Synthesis and central pharmacological screening of new aminoalkoxy derivatives of coumarin and chromene.
Several 8-(2- and 3-aminoalkoxy) derivatives of coumarin and 5-(2- and 3-aminoalkoxy) derivatives of chromene have been synthesized. The strongest, although short-time neurodepressive activity was exhibited by 8-[3-(4-phenyl-1-piperazinyl)propoxy]-7-methoxycoumarin hydrochloride 15.
Suski
S
S
Department of Chemistry, Medical Academy, Warszawa, Poland.
Zawadowski
T
T
Bogdal
M
M
Przemyk
B
B
Szafrański
B
B
D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects*; D002490:Central Nervous System / Q000187:drug effects*; D002839:Chromans / Q000494:pharmacology* / Q000633:toxicity; D003374:Coumarins / Q000138:chemical synthesis / Q000494:pharmacology* / Q000633:toxicity; D004195:Disease Models, Animal; D004353:Drug Evaluation, Preclinical; D007035:Hypothermia / Q000188:drug therapy; D051379:Mice; D009043:Motor Activity / Q000187:drug effects; D010879:Piperazines / Q000138:chemical synthesis / Q000494:pharmacology* / Q000633:toxicity; D011619:Psychotropic Drugs / Q000138:chemical synthesis / Q000494:pharmacology* / Q000633:toxicity; D051381:Rats; D012890:Sleep / Q000187:drug effects; D013239:Stereotyped Behavior / Q000187:drug effects
D002839:Chromans; D003374:Coumarins; D010879:Piperazines; D011619:Psychotropic Drugs; C080471:8-(3-(4-phenyl-1-piperazinyl)propoxy)-7-methoxycoumarin