title: Primary choriocarcinoma of the urinary bladder--a case report.
abstract: We report a primary choriocarcinoma of the urinary bladder in a 63-year-old man who presented with painless hematuria. He was diagnosed as having an invasive carcinoma and underwent a total cystectomy. The tumor was diffusely hemorrhagic and occupied the dome of the bladder. Histologically, it consisted of cyto-and syncytiotrophoblasts with extensive hemorrhage. No coexisting transitional cell carcinoma component was present. By immunohistochemistry, the tumor expressed beta-hCG and low-molecular weight cytokeratin intensely while it was negative for CEA or EMA. The post-cystectomy serum beta-hCG was 237mlU/ml, and decreased later. The pertinent literature is reviewed and diagnostic criteria are discussed.
authors.affiliation: Department of Pathology, Asan Medical Center College of Medicine, University of Ulsan, Seoul, Korea.
authors.forename: J H
authors.initials: JH
authors.lastname: Cho
authors.forename: E
authors.initials: E
authors.lastname: Yu
authors.forename: K H
authors.initials: KH
authors.lastname: Kim
authors.forename: I
authors.initials: I
authors.lastname: Lee
mesh_terms: D002822:Choriocarcinoma / Q000473:pathology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D001749:Urinary Bladder Neoplasms / Q000473:pathology*