FLT4, a novel class III receptor tyrosine kinase in chromosome 5q33-qter.
The receptors for at least two hematopoietic growth factors, namely the stem cell factor and colony-stimulating factor 1, belong to class III receptor tyrosine kinases. Here we describe cloning of a partial complementary DNA for FLT4, an additional member of this gene family from human leukemia cells. The FLT4 tyrosine kinase domain is 79% homologous with the previously cloned FLT1 (M. Shibuya et al., Oncogene, 5: 519-524, 1990) tyrosine kinase and maps to the chromosomal region 5q33-qter. We have found FLT4 expression in human placenta, lung, heart, and kidney, whereas the pancreas and brain appeared to contain very little if any FLT4 RNA. The results suggest that FLT4 functions in multiple adult tissues.
Aprelikova
O
O
Department of Virology, University of Helsinki, Finland.
Pajusola
K
K
Partanen
J
J
Armstrong
E
E
Alitalo
R
R
Bailey
S K
SK
McMahon
J
J
Wasmuth
J
J
Huebner
K
K
Alitalo
K
K
D000328:Adult; D000595:Amino Acid Sequence; D015152:Blotting, Northern; D002871:Chromosome Banding; D002895:Chromosomes, Human, Pair 5; D006801:Humans; D008969:Molecular Sequence Data; D009928:Organ Specificity; D016133:Polymerase Chain Reaction; D011505:Protein-Tyrosine Kinases / Q000235:genetics*; D012333:RNA, Messenger / Q000032:analysis / Q000235:genetics; D011956:Receptors, Cell Surface / Q000235:genetics*; D012689:Sequence Homology, Nucleic Acid
D012333:RNA, Messenger; D011956:Receptors, Cell Surface; D011505:Protein-Tyrosine Kinases