Scoparic acid A, a beta-glucuronidase inhibitor from Scoparia dulcis.
The 70% EtOH extract of Scoparia dulcis showed inhibitory activity against beta-glucuronidase from bovine liver. Bioassay-directed fractionation of the active extract led to the isolation of three labdane-type diterpene acids, scoparic acid A [1] [6-benzoyl-12-hydroxy-labda-8(17), 13-dien-18-oic acid], scoparic acid B [2] [6-benzoyl-14,15-dinor-13-oxo-8(17)-labden-18-oic acid], and scoparic acid C [3] [6-benzoyl-15-nor-14-oxo-8(17)-labden-18-oic acid], the structures of which were established by spectral means, including X-ray analysis. Scoparic acid A was found to be a potent beta-glucuronidase inhibitor.
Hayashi
T
T
Faculty of Pharmaceutical Sciences, Toyama Medical and Pharmaceutical University, Japan.
Kawasaki
M
M
Okamura
K
K
Tamada
Y
Y
Morita
N
N
Tezuka
Y
Y
Kikuchi
T
T
Miwa
Y
Y
Taga
T
T
D000107:Acetylation; D003460:Crystallization; D004224:Diterpenes / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D005966:Glucuronidase / Q000037:antagonists & inhibitors*; D009682:Magnetic Resonance Spectroscopy; D008745:Methylation; D008968:Molecular Conformation; D010239:Paraguay; D010946:Plants, Medicinal / Q000737:chemistry*; D014961:X-Ray Diffraction
D004224:Diterpenes; C055030:scoparic acid A; D005966:Glucuronidase