[The effect of the acid exopolysaccharide produced by the causative agent of melioidosis on macrophage function].
Acid exopolysaccharide of the melioidosis agent, isolated from the slime of alysogenic strain of Pseudomonas pseudomallei SVBDO-141 inhibits the capture of sheep erythrocytes--55Fe by mouse peritoneal macrophages. Administration of the sheep erythrocytes--55Fe, sensibilized by acid exopolysaccharide was proved not to have an antiphagocytic effect. Inhibition of phagocytic macrophagal activity depends on the conditions of isolation of acid exopolysaccharide.
Bozhko
V G
VG
Denisov
I I
II
Rybkin
V S
VS
Popov
S F
SF
Vasil'ev
V P
VP
D000818:Animals; D016957:Burkholderia pseudomallei; D004305:Dose-Response Relationship, Drug; D004912:Erythrocytes / Q000276:immunology; D008264:Macrophages / Q000187:drug effects / Q000276:immunology; D051379:Mice; D008807:Mice, Inbred BALB C; D010529:Peritoneal Cavity / Q000166:cytology; D010587:Phagocytosis / Q000187:drug effects; D011135:Polysaccharides, Bacterial / Q000302:isolation & purification / Q000494:pharmacology*
D011135:Polysaccharides, Bacterial
Vliianie kislogo ékzopolisakharida, produtsiruemogo vozbuditelem melioidoza, na funktsional'nuiu aktivnost' makrofagov.