Relation between thyroid status and ferritin metabolism in rats.
Rats were made hypo and 'hyperthyroid' with propylthiouracil (PTU) and L-Thyroxine (L-T) respectively. The hypo and hyperthyroid status in these rats were confirmed by serum level of T4 and T3. Liver iron was significantly increased in both the hypo and hyperthyroid animals. However, liver ferritin synthesis rate was reduced by 36% in hypothyroid rats, and elevated by 38% in hyperthyroid ones. A similar trend was seen in liver ferritin concentration. Further, serum transaminases were elevated only in animals of the hyperthyroid group. It appears from the present data that ferritin metabolism is influenced by thyroid hormone as well as by iron. Thus, the raised serum ferritin in hyperthyroid patients may be partially attributed to increased ferritin synthesis in the liver and its possible leakage into circulation.
Deshpande
U R
UR
Radiation Medicine Centre, B.A.R.C., Bombay, India.
Nadkarni
G D
GD
D000418:Albumins / Q000096:biosynthesis; D000818:Animals; D005293:Ferritins / Q000096:biosynthesis / Q000378:metabolism*; D006980:Hyperthyroidism / Q000139:chemically induced / Q000378:metabolism; D007037:Hypothyroidism / Q000139:chemically induced / Q000378:metabolism; D007501:Iron / Q000097:blood / Q000378:metabolism; D007700:Kinetics; D008099:Liver / Q000201:enzymology / Q000378:metabolism; D008297:Male; D011441:Propylthiouracil; D051381:Rats; D017208:Rats, Wistar; D013961:Thyroid Gland / Q000502:physiology*; D013963:Thyroid Hormones / Q000502:physiology; D013974:Thyroxine / Q000097:blood; D014284:Triiodothyronine / Q000097:blood
D000418:Albumins; D013963:Thyroid Hormones; D014284:Triiodothyronine; D011441:Propylthiouracil; D005293:Ferritins; D007501:Iron; D013974:Thyroxine