Chemical cleavage of plasmid DNA by Cu(II), Ni(II) and Co(III) desferal complexes.
It is demonstrated that the Cu(II), Co(III) and Ni(II) complexes of a siderophore chelating drug desferal cleave DNA, in contrast to the corresponding Fe(II) complex which does not bring about DNA scission. Hydroxy radical scavengers inhibit the cleavage reaction.
Joshi
R R
RR
Biorganic Chemistry Unit, National Chemical Laboratory, Poona, India.
Ganesh
K N
KN
D003035:Cobalt; D003300:Copper; D004269:DNA, Bacterial; D003676:Deferoxamine; D016166:Free Radical Scavengers; D005609:Free Radicals; D006868:Hydrolysis; D006878:Hydroxides; D017665:Hydroxyl Radical; D009532:Nickel; D010957:Plasmids
D004269:DNA, Bacterial; D016166:Free Radical Scavengers; D005609:Free Radicals; D006878:Hydroxides; D017665:Hydroxyl Radical; D003035:Cobalt; D003300:Copper; D009532:Nickel; D003676:Deferoxamine