title: Erythro-toxicity of dichlorvos and possibility of its modification in vitro.
abstract: The purpose of this study was to investigate the in vitro effects of dichlorvos (organophosphorous pesticide) on the biological value of erythrocytes; an in vitro test of erythrocyte protection against DDVP effects was also included. A significant decrease of glutathione level with concomitant increase of methemoglobin and denatured hemoglobin levels, as well as a rise of Heinz body number were observed after 24 h following the treatment with dichlorvos (100 microM). Preincubation of erythrocytes with glutathione prevented the toxic effects of the pesticide with the maintenance of both glutathione and methemoglobin at a control level.
authors.affiliation: Department of Physiopathology, Institute of Hematology and Blood Transfusion, Warsaw.
authors.forename: J
authors.initials: J
authors.lastname: Woźniak
authors.forename: M
authors.initials: M
authors.lastname: Grabarczyk
mesh_terms: D002478:Cells, Cultured; D004006:Dichlorvos / Q000633:toxicity*; D004912:Erythrocytes / Q000737:chemistry / Q000187:drug effects*; D005978:Glutathione / Q000494:pharmacology*; D006454:Hemoglobins / Q000032:analysis; D006801:Humans; D008706:Methemoglobin / Q000032:analysis
chemical_list: D006454:Hemoglobins; D004006:Dichlorvos; D008706:Methemoglobin; D005978:Glutathione