[Bipolar disorder: clinical trials with fluoxetine].
Sixty patients (39 females and 21 males) aged between 20 and 65 (average 48.5) with bipolar disorder in the depressive phase, according to the DSM III-R diagnostic criteria, were treated with fluoxetine (20-60 mg/die) for 8 weeks. Evaluation of therapeutical efficacy was performed at 0 time and after 14, 28, 42, and 56 days, using the following psychometric tests; HAM-D, SCL-90, CGI. At the end of treatment 42 patients (70%) showed a reduction of the HAM-D score over 50%. Clinical results suggest that fluoxetine is affective in bipolar disorder. Tolerability was judged good and very good in 76% of patients. Side effects were very mild and in any case of rapid regression.
Ambrosio
L A
LA
Servizio di Psichiatria, Ospedale Civile Dell'Annunziata, Cosenza.
Buccomino
D
D
Filippo
A
A
Filippo
P
P
Marchese
G
G
Barrese
E
E
Paoletti
C
C
Colonna
C V
CV
D000328:Adult; D000368:Aged; D003866:Depressive Disorder / Q000175:diagnosis / Q000188:drug therapy*; D005260:Female; D005473:Fluoxetine / Q000008:administration & dosage / Q000627:therapeutic use*; D006801:Humans; D007398:Interpersonal Relations; D008297:Male; D008875:Middle Aged; D011569:Psychiatric Status Rating Scales; D011594:Psychometrics; D016896:Treatment Outcome
D005473:Fluoxetine
Disturbo bipolare: esperienze cliniche con fluoxetina.