[Lipid peroxidation and antioxidant enzymatic defense in patients with newly detected insulin-dependent diabetes mellitus].
Studies of lipid peroxidation and antioxidant enzymic defense in red cell membranes in 23 patients with newly detected insulin-dependent diabetes mellitus have revealed a statistically significant (2-fold) elevation of malonic dialdehyde lipid peroxidation products and a trend to a rise in the levels of lipid peroxides. This is parallelled by a certain overstrain of the cellular antioxidant defense system. The authors discuss the usefulness of administering antioxidant therapy at the onset of the disease in order to prevent the toxic injury of beta-cells and vascular endothelium cells by lipid peroxidation products.
Dedov
I I
II
Gorel'sheva
V A
VA
Romanovskaia
G A
GA
Smirnova
O M
OM
Filippov
I K
IK
Sanfirova
V M
VM
D000293:Adolescent; D000328:Adult; D003922:Diabetes Mellitus, Type 1 / Q000097:blood* / Q000201:enzymology; D004910:Erythrocyte Membrane / Q000378:metabolism; D005979:Glutathione Peroxidase / Q000097:blood; D006801:Humans; D015227:Lipid Peroxidation; D008054:Lipid Peroxides / Q000097:blood; D008315:Malondialdehyde / Q000097:blood; D010084:Oxidation-Reduction; D013482:Superoxide Dismutase / Q000097:blood
D008054:Lipid Peroxides; D008315:Malondialdehyde; D005979:Glutathione Peroxidase; D013482:Superoxide Dismutase
Perekisnoe okislenie lipidov i antioksidantnaia fermentativnaia zashchita u bol'nykh s vpervye vyiavlennym insulinzavisimym sakharnym diabetom.