[Radioprotective action of gas hypoxia (8%) in local irradiation of the kidneys].
The radioprotective action of hypoxia in local irradiation of kidneys was studied. The experiments were carried out on hybrid mice (CBA x C57Bl) exposed to local X-ray irradiation through a lead diaphragm matched to the kidneys. In the experimental group the animals breathed in gaseous mixture with 8% of oxygen prior to and during irradiation. 20-36 weeks after irradiation the functions of glomerular and juxtaglomerular systems, as well as mass of native and dried kidneys were studied in the animals. It is shown that hypoxia efficiently protects kidneys against irradiation and permits increasing the supplied dose of radiation at least by 25%. High-efficient protection is retained when passing from single to fractionated irradiation.
Ostapenko
V V
VV
Waĭnson
A A
AA
D000818:Animals; D015687:Cell Hypoxia; D007668:Kidney / Q000187:drug effects* / Q000293:injuries / Q000378:metabolism / Q000528:radiation effects; D051379:Mice; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D010100:Oxygen / Q000627:therapeutic use*; D011829:Radiation Dosage; D011833:Radiation Injuries, Experimental / Q000378:metabolism / Q000517:prevention & control*; D011836:Radiation Tolerance
D010100:Oxygen
Radiozashchitnoe deĭstvie gazovoĭ gipoksii (8%) pri lokalńom rentgenovskom obluchenii pochek.