title: [Colon adenocarcinoma with neuroendocrine and squamous cell differentiation. A case report].
abstract: A tubular adenocarcinoma of the colon with solid area composed by small cells that was found by immunohistochemistry study using antibody to neuron-specific enolase (NSE) to possess neuroendocrine differentiation is related. In another areas of the tumor were visualized keratinizing squamous cells. The presence of neuro-endocrine and squamous cells features provide further evidence that neoplastic colonic cells have the capacity for multi-directional differentiation. The implications of this combination in relation to theories of tumor origin and differentiation and the prognostic significance of neuro-endocrine cells in malignant neoplasms of the gastrointestinal tract are discussed.
authors.affiliation: Departamento de Patologia da Faculdade de Medicina de Botucatu da Universidade Estadual Paulista-UNESP, SP.
authors.forename: G C
authors.initials: GC
authors.lastname: Santos
authors.forename: S
authors.initials: S
authors.lastname: Zucoloto
authors.forename: K I
authors.initials: KI
authors.lastname: Coelho
authors.forename: F C
authors.initials: FC
authors.lastname: Schmitt
mesh_terms: D000230:Adenocarcinoma / Q000473:pathology*; D000368:Aged; D002294:Carcinoma, Squamous Cell / Q000473:pathology*; D002454:Cell Differentiation; D003110:Colonic Neoplasms / Q000473:pathology*; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D009490:Neurosecretory Systems / Q000473:pathology*
vernacular_title: Adenocarcinoma de cólon com diferenciação neuro-endócrina e escamosa. Relato de caso.