[The value of serum tumor-associated glycoprotein 72 (TAG 72) in the diagnosis of malignancies].
Serum TAG 72 concentrations of 110 normal subjects, 110 patients with benign diseases and 109 with malignant diseases were determined by a solid phase radioimmunoassay. Its levels in normal subjects were 1.6 +/- 1.5 u/ml (mean +/- SD, range 0-8.2 u/ml) and the cut-off limit was set at 4.6 u/ml. The positive rates in benign and malignant patients were 5.5% and 48.6%, respectively. Among the malignancies, 80.0% of ovarian and 63.6% of colon carcinomas had positive test results. The specificity for differentiating malignancies from benign diseases was 94.5% and the accuracy of diagnosis was 71.7%. The present study indicates that TAG 72 as a tumor marker is helpful in the diagnosis of malignancies.
Sun
G
G
PUMC Hospital, Beijing.
D000293:Adolescent; D000328:Adult; D000368:Aged; D000951:Antigens, Neoplasm / Q000097:blood*; D014408:Biomarkers, Tumor / Q000097:blood*; D001984:Bronchial Neoplasms / Q000097:blood; D003110:Colonic Neoplasms / Q000097:blood; D004067:Digestive System Neoplasms / Q000097:blood*; D005260:Female; D006023:Glycoproteins / Q000097:blood*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010051:Ovarian Neoplasms / Q000097:blood*
D000951:Antigens, Neoplasm; D014408:Biomarkers, Tumor; D006023:Glycoproteins; C047052:tumor-associated antigen 72