title: [Adverse effects of antidepressive agents in hospitalized geriatric patients].
abstract: The frequency, intensity and profile of adverse effects of antidepressants was studied in elderly patients. The series consisted of 102 patients with depression admitted to hospitals in Bratislava and Moscow. The adverse effects of amitriptyline (Amitriptylin Spofa) and maprotiline (Ludiomil Ciba-Geigy) were compared. The assessment done on days 0, 7, and 28 of treatment showed that xerostomia had the highest occurrence rate with both preparations studied. In patients treated with amitriptyline adverse effects were more severe and were recorded more frequently, requiring treatment withdrawal in 3 patients. The overall intensity of adverse effects was significantly higher with amitriptyline (p < 0.05). In the group of patients treated with amitriptyline the adverse effects were more marked in those with severe somatic pathology. The risk of amitriptyline treatment in elderly patients is being emphasized along with the need for monitoring and correcting adverse effects of the treatment. Although maprotiline exhibited a lower occurrence rate of adverse effects, cardiac functions should be regularly checked in patients with preexisting cardiac pathology. (Tab. 2, Fig. 3, Ref. 6.).
authors.affiliation: Psychiatrická klinika LFUK a FN v Bratislave, CSFR.
authors.forename: V
authors.initials: V
authors.lastname: Korínková
authors.forename: E
authors.initials: E
authors.lastname: Kolibás
authors.forename: M
authors.initials: M
authors.lastname: Králová
authors.forename: V
authors.initials: V
authors.lastname: Novotný
authors.forename: V A
authors.initials: VA
authors.lastname: Konceoj
authors.forename: A N
authors.initials: AN
authors.lastname: Pjatnickij
authors.forename: M P
authors.initials: MP
authors.lastname: Andrusenkova
mesh_terms: D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D000639:Amitriptyline / Q000009:adverse effects*; D006760:Hospitalization; D006801:Humans; D008376:Maprotiline / Q000009:adverse effects*; D008875:Middle Aged
chemical_list: D000639:Amitriptyline; D008376:Maprotiline
vernacular_title: Neziadúce úcinky antidepresív u hospitalizovaných gerontopsychiatrických pacientov.