[The comparative characteristics of the effect of piracetam peptide analogs on the recovery of conditioned reflex activity in animals following damage to the frontal cortex and the electrophysiological characteristics of the brain integrative activity].
The time course of recovery of a conditioned avoidance response (CAAR) after extirpation of brain frontal regions was examined in rat experiments. The reference nootropic drug piracetam given in a dose 200 mg/g for 9 days after surgery promoted CAAR recovery. The original peptide analogue of piracetam--pyroglutamyl-D-alanine amide (I)--produced the same effect when given in a dose of 1 mg/kg. Another peptide analogue of piracetam--pyroglutamyl-asparagine amide (II) showed no promoting effect on CAAR recovery after frontal lobectomy. Electrophysiological experiments have demonstrated that I promotes the transcallosal cortical responses to a greater extent than does II. It has been suggested that the most significant promoting effect on the compensatory and recovery process after frontal lobectomy is produced by the nootropic compounds which have a promoting effect on memory trace consolidation.
Romanova
G A
GA
Gudasheva
T A
TA
Dobrynin
V P
VP
Ostrovskaia
R U
RU
D000818:Animals; D001362:Avoidance Learning / Q000187:drug effects; D002415:Cats; D003214:Conditioning, Classical / Q000187:drug effects*; D003337:Corpus Callosum / Q000187:drug effects / Q000502:physiology; D004151:Dipeptides / Q000494:pharmacology*; D004558:Electric Stimulation; D005073:Evoked Potentials, Somatosensory / Q000187:drug effects; D005625:Frontal Lobe / Q000502:physiology* / Q000601:surgery; D008297:Male; D010889:Piracetam / Q000031:analogs & derivatives* / Q000494:pharmacology; D011761:Pyrrolidonecarboxylic Acid / Q000031:analogs & derivatives*; D011826:Radial Nerve / Q000502:physiology; D051381:Rats
D004151:Dipeptides; C054344:pyroglutamylalanine amide; C081772:pyroglutamyl-asparaginamide; D011761:Pyrrolidonecarboxylic Acid; D010889:Piracetam
Sravnitel'naia kharakteristika vliianiia peptidnykh analogov piratsetama na vosstanovlenie uslovnoreflektornoĭ deiatel'nosti zhivotnykh posle povrezhdeniia frontal'noĭ kory i élektrofiziologicheskie kharakteristiki integrativnoĭ deiatel'nosti mozga.