title: An outbreak of multidrug-resistant tuberculosis among hospitalized patients with the acquired immunodeficiency syndrome.
abstract: BACKGROUND
  Since 1990 several clusters of multidrug-resistant tuberculosis have been identified among hospitalized patients with the acquired immunodeficiency syndrome (AIDS). We investigated one such cluster in a voluntary hospital in New York.
  
  
  METHODS
  We compared exposures among 18 patients with AIDS in whom tuberculosis resistant to isoniazid and streptomycin was diagnosed from January 1989 through April 1990 (the case patients) with exposures among 30 control patients who had AIDS and tuberculosis susceptible to isoniazid, streptomycin, or both. We also compared exposures among the 14 case patients hospitalized during the six months before the diagnosis of tuberculosis (the exposure period) with those among 44 control patients with AIDS matched for duration of hospitalization. Mycobacterium tuberculosis isolates were typed with analysis of restriction-fragment-length polymorphism (RFLP).
  
  
  RESULTS
  Case patients with drug-resistant tuberculosis were significantly more likely than controls with drug-susceptible tuberculosis to have been hospitalized during their exposure periods (14 of 18 vs. 10 of 30) (odds ratio, 7.0; 95 percent confidence interval, 1.6 to 36; P = 0.006). Case patients hospitalized during their exposure periods were significantly more likely to have been hospitalized on the same ward as a patient with infectious drug-resistant tuberculosis than were either controls with drug-susceptible tuberculosis hospitalized during their exposure periods or controls matched for duration of hospitalization (13 of 14 vs. 2 of 10 and 23 of 44) (odds ratio, 52; 95 percent confidence interval, 3.1 to 2474; P less than 0.001; and odds ratio, infinity; 95 percent confidence interval, 2.4 to infinity; P = 0.005, respectively). Among those hospitalized on the same ward, the rooms of case patients were closer to that of the nearest patient with infectious tuberculosis than were the rooms of controls matched for duration of hospitalization. M. tuberculosis isolates from 15 of 16 case patients had identical patterns on RFLP analysis. Of 16 patients' rooms tested with air-flow studies, only 1 had the recommended negative-pressure ventilation.
  
  
  CONCLUSIONS
  Multidrug-resistant tuberculosis is readily transmitted among hospitalized patients with AIDS. Physicians must be alert to this danger and must enforce adherence to the measures recommended to prevent nosocomial transmission of tuberculosis.
authors.affiliation: Division of HIV/AIDS, Centers for Disease Control, Atlanta, GA 30333.
authors.forename: B R
authors.initials: BR
authors.lastname: Edlin
authors.forename: J I
authors.initials: JI
authors.lastname: Tokars
authors.forename: M H
authors.initials: MH
authors.lastname: Grieco
authors.forename: J T
authors.initials: JT
authors.lastname: Crawford
authors.forename: J
authors.initials: J
authors.lastname: Williams
authors.forename: E M
authors.initials: EM
authors.lastname: Sordillo
authors.forename: K R
authors.initials: KR
authors.lastname: Ong
authors.forename: J O
authors.initials: JO
authors.lastname: Kilburn
authors.forename: S W
authors.initials: SW
authors.lastname: Dooley
authors.forename: K G
authors.initials: KG
authors.lastname: Castro
mesh_terms: D000163:Acquired Immunodeficiency Syndrome / Q000150:complications*; D000328:Adult; D000392:Air Movements; D016022:Case-Control Studies; D016000:Cluster Analysis; D003428:Cross Infection / Q000453:epidemiology*; D004352:Drug Resistance, Microbial; D005260:Female; D006746:Hospital Bed Capacity, 500 and over; D006749:Hospital Design and Construction; D006788:Hospitals, Voluntary / Q000706:statistics & numerical data*; D006801:Humans; D007297:Inpatients; D007538:Isoniazid / Q000494:pharmacology; D007902:Length of Stay; D008297:Male; D009169:Mycobacterium tuberculosis / Q000187:drug effects / Q000302:isolation & purification; D009518:New York / Q000453:epidemiology; D013307:Streptomycin / Q000494:pharmacology; D014376:Tuberculosis / Q000453:epidemiology* / Q000635:transmission
chemical_list: D007538:Isoniazid; D013307:Streptomycin