[Formation of left ventricular thrombus in acute myocardial infarction: significance of the determination of fibrinogen, of products of fibrinogen degradation, and of plasminogen].
OBJECTIVE
To evaluate the significance of the fibrinogen, the plasminogen and the fibrinogen degradation products levels as marks of left intraventricular thrombosis (LIVT) in acute myocardial infarction (AMI).


METHODS
219 consecutive patients of AMI admitted in a Coronary Care Unit of an University Hospital, were prospectively studied. All protocols included a clinical evaluation, an M-mode and 2D echocardiographic study and blood samples, at day 1, 3, 7 and at hospital discharge. In the intraventricular thrombus evaluation just the 4 Asinger grade was considered. In the laboratory evaluation we used: the Clauss chronometric method for the fibrinogen, the colorimetric method for the plasminogen and the agglutination in plaque for the FDP. The patients with ECO in the 2 or 3 Asinger grades and those in which ECO and laboratory study were not performed in the same day, were excluded. 101 patients remained on the study, and they were divided in two groups: 53 patients with LIVT and 48 patients without it.


RESULTS
In both groups the fibrinogen raised along the first six days of the AMI, however in the group with LIVT this level didn't raise as high as in the group without LIVT (p < 0.001). In the FDP evaluation two peaks were found, one at 48 hours and another on the 6 th day, but there were no differences between the two groups. The plasminogen values raised along the first week of AMI, in a similar way in both groups.


CONCLUSIONS
a) Fibrinogen levels raises in AMI, but this elevation is significantly smaller in the group with LIVT, which suggests fibrinogen consume in fibrin formation of the thrombus. b) FDP and plasminogen levels raise along the first week of AMI, but in a similar way in the two groups. c) None of these parameters permitted to individualize patients with thrombus formation.
Perdigão
C
C
UTIC-Arsénio Cordeiro, Hospital de Santa Maria, Lisboa.
Monteiro
J
J
Nunes
V
V
Varela
M G
MG
Geraldes
M J
MJ
Araújo
A
A
Pais
F
F
Ferreira
D
D
Ribeiro
C
C
D000368:Aged; D005260:Female; D005340:Fibrinogen / Q000032:analysis* / Q000378:metabolism; D006331:Heart Diseases / Q000097:blood* / Q000209:etiology; D006352:Heart Ventricles; D006801:Humans; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000150:complications*; D010958:Plasminogen / Q000032:analysis*; D011446:Prospective Studies; D013927:Thrombosis / Q000097:blood* / Q000209:etiology
D005340:Fibrinogen; D010958:Plasminogen
Formação de trombos intraventriculares esquerdos no enfarte agudo do miocárdio: significado das determinações do fribrinogénio, dos produtos de degradação do fibrinogénio e do plasminogénio.