title: Antitumor activity of new antitumor substance, polyoxomolybdate, against several human cancers in athymic nude mice.
abstract: Antitumor polyoxomolybdates have been recognized in the course of study on the medical utilization of polyoxometalates, inorganic polymers of metal oxide. [NH3Pri]6[Mo7O24].3H2O (PM-8) was found as a representative of antitumor polyoxomolybdates. The growth suppressions of PM-8 against Co-4 human colon cancer xenografted under the subrenal capsule in cd-1 mice were equal or superior to that of 5-FU, MMC, ACNU, ADM and CDDP. Potent antitumor activity of PM-8 is also established against MX-1 human breast and OAT human lung cancer xenografted in athymic nude mice. Polyoxomolybdate is a new type of antitumor substance.
authors.affiliation: Division of Chemotherapy, Keio University, Tokyo, Japan.
authors.forename: H
authors.initials: H
authors.lastname: Fujita
authors.forename: T
authors.initials: T
authors.lastname: Fujita
authors.forename: T
authors.initials: T
authors.lastname: Sakurai
authors.forename: T
authors.initials: T
authors.lastname: Yamase
authors.forename: Y
authors.initials: Y
authors.lastname: Seto
mesh_terms: D000818:Animals; D001943:Breast Neoplasms / Q000188:drug therapy* / Q000473:pathology; D003110:Colonic Neoplasms / Q000188:drug therapy* / Q000473:pathology; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000188:drug therapy* / Q000473:pathology; D051379:Mice; D008819:Mice, Nude; D008958:Models, Molecular; D008982:Molybdenum / Q000627:therapeutic use*; D009368:Neoplasm Transplantation; D010087:Oxides / Q000627:therapeutic use*; D013370:Subrenal Capsule Assay
chemical_list: D010087:Oxides; C081971:PM 8; D008982:Molybdenum