title: [Contribution of chemiluminescence for determination of low value TSH in patients with dysthyroidism during negative TRH test].
abstract: TSH values performed by immunoradiometric method were compared with chemiluminescent method in 28 hyperthyroid patients with negative TRH-test. This last method gives a better sensitivity (0.020 mUI/L vs. 0.050 mUI/L) and reproducibility (5% V.C. vs. 40%). The measure of undetectable TSH by immunoradiometric assay becomes possible with chemiluminescence. Due to this increase of sensitivity, the TRH-test needs to be reconsidered and allows to discriminate various degrees of TSH suppression.
authors.affiliation: Laboratoire de Médecine Nucléaire, CHRU de Saint Etienne, Hôpital Bellevue, Saint Etienne.
authors.forename: A
authors.initials: A
authors.lastname: Caillot
authors.forename: M
authors.initials: M
authors.lastname: Vindimian
authors.forename: B
authors.initials: B
authors.lastname: Estour
authors.forename: C
authors.initials: C
authors.lastname: Soler
authors.forename: S
authors.initials: S
authors.lastname: Delabre
authors.forename: L
authors.initials: L
authors.lastname: Blanc
authors.forename: J
authors.initials: J
authors.lastname: Peng
authors.forename: H
authors.initials: H
authors.lastname: Rousset
authors.forename: J C
authors.initials: JC
authors.lastname: Healy
mesh_terms: D000328:Adult; D000368:Aged; D005260:Female; D006801:Humans; D015592:Immunoradiometric Assay; D008163:Luminescent Measurements; D008297:Male; D008875:Middle Aged; D015203:Reproducibility of Results; D013959:Thyroid Diseases / Q000097:blood*; D013972:Thyrotropin / Q000097:blood*; D013973:Thyrotropin-Releasing Hormone
chemical_list: D013973:Thyrotropin-Releasing Hormone; D013972:Thyrotropin
vernacular_title: Apport de la chimiluminescence au dosage de valeurs basses de TSH chez des patients souffrant de dysthyroïdie lors de test à la TRH non répondant.