[The action of specific antimembrane antibodies on the tonic tension and contractile phases of the heart muscle in rats].
Antibodies specific to rat myocardial sarcolemma inhibit phasic contractions and promote an increase in tonic tension of isolated strips of the cardiac muscle in rat. These results indicate that antibodies induce accumulation of intracellular free Ca2+. Analysis of the authors' data and those from literature suggests that specific antibodies inhibit Na(+)-K(+)-pump activity of the cardiac muscle in rat. This conclusion is confirmed by analogy of effects of ouabaine, the well-known inhibitor of Na(+)-K(+)-pump, on the rat cardiac muscle.
Bidzilia
Iu P
IuP
Ianchiĭ
R I
RI
Lushnikova
I V
IV
D000818:Animals; D000906:Antibodies / Q000494:pharmacology*; D000918:Antibody Specificity / Q000276:immunology*; D002462:Cell Membrane / Q000276:immunology; D066298:In Vitro Techniques; D009129:Muscle Tonus / Q000187:drug effects / Q000276:immunology*; D009200:Myocardial Contraction / Q000187:drug effects / Q000276:immunology*; D009206:Myocardium / Q000276:immunology*; D010042:Ouabain / Q000494:pharmacology; D010210:Papillary Muscles / Q000187:drug effects / Q000276:immunology; D011817:Rabbits; D051381:Rats; D013328:Strophanthins / Q000494:pharmacology
D000906:Antibodies; D013328:Strophanthins; D010042:Ouabain; C029082:strophanthin K
Diia spetsyfichnykh antymembrannykh antytil na tonichnu napruhu ta fazni skorochennia sertsevoho m'iaza shchura.