[The structural bases of the cardiotoxic action of the anti-tumor antibiotic carminomycin].
The authors substantiate morphological and structural-functional basis of the cardiotoxic effect of the antitumor anthracycline antibiotic carminomycin after its single intraperitoneal administration in maximum tolerable doses. Results indicate that the cause of development of cardiac failure after administration of carminomycin to experimental animals in the development of an alternative and plastic cardiac failure prevalence of type I.
Ishchenko
V E
VE
Blagodarov
V N
VN
Kulik
G I
GI
Grigor'eva
N N
NN
D000818:Animals; D002360:Carubicin / Q000633:toxicity*; D004305:Dose-Response Relationship, Drug; D006321:Heart / Q000187:drug effects* / Q000503:physiopathology; D006651:Histocytochemistry; D051379:Mice; D008810:Mice, Inbred C57BL; D008854:Microscopy, Electron; D009206:Myocardium / Q000201:enzymology / Q000473:pathology; D013997:Time Factors
D002360:Carubicin
Strukturnye osnovy kardiotoksicheskogo deĭstviia protivoopukholevogo antibniotika karminomitsina.