[Nephrotoxic effect of gentamicin on the function of the proximal tubules of the nephron and glomerular filtration].
The purpose of the study was assessment of gentamicin nephrotoxicity with reference to proximal tubule function and glomerular filtration. The study was carried out in 20 patients with nephrolithiasis and chronic pyelonephritis, and 33 patients with respiratory and bile tract infections treated with gentamicin in doses of 2-3 mg/kg/2 h. In 3 patients with nephrolithiasis and chronic pyelonephritis signs of increased nephrotoxicity of gentamicin (according to Schentag criteria) were found. Similar signs were demonstrated in 3 patients with non-urinary tract infections. The abnormalities included increased excretion of low-molecular protein and beta-2-microglobulin (B2m), reduction of B2m reabsorption and lower glomerular filtration. Beta-2-microglobulinuria increase precede by 4-5 days the fall of the glomerular filtration rate which suggests that beta-2-microglobulinuria assessment is an early sign of gentamicin neurotoxicity.
Pupek-Musialik
D
D
Kliniki Nadciśnienia Tetniczego Instytutu Kardiologii Ak. Med., Poznaniu.
D000328:Adult; D004927:Escherichia coli Infections / Q000188:drug therapy* / Q000503:physiopathology; D005260:Female; D005839:Gentamicins / Q000627:therapeutic use / Q000633:toxicity*; D005919:Glomerular Filtration Rate / Q000187:drug effects* / Q000502:physiology; D006801:Humans; D007687:Kidney Tubules, Proximal / Q000187:drug effects* / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D011704:Pyelonephritis / Q000188:drug therapy* / Q000503:physiopathology; D013268:Stimulation, Chemical; D001613:beta 2-Microglobulin / Q000652:urine*
D005839:Gentamicins; D001613:beta 2-Microglobulin
Nefrotoksyczny wpływ gentamycyny na funkcje cewki proksymalnej nefronu i przesaczanie kłebkowe.