Role of free radicals in Plasmodium berghei infected Mastomys natalensis brain.
Lipid peroxide, lipid hydroperoxide, reduced glutathione, oxidised glutathione, lipofuscin contents and the activity of the enzyme superoxide dismutase were assessed in P. berghei infected M. natalensis brain. The results showed significant increase in the levels of lipid peroxides, lipid hydroperoxides and lipofuscin in brain subcellular fractions of P. berghei infected M. natalensis. Furthermore, a depressed superoxide dismutase activity was observed along with regulation in glutathione content. An elevated level of lipid peroxidation products along with depressed activity of scavengers in brain during malaria highlights the role of free radicals in malarial pathology.
Mahdi
A A
AA
Division of Biochemistry, Central Drug Research Institute, Lucknow, India.
Chander
R
R
Kapoor
N K
NK
Ahmad
S
S
D000818:Animals; D001921:Brain / Q000378:metabolism* / Q000469:parasitology / Q000473:pathology; D005609:Free Radicals / Q000378:metabolism; D005978:Glutathione / Q000378:metabolism*; D008054:Lipid Peroxides / Q000378:metabolism*; D008062:Lipofuscin / Q000378:metabolism; D008288:Malaria / Q000378:metabolism* / Q000473:pathology; D009115:Muridae; D010962:Plasmodium berghei; D013482:Superoxide Dismutase / Q000378:metabolism
D005609:Free Radicals; D008054:Lipid Peroxides; D008062:Lipofuscin; D013482:Superoxide Dismutase; D005978:Glutathione