Long-term prostacyclin--treatment acts on the DNA and RNA content of rat gastric (antral and fundic) mucosa dose-dependently.
The changes in gastric (antral and fundic) mucosal DNA and RNA contents were investigated in long-term (80 days) treatment of rats with orally administered prostacyclin. Prostacyclin caused a dose-dependent, significant increase of the DNA levels in both parts of the gastric mucosa together with a significant thickening of the fundic mucosa. The observed changes (decrease) of the RNA/DNA ratio in the fundic as well as antral mucosa, are interpreted as a sign of accelerated cell renewal, i.e. hyperplasia.
Bálint
G A
GA
Dept. of Neurology and Psychiatry, Albert Szent-Györgyi Medical University, Szeged, Hungary.
Karácsony
G
G
D000818:Animals; D001835:Body Weight / Q000187:drug effects; D004247:DNA / Q000378:metabolism*; D004305:Dose-Response Relationship, Drug; D011464:Epoprostenol / Q000494:pharmacology*; D005260:Female; D005748:Gastric Fundus; D005753:Gastric Mucosa / Q000166:cytology / Q000187:drug effects / Q000378:metabolism*; D011706:Pyloric Antrum; D012313:RNA / Q000378:metabolism*; D051381:Rats; D017208:Rats, Wistar
D012313:RNA; D004247:DNA; D011464:Epoprostenol