[Blood levels of cortisol and prolactin. Are they indices of the degree of protection against surgical stress?].
The paper evaluates the level of analgesic protection by assaying cortisol and prolactin levels in two groups of 20 patients each undergoing general anesthesia using two different techniques: TIVA with propofol and fentanyl, and BPN-nitrous oxide. The results showed that TIVA caused a very slight increase in residue cortisol which was, however, within normal limits. With BPN-nitrous oxide anesthesia there was a greater increase in cortisol, reaching a statistically significant level in blood collected one hour after the end of surgery. With regard to prolactin, there was a marked increase in this hormone using both techniques although in percentage terms this increase was lower in TIVA. These results show that plasma prolactin is a more sensitive test than cortisol assay in evaluating antalgic protection and that, of the two anesthetic techniques used, the most protective appears to be TIVA with propofol and fentanyl.
Riverso
P
P
Ospedale Saint Charles, Bordighera (Imperia), Regione Liguria, USL n. 1.
Launo
C
C
Bonilauri
M
M
Faraldi
C
C
Federici
E
E
Napoleone
M
M
Palermo
S
S
Alpa
E
E
D000328:Adult; D000368:Aged; D000698:Analgesia; D000758:Anesthesia; D002047:Buprenorphine; D005260:Female; D005283:Fentanyl; D006801:Humans; D006854:Hydrocortisone / Q000097:blood*; D008297:Male; D008875:Middle Aged; D009609:Nitrous Oxide; D011388:Prolactin / Q000097:blood*; D015742:Propofol; D013312:Stress, Physiological / Q000097:blood* / Q000517:prevention & control; D013514:Surgical Procedures, Operative
D002047:Buprenorphine; D011388:Prolactin; D009609:Nitrous Oxide; D005283:Fentanyl; D006854:Hydrocortisone; D015742:Propofol
Livelli ematici di cortisolo e prolattina. Indici del grado di protezione dallo stress chirurgico?