title: Acquired chronic pure red cell aplasia successfully treated with intravenous pulse methylprednisolone therapy.
abstract: A 65-year-old male patient developed acquired chronic pure red cell aplasia (PRCA) associated with hypergammaglobulinemia and positive Coombs' test during the treatment of eosinophilic pneumonia with prednisolone (PSL). His PRCA was treated with oral PSL at a dose of 60 mg/day for 3 weeks, but anemia further progressed. Immediately after high-dose intravenous pulse methylprednisolone therapy (1 g/day for 3 days) however, reticulocyte crisis occurred and his anemia rapidly improved. He has been in complete remission under a maintenance dose of PSL for more than 2 years. This patient indicates that high-dose intravenous methylprednisolone therapy is one of the useful treatments, not only for constitutional PRCA, but also for acquired chronic PRCA.
authors.affiliation: Department of Internal Medicine, Tokai University School of Medicine, Isehara, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Uchiyama
authors.forename: Y
authors.initials: Y
authors.lastname: Ichikawa
authors.forename: M
authors.initials: M
authors.lastname: Komatsuda
authors.forename: A
authors.initials: A
authors.lastname: Miyairi
authors.forename: S
authors.initials: S
authors.lastname: Arimori
mesh_terms: D000368:Aged; D002908:Chronic Disease; D003298:Coombs Test; D006801:Humans; D006942:Hypergammaglobulinemia / Q000150:complications; D007275:Injections, Intravenous; D008297:Male; D008775:Methylprednisolone / Q000008:administration & dosage*; D011657:Pulmonary Eosinophilia / Q000150:complications; D012010:Red-Cell Aplasia, Pure / Q000097:blood / Q000150:complications / Q000188:drug therapy*
chemical_list: D008775:Methylprednisolone