[Effectiveness of local prostaglandin instillations in tubal pregnancy in relation to preoperative beta-HCG level].
33 patients with tubal pregnancy and beta-HCG level less than 2500 mIU/ml were treated with local, laparoscopic Prostaglandin-injection. Re-operation was not necessary and beta-HCG fell to undetectable levels in 73% (p = 0.05). Serial beta-HCG correlated poorly with outcome. In patients with an increasing beta-HCG success was limited to 55% (p = 0.59). In contrast patients with falling or stable beta-HCG values had success rates of 85.7% (p = 0.22) and 83.5% (p = 0.30) respectively. Our data suggests there may be a clinical advantage to the use of prostaglandin-injection for the conservative management of early ectopic pregnancy. However the utility of preoperative serial beta-HCG values in predicting success showed a trend, without reaching statistical significance.
Spitzer
D
D
Landesfrauenklinik Salzburg.
Steiner
H
H
Batka
M
M
Staudach
A
A
D000020:Abortifacient Agents, Nonsteroidal / Q000008:administration & dosage; D006063:Chorionic Gonadotropin / Q000097:blood*; D018997:Chorionic Gonadotropin, beta Subunit, Human; D015237:Dinoprost / Q000008:administration & dosage*; D015232:Dinoprostone / Q000008:administration & dosage / Q000031:analogs & derivatives; D005260:Female; D006801:Humans; D015552:Injections, Intralesional; D007273:Injections, Intramuscular; D010535:Laparoscopy; D010446:Peptide Fragments / Q000097:blood*; D011247:Pregnancy; D011274:Pregnancy, Tubal / Q000097:blood / Q000188:drug therapy*
D000020:Abortifacient Agents, Nonsteroidal; D006063:Chorionic Gonadotropin; D018997:Chorionic Gonadotropin, beta Subunit, Human; D010446:Peptide Fragments; C016767:sulprostone; D015237:Dinoprost; D015232:Dinoprostone
Wirksamkeit lokaler Prostaglandin-Instillationen bei Tubargraviditäten in Abhängigkeit vom präoperativen beta-HCG Verlauf.