Polyclonal origin of rheumatoid synovial T-lymphocytes.
Nineteen T-cell clones from seven patients with RA were obtained by cloning infiltrating lymphocytes from needle synovial biopsies. Southern blot analysis of the T-cell receptor (TCR) beta-chain genes in these clones revealed that there were no T-cell clones with an identical rearrangement of the TCR beta gene. These results do not support the idea that the infiltrating T-lymphocytes in RA are of monoclonal or oligoclonal origin.
Hylton
W
W
MRC Clinical Research Centre, Harrow, Middlesex.
Smith-Burchnell
C
C
Pelton
B K
BK
Palmer
R G
RG
Denman
A M
AM
Malkovsky
M
M
D001172:Arthritis, Rheumatoid / Q000235:genetics / Q000473:pathology*; D002460:Cell Line; D002999:Clone Cells; D005260:Female; D015333:Gene Rearrangement, beta-Chain T-Cell Antigen Receptor; D006801:Humans; D008297:Male; D013583:Synovial Membrane / Q000473:pathology*; D013601:T-Lymphocytes / Q000473:pathology*