title: MHC class II determinants on peripheral blood monocytes from newly diagnosed IDDM patients.
abstract: The expression of MHC class II determinants (HLA-DR, HLA-DP and Ia7) on peripheral blood monocytes (OKM1+ cells) was studied in 20 children with newly diagnosed IDDM. Monocytes of 10 children with IDDM and familial predisposition showed a statistically significant increase of HLA-DR expression when compared to control group (10 healthy children). There were no significant differences concerning Ia7 expression. HLA-DP expression was similar in all studied groups.
authors.affiliation: Department of Clinical Immunology, Polish-American Childrens Hospital, Karków.
authors.forename: A
authors.initials: A
authors.lastname: Pituch-Noworolska
authors.forename: H
authors.initials: H
authors.lastname: Dziatkowiak
authors.forename: M
authors.initials: M
authors.lastname: Zembala
mesh_terms: D000293:Adolescent; D001323:Autoantibodies / Q000032:analysis; D001327:Autoimmune Diseases / Q000276:immunology*; D002648:Child; D003922:Diabetes Mellitus, Type 1 / Q000276:immunology*; D000939:Epitopes / Q000276:immunology; D006681:HLA-D Antigens / Q000032:analysis*; D006801:Humans; D007515:Islets of Langerhans / Q000276:immunology; D009000:Monocytes / Q000276:immunology*
chemical_list: D001323:Autoantibodies; D000939:Epitopes; D006681:HLA-D Antigens