[Inhibitors of angiotensin-converting enzyme and processus of intima proliferation in atherosclerosis].
The renin angiotensin system is a negative feed-back system of blood pressure control. A number of concordant experimental and clinical results indicate that the angiotensin family has a trophic effect on the vessel wall. These properties of the angiotensins favorise the proliferation of the cells which make up the vessel wall and also amplify the vascular dysfunction in the absence of the inhibitory regulations. Angiotensin converting enzyme inhibitors could be a valuable therapeutic method of counteracting these deleterious effects on the composition and function of the vessel wall.
Rolland
P H
PH
INSERM U-278, Laboratoire de chimie biologique, Faculté de pharmacie, Marseille.
Friggi
A
A
Bodard
H
H
Garçon
D
D
Charpiot
P
P
Barlatier
A
A
Calaf
R
R
Faye
M M
MM
Mercier
C
C
Luccioni
R
R
D000806:Angiotensin-Converting Enzyme Inhibitors / Q000494:pharmacology* / Q000627:therapeutic use; D000818:Animals; D001161:Arteriosclerosis / Q000473:pathology / Q000517:prevention & control*; D002455:Cell Division; D005260:Female; D006801:Humans; D008297:Male; D011817:Rabbits; D012306:Risk; D017539:Tunica Intima / Q000166:cytology / Q000187:drug effects*
D000806:Angiotensin-Converting Enzyme Inhibitors
Les inhibiteurs de l'enzyme de conversion de l'angiotensine et les processus de prolifération intimale dans l'athérosclérose.