title: [Vitrectomy combined with intravitreal injection of drugs for the management of advanced suppurative endophthalmitis].
abstract: Sixty cases (60 eyes) of advanced suppurative endophthalmitis treated by a combination of vitrectomy and intravitreal injection of drugs (antibiotics or/and corticosteroids) were investigated perspectively. Of the 60 cases, 43 were infected after trauma, 12 were infected after surgical procedures, while the others were of unknown causes. During the follow-up period of 1/2-5 years, 57 cases (95%) retained functioning eyes, the postoperative visual acuity of 34 eyes (57%) being 0.05 or better and the postoperative visual acuity of 17 eyes (28%) 0.4 to 1.0. The advantages of the therapeutic regimen are analyzed. We believe that it is the most effective therapy for suppurative endophthalmitis. The timing of the operation and the factors influencing the results are discussed. This report also presents our clinical experiences in the management of advanced suppurative endophthalmitis.
authors.affiliation: Zhongshan Ophthalmic Center, Sun Yat-Sen University of Medical Sciences, Guangzhou, China.
authors.forename: X
authors.initials: X
authors.lastname: Wen
authors.forename: G
authors.initials: G
authors.lastname: Zhong
authors.forename: Z
authors.initials: Z
authors.lastname: Wang
authors.forename: X
authors.initials: X
authors.lastname: Wen
authors.forename: Z
authors.initials: Z
authors.lastname: Liu
authors.forename: Y
authors.initials: Y
authors.lastname: Zhou
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D001412:Bacillus subtilis / Q000302:isolation & purification; D002648:Child; D002675:Child, Preschool; D003907:Dexamethasone / Q000008:administration & dosage*; D009877:Endophthalmitis / Q000382:microbiology / Q000628:therapy*; D005260:Female; D005839:Gentamicins / Q000008:administration & dosage*; D006090:Gram-Negative Bacteria / Q000302:isolation & purification; D006801:Humans; D015552:Injections, Intralesional; D008297:Male; D008875:Middle Aged; D013212:Staphylococcus epidermidis / Q000302:isolation & purification; D014821:Vitrectomy
chemical_list: D005839:Gentamicins; D003907:Dexamethasone