[The comparative characteristics of the biological and immunomodulating activities of enzyme preparations of microbial origin].
A number of enzyme preparations of microbial origin such as immunomodulators and immunostimulators have been studied in vitro according to reactions of rosette technique of cell (ROC) active and general, adhesion, activation of a complement and also the spontaneous activity and phagocytosis of neutrophils have been determined. The enzyme preparations of microbial origin have been shown to be capable of causing immunomodulation and of influencing the specific and nonspecific immune response. Unlike the enzymes of animal origin the enzymes of microbial origin are effective in smaller concentrations. The studied preparations modulate the immune response differently according to ROC, adhesion. Each of preparations has specific features of biological activity--bacterio-stationary in reaction to a certain group of microorganisms and some specific features of reaction with cell and levels of immune reactions.
Dobrotina
N A
NA
Ezhova
G P
GP
Kazatskaia
Zh A
ZhA
Ladygina
G N
GN
Kurova
M V
MV
D000276:Adjuvants, Immunologic / Q000494:pharmacology*; D000818:Animals; D001412:Bacillus subtilis / Q000201:enzymology; D001419:Bacteria / Q000201:enzymology*; D003167:Complement Activation / Q000187:drug effects; D004798:Enzymes / Q000494:pharmacology*; D008163:Luminescent Measurements; D009504:Neutrophils / Q000187:drug effects; D016897:Respiratory Burst / Q000187:drug effects; D012397:Rosette Formation; D012706:Serratia marcescens / Q000201:enzymology; D013302:Streptomyces / Q000201:enzymology; D013601:T-Lymphocytes / Q000187:drug effects / Q000276:immunology
D000276:Adjuvants, Immunologic; D004798:Enzymes
Sravnitel'naia kharakteristika biologicheskoĭ i immunomoduliruiushcheĭ aktivnosti nekotorykh fermentnykh preparatov mikrobnogo proiskhozhdeniia.