title: Rifamycins as inhibitors of retroviral reverse transcriptase from M-MuLV, RAV-2, and HIV-1.
abstract: 29 Rifamycins were tested for inhibition of Reverse Transcriptase (RT) as potential anti HIV drugs. Two purified commercial enzymes from M-MuLV and RAV-2 were used. Anti-RT activity was also measured on a crude lysate of HIV-1. The results show that some derivatives have interesting levels of activity on isolated M-MuLV and RAV-2 RTs, while they are less active on the RT in the crude HIV-1 lysate. The active derivatives include oximes and hydrazones, alkylaminoderivatives, open ansa-chain derivatives and derivatives carrying a modified nucleoside.
authors.affiliation: Istituto di Strutturistica Chimica, G. Giacomello, CNR C.P. 10 00016, Roma, Italy.
authors.forename: C
authors.initials: C
authors.lastname: Bartolucci
authors.forename: L
authors.initials: L
authors.lastname: Cellai
authors.forename: P
authors.initials: P
authors.lastname: Di Filippo
authors.forename: A
authors.initials: A
authors.lastname: Segre
authors.forename: M
authors.initials: M
authors.lastname: Brufani
authors.forename: L
authors.initials: L
authors.lastname: Filocamo
authors.forename: A D
authors.initials: AD
authors.lastname: Bianco
authors.forename: M
authors.initials: M
authors.lastname: Guiso
authors.forename: V
authors.initials: V
authors.lastname: Brizzi
authors.forename: A
authors.initials: A
authors.lastname: Benedetto
mesh_terms: D054303:HIV Reverse Transcriptase; D015497:HIV-1 / Q000201:enzymology; D009052:Leukemia Virus, Murine / Q000201:enzymology; D008970:Molecular Weight; D012190:Retroviridae / Q000201:enzymology*; D018894:Reverse Transcriptase Inhibitors; D012294:Rifamycins / Q000138:chemical synthesis / Q000494:pharmacology*
chemical_list: D018894:Reverse Transcriptase Inhibitors; D012294:Rifamycins; D054303:HIV Reverse Transcriptase