PSK (krestin) potentiates chemotherapeutic effects of tamoxifen on rat mammary carcinomas.
A total of 20 mg of 7,12-dimethylbenz[a]anthracene (DMBA) was administered orally to 41 female Sprague-Dawley (SD) rats (control group), and 60 mg/kg of Krestin (PSK) were orally administered daily to 38 rats (PSK group) after DMBA administration. The average development period (9.6 weeks) of DMBA-induced tumors in the PSK group was significantly longer (P < 0.02) than that (7.9 weeks) in the control group. Average estrogen receptor (ER) levels of established tumors were almost the same between these two groups. However, the chemotherapeutic effect of tamoxifen (TAM) was significantly enhanced by PSK pretreatment.
Iino
Y
Y
Second Departmen of Surgery, Gunma University School of Medicine, Japan.
Takai
Y
Y
Sugamata
N
N
Morishita
Y
Y
D015127:9,10-Dimethyl-1,2-benzanthracene; D000230:Adenocarcinoma / Q000139:chemically induced / Q000188:drug therapy* / Q000473:pathology / Q000517:prevention & control; D000818:Animals; D000903:Antibiotics, Antineoplastic / Q000627:therapeutic use*; D016588:Anticarcinogenic Agents / Q000627:therapeutic use*; D004357:Drug Synergism; D005260:Female; D008325:Mammary Neoplasms, Experimental / Q000139:chemically induced / Q000188:drug therapy* / Q000473:pathology / Q000517:prevention & control; D011509:Proteoglycans / Q000627:therapeutic use*; D051381:Rats; D017207:Rats, Sprague-Dawley; D011960:Receptors, Estrogen / Q000032:analysis; D013629:Tamoxifen / Q000627:therapeutic use*
D000903:Antibiotics, Antineoplastic; D016588:Anticarcinogenic Agents; D011509:Proteoglycans; D011960:Receptors, Estrogen; D013629:Tamoxifen; C010770:polysaccharide-K; D015127:9,10-Dimethyl-1,2-benzanthracene