Indomethacin-induced intestinal ulcers are associated with an increased number of peripheral T lymphocytes in the rat.
Indomethacin (8 mg/kg per os) induced small-intestinal ulcers which were associated with an increased percentage of total number and T-helper peripheral lymphocytes. An increase in intestinal flora and a decrease in mucosal permeability due to indomethacin treatment are among the factors which favour the cytotoxic T-cell reactions and the resulting increase in lymphocytes.
Barbacci
P
P
II Clinica Dermatologica, University of Florence, Italy.
Evangelista
S
S
D000818:Animals; D004381:Duodenal Ulcer / Q000139:chemically induced* / Q000276:immunology*; D007213:Indomethacin / Q000633:toxicity*; D007958:Leukocyte Count / Q000187:drug effects; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley; D013601:T-Lymphocytes / Q000187:drug effects*
D007213:Indomethacin