Effect of cyclosporin-A treatment on microsomal enzyme activities in rat liver.
The effect of orally administered fixed dose cyclosporin-A (CsA) on rat liver monooxygenase activities was studied. Group I was treated for 3, group II for 7 and group III for 17 consecutive days. A time dependence in the degree of inhibition and number of microsomal enzyme activities inhibited was observed.
Szabó
I
I
Apáthy István Children's Hospital, Budapest, Hungary.
Renczes
G
G
Balló
M
M
D000818:Animals; D016572:Cyclosporine / Q000494:pharmacology*; D066298:In Vitro Techniques; D008297:Male; D008862:Microsomes, Liver / Q000187:drug effects / Q000201:enzymology*; D006899:Mixed Function Oxygenases / Q000037:antagonists & inhibitors* / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar
D016572:Cyclosporine; D006899:Mixed Function Oxygenases