Two-dimensional electrophoretic protein patterns of reciprocal hybrids of the mouse strains DBA and C57BL.
Two-dimensional electrophoretic patterns of cytoplasmic liver proteins of the mouse were investigated in reciprocal hybrids of the two inbred mouse strains DBA and C57BL in order to establish whether strain-specific protein variants reveal a mode of inheritance compatible with the concept of genomic imprinting. Variants of this type were found to account for about 11% of approximately 200 variant protein spots scrutinized. Transmission of the maternal form of a variant protein was more frequent than transmission of the paternal form. Maternal/paternal transmission was observed only for proteins showing strain variations in their amount. The results are discussed in terms of the frequency of imprinted genes.
Vogel
T
T
Institut für Humangenetik, Freie Universität Berlin, FRG.
Klose
J
J
D000818:Animals; D003593:Cytoplasm / Q000737:chemistry; D015180:Electrophoresis, Gel, Two-Dimensional; D005260:Female; D005786:Gene Expression Regulation; D006824:Hybridization, Genetic / Q000235:genetics*; D008099:Liver / Q000737:chemistry*; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL / Q000235:genetics / Q000378:metabolism*; D008811:Mice, Inbred DBA / Q000235:genetics / Q000378:metabolism*; D011506:Proteins / Q000235:genetics* / Q000302:isolation & purification; D013045:Species Specificity
D011506:Proteins