title: Calcium oscillations in single isolated human vascular smooth muscle cells.
abstract: When cultured human vascular smooth muscle cells are exposed to sodium-free solutions oscillations in intracellular calcium concentration are observed. In some cells the oscillations are maintained at constant amplitude throughout the exposure to Na(+)-free solution, in others the amplitude of the oscillations falls to a lower, steady-state level. The oscillations are also activated and maintained in isotonic, Na(+)-free, K+ solutions suggesting that the underlying mechanism does not involve the opening and closing of voltage-dependent channels. The possible mechanisms responsible for this behaviour are discussed.
authors.affiliation: Department of Physiological Sciences Medical School, The University, Newcastle upon Tyne.
authors.forename: H
authors.initials: H
authors.lastname: Otun
authors.forename: J I
authors.initials: JI
authors.lastname: Gillespie
authors.forename: J R
authors.initials: JR
authors.lastname: Greenwell
authors.forename: W
authors.initials: W
authors.lastname: Dunlop
mesh_terms: D002118:Calcium / Q000378:metabolism*; D015220:Calcium Channels / Q000378:metabolism; D002478:Cells, Cultured; D006801:Humans; D009131:Muscle, Smooth, Vascular / Q000187:drug effects / Q000378:metabolism*; D011188:Potassium / Q000494:pharmacology; D012964:Sodium / Q000494:pharmacology
chemical_list: D015220:Calcium Channels; D012964:Sodium; D011188:Potassium; D002118:Calcium