[The evaluation of the possibility of using prodigiozan for isolating extracts that stimulate proliferative processes in the resected liver].
The experiments were performed on 126 white male rats. The inclusion of 3H-thymidine in nuclear DNA of the liver was studied on h 24 and 48 after 70% resection of the liver versus prodigiosan injection or combination of prodigiosan with 70% resection of the liver. Liver extracts stimulating proliferation (ESP) obtained under the above schedules were studied on the model of 30% liver resection. It is shown that prodigiosan (0.25 mg/kg) injected to intact rats and rats with 70% resected liver initiated ESP production promoting the inclusion of 3H-thymidine in nuclear DNA of the liver after 30% resection of the liver.
Fedorova
L M
LM
Arkhangel'skaia
S L
SL
Bilenko
M V
MV
D000818:Animals; D002455:Cell Division / Q000187:drug effects; D004247:DNA / Q000096:biosynthesis / Q000187:drug effects; D006498:Hepatectomy; D008099:Liver / Q000166:cytology / Q000187:drug effects* / Q000378:metabolism; D008115:Liver Regeneration / Q000187:drug effects*; D008297:Male; D011354:Prodigiozan / Q000494:pharmacology*; D051381:Rats; D013268:Stimulation, Chemical; D013997:Time Factors; D014020:Tissue Extracts / Q000302:isolation & purification* / Q000494:pharmacology; D014316:Tritium
D014020:Tissue Extracts; D014316:Tritium; D004247:DNA; D011354:Prodigiozan
Otsenka vozmozhnosti ispol'zovaniia prodigiozana dlia vydeleniia ékstraktov, stimuliruiushchikh proliferativnye protsessy v rezetsirovannoĭ pecheni.