title: Clinical evaluation of calcium-antagonist drugs.
abstract: Calcium-antagonist drugs are therapeutic agents of first choice in patients with coronary artery disease. We have reviewed a number of clinical trials in which the safety and efficacy of calcium blockers have been tested and discuss the established clinical effects of these compounds, which range from relief of angina and improved quality of life (both in patients with ischemia due to reduction in coronary flow and in patients with ischemia due to increased O2 demand) to a favorable effect on the course of coronary atherosclerosis and, finally, (at least for some of these agents) to an improvement in prognosis.
authors.affiliation: Dipartimento di Medicina Interna, Università di Pavia, Italy.
authors.forename: S
authors.initials: S
authors.lastname: Ghio
authors.forename: G
authors.initials: G
authors.lastname: Specchia
mesh_terms: D000787:Angina Pectoris / Q000188:drug therapy; D002121:Calcium Channel Blockers / Q000627:therapeutic use*; D003324:Coronary Artery Disease / Q000188:drug therapy; D003327:Coronary Disease / Q000188:drug therapy* / Q000523:psychology; D006801:Humans; D011379:Prognosis; D011788:Quality of Life
chemical_list: D002121:Calcium Channel Blockers