[The effect of the treatment of skin wounds in rats with hydrolytic enzymes on the synthetic activity of the epidermocytes].
Epidermis cells synthetic activity was studied by a luminescent microscopy method. Different conditions of skin wound healing in intrascapular region were investigated on 84 rats-males. Daily effect of 0.2% trypsin or 0.1% ronidase solution on the healing surface for 20 min has been shown to increase basal layer cells synthetic activity of forming epidermis in comparison with control. However, maximum raise of epidermis cells functional activity after ronidase influence was observed already on the 4th day, while after trypsin action--only on the 7th. Epithelial cells synthetic activity decreases several days before total skin defect epithelialization. In all experiments their activity stabilizes not less than one month after the operation. We have come to a conclusion that the mechanism of healing acceleration due to proteolytic enzymes depends on basal layer cells synthetic activity of forming epithelium.
Ershova
T V
TV
Ivanishchuk
P P
PP
Dindiaev
S V
SV
D000818:Animals; D004353:Drug Evaluation, Preclinical; D000078404:Epidermal Cells; D004817:Epidermis / Q000187:drug effects* / Q000378:metabolism; D006596:Hexosaminidases / Q000627:therapeutic use*; D008297:Male; D051381:Rats; D012867:Skin / Q000293:injuries*; D012996:Solutions; D013997:Time Factors; D014357:Trypsin / Q000627:therapeutic use*; D014945:Wound Healing / Q000187:drug effects / Q000502:physiology
D012996:Solutions; D006596:Hexosaminidases; C019080:ronidase; D014357:Trypsin
Vliianie obrabotki kozhnykh ran u krys gidroliticheskimi fermentami na sinteticheskuiu aktivnost' épidermotsitov.