Effects of a new antiarrhythmic drug, SD-3212, on canine ventricular arrhythmia models.
The antiarrhythmic effects of a new antiarrhythmic agent, SD-3212, (-)-(S)-3,4-Dihydro-2-[5-methoxy-2-[3-[N-methyl-N-[2-[(3,4- methylene dioxy)phenoxy]ethyl]amino]propoxy]phenyl]-4-methyl-3-oxo-2H-1, 4-benzothiazine hydrogen fumarate, were investigated using canine models of ventricular arrhythmias, i.e. spontaneously occurring digitalis-, two-stage coronary ligation- and adrenaline-induced arrhythmias. SD-3212 suppressed adrenaline-induced arrhythmia and showed some antiarrhythmic effect on digitalis- and 48 hr coronary ligation-arrhythmias. These results indicate that SD-3212 has antiarrhythmic effects common among class IV antiarrhythmic drugs and also has additional efficacy common among class I antiarrhythmic drugs, thus when considering the level of experimental arrhythmias it somewhat resembles propafenone. It may therefore become a clinically useful antiarrhythmic drug among typical class I or class IV antiarrhythmic drugs.
Hirasawa
A
A
Department of Pharmacology, Yamanashi Medical College, Japan.
Haruno
A
A
Matsuzaki
T
T
Hashimoto
K
K
D000818:Animals; D000889:Anti-Arrhythmia Agents / Q000494:pharmacology*; D001145:Arrhythmias, Cardiac / Q000139:chemically induced / Q000209:etiology / Q000503:physiopathology*; D003331:Coronary Vessels; D004070:Digitalis; D004285:Dogs; D004837:Epinephrine; D005260:Female; D008026:Ligation; D008297:Male; D009994:Osmolar Concentration; D010946:Plants, Medicinal; D010947:Plants, Toxic; D013844:Thiazoles / Q000097:blood / Q000494:pharmacology*
D000889:Anti-Arrhythmia Agents; D013844:Thiazoles; C064356:sesamodil; D004837:Epinephrine