Isolated severe thrombocytopenia and bleeding caused by piperacillin.
Bleeding and severe thrombocytopenia developed in a 71-year-old man who had been receiving piperacillin 5 g intravenously every 8 h for 9 days for the treatment of Pseudomonas aeruginosa septicemia. After piperacillin was discontinued, the platelet counts became normal. Rechallenge was made with 2 g of piperacillin intravenously resulting in thrombocytopenia within 6 h of piperacillin administration. The platelet count normalized after 3 days when no further piperacillin was given.
Olivera
E
E
Department of Internal Medicine, St. Elizabeth Hospital Medical Center, Youngstown, Ohio 44501-1790.
Lakhani
P
P
Watanakunakorn
C
C
D000368:Aged; D005884:Gingival Hemorrhage / Q000139:chemically induced*; D006801:Humans; D007275:Injections, Intravenous; D008297:Male; D008551:Melena / Q000139:chemically induced*; D010878:Piperacillin / Q000008:administration & dosage / Q000009:adverse effects*; D013921:Thrombocytopenia / Q000139:chemically induced*
D010878:Piperacillin