[The immunohistochemical study of trophoblast beta 1-globulin expression in cancer and in the mucosa of the large intestine].
The expression of pregnancy-specific beta-1-globulin (SP1) was studied in cancer-affected and nonaffected colon mucosa. The antigen was revealed in 19 out of 50 (38%) cases of carcinoma and in 1 out of 4 cases of ulcerative colitis. SP1 was found neither in noncancer colon mucosa nor in transitional mucosa and adenomas. The antigen was detected in the epithelium and stromal macrophages of carcinoma. SP1-positive cells were located mainly in the sites of tumor invasion. The results allow considering SP1 the tumor marker suitable for immunohistochemical diagnosis of colon cancer.
Pugachev
K K
KK
Shimbireva
I B
IB
Belous
T A
TA
Frank
G A
GA
D000230:Adenocarcinoma / Q000175:diagnosis*; D000328:Adult; D014408:Biomarkers, Tumor / Q000378:metabolism*; D003093:Colitis, Ulcerative / Q000175:diagnosis; D003106:Colon / Q000378:metabolism*; D003110:Colonic Neoplasms / Q000175:diagnosis*; D006801:Humans; D007150:Immunohistochemistry; D007413:Intestinal Mucosa / Q000378:metabolism*; D008207:Lymphatic Metastasis; D011257:Pregnancy Proteins / Q000378:metabolism*; D011268:Pregnancy-Specific beta 1-Glycoproteins / Q000378:metabolism*
D014408:Biomarkers, Tumor; D011257:Pregnancy Proteins; D011268:Pregnancy-Specific beta 1-Glycoproteins
Immunogistokhimicheskoe izuchenie ékspressii trofoblasticheskogo beta-1-globulina v rake i slizistoĭ obolochke tolstoĭ kishki.