[Chromosomal analysis of human squamous cell carcinoma of the larynx].
Twenty cases of human squamous cell carcinomas of larynx were processed with an improved direct chromosome preparations. Metaphases were obtained from 5 cases and detailed G-banding analyses were completed in 3 cases. In addition, a cell line of squamous cell carcinomas of larynx (HEP-2) was analyzed with high resolution banding technique. Three generations were cytogenetically analyzed (365, 375, 395). DM, which indicate gene amplification was found in case 4 and the cell line. 6q- and i (8q) appeared in both primary tumors and the cell line, and thus could be considered as characteristic changes in human squamous cell carcinomas of larynx.
Han
R Z
RZ
Second Affiliated Hospital, Haerbin Medical University.
D002294:Carcinoma, Squamous Cell / Q000235:genetics*; D002871:Chromosome Banding; D002896:Chromosomes, Human, Pair 6; D002898:Chromosomes, Human, Pair 8; D006801:Humans; D007621:Karyotyping; D007822:Laryngeal Neoplasms / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D014407:Tumor Cells, Cultured