Genetic dissection of autoimmune type I diabetes in the BB rat.
The BB rat is among the best models of insulin-dependent diabetes mellitus--with onset and pathogenesis closely resembling the human disease. One unusual feature is a severe T-cell lymphopenia, which appears to be inherited as a recessive trait controlled by a single gene, Lyp. Based on genetic analysis of several crosses, we show that development of diabetes involves at least three genes: Lyp, which is tightly linked to the neuropeptide Y (Npy) gene on chromosome 4, a gene linked to the major histocompatibility complex (MHC) on chromosome 20, and a third unmapped gene for which the Fischer rat strain carries an allele conferring resistance.
Jacob
H J
HJ
Whitehead Institute for Biomedical Research, Cambridge, Massachusetts 02142.
Pettersson
A
A
Wilson
D
D
Mao
Y
Y
Lernmark
A
A
Lander
E S
ES
D000818:Animals; D001483:Base Sequence; D002874:Chromosome Mapping; D003433:Crosses, Genetic; D004247:DNA / Q000235:genetics; D003922:Diabetes Mellitus, Type 1 / Q000235:genetics*; D005260:Female; D005808:Genes, Recessive; D008040:Genetic Linkage; D005819:Genetic Markers; D008231:Lymphopenia / Q000235:genetics; D008285:Major Histocompatibility Complex; D008297:Male; D008969:Molecular Sequence Data; D009478:Neuropeptide Y / Q000235:genetics; D051381:Rats; D011913:Rats, Inbred BB; D011916:Rats, Inbred F344; D011917:Rats, Inbred Lew; D013601:T-Lymphocytes
D005819:Genetic Markers; D009478:Neuropeptide Y; D004247:DNA