title: A family of metabotropic glutamate receptors.
abstract: Three cDNA clones, mGluR2, mGluR3, and mGluR4, were isolated from a rat brain cDNA library by cross-hybridization with the cDNA for a metabotropic glutamate receptor (mGluR1). The cloned receptors show considerable sequence similarity with mGluR1 and possess a large extracellular domain preceding the seven putative membrane-spanning segments. mGluR2 is expressed in some particular neuronal cells different from those expressing mGluR1 and mediates an efficient inhibition of forskolin-stimulated cAMP formation in cDNA-transfected cells. The mGluRs thus form a novel family of G protein-coupled receptors that differ in their signal transduction and expression patterns.
authors.affiliation: Institute for Immunology, Kyoto University Faculty of Medicine, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Tanabe
authors.forename: M
authors.initials: M
authors.lastname: Masu
authors.forename: T
authors.initials: T
authors.lastname: Ishii
authors.forename: R
authors.initials: R
authors.lastname: Shigemoto
authors.forename: S
authors.initials: S
authors.lastname: Nakanishi
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D001923:Brain Chemistry; D016466:CHO Cells; D002462:Cell Membrane / Q000737:chemistry; D002531:Cerebellum / Q000737:chemistry; D002540:Cerebral Cortex / Q000737:chemistry; D003001:Cloning, Molecular; D005576:Colforsin / Q000494:pharmacology; D006224:Cricetinae; D000242:Cyclic AMP / Q000096:biosynthesis; D004247:DNA / Q000737:chemistry / Q000302:isolation & purification; D015870:Gene Expression; D008969:Molecular Sequence Data; D009693:Nucleic Acid Hybridization; D009830:Olfactory Bulb / Q000737:chemistry; D012333:RNA, Messenger / Q000032:analysis; D051381:Rats; D017470:Receptors, Glutamate; D017981:Receptors, Neurotransmitter / Q000737:chemistry / Q000235:genetics*; D015398:Signal Transduction; D014018:Tissue Distribution; D014162:Transfection
chemical_list: D012333:RNA, Messenger; D017470:Receptors, Glutamate; D017981:Receptors, Neurotransmitter; D005576:Colforsin; D004247:DNA; D000242:Cyclic AMP