[Protective effect of proton pump inhibitor on the gastric mucosa].
Although many authors reported that proton pump inhibitor showed mucosal protective activity, the precise mechanism is still unclear. In this study, we investigated the effect of proton pump inhibit on gastric mucosal hemodynamics, using a reflectance spectrophotometry system. The proton pump inhibitors had no effect on the gastric mucosal hemodynamics prior to the state of hemorrhagic shock state. However, during the hemorrhagic shock, proton pump inhibitors significantly inhibited the decrease in tissue oxygenation and significantly reduced ulcer formation. In conclusion, proton pump inhibitors maintained tissue oxygenation resulting in reduction of ulcer formation.
Kawano
S
S
Department of Medicine, Osaka University Medical School.
Tsuji
S
S
Masuda
E
E
Hayashi
N
N
Tsujii
M
M
Michida
T
T
Kobayashi
I
I
Fusamoto
H
H
Kamada
T
T
D000251:Adenosine Triphosphatases / Q000037:antagonists & inhibitors*; D000818:Animals; D000897:Anti-Ulcer Agents; D005753:Gastric Mucosa / Q000098:blood supply* / Q000378:metabolism; D017506:H(+)-K(+)-Exchanging ATPase; D006439:Hemodynamics / Q000187:drug effects; D008297:Male; D009853:Omeprazole / Q000494:pharmacology*; D010101:Oxygen Consumption / Q000187:drug effects; D051381:Rats; D011919:Rats, Inbred Strains
D000897:Anti-Ulcer Agents; D000251:Adenosine Triphosphatases; D017506:H(+)-K(+)-Exchanging ATPase; D009853:Omeprazole