Effects of sulglycotide on endogenous prostaglandin synthesis in human antral mucosa.
The effect of sulglycotide, a polysulphated glycopeptide isolated from pig duodenum, on PGE2, 6-ketoPGF1 alpha and TxB2 production from isolated biopsy specimens of human antral mucosa was investigated in vitro, in comparison with carbenoxolone. In addition to a tendency toward increased PGE2 production just short of statistical significance, both sulglycotide and carbenoxolone significantly increased 6-ketoPGF1 alpha accumulation in the incubation medium. TxB2 levels were not significantly modified by the two drugs. Therefore, changes in the prostanoid production by human antral mucosa could, at least partially account for the cytoprotective effects of sulglycotide in man.
Calabrò
A
A
Department of Clinical Pathophysiology, University of Florence, Italy.
Orsini
B
B
Milani
S
S
Psilogenis
M
M
Surrenti
C
C
D015121:6-Ketoprostaglandin F1 alpha / Q000096:biosynthesis; D000328:Adult; D000818:Animals; D000897:Anti-Ulcer Agents / Q000494:pharmacology*; D002229:Carbenoxolone / Q000494:pharmacology; D015232:Dinoprostone / Q000096:biosynthesis; D004386:Duodenum / Q000187:drug effects / Q000378:metabolism; D005260:Female; D005750:Gastric Juice / Q000187:drug effects / Q000378:metabolism; D005753:Gastric Mucosa / Q000187:drug effects / Q000378:metabolism*; D006801:Humans; D007124:Immunoenzyme Techniques; D066298:In Vitro Techniques; D008297:Male; D011453:Prostaglandins / Q000096:biosynthesis*; D011706:Pyloric Antrum / Q000187:drug effects / Q000378:metabolism; D012795:Sialoglycoproteins / Q000494:pharmacology*; D013552:Swine; D013929:Thromboxane B2 / Q000096:biosynthesis
D000897:Anti-Ulcer Agents; D011453:Prostaglandins; D012795:Sialoglycoproteins; C009354:sulglicotide; D013929:Thromboxane B2; D015121:6-Ketoprostaglandin F1 alpha; D015232:Dinoprostone; D002229:Carbenoxolone