title: Tissue distribution of MHC class II--positive cells, their down-manipulation by monoclonal antibodies and potential role in organ allograft immunogenicity.
abstract: This review article presents current state of knowledge of tissue distribution of MHC class II antigens in rat kidney. Our attention focuses particularly on down manipulation of these antigens by monoclonal antibodies. The results of organ perfusion procedure on prolongation of graft survival and perspectives of further studies are also discussed.
authors.affiliation: Department of Nephrology, Christian Albrechts University, Kiel, Germany.
authors.forename: M
authors.initials: M
authors.lastname: Krzymański
authors.forename: W
authors.initials: W
authors.lastname: Müller-Ruchholtz
mesh_terms: D000818:Animals; D000911:Antibodies, Monoclonal / Q000494:pharmacology; D015536:Down-Regulation; D000949:Histocompatibility Antigens Class II / Q000378:metabolism*; D007165:Immunosuppression Therapy; D007668:Kidney / Q000276:immunology*; D016030:Kidney Transplantation / Q000276:immunology; D051381:Rats; D014018:Tissue Distribution; D014184:Transplantation, Homologous
chemical_list: D000911:Antibodies, Monoclonal; D000949:Histocompatibility Antigens Class II