Presence and significance of some antibodies/autoantibodies in patients with acute myocardial infarction and idiopathic dilated cardiomyopathy.
By using ELISA technique we determined the anti-myosin, actin, collagen type I and IV, cholesterol and phosphotyrosine proteins antibodies in sera from patients with acute myocardial infarction and idiopathic dilated cardiomyopathy. In idiopathic dilated cardiomyopathy we found a significant increase in five out of six types of antibodies tested. The patients with acute myocardial infarction reveal high levels of anti-myosin antibodies only. Our results suggest that some of the autoantibodies studied by us have a prognostic value and could be involved in maintaining cardiac dysfunctions.
Matache
C
C
Cantacuzino Institute, Bucharest, Romania.
Stefănescu
M
M
Ivanov
D
D
Szegli
G
G
Popescu
P
P
Filip
Z
Z
D000199:Actins / Q000276:immunology; D000906:Antibodies / Q000097:blood*; D001323:Autoantibodies / Q000097:blood*; D002311:Cardiomyopathy, Dilated / Q000276:immunology*; D002784:Cholesterol / Q000276:immunology; D003094:Collagen / Q000276:immunology; D004797:Enzyme-Linked Immunosorbent Assay; D006801:Humans; D009203:Myocardial Infarction / Q000276:immunology*; D009206:Myocardium / Q000276:immunology*; D009218:Myosins / Q000276:immunology; D019000:Phosphotyrosine; D014443:Tyrosine / Q000031:analogs & derivatives / Q000276:immunology
D000199:Actins; D000906:Antibodies; D001323:Autoantibodies; D019000:Phosphotyrosine; D014443:Tyrosine; D003094:Collagen; D002784:Cholesterol; D009218:Myosins