Pharmacological screening of few new 2-(substituted acetyl) amino-5-alkyl-1,3,4-oxadiazoles.
Nine new 2-(substituted acetyl) amino-5-alkyl-1,3,4-oxadiazoles were synthesised and confirmed on the basis of IR and nitrogen analysis. These were screened for spasmolytic, anti-inflammatory and their effects on blood pressure after determining ALD50. Compounds GK-4 i.e. 2-(diethylaminoacetyl)- amino-5-methyl-1,3,4-oxadiazole and GK-8 i.e. 2-(din-propylamino acetyl)-amino-5-ethyl-1,3,4-oxadiazole were found to be spasmolytic. Compound GK-6 i.e. 2-(diethylaminoacetyl)-amino-5-n-propyl-1,3,4-oxadiazole was found to be a potent hypotensive agent with the effect lasting for more than two hours.
Mishra
P
P
Department of Pharmaceutical Sciences, Dr. Harisingh Gour Vishwavidyalaya, Sagar.
Joshi
G K
GK
Shakya
A K
AK
Agrawal
R K
RK
Patnaik
G K
GK
D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology; D001794:Blood Pressure / Q000187:drug effects; D001831:Body Temperature / Q000187:drug effects; D002319:Cardiovascular System / Q000187:drug effects; D002415:Cats; D004353:Drug Evaluation, Preclinical; D005260:Female; D006168:Guinea Pigs; D066298:In Vitro Techniques; D007928:Lethal Dose 50; D008297:Male; D051379:Mice; D009126:Muscle Relaxation / Q000187:drug effects; D009130:Muscle, Smooth / Q000187:drug effects; D010069:Oxadiazoles / Q000138:chemical synthesis / Q000494:pharmacology* / Q000633:toxicity; D010276:Parasympatholytics / Q000494:pharmacology; D051381:Rats; D012007:Rectum / Q000187:drug effects; D013329:Structure-Activity Relationship
D000894:Anti-Inflammatory Agents, Non-Steroidal; D010069:Oxadiazoles; D010276:Parasympatholytics