Analysis of factors influencing the efficacy of pooled platelet transfusions.
The results of 839 platelet transfusions in 115 patients were studied to establish the relative importance of 10 clinical factors in determining the efficacy of pooled donor transfusions. Efficacy was measured by the one hour corrected increment in platelet count. The number of transfusions available for study from individual patients varied widely from 1 to 37. Two methods of analysis are presented. The first makes assumptions about the correlation between transfusions within patients, and the variation between patients. The second is based on a repeated sampling procedure whereby unbiased estimates of the parameters of interest are obtained from random samples containing only one transfusion per patient.
Matthews
J P
JP
Statistical Centre, Peter MacCallum Cancer Institute, Melbourne, Australia.
Yuen
K
K
D015982:Bias; D016913:Blood Component Transfusion / Q000592:standards*; D003627:Data Interpretation, Statistical; D006801:Humans; D016013:Likelihood Functions; D016014:Linear Models; D010976:Platelet Count; D011446:Prospective Studies