title: [The limits of hormone substitution in pollutant exposure and fertility disorders].
abstract: Heavy metals and chloro-organic compounds can influence female fertility at every phase of reproduction. They may induce hormonal disorders, preventing ovulations and pregnancies. They can also result in abortions and fetal malformations. For this reason, the urinary excretion of heavy metals was measured after oral load with the chelating agent dimercaptopropanesulfonate (Dimaval) in women with hormonal irregularities. In addition, blood was examined for various polychlorinated compounds (polychlorinated biphenyls - PCB -, hexachlorocyclohexane - HCH -, pentachlorophenole - PCP -, hexachlorobenzol - HCB -, dichlordiphenyltrichloroethane - DDT -, dichlorodiphenylethane - DDE -, tetrachlorodiphenylethane - DDD -). Mercury contaminations were seen most commonly and correlated significantly with the number of amalgam fillings and with the release of mercury while chewing. The latter was demonstrated with the so-called chewing-gum test. Women with hormonal disorders or alopecia had, on the average, the highest mercury excretion during the wash-out test. Cadmium excretion was pronounced for the following groups of women: those with technical professions, those suffering from thyroid dysfunctions, and those with habitual abortions and uterine fibroids. With increasing age, pesticide concentrations of the blood rose significantly. Women with endometriosis and with antihyroidal antibodies had significantly higher PCB values. Despite therapeutic intervention, fewer women with elevated DDT/DDE/DDD values conceived when compared to those with lower values. alpha-HCH concentrations were often elevated in women with uterine fibroids. With increasing PCP levels pregnancies often ended in abortion. Results of this investigation indicate that women with hormonal irregularities or specific fertility disorders should be examined for heavy metal and pesticide contamination prior to hormone treatment.
authors.affiliation: Abteilung für Gynäkologische Endokrinologie und Fertilitätsstörungen, Universitätsfrauenklinik Heidelberg.
authors.forename: I
authors.initials: I
authors.lastname: Gerhard
authors.forename: B
authors.initials: B
authors.lastname: Runnebaum
mesh_terms: D000328:Adult; D004785:Environmental Pollutants / Q000009:adverse effects* / Q000493:pharmacokinetics; D005260:Female; D012739:Gonadal Steroid Hormones / Q000502:physiology*; D006801:Humans; D007247:Infertility, Female / Q000139:chemically induced* / Q000188:drug therapy; D011247:Pregnancy; D014131:Trace Elements / Q000008:administration & dosage*; D014815:Vitamins / Q000008:administration & dosage*
chemical_list: D004785:Environmental Pollutants; D012739:Gonadal Steroid Hormones; D014131:Trace Elements; D014815:Vitamins
vernacular_title: Grenzen der Hormonsubstitution bei Schadstoffbelastung und Fertilitätsstörungen.