title: [Increase in neuroendocrine secretion granules in submaxillary and parotid glands in patients with non-insulin dependent diabetes mellitus].
abstract: The amount of neuroendocrine granules in microgranular cells of salivary glands were investigated in necropsies of 20 non-insulin dependent diabetics (NIDDM) and in 20 non-diabetic subjects with Grimelius and Fontana-Masson stainings. Granules in serous acini, and intercalated ducts were observed in both groups; however, a significant higher number of granules and microgranular cells were observed in NIDDM subjects as compared with non-diabetics. Both parotid and submaxillary glands were significantly heavier in NIDDM than in the non-diabetic group. These granules may be related to immunoreactive glucagon which has been found in submaxillary glands of rodents and might play a role in the pathogenesis of NIDDM. Further investigations should be performed to clarify whether these cells are the site of glucagon synthesis and also clarify the pathogenesis of NIDDM.
authors.affiliation: División de Medicina, Hospital de Especialidades, Centro Médico Nacional Siglo XXI, IMSS.
authors.forename: S A
authors.initials: SA
authors.lastname: Islas Andrade
authors.forename: A C
authors.initials: AC
authors.lastname: Frati Munari
authors.forename: J
authors.initials: J
authors.lastname: González Angulo
authors.forename: P
authors.initials: P
authors.lastname: Iturralde
authors.forename: L M
authors.initials: LM
authors.lastname: Llanos Vega
mesh_terms: D000328:Adult; D000368:Aged; D002102:Cadaver; D003594:Cytoplasmic Granules / Q000473:pathology*; D003924:Diabetes Mellitus, Type 2 / Q000473:pathology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009490:Neurosecretory Systems / Q000473:pathology; D009929:Organ Size; D010306:Parotid Gland / Q000473:pathology*; D013363:Submandibular Gland / Q000473:pathology*
vernacular_title: Aumento de los gránulos de secreción neuroendócrina en glándulas submaxilares y parótidas en pacientes con diabetes mellitus no dependiente de insulina.