title: Distribution of hyaluronan in the mouse endometrium during the periimplantation period of pregnancy.
abstract: The tissue distribution of stromal hyaluronan (HA) in the periimplantation mouse uterus was studied histochemically using a biotin-labelled HA-binding complex from cartilage proteoglycan. HA is present around proliferating stromal cells in both the pregnant and pseudopregnant mouse uterus prior to their differentiation into the decidualized phenotype. Decidualization is accompanied by clearance of HA from the extracellular matrix (ECM). This clearing is part of an intrinsic developmental program of the differentiating deciduum. A specific embryonic signal from the implanting conceptus is not required for this phenomenon to occur, since a similar response could be induced in deciduoma produced by artificial stimulation of a receptive uterus. Clearing of HA from the antimesometrial stroma is consistent with the hypothesis that the HA-negative decidual cell may be involved in restricting the invasion of trophoblast cells during embryo implantation. Retention of HA within angiogenic regions of the decidua basalis implies a functional role for this molecule in placental vascularization.
authors.affiliation: Department of Pathology, Tufts University Schools of Medicine and Veterinary Medicine, Boston, MA 02111.
authors.forename: J J
authors.initials: JJ
authors.lastname: Brown
authors.forename: V E
authors.initials: VE
authors.lastname: Papaioannou
mesh_terms: D000818:Animals; D003656:Decidua / Q000737:chemistry* / Q000254:growth & development; D010064:Embryo Implantation; D004717:Endometrium / Q000737:chemistry*; D005260:Female; D006820:Hyaluronic Acid / Q000032:analysis*; D051379:Mice; D011555:Pseudopregnancy / Q000378:metabolism*
chemical_list: D006820:Hyaluronic Acid