[An analysis of the mechanism of the effect of intragastric calcium and magnesium on the release of gastrin and insulin in dogs].
The experiments have been carried out on four intact awake dogs to study the influence of intragastric introduction of deionized water, 5 mmol/l of calcium and magnesium chloride solutions in a dose of 3 ml/kg on release of gastrin and insulin into blood. It is stated that during the first 4 min after infusion of deionized water the release of gastrin decreases by 89 +/- 32 conventional units (c.u.), CaCl2 exerts a more pronounced inhibitory effect (168 +/- 36 c.u.), while MgCl2, on the contrary, increases the gastrin release by 398 +/- 92 c.u. Atropin (0.03 mg/kg, subcutaneous injection, 10 min before infusion) absolutely takes away the gastrin-stimulating effect of magnesium, but it has almost no influence on the gastrin-inhibitory effect of calcium. The latter can be taken away by 62% by ornid (5 mg/kg subcutaneously, 20 min before infusion). Preliminary anaesthesia of the stomach mucosa by trymecain or novocain absolutely remove the effect of both calcium and magnesium. Insulin release remained significantly unchanged in any series of experiments.
Popovych
I L
IL
Ivasivka
S V
SV
Butusova
I A
IA
D000818:Animals; D001285:Atropine / Q000008:administration & dosage; D001950:Bretylium Tosylate / Q000008:administration & dosage; D002122:Calcium Chloride / Q000008:administration & dosage*; D004285:Dogs; D004347:Drug Interactions; D005215:Fasting; D005260:Female; D005755:Gastrins / Q000097:blood / Q000187:drug effects* / Q000378:metabolism; D007328:Insulin / Q000097:blood / Q000378:metabolism*; D000078790:Insulin Secretion; D015636:Magnesium Chloride / Q000008:administration & dosage*; D008297:Male; D011343:Procaine / Q000008:administration & dosage; D013270:Stomach; D014867:Water
D005755:Gastrins; D007328:Insulin; D015636:Magnesium Chloride; D014867:Water; D011343:Procaine; D001950:Bretylium Tosylate; D001285:Atropine; D002122:Calcium Chloride
Analiz mekhanizmu vplyvu intrahastral'noho kal'tsiiu i mahniiu na vyvil'nennia hastrynu ta insulinu u sobak.