title: Biocompatibility of synthetic oxygen carriers and fluorosurfactants.
abstract: A system for testing the biocompatibility of synthetic oxygen carriers is described including tests of hemolysis, complement activation and proliferation of cell lines or lymphocytes. Of 17 surfactants tested in this system, 6 were compatible in all tests while the other compounds showed individually differing patterns of incompatibility. We conclude that, in order to conduct a meaningful screening, a series of different assays has to be applied. Addition to our system of further assays covering cytokine induction and phagocytosis should be attempted.
authors.affiliation: DRK-Blutspendezentrale Ulm, BRD.
authors.forename: H
authors.initials: H
authors.lastname: Northoff
authors.forename: L
authors.initials: L
authors.lastname: Haidmann
authors.forename: P
authors.initials: P
authors.lastname: Reuter
authors.forename: J
authors.initials: J
authors.lastname: Mader
authors.forename: H
authors.initials: H
authors.lastname: Meinert
mesh_terms: D001672:Biocompatible Materials; D001802:Blood Substitutes; D005466:Fluorocarbons; D006461:Hemolysis / Q000276:immunology; D006801:Humans; D008213:Lymphocyte Activation / Q000276:immunology; D010100:Oxygen / Q000097:blood*; D013329:Structure-Activity Relationship
chemical_list: D001672:Biocompatible Materials; D001802:Blood Substitutes; D005466:Fluorocarbons; D010100:Oxygen