title: [A metabolic study of the synthetic glucocorticosteroids prednisolone and dexamethasone in the body of white rats and in in-vitro reactions].
abstract: The metabolism of the synthetic steroidal hormones prednisolone and dexamethasone was studied in albino rats and in in vitro microsomal oxidation system by using high performance chromatography and radioactive tracers. Dexamethasone was found to be metabolically stable. The first step of prednisolone biotransformation is formation of prednisone during the NADPH-dependent reaction catalyzed by microsomal enzymes. Conditions were created for isolating the ultimate prednisolone metabolite formed in the rats' body by using HPLC.
authors.forename: D S
authors.initials: DS
authors.lastname: Maruzhenkov
authors.forename: E Iu
authors.initials: EIu
authors.lastname: Krynetskiĭ
authors.forename: B S
authors.initials: BS
authors.lastname: Prokhorov
authors.forename: Iu F
authors.initials: IuF
authors.lastname: Krylov
mesh_terms: D000818:Animals; D001711:Biotransformation; D002851:Chromatography, High Pressure Liquid / Q000379:methods; D002855:Chromatography, Thin Layer / Q000379:methods; D003907:Dexamethasone / Q000493:pharmacokinetics* / Q000652:urine; D066298:In Vitro Techniques; D008297:Male; D008862:Microsomes, Liver / Q000201:enzymology; D011239:Prednisolone / Q000493:pharmacokinetics* / Q000652:urine; D051381:Rats; D017208:Rats, Wistar; D012588:Scintillation Counting; D014316:Tritium
chemical_list: D014316:Tritium; D003907:Dexamethasone; D011239:Prednisolone
vernacular_title: Izuchenie metabolizma sinteticheskikh gliukokortikosteroidov prednizolona i deksametazona v organizme belykh krys i v reaktsiiakh in vitro.