title: Relapsing and remitting human immunodeficiency virus-associated leukoencephalomyelopathy.
abstract: We describe a 33-year-old homosexual man with a steroid-responsive, remitting and relapsing leukoencephalopathy associated with recent human immunodeficiency virus type 1 (HIV-1) seroconversion. Biopsy of a parieto-occipital lesion revealed demyelination and astrogliosis with focal necrosis. Detailed investigations demonstrated no pathogens in the brain other than HIV-1. This patient illustrates that a neurological disorder clinically indistinguishable from multiple sclerosis may be the presenting manifestation of HIV-1 infection and may occur in the absence of clinically significant immunosuppression.
authors.affiliation: Department of Neurology, University of Miami School of Medicine, FL 33151.
authors.forename: J R
authors.initials: JR
authors.lastname: Berger
authors.forename: C
authors.initials: C
authors.lastname: Tornatore
authors.forename: E O
authors.initials: EO
authors.lastname: Major
authors.forename: J
authors.initials: J
authors.lastname: Bruce
authors.forename: P
authors.initials: P
authors.lastname: Shapshak
authors.forename: M
authors.initials: M
authors.lastname: Yoshioka
authors.forename: S
authors.initials: S
authors.lastname: Houff
authors.forename: W
authors.initials: W
authors.lastname: Sheremata
authors.forename: G F
authors.initials: GF
authors.lastname: Horton
authors.forename: H
authors.initials: H
authors.lastname: Landy
mesh_terms: D015526:AIDS Dementia Complex / Q000175:diagnosis; D000328:Adult; D001853:Bone Marrow / Q000382:microbiology; D001921:Brain / Q000382:microbiology / Q000473:pathology; D003711:Demyelinating Diseases / Q000175:diagnosis / Q000382:microbiology* / Q000473:pathology; D003937:Diagnosis, Differential; D015658:HIV Infections / Q000150:complications*; D015497:HIV-1 / Q000302:isolation & purification / Q000472:pathogenicity*; D006801:Humans; D007577:JC Virus / Q000302:isolation & purification; D007968:Leukoencephalopathy, Progressive Multifocal / Q000175:diagnosis; D008297:Male; D009103:Multiple Sclerosis / Q000175:diagnosis; D012008:Recurrence