title: Interleukin-6 and granulocyte macrophage-CSF in the cerebrospinal fluid from HIV infected subjects with involvement of the central nervous system.
abstract: We detected the cytokines interleukin-6 (IL-6) and granulocyte macrophage-CSF (GM-CSF) by ELISA in the CSF and serum of 30 HIV-infected patients classified as AIDS dementia complex (ADC), and 20 subjects with other neurological diseases (OND). We have found a high incidence of detectable IL-6 and GM-CSF in the CSF of ADC patients compared with OND patients. No statistical differences were observed between both groups for serum IL-6 and GM-CSF levels. These results suggest an intrathecal synthesis of these cytokines and a possible involvement in the pathogenesis of ADC.
authors.affiliation: D. Cotugno Hospital for Infectious Diseases, Naples.
authors.forename: O
authors.initials: O
authors.lastname: Perrella
authors.forename: M
authors.initials: M
authors.lastname: Guerriero
authors.forename: E
authors.initials: E
authors.lastname: Izzo
authors.forename: M
authors.initials: M
authors.lastname: Soscia
authors.forename: P B
authors.initials: PB
authors.lastname: Carrieri
mesh_terms: D015526:AIDS Dementia Complex / Q000097:blood / Q000134:cerebrospinal fluid*; D000328:Adult; D002493:Central Nervous System Diseases / Q000097:blood / Q000134:cerebrospinal fluid; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D016178:Granulocyte-Macrophage Colony-Stimulating Factor / Q000097:blood / Q000134:cerebrospinal fluid*; D006801:Humans; D015850:Interleukin-6 / Q000097:blood / Q000134:cerebrospinal fluid*; D008297:Male
chemical_list: D015850:Interleukin-6; D016178:Granulocyte-Macrophage Colony-Stimulating Factor