Prenatal detection of multiple copies of a familial supernumerary marker chromosome.
Direct preparations and long-term cultures from a chorion villus biopsy, taken because of a known maternal additional marker chromosome, showed a 48,XX,+mar,+mar karyotype in all cells examined. The same karyotype was revealed in a subsequent amniotic fluid sample and in cord blood at delivery. Detailed examination of the child at delivery and at 1 year of age showed no evidence of phenotypic abnormality or developmental problems.
Wolstenholme
J
J
Department of Human Genetics, University of Newcastle upon Tyne, U.K.
Brummitt
J A
JA
English
C J
CJ
Goodship
J A
JA
D000328:Adult; D015193:Chorionic Villi Sampling; D002869:Chromosome Aberrations; D005260:Female; D005312:Fetal Blood / Q000166:cytology; D005819:Genetic Markers; D006801:Humans; D011247:Pregnancy; D011261:Pregnancy Trimester, First
D005819:Genetic Markers