[Two cases of severe cutaneous vasculitis with thrombocytopenia associated with hepatic cirrhosis: autoimmune and infective-inflammatory component with endothelial lesion and restrictive pulmonary pattern in one case].
Two clinical cases of female patients with hepatic cirrhosis and autoimmune multisystemic involvement with infectious intercurrent are reported. Case 1 presented infective endocarditis and erysipelas on the left thigh. In the course of the clinical picture a cutaneous vasculitis developed in the same place together with autoimmune thrombocytopenia, leukopenia and pulmonary restrictive picture with inflammatory pattern. There are also elevate immune complexes and complement consumption. Case 2 presented erysipelas on the left thigh cutaneous vasculitis and complement consumption. In Case 1 the infective endocarditis was treated with antibiotic therapy during 4 weeks followed by 1 mg/kg corticoid (Prednisone) with thrombocytopenia and leukopenia reversion. Case 2 presented an improvement with antibiotic only. The relation between chronic liver diseases and systemic autoimmune phenomena is commented, special attention being paid to the cutaneous, hematological and pulmonary affection.
de Andrade Júnior
D R
DR
Serviço de Clínica Geral e Propedêutica do Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo, HC-FMUSP.
Warth
M do P
Mdo P
Morrone
L F
LF
Calich
I
I
de Andrade
D R
DR
D000328:Adult; D001323:Autoantibodies / Q000032:analysis; D001327:Autoimmune Diseases / Q000150:complications* / Q000276:immunology; D004886:Erysipelas / Q000150:complications / Q000276:immunology; D005260:Female; D006801:Humans; D008103:Liver Cirrhosis / Q000150:complications* / Q000276:immunology; D008875:Middle Aged; D015985:Precipitating Factors; D013921:Thrombocytopenia / Q000150:complications* / Q000276:immunology; D018366:Vasculitis, Leukocytoclastic, Cutaneous / Q000150:complications* / Q000175:diagnosis / Q000276:immunology
D001323:Autoantibodies
Dois casos de vasculite cutânea grave com plaquetopenia associada à cirrose hepática: componente autoimune e infecto-inflamatório com lesão endotelial e padrão restritivo pulmonar em um caso.