[Xenobiotic-metabolizing enzymes in rat liver and small intestinal mucosa with varying combinations of polyunsaturated omega-6 and omega-3 fatty acids in the diet].
Male Wistar rats were fed for 30 days semi-synthetic diets containing lard, corn oil or fish oil (ichthynic oil from herring muscles), differing in total content of saturated and polyunsaturated fatty acids (PUFA), in the ratio omega 6/omega 3 PUFA and in content of vitamin E. The activity of xenobiotic metabolizing enzymes was similar in liver of rats fed diets with lard or corn oil, while activities of epoxide hydrolase and UDP-glucuronosyltransferase were significantly higher if fish oil was used. The type of fat affected also the benzyl-produced induction of the enzymes. Differences in the enzyme activities observed did not depend on content of vitamin E in dietary fats. Unlike liver tissue, activities of microsomal enzymes were not considerably altered in rat small intestine in various experimental groups. The microsomal lipids of liver tissue and small intestine mucosal membrane were similar in the total content of saturated and unsaturated fatty acids in various animal groups but the level of omega 6 and omega 3 PUFA in the tissues depended on the ratio omega 6/omega 3 PUFA in diets.
Kravchenko
L V
LV
Kuz'mina
E E
EE
Avren'eva
L I
LI
Kulakova
S N
SN
Levachev
M M
MM
Tutel'ian
V A
VA
D015660:7-Alkoxycoumarin O-Dealkylase / Q000378:metabolism; D000818:Animals; D043182:Carboxylesterase; D002265:Carboxylic Ester Hydrolases / Q000378:metabolism; D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism; D004042:Dietary Fats, Unsaturated / Q000008:administration & dosage*; D004851:Epoxide Hydrolases / Q000378:metabolism; D015525:Fatty Acids, Omega-3 / Q000008:administration & dosage*; D043371:Fatty Acids, Omega-6; D005231:Fatty Acids, Unsaturated / Q000008:administration & dosage*; D014453:Glucuronosyltransferase / Q000378:metabolism; D005982:Glutathione Transferase / Q000378:metabolism; D007413:Intestinal Mucosa / Q000201:enzymology*; D007421:Intestine, Small / Q000201:enzymology*; D008297:Male; D008862:Microsomes, Liver / Q000201:enzymology* / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar; D015262:Xenobiotics / Q000378:metabolism*
D004042:Dietary Fats, Unsaturated; D015525:Fatty Acids, Omega-3; D043371:Fatty Acids, Omega-6; D005231:Fatty Acids, Unsaturated; D015262:Xenobiotics; D003577:Cytochrome P-450 Enzyme System; D015660:7-Alkoxycoumarin O-Dealkylase; D014453:Glucuronosyltransferase; D005982:Glutathione Transferase; D002265:Carboxylic Ester Hydrolases; D043182:Carboxylesterase; D004851:Epoxide Hydrolases
Fermenty metabolizma ksenobiotikov pecheni i slizistoĭ obolochki tonkoĭ kishki drys pri razlichnykh sochetaniiakh polinenasyshchennykh zhirnykh kislot omega 6 i omega 3 v ratsione.