Effects of toluene on the morphology of neuropeptide secretory neurons of the rat hypothalamus.
The effect of toluene on the hypothalamic hormone-secreting neurons and neurotransmitter-containing fibers in the rat was investigated by immunohistochemical methods. Multiple intraperitoneal injections of toluene (totally 7.5 ml) led to significant decreases of the neuronal numbers of vasopressin, oxytocin and neuropeptide Y in the preoptic and hypothalamic areas. The densities of vasopressin, oxytocin, norepinephrine and neuropeptide Y immunoreactive fibers of the toluene dose group decreased markedly in the median eminence. In contrast, LHRH neurons remained unchanged.
Shen
C L
CL
Department of Anatomy, College of Medicine, National Cheng Kung University, Tainan, Taiwan, Republic of China.
Ting
W H
WH
Chang
T K
TK
D000818:Animals; D002452:Cell Count; D005260:Female; D007987:Gonadotropin-Releasing Hormone / Q000032:analysis; D007030:Hypothalamo-Hypophyseal System / Q000187:drug effects; D007031:Hypothalamus / Q000166:cytology / Q000187:drug effects*; D009474:Neurons / Q000737:chemistry / Q000187:drug effects* / Q000648:ultrastructure; D009478:Neuropeptide Y / Q000032:analysis*; D009638:Norepinephrine / Q000032:analysis*; D010121:Oxytocin / Q000032:analysis*; D011301:Preoptic Area / Q000166:cytology / Q000187:drug effects*; D051381:Rats; D017208:Rats, Wistar; D014050:Toluene / Q000494:pharmacology* / Q000633:toxicity; D014667:Vasopressins / Q000032:analysis*
D009478:Neuropeptide Y; D014667:Vasopressins; D007987:Gonadotropin-Releasing Hormone; D014050:Toluene; D010121:Oxytocin; D009638:Norepinephrine