[Blood glucose, insulin, GH, and amino acids in rats receiving 3 levels of dietary proteins].
The effect of dietary protein content on the variations in plasma insulin, GH, glucose and both gluconeogenic and branched-chain amino acids (BCAA) levels, was studied in Wistar rats. For 21 days animals consumed ad libitum diets containing 4% (LP group) 10% (MP group) or 20% (HP group) protein. Body weight gain and plasma concentrations of the glucose, insulin and both the insulin/glucose (I/G) and insulin/GH (I/GH) ratios varied directly with the protein content of the diet. In contrast the relationships between dietary protein content and GH levels, were inverse. These results indicate that an increase of energy yielding nutrients availability and an decrease of tissue sensitivity to insulin was produced as the protein content of the diet was increased. The increase of plasma aspartate, serine, histidine and alanine levels on LP group suggest a low gluconeogenic process, and the higher rate of BCAA on HP group against to MP and LP groups can be related to a lower tissue uptake. Both effects can be mediated by the tissular sensitivity to insulin.
Muñoz-Martínez
E
E
Facultad de Farmacia, Universidad Complutense de Madrid, España.
Unzaga
M T
MT
Jiménez Gancedo
B
B
Rely de Viñas
J L
JL
D000596:Amino Acids / Q000097:blood*; D000818:Animals; D001786:Blood Glucose / Q000032:analysis*; D004044:Dietary Proteins / Q000008:administration & dosage* / Q000378:metabolism; D013006:Growth Hormone / Q000097:blood*; D007328:Insulin / Q000097:blood*; D051381:Rats; D017208:Rats, Wistar; D015430:Weight Gain
D000596:Amino Acids; D001786:Blood Glucose; D004044:Dietary Proteins; D007328:Insulin; D013006:Growth Hormone
Glucosa, insulina, GH y aminoácidos plásmaticos en ratas sometidas a tres niveles de proteína dietarios.