Mechanisms of local, low-dose UVB-induced immunosuppression in contact hypersensitivity.
Preirradiation of contact sensitizing sites to low-dose ultraviolet B (UVB) renders animals unresponsive to challenge reaction. This unresponsiveness is known as local, low-dose UVB-induced immunosuppression. Although researchers in this area have developed theories, the exact mechanisms of UVB-induced immunosuppression are still a matter of controversy. This article reviewed various scientific data on UVB-induced immunosuppression, categorizing them into individual sequential steps in the whole cascade.
Tokura
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Department of Dermatology, Hamamatsu University School of Medicine, Japan.
D000818:Animals; D003877:Dermatitis, Contact / Q000276:immunology* / Q000503:physiopathology; D006801:Humans; D007108:Immune Tolerance / Q000528:radiation effects*; D015603:Keratinocytes / Q000378:metabolism; D007801:Langerhans Cells / Q000378:metabolism; D014466:Ultraviolet Rays