[Preliminary study of changes in plasma prostaglandin E1 in rats with experimental "schizophrenia"].
We referred to Borison's method of making the model schizophrenia. Rats were injected d-amphetamine intraperitoneally once a day so that the schizophrenia models were established within four weeks. After five weeks, rats with schizophrenia were treated with chlorpromazine. Contents of plasma prostaglandin E1(PGE1) in rats were determined before and after treatment respectively. This study demonstrated that contents of plasma PGE1 in rats receiving amphetamine for four weeks were higher than those in control animals (P < 0.05). At this time, male rats' stereotypy scores were 3.5 and female stereotypy scores 5. But contents of plasma PGE1 in rats with schizophrenia approached those in control animals with giving amphetamine once a day continuously. Contents of plasma PGE1 decreased in rats with schizophrenia receiving chlorpromazine.
Kong
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Department of Biochemistry, Hebei Medical College, Shijiazhuang.
D000527:Alprostadil / Q000097:blood*; D000818:Animals; D002746:Chlorpromazine / Q000627:therapeutic use*; D003913:Dextroamphetamine; D004195:Disease Models, Animal; D005260:Female; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D012559:Schizophrenia / Q000097:blood* / Q000139:chemically induced / Q000188:drug therapy
D000527:Alprostadil; D003913:Dextroamphetamine; D002746:Chlorpromazine