Changes in the level of biogenic amines in experimentally infected and DEC treated proxy host mice.
The levels of biogenic amines, viz., epinephrine, histamine and dopamine were significantly altered in the blood and brain of the proxy host mice which were infected with the mf of Setaria digitata, a filarial parasite. When DEC, the drug of choice was administered to the infected mice, serotonine level was enhanced while the histamine level was decreased. The results were similar in normal mice which were given DEC.
Vijayanathan
L
L
Dept. of Biochemistry, University of Kerala, Karlyavattom, Thirivananthapuram, India.
Raj
R K
RK
D000818:Animals; D001923:Brain Chemistry; D004049:Diethylcarbamazine / Q000494:pharmacology*; D004298:Dopamine / Q000032:analysis* / Q000097:blood; D004837:Epinephrine / Q000032:analysis* / Q000097:blood; D005260:Female; D006632:Histamine / Q000032:analysis* / Q000097:blood; D051379:Mice; D012719:Setariasis / Q000188:drug therapy / Q000378:metabolism*
D006632:Histamine; D004049:Diethylcarbamazine; D004298:Dopamine; D004837:Epinephrine