title: [Biologically active substances from the skin that influence the proliferation and differentiation of cultured human keratinocytes].
abstract: Three fractions of biologically active substances of human skin varying in molecular weight (F1 > 15 kD, F2 1.4-15 kD, F3 < 1.4 kD) were tested in primary and regenerating cultures of human epidermal keratinocytes. F1 and F3 caused stimulation of keratinocyte proliferation, F2 inhibited proliferation and enhanced terminal differentiation of epidermal cells.
authors.forename: Iu M
authors.initials: IuM
authors.lastname: Lopukhin
authors.forename: V Ia
authors.initials: VIa
authors.lastname: Arion
authors.forename: V F
authors.initials: VF
authors.lastname: Ivanova
authors.forename: O V
authors.initials: OV
authors.lastname: Belova
authors.forename: A B
authors.initials: AB
authors.lastname: Kapitanov
mesh_terms: D002454:Cell Differentiation / Q000187:drug effects; D002455:Cell Division / Q000187:drug effects; D002470:Cell Survival / Q000187:drug effects; D002478:Cells, Cultured / Q000166:cytology / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D006133:Growth Substances / Q000494:pharmacology*; D006801:Humans; D015603:Keratinocytes / Q000166:cytology / Q000187:drug effects*; D008970:Molecular Weight; D012879:Skin Physiological Phenomena
chemical_list: D006133:Growth Substances
vernacular_title: Biologicheski aktivnye veshchestva kozhi, vliiaiushchie na proliferatsiiu i differentsirovku kul'tiviruemykh keratinotsitov cheloveka.