title: Effect of a fluoride solution on dentinal hypersensitivity.
abstract: This two-phase experiment assessed the effects over time of a solution containing 1.09% sodium fluoride, .40% stannous fluoride, and .14% hydrogen fluoride (.717% fluoride solution, DentinBloc) on pain associated with dentinal hypersensitivity. During phase I, 30 subjects demonstrating dentinal hypersensitivity to a blast of cool air were divided into three double blind experimental groups. After baseline data were collected for all subjects, one group was instructed to apply the .717% fluoride solution twice a day. A second group was instructed to apply a gel containing .04% stannous fluoride (Gel-Kam) twice a day. A third group was instructed to apply distilled water. Each subject was assessed at 2, 4, 8, and 16 weeks utilizing the "method of limits" with a standardized, repeatable cold thermal stimulus. The results of a two factor repeated ANOVA indicated that those subjects who applied the .717% fluoride solution reported significantly less sensitivity at the 2-week period than the other groups (P < .05). In addition, those subjects whose solution contained the 0.4% stannous fluoride reported significantly less sensitivity at the 4- to 8-week periods (P < .05). Phase II of the study assessed the .717% fluoride solution on a more precise time course. These included: immediately, 15 minute, 1 day, 1 week and 2 weeks. A one factor repeated ANOVA revealed that this effect presented 15-minute post application (P < .05) and continued throughout the testing periods. It was concluded that the fully active 0.717% fluoride solution was an effective agent in the control of dentinal hypersensitivity after two 1-minute applications.
authors.affiliation: Department of Community Dentistry, Dental School, University of Texas Health Science Center at San Antonio 78284-7917.
authors.forename: W J
authors.initials: WJ
authors.lastname: Thrash
authors.forename: D L
authors.initials: DL
authors.lastname: Jones
authors.forename: W J
authors.initials: WJ
authors.lastname: Dodds
mesh_terms: D000704:Analysis of Variance; D003807:Dentin Sensitivity / Q000188:drug therapy*; D004311:Double-Blind Method; D005460:Fluorides, Topical / Q000627:therapeutic use*; D006801:Humans; D006858:Hydrofluoric Acid / Q000627:therapeutic use; D008137:Longitudinal Studies; D010147:Pain Measurement; D017288:Pain Threshold; D012969:Sodium Fluoride / Q000627:therapeutic use; D013997:Time Factors; D014002:Tin Fluorides / Q000627:therapeutic use
chemical_list: D005460:Fluorides, Topical; D014002:Tin Fluorides; D012969:Sodium Fluoride; D006858:Hydrofluoric Acid