[State of the free-radical oxidation system in normobaric hypoxia].
The experiments on the rats have revealed that 7-hour action of 10% hypoxic gas mixture (HGM-10) exerts no effect on the parameters of Fe(2+)-induced chemiluminescence and rate of accumulation of TBA-active products in the heart, liver, kidney, brain tissues and blood plasma. Two-week adaptation to intermittent effect of HGM-10 causes some activation of free-radical oxidation recorded in blood plasma and the more pronounced increase in power of the endogenic antioxidant system. It is assumed that the revealed changes in the state of the homeostatic system of free-radical oxidation and antiradical protection of the organism are of importance in the mechanism of the known preventive and curative action of intermittent normobaric hypoxia.
Belykh
A G
AG
Gukasov
V M
VM
Chukaev
S A
SA
D000222:Adaptation, Physiological / Q000187:drug effects; D000818:Animals; D005609:Free Radicals; D000860:Hypoxia / Q000378:metabolism* / Q000503:physiopathology; D015227:Lipid Peroxidation / Q000187:drug effects; D010100:Oxygen / Q000494:pharmacology; D051381:Rats; D013997:Time Factors
D005609:Free Radicals; D010100:Oxygen
Sostoianie sistemy svobodnoradikalńogo okisleniia pri deĭstvii normobaricheskoĭ gipoksii.