title: Interaction of novel tris-intercalators with DNA. Spectrofluorometric studies.
abstract: Novel DNA binding ligands (1 and its stereoisomer 2) which contain three potentially intercalating units in a linear molecular skeleton were prepared. From a study of the displacement of ethidium bromide from several natural and synthetic polynucleotides, both compounds 1 and 2 were found to show an AT base-pair preference in the interaction with DNAs with 2 a slightly higher affinity for DNA. This result is in sharp contrast to that for acridine and anthraquinone, because these two compounds exhibit a GC-preference.
authors.affiliation: Department of Biochemical Engineering and Science, Faculty of Computer Science and Systems Engineering, Kyushu Institute of Technology, Iizuka, Japan.
authors.forename: S
authors.initials: S
authors.lastname: Takenaka
authors.forename: S
authors.initials: S
authors.lastname: Nishira
authors.forename: H
authors.initials: H
authors.lastname: Kondo
authors.forename: M
authors.initials: M
authors.lastname: Takagi
mesh_terms: D004247:DNA / Q000737:chemistry*; D004996:Ethidium; D007364:Intercalating Agents / Q000737:chemistry*; D015394:Molecular Structure; D013050:Spectrometry, Fluorescence
chemical_list: D007364:Intercalating Agents; D004247:DNA; D004996:Ethidium