Relative bioavailability in man of noscapine administered in lozenges and mixture.
The bioavailability of noscapine base administered in lozenges in a dose of 100 mg to twelve healthy volunteers, in a study using an open balanced cross-over design, was compared with that of 100 mg of noscapine hydrochloride given perorally as a mixture. The bioavailability of noscapine after administration in lozenges was significantly higher than that after administration of the drug as a mixture. It is concluded that the lozenges containing noscapine base may be a valuable alternative to the conventional noscapine hydrochloride mixture.
Jensen
L N
LN
Royal Danish School of Pharmacy, Department of Pharmaceutics, Universitetsparken, Copenhagen.
Christrup
L L
LL
Jacobsen
L
L
Bonde
J
J
Bundgaard
H
H
D000328:Adult; D001682:Biological Availability; D005260:Female; D006801:Humans; D008297:Male; D009665:Noscapine / Q000008:administration & dosage / Q000493:pharmacokinetics*; D012996:Solutions; D013607:Tablets
D012996:Solutions; D013607:Tablets; D009665:Noscapine