title: Effect of hyperventilation on oxygenation of the brain cortex of neonates.
abstract: A new phosphorescence imaging method (Rumsey et al, Science (1988) 1649) has been used to continuously monitor the oxygen pressure in the blood of the cerebral cortex of newborn pigs. The animals' blood pressure was continuously measured and PaCO2, PaO2 and arterial blood pH were measured periodically. The oxygen pressure in the blood was quantitatively determined for regions of about 100 um square within the image (from a total field of about 3 mm diameter). It was observed that during hyperventilation, which lowered PaCO2 and increased pH of the blood, oxygen pressure decreased in proportion to the decrease in PaCO2. For example, hyperventilation which decreased PaCO2 from its normal value of 40 Torr to 10 Torr caused a rapid (within 5 minutes) decrease in oxygen pressure in the blood of capillaries and veins to approximately 1/4 of normal.
authors.affiliation: Department of Biochemistry and Biophysics, Medical School, University of Pennsylvania, Philadelphia 19104.
authors.forename: D F
authors.initials: DF
authors.lastname: Wilson
authors.forename: A
authors.initials: A
authors.lastname: Pastuszko
authors.forename: R
authors.initials: R
authors.lastname: Schneiderman
authors.forename: J E
authors.initials: JE
authors.lastname: DiGiacomo
authors.forename: M
authors.initials: M
authors.lastname: Pawlowski
authors.forename: M
authors.initials: M
authors.lastname: Delivoria-Papadopoulos
mesh_terms: D000818:Animals; D000831:Animals, Newborn; D002540:Cerebral Cortex / Q000378:metabolism*; D006985:Hyperventilation / Q000378:metabolism*; D016857:Hypocapnia / Q000378:metabolism; D007700:Kinetics; D008163:Luminescent Measurements; D015335:Molecular Probes; D010101:Oxygen Consumption; D013552:Swine
chemical_list: D015335:Molecular Probes