In vitro study of rat uterus after chronic formaldehyde exposure.
To measure cholinergic, adrenergic and tryptaminergic receptor activity of formaldehyde (HCHO) in rat uterus, albino rats were treated with 5 and 10 mg/kg, ip HCHO for 30 days. Acetylcholine (ACh) in doses 1.33, 2 and 3 micrograms/ml produced mild to moderate contraction of isolated rat uterus in control group. HCHO had no effect on isolated rat uterus per se, however it reduced ACh and carbachol induced contraction and presence of adrenaline influences in respect of ACh and carbachol activity. Adrenaline per se had no effect in control preparations, but reduced carbachol induced contraction. Propranolol had no effect on rat uterus; but its presence in the bathing medium increased activity of adrenaline. 5-Hydroxytryptamine (5-HT) had no effect of its own on isolated rat uterus but its presence in the bathing medium enhanced contractions of carbachol and oxytocin.
Venkatakrishna-Bhatt
H
H
Department of Neurobehavioural Toxicology, National Institute of Occupational Health (ICMR), Meghani Nagar, Ahmedabad, India.
Panchal
G M
GM
D000818:Animals; D005260:Female; D005557:Formaldehyde / Q000633:toxicity*; D066298:In Vitro Techniques; D051381:Rats; D011919:Rats, Inbred Strains; D011941:Receptors, Adrenergic / Q000187:drug effects; D011950:Receptors, Cholinergic / Q000187:drug effects; D011985:Receptors, Serotonin / Q000187:drug effects; D014590:Uterine Contraction / Q000187:drug effects; D014599:Uterus / Q000187:drug effects*
D011941:Receptors, Adrenergic; D011950:Receptors, Cholinergic; D011985:Receptors, Serotonin; D005557:Formaldehyde