title: Acute toxicities of 2-dialkylaminoalkyl-(dialkylamido)-fluoro-phosphates.
abstract: Toxicities expressed as LD50 values of 2-dialkylaminoalkyl-(dialkylamido)-fluorophosphates for rats and mice (i.m. administration) were determined. Rats were more sensitive to these compounds than mice: LD50 values varied from 17 (rats) to 1222 (mice) micrograms/kg. LD50 values at different routes of administration (i.v., i.m., s.c., p.o. and p.c.) for one derivative of this group, 2-dimethylaminoethyl-(dimethylamido)-fluorophosphate, were determined. Depending on the route of administration, LD50 values varied from 11 (i.v.) to 190 (p.o.) micrograms/kg for rats and from 27.6 (i.v.) to 222 (p.o.) micrograms/kg for mice, respectively. Percutaneous toxicity in rats only (LD50 = 1366 micrograms/kg) was determined.
authors.affiliation: Purkynĕ Military Medical Academy, Hradec Králové, Czechoslovakia.
authors.forename: J
authors.initials: J
authors.lastname: Bajgar
authors.forename: J
authors.initials: J
authors.lastname: Fusek
authors.forename: V
authors.initials: V
authors.lastname: Hrdina
authors.forename: J
authors.initials: J
authors.lastname: Patocka
authors.forename: J
authors.initials: J
authors.lastname: Vachek
mesh_terms: D000818:Animals; D004333:Drug Administration Routes; D005260:Female; D006845:Hydrocarbons, Fluorinated / Q000633:toxicity*; D007928:Lethal Dose 50; D051379:Mice; D010710:Phosphates / Q000633:toxicity; D051381:Rats
chemical_list: D006845:Hydrocarbons, Fluorinated; D010710:Phosphates