Ventricular size and regional cerebral blood flow in schizophrenia: an attempted replication.
We attempted to replicate the finding of Berman et al. (1987) that frontal cortical blood flow correlated inversely with ventricular size in schizophrenia. Computed tomography and high-resolution 99m-Tc-HMPAO single photon emission computed tomography were performed in 25 right-handed chronic schizophrenic men engaged in a word-fluency task. Weak, nonstatistically significant inverse correlations were found between the ventricle-brain ratio (VBR) and frontal cortical blood flow. The VBR was significantly inversely correlated with the ratio of left to right medial frontal blood flow.
Ford
R A
RA
Department of Geriatric Medicine, St. George's Hospital Medical School, London, U.K.
Lewis
S W
SW
Syed
G M
GM
Reveley
A
A
Toone
B K
BK
D000328:Adult; D001921:Brain / Q000098:blood supply*; D002552:Cerebral Ventricles / Q000473:pathology*; D004292:Dominance, Cerebral / Q000502:physiology; D005625:Frontal Lobe / Q000098:blood supply; D006801:Humans; D008297:Male; D015609:Organotechnetium Compounds; D010091:Oximes; D012039:Regional Blood Flow / Q000502:physiology; D012559:Schizophrenia / Q000473:pathology / Q000503:physiopathology*; D012565:Schizophrenic Psychology; D019690:Technetium Tc 99m Exametazime; D015899:Tomography, Emission-Computed, Single-Photon; D014057:Tomography, X-Ray Computed
D015609:Organotechnetium Compounds; D010091:Oximes; D019690:Technetium Tc 99m Exametazime