[Antimutagenic properties of substances containing beta-carotene].
Two carotene-containing drugs (natural and artificial) were shown to decrease the rate of chromosomal aberrations, induced by cyclophosphane, in bone marrow cells of mice, daily ration of which contained 10-20 mg/kg of beta-carotene within 1-3 weeks. The rate of chromosomal aberrations induced was decreased 1.5-2-fold in various experiments. Artificial beta-carotene exhibited aftereffect within at least 3 days, while its protective effect was decreased about by 20% within 7 days after administration.
Shliankevich
M A
MA
Drize
O B
OB
Khabibulina
V M
VM
Sergeev
A V
AV
Privalova
E G
EG
Nikitiuk
V G
VG
D000818:Animals; D016587:Antimutagenic Agents / Q000737:chemistry / Q000494:pharmacology*; D001853:Bone Marrow / Q000187:drug effects; D002338:Carotenoids / Q000032:analysis / Q000737:chemistry / Q000494:pharmacology*; D002869:Chromosome Aberrations; D003520:Cyclophosphamide / Q000633:toxicity; D008297:Male; D051379:Mice; D008808:Mice, Inbred CBA; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology; D019207:beta Carotene
D016587:Antimutagenic Agents; D010936:Plant Extracts; D019207:beta Carotene; C080497:lipochromin; D002338:Carotenoids; D003520:Cyclophosphamide
Antimutagennye svoĭstva preparatov, soderzhashchikh beta-karotin.