title: [Chronic neutrophilic leukemia associated with myeloma. Simultaneous presentation].
abstract: A case of chronic neutrophilic leukaemia associated with multiple myeloma is reported. The patient had a 6 months history of bruising and weight loss, and showed mature neutrophilic leukocytosis, hepatosplenomegaly, high neutrophil alkaline phosphatase score, hyperuricaemia, neutrophils with pseudotoxic granulation and scarce Döhle bodies; moreover, a monoclonal IgG lambda was detected amounting 57.3 g/L. The bone marrow was grossly hypercellular with marked myeloid hyperplasia and aggregates of immature plasma cells. After treatment during 1 year with melphalan and prednisone she is well, although persisting with neutrophilic leukocytosis, slight splenomegaly, and the monoclonal IgG decreased to 25.8 g/L.
authors.affiliation: Servicio de Hematología y Hemoterapia, Hospital General de Huelva.
authors.forename: J C
authors.initials: JC
authors.lastname: Diéguez
authors.forename: A
authors.initials: A
authors.lastname: Fernández Jurado
authors.forename: A
authors.initials: A
authors.lastname: Amián
authors.forename: J N
authors.initials: JN
authors.lastname: Rodríguez
authors.forename: M L
authors.initials: ML
authors.lastname: Martino
authors.forename: M
authors.initials: M
authors.lastname: Cañavate
authors.forename: D
authors.initials: D
authors.lastname: Prados
mesh_terms: D001853:Bone Marrow / Q000473:pathology; D005260:Female; D006801:Humans; D015994:Incidence; D015467:Leukemia, Neutrophilic, Chronic / Q000150:complications* / Q000453:epidemiology / Q000235:genetics / Q000473:pathology; D008875:Middle Aged; D009101:Multiple Myeloma / Q000150:complications* / Q000235:genetics / Q000473:pathology; D010950:Plasma Cells / Q000473:pathology
vernacular_title: Leucemia neutrofílica crónica asociada a mieloma. Presentación simultánea.