title: [Neonatal heart transplantation. First results].
abstract: Two 5- and 17-days old neonates with hypoplastic left heart syndrome respectively underwent orthotopic heart transplantation. The donor-recipient weight ratio was +58 percent and +88 percent; ischemic time was 144 and 167 min. The immunosuppressive protocol included thymoglobulin during the induction period and a classical 3-drug therapy, with a rapid tapering off of prednisone over 3 weeks. No infectious complication was observed; each infant experimented one episode of acute rejection, successfully treated with prednisolone. Forty-three months and 10 months later, the 2 children are doing well, with normal renal function and normal growth. No late rejection episode was observed. Heart transplantation in neonates is feasible, the short-term and mid-term results are good. Despite important ethical problems, heart transplantation represents a great hope for neonates with inoperable congenital heart defects.
authors.affiliation: Centre Chirurgical Marie-Lannelongue, Université Paris-Sud, France.
authors.forename: L
authors.initials: L
authors.lastname: Houyel
authors.forename: J
authors.initials: J
authors.lastname: Petit
authors.forename: J
authors.initials: J
authors.lastname: Losay
authors.forename: A
authors.initials: A
authors.lastname: Touchot-Kone
authors.forename: J
authors.initials: J
authors.lastname: Bruniaux
authors.forename: G
authors.initials: G
authors.lastname: Blaysat
authors.forename: P
authors.initials: P
authors.lastname: Morville
authors.forename: A
authors.initials: A
authors.lastname: Serraf
authors.forename: F
authors.initials: F
authors.lastname: Lacour-Gayet
authors.forename: C
authors.initials: C
authors.lastname: Planché
mesh_terms: D006084:Graft Rejection / Q000188:drug therapy / Q000209:etiology; D006330:Heart Defects, Congenital / Q000601:surgery*; D016027:Heart Transplantation / Q000009:adverse effects / Q000379:methods*; D006801:Humans; D007231:Infant, Newborn; D011239:Prednisolone / Q000627:therapeutic use
chemical_list: D011239:Prednisolone
vernacular_title: Transplantation cardiaque néonatale. Premiers résultats.