title: Rare earth metal ions for unprecedentedly fast RNA hydrolysis.
abstract: Adenylyl(3'-5')adenosine (ApA) and uridyl(3'-5')uridine (UpU) are hydrolyzed at unprecedentedly large rates by rare earth metal ions at pH 8, 30 degrees C. With 0.01 M Tm(III), the half-lives are 10 min and 51 min, respectively. Potentiality of these ions as catalytic center of artificial ribonuclease is proposed.
authors.affiliation: Department of Industrial Chemistry, Faculty of Engineering, University of Tokyo, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Matsumura
authors.forename: Y
authors.initials: Y
authors.lastname: Matsumoto
authors.forename: M
authors.initials: M
authors.lastname: Komiyama
mesh_terms: D002384:Catalysis; D015226:Dinucleoside Phosphates / Q000737:chemistry; D006868:Hydrolysis; D007700:Kinetics; D008674:Metals, Rare Earth / Q000737:chemistry*; D012313:RNA / Q000737:chemistry*
chemical_list: D015226:Dinucleoside Phosphates; D008674:Metals, Rare Earth; C006412:adenylyl-(3'-5')-adenosine; C026519:uridine monophosphate-uridine; D012313:RNA