Pharmacological properties and toxicology of MED-15, a prodrug of tolmetin.
In this study the pharmacological evaluation of MED-15, a non-acidic prodrug of tolmetin, is described. After oral administration the new compound shows a marked anti-inflammatory activity similar to that of tolmetin, but with minor ulcerogenic action and lower acute toxicity.
Caruso
A
A
Institute of Pharmacology, University of Catania Medical School, Italy.
Cutuli
V M
VM
De Bernardis
E
E
Attaguile
G
G
Amico-Roxas
M
M
D000284:Administration, Oral; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology* / Q000633:toxicity; D005260:Female; D005998:Glycine / Q000031:analogs & derivatives* / Q000494:pharmacology / Q000633:toxicity; D007928:Lethal Dose 50; D008297:Male; D010437:Peptic Ulcer / Q000139:chemically induced; D011355:Prodrugs / Q000494:pharmacology* / Q000633:toxicity; D011758:Pyrroles / Q000494:pharmacology* / Q000633:toxicity; D051381:Rats; D017208:Rats, Wistar; D014046:Tolmetin / Q000494:pharmacology* / Q000633:toxicity
D000894:Anti-Inflammatory Agents, Non-Steroidal; D011355:Prodrugs; D011758:Pyrroles; C065762:ST 679; D014046:Tolmetin; D005998:Glycine