DNA strand scissions by hydroxamic acids in the presence of Cu(II) ion under aerobic conditions.
Carbazolyloxyacetohydroxamic acid (1), 9,9'-decamethylene-bis-carbazolyloxyacetohydroxamic acid (2), benzohydroxamic acid (3), and acetohydroxamic acid (4) without reducing agent under aerobic conditions induced DNA strand scissions with increasing activities in the order of 4 > 3 > 2 > 1. The inhibition experiments indicated that hydrogen peroxide and superoxide participated in the reactions, but hydroxyl radical or singlet oxygen did not.
Hashimoto
S
S
Department of Biological Science and Technology, Science University of Tokyo, Chiba, Japan.
Nakamura
Y
Y
D000818:Animals; D002417:Cattle; D003300:Copper / Q000494:pharmacology*; D004247:DNA / Q000187:drug effects*; D006868:Hydrolysis; D006877:Hydroxamic Acids / Q000494:pharmacology*; D010100:Oxygen / Q000494:pharmacology
D006877:Hydroxamic Acids; D003300:Copper; D004247:DNA; D010100:Oxygen