[Effects of benzene on lipid peroxidation and the activity of relevant enzymes in human].
Lipid peroxidation and the activity of relevant enzymes in workers exposed to benzene were measured. The results indicated that the content of serum malondialdehyde (MDA) increased while the activity of erythrocyte superoxide dismutase (SOD) and erythrocyte glutathione peroxidase (GSH-Px) decreased. The above changes were statistically significant as compared with the control group when the concentration of air benzene in the working environment was 50.21 mg/m3 and became more obvious with the increase of the concentration of air benzene. These changes occurred earlier, and more sensitively reflected the effect of benzene on human beings than changes of leukocyte and platelet counts.
Chen
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Department of Labour Hygiene and Occupational Diseases, Guangdong Medical and Pharmaceutical College, Guangzhou.
D000395:Air Pollutants, Occupational / Q000009:adverse effects* / Q000032:analysis; D001554:Benzene / Q000009:adverse effects* / Q000032:analysis; D005260:Female; D005979:Glutathione Peroxidase / Q000097:blood; D006801:Humans; D015227:Lipid Peroxidation / Q000187:drug effects*; D008315:Malondialdehyde / Q000097:blood*; D016273:Occupational Exposure; D013482:Superoxide Dismutase / Q000097:blood*
D000395:Air Pollutants, Occupational; D008315:Malondialdehyde; D005979:Glutathione Peroxidase; D013482:Superoxide Dismutase; D001554:Benzene