Anemia in experimental visceral leishmaniasis in hamsters.
Experimental infection of hamsters with Leishmania donovani caused visceral leishmaniasis in which hematological changes occurred. The infected hamsters were anemic and reticulocyte counts were high. No significant change in the serum erythropoietin level was noted. Red cell membrane Na(+)-K(+)-ATPase and acetylcholinesterase activities increased. Osmotic fragility of the erythrocytes from infected animals increased. The level of 2,3-diphosphoglycerate of the red cells increased with the degree of anemia.
Biswas
T
T
Department of Immunochemistry, Indian Institute of Chemical Biology, Jadavpur, Calcutta.
Chakraborty
M
M
Naskar
K
K
Ghosh
D K
DK
Ghosal
J
J
D019794:2,3-Diphosphoglycerate; D000110:Acetylcholinesterase / Q000097:blood; D000740:Anemia / Q000097:blood / Q000209:etiology*; D000818:Animals; D006224:Cricetinae; D004163:Diphosphoglyceric Acids / Q000097:blood; D004910:Erythrocyte Membrane / Q000201:enzymology; D004912:Erythrocytes / Q000737:chemistry; D004921:Erythropoietin / Q000097:blood; D006454:Hemoglobins / Q000032:analysis; D007898:Leishmaniasis, Visceral / Q000097:blood / Q000150:complications*; D009996:Osmotic Fragility; D000254:Sodium-Potassium-Exchanging ATPase / Q000097:blood
D004163:Diphosphoglyceric Acids; D006454:Hemoglobins; D004921:Erythropoietin; D019794:2,3-Diphosphoglycerate; D000110:Acetylcholinesterase; D000254:Sodium-Potassium-Exchanging ATPase