[The effect of the delta sleep-inducing peptide on the development of toxic brain edema-swelling].
Antiedematic effects of the drugs are connected with their action on the mediator systems. DSIP has a wide range of modulatory effects on the brain mediator systems. DSIP antiedematic effect was studied on the toxic brain edema-swelling (BES) model. Physical characteristics of the nervous tissue such as thickness and wetness were used as evaluation criteria. According to the findings, the doses of 75-100 micrograms/kg DSIP were optimal. It is suggested that DSIP effect on BES is multicomponent and rather complicated. Inhibition of serotonin, noradrenaline and histamine systems and activation of GABA-ergic system by DSIP act as a possible antiedematic mechanism.
Platonov
I A
IA
Iasnetsov
V V
VV
D000818:Animals; D001929:Brain Edema / Q000139:chemically induced / Q000517:prevention & control*; D003701:Delta Sleep-Inducing Peptide / Q000627:therapeutic use*; D004305:Dose-Response Relationship, Drug; D004353:Drug Evaluation, Preclinical; D009538:Nicotine; D051381:Rats; D017208:Rats, Wistar
D003701:Delta Sleep-Inducing Peptide; D009538:Nicotine
Vliianie peptida, vyzyvaiushchego del'ta-son, na razvitie toksicheskogo oteka-nabukhaniia golovnogo mozga.