Brain histamine: psychoneuroimmune regulator in physiological and pathological conditions.
HA is a biogenic amine widely distributed in the CNS, with neurons located in the posterior hypothalamus. HA acts as a neurotransmitter and/or neuromodulator regulating neuroendocrine and neuroimmune functions, circadian rhythms, sleep-wakefulness cycle, body temperature, centrally-mediated neurovegetative functions, cerebrovascular control, and behavior and learning. Changes in brain HA are observed in aging. High levels of HA in CSF and CNS of AD patients might reflect a reactive response to neuroimmune activation and tissue damage.
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Department of Human Physiology, Complutense University Medical School, Madrid, Spain.
D000375:Aging / Q000502:physiology*; D000544:Alzheimer Disease / Q000503:physiopathology*; D000818:Animals; D001921:Brain / Q000502:physiology*; D015140:Dementia, Vascular / Q000503:physiopathology*; D006632:Histamine / Q000502:physiology*; D006801:Humans; D007858:Learning / Q000502:physiology; D008568:Memory / Q000502:physiology; D015213:Neuroimmunomodulation / Q000502:physiology*; D009490:Neurosecretory Systems / Q000502:physiology
D006632:Histamine