[Synthesis of N-(4-substituted amino-4-oxobutyryl)-N-substituted glycines].
Nine N-(4-substituted amino-4-oxobutyryl)-N-substituted glycines expected to have inhibitory activity on angiotensin-converting enzyme were synthesized. All of the title compounds and their t-butyl esters were unreported in the literature. In preliminary test in rats, compounds V2, V6 and V7 showed marked hypotensive activity.
Wu
Y
Y
School of Pharmacy, West China University of Medical Sciences, Chengdu.
Cai
C Y
CY
Gong
K S
KS
D000806:Angiotensin-Converting Enzyme Inhibitors / Q000138:chemical synthesis* / Q000737:chemistry; D000818:Animals; D000959:Antihypertensive Agents / Q000138:chemical synthesis / Q000737:chemistry; D005998:Glycine / Q000031:analogs & derivatives / Q000138:chemical synthesis* / Q000737:chemistry; D051381:Rats; D017208:Rats, Wistar; D005680:gamma-Aminobutyric Acid / Q000031:analogs & derivatives / Q000138:chemical synthesis* / Q000737:chemistry
D000806:Angiotensin-Converting Enzyme Inhibitors; D000959:Antihypertensive Agents; D005680:gamma-Aminobutyric Acid; D005998:Glycine