[The effect of glycosaminoglycans in the pulmonary interstitial fibrosis development].
The pulmonary interstitial fibrosis was caused by injecting Bleomycin into mouse trachea. After the injection, the volume of glycosaminoglycans (GAG) in bronchoalveolar lavage fluid and lung tissues was increased. The observation of histochemical stain and electron microscope showed that the distribution of GAG in lung tissues was varied at different time after the injection, and related to the volume of collagen proteins and the formation of pulmonary interstitial fibrosis.
Li
B Y
BY
Department of pathology, Jilin Medical College.
D000818:Animals; D001761:Bleomycin; D001992:Bronchoalveolar Lavage Fluid / Q000378:metabolism*; D003094:Collagen / Q000378:metabolism; D005260:Female; D006025:Glycosaminoglycans / Q000378:metabolism*; D008168:Lung / Q000378:metabolism; D051379:Mice; D008810:Mice, Inbred C57BL; D011658:Pulmonary Fibrosis / Q000139:chemically induced / Q000378:metabolism*; D013997:Time Factors
D006025:Glycosaminoglycans; D001761:Bleomycin; D003094:Collagen