Plasmid copy number control: a case study of the quasi-steady-state assumption.
Perelson & Brendel (1989, J. molec. Biol. 208, 245-255) have proposed kinetic models for the control of plasmid copy number, based on experiments by J. Tomizawa and his associates. The quasi-steady-state assumptions (QSSA) made in the analysis of these models are justified in the present paper, thereby providing an example of how QSSA can provide a powerful and reliable tool in the analysis of biological kinetics.
Segel
L A
LA
Department of Applied Mathematics and Computer Science, Weizmann Institute, Rehovot, Israel.
Perelson
A S
AS
D008957:Models, Genetic; D010957:Plasmids / Q000235:genetics*