title: [Role of oxygen free radicals in the physiopathology of rheumatoid arthritis].
abstract: The authors present a review of the mechanisms of free radicals production and report the results of "in vivo" and "in vitro" studies correlating these agent with the physiopathologic changes of the rheumatoid arthritis. The data reviewed in this paper support the idea of the participation of free radicals in the articular lesion. However new studies are necessary to determine the contribution of free radicals on disease development, chronicity and the efficacy of antioxidant agents.
authors.forename: I M
authors.initials: IM
authors.lastname: Laurindo
authors.forename: S B
authors.initials: SB
authors.lastname: de Mello
authors.forename: W
authors.initials: W
authors.lastname: Cossermelli
mesh_terms: D000893:Anti-Inflammatory Agents; D001172:Arthritis, Rheumatoid / Q000378:metabolism / Q000473:pathology / Q000503:physiopathology*; D005609:Free Radicals; D006801:Humans; D017382:Reactive Oxygen Species
chemical_list: D000893:Anti-Inflammatory Agents; D005609:Free Radicals; D017382:Reactive Oxygen Species
vernacular_title: Participação dos radicais livres de oxigênio na fisiopatologia da artrite reumatóide.