[The antiepileptic effects of sodium valproate and the calcium antagonist riodipine when used jointly in a model of generalized korazol-induced epileptic activity].
In experiments on male Wistar rats on the model of generalized pentylenetetrazol-induced epileptic activity the efficacy of the combination of the drugs influencing different mechanisms of epileptogenesis: sodium valproate enhancing GABA-ergic processes and calcium antagonist, ryodipine (1,4-dihydropyridine), have been studied. Sodium valproate and ryodipine when used in combination at relatively small doses (70 and 0.75 mg/kg, respectively) produced more marked antiepileptic effect than each of these drugs given alone. The results obtained suggest that complex pathogenetic therapy (CPT) as a combination of antiepileptic drugs acting on corresponding basic mechanisms of respective form of epilepsy is reasonable to be used. According to our previous results, CPT can reduce the risk of side effects of each drug due to decreased doses. CPT may be of great importance in case of long-term treatment.
Kryzhanovskiĭ
G N
GN
Karpova
M N
MN
Pankov
O Iu
OIu
Abramova
E M
EM
Abrosimov
I Iu
IIu
D000818:Animals; D002121:Calcium Channel Blockers / Q000627:therapeutic use*; D004195:Disease Models, Animal; D004305:Dose-Response Relationship, Drug; D004353:Drug Evaluation, Preclinical; D004357:Drug Synergism; D004359:Drug Therapy, Combination; D004829:Epilepsy, Generalized / Q000139:chemically induced / Q000188:drug therapy*; D008297:Male; D009543:Nifedipine / Q000031:analogs & derivatives* / Q000627:therapeutic use; D010433:Pentylenetetrazole; D051381:Rats; D017208:Rats, Wistar; D014635:Valproic Acid / Q000627:therapeutic use*
D002121:Calcium Channel Blockers; D014635:Valproic Acid; D009543:Nifedipine; C045912:ryodipine; D010433:Pentylenetetrazole
Antiépilepticheskie éffekty val'proata natriia i antagonista kal'tsiia riodipina pri ikh sochetannom primenenii na modeli generalizovannoĭ épilepticheskoĭ aktivnosti.