Epidermal expression of the calcium binding surface antigen 27E10 in inflammatory skin diseases.
The expression of the heterodimeric complex of the calcium-binding proteins MRP-8 and MRP-14 was investigated in various inflammatory dermatoses using immunohistochemical staining with the monoclonal antibody 27E10. In addition to the inflammatory infiltrate, a positive staining was repeatedly found in the involved epidermis from patients with lichen planus, lupus erythematosus and psoriasis vulgaris, but not in normal skin epidermis and/or in epidermis from leucocytoclastic vasculitis patients. The keratinocytic expression of the 27E10 antigen was dissimilar to that of the MHC class-II molecules and the adhesion molecule ICAM-1. These data indicate that the 27E10 antigen is a distinct activation marker of inflammatory keratinocytes and may have proinflammatory properties.
Kunz
M
M
Department of Dermatology, University of Münster, Federal Republic of Germany.
Roth
J
J
Sorg
C
C
Kolde
G
G
D000954:Antigens, Surface / Q000032:analysis* / Q000276:immunology; D002118:Calcium / Q000378:metabolism*; D003872:Dermatitis / Q000276:immunology*; D004817:Epidermis / Q000276:immunology*; D006801:Humans; D007150:Immunohistochemistry; D015603:Keratinocytes / Q000276:immunology*; D008010:Lichen Planus / Q000276:immunology; D008179:Lupus Erythematosus, Discoid / Q000276:immunology; D011565:Psoriasis / Q000276:immunology; D012016:Reference Values; D014657:Vasculitis / Q000276:immunology
D000954:Antigens, Surface; D002118:Calcium