title: [Adaptation to periodic hypoxia decreases ethanol consumption and abstinence-related damages to the internal organs during withdrawal in chronically alcoholized animals].
abstract: Adaptation to intermittent hypoxia in a hypobaric altitude chamber reduced two-fold ethanol consumption in chronically alcoholized rats and limited or eliminated abstinence syndrome. The effect of the adaptation was evident from prevented development of abstinence analgesia, enhanced alcohol consumption following deprivation, abstinence activation of lipid peroxidation in the liver, and release of hepato-specific enzymes fructose monophosphate and gamma-glutamyl transpeptidase into blood. At the same time adaptation prevented the fall of cardiac fibrillation threshold and pronounced disturbance of ventricular contraction and relaxation. The problem is discussed of using adaptation to intermittent hypoxia in the treatment for those forms of alcoholism in which abstinence plays the key role.
authors.forename: F Z
authors.initials: FZ
authors.lastname: Meerson
authors.forename: S I
authors.initials: SI
authors.lastname: Krasikov
authors.forename: I I
authors.initials: II
authors.lastname: Chavkin
authors.forename: M S
authors.initials: MS
authors.lastname: Bikbulatov
authors.forename: V P
authors.initials: VP
authors.lastname: Tverdokhlib
mesh_terms: D000222:Adaptation, Physiological / Q000502:physiology*; D000428:Alcohol Drinking / Q000503:physiopathology*; D000437:Alcoholism / Q000503:physiopathology*; D000818:Animals; D001273:Atmosphere Exposure Chambers; D000431:Ethanol / Q000009:adverse effects*; D006321:Heart / Q000187:drug effects / Q000503:physiopathology; D000860:Hypoxia / Q000503:physiopathology*; D008099:Liver / Q000187:drug effects / Q000503:physiopathology; D008297:Male; D010507:Periodicity; D051381:Rats; D017208:Rats, Wistar; D013375:Substance Withdrawal Syndrome / Q000503:physiopathology*; D013997:Time Factors
chemical_list: D000431:Ethanol
vernacular_title: Adaptatsiia k periodicheskoĭ gipoksii umen'shaet potreblenie étanola i abstinentnye povrezhdeniia vnutrennikh organov pri ego otmene u khronicheski alkogolizirovannykh zhivotnykh.