c-fos mRNA in mouse brain after MPTP treatment.
The neurotoxin, MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine) induces a transient increase of mRNA for the immediate-early gene c-fos in the mouse brain. The c-fos mRNA level is MPTP dose-dependent and is evident in all brain regions tested including striatum, hypothalamus, cortex, hippocampus, cerebellum and midbrain. There are regional differences in the time-course for the rise of c-fos mRNA. Pretreatment with deprenyl, a selective monoamine oxidase B inhibitor, pargyline, a nonselective monoamine oxidase inhibitor, or mazindol, a dopamine uptake transport inhibitor, does not prevent the c-fos mRNA increase, suggesting that the elevation is due to the action of MPTP and not its neurotoxic metabolite MPP+.
Duchemin
A M
AM
Department of Pharmacology, Ohio State University College of Medicine, Columbus 43210.
Gudehithlu
K P
KP
Neff
N H
NH
Hadjiconstantinou
M
M
D015632:1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine / Q000494:pharmacology*; D000818:Animals; D015152:Blotting, Northern; D001921:Brain / Q000187:drug effects / Q000378:metabolism*; D004305:Dose-Response Relationship, Drug; D016762:Genes, fos; D007700:Kinetics; D008297:Male; D008454:Mazindol / Q000494:pharmacology; D051379:Mice; D009498:Neurotoxins / Q000494:pharmacology*; D009928:Organ Specificity; D010293:Pargyline / Q000494:pharmacology; D012313:RNA / Q000302:isolation & purification; D012333:RNA, Messenger / Q000378:metabolism*; D012016:Reference Values; D012642:Selegiline / Q000494:pharmacology; D013997:Time Factors
D009498:Neurotoxins; D012333:RNA, Messenger; D012642:Selegiline; D012313:RNA; D010293:Pargyline; D015632:1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; D008454:Mazindol