A comparison of risk factors in juvenile-onset and adult-onset recurrent respiratory papillomatosis.
The clinical triad of a firstborn delivered vaginally to a young (teenage) mother has been previously noted among juvenile onset recurrent respiratory papillomatosis (JO-RRP) patients. This study was based on a questionnaire survey of JO-RRP patients, adult onset recurrent respiratory papillomatosis (AO-RRP) patients, and juvenile and adult controls. The survey results revealed that the complete or partial triad was observed in 72% of JO-RRP patients, 36% of AO-RRP patients, 29% of juvenile controls, and 38% of adult controls. As compared with juvenile controls, JO-RRP patients were more often firstborn (P less than .05), delivered vaginally (P less than .05), and born to a teenage mother (P less than .01). Among adult participants, AO-RRP patients reported more lifetime sex partners (P less than .01) and a higher frequency of oral sex (P less than .05) than reported by adult controls. AO-RRP and JO-RRP appear to have distinguishable epidemiologic features indicating that the mode of human papillomavirus (HPV) transmission is different in these two disorders.
Kashima
H K
HK
Department of Otolaryngology-Head and Neck Surgery, Johns Hopkins Medical Institutions, Baltimore, MD.
Shah
F
F
Lyles
A
A
Glackin
R
R
Muhammad
N
N
Turner
L
L
Van Zandt
S
S
Whitt
S
S
Shah
K
K
D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D001722:Birth Order; D002648:Child; D002675:Child, Preschool; D003043:Cocarcinogenesis; D036861:Delivery, Obstetric; D005260:Female; D006801:Humans; D008297:Male; D008423:Maternal Age; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local; D010212:Papilloma / Q000453:epidemiology*; D027383:Papillomaviridae; D012142:Respiratory Tract Neoplasms / Q000453:epidemiology*; D012307:Risk Factors; D012725:Sexual Behavior; D012747:Sexual Partners; D014412:Tumor Virus Infections / Q000453:epidemiology* / Q000635:transmission