title: Plasmid copy number control: a case study of the quasi-steady-state assumption.
abstract: Perelson & Brendel (1989, J. molec. Biol. 208, 245-255) have proposed kinetic models for the control of plasmid copy number, based on experiments by J. Tomizawa and his associates. The quasi-steady-state assumptions (QSSA) made in the analysis of these models are justified in the present paper, thereby providing an example of how QSSA can provide a powerful and reliable tool in the analysis of biological kinetics.
authors.affiliation: Department of Applied Mathematics and Computer Science, Weizmann Institute, Rehovot, Israel.
authors.forename: L A
authors.initials: LA
authors.lastname: Segel
authors.forename: A S
authors.initials: AS
authors.lastname: Perelson
mesh_terms: D008957:Models, Genetic; D010957:Plasmids / Q000235:genetics*