[The characteristics of thrombocyte morphological structure in patients with endogenous depression during antidepressant therapy].
The study of platelets surface in patients with endogenous depressions made before the beginning of therapy, 1-3 days later and during the first days of clinical recovery with scanning electron microscopy showed that the platelets of patients who had not received antidepressants were activated. More marked activation took place after long-term therapy in the form of platelets with distinct pseudopodia, which were 2-3 times longer than cells body and with inclination to form large aggregations. This cell type is also characterized by formation of a new type of rod platelets. It is suggested that antidepressants accumulation takes place on cell membrane during long-term therapy that causes selective or general increase of membranes permeability, cytotoxicity.
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D000293:Adolescent; D000328:Adult; D000928:Antidepressive Agents / Q000627:therapeutic use*; D001714:Bipolar Disorder / Q000097:blood / Q000188:drug therapy; D001792:Blood Platelets / Q000187:drug effects / Q000648:ultrastructure*; D003866:Depressive Disorder / Q000097:blood* / Q000188:drug therapy; D005260:Female; D006801:Humans; D008855:Microscopy, Electron, Scanning; D008875:Middle Aged; D011554:Pseudopodia / Q000187:drug effects / Q000648:ultrastructure; D013499:Surface Properties; D013997:Time Factors
D000928:Antidepressive Agents
Osobennosti morfologicheskoĭ struktury trombotsitov bol'nykh éndogennymi depressiiami v protsesse terapii antidepressantami.