title: [Chronic use of glucomannan in the dietary treatment of severe obesity].
abstract: Two groups of 25 severely obese patients underwent 3 months of hypocaloric diet therapy either alone or associated with a glucomannan-based fibrous diet supplement (approx. 4 g/die in 3 doses). The comparative analysis of the results obtained in both groups showed that the diet + glucomannan group had a more significant weight loss in relation to the fatty mass alone, an overall improvement in lipid status and carbohydrate tolerance, and a greater adherence to the diet in the absence of any relevant side effects. Due to the marked ability to satiate patients and the positive metabolic effects, glucomannan diet supplements have been found to be particularly efficacious and well tolerated even in the long-term treatment of severe obesity.
authors.affiliation: Centro per la Farmacoterapia delle Malattie Nutrizionali, Università degli Studi di Milano.
authors.forename: P M
authors.initials: PM
authors.lastname: Vita
authors.forename: A
authors.initials: A
authors.lastname: Restelli
authors.forename: P
authors.initials: P
authors.lastname: Caspani
authors.forename: R
authors.initials: R
authors.lastname: Klinger
mesh_terms: D000328:Adult; D001786:Blood Glucose / Q000032:analysis; D002400:Cathartics / Q000008:administration & dosage / Q000627:therapeutic use*; D002784:Cholesterol / Q000097:blood; D004043:Dietary Fiber / Q000008:administration & dosage / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D008297:Male; D008351:Mannans / Q000008:administration & dosage / Q000627:therapeutic use*; D008875:Middle Aged; D009765:Obesity / Q000097:blood / Q000178:diet therapy* / Q000188:drug therapy; D012527:Satiation; D013997:Time Factors; D014280:Triglycerides / Q000097:blood; D015431:Weight Loss
chemical_list: D001786:Blood Glucose; D002400:Cathartics; D004043:Dietary Fiber; D008351:Mannans; D014280:Triglycerides; C022901:(1-6)-alpha-glucomannan; D002784:Cholesterol
vernacular_title: Impiego cronico del glucomannano nel trattamento dietetico delle obesità severe.