title: [Association studies in cancerology: the example of gene L-myc polymorphism associated with the incidence of pulmonary metastases in breast cancers].
abstract: Genes, which are implicated in the pathogenesis of human tumors, may demonstrate Restriction Fragment Length Polymorphism (RFLP). Population studies of such RFLP are of potential interest for a genetic analysis of cancer susceptibility. The initial data of Krontiris et al has shown a significant increase of rare c-Ha-ras-1 alleles in individuals with tumors. Since then, other significant associations have been found between other genes RFLPs and various tumors. In this paper, we report that L-myc RFLP may prove useful in identifying breast cancer patients at high risk of developing lung metastases.
authors.affiliation: Laboratoire d'oncovirologie, centre René-Huguenin, Saint-Cloud, France.
authors.forename: M H
authors.initials: MH
authors.lastname: Champème
authors.forename: I
authors.initials: I
authors.lastname: Bièche
authors.forename: A
authors.initials: A
authors.lastname: Latil
authors.forename: K
authors.initials: K
authors.lastname: Hacène
authors.forename: R
authors.initials: R
authors.lastname: Lidereau
mesh_terms: D000328:Adult; D001943:Breast Neoplasms / Q000235:genetics*; D004198:Disease Susceptibility; D005260:Female; D016259:Genes, myc; D006801:Humans; D008175:Lung Neoplasms / Q000235:genetics / Q000556:secondary*; D008875:Middle Aged; D011110:Polymorphism, Genetic; D012189:Retrospective Studies
vernacular_title: Etudes d'association en cancérologie: l'exemple du polymorphisme du gène L-myc associé à l'incidence de métastases pulmonaires dans le cancer du sein.