title: Anesthetic effect of EMLA occluded with Orahesive oral bandages on oral mucosa. A placebo-controlled study.
abstract: The efficiency of a topical anesthetic occluded with Orahesive Oral Bandage was investigated. Experimental pain was provoked by needle insertions into two palatal test areas in 20 healthy subjects. Pain, estimated on a 100-mm visual analogue scale (VAS), decreased significantly from 23.5 mm to 10.5 mm at the greater palatine foramen and from 51.5 mm to 35.0 mm at the incisive foramen after application of a eutectic mixture of local anesthetics (EMLA). No significant change in pain perception was obtained after placebo application. The EMLA cream and the Orahesive Oral Bandages were well accepted by the subjects, as only two out of 20 subjects experienced slight gagging reflexes and only three considered the taste unpleasant. No other adverse reactions were observed. Occlusion of topical anesthetics seems to be a useful technique for achieving superficial mucosal anesthesia.
authors.affiliation: Department of Prosthetic Dentistry and Stomatognathic Physiology, Royal Dental College, University of Aarhus, Denmark.
authors.forename: P
authors.initials: P
authors.lastname: Svensson
authors.forename: J K
authors.initials: JK
authors.lastname: Petersen
mesh_terms: D000287:Administration, Topical; D000328:Adult; D000766:Anesthesia, Dental / Q000379:methods*; D000779:Anesthetics, Local / Q000008:administration & dosage*; D004311:Double-Blind Method; D004338:Drug Combinations; D005260:Female; D005683:Gagging; D006801:Humans; D008012:Lidocaine / Q000008:administration & dosage; D000077442:Lidocaine, Prilocaine Drug Combination; D008297:Male; D009061:Mouth Mucosa / Q000187:drug effects; D009779:Occlusive Dressings / Q000009:adverse effects; D010147:Pain Measurement; D010159:Palate / Q000187:drug effects; D017060:Patient Satisfaction; D011318:Prilocaine / Q000008:administration & dosage
chemical_list: D000779:Anesthetics, Local; D004338:Drug Combinations; D000077442:Lidocaine, Prilocaine Drug Combination; D011318:Prilocaine; D008012:Lidocaine