title: A molecular semiotic view of biology. Interferon and 'homeokine' as symbols.
abstract: A term "homeokine" was introduced as a generic name covering cytokines and protein hormones which serve the purpose of intercellular communication within the animal body for homeostasis and ontogenetic development. The homeokine system, in its complex way of functioning, seems to be analogous to another communication system, human language. Individual homeokine molecules are likened to words; they have meanings and are viewed as symbols, representing those conditions or events inside and outside the body which are relevant to homeostasis. Extending this view, any protein and other molecule can be considered to take on the character of sign, when integrated into a purposive system of higher hierarchy, because the molecule then represents a meaning relative to the system as a whole that is lacking in the isolated state. Living systems with their biological macromolecules as semantic units are constructed upon the principle of double articulation, just like human languages with words as the semantic units. The structure and function of a molecule (of protein and any other substance) are associated with each other, with various degrees of arbitrariness, as are the expression and the content of a sign in general. Namely the activities or the sign functions of biological molecules are determined by the organized system they belong to, and not vice versa.
authors.forename: Y
authors.initials: Y
authors.lastname: Kawade
mesh_terms: D002450:Cell Communication / Q000502:physiology*; D003142:Communication; D016207:Cytokines / Q000502:physiology; D006706:Homeostasis / Q000502:physiology*; D007372:Interferons / Q000502:physiology*; D007802:Language
chemical_list: D016207:Cytokines; D007372:Interferons