title: [Cytogenetics of neuroblastoma and glioma].
abstract: Without having the common high specific marker, the tumours of the nervous system are, however, characterized by regular quantitative and structural changes of chromosomes. In this review molecular and genetic aspects of chromosome translocations typical for the main types of the nervous system, their role in activation of protooncogenes and their conversion to oncogenes, which is able to cause tumor transformation, are considered. Additionally, the role of chromosome translocation in the inactivation of suppressor genes is discussed.
authors.forename: N V
authors.initials: NV
authors.lastname: Chudinovskaia
mesh_terms: D000818:Animals; D017353:Gene Deletion; D015972:Gene Expression Regulation, Neoplastic / Q000235:genetics*; D015321:Gene Rearrangement / Q000235:genetics; D005910:Glioma / Q000235:genetics*; D009447:Neuroblastoma / Q000235:genetics*; D014178:Translocation, Genetic / Q000235:genetics*
vernacular_title: Tsitogenetika neĭroblastomy i gliomy.