[Effect of yizhiling granule on experimental pathological model of Alzheimer's disease].
Alzheimer's disease is an important problem of gerontology which manifested as serious loss of memory, especially of recent memory, decrease of brain weight. The pathological model of the disease in mice was made with administration of AlCl3 and then Yizhiling Granule was given to treat it.


RESULTS
In the experiment of one trial passive avoidance response there were significant difference between the normal group and the model group (P < 0.01) and significant difference between the treated group and the model group (P < 0.05-0.01); as for fresh brain weight, the treated group was significantly different from the normal group (P < 0.01) and model group (P < 0.05). They indicate that Yizhiling Granule could improve memory and increase brain weight. This research seems to provide experimental basis for treatment of the disease.
Wi
Z M
ZM
Hunan College of TCM, Changsha.
Peng
J L
JL
D000535:Aluminum; D000544:Alzheimer Disease / Q000139:chemically induced / Q000188:drug therapy* / Q000473:pathology; D000818:Animals; D001921:Brain / Q000187:drug effects / Q000473:pathology*; D002712:Chlorides; D004365:Drugs, Chinese Herbal / Q000494:pharmacology* / Q000627:therapeutic use; D005260:Female; D008297:Male; D008570:Memory, Short-Term / Q000187:drug effects*; D051379:Mice; D009929:Organ Size / Q000187:drug effects; D005894:Panax; D010946:Plants, Medicinal
D002712:Chlorides; D004365:Drugs, Chinese Herbal; D000535:Aluminum