Interleukin-6 and granulocyte macrophage-CSF in the cerebrospinal fluid from HIV infected subjects with involvement of the central nervous system.
We detected the cytokines interleukin-6 (IL-6) and granulocyte macrophage-CSF (GM-CSF) by ELISA in the CSF and serum of 30 HIV-infected patients classified as AIDS dementia complex (ADC), and 20 subjects with other neurological diseases (OND). We have found a high incidence of detectable IL-6 and GM-CSF in the CSF of ADC patients compared with OND patients. No statistical differences were observed between both groups for serum IL-6 and GM-CSF levels. These results suggest an intrathecal synthesis of these cytokines and a possible involvement in the pathogenesis of ADC.
Perrella
O
O
D. Cotugno Hospital for Infectious Diseases, Naples.
Guerriero
M
M
Izzo
E
E
Soscia
M
M
Carrieri
P B
PB
D015526:AIDS Dementia Complex / Q000097:blood / Q000134:cerebrospinal fluid*; D000328:Adult; D002493:Central Nervous System Diseases / Q000097:blood / Q000134:cerebrospinal fluid; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D016178:Granulocyte-Macrophage Colony-Stimulating Factor / Q000097:blood / Q000134:cerebrospinal fluid*; D006801:Humans; D015850:Interleukin-6 / Q000097:blood / Q000134:cerebrospinal fluid*; D008297:Male
D015850:Interleukin-6; D016178:Granulocyte-Macrophage Colony-Stimulating Factor