title: The specific plaque hypothesis and the antimicrobial treatment of periodontal disease.
abstract: According to the specific plaque hypothesis a measurable amount of periodontal disease is due to the overgrowth of specific bacterial types. The author advocates the theory and discusses treatment. This includes techniques for diagnosing the predominant bacterial types, antibiotic therapy and the relevance of regular debridement.
authors.affiliation: University of Michigan School of Dentistry, Ann Arbor 48109.
authors.forename: W J
authors.initials: WJ
authors.lastname: Loesche
mesh_terms: D001421:Bacteria, Anaerobic / Q000187:drug effects / Q000302:isolation & purification; D001439:Bacteroides / Q000187:drug effects; D001587:Benzoylarginine-2-Naphthylamide / Q000378:metabolism; D003773:Dental Plaque / Q000382:microbiology*; D006801:Humans; D008795:Metronidazole / Q000494:pharmacology / Q000627:therapeutic use*; D010510:Periodontal Diseases / Q000188:drug therapy* / Q000382:microbiology*; D013144:Spirochaetales / Q000187:drug effects; D014208:Treponema / Q000187:drug effects
chemical_list: D008795:Metronidazole; D001587:Benzoylarginine-2-Naphthylamide