Mobilized blood stem cells: immunophenotyping and functional characteristics.
High levels of peripheral blood stem cells (PBSC) can be collected from patients with hematopoietic malignancies or solid tumors after high-dose chemotherapy and/or growth factors. Rapid, complete, and durable hematopoietic reconstitution has been observed in patients who have been transplanted with PBSC after conditioning with supralethal myeloablative therapy. We will review the recent data concerning the immunophenotype and functional capacities of mobilized blood stem cells. PBSC seem to be comprised of a mixture of primitive and committed hematopoietic progenitors and are not that different from bone marrow-derived stem cells.
Rice
A
A
Bone Marrow Transplant Laboratory, URA CNRS 1456, University of Bordeaux II, France.
Reiffers
J
J
D002478:Cells, Cultured; D016179:Granulocyte Colony-Stimulating Factor / Q000627:therapeutic use; D006412:Hematopoietic Stem Cells / Q000187:drug effects / Q000276:immunology*; D006801:Humans; D016130:Immunophenotyping
D016179:Granulocyte Colony-Stimulating Factor