Prospective study of Lewis antigen alterations in the gastric precancerous process.
A prospective study with two gastric biopsies taken several years apart was carried out in 117 subjects with intestinal metaplasia who are of the Lewis(a-b+) phenotype. They are residents of a rural Andean region in Colombia displaying very high rates of gastric cancer. The anomalous expression of Lewis(a) antigens in the metaplastic epithelium carried a significantly increased risk of colonic metaplasia and dysplasia. Such risk was much higher when the simultaneous expression of sulfomucins and Lewis(a) antigen was observed.
Torrado
J
J
Department of Anatomic Pathology, Hospital Nuestra Sra. de Aranzazu, San Sebastian, Spain.
Correa
P
P
Ruiz
B
B
Zavala
D
D
Bara
J
J
D000328:Adult; D000368:Aged; D014408:Biomarkers, Tumor / Q000235:genetics*; D001706:Biopsy; D003105:Colombia / Q000453:epidemiology; D005260:Female; D015870:Gene Expression; D006801:Humans; D007150:Immunohistochemistry; D007410:Intestinal Diseases / Q000453:epidemiology / Q000235:genetics / Q000473:pathology*; D007983:Lewis Blood Group Antigens / Q000235:genetics*; D008297:Male; D008679:Metaplasia; D008875:Middle Aged; D009077:Mucins / Q000235:genetics; D010641:Phenotype; D011230:Precancerous Conditions / Q000453:epidemiology / Q000235:genetics / Q000473:pathology*; D011446:Prospective Studies; D012307:Risk Factors; D012424:Rural Population; D012680:Sensitivity and Specificity; D013274:Stomach Neoplasms / Q000453:epidemiology / Q000235:genetics / Q000473:pathology*
D014408:Biomarkers, Tumor; D007983:Lewis Blood Group Antigens; D009077:Mucins; C012564:sulfomucin