[CD10(CALLA)-negative acute lymphoblastic leukemia. A group with a bad prognosis].
The results of 188 patients with acute lymphoblastic leukemia, studied between 1985 and 1990, showed that 8 cases were CD10 negative, Dr, and CD19 positive. These findings indicate cell dedifferentiation and poor prognosis. The patients age ranged from 2 to 30 years, with a mean of 11 years. The male/female ratio was 5/3. Lymph node enlargement and splenomegaly were found in the 8 patients. With the exception of one patient in whom leucopenia was present, the white cell counts were always higher than 30,000/dl. The karyotype was studied in four cases, and all of them were hyperdiploid. This is the first report in Venezuela of cases with acute lymphoblastic leukemia - CD 10 negative.
De Salvo
L
L
Instituto Hematológico de Occidente, Banco de Sangre del Estado Zulia, Maracaibo, Venezuela.
Plumacher
Z
Z
Ríos
M
M
Romero
E
E
Weir
J
J
Gómez
O
O
Salas
D
D
D000293:Adolescent; D000328:Adult; D000782:Aneuploidy; D000951:Antigens, Neoplasm / Q000032:analysis*; D014408:Biomarkers, Tumor / Q000032:analysis*; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D008198:Lymph Nodes / Q000473:pathology; D008297:Male; D015260:Neprilysin / Q000032:analysis*; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000097:blood / Q000145:classification* / Q000453:epidemiology / Q000235:genetics / Q000401:mortality; D011379:Prognosis; D013163:Splenomegaly / Q000209:etiology; D014687:Venezuela / Q000453:epidemiology
D000951:Antigens, Neoplasm; D014408:Biomarkers, Tumor; D015260:Neprilysin
Leucemia linfoblástica aguda CD10 (CALLA) negativo. Grupo de mal pronóstico.