title: Experiences with functional insulin substitution: a follow-up study on control and patient compliance.
abstract: Functional insulin substitution, an insulin regimen made up of two daily injections of intermediate-acting insulin and prandial boluses of regular insulin, was to be introduced in 49 type 1 diabetic patients, as previous regimens consisting of two or three daily injections proved to be inefficient due to the patients lifestyle or inherent metabolic lability. Forty-five patients were treated with human insulin injected by NovoPen. In 38 cases therapy was changed in the frame of a one-week, small-group, inpatient, structured educational course. After a mean 14 months of follow-up metabolic status improved in 33 cases while there was further derangement in 16. Eighteen patients were practising true functional therapy, i.e. doing blood glucose tests before each injection. Further 22 diabetics were trying to achieve better metabolic control through 2-3 daily blood glucose tests and insulin dose corrections. The metabolic status was not affected by the frequency of blood glucose testing, rather by raising of the daily dose of short acting insulin in conjunction with the switch in therapy acting beneficially. All patients insisted on using NovoPen further on.
authors.affiliation: B Department of Medicine, Municipal Péterfy Teaching Hospital, Budapest.
authors.forename: J
authors.initials: J
authors.lastname: Fövényi
authors.forename: G
authors.initials: G
authors.lastname: Szövérffy
authors.forename: E
authors.initials: E
authors.lastname: Thaisz
authors.forename: L
authors.initials: L
authors.lastname: Lehotkai
authors.forename: A
authors.initials: A
authors.lastname: Wettstein
mesh_terms: D000328:Adult; D001786:Blood Glucose / Q000378:metabolism; D003922:Diabetes Mellitus, Type 1 / Q000097:blood / Q000188:drug therapy* / Q000523:psychology; D004334:Drug Administration Schedule; D005260:Female; D005500:Follow-Up Studies; D006442:Glycated Hemoglobin / Q000032:analysis; D006801:Humans; D007328:Insulin / Q000008:administration & dosage / Q000627:therapeutic use*; D008019:Life Style; D008297:Male; D010349:Patient Compliance; D010353:Patient Education as Topic; D012044:Regression Analysis
chemical_list: D001786:Blood Glucose; D006442:Glycated Hemoglobin; D007328:Insulin