Chemosensitivity of salivary gland and oral cancer cell lines.
Chemosensitivity of salivary gland and oral cancer cell lines to 14 antitumor drugs was tested using a tetrazolium-based colorimetric assay and the relative antitumor activity (RAA) of the drugs was compared. Adriamycin (ADM), methotrexate and fluorouracil (5-FU) showed the most potent RAA against the cell lines while cantharidin did not. The rank orders of other 10 drugs against each cell line differed from each other.
Wu
J Z
JZ
Central Laboratory, Stomatological Hospital, Fourth Military Medical University, Xi'an.
Situ
Z Q
ZQ
Chen
J Y
JY
Liu
B
B
Wang
W
W
D002193:Cantharidin / Q000494:pharmacology; D004317:Doxorubicin / Q000494:pharmacology*; D005472:Fluorouracil / Q000494:pharmacology*; D006801:Humans; D008727:Methotrexate / Q000494:pharmacology*; D009062:Mouth Neoplasms / Q000473:pathology*; D012468:Salivary Gland Neoplasms / Q000473:pathology*; D014407:Tumor Cells, Cultured / Q000187:drug effects; D014410:Tumor Stem Cell Assay
D004317:Doxorubicin; D002193:Cantharidin; D005472:Fluorouracil; D008727:Methotrexate