Effect of vitamin E on the immunoreactivity of spleen cells in hyperlipidaemic rats.
Atherogenic (lipid-rich) diet suppressed mitogen-induced lymphocyte blastogenic responses in rats. Supplementation with vitamin E completely abolished the suppressive effect of the diet. The atherogenic diet also decreased the tumour necrosis factor alpha (TNF-alpha) activity produced by spleen macrophages, however, vitamin E supplementation failed to abolish this effect. Diet or supplementation had no measurable action on interleukin-1 (IL-1) production of macrophages.
González-Cabello
R
R
Second Department of Medicine, Semmelweis University Medical School, Budapest, Hungary.
Blázovics
A
A
Horváth
M E
ME
Müzes
G
G
Gergely
P
P
Fehér
J
J
D000818:Animals; D002478:Cells, Cultured; D003208:Concanavalin A; D004036:Diet, Atherogenic; D006949:Hyperlipidemias / Q000097:blood / Q000276:immunology*; D007375:Interleukin-1 / Q000096:biosynthesis; D008055:Lipids / Q000097:blood; D008070:Lipopolysaccharides / Q000494:pharmacology; D008213:Lymphocyte Activation / Q000187:drug effects*; D008214:Lymphocytes / Q000187:drug effects / Q000276:immunology*; D008297:Male; D009000:Monocytes / Q000187:drug effects / Q000276:immunology; D051381:Rats; D017208:Rats, Wistar; D013154:Spleen / Q000276:immunology; D014409:Tumor Necrosis Factor-alpha / Q000096:biosynthesis; D014810:Vitamin E / Q000494:pharmacology*
D007375:Interleukin-1; D008055:Lipids; D008070:Lipopolysaccharides; D014409:Tumor Necrosis Factor-alpha; D003208:Concanavalin A; D014810:Vitamin E