title: [Multivariate analysis of the clinical signs in late cortical cerebellar atrophy (LCCA) in Japan--compared with olivo-ponto-cerebellar atrophy (OPCA) and hereditary cortical cerebellar atrophy (HCCA)].
abstract: We investigated the clinical features of 179 patients with late cortical cerebellar atrophy (LCCA) comparing with 382 patients with olivo-ponto-cerebellar atrophy (OPCA) and 91 patients with hereditary cortical cerebellar atrophy (HCCA) using multivariate analysis. They had no significant difference in durations from onset. Disorders of finger-nose test were of more severity and disorders of heel-knee test were less involved in LCCA than in HCCA. Eye movements tended to be normal in LCCA. LCCA showed more depressive and euphoric character than OPCA and HCCA. Analysis of LCCA and OPCA demonstrated that LCCA revealed hypotonia in muscles, normal or weak reactions of muscle stretch reflexes. There existed 21.4 percent of cases which could not be discriminated by multivariate analysis using clinical signs in LCCA and OPCA. Multivariate analysis of LCCA and HCCA, which are very similar in clinical signs, showed 66.3 percent of discriminatory rate. Thus, we could diagnose them to a certain extent only by clinical signs.
authors.affiliation: Department of Neurology, Nara Medical University.
authors.forename: S
authors.initials: S
authors.lastname: Yanagimoto
authors.forename: T
authors.initials: T
authors.lastname: Takayanagi
authors.forename: K
authors.initials: K
authors.lastname: Hirayama
authors.forename: R
authors.initials: R
authors.lastname: Nakamura
authors.forename: N
authors.initials: N
authors.lastname: Yanagisawa
mesh_terms: D000368:Aged; D003937:Diagnosis, Differential; D005133:Eye Movements; D005260:Female; D006801:Humans; D007564:Japan / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D009849:Olivopontocerebellar Atrophies / Q000175:diagnosis / Q000453:epidemiology* / Q000503:physiopathology; D013132:Spinocerebellar Degenerations / Q000175:diagnosis / Q000235:genetics* / Q000503:physiopathology