Long-acting local anesthetics in dentistry.
Long-acting local anesthetics have proved to be effective for the suppression of both intraoperative and postoperative pain. They are useful for lengthy dental treatments and for prevention of severe pain following many types of surgical procedures. Although the currently available long-acting local anesthetics for dentistry have minimal side effects in the doses usually employed, there are potential problems. Bupivacaine, for example, can cause significant cardiac depressant and dysrhythmogenic responses. Etidocaine has less pronounced effects on the cardiovascular system, but its use may be associated with inadequate control of intraoperative bleeding. A new long-acting local anesthetic, ropivacaine, appears to offer advantages over either of the currently used long-acting agents.
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Department of Oral and Maxillofacial Surgery, Medical College of Georgia School of Dentistry, Augusta 30912.
D000577:Amides / Q000737:chemistry / Q000494:pharmacology; D000766:Anesthesia, Dental / Q000379:methods*; D000779:Anesthetics, Local / Q000737:chemistry / Q000494:pharmacology; D000818:Animals; D002045:Bupivacaine / Q000737:chemistry / Q000494:pharmacology; D005041:Etidocaine / Q000737:chemistry / Q000494:pharmacology; D006801:Humans; D008012:Lidocaine; D000077212:Ropivacaine; D013997:Time Factors
D000577:Amides; D000779:Anesthetics, Local; D000077212:Ropivacaine; D008012:Lidocaine; D005041:Etidocaine; D002045:Bupivacaine