Effects of dietary fermentable fiber on fatty acid synthesis and triglyceride secretion in rats fed fructose-based diet: studies with sugar-beet fiber.
In an attempt to elucidate the role of the dietary fermentable fiber in reduction of hyperlipidemia, we substituted 30% wheat starch with 30% sugar-beet fiber in rats fed a fructose-based (41% fructose), low-fat (2% corn oil) diet. Male Wistar rats ate the test diets for 3 weeks. Feeding the sugar-beet fiber (SBF) diet resulted in a significant enlargement of the cecum; it also increased the concentration of volatile fatty acids compared with rats fed a fiber-free (FF) diet. Feeding SBF decreased plasma triglyceride and cholesterol concentrations in the postprandial as well as the postabsorptive period. In the liver, triglyceride levels were depressed in concert with the decreased liver lipogenesis and the post-Triton triglyceride secretion. Liver cholesterol levels were unaffected by SBF diet feeding. SBF-fed animals were markedly less fat compared with fiber-free-diet-fed rats. Adipose tissue lipogenesis was depressed in the postprandial period in SBF-fed animals. In short, this study suggests that substitution of easily digested carbohydrates by certain fermentable fibers may play an interesting role in the reduction of hyperlipidemia and obesity.
Mazur
A
A
Laboratoire des Maladies Métaboliques, Institut National de la Recherche Agronomique, St. Genès Champanelle, France.
Gueux
E
E
Felgines
C
C
Bayle
D
D
Nassir
F
F
Demigné
C
C
Rémésy
C
C
D000818:Animals; D002784:Cholesterol / Q000097:blood; D004043:Dietary Fiber / Q000494:pharmacology*; D005227:Fatty Acids / Q000096:biosynthesis*; D005285:Fermentation; D005632:Fructose / Q000494:pharmacology*; D008099:Liver / Q000378:metabolism; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D014280:Triglycerides / Q000097:blood*
D004043:Dietary Fiber; D005227:Fatty Acids; D014280:Triglycerides; D005632:Fructose; D002784:Cholesterol