title: Noncytotoxic drug therapy for intra-abdominal desmoid tumor in patients with familial adenomatous polyposis.
abstract: Forty of 416 patients with familial adenomatous polyposis were noted to have intra-abdominal desmoid tumors, and a subgroup of 16 were treated with noncytotoxic drug therapy. Drugs used were sulindac (14 patients), sulindac plus tamoxifen (3 patients), indomethacin (4 patients), tamoxifen (4 patients), progesterone (DEPO-PROVERA; Upjohn Co., Kalamazoo, MI) (2 patients), and testolactone (1 patient). Therapy with these drugs for continuous periods of six months or more resulted in three complete and seven partial remissions. When treated patients were compared with untreated patients (n = 12), there were significant benefits for the treated group, both in reduction of desmoid size and in improvement of symptoms, despite the inherent selection bias against this. Sulindac was the only drug used in enough patients to permit independent evaluation of its effect, with one complete and seven partial reductions of tumor size. Some patients had a delayed response to sulindac, with tumor shrinkage occurring after an initial period of tumor enlargement. When using sulindac for the treatment of desmoid tumors, this phenomenon should be considered.
authors.affiliation: Department of Colorectal Surgery, Cleveland Clinic Foundation, Ohio 44195.
authors.forename: K
authors.initials: K
authors.lastname: Tsukada
authors.forename: J M
authors.initials: JM
authors.lastname: Church
authors.forename: D G
authors.initials: DG
authors.lastname: Jagelman
authors.forename: V W
authors.initials: VW
authors.lastname: Fazio
authors.forename: E
authors.initials: E
authors.lastname: McGannon
authors.forename: C R
authors.initials: CR
authors.lastname: George
authors.forename: T
authors.initials: T
authors.lastname: Schroeder
authors.forename: I
authors.initials: I
authors.lastname: Lavery
authors.forename: J
authors.initials: J
authors.lastname: Oakley
mesh_terms: D000008:Abdominal Neoplasms / Q000188:drug therapy* / Q000473:pathology / Q000503:physiopathology; D011125:Adenomatous Polyposis Coli; D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D005260:Female; D005350:Fibroma / Q000188:drug therapy* / Q000473:pathology / Q000503:physiopathology; D006801:Humans; D008297:Male; D009378:Neoplasms, Multiple Primary / Q000188:drug therapy*; D010146:Pain / Q000209:etiology / Q000517:prevention & control; D012074:Remission Induction; D012189:Retrospective Studies; D013467:Sulindac / Q000008:administration & dosage / Q000009:adverse effects
chemical_list: D013467:Sulindac