Non-quantal acetylcholine release after cholinesterase inhibition in vivo.
After anticholinesterase treatment in vivo, depolarization of the postsynaptic muscle fibre membrane by about 4 mV develops due to non-quantally released acetylcholine from the motor nerve terminal. This conclusion was supported by experiments with the curarization of diaphragm slices from anticholinesterase treated mice during intracellular microelectrode recordings.
Nikolsky
E E
EE
Kazan Medical Institute, Tatarstan.
Oranska
T I
TI
Vyskocil
F
F
D000109:Acetylcholine / Q000096:biosynthesis*; D000818:Animals; D001138:Armin / Q000494:pharmacology*; D002802:Cholinesterases / Q000502:physiology; D004594:Electrophysiology; D005260:Female; D008297:Male; D051379:Mice; D009045:Motor Endplate / Q000187:drug effects*; D012999:Soman / Q000494:pharmacology*
D012999:Soman; D002802:Cholinesterases; D001138:Armin; D000109:Acetylcholine