title: Simian virus 40 (SV40) small t antigen inhibits SV40 DNA replication in vitro.
abstract: We describe a biochemical function of simian virus 40 small t antigen, the inhibition of simian virus 40 large T antigen-mediated viral DNA replication in an in vitro replication system. Our results suggest that in this system, small t antigen prevents protein phosphatase 2A-mediated activation of large T antigen.
authors.affiliation: Section on Viruses and Cellular Biology, National Institute of Child Health and Human Development, Bethesda, Maryland 20892.
authors.forename: M
authors.initials: M
authors.lastname: Carbone
authors.forename: J
authors.initials: J
authors.lastname: Hauser
authors.forename: M P
authors.initials: MP
authors.lastname: Carty
authors.forename: K
authors.initials: K
authors.lastname: Rundell
authors.forename: K
authors.initials: K
authors.lastname: Dixon
authors.forename: A S
authors.initials: AS
authors.lastname: Levine
mesh_terms: D000952:Antigens, Polyomavirus Transforming / Q000502:physiology*; D002472:Cell Transformation, Viral; D002474:Cell-Free System; D004261:DNA Replication; D004279:DNA, Viral / Q000096:biosynthesis; D006367:HeLa Cells; D006801:Humans; D066298:In Vitro Techniques; D010749:Phosphoprotein Phosphatases / Q000378:metabolism; D054648:Protein Phosphatase 2; D013539:Simian virus 40 / Q000235:genetics*; D014779:Virus Replication
chemical_list: D000952:Antigens, Polyomavirus Transforming; D004279:DNA, Viral; D010749:Phosphoprotein Phosphatases; D054648:Protein Phosphatase 2