title: Altered interleukin-1 production in mice exposed to rotation stress.
abstract: This study examined the effects of rotation stress (78 circles per 1 min for 1 h: 10 min rotation + 5 min interval) on peritoneal macrophage release of lymphocyte-activating factors (LAF) and interleukin-1 alpha (IL-1 alpha) concentration in mice (CBA x C57BL6)F1. Rotation stress induced the macrophages' release of LAF with peak reactions in 0-1 h after termination of stress, followed by elevation of plasma IL-1 alpha. Induction of LAF release was accompanied by a higher concentration of corticosterone (Cs) in the blood, most prominent at 0 and 0.5 h after termination of the stressful procedure, and recovering to normal values 1 h later. It is suggested that the stimulating effect of stress on LAF and IL-1 production possibly involves glucocorticoid hormones, as well as other stress-induced neurohumoral shifts accompanying the reaction of glucocorticoids. It is also possible that the activated production of LAF and IL-1 by macrophages has a stress-limiting role in cases of mild stress.
authors.affiliation: Institute of Experimental Medicine, USSR Academy of Medical Science, St. Petersburg, Russia.
authors.forename: E A
authors.initials: EA
authors.lastname: Korneva
authors.forename: E G
authors.initials: EG
authors.lastname: Rybakina
authors.forename: E E
authors.initials: EE
authors.lastname: Fomicheva
authors.forename: I A
authors.initials: IA
authors.lastname: Kozinets
authors.forename: E K
authors.initials: EK
authors.lastname: Shkhinek
mesh_terms: D000818:Animals; D002478:Cells, Cultured; D007375:Interleukin-1 / Q000096:biosynthesis*; D008264:Macrophages / Q000378:metabolism; D008297:Male; D051379:Mice; D012399:Rotation; D013312:Stress, Physiological / Q000378:metabolism*
chemical_list: D007375:Interleukin-1