Rare earth metal ions for unprecedentedly fast RNA hydrolysis.
Adenylyl(3'-5')adenosine (ApA) and uridyl(3'-5')uridine (UpU) are hydrolyzed at unprecedentedly large rates by rare earth metal ions at pH 8, 30 degrees C. With 0.01 M Tm(III), the half-lives are 10 min and 51 min, respectively. Potentiality of these ions as catalytic center of artificial ribonuclease is proposed.
Matsumura
K
K
Department of Industrial Chemistry, Faculty of Engineering, University of Tokyo, Japan.
Matsumoto
Y
Y
Komiyama
M
M
D002384:Catalysis; D015226:Dinucleoside Phosphates / Q000737:chemistry; D006868:Hydrolysis; D007700:Kinetics; D008674:Metals, Rare Earth / Q000737:chemistry*; D012313:RNA / Q000737:chemistry*
D015226:Dinucleoside Phosphates; D008674:Metals, Rare Earth; C006412:adenylyl-(3'-5')-adenosine; C026519:uridine monophosphate-uridine; D012313:RNA