[Effects of parenteral nutrition on cell cycle kinetics in gastric cancer patients].
Studies were made on tumor growth changes by 1-week supplementary parenteral nutrition in undernourished advanced gastric cancer patients. Biopsy of the normal mucosa and cancerous tissue were taken through endoscope before and one week after parenteral nutrition and at the time of operation. Percentage of cells in various phases were analyzed by flow cytometry. The frequency of S and proliferative phases were markedly increased (P < 0.05) in cancerous tissue but not in the normal mucosa. These results demonstrate that a stimulating effect may be present in tumor cell kinetics and hence, the use of a cycle-specific chemotherapeutic agent is indicated.
Cao
W X
WX
Rui Jin Hospital, Shanghai Second Medical University.
D000782:Aneuploidy; D002453:Cell Cycle; D004273:DNA, Neoplasm / Q000235:genetics; D005260:Female; D005434:Flow Cytometry; D005753:Gastric Mucosa / Q000473:pathology; D006801:Humans; D008297:Male; D008875:Middle Aged; D010288:Parenteral Nutrition / Q000009:adverse effects; D016196:S Phase; D013274:Stomach Neoplasms / Q000473:pathology* / Q000628:therapy
D004273:DNA, Neoplasm