Kallmann syndrome gene on the X and Y chromosomes: implications for evolutionary divergence of human sex chromosomes.
The recently identified gene for X-linked Kallmann syndrome (hypogonadotropic hypogonadism and anosmia) has a closely related homologue on the Y chromosome. The X and Y copies of this gene are located in a large region of X/Y homology, on Xp22.3 and Yq11.2, respectively. Comparison of the structure of the X-linked Kallmann syndrome gene and its Y homologue shed light on the evolutionary history of this region of the human sex chromosomes. Our data show that the Y homologue is not functional. Comparative analysis of X/Y sequence identity at several loci on Xp22.3 and Yq11.2 suggests that the homology between these two regions is the result of a complex series of events which occurred in the recent evolution of sex chromosomes.
Incerti
B
B
Institute for Molecular Genetics, Baylor College of Medicine, Houston, Texas 77030.
Guioli
S
S
Pragliola
A
A
Zanaria
E
E
Borsani
G
G
Tonlorenzi
R
R
Bardoni
B
B
Franco
B
B
Wheeler
D
D
Ballabio
A
A
D001483:Base Sequence; D005075:Biological Evolution; D002874:Chromosome Mapping; D004247:DNA / Q000235:genetics; D005091:Exons; D006801:Humans; D017436:Kallmann Syndrome / Q000235:genetics*; D008297:Male; D008969:Molecular Sequence Data; D012689:Sequence Homology, Nucleic Acid; D014960:X Chromosome; D014998:Y Chromosome
D004247:DNA