Analytical comparison of an enzyme-amperometric method for chlorocresol determination in ointments with colorimetry and liquid chromatography.
The direct determination of chlorocresol in n-hexane extracts of commercial ointments was successfully performed using an enzyme-amperometric probe for analysis of phenols and working in previously characterized and optimized non-aqueous solvents. The analytical data obtained were compared with those found by using classical HPLC or chemical spectrophotometric method for determination of phenols.
Campanella
L
L
Dipartimento di Chimica, Università di Roma La Sapienza, Italy.
Sammartino
M P
MP
Sbrilli
R
R
Tomassetti
M
M
D015374:Biosensing Techniques; D002626:Chemistry, Pharmaceutical / Q000379:methods*; D002851:Chromatography, High Pressure Liquid; D002853:Chromatography, Liquid; D003124:Colorimetry; D003408:Cresols / Q000032:analysis*; D004800:Enzymes, Immobilized; D006586:Hexanes / Q000737:chemistry; D009824:Ointments / Q000737:chemistry*; D013056:Spectrophotometry, Ultraviolet
D003408:Cresols; D004800:Enzymes, Immobilized; D006586:Hexanes; D009824:Ointments; C026385:n-hexane; C006984:chlorocresol