Progressive multifocal leukoencephalopathy and gliomas in a HIV-negative patient.
A case of progressive multifocal leukoencephalopathy (PML) is reported, detected at autopsy of a 30-year-old patient. The clinical picture was characterized by a progressive course of mental deterioration and ingravescent neurological symptoms. The patient was HIV-negative. He died of bronchopneumonia, after a clinical course of 13 months. Autopsy disclosed pulmonary tuberculosis with involvement of regional lymph nodes. In the brain, besides numerous PML-foci of varying age and structure, a pleomorphic astrocytoma was found in the white matter of the right parietal lobe. In the brain stem glial proliferation resembling diffuse gliomatosis was also present. In situ hybridization revealed Papova-virus (JCV) in oligoglial nuclei, but not in neoplastic astrocytes. This is the third report on the concomitant occurrence of PML and glioma in man.
Gullotta
F
F
Institut für Neuropathologie, Universität Münster, FRG.
Masini
T
T
Scarlato
G
G
Kuchelmeister
K
K
D000328:Adult; D001932:Brain Neoplasms / Q000150:complications / Q000473:pathology*; D005910:Glioma / Q000150:complications / Q000473:pathology*; D006679:HIV Seropositivity; D006801:Humans; D007968:Leukoencephalopathy, Progressive Multifocal / Q000150:complications / Q000473:pathology*; D008297:Male; D014391:Tuberculosis, Miliary / Q000150:complications