[The effect of cholinergic-potentiating and cholinergic-blocking agents on reparative processes in the damaged gastric mucosa of rats].
Rat experiments have indicated that increased lipid peroxidation in gastric tissue occurs with formation of cryogenic gastric ulcers. The use of methacin alone, 1 mg/kg i.p., and in combination with proserinum, 0.1 mg/kg, s.c., metamisyl alone, 1 mg/kg, i. p., and in combination with galanthamine hydrobromide, 1 mg/kg, s. c., result in acceleration of reparative process in the rat gastric walls and normalization of gastric tissue malonic dialdehyde levels. Methacin in combination with proserinum has been found to be most beneficial.
Losev
N A
NA
Kuznetsova
N N
NN
D000818:Animals; D004353:Drug Evaluation, Preclinical; D004359:Drug Therapy, Combination; D005753:Gastric Mucosa / Q000187:drug effects* / Q000378:metabolism; D015227:Lipid Peroxidation / Q000187:drug effects; D008297:Male; D008315:Malondialdehyde / Q000378:metabolism; D010276:Parasympatholytics / Q000627:therapeutic use*; D010277:Parasympathomimetics / Q000627:therapeutic use*; D051381:Rats; D013276:Stomach Ulcer / Q000188:drug therapy / Q000378:metabolism; D013997:Time Factors; D014945:Wound Healing / Q000187:drug effects
D010276:Parasympatholytics; D010277:Parasympathomimetics; D008315:Malondialdehyde
Vliianie kholinopotentsiruiushchikh i kholinoblokiruiushchikh sredstv na reparativnye protsessy v povrezhdennoĭ slizistoĭ obolochki zheludka krys.