[Effect of loratadine--selective antagonist of histamine (H1) receptor--on allergen-induced bronchoconstriction in atopic asthmatics].
The aim of this study was to evaluate the effect of loratadine on allergen-induced bronchoconstriction. The study was performed in 7 asthmatic patients with sensitivity to Dermatophagoides pteronyssinus, 4 women and 3 men. aged from 19 to 37 years. The allergen inhalatory--challenge test was performed according to Chai et al. Early phase of Dermatophagoides pteronyssinus--induced bronchoconstriction appeared in all examined patients, but late phase of bronchial obstruction was observed only in 3 persons. 30 mg orally administered of loratadine have no protect effect on early phase of allergen--induced bronchoconstriction. After loratadine ingestion the late phase of this bronchial obstruction disappeared.
Cieślewicz
G
G
Kliniki Pneumonologii i Alergologii IMW AM, Lodzi.
Gondorowicz
K
K
Grzelewska-Rzymowska
I
I
Rozniecki
J
J
Wojciechowska
B
B
D000328:Adult; D000818:Animals; D001249:Asthma / Q000175:diagnosis / Q000188:drug therapy*; D001985:Bronchial Provocation Tests; D016084:Bronchoconstriction / Q000187:drug effects*; D005260:Female; D006801:Humans; D006812:Humic Substances / Q000627:therapeutic use*; D017336:Loratadine / Q000627:therapeutic use*; D008297:Male; D008925:Mites; D012987:Soil
D006812:Humic Substances; D012987:Soil; D017336:Loratadine
Wpływ loratadyny--wybiórczego antagonisty receptorów histaminowych (H1)--na wczesna i późna faze poalergenowego skurczu oskrzeli u chorych na astme atopowa.