Selective inhibition of in vitro cell growth by the anti-tumour drug Ukrain.
The inhibitory effect of Ukrain on malignant cells and on normal cells, in vitro, has been compared. To obtain a 50% inhibition of cell growth, a tenfold concentration had to be used with normal endothelial cells compared to a human osteosarcoma cell line. Hybrids of the two cell types showed nearly the same sensitivity as normal cells. A laser scanning microscope showed a high uptake of Ukrain in malignant cells, while the content in normal cells under the same experimental conditions was substantially lower.
Hohenwarter
O
O
Institute of Applied Microbiology, University of Agriculture, Vienna, Austria.
Strutzenberger
K
K
Katinger
H
H
Liepins
A
A
Nowicky
J W
JW
D000470:Alkaloids / Q000494:pharmacology*; D000972:Antineoplastic Agents, Phytogenic / Q000494:pharmacology*; D001600:Berberine Alkaloids; D002455:Cell Division / Q000187:drug effects; D004730:Endothelium, Vascular / Q000166:cytology; D006801:Humans; D006822:Hybrid Cells / Q000187:drug effects; D008545:Melanoma / Q000473:pathology; D008856:Microscopy, Fluorescence; D012516:Osteosarcoma / Q000473:pathology; D010617:Phenanthridines; D014407:Tumor Cells, Cultured / Q000187:drug effects
D000470:Alkaloids; D000972:Antineoplastic Agents, Phytogenic; D001600:Berberine Alkaloids; D010617:Phenanthridines; C060921:ukrain