[The inhibiting effect of epsilon-aminocaproic acid on the incidence of induced tumors of the esophagus, nervous system and kidneys].
The anticarcinogenic properties of epsilon-aminocaproic acid were studied in two rat models of carcinogenesis. Esophageal tumors were induced by oral instillations of a total dose of 54 mg/kg body weight N-methyl-N-benzylnitrosamine whereas tumors of the nervous system and kidney-by transplacental injection of 75 mg/kg body weight N-ethyl-N-nitrosourea. epsilon-Aminocaproic acid given at a concentration of 1 milligram drinking water at the post-initiation stage of the carcinogenesis was shown to inhibit the induction of cancer and papilloma of the esophagus, brain glioma, peripheral nerve neurinoma and mesenchymal tumors of the kidney.
Bespalov
V G
VG
Aleksandrov
V A
VA
Petrov
A S
AS
Troian
D N
DN
D015119:Aminocaproic Acid / Q000627:therapeutic use*; D000818:Animals; D016588:Anticarcinogenic Agents / Q000627:therapeutic use*; D002273:Carcinogens; D016009:Chi-Square Distribution; D004128:Dimethylnitrosamine / Q000031:analogs & derivatives; D004354:Drug Screening Assays, Antitumor; D004938:Esophageal Neoplasms / Q000139:chemically induced / Q000453:epidemiology / Q000517:prevention & control*; D005038:Ethylnitrosourea; D005260:Female; D015994:Incidence; D007680:Kidney Neoplasms / Q000139:chemically induced / Q000453:epidemiology / Q000517:prevention & control*; D008297:Male; D009423:Nervous System Neoplasms / Q000139:chemically induced / Q000453:epidemiology / Q000517:prevention & control*; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects; D051381:Rats
D016588:Anticarcinogenic Agents; D002273:Carcinogens; C014707:nitrosobenzylmethylamine; D004128:Dimethylnitrosamine; D005038:Ethylnitrosourea; D015119:Aminocaproic Acid
Tormoziashchee vliianie épsilon-aminokapronovoĭ kisloty na chastotu indutsirovannykh opukholeĭ pishchevoda, nervnoĭ sistemy i pochek.