[Autoantibodies against the beta 1-adrenergic receptor in myocarditis and dilated cardiomyopathy: localization of two epitopes].
Sera of patients with myocarditis and dilated cardiomyopathy contain stimulatory autoantibodies directed specifically against the beta 1-adrenergic receptor. The binding of the antibodies could be localized to either the first or the second extracellular loop of the beta 1-adrenoceptor. In 73% of the cases investigated the antibodies recognized the second extracellular loop. The agonistic effects of the antibodies were abolished by beta-adrenergic antagonists. Furthermore, the antagonists were able to remove the antibodies from their binding sites.
Wallukat
G
G
Max Delbrück Centrum für molekulare Medizin, Berlin.
Morwinski
R
R
Magnusson
Y
Y
Hoebeke
J
J
Wollenberger
A
A
D000319:Adrenergic beta-Antagonists / Q000494:pharmacology; D000818:Animals; D001323:Autoantibodies / Q000032:analysis*; D001666:Binding Sites, Antibody / Q000187:drug effects / Q000276:immunology; D002311:Cardiomyopathy, Dilated / Q000276:immunology*; D002478:Cells, Cultured; D000939:Epitopes / Q000276:immunology*; D006339:Heart Rate / Q000187:drug effects / Q000502:physiology; D006801:Humans; D009200:Myocardial Contraction / Q000187:drug effects / Q000502:physiology; D009205:Myocarditis / Q000276:immunology*; D009206:Myocardium / Q000276:immunology; D051381:Rats; D017208:Rats, Wistar; D011943:Receptors, Adrenergic, beta / Q000187:drug effects / Q000276:immunology*
D000319:Adrenergic beta-Antagonists; D001323:Autoantibodies; D000939:Epitopes; D011943:Receptors, Adrenergic, beta
Autoantikörper gegen den beta 1-adrenergen Rezeptor bei Myokarditis und dilatativer Kardiomyopathie: Lokalisation von zwei Epitopen.