title: Specific expression of glutathione S-transferase Pi forms in (pre)neoplastic tissues: their properties and functions.
abstract: The detection of preneoplastic cells is very important for the analysis of carcinogenic processes and for developing strategies for prevention and treatment of cancer. We have been investigating enzyme alterations occurring during rat chemical hepatocarcinogenesis, especially to find more specific enzyme markers for preneoplastic hepatic lesions. We identified the placental form of glutathione S-transferase (GST-P; GST 7-7) as a new marker enzyme for preneoplastic hepatocytes. We also found human placental form, GST-pi, to be a possible tumor marker for various human tissues except liver. In this article, their properties and possible functions are reviewed on basis of our recent investigations. A peroxisomal enzyme, enoyl CoA hydratase, in also described as a possible negative marker for rat preneoplastic hepatic foci/nodules and hepatomas induced by peroxisome proliferators.
authors.affiliation: Second Department of Biochemistry, Hirosaki University School of Medicine, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Sato
authors.forename: K
authors.initials: K
authors.lastname: Satoh
authors.forename: S
authors.initials: S
authors.lastname: Tsuchida
authors.forename: I
authors.initials: I
authors.lastname: Hatayama
authors.forename: H
authors.initials: H
authors.lastname: Shen
authors.forename: Y
authors.initials: Y
authors.lastname: Yokoyama
authors.forename: Y
authors.initials: Y
authors.lastname: Yamada
authors.forename: K
authors.initials: K
authors.lastname: Tamai
mesh_terms: D000818:Animals; D015415:Biomarkers / Q000737:chemistry; D014408:Biomarkers, Tumor / Q000032:analysis; D004351:Drug Resistance / Q000502:physiology; D005982:Glutathione Transferase / Q000032:analysis*; D006801:Humans; D008099:Liver / Q000201:enzymology; D008114:Liver Neoplasms, Experimental / Q000139:chemically induced / Q000201:enzymology; D008830:Microbodies / Q000187:drug effects; D011230:Precancerous Conditions / Q000201:enzymology*; D051381:Rats
chemical_list: D015415:Biomarkers; D014408:Biomarkers, Tumor; D005982:Glutathione Transferase