[Isoagglutinins after bone marrow transplantation with minor ABO incompatibility].
Sera of 22 patients after BMT with blood group change from A to 0 were investigated. Early after BMT 59% of the patients developed a temporary anti-A whereas late after BMT none of the patients tested showed isoagglutinins against A even though the red blood cells were of type 0 and anti-B was present. The onset of these anti-A isoagglutinins correlated with production of leukocytes by the donor BM and is regarded as a sign of GvHR. Late after BMT a permanent immunological tolerance to the A antigen of the recipients' old blood group seems to exist.
Wernet
D
D
Abteilung für Transfusionsmedizin mit Blutbank, Tübingen, BRD.
Mayer
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G
D000017:ABO Blood-Group System / Q000235:genetics*; D001787:Blood Group Incompatibility / Q000235:genetics / Q000276:immunology* / Q000401:mortality; D016026:Bone Marrow Transplantation / Q000276:immunology* / Q000401:mortality; D005500:Follow-Up Studies; D006086:Graft vs Host Disease / Q000235:genetics / Q000276:immunology / Q000401:mortality; D006461:Hemolysis / Q000276:immunology; D006650:Histocompatibility Testing; D006801:Humans; D007518:Isoantibodies / Q000032:analysis*; D012189:Retrospective Studies; D015996:Survival Rate
D000017:ABO Blood-Group System; D007518:Isoantibodies
Isoagglutinine nach Knochenmarktransplantation mit AB0-Minor-Inkompatibilität.