Blood-brain barrier transfer of L-Trp and alpha-MTrp in Li-treated rats.
Blood-brain barrier (BBB) transport for L-Trp and alpha-methyl-L-tryptophan was evaluated in Li-treated rats. Five different brain areas as well as left to right differences were examined. No left to right difference in the PS product was observed. Lithium treatment had a significant effect on the plasma concentration of Val, Leu and Ile but no effect on plasma total or free Trp. The ratio of plasma Trp to the sum of Leu, Val, Ile, Phe, Met and Tyr is increased in the Li-treated rats but not significantly. However, the ratio of Trp/(Val+Leu+Ile) is significantly increased in the Li-treated rats. The Km apparent (Kmapp) for the BBB Trp transport is significantly decreased (affinity of the carrier for Trp is increased) in the Li-treated rats. A decrease in the Kmapp is one of the possible factors responsible for an increase in the brain Trp concentration and subsequent increase in the brain serotonin synthesis in Li-treated rats.
Takada
A
A
Department of Neurology and Neurosurgery, McGill University, Canada.
Grdisa
M
M
Diksic
M
M
D000818:Animals; D001812:Blood-Brain Barrier; D001921:Brain / Q000187:drug effects / Q000378:metabolism; D002560:Cerebrovascular Circulation; D007532:Isoleucine / Q000097:blood; D007930:Leucine / Q000097:blood; D008094:Lithium / Q000494:pharmacology*; D051381:Rats; D014364:Tryptophan / Q000031:analogs & derivatives* / Q000097:blood / Q000378:metabolism*; D014633:Valine / Q000097:blood
D007532:Isoleucine; C020774:alpha-methyltryptophan; D014364:Tryptophan; D008094:Lithium; D007930:Leucine; D014633:Valine