Effects of inspired oxygen concentration on in vivo redox reaction of nitroxide radicals in whole mice.
Effects of inspired oxygen concentration on metabolism of nitroxide radical were measured in whole mice by using in vivo ESR. Oxygen concentration influenced spin-clearance of nitroxide differently in abdomen and head, suggesting that either O2 concentrations or metabolic mechanisms of nitroxide in the two domains were different.
Miura
Y
Y
Department of Health Chemistry, School of Pharmaceutical Sciences, Showa University, Tokyo, Japan.
Utsumi
H
H
Hamada
A
A
D000818:Animals; D003497:Cyclic N-Oxides / Q000378:metabolism* / Q000493:pharmacokinetics; D004578:Electron Spin Resonance Spectroscopy; D005260:Female; D005609:Free Radicals; D001239:Inhalation; D008657:Metabolic Clearance Rate; D051379:Mice; D008815:Mice, Inbred Strains; D010084:Oxidation-Reduction; D010100:Oxygen / Q000378:metabolism*; D013113:Spin Labels; D013997:Time Factors; D014018:Tissue Distribution
D003497:Cyclic N-Oxides; D005609:Free Radicals; D013113:Spin Labels; C047253:3-carbamoyl-2,2,5,5-tetramethyl-3-pyrroline-1-yloxyl; D010100:Oxygen; C001803:tempol