[The energy metabolism of the liver under the action on the body of different durations of hypokinesia].
Studies of tissue respiration and oxidative phosphorylation of homogenates in the liver of white rats indicated that the 3-day hypokinesia is associated with a decreased rate of endogenic respiration and an increased amythal-resistant respiration. On the 10th day, there occurs a sharp increase of the oxidation rate of the endo- and exogenic substrates and the separation of oxidative phosphorylation takes place. During 30-day immobilization, the homogenate respiratory activity again decreases while on the 70-140th days of an exposure the oxidation rate of endo- and exogenic substrates increases with an increased effect of endogenic succinate on the hepatocyte energy metabolism. The possible mechanism disturbances in the liver of immobilized animals are discussed.
Gritsiuk
A I
AI
Danilova
I G
IG
Segal'
N K
NK
D000818:Animals; D004734:Energy Metabolism / Q000502:physiology*; D007103:Immobilization / Q000502:physiology*; D008099:Liver / Q000378:metabolism*; D008297:Male; D010085:Oxidative Phosphorylation; D010101:Oxygen Consumption; D051381:Rats; D012149:Restraint, Physical; D013997:Time Factors
Energeticheskiĭ obmen v pecheni pri deĭstvii na organizm gipokinezii razlichnoĭ prodolzhitel'nosti.