[Antihypertensive effects of atenolol and nitrendipine alone or in combination on three hypertensive models of rats].
The antihypertensive effects of atenolol (Ate) or nitrendipine (Nit) alone or in combination (Ate+Nit) were studied in conscious experimental hypertensive rats. The hypotensive effects of single ig of Ate 20 + Nit 10 mg.kg-1 were rapid and persistent in spontaneously hypertensive rats (SHR). In renovascular hypertensive rats (RVHR) and DOCA-salt hypertensive rats (DHR), Ate+Nit (6 + 3, 20 + 10, 60 + 30 mg.kg-1) given ig once a day for 10 d reduced the blood pressure in a dose-dependent manner. But Ate 20 mg.kg-1 or Nit 10 mg.kg-1 alone given ig once a day for 10 d caused no obvious reduction in blood pressure in RVHR, DHR, and SHR q = 1.32. These results revealed that the synergy is present in the antihypertensive action of Ate+Nit.
Miao
C Y
CY
Department of Pharmacology, Second Military Medical University, Shanghai, China.
Zhu
Q Y
QY
Yang
Y C
YC
Su
D F
DF
D000818:Animals; D001262:Atenolol / Q000008:administration & dosage*; D001794:Blood Pressure / Q000187:drug effects; D003900:Desoxycorticosterone; D004359:Drug Therapy, Combination; D005260:Female; D006973:Hypertension / Q000139:chemically induced / Q000188:drug therapy*; D006978:Hypertension, Renovascular / Q000188:drug therapy; D008297:Male; D009568:Nitrendipine / Q000008:administration & dosage*; D051381:Rats; D011918:Rats, Inbred SHR; D017207:Rats, Sprague-Dawley
D003900:Desoxycorticosterone; D001262:Atenolol; D009568:Nitrendipine