Brain pathology in 6 fatal cases of post-transfusion hypertension, convulsion and cerebral hemorrhage syndrome.
Six fatal cases of post-transfusion hypertension, convulsions and cerebral hemorrhage syndrome were found in a series of 76 autopsies of thalassemic patients. Five of these cases were hypertensive. At autopsy the brains were all markedly edematous and congested. Visible cerebral hemorrhages were found in 3 patients. Microscopically all cases showed small focal or perivascular hemorrhages and 1 patient had extensive arterial type hemorrhage. Microdissecting aneurysms characteristic of hypertensive cerebral hemorrhage were found in two. No underlying vascular disease was found in these 6 patients. A correlation was attempted between possible causes of post-transfusion hypertension and convulsions and anatomical findings.
Sonakul
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Department of Pathology, Faculty of Medicine, Siriraj Hospital, Mahidol University, Bangkok, Thailand.
Fucharoen
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S
D000293:Adolescent; D001794:Blood Pressure; D001929:Brain Edema / Q000209:etiology / Q000473:pathology*; D002543:Cerebral Hemorrhage / Q000209:etiology / Q000473:pathology*; D002648:Child; D002675:Child, Preschool; D005260:Female; D006446:Hemoglobin E; D006453:Hemoglobinopathies / Q000150:complications / Q000601:surgery / Q000628:therapy*; D006801:Humans; D006973:Hypertension / Q000209:etiology / Q000473:pathology*; D008297:Male; D009929:Organ Size; D011183:Postoperative Complications / Q000209:etiology / Q000473:pathology*; D012640:Seizures / Q000209:etiology / Q000473:pathology*; D013156:Splenectomy; D065227:Transfusion Reaction; D017086:beta-Thalassemia / Q000150:complications / Q000601:surgery / Q000628:therapy*
D006446:Hemoglobin E