[Renal effects of the acute inhibition of angiotensin-converting enzyme. I. 3) Relative roles of angiotensin II and prostanoids in early hypokalemic dysfunction].
We have investigated the relative roles of some renal prostanoids and angiotensin II in the hypokalemic renal dysfunction. To this aim we have evaluated the renal function in healthy women in induced potassium depletion of moderate degree before and after acute inhibition of cyclooxygenase (indomethacin, I) or angiotensin converting enzyme (enalapril, E). The renal function was explored by clearance (cl.) method during hypotonic polyuria induced by oral water load followed by 5% dextrose solution infusion; the urinary PGE2, 6-keto-PGF1 alpha and TxB2 were determined by RIA method. Potassium depletion was induced in 12 subjects by adaptation to low potassium (< or = 10 mmol/d) and normal sodium (150 mmol/d) dietary intake combined to natriuretic treatment. The water and NaCl net losses were restored by 0.9% NaCl solution infusion. In 6 subjects paired functional studies were performed in absence (D3) and presence of I (D3.I), 100 mg administered i.m. immediately before the water load. In other 6 subjects, paired studies were performed in absence (D4) and presence of E (D4.E), 10 mg administered per os 1 hour before the water load. No significant difference between D3 and D4 was observed as regards the potassium cumulative deficit as well as the basal values of plasma potassium concentration and plasma renin activity.(ABSTRACT TRUNCATED AT 250 WORDS)
Agnoli
G C
GC
Cattedra di Medicina Interna I, Università di Bologna.
Borgatti
R
R
Cacciari
M
M
Ikonomu
E
E
Lenzi
P
P
Marinelli
M
M
Martello
M
M
D000804:Angiotensin II / Q000502:physiology*; D001794:Blood Pressure / Q000187:drug effects; D002712:Chlorides / Q000652:urine; D003404:Creatinine / Q000378:metabolism; D004231:Diuresis / Q000187:drug effects; D004656:Enalapril / Q000494:pharmacology*; D005260:Female; D006801:Humans; D007008:Hypokalemia / Q000209:etiology / Q000503:physiopathology*; D007213:Indomethacin / Q000494:pharmacology; D007668:Kidney / Q000187:drug effects* / Q000503:physiopathology; D011191:Potassium Deficiency / Q000150:complications / Q000503:physiopathology; D011453:Prostaglandins / Q000502:physiology*; D012083:Renin / Q000097:blood; D012084:Renin-Angiotensin System / Q000502:physiology; D014883:Water-Electrolyte Imbalance / Q000503:physiopathology
D002712:Chlorides; D011453:Prostaglandins; D000804:Angiotensin II; D004656:Enalapril; D003404:Creatinine; D012083:Renin; D007213:Indomethacin
Effetti renali della inibizione acuta dell'enzima convertente l'angiotensina. I. 3). Ruoli relativi dell'angiotensina II e dei prostanoidi nella difunzione ipokaliemica precoce.