title: Studies of the interaction between boron and calcium, and its modification by magnesium and potassium, in rats. Effects on growth, blood variables, and bone mineral composition.
abstract: Two experiments were performed to confirm that boron interacts with calcium, and that this interaction can be modified by dietary magnesium and potassium in the rat. Upon manipulating the dietary variables listed above, it was found that under certain conditions, boron and calcium deprivation similarly affected several variables; for example, they both could be made to elevate plasma alkaline phosphatase activity and to depress femur calcium concentration. Under some dietary conditions, both boron and calcium deprivation affected some variables related to blood or iron metabolism. However, the effects of dietary boron and calcium on spleen weight/body weight ratio, hematocrit, and femur iron concentration generally were not similar. Femur copper, magnesium, phosphorus, and zinc also were affected by an interaction between boron and calcium under some dietary conditions. The findings show that there is a relationship between boron and calcium, but they do not clearly indicate the nature of the relationship. However, the data suggest that boron and calcium act on similar systems in the rat.
authors.affiliation: United States Department of Agriculture, Grand Forks Human Nutrition Research Center, ND 58202-7166.
authors.forename: F H
authors.initials: FH
authors.lastname: Nielsen
authors.forename: T R
authors.initials: TR
authors.lastname: Shuler
mesh_terms: D000469:Alkaline Phosphatase / Q000097:blood*; D000818:Animals; D001835:Body Weight / Q000187:drug effects; D015519:Bone Density / Q000187:drug effects*; D001895:Boron / Q000172:deficiency / Q000494:pharmacology*; D001921:Brain / Q000187:drug effects; D002118:Calcium / Q000172:deficiency; D002136:Calcium, Dietary / Q000494:pharmacology*; D006128:Growth / Q000187:drug effects*; D008274:Magnesium / Q000494:pharmacology; D008275:Magnesium Deficiency / Q000503:physiopathology; D008297:Male; D009929:Organ Size / Q000187:drug effects; D017419:Potassium, Dietary / Q000494:pharmacology; D051381:Rats; D017207:Rats, Sprague-Dawley; D013154:Spleen / Q000187:drug effects
chemical_list: D002136:Calcium, Dietary; D017419:Potassium, Dietary; D000469:Alkaline Phosphatase; D008274:Magnesium; D001895:Boron; D002118:Calcium