Model of distribution of anticancer agents transplanted into the brain tissue using the random walk method.
A Monte-Carlo approach to analysis of dispersion in the tissue of a locally administered drug is presented. The distribution of a drug in the tissue is simulated as a distribution of randomly walking particles. The approach is demonstrated on a simple situation for which both experimental results and an analytical solution are known. The approach can be used in situations, where common numeric methods are difficult to use, especially for analyses of drug transport in an inhomogeneous space, and problems with complex boundary conditions, e.g. in analyses of dispersion of anticancer agents locally applied into tumours.
Polák
J
J
Institute of Preventive and Clinical Medicine, Bratislava, Czecho-Slovakia.
Kvasnicka
P
P
Chorvát
D
D
Kállay
Z
Z
D000818:Animals; D000970:Antineoplastic Agents / Q000008:administration & dosage / Q000493:pharmacokinetics*; D001693:Biological Transport, Active; D001932:Brain Neoplasms / Q000188:drug therapy* / Q000378:metabolism*; D002945:Cisplatin / Q000008:administration & dosage / Q000493:pharmacokinetics; D007263:Infusions, Parenteral; D008954:Models, Biological; D009010:Monte Carlo Method; D051381:Rats; D014018:Tissue Distribution
D000970:Antineoplastic Agents; D002945:Cisplatin