A case of skin hyperpigmentation due to alpha-MSH hypersecretion.
A case is presented of generalized skin hyperpigmentation due to alpha-MSH hypersecretion from the pituitary that was most marked in the light-exposed areas. The patient also had secondary adrenal dysfunction, peripheral lymphadenopathy, streptococcal glomerulonephritis and malabsorption. Analysis of this patient's alpha-MSH using high-pressure liquid chromatography (HPLC) showed a novel acetylation profile compared to normal individuals and to patients with Cushing's disease and Nelson's syndrome. Glucocorticoid replacement therapy resulted in suppression of alpha-MSH hypersecretion and complete resolution of the illness.
Pears
J S
JS
Department of Medicine, University of Dundee Medical School, Ninewells Hospital, U.K.
Jung
R T
RT
Bartlett
W
W
Browning
M C
MC
Kenicer
K
K
Thody
A J
AJ
D002851:Chromatography, High Pressure Liquid; D006801:Humans; D006854:Hydrocortisone / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged; D010859:Pigmentation Disorders / Q000097:blood / Q000188:drug therapy / Q000209:etiology*; D010902:Pituitary Gland / Q000378:metabolism; D000521:alpha-MSH / Q000097:blood / Q000378:metabolism*
D000521:alpha-MSH; D006854:Hydrocortisone