title: Evaluation of BACTEC 460 TB system for measurement of in vitro anti-Mycobacterium leprae activity of various antimicrobials.
abstract: In vitro anti-leprosy activities of various antimicrobials were measured by using the BACTEC 460 TB System. The Growth Index reducing activities of test drugs were strong in clofazimine, KRM-1648, rifabutin, clarithromycin and rifampicin; intermediate in sparfloxacin, minocycline and ofloxacin; and weak in ciprofloxacin, fleroxacin and DDS. Amikacin, pipemidic acid, enoxacin and norfloxacin had no such in vitro activities. There is a close correlation between in vitro and in vivo anti-M. leprae activities of a given agent, therefore indicating usefulness of the BACTEC 460 TB System in evaluation of in vitro anti-M. leprae activity of a given agent.
authors.affiliation: Department of Microbiology and Immunology, Shimane Medical University, Izumo, Japan.
authors.forename: H
authors.initials: H
authors.lastname: Tomioka
authors.forename: H
authors.initials: H
authors.lastname: Saito
authors.forename: K
authors.initials: K
authors.lastname: Sato
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D004352:Drug Resistance, Microbial; D051379:Mice; D008819:Mice, Nude; D008826:Microbial Sensitivity Tests / Q000379:methods*; D009166:Mycobacterium leprae / Q000187:drug effects*
chemical_list: D000900:Anti-Bacterial Agents