[Evaluation of long-term efficacy on plasma-derived hepatitis B vaccine].
From April 1986 to May 1990, 265 pupils aged 5 to 9 years in Xian suburbs were studied to evaluate long-term efficacy of plasma-derived hepatitis B vaccine made in China. Anti-HBs titers in vaccine group reached the highest at twelfth month after the first injection and decreased afterwards. The positive rate of anti-HBs decreased slow, but geometric mean titers of anti-HBs fell sharply. Compared with placebo group, the differences were all significant. The peak anti-HBs titers and the response time positively correlated with the persistence of anti-HBs. 4 years observation showed that protection rate of hepatitis B vaccine against HBV infection was 80%. Protection rate was 100% if HBsAg was only considered.
Xu
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Department of Epidemiology, Xian Medical University.
D002648:Child; D002675:Child, Preschool; D004311:Double-Blind Method; D005260:Female; D006509:Hepatitis B / Q000517:prevention & control*; D006510:Hepatitis B Antibodies / Q000097:blood; D006514:Hepatitis B Surface Antigens / Q000276:immunology; D017325:Hepatitis B Vaccines / Q000276:immunology; D006515:Hepatitis B virus / Q000276:immunology*; D006801:Humans; D008297:Male
D006510:Hepatitis B Antibodies; D006514:Hepatitis B Surface Antigens; D017325:Hepatitis B Vaccines