[Clinical evaluation of the metabolism and imaging of the lung in the patients with chronic obstructive pulmonary diseases using 131I-HIPDM].
The accumulation of venously injected 131I-HIPDM in the rat lung was observed. In this article we report the results of application of 131I-HIPDM in the patients with COPD. The results showed that the metabolism and development of 131I-HIPDM in the lung reflected on condition of the pulmonary endothelial cells or receptors. The clearance curve of HIPDM displayed that COPD, especially COPD of smokers was slow. The analysis of the lung clearance of 131I-HIPDM forms a new index of lung dysfunction.
Liu
C T
CT
General Hospital of PLA.
D000328:Adult; D000368:Aged; D000818:Animals; D001249:Asthma / Q000000981:diagnostic imaging; D005260:Female; D006801:Humans; D007457:Iodine Radioisotopes / Q000493:pharmacokinetics; D007462:Iodobenzenes / Q000493:pharmacokinetics; D008168:Lung / Q000000981:diagnostic imaging* / Q000378:metabolism*; D008173:Lung Diseases, Obstructive / Q000000981:diagnostic imaging*; D008297:Male; D008657:Metabolic Clearance Rate; D008875:Middle Aged; D011877:Radionuclide Imaging; D051381:Rats; D017207:Rats, Sprague-Dawley; D012907:Smoking
D007457:Iodine Radioisotopes; D007462:Iodobenzenes; C036739:N,N,N'-trimethyl-N'-(2-hydroxy-3-methyl-5-iodobenzyl)-1,3-propanediamine