A 15p+ variant shown to be a t(Y;15) with fluorescence in situ hybridisation.
Prenatal diagnosis in two successive pregnancies revealed the karyotype 46,XX,15p+ (pat). Using the Y heterochromatic probe pHY3.4 and fluorescence in situ hybridisation, the variant 15 was identified as a t(Y;15)(q12;p11). Interphase scanning alone would have given a false result in both prenatal assessments and in the phenotypically normal father.
Neumann
A A
AA
Cytogenetics Laboratory, Children's Hospital, Camperdown, NSW, Australia.
Robson
L G
LG
Smith
A
A
D002884:Chromosomes, Human, Pair 15 / Q000648:ultrastructure*; D005260:Female; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D007231:Infant, Newborn; D007621:Karyotyping; D008297:Male; D014178:Translocation, Genetic; D014998:Y Chromosome / Q000648:ultrastructure*