[The effect of milk consumption on the activity of the formaldehyde detoxification system in sensitization to this compound].
The activity of formaldehyde dehydrogenase (FDG) and total nonspecific formaldehyde oxidative activity of nasal mucosa and liver and the amount of reduced glutathione in the liver were measured in guinea pig subjected to epicutaneous or inhalative action of formaldehyde and additionally fed with cow milk. Glutathione-deficient animals demonstrated an increase in FDG activity following formaldehyde sensitization both in the liver and in nasal mucosa, whereas FDG activity in glutathione-supplied animals did not change significantly. The concentration of formaldehyde in the internal environment is supposed to be controlled by the levels of coenzyme (reduced glutathione) and FDG activity.
Pestova
M I
MI
Gmoshinskiĭ
I V
IV
Mazo
V K
VK
D000445:Aldehyde Oxidoreductases / Q000378:metabolism; D000818:Animals; D004342:Drug Hypersensitivity / Q000201:enzymology*; D005557:Formaldehyde / Q000008:administration & dosage / Q000493:pharmacokinetics*; D005978:Glutathione / Q000378:metabolism; D006168:Guinea Pigs; D008658:Inactivation, Metabolic; D008099:Liver / Q000201:enzymology; D008297:Male; D008892:Milk; D009297:Nasal Mucosa / Q000201:enzymology; D010084:Oxidation-Reduction
D005557:Formaldehyde; C020145:formaldehyde dehydrogenase (glutathione); D000445:Aldehyde Oxidoreductases; D005978:Glutathione
Vliianie potrebleniia moloka na aktivnost' sistemy detoksikatsii formal'degida pri sensibilizatsii étim soedineniem.