title: Human immunodeficiency virus in gestational trophoblastic neoplasias--is it a poor prognostic risk factor.
abstract: Three cases of HIV infection with choriocarcinoma are presented. One case had prolonged chemotherapy without remission, the second had remission only after combining hysterectomy with chemotherapy and the third who had extensively metastatic disease in the presence of other low risk factors are reported. HIV infection may predispose patients to extensive metastatic choriocarcinoma and influence the course of treatment. We propose that HIV infection be considered a poor prognostic risk for gestation trophoblastic neoplasias.
authors.affiliation: Department of Obstetric and Gynaecology, Faculty of Medicine, College of Health Sciences, University of Nairobi, Kenya.
authors.forename: S B
authors.initials: SB
authors.lastname: Ojwang
authors.forename: M R
authors.initials: MR
authors.lastname: Otieno
authors.forename: K S
authors.initials: KS
authors.lastname: Khan
mesh_terms: D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D015153:Blotting, Western; D002822:Choriocarcinoma / Q000150:complications* / Q000175:diagnosis / Q000628:therapy; D006063:Chorionic Gonadotropin / Q000652:urine; D018997:Chorionic Gonadotropin, beta Subunit, Human; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D015658:HIV Infections / Q000150:complications* / Q000175:diagnosis; D015497:HIV-1; D006801:Humans; D007044:Hysterectomy; D010446:Peptide Fragments / Q000652:urine; D011247:Pregnancy; D011379:Prognosis; D016216:Ultrasonography, Prenatal; D014594:Uterine Neoplasms / Q000150:complications* / Q000175:diagnosis / Q000628:therapy
chemical_list: D006063:Chorionic Gonadotropin; D018997:Chorionic Gonadotropin, beta Subunit, Human; D010446:Peptide Fragments