[An analysis of the intracellular distribution of glucocorticoid hormones by using a mathematical model].
A mathematic model depicting the interaction of glucocorticoids with the target cell is proposed. Specific features of cortisol and dexamethasone distributions in thymocytes in a wide range of hormonal concentrations have been analyzed. It has been established that specific action of glucocorticoids is dependent on the binding affinity and the number of the binding sites of hormones in the topographically different cell receptor systems (intracellular and membrane glucocorticoid receptors).
Dukhanin
A S
AS
Zaretskiĭ
D V
DV
Garin
V R
VR
D000818:Animals; D002462:Cell Membrane / Q000378:metabolism; D003600:Cytosol / Q000378:metabolism; D003907:Dexamethasone / Q000493:pharmacokinetics; D004305:Dose-Response Relationship, Drug; D005938:Glucocorticoids / Q000493:pharmacokinetics*; D006854:Hydrocortisone / Q000493:pharmacokinetics; D008297:Male; D008433:Mathematics; D008954:Models, Biological; D051381:Rats; D011965:Receptors, Glucocorticoid / Q000378:metabolism; D013950:Thymus Gland / Q000166:cytology / Q000378:metabolism*; D014316:Tritium
D005938:Glucocorticoids; D011965:Receptors, Glucocorticoid; D014316:Tritium; D003907:Dexamethasone; D006854:Hydrocortisone
Analiz vnutrikletochnogo raspredeleniia gliukokortikoidnykh gormonov s primeneniem matematicheskoĭ modeli.