[Association studies in cancerology: the example of gene L-myc polymorphism associated with the incidence of pulmonary metastases in breast cancers].
Genes, which are implicated in the pathogenesis of human tumors, may demonstrate Restriction Fragment Length Polymorphism (RFLP). Population studies of such RFLP are of potential interest for a genetic analysis of cancer susceptibility. The initial data of Krontiris et al has shown a significant increase of rare c-Ha-ras-1 alleles in individuals with tumors. Since then, other significant associations have been found between other genes RFLPs and various tumors. In this paper, we report that L-myc RFLP may prove useful in identifying breast cancer patients at high risk of developing lung metastases.
Champème
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MH
Laboratoire d'oncovirologie, centre René-Huguenin, Saint-Cloud, France.
Bièche
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Latil
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Hacène
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Lidereau
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D000328:Adult; D001943:Breast Neoplasms / Q000235:genetics*; D004198:Disease Susceptibility; D005260:Female; D016259:Genes, myc; D006801:Humans; D008175:Lung Neoplasms / Q000235:genetics / Q000556:secondary*; D008875:Middle Aged; D011110:Polymorphism, Genetic; D012189:Retrospective Studies
Etudes d'association en cancérologie: l'exemple du polymorphisme du gène L-myc associé à l'incidence de métastases pulmonaires dans le cancer du sein.