Induction of tumours of the haematopoietic system by cadmium in rats.
Several of our recent studies in rats indicate an association between exposure to cadmium and haematopoietic tumours. In the first study, male WF rats received dietary cadmium (0-200 micrograms/g cadmium as cadmium chloride) for up to 77 weeks. A dose-related increase in large granular lymphocyte (LGL) leukaemia was observed with a maximal incidence in rats fed 100 micrograms/g cadmium. In a second study, male F344 rats received a single high dose of cadmium chloride (30 mumol/kg, s.c.) and were observed for 90 weeks. The high natural incidence of leukaemia in these rats (24%) was markedly reduced (6%) by this dose of cadmium. The paradoxical effects of cadmium on haematopoietic tumours may be the result of a dose-related spectrum of lymphotoxicity ranging from cell-specific cytotoxicity and carcinogenicity to destruction of key progenitor cell populations.
Waalkes
M P
MP
Inorganic Carcinogenesis Section, Frederick Cancer Research and Development Center, MD 21702.
Rehm
S
S
Sass
B
B
Ward
J M
JM
D000818:Animals; D002104:Cadmium / Q000633:toxicity*; D006402:Hematologic Diseases / Q000139:chemically induced*; D007945:Leukemia, Lymphoid / Q000139:chemically induced; D008297:Male; D009374:Neoplasms, Experimental / Q000139:chemically induced*; D051381:Rats; D011916:Rats, Inbred F344; D011920:Rats, Inbred WF
D002104:Cadmium