title: A new bioabsorbable material for rat vascular cuff anatomosis: establishment for the long-term orthotopic liver transplantation model.
abstract: Rat vascular anastomosis was performed using a newly synthesized bioabsorbable material (LA-GA copolymer) cuffs and the ordinary polyethylene cuffs. The LA-GA copolymer cuff which anastomosed the portal vein and the inferior vena cava were patent and developed no collateral veins even after 6 months, keeping the transplanted liver normal. By contrast, the polyethylene cuff anastomosed portal vein was completely occluded and the collateral veins were highly developed, with the transplanted liver showing the fatty degeneration of hepatocytes and numerous regenerative nodules. It is concluded that the LA-GA copolymer cuff is a suitable material for the short and long term study of rat orthotopic liver transplantation.
authors.affiliation: Second Department of Surgery, Faculty of Medicine, Kyoto University, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Kitakado
authors.forename: K
authors.initials: K
authors.lastname: Tanaka
authors.forename: K
authors.initials: K
authors.lastname: Asonuma
authors.forename: S
authors.initials: S
authors.lastname: Uemoto
authors.forename: S
authors.initials: S
authors.lastname: Matsuoka
authors.forename: H
authors.initials: H
authors.lastname: Utsunomiya
authors.forename: R
authors.initials: R
authors.lastname: Okamura
authors.forename: T
authors.initials: T
authors.lastname: Katayama
authors.forename: Y
authors.initials: Y
authors.lastname: Inomata
authors.forename: K
authors.initials: K
authors.lastname: Ozawa
mesh_terms: D000042:Absorption; D000714:Anastomosis, Surgical / Q000379:methods; D000818:Animals; D001672:Biocompatible Materials; D001673:Biodegradation, Environmental; D006016:Glycolates; D007773:Lactates; D019344:Lactic Acid; D016031:Liver Transplantation / Q000379:methods; D008297:Male; D011095:Polyethylenes; D011108:Polymers; D011169:Portal Vein / Q000601:surgery*; D051381:Rats; D017208:Rats, Wistar; D014682:Vena Cava, Inferior / Q000601:surgery*
chemical_list: D001672:Biocompatible Materials; D006016:Glycolates; D007773:Lactates; D011095:Polyethylenes; D011108:Polymers; C031149:glycolic acid; D019344:Lactic Acid