Angiotensin-1-converting enzyme activity as index of pulmonary damage in thermal injury with or without smoke inhalation.
Serum angiotensin-converting enzyme (ACE) activity, plasma renin activity (PRA), and serum aldosterone levels were measured up to four weeks in a population of adults exposed to thermal injury, with or without concomitant exposure to smoke inhalation. In 10 patients, plasma levels of angiotensin-2 and ACE activity in bronchial lavage were also evaluated. Patients with severe burn injury had a significant decline of serum ACE activity while the concentrations of aldosterone and PRA were markedly elevated. Smoke inhalation seemed to counterbalance the decline of serum ACE activity, and, in the last group of patients, ACE concentrations were higher than those recorded in patients suffering only from cutaneous burn. The ACE activity was evidenced in bronchial lavage of patients exposed to smoke inhalation with the highest values present in the first day after the injury. The same patients had also very elevated levels of plasma angiotensin 2. In conclusion, serum ACE activity decreases in burn patients according to the severity of the cutaneous burn; smoke inhalation influences serum levels of the enzyme with concentration values opposite to the low ones present in cutaneous burn. Finally, the enzyme activity has an independent pattern from that of the other components of the renin angiotensin aldosterone system. The evaluation of ACE activity may be a marker of pulmonary damage in smoke inhalation.
Brizio-Molteni
L
L
Department of Pathology, Northwestern University Medical School, Chicago, IL 60611.
Piano
G
G
Warpeha
R L
RL
Solliday
N H
NH
Molteni
A
A
Angelats
J
J
Lewis
N
N
Patejak-Radwanski
H
H
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000804:Angiotensin II / Q000097:blood; D015415:Biomarkers; D001992:Bronchoalveolar Lavage Fluid / Q000201:enzymology; D002056:Burns / Q000097:blood / Q000150:complications / Q000201:enzymology*; D006801:Humans; D008168:Lung / Q000201:enzymology / Q000473:pathology; D008171:Lung Diseases / Q000097:blood / Q000150:complications / Q000201:enzymology*; D008875:Middle Aged; D007703:Peptidyl-Dipeptidase A / Q000097:blood*; D015208:Smoke Inhalation Injury / Q000097:blood / Q000150:complications / Q000201:enzymology*
D015415:Biomarkers; D000804:Angiotensin II; D007703:Peptidyl-Dipeptidase A