Effects of GABA receptor stimulation on the release of [3H]GABA from slices of rat neostriatum.
Slices of rat neostriatum were incubated in Krebs-Henseleit medium. Modulation of [3H]GABA release by GABA agonists and antagonists was investigated. The GABAA receptor agonists muscimol (0.1 microM) and isoguvacine (5 microM) enhanced the stimulated release of [3H]GABA. The antagonists picrotoxin (1 microM) and bicuculline (50 microM) prevented the effects of the agonists. In the presence of naloxone (1 microM), which blocked the effects of enkephalinergic neurons within the slice preparation, muscimol (1 microM) no longer affected the release of [3H]GABA.
Meyer
D K
DK
Department of Pharmacology, University of Freiburg, F.R.G.
Conzelmann
U
U
Müller
A
A
D000818:Animals; D003292:Convulsants / Q000494:pharmacology; D003342:Corpus Striatum / Q000187:drug effects / Q000378:metabolism*; D058787:GABA-A Receptor Antagonists; D007539:Isonicotinic Acids / Q000494:pharmacology; D008297:Male; D009118:Muscimol / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D011963:Receptors, GABA-A / Q000187:drug effects*; D015222:Sodium Channels / Q000187:drug effects; D013779:Tetrodotoxin / Q000494:pharmacology; D005680:gamma-Aminobutyric Acid / Q000378:metabolism*
D003292:Convulsants; D058787:GABA-A Receptor Antagonists; D007539:Isonicotinic Acids; D011963:Receptors, GABA-A; D015222:Sodium Channels; D009118:Muscimol; D013779:Tetrodotoxin; D005680:gamma-Aminobutyric Acid; C015300:isoguvacine