title: The histopathological comparison of the results of the intra-arterial injections of propofol and thiopentone in rabbits.
abstract: The results of injections of propofol and thiopentone intra-arterially are compared in rabbits according to histopathological criteries. Thirteen New Zealand type rabbits are used. Two ml of 2.5% Thiopentone and 2 ml of 1% Propofol are administered to the rabbits under anesthesia. Three days after, their ears are amputated and sent to this pathological blind examination. In both groups, we saw neither a morphological change along the vessel walls nor significant bleeding. But between the groups there was a significant difference about oedema. Consequently, 2.5% thiopentone which is routinely used after intra-arterial administration, may be responsible of the gangrenous change but it is discussable and it makes significant oedema in animal models although propofol does not have this effect.
authors.affiliation: Anaesthesiology Department, Gazi University, Medical Faculty, Ankara, Turkey.
authors.forename: A
authors.initials: A
authors.lastname: Babacan
authors.forename: M
authors.initials: M
authors.lastname: Akçabay
authors.forename: O
authors.initials: O
authors.lastname: Uluoğlu
authors.forename: I
authors.initials: I
authors.lastname: Ozkoçak
authors.forename: Y
authors.initials: Y
authors.lastname: Karadenizli
mesh_terms: D000818:Animals; D004431:Ear, External / Q000187:drug effects* / Q000473:pathology; D007269:Injections, Intra-Arterial; D008297:Male; D015742:Propofol / Q000008:administration & dosage*; D011817:Rabbits; D013874:Thiopental / Q000008:administration & dosage*
chemical_list: D013874:Thiopental; D015742:Propofol