title: [Use of estrogens in skin patches in treatment of pre-menstrual syndrome].
abstract: A consequence of the diminishing the normal functioning of ovaries is progressing decrease in the levels of sex steroids leading to the clinical symptoms termed menopausal syndrome. This study aimed at evaluating the efficiency of Estraderm TTS-50 (Ciba-Geigy) in the treatment of this syndrome. The study involved 33 female patients, aged between 30 and 65 years. Estraderm in the form of patches containing 0.004 g of 17-estradiol was administered for 3 weeks every month, for 9 weeks. Kupperman's index, cytohormonal tests, and blood serum FSH and LH were tested before, during and after the treatment. A diminishing of the most common symptoms manifested by a statistically significant decrease in Kupperman's index and FSH, and LH levels with significant increase in serum estradiol was noted in 75% of patients following a 9-week treatment with Estraderm. Changes in the sex steroids levels led to a marked increase in the percentage of superficial cells, assessed with cytohormonal tests. Transdermal administration of estrogens in the form of Estraderm TTS-50 is the treatment of choice in the menopausal syndrome.
authors.affiliation: I Kliniki Połoznictwa i Ginekologii II Wydziału Lekarskiego AM w Warszawie.
authors.forename: Z
authors.initials: Z
authors.lastname: Liber
authors.forename: B
authors.initials: B
authors.lastname: Spiewankiewicz
authors.forename: J
authors.initials: J
authors.lastname: Stelmachów
mesh_terms: D000279:Administration, Cutaneous; D000328:Adult; D000368:Aged; D004958:Estradiol / Q000008:administration & dosage*; D015914:Estrogen Replacement Therapy; D005260:Female; D005640:Follicle Stimulating Hormone / Q000097:blood; D006801:Humans; D007986:Luteinizing Hormone / Q000097:blood; D008875:Middle Aged; D011293:Premenstrual Syndrome / Q000188:drug therapy* / Q000378:metabolism
chemical_list: D004958:Estradiol; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone
vernacular_title: Zastosowanie estrogenów w plastrach naskórnych w leczeniu zespołu klimakterycznego.