[Neuropeptide Y and heart failure].
A time course (48 hours) of plasma neuropeptide Y (NPY) levels has been carried out in a male, 66 years old, admitted to Coronary Care Unit with inferior acute myocardial infarction within 1 hour from the onset of chest pain. On admission an increase of plasma NPY levels (38 pg/ml) has been observed. The plasma NPY value decreased to normal range (15-25 pg/ml) within 12 hours and increased again (53 pg/ml) within 12 and 24 hours. A decrease in plasma NPY values to normal range has been observed within the second day in the Coronary Care Unit. A clearcut diuresis decrease, without pulmonary signs of heart failure, was present from 12 to 24 hours followed by marked polyuria within the second day. These data point out a relative importance of NPY in the diuresis adjustments. Thus, plasma NPY measurement might be a more reliable prognostic indicator of heart failure than plasma catecholamine levels. However, further investigations have to be performed.
Bastagli
L
L
Istituto di Patologia Speciale Medica e Metodologia Clinica, Università degli Studi, Bologna.
Degiovanni
M
M
Vallar
G
G
Zambrini
L
L
Pepe
G
G
De Iasio
R
R
Boschi
S
S
Puddu
P
P
D000368:Aged; D003325:Coronary Care Units; D004630:Emergencies; D006801:Humans; D007558:Italy; D008297:Male; D009203:Myocardial Infarction / Q000097:blood*; D009478:Neuropeptide Y / Q000097:blood*
D009478:Neuropeptide Y
Neuropeptide Y e scompenso cardiaco.