[Protective effect of verapamil and dopamine against cyclosporine-induced vasoconstriction in isolated glomeruli in rats].
Cyclosporin A (CsA)-induced nephrotoxicity is characterized by dramatic changes in glomerular filtration rate and renal plasma flow, largely limiting the clinical use of this drug. The vasoconstrictive response of CsA could explain, in part, these hemodynamic alterations. The present study compares the area changes in rat-isolated glomeruli incubated with CsA alone or after pre-treatment with verapamil and dopamine. In verapamil-pretreated CsA-intoxicated glomeruli, size decrease was reduced (-1.5 percent at T10, -3.1 percent at T20 and -4.8 percent at T30), when compared with CsA alone (-4.7 percent at T10, -10.1 percent at T20 and -12 percent at T30). The results obtained with dopamine were similar. In conclusion, verapamil and dopamine can be regarded as fair protective agents against CsA-induced vasoconstriction in rat-isolated glomeruli.
L'Azou
B
B
Groupe d'Etude de Physiologie et Physiopathologie Rénales, Facultés de Pharmacie, Bordeaux.
Lagroye
I
I
Plande
J
J
Lakhdar
B
B
Cambar
J
J
D000818:Animals; D016572:Cyclosporine / Q000494:pharmacology*; D003864:Depression, Chemical; D004298:Dopamine / Q000494:pharmacology*; D066298:In Vitro Techniques; D007668:Kidney / Q000098:blood supply; D007678:Kidney Glomerulus / Q000187:drug effects*; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley; D014661:Vasoconstriction / Q000187:drug effects*; D014700:Verapamil / Q000494:pharmacology*
D016572:Cyclosporine; D014700:Verapamil; D004298:Dopamine
Effet protecteur du vérapamil et de la dopamine à l'égard de la vasoconstriction induite par la ciclosporine sur glomérules isolés de rat.