title: [Effect of loratadine (LO), a selective H1 antagonist, on histamine-induced bronchoconstriction].
abstract: The influence of single and repeated LO (10 mg/day) doses on histamine-induced bronchoconstriction was studied in 11 patients with stabile bronchial asthma. Bronchial reactivity was estimated as histamine content potent to elicit a 20% FEV, fall, i.e. PC20H. A single dose gave a significant (5.5 fold) reduction in bronchial reactivity to inhaled histamine. Application of LO during 6 days gave a similar effect. Withdrawal of LO for 6 days yielded an increase in bronchial hyperreactivity.
authors.affiliation: Kliniki Pneumonologii i Alergologii IMW AM, Lodzi.
authors.forename: I
authors.initials: I
authors.lastname: Grzelewska-Rzymowska
authors.forename: K
authors.initials: K
authors.lastname: Gondorowicz
authors.forename: G
authors.initials: G
authors.lastname: Cieślewicz
authors.forename: J
authors.initials: J
authors.lastname: Rozniecki
authors.forename: B
authors.initials: B
authors.lastname: Wojciechowska
mesh_terms: D000328:Adult; D001249:Asthma / Q000175:diagnosis / Q000188:drug therapy*; D001985:Bronchial Provocation Tests; D016084:Bronchoconstriction / Q000187:drug effects*; D005260:Female; D006632:Histamine; D006801:Humans; D017336:Loratadine / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged
chemical_list: D017336:Loratadine; D006632:Histamine
vernacular_title: Wpływ loratadyny, wybiórczego antagonisty receptorów histaminowych (H1), na skurcz oskrzeli wywołany wziewaniem histaminy.