title: Selective inhibition of in vitro cell growth by the anti-tumour drug Ukrain.
abstract: The inhibitory effect of Ukrain on malignant cells and on normal cells, in vitro, has been compared. To obtain a 50% inhibition of cell growth, a tenfold concentration had to be used with normal endothelial cells compared to a human osteosarcoma cell line. Hybrids of the two cell types showed nearly the same sensitivity as normal cells. A laser scanning microscope showed a high uptake of Ukrain in malignant cells, while the content in normal cells under the same experimental conditions was substantially lower.
authors.affiliation: Institute of Applied Microbiology, University of Agriculture, Vienna, Austria.
authors.forename: O
authors.initials: O
authors.lastname: Hohenwarter
authors.forename: K
authors.initials: K
authors.lastname: Strutzenberger
authors.forename: H
authors.initials: H
authors.lastname: Katinger
authors.forename: A
authors.initials: A
authors.lastname: Liepins
authors.forename: J W
authors.initials: JW
authors.lastname: Nowicky
mesh_terms: D000470:Alkaloids / Q000494:pharmacology*; D000972:Antineoplastic Agents, Phytogenic / Q000494:pharmacology*; D001600:Berberine Alkaloids; D002455:Cell Division / Q000187:drug effects; D004730:Endothelium, Vascular / Q000166:cytology; D006801:Humans; D006822:Hybrid Cells / Q000187:drug effects; D008545:Melanoma / Q000473:pathology; D008856:Microscopy, Fluorescence; D012516:Osteosarcoma / Q000473:pathology; D010617:Phenanthridines; D014407:Tumor Cells, Cultured / Q000187:drug effects
chemical_list: D000470:Alkaloids; D000972:Antineoplastic Agents, Phytogenic; D001600:Berberine Alkaloids; D010617:Phenanthridines; C060921:ukrain