Clinical effect of a triclosan-containing dentifrice on plaque and gingivitis: a six-month study.
A total of 294 adult male and female subjects completed a 6-month, double-blind clinical trial designed to evaluate the effects of a dentifrice which contained 0.3% triclosan in conjunction with 2% of a methoxyethylene/maleic acid copolymer in a 0.243% sodium fluoride/silica base, relative to a control dentifrice, on supragingival plaque accumulation and gingivitis. Plaque and gingivitis were scored after 3 and 6-month use of the assigned dentifrice. At the end of the study, the triclosan group showed an average reduction, relative to the control group, of 12% in plaque accumulation and 20% in gingivitis. Both were statistically significant at p < or = 0.0001. The effect of the triclosan dentifrice was most pronounced on the more severe manifestations of plaque and gingivitis. The improvement in the gingival parameters at 6-months relative to the control dentifrice was statistically significant at p < or = 0.0001. It was concluded that the twice-daily use of the triclosan-containing dentifrice resulted in significant reduction in supragingival plaque formation and a significant improvement in gingival health without the presence of any extrinsic staining or objectionable taste.
Mankodi
S
S
Clinical Dental Research, Besselaar Clinical Research Unit, West Palm Beach, Florida.
Walker
C
C
Conforti
N
N
DeVizio
W
W
McCool
J J
JJ
Volpe
A R
AR
D000293:Adolescent; D000328:Adult; D000704:Analysis of Variance; D003773:Dental Plaque / Q000517:prevention & control*; D003774:Dental Plaque Index; D003802:Dentifrices / Q000627:therapeutic use*; D004311:Double-Blind Method; D005260:Female; D005891:Gingivitis / Q000188:drug therapy*; D006801:Humans; D008137:Longitudinal Studies; D008297:Male; D008298:Maleates / Q000627:therapeutic use*; D008875:Middle Aged; D010512:Periodontal Index; D011145:Polyvinyls / Q000627:therapeutic use*; D014260:Triclosan / Q000627:therapeutic use*
D003802:Dentifrices; D008298:Maleates; D011145:Polyvinyls; C058026:polyvinylmethoxyethylene-maleic anhydride copolymer; D014260:Triclosan