[Manifestation of oxygen effect during normobaric hypoxic hypoxia in the intrauterine and postnatal developmental periods].
The experiments on rats have shown that hypoxic gas mixture containing 10% of oxygen and 90% of nitrogen (HGM-10) under normobaric conditions exerts a highly reliable radioprotective effect on progeny when 11-day pregnant animals are exposed to total irradiation (60Co, 20 Gy). As distinct from the known radioprotector, mexamine, (5-methoxytryptamine), HGM-10 has a pronounced radioprotective effect during the first days (1-5) after birth. Radioresistance of new-born rats correlates with the level of pO2 in the tissues which progressively decreases with respiration of HGM-10 and remains unchanged after mexamine (10 mg/kg) introduction.
Chizhov
A Ia
AIa
Strelkov
R B
RB
D008735:5-Methoxytryptamine / Q000627:therapeutic use; D000818:Animals; D000831:Animals, Newborn; D005260:Female; D005333:Fetus / Q000187:drug effects* / Q000378:metabolism / Q000528:radiation effects; D008297:Male; D009584:Nitrogen / Q000494:pharmacology / Q000627:therapeutic use*; D010100:Oxygen / Q000494:pharmacology / Q000627:therapeutic use*; D010101:Oxygen Consumption; D011247:Pregnancy; D049188:Prenatal Injuries; D011833:Radiation Injuries, Experimental / Q000378:metabolism / Q000517:prevention & control*; D051381:Rats; D017208:Rats, Wistar; D012138:Respiratory Therapy
D008735:5-Methoxytryptamine; D009584:Nitrogen; D010100:Oxygen
Proiavlenie kislorodnogo éffekta v usloviiakh normobaricheskoĭ gipoksicheskoĭ gipoksii vo vnutriutrobnyĭ i postnatalńyĭ periody razvitiia.