The determination of the preservative, chlorocresol, in a pharmaceutical formulation by flow injection analysis.
A flow injection analysis (FIA) procedure is described for the determination of chlorocresol in a parenteral pharmaceutical formulation. The product is directly injected into a carrier stream of water and subsequently reacted with a reagent stream of nitrous acid. The resulting brown nitro-derivative is determined spectrophotometrically at 400 nm. The method has been validated and should be applicable to chlorocresol in other pharmaceutical products and to compounds containing a phenolic ring, assuming absence of matrix interference.
Bloomfield
M S
MS
Analytical Development Laboratory, Wellcome Foundation Limited, Dartford, Kent, UK.
Prebble
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KA
D002626:Chemistry, Pharmaceutical / Q000379:methods*; D003408:Cresols / Q000032:analysis*; D017022:Flow Injection Analysis; D019800:Phenol; D010636:Phenols / Q000032:analysis; D011310:Preservatives, Pharmaceutical / Q000032:analysis*; D015203:Reproducibility of Results; D013056:Spectrophotometry, Ultraviolet
D003408:Cresols; D010636:Phenols; D011310:Preservatives, Pharmaceutical; D019800:Phenol; C006984:chlorocresol