title: Testicular adrenal-like tissue in a patient with 17 alpha-hydroxylase deficiency.
abstract: Testicular adrenal-like tissue (TALT) have been observed in patients with congenital adrenal hyperplasia, and is usually associated with 21-hydroxylase deficiency; in 3 cases with 11 beta-hydroxylase deficiency. We report a case of male pseudohermaphroditism with 17 alpha-hydroxylase deficiency (17OHD) who also had TALT. To our knowledge, this is the first report about the association of 17OHD and TALT. Also, the patient had high levels of serum aldosterone--an unusual finding in patients with 17OHD. A possible pathogenic mechanism is discussed.
authors.affiliation: Endocrine Section, General Hospital of Vigo, Galicia, Spain.
authors.forename: R V
authors.initials: RV
authors.lastname: García-Mayor
authors.forename: B
authors.initials: B
authors.lastname: Sopeña
authors.forename: E
authors.initials: E
authors.lastname: Fluiters
authors.forename: C
authors.initials: C
authors.lastname: Páramo
authors.forename: R
authors.initials: R
authors.lastname: Fernández Martín
authors.forename: J C
authors.initials: JC
authors.lastname: Galofré
authors.forename: A
authors.initials: A
authors.lastname: Andrade Olivié
mesh_terms: D000293:Adolescent; D000311:Adrenal Glands / Q000473:pathology*; D000312:Adrenal Hyperplasia, Congenital / Q000150:complications / Q000378:metabolism / Q000473:pathology; D000450:Aldosterone / Q000097:blood; D012734:Disorders of Sex Development / Q000150:complications* / Q000378:metabolism; D006728:Hormones / Q000097:blood; D006801:Humans; D008297:Male; D010641:Phenotype; D013736:Testicular Neoplasms / Q000150:complications* / Q000378:metabolism / Q000473:pathology
chemical_list: D006728:Hormones; D000450:Aldosterone