G-CSF mobilised progenitor cells in autologous transplantation: in vitro and in vivo aspects.
G-CSF administration leads to significant elevation in the levels of circulating progenitor cells. Infusion of these cells after high-dose chemotherapy is associated with accelerated platelet engraftment that has a considerable impact in shortening thrombocytopenia and reducing need for platelet transfusions.
Begley
C G
CG
The Royal Melbourne Hospital, Victoria, Australia.
DeLuca
E
E
Rowlings
P A
PA
Szer
J
J
Watson
D
D
Juttner
C
C
Morstyn
G
G
Fox
R M
RM
Sheridan
W
W
D000328:Adult; D000970:Antineoplastic Agents / Q000009:adverse effects*; D016913:Blood Component Transfusion / Q000379:methods*; D016026:Bone Marrow Transplantation / Q000009:adverse effects*; D002478:Cells, Cultured; D003114:Colony-Forming Units Assay; D016179:Granulocyte Colony-Stimulating Factor / Q000627:therapeutic use*; D006412:Hematopoietic Stem Cells / Q000187:drug effects*; D006801:Humans; D008875:Middle Aged; D012307:Risk Factors; D013921:Thrombocytopenia / Q000188:drug therapy; D014182:Transplantation, Autologous
D000970:Antineoplastic Agents; D016179:Granulocyte Colony-Stimulating Factor