[Evaluation of an immunoenzymatic assay for determining estrogen and progesterone receptors in breast tumors].
The aim of our research was the usability of immunoenzymatic assay for the determination of estrogen and progesterone receptors. We tested 59 women with breast tumours. 20 of these women have had carcinoma ductal, 10 carcinoma lobular and 3 women another histopathological type. 26 women have had benign tumours: 15 mastopathia fibrosocystica, 11 fibroadenoma. It was found that mean concentration of cER, nER and cPgR, nPgR were higher in malignant tumours as compared with benign tumours. Mean concentration of cER in carcinoma ductale (mean = 45.96 fmol/mg protein) and carcinoma lobular (mean = 130.38 fmol/mg protein) were of higher statistical significance than the levels of these receptors in mastopathia fibroso-cystica (mean = 16.82 fmol/mg protein). Mean concentrations nER and nPgR in benign and malignant tumours were not statistically significant. On the basis of our own investigations we can suggest that immunoenzymatic method supplied by Abbott is a simple test to perform and useful to evaluate hormonal dependence of cancer tissue.
Kopczyński
Z
Z
Zakładu Analityki Medycznej i Oddziału Chirurgii Katedry Onkologii Akademii Medycznej im. Karola Marcinkowskiego, Poznaniu.
Stachowicz
A
A
Kociałkowski
K
K
Grodecka-Gazdecka
S
S
Faryńska
E
E
D014408:Biomarkers, Tumor / Q000032:analysis*; D001943:Breast Neoplasms / Q000737:chemistry* / Q000473:pathology; D005260:Female; D006801:Humans; D007124:Immunoenzyme Techniques; D011960:Receptors, Estrogen / Q000032:analysis*; D011980:Receptors, Progesterone / Q000032:analysis*
D014408:Biomarkers, Tumor; D011960:Receptors, Estrogen; D011980:Receptors, Progesterone
Ocena metody immunoenzymatycznej do oznaczania receptorów estrogenowych (ER) i progesteronowych (PgR) w guzach sutka.