Rhabdomyolysis accompanying thyroid crisis: an autopsy case report.
Rhabdomyolysis is occasionally associated with metabolic disorders such as diabetic coma, severe electrolyte disturbances and myxedema coma. We describe rhabdomyolysis accompanying thyroid crisis. A 50-year-old man with Graves' disease developed rhabdomyolysis, congestive heart failure and hepatic failure during the course of thyroid crisis and then died of acute renal failure. Postmortem examination revealed rhabdomyolysis in the cardiac and psoas muscles, old myocardial infarction, hepatic centrilobular necrosis, renal cortical necrosis, and follicular hyperplasia in the thyroid. Circulatory collapse and dehydration under excessive hypermetabolic state presumably suppressed the source of energy and oxygen for muscle cells, leading to cellular damage.
Hosojima
H
H
Department of Internal Medicine, Kanazawa Medical University, Uchinada, Japan.
Iwasaki
R
R
Miyauchi
E
E
Okada
H
H
Morimoto
S
S
D000305:Adrenal Cortex Hormones / Q000097:blood; D000311:Adrenal Glands / Q000378:metabolism; D006111:Graves Disease / Q000150:complications; D006333:Heart Failure / Q000209:etiology; D006801:Humans; D017114:Liver Failure, Acute / Q000209:etiology; D008297:Male; D008875:Middle Aged; D012206:Rhabdomyolysis / Q000150:complications / Q000175:diagnosis* / Q000209:etiology / Q000473:pathology; D013958:Thyroid Crisis / Q000150:complications / Q000175:diagnosis* / Q000209:etiology; D013961:Thyroid Gland / Q000473:pathology; D013963:Thyroid Hormones / Q000097:blood
D000305:Adrenal Cortex Hormones; D013963:Thyroid Hormones