[The nooglutil correction of functional disorders of the central nervous system caused by prenatal alcoholization in rats].
Administration of ethanol (5 g/kg/day, per os) to the pregnant rats evoked delayed impairments of the learning and memory in the offspring. Prenatal alcoholization of the animals attenuated the habituation of the exploration behavior in open field, impaired acquisition and retention of active avoidance in a shuttle box, increased slow activity of the EEG spectrum power, disturbed the function of the serotoninergic system in the brain cortex and of the dopaminergic system in the hippocamp. The new nootropic drug nooglutyl (N-5/hydroxynicotinoyl/-L-glutamic acid) administered in a dose of 25 mg/kg/day from the 8th to the 20th day of life prevented the above-mentioned delayed disturbances of higher integrative functions and biochemical processes in rat brain.
Trofimov
S S
SS
Ostrovskaia
R U
RU
Smol'nikova
N M
NM
Khromova
I V
IV
Krapivin
S V
SV
Krylova
A M
AM
Kovalev
G I
GI
Gaĭnetdinov
R R
RR
Liubimov
B I
BI
Voronina
T A
TA
D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects; D001921:Brain / Q000187:drug effects / Q000503:physiopathology; D001923:Brain Chemistry / Q000187:drug effects; D002493:Central Nervous System Diseases / Q000139:chemically induced / Q000188:drug therapy* / Q000503:physiopathology; D004353:Drug Evaluation, Preclinical; D000431:Ethanol / Q000633:toxicity*; D005260:Female; D005971:Glutamates / Q000494:pharmacology / Q000627:therapeutic use*; D006613:Higher Nervous Activity / Q000187:drug effects; D008297:Male; D009539:Nicotinic Acids / Q000494:pharmacology / Q000627:therapeutic use*; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects; D011619:Psychotropic Drugs / Q000494:pharmacology / Q000627:therapeutic use*; D051381:Rats
D005971:Glutamates; D009539:Nicotinic Acids; D011619:Psychotropic Drugs; C066295:nooglutil; D000431:Ethanol
Korrektsiia noogliutilom narusheniĭ funktsiĭ tsentral'noĭ nervnoĭ sistemy, vyzvannykh prenatal'noĭ alkogolizatsieĭ u krys.