[Effects of Se-enriched malt cakes on UV benzo(a)pyrene induced unscheduled DNA synthesis of lymphocytes from high risk population of lung cancer].
Se-malt cakes containing 300 micrograms selenium were given daily to men from high risk area of lung cancer and the influence of ultraviolet light (UV) and be benzo(a)pyrene (B(a)P) induced unscheduled DNA synthesis (UDS) of peripheral lymphocytes were determined. After Se-supplementation for 6 months, the Se levels in serum, hairs and activity of GSH-px were increased by 89%, 67% and 178%, respectively. The ratio of UV-induced UDS was decreased from the mean value of 2.47 in the control to 1.61 (P < 0.05) in the Se-group. After Se-intake for one year, the Se levels were elevated by 78% in serum, 83% in hairs and 56% in GSH-px activity, while the mean value of B alpha P-induced UDS was reduced from 2.21 in the control to 1.47 (P < 0.05) in the Se-group. The results of the present study indicate a blocking effect of Se-supplementation to UV- and B alpha P-induced UDS of peripheral lymphocytes from high risk subjects for lung cancer.
Chen
W Q
WQ
Cancer Institute, Chinese Academy of Medical Sciences, Beijing.
D000328:Adult; D001564:Benzo(a)pyrene; D004247:DNA / Q000096:biosynthesis*; D004249:DNA Damage / Q000187:drug effects*; D004260:DNA Repair / Q000187:drug effects; D005526:Food, Formulated; D005979:Glutathione Peroxidase / Q000378:metabolism; D006197:Hair / Q000378:metabolism; D006801:Humans; D008175:Lung Neoplasms / Q000209:etiology; D008214:Lymphocytes / Q000187:drug effects* / Q000528:radiation effects; D008297:Male; D008875:Middle Aged; D012306:Risk; D012643:Selenium / Q000378:metabolism / Q000494:pharmacology*; D014466:Ultraviolet Rays
D001564:Benzo(a)pyrene; D004247:DNA; D005979:Glutathione Peroxidase; D012643:Selenium