[Masked Philadelphia chromosome: diagnostic implications in a case of chronic myeloid leukemia presenting in blast crisis].
We present a female patient with acute non-lymphoblastic leukemia (ANLL) and with haematologic features suggestive of its evolution from chronic myeloid leukaemia (CML), in which a bone marrow karyotype showing a "masked" Philadelphia (Ph) chromosome due to a variant translocation of complex type t(9;9;22)(q32;q34;q11) was found. We comment the peculiarities of this special Ph chromosome as well as the differential diagnostic problems between ANLL Ph(+) and CML with onset in blastic crisis.
Carrasco
J L
JL
Servicio de Citogenética, Facultad de Medicina, Universidad de la Laguna, Tenerife, Islas Canarias, España.
Hernández García
M T
MT
Otero
A
A
Vilar
M C
MC
Marsá
L
L
González Brito
G
G
García Miranda
J L
JL
Hernández Nieto
L
L
D000368:Aged; D001752:Blast Crisis / Q000175:diagnosis* / Q000473:pathology; D002892:Chromosomes, Human, Pair 22 / Q000648:ultrastructure; D002899:Chromosomes, Human, Pair 9 / Q000648:ultrastructure; D003937:Diagnosis, Differential; D005188:False Negative Reactions; D005260:Female; D015321:Gene Rearrangement; D006801:Humans; D007621:Karyotyping; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000175:diagnosis* / Q000473:pathology; D015470:Leukemia, Myeloid, Acute / Q000175:diagnosis*; D008957:Models, Genetic; D010677:Philadelphia Chromosome; D014178:Translocation, Genetic
Cromosoma Filadelfia enmascarado: implicaciones diagnósticas en un caso de leucemia mieloide crónica de presentación en crisis blástica.