[Experimental rationale for the feasibility of using sulacillin for the prevention of infectious complications of combined radiation and thermal injuries].
Concurrent radiation and thermal injury (IRTI) was simulated in Wistar rats. For prevention of the autoinfectious complications sulacillin, a combination of ampicillin and sulbactam, was used. The use of sulacillin was started on the onset of IRTI and continued for 7 days. The drug was administered intramuscularly twice a day. It was observed that the 8-day survival of the animals increased by more than 40 per cent and the statistical levels of bacteremia and bacterial endotoxemia significantly decreased. The experiments showed that sulacillin had no side immunodepressive effect and did not aggravate the affection of the blood system. The drug was recommended for further studies to provide evidence for rational schemes of antibacterial therapy in IRTI.
Budagov
R S
RS
Viadro
M M
MM
Makarov
G F
GF
Nesterenko
V S
VS
Polianskaia
G A
GA
Ul'ianova
L P
LP
Khlopovskaia
E I
EI
D000667:Ampicillin / Q000008:administration & dosage* / Q000009:adverse effects; D000818:Animals; D001424:Bacterial Infections / Q000517:prevention & control*; D002056:Burns / Q000150:complications*; D004338:Drug Combinations; D008297:Male; D011832:Radiation Injuries / Q000150:complications*; D051381:Rats; D017208:Rats, Wistar; D013407:Sulbactam / Q000008:administration & dosage* / Q000009:adverse effects
D004338:Drug Combinations; D000667:Ampicillin; C090243:sulacillin; D013407:Sulbactam
Eksperimental'noe obosnovanie vozmozhnosti primeneniia sulatsillina dlia profilaktiki infektsionnykh ozlozhneniĭ kombinirovannykh radiatsionno-termicheskikh porazheniĭ.