[Is localization of B-cells in the acini a normal condition or the sign of compensatory process in insulin-dependent diabetes mellitus?].
45 pancreatic biopsies from patients with insulin-dependent diabetes mellitus (IDDM), obtained in the process of surgical treatment were studied. A different degree of the Langerhans islands and morphological changes in B-cells was noted. The presence of endocrine-like cells in the acini and among the cells of the inter-acinar duct is of great interest. The granules of these cells were insulin-positive when studied immunohistochemically this permitting one to consider them as B-cells. Further study of these cells will allow to deepen the knowledge about the mechanism of IDDM development and to improve the methods of treatment.
Severgina
E S
ES
Diuzheva
T G
TG
Razgulina
L E
LE
Stakheev
I B
IB
D000293:Adolescent; D000328:Adult; D001402:B-Lymphocytes / Q000473:pathology*; D001706:Biopsy; D002648:Child; D002675:Child, Preschool; D003922:Diabetes Mellitus, Type 1 / Q000473:pathology*; D005260:Female; D006801:Humans; D008297:Male; D010179:Pancreas / Q000473:pathology*
Lokalizatsiia B-kletok v atsinusakh--obychnoe iavlenie ili priznak kompensatornogo protsessa pri insulinzavisimom sakharom diabete?