Acute effects of experimental diabetes on skeletal muscle contractile functions.
The study was planned to explore the short term effects of experimental diabetes on the contractile characteristics of soleus and diaphragm. Experimental diabetes was induced in rats by streptozotocin (50 mg/kg, IP). On the 5th day, the isometric contractions were studied in soleus (in situ) and in diaphragm strip (in vitro). The soleus of the diabetic group showed similar twitch characteristics and tetanic tensions, decreased maximal relaxation rate (MRR; p < 0.01) and increased endurance time (ET; p < 0.05) as compared to the control group. The diaphragm of the diabetic group showed greater twitch tension (p < 0.05) and tetanic tension (p < 0.01), increased MRR (p < 0.02) and similar ET compared to the control group. It is concluded that the streptozotocin-induced diabetic state produces differential effects on the skeletal muscle contractile characteristics.
Krishnamurthy
N
N
Department of Physiology, Jawaharlal Institute of Postgraduate Medical Education and Research, Pondicherry, India.
Balakumar
B
B
Thombre
D P
DP
D000818:Animals; D003921:Diabetes Mellitus, Experimental / Q000503:physiopathology*; D003964:Diaphragm; D004594:Electrophysiology; D066298:In Vitro Techniques; D008297:Male; D009119:Muscle Contraction; D009126:Muscle Relaxation; D051381:Rats