title: A comparative study of gluconolactone versus benzoyl peroxide in the treatment of acne.
abstract: Alpha hydroxy acids (AHA's) or "fruit acids" are a special group of organic acids found in many natural foods. They have been described in the literature for the treatment of a number of conditions in which abnormal keratinization consistently contributes to pathogenesis. These include the icthyoses, warts, psoriasis, eczema and acne. We have performed a double-blind clinical trial on 150 patients to evaluate the efficacy and skin tolerance of the alpha hydroxy acid gluconolactone 14% in solution (Nuvoderm lotion) in the treatment of mild to moderate acne when compared with its vehicle (placebo) and 5% benzoyl peroxide lotion. The results of this study showed that both gluconolactone and benzoyl peroxide had a significant effect in improving patients' acne by reducing the number of lesions (inflamed and non-inflamed). Furthermore, fewer side-effects were experienced by patients treated with gluconolactone when compared with benzoyl peroxide.
authors.affiliation: Department of Dermatology, Royal Prince Alfred Hospital, Camperdown, NSW.
authors.forename: M J
authors.initials: MJ
authors.lastname: Hunt
authors.forename: R S
authors.initials: RS
authors.lastname: Barnetson
mesh_terms: D000152:Acne Vulgaris / Q000188:drug therapy* / Q000473:pathology; D000279:Administration, Cutaneous; D000293:Adolescent; D000328:Adult; D001585:Benzoyl Peroxide / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D004311:Double-Blind Method; D005260:Female; D005942:Gluconates / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D006801:Humans; D007783:Lactones; D008297:Male; D010919:Placebos; D011446:Prospective Studies; D012867:Skin / Q000187:drug effects / Q000473:pathology; D012871:Skin Diseases / Q000139:chemically induced; D013997:Time Factors
chemical_list: D005942:Gluconates; D007783:Lactones; D010919:Placebos; D001585:Benzoyl Peroxide; C010730:beta-glucono-1,5-lactone