[The adrenergic regulation of cardiomyocyte electrophysiological activity, cardiac biochemical function and coronary blood flow in rats with incorporated 131I].
The study was made of the rat heart isolated according to Langendorf and right auricles. Intraperitoneal injections of 2.5 MBq/kg 131I were performed. Electrophysiological and biomechanical myocardium response to stimulation of alpha and beta-adrenoreceptors with isoprenalin and phenylephrine hydrochloride was analyzed. Postradiation modification of adrenergic control in animals with incorporated 131I appeared as reduced functional response of cardiomyocytes and intact heart to beta-adrenoagonist and enhanced response to alpha-agonist was detected.
Kirienko
A E
AE
Petrashevskaia
N N
NN
Lobanok
L M
LM
D000818:Animals; D003326:Coronary Circulation / Q000187:drug effects / Q000502:physiology / Q000528:radiation effects*; D004594:Electrophysiology; D005260:Female; D006321:Heart / Q000187:drug effects / Q000502:physiology / Q000528:radiation effects*; D007457:Iodine Radioisotopes / Q000494:pharmacology*; D007545:Isoproterenol / Q000494:pharmacology; D009206:Myocardium / Q000378:metabolism*; D010656:Phenylephrine / Q000494:pharmacology; D051381:Rats; D017208:Rats, Wistar; D011941:Receptors, Adrenergic / Q000187:drug effects / Q000502:physiology / Q000528:radiation effects*; D013997:Time Factors
D007457:Iodine Radioisotopes; D011941:Receptors, Adrenergic; D010656:Phenylephrine; D007545:Isoproterenol
Adrenergicheskaia reguliatsiia élektrofiziologicheskoĭ aktivnosti kardiomiotsitov, biokhimicheskoĭ funktsii serdtsa i koronarnogo krovotoka u krys s inkorporirovannym 131I.