[A comparative study of met-enkephalin effects on the secretion by murine lymphocytes of antibodies to different antigens].
The influence of met-enkephalin on specific antibody production by lymphocytes from mouse lymph nodes was studied in vitro in productive phase of immune response. It was shown that the peptide did not influence secretion of IgM-antibody to T-independent antigen-trinitrobenzensulfoacidic group, but suppressed secretion of IgG-antibody to T-dependent antigens both during primary and secondary response. The efficiency of superlow concentrations of the peptide (10(-15)-10(-14) M) for the response to ovalbumin, but not for the response to bovine gamma-globulin was shown. All effects of met-enkephalin were naloxone-reversible. The existence of individual distribution in dose-dependences of peptide action on antibody secretion in response to ovalbumin was demonstrated.
Khegaĭ
L A
LA
Zakharova
L A
LA
Gavrilova
E M
EM
Zaĭtsev
S V
SV
D000818:Animals; D000906:Antibodies / Q000032:analysis / Q000187:drug effects*; D000918:Antibody Specificity / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D004744:Enkephalin, Methionine / Q000494:pharmacology*; D005260:Female; D007114:Immunization / Q000379:methods; D008198:Lymph Nodes / Q000187:drug effects / Q000276:immunology; D008214:Lymphocytes / Q000187:drug effects* / Q000276:immunology / Q000378:metabolism; D051379:Mice; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D013997:Time Factors
D000906:Antibodies; D004744:Enkephalin, Methionine
Sravnitel'noe izuchenie éffektov met-énkefalina na sekretsiiu limfotsitami myshi antitel k razlichnym antigenam.