Shortening of N1 and P3 latencies in event-related potentials observed coincidentally with clinical improvement during nootropic medication in a demented patient: specific effect of nicergoline.
Event-related potentials, measured eight times in a patient in the early stages of dementia, demonstrated that clinical symptoms, especially loss of motivation, improved coincidentally with a shortening of reaction time, N1 latency, and P3 latency during nicergoline medication among three nootropics prescribed. Such a longitudinal study design was considered to be useful for quantifying and objectively comparing effects of various nootropics noninvasively.
Fukuda
M
M
Department of Neuropsychiatry, Faculty of Medicine, University of Tokyo, Japan.
Hiramatsu
K
K
Honda
M
M
Niwa
S
S
Sasaki
T
T
Hata
A
A
Nakagome
K
K
Iwanami
A
A
Honda
H
H
Hayashida
S
S
D000368:Aged; D001559:Benzhydryl Compounds / Q000627:therapeutic use; D003704:Dementia / Q000188:drug therapy* / Q000503:physiopathology*; D004569:Electroencephalography; D005071:Evoked Potentials / Q000502:physiology*; D006801:Humans; D008297:Male; D009025:Morpholines / Q000627:therapeutic use; D009530:Nicergoline / Q000627:therapeutic use*; D011619:Psychotropic Drugs / Q000627:therapeutic use; D011930:Reaction Time / Q000502:physiology
D001559:Benzhydryl Compounds; D009025:Morpholines; D011619:Psychotropic Drugs; C020852:indeloxazine; D009530:Nicergoline; C031906:bifemelane