Rheumatoid factor and rheumatoid factor isotypes in loiasis with and without accompanying glomerulonephritis.
We have studied the distribution of rheumatoid factor isotypes amongst patients with loiasis with and without accompanying glomerulonephritis to determine the possible role of rheumatoid factor antiglobulins in this disease. Our findings indicate an increase in both immunoglobulin (Ig) G and IgM rheumatoid factor isotypes in patients with filariasis alone as well as in patients with accompanying glomerulonephritis. No association with IgA rheumatoid factor was found. The raised IgG and IgM rheumatoid factor levels did not correlate with corresponding IgG and IgM levels.
Adebajo
A O
AO
Rheumatology Research Unit, Addenbrooke's Hospital, Cambridge, UK.
Akinsola
A
A
Maizels
R M
RM
Cawston
T E
TE
Hazleman
B L
BL
D000293:Adolescent; D000328:Adult; D005921:Glomerulonephritis / Q000276:immunology* / Q000469:parasitology; D006801:Humans; D007070:Immunoglobulin A / Q000032:analysis; D007074:Immunoglobulin G / Q000032:analysis; D007075:Immunoglobulin M / Q000032:analysis; D008118:Loiasis / Q000276:immunology*; D008875:Middle Aged; D012217:Rheumatoid Factor / Q000032:analysis*
D007070:Immunoglobulin A; D007074:Immunoglobulin G; D007075:Immunoglobulin M; D012217:Rheumatoid Factor