[The effect of amiridin on the MPTP-induced Parkinson-like syndrome in monkeys].
Development of behavioral disturbances was investigated during N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) administration (0,2 mg/kg, i/m, at 48 h. intervals, total dose 11.2-13.2 mg/kg) in experiments on two monkeys Macaca rhesus. MPTP induced the complex of symptoms, which are typical for idiopathic Parkinson's disease. Administration of amiridine (0,25-0,4 mg/kg) to MPTP-treated monkeys caused gradual decline of Parkinson syndrome. Mechanisms of action of amiridine are discussed.
Burov
Iu V
IuV
Metkalova
S E
SE
Kustov
A E
AE
Petrov
G V
GV
Shul'govskiĭ
V V
VV
D015632:1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; D000634:Aminoquinolines / Q000627:therapeutic use*; D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects; D002800:Cholinesterase Inhibitors; D004195:Disease Models, Animal; D004353:Drug Evaluation, Preclinical; D005260:Female; D008253:Macaca mulatta; D008297:Male; D010302:Parkinson Disease, Secondary / Q000139:chemically induced / Q000188:drug therapy*; D011619:Psychotropic Drugs / Q000627:therapeutic use*; D013997:Time Factors
D000634:Aminoquinolines; D002800:Cholinesterase Inhibitors; D011619:Psychotropic Drugs; D015632:1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; C049860:amiridine
Vliianie amiridina na MFTP-indutsirovannyĭ parkinsonpodobnyĭ sindrom u obez'ian.