[The mechanisms of the manifestation of the genotoxic effects of binase].
The high concentrations of commercial sample of Bacillus intermedius 7P ribonuclease (binase) showed a weak mutagenic effect in Ames test and Ara-test. It has been established that binase induces the SOS-functions of microbial cell and prophage induction. The way of exogenic enzyme action through activation of RecA protein is proposed.
Ivanchenko
O B
OB
Il'inskaia
O N
ON
Karamova
N S
NS
Cherepneva
I E
IE
D001407:Bacillus / Q000201:enzymology; D001412:Bacillus subtilis / Q000187:drug effects / Q000254:growth & development; D004722:Endoribonucleases / Q000633:toxicity*; D004926:Escherichia coli / Q000187:drug effects* / Q000235:genetics; D005798:Genes, Bacterial / Q000187:drug effects* / Q000235:genetics; D009152:Mutagenicity Tests; D009154:Mutation / Q000187:drug effects / Q000235:genetics; D013014:SOS Response, Genetics / Q000187:drug effects; D012486:Salmonella typhimurium / Q000187:drug effects* / Q000235:genetics; D013302:Streptomyces / Q000187:drug effects / Q000254:growth & development; D014775:Virus Activation / Q000187:drug effects
D004722:Endoribonucleases; C022543:ribonuclease T(2)
Mekhanizmy proiavleniia genotoksicheskikh éffektov binazy.