Fraction of spleen cells responsible for suppression of cellular immune response to SRBC in mice treated with outer membrane proteins of Shigella.
Effect of splenocytes isolated from mice immunized with suppressive dose of OMP from Shigella on delayed hypersensitivity, induced in mice with sheep red blood cells was investigated. Only the population of T lymphocytes was found to suppress the delayed hypersensitivity, as measured by the footpad reaction. The results suggest that OMP of Shigella are able to induce in the spleens of animals active T cells which are responsible for the suppression of cellular response induced by SRBC.
Czarny
A
A
Department of Immunology of Infectious Diseases, Polish Academy of Sciences, Wrocław.
Witkowska
D
D
Mulczyk
M
M
D000818:Animals; D000942:Antigens, Bacterial / Q000276:immunology*; D000961:Antilymphocyte Serum / Q000494:pharmacology; D001425:Bacterial Outer Membrane Proteins / Q000276:immunology*; D004487:Edema / Q000276:immunology; D004912:Erythrocytes / Q000276:immunology*; D005528:Foot; D006968:Hypersensitivity, Delayed / Q000276:immunology; D007108:Immune Tolerance; D007111:Immunity, Cellular; D016219:Immunotherapy, Adoptive; D051379:Mice; D012756:Sheep; D012763:Shigella flexneri / Q000276:immunology*; D013154:Spleen / Q000166:cytology* / Q000276:immunology; D016176:T-Lymphocyte Subsets / Q000276:immunology; D050378:T-Lymphocytes, Regulatory / Q000276:immunology
D000942:Antigens, Bacterial; D000961:Antilymphocyte Serum; D001425:Bacterial Outer Membrane Proteins