Synthesis and anti-inflammatory activity of 2-pyridyl-2-thiobenzothiazole derivatives.
A series of novel 2-pyridyl-2-thiobenzothiazole compounds was prepared and investigated by a number of in vitro methods in order to determine their anti-inflammatory properties. Results are discussed with reference to well known NSAIDs. (3-carboxy-2-pyridyl)-2-thiobenzothiazole had the most potent anti-inflammatory activity, being 1.34 times more active than indomethacin used as reference compound.
Lagorce
J F
JF
Department of Therapeutic and Organic Chemistry, Faculty of Pharmacy, University of Limoges, France.
Lakhdar
M
M
Fatimi
J
J
Nefaoui
S
S
Raby
C
C
D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000138:chemical synthesis* / Q000494:pharmacology; D002351:Carrageenan; D002417:Cattle; D015232:Dinoprostone / Q000096:biosynthesis / Q000097:blood; D004487:Edema / Q000139:chemically induced / Q000517:prevention & control; D005609:Free Radicals / Q000378:metabolism; D006801:Humans; D066298:In Vitro Techniques; D007213:Indomethacin / Q000494:pharmacology; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D013582:Synovial Fluid / Q000187:drug effects / Q000378:metabolism; D013844:Thiazoles / Q000138:chemical synthesis* / Q000494:pharmacology
D000894:Anti-Inflammatory Agents, Non-Steroidal; D005609:Free Radicals; D013844:Thiazoles; D002351:Carrageenan; D015232:Dinoprostone; D007213:Indomethacin