title: Lack of modulation effects of praziquantel on DMN-induced lesion development in the Syrian hamster liver.
abstract: The effects of repeated praziquantel administration subsequent to dimethylnitrosamine (DMN) treatment of Syrian hamsters were investigated. The antihelminthic drug was given (200 mg/kg body wt. as a suspension in corn oil, by i.g. intubation) 11 times at 2 week intervals starting at week 4 after initial 20 mg/kg DMN i.p. injections at weeks 0 and 2. Sacrifice at week 28 revealed no differences in either hepatocellular or cholangiocellular lesion development between carcinogen-initiated groups with or without antihelminthic treatment. No lesions were observed in the praziquantel alone or untreated groups. The results thus indicate no promotion potential for praziquantel on nitrosamine-induced lesions in the hamster liver.
authors.affiliation: Department of Pathobiology, Faculty of Science, Mahidol University, Bangkok, Thailand.
authors.forename: W
authors.initials: W
authors.lastname: Thamavit
authors.forename: M A
authors.initials: MA
authors.lastname: Moore
authors.forename: S
authors.initials: S
authors.lastname: Ruchirawat
authors.forename: N
authors.initials: N
authors.lastname: Ito
mesh_terms: D000818:Animals; D001835:Body Weight / Q000187:drug effects; D006528:Carcinoma, Hepatocellular / Q000139:chemically induced; D006224:Cricetinae; D004128:Dimethylnitrosamine; D004347:Drug Interactions; D008099:Liver / Q000033:anatomy & histology / Q000187:drug effects; D008114:Liver Neoplasms, Experimental / Q000139:chemically induced*; D008297:Male; D008647:Mesocricetus; D009929:Organ Size / Q000187:drug effects; D011223:Praziquantel / Q000494:pharmacology*
chemical_list: D011223:Praziquantel; D004128:Dimethylnitrosamine