Effects of antihypertensive treatment with beta-blockers on glucose metabolism.
The beneficial effects of beta-blockers on morbidity and mortality in both essential hypertension and diabetes mellitus have been demonstrated in several antihypertensive trial. Recently, negative side effects of beta-blockers on glucose metabolism have been suggested that could limit their wide-spread use. However, on detailed analysis, any side effects of beta 1-selective beta-blockers on glucose metabolism do not appear to be relevant for clinical practice and hence do not restrict the use of these agents as first-line antihypertensive drugs in diabetic and nondiabetic patients.
Sawicki
P T
PT
Department of Nutrition and Metabolism, WHO Collaborating Centre for Diabetes, Heinrich-Heine University, Düsseldorf, Germany.
Berger
M
M
D000319:Adrenergic beta-Antagonists / Q000009:adverse effects* / Q000627:therapeutic use; D000818:Animals; D005947:Glucose / Q000378:metabolism*; D006801:Humans; D006973:Hypertension / Q000188:drug therapy / Q000378:metabolism*
D000319:Adrenergic beta-Antagonists; D005947:Glucose