title: Evolution of secondary metabolite production: potential roles for antibiotics as prebiotic effectors of catalytic RNA reactions.
abstract: It has been proposed that organic molecules related to known secondary metabolites have existed since the beginning of biochemical evolution and were present in primordial soups. Under primitive earth conditions certain of these molecules may have played roles as effectors in prebiotic reactions, especially those involving catalytic RNA (ribozymes). We demonstrate that a number of antibiotic-related secondary metabolites bind to group I introns and either inhibit splicing reactions or promote the formation of intron oligomers. This is consistent with the functional co-evolution of catalytic RNA and secondary metabolites as antibiotic inhibitors of translation, and supports the notion of an evolutionary relationship between group I introns and ribosomal RNA.
authors.affiliation: Department of Microbiology, University of British Columbia, Vancouver, Canada.
authors.forename: J
authors.initials: J
authors.lastname: Davies
authors.forename: U
authors.initials: U
authors.lastname: von Ahsen
authors.forename: H
authors.initials: H
authors.lastname: Wank
authors.forename: R
authors.initials: R
authors.lastname: Schroeder
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D005075:Biological Evolution; D007438:Introns / Q000502:physiology; D000069497:Origin of Life; D016337:RNA, Catalytic / Q000378:metabolism*
chemical_list: D000900:Anti-Bacterial Agents; D016337:RNA, Catalytic