title: Granulocytic sarcomas of small intestine and brain are associated with acute myelomonocytic leukaemia with abnormal eosinophils and inversion of chromosome 16.
abstract: We report two cases of acute myelomonocytic leukaemia with abnormal eosinophils (M4Eo) in which the presenting feature was small bowel obstruction. We suggest there is a unique clinicopathological association between small intestine involvement with leukaemia and the M4Eo subtype. Central nervous system involvement by myeloblastoma occurred in one of the two cases which is a recognised feature of M4Eo and should necessitate prophylaxis with intrathecal therapy. Inversion of chromosome 16 which is a cytogenetic marker for M4Eo was demonstrable in one of the two cases.
authors.affiliation: University College and Middlesex School of Medicine, London, UK.
authors.forename: M S
authors.initials: MS
authors.lastname: Hamilton
authors.forename: P
authors.initials: P
authors.lastname: Shepherd
authors.forename: J
authors.initials: J
authors.lastname: Porter
authors.forename: J D
authors.initials: JD
authors.lastname: Richards
mesh_terms: D014408:Biomarkers, Tumor; D001856:Bone Marrow Examination; D002540:Cerebral Cortex / Q000473:pathology*; D007446:Chromosome Inversion; D002885:Chromosomes, Human, Pair 16 / Q000648:ultrastructure*; D003937:Diagnosis, Differential; D004379:Duodenal Neoplasms / Q000235:genetics / Q000473:pathology*; D004804:Eosinophils / Q000473:pathology*; D005260:Female; D006801:Humans; D015994:Incidence; D007415:Intestinal Obstruction / Q000175:diagnosis / Q000209:etiology; D007580:Jejunal Neoplasms / Q000235:genetics / Q000473:pathology*; D007951:Leukemia, Myeloid / Q000453:epidemiology / Q000473:pathology*; D015479:Leukemia, Myelomonocytic, Acute / Q000145:classification / Q000175:diagnosis / Q000235:genetics / Q000473:pathology*; D017254:Leukemic Infiltration / Q000453:epidemiology / Q000473:pathology*; D007958:Leukocyte Count; D008297:Male; D008875:Middle Aged; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000175:diagnosis; D011379:Prognosis
chemical_list: D014408:Biomarkers, Tumor