Indomethacin and fertility in experimental endometriosis.
Clinical and experimental evidence showed an increased concentration of prostaglandins in peritoneal fluid in cases of endometriosis. The aim of this study was to verify whether an antiprostaglandin drug can restore fertility in cases of endometriosis. For this reason endometriosis was induced in 4 groups of 10 rats. Group A was treated with indomethacin both in the pre-ovulatory and in the post-ovulatory phase. Group B was treated in the pre-ovulatory phase. Group C was treated in the post-ovulatory phase. Group D was not treated. Ten other rats (group E) underwent a sham operation and were used as a control. Twelve days after mating, gestational sacs and corpora lutea were counted and the nidation index was calculated. Only indomethacin administered during the pre-ovulatory phase completely restored fertility in these rats.
Dargenio
R
R
Department of Obstetrics and Gynecology, Università Cattolica del Sarco Cuore, Rome, Italy.
Corbucci
M G
MG
Lamanna
M A
MA
Garcea
N
N
D000818:Animals; D004195:Disease Models, Animal; D004334:Drug Administration Schedule; D004715:Endometriosis / Q000150:complications*; D005260:Female; D007213:Indomethacin / Q000008:administration & dosage / Q000627:therapeutic use*; D007247:Infertility, Female / Q000188:drug therapy* / Q000209:etiology; D007273:Injections, Intramuscular; D010534:Peritoneal Neoplasms / Q000150:complications*; D011247:Pregnancy; D011453:Prostaglandins / Q000502:physiology; D051381:Rats; D017208:Rats, Wistar
D011453:Prostaglandins; D007213:Indomethacin