[The hemodynamic and metabolic effects of 2-deoxy-D-glucose in waking Wistar rats].
The effect of 2-deoxy-D-glucose (2-DG) in a dose of 250 mg/kg as a stressogenic factor on changes in hemodynamic parameters and metabolism in awake rats was quantified during 6 hours. It was found that a single 2-DG injection causes lowering of blood pressure on min 40 and 120. Heart rate tended to slow down. Diminished glucose concentration in the brain observed on experiment minute 15 induced a number of adaptive reactions in the body. Epinephrine plasma levels increased sharply on min 15 and 40. Norepinephrine concentrations elevated slightly only at the beginning of the experiment. The maximal glucose level in blood plasma was observed on min 40 and 120 and that of lactate 40 min following 2-DG injection. The level of immunoreactive insulin rose. Glucose content in the heart came up sharply on min 15 and 40. Lactate concentration in the heart increased continuously.
Ashirova
O P
OP
Oranovskaia
E V
EV
Pisarenko
O I
OI
Studneva
I M
IM
Kuz'min
A I
AI
Medvedev
O S
OS
D000818:Animals; D001769:Blood / Q000187:drug effects / Q000378:metabolism; D001921:Brain / Q000187:drug effects / Q000378:metabolism; D003847:Deoxyglucose / Q000494:pharmacology*; D006321:Heart / Q000187:drug effects; D006439:Hemodynamics / Q000187:drug effects; D008297:Male; D009206:Myocardium / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar; D013997:Time Factors; D014851:Wakefulness / Q000187:drug effects* / Q000502:physiology
D003847:Deoxyglucose
Gemodinamicheskie i metaboloicheskie éffekty 2-deoksi-D-gliukozy u bodrstvuiushchikh krys.