[Detoxifying effect of antibiotics and their effectiveness in experimental plague at the stage of explicit intoxication].
The effect of antibiotics such as amikacin, rifampicin, doxycycline, polymyxin B and cefotaxime on the toxins of the plague microbe (lipopolysaccharide + fraction II according to Beiker) was studied in vitro and in vivo. The study on the antibiotic neutralization of plague toxins revealed that only polymyxin had toxin neutralizing capacity which depended on the dose. Investigation of the polymyxin effect at various stages of plague infection showed that when polymyxin in a dose of 1250 units and a mixture of plague toxins in lethal doses were administered simultaneously to albino mice, the positive effect amounted to 100 per cent. When the antibiotic was administered 30 or 60 minutes later, the antibiotic efficacy proved to be lower by 90 or 76.6 per cent, respectively. The intoxication in later periods (in 90-120 minutes) resulted in a decrease in animal survival up to 40-15 per cent. It was demonstrated on the model of the plague infection in albino mice that the use of amikacin, cefotaxime, rifampicin or doxycycline during polymyxin therapy at the stage of marked generalization of the infection provided a significant increase in the animal survival (60 to 80 per cent) as compared to that after the use of the same drugs alone (0 to 20 per cent).
Makarovskaia
L N
LN
Glian'ko
E V
EV
Tinker
L A
LA
Kasatkin
Iu A
IuA
Ryzhkova
V V
VV
Bozhko
N V
NV
Kozyreva
L A
LA
D000818:Animals; D000900:Anti-Bacterial Agents / Q000494:pharmacology / Q000627:therapeutic use*; D006168:Guinea Pigs; D051379:Mice; D010930:Plague / Q000188:drug therapy*
D000900:Anti-Bacterial Agents
Detoksitsiruiushchee deĭstvie antibiotikov i ikh éffektivnost' pri éksperimental'noĭ chume na stadii vyrazhennoĭ intoksikatsii.