[Severe form of neonatal hemolytic disease by anti-Vel allo-immunization].
BACKGROUND
Routine detection of maternal sensitization during pregnancy sometimes reveals alloimmunization by exceptional antigens.


METHODS
A first pregnancy was complicated by a severe post-partum anemia in the mother, that required a blood transfusion. Irregular agglutinins were detected during the first trimester of a second pregnancy, for which the father was different from the first. The specific antibody was not identified at that time. The newborn, born at a gestational age of 39 weeks, developed severe jaundice at 3 hours of life, with hemolytic disease, anemia and hepatomegaly. Therapy included two transfusions of packed, washed red cells obtained from the mother on days 7 and 25. Immunologic tests showed that the hemolytic disease of this newborn was due to an anti-Vel alloimmunization.


CONCLUSIONS
Antibodies detected during the pregnancy must be identified in order to manage properly any perinatal problems due to rare antibodies.
Le Masne
A
A
Service de Médecine Néonatale, Centre Hospitalier Regional Universitaire de Lille.
Vachée
A
A
Horbey
C
C
Mannessier
L
L
Gruca
L
L
Rouland
V
V
Lequien
P
P
D000743:Anemia, Hemolytic / Q000209:etiology*; D000751:Anemia, Neonatal / Q000209:etiology*; D001789:Blood Group Antigens / Q000276:immunology*; D001787:Blood Group Incompatibility / Q000150:complications; D004899:Erythroblastosis, Fetal / Q000209:etiology / Q000276:immunology; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D007518:Isoantibodies / Q000032:analysis; D011247:Pregnancy; D012203:Rh Isoimmunization / Q000150:complications*; D065227:Transfusion Reaction
D001789:Blood Group Antigens; D007518:Isoantibodies
Forme sévère de maladie hémolytique néonatale par allo-immunisation anti-Vel.