[Effects of Panax notoginseng saponins on monophasic action potentials of heart and automaticity and contractility of isolated atria].
The effects of Panax notoginseng saponins (PNS) on monophasic action potentials (MAP) recorded from the myocardial surface by means of contact electrode were studied in 30 open-chest rabbits. The MAPA was increased and MAPD50, MAPD90 were prolonged with PNS (100, 200 mg.kg-1, iv), while the Vmax remained unchanged. PNS (300-1200 micrograms.ml-1) inhibited the automaticity of isolated guinea pig right atria and the contractility of the left atria. The positive inotropic action of ouabain (0.2 mumol.L-1) on isolated guinea pig left atria was decreased in the presence of PNS 300 micrograms.ml-1.
Chen
J Q
JQ
Department of Pathophysiology, Guilin Medical College, China.
Zhang
Y G
YG
Xiong
C
C
Zhang
S Z
SZ
Zeng
Q
Q
Rong
M Z
MZ
D000200:Action Potentials / Q000187:drug effects; D000818:Animals; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D005260:Female; D036145:Ginsenosides; D006168:Guinea Pigs; D006321:Heart / Q000502:physiology; D066298:In Vitro Techniques; D008297:Male; D009200:Myocardial Contraction / Q000187:drug effects*; D010042:Ouabain / Q000494:pharmacology; D011817:Rabbits; D012503:Saponins / Q000494:pharmacology*
D004365:Drugs, Chinese Herbal; D036145:Ginsenosides; C027816:San-Chi; D012503:Saponins; D010042:Ouabain