title: Selection of permethrin resistance in the malaria vector Anopheles stephensi.
abstract: The laboratory strain of Anopheles stephensi, a well-known urban malaria vector, was selected with permethrin, a synthetic pyrethroid at LD90 level up to five generations. The selection resulted in the development of resistance in F5 generation to the tune of 13-fold to permethrin and cross-resistance to the tune of 7-fold to cypermethrin, 9-fold to alphamethrin, and 10-fold to deltamethrin. The development of cross-resistance to 4% DDT was also noticed. The susceptibility status against 5% malathion was maintained throughout the five generations. The synergistic effect of piperonyl butoxide with permethrin did not overcome the development of resistance. The development of resistance showed a significant relationship between hatchability and different generations.
authors.affiliation: Vector Control Research Centre, Indira Nagar, Medical Complex Pondicherry, India.
authors.forename: B C
authors.initials: BC
authors.lastname: Chakravorthy
authors.forename: M
authors.initials: M
authors.lastname: Kalyanasundaram
mesh_terms: D000818:Animals; D000852:Anopheles; D006801:Humans; D007303:Insect Vectors; D007305:Insecticide Resistance; D007306:Insecticides; D007928:Lethal Dose 50; D008288:Malaria / Q000635:transmission; D008297:Male; D009570:Nitriles; D026023:Permethrin; D011722:Pyrethrins; D013045:Species Specificity
chemical_list: D007306:Insecticides; D009570:Nitriles; D011722:Pyrethrins; C017160:cypermethrin; C017180:decamethrin; D026023:Permethrin