[The effect of prostacyclin and its synthetic analog MM-706 on kidney function in corrosive sublimate-induced nephropathy].
The effects of prostacyclin and its stable analogue MM-706 on renal function were examined in rats with sublimate nephropathy. Prostacyclin was shown to attenuate renal dysfunctions by increasing glomerular filtration rate and water and salt reabsorption. MM-706 produced more pronounced protective effects and restored the filtration and reabsorption up to the level observed in control rats.
Kukharchuk
A L
AL
Gozhenko
A I
AI
Lille
Iu E
IuE
Loppe
M
M
D000818:Animals; D004353:Drug Evaluation, Preclinical; D011464:Epoprostenol / Q000031:analogs & derivatives* / Q000627:therapeutic use*; D007668:Kidney / Q000187:drug effects* / Q000503:physiopathology; D007674:Kidney Diseases / Q000097:blood / Q000139:chemically induced / Q000188:drug therapy* / Q000503:physiopathology; D008297:Male; D008627:Mercuric Chloride; D051381:Rats
C081773:MM 706; D008627:Mercuric Chloride; D011464:Epoprostenol
Vliianie prostatsiklina i ego sinteticheskogo analoga MM-706 na funktsional'noe sostoianie pochek pri sulemovoĭ nefropatii.