[Accidental ultrasonographic disclosure of isolated intra-abdominal fetal hyperechogenicity. Apropos of a series of 87 cases].
Having seen 87 cases we will now attempt to refine the management to be carried out when intra-abdominal hyperechogenic masses are found in the fetus. Before the 20th week of amenorrhoea (47 cases) amniocentesis can be used to study the digestive enzymes to determine the fetal karyotype. The normal results for intestinal enzymes makes it possible to rule out fetal cystic fibrosis. Three karyotype abnormalities were found in this series. After the 20th week (40 cases) intestinal enzymes cannot be interpreted. The diagnosis of cystic fibrosis then must rely on Delta F 508 mutation; but the absence of this mutation does not exclude cystic fibrosis. When ultrasound signs of intra-abdominal hyperechogenicity are found the diagnosis of cystic fibrosis should not be thought of first, because in this series the majority of fetuses who had this sign were born without any malformation. Four cases of cystic fibrosis that were confirmed have been found but equally there were other serious malformations, three chromosome abnormalities, four intestinal atresias, ten unexplained intra-uterine deaths and one case of biliary duct atresia.
Muller
F
F
Hôpital Ambroise-Paré, F 92104 Boulogne.
Simon-Bouy
B
B
Aubry
M C
MC
Duchatel
F
F
Bessis
R
R
Boué
J
J
D000653:Amniotic Fluid / Q000201:enzymology; D000013:Congenital Abnormalities / Q000000981:diagnostic imaging; D003550:Cystic Fibrosis / Q000175:diagnosis* / Q000235:genetics; D005260:Female; D005819:Genetic Markers / Q000235:genetics; D005865:Gestational Age; D006801:Humans; D007621:Karyotyping; D011247:Pregnancy; D011446:Prospective Studies; D016216:Ultrasonography, Prenatal
D005819:Genetic Markers
Découverte fortuite à l'échographie d'une hyperéchogénicité intra-abdominale foetale isolée. A propos d'une série de 87 cas.