title: [The exclusively outpatient treatment of pulmonary tuberculosis under the conditions in Romania].
abstract: In order to demonstrate the possibility of an exclusively outpatient treatment of pulmonary tuberculosis in the present conditions in our country, a study was performed on 140 cases in Bucharest. The admission criteria were as follows: sputum negative patients (M-C-); paubacillary cases, sputum positive only in culture (M-C+); Tb pleuritis; patients refusing hospitalization, regardless their bacteriological status, and sputum positive cases also at smear examination (M+C+), if they had no household contacts under 20 years of age or with a good social economic standard of life. The patients were given the intensive chemotherapy regimen HSRZ 2/7 for 6 months, that was prolonged to 9 months in specified cases. A number of 31 patients were non-bacillary (M-C-) out of which 14 cases with pleuritis; 70 were paucibacillary (M-C+), and 39 were smear positive (M+C+). Out of 109 patients which were bacteriologically confirmed, sputum reversion in culture was obtained in 71.6% of cases at 2 months and in 89.0% at 3 months. At treatment end, sputum negativation was not obtained in a single patient (0.9%). Case follow-up for 6-41 months after treatment end led to the registration of 8 therapeutical failures and bacteriological relapses (5.7%). Five cases recovered through re-treatment, 1 patient (0.7%) died through tuberculosis, and 2 (1.4%) became chronic case. Periodical control of the 95 contact children in the respective households revealed a single conversion of the tuberculin reaction and no Tb case after treatment start in index cases, which proves the epidemiological reliability of the method.
authors.affiliation: Institutul de pneumoftiziologie Marius Nasta, Bucureşti.
authors.forename: P
authors.initials: P
authors.lastname: Mihăilescu
authors.forename: V
authors.initials: V
authors.lastname: Hartia
authors.forename: C
authors.initials: C
authors.lastname: Didilescu
authors.forename: E
authors.initials: E
authors.lastname: Ibraim
authors.forename: D
authors.initials: D
authors.lastname: Lugoji
authors.forename: D
authors.initials: D
authors.lastname: Chiotan
authors.forename: A M
authors.initials: AM
authors.lastname: Sasu
authors.forename: N
authors.initials: N
authors.lastname: Evian
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000553:Ambulatory Care; D000995:Antitubercular Agents / Q000627:therapeutic use; D002648:Child; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D012008:Recurrence; D012074:Remission Induction; D012383:Romania; D013183:Sputum / Q000382:microbiology; D013997:Time Factors; D014397:Tuberculosis, Pulmonary / Q000188:drug therapy* / Q000382:microbiology
chemical_list: D000995:Antitubercular Agents
vernacular_title: Tratamentul exclusiv ambulator al tuberculozei pulmonare în condiţiile ţării noastre.