title: [Agranulocytosis--a complication of the chemotherapy of echinococcosis with mebendazole].
abstract: Only two of the 75 patients with echinococcosis, treated with mebendazole in a dose of 50 mg/kg b. m. for 30 days (single course) and administered from 1 to 13 courses with intervals of 1 to 3 months, developed agranulocytosis eventuating in death in one female patient. Analysis of blood levels of mebendazole and its metabolites permits a hypothesis that high concentrations thereof may have a toxic effect on the bone marrow, inducing its hypoplasia, in subjects sensitive to these substances.
authors.forename: A M
authors.initials: AM
authors.lastname: Shcherbakov
authors.forename: T L
authors.initials: TL
authors.lastname: Kozlova
authors.forename: N K
authors.initials: NK
authors.lastname: Bebris
mesh_terms: D000208:Acute Disease; D000328:Adult; D000380:Agranulocytosis / Q000097:blood / Q000139:chemically induced* / Q000473:pathology; D004444:Echinococcosis, Hepatic / Q000097:blood / Q000150:complications* / Q000188:drug therapy / Q000473:pathology; D004445:Echinococcosis, Pulmonary / Q000097:blood / Q000150:complications* / Q000188:drug therapy / Q000473:pathology; D005260:Female; D006801:Humans; D008463:Mebendazole / Q000008:administration & dosage / Q000009:adverse effects*; D008875:Middle Aged; D013997:Time Factors
chemical_list: D008463:Mebendazole
vernacular_title: Agranulotsitoz--oslozhnenie khimioterapii ékhinokokkozov mebendazolom.