title: Haemodynamic responses to tracheal intubation following etomidate and fentanyl for anaesthetic induction.
abstract: The haemodynamic response to anaesthetic induction and tracheal intubation was studied in 29 patients undergoing elective myocardial revascularization surgery. All patients included in the study were anaesthetized with etomidate, 0.3 mg.kg-1. The patients were randomized to three groups: Group I received fentanyl, 2.5 micrograms.kg-1; Group II received fentanyl, 5 micrograms.kg-1; and Group III received fentanyl, 10 micrograms.kg-1. Haemodynamic variables were measured at baseline (awake), after anaesthetic induction, and at one, three, five, and ten minutes after tracheal intubation. The number of patients with haemodynamic responses to intubation (> 20% increase in heart rate or mean arterial pressure) was greater (P < 0.05) in Group I than in Groups II and III. Statistically significant, but clinically minor, decreases in mean arterial pressure and cardiac output occurred in all groups at the last three study times. The frequency of involuntary muscle movements was 14%, and all of these events occurred in patients in Group I. In conclusion, the authors recommend using fentanyl, 5-10 micrograms.kg-1 to blunt the haemodynamic response to tracheal intubation following anaesthetic induction with etomidate, 0.3 mg.kg-1.
authors.affiliation: Department of Anesthesiology, Mount Sinai Medical Center, New York, NY 10029-6574.
authors.forename: L J
authors.initials: LJ
authors.lastname: Weiss-Bloom
authors.forename: D L
authors.initials: DL
authors.lastname: Reich
mesh_terms: D000368:Aged; D000771:Anesthesia, Intravenous; D016280:Atrial Function, Right / Q000187:drug effects; D001794:Blood Pressure / Q000187:drug effects; D002302:Cardiac Output / Q000187:drug effects; D002306:Cardiac Volume / Q000187:drug effects; D004311:Double-Blind Method; D005045:Etomidate / Q000008:administration & dosage* / Q000494:pharmacology; D005260:Female; D005283:Fentanyl / Q000008:administration & dosage* / Q000494:pharmacology; D006339:Heart Rate / Q000187:drug effects; D006439:Hemodynamics / Q000187:drug effects; D006801:Humans; D006973:Hypertension / Q000517:prevention & control; D007442:Intubation, Intratracheal; D008297:Male; D008875:Middle Aged; D009204:Myocardial Revascularization; D011651:Pulmonary Artery / Q000502:physiology; D011669:Pulmonary Wedge Pressure / Q000187:drug effects; D013318:Stroke Volume / Q000187:drug effects; D013610:Tachycardia / Q000517:prevention & control; D016278:Ventricular Function, Right / Q000187:drug effects
chemical_list: D005283:Fentanyl; D005045:Etomidate