[The immunomodulating action of riboxin during physical loading].
Administration of riboxin to Wistar rats which had no exercise increased the development of a humoral immune response, but failed to affect the manifestations of delayed hypersensitivity induced by sheep red cells. Riboxin given to swimming rats intensified the development of two immune response types. The agent enhanced splenic cell release of suppressive and helper agents in swimming rats and reduced the responsiveness of the immune system to suppressive agents liberated by splenocytes during exercise. The cells of the swimming rats' immune system were sensitive to the helper agent liberated by splenocytes after riboxin administration.
Laskova
I L
IL
Uteshev
B S
BS
D000276:Adjuvants, Immunologic / Q000494:pharmacology*; D000818:Animals; D000917:Antibody Formation / Q000187:drug effects; D000921:Antibody-Producing Cells / Q000187:drug effects / Q000276:immunology; D004305:Dose-Response Relationship, Drug; D006968:Hypersensitivity, Delayed / Q000276:immunology; D007114:Immunization; D007290:Inosine Diphosphate / Q000494:pharmacology*; D005082:Physical Exertion / Q000187:drug effects* / Q000502:physiology; D051381:Rats; D017208:Rats, Wistar; D013154:Spleen / Q000187:drug effects / Q000276:immunology; D013550:Swimming; D006377:T-Lymphocytes, Helper-Inducer / Q000187:drug effects / Q000276:immunology
D000276:Adjuvants, Immunologic; D007290:Inosine Diphosphate
Immunomoduliruiushchee deĭstvie riboksina pri fizicheskoĭ nagruzke.