title: [The individual characteristics of the activity of the DNA-repair enzyme O(6)-alkylguanine-DNA alkyltransferase in the stomach of monkeys exposed to the gastric carcinogen N-ethyl-N1-nitro-N-nitrosoguanidine].
abstract: Variations in the activity of a DNA repair enzyme 0(6)-alkylgianine-DNA alkyltransferase (AGT) were studied in gastric mucosa samples obtained from 15 M. fascicularis monkeys chronically exposed to a gastrocarcinogen N-ethyl-N'-nitro-N-nitrosoguanidine. Marked interindividual difference in the enzyme activity before and in the course of the exposure was observed. The value of AGT activity assay to predict individual susceptibility to alkylating carcinogens is discussed.
authors.forename: N A
authors.initials: NA
authors.lastname: Loktionova
authors.forename: D Sh
authors.initials: DSh
authors.lastname: Beniashvili
authors.forename: M A
authors.initials: MA
authors.lastname: Zabezhinskiĭ
authors.forename: O I
authors.initials: OI
authors.lastname: Kazanova
authors.forename: A S
authors.initials: AS
authors.lastname: Petrov
authors.forename: A Ia
authors.initials: AIa
authors.lastname: Likhachev
mesh_terms: D000818:Animals; D001706:Biopsy; D002273:Carcinogens / Q000633:toxicity*; D004260:DNA Repair / Q000187:drug effects*; D005260:Female; D005753:Gastric Mucosa / Q000187:drug effects* / Q000201:enzymology / Q000473:pathology; D007962:Leukocytes / Q000187:drug effects / Q000201:enzymology; D008252:Macaca fascicularis; D008297:Male; D008769:Methylnitronitrosoguanidine / Q000031:analogs & derivatives* / Q000633:toxicity; D008780:Methyltransferases / Q000187:drug effects* / Q000378:metabolism; D019853:O(6)-Methylguanine-DNA Methyltransferase; D013274:Stomach Neoplasms / Q000139:chemically induced / Q000201:enzymology / Q000473:pathology; D013997:Time Factors
chemical_list: D002273:Carcinogens; D008769:Methylnitronitrosoguanidine; C013525:ENNG; D008780:Methyltransferases; D019853:O(6)-Methylguanine-DNA Methyltransferase
vernacular_title: Individual'nye osobennosti aktivnosti fermenta reparatsii DNK O(6)-alkilguanin-DNK alkiltransferazy zheludka obez'ian, podvergnutykh vozdeĭstviiu gastrokantserogena N-étil-N1-nitro-N-nitrozoguanidina.