title: [Genetic principles of malignant transformation].
abstract: Genetic alterations such as translocations, deletions or point mutations often result in a loss of function. Such alterations may contribute to oncogenesis by interference with mechanisms restraining cellular growth. However, mutations of protooncogenes can also result in abnormal positive signals for cell proliferation. Some concepts resulting from genetic approaches to identify the genes that may be involved in the regulation of cell multiplications are discussed.
authors.affiliation: Institut für Medizinische Chemie und Biochemie, Universität Innsbruck.
authors.forename: K
authors.initials: K
authors.lastname: Maly
mesh_terms: D002455:Cell Division / Q000235:genetics*; D002471:Cell Transformation, Neoplastic / Q000235:genetics*; D002869:Chromosome Aberrations / Q000235:genetics*; D016147:Genes, Tumor Suppressor / Q000235:genetics; D006801:Humans; D009369:Neoplasms / Q000235:genetics; D009857:Oncogenes / Q000235:genetics*
vernacular_title: Genetische Grundlagen der malignen Transformation.