[Effect of subinhibitory concentrations of antibiotics on catalase activity of plague microbes].
It was shown that the presence of subinhibitory concentrations of ampicillin, cefotaxime or gentamicin in the cultivation medium had a marked inhibitory effect on the catalase activity of plague microbe. The effect depended on the characteristic features of plague microbe strains and the incubation temperature. When the cells of a virulent strain of the plague microbe Y. pestis 1300 were cultivated at a temperature of 37 degrees C on a medium containing the subinhibitory concentrations of ampicillin or cefotaxime, the pathogen virulence for albino mice significantly decreased.
Ryzhkova
V V
VV
Blagorodova
N S
NS
Mikhalevich
R V
RV
Pavlovich
N V
NV
D000667:Ampicillin / Q000494:pharmacology*; D002374:Catalase / Q000187:drug effects*; D002439:Cefotaxime / Q000494:pharmacology*; D005839:Gentamicins / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests; D013696:Temperature; D015010:Yersinia pestis / Q000187:drug effects* / Q000201:enzymology / Q000472:pathogenicity
D005839:Gentamicins; D000667:Ampicillin; D002374:Catalase; D002439:Cefotaxime
Vliianie subingibiruiushchikh kontsentratsii antibiotikov na katalaznuiu aktivnost' chumnogo mikroba.