Methylprednisolone reduces the nephrotoxicity caused by cisplatin.
Male Sprague-Dawley rats were given either 6.5 or 8.5 mg/kg of iv cisplatin combined with three injections of sc methylprednisolone in doses of either 50, 100 or 250 mg/kg at -4, 0 and 4 h after the cisplatin injection. Blood urea nitrogen and serum creatinine levels were determined on day 5 following the cisplatin injection. The protective effects of methylprednisolone on cisplatin-induced nephrotoxicity were clearly demonstrated. Our preliminary results suggest that a much higher dose of cisplatin could be injected in cancer chemotherapy, if it was combined with methylprednisolone.
Uozumi
J
J
Department of Urology, Faculty of Medicine, Kyushu University, Fukuoka, Japan.
Koikawa
Y
Y
Ueda
T
T
D000818:Animals; D001806:Blood Urea Nitrogen; D002945:Cisplatin / Q000008:administration & dosage / Q000633:toxicity*; D003404:Creatinine / Q000097:blood*; D004347:Drug Interactions; D007275:Injections, Intravenous; D007279:Injections, Subcutaneous; D007668:Kidney / Q000187:drug effects*; D008297:Male; D008775:Methylprednisolone / Q000008:administration & dosage / Q000494:pharmacology*; D051381:Rats; D017207:Rats, Sprague-Dawley
D003404:Creatinine; D002945:Cisplatin; D008775:Methylprednisolone