[The neurotropic properties of new 4,4-di-substituted derivatives of 1-methylpiperidine].
Experiments on small laboratory animals were made to study local anesthetic, antinociceptive and antihypoxic properties of 6 new derivatives of 1-methylpiperidine. A substance coded phi AB-8 (1-methyl-4-vinylethynil-4-benzoyl hydroxypiperidine hydrochloride) was found to exert a pronounced local anesthetic and an antihypoxic actions.
Kurbat
N M
NM
Korshak
T A
TA
Stankevich
P B
PB
Kozlovskiĭ
V I
VI
D000208:Acute Disease; D000779:Anesthetics, Local / Q000494:pharmacology* / Q000627:therapeutic use / Q000633:toxicity; D000818:Animals; D004353:Drug Evaluation, Preclinical; D004347:Drug Interactions; D006168:Guinea Pigs; D000860:Hypoxia / Q000188:drug therapy; D007928:Lethal Dose 50; D051379:Mice; D009043:Motor Activity / Q000187:drug effects; D009420:Nervous System / Q000187:drug effects*; D010880:Piperidines / Q000494:pharmacology* / Q000627:therapeutic use / Q000633:toxicity; D011898:Ranidae; D051381:Rats; D013329:Structure-Activity Relationship
D000779:Anesthetics, Local; D010880:Piperidines
Neĭrotropnye svoĭstva novykh 4,4-di-zameshchennykh proizvodnykh 1-metilpiperidina.