Thyrotropin-secreting pituitary microadenoma.
We present a 45-yr-old male with clinical signs and symptoms of mild hyperthyroidism, high serum levels of T3, T4, and FT4 as well as serum TSH concentration. The elevated alpha-subunit level and alpha-subunit/TSH molar ratio were also observed. These findings indicated the presence of hyperthyroidism due to inappropriate secretion of TSH, whose neoplastic origin was documented by nuclear magnetic resonance scan showing a 0. 6 cm pituitary adenoma. Selective pituitary adenomectomy was completely successful; alpha-subunit, TSH, T3, T 4, and FT4 normalized, and euthyroidism was restored. Light microscopic immunohistochemistry showed that the adenoma was composed of TSH-secreting cells.
Lee
E J
EJ
Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea.
Kim
K R
KR
Lee
K M
KM
Yoon
D H
DH
Kim
Y S
YS
Kim
D I
DI
Jung
W H
WH
Chung
Y S
YS
Lim
S K
SK
Lee
H C
HC
D000236:Adenoma / Q000175:diagnosis / Q000378:metabolism* / Q000473:pathology; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D010911:Pituitary Neoplasms / Q000175:diagnosis / Q000378:metabolism* / Q000473:pathology; D013972:Thyrotropin / Q000378:metabolism*
D013972:Thyrotropin