title: [The characteristics of eicosanoid synthesis in osteogenic sarcoma in children at puberty].
abstract: Levels of prostaglandin E (PGE), prostaglandin F2 alpha, prostacyclin A2, thromboxan B2 and leucotriene B4 assayed radioimmunologically were compared in 42 samples of osteogenic sarcoma and 22 samples of benign tumors and tumor-like lesions from children at the pubertal period. In osteogenic sarcoma samples, PGE and prostaglandin F2 alpha levels were higher than those of thromboxan B2, prostacyclin A2 and leucotriene B4. Osteogenic sarcoma revealed higher levels of the eicosanoids as compared to benign tumors and tumor-like lesions of the bone. An inverse correlation was established between PGE level and time of dissemination of osteogenic sarcoma. The role of eicosanoids in the pathogenesis of growth and dissemination of osteogenic sarcoma is discussed. The use of non-steroid anti-inflammatory drugs in complex treatment of osteogenic sarcoma of children at the pubertal period is suggested.
authors.forename: N E
authors.initials: NE
authors.lastname: Kushlinskiĭ
authors.forename: L S
authors.initials: LS
authors.lastname: Bassalyk
authors.forename: L T
authors.initials: LT
authors.lastname: Liakina
authors.forename: Iu N
authors.initials: IuN
authors.lastname: Solov'ev
authors.forename: Iu V
authors.initials: IuV
authors.lastname: Pashkov
authors.forename: A T
authors.initials: AT
authors.lastname: Amiraslanov
authors.forename: P A
authors.initials: PA
authors.lastname: Siniukov
authors.forename: L V
authors.initials: LV
authors.lastname: Valenteĭ
authors.forename: A N
authors.initials: AN
authors.lastname: Fedenko
authors.forename: V M
authors.initials: VM
authors.lastname: Abaev
mesh_terms: D000293:Adolescent; D001859:Bone Neoplasms / Q000737:chemistry / Q000378:metabolism* / Q000628:therapy; D002648:Child; D003131:Combined Modality Therapy; D015777:Eicosanoids / Q000032:analysis / Q000096:biosynthesis*; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000378:metabolism / Q000556:secondary; D008297:Male; D012516:Osteosarcoma / Q000737:chemistry / Q000378:metabolism* / Q000628:therapy; D011627:Puberty / Q000378:metabolism*; D011863:Radioimmunoassay; D013997:Time Factors
chemical_list: D015777:Eicosanoids
vernacular_title: Osobennosti sinteza éĭkozanoidov v osteogennoĭ sarkome deteĭ v pubertatnom periode.