title: Diagnostic tests for dry eye disease in normals and dry eye patients with and without Sjögren's syndrome.
abstract: In order to compare the diagnostic tests for dry eye disease and the results of conjunctival impression cytology, we examined three groups of eyes: 146 eyes of normal controls, 108 eyes of keratoconjunctivitis sicca (KCS) patients without Sjögren's syndrome (SS) and 102 eyes of patients with SS. The clinical tests (break-up time, Schirmer test, Rose Bengal staining) and conjunctival impression cytology specimens from the superior part of the bulbar conjunctiva were evaluated from all the eyes. Our results showed that the patients with KCS without SS have abnormal lacrimal tests (p < 0.001) without changes in impression cytology [nucleo/cytoplasmic ratio (N/C), p > 0.1]. The patients with KCS and SS have also abnormal lacrimal tests (p < 0.01), and their epithelial cells presented squamous metaplasia (N/C, p < 0.001). The goblet cell number remained unchanged in the three groups (p > 0.1).
authors.affiliation: Department of Ophthalmology, University of Ioannina Medical School, Greece.
authors.forename: G
authors.initials: G
authors.lastname: Petroutsos
authors.forename: C A
authors.initials: CA
authors.lastname: Paschides
authors.forename: K X
authors.initials: KX
authors.lastname: Karakostas
authors.forename: K
authors.initials: K
authors.lastname: Psilas
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002452:Cell Count; D002648:Child; D003228:Conjunctiva / Q000473:pathology; D003584:Cytological Techniques; D015352:Dry Eye Syndromes / Q000175:diagnosis*; D005260:Female; D006801:Humans; D007638:Keratoconjunctivitis Sicca / Q000150:complications; D008297:Male; D008875:Middle Aged; D012395:Rose Bengal; D012859:Sjogren's Syndrome / Q000150:complications*
chemical_list: D012395:Rose Bengal