title: Effects of fluoride and methanehydroxydiphosphate on enamel and on dentine demineralization.
abstract: The aim of this article was to investigate the effects of methanehydroxydiphosphonate (MHDP) and fluoride (F) separately and combined, on the demineralization process in enamel and in dentine under constant composition conditions. The demineralization was carried out in solutions containing 3 mM calcium, 3 mM phosphate, pH = 5.0, and either 6 microM MHDP, 12 microM F or 6 microM MHDP and 12 microM F. After demineralization periods (t) between 24 and 140 h, the lesion depth l and the mineral loss delta Z were measured by transverse microradiography of the enamel and dentine specimens. The amount of mineral lost during demineralization averaged over the lesion depth, R = delta Z/l, was calculated. R approximately 17 vol% for both enamel and dentine, both delta Z and l being greater for dentine than for enamel by approximately the same factor. The results show that under the same conditions dentine is attacked much more strongly than enamel. The lesion progress with time is quite different for the two tissues: in enamel the lesion depth progresses als l3 = alpha t + beta, in dentine as l2 = alpha't + beta'. The slopes alpha and alpha' decrease in the order MHDP > F > MHDP+F. In enamel the combined inhibitor effect is only slightly larger than the effect of F alone; in dentine the inhibiting effects of F and MHDP are approximately additive. The inhibitor interactions can be described by the Langmuir adsorption theory.(ABSTRACT TRUNCATED AT 250 WORDS)
authors.affiliation: Laboratory for Materia Technica, University of Groningen, The Netherlands.
authors.forename: J
authors.initials: J
authors.lastname: Arends
authors.forename: J
authors.initials: J
authors.lastname: Christoffersen
authors.forename: J A
authors.initials: JA
authors.lastname: Buskes
authors.forename: J
authors.initials: J
authors.lastname: Ruben
mesh_terms: D000085:Acetates / Q000494:pharmacology; D019342:Acetic Acid; D000818:Animals; D002122:Calcium Chloride / Q000494:pharmacology; D002327:Cariostatic Agents / Q000494:pharmacology; D002417:Cattle; D003743:Dental Enamel / Q000737:chemistry / Q000187:drug effects* / Q000473:pathology; D003804:Dentin / Q000737:chemistry / Q000187:drug effects* / Q000473:pathology; D004164:Diphosphonates / Q000494:pharmacology*; D005459:Fluorides / Q000494:pharmacology*; D008903:Minerals / Q000032:analysis; D010710:Phosphates / Q000494:pharmacology; D011188:Potassium / Q000494:pharmacology; D017680:Potassium Compounds; D013997:Time Factors; D017001:Tooth Demineralization / Q000378:metabolism / Q000473:pathology / Q000503:physiopathology*
chemical_list: D000085:Acetates; D002327:Cariostatic Agents; D004164:Diphosphonates; D008903:Minerals; D010710:Phosphates; D017680:Potassium Compounds; C029285:hydroxymethanediphosphonic acid; C013216:potassium phosphate; D002122:Calcium Chloride; D019342:Acetic Acid; D005459:Fluorides; D011188:Potassium