[Effect of intermittent normobaric hypoxic activity on the development of acute radiation disease].
The experiments on 260 male mice of colony SHK, 352 mongrel rats and 20 Wistar rats were carried out to study the ability of using the normobaric hypoxic stimulation method for acute radiation sickness. Hypoxic stimulation using gas mixture with 10% of oxygen and 90% of nitrogen was conducted for two weeks after irradiation for 30 min. every day. It is shown that under influence of ionizing radiation (7 and 5.5 Gy) the postradiation hypoxic action increased the 30-day survival rate of mice, reduced disturbances of the qualitative composition of leukocytes in peripheric blood, promoted more rapid restoration of thromboelastography indices and caused no reliable changes in the postradial content of albumin and creatinine in blood.
Sobolev
A A
AA
Strelkov
R B
RB
D000208:Acute Disease; D000818:Animals; D001792:Blood Platelets; D003404:Creatinine / Q000097:blood; D007958:Leukocyte Count; D008297:Male; D051379:Mice; D009584:Nitrogen / Q000627:therapeutic use; D010100:Oxygen / Q000627:therapeutic use; D011833:Radiation Injuries, Experimental / Q000097:blood / Q000401:mortality / Q000628:therapy*; D051381:Rats; D017208:Rats, Wistar; D012138:Respiratory Therapy; D012709:Serum Albumin; D015996:Survival Rate; D013997:Time Factors
D012709:Serum Albumin; D003404:Creatinine; D009584:Nitrogen; D010100:Oxygen
Vliianie preryvistogo normobaricheskogo gipoksicheskogo vozdeĭstviia na razvitie ostroĭ luchevoĭ bolezni.