title: [Factors influencing carboxyhemoglobin kinetics in inhalation lung injury].
abstract: Anesthetized dogs were ventilated with 1% carbon monoxide (CO) in air for 10 minutes to produce CO poisoning and then with room air (n = 5) or pure oxygen (n = 5) for 3 hours as control. Acute lung injury was produced by intratracheal injection of 0.1 N HCl (2 ml/kg) 30 minutes before CO poisoning in another 10 experimental dogs. Arterial blood gas and carboxyhemoglobin (COHb) were monitored before and after CO poisoning. Pharmacokinetic analysis was used to find the half-time of COHb elimination (T 1/2 beta). Pulmonary shunt was measured before CO poisoning in the injured dogs. Half-time of COHb elimination was prolonged in the injured dogs resuscitated with air as compared with dogs in the control group (275% +/- 28 vs. 203 +/- 24 min., P < 0.05); Oxygen accelerated COHb excretion in both injured and control animals. No significant correlation was found between T 1/2 beta and Qs/Qt in the injured dogs ventilated with air or oxygen. A negative linear relationship was found between T 1/2 beta of COHb elimination and the pre-CO-poisoning PaO2 (r = -0.98, P < 0.005) in the injured dogs treated with oxygen. The data suggest that hypoxemia may represent the underlying mechanism of altered COHb kinetics in acute inhalation lung injury.
authors.affiliation: First Affiliated Hospital of Nanjing Medical College.
authors.forename: W X
authors.initials: WX
authors.lastname: Wu
mesh_terms: D000818:Animals; D001784:Blood Gas Analysis; D002249:Carbon Monoxide Poisoning / Q000097:blood* / Q000628:therapy; D002263:Carboxyhemoglobin / Q000378:metabolism*; D004285:Dogs; D006851:Hydrochloric Acid; D008171:Lung Diseases / Q000097:blood* / Q000139:chemically induced / Q000628:therapy; D008657:Metabolic Clearance Rate; D012151:Resuscitation
chemical_list: D002263:Carboxyhemoglobin; D006851:Hydrochloric Acid