[Hemodynamic study of intravenous milrinone in 26 patients with NYHA class III or IV cardiac failure].
The hemodynamic effects of milrinone (WIN 47203) were studied in 26 NYHA Class III or IV patients. The compound was administered intravenously using a protocol including an initial push dose of 50 micrograms/kg in 10 min, followed by a 24 hour infusion at the dose of 0.5 microgram/kg/min. Maximal response was obtained after 15 min and persisted during the infusion: cardiac index increased from 2.08 +/- 0.36 l/min/m2 to 3.09 +/- 0.68 l/min/m2, while capillary pressure fell from 25 mmHg to 16-17 mmHg. These variations were significant (p = 0.01). Heart rate was stable. Mean peripheral blood pressure fell modestly (6%). Systemic vascular resistance fell by 30% and pulmonary vascular resistance by 20%. All these results confirmed the beneficial effect of this inotropic agent administered intravenously. The increase in ventricular premature contractions noted by many justifies the careful surveillance of these patients by monitoring.
Boesch
C
C
Service de Médecine IV, Hôpital Henri Mondor, Créteil.
Dubois-Rande
J L
JL
Pochmalicki
G
G
Lellouche
D
D
Teiger
E
E
Saal
J P
JP
Cachin
J C
JC
Mallo
C
C
Castaigne
A
A
Jan
F
F
D000328:Adult; D000368:Aged; D002316:Cardiotonic Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D004341:Drug Evaluation; D005260:Female; D006333:Heart Failure / Q000188:drug therapy*; D006439:Hemodynamics / Q000187:drug effects*; D006801:Humans; D007275:Injections, Intravenous; D008297:Male; D008875:Middle Aged; D020105:Milrinone; D011728:Pyridones / Q000008:administration & dosage / Q000627:therapeutic use*
D002316:Cardiotonic Agents; D011728:Pyridones; D020105:Milrinone
Etude hémodynamique de la milrinone par voie intraveineuse chez 26 patients en insuffisance cardiaque de classe III ou IV de la NYHA.