title: Issues related to dust aerosols in the magnesite industry. II. Environmental exposure.
abstract: Magnesite waste containing largely magnesium oxide (MgO) and a mixture of other metals forms aerosols with a considerable portion of respirable particles when released into the atmosphere. Several animal species (domestic rabbits, Wistar rats, cattle) were used to biologically monitor the accumulation and effects of inhaled magnesite aerosol in two actual locations of the magnesite industry. The study revealed the biological accumulation of magnesium, iron and other metals in the bodies of exposed animals (and F1 animals) as well as specific lesions on tracheal relief, morphological changes in organ microstructure (especially in the lungs, spleen, liver and myocardium), alternations in the reproductive capacity of females, distorted Mg:Ca:P ratio as well as changes in the immune profile. The findings of biological monitoring of animals are consistent with the conclusions of epidemiological studies.
authors.affiliation: Institute of Ecobiology, Slovak Academy of Sciences, Bratislava, Czechoslovakia.
authors.forename: E
authors.initials: E
authors.lastname: Reichrtová
authors.forename: L
authors.initials: L
authors.lastname: Takác
mesh_terms: D000818:Animals; D002417:Cattle; D003604:Czechoslovakia; D004781:Environmental Exposure / Q000032:analysis*; D004784:Environmental Monitoring / Q000379:methods; D005260:Female; D007109:Immunity / Q000187:drug effects; D008099:Liver / Q000378:metabolism; D008168:Lung / Q000378:metabolism; D008274:Magnesium / Q000009:adverse effects / Q000493:pharmacokinetics*; D008297:Male; D009132:Muscles / Q000378:metabolism; D011817:Rabbits; D051381:Rats; D017208:Rats, Wistar; D012098:Reproduction / Q000187:drug effects; D014132:Trachea / Q000166:cytology / Q000187:drug effects
chemical_list: C005479:magnesium carbonate; D008274:Magnesium