[Hypotensive effects of safflower yellow in spontaneously hypertensive rats and influence on plasma renin activity and angiotensin II level].
Safflower yellow (SY) is a mixture of chalconoid compounds extracted from Carthamus tinctorius L. Ig SY 1-2 g.kg-1.d-1 lowered the blood pressure of spontaneously hypertensive rats (SHR), for about 1.86-3.86 kPa. Five weeks after administration of SY, the plasma renin activity and angiotensin II level diminished in the SHR experimental groups. These suggest that the decrease of blood pressure is mediated by the renin-angiotensin system.
Liu
F
F
Department of Pharmacology, Xin jing Medical College, Urümuqi.
Wei
Y
Y
Yang
X Z
XZ
Li
F G
FG
Hu
J
J
Cheng
R F
RF
D000804:Angiotensin II / Q000097:blood*; D000818:Animals; D000959:Antihypertensive Agents / Q000494:pharmacology*; D001794:Blood Pressure / Q000187:drug effects*; D002599:Chalcone / Q000031:analogs & derivatives* / Q000494:pharmacology; D006339:Heart Rate / Q000187:drug effects; D006973:Hypertension / Q000097:blood / Q000503:physiopathology; D008297:Male; D051381:Rats; D011918:Rats, Inbred SHR; D012083:Renin / Q000097:blood*
D000959:Antihypertensive Agents; D000804:Angiotensin II; C076422:safflower yellow; D002599:Chalcone; D012083:Renin