[Effects of various recombinant human hematopoietic growth factors on proliferation of blast cells in acute myeloid leukemia in vitro].
In vitro proliferative response of the blast cells from 21 AML patients to hematopoietic growth factors (IL-3, GM-CSF, G-CSF and MCSF) was investigated. Proliferation of AML cells in the majority of cases was induced or promoted by one or more CSFs, among which the stimulation of IL-3 was the most effective. Spontaneous proliferation of the blast cells was also observed in half of the cases and could be inhibited as well as promoted by some CSFs. It is suggested that in vitro proliferation of AML cells varies from patient to patient and that CSF plays important roles in leukemogenesis.
Wang
C
C
Institute of Hematology, Tongji Medical University, Wuhan.
Wang
B M
BM
Li
C Y
CY
D000293:Adolescent; D000328:Adult; D002455:Cell Division / Q000187:drug effects; D002648:Child; D002675:Child, Preschool; D003115:Colony-Stimulating Factors / Q000494:pharmacology*; D005260:Female; D006801:Humans; D007377:Interleukin-3 / Q000494:pharmacology; D007948:Leukemia, Monocytic, Acute / Q000473:pathology; D015470:Leukemia, Myeloid, Acute / Q000473:pathology*; D015479:Leukemia, Myelomonocytic, Acute / Q000473:pathology; D008297:Male; D008875:Middle Aged; D011994:Recombinant Proteins / Q000494:pharmacology; D014407:Tumor Cells, Cultured / Q000187:drug effects
D003115:Colony-Stimulating Factors; D007377:Interleukin-3; D011994:Recombinant Proteins