[Toxicity of chongqing acid fogwater on rabbit alveolar macrophages in vitro].
We collected acid fogwater on a fogday and observed its toxic effects on rabbits' pulmonary alveolar macrophages (AM) in vitro. The fogwater was diluted into 4 concentrations: 1, 1/10, 1/100, and 1/1000 of the original fogwater and the exposure time was 12 hours. The results showed that both the AM's viability and the phagocytic capacity were depressed significantly, but the AM's lysosomal enzyme--acid phosphatase activity was found to be stimulated to increase. All these changes were directly correlated with the degree of pollution of the fogwater. Of these three toxicity indices, the most sensitive one was the change of AM's phagocytic capacity.
Shu
W Q
WQ
Department of Environmental Hygiene, 3rd Military Medical College, Chongqing.
Zhuo
J B
JB
D000135:Acid Phosphatase / Q000378:metabolism; D015258:Acid Rain / Q000633:toxicity*; D000397:Air Pollution / Q000009:adverse effects*; D000818:Animals; D002681:China; D016676:Macrophages, Alveolar / Q000187:drug effects*; D008297:Male; D010587:Phagocytosis / Q000187:drug effects*; D011817:Rabbits; D012905:Smog; D014877:Water Pollution, Chemical / Q000009:adverse effects*
D015258:Acid Rain; D012905:Smog; D000135:Acid Phosphatase