Neutrophil dysfunction in prepubertal periodontitis associated with Papillon-Lefèvre syndrome.
Although prepubertal periodontitis (PP) is often associated with the Papillon-Lefèvre (PLS), the etiopathogenetic mechanism in this disease has not been clarified as yet. A three and half year old female with leukocyte chemotaxis deficiency and decrease of T-lymphocytes is presented. The immunohistochemical evaluation of neutrophils showed a reduction of myeloperoxidase content, whereas ultrastructural studies revealed no particular change. The possible role of such a deficiency in the pathogenesis of the periodontal lesion is discussed.
D'Angelo
M
M
Department of Periodontology, University of Palermo.
Margiotta
V
V
Franco
V
V
Agate
V
V
D010520:Aggressive Periodontitis / Q000175:diagnosis* / Q000209:etiology; D002634:Chemotaxis, Leukocyte; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D007159:Immunologic Tests; D009000:Monocytes / Q000378:metabolism / Q000648:ultrastructure; D009504:Neutrophils / Q000378:metabolism* / Q000648:ultrastructure; D010214:Papillon-Lefevre Disease / Q000175:diagnosis* / Q000209:etiology