The role of lipoproteins in inactivation of endotoxin by serum.
Lipopolysaccharide (LPS)-induced release of cytokines from human monocytes can be prevented by previous interference of serum with LPS. This inactivation is a function of lipoproteins. Here we show that low-density lipoproteins as well as high-density lipoproteins can inactivate LPS. The effects of heparin and EDTA on LPS inactivation by serum are also described.
Northoff
H
H
DRK-Blutspendezentrale Ulm, FRG.
Flegel
W A
WA
Yurttas
R
R
Weinstock
C
C
D016207:Cytokines / Q000502:physiology; D004492:Edetic Acid / Q000494:pharmacology; D004731:Endotoxins / Q000037:antagonists & inhibitors / Q000097:blood*; D006493:Heparin / Q000494:pharmacology; D006801:Humans; D008070:Lipopolysaccharides / Q000037:antagonists & inhibitors / Q000097:blood; D008074:Lipoproteins / Q000502:physiology*
D016207:Cytokines; D004731:Endotoxins; D008070:Lipopolysaccharides; D008074:Lipoproteins; D006493:Heparin; D004492:Edetic Acid