[The abnormal cytokeratin expression in HBV-caused hepatitis, early-cirrhotic and cirrhotic livers, its mechanism and significance].
An ABC immunohistochemical study of the expression of cytokeratin (CK19 and CK18) was carried out in 315 cases of HBV-caused hepatitis, early-cirrhotic and cirrhotic livers. It was shown that hepatocytes in 73% of chronic active hepatitis (CAH) (80/110) and 81% of early-cirrhotic and cirrhotic livers (117/144) expressed CK19 (the abnormal CK expression), which could be of help in differentiating CAH from chronic persistent hepatitis, subtype CAH (mild, moderate to severe type) and in determining the activity of early-cirrhotic and cirrhotic livers. The abnormal CK expression was shown to be closely related to the activity of liver disorders. The CK19 expression in hepatocytes had the closest relations with the piece-meal necrosis of hepatocytes, isolation of hepatocytes into groups by connective tissue, and fibrosis. It is suggested that CK19 expression may be one of the local reactions to the piece-meal necrosis of hepatocytes.
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Department of Pathology, Tangdu Hospital, Fourth Military Medical University, Xi'an.
D002908:Chronic Disease; D006509:Hepatitis B / Q000378:metabolism*; D006521:Hepatitis, Chronic / Q000378:metabolism; D006801:Humans; D007150:Immunohistochemistry; D007633:Keratins / Q000032:analysis*; D008099:Liver / Q000473:pathology; D008103:Liver Cirrhosis / Q000378:metabolism*
D007633:Keratins