[Antioxidant agents--importance in neonatology].
The toxic consequences of oxygen therapy may be development some neonatal diseases, for example: retrolental fibroplasia and bronchopulmonary dysplasia. It's now generally believed that oxygen induced cell toxicity is the result of formation of highly reactive free radicals. The greater incidence of these disorders in preterm infants suggest that some aspect of prematurity increases susceptibility of effects of toxic oxygen species. It's proposed the term for these disorders: "oxygen radical diseases of prematurity". Verification of the hypothesis about role of the antioxidant defense mechanisms of neonate may have important implications in the pursuit of the etiology these diseases and in identification of agents that may minimize toxicity associated with oxygen therapy.
Królak
B
B
Katedry i Kliniki Połoznictwa i Rozrodczości, Zabrzu.
Kamiński
K
K
Olech-Jedlikowska
K
K
D000975:Antioxidants / Q000627:therapeutic use*; D006801:Humans; D007231:Infant, Newborn; D007235:Infant, Premature, Diseases / Q000209:etiology / Q000517:prevention & control*; D010102:Oxygen Inhalation Therapy / Q000009:adverse effects*
D000975:Antioxidants
Układy antyoksydacyjne--znaczenie w neonatologii.