[Effect of inhalation of surface-active substances on the surfactant system of the lung].
Surface activity, biochemical composition and morphology of the rat lungs were studied in norm, under effect of acute hypoxia and after infusion of obsidan (1 mg/100g). The data permit suggesting that under the influence of obsidan and hypoxia a stability index of surfactants and quantity of phospholipids decreased, while the quantity of lysophosphatidylcholine and lysophosphatidylethanolamine increased. Morphology studies show that after hypoxia and obsidan infusion oedema and cell destruction developed in the lung. The inhalation of exogenous surfactant increased stability index and quantity of phospholipids, decreased the quantity of lysophospholipids but did not eliminate morphological disorders in the lung induced by hypoxia and obsidan infusion.
Berezovsky?
V Ia
VIa
Bogomolets
O O
OO
Gorchakov
V Iu
VIu
Palagina
M V
MV
Khasabova
I A
IA
Khasina
M A
MA
D000280:Administration, Inhalation; D000818:Animals; D001273:Atmosphere Exposure Chambers; D015687:Cell Hypoxia; D008168:Lung / Q000187:drug effects* / Q000473:pathology / Q000502:physiology; D008297:Male; D011433:Propranolol / Q000494:pharmacology*; D011663:Pulmonary Surfactants / Q000187:drug effects* / Q000378:metabolism; D011897:Random Allocation; D051381:Rats; D013501:Surface-Active Agents / Q000494:pharmacology*
D011663:Pulmonary Surfactants; D013501:Surface-Active Agents; D011433:Propranolol
Vplyv ingaliatsiĭ poverkhnevo-aktyvnykh rechovyn na stan surfaktantnoĭ systemy legen.