title: Disseminated intravascular coagulation in lupus erythematosus with acute liver damage.
abstract: A case of disseminated intravascular coagulation (DIC) in a patient with systemic lupus erythematosus (SLE) with acute liver dysfunction is described. A 37-year-old man with SLE developed acute DIC and marked liver damage after fracture of the right clavicle and pharyngitis. Treatment with high-dose steroids, heparin, antithrombin III, gabexate mesilate, and antibiotics resulted in prompt improvement. The recovery of an SLE patient after acute DIC and marked liver damage is considered very rare. We report here such a case and discuss the previous reports.
authors.affiliation: Department of Internal Medicine, Saga Medical School, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Shimamoto
authors.forename: M
authors.initials: M
authors.lastname: Sano
authors.forename: S
authors.initials: S
authors.lastname: Kaneda
authors.forename: S
authors.initials: S
authors.lastname: Tsunada
authors.forename: K
authors.initials: K
authors.lastname: Yamamoto
authors.forename: M
authors.initials: M
authors.lastname: Yamaguchi
mesh_terms: D000328:Adult; D000990:Antithrombin III / Q000008:administration & dosage; D004211:Disseminated Intravascular Coagulation / Q000150:complications* / Q000188:drug therapy; D004359:Drug Therapy, Combination; D016670:Gabexate / Q000008:administration & dosage; D006493:Heparin / Q000008:administration & dosage; D006801:Humans; D017114:Liver Failure, Acute / Q000150:complications* / Q000188:drug therapy; D008180:Lupus Erythematosus, Systemic / Q000150:complications* / Q000188:drug therapy; D008297:Male; D008775:Methylprednisolone / Q000008:administration & dosage
chemical_list: D016670:Gabexate; D000990:Antithrombin III; D006493:Heparin; D008775:Methylprednisolone