N-benzyl-N-lactyl dithiocarbamate treatment of mice after chronic cadmium administration.
Administration of N-benzyl-N-lactyl dithiocarbamate (BLDTC) to mice after chronic cadmium (Cd) administration evoked a prompt, dose-dependent reduction of the whole body burden; 75% of the retained Cd was mobilized and excreted after 20 i.p. injections of BLDTC at 1.0 mmol/kg/injection. This same dose regimen produced 71% and 98% reductions of the renal and hepatic Cd concentrations, respectively. There was no reduction by BLDTC of the endogenous level of any of seven other metals measured: iron, magnesium, selenium, copper, calcium, zinc, and manganese. Renal proximal tubular damage in mice which received Cd followed by BLDTC was much less than that observed in kidneys from mice which received Cd alone. Chronic Cd administration led to substantial epithelial vacuolar damage to renal distal tubules, and this process was not apparently reversed or antagonized by BLDTC treatment to the extent observed in proximal tubules.
Gale
G R
GR
Ralph H. Johnson Department of Veterans Affairs Medical Center, Charleston, SC 29401.
Walker
E M
EM
Smith
A B
AB
Jones
M M
MM
Stone
A
A
Basinger
M A
MA
Singh
P K
PK
D000818:Animals; D001822:Body Burden; D002104:Cadmium / Q000493:pharmacokinetics*; D004187:Disaccharides / Q000494:pharmacology*; D007668:Kidney / Q000187:drug effects / Q000378:metabolism / Q000473:pathology; D008099:Liver / Q000187:drug effects / Q000378:metabolism; D008297:Male; D008670:Metals / Q000378:metabolism; D051379:Mice; D013859:Thiocarbamates / Q000494:pharmacology*; D013997:Time Factors
D004187:Disaccharides; D008670:Metals; D013859:Thiocarbamates; D002104:Cadmium; C071770:N-benzyl-4-O-(beta-galactopyranosyl)glucamine-N-carbodithioate