Antitumor activity of new antitumor substance, polyoxomolybdate, against several human cancers in athymic nude mice.
Antitumor polyoxomolybdates have been recognized in the course of study on the medical utilization of polyoxometalates, inorganic polymers of metal oxide. [NH3Pri]6[Mo7O24].3H2O (PM-8) was found as a representative of antitumor polyoxomolybdates. The growth suppressions of PM-8 against Co-4 human colon cancer xenografted under the subrenal capsule in cd-1 mice were equal or superior to that of 5-FU, MMC, ACNU, ADM and CDDP. Potent antitumor activity of PM-8 is also established against MX-1 human breast and OAT human lung cancer xenografted in athymic nude mice. Polyoxomolybdate is a new type of antitumor substance.
Fujita
H
H
Division of Chemotherapy, Keio University, Tokyo, Japan.
Fujita
T
T
Sakurai
T
T
Yamase
T
T
Seto
Y
Y
D000818:Animals; D001943:Breast Neoplasms / Q000188:drug therapy* / Q000473:pathology; D003110:Colonic Neoplasms / Q000188:drug therapy* / Q000473:pathology; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000188:drug therapy* / Q000473:pathology; D051379:Mice; D008819:Mice, Nude; D008958:Models, Molecular; D008982:Molybdenum / Q000627:therapeutic use*; D009368:Neoplasm Transplantation; D010087:Oxides / Q000627:therapeutic use*; D013370:Subrenal Capsule Assay
D010087:Oxides; C081971:PM 8; D008982:Molybdenum