[Effects of zinc deficiency and vitamin D deficiency on bone calcification and development of rats].
Zinc deficiency rat model was made by feeding zinc deficiency diet. The level of bone calcium of the zinc deficiency rats was significantly lower than that of the control rats. Their bone cortex was thinner and bone density decreased. The counts of their cartilage cells and hypertrophic cells of epiphyseal plate were less frequent, and the diameter of their hypertrophic cells was smaller than that of the controls. It suggested that zinc deficiency caused defective bone calcification which was similar to that in vitamin D deficiency. Zinc deficiency seemed to hinder the linear growth of long bone and might be the cause of dwarf.
Xu
B
B
Department of Pediatrics, Second Affiliated Hospital.
Zheng
D
D
Qian
Y
Y
Wu
K
K
D000818:Animals; D015519:Bone Density; D001846:Bone Development; D001842:Bone and Bones / Q000378:metabolism / Q000473:pathology; D002113:Calcification, Physiologic; D002118:Calcium / Q000378:metabolism; D005260:Female; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D014808:Vitamin D Deficiency / Q000503:physiopathology*; D015032:Zinc / Q000172:deficiency*
D015032:Zinc; D002118:Calcium