title: I-123 iofetamine SPECT scan in systemic lupus erythematosus patients with cognitive and other minor neuropsychiatric symptoms: a pilot study.
abstract: Accurate diagnosis of central nervous system (CNS) lupus remains difficult, especially when the manifestations are of subtle cognitive and affective changes. This pilot study reports on the use of I-123 iofetamine single photon emission computerized tomography (SPECT) scans in 18 such patients with documented systemic lupus erythematosus. Eight of the 18 scans were abnormal (44%), four in a diffuse bi-temporo-parietal pattern previously noted only in Alzheimer's disease, and four with large focal deficits. Neither the existence of the abnormal scan nor the particular pattern of abnormality correlated with the results of other diagnostic tests. These preliminary results raise the possibility that SPECT scans may offer an additional valuable diagnostic instrument in CNS lupus, although further studies are necessary to delineate their precise role.
authors.affiliation: Department of Medicine, Brigham and Women's Hospital, Boston, Massachusetts 02115.
authors.forename: M P
authors.initials: MP
authors.lastname: Rogers
authors.forename: E
authors.initials: E
authors.lastname: Waterhouse
authors.forename: J S
authors.initials: JS
authors.lastname: Nagel
authors.forename: N W
authors.initials: NW
authors.lastname: Roberts
authors.forename: S H
authors.initials: SH
authors.lastname: Stern
authors.forename: P
authors.initials: P
authors.lastname: Fraser
authors.forename: R
authors.initials: R
authors.lastname: Partridge
authors.forename: B
authors.initials: B
authors.lastname: Murawski
authors.forename: S
authors.initials: S
authors.lastname: Khoshbin
authors.forename: B L
authors.initials: BL
authors.lastname: Holman
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000662:Amphetamines; D003072:Cognition Disorders / Q000175:diagnosis / Q000000981:diagnostic imaging* / Q000209:etiology; D005260:Female; D006801:Humans; D007457:Iodine Radioisotopes; D020367:Iofetamine; D008180:Lupus Erythematosus, Systemic / Q000150:complications / Q000000981:diagnostic imaging* / Q000523:psychology; D008297:Male; D008875:Middle Aged; D019964:Mood Disorders / Q000175:diagnosis / Q000000981:diagnostic imaging / Q000209:etiology; D009483:Neuropsychological Tests; D010865:Pilot Projects; D015899:Tomography, Emission-Computed, Single-Photon
chemical_list: D000662:Amphetamines; D007457:Iodine Radioisotopes; D020367:Iofetamine