[Changes in the level of DNA synthesis in a culture of Ehrlich ascites tumor cells under the action of different concentrations of a chalone-containing preparation].
The study was made of the effect of various concentrations of chalone-containing preparation from ascitic Ehrlich tumor on DNA synthesis in the tumor. The preparation was shown to suppress DNA synthesis in dose-dependent manner. The dose dependence was characterized by the effect of saturation which is likely to reflect binding of chalone molecules with specific cell receptors.
Gembitskiĭ
D S
DS
Antokhin
A I
AI
Romanov
Iu A
IuA
Popova
N Ia
NIa
D000818:Animals; D002286:Carcinoma, Ehrlich Tumor / Q000378:metabolism*; D004273:DNA, Neoplasm / Q000096:biosynthesis / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D006131:Growth Inhibitors / Q000494:pharmacology*; D008297:Male; D051379:Mice; D009368:Neoplasm Transplantation; D014407:Tumor Cells, Cultured / Q000187:drug effects / Q000378:metabolism
D004273:DNA, Neoplasm; D006131:Growth Inhibitors
Izmenenie urovnia sinteza DNK v kul'ture kletok astsitnoĭ opukholi Erlikha pod deĭstviem razlichnykh kontsentratsiĭ keĭlonsoderzhashchego preparata.