[The effect of the inhalation of ethanol and acetone on the indices of the antioxidant protection system and on lipid peroxidation in the brain tissue and blood serum of rats].
Ethanol or acetone inhalation resulted in a reduction in motor activity in rats, affecting largely their explorative behavior. The biochemical parameters of free-radical processes (catalyse and SOD activities, LPO levels) remained unchanged in the inhaling animals. Ethanol or acetone inhalation caused a significant decrease in blood catalyse activity and serum LPO levels. The acetone- and ethanol-induced changes in the activity of ceruloplasmin were heterodirectional. It can be concluded that it is useful to study the biochemical parameters of serum free-radical processes and to employ the findings in the therapy of inhalation toxicomanias.
Burmistrov
S O
SO
Mashek
O N
ON
Stepanova
I I
II
D000096:Acetone / Q000008:administration & dosage*; D000280:Administration, Inhalation; D000818:Animals; D000975:Antioxidants; D001522:Behavior, Animal / Q000187:drug effects; D001769:Blood / Q000187:drug effects*; D001921:Brain / Q000187:drug effects* / Q000201:enzymology; D001923:Brain Chemistry / Q000187:drug effects; D000431:Ethanol / Q000008:administration & dosage*; D005609:Free Radicals; D015227:Lipid Peroxidation / Q000187:drug effects*; D008297:Male; D051381:Rats; D013997:Time Factors
D000975:Antioxidants; D005609:Free Radicals; D000096:Acetone; D000431:Ethanol
Vliianie ingaliatsii étanola i atsetona na pokazateli sistemy antioksidantnoĭ zashchity i perekisnoe okislenie lipidov tkani mozga i syvorotki krovi krys.