[Structure an functions of IgG subclasses].
This review first deals with IgG subclasses according to the aspects that ascribe them their common class properties: general structure, enzymatic cleavage, synthesis, Gm allotypes. Then the subclass specific characteristics are described, comparing the main structural features (domains, hinge, disulfide bridges, kappa/lambda ratio). The IgG subclasses are further compared according to their effector functions, stressing those resulting from structural differences: classical pathway of complement activation, binding to Fc receptors, to protein A and to rheumatoid factors. Finally, a survey of the prolific works about antibody functions of IgG subclasses, allows a glimpse of the wide possible applications in this field.
Chatron
P
P
Laboratoire Monier-Chatron, Clermont-Ferrand, France.
Pontet
F
F
D000367:Age Factors; D006801:Humans; D007074:Immunoglobulin G / Q000737:chemistry / Q000145:classification* / Q000235:genetics / Q000378:metabolism; D007129:Immunoglobulin Gm Allotypes / Q000235:genetics; D013329:Structure-Activity Relationship
D007074:Immunoglobulin G; D007129:Immunoglobulin Gm Allotypes
Structure et fonctions des sous-classes d'IgG.