[Are metoclopramide dystonias familial?].
Metoclopramide is an antiemetic drug; the effects on CNS (acute dystonic reaction, tardive dyskinesia, parkinsonism) occur in only 1 of 500 patients treated. Acute dystonic reactions are not apparently dose-dependent and suggest individual sensitivity to the drug (idiosyncrasia). We report 4 cases in 2 families (grandmother-grandchild; brother-sister). We feel that, if there is a case of dystonic reaction to metoclopramide, this drug should not be administered to other members of the same family.
Guala
A
A
Divisione di Pediatria, Ospedale di Borgosesia VC, Italia.
Mittino
D
D
Ghini
T
T
Quazza
G
G
D000293:Adolescent; D002648:Child; D004421:Dystonia / Q000139:chemically induced* / Q000235:genetics*; D005260:Female; D006801:Humans; D008297:Male; D008787:Metoclopramide / Q000009:adverse effects*; D008875:Middle Aged
D008787:Metoclopramide
Le distonie da metoclopramide sono familiari?