[Experimental study on tea in inhibiting mutational specificity of 6 antineoplastic drugs].
According to the principles of SOS response, the authors tested the mutational specificity of tea and its inhibitory effects to the mutational specificity of 6 antineoplastic drugs by using the method of mutational and anti-mutational synchronous test. The results revealed that the tea had no mutational toxicity but anti-mutation effect. It also had the inhibitory effect on mutational toxicity of 6 antineoplastic drugs, including Mitomycin C, Bleomycin, Fluorouracil, Cisdiaminodichoroplatinum, Arabinosylcytosin and Mustargen. These results have provided referential basis for further study on anti-cancer effect and clinical use of tea.
Zhao
Z Z
ZZ
Hebei Cancer Institute, Shijiazhuang.
Huang
M T
MT
Li
Q
Q
D016587:Antimutagenic Agents / Q000494:pharmacology*; D000970:Antineoplastic Agents / Q000009:adverse effects*; D001761:Bleomycin / Q000009:adverse effects; D004926:Escherichia coli / Q000187:drug effects / Q000235:genetics; D005472:Fluorouracil / Q000009:adverse effects; D016685:Mitomycin / Q000009:adverse effects; D009154:Mutation / Q000187:drug effects; D010936:Plant Extracts / Q000494:pharmacology; D013014:SOS Response, Genetics / Q000187:drug effects*; D013662:Tea
D016587:Antimutagenic Agents; D000970:Antineoplastic Agents; D010936:Plant Extracts; D013662:Tea; D001761:Bleomycin; D016685:Mitomycin; D005472:Fluorouracil