[Role of beta-carotene in the prevention of genotoxic damage in patients undergoing radiotherapy. Monitoring by the micronucleus test in exfoliative cells of the oral cavity].
Radiotherapic treatment of patients with carcinoma usually causes genotoxis damage. This has been studied recently using the test of micronuclei in esfoliated cells. This test presents methodologic advantages in compared with the classic citogenetic analysis and as it is carried out on esfolieted cells from the oral cavity it faithfully reflects the genotoxic damage undergone by the cells of the basal layer of the epitelium. The preliminary result obtained so far have confirmed the anticlastogenic activity of beta-carotene in fact, the frequence of micronuclei in esfolieted cells from the oral cavity in patients undergoing radiotherapy or undergoing treatment with beta-carotene is inferior to that of patients undergoing treatment with beta-carotene is inferior to that of patients undergoing radiotherapy without the subministration of carotenoids. Treatment with carotenoids does not influence the therapeutic efficiency of radiotherapy treatment. Therefore, the results seem to confirm that indirect ossidaction processes are involved in the mechanism of the clastogenic action of radiotherapia. The carotenoids seem to be able to contrast validly this undesirable effect without interfering with the desirable therapeutic effect.
Oldini
C
C
Divisione ORL Ospedale Maggiore di Lodi, MI.
Malusardi
G
G
Grossi
L
L
Chiarelli
G
G
D016587:Antimutagenic Agents / Q000627:therapeutic use*; D002338:Carotenoids / Q000627:therapeutic use*; D004341:Drug Evaluation; D005260:Female; D006258:Head and Neck Neoplasms / Q000532:radiotherapy*; D006801:Humans; D008297:Male; D015162:Micronucleus Tests; D008991:Monitoring, Physiologic; D009061:Mouth Mucosa / Q000166:cytology; D011832:Radiation Injuries / Q000517:prevention & control; D011879:Radiotherapy Dosage; D019207:beta Carotene
D016587:Antimutagenic Agents; D019207:beta Carotene; D002338:Carotenoids
Ruolo del beta-carotene nella prevenzione dei danni genotossici in pazienti sottoposti a radioterapia. Monitoraggio mediante test del micronucleo in cellule esfoliate del cavo orale.