Correlation of in vitro and in vivo decreased fibrinolytic activity caused by dexamethasone.
The effect of dexamethasone administration to rats was studied on blood fibrinolytic activity. PAI-1 levels were dose-dependently enhanced by dexamethasone after a pretreatment period of 5 days while simultaneously a decreased tPA level was observed. These ex vivo measured effects were confirmed in vivo with a specially developed fibrinolysis model. It is concluded that the in vivo measured inhibition of the fibrinolytic activity caused by dexamethasone correlates well with ex vivo measured activities.
van Giezen
J J
JJ
Solvay Duphar B.V., Department of Vascular Pharmacology, DA Weesp, The Netherlands.
Jansen
J W
JW
D000818:Animals; D003907:Dexamethasone / Q000494:pharmacology*; D004591:Electrophoresis, Polyacrylamide Gel; D005342:Fibrinolysis / Q000187:drug effects*; D006801:Humans; D017395:Plasminogen Activator Inhibitor 1 / Q000097:blood*; D010960:Plasminogen Activators / Q000097:blood* / Q000302:isolation & purification; D051381:Rats; D012016:Reference Values; D010959:Tissue Plasminogen Activator / Q000097:blood* / Q000302:isolation & purification
D017395:Plasminogen Activator Inhibitor 1; D003907:Dexamethasone; D010960:Plasminogen Activators; D010959:Tissue Plasminogen Activator