[The study of biological monitoring index for human exposed to BaP].
This paper studied the relationships among urinary BaP, Plasma BaP and SCE in rats and also analysed humans date. The results of animal experiments showed urinary BaP concentration were significantly correlated with BaP in plasma (r = 0.814, P < 0.01) and with the difference of the SCE frequency before and after BaP administration (r = 0.934, P < 0.01). The analytical results of humans data showed similar linear relationship between urinary BaP concentration and the level of exposure to BaP (r = 0.987, P < 0.0005), and also showed a positive correlation between the concentration of urinary BaP and the SCE frequency (r = 0.733, P < 0.05). We suggest the use of urinary BaP analysis as a biological monitoring index for exposure to BaP.
Song
Y J
YJ
School of Public Health, Beijing Medical University.
D000328:Adult; D000393:Air Pollutants / Q000652:urine*; D000397:Air Pollution / Q000009:adverse effects* / Q000032:analysis; D000818:Animals; D001564:Benzo(a)pyrene / Q000032:analysis*; D004781:Environmental Exposure; D005260:Female; D006801:Humans; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley; D012854:Sister Chromatid Exchange
D000393:Air Pollutants; D001564:Benzo(a)pyrene