title: Effects of phenytoin on dental caries and plaque in Streptococcus sobrinus-infected rats.
abstract: Effects of phenytoin (PHT) administration on dental caries in rats infected with Streptococcus sobrinus 6715 were investigated. Twenty-day-old specific pathogen-free Fischer male rats were infected with S. sobrinus 6715 and fed diet 2000 containing 56% sucrose with or without PHT for 52 days. Antibody responses against anti-S. sobrinus in serum and saliva failed to show a statistical difference between PHT-treated and nontreated rats. These results indicate that PHT treatment increased plaque deposition and dental caries in the rats infected with S. sobrinus 6715 and fed diet 2000 containing PHT (1-2 mg/g), as compared with those similarly infected and fed diet without PHT (P < 0.001).
authors.affiliation: Osaka University, Faculty of Dentistry, Japan.
authors.forename: I
authors.initials: I
authors.lastname: Morisaki
authors.forename: J P
authors.initials: JP
authors.lastname: Loyola-Rodríguez
authors.forename: C
authors.initials: C
authors.lastname: Adachi
authors.forename: S
authors.initials: S
authors.lastname: Hamada
mesh_terms: D000818:Animals; D000907:Antibodies, Bacterial / Q000097:blood; D001835:Body Weight; D003731:Dental Caries / Q000209:etiology* / Q000382:microbiology; D003774:Dental Plaque Index; D004037:Diet, Cariogenic; D008297:Male; D010672:Phenytoin / Q000009:adverse effects*; D051381:Rats; D011916:Rats, Inbred F344; D013047:Specific Pathogen-Free Organisms; D016986:Streptococcus sobrinus / Q000276:immunology / Q000472:pathogenicity
chemical_list: D000907:Antibodies, Bacterial; D010672:Phenytoin