Inhibitory effects of 2'-deoxy-5-styryluridine 5'-triphosphate analogs on retroviral reverse transcriptase and eukaryotic DNA polymerases.
Some sugar modified analogs of 2'-deoxy-E-5-styryluridine triphosphates were synthesized and examined for their inhibitory effects on eukaryotic DNA polymerases and HIV-1 reverse transcriptase. Among these compounds, 3'-azido-2',3'-dideoxy-E-5-styrylUTP (6) and 2',3'-dideoxy-E-5-styrylUTP (7) showed remarkable inhibitory effects on reverse transcriptase. The mode of action and the influence of the substituent at C-5 of 2',3'-dideoxyUTP analogs will be described.
Yamaguchi
T
T
Department of Biological Sciences, Nishi-Tokyo University, Yamanashi, Japan.
Izuta
S
S
Suzuki
M
M
Yoshida
S
S
Matsukage
A
A
Saneyoshi
M
M
D005057:Eukaryotic Cells / Q000201:enzymology; D054303:HIV Reverse Transcriptase; D019384:Nucleic Acid Synthesis Inhibitors; D018894:Reverse Transcriptase Inhibitors; D013343:Styrenes / Q000494:pharmacology*; D014544:Uridine Triphosphate / Q000031:analogs & derivatives* / Q000494:pharmacology
D019384:Nucleic Acid Synthesis Inhibitors; D018894:Reverse Transcriptase Inhibitors; D013343:Styrenes; D054303:HIV Reverse Transcriptase; D014544:Uridine Triphosphate