[The gastroprotective and antiaggregant activities of 13-azaprostanoids].
Some 13-azaprostanoic acid derivatives were shown to have a high cytoprotective activity against the damaging effect of ethanol on the gastric mucosa in non-strain rats and affect ATP- and arachidonate-induced platelet aggregation in the whole blood of rabbits and rats in a different way. The gastroprotective activity that is common to natural and synthetic prostanoids is not closely related to the chemical structure of the compounds. On the contrary, the trends of these compounds to affect the induced platelet aggregation depend on the modification of both the cyclic moiety and both chains of a prostanoid molecule.
Kuz'mitskiĭ
B B
BB
Mizulo
N A
NA
Romanova
V N
VN
Malaeva
L P
LP
Khlebnikova
T S
TS
Lakhvich
F A
FA
D000818:Animals; D004353:Drug Evaluation, Preclinical; D000431:Ethanol; D005753:Gastric Mucosa / Q000187:drug effects*; D008297:Male; D010974:Platelet Aggregation / Q000187:drug effects; D010975:Platelet Aggregation Inhibitors / Q000494:pharmacology* / Q000627:therapeutic use; D011466:Prostanoic Acids / Q000494:pharmacology* / Q000627:therapeutic use; D011817:Rabbits; D051381:Rats; D013276:Stomach Ulcer / Q000139:chemically induced / Q000188:drug therapy; D013329:Structure-Activity Relationship
D010975:Platelet Aggregation Inhibitors; D011466:Prostanoic Acids; D000431:Ethanol; C022574:13-azaprostanoic acid
Nekotorye aspekty gastroprotektornoĭ i antiagregatsionnoĭ aktivnosti 13-azaprostanoidov.