Carbamazepine-induced systemic lupus erythematosus-like disease.
A 14-year-old female developed systemic lupus erythematosus (SLE)-like symptoms, rash, fever, leukopenia and positive anti-nuclear antibody (ANA) two weeks after administration of carbamazepine (CBZ; Tegretol) used against benign Rolandic epilepsy. Clinical symptoms and leukopenia normalized after discontinuation of CBZ and administration of prednisolone at 40 mg. The cases of CBZ-induced SLE reported in the literature were reviewed.
Kanno
T
T
Department of Internal Medicine II, Fukushima Medical College, Japan.
Miyata
M
M
Kazuta
Y
Y
Sato
Y
Y
Nishimaki
T
T
Kasukawa
R
R
D000293:Adolescent; D002220:Carbamazepine / Q000009:adverse effects*; D004827:Epilepsy / Q000188:drug therapy; D005260:Female; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000139:chemically induced* / Q000175:diagnosis / Q000188:drug therapy; D011239:Prednisolone / Q000627:therapeutic use
D002220:Carbamazepine; D011239:Prednisolone