[Antiarrhythmic effects of crebanine].
Crebanine (Cre) iv 5 mg/kg could convert BaCl2-induced arrhythmia into sinus rhythm in rats, and could significantly increase the tolerant dose of aconitine to produce ventricular fibrillation (VF) and cardiac arrest (CA) in rats. The drug could also decrease the incidence of VF and CA by CaCl2 in rats and by chloroform in mice, but had no protective effects on ouabain-induced arrhythmias in guinea pigs.
Yu
Z P
ZP
Department of Traditional Chinese Pharmacy, Yunnan College of TCM, Kunming.
Mu
Y S
YS
Zhao
Z X
ZX
Wang
F C
FC
D000157:Aconitine; D000818:Animals; D000889:Anti-Arrhythmia Agents / Q000627:therapeutic use*; D001060:Aporphines / Q000627:therapeutic use*; D001145:Arrhythmias, Cardiac / Q000139:chemically induced / Q000188:drug therapy*; D001464:Barium; D017609:Barium Compounds; D002712:Chlorides; D005260:Female; D006168:Guinea Pigs; D006323:Heart Arrest / Q000139:chemically induced / Q000517:prevention & control; D008297:Male; D051379:Mice; D010042:Ouabain; D051381:Rats; D017208:Rats, Wistar; D014693:Ventricular Fibrillation / Q000139:chemically induced / Q000517:prevention & control
D000889:Anti-Arrhythmia Agents; D001060:Aporphines; D017609:Barium Compounds; D002712:Chlorides; C024986:barium chloride; D001464:Barium; C061009:crebanine; D010042:Ouabain; D000157:Aconitine