title: [Gingival crevicular aspartate aminotransferase levels in periodontitis patients before and after periodontal treatment].
abstract: Gingival crevicular fluid samples were collected from 296 teeth from 40 subjects, including 19 rapidly progressive periodontitis (RPP), 8 chronic adult periodontitis (CAP), 7 marginal gingivitis (MG) and 6 healthy subjects (H). The activities of aspartate aminotransferase (AST) in each sample were tested. The results were as follows: (1) The two groups with destructive periodontal disease (RPP and CAP) had greater GCF-AST levels than that from the two non-destructive groups (MG and H). (2) The GCF-AST activities showed significant positive correlations with clinical periodontal parameters, such as probing depth, attachment loss, bleeding index and suppuration. (3) Four weeks after thorough full-mouth root planing, both clinical parameters and GCF-AST levels decreased significantly. The present study suggests that GCF-AST activity might be a sensitive and objective marker for detection of periodontal tissue destruction and inflammation.
authors.affiliation: School of Stomatology, Beijing Medical University.
authors.forename: R
authors.initials: R
authors.lastname: Li
mesh_terms: D000328:Adult; D001219:Aspartate Aminotransferases / Q000378:metabolism*; D005883:Gingival Crevicular Fluid / Q000201:enzymology*; D005891:Gingivitis / Q000201:enzymology; D006801:Humans; D008875:Middle Aged; D010518:Periodontitis / Q000201:enzymology* / Q000628:therapy
chemical_list: D001219:Aspartate Aminotransferases