title: Chronic Pseudomonas aeruginosa endobronchitis in rhesus monkeys: I. Effects of pentoxifylline on neutrophil influx.
abstract: Host defense abnormalities in cystic fibrosis (CF) against Pseudomonas aeruginosa (PA) lead to excessive neutrophil influx into the infected lungs, resulting in pulmonary complications. We have developed a rhesus monkey model of chronic PA endobronchitis by intrabronchial instillation of PA-embedded agar beads, utilizing flexible fiberoptic bronchoscopy. Treatment of infected monkeys with pentoxifylline suppressed neutrophil influx and ameliorated pulmonary damage. The results suggest a method by which neutrophil influx and pulmonary damage in CF patients can be managed or prevented.
authors.affiliation: Department of Medical Pathology, University of California, Davis.
authors.forename: A T
authors.initials: AT
authors.lastname: Cheung
authors.forename: R B
authors.initials: RB
authors.lastname: Moss
authors.forename: A B
authors.initials: AB
authors.lastname: Leong
authors.forename: W J
authors.initials: WJ
authors.lastname: Novick
mesh_terms: D000818:Animals; D001991:Bronchitis / Q000150:complications / Q000188:drug therapy* / Q000473:pathology; D001992:Bronchoalveolar Lavage Fluid / Q000473:pathology; D002908:Chronic Disease; D003550:Cystic Fibrosis / Q000150:complications; D004195:Disease Models, Animal; D008168:Lung / Q000473:pathology; D008253:Macaca mulatta; D009504:Neutrophils / Q000187:drug effects / Q000473:pathology; D010431:Pentoxifylline / Q000627:therapeutic use*; D011552:Pseudomonas Infections / Q000150:complications / Q000188:drug therapy* / Q000473:pathology
chemical_list: D010431:Pentoxifylline