[Changes of protein turnover in perioperative patients and effect of recombinant human growth hormone].
15N-Glycine constant infusion method was applied to study the changes of protein metabolism after major abdominal operation and the influence of recombinant human growth hormone (GH). Our results showed: (1) under the support of total parenteral nutrition (30 cal/kg/d and 1.25 g protein/kg/d), the protein turnover rate (Q), synthetic rate (S) and catabolic rate (C) all increased significantly (P < 0.05) with an outstriping increase of C over S on postoperative day 3 in comparison with that on preoperative day 3; (2) with the support of hypocaloric parenteral nutrition (20 cal/kg/d and 1.00 g protein/kg/d), Q, C values also increased significantly (P < 0.05) comparing with that of the control group on post operative day 7 in patients treated with one week GH (0.15 iu/kg/d), but S value increased more significantly (P < 0.01), which indicated that the postoperative use of TPN plus GH is much better than giving TPN alone.
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Peking Union Medical College Hospital, Beijing.
D000328:Adult; D000368:Aged; D003082:Colectomy; D003093:Colitis, Ulcerative / Q000601:surgery; D005743:Gastrectomy; D013006:Growth Hormone / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010289:Parenteral Nutrition, Total; D011506:Proteins / Q000378:metabolism*; D011994:Recombinant Proteins / Q000627:therapeutic use*; D013274:Stomach Neoplasms / Q000601:surgery; D013276:Stomach Ulcer / Q000601:surgery
D011506:Proteins; D011994:Recombinant Proteins; D013006:Growth Hormone