Effects of HS-142-1, a novel non-peptide ANP antagonist, on diuresis and natriuresis induced by acute volume expansion in anesthetized rats.
In this study we used HS-142-1, a novel non-peptide antagonist for the atrial natriuretic peptide (ANP) receptor, to clarify the possible physiological significance of ANP in acute hypervolemia. Substantial volume expansion in anesthetized rats induced a strong diuresis and natriuresis. These renal responses were significantly blocked by HS-142-1 at a dose of 3.0 mgkg-1 i.v. This observation suggests that ANP and its guanylyl cyclase-coupled receptor are, under the present conditions, physiologically involved that appears to be responsible for the renal responses in the volume homeostasis.
Sano
T
T
Tokyo Research Laboratories, Kyowa Hakko Kogyo Co., Ltd., Tokyo, Japan.
Morishita
Y
Y
Yamada
K
K
Matsuda
Y
Y
D000818:Animals; D009320:Atrial Natriuretic Factor / Q000037:antagonists & inhibitors*; D006152:Cyclic GMP / Q000652:urine; D004231:Diuresis / Q000187:drug effects*; D008297:Male; D009318:Natriuresis / Q000187:drug effects*; D011134:Polysaccharides / Q000494:pharmacology*; D011188:Potassium / Q000652:urine; D051381:Rats; D011919:Rats, Inbred Strains; D012016:Reference Values; D012965:Sodium Chloride / Q000494:pharmacology*; D013997:Time Factors
C072551:HS 142-1; D011134:Polysaccharides; D012965:Sodium Chloride; D009320:Atrial Natriuretic Factor; D006152:Cyclic GMP; D011188:Potassium