Luteinizing hormone pulses, follicle-stimulating hormone and control of follicle selection in sheep.
The growth of large oestrogenic follicles that have the potential to ovulate if given an appropriate luteinizing hormone (LH) signal is dictated by the plasma concentration of follicle-stimulating hormone (FSH). Basal amounts of LH are essential for this FSH-induced follicle growth, but pulses of LH do not appear to be essential. The fall in FSH concentration during the follicular phase of the oestrous cycle in sheep, and the subsequent withdrawal of FSH from other developing follicles may not be sufficient to explain follicle selection. There is little evidence to support an active suppression of the growth of other follicles by a factor(s) produced by the dominant, or selected follicle. It is possible that LH pulses cause active atresia of non-selected follicles. The selected follicle is the one that can survive the fall in plasma FSH and the large increase in LH pulses during the follicular phase and selection may simply be a case of being the follicle(s) that is present at the correct time to receive adequate FSH and develop sufficiently to survive the inhibitory effects of LH pulses. Several mechanisms whereby LH pulses may inhibit follicle growth are suggested, and avenues for future research, particularly related to the expression of the LH receptor on granulosa cells of the developing follicle, are outlined.
McNeilly
A S
AS
MRC Reproductive Bioloy Unit, University of Edinburgh, UK.
Crow
W
W
Brooks
J
J
Evans
G
G
D000818:Animals; D004958:Estradiol / Q000097:blood; D005260:Female; D005640:Follicle Stimulating Hormone / Q000502:physiology*; D005498:Follicular Phase / Q000502:physiology; D007986:Luteinizing Hormone / Q000502:physiology*; D006080:Ovarian Follicle / Q000502:physiology*; D010060:Ovulation; D011374:Progesterone / Q000097:blood; D011974:Receptors, LH / Q000378:metabolism; D012756:Sheep; D013997:Time Factors
D011974:Receptors, LH; D011374:Progesterone; D004958:Estradiol; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone