Effect of Ukrain on the efficacy of anti-epileptic drugs against maximal electroshock-induced seizures in mice.
It has been found that Ukrain, given intraperitoneally (i.p.), did not influence the threshold for maximal electroconvulsions in mice. Ukrain in doses of 9.5 and 19 mg/kg significantly enhanced the protective efficacy of valproate, decreasing the ED50 values. However, Ukrain had no effect on the protection provided by diazepam, carbamazepine, diphenylhydantoin and phenobarbital. The combined treatment with Ukrain and anti-epileptic drugs did not cause any signs of toxicity.
Jagiełło-Wójtowicz
E
E
Department of Pharmacology, Medical Academy, Lublin, Poland.
Kleinrok
Z
Z
Feldo
M
M
Chodkowska
A
A
Nowicky
J W
JW
D000470:Alkaloids / Q000008:administration & dosage / Q000494:pharmacology*; D000818:Animals; D000927:Anticonvulsants / Q000494:pharmacology*; D001600:Berberine Alkaloids; D004347:Drug Interactions; D004597:Electroshock; D007274:Injections, Intraperitoneal; D008297:Male; D051379:Mice; D010617:Phenanthridines; D012640:Seizures / Q000517:prevention & control*
D000470:Alkaloids; D000927:Anticonvulsants; D001600:Berberine Alkaloids; D010617:Phenanthridines; C060921:ukrain