title: In vitro and in vivo effects of PGE2 on cementless fixation of implant.
abstract: The effects of prostaglandin E2(PGE2) in vivo and in vitro on cementless fixation of porous coated implant were studied. The results revealed that high levels of PGE2 in the local tissue benefit bone ingrowth in the early stage of implantation. Co-Cr-Mo alloy itself hampers the growth of osteoblasts and decreases the local secretion of PGE2. In the early stage of arthroplasty, the use of PGE2 inhibitors should be forbidden, and proper loading stimulation is preferable. High level PGE2 of local tissue in the later stage indicates bone resorption.
authors.affiliation: Department of Orthopaedics, PLA General Hospital, Beijing.
authors.forename: Y Q
authors.initials: YQ
authors.lastname: Sun
authors.forename: S B
authors.initials: SB
authors.lastname: Lu
authors.forename: J F
authors.initials: JF
authors.lastname: Wang
mesh_terms: D000497:Alloys; D000818:Animals; D001842:Bone and Bones / Q000166:cytology / Q000601:surgery; D002478:Cells, Cultured; D002858:Chromium Alloys; D015232:Dinoprostone / Q000378:metabolism / Q000494:pharmacology*; D005121:Extremities / Q000601:surgery; D005269:Femur / Q000293:injuries; D017102:Fracture Healing; D008982:Molybdenum; D010006:Osteoblasts / Q000166:cytology; D019736:Prostheses and Implants; D011817:Rabbits
chemical_list: D000497:Alloys; D002858:Chromium Alloys; D008982:Molybdenum; D015232:Dinoprostone