Control of the peroxisomal beta-oxidation pathway by a novel family of nuclear hormone receptors.
Three novel members of the Xenopus nuclear hormone receptor superfamily have been cloned. They are related to each other and similar to the group of receptors that includes those for thyroid hormones, retinoids, and vitamin D3. Their transcriptional activity is regulated by agents causing peroxisome proliferation and carcinogenesis in rodent liver. All three Xenopus receptors activate the promoter of the acyl coenzyme A oxidase gene, which encodes the key enzyme of peroxisomal fatty acid beta-oxidation, via a cognate response element that has been identified. Therefore, peroxisome proliferators may exert their hypolipidemic effects through these receptors, which stimulate the peroxisomal degradation of fatty acids. Finally, the multiplicity of these receptors suggests the existence of hitherto unknown cellular signaling pathways for xenobiotics and putative endogenous ligands.
Dreyer
C
C
Max-Planck-Institut für Entwicklungsbiologie, Tübingen, Federal Republic of Germany.
Krey
G
G
Keller
H
H
Givel
F
F
Helftenbein
G
G
Wahli
W
W
D042962:Acyl-CoA Oxidase; D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D004790:Enzyme Induction; D005227:Fatty Acids / Q000378:metabolism*; D005786:Gene Expression Regulation / Q000235:genetics; D008830:Microbodies / Q000378:metabolism*; D008969:Molecular Sequence Data; D010084:Oxidation-Reduction; D010088:Oxidoreductases / Q000096:biosynthesis* / Q000235:genetics; D012333:RNA, Messenger / Q000032:analysis; D011956:Receptors, Cell Surface / Q000096:biosynthesis* / Q000187:drug effects / Q000235:genetics*; D018160:Receptors, Cytoplasmic and Nuclear; D016415:Sequence Alignment; D014157:Transcription Factors / Q000096:biosynthesis / Q000235:genetics*; D014982:Xenopus laevis / Q000235:genetics*
D005227:Fatty Acids; D012333:RNA, Messenger; D011956:Receptors, Cell Surface; D018160:Receptors, Cytoplasmic and Nuclear; D014157:Transcription Factors; D010088:Oxidoreductases; D042962:Acyl-CoA Oxidase