Molecular mechanisms for controlling spontaneous and induced mutagenesis.
Errors in the replication of DNA are a major source of spontaneous mutations, and a number of cellular functions are involved in correction of these errors to keep the frequency of spontaneous mutations very low. We report here a novel mechanism which prevents replicational errors by degrading a potent mutagenic substrate for DNA synthesis. We also deal with suppression of alkylation-induced mutations by O6-methylguanine-DNA methyltransferase.
Sekiguchi
M
M
Department of Biochemistry, Faculty of Medicine, Kyushu University, Fukuoka, Japan.
Mo
J Y
JY
Maki
H
H
D000478:Alkylation; D001426:Bacterial Proteins / Q000378:metabolism; D004258:DNA Polymerase III / Q000378:metabolism; D004261:DNA Replication; D004269:DNA, Bacterial / Q000096:biosynthesis / Q000378:metabolism; D004926:Escherichia coli / Q000201:enzymology; D029968:Escherichia coli Proteins; D006147:Guanine / Q000031:analogs & derivatives / Q000378:metabolism; D008780:Methyltransferases / Q000378:metabolism; D016296:Mutagenesis; D019853:O(6)-Methylguanine-DNA Methyltransferase; D010084:Oxidation-Reduction; D010744:Phosphoric Monoester Hydrolases; D011755:Pyrophosphatases
D001426:Bacterial Proteins; D004269:DNA, Bacterial; D029968:Escherichia coli Proteins; C024829:8-hydroxyguanine; D006147:Guanine; D008780:Methyltransferases; D019853:O(6)-Methylguanine-DNA Methyltransferase; D004258:DNA Polymerase III; D010744:Phosphoric Monoester Hydrolases; D011755:Pyrophosphatases; C052211:mutT protein, E coli