title: 3-Diazopyrroles. Part 5 (1). Antibacterial activity of 3-diazo-2-phenylpyrroles.
abstract: 3-Diazo-2-phenylpyrroles 3a-g showed antimicrobial activity against Gram-positive bacteria, whereas against Gram-negative strains the inhibitory activity is limited to derivatives 3a and 3c. The substituents at 4 and 5 positions strongly influence the inhibitory activity, but the presence of the diazo group is crucial for appearance of activity.
authors.affiliation: Istituto Farmacochimico, Università, Palermo, Italy.
authors.forename: G
authors.initials: G
authors.lastname: Cirrincione
authors.forename: A M
authors.initials: AM
authors.lastname: Almerico
authors.forename: G
authors.initials: G
authors.lastname: Dattolo
authors.forename: E
authors.initials: E
authors.lastname: Aiello
authors.forename: S
authors.initials: S
authors.lastname: Grimaudo
authors.forename: P
authors.initials: P
authors.lastname: Diana
authors.forename: F
authors.initials: F
authors.lastname: Misuraca
mesh_terms: D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D004926:Escherichia coli / Q000187:drug effects; D009682:Magnetic Resonance Spectroscopy; D008826:Microbial Sensitivity Tests; D011758:Pyrroles / Q000138:chemical synthesis* / Q000494:pharmacology; D013056:Spectrophotometry, Ultraviolet; D013302:Streptomyces / Q000187:drug effects
chemical_list: D000900:Anti-Bacterial Agents; D011758:Pyrroles