Obesity and hypertension: experimental data.
BACKGROUND TO DATA REVIEW: Epidemiologic surveys have demonstrated that hypertension is associated with obesity in a substantial proportion of cases, particularly in young and middle-aged adults. Despite the clinical importance of this association the nature of the relationship between body weight and blood pressure remains obscure. CONCLUSION OF DATA REVIEW: The data reviewed here indicate that obesity-related hypertension involves insulin and the sympathetic nervous system, and may be part of a metabolic adaptation to the obese state.
Landsberg
L
L
Department of Medicine, Northwestern University Medical School, Chicago, Illinois.
D000222:Adaptation, Physiological / Q000502:physiology; D000818:Animals; D001794:Blood Pressure / Q000502:physiology*; D005260:Female; D006801:Humans; D006973:Hypertension / Q000453:epidemiology* / Q000209:etiology; D007328:Insulin / Q000502:physiology; D007333:Insulin Resistance / Q000502:physiology; D008297:Male; D009638:Norepinephrine / Q000502:physiology; D009765:Obesity / Q000150:complications / Q000453:epidemiology*; D015995:Prevalence; D013564:Sympathetic Nervous System / Q000502:physiology
D007328:Insulin; D009638:Norepinephrine