Anti-tumor-promoting activities of afromosin and soyasaponin I isolated from Wistaria brachybotrys.
Afromosin [1] and soyasaponin I [2] isolated from Wistaria brachybotrys exhibited remarkable inhibitory effects on mouse skin tumor promotion, and afromosin also exhibited a significant inhibitory effect on pulmonary tumor promotion. The combined effects of these compounds on the two-stage skin carcinogenesis were also examined, and it was concluded that the combination of 1 with 2 enhanced the inhibitory effect.
Konoshima
T
T
Kyoto Pharmaceutical University, Japan.
Kokumai
M
M
Kozuka
M
M
Tokuda
H
H
Nishino
H
H
Iwashima
A
A
D015127:9,10-Dimethyl-1,2-benzanthracene / Q000037:antagonists & inhibitors / Q000633:toxicity; D000818:Animals; D016588:Anticarcinogenic Agents / Q000302:isolation & purification* / Q000494:pharmacology; D003043:Cocarcinogenesis; D005260:Female; D007529:Isoflavones / Q000302:isolation & purification* / Q000494:pharmacology; D008175:Lung Neoplasms / Q000139:chemically induced / Q000517:prevention & control; D051379:Mice; D008813:Mice, Inbred ICR; D009828:Oleanolic Acid / Q000031:analogs & derivatives*; D010946:Plants, Medicinal / Q000737:chemistry*; D012503:Saponins / Q000302:isolation & purification* / Q000494:pharmacology; D012878:Skin Neoplasms / Q000139:chemically induced / Q000517:prevention & control; D013755:Tetradecanoylphorbol Acetate / Q000633:toxicity
D016588:Anticarcinogenic Agents; D007529:Isoflavones; D012503:Saponins; C056684:soyasaponin I; C080240:afromosin; D015127:9,10-Dimethyl-1,2-benzanthracene; D009828:Oleanolic Acid; D013755:Tetradecanoylphorbol Acetate