Human interleukin-9: a new cytokine in hematopoiesis.
IL-9 was first identified in the mouse system as a T cell growth factor while human IL-9 was isolated based on its activity on a human myeloid leukemic cell line. The high sequence homology between mouse and human IL-9 plus the preliminary biological analysis have predicted a wide spectrum of in vitro biological activities for this cytokine. Despite the high sequence homology between mouse and human IL-9, many biological activities, however, have not been demonstrated in both species. In vivo studies therefore become essential to understand the physiological role of IL-9. Increasing evidence have also suggested the possible role of IL-9 in the pathogenesis of HD and LCAL. Detailed analysis of IL-9 expression, autocrine growth and clinical outcome of HD patients will be required to make any speculation on the role of this cytokine in the disease states.
Yang
Y C
YC
Department of Medicine, Indiana University School of Medicine, Indianapolis.
D000818:Animals; D002874:Chromosome Mapping; D015870:Gene Expression; D006410:Hematopoiesis / Q000187:drug effects*; D006801:Humans; D007136:Immunoglobulins / Q000096:biosynthesis; D016906:Interleukin-9 / Q000235:genetics / Q000494:pharmacology* / Q000502:physiology; D007938:Leukemia / Q000209:etiology; D008223:Lymphoma / Q000209:etiology; D051379:Mice; D008934:Mitogens / Q000494:pharmacology; D015398:Signal Transduction; D014407:Tumor Cells, Cultured
D007136:Immunoglobulins; D016906:Interleukin-9; D008934:Mitogens