Possible contribution of free radicals and lipid peroxidations on pathogenesis of post-ischemic brain damage.
It has been widely accepted concept that peroxidate decomposition of membrane lipids contribute cellular damage in cerebral ischemia, and varieties of putative cascading reactions has been proposed in this regard as the underlying detrimental processes. But little is known about existence and significance of the blood born chemical mediator. In this communication, the authors tried to emphasize the prospective role of leukocyte invasion to the ischemic brain tissue. Effectiveness of some clinically applicable antioxidants against ischemic brain damage was also discussed.
Yamasaki
Y
Y
Department of Neurology, Tohoku University School of Medicine.
Kogure
K
K
D000975:Antioxidants / Q000627:therapeutic use; D001930:Brain Injuries / Q000150:complications / Q000378:metabolism; D002545:Brain Ischemia / Q000209:etiology / Q000378:metabolism* / Q000473:pathology; D016166:Free Radical Scavengers; D005609:Free Radicals; D006801:Humans; D007962:Leukocytes / Q000378:metabolism; D015227:Lipid Peroxidation; D017382:Reactive Oxygen Species / Q000378:metabolism*
D000975:Antioxidants; D016166:Free Radical Scavengers; D005609:Free Radicals; D017382:Reactive Oxygen Species