[Sensitivity of microflora isolated in the process of preparing solizyme to antimicrobial drugs].
Microorganisms isolated from intermediate products of microbial lipase (solysime) and auxiliary raw materials, reagents and water used in the production of the enzyme belonged to diverse taxonomic groups. They were mainly susceptible to antibiotics (aminoglycosides, rifampicin, chloramphenicol and others) as well as to antiseptics and chemotherapeutics. However, certain isolates were moderately resistant to some of the antimicrobial agents (they were more frequent among Pseudomonas spp.). The bacteriostatic action of many of the drugs was more pronounced than the bactericidal one. It was especially evident after increasing of the microbial load (from 10(5) to 10(8) CFU/ml). At a temperature of 10 degrees C against 37 degrees C the susceptibility of the cultures to the bactericidal action of the drugs usually decreased.
Karlamova
Iu A
IuA
D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D000891:Anti-Infective Agents, Local / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects* / Q000302:isolation & purification; D008049:Lipase / Q000096:biosynthesis*; D008826:Microbial Sensitivity Tests; D013696:Temperature
D000900:Anti-Bacterial Agents; D000891:Anti-Infective Agents, Local; C081378:solysime; D008049:Lipase
Chuvstvitel'nost' mikroflory, vydelennoĭ v protsesse polucheniia solizima, k antimikrobnym preparatam.