Virulence factors in Serratia marcescens: cell-bound hemolysin and aerobactin.
1. A total of 60 nosocomial isolates of Serratia marcescens were screened for the presence of markers related to virulence, i.e., cell-bound hemolysin and production of siderophore aerobactin. 2. No aerobactin-producing strains were found, and the incidence of cell-bound hemolysin was 97%. 3. Hemolysin-positive (58 strains) and hemolysin-negative (2 strains) Serratia marcescens showed the same LD50 (3 x 10(7) bacteria) in a test of virulence for mice. 4. These results indicate that cell-bound hemolysin is not a main factor of virulence for mice in Serratia marcescens.
Carbonell
G V
GV
Departamento de Patologia Geral, Universidade Estadual de Londrina, PR, Brasil.
Vidotto
M C
MC
D000818:Animals; D001938:Brazil; D003428:Cross Infection; D006460:Hemolysin Proteins / Q000378:metabolism*; D006461:Hemolysis; D006801:Humans; D006877:Hydroxamic Acids / Q000378:metabolism; D051379:Mice; D012706:Serratia marcescens / Q000378:metabolism* / Q000472:pathogenicity; D014774:Virulence
D006460:Hemolysin Proteins; D006877:Hydroxamic Acids; C031819:aerobactin