title: Chemodectoma of the head and neck: results of treatment in 84 patients.
abstract: Eighty-four patients with chemodectoma of the head and neck presented to the Royal Marsden Hospital between 1949 and 1985. For tumors arising at the skull base (glomus jugulare and glomus tympanicum) 46 were treated with radiotherapy alone resulting in an actuarial local control rate of 73% at 25 years; 13 were treated with surgery plus radiotherapy with no recurrences during a median follow-up of 9 years; 4 had surgery alone but all recurred by 7 years. For tumors of the soft tissues of the neck (carotid body and glomus vagale) 13 were treated with surgery alone with an actuarial control rate of 54% at 15 years; 4 were treated with radiotherapy which resulted in local control at 1, 2, 8 and 11 years; and one patient who received both surgery and radiotherapy remained controlled at 1 year. Although comparison between radiotherapy and surgery in terms of tumor control is not simple, the case is argued for more frequent use of radiotherapy at all sites. This case is strengthened by minimal morbidity from radiotherapy in doses which appear effective: in the range of 45-50 Gy in 25 daily fractions over 5 weeks.
authors.affiliation: Head and Neck Unit, Royal Marsden Hospital, London, England.
authors.forename: S
authors.initials: S
authors.lastname: Powell
authors.forename: N
authors.initials: N
authors.lastname: Peters
authors.forename: C
authors.initials: C
authors.lastname: Harmer
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002345:Carotid Body Tumor / Q000453:epidemiology / Q000532:radiotherapy / Q000601:surgery; D003131:Combined Modality Therapy; D004739:England / Q000453:epidemiology; D005260:Female; D005925:Glomus Jugulare Tumor / Q000453:epidemiology / Q000532:radiotherapy / Q000601:surgery; D006258:Head and Neck Neoplasms / Q000453:epidemiology / Q000532:radiotherapy* / Q000601:surgery; D006801:Humans; D008297:Male; D008875:Middle Aged; D010236:Paraganglioma, Extra-Adrenal / Q000453:epidemiology / Q000532:radiotherapy* / Q000601:surgery; D012189:Retrospective Studies; D016896:Treatment Outcome