title: [Antimalarial effect of n-hentriacontanol isolated from Cuatresia sp (Solanaceae)].
abstract: The antimalarial activity of the fatty alcohol, n-hentriacontanol, isolated from the bolivian Solanaceae, Cuatresia sp, is investigated in vivo through a classical four-day suppressive test against Plasmodium berghei and P. vinckei in mice. This product markedly reduced the virulence of experimentally induced P. vinckei infection. n-Hentriacontanol belongs to a new class of antimalarial natural compounds to be exploited for therapeutic purposes.
authors.affiliation: IBBA-ORSTOM, La Paz, Bolivie.
authors.forename: E
authors.initials: E
authors.lastname: Deharo
authors.forename: M
authors.initials: M
authors.lastname: Sauvain
authors.forename: C
authors.initials: C
authors.lastname: Moretti
authors.forename: B
authors.initials: B
authors.lastname: Richard
authors.forename: E
authors.initials: E
authors.lastname: Ruiz
authors.forename: G
authors.initials: G
authors.lastname: Massiot
mesh_terms: D000818:Animals; D000962:Antimalarials / Q000627:therapeutic use; D001838:Bolivia; D008288:Malaria / Q000188:drug therapy*; D051379:Mice; D010946:Plants, Medicinal; D010961:Plasmodium / Q000187:drug effects; D010962:Plasmodium berghei / Q000187:drug effects
chemical_list: D000962:Antimalarials
vernacular_title: Activité antipaludique du n-hentriacontanol isolé de Cuatresia sp (Solanaceae).