Possible transplacental transmission of human papillomaviruses.
OBJECTIVE
The objective of this study was to examine the possibility of intrauterine human papillomavirus infection of fetuses by transplacental transmission of human papillomavirus before delivery.


METHODS
Specimens of cervicovaginal cells and peripheral blood mononuclear cells were obtained from 52 consecutive pregnant women in the third trimester of pregnancy. Cord blood specimens were also obtained from the neonates born to these mothers. Presence of human papillomavirus types 16 and 18 deoxyribonucleic acid was analyzed by an in vitro enzymatic deoxyribonucleic acid amplification method.


RESULTS
Human papillomavirus type 16 deoxyribonucleic acid was found in 6 (11.5%) cervicovaginal and in 9 (17.3%) peripheral blood mononuclear cell specimens. Seven cord blood specimens from neonates born to mothers who were positive for peripheral blood mononuclear cell human papillomavirus type 16 deoxyribonucleic acid were found to contain human papillomavirus type 16 deoxyribonucleic acid. One cervicovaginal and two peripheral blood mononuclear cell specimens contained human papillomavirus type 18 deoxyribonucleic acid, but none of the cord blood specimens contained human papillomavirus type 18 deoxyribonucleic acid.


CONCLUSIONS
These results seem to suggest possible transplacental transmission of the virus and the potential association of such transmission with the status of human papillomavirus in peripheral blood mononuclear cells.
Tseng
C J
CJ
Department of Obstetrics and Gynecology, Chang Gung Memorial Hospital and Medical College, KweiShan, TaoYuan, Taiwan, Republic of China.
Lin
C Y
CY
Wang
R L
RL
Chen
L J
LJ
Chang
Y L
YL
Hsieh
T T
TT
Pao
C C
CC
D001483:Base Sequence; D002584:Cervix Uteri / Q000382:microbiology; D004279:DNA, Viral / Q000032:analysis; D005260:Female; D005312:Fetal Blood / Q000382:microbiology; D006801:Humans; D007963:Leukocytes, Mononuclear / Q000382:microbiology; D008969:Molecular Sequence Data; D027383:Papillomaviridae / Q000235:genetics; D016133:Polymerase Chain Reaction; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000382:microbiology*; D011263:Pregnancy Trimester, Third; D014412:Tumor Virus Infections / Q000382:microbiology / Q000635:transmission*; D014621:Vagina / Q000382:microbiology
D004279:DNA, Viral