[The effect of 6-methyluracil on oxidative reactions in model systems of varying degrees of complexity].
Effect of 6-methyluracyl (MU) on oxidative processes was studied on model systems of different degrees of complexity (methyloleate model, mitochondria isolated from rat liver, surviving slices of mammalian muscle tissues). On two former models it was shown that MU exerted antioxidant (AO) properties inferior to those of such antioxidants as ionol and K(+)-phenosan. The AO efficiency depended on the intensity of peroxide processes. The AO activity of MU was most fully realized on the model of isolated surviving slices of muscle tissue. The totality of data obtained suggests that participation of the substance in regulation of lipid peroxidation in the organism underlies its therapeutic activity in pathological states.
Shishkina
L N
LN
Taran
Iu P
IuP
Eliseeva
S V
SV
Bulgakov
V G
VG
D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D002084:Butylated Hydroxytoluene / Q000494:pharmacology; D066298:In Vitro Techniques; D015227:Lipid Peroxidation / Q000187:drug effects; D008930:Mitochondria, Liver / Q000187:drug effects / Q000378:metabolism; D009132:Muscles / Q000187:drug effects / Q000378:metabolism; D009829:Oleic Acids / Q000378:metabolism; D010084:Oxidation-Reduction / Q000187:drug effects; D010666:Phenylpropionates / Q000494:pharmacology; D011817:Rabbits; D051381:Rats; D013997:Time Factors; D014498:Uracil / Q000031:analogs & derivatives* / Q000494:pharmacology
D000975:Antioxidants; D009829:Oleic Acids; D010666:Phenylpropionates; D002084:Butylated Hydroxytoluene; C005576:methyl oleate; D014498:Uracil; C008378:6-methyluracil; C047854:fenozan
Vliianie 6-metiluratsila na okislitel'nye reaktsii v model'nykh sistemakh razlichnoĭ stepeni slozhnosti.