[Mechanisms of cellular detoxication, nuclear aluminum concentration and hepatocyte protection after experimental overload in rats].
A single injection of a massive dose of Al-gluconate (4 mg.kg-1) into the saphenous vein of the rat did not provoke any ultrastructural damage in the liver cells, from 2 min. to 8 days after the injection. Al hepatocytes overload appeared only in nuclei and not in nuclei and not in lysosomes, contrarily to chronic intoxications. Nuclear Al concentration concerned only a small fraction of the quantity injected; another part was sequestered by the macrophage system after precipitation in the blood as phosphates chemically transformed during their incorporation in lysosomes. This effective detoxication mechanism which functioned probably after a first absorption by the hepatocyte, was likely to depend upon the form of gluconate and would explain the resistance of liver cells.
Jeantet
A Y
AY
Laboratoire d'Histophysiologie fondamentale et appliquée, Université Paris-VI.
Ballan-Dufrançais
C
C
Petter
C
C
Truchet
M
M
D000535:Aluminum / Q000008:administration & dosage / Q000493:pharmacokinetics*; D000818:Animals; D002467:Cell Nucleus / Q000378:metabolism*; D008658:Inactivation, Metabolic; D008099:Liver / Q000166:cytology* / Q000378:metabolism*; D008297:Male; D051381:Rats; D017208:Rats, Wistar
D000535:Aluminum
Mécanismes de détoxication cellulaire, concentration nucléaire d'aluminium et protection de l'hépatocyte après surcharge expérimentale chez le rat.