[The possible mechanisms of the interaction of hepatotropic diagnostic agents with proteins].
The phenomenon of precipitation in protein solutions after addition of hepatotropic diagnostic media is described. The examination of different proteins and media allows the coagulative mechanism to be proposed, through which the electrostatic interactions between di- and polyvalent ligands with positively charged protein groups play the major role. It is suggested that the described phenomenon contributes to the nephrotoxicity of some drug groups.
Zaretskiĭ
D V
DV
Troianovskaia
L B
LB
Garin
V R
VR
D000818:Animals; D002417:Cattle; D011232:Chemical Precipitation; D003974:Diatrizoate Meglumine / Q000494:pharmacology; D004347:Drug Interactions; D006454:Hemoglobins / Q000187:drug effects* / Q000378:metabolism; D006801:Humans; D006863:Hydrogen-Ion Concentration; D066298:In Vitro Techniques; D007451:Iodamide / Q000494:pharmacology; D007458:Iodipamide / Q000494:pharmacology; D008099:Liver / Q000187:drug effects*; D011479:Protamines / Q000494:pharmacology; D011485:Protein Binding / Q000187:drug effects; D051381:Rats; D012709:Serum Albumin / Q000187:drug effects* / Q000378:metabolism; D012710:Serum Albumin, Bovine / Q000187:drug effects* / Q000378:metabolism; D013448:Sulfobromophthalein / Q000494:pharmacology
D006454:Hemoglobins; D011479:Protamines; D012709:Serum Albumin; D013448:Sulfobromophthalein; D012710:Serum Albumin, Bovine; D003974:Diatrizoate Meglumine; D007451:Iodamide; D007458:Iodipamide
Vozmozhnye mekhanizmy vzaimodeĭstviia gepatotropnykh diagnosticheskikh sredstv s belkami.