Genetic polymorphism of complement component C6, C7 and C8(1) in Chinese Han population in northeast China.
Distributions of complement phenotypes, C6, C7, and C8(1) were studied using thin agarose gel isoelectric focusing (AGIEF) or ultra-thin polyacrylamide gel isoelectric focusing (PAGIEF) and subsequent immunoblotting techniques in 203 Chinese Han population in Liaoning Province of northeast China. The gene frequencies were as follows: C6*A 0.4704, C6*B 0.5049, C6*B2 0.0148, C6*B3 0.0049, and C6*M 0.0049; C7*1 0.8251, C7*2 0.1108, C7*3 0.0320, and C7*4 0.0320; C8(1)*A 0.5567 and C8(1)B 0.4433, respectively. All the observed numbers of the phenotypes were in agreement with the expected numbers under the Hardy-Weinberg equilibrium. The gene frequencies among Chinese subpopulations and other various populations were compared.
Tsunenari
S
S
Department of Forensic Medicine, Kumamoto University School of Medicine, Japan.
Kibayashi
K
K
Higashi
T
T
Pang
H
H
Ding
M
M
Jia
J
J
D044466:Asian People; D002681:China; D003183:Complement C6 / Q000235:genetics*; D003184:Complement C7 / Q000235:genetics*; D003185:Complement C8 / Q000235:genetics*; D005006:Ethnicity; D005787:Gene Frequency; D006801:Humans; D015151:Immunoblotting; D007525:Isoelectric Focusing; D010641:Phenotype; D011110:Polymorphism, Genetic
D003183:Complement C6; D003184:Complement C7; D003185:Complement C8