Morphohistochemical characterization of suramin--induced chronic toxicity in rat kidney.
The effects of a chronic administration of suramin were evaluated on renal parenchyma of young rats. Animals were given suramin 18 mg/kg i.p. twice a week for two months, a treatment schedule equivalent to that used in cancer patients. At the end of the treatment, suramin concentrations in plasma and kidney were assayed and a morphohistochemical examination of renal parenchyma was carried out. Marked and widespread alterations were detected in both cortex and medulla and were associated with elevated tissue suramin levels exceeding 5 mg/g of tissue. The present data demonstrate that suramin induces a severe chronic renal damage in the rat, associated with high drug tissue levels.
Soldani
P
P
Istituto di Anatomia Umana Normale, Università di Pisa, Italy.
Danesi
R
R
Ricciardi
M P
MP
Pellegrini
A
A
Natale
G
G
Paparelli
A
A
D000818:Animals; D004334:Drug Administration Schedule; D005260:Female; D007674:Kidney Diseases / Q000139:chemically induced* / Q000473:pathology; D051381:Rats; D017208:Rats, Wistar; D013498:Suramin / Q000008:administration & dosage / Q000633:toxicity*
D013498:Suramin