title: [Prognostic value of an early peak CK-MB in plasma of patients treated with streptokinase for acute myocardial infarction].
abstract: 111 patients below 70 years old, with the first acute myocardial infarctions, 6 hours since the pain occurred--have been treated with streptokinase i.v. In 102 patients we obtained full curve of CK-MB activity. Early peak of CK-MB activity < 15 hours after onset of symptoms we have observed in 59 patients, and late peak of CK-MB activity > 15 hours in 43 patients. There was not any significant statistics differences between early and late groups in frequency of: early ventricular fibrillation (< 48 hours), complex ventricular arrhythmia (in 21 day), heart failure and in-hospital mortality. 1 patient died in hospital in early group and in late group also died 1 patient. The follow-up period was from 10 to 48 months (av. 26 +/- 13). 100 patients left the hospital and the full informations we have obtained in 97 cases. No one died in that time. In the group with early peak CK-MB activity we observed more often the unstable angina and the new myocardial infarction (21%) than in the group with late peak of CK-MB activity (15%), but these differences were nonsignificant. In conclusion our results don't confirm that the early peak of CK-MB activity is the positive risk factor of unstable angina and the new myocardial infarction.
authors.affiliation: Kliniki Kardiologii Instytutu Chorób Wewnetrznych AM, Warszawie.
authors.forename: J
authors.initials: J
authors.lastname: Stanisławska
authors.forename: G
authors.initials: G
authors.lastname: Opolski
authors.forename: K
authors.initials: K
authors.lastname: Słomka
authors.forename: M
authors.initials: M
authors.lastname: Niemczyk
authors.forename: A
authors.initials: A
authors.lastname: Górecki
authors.forename: W
authors.initials: W
authors.lastname: Tadeusiak
authors.forename: T
authors.initials: T
authors.lastname: Kraska
mesh_terms: D000328:Adult; D000368:Aged; D003402:Creatine Kinase / Q000097:blood*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007527:Isoenzymes; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000188:drug therapy* / Q000201:enzymology; D011379:Prognosis; D013300:Streptokinase / Q000627:therapeutic use*
chemical_list: D007527:Isoenzymes; D003402:Creatine Kinase; D013300:Streptokinase
vernacular_title: Wartość prognostyczna wczesnego szczytu aktywności CK-MB w surowicy u chorych leczonych streptokinaza w ostrym zawale serca.