[Dynamic changes in the platelet granule membrane glycoprotein level in patients with acute myocardial infarction].
Platelet granule membrane glycoprotein (GMP-140) level was measured by using 125I labelled monoclonal antibody (SZ-51) in 20 patients with acute myocardial infarction in the first three days and at the first three weekends. The correlation of severe arrhythmia and administration of aspirin with platelet GMP-140 in AMI were studied respectively. It is shown that platelet GMP-140 increased significantly in the first three days after AMI, then it dropped quickly, but remained at high level as compared with the controlled group till the third weekend (P < 0.01). Platelet GMP-140 level was higher in the first three days than at the first three weekends (P < 0.01). The changes of platelet GMP-140 have not been shown to be related with severe arrhythmia or administration of aspirin (P > 0.05). The results indicated that the platelets in AMI are activated continuously in the first three weeks after infarction; it might be thought as an important index of coronary artery thrombus formation.
Li
W G
WG
Beijing Red Cross Chao Yang Hospital.
Chui
Z C
ZC
Zhoa
Y J
YJ
D000368:Aged; D001241:Aspirin / Q000627:therapeutic use*; D005260:Female; D006327:Heart Block / Q000097:blood / Q000209:etiology; D006801:Humans; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000097:blood* / Q000150:complications; D010980:Platelet Membrane Glycoproteins / Q000378:metabolism*; D017180:Tachycardia, Ventricular / Q000097:blood / Q000209:etiology
D010980:Platelet Membrane Glycoproteins; D001241:Aspirin