The influence of tuftsin partial sequences on histamine level in guinea pig and rat tissues.
We investigated the influence of tuftsin partial sequences (Thr-Lys, Lys-Pro, Lys-Pro-Arg and Pro-Arg) on histamine concentration in selected tissues (lungs, kidneys, liver, duodenal wall and arterial blood) of guinea-pigs and rats. The peptides were administered in 1 mg/kg dose intravenously (single dose) or intraperitoneally (single dose or three doses at one-hour intervals). Histamine concentration was determined spectrofluorimetrically. Tissues used in the determination were taken 1 hour after the last injection. It was found that Pro-Arg and Lys-Pro-Arg (similarly to tuftsin), lower histamine concentration in lungs, and elevate it in kidneys.
Paradowski
A
A
Department of Physiology, Pomeranian Medical Academy, Szczecin, Poland.
Rózga
M
M
Wronowska
G
G
Nawrocka-Bolewska
E
E
Siemion
I Z
IZ
D000595:Amino Acid Sequence; D000818:Animals; D006168:Guinea Pigs; D006632:Histamine / Q000378:metabolism*; D007668:Kidney / Q000187:drug effects / Q000378:metabolism; D008099:Liver / Q000187:drug effects / Q000378:metabolism; D008168:Lung / Q000187:drug effects / Q000378:metabolism; D008969:Molecular Sequence Data; D010446:Peptide Fragments / Q000008:administration & dosage / Q000737:chemistry / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D013329:Structure-Activity Relationship; D014018:Tissue Distribution; D014405:Tuftsin / Q000008:administration & dosage / Q000737:chemistry / Q000494:pharmacology*
D010446:Peptide Fragments; D006632:Histamine; D014405:Tuftsin