title: Role of renal arterial pressure in the regulation of extracellular volume in conscious dogs.
abstract: 1. This study in conscious dogs examined the quantitative effects of a reduction in the renal arterial pressure on the renal homeostatic responses to an acute extracellular fluid volume expansion. 2. Seven female beagle dogs were chronically instrumented with two aortic catheters, one central venous catheter and a suprarenal aortic cuff, and were kept under standardized conditions on a constant high dietary sodium intake (14.5 mmol of Na+ day-1 kg-1 body weight). 3. After a 60 min control period, 0.9% (w/v) NaCl was infused at a rate of 1 ml min-1 kg-1 body weight for 60 min (infusion period). Two different protocols were applied during the infusion period: renal arterial pressure was maintained at 102 +/- 1 mmHg by means of a servo-feedback control circuit (RAP-sc, 14 experiments) or was left free (RAP-f, 14 experiments). 4. During the infusion period, in the RAP-sc protocol as well as in the RAP-f protocol, the mean arterial pressure increased by 10 mmHg, the heart rate increased by 20 beats/min, the central venous pressure increased by 4 cmH2O and the glomerular filtration rate (control 5.1 +/- 0.3 ml min-1 kg-1 body weight, mean +/- SEM) increased by 1 ml min-1 kg-1. 5. Plasma renin activity [control 0.85 +/- 0.15 (RAP-f) and 1.08 +/- 0.23 (RAP-sc) pmol of angiotensin I h-1 ml-1] decreased similarly in both protocols.(ABSTRACT TRUNCATED AT 250 WORDS)
authors.affiliation: Clinic of Anaesthesiology and Operative Intensive Medicine, UKRV Charlottenburg, Free University of Berlin, Germany.
authors.forename: G
authors.initials: G
authors.lastname: Kaczmarczyk
authors.forename: K
authors.initials: K
authors.lastname: Schröder
authors.forename: D
authors.initials: D
authors.lastname: Lampe
authors.forename: R
authors.initials: R
authors.lastname: Mohnhaupt
mesh_terms: D000818:Animals; D001794:Blood Pressure / Q000502:physiology; D004285:Dogs; D005110:Extracellular Space / Q000502:physiology*; D005260:Female; D005919:Glomerular Filtration Rate / Q000502:physiology; D006706:Homeostasis / Q000502:physiology; D011188:Potassium / Q000652:urine; D012077:Renal Artery / Q000502:physiology*; D012964:Sodium / Q000008:administration & dosage / Q000652:urine; D014882:Water-Electrolyte Balance / Q000502:physiology
chemical_list: D012964:Sodium; D011188:Potassium