[The effect of the long-term treatment with calcium antagonists on myocardial function in patients with hypertension].
Prolonged effect (6-12 months) of verapamil and nifedipine on the systolic and diastolic function of the myocardium was studied in 48 patients with hypertensive disease (stage II). It was established that in patients with a high ejection fraction (55% and more) the two drugs produce a distinct reduction of the pumping heart function. The two drugs increase the rate of early diastolic filling. They also may reduce the arterial pressure via different hemodynamic mechanisms: vasodilatation or via reduction of cardiac output.
Svishchenko
E P
EP
Korchinskaia
O I
OI
Stroganova
N P
NP
Radchenko
V V
VV
D000328:Adult; D002121:Calcium Channel Blockers / Q000627:therapeutic use*; D004341:Drug Evaluation; D006321:Heart / Q000187:drug effects* / Q000503:physiopathology; D006439:Hemodynamics / Q000187:drug effects; D006801:Humans; D006973:Hypertension / Q000188:drug therapy* / Q000503:physiopathology; D009543:Nifedipine / Q000008:administration & dosage; D013997:Time Factors; D014700:Verapamil / Q000008:administration & dosage
D002121:Calcium Channel Blockers; D014700:Verapamil; D009543:Nifedipine
Vliianie dlitel'nogo lecheniia antagonistami kal'tsiia na funktsional'noe sostoianie miokarda u bol'nykh gipertonicheskoĭ bolezn'iu.