title: A study on conformationally restricted sangivamycins and their inhibitory abilities of protein kinases.
abstract: Conformational restrictions of sangivamycin, a rather selective inhibitor of PKC, could be achieved by the use of the steric effect and the gauche effect of the substituents on the ribofuranose moiety. The conformational deviations obtained by these methods were found to nicely correlate with the inhibitory ability of PKC.
authors.affiliation: Faculty of Engineering, Yokohama National University, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Iimori
authors.forename: Y
authors.initials: Y
authors.lastname: Murai
authors.forename: T
authors.initials: T
authors.lastname: Sugiyama
authors.forename: H
authors.initials: H
authors.lastname: Shiroto
authors.forename: T
authors.initials: T
authors.lastname: Ishizaki
authors.forename: Y
authors.initials: Y
authors.lastname: Wakizaka
authors.forename: Y
authors.initials: Y
authors.lastname: Kodama
authors.forename: S
authors.initials: S
authors.lastname: Ohuchi
authors.forename: Y
authors.initials: Y
authors.lastname: Ohtsuka
authors.forename: T
authors.initials: T
authors.lastname: Oishi
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry* / Q000494:pharmacology; D009682:Magnetic Resonance Spectroscopy; D008968:Molecular Conformation; D011493:Protein Kinase C / Q000037:antagonists & inhibitors*; D011741:Pyrimidine Nucleosides / Q000737:chemistry* / Q000494:pharmacology
chemical_list: D000900:Anti-Bacterial Agents; D011741:Pyrimidine Nucleosides; C005699:sangivamycin; D011493:Protein Kinase C