Substance P as a potent stimulator of sneeze responses in experimental allergic rhinitis of guinea pigs.
Substance P was examined for sneeze-inducing activity and its involvement of sneeze responses in experimental allergic rhinitis. Substance P, dripped into a nostril of guinea pigs, at concentrations of 100 pM and above induced sneezing in a dose-dependent fashion. The activity of substance P was not affected by the previous subcutaneous injections of capsaicin that depleted substance P in nerve fibers. Histamine induced sneezing at concentrations of 30 mM and above and the activity was reduced by capsaicin treatment. The frequency of antigen-induced sneezing was proportional to the substance P content in nasal mucosa of sensitized guinea pigs treated with increasing doses of capsaicin; correlation coefficient 0.91. These results suggest that substance P plays an important role as a stimulator of sneeze responses in experimental allergic rhinitis in guinea pigs.
Imamura
T
T
Department of Neuroscience and Immunology, Kumamoto University Graduate School of Medical Sciences, Japan.
Kambara
T
T
D000818:Animals; D001200:Ascaris / Q000276:immunology; D002211:Capsaicin / Q000494:pharmacology; D006168:Guinea Pigs; D006632:Histamine / Q000494:pharmacology; D009297:Nasal Mucosa / Q000378:metabolism; D006255:Rhinitis, Allergic, Seasonal / Q000503:physiopathology*; D012912:Sneezing / Q000187:drug effects*; D013373:Substance P / Q000378:metabolism / Q000494:pharmacology*
D013373:Substance P; D006632:Histamine; D002211:Capsaicin