Interleukin-8 receptor-mediated chemotaxis of normal human epidermal cells.
Normal human keratinocytes show chemotactic behavior towards interleukin-8 (IL-8). Under physiological conditions this cytokine seems to be present in an equilibrium between monomeric and dimeric forms, as indicated by Western blotting data. Radioligand binding studies suggest that keratinocyte chemotaxis is mediated by receptors specific for IL-8 dimers. IL-8 receptor-specific mRNA can be detected in a keratinocyte cell line by polymerase chain reaction.
Michel
G
G
Department of Dermatology, University of Munich, Germany.
Kemény
L
L
Peter
R U
RU
Beetz
A
A
Ried
C
C
Arenberger
P
P
Ruzicka
T
T
D016475:3T3 Cells / Q000378:metabolism; D000818:Animals; D001483:Base Sequence; D002478:Cells, Cultured; D002633:Chemotaxis / Q000502:physiology; D006801:Humans; D016209:Interleukin-8 / Q000378:metabolism* / Q000502:physiology; D015603:Keratinocytes / Q000378:metabolism* / Q000502:physiology; D051379:Mice; D008969:Molecular Sequence Data; D009504:Neutrophils / Q000378:metabolism; D011869:Radioligand Assay; D011971:Receptors, Immunologic / Q000378:metabolism* / Q000502:physiology; D023062:Receptors, Interleukin-8A
D016209:Interleukin-8; D011971:Receptors, Immunologic; D023062:Receptors, Interleukin-8A