The effect of thymic hormones (TFX) on lymphocyte subpopulations and proliferation after maximal physical effort.
The studies were performed on healthy well-trained cyclists. Maximal physical exercise was performed on a Monark bicycle ergometer according to individual schemes. Heart rate amounting to about 200 bts/min and oxygen consumption stabilization were considered as criteria for maximal physical exercise. In this study we have investigated the effect of short-term stimulation of conditioned sportsmen with thymic hormones and evaluated T cell subsets, DR antigen and transferrin receptor expression as well as mitogen-induced proliferation of lymphocytes before and after maximal physical effort. The results suggest that intensive physical exercise may be responsible for transient decrease of CD4/CD8 ratio and mitogen responsiveness, and increase of mononuclear cells number bearing HLA DR+ and CD71 antigens. These changes were modified by the treatment with thymic hormones.
Tchórzewski
H
H
Department of Pathophysiology and Immunology, Institute of Basic Medical Sciences, Lódz, Poland.
Zeman
K
K
Lewicki
R
R
Pokoca
L
L
Fornalczyk-Wachowska
E
E
Kantorski
J
J
Majewska
E
E
Golińska
A
A
D000328:Adult; D015703:Antigens, CD / Q000032:analysis; D005080:Exercise Test; D006684:HLA-DR Antigens / Q000032:analysis; D006801:Humans; D016130:Immunophenotyping; D008213:Lymphocyte Activation / Q000187:drug effects / Q000502:physiology*; D007959:Lymphocyte Culture Test, Mixed; D016131:Lymphocyte Subsets / Q000187:drug effects / Q000276:immunology*; D008297:Male; D005082:Physical Exertion; D013951:Thymus Hormones / Q000494:pharmacology / Q000502:physiology*
D015703:Antigens, CD; D006684:HLA-DR Antigens; D013951:Thymus Hormones