Vitamin C aspirin interactions in laboratory animals.
Ascorbic acid concentration has been determined in samples of plasma, leucocytes, urine, faeces and adrenal glands of guinea-pigs after administration of (i) 10, 25 or 100 mg ascorbic acid, (ii) 10 mg ascorbic acid plus 10, 25 or 50 mg aspirin and (iii) 25 mg aspirin and 25, 50 or 100 mg ascorbic acid. When the dose of aspirin was 25 mg or more, the transport of ascorbic acid into leucocytes was inhibited, the plasma concentration of vitamin C was elevated significantly and the excretion of ascorbic acid in the urine was increased in direct proportion to the aspirin dose. Ascorbic acid concentration in the adrenal glands was not significantly elevated after 3 h. When a constant dose of 25 mg of aspirin was given along with increasing doses of ascorbic acid both plasma and leucocyte ascorbic acid levels were elevated but not significantly after 2, 3 and 24 h. Urine ascorbic acid levels did not show any changes with the same doses.
Daş
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Department of Biochemistry, Faculty of Pharmacy, Ankara University, Turkey.
Nebioğlu
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S
D000311:Adrenal Glands / Q000378:metabolism; D000818:Animals; D001205:Ascorbic Acid / Q000097:blood / Q000494:pharmacology*; D001241:Aspirin / Q000494:pharmacology*; D001693:Biological Transport, Active / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D004347:Drug Interactions; D005243:Feces / Q000737:chemistry; D006168:Guinea Pigs; D007408:Intestinal Absorption / Q000187:drug effects; D007962:Leukocytes / Q000378:metabolism; D008297:Male
D001205:Ascorbic Acid; D001241:Aspirin