title: An experimental study to examine the patency and tissue response of two types of biosynthetic graft used as a replacement for porcine inferior vena cava.
abstract: This experimental study has been carried out to evaluate biosynthetic grafts as vascular substitutes. Tubular segments of 35 x 8 mm made of (1) tanned ovine collagen and integral polyester mesh, either of the first (Omniflow I) or second generation (Omniflow II), or (2) polytetrafluoroethylene (e-PTFE), have been sutured in the infrarenal inferior vena cava of pigs, and removed 1 hour, 7, 14, 28, 56 and 112 days after implantation. The patency rate of biosynthetic grafts was higher than that of e-PTFE grafts (p < 0.01). There was no significant difference between the patency of the first generation and second generation collagen grafts. These results indicate that biosynthetic prostheses may be suitable vascular substitutes in low flow and low pressure systems. Improvements in the collagen inner cover structure (Omniflow II vs. Omniflow I), producing greater mechanical endurance, did not enhance long-term patency or the healing patterns of biosynthetic grafts.
authors.affiliation: Istituto di Patologia Chirurgica, Università degli Studi di Genova, Italy.
authors.forename: G B
authors.initials: GB
authors.lastname: Ratto
authors.forename: A
authors.initials: A
authors.lastname: Leprini
authors.forename: P
authors.initials: P
authors.lastname: Romano
authors.forename: G
authors.initials: G
authors.lastname: Fantino
authors.forename: E
authors.initials: E
authors.lastname: Tassara
authors.forename: D
authors.initials: D
authors.lastname: Zaccheo
mesh_terms: D000818:Animals; D001705:Bioprosthesis; D001807:Blood Vessel Prosthesis; D005976:Glutaral; D011093:Polyethylene Terephthalates; D011474:Prosthesis Design; D011475:Prosthesis Failure; D013552:Swine; D014654:Vascular Patency; D014682:Vena Cava, Inferior / Q000601:surgery* / Q000648:ultrastructure
chemical_list: D011093:Polyethylene Terephthalates; D005976:Glutaral