title: DNA strand scissions by hydroxamic acids in the presence of Cu(II) ion under aerobic conditions.
abstract: Carbazolyloxyacetohydroxamic acid (1), 9,9'-decamethylene-bis-carbazolyloxyacetohydroxamic acid (2), benzohydroxamic acid (3), and acetohydroxamic acid (4) without reducing agent under aerobic conditions induced DNA strand scissions with increasing activities in the order of 4 > 3 > 2 > 1. The inhibition experiments indicated that hydrogen peroxide and superoxide participated in the reactions, but hydroxyl radical or singlet oxygen did not.
authors.affiliation: Department of Biological Science and Technology, Science University of Tokyo, Chiba, Japan.
authors.forename: S
authors.initials: S
authors.lastname: Hashimoto
authors.forename: Y
authors.initials: Y
authors.lastname: Nakamura
mesh_terms: D000818:Animals; D002417:Cattle; D003300:Copper / Q000494:pharmacology*; D004247:DNA / Q000187:drug effects*; D006868:Hydrolysis; D006877:Hydroxamic Acids / Q000494:pharmacology*; D010100:Oxygen / Q000494:pharmacology
chemical_list: D006877:Hydroxamic Acids; D003300:Copper; D004247:DNA; D010100:Oxygen