[Morphologic placenta findings in clinico-serologically verified and suspected rubella infection in the 2d half of pregnancy].
Rubeola is the congenital infection with the highest rate of embryonal damage. The hematogenous transplacental way of infection also causes morphological changes at the vessels of the placental villi. We examined 38 placentas from up to the 44th week of gestation and the fetus and children belonging to them. We regarded the clinical and serological findings. 6 out of 16 placentas from up to the 18th week of gestation (37.5%) showed endangitis obliterans. Two cases showed changes of the lenses. (Group I). In 10 out of 12 cases from the 19th to the 36th week of gestation (Group II) we found morphological changes in the vessels of the placental villi. The children belonging to them showed nonspecific malformations. From the 37th week of gestation (Group III) half of the placentas was histologically conspicuous. The children did not show malformations specific for rubeola. We refer to the possibilities and limitations of performing light microscopic diagnosis in placenta when there is the suspicion of rubeola infection, intrauterine death of the fetus and postnatal delay of the child's development.
Horn
L C
LC
Institut für Pathologische Anatomie, Universität Leipzig.
Becker
V
V
D000914:Antibodies, Viral / Q000032:analysis; D002824:Chorionic Villi / Q000098:blood supply / Q000473:pathology; D004692:Endarteritis / Q000276:immunology / Q000473:pathology; D005260:Female; D005313:Fetal Death / Q000473:pathology; D006801:Humans; D007075:Immunoglobulin M / Q000032:analysis; D007231:Infant, Newborn; D009131:Muscle, Smooth, Vascular / Q000473:pathology; D010920:Placenta / Q000098:blood supply / Q000276:immunology / Q000473:pathology*; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000276:immunology / Q000473:pathology*; D011262:Pregnancy Trimester, Second; D011263:Pregnancy Trimester, Third; D012409:Rubella / Q000276:immunology / Q000473:pathology*; D012410:Rubella Syndrome, Congenital / Q000276:immunology / Q000473:pathology*
D000914:Antibodies, Viral; D007075:Immunoglobulin M; C040901:rubella antibodies
Morphologische Plazentabefunde bei klinisch-serologisch gesicherter und vermuteter Rötelninfektion in der zweiten Schwangerschaftshälfte.