A new method for the creation and measurement of experimental craniosynostosis.
Craniosynostosis is described as a condition in which the premature closure of one or more cranial sutures is exposed as a skull deformity alone or accompanied by neurological disturbances. According to previous research it seemed possible to create an experimental model for investigating the disease by simply resecting a suture in a newborn rabbit. We resected 16 coronal sutures in 16 newborn rabbits and had the skulls investigated for shape and histology up to 6 months of age. A clear deformity at the cranial vault could be detected. The fused site of the suturectomy later on presented a suture-like structure which was macroscopically distinct from a normal skull suture. The procedure is thus established, first, for investigating procedures for treating craniosynostosis in the growing skull, and, secondly, for studying the pathophysiology of craniosynostosis.
Antikainen
T
T
Department of Surgery, Oulu University Central Hospital, Finland.
Kallioinen
M
M
Waris
T
T
Serlo
W
W
D000818:Animals; D003398:Craniosynostoses / Q000473:pathology / Q000601:surgery*; D004195:Disease Models, Animal; D011817:Rabbits; D012886:Skull / Q000473:pathology; D013536:Suture Techniques