The association of germ cell tumours of the testis with sarcoid-like processes.
Sarcoid-type pulmonary lymphadenopathy associated with testicular cancer is a rare condition which has been previously reported in only 14 cases. Earlier case reports have failed to distinguish between generalized sarcoidosis as opposed to a local granulomatous reaction to tumour. We describe a further 8 cases of the association and provide strong supportive evidence for systemic sarcoidosis in 5 of our patients. In 3 of our patients with systemic sarcoidosis there was coexisting testicular cancer requiring additional treatment. We therefore advise caution in the interpretation of the clinical and histological findings in these patients, and recommend thorough investigation of all such cases.
Leatham
E W
EW
Royal Marsden Hospital, London, UK.
Eeles
R
R
Sheppard
M
M
Moskovic
E
E
Williams
M P
MP
Horwich
A
A
Mitchell
D N
DN
D000328:Adult; D003131:Combined Modality Therapy; D004407:Dysgerminoma / Q000175:diagnosis / Q000473:pathology / Q000628:therapy; D006801:Humans; D008175:Lung Neoplasms / Q000556:secondary; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D009373:Neoplasms, Germ Cell and Embryonal / Q000175:diagnosis* / Q000473:pathology / Q000628:therapy; D009919:Orchiectomy; D012507:Sarcoidosis / Q000175:diagnosis* / Q000473:pathology / Q000628:therapy; D013724:Teratoma / Q000175:diagnosis / Q000473:pathology / Q000628:therapy; D013733:Testicular Diseases / Q000175:diagnosis* / Q000473:pathology / Q000628:therapy; D013736:Testicular Neoplasms / Q000175:diagnosis* / Q000473:pathology / Q000628:therapy