title: Temporal frequency dependent adaptation at the level of the outer retina in humans.
abstract: The focal electroretinogram (FERG) was used to examine temporal frequency tuning at the outer retinal level in humans by measuring temporal modulation thresholds. Changes in FERG thresholds as a function of ambient light level were compared to temporal modulation thresholds obtained psychophysically using the same stimuli. At lower temporal frequencies, both FERG and psychophysical thresholds changed sensitivity proportional to the mean illuminance level. At higher illuminance levels, both threshold measures were relatively independent of illuminance. The comparison of the FERG to the behavioral data suggest that most of the adaptation-dependent changes in temporal sensitivity in humans occur at the level of the photoreceptor complex.
authors.affiliation: New York University Medical Center, Department of Ophthalmology, NY 10016.
authors.forename: W
authors.initials: W
authors.lastname: Seiple
authors.forename: K
authors.initials: K
authors.lastname: Holopigian
authors.forename: V
authors.initials: V
authors.lastname: Greenstein
authors.forename: D C
authors.initials: DC
authors.lastname: Hood
mesh_terms: D000221:Adaptation, Ocular; D000328:Adult; D004594:Electrophysiology; D004596:Electroretinography; D006801:Humans; D008027:Light; D010786:Photoreceptor Cells / Q000502:physiology*; D011603:Psychophysiology; D012684:Sensory Thresholds