Blood levels and urinary excretion of thiamin and riboflavin during oral administration of multivitamin tablets to healthy adults.
1. The baseline blood thiamin concentration increased gradually during the long-term administration of TTFD, and the blood concentration was dose-dependent. The cumulative urinary thiamin excretion showed the same dose-dependence as the blood concentration. 2. The baseline blood riboflavin concentration also increased steadily during the administration period, but the increase was less than that of thiamin. Dose-dependence of the cumulative urinary excretion of riboflavin was noted. 3. No side effect were observed.
Itokawa
Y
Y
Department of Hygiene, Faculty of Medicine, Kyoto University, Japan.
Kimura
M
M
Nishino
K
K
Mino
M
M
Kitagawa
M
M
Matsuoka
M
M
Otsuka
H
H
D000284:Administration, Oral; D000328:Adult; D004334:Drug Administration Schedule; D006801:Humans; D008297:Male; D012016:Reference Values; D012256:Riboflavin / Q000097:blood / Q000378:metabolism* / Q000652:urine; D013607:Tablets; D013831:Thiamine / Q000097:blood / Q000378:metabolism* / Q000652:urine; D014815:Vitamins / Q000008:administration & dosage / Q000493:pharmacokinetics*
D013607:Tablets; D014815:Vitamins; D012256:Riboflavin; D013831:Thiamine