Genetic changes in Morris hepatoma 7777 cells.
Analysis of genetic changes in Morris hepatoma 7777 is described. Three different approaches were applied: DNA and chromosome transfection, karyotype analysis, and Southern hybridization modified by use of PFGE. Changes in the genome of tested cells were identified by PFGE and chromosome transfection. This supports the statement that PFGE is a useful method in transformed cell genome analysis.
Burzyński
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Department of Microbiology and Immunology, Jagellonian University, Kraków, Poland.
Porwit-Bóbr
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D016475:3T3 Cells; D000818:Animals; D015139:Blotting, Southern; D004273:DNA, Neoplasm / Q000235:genetics; D007621:Karyotyping; D008114:Liver Neoplasms, Experimental / Q000235:genetics*; D051379:Mice; D009368:Neoplasm Transplantation; D051381:Rats; D011915:Rats, Inbred BUF; D014162:Transfection; D014407:Tumor Cells, Cultured
D004273:DNA, Neoplasm