Physiological activities of S-(1,2-dicarboxyethyl)glutathione as an intrinsic tripeptide present in liver, heart and lens.
S-(1,2-Dicarboxyethyl)glutathione (DCE-GS, CAS 1115-52-2) found in rat liver, heart and lens in considerable amounts, showed an anti-inflammatory effect, which was evaluated by testing the inhibition of the experimental conjunctival edema of rats. An intravenous injection (3 mg/kg) prior to the carrageenan injection prevented the conjunctive edema formation by up to 30%. This peptide also inhibited the histamine release from rat mast cells induced by the compound 48/80. The peptide was added to the mast cells before addition of the compound 48/80 and an inhibition of the histamine release up to 96% at a 1 mmol/l concentration occurred. Furthermore, it displayed an antianaphylactic effect in rats using antibody against chicken egg albumin. An injection of the peptide (30 mg/kg) prior to the antigen administration inhibited color deposition up to 43%. Analogues or derivatives of DCE-GS were synthesized and tested for those inhibitory activities. However, there was no other peptide having stronger effects than DCE-GS and little structure-activity relationship among them.
Sakaue
T
T
Senju Pharmaceutical Co., Itami, Japan.
Ohhira
M
M
Ogata
K
K
Ohmori
S
S
D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology; D003231:Conjunctivitis / Q000188:drug therapy; D005978:Glutathione / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000494:pharmacology / Q000502:physiology; D006321:Heart / Q000187:drug effects*; D006636:Histamine Release / Q000187:drug effects; D066298:In Vitro Techniques; D007908:Lens, Crystalline / Q000378:metabolism*; D008099:Liver / Q000378:metabolism*; D008297:Male; D008407:Mast Cells / Q000187:drug effects; D009206:Myocardium / Q000378:metabolism; D010047:Ovalbumin / Q000276:immunology; D010323:Passive Cutaneous Anaphylaxis / Q000187:drug effects; D010455:Peptides / Q000138:chemical synthesis / Q000494:pharmacology / Q000502:physiology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D013329:Structure-Activity Relationship; D003189:p-Methoxy-N-methylphenethylamine / Q000494:pharmacology
D000894:Anti-Inflammatory Agents, Non-Steroidal; D010455:Peptides; C041581:S-(1,2-dicarboxyethyl)glutathione; D003189:p-Methoxy-N-methylphenethylamine; D010047:Ovalbumin; D005978:Glutathione