The effect of cyclophosphamide pulses on fertility in patients with lupus nephritis.
The effect of cyclophosphamide pulse therapy given in relatively small doses (10 mg/kg per pulse) in 17 females with lupus nephritis has been studied. Four females developed menopause; in one transient amenorrhea occurred. No changes in menstrual cycle were noted in the other 11 females, four of whom subsequently delivered five normal babies. These data suggest the relative safety of small doses of cyclophosphamide pulse therapy on gonadal function in females under age 40 years.
Langevitz
P
P
Department of Internal Medicine F, Chaim Sheba Medical Center, Tel-Hashomer, Israel.
Klein
L
L
Pras
M
M
Many
A
A
D000293:Adolescent; D000305:Adrenal Cortex Hormones / Q000627:therapeutic use; D000328:Adult; D000568:Amenorrhea / Q000139:chemically induced*; D003131:Combined Modality Therapy; D003520:Cyclophosphamide / Q000008:administration & dosage / Q000009:adverse effects* / Q000494:pharmacology / Q000627:therapeutic use; D004359:Drug Therapy, Combination; D005260:Female; D005298:Fertility / Q000187:drug effects*; D006801:Humans; D008181:Lupus Nephritis / Q000188:drug therapy*; D008594:Menopause, Premature / Q000187:drug effects*; D008597:Menstrual Cycle / Q000187:drug effects; D008875:Middle Aged; D011247:Pregnancy; D011248:Pregnancy Complications; D006435:Renal Dialysis
D000305:Adrenal Cortex Hormones; D003520:Cyclophosphamide