[A flow cytometric study of the effect of chemotherapy on the lymphocyte population composition in chronic lympholeukemia].
Results are described of a study of the population and subpopulation composition of lymphocytes in the course of use monochemotherapy (MTS) and polychemotherapy (PCT) in 60 patients with the tumorous form of B-cell chronic lympholeucosis using flow cytometric analysis. It was shown that cytostatic treatment in this form of hemoblastosis results in a reduction of the absolute number of B-lymphocytes due to reduction of general hemocytosis while the relative content of B-cells remained unchanged in MCT and is increased in PCT. A prolonged scheme of PCT is recommended for clinical use that possesses a distinct antitumour effect as compared with MCT and producing a significantly smaller immunosuppressive effect on the T-cell immune system that other schemes of cytostatic therapy.
Dudko
E T
ET
Tishchenko
L M
LM
Krivozubov
V B
VB
D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D005260:Female; D005434:Flow Cytometry; D006801:Humans; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000188:drug therapy / Q000276:immunology*; D007958:Leukocyte Count / Q000187:drug effects; D016131:Lymphocyte Subsets / Q000187:drug effects* / Q000276:immunology; D008297:Male; D008875:Middle Aged
Protochno-tsitometricheskoe issledovanie vliianiia khimioterapii na populiatsionnyĭ sostav limfotsitov pri khronicheskom limfoleĭkoze.