[Recurrent peptic ulcer after gastric surgery].
Recurrent peptic ulcer after gastric surgery differs from duodenal ulcer in that they usually occur with low acid output, which is sufficient to cause ulceration in predisposed stomach or anastomosis. The proton pump inhibitor (PPI), significantly more potent and long-acting than H2-blocker, is expected to be more effective for postoperative recurrent ulcers. We evaluated the efficacy of omeprazole (OPZ) on recurrent ulcers in 12 patients following either gastrectomy or vagotomy. The healing rate after 4 week treatment with OPZ was 58% and increased to 100% after 8 week. Evaluation of quick symptom relief also supported the efficacy of OPZ treatment. These findings showed that OPZ treatment resulted in a more rapid healing of recurrent ulcers compared with H2-blocker. It remains to be clarified whether quit of treatment with PPI would induce high ulcer relapse rates, and whether maintenance therapy with PPI would be the only alternative therapy for surgical intervention.
Sugiyama
M
M
Dept. of Critical Care and Emergency Medicine, Yokohama.
Katamura
H
H
D000251:Adenosine Triphosphatases / Q000037:antagonists & inhibitors*; D000328:Adult; D000368:Aged; D005260:Female; D005743:Gastrectomy; D005744:Gastric Acid / Q000378:metabolism; D005755:Gastrins / Q000097:blood; D017506:H(+)-K(+)-Exchanging ATPase; D006801:Humans; D008297:Male; D008875:Middle Aged; D009853:Omeprazole / Q000627:therapeutic use*; D010437:Peptic Ulcer / Q000188:drug therapy* / Q000503:physiopathology / Q000601:surgery; D011183:Postoperative Complications / Q000188:drug therapy* / Q000503:physiopathology; D012008:Recurrence; D014628:Vagotomy
D005755:Gastrins; D000251:Adenosine Triphosphatases; D017506:H(+)-K(+)-Exchanging ATPase; D009853:Omeprazole