Expression and release of neuroregulators during development: monoamines and neuropeptides.
The turnover of catecholamines (CA) was determined in the adrenal medulla and brain of rat fetuses and pups. In general we found a considerable increase soon after birth. The expression of mRNA for CA-synthesizing enzymes was also considerably enhanced in the adrenals shortly after birth. Furthermore, we demonstrated increased expression of neuropeptides after birth, increased synthesis of mRNA encoding for neuropeptide Y in the adrenals 24 h after birth; and considerable activation of the substance P gene in a respiratory nuclei of rabbit pups which had been breathing for 2 h as compared with fetuses at term.
Lagercrantz
H
H
Department of Pediatrics and Neurophysiology, Karolinska Institute, Stockholm, Sweden.
Holgert
H
H
Pequignot
J M
JM
Srinivasan
M
M
D000313:Adrenal Medulla / Q000254:growth & development* / Q000378:metabolism; D000818:Animals; D015306:Biogenic Monoamines / Q000096:biosynthesis* / Q000378:metabolism; D001921:Brain / Q000254:growth & development*; D001923:Brain Chemistry / Q000502:physiology*; D005260:Female; D009479:Neuropeptides / Q000096:biosynthesis* / Q000378:metabolism; D011247:Pregnancy; D051381:Rats
D015306:Biogenic Monoamines; D009479:Neuropeptides