Effect of continuous, long-term administrations of acetylsalicylic acid on hematological and hemocoagulation changes in the rat.
Acetylsalicylic acid is currently being widely used either itself or in combination with the other substances for the prevention of thromboembolic events. Its effect is particularly given by the inhibition of the cyclooxygenase enzyme participating in the metabolism of eicosanoids. The recommended doses of acetylsalicylic acid as well as frequency of administrations are very different. The present work is aimed at estimating the effect of the continuous administration of acetylsalicylic acid for 28 days on hematological and hemocoagulation changes in the rat. The experimental results suggest that long-term administrations of acetylsalicylic acid should be used cautiously in human medicine. They signalize the need of long-term, aimed clinical studies of hematological parameters of patients preventively treated with acetylsalicylic acid, also with respect to the producer of this substance. It is also impossible to neglect regular controls of necessary parameters for the estimation of the efficiency of the given therapy in each patient with respect to individual reactions. The dosage should also be adjusted with respect to the age, sex and individual sensitivity of the organism.
Navrátil
L
L
Institute of Biophysics, First Medical Faculty, Charles University, Prague.
Blehová
Z
Z
Drbohlavová
H
H
D000818:Animals; D001241:Aspirin / Q000008:administration & dosage / Q000097:blood* / Q000494:pharmacology; D001772:Blood Cell Count / Q000187:drug effects*; D001777:Blood Coagulation / Q000187:drug effects*; D005260:Female; D051381:Rats; D017208:Rats, Wistar; D013997:Time Factors
D001241:Aspirin