title: [Cerebokrast as a corrector of postischemic phenomena in acute transient cerebral ischemia].
abstract: Acute cerebral ischemia in cats (both carotid arteries occlusion during 30 min after permanent occlusion of both vertebral arteries) was accompanied by postischemic hypoperfusion and hypo-oxygenation of the cerebral tissue. Intravenous infusion of cerebrocrast (1 micrograms.kg-1.min-1 during 60 min) prevented manifestation of the postischemic phenomena. Antihypoxic effect of cerebrocrast involved the cerebral blood flow increase, brain oxygen consumption lowering and Hb-O2-affinity decrease.
authors.forename: T G
authors.initials: TG
authors.lastname: Bazhenova
authors.forename: M B
authors.initials: MB
authors.lastname: Plotnikov
authors.forename: T M
authors.initials: TM
authors.lastname: Plotnikova
authors.forename: A S
authors.initials: AS
authors.lastname: Saratikov
mesh_terms: D000208:Acute Disease; D000818:Animals; D001921:Brain / Q000187:drug effects / Q000378:metabolism; D002121:Calcium Channel Blockers / Q000627:therapeutic use*; D002415:Cats; D004095:Dihydropyridines / Q000627:therapeutic use*; D004353:Drug Evaluation, Preclinical; D005260:Female; D006439:Hemodynamics / Q000187:drug effects; D002546:Ischemic Attack, Transient / Q000188:drug therapy* / Q000503:physiopathology; D008297:Male; D010101:Oxygen Consumption / Q000187:drug effects; D013997:Time Factors; D014665:Vasodilator Agents / Q000627:therapeutic use*
chemical_list: D002121:Calcium Channel Blockers; D004095:Dihydropyridines; D014665:Vasodilator Agents; C073838:2,6-dimethyl-3,5-bis(2'-propoxyethoxycarbonyl)-4-(2''-difluoromethoxyphenyl)-1,4-dihydropyridine
vernacular_title: Tserebrokrast kak korrektor postishemicheskikh fenomenov pri ostroĭ tranzitornoĭ ishemii mozga.