The automation of dissolution testing of solid oral dosage forms.
Dissolution testing of solid oral dosage forms plays a very important part both in the development of new products and in quality control. A fully automated system for dissolution testing known as AUTO DISS is presented and its components are described. On-line determination of active ingredient concentration is possible with the aid of an integrated automatic sampler in combination with various measuring instruments (UV-vis spectrometry, liquid chromatography and flow injection analysis). The suitability of the system is demonstrated by determination of the dissolution of brotizolam from tablets by FIA and of bepafant from capsules by diode-array spectroscopy.
Lamparter
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Department of Pharmaceutical Research and Development, Boehringer Ingelheim KG, Rhein, Germany.
Lunkenheimer
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CH
D001381:Azepines / Q000737:chemistry; D002214:Capsules / Q000032:analysis; D002626:Chemistry, Pharmaceutical / Q000295:instrumentation / Q000379:methods*; D002851:Chromatography, High Pressure Liquid; D017022:Flow Injection Analysis; D006993:Hypnotics and Sedatives / Q000737:chemistry; D010972:Platelet Activating Factor / Q000037:antagonists & inhibitors; D011786:Quality Control; D012995:Solubility; D013056:Spectrophotometry, Ultraviolet; D013057:Spectrum Analysis; D013607:Tablets / Q000032:analysis; D014230:Triazoles / Q000737:chemistry
D001381:Azepines; D002214:Capsules; D006993:Hypnotics and Sedatives; D010972:Platelet Activating Factor; D013607:Tablets; D014230:Triazoles; C020960:brotizolam; C063964:bepafant