Increased expression of the 67kDa-laminin receptor gene in human small cell lung cancer.
Gene expression of the precursor of the 67kDa-laminin receptor was examined by Northern analysis using 11 established human lung cancer cell lines and 25 lung cancer tissues obtained by operation. As a result, one transcript, the size of which was 1.2 kb was shown in all cell lines and tissues examined. An increased level of mRNA was demonstrated in cell lines which proliferated rapidly and in small cell lung cancer cell lines. It was also indicated that gene expression of the laminin receptor was up-regulated especially in small cell lung cancer tissue. In this context, 67kDa-laminin receptor appears to be a marker for biological aggressiveness of human lung cancer.
Satoh
K
K
Department of Internal Medicine, Tohoku University, Sendai, Japan.
Narumi
K
K
Isemura
M
M
Sakai
T
T
Abe
T
T
Matsushima
K
K
Okuda
K
K
Motomiya
M
M
D000230:Adenocarcinoma; D015152:Blotting, Northern; D018288:Carcinoma, Small Cell; D002294:Carcinoma, Squamous Cell; D002455:Cell Division; D002460:Cell Line; D003001:Cloning, Molecular; D015870:Gene Expression; D015723:Gene Library; D006801:Humans; D007700:Kinetics; D007797:Laminin / Q000378:metabolism; D008175:Lung Neoplasms; D008970:Molecular Weight; D012333:RNA, Messenger / Q000032:analysis / Q000235:genetics* / Q000378:metabolism; D011971:Receptors, Immunologic / Q000235:genetics*; D017474:Receptors, Laminin
D007797:Laminin; D012333:RNA, Messenger; D011971:Receptors, Immunologic; D017474:Receptors, Laminin