[The effect of mexidol on the dynamics of the normalization of the neurochemical and behavioral parameters of rats after deprivation of the paradoxical sleep phase].
Using cytophotometric method it was shown that intraperitoneal injection of mexidol in the dose of 50 mg/kg resulted in a significant accumulation of proteins and RNA in cells of dorsal raphe nucleus (DRN) and locus coeruleus (LC) 6 hs following the injection. In rats deprived of paradoxical sleep for 24 hours, the effect of mexidol prevented the decrease in DRN proteins and RNA and even increased them, and prevented their decrease in LC. In the postdeprivation period, the beneficial effect of mexidol manifested itself in the acceleration of normalizing the levels of proteins and RNA in DRN and LC. The antistress effect of mexidol manifested itself also in the acceleration of normalizing the rat memory in the restoration period following the deprivation of paradoxical sleep. The normalization of metabolism and functional activity in serotonergic DRN is suggested to determine to a considerable extent the functional state of cerebral structures participating in the control of memory as well.
Taranova
N P
NP
Sokolova
N E
NE
Kudriavtseva
I N
IN
Voronina
T A
TA
Nerobkova
L N
LN
D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D001522:Behavior, Animal / Q000187:drug effects* / Q000502:physiology; D001923:Brain Chemistry / Q000187:drug effects / Q000502:physiology; D003592:Cytophotometry; D008125:Locus Coeruleus / Q000187:drug effects / Q000502:physiology; D008297:Male; D010847:Picolines / Q000494:pharmacology*; D011903:Raphe Nuclei / Q000187:drug effects / Q000502:physiology; D051381:Rats; D012892:Sleep Deprivation / Q000502:physiology; D012895:Sleep, REM / Q000187:drug effects* / Q000502:physiology; D013997:Time Factors
D000975:Antioxidants; D010847:Picolines; C070020:emoxypine succinate
Vliianie meksidola na dinamiku normalizatsii neĭrokhimicheskikh i povedencheskikh parametrov u krys posle lisheniia paradoksal'noĭ fazy sna.