title: [Effects of crude extract of earthworm on promoting blood circulation to removing stasis].
abstract: The crude extract of earthworm which has a thrombolytic effect could significantly decrease the plasma fibrinogen content and euglobulin lysis time (P < 0.01). An enzymatic preparation, containing many fibrinolytic enzymes, was prepared from the crude extract by ammonium sulphate precipitation and DEAE-cellulose chromatography. When administered in rabbits, the enzymatic preparation had an effect in hemorheology improvement. The experiment shows the enzymatic preparation could obviously lower the aggregation of platelets, decrease the viscosity of whole blood and plasma as well as the index of erythrocyte rigidity significantly (P < 0.001). All these effects demonstrated its ability in promoting blood circulation to remove stasis.
authors.affiliation: Shanxi Medical College, Taiyuan.
authors.forename: Z X
authors.initials: ZX
authors.lastname: Zhang
authors.forename: F F
authors.initials: FF
authors.lastname: Wang
mesh_terms: D000818:Animals; D001775:Blood Circulation / Q000187:drug effects*; D001809:Blood Viscosity / Q000187:drug effects; D004907:Erythrocyte Deformability / Q000187:drug effects; D005260:Female; D005343:Fibrinolytic Agents / Q000494:pharmacology*; D008297:Male; D008419:Materia Medica / Q000494:pharmacology*; D009835:Oligochaeta; D010958:Plasminogen / Q000378:metabolism; D010974:Platelet Aggregation / Q000187:drug effects; D010975:Platelet Aggregation Inhibitors / Q000494:pharmacology; D011817:Rabbits
chemical_list: D005343:Fibrinolytic Agents; D008419:Materia Medica; D010975:Platelet Aggregation Inhibitors; D010958:Plasminogen