Urate causes the human polymorphonuclear leukocyte to secrete superoxide.
The human polymorphonuclear leukocyte generates O2-. and H2O2 when it is treated with uric acid. A transition metal catalyzed reaction between O2-. and H2O2 can give the hydroxyl radical and myeloperoxidase forms hypochlorous acid from H2O2 and chloride. Therefore, the uric acid-induced secretion of oxidants may be responsible for a large part of the inflammation associated with gout.
Thomas
M J
MJ
Department of Biochemistry, Wake Forest University, Bowman Gray School of Medicine, Winston-Salem, NC 27103.
D005609:Free Radicals / Q000097:blood; D006801:Humans; D009504:Neutrophils / Q000187:drug effects* / Q000378:metabolism; D013481:Superoxides / Q000097:blood*; D014527:Uric Acid / Q000494:pharmacology*
D005609:Free Radicals; D013481:Superoxides; D014527:Uric Acid