title: Fetal malformations associated with chronic polyhydramnios in singleton pregnancies.
abstract: Forty-one congenital malformations were found in 28 newborns in a group of 197 cases of chronic polyhydramnios in singleton pregnancies. Of these, a total of 61% (17/28) was antenatally diagnosed ultrasonically. Nine newborns (4.5%) had malformations of the central nervous system (CNS), 9 (4.5%) cardiovascular malformations, 8 (4.1%) musculoskeletal anomalies, 7 (3.6%) malformations of the urinary and reproductive system, 4 (2%) respiratory system anomalies and 3 (1.6%) anomalies of the gastrointestinal system. Chromosomal abnormalities were found in three cases. As the association of polyhydramnios with fetal congenital anomalies is quite high (14.2% in our series), it is imperative to make a major effort to antenatally detect as many cases as possible. This means that in the case of hydramnios the following are required: ultrasound examination by an expert, echo ultrasonography when no other abnormalities are detected, and maybe even a chromosomal analysis.
authors.affiliation: Department of Obstetrics and Gynecology B, Serlin Maternity Hospital, Tel-Aviv Medical Center, Israel.
authors.forename: A
authors.initials: A
authors.lastname: Golan
authors.forename: I
authors.initials: I
authors.lastname: Wolman
authors.forename: R
authors.initials: R
authors.lastname: Langer
authors.forename: M P
authors.initials: MP
authors.lastname: David
mesh_terms: D001921:Brain / Q000002:abnormalities; D002908:Chronic Disease; D005260:Female; D005333:Fetus / Q000002:abnormalities*; D006330:Heart Defects, Congenital / Q000209:etiology; D006801:Humans; D017880:Limb Deformities, Congenital; D006831:Polyhydramnios / Q000150:complications*; D011247:Pregnancy; D016216:Ultrasonography, Prenatal