Detection of hepatitis C virus RNA in chronic non-A, non-B liver disease.
Serum samples were tested for detection of hepatitis C virus (HCV) RNA from 156 patients with chronic non-A, non-B liver disease. HCV RNA was detected in 121 (93.8%) of 129 patients positive for anti-C100-3 but was also found in 15 (55.6%) of 27 patients negative for anti-C100-3. The rate of positivity for HCV RNA was not significantly different among various stages of liver diseases. These results showed that HCV continues to replicate even in advanced liver disease and that it seems to be related to half of the cases of chronic non-A, non-B liver disease negative for anti-C100-3.
Hagiwara
H
H
First Department of Medicine, Osaka University Medical School, Japan.
Hayashi
N
N
Mita
E
E
Hiramatsu
N
N
Ueda
K
K
Takehara
T
T
Yuki
N
N
Kasahara
A
A
Fusamoto
H
H
Kamada
T
T
D000328:Adult; D000368:Aged; D000956:Antigens, Viral; D001483:Base Sequence; D002908:Chronic Disease; D016174:Hepacivirus / Q000235:genetics / Q000302:isolation & purification*; D006508:Hepatitis Antibodies / Q000097:blood; D006526:Hepatitis C / Q000175:diagnosis*; D018937:Hepatitis C Antibodies; D006801:Humans; D008875:Middle Aged; D008969:Molecular Sequence Data; D012367:RNA, Viral / Q000097:blood*; D017361:Viral Nonstructural Proteins; D014764:Viral Proteins / Q000276:immunology
D000956:Antigens, Viral; C064544:C100 protein, hepatitis C virus; D006508:Hepatitis Antibodies; D018937:Hepatitis C Antibodies; D012367:RNA, Viral; D017361:Viral Nonstructural Proteins; D014764:Viral Proteins; C078224:anti-C100-3