title: The perception of teratogenic risk of cocaine.
abstract: While there has been a substantial increase in recreational use of cocaine by young adults, conclusive evidence for cocaine teratogenicity in humans is lacking, and even those believing the drug is teratogenic agree that the rates are quite small. While counseling pregnant women on their teratogenic risk, it was our impression that there is an unrealistically high perception of reproductive risk of cocaine. We wished to quantify the perception of teratogenic risk of cocaine by the public, physicians, and by pregnant women who were counseled following gestational exposure to the drug. Women taking cocaine during the first trimester of pregnancy (n = 54), controls with post secondary education (n = 30), and physicians (n = 30) were asked, using a visual analogue scale, to quantify the teratogenic risk of cocaine and the tendency to terminate/continue the pregnancy after first trimester exposure; in the case of the "public" and physicians this was a hypothetical question. Both physicians and the controls perceived cocaine to be teratogenic (13.4 +/- 11% risk of major malformations by physicians, and 56.5 +/- 22.8% by the "public"). The controls believed cocaine to be as hazardous as thalidomide (57.2 +/- 25.6% risk for thalidomide). Asked whether they would wish to terminate such pregnancy in their family, most physicians (56%) and the controls (70%) had a greater than 50% tendency to terminate.(ABSTRACT TRUNCATED AT 250 WORDS)
authors.affiliation: Department of Pediatrics, Hospital for Sick Children, Toronto, Ontario.
authors.forename: G
authors.initials: G
authors.lastname: Koren
authors.forename: D
authors.initials: D
authors.lastname: Gladstone
authors.forename: C
authors.initials: C
authors.lastname: Robeson
authors.forename: I
authors.initials: I
authors.lastname: Robieux
mesh_terms: D000014:Abnormalities, Drug-Induced / Q000523:psychology*; D000032:Abortion, Therapeutic; D003042:Cocaine / Q000633:toxicity*; D003376:Counseling; D004501:Education, Medical; D005260:Female; D006801:Humans; D010465:Perception; D011247:Pregnancy; D011261:Pregnancy Trimester, First / Q000187:drug effects / Q000523:psychology*; D012307:Risk Factors; D013792:Thalidomide / Q000633:toxicity
chemical_list: D013792:Thalidomide; D003042:Cocaine