Immune reproductive failure: effect of nonspecific immunostimulation in mouse model.
There is much evidence that pregnancy loss may be immunologically mediated. Failure of the maternal immune system to actively support the pregnancy may be responsible for its demise. Potentiation of immune functions has been attempted in humans; however, the success of immunotherapy is still not clear. Thus immunotherapy experiments in mouse models are important. Nonspecific immuno-stimulation with complete Freund adjuvant (CFA) was shown in our laboratory to reverse the tendency to fetal loss in the CBA/J X DBA/2J mouse combination. CFA elevates the non-T lymphocyte population, decreases T-cell secreted lymphokines, and enhances macrophage-secreted monokines. However, a relationship between these changes and a beneficial effect of CFA on reproductive performance has to be proved. Information obtained from nonspecific immunopotentiation in the CBA/J-DBA/2J model may contribute the assessment of nonspecific immunotherapy in humans.
Strassburger
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Department of Embryology and Teratology, Sackler School of Medicine, Tel-Aviv University, Ramat-Aviv, Israel.
Carp
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Toder
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D000818:Animals; D003433:Crosses, Genetic; D004195:Disease Models, Animal; D005260:Female; D005327:Fetal Resorption / Q000209:etiology / Q000276:immunology* / Q000517:prevention & control; D005620:Freund's Adjuvant / Q000008:administration & dosage / Q000627:therapeutic use*; D007116:Immunization, Passive; D008222:Lymphokines / Q000032:analysis; D008297:Male; D051379:Mice; D008808:Mice, Inbred CBA / Q000276:immunology*; D008811:Mice, Inbred DBA / Q000276:immunology*; D015846:Monokines / Q000032:analysis; D011247:Pregnancy; D013601:T-Lymphocytes / Q000276:immunology; D013951:Thymus Hormones / Q000008:administration & dosage / Q000627:therapeutic use*; D014611:Vaccination / Q000009:adverse effects
D008222:Lymphokines; D015846:Monokines; D013951:Thymus Hormones; C014859:thymic humoral factor; D005620:Freund's Adjuvant