Changes in platelet membrane glycoproteins during blood bank storage.
The literature on membrane glycoprotein changes occurring during platelet storage is reviewed. Technical problems which may have biased reports are clarified, and the consensus of current studies is established. The membrane alterations that occur during blood bank storage are reminiscent of the surface changes which result from platelet secretion: an increased surface concentration of GP IIb-IIIa and GMP-140, and the appearance of platelet membrane microparticles in the supernatant plasma. The clinical importance of these changes is unknown. Future directions for research on the structure and function of stored platelets are discussed.
George
J N
JN
Hematology-Oncology Section University of Oklahoma Health Sciences Center, Oklahoma City 73190.
D001792:Blood Platelets / Q000737:chemistry* / Q000378:metabolism / Q000648:ultrastructure; D001793:Blood Preservation; D006801:Humans; D008954:Models, Biological; D019007:P-Selectin; D015539:Platelet Activation; D010980:Platelet Membrane Glycoproteins / Q000737:chemistry*; D013696:Temperature; D013997:Time Factors
D019007:P-Selectin; D010980:Platelet Membrane Glycoproteins