4-(Aminomethyl)-1-aryl-2-pyrrolidinones, a new class of monoamine oxidase B inactivators.
Both 4-(aminomethyl)-1-phenyl-2-pyrrolidinone (4a) and 4-(aminomethyl)-1- (methoxyphenyl)-2-pyrrolidinone (4b) hydrochlorides were synthesized via a six-step sequence, which represents a general approach to 1,4-disubstituted 2-pyrrolidinones. Both of these compounds inactivated monoamine oxidase B and represent the first in a new class of monomamine oxidase inactivators.
Ding
C Z
CZ
Department of Chemistry, Northwestern University, Evanston, Illinois 60208-3113.
Silverman
R B
RB
D000818:Animals; D000840:Anisoles / Q000138:chemical synthesis / Q000494:pharmacology*; D002417:Cattle; D007700:Kinetics; D008099:Liver / Q000201:enzymology; D008995:Monoamine Oxidase / Q000378:metabolism*; D008996:Monoamine Oxidase Inhibitors / Q000138:chemical synthesis / Q000494:pharmacology*; D011760:Pyrrolidinones / Q000138:chemical synthesis / Q000494:pharmacology*
D000840:Anisoles; D008996:Monoamine Oxidase Inhibitors; D011760:Pyrrolidinones; C082707:4-aminomethyl-1-phenyl-2-pyrrolidinone; C082708:4-aminomethyl-1-(4-methoxyphenyl)-2-pyrrolidinone; D008995:Monoamine Oxidase