title: Inhibitory effect of oligosaccharides derived from plant xyloglucan on intestinal glucose absorption in rat.
abstract: We studied the effects of oligosaccharides which were obtained from tamarind xyloglucan by cellulase digestion on absorption of 3-O-methyl-D-glucose using the everted sacs from rat small intestine. Among oligosaccharides tested, octasaccharide and nonasaccharide, which contain D-galactose residue at non-reducing terminals, inhibited effectively absorption of 3-O-methyl-D-glucose, and their inhibitory effects were concentration-dependent. On the other hand, heptasaccharide not having D-galactose residue at its non-reducing terminal showed no inhibitory effect on absorption of 3-O-methyl-D-glucose. These results indicate that the octasaccharide and nonasaccharide may not only serve as a soluble dietary fiber with small molecular weight but also lower the blood sugar level.
authors.affiliation: Department of Food and Nutrition, Faculty of Science of Living, Osaka City University, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Sone
authors.forename: C
authors.initials: C
authors.lastname: Makino
authors.forename: A
authors.initials: A
authors.lastname: Misaki
mesh_terms: D019325:3-O-Methylglucose; D000818:Animals; D005936:Glucans; D066298:In Vitro Techniques; D007408:Intestinal Absorption / Q000187:drug effects*; D007421:Intestine, Small / Q000187:drug effects; D008297:Male; D008757:Methylglucosides / Q000493:pharmacokinetics*; D009844:Oligosaccharides / Q000302:isolation & purification / Q000494:pharmacology*; D010936:Plant Extracts / Q000737:chemistry*; D011134:Polysaccharides / Q000737:chemistry*; D051381:Rats; D017208:Rats, Wistar; D014990:Xylans
chemical_list: D005936:Glucans; D008757:Methylglucosides; D009844:Oligosaccharides; D010936:Plant Extracts; D011134:Polysaccharides; D014990:Xylans; D019325:3-O-Methylglucose; C029353:xyloglucan