The putative melanoma tumor-suppressor gene on human chromosome 6q.
The tumorigenicity of malignant melanoma cells may be suppressed experimentally by the introduction into these cells of human chromosome 6 or mouse chromosome 4. These chromosomes share a homologous region, contained in human chromosome 6q12-21. Abnormalities of this human chromosomal region have been found frequently not only in cutaneous and uveal malignant melanomas, but also in a range of other tumors. In all these, mutations of tumor-suppressor genes on human chromosome 6q may be involved. Identification of this putative tumor-suppressor gene may give new insights into the biology of malignant melanomas, and could pave the way for new treatment for such tumors, based upon the tumor-suppressor protein which this gene is likely to encode.
Copeman
M C
MC
Department of Oncology, Royal Alexandra Hospital for Children, Camperdown, NSW.
D000818:Animals; D002869:Chromosome Aberrations / Q000235:genetics; D025063:Chromosome Disorders; D002874:Chromosome Mapping; D002896:Chromosomes, Human, Pair 6; D005134:Eye Neoplasms / Q000235:genetics; D016147:Genes, Tumor Suppressor / Q000235:genetics*; D006801:Humans; D008545:Melanoma / Q000235:genetics*; D051379:Mice; D012175:Retinoblastoma / Q000235:genetics; D017385:Sequence Homology; D012878:Skin Neoplasms / Q000235:genetics; D014604:Uveal Neoplasms / Q000235:genetics