[The fever reaction of the polecat Mustela putorius x Mustela putorius furo to a bacterial pyrogen: the hypo- and hyperthermic phases].
It has been demonstrated that the ferret (Mustela putorius x Mustela putorius furo) responds to intramuscular injection of Salmonella typhi lipopolysaccharide (30 ng/kg-100 micrograms/kg) by biphasic change in the body temperature (Tb): the initial decrease in the latter is followed by hyperthermia. Maximum rise in Tb (1.6 +/- 0.1 degrees C) was observed after the injection of lipopolysaccharide in the highest dose. Rabbit leucocytic pyrogen/interleukin-1 (1 ml from 3.5 x 10(7) peritoneal phagocytes, 3 ml/kg) induces a pronounced (1.1 +/- 0.3 degrees C) decrease in Tb. Mechanisms of hypothermic effects of pyrogens are discussed. The described pattern (hypothermia-hyperthermia) of Tb response to lipopolysaccharide in the ferret presumably reflects the central thermoregulatory process which is the same for different changes in Tb during fever.
Romanovskiĭ
A A
AA
Karman
E K
EK
Gurin
V N
VN
D000818:Animals; D001831:Body Temperature / Q000187:drug effects; D001833:Body Temperature Regulation / Q000187:drug effects; D005289:Ferrets / Q000502:physiology*; D005334:Fever / Q000139:chemically induced* / Q000503:physiopathology; D007035:Hypothermia / Q000139:chemically induced* / Q000503:physiopathology; D007273:Injections, Intramuscular; D007279:Injections, Subcutaneous; D007375:Interleukin-1 / Q000008:administration & dosage*; D008070:Lipopolysaccharides / Q000008:administration & dosage*; D008297:Male; D011749:Pyrogens / Q000008:administration & dosage*; D011817:Rabbits; D012007:Rectum; D012485:Salmonella typhi
D007375:Interleukin-1; D008070:Lipopolysaccharides; D011749:Pyrogens
Likhoradochnaia reaktsiia khoria Mustela putorius x Mustela putorius furo na bakterial'nyĭ pirogen: gipo- i gipertermicheskaia fazy.