title: Chlorpheniramine inhibits the ornithine decarboxylase induction of Ehrlich carcinoma growing in vivo.
abstract: The antihistaminic (+/-)-chlorpheniramine significantly reduced the progression of Ehrlich carcinoma when it was administered at 0.5 mg/mouse/day from the third day on, after tumour inoculation. The ODC activity of tumour cells was diminished by 70% on day 7 after tumour transplantation, when maximum ODC activity is detected in non-treated tumour growing 'in vivo'. Northern blot analyses indicated that the inhibitory effect of this 1,4-diamine takes place at a post-transcriptional level. Results obtained from serum-free cultured cells indicated that chlorpheniramine inhibits the ODC synthesis rate.
authors.affiliation: Cátedra de Bioquímica y Biología Molecular, Facultad de Ciencias, Universidad de Málaga, Spain.
authors.forename: J L
authors.initials: JL
authors.lastname: Urdiales
authors.forename: J M
authors.initials: JM
authors.lastname: Matés
authors.forename: I
authors.initials: I
authors.lastname: Núñez de Castro
authors.forename: F M
authors.initials: FM
authors.lastname: Sánchez-Jiménez
mesh_terms: D000818:Animals; D002286:Carcinoma, Ehrlich Tumor / Q000188:drug therapy / Q000201:enzymology* / Q000473:pathology; D002455:Cell Division / Q000187:drug effects; D002744:Chlorpheniramine / Q000494:pharmacology*; D004790:Enzyme Induction / Q000187:drug effects; D051379:Mice; D009955:Ornithine Decarboxylase / Q000096:biosynthesis / Q000187:drug effects*; D065108:Ornithine Decarboxylase Inhibitors; D012333:RNA, Messenger / Q000187:drug effects; D014407:Tumor Cells, Cultured / Q000187:drug effects
chemical_list: D065108:Ornithine Decarboxylase Inhibitors; D012333:RNA, Messenger; D002744:Chlorpheniramine; D009955:Ornithine Decarboxylase