title: Desmin and vimentin as markers of regeneration in muscle diseases.
abstract: Localization and distribution of desmin and vimentin have been studied in different neuromuscular disorders using monoclonal antibodies. We have demonstrated that vimentin, although virtually absent in normal human muscle fibers, is expressed in regenerating fibers in different neuromuscular disorders. Moreover, these fibers showed a strong positivity with desmin antibodies. In normal muscle fibers desmin is only localized at Z-line level. These results suggest that desmin and vimentin may be over-expressed during muscle regeneration processes, probably because of their importance in the structural organization of the sarcomere.
authors.affiliation: Istituto di Clinica Neurologica, Centro Dino Ferrari, Università degli Studi, Milano, Italy.
authors.forename: A
authors.initials: A
authors.lastname: Gallanti
authors.forename: A
authors.initials: A
authors.lastname: Prelle
authors.forename: M
authors.initials: M
authors.lastname: Moggio
authors.forename: P
authors.initials: P
authors.lastname: Ciscato
authors.forename: N
authors.initials: N
authors.lastname: Checcarelli
authors.forename: M
authors.initials: M
authors.lastname: Sciacco
authors.forename: A
authors.initials: A
authors.lastname: Comini
authors.forename: G
authors.initials: G
authors.lastname: Scarlato
mesh_terms: D000911:Antibodies, Monoclonal; D015415:Biomarkers; D003893:Desmin / Q000032:analysis*; D005455:Fluorescent Antibody Technique; D006801:Humans; D009135:Muscular Diseases / Q000378:metabolism* / Q000503:physiopathology; D012038:Regeneration / Q000502:physiology*; D014746:Vimentin / Q000032:analysis*
chemical_list: D000911:Antibodies, Monoclonal; D015415:Biomarkers; D003893:Desmin; D014746:Vimentin