[Mutual influence of aminophyllin and cefotaxime in the treatment of pulmonary heart disease].
The serum Aminophyllin (TP) and Cefotaxime (CTX) concentration of the patients of pulmonary heart disease during alute attack were measured by HLPC at 2 h and 6 h after infusion. (1) TP and CTX alone were used (2) TP and CTX were used simultaneously. The result showed that the concentrations of TP were much higher, but CTX were much lower when use CTX and TP simultaneously, at 2 h and 6 h (P < 0.01, P < 0.05). The concentration of TP of pulmonary heart disease with heart failure was higher than without heart failure at 6 h when alone were used or simultaneous were used (P < 0.01), CTX wasn't correlated with heart failure. The concentrations of TP and CTX did not correlate with PaO2 and PaCO2. It showed that TP and CTX would not be used simultaneously.
Li
S Q
SQ
Medical University of Second Clinical College Department Medicine of China, Shenyang.
D000628:Aminophylline / Q000008:administration & dosage*; D002439:Cefotaxime / Q000008:administration & dosage*; D004344:Drug Incompatibility; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011660:Pulmonary Heart Disease / Q000188:drug therapy*
D000628:Aminophylline; D002439:Cefotaxime