title: Preterm infants with patent ductus arteriosus: treatment with an enteral preparation of indomethacin.
abstract: Forty-one preterm infants with a mean gestational age and birthweight of 29.7 weeks and 1322 g, respectively, were treated with an enteral preparation of indomethacin for the closure of haemodynamically significant patent ductus arteriosus. The indomethacin was prepared by diluting the content of the commercially available 25-mg indomethacin capsule with lactose by the method of trituration. The mixture was suspended in solution form just prior to administration to the infants. The ductus arteriosus was successfully closed in 29 infants, giving an overall success rate of 71%. The response to treatment was considered satisfactory, except for infants whose birthweights were less than 750 g. Only two infants (5%) developed major complications, both in the form of ileal perforation. As the outcome of treatment with this enteral preparation of indomethacin was comparable with that of the intravenous preparation reported in previous studies, it would be an acceptable alternative to the intravenous preparation in areas where the latter is not available or considered expensive.
authors.affiliation: Department of Paediatrics, Chinese University of Hong Kong, Prince of Wales Hospital, Shatin.
authors.forename: L Y
authors.initials: LY
authors.lastname: So
authors.forename: T F
authors.initials: TF
authors.lastname: Fok
authors.forename: R Y
authors.initials: RY
authors.lastname: Sung
authors.forename: J K
authors.initials: JK
authors.lastname: Ho
mesh_terms: D000284:Administration, Oral; D004374:Ductus Arteriosus, Patent / Q000188:drug therapy*; D004750:Enteral Nutrition; D006801:Humans; D007213:Indomethacin / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D007231:Infant, Newborn; D007235:Infant, Premature, Diseases / Q000188:drug therapy*; D012189:Retrospective Studies; D016896:Treatment Outcome
chemical_list: D007213:Indomethacin