Prediction of human pharmacokinetics of panipenem, a new carbapenem antibiotic, from animal data.
The prediction of human pharmacokinetics of Panipenem (PAPM), which is a new carbapenem antibiotic, was investigated using animal data. The plasma concentration-time curve after intravenous administration of PAPM in each animal showed biexponential elimination. There were good allometric correlations between pharmacokinetic parameters (CLtotal and Vd,ss) calculated from the plasma concentration in animal species and body weight of experimental animals. Predicted human pharmacokinetic parameters calculated by these allometric equations agreed with the values observed in humans.
Nakashima
M
M
Department of Pharmacology, Hamamatsu University, School of Medicine, Shizuoka, Japan.
Kurihara
A
A
Hisaoka
M
M
D000328:Adult; D000818:Animals; D004285:Dogs; D006168:Guinea Pigs; D006801:Humans; D007223:Infant; D008252:Macaca fascicularis; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D008875:Middle Aged; D008954:Models, Biological; D011237:Predictive Value of Tests; D011817:Rabbits; D051381:Rats; D017208:Rats, Wistar; D013845:Thienamycins / Q000097:blood / Q000493:pharmacokinetics*
D013845:Thienamycins; C039536:panipenem