title: Morphohistochemical characterization of suramin--induced chronic toxicity in rat kidney.
abstract: The effects of a chronic administration of suramin were evaluated on renal parenchyma of young rats. Animals were given suramin 18 mg/kg i.p. twice a week for two months, a treatment schedule equivalent to that used in cancer patients. At the end of the treatment, suramin concentrations in plasma and kidney were assayed and a morphohistochemical examination of renal parenchyma was carried out. Marked and widespread alterations were detected in both cortex and medulla and were associated with elevated tissue suramin levels exceeding 5 mg/g of tissue. The present data demonstrate that suramin induces a severe chronic renal damage in the rat, associated with high drug tissue levels.
authors.affiliation: Istituto di Anatomia Umana Normale, Università di Pisa, Italy.
authors.forename: P
authors.initials: P
authors.lastname: Soldani
authors.forename: R
authors.initials: R
authors.lastname: Danesi
authors.forename: M P
authors.initials: MP
authors.lastname: Ricciardi
authors.forename: A
authors.initials: A
authors.lastname: Pellegrini
authors.forename: G
authors.initials: G
authors.lastname: Natale
authors.forename: A
authors.initials: A
authors.lastname: Paparelli
mesh_terms: D000818:Animals; D004334:Drug Administration Schedule; D005260:Female; D007674:Kidney Diseases / Q000139:chemically induced* / Q000473:pathology; D051381:Rats; D017208:Rats, Wistar; D013498:Suramin / Q000008:administration & dosage / Q000633:toxicity*
chemical_list: D013498:Suramin