[The correction of metabolic acidosis by the instillation of 0.1N sodium hydroxide in an experimental model].
The critically ill patient, during the natural course of the disease often presents acid-base disturbances acidosis being the most common metabolic problem. Sodium bicarbonate has been used, for its correction but due to complications its use is restricted. In the present experimental study, mixed race dogs were artificially induced metabolic acidosis with in chloride acid. Arterial and venous blood gases were determined. Afterwards 0.1N sodium hydroxide was administered in the same amount statistically demonstrating modifications, in the pH values, as well as an excess of arterial and venous base which indicates the possibility of using this substance in humans to correct metabolic acidosis.
Alvarado Díez
R
R
Hospital de Especialidades, Centro Médico Nacional Siglo XXI, IMSS.
Ramírez Cabrera
J B
JB
Díaz de Léon Ponce
M
M
D000138:Acidosis / Q000139:chemically induced / Q000188:drug therapy* / Q000453:epidemiology; D000704:Analysis of Variance; D000818:Animals; D004195:Disease Models, Animal; D004285:Dogs; D004353:Drug Evaluation, Preclinical; D006851:Hydrochloric Acid; D006863:Hydrogen-Ion Concentration; D012972:Sodium Hydroxide / Q000008:administration & dosage*; D012996:Solutions
D012996:Solutions; D012972:Sodium Hydroxide; D006851:Hydrochloric Acid
Corrección de la acidosis metabólica con instilación de hidróxido de sodio al 0.1N en un modelo experimental.