[Circulating immune complexes and complement fragment iC3b in chronic polyarthritis during 12 months therapy with oral enzymes in comparison with oral gold].
In the course of a double-blind randomized study lasting 1 year 19 patients suffering from ensured rheumatoid arthritis (ARA criteria) were treated with oral hydrolytic enzymes or oral gold salts. The effects of these therapies were examined in regard to changes in serum concentrations of circulating immune complexes (CIC) and the complement component iC3b. After 12 months treatment with oral enzymes we determined a therapeutically wanted significant decrease of CIC whereas CIC increased up to 6 months. The best but not significant result under therapy with oral gold salts concerning CIC was a decrease in 6 out of 9 patients after 9 months. The complement component iC3b diminished with either therapy during the first 6 months and increased afterwards. As well as the reduction of circulating immune complexes, the intensified inactivation of C3b into iC3b during the second half-year with both treatments indicates that there might be a slight improvement of the pathologically changed immunoreactions after 6 months only. Concerning the examined laboratory parameters, no significant difference was found between both therapies.
Kullich
W
W
Ludwig-Boltzmann-Institut für Rehabilitation interner Erkrankungen, Saalfelden.
Schwann
H
H
D000936:Antigen-Antibody Complex / Q000032:analysis*; D001172:Arthritis, Rheumatoid / Q000188:drug therapy* / Q000276:immunology; D001310:Auranofin / Q000008:administration & dosage*; D003179:Complement C3b / Q000032:analysis*; D004311:Double-Blind Method; D004338:Drug Combinations; D005260:Female; D006801:Humans; D006867:Hydrolases / Q000008:administration & dosage*; D008297:Male; D008875:Middle Aged; D012431:Rutin / Q000008:administration & dosage*
D000936:Antigen-Antibody Complex; D004338:Drug Combinations; D001310:Auranofin; D012431:Rutin; C023295:Wobenzym; D003179:Complement C3b; D006867:Hydrolases
Zirkulierende Immunkomplexe und das Komplementfragment iC3b bei chronischer Polyarthritis während einer 12monatigen Therapie mit oralen Enzymen im Vergleich zu oralem Gold.