Effect of methylene blue on the vesicourethral function in the rats.
The bladder and urethral activities during the rhythmic bladder contractions were evaluated before and after the intraarterial administration of methylene blue, which prevents the activation of soluble guanylate cyclase. The methylene blue produced an increase in the bladder activity and a decrease in the urethral smooth muscle relaxant response induced with bladder contraction. The L-arginine/nitric oxide pathway seems to modulate the vesicourethral function.
Nishizawa
O
O
Department of Urology, Akita University School of Medicine.
Kawahara
T
T
Shimoda
N
N
Suzuki
K
K
Fujieda
N
N
Kudo
T
T
Suzuki
T
T
Noto
H
H
Harada
T
T
Tsuchida
S
S
D000758:Anesthesia; D000818:Animals; D007269:Injections, Intra-Arterial; D008751:Methylene Blue / Q000008:administration & dosage / Q000494:pharmacology*; D009119:Muscle Contraction / Q000187:drug effects; D009126:Muscle Relaxation / Q000187:drug effects; D009130:Muscle, Smooth / Q000187:drug effects; D051381:Rats; D014521:Urethra / Q000187:drug effects*; D001743:Urinary Bladder / Q000187:drug effects*
D008751:Methylene Blue