[Plasma glycosylated residues demonstrated by proton NMR spectroscopy. Value in the detection of heart graft rejection].
In conjunction with biopsy and Doppler studies, we analysed by high resolution proton NMR spectroscopy the blood plasma of 22 heart transplant recipients. There was a significant variation in the glycosylated residues of proteins with the development of acute cardiac rejection. A more extensive study is underway to assess the sensitivity and specificity of this approach for the early diagnosis of acute cardiac rejection.
Mouly-Bandini
A
A
Service de Chirurgie Cardiaque, CHU de la Timone, Marseille.
Vion-Dury
J
J
Sciaky
M
M
Viout
P
P
Confort-Gouny
S
S
Mesana
T
T
Goudard
A
A
Monties
J R
JR
Cozzone
P J
PJ
D000117:Acetylglucosamine / Q000097:blood*; D006084:Graft Rejection / Q000097:blood / Q000175:diagnosis* / Q000209:etiology; D016027:Heart Transplantation / Q000009:adverse effects*; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D012794:Sialic Acids / Q000097:blood*
D012794:Sialic Acids; D000117:Acetylglucosamine
Résidus glycosylés plasmatiques mis en évidence par spectroscopie de RMN du proton. Intérêt dans la détection du rejet de greffe cardiaque.