Effect of sodium butyrate on glucocorticoid-sensitive and -resistant P1798 lymphosarcoma.
This study aims to examine the effect of sodium butyrate on the viability and the level of glucocorticoid receptors and cells cycle progression in glucocorticoid-sensitive and -resistant P1798 cells. Our results indicated that low levels of sodium butyrate had no effect on either the viability or the receptor level. However, high-level (5 mM) sodium butyrate appeared to reduce cell viability as well as the glucocorticoid receptor level. On the other hand, sodium butyrate inhibited cell cycle progression in a dose-dependent manner. This response was similar in both the glucocorticoid-sensitive and -resistant P1798 cells. Results from this study suggested that the sodium butyrate induced effect may be cell cycle related.
Chang
Y F
YF
Department of Medical Research, Veterans General Hospital-Taipei, Taiwan, R.O.C.
Wu
L H
LH
Liu
T Y
TY
Yang
J C
JC
Chi
C W
CW
D002087:Butyrates / Q000494:pharmacology*; D020148:Butyric Acid; D002453:Cell Cycle / Q000187:drug effects; D002470:Cell Survival / Q000187:drug effects; D004351:Drug Resistance; D005938:Glucocorticoids / Q000494:pharmacology*; D006801:Humans; D008228:Lymphoma, Non-Hodgkin / Q000378:metabolism / Q000473:pathology*; D011965:Receptors, Glucocorticoid / Q000378:metabolism; D014407:Tumor Cells, Cultured / Q000187:drug effects / Q000378:metabolism
D002087:Butyrates; D005938:Glucocorticoids; D011965:Receptors, Glucocorticoid; D020148:Butyric Acid