title: [Expression of angiotensin II receptor on BALF macrophages from patients with sarcoidosis and healthy individuals].
abstract: We previously reported that angiotensin II (A-II) enhanced the accessory function of BALF macrophages in some patients with sarcoidosis. We hypothesized that this finding was mediated by the A-II receptor on BALF macrophages. From this viewpoint, we investigated the expression of A-II receptor on BALF macrophages. The binding of 125I-A-II to BALF macrophages was specifically inhibited by unlabeled A-II when incubated for 1 hour at 37 degrees C. However, the uptake of 3H-inulin to BALF macrophages was not inhibited by unlabeled inulin under the same conditions. These findings indicate that the binding of 125I-A-II to BALF macrophages was mediated by the putative A-II receptor, and was not due to pinocytosis.
authors.affiliation: Second Department of Medicine, Kyoto University, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Takeuchi
authors.forename: H
authors.initials: H
authors.lastname: Nakada
authors.forename: S
authors.initials: S
authors.lastname: Nagai
mesh_terms: D000328:Adult; D000804:Angiotensin II / Q000378:metabolism*; D002478:Cells, Cultured; D006801:Humans; D016676:Macrophages, Alveolar / Q000378:metabolism*; D008875:Middle Aged; D011945:Receptors, Angiotensin / Q000378:metabolism*; D012507:Sarcoidosis / Q000378:metabolism*
chemical_list: D011945:Receptors, Angiotensin; D000804:Angiotensin II