[Effect of rifampicin on the synthesis of antibodies to fraction I of vaccine EV].
Multifactorial analysis was used to study the influence of rifampicin on the dynamics of synthesis of antibodies belonging to IgM and IgG classes in mice immunized by fraction I of the vaccinal strain EV. Equations and quadric surfaces describing individual dynamics of antibody formation within a wide range of antibiotic doses and time of antibody content determination were developed by the experimental data. It was shown that within the range of the doses corresponding to the therapeutic ones in man rifampicin stimulated antibody formation. It had an inhibitory effect on antibody genesis only when used in the doses many times higher than the therapeutic ones.
Nikitin
A V
AV
Smolkina
T V
TV
Zebrev
A I
AI
Fishman
V M
VM
Prokof'ev
M M
MM
Astashkina
V L
VL
D000818:Animals; D000917:Antibody Formation / Q000187:drug effects; D001428:Bacterial Vaccines / Q000276:immunology*; D005591:Chemical Fractionation; D003198:Computer Simulation; D004305:Dose-Response Relationship, Drug; D007124:Immunoenzyme Techniques; D007074:Immunoglobulin G / Q000096:biosynthesis*; D007075:Immunoglobulin M / Q000096:biosynthesis*; D008297:Male; D051379:Mice; D008808:Mice, Inbred CBA; D012293:Rifampin / Q000494:pharmacology*
D001428:Bacterial Vaccines; D007074:Immunoglobulin G; D007075:Immunoglobulin M; D012293:Rifampin
Vliianie rifampitsina na sintez antitel k I fraktsii vaktsiny EV.