[Effect of various antianginal agents on the frequency and duration of myocardial ischemic episodes in patients with stable angina pectoris].
The effects of verapamil, nifedipine, propranolol, and combinations of nifedipine+propranolol and nifedipine+verapamil were studied in 60 patients with stable angina pectoris. Verapamil was found to have a pronounced antianginal activity against all types of myocardial ischemia, whereas nifedipine relieved mainly painful ischemic episodes. By the end of 12-week therapy with propranolol, the agent lost its antiischemic effect in a third of patients, which was accompanied by an increase in the number and severity of silent ischemic episodes.
Voronkov
L G
LG
Lysenko
A F
AF
D000787:Angina Pectoris / Q000188:drug therapy* / Q000503:physiopathology; D004359:Drug Therapy, Combination; D006801:Humans; D017202:Myocardial Ischemia / Q000188:drug therapy / Q000503:physiopathology; D009543:Nifedipine / Q000627:therapeutic use*; D010507:Periodicity; D011433:Propranolol / Q000627:therapeutic use*; D013997:Time Factors; D014700:Verapamil / Q000627:therapeutic use*
D011433:Propranolol; D014700:Verapamil; D009543:Nifedipine
Vliianie razlichnykh antianginalńykh sredstv na chastotu i prodolzhitelńost epizodov ishemii miokarda u bolńykh so stabilńoĭ stenokardieĭ.