Regulatory mechanisms in leukocyte adhesion: flexible receptors for sophisticated travelers.
Unstimulated leukocytes spend extended periods circulating in the blood, punctuated by migration through lymphoid areas and peripheral tissues. During transit, strong cell-cell interactions control immune surveillance and specialized effector functions. The structures and mechanisms that allow this flexible adhesion and migration behavior are the subject of this review.
Pardi
R
R
Laboratory of Immunology, Scientific Institute San Raffaele, Milan, Italy.
Inverardi
L
L
Bender
J R
JR
D000494:Allosteric Regulation; D000941:Antigens / Q000276:immunology; D002448:Cell Adhesion; D015815:Cell Adhesion Molecules / Q000145:classification / Q000502:physiology*; D002455:Cell Division; D002465:Cell Movement; D002634:Chemotaxis, Leukocyte; D007157:Immunologic Surveillance; D007962:Leukocytes / Q000166:cytology* / Q000276:immunology; D008954:Models, Biological; D011971:Receptors, Immunologic / Q000502:physiology; D015398:Signal Transduction
D000941:Antigens; D015815:Cell Adhesion Molecules; D011971:Receptors, Immunologic