[Spontaneous proliferative activity of lymphocytes in normal and EPH gestosis complicated pregnancy].
The spontaneous proliferative activity of lymphocytes and CD4+/CD8+ ratio has been estimated in normal and EPH gestosis-affected pregnancy; also the effects of autologous and allogenic sera on this lymphocyte activity was evaluated. Although in normal pregnancy there was a very low CD4+/CD8+ ratio, the spontaneous proliferative activity of lymphocytes and the effects of autologous sera exerted thereupon were the same in either healthy pregnant women or in non-pregnant controls, what indicates a normal cellular immunity in physiological pregnancy. In gestosis an increased proliferative activity of lymphocytes and very high CD4+/CD8+ ratio was observed, when referred to non-pregnant controls. The serum of normal pregnant women did not reveal any immunosuppressive features against the activity of both autologous lymphocytes and gestosis--affected pregnancy, whereas it clearly inhibited the lymphocyte proliferation in non-pregnant controls. A different model of the autologous sera effects on the lymphocyte activity in gestosis women--when compared with the other examined women--is an evidence for altered immuno-modulating parameters of the serum in question.
Malinowski
A
A
Katedry Połoznictwa i Ginekologii WAM, Lodzi.
Szpakowski
M
M
Tchórzewski
H
H
Zeman
K
K
Kowalczyk
T
T
Oszukowski
P
P
D016516:CD4-CD8 Ratio; D005260:Female; D006801:Humans; D008213:Lymphocyte Activation / Q000276:immunology*; D008214:Lymphocytes / Q000276:immunology*; D011225:Pre-Eclampsia / Q000276:immunology*; D011247:Pregnancy / Q000276:immunology*; D012016:Reference Values
Samoistna aktywność proliferacyjna limfocytów oraz stosunek komórek CD4+ do CD8+ u kobiet w ciazy prawidłowej i powikłanej gestoza EPH.