[The efficacy of immunomodulating preparations in treating patients with chronic cholestatic liver diseases].
A study of 102 patients with chronic cholestatic liver diseases revealed that levamisole, T + activin and thymalin possess an immunostimulating effect increasing the level of lymphocytes, T-lymphocytes, activate the functional activity of lymphocytes in patients with chronic cholestatic hepatitis and primary biliary cirrhosis. T = activin, thymalin produce a more pronounced normalization of the immune response by increasing the contents of T-lymphocytes and their subpopulations, elevating the functional activity of mononuclears, reducing the concentration of immunoglobulins, cyclic immune complexes. These changes favour controlling the immuno-inflammatory process in the liver, normalization of clinical manifestation of the disease.
Radchenko
V G
VG
Mitrofanova
T I
TI
Serebriakova
V I
VI
Vinogradova
G L
GL
D000276:Adjuvants, Immunologic / Q000627:therapeutic use*; D000328:Adult; D000368:Aged; D002779:Cholestasis / Q000188:drug therapy* / Q000276:immunology; D002908:Chronic Disease; D003131:Combined Modality Therapy; D004341:Drug Evaluation; D005260:Female; D006801:Humans; D007978:Levamisole / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged; D010455:Peptides / Q000627:therapeutic use; D013949:Thymus Extracts / Q000627:therapeutic use; D013951:Thymus Hormones / Q000627:therapeutic use
D000276:Adjuvants, Immunologic; D010455:Peptides; D013949:Thymus Extracts; D013951:Thymus Hormones; D007978:Levamisole; C032805:thymalin; C036191:T-activin
Effektivnost' nekotorykh immunomoduliruiushchikh preparatov v lechenii bol'nykh khronicheskimi kholestaticheskimi zabolevaniiami pecheni.