[Correlation of antianginal effect of corinfar and diastolic function in patients with ischemic heart disease].
The study was undertaken to examine 45 patients with coronary heart disease and 14 healthy subjects by using radionuclide ventriculography, apex- and echocardiographies, bicycle ergometry, transesophageal electrocardiostimulation before therapy and at the action peak of corinfar in a dose of 30 mg. It was shown that corinfar failed to affect the unaltered diastolic function of the left ventricle. The normalizing effect of corinfar on left ventricular stiffness was found to result in higher coronary reserve, significantly enhanced exercise tolerance and to be an important mechanism of antianginal effect of the drug. Impaired left ventricular stiffness may be an additional criterion for using corinfar in patients with coronary heart disease.
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Lomakovskiĭ
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AN
Stroganova
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D003971:Diastole; D006801:Humans; D008297:Male; D008875:Middle Aged; D017202:Myocardial Ischemia / Q000175:diagnosis / Q000188:drug therapy* / Q000503:physiopathology*; D009543:Nifedipine / Q000494:pharmacology* / Q000627:therapeutic use*; D016277:Ventricular Function, Left / Q000187:drug effects*
D009543:Nifedipine
Zavisimost antianginalńogo effecta corinfara ot sostoianiia diastolicheskoĭ funktsii serdtsa u bolńykh ishemicheskoĭ bolezníu serdtsa.