title: Thyrotropin-secreting pituitary microadenoma.
abstract: We present a 45-yr-old male with clinical signs and symptoms of mild hyperthyroidism, high serum levels of T3, T4, and FT4 as well as serum TSH concentration. The elevated alpha-subunit level and alpha-subunit/TSH molar ratio were also observed. These findings indicated the presence of hyperthyroidism due to inappropriate secretion of TSH, whose neoplastic origin was documented by nuclear magnetic resonance scan showing a 0. 6 cm pituitary adenoma. Selective pituitary adenomectomy was completely successful; alpha-subunit, TSH, T3, T 4, and FT4 normalized, and euthyroidism was restored. Light microscopic immunohistochemistry showed that the adenoma was composed of TSH-secreting cells.
authors.affiliation: Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea.
authors.forename: E J
authors.initials: EJ
authors.lastname: Lee
authors.forename: K R
authors.initials: KR
authors.lastname: Kim
authors.forename: K M
authors.initials: KM
authors.lastname: Lee
authors.forename: D H
authors.initials: DH
authors.lastname: Yoon
authors.forename: Y S
authors.initials: YS
authors.lastname: Kim
authors.forename: D I
authors.initials: DI
authors.lastname: Kim
authors.forename: W H
authors.initials: WH
authors.lastname: Jung
authors.forename: Y S
authors.initials: YS
authors.lastname: Chung
authors.forename: S K
authors.initials: SK
authors.lastname: Lim
authors.forename: H C
authors.initials: HC
authors.lastname: Lee
mesh_terms: D000236:Adenoma / Q000175:diagnosis / Q000378:metabolism* / Q000473:pathology; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D010911:Pituitary Neoplasms / Q000175:diagnosis / Q000378:metabolism* / Q000473:pathology; D013972:Thyrotropin / Q000378:metabolism*
chemical_list: D013972:Thyrotropin