[The practical use of the determination of relative 32P accumulation in the tumor in breast cancer].
The level of relative accumulation of a 32P radionuclide was measured in 180 tumor samples obtained from 148 patients with stage I--IV breast cancer. Mean initial relative accumulation level (IRAL) was 1477 +/- 174% whereas that following effective conservative treatment (posttreatment) (PRAL)--486 +/- 81% (P < 0.01). The prognostic value of IRAL was established: in a group of stage III breast cancer, those with a high IRAL survived 2 years with no evidence of disease in 55.1 +/- 12.1% whereas those with a low IRAL--in 94.1 +/- 5.7% (P < 0.02). In patients undergoing conservative treatment, low PRAL proved predictive of complete response while high PRAL--of tumor progression. In patients with stage III breast cancer who had responded to preoperative treatment and had had a low PRAL, two-year locoregional recurrence rate was only 13% as compared to 68% in a similar group of patients with high PRAL (P < 0.02).
Portnoĭ
S M
SM
Gabuniia
R I
RI
Godin
V P
VP
Letiagin
V P
VP
D001943:Breast Neoplasms / Q000000981:diagnostic imaging* / Q000378:metabolism / Q000401:mortality / Q000473:pathology / Q000628:therapy; D003131:Combined Modality Therapy; D005260:Female; D006801:Humans; D009364:Neoplasm Recurrence, Local / Q000453:epidemiology; D009367:Neoplasm Staging; D010761:Phosphorus Radioisotopes / Q000493:pharmacokinetics; D011300:Preoperative Care; D011379:Prognosis; D011877:Radionuclide Imaging
D010761:Phosphorus Radioisotopes
Prakticheskoe ispol'zovanie opredeleniia otnositel'nogo nakopleniia 32P v opukholi pri rake molochnoĭ zhelezy.