Neurotensin secretion in response to intraduodenal and intraileal administration of fat in dogs.
Release of neurotensin from the small intestine in response to administration of fat directly into the duodenum and ileum was examined in conscious dogs. The present results show that: (1) intraduodenal administration of fat causes a diphasic release of neurotensin which is mediated, at least in part, by cholinergic mechanisms, and (2) both a fatty acid (sodium oleate) and a triglyceride, when infused directly into an isolated ileal loop, stimulate a significant release of neurotensin. Our findings indicate that release of neurotensin is triggered by mechanisms originating in the proximal small intestine and by a direct contact of nutrients with the ileal mucosa.
Miyashita
T
T
Department of Surgery, University of Texas Medical Branch, Galveston 77555-0527.
Hashimoto
T
T
Gomez
G
G
Townsend
C M
CM
Greeley
G H
GH
Thompson
J C
JC
D000818:Animals; D002799:Cholinergic Fibers / Q000502:physiology; D004041:Dietary Fats / Q000008:administration & dosage*; D004285:Dogs; D004386:Duodenum / Q000294:innervation / Q000378:metabolism; D007082:Ileum / Q000294:innervation / Q000378:metabolism; D009496:Neurotensin / Q000378:metabolism*; D019301:Oleic Acid; D009829:Oleic Acids / Q000008:administration & dosage; D014280:Triglycerides / Q000008:administration & dosage
D004041:Dietary Fats; D009829:Oleic Acids; D014280:Triglycerides; D019301:Oleic Acid; D009496:Neurotensin; C013173:osteum