[The use of diksafen for curing the neurotoxic reactions of cancer patients undergoing radiation and chemotherapy].
The paper discusses a clinical trial of a newly developed Soviet preparation--dixaphen which was administered to 40 patients who had received radiation and chemotherapy for Hodgkin's disease and tumors at other sites. A single intramuscular injection of 1.0 ml was found to abort emesis in 80-90% and asthenic syndrome--in 60-75%. The drug was well tolerated; it is recommended for treatment of malignant tumors.
Legeza
V I
VI
Korytova
L I
LI
Rakhmilevich
B M
BM
Rambovskiĭ
A I
AI
D000293:Adolescent; D000328:Adult; D000932:Antiemetics / Q000627:therapeutic use*; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects; D001247:Asthenia / Q000188:drug therapy / Q000209:etiology; D001549:Benzamides / Q000627:therapeutic use*; D002110:Caffeine / Q000627:therapeutic use*; D003131:Combined Modality Therapy; D004338:Drug Combinations; D004341:Drug Evaluation; D004809:Ephedrine / Q000627:therapeutic use*; D005767:Gastrointestinal Diseases / Q000188:drug therapy / Q000209:etiology; D006801:Humans; D008875:Middle Aged; D009369:Neoplasms / Q000150:complications / Q000188:drug therapy* / Q000532:radiotherapy*; D009420:Nervous System / Q000187:drug effects* / Q000528:radiation effects*; D011878:Radiotherapy / Q000009:adverse effects
D000932:Antiemetics; D001549:Benzamides; D004338:Drug Combinations; C080944:dixaphen; D002110:Caffeine; C037141:dimetpramid; D004809:Ephedrine
Primenenie diksafena dlia kupirovaniia neĭrotoksicheskikh reaktsiĭ u onkologicheskikh bol'nykh, podvergaiushchikhsia luchevoĭ i khimioterapii.