[The dynamic accumulation of a low-molecular physiologically active depressor factor and its biological effects in hemorrhagic shock].
A low-molecular factor (800-1000 D) was isolated from the blood serum of dogs using selective ultrafiltration. That factor was taken in various terms of the hemorrhagic shock development. Biological activity of the factor was determined in experiments on isolated hearts of dogs and lymphoid cells. It is found that the above factor decreases the contractile function of the isolated heart, disturbs energy formation, inhibits the antibody-forming function of the spleen as well as possesses a cytolytic effect on lymphocytes of the peripheral blood lympho-nodes and thymus.
Tymchenko
A S
AS
Korol'ov
Iu N
IuN
D000818:Animals; D001685:Biological Factors / Q000097:blood* / Q000302:isolation & purification / Q000494:pharmacology; D002850:Chromatography, Gel; D003864:Depression, Chemical; D004285:Dogs; D006321:Heart / Q000187:drug effects / Q000502:physiology; D066298:In Vitro Techniques; D008214:Lymphocytes / Q000187:drug effects / Q000276:immunology; D051379:Mice; D008808:Mice, Inbred CBA; D008970:Molecular Weight; D012771:Shock, Hemorrhagic / Q000097:blood*; D013056:Spectrophotometry, Ultraviolet; D014462:Ultrafiltration
D001685:Biological Factors
Dynamika nakopychennia nyz'komolekuliarnoho fiziolohichno aktyvnoho depresornoho faktoru ta ĭoho biolohichni efekty pry hemorahichnomu shotsi.