[Spasmolytic and antinoradrenergic activities of para-hydroxybenzonitrile on the isolated duodenum and vas deferens in rats].
The para-hydroxy-benzonitrile (PHB) show spasmolytic activity of the muscular of duodenum provoked by acetylcholine or barium chloride. The results obtained on the vas deferent of the rat versus the contracture effects of norepinephrine show that PHB is an antagonist of the neuromediator on the post-synaptic alpha adrenoceptors.
Cheav
S L
SL
Laboratoire de Pharmacodynamie, UFR de Pharmacie, Tours.
Chahine
R
R
Kirkiacharian
S
S
Piéri
F
F
D000109:Acetylcholine / Q000494:pharmacology; D000818:Animals; D001464:Barium / Q000494:pharmacology; D017609:Barium Compounds; D002712:Chlorides / Q000494:pharmacology; D004347:Drug Interactions; D004386:Duodenum / Q000187:drug effects*; D008297:Male; D009570:Nitriles / Q000494:pharmacology; D009638:Norepinephrine / Q000037:antagonists & inhibitors*; D010276:Parasympatholytics; D000091402:Prohibitins; D051381:Rats; D017207:Rats, Sprague-Dawley; D014649:Vas Deferens / Q000187:drug effects*
D017609:Barium Compounds; D002712:Chlorides; D009570:Nitriles; D010276:Parasympatholytics; C000717332:Phb protein, rat; D000091402:Prohibitins; C024986:barium chloride; D001464:Barium; C014356:benzonitrile; D000109:Acetylcholine; D009638:Norepinephrine
Activités spasmolytique et antinoradrénergique du para-hydroxybenzonitrile sur le duodénum et le canal déférent isolés du rat.