title: Relevance of plasma fibrinogen estimation in obstetric complications.
abstract: We present a study of fibrinogen levels in 133 patients who were prone to develop disseminated intravascular coagulation as a result of an underlying complication of pregnancy such as abruptio placentae, pregnancy-induced hypertension, missed abortion, septic abortion, intrauterine fetal death, vesicular mole and amniotic fluid embolism. A high incidence of hypofibrinogenemia was found in cases of abruptio placentae (43.9%) and pregnancy-induced hypertension (25%). Hypofibrinogenemia occurred in 10% cases of intrauterine fetal death within 4 weeks of fetal demise. The use of this simple investigation makes possible the diagnosis of hemostatic failure and also helps to guide replacement therapy during the fibrinopenic state. There were 4 maternal deaths and 12 perinatal losses in this study.
authors.affiliation: Dept of Gynaecology and Obstetrics, Seth GS Medical College, Parel, Bombay, Maharashtra.
authors.forename: H
authors.initials: H
authors.lastname: Parasnis
authors.forename: B
authors.initials: B
authors.lastname: Raje
authors.forename: I N
authors.initials: IN
authors.lastname: Hinduja
mesh_terms: D000037:Abruptio Placentae / Q000150:complications / Q000453:epidemiology; D004211:Disseminated Intravascular Coagulation / Q000097:blood* / Q000150:complications / Q000453:epidemiology; D005260:Female; D005313:Fetal Death / Q000453:epidemiology; D005340:Fibrinogen / Q000032:analysis*; D006801:Humans; D006973:Hypertension / Q000150:complications / Q000453:epidemiology; D015994:Incidence; D011247:Pregnancy; D011249:Pregnancy Complications, Cardiovascular / Q000453:epidemiology; D011250:Pregnancy Complications, Hematologic / Q000097:blood* / Q000453:epidemiology; D011256:Pregnancy Outcome; D011446:Prospective Studies; D012307:Risk Factors
chemical_list: D005340:Fibrinogen