title: A multicenter study of the treatment of childhood chronic idiopathic thrombocytopenic purpura with anti-D.
abstract: We evaluated the effects of the intravenous administration of anti-D, an immune globulin directed at the D antigen on erythrocytes that is purified from plasma from sensitized persons, on patients with idiopathic thrombocytopenic purpura. To determine the most effective dose, the duration of response, and the side effects of this therapy in children, we performed a multicenter cohort study of escalating doses of intravenously administered anti-D in children aged 1 to 18 years with chronic idiopathic thrombocytopenic purpura, defined as idiopathic thrombocytopenic purpura persisting for more than 6 months with a platelet count of less than 50 x 10(9) cells/L. Twenty-five Rh-positive children received increasing doses of anti-D as follows: day 1, 25 micrograms/kg; day 2, 25 micrograms/kg; day 7, 35 micrograms/kg; day 14, 45 micrograms/kg; and day 21, 55 micrograms/kg. Administration of anti-D was stopped after day 21 or when the platelet count rose to greater than 150 x 10(9) cells/L or the hemoglobin level was 100 gm/L. Platelet count was less than 50 x 10(9) cells/L in all children before treatment. A response was defined as an increase in the platelet count to more than 50 x 10(9)/L and a doubling of the pretreatment platelet count. Of 25 children, 23 (92%) had responses by day 7 of the initial treatment protocol. Eighteen children (72%) had platelet counts greater than 150 x 10(9) cells/L by day 7 after two doses of anti-D. Median duration of response was 5 weeks (range 1 to 24 weeks). Average drop in hemoglobin level was 13.7 gm/L; in one child (a nonresponder) hemoglobin value fell to less than 100 gm/L. No other untoward side effects were seen. Of the 23 children who responded, 21 were retreated with one dose of anti-D when platelet counts returned to baseline values of less than 50 x 10(9) cells/L; all but three of the children who underwent retreatment showed a response the second time. Sixteen children continued to receive intermittent anti-D therapy after completion of the study, and all continued to have excellent responses. We conclude that anti-D is a safe, effective, and relatively inexpensive therapy for childhood chronic idiopathic thrombocytopenic purpura.
authors.affiliation: Department of Pediatrics, McMaster University Medical Center, Hamilton, Ontario, Canada.
authors.forename: M
authors.initials: M
authors.lastname: Andrew
authors.forename: V S
authors.initials: VS
authors.lastname: Blanchette
authors.forename: M
authors.initials: M
authors.lastname: Adams
authors.forename: K
authors.initials: K
authors.lastname: Ali
authors.forename: D
authors.initials: D
authors.lastname: Barnard
authors.forename: K W
authors.initials: KW
authors.lastname: Chan
authors.forename: L B
authors.initials: LB
authors.lastname: DeVeber
authors.forename: D
authors.initials: D
authors.lastname: Esseltine
authors.forename: S
authors.initials: S
authors.lastname: Israels
authors.forename: N
authors.initials: N
authors.lastname: Korbrinsky
mesh_terms: D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D003298:Coombs Test; D004334:Drug Administration Schedule; D005260:Female; D005500:Follow-Up Studies; D006454:Hemoglobins / Q000032:analysis; D006801:Humans; D007116:Immunization, Passive; D007136:Immunoglobulins; D007223:Infant; D007275:Injections, Intravenous; D007518:Isoantibodies / Q000627:therapeutic use*; D010976:Platelet Count / Q000187:drug effects; D016553:Purpura, Thrombocytopenic, Idiopathic / Q000097:blood / Q000628:therapy*; D018029:Rho(D) Immune Globulin; D016896:Treatment Outcome
chemical_list: D006454:Hemoglobins; D007136:Immunoglobulins; D007518:Isoantibodies; D018029:Rho(D) Immune Globulin