title: Locally invasive pulmonary aspergillosis in a healthy man successfully treated with oral fluconazole.
abstract: A 74-year-old healthy man with locally invasive form of pulmonary aspergillosis (PA) is reported. Chest X-ray film showed a segmental infiltration of right upper lobe (RUL) without cavitation, and the transbronchial lung biopsy specimen contained numerous hyphae of aspergillus species. Complication of bronchial asthma, or bronchiectasis were absent, and hyphae of aspergillus were present at only one segment of RUL. After 5 months of therapy with oral fluconazole, the PA had dramatically improved. Fluconazole was found to be effective for the locally invasive form of PA in a healthy man.
authors.affiliation: Division of Pulmonary Medicine, Ishikawa Prefectural Central Hospital, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Nishi
authors.forename: S
authors.initials: S
authors.lastname: Myou
authors.forename: T
authors.initials: T
authors.lastname: Ooka
authors.forename: M
authors.initials: M
authors.lastname: Fujimura
authors.forename: T
authors.initials: T
authors.lastname: Matsuda
mesh_terms: D000284:Administration, Oral; D000368:Aged; D001228:Aspergillosis / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000473:pathology; D015725:Fluconazole / Q000008:administration & dosage*; D006801:Humans; D008172:Lung Diseases, Fungal / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000473:pathology; D008297:Male; D014057:Tomography, X-Ray Computed
chemical_list: D015725:Fluconazole