title: [Chorea associated with antiphospholipid antibodies].
abstract: We report a 21-year-old woman in whom chorea was associated with antiphospholipid antibodies. In August 1986, she developed involuntary movement which started in the right hand but subsided spontaneously. In September 1988, she again developed right-sided involuntary movements which started in the right hand but rapidly progressed to involve the whole of the right side. In September 1990, she was admitted to our hospital for investigation of choreiform movements, because her involuntary movements had progressed to involve all four extremities. She had no family or past history of chorea, psychiatric, rheumatological or vascular disease. On admission, she had difficulty in speaking and swallowing due to choreiform movements of her mouth and tongue. Her gait was unsteady. On walking she had wild gyrations of the arms. Choreiform movements of all four extremities, neck, face, mouth and tongue were present at rest, more marked on the right side. There was no other neurological deficits. She had none of the classical features of SLE. She had none of the complications commonly associated with antiphospholipid antibody syndrome (APS) (i.e., recurrent spontaneous abortion, thrombosis and thrombocytopenia). Laboratory tests revealed that antinuclear antibody was present. Cardiolipin antibody (VDRL) was positive but specific tests for syphilis were negative. Anticardiolipin antibodies were present. All coagulation studies have failed to reveal lupus anticoagulant. Brain CT, MRI, 123IMP-SPECT and cerebral angiography were normal. Associated with her chorea, she had the serological but not the clinical features of APS. We suggest that antiphospholipid antibodies should be looked for in all unexplained cases of chorea, even when the associated clinical signs of APS are absent.
authors.affiliation: Department of Neurology, Iwate Prefectural Central Hospital.
authors.forename: T
authors.initials: T
authors.lastname: Shimomura
authors.forename: S
authors.initials: S
authors.lastname: Takahashi
authors.forename: S
authors.initials: S
authors.lastname: Takahashi
mesh_terms: D000328:Adult; D017153:Antibodies, Anticardiolipin / Q000032:analysis*; D000974:Antibodies, Antinuclear / Q000032:analysis; D016736:Antiphospholipid Syndrome / Q000150:complications* / Q000175:diagnosis; D002819:Chorea / Q000209:etiology*; D005260:Female; D006801:Humans
chemical_list: D017153:Antibodies, Anticardiolipin; D000974:Antibodies, Antinuclear