[The effect of beta-carotene on interleukin-2 production and mitogen-induced proliferation of T-lymphocytes].
Interleukin-2 (IL-2) production followed by with aftereffect of the immunosuppressive agent hydrocortisone and mitogen-induced proliferation of T lymphocytes were studied in the presence of artificial beta-carotene. Treatment of CBA mice with the drug was performed within various periods. beta-Carotene was found to elevate IL-2 secretion and the effect was both time- and dose-dependent. The drug removed immunosuppression developed after intraperitoneal administration of hydrocortisone. At the same time, beta-carotene stimulated mitogen-induced proliferation of T cells, which was dose-dependent.
Buiuklinskaia
O V
OV
Korostelev
S A
SA
Potapova
A A
AA
Sergeev
S A
SA
Uteshev
B S
BS
D000818:Animals; D002338:Carotenoids / Q000494:pharmacology*; D002455:Cell Division / Q000187:drug effects*; D006854:Hydrocortisone / Q000494:pharmacology; D007376:Interleukin-2 / Q000096:biosynthesis*; D008297:Male; D051379:Mice; D008808:Mice, Inbred CBA; D008934:Mitogens; D013601:T-Lymphocytes / Q000166:cytology / Q000187:drug effects*; D019207:beta Carotene
D007376:Interleukin-2; D008934:Mitogens; D019207:beta Carotene; D002338:Carotenoids; D006854:Hydrocortisone
Vlianie beta-karotina na produktsiiu interleĭkina-2 i mitogenindutsirovannuiu proliferatsiiu T-limfotsitov.