title: Neurofibrillary degeneration and microtubule associated protein tau.
abstract: Alzheimer disease is characterized by neurofibrillary pathology containing paired helical filaments (PHF). These abnormal filaments consist of a modified form of microtubule associated protein tau. The modification involves phosphorylation. In this mini review, we summarize recent studies regarding the differences between normal tau and PHF-tau, focusing especially on the extent and the site of phosphorylation. We also discuss the mechanisms possible involved in the development of PHF.
authors.affiliation: Department of Pathology, Albert Einstein College of Medicine, Bronx New York.
authors.forename: S H
authors.initials: SH
authors.lastname: Yen
authors.forename: W K
authors.initials: WK
authors.lastname: Liu
mesh_terms: D000544:Alzheimer Disease / Q000378:metabolism / Q000473:pathology; D000818:Animals; D006801:Humans; D008870:Microtubules / Q000502:physiology*; D009410:Nerve Degeneration / Q000502:physiology*; D016874:Neurofibrillary Tangles / Q000378:metabolism / Q000473:pathology; D009454:Neurofibrils / Q000502:physiology*; D010766:Phosphorylation; D016875:tau Proteins / Q000502:physiology*
chemical_list: D016875:tau Proteins