title: Induction of tumours of the haematopoietic system by cadmium in rats.
abstract: Several of our recent studies in rats indicate an association between exposure to cadmium and haematopoietic tumours. In the first study, male WF rats received dietary cadmium (0-200 micrograms/g cadmium as cadmium chloride) for up to 77 weeks. A dose-related increase in large granular lymphocyte (LGL) leukaemia was observed with a maximal incidence in rats fed 100 micrograms/g cadmium. In a second study, male F344 rats received a single high dose of cadmium chloride (30 mumol/kg, s.c.) and were observed for 90 weeks. The high natural incidence of leukaemia in these rats (24%) was markedly reduced (6%) by this dose of cadmium. The paradoxical effects of cadmium on haematopoietic tumours may be the result of a dose-related spectrum of lymphotoxicity ranging from cell-specific cytotoxicity and carcinogenicity to destruction of key progenitor cell populations.
authors.affiliation: Inorganic Carcinogenesis Section, Frederick Cancer Research and Development Center, MD 21702.
authors.forename: M P
authors.initials: MP
authors.lastname: Waalkes
authors.forename: S
authors.initials: S
authors.lastname: Rehm
authors.forename: B
authors.initials: B
authors.lastname: Sass
authors.forename: J M
authors.initials: JM
authors.lastname: Ward
mesh_terms: D000818:Animals; D002104:Cadmium / Q000633:toxicity*; D006402:Hematologic Diseases / Q000139:chemically induced*; D007945:Leukemia, Lymphoid / Q000139:chemically induced; D008297:Male; D009374:Neoplasms, Experimental / Q000139:chemically induced*; D051381:Rats; D011916:Rats, Inbred F344; D011920:Rats, Inbred WF
chemical_list: D002104:Cadmium