A new metabolite of 2,4,3',4'-tetrachlorobiphenyl in rat feces.
Metabolism in vivo of 2,4,3',4'-tetrachlorobiphenyl (TCB) was further studied using male Wistar rats. When the extract of feces of rats given TCB with chloroform was methylated and applied to gas chromatography (GC)-mass spectrometry (MS), a new metabolite was detected. The structure of this new metabolite was 4-hydroxy-2,5,3'4'-TCB based on both its retention time in GC and comparison of the mass spectrum with that of the synthetic sample. 4-Hydroxy-2,5,3',4'-TCB was assumed to be formed via a 4,5-oxide intermediate followed by NIH-shift of a chlorine atom at 4-position.
Koga
N
N
Department of Food and Nutrition, Nakamura Gakuen College, Fukuoka, Japan.
Shin'yama
A
A
Ishida
C
C
Hanioka
N
N
Yoshimura
H
H
D000818:Animals; D001711:Biotransformation; D005243:Feces / Q000737:chemistry*; D008297:Male; D008745:Methylation; D011078:Polychlorinated Biphenyls / Q000737:chemistry / Q000378:metabolism*; D051381:Rats; D017208:Rats, Wistar
D011078:Polychlorinated Biphenyls; C078132:2,3,5,6-tetrachlorobiphenyl