title: Osteoblasts and chondrocytes are important target cells for the toxic effects of lead.
abstract: The skeleton is a major repository for divalent cations, including toxic heavy metals such as lead. Unfortunately the effects of such agents on bone (and cartilage) have been minimally investigated in the past. With the current level of understanding of the mechanisms of bone formation and cartilage development it is now appropriate to begin to research the effects of lead on cellular processes. The following discussion describes some of the points of regulation in bone and cartilage formation where interference in metabolic processes could compromise the development of normal tissues as well as affect the homeostatic mechanisms of the skeleton.
authors.affiliation: Department of Orthopaedics, University of Rochester School of Medicine, New York 14642.
authors.forename: J E
authors.initials: JE
authors.lastname: Puzas
authors.forename: M J
authors.initials: MJ
authors.lastname: Sickel
authors.forename: M E
authors.initials: ME
authors.lastname: Felter
mesh_terms: D000818:Animals; D001846:Bone Development / Q000187:drug effects*; D002356:Cartilage / Q000166:cytology / Q000187:drug effects*; D006801:Humans; D007854:Lead / Q000633:toxicity*; D007855:Lead Poisoning / Q000473:pathology*; D008566:Membranes / Q000502:physiology; D008954:Models, Biological; D010006:Osteoblasts / Q000187:drug effects*; D012307:Risk Factors
chemical_list: D007854:Lead