Primary cutaneous aspergillosis in a heart transplant recipient treated with surgical excision and oral itraconazole.
A 24-year-old man underwent orthotopic heart transplantation for treatment of end-stage complex congenital heart disease. Six weeks postoperatively, five erythematous skin lesions developed on the patient's right forearm. Punch biopsy revealed Aspergillus. Despite extensive testing, no other potential primary site was located. Because of concern of dissemination, the patient was treated with a combination of local debridement and systemic antifungal therapy with itraconazole. He is presently without signs or symptoms of recurrent disease.
Loria
K M
KM
Division of Cardiology, Northwestern University Medical School, Evanston Hospital, Ill. 60201.
Salinger
M H
MH
Frohlich
T G
TG
Gendelman
M D
MD
Cook
F V
FV
Arentzen
C E
CE
D000328:Adult; D000935:Antifungal Agents / Q000627:therapeutic use*; D001228:Aspergillosis / Q000276:immunology / Q000628:therapy*; D003131:Combined Modality Therapy; D003646:Debridement; D003881:Dermatomycoses / Q000276:immunology / Q000628:therapy*; D016027:Heart Transplantation / Q000276:immunology*; D006801:Humans; D007165:Immunosuppression Therapy / Q000009:adverse effects; D017964:Itraconazole; D007654:Ketoconazole / Q000031:analogs & derivatives* / Q000627:therapeutic use; D008297:Male
D000935:Antifungal Agents; D017964:Itraconazole; D007654:Ketoconazole