Effect of diethylcarbamazine on acetylcholine and gamma amino butyric acid in Setaria digitata.
In vitro studies on the effect of neurotransmitter amino acids and amines on the motility of S. digitata showed that acetylcholine (Ach) had a stimulatory and gama amino butyric acid (GABA) an inhibitory effect on the parasite. When the worms were incubated in different concentrations of diethylcarbamazine there was a significant dose related increase in the level of Ach, and the level of GABA remained unchanged. Inhibition of acetylcholine esterase activity by diethylcarbamazine caused the accumulation of Ach in the synapses resulting in receptor desensitization and after a momentary stimulation causes paralysis of the parasite.
Vijayanathan
L
L
Department of Biochemistry, University of Kerala, Kariyavattom, Trivandrum, India.
Raj
R K
RK
D000109:Acetylcholine / Q000494:pharmacology*; D000110:Acetylcholinesterase / Q000096:biosynthesis; D000818:Animals; D004049:Diethylcarbamazine / Q000494:pharmacology*; D005968:Glutamate Decarboxylase / Q000096:biosynthesis; D009068:Movement / Q000187:drug effects; D017182:Setaria Nematode / Q000187:drug effects* / Q000502:physiology; D005680:gamma-Aminobutyric Acid / Q000494:pharmacology*
D005680:gamma-Aminobutyric Acid; D000110:Acetylcholinesterase; D005968:Glutamate Decarboxylase; D000109:Acetylcholine; D004049:Diethylcarbamazine