[A study of vitamin inhibition on the mutagenicity of the antineoplastic drugs].
The inhibitory effects on the mutational specificity of antineoplastic drugs of 14 kinds of vitamin were tested with the method of mutational and anti-mutational synchoronous test, add S9 and no S9. Vit C, Vit B6, and nicotinic acid had distinct inhibitory effects on the mutational specificity of 6 antineoplastic drugs, namely, mitomycin C, bleomycin, fluorouracil, cis-Diaminodichloroplatinum, arabinosylcytosine and mustargen Vit K3 showed inhibitory effect to mitomycin C, fluorouracil, cis-diaminodichloroplatinum, and arabinosylcytosine but Vit AD, Vit B1, Vit B2, Vit Bco, Vit D3, Vit E, Rutin, Vit K1, Vit K4 and folic acid did not. The fact that Vit C, Vit B6, nicotinic acid and Vit K3 showed anti-mutational effects is of some significance with reference to clinical therapeutics and prevention of tumours.
Zhao
Z Z
ZZ
Hebei Cancer Institute, Shi Jiazhuang.
Huang
M T
MT
D016587:Antimutagenic Agents / Q000494:pharmacology*; D000970:Antineoplastic Agents / Q000633:toxicity*; D001205:Ascorbic Acid / Q000494:pharmacology; D004926:Escherichia coli / Q000187:drug effects / Q000235:genetics; D009152:Mutagenicity Tests; D009539:Nicotinic Acids / Q000494:pharmacology; D011736:Pyridoxine / Q000494:pharmacology; D013014:SOS Response, Genetics / Q000187:drug effects; D014815:Vitamins / Q000494:pharmacology*
D016587:Antimutagenic Agents; D000970:Antineoplastic Agents; D009539:Nicotinic Acids; D014815:Vitamins; D011736:Pyridoxine; D001205:Ascorbic Acid