title: Transmission of SIVMne from female to male Macaca nemestrina.
abstract: Three SIVMne-infected female pigtailed macaques (Macaca nemestrina) were mated with two SIV-negative males. The females exhibited signs of SAIDS and SIVMne was readily isolated from peripheral blood mononuclear cells (PBMC). Both males became infected with SIVMne, developed SAIDS, and died. This is the first documented case of the transmission of SIVMne between adult macaques housed together. Although transmission through scratching or biting cannot be ruled out, heterosexual transmission appears the most likely mode of SIVMne transmission in this study.
authors.affiliation: Regional Primate Research Center, University of Washington, Seattle 98195.
authors.forename: L
authors.initials: L
authors.lastname: Kuller
authors.forename: R E
authors.initials: RE
authors.lastname: Benveniste
authors.forename: R
authors.initials: R
authors.lastname: Watanabe
authors.forename: C C
authors.initials: CC
authors.lastname: Tsai
authors.forename: W R
authors.initials: WR
authors.lastname: Morton
mesh_terms: D000818:Animals; D002460:Cell Line; D004591:Electrophoresis, Polyacrylamide Gel; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D007963:Leukocytes, Mononuclear / Q000382:microbiology; D008254:Macaca nemestrina; D008297:Male; D008992:Monkey Diseases / Q000635:transmission*; D012726:Sexual Behavior, Animal; D015229:Sexually Transmitted Diseases, Viral / Q000635:transmission*; D016097:Simian Acquired Immunodeficiency Syndrome / Q000635:transmission*; D015302:Simian Immunodeficiency Virus / Q000302:isolation & purification