title: Protein kinase C modulation.
abstract: PKC-modulators represent valuable additions to the arsenal of anti-tumor agents. They act as antiproliferative agents and are useful in overcoming drug-resistance by inhibiting mdr-mediated drug efflux. They increase the cytotoxicity to platinum complexes (and other DNA-damaging agents), probably by interfering with drug-induced detoxification and repair mechanisms. PKC-modulators are potentially active in overcoming ras-induced cis-platinum-resistance by antagonizing p21ras functions.
authors.affiliation: Institute of Medical Chemistry and Biochemistry, University of Innsbruck, Austria.
authors.forename: H H
authors.initials: HH
authors.lastname: Grunicke
authors.forename: F
authors.initials: F
authors.lastname: Uberall
mesh_terms: D000970:Antineoplastic Agents / Q000494:pharmacology*; D006801:Humans; D011493:Protein Kinase C / Q000037:antagonists & inhibitors / Q000187:drug effects*
chemical_list: D000970:Antineoplastic Agents; D011493:Protein Kinase C