[The effect of ziksorin on the development of experimental food anaphylaxis in guinea pigs].
A study was made of the effect of zixorin, an inductor of liver cytochrome P-450, on the intensity of the immediate type allergic reaction--active food anaphylaxis in response to ovalbumin in guinea-pigs. Intraperitoneal injection of zixorin in a dose of 50 mg/kh for 3 days before administration of the antigen resolution dose was found to lower 2,3-fold the level of lethal outcomes due to the anaphylactic shock. It is suggested that zixorin may be used in multimodality treatment of food allergy.
Khlopushina
T G
TG
Krinskaia
A V
AV
Kovalenko
L P
LP
Liubimov
B I
BI
D000276:Adjuvants, Immunologic / Q000627:therapeutic use*; D000707:Anaphylaxis / Q000209:etiology / Q000517:prevention & control*; D000818:Animals; D001559:Benzhydryl Compounds / Q000627:therapeutic use*; D003577:Cytochrome P-450 Enzyme System / Q000096:biosynthesis / Q000187:drug effects; D004353:Drug Evaluation, Preclinical; D004527:Egg Proteins / Q000009:adverse effects*; D004790:Enzyme Induction / Q000187:drug effects; D005512:Food Hypersensitivity / Q000209:etiology / Q000517:prevention & control*; D006168:Guinea Pigs; D006969:Hypersensitivity, Immediate / Q000209:etiology / Q000517:prevention & control; D007114:Immunization; D008297:Male
D000276:Adjuvants, Immunologic; D001559:Benzhydryl Compounds; D004527:Egg Proteins; D003577:Cytochrome P-450 Enzyme System; C016914:flumecinol
Vliianie ziksorina na razvitie éksperimental'noĭ pishchevoĭ anafilaksii u morskikh svinok.