Surfactin/iturin A interactions may explain the synergistic effect of surfactin on the biological properties of iturin A.
Iturin A and surfactin are two lipopeptides extracted from a same strain of Bacillus subtilis. Iturin A possesses antibiotic and antifungal activities and surfactin is a strong surfactant. The presence of surfactin, at a concentration at which, alone, it is inactive, increases to a very large extent the haemolysis percent induced by iturin A. This synergistic effect seems to be in relation with interactions between iturin A and surfactin. Iturin A adsorbs to and penetrates into surfactin monolayers. Iturin A and surfactin are miscible and interact specifically in mixed monolayers.
Maget-Dana
R
R
Centre de Biophysique Moléculaire, CNRS, Orléans, France.
Thimon
L
L
Peypoux
F
F
Ptak
M
M
D000327:Adsorption; D000595:Amino Acid Sequence; D000900:Anti-Bacterial Agents; D000903:Antibiotics, Antineoplastic / Q000737:chemistry / Q000494:pharmacology*; D000935:Antifungal Agents / Q000737:chemistry / Q000494:pharmacology*; D001426:Bacterial Proteins / Q000737:chemistry / Q000494:pharmacology*; D004347:Drug Interactions; D004357:Drug Synergism; D004912:Erythrocytes / Q000187:drug effects; D006461:Hemolysis / Q000187:drug effects*; D006801:Humans; D055666:Lipopeptides; D008969:Molecular Sequence Data; D010455:Peptides; D010456:Peptides, Cyclic / Q000737:chemistry / Q000494:pharmacology
D000900:Anti-Bacterial Agents; D000903:Antibiotics, Antineoplastic; D000935:Antifungal Agents; D001426:Bacterial Proteins; D055666:Lipopeptides; D010455:Peptides; D010456:Peptides, Cyclic; C009365:surfactin peptide; C013579:iturin A