title: [Results of a randomized, double blind prospective study of intravesical chemoprophylaxis with 2 drugs: adriamycin and mitomycin; and 2 ways of initiating the instillations: early and late. Effect on recurrence and progression].
abstract: The results of a double blind prospective study comparing the chemoprophylactic effects of adriamycin and mitomycin C and two modes of instillation (early: 6 hours following transurethral resection; late: 7-14 days later) for superficial carcinoma of the bladder are presented herein. Since the minimum follow up is over 5 years, the effects on tumor progression and mortality achieved by each of the 4 arms of the protocol were also evaluated. Concerning tumor recurrence, early instillation of mitomycin and overall early instillation therapy achieved significantly better results (p < 0.01). No differences, however, were observed relative to tumor progression or mortality.
authors.affiliation: Instituto Valenciano de Oncología, Servicio de Urología, Valencia, España.
authors.forename: I
authors.initials: I
authors.lastname: Iborra Juan
authors.forename: J V
authors.initials: JV
authors.lastname: Ricos Torrent
authors.forename: J L
authors.initials: JL
authors.lastname: Monrós Lliso
authors.forename: R
authors.initials: R
authors.lastname: Dumont Martínez
authors.forename: J
authors.initials: J
authors.lastname: Casanova Ramón-Borja
authors.forename: E
authors.initials: E
authors.lastname: Solsona Narbón
mesh_terms: D000283:Administration, Intravesical; D002295:Carcinoma, Transitional Cell / Q000188:drug therapy* / Q000601:surgery; D003131:Combined Modality Therapy; D004311:Double-Blind Method; D004317:Doxorubicin / Q000627:therapeutic use*; D004334:Drug Administration Schedule; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D008937:Mitomycins / Q000627:therapeutic use*; D009364:Neoplasm Recurrence, Local / Q000517:prevention & control*; D011446:Prospective Studies; D013997:Time Factors; D001749:Urinary Bladder Neoplasms / Q000188:drug therapy* / Q000601:surgery
chemical_list: D008937:Mitomycins; D004317:Doxorubicin
vernacular_title: Resultados de un estudio de quimioprofilaxis intravesical, prospectivo, doble aleatorio, entre dos drogas: la adriamicina y el mitomicin; y dos modos de iniciar las instilaciones: precoz y tardío. Efecto sobre la recidiva y la progresión.