title: [Therapeutic effects of cefprozil in the treatment of various infectious diseases in children].
abstract: Therapeutic effects of cefprozil (CFPZ, BMY-28100), a new cephalosporin, were examined in various infectious diseases in children. Clinical efficacy rates were 50% (2/4) in acute bronchitis, 80% (4/5) in pharyngitis, 0% in laryngitis, 100% (7/7) in tonsillitis, 100% (8/8) in impetigo contagiosa, furuncle and posthitis. Hence, the overall efficacy rate was 84% (21/25). Adverse effects were observed in 1 case with slightly elevated serum GOT and GPT. Changes in serum concentrations and urinary excretion of CFPZ were examined in 4 and 2 children without infection, respectively. T 1/2 values obtained were between 1 hour to 2 hours (bioassay). Six hour recovery rates in urine were 51.8% and 77.8% (bioassay). CFPZ was considered to be a safe and useful drug in treating various infectious diseases in children.
authors.affiliation: Department of Pediatrics, Kochi Medical School.
authors.forename: H
authors.initials: H
authors.lastname: Wakiguchi
authors.forename: N
authors.initials: N
authors.lastname: Ohishi
authors.forename: S
authors.initials: S
authors.lastname: Kido
authors.forename: T
authors.initials: T
authors.lastname: Takechi
authors.forename: K
authors.initials: K
authors.lastname: Takeda
authors.forename: K
authors.initials: K
authors.lastname: Yoshimura
authors.forename: I
authors.initials: I
authors.lastname: Nomura
authors.forename: M
authors.initials: M
authors.lastname: Fujieda
authors.forename: K
authors.initials: K
authors.lastname: Araki
authors.forename: T
authors.initials: T
authors.lastname: Kurashige
mesh_terms: D000284:Administration, Oral; D000293:Adolescent; D000367:Age Factors; D001419:Bacteria / Q000187:drug effects / Q000302:isolation & purification; D001424:Bacterial Infections / Q000188:drug therapy* / Q000382:microbiology; D002511:Cephalosporins / Q000493:pharmacokinetics / Q000494:pharmacology / Q000627:therapeutic use*; D002648:Child; D002675:Child, Preschool; D004341:Drug Evaluation; D004352:Drug Resistance, Microbial; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D000097670:Cefprozil
chemical_list: D002511:Cephalosporins; D000097670:Cefprozil