Modification of radiation-induced carcinogenesis in mice by misonidazole and WR-2721.
The effects of the radiosensitizer misonidazole (MISO) and the radioprotector WR-2721 on radiation-induced carcinogenesis in C3Hf/Kam mice were investigated. The right hind legs were exposed to graded single doses of gamma-rays. MISO and WR-2721 were given i.p. 30 min before irradiation at a dose of 1 mg/g and 0.4 mg/g, respectively. The RCD50, or radiation dose inducing tumors in 50% of the irradiated legs, was determined 650 days after treatment. The same animals were also checked for the effect of these drugs on hair loss and radiation-induced leg contractures. MISO enhanced radiation carcinogenesis by a factor of 1.43, whereas WR-2721 reduced it by a factor of 1.75. These effects on carcinogenesis correlated well with the modifying effects of the two agents on radiation-induced hair loss (early damage) and leg contractures (late damage).
Hunter
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Department of Experimental Radiotherapy, University of Texas M. D. Anderson Cancer Center, Houston 77030.
Guttenberger
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R
Milas
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L
D004999:Amifostine / Q000494:pharmacology*; D000818:Animals; D003286:Contracture / Q000209:etiology; D003864:Depression, Chemical; D006197:Hair / Q000528:radiation effects; D006614:Hindlimb / Q000528:radiation effects; D008297:Male; D051379:Mice; D008809:Mice, Inbred C3H; D008920:Misonidazole / Q000494:pharmacology*; D009381:Neoplasms, Radiation-Induced / Q000503:physiopathology*; D013268:Stimulation, Chemical
D008920:Misonidazole; D004999:Amifostine