title: [Use of immunosorption for selective decrease of lipoprotein (A) levels in patients with coronary atherosclerosis].
abstract: Lipoprotein (a) [L(a)] is an atherogenic lipoprotein, its human plasma concentration correlates with the occurrence of coronary heart disease. The procedure for selectively removing L(a) with an anti-L(a) immunosorbent was performed to treat 3 patients who had high L(a), normal total cholesterol and other lipoprotein levels. All the patients had coronary stenosis as documented by angiography. After L(a)-apheresis, the level of L(a) decreased by 72%, while that of other plasma components, including low density lipoproteins virtually unchanged. Thus, the procedure of L(a)-apheresis is an effective and safe method for lowering human blood L(a) concentrations. In addition, this in vivo model allows information on L(a) metabolism to be obtained.
authors.forename: A V
authors.initials: AV
authors.lastname: Susekov
authors.forename: O I
authors.initials: OI
authors.lastname: Afanaséva
authors.forename: I Iu
authors.initials: IIu
authors.lastname: Adamova
authors.forename: A A
authors.initials: AA
authors.lastname: Liakishev
authors.forename: V V
authors.initials: VV
authors.lastname: Kukharchuk
authors.forename: S N
authors.initials: SN
authors.lastname: Pokrovskiĭ
mesh_terms: D000328:Adult; D003324:Coronary Artery Disease / Q000097:blood* / Q000175:diagnosis / Q000628:therapy*; D015716:Electrocardiography, Ambulatory; D006801:Humans; D007163:Immunosorbent Techniques; D017270:Lipoprotein(a) / Q000097:blood*; D008297:Male; D008875:Middle Aged; D010956:Plasmapheresis / Q000379:methods
chemical_list: D017270:Lipoprotein(a)
vernacular_title: Primenenie immunosorbtsii dlia selektivnogo snizheniia urovnia lipoproteida (a) u bolńykh aterosclerozom.