[Effect of ligustrazine controlled release capsule on pulmonary hemodynamic and right ventricular systolic time intervals in patients with cor pulmonale].
Before and after oral administration of Ligustrazine controlled release capsule, pulmonary hemodynamic and right ventricular systolic time intervals, arterial blood gas and TXA2/PGI2 were studied. It was shown that decreasing of pulmonary arterial pressure and pulmonary vessel resistance, and heart rate, increasing of cardiac output, right ventricular systolic time intervals and arterial blood gas improving after one course of treatment with Ligustrazine controlled release capsule. It suggested that vasodilation caused by Ligustrazine is probably related to its vasodilating pulmonary vessela and improving imbalance between TXA2/PGI2 in patients with Cor Pulmonale.
Peng
W
W
Department of Internal Medicine, Tongji Hospital, Tongji Medical University, Wuhan.
D000284:Administration, Oral; D000368:Aged; D000369:Aged, 80 and over; D003692:Delayed-Action Preparations; D005260:Female; D006439:Hemodynamics / Q000187:drug effects; D006801:Humans; D008297:Male; D008875:Middle Aged; D011652:Pulmonary Circulation / Q000187:drug effects*; D011660:Pulmonary Heart Disease / Q000188:drug therapy* / Q000503:physiopathology; D011719:Pyrazines / Q000008:administration & dosage* / Q000494:pharmacology; D013599:Systole / Q000187:drug effects; D014655:Vascular Resistance / Q000187:drug effects; D014665:Vasodilator Agents / Q000008:administration & dosage* / Q000494:pharmacology; D016278:Ventricular Function, Right / Q000187:drug effects*
D003692:Delayed-Action Preparations; D011719:Pyrazines; D014665:Vasodilator Agents; C017953:tetramethylpyrazine