[Effect of protectors on morphofunctional changes in rat kidneys in tourniquet shock].
The protective effect produced on the kidneys in tourniquet shock by thiol agents possessing antioxidant properties (unithiol, cystamine) was compared with that of a preparation of cell capsules of L. bulgaricus (CCLB). Tourniquet shock was modeled under ether Raush anesthesia by applying 8 turns of a rubber tourniquet to the hind limbs for 6 hours. Thirty minutes before removal of the tourniquet animals of the first group were given an injection of 1 ml of physiological solution, animals of the second group--20 mg/kg of unithol, those of the third group received an injection of 20 mg/kg of cystamine hydrochloride. Animals of the fourth group received 50 mg/kg of CCLB in 1 ml of physiological solution 7 days before the experiment. A marked protective effect of CCLB on the kidneys in tourniquet shock was established. According to the degree of the protective effect on the tissue of kidneys in tourniquet shock, the studied agents come in the following order: CCLB, cystamine, unithiol.
Shleĭkin
A G
AG
Shulutko
B I
BI
Oksman
T M
TM
Orlov
A V
AV
D000818:Animals; D016667:Bacterial Capsules / Q000494:pharmacology*; D003538:Cystamine / Q000494:pharmacology*; D007668:Kidney / Q000187:drug effects* / Q000473:pathology; D008297:Male; D051381:Rats; D012769:Shock / Q000188:drug therapy*; D014111:Tourniquets / Q000009:adverse effects*; D014494:Unithiol / Q000494:pharmacology*
D014494:Unithiol; D003538:Cystamine
Vliianie protektorov na morfofunktsional'nye izmeneniia pochek u krys pri turniketnom shoke.