Efficacy of L-627, a new carbapenem, in the treatment of experimentally induced intra-abdominal infections in rats.
A reproducible experimental model of intra-abdominal infections in rats has been devised in order to simulate intra-abdominal sepsis in patients. Pre-operatively, the rats were fed lean ground beef for two weeks in order to change the intestinal flora to one similar to that of humans. A 1-cm segment of ileum was isolated on its vascular pedicle. The intestine was then divided at each end of the segment and intestinal continuity was re-established by an end-to-end anastomosis. The segment of ileum was then returned to the abdominal cavity. This experimental model was used to compare the efficacy of L-627 with the combination of gentamicin plus metronidazole. Eighty per cent of the untreated animals died within three days. Animals treated with L-627 or gentamicin plus metronidazole had significantly decreased mortality and increased cure rates during the experimental period. Only two animals in the two treatment groups died. L-627 seems to be as useful as gentamicin plus metronidazole in the treatment of intra-abdominal infections.
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Department of Microbiology, Karolinska Institute, Huddinge University Hospital, Sweden.
Lahnborg
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D000005:Abdomen; D000818:Animals; D001424:Bacterial Infections / Q000188:drug therapy* / Q000382:microbiology; D015780:Carbapenems / Q000627:therapeutic use*; D004195:Disease Models, Animal; D005839:Gentamicins / Q000627:therapeutic use; D007422:Intestines / Q000502:physiology / Q000601:surgery; D008297:Male; D008795:Metronidazole / Q000627:therapeutic use; D051381:Rats; D017207:Rats, Sprague-Dawley; D013845:Thienamycins / Q000627:therapeutic use*
D015780:Carbapenems; D005839:Gentamicins; D013845:Thienamycins; D008795:Metronidazole; C065257:biapenem