The effects of immune globulin on endotoxemia.
Ten patients (mean age, 40 years; 2 women) with endotoxemia received 2.5 gm of immune globulin daily for 4 days or 5 gm daily for 2 days. In all patients, plasma endotoxin levels decreased to normal levels (< or = 9.8 pg/ml) within a mean of 3.2 days after starting immune globulin treatment, and body temperatures decreased to < 37 degrees C within 4.5 days. In 10 antibiotic-treated (control) patients with endotoxemia who did not receive immune globulin, plasma endotoxin levels declined to normal levels in 6 and their body temperatures dropped to normal levels within 5.0 days; no changes in body temperature were noted in the 4 patients whose plasma endotoxin levels did not decrease.
Endo
S
S
Iwate Medical University, Morioka, Japan.
Inada
K
K
Yamada
Y
Y
Takakuwa
T
T
Nakae
H
H
Kasai
T
T
Kikuchi
M
M
Terashima
M
M
Hoshi
S
S
Yoshida
M
M
D000328:Adult; D000368:Aged; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D001831:Body Temperature; D004731:Endotoxins / Q000097:blood* / Q000506:poisoning; D005260:Female; D006090:Gram-Negative Bacteria; D006801:Humans; D016756:Immunoglobulins, Intravenous / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged
D000900:Anti-Bacterial Agents; D004731:Endotoxins; D016756:Immunoglobulins, Intravenous