Full-blown hypothyroidism associated with vitiligo and acropachy. Report of one case.
During the first two years after the onset of hypothyroidism, a patient with spontaneous primary myxedema developed thyroid acropachy. Fifteen years before the diagnosis of thyroid disease, he had patchy vitiligo of the face. There were high serum levels of antibodies against thyroglobulin (anti-Tg) and microsomal antigen (anti-M) were present, while the serum levels of antibodies against the second antigen of the colloid and the cell-surface antigen fell within the normal range. Moreover, antibodies to gastric parietal cells, adrenocortical cells or pancreatic islets in the serum were not present. Concerning the immuno-genetic pattern of our patient, his HLA system did not appear to confirm the well documented prevalence in whites with autoimmune disorders of an antigen specificity positive for the locus DR3.
Curti
L G
LG
Department of Nuclear Medicine University of Genoa, School of Medicine, Italy.
Siccardi
M
M
Santianello
E B
EB
Fresco
G
G
D000906:Antibodies / Q000032:analysis; D006680:HLA Antigens / Q000032:analysis; D006801:Humans; D007037:Hypothyroidism / Q000150:complications*; D008297:Male; D008875:Middle Aged; D009230:Myxedema / Q000209:etiology; D010005:Osteoarthropathy, Secondary Hypertrophic / Q000209:etiology*; D013960:Thyroid Function Tests; D013963:Thyroid Hormones / Q000276:immunology; D014820:Vitiligo / Q000209:etiology*
D000906:Antibodies; D006680:HLA Antigens; D013963:Thyroid Hormones