title: [The effect of ubiquinone-10 on the development of D-galactosamine-induced hepatitis in rats].
abstract: It has been shown that prophylactic administration of ubiquinone protects rats liver from the toxic damage by D-galactosamine both on ultrastructural and on cell levels. Ubiquinone administration prevents necrosis in hepatocytes and preserves their ability for compensatory reactions expressed in activation of protein-synthesis regulating structures in the cell. Ubiquinone decreases hyperfermentemia and hyperbilirubinemia as well as prevents the decrease in liver protein content caused by galactosamine. Ubiquinone exerts an antioxidant effect, blocking the induction of lipid peroxidation both in intact and hepatic rats.
authors.forename: N P
authors.initials: NP
authors.lastname: Sugrobova
authors.forename: R S
authors.initials: RS
authors.lastname: Medvednik
authors.forename: L V
authors.initials: LV
authors.lastname: Efimova
authors.forename: T V
authors.initials: TV
authors.lastname: Katarzhnova
authors.forename: A E
authors.initials: AE
authors.lastname: Liubarev
authors.forename: V M
authors.initials: VM
authors.lastname: Shaposhnikov
authors.forename: E A
authors.initials: EA
authors.lastname: Obol'nikova
authors.forename: A A
authors.initials: AA
authors.lastname: Poznanskaia
mesh_terms: D000818:Animals; D056486:Chemical and Drug Induced Liver Injury / Q000201:enzymology / Q000209:etiology / Q000473:pathology / Q000517:prevention & control*; D004195:Disease Models, Animal; D004353:Drug Evaluation, Preclinical; D005688:Galactosamine; D008099:Liver / Q000187:drug effects / Q000201:enzymology / Q000648:ultrastructure; D008297:Male; D008854:Microscopy, Electron; D051381:Rats; D014451:Ubiquinone / Q000627:therapeutic use*
chemical_list: D014451:Ubiquinone; D005688:Galactosamine; C025204:Ubiquinone Q2
vernacular_title: Vliianie ubikhinona-10 na razvitie D-galaktozaminovogo gepatita u krys.