[Tumor necrosis factor and interleukin 6 in hepatitis C virus infection].
Tumor necrosis factor (TNF) was determined with ELISA in 72 patients with hepatitis C and hepatitis B virus infections. Interleukin 6 (IL-6) was determined at the same time. TNF and IL-6 were significantly increased in patients with hepatitis C virus infections when compared with normal subjects and hepatitis B patients. There was a significant positive correlation between TNF and IL-6. It is suggested that increased TNF and IL-6 may play an important role in pathogenesis of hepatitis C virus infection.
Ren
H
H
Institute of Viral Hepatitis, Chongqing Medical University.
Zheng
D F
DF
Jia
X P
XP
D000328:Adult; D000911:Antibodies, Monoclonal; D004797:Enzyme-Linked Immunosorbent Assay; D006509:Hepatitis B / Q000097:blood; D006526:Hepatitis C / Q000097:blood* / Q000209:etiology; D006521:Hepatitis, Chronic / Q000097:blood; D006801:Humans; D015850:Interleukin-6 / Q000097:blood*; D015163:Superinfection / Q000097:blood; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism*
D000911:Antibodies, Monoclonal; D015850:Interleukin-6; D014409:Tumor Necrosis Factor-alpha