Bacterial endotoxins as potential antitumor agents. Tumor mass loss in mice treated with bacterial lipopolysaccharides of Shigella dysenteriae serovar 1.
Natural and modified preparations of lipopolysaccharides and lipopolysaccharide-protein complexes isolated from the S- and R-form of Shigella dysenteriae serovar 1 were found to markedly inhibit the initial growth of mouse solid tumors derived from Németh-Kellner lymphoma, Gardner 6C3HED lymphoma, an ill-defined syngeneic lymphoma of DBA mice (Skalsky lymphoma) and LP-2 plasmacytoma. The biopreparations were given intraperitoneally, most frequently at a dose range from 50 to 200 micrograms per mouse; significant inhibitory effects on tumor growth were evidenced even in mice bearing tumors weighing 113 to 507 mg.
Sourek
J
J
Institute of Hygiene and Epidemiology, Prague, Czechoslovakia.
Oravec
C
C
Männel
D S
DS
D000818:Animals; D000970:Antineoplastic Agents / Q000008:administration & dosage / Q000302:isolation & purification / Q000627:therapeutic use; D001426:Bacterial Proteins / Q000008:administration & dosage / Q000302:isolation & purification / Q000627:therapeutic use; D005069:Evaluation Studies as Topic; D005260:Female; D008070:Lipopolysaccharides / Q000008:administration & dosage / Q000302:isolation & purification / Q000627:therapeutic use*; D008223:Lymphoma / Q000473:pathology / Q000628:therapy*; D051379:Mice; D008815:Mice, Inbred Strains; D012762:Shigella dysenteriae
D000970:Antineoplastic Agents; D001426:Bacterial Proteins; D008070:Lipopolysaccharides