title: The phenotype and gene frequencies of human platelet specific antigens among Chinese in Taiwan.
abstract: Human platelet specific antigens (HPA) were serologically typed among 48 to 567 samples of blood from Chinese in Taiwan by using the mixed passive hemag-glutination method (MPHA). The prevalence found was: HPA-la (P1A1), > 99.9% (48/48); HPA-2b (Koa or Siba), 9.0% (51/567); HPA-3a (Baka), 84.8% (481/567); HPA-4a (Yukb), > 99.9% (567/567); HPA-4b (Yuka), 0.5% (3/567); HPA-5b (Br(a)), 32.6% (185/567); and Nak(a), 98.4% (558/567). The gene frequencies for these antigens were: HPA-la (P1A1), > 0.999; HPA-2b (Koa or Siba), 0.046; HPA-3a (Bak(a)), 0.611; HPA-4a (Yukb), 0.997; HPA-4b (Yuka), 0.003; HPA-5b (Br(a)), 0.179; and Nak(a), 0.874. The distribution of HPA's for Chinese differ from those for Caucasians and for Japanese. When compared to Caucasians, Chinese show a higher prevalence of HPA-la (P1A1), higher prevalence of HPA-5b (Br(a)), lower prevalence of HPA-2b (Koa or Siba) and lower prevalence of HPA-3a (Baka). Both Chinese and Japanese have a very high prevalence rate of HPA-la (P1A1), ie. close to 100%. However, the prevalence of HPA 2-2b (Koa or Siba) and HPA-4b (Yuka) is slightly lower in Chinese than in Japanese; and, the prevalence rate for HPA-3a (Baka) is slightly higher in Chinese than in Japanese.
authors.affiliation: Department of Clinical Pathology, Chang Gung Memorial Hospital, Taipei, Taiwan.
authors.forename: K C
authors.initials: KC
authors.lastname: Tsao
authors.forename: C F
authors.initials: CF
authors.lastname: Sun
authors.forename: N C
authors.initials: NC
authors.lastname: Lai
mesh_terms: D016824:Antigens, Human Platelet / Q000235:genetics*; D044466:Asian People; D002681:China / Q000208:ethnology; D005787:Gene Frequency; D006801:Humans; D010641:Phenotype; D013624:Taiwan; D044465:White People
chemical_list: D016824:Antigens, Human Platelet