[Investigation of immunogenic properties of diphtheria antitoxin by intradermal active test of potency].
Usefulness of four variants of intradermal test for routine testing of protective potency and diphtheria anatoxin was studied. Comparing with classical active test it was found that full intradermal test possesses data system and results comparable to the classic test and may replace it. This in effect results in four-fold reduction of guinea pig number necessary for performance of the investigation. As orientating test, estimate determining AnaDi potency a single dose performed on six guinea pigs was selected. In the intradermal test the time of investigation, as compared with the classic test, may be shortened by one week.
Wysokińska
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Zakład Badania Surowic i Szczepionek PZH w Warszawie.
Zakrzewska
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D000818:Animals; D004166:Diphtheria Antitoxin / Q000276:immunology*; D006168:Guinea Pigs; D012882:Skin Tests
D004166:Diphtheria Antitoxin
Badanie właściwości uodparniajacych anatoksyny błoniczej w śródskórnym teście czynnym mocy.