[The effect of trental and actovegin on the organs of vision when administered into the end periorbital branches of the ophthalmic artery (experimental research)].
Specific features of the delivery and the possible side affects of intraarterial infusions of trental and actovegin on the retina, vessels, and the optic nerve in administration of these drugs into the peripheral periorbital branches of the orbital artery were under study. Contrast angiography and fluorescent angiography have confirmed in all the cases the correctness of the catheter position and its functional competence, as well as the possibility of rapidly creating the necessary concentration of the drugs in the retinal and choroidal vessels for a sufficiently long time. Electroretinogram recording before and after intraarterial infusions of the before drugs has demonstrated the functional intactness of the retina, and morphologic studies have shown the absence of any injurious effect of the drug on the organ of vision in such a method of administration. Results of experimental trials permit recommending starting the clinical trials of the intraarterial infusion of trental and actovegin into the periorbital branches of the orbital artery.
Baiandin
D L
DL
Eremin
D A
DA
Pereverzina
O K
OK
Fedorov
A A
AA
D000818:Animals; D004285:Dogs; D006418:Heme / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000494:pharmacology; D007269:Injections, Intra-Arterial; D009880:Ophthalmic Artery; D009900:Optic Nerve / Q000187:drug effects*; D009915:Orbit / Q000098:blood supply*; D010431:Pentoxifylline / Q000008:administration & dosage / Q000494:pharmacology*; D012160:Retina / Q000187:drug effects*; D014602:Uvea / Q000187:drug effects*
D006418:Heme; C015646:Actovegin; D010431:Pentoxifylline
Vliianie trentala i aktovegina na organy zreniia pri vvedenii ikh v kontsevye periorbital'nye vetvi glaznichnoĭ arterii (éksperimental'noe issledovanie).