title: Phenobarbital-responsive episodic dyscontrol (rage) in dogs.
abstract: Episodic dyscontrol (rage) was diagnosed from the clinical history, electroencephalographic findings, and response to oral treatment with phenobarbital in 3 dogs. Clinical features included a mood change heralding aggressive incidents, explosive aggression directed at people or objects, and a postaggressive phase characterized by lethargy and lack of responsiveness. Abnormal electroencephalographic findings included spike activity in the temporal recordings. All 3 dogs responded well to anticonvulsant medication with phenobarbital.
authors.affiliation: Department of Surgery, Tufts University School of Veterinary Medicine, North Grafton, MA 01536.
authors.forename: N H
authors.initials: NH
authors.lastname: Dodman
authors.forename: K A
authors.initials: KA
authors.lastname: Miczek
authors.forename: K
authors.initials: K
authors.lastname: Knowles
authors.forename: J G
authors.initials: JG
authors.lastname: Thalhammer
authors.forename: L
authors.initials: L
authors.lastname: Shuster
mesh_terms: D000374:Aggression / Q000187:drug effects*; D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects*; D004283:Dog Diseases / Q000188:drug therapy*; D004285:Dogs; D004569:Electroencephalography / Q000662:veterinary; D004833:Epilepsy, Temporal Lobe / Q000188:drug therapy / Q000662:veterinary*; D005500:Follow-Up Studies; D008297:Male; D010634:Phenobarbital / Q000494:pharmacology / Q000627:therapeutic use*; D013577:Syndrome
chemical_list: D010634:Phenobarbital