title: Isolation and identification of a cytotoxic principle from Chrysosplenium grayanum Maxim. (Saxifragaceae) and its antitumor activities.
abstract: A cytotoxic principle was newly isolated from Chrysosplenium grayanum Maxim. (Saxifragaceae) and identified as beta-peltoboykinolic acid (1) on the basis of spectral data. Cytotoxicity of compound 1 was tested against various human cancer cell lines in vitro, and antitumor effect of this compound was demonstrated on Meth.A mouse fibrosarcoma. The experiment of combined treatment with compound 1, mitomycin C, and OK-432 resulted in enhancing the antitumor effect against B16-BL6 mouse melanoma in C57BL/6 mice.
authors.affiliation: Department of Medicinal Resources, Faculty of Pharmaceutical Sciences, Toyama Medical & Pharmaceutical University, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Arisawa
authors.forename: H
authors.initials: H
authors.lastname: Bai
authors.forename: S
authors.initials: S
authors.lastname: Shimizu
authors.forename: S
authors.initials: S
authors.lastname: Koshimura
authors.forename: M
authors.initials: M
authors.lastname: Tanaka
authors.forename: T
authors.initials: T
authors.lastname: Sasaki
authors.forename: N
authors.initials: N
authors.lastname: Morita
mesh_terms: D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000302:isolation & purification* / Q000633:toxicity; D002460:Cell Line; D003603:Cytotoxins / Q000302:isolation & purification* / Q000633:toxicity; D005419:Flavonoids / Q000302:isolation & purification* / Q000633:toxicity; D006131:Growth Inhibitors / Q000302:isolation & purification / Q000633:toxicity; D006801:Humans; D051379:Mice; D008807:Mice, Inbred BALB C; D008810:Mice, Inbred C57BL; D010946:Plants, Medicinal / Q000737:chemistry*; D014407:Tumor Cells, Cultured
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D003603:Cytotoxins; D005419:Flavonoids; D006131:Growth Inhibitors