[Clinical effect of proton pump inhibitors on reflux esophagitis].
The clinical efficacy of proton pump inhibitors (PPI, omeprazole 20 mg or lansoprazole 30 mg), once daily, after breakfast, was studied in patients with erosive/ulcerative reflux esophagitis. The following results were obtained. 1) Twenty-four hour esophageal pH monitoring was performed before treatment and on 7th day of PPI medications. Omeprazole reduced the percent time pH less than 4 from 29.1 to 1.2 and lansoprazole from 68.0 to 2.4. 2) The cumulative disappearance rate of overall symptom was 52% after 1 week and 62% after 2 weeks with omeprazole these were 66% and 91%, and with lansoprazole respectively 3) The endoscopic healing rate was 63% was after 2 weeks and 76% after 4 weeks with omeprazole medication, and 76% and 97% respectively with lansoprazole. These results indicate that PPI medication inhibits the acid reflux almost completely and is a more useful therapeutic agent for GERD than H2-antagonists.
Sekiguchi
T
T
First Department of Internal Medicine, Gunma University School of Medicine.
Horikoshi
T
T
Nishioka
T
T
Kusano
M
M
D053799:2-Pyridinylmethylsulfinylbenzimidazoles; D000251:Adenosine Triphosphatases / Q000037:antagonists & inhibitors*; D004942:Esophagitis, Peptic / Q000188:drug therapy* / Q000473:pathology / Q000503:physiopathology; D004945:Esophagoscopy; D004947:Esophagus / Q000503:physiopathology; D017506:H(+)-K(+)-Exchanging ATPase; D006801:Humans; D006863:Hydrogen-Ion Concentration; D064747:Lansoprazole; D008991:Monitoring, Physiologic; D009853:Omeprazole / Q000031:analogs & derivatives* / Q000494:pharmacology / Q000627:therapeutic use*; D013997:Time Factors
D053799:2-Pyridinylmethylsulfinylbenzimidazoles; D064747:Lansoprazole; D000251:Adenosine Triphosphatases; D017506:H(+)-K(+)-Exchanging ATPase; D009853:Omeprazole