title: Low risk of viral infection after administration of vapor-heated factor VIII concentrate. International Investigator Group.
abstract: A multicenter prospective study was carried out to evaluate whether a vapor-heated factor VIII concentrate transmitted blood-borne viral infections over a surveillance period of 15 months. Thirty-five patients with hemophilia and von Willebrand disease who had never received any blood components were treated. Twenty-eight were analyzed and found not to have non-A, non-B hepatitis. Sera from 20 of these 28 patients were also tested for the antibody to the hepatitis C virus. None had sero-converted during the follow-up period. None of the patients analyzed developed markers of the hepatitis B virus (n = 17) or the human immunodeficiency virus (n = 31). This vapor-heated factor VIII concentrate carries a low risk of transmitting hepatitis and human immunodeficiency virus infection.
authors.affiliation: Centro Emofilia e Trombosi Angelo Bianchi Bonomi, Milan, Italy.
authors.forename: P M
authors.initials: PM
authors.lastname: Mannucci
authors.forename: K
authors.initials: K
authors.lastname: Schimpf
authors.forename: T
authors.initials: T
authors.lastname: Abe
authors.forename: L M
authors.initials: LM
authors.lastname: Aledort
authors.forename: K
authors.initials: K
authors.lastname: Anderle
authors.forename: D B
authors.initials: DB
authors.lastname: Brettler
authors.forename: M W
authors.initials: MW
authors.lastname: Hilgartner
authors.forename: P B
authors.initials: PB
authors.lastname: Kernoff
authors.forename: M
authors.initials: M
authors.lastname: Kunschak
authors.forename: C W
authors.initials: CW
authors.lastname: McMillan
mesh_terms: D001803:Blood Transfusion; D002648:Child; D003586:Cytomegalovirus Infections / Q000175:diagnosis / Q000209:etiology; D005169:Factor VIII / Q000627:therapeutic use*; D005500:Follow-Up Studies; D015658:HIV Infections / Q000175:diagnosis / Q000209:etiology; D006467:Hemophilia A / Q000628:therapy*; D006509:Hepatitis B / Q000175:diagnosis / Q000209:etiology; D006526:Hepatitis C / Q000175:diagnosis / Q000209:etiology; D006358:Hot Temperature; D006801:Humans; D011446:Prospective Studies; D014777:Virus Diseases / Q000175:diagnosis / Q000209:etiology / Q000517:prevention & control*; D014842:von Willebrand Diseases / Q000628:therapy*
chemical_list: D005169:Factor VIII