[In vitro liver microsomal metabolism of antimalarial primaquine].
The profile of the major metabolites of primaquine produced by in vitro liver microsomal metabolism was investigated with silica gel thin-layer and high performance liquid chromatography (HPLC) analysis. The results indicated that the liver microsomal metabolism could simultaneously produce both 5-OH PQ (quinoline ring oxidation product) and CPQ (side-chain oxidative deamination product). However, the quantitative comparative study of microsomal metabolism showed that the production of 5-OH PQ was far much higher than that of CPQ.
Ni
Y C
YC
Institute of Parasitic Diseases, Chinese Academy of Preventive Medicine, Shanghai.
Wang
M J
MJ
Xu
Y Q
YQ
Hu-Ling
D000818:Animals; D002851:Chromatography, High Pressure Liquid / Q000379:methods; D002855:Chromatography, Thin Layer; D066298:In Vitro Techniques; D008862:Microsomes, Liver / Q000378:metabolism*; D011319:Primaquine / Q000378:metabolism*; D051381:Rats
D011319:Primaquine