[Randomized comparative study using carbocalcitonin i.m. vs carbocalcitonin nasal spray vs ipriflavone x os in the treatment of post-menopausal osteoporosis].
A comparative study of 90 post-menopausal osteoporotic women, has been carried out. The patients were divided in 3 homogeneous groups. According to 3 different schemes: Group A = 30 patients received carbocalcitonin i.m. 40 UMRC/day/1 month and 40 UMRC/alternating days/2 months followed by 1 month of wash-out for 11 months; Group B = 30 patients received carbolcitonin nasal-spray 80 UMRC/day/1 month and 80 UMRC/alternating day/2 months followed by 1 month of wash-out for 11 months; Group C = 30 patients received ipriflavone x os (600 mg/day/3 months followed by 1 month of wash-out for 3 times). BMC significantly was increased in all Groups after 7 and 11 months. In conclusion, carbocalcitonin and ipriflavone seem to show a similar improving densitometric effect in post-menopausal osteoporosis.
Lobianco
R
R
Dipartimento di Patologia Sistematica, II Facoltà di Medicina e Chirurgia, Università degli Studi Federico II, Napoli.
Merola
B
B
Lupoli
G
G
Cocca
A
A
Guarino
M
M
Pia
M
M
Guerriero
S
S
Lombardi
G
G
D000281:Administration, Intranasal; D000284:Administration, Oral; D000368:Aged; D002116:Calcitonin / Q000031:analogs & derivatives* / Q000627:therapeutic use; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007273:Injections, Intramuscular; D007529:Isoflavones / Q000627:therapeutic use*; D008875:Middle Aged; D015663:Osteoporosis, Postmenopausal / Q000188:drug therapy* / Q000378:metabolism
D007529:Isoflavones; C018986:ipriflavone; D002116:Calcitonin; C012755:elcatonin
Studio comparativo randomizzato con carbocalcitonina i.m. vs carbocalcitonina spray nasale vs ipriflavone x os nel trattamento dell'osteoporosi post-menopausale.