title: Glaucoma filtering surgery with postoperative 5-fluorouracil in patients with intraocular inflammatory disease.
abstract: Twenty-one eyes of 18 patients with uncontrolled glaucoma and intraocular inflammatory disease had glaucoma filtering surgery with postoperative subconjunctival 5-fluorouracil (5-FU). Follow-up for eyes in which intraocular pressure was controlled ranged from 6 to 53 months (mean, 34 months; median, 35 months). Fifteen of 21 eyes (71%) had controlled intraocular pressure (21 mmHg or less). Control was achieved in 9 of 10 (90%) phakic eyes and in 6 of 11 (55%) aphakic or pseudophakic eyes with or without glaucoma medication. Four of six filter failures had a second filtering procedure with 5-FU, and of these four procedures, three were successful. Cataract progression occurred in 9 of 10 phakic eyes, leading to cataract surgery in 7 eyes. Other complications included corneal epithelial defects in 13 eyes, bleb leaks in 3 eyes, choroidal effusions in 13 eyes, 1 choroidal hemorrhage, 1 serous retinal detachment and macular retinal pigment epithelial disturbance associated with hypotony and choroidal effusion. Filtering surgery with postoperative subconjunctival 5-FU can successfully control intraocular pressure in eyes with ocular inflammatory disease.
authors.affiliation: Department of Ophthalmology, Cleveland Clinic Foundation, OH 44195-5024.
authors.forename: C J
authors.initials: CJ
authors.lastname: Patitsas
authors.forename: E J
authors.initials: EJ
authors.lastname: Rockwood
authors.forename: D M
authors.initials: DM
authors.lastname: Meisler
authors.forename: C Y
authors.initials: CY
authors.lastname: Lowder
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D002387:Cataract Extraction; D003228:Conjunctiva / Q000187:drug effects; D005260:Female; D005472:Fluorouracil / Q000627:therapeutic use*; D005500:Follow-Up Studies; D005901:Glaucoma / Q000601:surgery*; D006801:Humans; D007267:Injections; D007429:Intraocular Pressure; D008297:Male; D008875:Middle Aged; D011183:Postoperative Complications / Q000517:prevention & control; D012189:Retrospective Studies; D014130:Trabeculectomy; D014605:Uveitis / Q000601:surgery*; D014792:Visual Acuity
chemical_list: D005472:Fluorouracil