Tissue-specific production of the third component of complement(C3) by vitamin D in bone.
The third component of complement (C3) is a protein produced by osteoblastic cells in response to 1 alpha,25(OH)2D3. The bone C3 appears to be involved in differentiation of bone marrow cells into osteoclasts in concert with other vitamin D-dependent factors. Further studies are needed to understand the precise role of C3 in bone.
Abe
E
E
Department of Biochemistry, School of Dentistry, Showa University, Tokyo, Japan.
Jin
C H
CH
Hong
M H
MH
Sato
T
T
Shinki
T
T
Suda
T
T
D000818:Animals; D001842:Bone and Bones / Q000166:cytology / Q000187:drug effects* / Q000378:metabolism; D002117:Calcitriol / Q000494:pharmacology*; D003176:Complement C3 / Q000096:biosynthesis* / Q000502:physiology; D008099:Liver / Q000166:cytology / Q000187:drug effects / Q000378:metabolism; D008970:Molecular Weight; D010006:Osteoblasts / Q000187:drug effects / Q000378:metabolism; D011506:Proteins / Q000032:analysis; D012680:Sensitivity and Specificity
D003176:Complement C3; D011506:Proteins; D002117:Calcitriol