Intestinal permeability test in systemic lupus erythematosus.
Using the Cr-51 labeled EDTA resorption test, intestinal permeability was measured in 23 patients with systemic lupus erythematosus and in 16 healthy volunteers. The Cr-51 EDTA intestinal permeability test was adopted from Bjarnason et al, (Gastroenterology 1983; 85:318). 87% (14/16) of the controls had an abnormal permeability test findings (more than 2.6% in 24h). No significant difference was demonstrated between the SLE patients and the controls (SLE = 3.51 +/- 1.66; controls = 4.20 +/- 1.56, P greater than 0.05). Our study indicated that Cr-51 EDTA permeability test failed to distinguish between SLE and normal groups, and that the elevated Cr-51 EDTA excretion in the controls challenged the validity of the test.
Wang
S J
SJ
Department of Nuclear Medicine, Veterans General Hospital-Taichung, Taiwan, R.O.C.
Kao
C H
CH
Chen
D U
DU
Lan
J L
JL
D000293:Adolescent; D000328:Adult; D002860:Chromium Radioisotopes / Q000493:pharmacokinetics; D004492:Edetic Acid / Q000493:pharmacokinetics; D005260:Female; D006801:Humans; D007413:Intestinal Mucosa / Q000378:metabolism*; D008180:Lupus Erythematosus, Systemic / Q000378:metabolism*; D008297:Male; D010539:Permeability
D002860:Chromium Radioisotopes; D004492:Edetic Acid