title: [Microcirculatory changes in patients with hypertensive disease caused by excessively lowered blood pressure after clofelin administration].
abstract: In 20 patients with Stage II hypertensive disease, erythrocyte and platelet aggregation to response to ATP was photooptically studied, skin oxygen tension was polarographically examined, and the diameters of conjunctival vessels were microscopically measured. In the patients, excessive decreases in blood pressure were found to lead to lack of microvascular tone coordination, to increases in platelet and erythrocyte aggregation and to decreases in tissue oxygen supply. It was emphasized that the microcirculation and tissue oxygen supply should be monitored when clofelin dosages are chosen individually in the treatment of hypertensive disease.
authors.forename: V I
authors.initials: VI
authors.lastname: Kozlovskiĭ
authors.forename: G Ia
authors.initials: GIa
authors.lastname: Khulup
authors.forename: V I
authors.initials: VI
authors.lastname: Koshelapov
mesh_terms: D000328:Adult; D001794:Blood Pressure / Q000187:drug effects*; D003000:Clonidine / Q000009:adverse effects* / Q000627:therapeutic use; D004912:Erythrocytes / Q000187:drug effects; D005260:Female; D006801:Humans; D006973:Hypertension / Q000097:blood / Q000188:drug therapy*; D008297:Male; D008833:Microcirculation / Q000187:drug effects*; D008875:Middle Aged; D010101:Oxygen Consumption / Q000187:drug effects; D010974:Platelet Aggregation / Q000187:drug effects
chemical_list: D003000:Clonidine
vernacular_title: Izmeneniia mikrotsirkuliatsii u bol'nykh gipertonicheskoĭ bolezn'iu, obuslovlennye izbytochnym snizheniem arterial'nogo davleniia posle priema klofelina.