[Effect of panaxatriol saponins isolated from Panax notoginseng (PTS) on myocardial ischemic arrhythmia in mice and rats].
PTS, one of the major effective components of Panax notoginseng was found to exert remarked antiarrhythmic activities on coronary artery ligation induced ischemic and reperfused arrhythmias in rats. PTS also reduced the size of myocardial infarct. For i.v. CaCl2-Ach induced atrial fibrillation and/or flutter in mice, PTS produced a significant protective effect. In addition, PTS showed an action of prolonging the life under the condition of normobaric hypoxia.
Gao
B Y
BY
Deparment of Pharmacology, Beijing Medical University.
Li
X J
XJ
Liu
L
L
Zhang
B H
BH
D000818:Animals; D000889:Anti-Arrhythmia Agents / Q000627:therapeutic use*; D001145:Arrhythmias, Cardiac / Q000188:drug therapy* / Q000209:etiology; D001281:Atrial Fibrillation / Q000517:prevention & control; D001282:Atrial Flutter / Q000517:prevention & control; D005260:Female; D036145:Ginsenosides; D008297:Male; D051379:Mice; D017202:Myocardial Ischemia / Q000150:complications; D015428:Myocardial Reperfusion Injury / Q000150:complications; D051381:Rats; D017208:Rats, Wistar; D012503:Saponins / Q000627:therapeutic use; D014315:Triterpenes / Q000627:therapeutic use*
D000889:Anti-Arrhythmia Agents; D036145:Ginsenosides; D012503:Saponins; D014315:Triterpenes; C004563:panaxatriol