Cytogenetic findings in three primary hepatocellular carcinomas.
Short-term cultures of three primary hepatocellular carcinomas were cytogenetically analyzed. Case 1 displayed a normal karyotype. Case 2 had, in addition to cells with a normal male chromosome complement, a clone with -Y. In case 3, two abnormal clones were found, one with -Y and one with a highly aberrant karyotype: [formula: see text] Our results, collated with the findings in one previously published primary hepatocellular carcinoma and in three cell lines, suggest that structural changes of chromosomes 1 and 6, leading to loss of 1p and 6q material, and loss of chromosome 16 are frequent events in hepatocellular carcinogenesis.
Bardi
G
G
Department of Clinical Genetics, Lund University Hospital, Sweden.
Johansson
B
B
Pandis
N
N
Heim
S
S
Mandahl
N
N
Andrén-Sandberg
A
A
Hägerstrand
I
I
Mitelman
F
F
D000368:Aged; D006528:Carcinoma, Hepatocellular / Q000235:genetics* / Q000473:pathology* / Q000601:surgery; D002460:Cell Line; D002869:Chromosome Aberrations; D006801:Humans; D007621:Karyotyping; D008099:Liver / Q000473:pathology; D008113:Liver Neoplasms / Q000235:genetics* / Q000473:pathology* / Q000601:surgery; D008297:Male; D014407:Tumor Cells, Cultured