title: [Strong and weak histocompatibility antigens and immune response].
abstract: In blood samples of 88 healthy donors various red cell, HLA-A, -B, -Cw and -Dr antigens were determined by standard methods. Lymphocyte reactivity was measured by 3H-thymidine uptake into DNA of lymphoblastic cells stimulated by 14 different mitogens and antigens. Cluster analysis confirmed by t test and F test defined 3 distinct clusters of lymphocyte reactivity. Cluster 1 in 70% [relative risk (r.r.) 109, p < 0.001] and cluster 3 in 92% (r.r. 33, p < 0.01) showed significantly different cumulations of 3 or more increased characteristic red cell and HLA antigens. Our data suggest that the patterns of both red cell and HLA antigens play a major role in defining immunoreactivity.
authors.affiliation: Abteilung Innere Medizin, Universitätsklinikum Rudolf Virchow, Freie Universität Berlin, BRD.
authors.forename: G
authors.initials: G
authors.lastname: Wittmann
authors.forename: W
authors.initials: W
authors.lastname: Mempel
authors.forename: M U
authors.initials: MU
authors.lastname: Heim
authors.forename: R
authors.initials: R
authors.lastname: Eckstein
mesh_terms: D006680:HLA Antigens / Q000276:immunology*; D006801:Humans; D007519:Isoantigens / Q000276:immunology; D008213:Lymphocyte Activation / Q000276:immunology*; D012016:Reference Values
chemical_list: D006680:HLA Antigens; D007519:Isoantigens
vernacular_title: Starke und schwache Histokompatibilitätsantigene und Immunantwort.