[The central mechanism of the immunomodulating action of vasopressin and its structural analogs].
It is shown that the effect of neuropeptides depends on the dose and their structure. Considerable immunostimulation is observed after administration of [8-arginine]vasopressin and des-9-glucine-[8-arginine]vasopressin as against the control. This stimulation is prevented by the preliminary heloperidol blockade of dopaminergic receptors, i.e. it is dopamine-dependent. At the same time, injection of tetrapeptide vesopressin-(2-5) induces deep immunosuppression in all the applied doses. The peptide immunosuppression is shown to be a result of interaction with another neuromediator (serotoninergic); it has no effect under preliminary cuproheptadine blockade of C-2 serotonin postsynaptic receptors. The immunomodulating effect of the neuropeptides studied is central one and is realized via the hypothalamus-hypophysis complex.
Cheĭdo
M A
MA
Idova
G V
GV
Pansuevich
O S
OS
D000276:Adjuvants, Immunologic / Q000494:pharmacology*; D000818:Animals; D001127:Arginine Vasopressin / Q000494:pharmacology; D003533:Cyproheptadine / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D004347:Drug Interactions; D006220:Haloperidol / Q000494:pharmacology; D007114:Immunization; D008236:Lypressin / Q000031:analogs & derivatives / Q000494:pharmacology; D008297:Male; D051379:Mice; D008808:Mice, Inbred CBA; D010446:Peptide Fragments / Q000494:pharmacology; D010902:Pituitary Gland / Q000187:drug effects / Q000276:immunology; D012397:Rosette Formation; D013154:Spleen / Q000187:drug effects / Q000276:immunology; D014667:Vasopressins / Q000494:pharmacology*
D000276:Adjuvants, Immunologic; D010446:Peptide Fragments; C079286:arginine vasopressin (2-5); D014667:Vasopressins; D001127:Arginine Vasopressin; D003533:Cyproheptadine; C000879:vasopressin, 9-des-Gly-NH(2)-Lys-; D008236:Lypressin; D006220:Haloperidol
Tsentral'nyĭ mekhanizm immunomoduliruiushchego deĭstviia vazopressina i ego strukturnykh analogov.