title: Early detection of heart transplant rejection using cardiac echography combined with the assay of glycosylated residues in plasma by proton NMR spectroscopy.
abstract: Early diagnosis of acute cardiac graft rejection by non-invasive methods is required for medical, organizational, psychological and economic reasons. We have monitored 18 heart recipients over a period of 2.5 years using endomyocardial biopsies (EMB), cardiac Doppler-echography (CDE) and proton NMR spectroscopy assay of plasma glycosylated residues. Diastolic parameters of CDE and assay of the glycosylated residues by NMR spectroscopy respectively detect 42 and 45% of the acute low grade (mild or moderate) histological rejections. The combination of the two methods allows the detection of 65% of rejections. The strategy combining plasma NMR spectroscopy and echography is pertinent to the non-invasive detection of acute cardiac rejections with low histological grade.
authors.affiliation: Centre de Résonance magnétique biologique et médicale, U.R.A.-C.N.R.S. n. 1186, Faculté de Médecine, Marseille.
authors.forename: J
authors.initials: J
authors.lastname: Vion-Dury
authors.forename: A
authors.initials: A
authors.lastname: Mouly-Bandini
authors.forename: P
authors.initials: P
authors.lastname: Viout
authors.forename: M
authors.initials: M
authors.lastname: Sciaky
authors.forename: S
authors.initials: S
authors.lastname: Confort-Gouny
authors.forename: J R
authors.initials: JR
authors.lastname: Montiès
authors.forename: P
authors.initials: P
authors.lastname: Cozzone
mesh_terms: D000328:Adult; D000368:Aged; D015150:Echocardiography, Doppler / Q000379:methods*; D005260:Female; D005500:Follow-Up Studies; D006031:Glycosylation; D006084:Graft Rejection / Q000097:blood / Q000000981:diagnostic imaging / Q000517:prevention & control*; D016027:Heart Transplantation; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D008875:Middle Aged; D012680:Sensitivity and Specificity