[The hordox correction of excessive proteolytic activity and the sialic acid content of the blood under an emotional influence on rabbits].
The influence of the acute emotional stress on the activity of proteolysis and content of free sialic acids in the blood under usual conditions and after the preliminary introduction of gordox has been studied in the experiment on rabbits. It is established that the parallel rise of their levels under stress reflects degradation of glycoproteins and fragments containing sialic acids under the influence of the increased activity of proteinases. Gordox, together with the inhibition of excessive activation of proteolysis, prevents the rise of the level of sialic acids under the influence of the stress action. The conclusion is made that it is expedient to use inhibitors of proteolytic enzymes for prevention of cellular lesions in stress.
Tarasenko
L M
LM
Dev'iatkina
T O
TO
Hrebennikova
V P
VP
D000208:Acute Disease; D000818:Animals; D007611:Aprotinin; D004353:Drug Evaluation, Preclinical; D008297:Male; D010447:Peptide Hydrolases / Q000097:blood / Q000187:drug effects*; D011817:Rabbits; D012794:Sialic Acids / Q000097:blood*; D013315:Stress, Psychological / Q000097:blood / Q000188:drug therapy*; D014361:Trypsin Inhibitors / Q000627:therapeutic use*
D012794:Sialic Acids; D014361:Trypsin Inhibitors; C011475:gordox; D007611:Aprotinin; D010447:Peptide Hydrolases
Korektsiia hordoksom nadmirnoï aktyvnosti proteolizu ta vmistu sialovykh kyslot v krovi pid chas emotsiĭnoho vplyvu na kroliv.