Differential stimulation of hepatic and brain metallothioneins by ethanol.
Administration of ethanol induces the synthesis of hepatic metallothionein and metallothionein mRNA in the liver but not in the brain. Furthermore, ethyl alcohol, methyl alcohol and isopropyl alcohol enhance the synthesis of metallothionein in Chang cells but not in neuroblastoma IMR-32 cells in culture. The results of this study are interpreted to suggest that the mechanisms of synthesis of metallothionein and the utilization of essential metal nutrients in the brain and peripheral tissues are not identical.
Ebadi
M
M
Department of Pharmacology, University of Nebraska College of Medicine, Omaha 68198-6260.
Pfeiffer
R F
RF
Huff
A
A
D000433:1-Propanol / Q000494:pharmacology; D000818:Animals; D001921:Brain / Q000187:drug effects / Q000378:metabolism*; D002104:Cadmium / Q000494:pharmacology; D003513:Cycloheximide / Q000494:pharmacology; D000431:Ethanol / Q000494:pharmacology*; D006801:Humans; D008099:Liver / Q000187:drug effects / Q000378:metabolism*; D008297:Male; D008668:Metallothionein / Q000096:biosynthesis* / Q000235:genetics; D000432:Methanol / Q000494:pharmacology; D009447:Neuroblastoma / Q000378:metabolism; D012333:RNA, Messenger / Q000096:biosynthesis; D051381:Rats; D017207:Rats, Sprague-Dawley; D014407:Tumor Cells, Cultured; D015032:Zinc / Q000378:metabolism / Q000494:pharmacology
D012333:RNA, Messenger; D002104:Cadmium; D000431:Ethanol; D008668:Metallothionein; D000433:1-Propanol; D003513:Cycloheximide; D015032:Zinc; D000432:Methanol