title: Heparin-associated thrombocytopenia: successful therapy with the heparinoid Org 10172 in a patient showing cross-reaction to LMW heparins.
abstract: A patient suffering from heparin-associated thrombocytopenia (HAT), recurrent arteriothromboses, and acute renal failure after treatment with standard heparin is described. He failed to improve when therapy was continued with low-molecular-weight (LMW) heparin (Fragmin, Kabi Pfrimmer, Erlangen, FRG). By means of the in vitro heparin-induced platelet activation (HIPA) assay it was shown that standard heparin and the LMW heparins Fragmin and Fraxiparin (Sanofi Labaz, Munich, FRG), as well as the enoxaparine Clexane (Nattermann, Cologne, FRG), all induced platelet activation with the patient's serum. In contrast, the LMW heparinoid Org 10172 (Organon, Oss, The Netherlands) did not cause platelet activation. When the patient was subsequently treated by parenteral administration of Org 10172 as anticoagulant over a period of several weeks the number of platelets rapidly increased and the patient almost completely recovered. This case shows that strong in vivo and in vitro cross-reactivity between standard heparin and LMW heparins may occur, but can be avoided by the use of a novel heparinoid, Org 10172. The HIPA assay provides a simple and sensitive laboratory method for the choice of an innocuous heparin or heparinoid for continued parenteral anticoagulation.
authors.affiliation: Institute of Clinical Immunology and Transfusion Medicine, University of Giessen, FRG.
authors.forename: A
authors.initials: A
authors.lastname: Greinacher
authors.forename: W
authors.initials: W
authors.lastname: Drost
authors.forename: I
authors.initials: I
authors.lastname: Michels
authors.forename: J
authors.initials: J
authors.lastname: Leitl
authors.forename: M
authors.initials: M
authors.lastname: Gottsmann
authors.forename: H J
authors.initials: HJ
authors.lastname: Kohl
authors.forename: M
authors.initials: M
authors.lastname: Glaser
authors.forename: C
authors.initials: C
authors.lastname: Mueller-Eckhardt
mesh_terms: D000368:Aged; D002809:Chondroitin Sulfates; D003429:Cross Reactions; D003871:Dermatan Sulfate; D005343:Fibrinolytic Agents / Q000627:therapeutic use; D006025:Glycosaminoglycans / Q000627:therapeutic use; D006493:Heparin / Q000009:adverse effects*; D006495:Heparin, Low-Molecular-Weight / Q000276:immunology; D006497:Heparan Sulfate; D006801:Humans; D008297:Male; D013921:Thrombocytopenia / Q000139:chemically induced / Q000188:drug therapy*
chemical_list: D002809:Chondroitin Sulfates; D003871:Dermatan Sulfate; D005343:Fibrinolytic Agents; D006025:Glycosaminoglycans; D006493:Heparin; D006495:Heparin, Low-Molecular-Weight; D006497:Heparan Sulfate; C035838:danaparoid