title: Cytotoxic activity of tetraprenylphenols related to suillin, an antitumor principle from Suillus granulatus.
abstract: Cytotoxic activity against three tumor cell lines (KB, P-388, and NSCLC-N6) has been determined for 14 natural and semisynthetic tetraprenylphenols. Structure-activity relationships have been examined.
authors.affiliation: Istituto del CNR per lo Studio delle Sostanze Naturali, Valverde CT, Italy.
authors.forename: C
authors.initials: C
authors.lastname: Geraci
authors.forename: M
authors.initials: M
authors.lastname: Piattelli
authors.forename: C
authors.initials: C
authors.lastname: Tringali
authors.forename: J F
authors.initials: JF
authors.lastname: Verbist
authors.forename: C
authors.initials: C
authors.lastname: Roussakis
mesh_terms: D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000494:pharmacology*; D001487:Basidiomycota / Q000737:chemistry*; D002470:Cell Survival / Q000187:drug effects; D004224:Diterpenes / Q000494:pharmacology*; D006801:Humans; D007624:KB Cells / Q000187:drug effects; D007941:Leukemia P388 / Q000473:pathology; D010636:Phenols / Q000494:pharmacology*; D013329:Structure-Activity Relationship; D014407:Tumor Cells, Cultured / Q000187:drug effects
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D004224:Diterpenes; D010636:Phenols; C061636:suillin