Expression of S-100 protein, epithelial membrane antigen, carcinoembryonic antigen and alpha fetoprotein in normal salivary glands and primary salivary gland tumors.
The distribution of S-100 protein, epithelial membrane antigen, carcinoembryonic antigen and alpha fetoprotein was studied in 38 primary salivary gland tumors. S-100 protein, a useful marker of myoepithelial cells, was demonstrated in some benign tumors. Carcinoembryonic antigen expression was consistently positive in adenoid cystic carcinoma. Demonstration of epithelial membrane antigen helped to confirm the epithelial nature of some neoplastic cells. Alpha fetoprotein was not expressed in any of the cases examined. No correlation was found between immunopositivity and tumor behavior in the present series.
Günhan
O
O
Department of Pathology, Gülhane Military Medical Academy and Medical School, Ankara, Turkey.
Evren
G
G
Demiriz
M
M
Can
C
C
Celasun
B
B
Finci
R
R
D000236:Adenoma / Q000737:chemistry; D008949:Adenoma, Pleomorphic / Q000737:chemistry; D000293:Adolescent; D000328:Adult; D000368:Aged; D000951:Antigens, Neoplasm / Q000032:analysis* / Q000235:genetics; D014408:Biomarkers, Tumor / Q000032:analysis*; D002272:Carcinoembryonic Antigen / Q000032:analysis* / Q000235:genetics; D002277:Carcinoma / Q000737:chemistry; D003528:Carcinoma, Adenoid Cystic / Q000737:chemistry; D005260:Female; D015870:Gene Expression; D006801:Humans; D008297:Male; D008562:Membrane Glycoproteins / Q000032:analysis* / Q000235:genetics; D008875:Middle Aged; D018396:Mucin-1; D009418:S100 Proteins / Q000032:analysis* / Q000235:genetics; D012468:Salivary Gland Neoplasms / Q000737:chemistry*; D012469:Salivary Glands / Q000737:chemistry*; D000509:alpha-Fetoproteins / Q000032:analysis* / Q000235:genetics
D000951:Antigens, Neoplasm; D014408:Biomarkers, Tumor; D002272:Carcinoembryonic Antigen; D008562:Membrane Glycoproteins; D018396:Mucin-1; D009418:S100 Proteins; D000509:alpha-Fetoproteins