title: [Surgical pathology of the aortic valve: a morphologic study on 912 surgically excised valves].
abstract: A consecutive series of 912 surgically excised aortic valves was evaluated by means of macroscopic and histologic study. Pure aortic stenosis was diagnosed in 203 patients (p.) (22.25%), pure incompetence in 125 (13.72%) and combined dysfunction in 584 (64.03%). The diseases affecting the valves were: a) chronic rheumatic disease (593 p., 65%); b) dystrophic calcifications (214 p., 23%); c) noninflammatory aortic root disease (NIARD) and/or myxomatous infiltration of aortic cusps, floppy aortic valve (FAV) (55 p., 6%) d) infective endocarditis (50 p., 5.5%). Males outnumbered females with a ratio ranging from 2.4 (dystrophic calcific disease) to 1.6 (infective endocarditis). The mean age ranged from 37 +/- 7.5 (NIARD) to 61.2 +/- 6.3 (dystrophic calcific disease). Chronic rheumatic disease was the most frequent cause of stenoincompetence (542 p., 91.4%) while isolated stenosis was prevalently due to dystrophic calcification (172 p., 80.4%). The diseases causing isolated aortic incompetence were (in order of frequency): a) NIARD and/or FAV (55 p., 44%); b) infective endocarditis (50 p., 40%); and c) rheumatic disease (30 p., 16%). The 55 patients with NIARD and or FAV were divided into 3 groups: a) 23 p. with aortic root dilatation and normal cusps; b) 20 p. with aortic root dilatation and FAV; c) 12 p. with FAV but undilated aortic root. Aortic regurgitation was caused by cusp derangement in rheumatic disease (shortening, retraction) and infective endocarditis (perforations, erosions). Cusps diastasis and prolapse were the cause of regurgitation in aortic root dilatation.(ABSTRACT TRUNCATED AT 250 WORDS)
authors.affiliation: Istituto di Anatomia Patologica, Prima Facoltà di Medicina, Università Federico II di Napoli.
authors.forename: L
authors.initials: L
authors.lastname: Agozzino
authors.forename: A
authors.initials: A
authors.lastname: Falco
authors.forename: L
authors.initials: L
authors.lastname: De Luca Tupputi Schinosa
authors.forename: F
authors.initials: F
authors.lastname: De Vivo
authors.forename: S
authors.initials: S
authors.lastname: Esposito
authors.forename: M
authors.initials: M
authors.lastname: Cotrufo
mesh_terms: D000328:Adult; D001021:Aortic Valve / Q000473:pathology* / Q000601:surgery; D001022:Aortic Valve Insufficiency / Q000209:etiology / Q000473:pathology; D002114:Calcinosis / Q000150:complications / Q000473:pathology; D004697:Endocarditis, Bacterial / Q000150:complications / Q000473:pathology; D005260:Female; D006349:Heart Valve Diseases / Q000209:etiology / Q000473:pathology / Q000601:surgery; D006801:Humans; D008297:Male; D012214:Rheumatic Heart Disease / Q000150:complications / Q000473:pathology
vernacular_title: "Surgical pathology" della valvola aortica: studio morfologico su 912 espianti chirurgici.