[Rearrangement of the bcl1 and bcl2 oncogenes in chronic lymphoid leukemia].
Oncogenes bcl1 and bcl2 are located in the rupture site of t(11;14) and t(14; 18), respectively. They have been found to rearrange in different B-cell malignancies. A molecular study of oncogenes bcl1 and bcl2 was carried out in 42 patients diagnosed of B-cell chronic lymphoid leukaemia. In 14.3% of the patients the rearrangement affected bcl1, but no differences were found with regard to stage and clinical course between these patients and those without any oncogen rearrangement. In all the patients studied bc12 was in a germinal configuration.
Aláez
C
C
Instituto de Hematología e Inmunología, Ciudad de La Habana, Cuba.
Corral
L
L
Hernández Hernández
A
A
Muñiz
A
A
Cruz
C
C
Fernández
O
O
Hernández Ramírez
P
P
Martínez
G
G
D000368:Aged; D000369:Aged, 80 and over; D015139:Blotting, Southern; D002883:Chromosomes, Human, Pair 14 / Q000648:ultrastructure*; D002887:Chromosomes, Human, Pair 18 / Q000648:ultrastructure*; D004273:DNA, Neoplasm / Q000032:analysis; D005260:Female; D015321:Gene Rearrangement; D006801:Humans; D016130:Immunophenotyping; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D009857:Oncogenes; D014178:Translocation, Genetic
D004273:DNA, Neoplasm
Reordenamiento de los oncogenes bcl1 y bcl2 en la leucemia linfoide crónica.