[Clinical observation on efficacy of ivermectin in the treatment of intestinal nematode infections].
A total of 166 cases were divided into 3 groups: group A comprised 55, group B 54 and group C 57 cases. Group A received ivermectin 0.1 mg/kg orally at a single dose, the cure rates were 100%, 3.8% and 50% for ascaris, hookworm and trichuris, infections respectively: group B received ivermectin 0.2 mg/kg orally at a single dose, the corresponding cure rates were 95.5%, 11.8% and 76.5% respectively; group C received pyrantel pamoate 10 mg/kg orally at a single dose, the corresponding cure rates were 95.5%, 29.6% and 31.6% respectively. Although the cure rates were very low for hookworm infection in both group A and B, however, a number of adult worms of Ancylostoma duodenale and Necator americanus were expelled aster medication; It indicates that ivermectin has some effects on these two species of human hookworm. Side effects were mild and transient in all groups.
Xia
Z H
ZH
Institute of Parasitic Diseases, Zhejiang Academy of Medical Sciences, Hangzhou.
Su
Y L
YL
Yao
S Y
SY
Shen
B R
BR
Wen
L Y
LY
Song
C C
CC
Wu
Z K
ZK
Zou
Y C
YC
Meng
J C
JC
Yang
H L
HL
D000293:Adolescent; D000328:Adult; D000722:Ancylostoma / Q000187:drug effects; D000818:Animals; D001196:Ascariasis / Q000188:drug therapy; D006725:Hookworm Infections / Q000188:drug therapy; D006801:Humans; D007411:Intestinal Diseases, Parasitic / Q000188:drug therapy*; D007559:Ivermectin / Q000627:therapeutic use*; D017221:Necator americanus / Q000187:drug effects; D009349:Nematode Infections / Q000188:drug therapy*; D011716:Pyrantel Pamoate / Q000627:therapeutic use; D014257:Trichuriasis / Q000188:drug therapy
D007559:Ivermectin; D011716:Pyrantel Pamoate