Patterns of ploidy in renal cell carcinoma.
In a prospective study the patterns of ploidy in 119 kidneys from patients with renal cell carcinoma were analyzed by flow cytometry. A rate of DNA aneuploidy of 53% was observed in the investigated tumors. However, in 4% of the kidneys aneuploid cell distributions were also proven in macroscopically intact tissue far away from the tumor. Although we do not know at present, if these were benign, premalignant or malignant cell alterations, this observation should be considered for decisions regarding conservative renal surgery.
Leyh
H
H
Department of Urology, Technische Universität München, Klinikum rechts der Isar, Germany.
Lehmer
A
A
Hartung
R
R
D000782:Aneuploidy; D002292:Carcinoma, Renal Cell / Q000235:genetics*; D004247:DNA / Q000235:genetics; D004171:Diploidy; D005434:Flow Cytometry; D006801:Humans; D007680:Kidney Neoplasms / Q000235:genetics*; D011123:Polyploidy
D004247:DNA