title: Alcohol-induced sinus bradycardia and hypotension in patients with syncope.
abstract: We observed 2 cases of repeated episodes of syncope after alcohol ingestion. Both patients were light drinkers and had carotid sinus hypersensitivity. In both cases, alcohol loading tests repeatedly induced sinus bradycardia and hypotension 1.0-1.5 hours after drinking alcohol. Atropine was effective in improving symptoms. A loading test using a glucose solution of equivalent osmolarity and volume was negative. Acute alcohol ingestion usually increases heart rate with variable effects on blood pressure. However, our 2 cases exhibited unusual alcohol-induced sinus bradycardia and hypotension, suggesting a paradoxical increase in parasympathetic activity and/or decrease in sympathetic activity.
authors.affiliation: Department of Cardiology, Iizuka Hospital, Fukuoka, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Tsutsui
authors.forename: T
authors.initials: T
authors.lastname: Matsuguchi
authors.forename: H
authors.initials: H
authors.lastname: Tsutsui
authors.forename: T
authors.initials: T
authors.lastname: Yoshida
authors.forename: S
authors.initials: S
authors.lastname: Yoshihara
authors.forename: K
authors.initials: K
authors.lastname: Yamamoto
authors.forename: R
authors.initials: R
authors.lastname: Hisanou
authors.forename: H
authors.initials: H
authors.lastname: Shimokawa
authors.forename: S
authors.initials: S
authors.lastname: Okamatsu
mesh_terms: D000368:Aged; D001146:Arrhythmia, Sinus / Q000139:chemically induced* / Q000503:physiopathology; D001919:Bradycardia / Q000139:chemically induced* / Q000503:physiopathology; D004562:Electrocardiography; D000431:Ethanol / Q000009:adverse effects*; D006801:Humans; D007022:Hypotension / Q000139:chemically induced*; D008297:Male; D008875:Middle Aged; D013575:Syncope / Q000139:chemically induced*
chemical_list: D000431:Ethanol