[Clonal proliferation of less mature granulocytic precursors (CFU-dG) under the influence of neoplastic B lymphocytes in low grade non-hodgkin's lymphomas].
The effect of peripheral blood lymphoma B cells from low grade malignancy non-Hodgkin's lymphoma patients (Kiel classification: lymphocytic, centrocytic, centroblastic-centrocytic lymphomas) on clonal growth of normal marrow granulocytic precursors (CFU-dG) was studied. Using in vivo diffusion chamber culture method it was shown that all the tested lymphoma cells enhanced the CFU-dG growth by releasing humoral factor(s). The effect of stimulation was cell-concentration and cell-source dependent. The colony stimulating activity produced by centrocytic lymphoma cells had higher potency than that released by centroblastic-centrocytic lymphoma cells, whereas lymphocytic lymphoma cells showed the lowest ability to generate the CFU-dG growth-promoting activity (p < 0.01). It was shown that the CFU-dG growth enhancing effect was independent of marrow-derived macrophages and T lymphocytes (p > 0.05). Normal peripheral blood B lymphocytes used as a control did not show any substantial effect on the granulocytic precursors proliferation.
Kozłowska-Skrzypczak
M
M
Kliniki Hematologii Instytutu Chorób Wewnetrznych A.M., Poznaniu.
Hansz
J
J
D001402:B-Lymphocytes / Q000276:immunology*; D002455:Cell Division; D002999:Clone Cells; D006801:Humans; D008228:Lymphoma, Non-Hodgkin / Q000276:immunology*; D013234:Stem Cells / Q000166:cytology*
Proliferacja klonalna mniej dojrzałych prekursorów układu granulocytarnego (k.u.-dG) pod wpływem nowotworowych limfocytów B chłoniaków nie-ziarniczych o niskim stopniu złośliwości.