[An immunohistochemical study of Langerhan's cells (LC), T-cells and the HLA antigen in human cornea].
The distribution of Langerhan's cells (LC), T-cell subsets, and HLA system in 12 normal and 7 morbid corneas, including 4 of suppurative corneal ulcer and 3 of uveogenic endophthalmitis, were investigated with monoclonal antibodies. The results revealed that a small amount of LC and T-cell subsets were present in the limbal region of normal corneas, while large numbers of LC and OKT4+ were observed in the corneas of suppurative ulcer. HLA-ABC antigens were expressed on the epithelial cells and keratocytes of the normal corneas, while the HLA-DR antigens were expressed on the surface of LC at the limbus.
Li
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Q
Department of Ophthalmology, Union Hospital, Tongji Medical University, Wuhan.
He
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YL
D000293:Adolescent; D000328:Adult; D000368:Aged; D003315:Cornea / Q000276:immunology*; D003320:Corneal Ulcer / Q000276:immunology; D009877:Endophthalmitis / Q000276:immunology; D005260:Female; D006680:HLA Antigens / Q000032:analysis*; D006684:HLA-DR Antigens / Q000032:analysis; D006801:Humans; D007150:Immunohistochemistry; D007801:Langerhans Cells / Q000276:immunology*; D008297:Male; D008875:Middle Aged; D016176:T-Lymphocyte Subsets / Q000276:immunology*; D006377:T-Lymphocytes, Helper-Inducer / Q000276:immunology
D006680:HLA Antigens; D006684:HLA-DR Antigens