Mathematical model for agonist-induced oscillatory calcium waves in non-excitable mammalian cells.
Many non-excitable cells display cytosolic Ca2+ oscillations resulting from the periodic release of Ca2+ from intracellular stores. Recent observations in hepatocytes and some other cell types have shown that agonist-induced Ca2+ oscillations often display an intracellular spatial organization and do not occur synchronously within the cell. Ca2+ waves evoked by different agonists originate from the same subcellular locus and propagate through the cell with a constant rate of progress and amplitude. This indicates that Ca2+ waves are driven by a self-propagating mechanism and not by diffusion alone. We propose a simplified one-dimensional mathematical model to describe this phenomenon based on the mechanism of calcium-induced calcium release. The numerical solution of the system of two coupled non-linear partial differential equations reproduces many of the main features observed experimentally.
Kraus
M
M
AG Medizinische Physik und Elektronenmikroskopie, Albert-Ludwigs-Universität, Freiburg, FRG.
Wolf
B
B
D000818:Animals; D002118:Calcium / Q000378:metabolism*; D003198:Computer Simulation; D003600:Cytosol / Q000378:metabolism; D006801:Humans; D015544:Inositol 1,4,5-Trisphosphate / Q000378:metabolism; D008099:Liver / Q000378:metabolism; D008954:Models, Biological; D015398:Signal Transduction / Q000502:physiology
D015544:Inositol 1,4,5-Trisphosphate; D002118:Calcium