[The normalizing effect of dalargin on the glucocorticoid and opioid levels of the blood in CBA and C57Bl/6 mice undergoing footshock stress].
Radioreceptor investigations showed that it is impossible to interpret changes in the activity of opioid receptor ligands of mu and delta types in plasma of mice under footshock stress (FSS) as activation or depletion of opioid system (OS). There occurred qualitative changes characterized by interstrain differences (ID). These are also typical for dynamics of development of FSS effects on blood corticosterone levels. Administration of dalargin diminishes qualitative and quantitative changes in OS function at different periods after FSS preventing early rise of corticosterone levels after the exposure. In spite of common features in dalargin action on opioid and steroid metabolism in mice of both strains, ID are also present.
Shchurin
M R
MR
Pshenichkin
S F
SF
Solov'eva
M S
MS
Smirnova
G V
GV
Goncharov
N P
NP
Mit'kin
V V
VV
Sukhikh
G T
GT
Lavrov
V F
VF
Kirillicheva
G B
GB
Zozulia
A A
AA
D000818:Animals; D004353:Drug Evaluation, Preclinical; D004597:Electroshock; D004723:Endorphins / Q000097:blood*; D016308:Enkephalin, Leucine-2-Alanine / Q000031:analogs & derivatives* / Q000627:therapeutic use; D005528:Foot; D005938:Glucocorticoids / Q000097:blood*; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL / Q000097:blood*; D008808:Mice, Inbred CBA / Q000097:blood*; D011869:Radioligand Assay; D013045:Species Specificity; D013312:Stress, Physiological / Q000097:blood / Q000188:drug therapy* / Q000209:etiology; D013997:Time Factors
D004723:Endorphins; D005938:Glucocorticoids; D016308:Enkephalin, Leucine-2-Alanine; C040996:enkephalin-Leu, Ala(2)-Arg(6)-
Normalizuiushchee vliianie dalargina na uroven' gliukokortikoidov i opioidov v krovi mysheĭ liniĭ CBA i C57Bl/6 v usloviiakh footshock-stressa.