[Effect of dibunol on lipid peroxidation and alpha-tocopherol level in the rat heart in acute hemorrhage].
The authors studied the effect of a single injection of dibunol in a dose of 120 mg/kg on lipid peroxidation (LPO) and alpha-tocopherol (TP) level in the heart muscle in acute blood loss. The LPO products and alpha-tocopherol level were determined simultaneously in a heart homogenate 2 hours after the blood loss. It was established that the loss of blood leads to activation of LPO and reduction of the TP level in the myocardium. Dibunol injection inhibited LPO activation, reducing the content of LPO products to that in animals with a false operation (without blood loss), and increased the TP level also to that in a false operation. The decrease of the TP level in acute blood loss depends, evidently, on increased mobilization of TP from the myocardium due to the increased level of catecholamines (CA), while the increase of TP under the effect of dibunol occurs due to its inhibited mobilization from the myocardium, which is mediated by reduction of the CA level.
Matveev
S B
SB
Marchenko
V V
VV
Golikov
P P
PP
D000208:Acute Disease; D000818:Animals; D002084:Butylated Hydroxytoluene / Q000494:pharmacology*; D006321:Heart / Q000187:drug effects*; D006470:Hemorrhage / Q000378:metabolism*; D015227:Lipid Peroxidation / Q000187:drug effects*; D008297:Male; D009206:Myocardium / Q000378:metabolism*; D051381:Rats; D017208:Rats, Wistar; D014810:Vitamin E / Q000378:metabolism*
D014810:Vitamin E; D002084:Butylated Hydroxytoluene
Vliianie dibunola na perekisnoe okislenie lipidov i uroven' alpha-tokoferola v serdtse krys pri ostroĭ krovopotere.