Chronic Pseudomonas aeruginosa endobronchitis in rhesus monkeys: I. Effects of pentoxifylline on neutrophil influx.
Host defense abnormalities in cystic fibrosis (CF) against Pseudomonas aeruginosa (PA) lead to excessive neutrophil influx into the infected lungs, resulting in pulmonary complications. We have developed a rhesus monkey model of chronic PA endobronchitis by intrabronchial instillation of PA-embedded agar beads, utilizing flexible fiberoptic bronchoscopy. Treatment of infected monkeys with pentoxifylline suppressed neutrophil influx and ameliorated pulmonary damage. The results suggest a method by which neutrophil influx and pulmonary damage in CF patients can be managed or prevented.
Cheung
A T
AT
Department of Medical Pathology, University of California, Davis.
Moss
R B
RB
Leong
A B
AB
Novick
W J
WJ
D000818:Animals; D001991:Bronchitis / Q000150:complications / Q000188:drug therapy* / Q000473:pathology; D001992:Bronchoalveolar Lavage Fluid / Q000473:pathology; D002908:Chronic Disease; D003550:Cystic Fibrosis / Q000150:complications; D004195:Disease Models, Animal; D008168:Lung / Q000473:pathology; D008253:Macaca mulatta; D009504:Neutrophils / Q000187:drug effects / Q000473:pathology; D010431:Pentoxifylline / Q000627:therapeutic use*; D011552:Pseudomonas Infections / Q000150:complications / Q000188:drug therapy* / Q000473:pathology
D010431:Pentoxifylline