Amelioration of radiation damage to haemopoiesis by Ivastimul, given after irradiation to mice protected by peroral cystamine.
The combined radioprotection by preirradiation peroral cystamine and postirradiation Ivastimul treatment was examined in sublethally and lethally whole-body gamma-irradiated mice. The enhancement of haemopoietic recovery and increased survival of irradiated mice was demonstrated when a single dose of Ivastimul was administered after irradiation. Ameliorative influence of combined radioprotection may be explained by the haemopoietic stem cell protection by cystamine and haemopoietic stimulation mediated by Ivastimul.
Vacek
A
A
Institute of Biophysics, Czechoslovak Academy of Sciences, Brno.
Rotkovská
D
D
Bartonícková
A
A
Kautská
J
J
D000818:Animals; D001854:Bone Marrow Cells; D002708:Chlorella; D003433:Crosses, Genetic; D003538:Cystamine / Q000627:therapeutic use*; D004359:Drug Therapy, Combination; D015672:Erythroid Precursor Cells / Q000528:radiation effects; D005720:Gamma Rays; D006098:Granulocytes / Q000528:radiation effects; D006410:Hematopoiesis / Q000528:radiation effects*; D008264:Macrophages / Q000528:radiation effects; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D010936:Plant Extracts; D011833:Radiation Injuries, Experimental / Q000188:drug therapy*; D011837:Radiation-Protective Agents / Q000627:therapeutic use*; D016019:Survival Analysis; D013997:Time Factors; D014916:Whole-Body Irradiation
D010936:Plant Extracts; D011837:Radiation-Protective Agents; C061794:ivastimul; D003538:Cystamine