title: [Evaluation of the effectiveness of cisapride in the treatment of gastroesophageal reflux].
abstract: To evaluate the effectiveness of administration of oral cisapride in patients with gastro-esophageal reflux, we studied 25 children, aged 1 month-7 years (mean 16.2 months) affected with GER. At the time of diagnosis and 8 weeks after treatment, patients were clinically evaluated and underwent a 24-hour continuous esophageal pH-monitoring. After treatment a complete regression of symptoms was observed in 20/25 patients. Moreover we recorded a significant reduction in the percentage of reflux time (p < 0.0001) and in the Jolley score (p < 0.0001), a very accurate scoring system to evaluate the pH-metric tracing, after treatment. It is concluded that cisapride is a useful agent both for the relief of symptoms and for the improvement of pH-metric parameters in children with GER disease.
authors.affiliation: IV Divisione Lattanti, USL 58, Ospedale Di Cristina - Palermo.
authors.forename: G
authors.initials: G
authors.lastname: Iacono
authors.forename: A
authors.initials: A
authors.lastname: Carroccio
authors.forename: G
authors.initials: G
authors.lastname: Montalto
authors.forename: F
authors.initials: F
authors.lastname: Cavataio
authors.forename: D
authors.initials: D
authors.lastname: Lorello
authors.forename: M
authors.initials: M
authors.lastname: Soresi
authors.forename: I
authors.initials: I
authors.lastname: Kazmierska
authors.forename: V
authors.initials: V
authors.lastname: Balsamo
mesh_terms: D002648:Child; D002675:Child, Preschool; D020117:Cisapride; D005069:Evaluation Studies as Topic; D005260:Female; D005764:Gastroesophageal Reflux / Q000188:drug therapy*; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D010880:Piperidines / Q000627:therapeutic use*; D017367:Selective Serotonin Reuptake Inhibitors / Q000627:therapeutic use*
chemical_list: D020117:Cisapride; D010880:Piperidines; D017367:Selective Serotonin Reuptake Inhibitors
vernacular_title: Valutazione dell'efficacia della cisapride nel trattamento del reflusso gastro-esofageo.