title: Biologic relevance of elevated red cell adenosine deaminase activity in myelodysplastic syndromes and paroxysmal nocturnal hemoglobinuria.
abstract: Red cell adenosine deaminase (ADA-RBC) activity in patients with myelodysplastic syndromes and paroxysmal nocturnal hemoglobinuria is significantly increased compared to that observed in normal controls. ADA-RBC activity is not related to fetal hemoglobin concentration, but it is significantly correlated with hemoglobin concentration at diagnosis and with the degree of morphologic dysplasia in the erythroid lineage. The results of our study suggest that the observed enzymatic abnormality may constitute a non-specific manifestation of the stem cell alteration that determines these disorders.
authors.affiliation: Cattedra di Ematologia, Università di Palermo, Italy.
authors.forename: P
authors.initials: P
authors.lastname: di Marco
authors.forename: D
authors.initials: D
authors.lastname: Tinnirello
authors.forename: M
authors.initials: M
authors.lastname: Tambone-Reyes
authors.forename: L
authors.initials: L
authors.lastname: Tedesco
authors.forename: S
authors.initials: S
authors.lastname: Luna
authors.forename: P
authors.initials: P
authors.lastname: Citarella
mesh_terms: D000243:Adenosine Deaminase / Q000097:blood*; D000328:Adult; D000368:Aged; D004912:Erythrocytes / Q000201:enzymology*; D005260:Female; D006457:Hemoglobinuria, Paroxysmal / Q000201:enzymology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009190:Myelodysplastic Syndromes / Q000201:enzymology*; D011289:Preleukemia / Q000201:enzymology
chemical_list: D000243:Adenosine Deaminase