[The importance of detection of antigliadin antibodies in the diagnosis and therapy of celiac disease in children].
The authors describe the method of assessment of antigliadin antibodies class IgA and IgG by the ELISA method. In a group of children with untreated coeliac disease the antigliadin antibodies were elevated in 91.6%, in a group of children with coeliac disease after exposure to gluten in 87.8%, in children on a gluten-free regime in 48.5%. The dynamics of antigliadin antibodies in the course of the first year are presented--their decline in serum of children suffering from acute coeliac disease after elimination of gluten and conversely their rise after discontinuation of the gluten-free diet in children previously treated for prolonged periods. The sensitivity of the assessment is 91.6% and the specificity 90.6%.
Kolek
A
A
Dĕtská klinika FNsP, Olomouc.
Lochmann
I
I
Tichý
M
M
D000293:Adolescent; D000906:Antibodies / Q000032:analysis*; D002446:Celiac Disease / Q000175:diagnosis / Q000178:diet therapy / Q000276:immunology*; D002648:Child; D002675:Child, Preschool; D005903:Gliadin / Q000276:immunology*; D006801:Humans; D007070:Immunoglobulin A / Q000032:analysis; D007074:Immunoglobulin G / Q000032:analysis; D007223:Infant
D000906:Antibodies; D007070:Immunoglobulin A; D007074:Immunoglobulin G; D005903:Gliadin
Význam vysetrení antigliadinových protilátek pro diagnostiku a lécbu celiakie u dĕtí.