[The effect of synthetic enkephalins on prostaglandin synthesis and lipid peroxidation in the isolated heart during the activation of free-radical processes].
The system Fe(2+)-ascorbate was used for lipid peroxidation (LPO) activation in isolated heart tissue. The stimulation of free radical processes in the myocardium caused a rise in the level of LPO products and a significant lowering of that of prostacyclin. Intravenous injection of synthetic analogues of enkephalins before LPO activation inhibited LPO and resulted in prostacyclin synthesis normalization. The addition of peptides under study into perfusion solution led to a decrease in LPO primary products level and in thromboxane synthesis.
Lishmanov
Iu B
IuB
Rebrova
T Iu
TIu
Afanas'ev
S A
SA
Kravchenko
A I
AI
D000818:Animals; D016308:Enkephalin, Leucine-2-Alanine / Q000031:analogs & derivatives / Q000494:pharmacology; D004744:Enkephalin, Methionine / Q000031:analogs & derivatives / Q000494:pharmacology; D004745:Enkephalins / Q000494:pharmacology*; D005260:Female; D005609:Free Radicals / Q000378:metabolism; D006321:Heart / Q000187:drug effects*; D066298:In Vitro Techniques; D015227:Lipid Peroxidation / Q000187:drug effects*; D009206:Myocardium / Q000378:metabolism*; D011453:Prostaglandins / Q000096:biosynthesis*; D051381:Rats; D013931:Thromboxanes / Q000096:biosynthesis
D004745:Enkephalins; D005609:Free Radicals; D011453:Prostaglandins; D013931:Thromboxanes; D004744:Enkephalin, Methionine; C021717:enkephalin, Met(2)-ProNH2(5)-; D016308:Enkephalin, Leucine-2-Alanine; C040996:enkephalin-Leu, Ala(2)-Arg(6)-
Vliianie sinteticheskikh énkefalinov na sintez prostaglandinov i perekisnoe okislenie lipidov v izolirovannom serdtse pri aktivatsii svobodnoradikal'nykh protsessov.