title: [Immunopharmacokinetics of synthetic beta-carotene].
abstract: The immunopharmacology and pharmacokinetics of synthetic beta-carotene were studied in complex clinico-laboratory investigations after single and repeated per os administrations of various doses of the drug to healthy volunteers and cancer patients. Repeated treatment with beta-carotene at a dose of 30 mg caused no significant changes in the immunological parameters studied. However, treatment with a dose of 250 mg altered the parameters as follows: alteration of beta-carotene content in blood, elevation of the counts of lymphocytes and T lymphocytes forming "active" rosettes, increase in the proliferative response of lymphocytes to the mitogen PWM and activation of natural killers. Single administration of the drug in a dose of 1,000 and 2,000 mg led to short-term reversible immunodepression, appeared as leukopenia, abolition of the proliferative response of lymphocytes to mitogens and inhibition of T suppressors. Kinetics of retinoids and beta-carotene content in blood plasma was studied after single per os administration of drug megadoses.
authors.forename: A V
authors.initials: AV
authors.lastname: Sergeev
authors.forename: V S
authors.initials: VS
authors.lastname: Anan'ev
authors.forename: L A
authors.initials: LA
authors.lastname: Vakulova
authors.forename: T A
authors.initials: TA
authors.lastname: Zhidkova
authors.forename: Sh K
authors.initials: ShK
authors.lastname: Mukhammedzhanov
authors.forename: R Iu
authors.initials: RIu
authors.lastname: Ramanauskaĭte
authors.forename: V N
authors.initials: VN
authors.lastname: Tolkachev
mesh_terms: D000328:Adult; D002338:Carotenoids / Q000493:pharmacokinetics* / Q000494:pharmacology / Q000627:therapeutic use; D002455:Cell Division / Q000187:drug effects; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009369:Neoplasms / Q000188:drug therapy / Q000276:immunology; D012397:Rosette Formation; D013601:T-Lymphocytes / Q000166:cytology / Q000187:drug effects / Q000276:immunology*; D019207:beta Carotene
chemical_list: D019207:beta Carotene; D002338:Carotenoids
vernacular_title: Immunofarmakokinetika sinteticheskogo beta-karotina.