Formation of benzo[a]pyrene-DNA adducts in blood monocytes from lung cancer patients with a familial history of lung cancer.
The in vitro formation of benzo[a]pyrene-DNA adducts was determined in peripheral blood monocytes of 22 lung cancer patients with at least one first-degree relative with lung cancer and compared to results obtained in 30 healthy controls. In patients, the mean (SEM) adduct formation was 2.8 (0.3) fmol/micrograms DNA as compared to 2.1 (0.1) fmol/micrograms in controls (p less than 0.05), and it was independent of age and smoking habits. These findings support the hypothesis that carcinogen-DNA adduct formation may be one factor of a constitutionally enhanced lung cancer risk.
Nowak
D
D
Krankenhaus Grosshansdorf, Zentrum für Pneumologie und Thoraxchirurgie.
Meyer
A
A
Schmidt-Preuss
U
U
Gatzemeier
U
U
Magnussen
H
H
Rüdiger
H W
HW
D000230:Adenocarcinoma / Q000097:blood* / Q000235:genetics; D000328:Adult; D000368:Aged; D001564:Benzo(a)pyrene / Q000378:metabolism*; D018288:Carcinoma, Small Cell / Q000097:blood* / Q000235:genetics; D002294:Carcinoma, Squamous Cell / Q000097:blood* / Q000235:genetics; D004247:DNA / Q000097:blood*; D018736:DNA Adducts; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000097:blood* / Q000235:genetics; D008297:Male; D008875:Middle Aged; D009000:Monocytes / Q000737:chemistry*
D018736:DNA Adducts; C056612:benzo(a)pyrene-DNA adduct; D001564:Benzo(a)pyrene; D004247:DNA