title: Linkage of Tunisian autosomal recessive Duchenne-like muscular dystrophy to the pericentromeric region of chromosome 13q.
abstract: Autosomal recessive Duchenne-like muscular dystrophy (DLMD) is a severe dystrophic myopathy. The incidence is unknown because of its clinical similarity to Duchenne muscular dystrophy (DMD). Three highly inbred DLMD families from Tunisia were analysed for chromosomal linkage using 135 polymorphic microsatellite markers. A significant lod score of z = 9.15 at theta = 0.03 was found with the 13q12 locus D13S115. Two additional 13q12 markers, D13S143 and D13S120, also gave significant lod scores. Therefore, the primary DLMD defect gene lies in the pericentrometric region of chromosome 13q.
authors.affiliation: Department of Medicine, Duke University Medical Center, Durham, North Carolina 27710.
authors.forename: K
authors.initials: K
authors.lastname: Ben Othmane
authors.forename: M
authors.initials: M
authors.lastname: Ben Hamida
authors.forename: M A
authors.initials: MA
authors.lastname: Pericak-Vance
authors.forename: C
authors.initials: C
authors.lastname: Ben Hamida
authors.forename: S
authors.initials: S
authors.lastname: Blel
authors.forename: S C
authors.initials: SC
authors.lastname: Carter
authors.forename: A M
authors.initials: AM
authors.lastname: Bowcock
authors.forename: K
authors.initials: K
authors.lastname: Petruhkin
authors.forename: T C
authors.initials: TC
authors.lastname: Gilliam
authors.forename: A D
authors.initials: AD
authors.lastname: Roses
mesh_terms: D002503:Centromere / Q000648:ultrastructure; D002874:Chromosome Mapping; D002882:Chromosomes, Human, Pair 13 / Q000648:ultrastructure; D003241:Consanguinity; D004276:DNA, Satellite / Q000235:genetics; D005260:Female; D005808:Genes, Recessive; D008040:Genetic Linkage; D005819:Genetic Markers; D006801:Humans; D008297:Male; D009136:Muscular Dystrophies / Q000235:genetics*; D010375:Pedigree; D010641:Phenotype; D011110:Polymorphism, Genetic; D014416:Tunisia
chemical_list: D004276:DNA, Satellite; D005819:Genetic Markers