Synthesis and property of alpha-oligodeoxynucleotide phosphorothioate.
Unnatural DNA analog, alpha-2'-deoxy-oligoadenylate phosphorothioate bearing 3'-normal monophosphate moiety was conveniently synthesized through phosphoramidite solid support method. The starting material of the DNA analog, alpha-2'-deoxyadenosine, was prepared in a stereospecific manner by the coupling reaction between activated nucleobase and 1-chloro-2-deoxyribose derivative.
Shinozuka
K
K
Department of Chemistry, Faculty of Engineering, Gunma University, Kiryu City, Japan.
Hirota
Y
Y
Morita
T
T
Sawai
H
H
D000227:Adenine Nucleotides / Q000138:chemical synthesis* / Q000737:chemistry; D003839:Deoxyadenosines / Q000737:chemistry; D015394:Molecular Structure; D013873:Thionucleotides / Q000138:chemical synthesis* / Q000737:chemistry
D000227:Adenine Nucleotides; D003839:Deoxyadenosines; D013873:Thionucleotides