The relative roles of C4A and C4B in prevention of immune precipitation, solubilisation and immune adherence.
C4A and C4B levels were measured in serum from 246 normal individuals. Complement-mediated solubilisation, assayed using alkaline phosphatase anti-alkaline phosphatase immune complexes (IC), correlated with both C4A and C4B levels. However, C4A and C4B levels showed no correlation with solubilisation of bovine serum albumin (BSA) ICs, or with the prevention of immune precipitation of BSA or alkaline phosphatase ICs, nor with immune adherence assayed using thyroglobulin and BSA ICs.
Holme
E R
ER
Department of Pathology, University of Glasgow, Western Infirmary, UK.
Veitch
J
J
Johnston
A
A
McKay
I C
IC
Whaley
K
K
D000936:Antigen-Antibody Complex / Q000276:immunology*; D003181:Complement C4 / Q000502:physiology; D015934:Complement C4a / Q000032:analysis / Q000276:immunology*; D015935:Complement C4b / Q000032:analysis / Q000276:immunology*; D004912:Erythrocytes / Q000378:metabolism; D006461:Hemolysis; D006801:Humans; D007104:Immune Adherence Reaction; D011233:Precipitin Tests; D011951:Receptors, Complement / Q000378:metabolism; D012709:Serum Albumin / Q000276:immunology*; D012995:Solubility
D000936:Antigen-Antibody Complex; D003181:Complement C4; D011951:Receptors, Complement; D012709:Serum Albumin; D015934:Complement C4a; D015935:Complement C4b