[Immunodeficiency caused by graft versus host reaction. Extra-thymic effect of thymus in restoring immunity].
Cell-mediated immunity in lethally irradiated graft-versus-host mice can be restored after repopulation with syngeneic bone marrow cells and thymus grafting. The thymus is not only required for the maturation of T lymphocytes, but also for the inhibition of a radioresistant mechanism resulting in lymphoid cell rejection.
Lang
P
P
INSERM U 139, Hôpital Henri-Mondor, Créteil.
Bierre
V
V
Baron
C
C
Rostoker
G
G
Weil
B
B
D000818:Animals; D016026:Bone Marrow Transplantation / Q000379:methods*; D006087:Graft vs Host Reaction / Q000502:physiology*; D007108:Immune Tolerance / Q000502:physiology*; D007153:Immunologic Deficiency Syndromes / Q000209:etiology; D051379:Mice; D013950:Thymus Gland / Q000637:transplantation*
Déficit immunitaire lié à la réaction du greffon contre l'hôte. Influence extra-thymique du thymus dans la restauration de l'immunité.