Studies concerning the effect of Ukrain in vivo and in vitro.
Ukrain, a reaction product of different alkaloids of Chelidonium majus L. (celandine) with Thio tepa has been investigated for possible use as an anticancer agent. A possible tumour inhibiting effect on the Ehrlich mouse ascites tumour is now tested in vivo. Moreover, possible changes in the oxygen consumption of mouse ascites tumour cells and a guinea pig liver homogenate are to be determined after the administration of Ukrain in vitro with the aid of an oxygen electrode.
Brüller
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Bundesstaatliche Anstalt für Experimentall-Pharmakologische und Balneologische Untersuchungen, Vienna, Austria.
D000470:Alkaloids / Q000494:pharmacology*; D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000494:pharmacology*; D001600:Berberine Alkaloids; D002286:Carcinoma, Ehrlich Tumor / Q000378:metabolism; D004566:Electrodes; D006168:Guinea Pigs; D066298:In Vitro Techniques; D008297:Male; D051379:Mice; D008862:Microsomes, Liver / Q000187:drug effects / Q000378:metabolism; D010101:Oxygen Consumption / Q000187:drug effects; D010617:Phenanthridines
D000470:Alkaloids; D000972:Antineoplastic Agents, Phytogenic; D001600:Berberine Alkaloids; D010617:Phenanthridines; C060921:ukrain