[A study of the antiarrhythmic mechanism of berberine on delayed activation potassium current by voltage clamp].
The effects of berberine (0.1-10 mg/L) on delayed activation potassium current (iK) of canine Purkinje fibers were studied with two-microelectrode voltage clamp technique. Berberine (Ber) significantly reduced the amplitude of iK in concentration-dependent manner. When perfused with 10 mg/L Ber, the amplitude of tail current of the Purkinje fibers decreased immediately and the inhibition rate was 73.6 +/- 4.5% (n = 9, P < 0.001). The inhibition effect of berberine on iK may explain its prolongation effect on action potential duration and its antiarrhythmic action.
Huang
W M
WM
Shanghai Xu Hui District Central Hospital.
D000200:Action Potentials / Q000187:drug effects; D000818:Animals; D000889:Anti-Arrhythmia Agents / Q000494:pharmacology*; D001599:Berberine / Q000494:pharmacology*; D004285:Dogs; D006321:Heart / Q000502:physiology; D066298:In Vitro Techniques; D015221:Potassium Channels / Q000187:drug effects*; D011690:Purkinje Fibers / Q000187:drug effects
D000889:Anti-Arrhythmia Agents; D015221:Potassium Channels; D001599:Berberine