Cathepsin G, a polymorphonuclear cell protease, affects the fibrinolytic system by releasing PAI-1 from endothelial cells and platelets.
Pintucci
G
G
Istituto di Ricerche Farmacologiche Mario Negri, Consorzio Mario Negri Sud, Santa Maria Imbaro, Chieti, Italy.
Iacoviello
L
L
Amore
C
C
Evangelista
V
V
Cerletti
C
C
Donati
M B
MB
D001792:Blood Platelets / Q000187:drug effects / Q000378:metabolism*; D056649:Cathepsin G; D002403:Cathepsins / Q000097:blood / Q000494:pharmacology*; D002478:Cells, Cultured; D017077:Culture Media, Conditioned; D004730:Endothelium, Vascular / Q000187:drug effects / Q000378:metabolism*; D005109:Extracellular Matrix / Q000378:metabolism; D006801:Humans; D009504:Neutrophils / Q000201:enzymology; D017395:Plasminogen Activator Inhibitor 1 / Q000097:blood / Q000302:isolation & purification / Q000378:metabolism*; D012697:Serine Endopeptidases; D015843:Serpins / Q000494:pharmacology; D014471:Umbilical Veins
D017077:Culture Media, Conditioned; D017395:Plasminogen Activator Inhibitor 1; D015843:Serpins; D002403:Cathepsins; D012697:Serine Endopeptidases; C534094:CTSG protein, human; D056649:Cathepsin G