The influence of endotracheal bleomycin administration on phospholipid composition of rat lung surfactant.
The influence of intratracheal bleomycin instillation (10 mg x kg-1) on lung surfactant phospholipids in rats after 7 and 14 days from drug administration was evaluated. It was stated that bleomycin causes a great fall in phosphatidylcholine, disaturated phosphatidylcholine and phosphatidylglycerol content, both in extra- and intracellular pool of surfactant. The data thus presented evidenced that intratracheal bleomycin administration caused a profound changes in the lipid composition of rat lung surfactant.
Ledwozyw
A
A
Department of Pathophysiology, Agricultural University, Lublin, Poland.
Ruciński
T
T
Synowiec
R
R
D000818:Animals; D001761:Bleomycin / Q000008:administration & dosage / Q000494:pharmacology*; D001992:Bronchoalveolar Lavage Fluid / Q000737:chemistry; D008297:Male; D010713:Phosphatidylcholines / Q000032:analysis; D010715:Phosphatidylglycerols / Q000032:analysis; D010743:Phospholipids / Q000032:analysis*; D010758:Phosphorus / Q000032:analysis; D011663:Pulmonary Surfactants / Q000737:chemistry / Q000187:drug effects*; D051381:Rats; D017207:Rats, Sprague-Dawley
D010713:Phosphatidylcholines; D010715:Phosphatidylglycerols; D010743:Phospholipids; D011663:Pulmonary Surfactants; D001761:Bleomycin; D010758:Phosphorus