title: Double monoclonal cryoglobulinemia, glomerulonephritis and lymphoma.
abstract: We present a case of monoclonal cryoglobulinemia with double monoclonal component IgA lambda-IgG lambda, without complement activation, membranoproliferative glomerulonephritis (MPGN) with deposits of IgA, IgG and lambda chains and lymphocytic IgA-lambda-chain-secreting lymphoma. This case emphasizes the possibility that double monoclonal cryoglobulins could behave differently compared to type I cryoglobulins, determining a MPGN-like type II cryoglobulins do, but without activating the complement cascade.
authors.affiliation: Service de Néphrologie, Centre Hospitalier Universitaire, Grenoble, France.
authors.forename: C
authors.initials: C
authors.lastname: Rollino
authors.forename: A
authors.initials: A
authors.lastname: Dieny
authors.forename: F
authors.initials: F
authors.lastname: Le Marc'hadour
authors.forename: J C
authors.initials: JC
authors.lastname: Renversez
authors.forename: N
authors.initials: N
authors.lastname: Pinel
authors.forename: D
authors.initials: D
authors.lastname: Cordonnier
mesh_terms: D015703:Antigens, CD / Q000032:analysis; D000951:Antigens, Neoplasm / Q000276:immunology; D002999:Clone Cells; D003449:Cryoglobulinemia / Q000150:complications*; D015322:Gene Rearrangement, B-Lymphocyte; D015432:Glomerulonephritis, Membranoproliferative / Q000209:etiology* / Q000276:immunology / Q000473:pathology; D006801:Humans; D008223:Lymphoma / Q000150:complications* / Q000276:immunology / Q000473:pathology; D008297:Male; D008875:Middle Aged; D013154:Spleen / Q000473:pathology
chemical_list: D015703:Antigens, CD; D000951:Antigens, Neoplasm