title: Scoparic acid A, a beta-glucuronidase inhibitor from Scoparia dulcis.
abstract: The 70% EtOH extract of Scoparia dulcis showed inhibitory activity against beta-glucuronidase from bovine liver. Bioassay-directed fractionation of the active extract led to the isolation of three labdane-type diterpene acids, scoparic acid A [1] [6-benzoyl-12-hydroxy-labda-8(17), 13-dien-18-oic acid], scoparic acid B [2] [6-benzoyl-14,15-dinor-13-oxo-8(17)-labden-18-oic acid], and scoparic acid C [3] [6-benzoyl-15-nor-14-oxo-8(17)-labden-18-oic acid], the structures of which were established by spectral means, including X-ray analysis. Scoparic acid A was found to be a potent beta-glucuronidase inhibitor.
authors.affiliation: Faculty of Pharmaceutical Sciences, Toyama Medical and Pharmaceutical University, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Hayashi
authors.forename: M
authors.initials: M
authors.lastname: Kawasaki
authors.forename: K
authors.initials: K
authors.lastname: Okamura
authors.forename: Y
authors.initials: Y
authors.lastname: Tamada
authors.forename: N
authors.initials: N
authors.lastname: Morita
authors.forename: Y
authors.initials: Y
authors.lastname: Tezuka
authors.forename: T
authors.initials: T
authors.lastname: Kikuchi
authors.forename: Y
authors.initials: Y
authors.lastname: Miwa
authors.forename: T
authors.initials: T
authors.lastname: Taga
mesh_terms: D000107:Acetylation; D003460:Crystallization; D004224:Diterpenes / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D005966:Glucuronidase / Q000037:antagonists & inhibitors*; D009682:Magnetic Resonance Spectroscopy; D008745:Methylation; D008968:Molecular Conformation; D010239:Paraguay; D010946:Plants, Medicinal / Q000737:chemistry*; D014961:X-Ray Diffraction
chemical_list: D004224:Diterpenes; C055030:scoparic acid A; D005966:Glucuronidase