Rheological leukocyte indexes in diabetes mellitus type II.
Eleven healthy volunteers were examined, as well a thirty-five diabetic subjects divided into three groups according to the presence or absence of macro-microvascular complications and according to whether or not these complications were chronic. The results of our study show a marked unfavorable in cell rheology in the diabetic subjects, as studied using the St. George filtrometer. In particular, polymorphonuclear (PMN) cells, in the diabetic subject showed a substantial decreases in viscosity and elasticity, reflected by decreased IrFr and increased CR values. These changes were most marked in the group of diabetics with acute vascular events, i.e., AMI and stroke. Rheological indexes studied appeared to be independent from the simultaneous blood glucose level.
Perego
M A
MA
Medical Unit 2, Policlinico Umberto 1, Roma, Italia.
Danese
C
C
Volpe
M S
MS
Zavattaro
E
E
Calisi
L
L
D000368:Aged; D000369:Aged, 80 and over; D001809:Blood Viscosity; D003924:Diabetes Mellitus, Type 2 / Q000097:blood* / Q000150:complications; D003925:Diabetic Angiopathies / Q000097:blood* / Q000209:etiology; D004548:Elasticity; D005260:Female; D006801:Humans; D007962:Leukocytes; D008297:Male; D008875:Middle Aged; D009504:Neutrophils; D012212:Rheology