Expression of IgA and IgM Fc receptors on murine T lymphocytes.
Fc receptors are induced on T cells following activation via the TCR. T cells that express Fc receptors transiently have the ability to use two different cognate systems: the TCR and immunoglobulins bound to the Fc receptors. The studies discussed in this article are focused on the Fc alpha and Fc mu receptors that can be induced on certain subsets of murine T lymphocytes. The article emphasizes the role of the T cell receptor for antigen in the expression of Fc alpha and Fc mu receptors on murine T cells and reviews experimental observations that suggest significant molecular heterogeneity of these Fc receptors. The finding that regulation of expression of Fc alpha receptors and Fc mu receptors on T lymphocytes is linked to cellular activation via the CD3/TCR complex implies that these Fc receptors might mediate important functions in the biology and pathology of T cells.
Sandor
M
M
Department of Pathology, University of Iowa College of Medicine, Iowa City 52242.
Ibraghimov
A
A
Rosenberg
M G
MG
Teeraratkul
P
P
Lynch
R G
RG
D000818:Animals; D015703:Antigens, CD; D002462:Cell Membrane / Q000276:immunology; D007070:Immunoglobulin A / Q000378:metabolism; D007075:Immunoglobulin M / Q000378:metabolism; D051379:Mice; D011948:Receptors, Antigen, T-Cell / Q000378:metabolism; D011961:Receptors, Fc / Q000378:metabolism*; D013601:T-Lymphocytes / Q000276:immunology*
D015703:Antigens, CD; C036832:Fc(alpha) receptor; D007070:Immunoglobulin A; D007075:Immunoglobulin M; D011948:Receptors, Antigen, T-Cell; D011961:Receptors, Fc; C035311:immunoglobulin M receptor