title: Bone marrow necrosis and human parvovirus associated infection preceding an Ph1+ acute lymphoblastic leukemia.
abstract: A case of bone marrow necrosis associated with a serologically documented recent Parvovirus B 19 infection which preceded the development of PH1+ acute lymphoblastic leukemia is reported. No conclusions can be drawn on the basis of a single case but the question of the role of human Parvovirus B19 in the pathogenesis of bone marrow necrosis is discussed. It is suggested that the virus may act as a co-factor for the induction of bone marrow necrosis, in some cases.
authors.affiliation: Department of Pathology, Faculty of Medicine, Dijon, France.
authors.forename: T
authors.initials: T
authors.lastname: Petrella
authors.forename: F
authors.initials: F
authors.lastname: Bailly
authors.forename: F
authors.initials: F
authors.lastname: Mugneret
authors.forename: D
authors.initials: D
authors.lastname: Caillot
authors.forename: P
authors.initials: P
authors.lastname: Chavanet
authors.forename: H
authors.initials: H
authors.lastname: Guy
authors.forename: E
authors.initials: E
authors.lastname: Solary
authors.forename: A
authors.initials: A
authors.lastname: Waldner
authors.forename: E
authors.initials: E
authors.lastname: Devilliers
authors.forename: P M
authors.initials: PM
authors.lastname: Carli
mesh_terms: D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D001853:Bone Marrow / Q000473:pathology*; D003520:Cyclophosphamide / Q000008:administration & dosage; D003630:Daunorubicin / Q000008:administration & dosage / Q000031:analogs & derivatives; D016731:Erythema Infectiosum / Q000150:complications*; D005260:Female; D006801:Humans; D007621:Karyotyping; D008727:Methotrexate / Q000008:administration & dosage; D010198:Pancytopenia / Q000209:etiology; D016732:Parvovirus B19, Human / Q000472:pathogenicity*; D010677:Philadelphia Chromosome; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000150:complications* / Q000188:drug therapy; D011379:Prognosis; D012074:Remission Induction; D013256:Steroids / Q000008:administration & dosage; D014750:Vincristine / Q000008:administration & dosage
chemical_list: D013256:Steroids; D014750:Vincristine; D003520:Cyclophosphamide; D008727:Methotrexate; D003630:Daunorubicin