Cadmium-induced bone loss: increased susceptibility in female beagles after ovariectomy.
Bone resorption, as measured by release of bone 45Ca, was significantly increased in elderly female beagles within 96 h of exposure to 15 mg/l cadmium in drinking-water. The 45Ca response was greater in ovariectomized animals than in sham-operated controls and was not mediated by changes in calciotropic hormone concentrations. Mean blood cadmium concentrations were 3-8 micrograms/l during the earliest bone resorption response and 13-15 micrograms/l at the end of the study. During seven months of cadmium exposure, bone mineral densities decreased most in the ovariectomized animals exposed to cadmium: -15.4 +/- 4.3% for the tibia distal end and -7.2 +/- 1.2% for the lumbar vertebrae (L2-L4) (mean +/- SE, n = 4). The results indicate that cadmium may act directly on bone and that postmenopausal women exposed to cadmium in industry or via cigarette smoke may be at increased risk of cadmium-induced bone loss. They also support a direct role of cadmium in the etiopathology of itai-itai disease among postmenopausal women in Japan.
Bhattacharyya
M H
MH
Biological and Medical Research Division, Argonne National Laboratory, IL 60439-4833.
Sacco-Gibson
N A
NA
Peterson
D P
DP
D000818:Animals; D001862:Bone Resorption / Q000097:blood / Q000139:chemically induced* / Q000378:metabolism; D002104:Cadmium / Q000097:blood / Q000633:toxicity*; D002105:Cadmium Poisoning / Q000097:blood / Q000378:metabolism; D002118:Calcium / Q000145:classification / Q000378:metabolism; D002132:Calcium Radioisotopes; D004195:Disease Models, Animal; D004285:Dogs; D005260:Female; D006706:Homeostasis / Q000187:drug effects; D010024:Osteoporosis / Q000097:blood / Q000139:chemically induced* / Q000378:metabolism; D010052:Ovariectomy; D010053:Ovary / Q000502:physiology* / Q000601:surgery
D002132:Calcium Radioisotopes; D002104:Cadmium; D002118:Calcium