Modulation of adenylate cyclase signalling.
Adenylate cyclase via production of cyclic AMP (cAMP) can transduce dual signals, positive and negative, on cell growth and differentiation. Such dual signals are transmitted by RI and RII cAMP-binding receptor proteins respectively, the regulatory subunits of cAMP dependent protein kinases. The growth stimulatory RI and inhibitory RII are in a strict balance to maintain normal cells, and departure from such balance can cause a great variety of human diseases, including cancer. Experimental approaches using site-selective cAMP analogues, antisense oligodeoxynucleotides, and gene transfer have shown that restoration of the normal balance of RI/RII provides a biological means to the suppression of malignancy.
Cho-Chung
Y S
YS
Laboratory of Tumor Immunology and Biology, National Cancer Institute, Bethesda, MD 20892.
D000262:Adenylyl Cyclases / Q000187:drug effects* / Q000502:physiology; D000970:Antineoplastic Agents / Q000494:pharmacology*; D006801:Humans; D015398:Signal Transduction / Q000187:drug effects*
D000970:Antineoplastic Agents; D000262:Adenylyl Cyclases