[Inhibiting effect of domestic, synthetic beta-carotene and ascorbic acid on endogenous carcinogenesis in mice].
Carcinogenesis in mice induced by the tryptophane derivative 3-hydroxyanthranilic acid was studied after administration of synthetic beta-carotene and ascorbic acid. The incidence of induced hemoblastoses and hepatomas was decreased 2-fold, while the latent period of their development was, increased in mice on a lifetime feed containing 15 mg/kg of beta-carotene. The anticarcinogenic effect of ascorbic acid added to drinking water was similar to that of beta-carotene. The additive inhibitory influence of beta-carotene and ascorbic acid on endogenous blastomogenesis was not found in mice.
Sergeeva
T I
TI
Vakulova
L A
LA
Zhidkova
T A
TA
Sergeev
A V
AV
D015095:3-Hydroxyanthranilic Acid; D000818:Animals; D001205:Ascorbic Acid / Q000627:therapeutic use*; D002338:Carotenoids / Q000627:therapeutic use*; D008114:Liver Neoplasms, Experimental / Q000139:chemically induced / Q000517:prevention & control*; D051379:Mice; D008810:Mice, Inbred C57BL; D019207:beta Carotene
D019207:beta Carotene; D015095:3-Hydroxyanthranilic Acid; D002338:Carotenoids; D001205:Ascorbic Acid
Ingibiruiushchee vliianie otechestvennogo sinteticheskogo beta-karotinai askorbinovoĭ kisloty na éndogennyĭ kantserogenez mysheĭ.