[The antiviral action of a modified bacterial ribonuclease].
The antiviral activity of a bacterial ribonuclease conjugate with chitosane of Kamchatka crab (in a form of water soluble chito-oligosaccharides) has been studied. The conjugate inhibitory activity for A and B viruses as well as to Sindbis arbovirus in tissue cultures is shown. The preparation efficiency at intramuscular and intranasal administration was observed at experimental influenza infection of white mice.
Indulen
M K
MK
Zamiatina
N A
NA
Varlamov
V P
VP
Il'ina
A V
AV
D000818:Animals; D000998:Antiviral Agents / Q000494:pharmacology* / Q000627:therapeutic use; D001407:Bacillus / Q000201:enzymology; D003386:Brachyura / Q000201:enzymology; D002686:Chitin / Q000031:analogs & derivatives / Q000494:pharmacology / Q000627:therapeutic use; D048271:Chitosan; D004338:Drug Combinations; D004353:Drug Evaluation, Preclinical; D009980:Influenza A virus / Q000187:drug effects; D009981:Influenza B virus / Q000187:drug effects; D051379:Mice; D009976:Orthomyxoviridae Infections / Q000188:drug therapy; D012260:Ribonucleases / Q000494:pharmacology* / Q000627:therapeutic use; D012845:Sindbis Virus / Q000187:drug effects
D000998:Antiviral Agents; D004338:Drug Combinations; D002686:Chitin; D048271:Chitosan; D012260:Ribonucleases
Izuchenie antivirusnogo deĭstviia modifitsirovannoĭ bakterial'noĭ ribonukleazy.