title: Alkaline phosphatase and phosphotyrosine phosphatase activities of cultured amniotic cells with trisomy 18.
abstract: In cultured amniotic cells from fetuses with Edward's syndrome (trisomy 18), the activities of two protein phosphatases, alkaline phosphatase and phosphotyrosine phosphatase, were measured. Comparison with normal fetal cells showed a different behavior for each enzyme. Alkaline phosphatase was significantly lowered while phosphotyrosine phosphatase remained at normal levels. The interest of these enzyme assays in the screening procedure of this severe chromosome defect is discussed.
authors.affiliation: Service Universitaire d'Hématologie (INSERM, CNRS), Faculté de Médecine de Toulouse Rangueil, France.
authors.forename: H
authors.initials: H
authors.lastname: Vergnes
authors.forename: J
authors.initials: J
authors.lastname: Grozdea
authors.forename: A
authors.initials: A
authors.lastname: Brisson-Lougarre
authors.forename: G
authors.initials: G
authors.lastname: Bourrouillou
authors.forename: P
authors.initials: P
authors.lastname: Colombies
mesh_terms: D000469:Alkaline Phosphatase / Q000032:analysis / Q000378:metabolism*; D000649:Amniocentesis; D000653:Amniotic Fluid / Q000166:cytology* / Q000201:enzymology; D002887:Chromosomes, Human, Pair 18; D005260:Female; D006801:Humans; D011247:Pregnancy; D011262:Pregnancy Trimester, Second; D017027:Protein Tyrosine Phosphatases / Q000032:analysis / Q000378:metabolism*; D012016:Reference Values; D014314:Trisomy
chemical_list: D000469:Alkaline Phosphatase; D017027:Protein Tyrosine Phosphatases