title: [The antiviral action of a modified bacterial ribonuclease].
abstract: The antiviral activity of a bacterial ribonuclease conjugate with chitosane of Kamchatka crab (in a form of water soluble chito-oligosaccharides) has been studied. The conjugate inhibitory activity for A and B viruses as well as to Sindbis arbovirus in tissue cultures is shown. The preparation efficiency at intramuscular and intranasal administration was observed at experimental influenza infection of white mice.
authors.forename: M K
authors.initials: MK
authors.lastname: Indulen
authors.forename: N A
authors.initials: NA
authors.lastname: Zamiatina
authors.forename: V P
authors.initials: VP
authors.lastname: Varlamov
authors.forename: A V
authors.initials: AV
authors.lastname: Il'ina
mesh_terms: D000818:Animals; D000998:Antiviral Agents / Q000494:pharmacology* / Q000627:therapeutic use; D001407:Bacillus / Q000201:enzymology; D003386:Brachyura / Q000201:enzymology; D002686:Chitin / Q000031:analogs & derivatives / Q000494:pharmacology / Q000627:therapeutic use; D048271:Chitosan; D004338:Drug Combinations; D004353:Drug Evaluation, Preclinical; D009980:Influenza A virus / Q000187:drug effects; D009981:Influenza B virus / Q000187:drug effects; D051379:Mice; D009976:Orthomyxoviridae Infections / Q000188:drug therapy; D012260:Ribonucleases / Q000494:pharmacology* / Q000627:therapeutic use; D012845:Sindbis Virus / Q000187:drug effects
chemical_list: D000998:Antiviral Agents; D004338:Drug Combinations; D002686:Chitin; D048271:Chitosan; D012260:Ribonucleases
vernacular_title: Izuchenie antivirusnogo deĭstviia modifitsirovannoĭ bakterial'noĭ ribonukleazy.