Efficacy of ivermectin against Parastrongylus malaysiensis infection in rats.
The efficacy of ivermectin on experimental infections of P. malaysiensis in rats was determined. Ivermectin was 99.4% and 97.9% effective at a dosage of 400 meg and 800 meg respectively at seven days post-infection. The same two dosages of ivermectin when given at 14 days post infection had an efficacy of 100%. However, as an adulticide it had only 40.7% efficacy. Ivermectin may therefore be useful for the treatment of parastrongyliasis due to the larval stages of the worm which can cause significant pathology in man and animals.
Ambu
S
S
Institute for Medical Research, Kuala Lumpur, Malaysia.
Mak
J W
JW
Ng
C S
CS
D000801:Angiostrongylus / Q000187:drug effects*; D000818:Animals; D004305:Dose-Response Relationship, Drug; D005260:Female; D007559:Ivermectin / Q000627:therapeutic use*; D051381:Rats; D017207:Rats, Sprague-Dawley; D017206:Strongylida Infections / Q000188:drug therapy*
D007559:Ivermectin