title: [Isolated memory disorders disclosing antiphospholipid antibody syndrome].
abstract: Most of the neurological complications of the antiphospholipid syndrome are consequences of arterial or venous cerebral thromboses. We report the case of a 46-year-old woman presenting with the main signs of antiphospholipid syndrome: Raynaud's phenomenon, livedo, leg ulcers, repeated miscarriages, presence of a circulating anticoagulant and of antiphospholipid antibodies, who developed an isolated amnestic syndrome with a peculiar pattern; 1) almost complete sparing of the ability to learn new skills and of short-term recall; 2) deterioration, followed by disappearance of recent memories after a sufficient delay; 3) progressive alteration of increasingly old memories including knowledge memory suggested a gradual alteration of mnestic traces. The lack of neuroradiological signs of multiple infarcts suggests a direct intervention of antibodies in this patient's memorisation mechanisms.
authors.affiliation: Service de Médecine Interne, Hôpital de la Timone, Marseille.
authors.forename: J R
authors.initials: JR
authors.lastname: Harle
authors.forename: P
authors.initials: P
authors.lastname: Disdier
authors.forename: A
authors.initials: A
authors.lastname: Ali Cherif
authors.forename: L
authors.initials: L
authors.lastname: Swiader
authors.forename: M L
authors.initials: ML
authors.lastname: Royere
authors.forename: P J
authors.initials: PJ
authors.lastname: Weiller
mesh_terms: D017152:Antibodies, Antiphospholipid / Q000302:isolation & purification; D016736:Antiphospholipid Syndrome / Q000150:complications*; D005260:Female; D006801:Humans; D008569:Memory Disorders / Q000209:etiology*; D008875:Middle Aged; D009483:Neuropsychological Tests
chemical_list: D017152:Antibodies, Antiphospholipid
vernacular_title: Troubles mnésiques isolés révélant un syndrome des anticorps anti-phospholipides.