title: [Anaphylactic shock due to modified fluid gels: 2 case reports].
abstract: Colloid solutions can give severe anaphylactic accidents. We are reporting two cases from our department.
  
  
  METHODS
  a sixty eight years old man perfused with Plasmion solution (Gelatin plasma substitute) before spinal anesthesia, presented sudden hypotension and diffuse skin rush. Second case: a twelve years old girl, receiving a Plasmion solution to correct a hypovolemic shock in I.C.U, presented a severe bronchospasm and a worsening of the hypotension. These accidents are explained by immunologic reactions or by direct histamine release. Their incidence is between 0.01 and 0.8 percent depending on the used solution. They are prevented by an antihistaminic premedication for the gelatin plasma substitutes and by an haptenic inhibition for Dextran (polysaccharide plasma substitutes). The new colloid solutions, based on hydroxyethylstarch, seems to give much less allergic reactions.
authors.affiliation: Faculté de Médecine de l'Université Saint-Joseph.
authors.forename: G
authors.initials: G
authors.lastname: Hayeck
authors.forename: A
authors.initials: A
authors.lastname: Yazigi
authors.forename: P
authors.initials: P
authors.lastname: Yazbeck
authors.forename: M C
authors.initials: MC
authors.lastname: Antakly
mesh_terms: D000368:Aged; D000707:Anaphylaxis / Q000139:chemically induced* / Q000453:epidemiology / Q000276:immunology / Q000517:prevention & control; D002648:Child; D003911:Dextrans / Q000627:therapeutic use; D005260:Female; D005780:Gelatin / Q000009:adverse effects*; D006633:Histamine Antagonists / Q000627:therapeutic use; D006801:Humans; D008297:Male; D010952:Plasma Substitutes / Q000009:adverse effects*; D011292:Premedication
chemical_list: D003911:Dextrans; D006633:Histamine Antagonists; D010952:Plasma Substitutes; C013648:plasmion; D005780:Gelatin
vernacular_title: Choc anaphylactique aux gélatines fluides modifiées: à propos de deux cas.