title: Cutaneous angiocentric T-cell lymphoma associated with Epstein-Barr virus.
abstract: BACKGROUND
  Two unusual cases of cutaneous angiocentric T-cell lymphoma were found to be associated with Epstein-Barr virus infection.
  
  
  OBJECTIVE
  The objective was to study the clinical course and the response of the disease to conventional chemotherapy.
  
  
  METHODS
  Histologic specimens from both patients were studied. Clonal proliferation was assessed by Southern blot hybridization.
  
  
  RESULTS
  The disease in both patients was rapidly progressive and responded poorly to aggressive treatment. Biopsy specimens showed infiltration of atypical lymphoid cells with angiocentricity and angiodestruction, which probably resulted in the observed tissue necrosis. Clonal proliferation of Epstein-Barr virus DNA was detected in tissue from primary skin lesions and disseminated nasal lesions.
  
  
  CONCLUSIONS
  Epstein-Barr virus-associated angiocentric T-cell lymphoma in our patients was characterized by an aggressive course and resistance to conventional chemotherapy. A search for Epstein-Barr virus and the human T-lymphotropic virus should be performed in patients with atypical features of cutaneous T-cell lymphoma.
authors.affiliation: Department of Dermatology, National Taiwan University Hospital, Taipei, Republic of China.
authors.forename: T F
authors.initials: TF
authors.lastname: Tsai
authors.forename: I J
authors.initials: IJ
authors.lastname: Su
authors.forename: Y C
authors.initials: YC
authors.lastname: Lu
authors.forename: A L
authors.initials: AL
authors.lastname: Cheng
authors.forename: H P
authors.initials: HP
authors.lastname: Yeh
authors.forename: H C
authors.initials: HC
authors.lastname: Hsieh
authors.forename: H F
authors.initials: HF
authors.lastname: Tien
authors.forename: J S
authors.initials: JS
authors.lastname: Chen
authors.forename: W C
authors.initials: WC
authors.lastname: Uen
mesh_terms: D000328:Adult; D000368:Aged; D000914:Antibodies, Viral / Q000032:analysis; D015139:Blotting, Southern; D005260:Female; D004854:Herpesvirus 4, Human / Q000235:genetics / Q000276:immunology / Q000302:isolation & purification*; D006801:Humans; D016130:Immunophenotyping; D007621:Karyotyping; D016410:Lymphoma, T-Cell, Cutaneous / Q000235:genetics / Q000276:immunology / Q000382:microbiology* / Q000473:pathology; D008297:Male; D010412:Penile Neoplasms / Q000235:genetics / Q000276:immunology / Q000382:microbiology / Q000473:pathology; D012867:Skin / Q000473:pathology; D012878:Skin Neoplasms / Q000235:genetics / Q000276:immunology / Q000382:microbiology* / Q000473:pathology
chemical_list: D000914:Antibodies, Viral