title: [Clinical and experimental study of Ligusticum wallichii and aspirin in the treatment of transient ischemic attack].
abstract: This paper reports the results of the treatment of 158 cases with transient ischemic attack (TIA). They were randomly divided into Ligusticum wallichii group (111 cases) and Aspirin group (47 cases). The results showed that the total effective rate in Ligusticum wallichii group and in Aspirin group were 89.2% and 61.7% respectively. The effect of former on the treatment of TIA was superior to latter, and the difference between them was significant (P < 0.01). Experimental study showed that Ligusticum wallichii has the effects of increasing cerebral blood flow, accelerating the velocity of blood flow, dilating the spastic artery and decreasing peripheral arterial resistance. Both of them has the functions of decreasing the levels of thromboxane B2(TXB2), beta-thromboglobulin (beta-TG) and platelet factor IV (PF4) in plasma and increasing the concentration of 6-keto-prostaglandin F1 alpha (6 keto-PGF1 alpha) in plasma, the effect of Ligusticum wallichii was significantly better than Aspirin (P < 0.05).
authors.affiliation: Dept. of Neurology, Changhai Hospital, 2nd Military Medical College, Shanghai.
authors.forename: D R
authors.initials: DR
authors.lastname: Chen
mesh_terms: D000284:Administration, Oral; D000368:Aged; D000818:Animals; D001241:Aspirin / Q000008:administration & dosage / Q000627:therapeutic use*; D004365:Drugs, Chinese Herbal / Q000008:administration & dosage / Q000627:therapeutic use*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D002546:Ischemic Attack, Transient / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged
chemical_list: D004365:Drugs, Chinese Herbal; D001241:Aspirin