[The determination of myocardial necrosis in unstable angina by the immunoradiometric measurement of circulating myosin].
Ventricular myosin heavy chains serum levels are a new marker of myocardial necrosis. We have studied plasma levels of myosin in 30 patients with unstable angina, 30 patients with acute myocardial infarction and 25 healthy subjects. The myosin peak level was 317 +/- 101 microU/L in angina patients, 2510 +/- 433 microU/L in infarcted patients and 62.3 +/- 17 microU/L in the controls. In both groups, the increase in serum myosin was more marked in those with larger infarction and in those with more severe angina. These data suggest that the measurement of serum myosin can identify the presence of micronecrosis in patients with unstable angina, according to what has been found using other markers of myocellular necrosis.
Tosti-Guerra
C
C
Istituto di Clinica Medica II, Università degli Studi, Firenze.
Carloni
V
V
Morace
G
G
Vitolo
A
A
Morace
G
G
D000328:Adult; D000368:Aged; D000789:Angina, Unstable / Q000097:blood* / Q000473:pathology; D015415:Biomarkers / Q000097:blood; D006801:Humans; D015592:Immunoradiometric Assay; D008875:Middle Aged; D009203:Myocardial Infarction / Q000097:blood / Q000473:pathology; D009206:Myocardium / Q000473:pathology*; D009218:Myosins / Q000097:blood*; D009336:Necrosis
D015415:Biomarkers; D009218:Myosins
Individuazione della necrosi miocardica nell'angina instabile mediante dosaggio immunoradiometrico della miosina circolante.