[Preclinical trials of polyplatillen, the antitumor activity of a complex platinum compound with DNA on a leukemia P388 model in a HEp-2 cell culture (1)].
The authors studied the antitumour activity of a new complex platinum compound (DDP-DNA) in mice with leukemia P-388 and in cell culture. DDP-DNA was introduced intraperitoneally 24 hours after inoculation of 2 x 10(6) tumour cells. It was established that by its antitumour activity DDP-DNA was not inferior then DDP. The antiproliferative activity of nontoxic doses of the preparation in cell culture has been shown.
Shalimov
S A
SA
Trokhimenko
E P
EP
Dziublik
I V
IV
Keĭsevich
L V
LV
Volchenskova
I I
II
Kogut
G I
GI
Glukhen'kaia
G T
GT
D000818:Animals; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D002945:Cisplatin / Q000627:therapeutic use*; D004247:DNA / Q000627:therapeutic use*; D018736:DNA Adducts; D004305:Dose-Response Relationship, Drug; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D007941:Leukemia P388 / Q000188:drug therapy*; D051379:Mice; D008811:Mice, Inbred DBA; D009368:Neoplasm Transplantation; D013997:Time Factors; D014407:Tumor Cells, Cultured / Q000187:drug effects
D000970:Antineoplastic Agents; D018736:DNA Adducts; C057270:cisplatin-DNA adduct; D004247:DNA; D002945:Cisplatin
Doklinicheskie ispytaniia poliplatillena, protivoopukholevaia aktivnost' kompleksnogo soedineniia platiny s DNK na modeli leĭkemii P-388 v kul'ture kletok HEp-2 (soobshchenie 1).