[Cytotoxic response against human immunodeficiency virus (HIV): control with suppressor factor].
We report a new suppressor function of CD8+ CD57+ lymphocytes from HIV-seropositive patients recipients, on the cytolytic activity of allospecific CTL, NK and LAK cells. This inhibitory effect is mediated by a non-antigen specific soluble factor distinct from PGE2, TGF beta and TNF alpha and beta. Biochemical characterization indicates that the CD8+ CD57+ inhibitory activity: 1) is heat and trypsin resistant but remains sensitive to pronase E hydrolyse, 2) specifically bind to concanavalin A-sepharose column, 3) is mediated by a 20-30 kdaltons glycoprotein.
Sadat-Sowti
B
B
Laboratoire d'Immunologie tissulaire et cellulaire, CERVI, Paris.
Debré
P
P
Autran
B
B
D055598:Chemical Phenomena; D002627:Chemistry, Physical; D003602:Cytotoxicity, Immunologic / Q000187:drug effects*; D006678:HIV / Q000187:drug effects*; D013491:Suppressor Factors, Immunologic / Q000737:chemistry / Q000494:pharmacology*; D050378:T-Lymphocytes, Regulatory / Q000737:chemistry*
D013491:Suppressor Factors, Immunologic
Réponse cytotoxique contre le virus de l'immunodéficience humaine (VIH): contrôle par un facteur suppresseur.