title: Pharmacokinetics of mefloquine in children aged 6 to 24 months.
abstract: The study was carried out in 12 children aged 6 months to 2 years, with uncomplicated falciparum malaria admitted to the Hospital for Tropical Diseases, Bangkok. They were treated with mefloquine in the form of MSP (mefloquine 250 mg+sulfadoxine 500 mg+pyrimethamine 25 mg) at a single dose of 25 mg mefloquine base/kg body weight. All of them were cured (28 days follow-up) with minimal side effects. Pharmacokinetic parameter determination was carried out in 9 cases. The results revealed that MRT, t1/2 and tmax in this study (children 6-24 months old) are comparable to the values in children aged 5-12 years, but shorter than in adult patients. Cmax and AUC in children 6-24 months old are comparable to those in children of 5-12 years, but much higher than in adult patients. Vz/f values in this study are comparable to those in children 5-12 years old, but lower than in adult patients.
authors.affiliation: Department of Tropical Pediatrics, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand.
authors.forename: V
authors.initials: V
authors.lastname: Singhasivanon
authors.forename: T
authors.initials: T
authors.lastname: Chongsuphajaisiddhi
authors.forename: A
authors.initials: A
authors.lastname: Sabcharoen
authors.forename: P
authors.initials: P
authors.lastname: Attanath
authors.forename: H K
authors.initials: HK
authors.lastname: Webster
authors.forename: W H
authors.initials: WH
authors.lastname: Wernsdorfer
authors.forename: U K
authors.initials: UK
authors.lastname: Sheth
authors.forename: I
authors.initials: I
authors.lastname: Djaja Lika
mesh_terms: D000328:Adult; D000367:Age Factors; D002648:Child; D002675:Child, Preschool; D006801:Humans; D007223:Infant; D016778:Malaria, Falciparum / Q000188:drug therapy* / Q000378:metabolism; D015767:Mefloquine / Q000493:pharmacokinetics* / Q000627:therapeutic use
chemical_list: D015767:Mefloquine