[In situ production of interferon gamma and interleukin 6 by infiltrating cells from human kidney allografts in irreversible rejection. Modulation by cytokines].
Using ELISPOT assays, we detected a significant number of cells secreting interferon-gamma and interleukin 6 among 8 irreversibly rejected kidney allografts compared with normal kidneys. Interleukin 2 increases the frequency of interferon-gamma producing cells and interleukin 4 decreases the frequency of both interferon-gamma and interleukin 6 producing cells.
Merville
P
P
Schering-Plough, Dardilly.
Pouteil-Noble
C
C
Wijdenes
J
J
Potaux
L
L
Touraine
J L
JL
Banchereau
J
J
D003864:Depression, Chemical; D006084:Graft Rejection / Q000276:immunology*; D006801:Humans; D007371:Interferon-gamma / Q000096:biosynthesis*; D007376:Interleukin-2 / Q000494:pharmacology; D015847:Interleukin-4 / Q000494:pharmacology; D015850:Interleukin-6 / Q000096:biosynthesis*; D007668:Kidney / Q000187:drug effects / Q000378:metabolism*; D016030:Kidney Transplantation / Q000379:methods*; D013268:Stimulation, Chemical
D007376:Interleukin-2; D015850:Interleukin-6; D015847:Interleukin-4; D007371:Interferon-gamma
Production in situ d'interféron gamma et d'interleukine 6 par les cellules infiltrant des allogreffes rénales humaines en rejet irréversible. Modulation par les cytokines.