administration of verapamil and nifedipine on the induced changes was evaluated. Cholesterol diet resulted in significant metabolic acidosis, hyperkalemia, and a slight decrease in plasma ionized calcium. On the other hand, longterm treatment with verapamil and nifedipine exhibited their protective effect, with the acid-base status and electrolyte profile maintained within the normal range. The protective effect of verapamil and nifedipine against cholesterol induced acid-base and electrolyte disturbances appears to be associated with their antiatherogenic activity. (Fig. 5, Ref. 10.).
Holub
P
P
Katedra farmakológie a toxikológie FaF UK v Bratislave, CSFR.
Svec
P
P
Edelsteinová
S
S
Lazarová
Z
Z
Drábková
E
E
D000136:Acid-Base Equilibrium / Q000187:drug effects*; D000818:Animals; D002791:Cholesterol, Dietary / Q000009:adverse effects*; D004573:Electrolytes / Q000097:blood*; D008297:Male; D009543:Nifedipine / Q000494:pharmacology*; D011817:Rabbits; D014700:Verapamil / Q000494:pharmacology*
D002791:Cholesterol, Dietary; D004573:Electrolytes; D014700:Verapamil; D009543:Nifedipine
Vplyv verapamilu a nifedipínu na poruchy acidobázy a elektrolytov vyvolané cholesterolom u králikov.