title: [The effect of ziksorin on the development of experimental food anaphylaxis in guinea pigs].
abstract: A study was made of the effect of zixorin, an inductor of liver cytochrome P-450, on the intensity of the immediate type allergic reaction--active food anaphylaxis in response to ovalbumin in guinea-pigs. Intraperitoneal injection of zixorin in a dose of 50 mg/kh for 3 days before administration of the antigen resolution dose was found to lower 2,3-fold the level of lethal outcomes due to the anaphylactic shock. It is suggested that zixorin may be used in multimodality treatment of food allergy.
authors.forename: T G
authors.initials: TG
authors.lastname: Khlopushina
authors.forename: A V
authors.initials: AV
authors.lastname: Krinskaia
authors.forename: L P
authors.initials: LP
authors.lastname: Kovalenko
authors.forename: B I
authors.initials: BI
authors.lastname: Liubimov
mesh_terms: D000276:Adjuvants, Immunologic / Q000627:therapeutic use*; D000707:Anaphylaxis / Q000209:etiology / Q000517:prevention & control*; D000818:Animals; D001559:Benzhydryl Compounds / Q000627:therapeutic use*; D003577:Cytochrome P-450 Enzyme System / Q000096:biosynthesis / Q000187:drug effects; D004353:Drug Evaluation, Preclinical; D004527:Egg Proteins / Q000009:adverse effects*; D004790:Enzyme Induction / Q000187:drug effects; D005512:Food Hypersensitivity / Q000209:etiology / Q000517:prevention & control*; D006168:Guinea Pigs; D006969:Hypersensitivity, Immediate / Q000209:etiology / Q000517:prevention & control; D007114:Immunization; D008297:Male
chemical_list: D000276:Adjuvants, Immunologic; D001559:Benzhydryl Compounds; D004527:Egg Proteins; D003577:Cytochrome P-450 Enzyme System; C016914:flumecinol
vernacular_title: Vliianie ziksorina na razvitie éksperimental'noĭ pishchevoĭ anafilaksii u morskikh svinok.