title: No adaptive response of Chinese hamster ovary cells to low doses of ionizing radiation.
abstract: Chinese hamster ovary (CHO) cells that had been exposed to very low doses of ionizing radiation from incorporated tritiated thymidine or X-rays were shown not to be more resistant to the induction of chromatid aberrations by a subsequent higher dose of ionizing radiation than previously untreated cells. The adaptive response to ionizing radiation was absent both in cells challenged with high doses of X-rays (1.25 Gy) and in cells post-treated with thermal neutrons (0.5-1 x 10(12) n/cm2). In agreement with these observations in CHO cells we were unable to demonstrate an adaptive response to X-rays also in human lymphocytes from five different donors.
authors.affiliation: Department of Genetics, University of Uppsala, Sweden.
authors.forename: H C
authors.initials: HC
authors.lastname: Andersson
authors.forename: S
authors.initials: S
authors.lastname: Na Chiangmai
mesh_terms: D000222:Adaptation, Physiological; D000818:Animals; D016466:CHO Cells / Q000528:radiation effects*; D006224:Cricetinae; D011829:Radiation Dosage; D011839:Radiation, Ionizing