title: [The IgE system].
abstract: The IgE synthesis is regulated by a system of immunocompetent cells (B and T lymphocytes) and cytokines (IL-4, IFN gamma, IL-2, IL-5, IL-6) produced by T cells as a response to antigenic stimuli. IL-4 alone, or associated with other cytokines, determines the CD23+ receptor (FCERII) expression on monocytes-macrophages, eosinophiles, platelets, epidermidis Langerhans cells and B lymphocytes surfaces, inducing its cleavage in a Soluble Factor (IgE-BF), that increases the IgE synthesis. IFN-gamma, on the other hand, plays an inhibitory role on T-dependent phenomena, IL-4-mediated. In patients affected by atopic diseases, associated with oculorhinites, dermatitis and hyper-IgE syndrome, are found high serum levels of IgE, eosinophiles, and a large number of CD23+ cells: this indicates the hyper-reactivity of the IgE system and the IL-4 overproduction.
authors.affiliation: Istituto di Clinica Medica III, Università La Sapienza, Roma.
authors.forename: C
authors.initials: C
authors.lastname: Di Monaco
authors.forename: O
authors.initials: O
authors.lastname: Tanzilli
authors.forename: F
authors.initials: F
authors.lastname: Guido
authors.forename: M F
authors.initials: MF
authors.lastname: Cossu
authors.forename: A
authors.initials: A
authors.lastname: Amoroso
mesh_terms: D000818:Animals; D001402:B-Lymphocytes / Q000276:immunology / Q000378:metabolism; D016207:Cytokines / Q000502:physiology; D006801:Humans; D007073:Immunoglobulin E / Q000096:biosynthesis / Q000276:immunology / Q000502:physiology*; D017455:Receptors, IgE / Q000378:metabolism; D013601:T-Lymphocytes / Q000276:immunology / Q000378:metabolism
chemical_list: D016207:Cytokines; D017455:Receptors, IgE; D007073:Immunoglobulin E
vernacular_title: Il sistema IgE.