Praxilene (naftidrofuryl oxalate) as an alternative for the augmentation of femoro-distal bypass blood flow.
In 30 patients undergoing femoro-distal bypass the effect of papaverine and praxilene on blood flow in the graft was measured. The mean resting flow was 129 ml min-1 (range: 91-167) and after papaverine was 202 ml min-1 (142-262) and after praxilene was 205 ml min-1 (143-267). Praxilene has a similar effect to papaverine in the augmentation of blood flow, and further investigation is needed to see if long-term praxilene administration might improve graft survival.
Davies
A H
AH
Department of Vascular Studies, Bristol Royal Infirmary, U.K.
Magee
T R
TR
Baird
R N
RN
Horrocks
M
M
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001783:Blood Flow Velocity / Q000187:drug effects; D005263:Femoral Artery / Q000000981:diagnostic imaging / Q000601:surgery*; D006801:Humans; D007511:Ischemia / Q000000981:diagnostic imaging / Q000601:surgery*; D007866:Leg / Q000098:blood supply*; D008875:Middle Aged; D016343:Monitoring, Intraoperative / Q000295:instrumentation; D009257:Nafronyl / Q000008:administration & dosage*; D010208:Papaverine / Q000008:administration & dosage*; D012501:Saphenous Vein / Q000637:transplantation*; D014463:Ultrasonography / Q000295:instrumentation
D009257:Nafronyl; D010208:Papaverine