[Magnifying endoscopic observation on the effect of a proton pump inhibitor on the healing process of gastric ulcer].
The effect of a proton pump inhibitor on the healing process of gastric ulcer was investigated through magnifying endoscopic observation of the regenerated mucosa. The findings were the same obtained as those by stereoscopic microscopic observation of the effect of conventional drugs. Namely, a structureless red area consisting of one layer of regenerated epithelium was the first to procede forward the ulcer base, and a radially arranged roughly striated pattern of regenerated mucosa, in which gastric glands were formed. The regenerated mucosa changed from a striated to a granular pattern. In a shallow ulcer, the ulcer scar showed a fine gastric mucosal pattern similar to that of the surrounding area. The strong inhibition of gastric acid secretion by a proton pump inhibitor is believed to raise no problems in the healing process of peptic ulcer. The magnifying endoscopic observation also disclosed that the protruding granulation disappeared gradually and changed to concave regenerated epithelium, suggesting that the ulcer base protrusion, which has been considered as an adverse effect of strong acid secretion inhibitors, has no influence on the healing of the ulcer.
Sakaki
N
N
Internal Medicine, Tokyo Metropolitan Komagome Hospital.
D000251:Adenosine Triphosphatases / Q000037:antagonists & inhibitors*; D000368:Aged; D005260:Female; D005753:Gastric Mucosa / Q000502:physiology / Q000648:ultrastructure*; D005773:Gastroscopy; D017506:H(+)-K(+)-Exchanging ATPase; D006801:Humans; D008297:Male; D008853:Microscopy; D008875:Middle Aged; D009853:Omeprazole / Q000494:pharmacology / Q000627:therapeutic use*; D012038:Regeneration; D013276:Stomach Ulcer / Q000188:drug therapy / Q000473:pathology*
D000251:Adenosine Triphosphatases; D017506:H(+)-K(+)-Exchanging ATPase; D009853:Omeprazole