Influence of sodium valproate and carbamazepine on GSH levels in rat cerebral cortex.
The effects of sodium valproate (150 mg/kg) and carbamazepine (300 mg/kg), alone and in combination, on the content of glutathione (GSH) were investigated in the rat cerebral cortex. No modification was found either 4, 12 or 16 hours after treatment, suggesting that sodium valproate and carbamazepine do not affect the cortical GSH metabolism in rats.
Attaguile
G
G
Institute of Pharmacology, University of Catania, Italy.
Caruso
A
A
Cutuli
V M
VM
Di Giacomo
C
C
Russo
A
A
De Bernardis
E
E
Amico-Roxas
M
M
D000284:Administration, Oral; D000818:Animals; D002220:Carbamazepine / Q000494:pharmacology*; D002540:Cerebral Cortex / Q000187:drug effects* / Q000378:metabolism*; D004347:Drug Interactions; D005978:Glutathione / Q000378:metabolism*; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D014635:Valproic Acid / Q000494:pharmacology*
D002220:Carbamazepine; D014635:Valproic Acid; D005978:Glutathione