title: [Perioperative remote infections in neurosurgery. Role of antibiotic prophylaxis].
abstract: We report the results of a randomized, prospective study devised to assess the effectiveness of perioperative cefamandole prophylaxis on the remote infections rate in neurosurgery. Only two kinds of neurosurgical procedures were studied: shunt placement and craniotomy for brain tumour. In the treated patients cefamandole 1.5 g was given one hour before surgery, then repeated twice eight hourly. When the surgical procedure lasted more than three hours cefamandole 1.5 g was administered throughout the operation. No case of local infection was observed in either group, and the percentage of patients with remote infections was the same in both groups. Leucocytosis and temperature were measured during 15 days following the surgical procedure, and there were no differences between the treated and untreated groups in the evolution of these parameters. This study does not suggest that routine perioperative antibiotic prophylaxis is mandatory in neurosurgery.
authors.affiliation: Département d'Anesthésie-Réanimation, Hôpital Sainte-Marguerite, Marseille.
authors.forename: B
authors.initials: B
authors.lastname: Rocca
authors.forename: M N
authors.initials: MN
authors.lastname: Mallet
authors.forename: F
authors.initials: F
authors.lastname: Scemama
authors.forename: S
authors.initials: S
authors.lastname: Malca
authors.forename: A
authors.initials: A
authors.lastname: Chevalier
authors.forename: F
authors.initials: F
authors.lastname: Gouin
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D016470:Bacteremia / Q000382:microbiology / Q000517:prevention & control*; D001932:Brain Neoplasms / Q000601:surgery; D002435:Cefamandole / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D008171:Lung Diseases / Q000382:microbiology / Q000517:prevention & control*; D008297:Male; D008875:Middle Aged; D011182:Postoperative Care; D011183:Postoperative Complications; D011300:Preoperative Care; D011446:Prospective Studies; D014552:Urinary Tract Infections / Q000382:microbiology / Q000517:prevention & control*; D014946:Wound Infection / Q000517:prevention & control*
chemical_list: D002435:Cefamandole
vernacular_title: Infections à distance du foyer opératoire en neurochirurgie. Rôle de l'antibioprophylaxie.