[Multiparameter analysis of pharmacological specificity of 3-benzylchromone (homoisoflavone) derivatives on different pharmacological tests in vitro].
For access to structure/activity/specificity of a serie of eight 3-benzylchromones (homoisoflavones), the authors used multivariate analysis. The obtained results allow to envisage the synthesis of molecules more specific of one of the three types of activities studied: angioprotective, antihistaminic, antiallergic.
Doré
J C
JC
URA 401 du CNRS, Muséum National d'Histoire Naturelle, Paris.
Kirkiacharian
S
S
Viel
C
C
D001593:Benzyl Compounds / Q000737:chemistry / Q000494:pharmacology*; D002867:Chromones / Q000737:chemistry / Q000494:pharmacology*; D066298:In Vitro Techniques; D015999:Multivariate Analysis; D012680:Sensitivity and Specificity; D013329:Structure-Activity Relationship; D013678:Technology, Pharmaceutical / Q000706:statistics & numerical data
D001593:Benzyl Compounds; D002867:Chromones
Analyse multiparamétrique de la spécificité pharmacologique de dérivés de la 3-benzylchromone (homoisoflavone) sur différents tests pharmacologiques in vitro.