Possible role of bile deficiency in the development of intestinal syndrome of acute radiation disease.
Experimentally induced bile deficiency significantly accelerates the development of acute gastrointestinal syndrome in the irradiated rat. The usual 11 days of survival is reduced to 5 days. In view of the experimental results it seems justifiable to conclude that endotoxins play an important role in the development of this syndrome.
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Frédéric Joliot-Curie National Research, Institute for Radiobiology and Radiohygiene, Budapest, Hungary.
Sztanyik
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Bertók
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D000208:Acute Disease; D000818:Animals; D001646:Bile / Q000502:physiology; D001647:Bile Acids and Salts / Q000172:deficiency*; D004064:Digestive System / Q000528:radiation effects*; D005260:Female; D005767:Gastrointestinal Diseases / Q000209:etiology* / Q000503:physiopathology; D011833:Radiation Injuries, Experimental / Q000209:etiology* / Q000503:physiopathology; D051381:Rats; D017208:Rats, Wistar; D013577:Syndrome
D001647:Bile Acids and Salts