[Possible reasons for bilirubin accumulation in the brain of newborn animals during oxygen deficiency].
An increase in content of bilirubin was detected in brain tissue of newborn rats with chronic interrupted hypoxic hypoxia occurred during pre- and neonatal periods. Accumulation of bilidiene in animal brain tissues appears to occur due to the following causative factors: tissue acidosis, developed after oxygen deficiency, contributed to binding of bile pigment to brain cell plasma membranes, synaptosomal ones in particular; serum albumin lost its specific ability to bind bilirubin due to protein molecular accumulation of excessive fatty acids and acetaldehyde, which are bound to protein, as well as other minor ligands extracted by organic solvents.
Tkachenko
A V
AV
D000079:Acetaldehyde / Q000378:metabolism; D000818:Animals; D000831:Animals, Newborn; D001663:Bilirubin / Q000378:metabolism*; D001921:Brain / Q000378:metabolism*; D002462:Cell Membrane / Q000378:metabolism; D005227:Fatty Acids / Q000378:metabolism; D005311:Fetal Hypoxia / Q000378:metabolism*; D000860:Hypoxia / Q000378:metabolism*; D051381:Rats; D017208:Rats, Wistar
D005227:Fatty Acids; D000079:Acetaldehyde; D001663:Bilirubin
Vozmozhnye pricheny nakopleniia bilirubina v golovnom mozgu novorozhdennykh zhivotnykh pri kislorodnoĭ nedostatochnosti.