[13C] breath test of medium-chain triglycerides and oligosaccharides in neonates.
It is suitable to examine the utilization of carbohydrates and fats using stable isotope-labelled substrates in neonates because of their non-radioactivity. Administering medium-chain triglycerides (MCT) and oligosaccharides is of use in enteral nutrition for a patient with a limited water intake such as a neonate. In this study, the oxidation of MCT and maltose administered orally as an energy supplement in neonates has been examined using a stable isotope-labelled breath test. Five normal term neonates and five growing preterm infants were given [13C]-trioctanoin orally and three growing preterm infants were given [13C]-glucose and [13C]-maltose orally. The [13C] enrichment in carbon dioxide was analyzed by isotope ratio mass spectrometry, and oxidation rates over 6 hr and 12 hr respectively, were calculated. The oxidation rates for [13C]-octanoin after 6 hr were 46.2 +/- 3.6% in preterm infants and 53.5 +/- 13.8% in normal neonates, respectively (no significant difference), and 58.4 +/- 9.4% and 52.8 +/- 6.0% for [13C]-glucose and [13C]-maltose, respectively (not significant). The results demonstrate that orally administered MCT and maltose are oxidized sufficiently in preterm infants.
Hoshi
J
J
Maternal and Perinatal Center, Tokyo Women's Medical College, Japan.
Nishida
H
H
Yasui
M
M
Ohishi
M
M
Takahashi
M
M
D001944:Breath Tests / Q000379:methods*; D002210:Caprylates / Q000378:metabolism*; D002247:Carbon Isotopes; D005947:Glucose / Q000378:metabolism; D006801:Humans; D007223:Infant; D007231:Infant, Newborn / Q000378:metabolism*; D007234:Infant, Premature / Q000378:metabolism*; D008320:Maltose / Q000378:metabolism*; D014280:Triglycerides / Q000378:metabolism*
D002210:Caprylates; D002247:Carbon Isotopes; D014280:Triglycerides; D008320:Maltose; C003637:tricaprylin; D005947:Glucose