title: [Blood coagulation factors in hepatic disorders].
abstract: The major factors related to the coagulo-fibrinolytic reactions are synthesized in the hepatic cells. As a reticuloendothelial organ, the liver also removes the activated factors and metabolic products in the coagulo-fibrinolytic process from the plasma. Therefore, many investigators have been trying to use measurements of the coagulo-fibrinolytic factors for the evaluation of the type and degree of a hepatic disorder and for the determination of therapeutic effects or prognosis. On the other hand, the recent advances in the blood coagulation study show that the hemostatic mechanism is a kind of maintenance mechanism of homeostasis for blood-flow. The functions of many factors in and from the platelets and vascular endothelial cells as well as those produced by the liver have been identified. Recently, some hemostatic molecular markers and complexes of activated factors with their inhibitors can also be measured. In this article, the recent concept of hemostatic mechanism and the relation between various hemostatic factors and hepatic disorders are presented.
authors.affiliation: Japan Clinical Laboratories, Inc., Suita.
authors.forename: T
authors.initials: T
authors.lastname: Samori
mesh_terms: D001779:Blood Coagulation Factors / Q000032:analysis*; D006801:Humans; D008107:Liver Diseases / Q000097:blood*
chemical_list: D001779:Blood Coagulation Factors