[The clinical assessment of macrophage functional activity in patients with protracted dysentery and its correction with lysozyme and vitamin E].
Prospects for the correction of disturbances in the macrophagal system with a combination of lysozyme and vitamin E in patients with a protracted course of dysentery caused by Shigella flexneri 1b were studied. The phagocytic activity of macrophages (PAM) was found to be suppressed as early as at the beginning of the disease. Out of 38 persons repeatedly found to release shigellae 24 were administered polychemotherapy. PAM indices in patients treated with lysozyme and tocopherol acetate were likely to normalize, this being indicative of the positive effect of these preparations on the functional activity of the macrophagal system.
Iushchuk
N D
ND
Ziuzin
V A
VA
Frolov
V M
VM
Peresadin
N A
NA
D000328:Adult; D000368:Aged; D002908:Chronic Disease; D004341:Drug Evaluation; D004359:Drug Therapy, Combination; D004405:Dysentery, Bacillary / Q000188:drug therapy / Q000276:immunology*; D005260:Female; D006801:Humans; D008264:Macrophages / Q000187:drug effects / Q000276:immunology*; D008297:Male; D008875:Middle Aged; D009113:Muramidase / Q000627:therapeutic use*; D010587:Phagocytosis / Q000187:drug effects; D012763:Shigella flexneri; D014810:Vitamin E / Q000627:therapeutic use*
D014810:Vitamin E; D009113:Muramidase
Klinicheskaia otsenka funktsional'noĭ aktivnosti makrofagov u bol'nykh zatiazhnoĭ dizenterieĭ i ee korrektsiia lizotsimom i vitaminom E.