title: [HIV-1 infection in patients with hemophilia. The Argentinian experience from 1983 to 1990].
abstract: We present studies on the evolution of HIV-1 infection in 638 hemophilic patients receiving commercial antihemophilic concentrates (CAH) at the Institute of Hematological Research and the Argentine Foundation of Hemophilia between 1983 and 1990. Positive serology for HIV-1 was detected in 30% of the patients studied. Prevalence of HIV-1 infection was higher (about 70%) in the group with severe hemophilia requiring more CAH, but there were no differences between patients with hemophilia A or B. Sexual transmission was demonstrated in 8/64 women (13%) with stable sexual relationship with HIV-1 + hemophilic patients. Three of them became pregnant, and HIV-1 infection was demonstrated in two of the three children. In general, the clinical evolution, as well as the hematologic and immunologic parameters of infected patients were similar to those described for the hemophilic population in other occidental countries. Opportunistic infections were also those observed elsewhere (with predominance of P. carinii pneumonia and disseminated Candida infections). However, the presence of fatal chagasic encephalitis in two of the patients with AIDS is unusual. Thus, central nervous system localization of T. cruzi (which can be observed during the acute period of T. cruzi infection or in immunosuppressed patients), must be considered as a possible severe complication of HIV-1 disease in T. cruzi infected patients.
authors.affiliation: Instituto de Investigaciones Hematológicas, Academia Nacional de Medicina, Buenos Aires, Argentina.
authors.forename: R
authors.initials: R
authors.lastname: Pérez-Bianco
authors.forename: A
authors.initials: A
authors.lastname: Anselmo
authors.forename: A
authors.initials: A
authors.lastname: Soria
authors.forename: B
authors.initials: B
authors.lastname: Ruibal-Ares
authors.forename: M B
authors.initials: MB
authors.lastname: Bouzas
authors.forename: G
authors.initials: G
authors.lastname: Muchinik
authors.forename: M
authors.initials: M
authors.lastname: Aixalá
authors.forename: M M
authors.initials: MM
authors.lastname: de Bracco
authors.forename: M
authors.initials: M
authors.lastname: de Tezanos Pinto
mesh_terms: D017088:AIDS-Related Opportunistic Infections / Q000150:complications; D000163:Acquired Immunodeficiency Syndrome / Q000150:complications* / Q000453:epidemiology / Q000635:transmission; D001118:Argentina / Q000453:epidemiology; D014355:Chagas Disease / Q000150:complications; D004660:Encephalitis / Q000150:complications; D005260:Female; D006679:HIV Seropositivity / Q000175:diagnosis; D015528:HIV Seroprevalence; D006467:Hemophilia A / Q000150:complications*; D006505:Hepatitis / Q000150:complications; D006801:Humans; D008297:Male; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious
vernacular_title: Infección por HIV-1 en pacientes con hemofilia. La experiencia Argentina desde 1983 hasta 1990.