title: Human parvovirus B19 infection in hemophiliacs first infused with two high-purity, virally attenuated factor VIII concentrates.
abstract: Human parvovirus B19 can be transmitted by coagulation factor concentrates and is highly resistant to virucidal methods. To evaluate whether the additional removal of virus by chromatographic methods during the manufacture of high-purity concentrates reduces the risk of B19 transmission, we have prospectively evaluated the rate of anti-B19 seroconversion in two groups of susceptible (anti-B19 negative) hemophiliacs infused with high-purity, heated (pasteurized) or solvent-detergent-treated factor VIII concentrates. Both products infected a relatively high proportion of patients (nine of 20).
authors.affiliation: Institute of Microbiology, University of Florence, Italy.
authors.forename: A
authors.initials: A
authors.lastname: Azzi
authors.forename: S
authors.initials: S
authors.lastname: Ciappi
authors.forename: K
authors.initials: K
authors.lastname: Zakvrzewska
authors.forename: M
authors.initials: M
authors.lastname: Morfini
authors.forename: G
authors.initials: G
authors.lastname: Mariani
authors.forename: P M
authors.initials: PM
authors.lastname: Mannucci
mesh_terms: D003902:Detergents; D005169:Factor VIII / Q000627:therapeutic use*; D006467:Hemophilia A / Q000628:therapy*; D006801:Humans; D007074:Immunoglobulin G / Q000032:analysis; D010321:Parvoviridae / Q000276:immunology; D010322:Parvoviridae Infections / Q000209:etiology*; D012997:Solvents
chemical_list: D003902:Detergents; D007074:Immunoglobulin G; D012997:Solvents; D005169:Factor VIII