[Effect of lipiodol-cisplatinum arterial infusion chemotherapy on cellular immunity].
A Lipiodol-cisplatinum suspension (LPD/CDDP) was applied by intrahepatic arterial infusion chemotherapy to treat 15 cases of inoperable hepatoma. Pre- and post-application changes in leucocytes, monocytes, platelets and lymphocytes in patients were examined. Natural killer activity was determined and analysis by two-color method was performed. After infusion chemotherapy, leucocytosis and monocytosis were quite conspicuous. NK activity was reduced after application of LPD/CDDP, but this effect may have been partly due to the influence of methylprednisolone. Cellular immunity was not influenced by LPD/CDDP infusion without low reduction of NK activity.
Ohsumi
M
M
Dept. of Surgery, Kusatsu Branch Hospital, Gunma University School of Medicine, Japan.
Koitabashi
H
H
Nagamachi
Y
Y
Iijima
T
T
D006528:Carcinoma, Hepatocellular / Q000188:drug therapy / Q000276:immunology*; D002945:Cisplatin / Q000008:administration & dosage*; D006499:Hepatic Artery; D006801:Humans; D007111:Immunity, Cellular; D007261:Infusions, Intra-Arterial; D007459:Iodized Oil / Q000008:administration & dosage*; D007694:Killer Cells, Natural / Q000276:immunology*; D008113:Liver Neoplasms / Q000188:drug therapy / Q000276:immunology*; D008775:Methylprednisolone / Q000008:administration & dosage; D008875:Middle Aged; D016176:T-Lymphocyte Subsets
D007459:Iodized Oil; D002945:Cisplatin; D008775:Methylprednisolone