Calcium oscillations in single isolated human vascular smooth muscle cells.
When cultured human vascular smooth muscle cells are exposed to sodium-free solutions oscillations in intracellular calcium concentration are observed. In some cells the oscillations are maintained at constant amplitude throughout the exposure to Na(+)-free solution, in others the amplitude of the oscillations falls to a lower, steady-state level. The oscillations are also activated and maintained in isotonic, Na(+)-free, K+ solutions suggesting that the underlying mechanism does not involve the opening and closing of voltage-dependent channels. The possible mechanisms responsible for this behaviour are discussed.
Otun
H
H
Department of Physiological Sciences Medical School, The University, Newcastle upon Tyne.
Gillespie
J I
JI
Greenwell
J R
JR
Dunlop
W
W
D002118:Calcium / Q000378:metabolism*; D015220:Calcium Channels / Q000378:metabolism; D002478:Cells, Cultured; D006801:Humans; D009131:Muscle, Smooth, Vascular / Q000187:drug effects / Q000378:metabolism*; D011188:Potassium / Q000494:pharmacology; D012964:Sodium / Q000494:pharmacology
D015220:Calcium Channels; D012964:Sodium; D011188:Potassium; D002118:Calcium