Protective action of vitamin E on the subcellular structures of lymphocytes intoxicated with pesticides in vitro.
Vitamin E was used as a protection for human lymphocytes in vitro against the toxic effects of dichlorvos, an organic phosphate pesticide. As the markers of the toxic changes in the lymphocytes lysosomes were chosen as a membrane structure, and nucleoli as a structure connected with protein synthesis. The obtained results were compared with the effects obtained previously in analogous studies after intoxication of lymphocytes with lindan and fenarimol. The experiment showed that vitamin E protected the lysosomal membranes more effectively than the nucleolar structure in these cells.
Grabarczyk
M
M
Department of Physiopathology, Institute of Haematology and Blood Transfusion, Warsaw.
Kopeć-Szlezak
J
J
D002466:Cell Nucleolus / Q000187:drug effects; D004006:Dichlorvos / Q000633:toxicity*; D006801:Humans; D008214:Lymphocytes / Q000187:drug effects* / Q000648:ultrastructure; D008247:Lysosomes / Q000187:drug effects; D014810:Vitamin E / Q000494:pharmacology*
D014810:Vitamin E; D004006:Dichlorvos