Effects of some tricyclic psychopharmacons and structurally related compounds on motility of Proteus vulgaris.
A simple test for the evaluation of drugs interfering with bacterial motility was established with Proteus vulgaris. With this model, promethazine, 7-hydroxy-chlorpromazine, imipramine, 7,8-dioxochlorpromazine and acridine orange were shown to exert significant motility and swarming inhibitory action on Proteus vulgaris strains at subinhibitory concentrations. Quinidine enhanced the antimotility effect of promethazine. The antimotility effect of promethazine was synergized by proton pump inhibitors omeprazole and abscissic acid, but antagonized by extracellular potassium and sodium ions.
Molnár
J
J
Institute of Microbiology, Albert Szent-Györgyi Medical University, Szeged, Hungary.
Ren
J
J
Kristiansen
J E
JE
Nakamura
M J
MJ
D000040:Abscisic Acid / Q000494:pharmacology; D002465:Cell Movement / Q000187:drug effects; D004357:Drug Synergism; D008826:Microbial Sensitivity Tests; D009853:Omeprazole / Q000494:pharmacology; D010640:Phenothiazines / Q000494:pharmacology*; D011188:Potassium / Q000494:pharmacology; D011514:Proteus vulgaris / Q000187:drug effects* / Q000502:physiology; D011802:Quinidine / Q000494:pharmacology*; D012964:Sodium / Q000494:pharmacology
D010640:Phenothiazines; D000040:Abscisic Acid; D012964:Sodium; D011802:Quinidine; D009853:Omeprazole; D011188:Potassium