[Secretion of hCG by mononuclear cells--a specific and essential reaction in pregnancy?].
Mononuclear cells in peripheral blood secrete immunoreactive hCG (ir-hCG) when they are stimulated in in-vitro culture with the proteinkinase C - activator phorbol-myristat-acetate (TPA). We examined the ir-hCG secretion in 61 fertile and 191 pregnant women and 38 men. Mononuclear cells of pregnant women secrete after TPA stimulation significantly more ir-hCG than mononuclear cells on non-pregnant but fertile women. This effect can be detected as early as 23rd days of a menstrual cycle which is accompanied by conception and persisted over the entire duration of a pregnancy. Maximal effects were observed in the 7th to 19th and 30th to 34th weeks of pregnancy. An artefact caused by adhesive serum-hCG could be excluded. The elevated potential of the mononuclear cells to be stimulated remained intact for about 14 days after termination of a normal pregnancy in the first trimester. An ir-hCG secretion similar to that seen in nonpregnant women was found in patients with early abortion. The possible physiological importance of the in-vivo secretion of beta-HCG during pregnancy is discussed.
Alexander
H
H
Klinik für Gynäkologie und Geburtshilfe der Universität Leipzig.
Giese
T
T
Metzner
G
G
Lehmann
M
M
Zimmermann
G
G
Pfeiffer
R
R
Henke
O
O
Pretzsch
G
G
D000027:Abortion, Incomplete / Q000097:blood; D000028:Abortion, Induced; D006063:Chorionic Gonadotropin / Q000097:blood*; D005260:Female; D005865:Gestational Age; D006801:Humans; D007963:Leukocytes, Mononuclear / Q000502:physiology*; D008297:Male; D011247:Pregnancy / Q000502:physiology*
D006063:Chorionic Gonadotropin
Sekretion von hCG durch mononukleäre Zellen--eine spezifische und essentielle Reaktion während der Schwangerschaft?