title: Sudden unexplained death syndrome. A review and update.
abstract: Sudden unexplained death syndrome (SUDS) among young healthy Thai construction workers in Singapore has been given much publicity recently. From May 1982 to July 1990, 226 SUDS were reported among them. In this article we review and compare studies on SUDS in the United States and South-east Asia. So far, studies to identify the causal factors have been inconclusive and they cannot explain the male preponderance and occurrence of death during sleep. Current hypotheses about the cause of SUDS have included stress, genetic factors, dietary deficiency (particularly thiamine), potassium deficiency, melioidosis and sleep disorders. The following areas are suggested for further research: epidemiological investigations on SUDS at its source; in-depth case studies of families with and without SUDS; role of dietary factors, biochemical studies with respect to thiamine, pyruvate and potassium metabolism in the victims and susceptibles; and histopathological studies of cases and controls.
authors.affiliation: Department of Community, Occupational and Family Medicine, National University of Singapore.
authors.forename: M L
authors.initials: ML
authors.lastname: Wong
authors.forename: C N
authors.initials: CN
authors.lastname: Ong
authors.forename: T C
authors.initials: TC
authors.lastname: Tan
authors.forename: K H
authors.initials: KH
authors.lastname: Phua
authors.forename: L G
authors.initials: LG
authors.lastname: Goh
authors.forename: K
authors.initials: K
authors.lastname: Koh
authors.forename: H P
authors.initials: HP
authors.lastname: Lee
authors.forename: S
authors.initials: S
authors.lastname: Chawalit
authors.forename: M
authors.initials: M
authors.lastname: Orapun
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D001210:Asia, Southeastern / Q000208:ethnology; D001344:Autopsy; D002423:Cause of Death; D003466:Cultural Characteristics; D003645:Death, Sudden / Q000453:epidemiology* / Q000209:etiology / Q000473:pathology; D005006:Ethnicity; D005260:Female; D006801:Humans; D015994:Incidence; D008297:Male; D008875:Middle Aged; D011159:Population Surveillance; D012036:Refugees; D012107:Research Design / Q000592:standards; D012307:Risk Factors; D012621:Seasons; D012737:Sex Factors; D012846:Singapore / Q000453:epidemiology; D012890:Sleep; D012959:Socioeconomic Factors; D013785:Thailand / Q000453:epidemiology; D014481:United States / Q000453:epidemiology