title: [The interrelation of the antimutagenic action of mannitol to its effect on cellular metabolic processes].
abstract: The mannitol influence on mutagenesis of ionizing radiation and cyclophosphate has been studied in albino mongrel rats using the methods of genetic and biochemical analysis. N correlation is determined between antimutagenic action of this preparation and a decrease of malondialdehyde content in cells and free fractions of matrix lysosomes (beta-galactosidase; N-acetyl-beta-D-glucosaminidase) and firmly membrane-structurized microsomal (glucose-6-phosphatase) enzymes, whose level increases under the influence of mutagens. It is shown that, one of the way of antimutagenic actions of mannitol is connected with mutagenesis correction at the stage of origin of mutagenic products and their transport to chromosome DNA.
authors.forename: A A
authors.initials: AA
authors.lastname: Aliev
authors.forename: G K
authors.initials: GK
authors.lastname: Ragimova
authors.forename: R R
authors.initials: RR
authors.lastname: Gadzhiev
authors.forename: U K
authors.initials: UK
authors.lastname: Alekperov
mesh_terms: D000818:Animals; D016587:Antimutagenic Agents / Q000494:pharmacology*; D002869:Chromosome Aberrations; D003520:Cyclophosphamide / Q000494:pharmacology; D015227:Lipid Peroxidation / Q000187:drug effects / Q000528:radiation effects; D008353:Mannitol / Q000494:pharmacology*; D016296:Mutagenesis / Q000187:drug effects / Q000502:physiology / Q000528:radiation effects; D051381:Rats; D014916:Whole-Body Irradiation
chemical_list: D016587:Antimutagenic Agents; D008353:Mannitol; D003520:Cyclophosphamide
vernacular_title: Vzaimosviaz' antimutagennogo deĭstviia mannita s ego vliianiem na nekotorye protsessy klletochnogo metabolizma.