title: The effects of hypoxia on the ventilatory response to sudden changes in CO2 in newborn piglets.
abstract: 1. The ventilatory response to square-wave challenges in end-tidal partial pressure of CO2 (PCO2) was investigated at three levels of arterial PO2 (Pa,O2) in nineteen anaesthetized 2- to 11-day-old piglets. 2. The ventilatory responses, measured on a breath-to-breath basis, were separated into a peripheral and a central component using a two-compartment model. Both components were described by a CO2 sensitivity, a time constant, a time delay and a single offset. 3. Fifty-six responses were analysed against a background of normoxaemia (Pa,O2 = 12.70 +/- 0.72 kPa, mean +/- S.D.), fifty-three against a background of moderate hypoxaemia (Pa,O2 = 8.63 +/- 0.34 kPa) and fifty-one against a background of severe hypoxaemia (Pa,O2 = 4.98 +/- 0.30 kPa). 4. The sensitivity of the peripheral chemoreceptors in mediating the response to CO2 increased from 38.3 +/- 17.0 ml min-1 kPa-1 kg-1 during normoxaemia to 48.8 +/- 15.3 ml min-1 kPa-1 kg-1 during moderate hypoxaemia and to 72.9 +/- 24.0 ml min-1 kPa-1 kg-1 at severe hypoxaemia. 5. As compared with the central CO2 sensitivity during moderate hypoxaemia and normoxaemia (104.0 +/- 39.0 and 100.8 +/- 41.6 ml min-1 kPa-1 kg-1, respectively) it decreased to 85.9 +/- 54.1 ml min-1 kPa-1 kg-1 at severe hypoxaemia. 6. We conclude that in newborn piglets there is a positive interaction between hypoxia and hypercapnia at the level of the peripheral chemoreceptors while severe hypoxaemia reduced the CO2 sensitivity centrally.
authors.affiliation: Department of Physiology, University of Leiden, The Netherlands.
authors.forename: J G
authors.initials: JG
authors.lastname: Wolsink
authors.forename: A
authors.initials: A
authors.lastname: Berkenbosch
authors.forename: J
authors.initials: J
authors.lastname: DeGoede
authors.forename: C N
authors.initials: CN
authors.lastname: Olievier
mesh_terms: D000818:Animals; D000831:Animals, Newborn / Q000502:physiology*; D002245:Carbon Dioxide / Q000502:physiology*; D005260:Female; D008297:Male; D008433:Mathematics; D010100:Oxygen / Q000097:blood*; D012119:Respiration / Q000502:physiology*; D013552:Swine; D013997:Time Factors
chemical_list: D002245:Carbon Dioxide; D010100:Oxygen