title: [Granulocyte-specific and HLA antibodies in pregnancy: incidence and clinical value].
abstract: Postpartum sera of 1,016 unselected women were examined for granulocyte-specific and HLA antibodies. A total of 11 out of 1,016 sera (1.1%) were only reactive with neutrophils. Cytotoxic HLA antibodies were detected in 24%, noncytotoxic HLA antibodies in 4.8% of the sera. All antibodies belonged to the IgG 1 and IgG 3 subclasses. NA1 and NB1 specificity were each determined in one serum, two sera contained NA2-specific antibodies. After 1 year all antibodies were no more detectable. As none of the newborns from immunized mothers developed neutropenia, the incidence of alloimmune neonatal neutropenia seems to be lower than 0.1%.
authors.affiliation: Institut für Klinische Immunologie und Transfusionsmedizin, Klinikum der Justus-Liebig-Universität Giessen, BRD.
authors.forename: J
authors.initials: J
authors.lastname: Bux
authors.forename: K D
authors.initials: KD
authors.lastname: Jung
authors.forename: G
authors.initials: G
authors.lastname: Mueller-Eckhardt
authors.forename: C
authors.initials: C
authors.lastname: Mueller-Eckhardt
mesh_terms: D001327:Autoimmune Diseases / Q000097:blood*; D001787:Blood Group Incompatibility / Q000097:blood; D005260:Female; D005455:Fluorescent Antibody Technique; D006098:Granulocytes / Q000276:immunology*; D006680:HLA Antigens / Q000276:immunology; D006801:Humans; D007231:Infant, Newborn; D007518:Isoantibodies / Q000097:blood*; D007519:Isoantigens / Q000276:immunology*; D015997:Neonatal Screening; D009503:Neutropenia / Q000097:blood*; D011247:Pregnancy
chemical_list: D006680:HLA Antigens; D007518:Isoantibodies; D007519:Isoantigens
vernacular_title: Granulozytenspezifische und HLA-Antikörper während der Schwangeschaft: Häufigkeit und klinische Bedeutung.