title: [Differences in the dynamics of the eosinophilia, blood immunoglobulin E and the level of circulating immune complexes in patients with chronic opisthorchiasis treated with different doses of praziquantel].
abstract: Sixty patients with a chronic Opisthorchis felineus infection were administered one-day therapy with praziquantel in doses 25, 40, or 60-75 mg/kg b. m. The former two doses of the drug did not much improve the levels of the examined immunologic parameters. In patients treated with the highest dose of praziquantel a significant decrease of the total and specific IgE and CIC levels, reaching that in the reference groups, was observed in 6-8 months after the treatment, this indicating a 92% efficacy of the drug in this group of patients.
authors.forename: Iu A
authors.initials: IuA
authors.lastname: Legon'kov
authors.forename: N N
authors.initials: NN
authors.lastname: Ozeretskovskaia
authors.forename: V B
authors.initials: VB
authors.lastname: Gervazieva
authors.forename: I G
authors.initials: IG
authors.lastname: Ovsiannikova
authors.forename: A M
authors.initials: AM
authors.lastname: Bronshteĭn
mesh_terms: D000293:Adolescent; D000328:Adult; D000936:Antigen-Antibody Complex / Q000097:blood*; D002908:Chronic Disease; D004802:Eosinophilia / Q000097:blood*; D005243:Feces / Q000469:parasitology; D005260:Female; D006801:Humans; D007073:Immunoglobulin E / Q000097:blood*; D008297:Male; D008875:Middle Aged; D009889:Opisthorchiasis / Q000097:blood* / Q000188:drug therapy / Q000276:immunology / Q000469:parasitology; D010270:Parasite Egg Count; D011223:Praziquantel / Q000008:administration & dosage*
chemical_list: D000936:Antigen-Antibody Complex; D007073:Immunoglobulin E; D011223:Praziquantel
vernacular_title: Razlichiia v dinamike éozinofilii krovi, immunoglobulinemii E i soderzhaniia tsirkuliruiushchikh immunnykh kompleksov u bol'nykh khronicheskim opistorkhozom, lechennykh raznymi dozami prazikvantelia.