title: [Effects of transdermal nicotine as an adjunct in smoking cessation therapy. A double-blind randomized study controlled with placebo].
abstract: To assess the smoking cessation efficacy of transdermal nicotine patches an adjunct to low-intervention therapy, we conducted a double-blind, placebo-controlled trial in 158 smokers. Participants were randomly assigned to one of the following three study regimens that required daily application of two 15-cm2 patches: 1) 24-hour nicotine delivery, 2) nicotine delivery during wakeful hours only, and 3) placebo. The impact of the three regimens on smoking cessation rates and tobacco withdrawal symptoms was examined. During the last 2 weeks of the trial, 39% of the 24-hour nicotine regimen delivery group, 35% of those on wakeful hour nicotine regimens, and 13.5% of the placebo treatment group achieved abstinence. Self-reported quit rates for the two nicotine patch-wearing regimens, as compared with that for the placebo group, continued to be significantly higher at 6 months. Moreover, compared with placebo, the transdermal nicotine patches significantly reduced tobacco withdrawal symptoms during the first few weeks of quitting. The differences in quit rates and tobacco withdrawal symptoms between the to active groups were not statistically significant. The patches were well tolerated both topically and systemically. We concluded that transdermal nicotine, when used as an adjunct to low-intervention therapy, significantly reduced tobacco withdrawal symptoms and enhanced smoking cessation rates.
authors.affiliation: University of Nebraska Medical Center, Omaha.
authors.forename: D M
authors.initials: DM
authors.lastname: Daughton
authors.forename: S A
authors.initials: SA
authors.lastname: Heatley
authors.forename: J J
authors.initials: JJ
authors.lastname: Prendergast
authors.forename: D
authors.initials: D
authors.lastname: Causey
authors.forename: M
authors.initials: M
authors.lastname: Knowles
authors.forename: C N
authors.initials: CN
authors.lastname: Rolf
authors.forename: R A
authors.initials: RA
authors.lastname: Cheney
authors.forename: K
authors.initials: K
authors.lastname: Hatlelid
authors.forename: A B
authors.initials: AB
authors.lastname: Thompson
authors.forename: F
authors.initials: F
authors.lastname: De Blasio
mesh_terms: D000279:Administration, Cutaneous; D000328:Adult; D003367:Cotinine / Q000032:analysis; D004311:Double-Blind Method; D006801:Humans; D008875:Middle Aged; D009538:Nicotine / Q000008:administration & dosage*; D012463:Saliva / Q000737:chemistry; D016540:Smoking Cessation / Q000379:methods* / Q000706:statistics & numerical data; D013375:Substance Withdrawal Syndrome
chemical_list: D009538:Nicotine; D003367:Cotinine
vernacular_title: Effetti del rilascio transdermico di nicotina come terapia di supporto per lo svezzamento dal fumo di sigaretta. Uno studio randomizzato in doppio cieco con controlli trattati con placebo.