Phenobarbital-responsive episodic dyscontrol (rage) in dogs.
Episodic dyscontrol (rage) was diagnosed from the clinical history, electroencephalographic findings, and response to oral treatment with phenobarbital in 3 dogs. Clinical features included a mood change heralding aggressive incidents, explosive aggression directed at people or objects, and a postaggressive phase characterized by lethargy and lack of responsiveness. Abnormal electroencephalographic findings included spike activity in the temporal recordings. All 3 dogs responded well to anticonvulsant medication with phenobarbital.
Dodman
N H
NH
Department of Surgery, Tufts University School of Veterinary Medicine, North Grafton, MA 01536.
Miczek
K A
KA
Knowles
K
K
Thalhammer
J G
JG
Shuster
L
L
D000374:Aggression / Q000187:drug effects*; D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects*; D004283:Dog Diseases / Q000188:drug therapy*; D004285:Dogs; D004569:Electroencephalography / Q000662:veterinary; D004833:Epilepsy, Temporal Lobe / Q000188:drug therapy / Q000662:veterinary*; D005500:Follow-Up Studies; D008297:Male; D010634:Phenobarbital / Q000494:pharmacology / Q000627:therapeutic use*; D013577:Syndrome
D010634:Phenobarbital