Polyneuropathy following intra-muscular sodium aurothiomalate for rheumatoid arthritis--a case report.
A patient with rheumatoid arthritis developed rapid onset of peripheral neuropathy whilst on treatment with intra-muscular (IM) gold (Sodium Aurothiomalate). At the time of admission, the arthritis was relatively quiescent. Electromyogram showed evidence of sensorimotor polyneuropathy. Investigations excluded other causes of polyneuropathy. Sural nerve biopsy did not reveal inflammation or vasculitis. The patient's condition improved after cessation of gold therapy. Gold induced neuropathy should be considered in a patient with rheumatoid arthritis who presents with polyneuropathy while on gold therapy.
Koh
W H
WH
Department of Rheumatology and Immunology, Tan Tock Seng Hospital, Singapore.
Boey
M L
ML
D000328:Adult; D001172:Arthritis, Rheumatoid / Q000188:drug therapy* / Q000473:pathology; D001369:Axons / Q000187:drug effects / Q000473:pathology; D001706:Biopsy; D004576:Electromyography / Q000187:drug effects; D005260:Female; D006052:Gold Sodium Thiomalate / Q000008:administration & dosage / Q000009:adverse effects*; D006801:Humans; D007273:Injections, Intramuscular; D009410:Nerve Degeneration / Q000187:drug effects / Q000502:physiology; D009460:Neurologic Examination / Q000187:drug effects; D011115:Polyneuropathies / Q000139:chemically induced* / Q000175:diagnosis / Q000473:pathology; D013497:Sural Nerve / Q000187:drug effects / Q000473:pathology
D006052:Gold Sodium Thiomalate