[Isolated memory disorders disclosing antiphospholipid antibody syndrome].
Most of the neurological complications of the antiphospholipid syndrome are consequences of arterial or venous cerebral thromboses. We report the case of a 46-year-old woman presenting with the main signs of antiphospholipid syndrome: Raynaud's phenomenon, livedo, leg ulcers, repeated miscarriages, presence of a circulating anticoagulant and of antiphospholipid antibodies, who developed an isolated amnestic syndrome with a peculiar pattern; 1) almost complete sparing of the ability to learn new skills and of short-term recall; 2) deterioration, followed by disappearance of recent memories after a sufficient delay; 3) progressive alteration of increasingly old memories including knowledge memory suggested a gradual alteration of mnestic traces. The lack of neuroradiological signs of multiple infarcts suggests a direct intervention of antibodies in this patient's memorisation mechanisms.
Harle
J R
JR
Service de Médecine Interne, Hôpital de la Timone, Marseille.
Disdier
P
P
Ali Cherif
A
A
Swiader
L
L
Royere
M L
ML
Weiller
P J
PJ
D017152:Antibodies, Antiphospholipid / Q000302:isolation & purification; D016736:Antiphospholipid Syndrome / Q000150:complications*; D005260:Female; D006801:Humans; D008569:Memory Disorders / Q000209:etiology*; D008875:Middle Aged; D009483:Neuropsychological Tests
D017152:Antibodies, Antiphospholipid
Troubles mnésiques isolés révélant un syndrome des anticorps anti-phospholipides.