Survey of the susceptibility patterns of Bacteroides fragilis group strains in France from 1977 to 1992.
Rates of antibiotic resistance within the Bacteroides fragilis group were monitored over a 15-year period in France by examining studies that employed the same methodology to test susceptibility of anaerobic bacteria. Chloramphenicol, metronidazole, beta-lactam/beta-lactamase inhibitor combinations and imipenem remained very active against Bacteroides fragilis. There was little or no change in rates of resistance to these antibiotics. Resistance to clindamycin increased from 1% in 1977 to a peak of 19% in 1987, and since then has remained at 8 to 12%. There was some evidence that resistance to most beta-lactam agents increased during the same period. These results emphasize the need for periodic surveys of resistance patterns of the Bacteroides fragilis group in each country.
Dubreuil
L
L
Faculté de Pharmacie, BP 83, Lille, France.
Breuil
J
J
Dublanchet
A
A
Sedallian
A
A
D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D001439:Bacteroides / Q000187:drug effects*; D001441:Bacteroides fragilis / Q000187:drug effects*; D002511:Cephalosporins / Q000494:pharmacology; D004352:Drug Resistance, Microbial; D005602:France; D008826:Microbial Sensitivity Tests; D010406:Penicillins / Q000494:pharmacology; D013997:Time Factors
D000900:Anti-Bacterial Agents; D002511:Cephalosporins; D010406:Penicillins