title: [Cardiovascular complications of interferon].
abstract: Interferon, a fairly recent drug, is used in some cancers and other diseases. The adverse effects include cardiotoxicity which was recognized from phase-I trials. Some of these complications are very common and not serious at the dose levels administered: transient hypotension at the beginning of the treatment, atrial extrasystole. Other effects are less common and not dangerous: low-level conduction impairment or reversible hypertension as the authors recalled. There are also a much more serious forms of toxicity which may be life-threatening, one of which seems to be dose-dependent and consists of the onset of cardiomyopathy, which is usually reversible when treatment is stopped, the other is uncontrollable and usually occurs in high-risk cardiac patients from the first few injections and results in sudden death induced by acute coronary artery failure and/or serious ventricular arrhythmia. The physiopathology of this cardiotoxicity remains unknown, but as it is known to exist, rigorous cardiological monitoring of all patients receiving this treatment is necessary.
authors.affiliation: Service de Cardiologie, Hôpital Pasteur, Nice.
authors.forename: E
authors.initials: E
authors.lastname: Ferrari
authors.forename: B
authors.initials: B
authors.lastname: Taillan
authors.forename: P
authors.initials: P
authors.lastname: Gibelin
authors.forename: J G
authors.initials: JG
authors.lastname: Fuzibet
authors.forename: P
authors.initials: P
authors.lastname: Dujardin
authors.forename: M
authors.initials: M
authors.lastname: Baudouy
authors.forename: P
authors.initials: P
authors.lastname: Morand
mesh_terms: D000368:Aged; D006331:Heart Diseases / Q000139:chemically induced* / Q000503:physiopathology; D006801:Humans; D006973:Hypertension / Q000139:chemically induced; D007372:Interferons / Q000009:adverse effects*; D008297:Male
chemical_list: D007372:Interferons
vernacular_title: Les complications cardiovasculaires de l'interféron.