Russuphelin A, a new cytotoxic substance from the mushroom Russula subnigricans Hongo.
A new cytotoxic substance, designated russuphelin A (1), has been isolated from the mushroom Russula subnigricans Hongo (Basidiomycetes). The structure was elucidated as 2,6-bis(2,6-dichloro-4-hydroxyphenyloxy)-1,4-dimethoxy-benzene on the basis of spectroscopic data and confirmed by total synthesis.
Takahashi
A
A
Faculty of Pharmaceutical Sciences, Tohoku University, Sendai, Japan.
Agatsuma
T
T
Matsuda
M
M
Ohta
T
T
Nunozawa
T
T
Endo
T
T
Nozoe
S
S
D000818:Animals; D000840:Anisoles / Q000302:isolation & purification* / Q000633:toxicity; D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000302:isolation & purification* / Q000633:toxicity; D001487:Basidiomycota / Q000737:chemistry*; D002460:Cell Line; D002470:Cell Survival / Q000187:drug effects; D002733:Chlorophenols / Q000302:isolation & purification* / Q000633:toxicity; D003603:Cytotoxins / Q000138:chemical synthesis / Q000302:isolation & purification* / Q000633:toxicity; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D014407:Tumor Cells, Cultured
D000840:Anisoles; D000970:Antineoplastic Agents; D002733:Chlorophenols; D003603:Cytotoxins; C080188:russuphelin A