[Emoxipin as an inhibitor of angiogenesis].
The effect of emoxypin on angiogenesis in rabbit cornea in aseptic inflammation induced by intracorneal implantation of a piece of quartz and on the development of the vessels of the chick embryo yolk sac was studied. 1% emoxypin pipetted thrice a day for 10-14 days inhibited corneal neovascularization and reduced the formation of new blood vessels. We observed an inhibitory effect on the development of vascular bed of the embryo yolk sac on incubation hour 64-72. The drug affected neither general growth of the embryos no the number of somites.
Sologub
A A
AA
Akberova
S I
SI
Ziangirova
G G
GG
D000818:Animals; D000975:Antioxidants / Q000494:pharmacology* / Q000627:therapeutic use; D002642:Chick Embryo; D002908:Chronic Disease; D003315:Cornea / Q000098:blood supply / Q000187:drug effects; D003864:Depression, Chemical; D004353:Drug Evaluation, Preclinical; D005451:Fluorescein Angiography; D007634:Keratitis / Q000188:drug therapy / Q000209:etiology; D009389:Neovascularization, Pathologic / Q000517:prevention & control*; D010847:Picolines / Q000494:pharmacology* / Q000627:therapeutic use; D011817:Rabbits; D013997:Time Factors; D015017:Yolk Sac / Q000098:blood supply / Q000187:drug effects
D000975:Antioxidants; D010847:Picolines; C009820:6-methyl-2-ethyl-3-hydroxypyridine
Emoksipin kak ingibitor angiogeneza.