[Preventive effect of domestic, synthetic beta-carotene on the development of rat mammary tumors induced by DMBA].
Preventive effects of artificial beta-carotene on the development of rat mammary gland adenocarcinomas induced by DMBA were studied in rats maintained on a diet containing beta-carotene at a dose of 2.5 mg per animal within 10 weeks, which was initiated after the carcinogen administration. The carotenoid treatment course caused the following effects: manifestation of adenocarcinomas induced by DMBA was decreased, latent period of neoplasm development as well as the rate of tumor differentiation were increased and metastatic spreading into the regional lymph nodes was inhibited.
Sergeeva
T I
TI
Khaetskiĭ
I K
IK
Polishchuk
A S
AS
Khaetskaia
V I
VI
Vakulova
L A
LA
Zhidkova
T A
TA
D015127:9,10-Dimethyl-1,2-benzanthracene; D000818:Animals; D002338:Carotenoids / Q000627:therapeutic use*; D008207:Lymphatic Metastasis; D008325:Mammary Neoplasms, Experimental / Q000139:chemically induced / Q000473:pathology / Q000517:prevention & control*; D051381:Rats; D019207:beta Carotene
D019207:beta Carotene; D002338:Carotenoids; D015127:9,10-Dimethyl-1,2-benzanthracene
Prevenivnoe deĭstvie otechestvennogo sinteticheskogo beta-karotina na razvitie indutsirovannykh DMBA opukholeĭ molochnoĭ zhelezy krys.