title: [Oat bran as lipid-lowering agent?].
abstract: Hypercholesterolemia is one of the major risk factors for ischemic heart disease and for the development of atherosclerotic plaques. Water soluble plant fibers do exert a binding of intestinal cholesterol and are not digested or metabolized. We have investigated the effect of a highly water soluble fiber containing oat brain on serum cholesterol concentrations in 14 volunteers (nine males, five females, age 39 to 67 years, serum cholesterol concentration: 7.14 +/- 0.80 mmol/l; x +/- SD) during an intervention with 50 g oat brain per day for nine weeks. We have documented in the whole study population a modest, but significant reduction of serum cholesterol levels of 4.2% (p less than 0.05) at six weeks; however at nine weeks the efficacy of this regimen was less pronounced (3.2%, p = n.s.) speaking for a decreased compliance although this regimen was well tolerated and accepted. In subsets of high risk volunteers for coronary heart disease of male gender (n = 9), with hypercholesterolemia (n = 8) or essential hypertension (n = 8) the reduction of serum cholesterol levels was more consistent (5.6%, p less than 0.05) with no change in normolipemic volunteers.
authors.affiliation: Dept. Innere Medizin, Medizinische Universitäts-Poliklinik, Kantonsspital, Basel.
authors.forename: M
authors.initials: M
authors.lastname: Longauer
authors.forename: P
authors.initials: P
authors.lastname: Erne
authors.forename: E
authors.initials: E
authors.lastname: Schmidt
authors.forename: E
authors.initials: E
authors.lastname: Bürgisser
authors.forename: U C
authors.initials: UC
authors.lastname: Dubach
mesh_terms: D000328:Adult; D000368:Aged; D002784:Cholesterol / Q000097:blood; D004043:Dietary Fiber; D002523:Edible Grain; D005260:Female; D006266:Health Education; D006801:Humans; D006937:Hypercholesterolemia / Q000188:drug therapy*; D006949:Hyperlipidemias / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies
chemical_list: D004043:Dietary Fiber; D002784:Cholesterol
vernacular_title: Haferkleie als Lipidesenker?