[Protective action of seed oil of Hippophae rhamnoides L. (HR) against experimental liver injury in mice].
Protection by seed oil of HR against hepatic injury induced by CCl4, ethyl alcohol and acetaminophen (AAP) on mice was studied in this paper. It was found that seed oil of HR markedly inhibited MDA formation of liver induced by CCl4, AAP and ethyl alcohol, seed oil 4.75 g/kg could lower SGPT levels induced by CCl4 and AAP. It blocked also depletion of GSH damaged liver induced by AAP. The mechanism of heptoprotective actions of HR seed oil might be related to anti-lipid peroxidation.
Cheng
T J
TJ
Department of Pharmacology, Lanzhou Medical College.
D000082:Acetaminophen; D000410:Alanine Transaminase / Q000097:blood; D000818:Animals; D002252:Carbon Tetrachloride Poisoning / Q000378:metabolism / Q000517:prevention & control; D056486:Chemical and Drug Induced Liver Injury / Q000209:etiology / Q000378:metabolism / Q000517:prevention & control*; D005978:Glutathione / Q000378:metabolism; D006519:Hepatitis, Alcoholic / Q000209:etiology / Q000378:metabolism / Q000517:prevention & control*; D008297:Male; D008315:Malondialdehyde / Q000378:metabolism; D051379:Mice; D010938:Plant Oils / Q000627:therapeutic use*
D010938:Plant Oils; D000082:Acetaminophen; D008315:Malondialdehyde; D000410:Alanine Transaminase; D005978:Glutathione