[Clinical importance of granulocyte-specific antibodies].
Clinical and laboratory data of 184 patients with immune neutropenia were evaluated. They suffered from autoimmune neutropenia (n = 165), alloimmune neonatal neutropenia (n = 18) and from transfusion-associated lung injury (n = 1). Autoimmune neutropenia was predominantly found in patients below 3 years. Patients were usually affected by benign bacterial infections. The peripheral blood count showed normal or diminished leukocyte counts with median absolute neutrophil counts of 285 cells/microliters. Bone marrow examination revealed in 60% of the cases a hypercellular marrow with a shift to the left. In 36% the bone marrow was normal and in 4% a hypocellular marrow was found. Spontaneous remission occurred in all newborns and, so far, in 4 patients with autoimmune neutropenia. Symptomatic treatment of the infections was sufficient in most of the patients.
Bux
J
J
Institut für Klinische Immunologie und Transfusionsmedizin, Klinikum der Justus-Liebig-Universität Giessen, BRD.
Kissel
K
K
Nowak
K
K
Spengel
U
U
Mueller-Eckhardt
C
C
D000293:Adolescent; D000328:Adult; D001327:Autoimmune Diseases / Q000097:blood*; D001787:Blood Group Incompatibility / Q000097:blood*; D001803:Blood Transfusion; D002648:Child; D002675:Child, Preschool; D005260:Female; D005455:Fluorescent Antibody Technique; D006098:Granulocytes / Q000276:immunology*; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007518:Isoantibodies / Q000097:blood*; D007519:Isoantigens / Q000276:immunology*; D007958:Leukocyte Count; D008297:Male; D008875:Middle Aged; D009503:Neutropenia / Q000097:blood*; D009894:Opportunistic Infections / Q000097:blood; D012127:Respiratory Distress Syndrome, Newborn / Q000097:blood
D007518:Isoantibodies; D007519:Isoantigens
Klinische Bedeutung von granulozytenspezifischen Antikörpern.