Cholesterol-lowering in hamsters fed rice bran at various levels, defatted rice bran and rice bran oil.
This study was conducted to determine the relative cholesterol-lowering effects of several levels of full-fat rice bran in hamsters. In addition, the separate effects of defatted rice bran and/or crude rice bran oil were investigated at levels equivalent to those present in 43.7% full-fat rice bran. Diets containing 10.9, 21.8, 32.8 or 43.7% full-fat rice bran, 35% defatted rice bran and/or 9% rice bran oil were fed to 4-wk-old male hamsters. All diets contained 10% total dietary fiber, 9% fat and 3.2% nitrogen; hypercholesterolemic diets contained 0.3% cholesterol; two diets were cholesterol-free, i.e., 10% cellulose and 43.7% full-fat rice bran. After 21 d, plasma and liver cholesterol, plasma triglycerides and liver weights were significantly greater in hamsters fed the 10% cellulose diet with 0.3% cholesterol compared with those fed the cholesterol-free cellulose diet. In animals fed cholesterol-free diets, plasma cholesterol values were significantly lower in those fed the 43.7% full-fat rice bran diet than in those fed the cellulose diet. In animals fed cholesterol-containing diets, plasma and liver cholesterol were significantly lower in animals fed the 43.7% full-fat rice bran diet than in those fed the cellulose diet. Plasma cholesterol reductions were significantly correlated to the level of rice bran in the diet. In cholesterol-fed hamsters, total liver cholesterol content was significantly lower in those fed the defatted rice bran diet with rice bran oil compared with those fed the cellulose diet. Full-fat rice bran was the only treatment that significantly lowered both plasma and liver cholesterol.(ABSTRACT TRUNCATED AT 250 WORDS)
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Western Regional Research Center, USDA-Agricultural Research Service, Food Quality Research Unit, Albany, CA 94710.
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Sayre
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Betschart
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D000818:Animals; D001835:Body Weight; D002784:Cholesterol / Q000032:analysis* / Q000097:blood; D002791:Cholesterol, Dietary / Q000008:administration & dosage; D006224:Cricetinae; D004043:Dietary Fiber / Q000008:administration & dosage*; D004435:Eating; D008099:Liver / Q000033:anatomy & histology / Q000737:chemistry*; D008297:Male; D008647:Mesocricetus; D009929:Organ Size; D012275:Oryza; D010938:Plant Oils / Q000008:administration & dosage*; D011897:Random Allocation; D000073879:Rice Bran Oil; D014280:Triglycerides / Q000032:analysis / Q000097:blood
D002791:Cholesterol, Dietary; D004043:Dietary Fiber; D010938:Plant Oils; D014280:Triglycerides; D002784:Cholesterol; D000073879:Rice Bran Oil