title: Small hepatocellular carcinoma: diagnosis with US angiography with intraarterial CO2 microbubbles.
abstract: Ultrasonographic (US) angiography enhanced with intraarterial CO2 microbubbles, a contrast material used in US imaging, was performed of 103 histologically proved hepatocellular carcinomas (HCCs) smaller than 3 cm in diameter in 95 patients. The detection rate for hypervascular HCC with US angiography was compared with the rate of detection with conventional angiography, digital subtraction angiography (DSA), and computed tomography (CT) after intraarterial injection of iodized oil. Sensitivity in detection of hypervascular HCCs with US angiography was 86% (89 of 103 HCCs), compared with 63% (44 of 70 HCCs) detected with conventional angiography, 70% (23 of 33 HCCs) with DSA, and 82% (75 of 91 HCCs) with CT with iodized oil. US angiography depicted small hypervascular HCCs, especially those less than 1 cm in diameter, and helped clarify vascularity as isovascular or hypovascular in angiographically undetectable HCCs. Findings at US angiography assisted the choice of a therapeutic strategy for treatment of HCC, such as transarterial therapy, percutaneous ethanol injection therapy, or resection.
authors.affiliation: Department of Medicine, Kobe City General Hospital, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Kudo
authors.forename: S
authors.initials: S
authors.lastname: Tomita
authors.forename: H
authors.initials: H
authors.lastname: Tochio
authors.forename: J
authors.initials: J
authors.lastname: Mimura
authors.forename: Y
authors.initials: Y
authors.lastname: Okabe
authors.forename: H
authors.initials: H
authors.lastname: Kashida
authors.forename: M
authors.initials: M
authors.lastname: Hirasa
authors.forename: Y
authors.initials: Y
authors.lastname: Ibuki
authors.forename: A
authors.initials: A
authors.lastname: Todo
mesh_terms: D015901:Angiography, Digital Subtraction; D002245:Carbon Dioxide; D006528:Carcinoma, Hepatocellular / Q000098:blood supply / Q000000981:diagnostic imaging*; D005260:Female; D006801:Humans; D007459:Iodized Oil; D008113:Liver Neoplasms / Q000098:blood supply / Q000000981:diagnostic imaging*; D008297:Male; D008875:Middle Aged; D012680:Sensitivity and Specificity; D014057:Tomography, X-Ray Computed; D014463:Ultrasonography / Q000379:methods
chemical_list: D002245:Carbon Dioxide; D007459:Iodized Oil