title: Cerebral blood flow and cerebral oxygen consumption in patients with COPD on mechanical ventilation.
abstract: OBJECTIVE
  To investigate the effect of PaCO2 on cerebral blood flow (CBF) in chronic obstructive pulmonary disease (COPD).
  
  
  METHODS
  Before-after trial.
  
  
  METHODS
  General ICU in a regional hospital.
  
  
  METHODS
  7 patients undergoing mechanical ventilation because of an exacerbation of COPD.
  
  
  METHODS
  CBF and cerebral metabolic rate of oxygen (CMRO2) of COPD were measured before and after hyperventilation and were compared by those of normal patients. CBF was measured by the Kety-Schmidt technique using 15% N2O.
  
  
  RESULTS
  Hyperventilation produced a significant reduction in CBF in COPD with no concomitant change in CMRO2. CMRO2 in COPD was significantly lower than those in normal patients. The regression equation was shifted significantly more to the right in COPD.
  
  
  CONCLUSIONS
  The sensitivity of CBF in CO2 remained but CMRO2 was reduced markedly in COPD patients.
authors.affiliation: Department of Anesthesia, Kurashiki Central Hospital, Okayama, Japan.
authors.forename: A
authors.initials: A
authors.lastname: Sari
authors.forename: S
authors.initials: S
authors.lastname: Oshiata
authors.forename: T
authors.initials: T
authors.lastname: Toriumi
authors.forename: S
authors.initials: S
authors.lastname: Yamashita
authors.forename: S
authors.initials: S
authors.lastname: Kojima
authors.forename: S
authors.initials: S
authors.lastname: Kakumoto
authors.forename: A
authors.initials: A
authors.lastname: Yonei
mesh_terms: D000328:Adult; D000368:Aged; D000403:Airway Resistance; D001783:Blood Flow Velocity; D001784:Blood Gas Analysis; D001921:Brain / Q000378:metabolism*; D002245:Carbon Dioxide / Q000097:blood; D002560:Cerebrovascular Circulation; D005069:Evaluation Studies as Topic; D006439:Hemodynamics; D006801:Humans; D016014:Linear Models; D008173:Lung Diseases, Obstructive / Q000378:metabolism / Q000503:physiopathology / Q000628:therapy*; D008297:Male; D008875:Middle Aged; D009609:Nitrous Oxide; D010101:Oxygen Consumption; D012121:Respiration, Artificial / Q000379:methods / Q000592:standards*; D016896:Treatment Outcome
chemical_list: D002245:Carbon Dioxide; D009609:Nitrous Oxide