title: DNA cleaving modes in minor groove of DNA helix by esperamicin and calicheamicin antitumor antibiotics.
abstract: This study examines and compares DNA cleavage modes by several esperamicin derivatives and calicheamicin. We found that the deoxyfucose-anthranilate moiety is a key factor to determine their DNA cutting modes. Probably, the bulky moiety hinders the abstraction of hydrogen atom from deoxyribose by the C-1 carbon radical of phenylene diradical. On the basis of the experimental results, detailed DNA cleaving modes in DNA minor groove by esperamicin and calicheamicin have been discussed.
authors.affiliation: Institute for Chemical Research, Kyoto University, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Uesugi
authors.forename: Y
authors.initials: Y
authors.lastname: Sugiura
mesh_terms: D000617:Aminoglycosides; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D000903:Antibiotics, Antineoplastic / Q000494:pharmacology*; D004247:DNA / Q000737:chemistry / Q000187:drug effects*; D053281:Enediynes; D009690:Nucleic Acid Conformation; D010084:Oxidation-Reduction
chemical_list: D000617:Aminoglycosides; D000900:Anti-Bacterial Agents; D000903:Antibiotics, Antineoplastic; D053281:Enediynes; C055955:calicheamicin gamma(1)I; D004247:DNA; C047543:esperamicin A1