Role of pi form of glutathione S-transferase (GST-pi) in cancer: a minireview.
The pi class of the glutathione S-transferases is the most abundant of the human glutathione S-transferases family and is expressed almost in all tissues. However, the role of this protein is still poorly defined. It is suggested that this protein may serve as a marker for malignant transformation in some tissues. Additionally it seems that the phenomenon of tumour drug resistance may depend on the elevation of the glutathione S-transferase-pi. In this article we have attempted to review present knowledge concerning above problems.
Gajewska
J
J
Department of Biochemistry, National Research Institute of Mother and Child, Warszawa, Poland.
Szczypka
M
M
D005982:Glutathione Transferase / Q000502:physiology*; D006801:Humans; D007527:Isoenzymes / Q000502:physiology*; D009369:Neoplasms / Q000201:enzymology*; D009626:Terminology as Topic
D007527:Isoenzymes; D005982:Glutathione Transferase