title: Microdistribution of lead in bone: a new approach.
abstract: A knowledge of the microdistribution of lead in bone is important in order to understand the mechanisms for accumulation and release of lead. The availability of the synchrotron x-ray microscope for sensitive measurements of bone content and distribution of lead provides a valuable tool which, when combined with kinetic, balance, and tissue measurements, can lead to better evaluation of lead toxicity. It may also provide the basis for the development of a suitable model of how lead behaves in the human body. An outline of an experimental protocol for exploitation of the x-ray microscope is given, along with synchrotron x-ray microscope measurements of the distribution of gallium in rat bone that demonstrate the feasibility of the experimental approach.
authors.affiliation: Brookhaven National Laboratory, Upton, New York 11973.
authors.forename: K W
authors.initials: KW
authors.lastname: Jones
authors.forename: R S
authors.initials: RS
authors.lastname: Bockman
authors.forename: F
authors.initials: F
authors.lastname: Bronner
mesh_terms: D000818:Animals; D001842:Bone and Bones / Q000737:chemistry*; D004577:Electron Probe Microanalysis; D005708:Gallium / Q000032:analysis; D006801:Humans; D007854:Lead / Q000032:analysis*; D017356:Synchrotrons
chemical_list: D007854:Lead; D005708:Gallium