[Antimalarial effect of n-hentriacontanol isolated from Cuatresia sp (Solanaceae)].
The antimalarial activity of the fatty alcohol, n-hentriacontanol, isolated from the bolivian Solanaceae, Cuatresia sp, is investigated in vivo through a classical four-day suppressive test against Plasmodium berghei and P. vinckei in mice. This product markedly reduced the virulence of experimentally induced P. vinckei infection. n-Hentriacontanol belongs to a new class of antimalarial natural compounds to be exploited for therapeutic purposes.
Deharo
E
E
IBBA-ORSTOM, La Paz, Bolivie.
Sauvain
M
M
Moretti
C
C
Richard
B
B
Ruiz
E
E
Massiot
G
G
D000818:Animals; D000962:Antimalarials / Q000627:therapeutic use; D001838:Bolivia; D008288:Malaria / Q000188:drug therapy*; D051379:Mice; D010946:Plants, Medicinal; D010961:Plasmodium / Q000187:drug effects; D010962:Plasmodium berghei / Q000187:drug effects
D000962:Antimalarials
Activité antipaludique du n-hentriacontanol isolé de Cuatresia sp (Solanaceae).