title: Effect of glyceryl trinitrate on proximal stomach musculature in normal volunteers.
abstract: The effect of GTN on stomach is unknown although there is evidence that nitric oxide, the active component of GTN have a mediator role in the upper gastrointestinal tract. By the use of a newly developed barostat technique it was investigated the effect of GTN on gastric fundal tone and contractions.
  
  
  METHODS
  measurements were done 1 hour before an 1 hour after the administration of either 500 micrograms sublingual GTN and 5 mg buccal GTN or a placebo in 7 healthy individuals (14 experiments) by recording variations in the volume of air within an intragastric bag that was maintained at a constant pressure of 12 mmHg by the barostat.
  
  
  RESULTS
  a significant increase in intrabag volume of 99.74 +/- 28.34 ml (mean +/- SEM) (p < 0.01) was recorded after GTN administration; a not significant (p > 0.01) increase in volume of 24.34 +/- 16.23 ml was after placebo. There was no significant difference between the frequency of contractions before and after drug or placebo administration.
  
  
  CONCLUSIONS
  after systemic and constant administration of GTN a constant reduction in gastric fundal tone is produced with no change of fundal contractions.
authors.affiliation: University Medical School of Iasi, Romania.
authors.forename: T P
authors.initials: TP
authors.lastname: Toma
authors.forename: D G
authors.initials: DG
authors.lastname: Thompson
authors.forename: L
authors.initials: L
authors.lastname: Troncon
authors.forename: N K
authors.initials: NK
authors.lastname: Ahuwalia
mesh_terms: D000328:Adult; D005748:Gastric Fundus; D006801:Humans; D008365:Manometry / Q000295:instrumentation / Q000379:methods; D009119:Muscle Contraction / Q000187:drug effects; D005996:Nitroglycerin / Q000494:pharmacology*; D011897:Random Allocation; D012016:Reference Values; D016037:Single-Blind Method; D013270:Stomach / Q000187:drug effects* / Q000502:physiology
chemical_list: D005996:Nitroglycerin