title: [Changes in the level of DNA synthesis in a culture of Ehrlich ascites tumor cells under the action of different concentrations of a chalone-containing preparation].
abstract: The study was made of the effect of various concentrations of chalone-containing preparation from ascitic Ehrlich tumor on DNA synthesis in the tumor. The preparation was shown to suppress DNA synthesis in dose-dependent manner. The dose dependence was characterized by the effect of saturation which is likely to reflect binding of chalone molecules with specific cell receptors.
authors.forename: D S
authors.initials: DS
authors.lastname: Gembitskiĭ
authors.forename: A I
authors.initials: AI
authors.lastname: Antokhin
authors.forename: Iu A
authors.initials: IuA
authors.lastname: Romanov
authors.forename: N Ia
authors.initials: NIa
authors.lastname: Popova
mesh_terms: D000818:Animals; D002286:Carcinoma, Ehrlich Tumor / Q000378:metabolism*; D004273:DNA, Neoplasm / Q000096:biosynthesis / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D006131:Growth Inhibitors / Q000494:pharmacology*; D008297:Male; D051379:Mice; D009368:Neoplasm Transplantation; D014407:Tumor Cells, Cultured / Q000187:drug effects / Q000378:metabolism
chemical_list: D004273:DNA, Neoplasm; D006131:Growth Inhibitors
vernacular_title: Izmenenie urovnia sinteza DNK v kul'ture kletok astsitnoĭ opukholi Erlikha pod deĭstviem razlichnykh kontsentratsiĭ keĭlonsoderzhashchego preparata.