[Nisoldipine in comparison with long-term nitrates].
Nisoldipine represents a new attractive second generation calcium channel blocker of the dihydropyridine-class for the treatment of all types of coronary artery disease. The effect on chronic ischemia is comparable to long-acting nitrates, side-effects have been rarely observed. The advantages will be the high vascular selectivity with only slight negative inotropic effect as well as a long-lasting positive influence on the myocardial metabolism. Up to now, no studies have been reported which compare nisoldipine and long-acting nitrates directly, but this calcium antagonist appears to influence duration and intensity of symptomatic and silent episodes of ischemia similar to the nitrates.
Eber
B
B
Medizinischen Universitätsklinik Graz.
Schumacher
M
M
Zweiker
R
R
Pokan
R
R
Klein
W
W
D000787:Angina Pectoris / Q000188:drug therapy; D000818:Animals; D003326:Coronary Circulation / Q000187:drug effects; D003327:Coronary Disease / Q000188:drug therapy*; D003329:Coronary Vasospasm / Q000188:drug therapy; D006801:Humans; D017202:Myocardial Ischemia / Q000188:drug therapy*; D015737:Nisoldipine / Q000627:therapeutic use*; D009566:Nitrates / Q000627:therapeutic use*
D009566:Nitrates; D015737:Nisoldipine
Nisoldipin im Vergleich zu Langzeitnitraten.