title: Chordoma-natural history, treatment and prognosis. The Florence Radiotherapy Department experience (1956-1990) and a critical review of the literature.
abstract: Fifteen cases of chordoma, seen between 1956 and 1990 at the Florence Radiotherapy Department are reported. Twelve of them were treated with radiotherapy and surgery, while one was left untreated. We analyzed the course of the disease in the treated cases, with particular emphasis on the problem of symptom control. The natural history of the disease seemed to be only marginally affected by the treatment and new therapeutic options are strongly needed. While actuarial survival rates at 5 and 10 years were 58% and 35% respectively (owing to the slow growth rate of this neoplasm), 10 years' symptomatic progression-free, symptom-free, and disease-free survival rates were only 25%, 17% and 8% respectively.
authors.affiliation: Department of Radiotherapy, Florence, Italy.
authors.forename: S M
authors.initials: SM
authors.lastname: Magrini
authors.forename: M G
authors.initials: MG
authors.lastname: Papi
authors.forename: F
authors.initials: F
authors.lastname: Marletta
authors.forename: S
authors.initials: S
authors.lastname: Tomaselli
authors.forename: E
authors.initials: E
authors.lastname: Cellai
authors.forename: V
authors.initials: V
authors.lastname: Mungai
authors.forename: G
authors.initials: G
authors.lastname: Biti
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002817:Chordoma / Q000401:mortality / Q000532:radiotherapy / Q000601:surgery; D003131:Combined Modality Therapy; D004307:Dose-Response Relationship, Radiation; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D015996:Survival Rate