title: Perioperative antibiotic prophylaxis in general thoracic surgery.
abstract: A prospective study of the efficacy of ampicillin in combination with sulbactam, a beta-lactamase inhibitor, (A/S) in perioperative prophylaxis was performed. The study consisted of two independent parts performed at the same time. Part I included 60 patients with lobectomies and segmentectomies. Group A (A/S 1 x 3 g "single shot") was compared with group B (A/S 3 x 3 g). Superficial wound infections occurred in 3 patients of group A and in 2 patients of group B. There was no empyema. Bronchitis and pneumonia were found in 10 patients of group A and in 7 patients of group B. Part II examined 25 pneumonectomies receiving A/S 3 x 3 g for 3 days. Concentrations of ampicillin and sulbactam in serum and lung tissue were determined and showed adequate levels to cope with usual bacteria in lung surgery. There was one superficial wound infection, 2 cases of bronchitis, and 2 cases of pneumonia.
authors.affiliation: Department of Pulmonary Surgery, University Hospital, Freiburg, Germany.
authors.forename: H
authors.initials: H
authors.lastname: Wertzel
authors.forename: L
authors.initials: L
authors.lastname: Swoboda
authors.forename: A
authors.initials: A
authors.lastname: Joos-Würtemberger
authors.forename: U
authors.initials: U
authors.lastname: Frank
authors.forename: J
authors.initials: J
authors.lastname: Hasse
mesh_terms: D000667:Ampicillin / Q000008:administration & dosage / Q000032:analysis / Q000627:therapeutic use*; D001991:Bronchitis / Q000453:epidemiology / Q000517:prevention & control; D002180:Candidiasis, Oral / Q000453:epidemiology / Q000517:prevention & control; D004334:Drug Administration Schedule; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D007432:Intraoperative Period; D008168:Lung / Q000737:chemistry; D008297:Male; D008875:Middle Aged; D011013:Pneumonectomy; D011014:Pneumonia / Q000453:epidemiology / Q000517:prevention & control; D011183:Postoperative Complications / Q000453:epidemiology / Q000517:prevention & control*; D011184:Postoperative Period; D011446:Prospective Studies; D013407:Sulbactam / Q000008:administration & dosage / Q000032:analysis / Q000627:therapeutic use*; D013530:Surgical Wound Infection / Q000453:epidemiology / Q000517:prevention & control; D016896:Treatment Outcome; D014552:Urinary Tract Infections / Q000453:epidemiology / Q000517:prevention & control
chemical_list: D000667:Ampicillin; D013407:Sulbactam