[Tobacco, drug and narcotic abuse during pregnancy. Evaluation of in utero exposure by analysis of hair of the neonate].
Hair samples were collected at the time of delivery from 63 neonates whose mothers were known to be heroin (9 cases), nicotine (40 cases), benzodiazepines (11 cases), cocaine (2 cases) and amphetamine (1 case) users. In all cases, the corresponding drug was found in neonatal hair from the infants, with concentrations in the range 0.61-3.47 ng/mg (morphine), 0.15-11.80 ng/mg (nicotine), 3.36-17.55 ng/mg (diazepam), 0.78-31.83 ng/mg (oxazepam), 0.71-2.47 ng/mg (benzoylecgonine), and 1.21 ng/mg (amphetamine). A significant correlation (P < 0.001) was established between nicotine concentration in the hair of the neonates, and in the hair of their mother.
Kintz
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P
Institut de Médecine légale, Strasbourg.
Tracqui
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A
Mangin
P
P
D000014:Abnormalities, Drug-Induced / Q000209:etiology; D000661:Amphetamine / Q000009:adverse effects / Q000032:analysis; D001569:Benzodiazepines / Q000009:adverse effects / Q000032:analysis*; D003042:Cocaine / Q000009:adverse effects / Q000032:analysis*; D005260:Female; D005317:Fetal Growth Retardation / Q000139:chemically induced; D006197:Hair / Q000737:chemistry*; D006801:Humans; D007231:Infant, Newborn; D009020:Morphine / Q000009:adverse effects / Q000032:analysis*; D009538:Nicotine / Q000009:adverse effects / Q000032:analysis*; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects; D012907:Smoking / Q000009:adverse effects*; D019966:Substance-Related Disorders
D001569:Benzodiazepines; D009538:Nicotine; D009020:Morphine; D000661:Amphetamine; D003042:Cocaine
Tabac, médicaments et stupéfiants pendant la grossesse. Evaluation de l'exposition in utero par analyse des cheveux du nouveau-né.