[Effect of peptide immunomodulators on microlymphodynamics].
Study of changes of some microlymphocirculatory parameters on the mesentery of anesthesized female albino rats in application of immunomodulators in 3-4 concentrations showed the following. Lympholin and gordox caused no changes of the studied parameters (tonic activity, rate and amplitude of rhythmic phase activity, rate of lymph flow). With gradual increase of concentration, Tactivin caused a greater constriction of the lymph vessels with a reduction of the amplitude of contractions. The changes of the rate of contractions was dose-dependent with increase of the concentration the proportion of vessels with a diminished rate increased. Myelopid increased the rate of contractions with some increase in the rate of lymph flow. Dose-dependence was not found. Leukopeptide caused narrowing of the vessels with a dose-dependent increase of the lymph flow rate. Lienin only reduced the rate of the lymph flow.
Sakharchuk
T A
TA
Levin
Iu M
IuM
Lebedeva
L P
LP
Kulinskaia
E V
EV
D000276:Adjuvants, Immunologic / Q000494:pharmacology*; D000818:Animals; D005260:Female; D008208:Lymphatic System / Q000276:immunology*; D008297:Male; D010455:Peptides / Q000494:pharmacology*; D051381:Rats
D000276:Adjuvants, Immunologic; D010455:Peptides
Vliianie immunomoduliatorov peptidnoĭ prirody na mikrolimfodinamiku.