title: Failure of adrenocorticotrophic hormone to release serum amyloid A in cattle.
abstract: The objective of this study was to determine whether adrenocorticotrophic hormone plays a direct role in the secretion of serum amyloid A (SAA) in cattle. Seven lactating Holstein-Friesian cows were given either saline or 25 iu adrenocorticotrophic hormone (ACTH) intravenously at 09.00 in a two factor crossover design. Plasma cortisol concentrations had increased significantly by one hour after the injection of ACTH, whereas the SAA level had not increased by 24 hours after injection. It is concluded that in cattle adrenocorticotrophic hormone has no direct influence on the release of SAA by the hepatocyte.
authors.affiliation: Faculty of Veterinary Medicine, State University of Utrecht, The Netherlands.
authors.forename: J H
authors.initials: JH
authors.lastname: van der Kolk
authors.forename: S P
authors.initials: SP
authors.lastname: Alsemgeest
authors.forename: T
authors.initials: T
authors.lastname: Wensing
authors.forename: T A
authors.initials: TA
authors.lastname: Niewold
authors.forename: E
authors.initials: E
authors.lastname: Gruys
authors.forename: J A
authors.initials: JA
authors.lastname: Mol
authors.forename: H J
authors.initials: HJ
authors.lastname: Breukink
mesh_terms: D000324:Adrenocorticotropic Hormone / Q000494:pharmacology / Q000502:physiology*; D000818:Animals; D002417:Cattle / Q000378:metabolism*; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006854:Hydrocortisone / Q000097:blood; D008099:Liver / Q000187:drug effects / Q000378:metabolism*; D011863:Radioimmunoassay; D000685:Serum Amyloid A Protein / Q000378:metabolism*
chemical_list: D000685:Serum Amyloid A Protein; D000324:Adrenocorticotropic Hormone; D006854:Hydrocortisone