[Esophageal tumor induction in monkeys].
The experiment used eight monkeys who had received such esophagotropic carcinogens as ethyl ester of N-nitrososarcosine and methyl-N-benzyl-N-nitrosamine. The animals were followed for 4 years. The former agent failed to induce cancer where as 3 monkeys who had received methyl-N-benzyl-N-nitrosamine in the total dose of 600, 625 and 720 mg developed esophageal tumors (papilloma-2 and squamous cell carcinoma-1) at days 527, 725 and 880 after the start of treatment. The biological and histological features of the tumors were close to those of their human counterparts.
Beniashvili
D Sh
DSh
Aleksandrov
V A
VA
Bardadze
K I
KI
Bespalov
V G
VG
Petrov
A S
AS
Sartaniia
M S
MS
D000818:Animals; D002273:Carcinogens; D002294:Carcinoma, Squamous Cell / Q000139:chemically induced* / Q000473:pathology; D004128:Dimethylnitrosamine / Q000031:analogs & derivatives; D004195:Disease Models, Animal; D004938:Esophageal Neoplasms / Q000139:chemically induced* / Q000473:pathology; D004945:Esophagoscopy; D004947:Esophagus / Q000473:pathology; D005260:Female; D008252:Macaca fascicularis; D008297:Male; D009602:Nitrosamines; D010212:Papilloma / Q000139:chemically induced* / Q000473:pathology; D013997:Time Factors
D002273:Carcinogens; D009602:Nitrosamines; C028099:N-nitrososarcosine ethyl ester; C014707:nitrosobenzylmethylamine; C013162:N-nitrososarcosine; D004128:Dimethylnitrosamine
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