title: Tissue-specific production of the third component of complement(C3) by vitamin D in bone.
abstract: The third component of complement (C3) is a protein produced by osteoblastic cells in response to 1 alpha,25(OH)2D3. The bone C3 appears to be involved in differentiation of bone marrow cells into osteoclasts in concert with other vitamin D-dependent factors. Further studies are needed to understand the precise role of C3 in bone.
authors.affiliation: Department of Biochemistry, School of Dentistry, Showa University, Tokyo, Japan.
authors.forename: E
authors.initials: E
authors.lastname: Abe
authors.forename: C H
authors.initials: CH
authors.lastname: Jin
authors.forename: M H
authors.initials: MH
authors.lastname: Hong
authors.forename: T
authors.initials: T
authors.lastname: Sato
authors.forename: T
authors.initials: T
authors.lastname: Shinki
authors.forename: T
authors.initials: T
authors.lastname: Suda
mesh_terms: D000818:Animals; D001842:Bone and Bones / Q000166:cytology / Q000187:drug effects* / Q000378:metabolism; D002117:Calcitriol / Q000494:pharmacology*; D003176:Complement C3 / Q000096:biosynthesis* / Q000502:physiology; D008099:Liver / Q000166:cytology / Q000187:drug effects / Q000378:metabolism; D008970:Molecular Weight; D010006:Osteoblasts / Q000187:drug effects / Q000378:metabolism; D011506:Proteins / Q000032:analysis; D012680:Sensitivity and Specificity
chemical_list: D003176:Complement C3; D011506:Proteins; D002117:Calcitriol