Pharmacokinetics of amikacin in gamma-irradiated mice.
Concentrations of amikacin in sera, investigated 24 h after irradiation with 9 Gy gamma-rays of mice, were monitored using TDX system (Abbott), based on the fluorescence polarization immunoassay. Pharmacokinetic parameters of disposition (distribution + elimination) of the drug were calculated from the obtained data. In irradiated mice fast and slow phases of amikacin disposition were noted. In contrary, in the non irradiated mice only one-fast phase of the drug disposition was observed. The dependence of the disposition parameters of the antibiotic to the postirradiation tubular dystrophia and vascular changes was discussed.
Lipski
S
S
Department of Radiation Protection, Institute of Hygiene and Epidemiology, Warszawa, Poland.
Gasiewski
A
A
Chaś
J
J
D000583:Amikacin / Q000097:blood / Q000493:pharmacokinetics*; D000818:Animals; D005454:Fluorescence Polarization; D005720:Gamma Rays; D007684:Kidney Tubules / Q000528:radiation effects*; D008297:Male; D051379:Mice; D008809:Mice, Inbred C3H; D011833:Radiation Injuries, Experimental / Q000378:metabolism*; D014018:Tissue Distribution
D000583:Amikacin