[Effects of isosorbide dinitrate on regional cerebral blood flow and intracranial pressure in cats].
The effects of isosorbide dinitrate (ISDN) on regional cerebral blood flow (rCBF) and intracranial pressure (ICP) were examined in cats. A low dose of ISDN (2.5 micrograms/kg/min) infusion did not show any changes in cerebral hemodynamics. During high dose of ISDN (5.0 micrograms/kg/min) or NTP (5.0 micrograms/kg/min) infusion, mean blood pressure (mBP) decreased by 10 to 20% accompanied by decreased cerebral perfusion pressure (CPP: mBP-ICP), however, rCBF or ICP did not change. It is concluded that intravenous administrations of ISDN in a dose of 2.5-5.0 micrograms/kg/min that produce slight decrease in blood pressure did not influence on cerebral hemodynamics.
Ishikawa
T
T
Department of Anesthesiology Resuscitology, Yamaguchi University, School of Medicine, Japan.
Funatsu
N
N
Nakanishi
O
O
Maekawa
T
T
Sakabe
T
T
D000818:Animals; D001921:Brain / Q000098:blood supply*; D002415:Cats; D007262:Infusions, Intravenous; D007427:Intracranial Pressure / Q000187:drug effects*; D007548:Isosorbide Dinitrate / Q000008:administration & dosage / Q000494:pharmacology*; D009599:Nitroprusside / Q000494:pharmacology; D012039:Regional Blood Flow / Q000187:drug effects; D014655:Vascular Resistance / Q000187:drug effects
D009599:Nitroprusside; D007548:Isosorbide Dinitrate