Influence of cloprostenol in the experimentally induced ulcer in rats.
We have tested the action of cloprostenol a relatively stable analogue of PGF2 alpha in experimentally induced gastric ulcer in rats by contention stress or indomethacin. Our results show that CIPG, administered at higher doses than those inducing an luteolytic effect, has a gastroprotective effect both in the contention stress-induced ulcer (2.30 + 0.26 in series III as compared to 3.80 +/- 0.73 in series III, p < 0.01) and in indomethacin-induced ulcer (2.69 +/- 0.38 in series V as compared to 3.61 +/- 0.34 in series IV, p < 0.01).
Neughebauer
B I
BI
Department of Pharmacology, University Medical School of Iasi, Romania.
Nechifor
M
M
Dobrescu
G
G
Negru
A
A
Adomnicăi
M
M
D000818:Animals; D003008:Cloprostenol / Q000627:therapeutic use*; D004195:Disease Models, Animal; D004353:Drug Evaluation, Preclinical; D007213:Indomethacin; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D013276:Stomach Ulcer / Q000188:drug therapy* / Q000209:etiology; D013315:Stress, Psychological / Q000150:complications
D003008:Cloprostenol; D007213:Indomethacin