title: Breast cancer: reliability of mammographic appearance as a predictor of hormone receptor status.
abstract: The association of mammographic appearance with hormone receptor status was investigated in 397 patients with primary breast cancers. The mammographic appearance was classified as type 1, spiculated (n = 159); type 2, structural changes (density) (n = 102); type 3, calcifications (n = 30); type 4, circumscribed opacity (n = 65); and type 5, not visible on mammogram (n = 41). Univariate analysis showed a significant association with estrogen receptor (ER) status for age (less than 50 vs greater than or equal to 50 years), tumor TNM category (those in category 1 vs those in higher categories), and mammographic appearance; with progesterone receptor status, the association was significant only for age. Multivariate analysis adjusted for potential confounders confirmed a significant association between ER status and mammographic appearance (ER status was more likely with type 1 than with the other mammographic types), but the strength of the association was limited. The mammographic appearance of breast cancer is not a reliable method to predict hormone receptor status for clinical purposes.
authors.affiliation: Centro per lo Studio e la Prevenzione, Oncologica, Florence, Italy.
authors.forename: S
authors.initials: S
authors.lastname: Ciatto
authors.forename: D
authors.initials: D
authors.lastname: Morrone
authors.forename: S
authors.initials: S
authors.lastname: Catarzi
authors.forename: R
authors.initials: R
authors.lastname: Bonardi
mesh_terms: D001940:Breast / Q000737:chemistry*; D001943:Breast Neoplasms / Q000737:chemistry* / Q000000981:diagnostic imaging* / Q000453:epidemiology; D002277:Carcinoma / Q000737:chemistry / Q000000981:diagnostic imaging / Q000453:epidemiology; D002285:Carcinoma, Intraductal, Noninfiltrating / Q000737:chemistry* / Q000000981:diagnostic imaging* / Q000453:epidemiology; D005260:Female; D006801:Humans; D008327:Mammography; D008875:Middle Aged; D015999:Multivariate Analysis; D011237:Predictive Value of Tests; D011960:Receptors, Estrogen / Q000032:analysis*; D011980:Receptors, Progesterone / Q000032:analysis*
chemical_list: D011960:Receptors, Estrogen; D011980:Receptors, Progesterone