Inhibition of proliferation of tumour cell cultures by biologically active substances isolated from the tissues of Fasciola hepatica and Fasciola hepatica-infected rat liver.
Biologically active substances (BAS) were isolated from the tissues of Fasciola hepatica L. and from F. hepatica-infected rat liver by ethanol precipitation from aqueous tissue homogenates. A marked inhibiting effect of the newly isolated BAS on hepatoma MC29 cell culture proliferation and a slight inhibiting effect of the newly isolated BAS on myeloma cell culture proliferation was found. The strongest inhibiting effect was by BAS isolated from the tissues of F. hepatica. The inhibiting effect of the BAS isolated from F. hepatica-infected liver was stronger than the effect of the BAS isolated from normal liver tissue.
Tsocheva
N
N
Institute of Parasitology, Bulgarian Academy of Sciences, Sofia.
Toshkova
R
R
Filchev
A
A
D000818:Animals; D002455:Cell Division; D002645:Chickens; D006224:Cricetinae; D004273:DNA, Neoplasm / Q000096:biosynthesis; D005210:Fasciola hepatica / Q000502:physiology*; D005211:Fascioliasis / Q000378:metabolism*; D006131:Growth Inhibitors / Q000302:isolation & purification / Q000502:physiology*; D008099:Liver / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar; D014407:Tumor Cells, Cultured / Q000378:metabolism / Q000473:pathology*
D004273:DNA, Neoplasm; D006131:Growth Inhibitors