[Evaluation of the effectiveness of cisapride in the treatment of gastroesophageal reflux].
To evaluate the effectiveness of administration of oral cisapride in patients with gastro-esophageal reflux, we studied 25 children, aged 1 month-7 years (mean 16.2 months) affected with GER. At the time of diagnosis and 8 weeks after treatment, patients were clinically evaluated and underwent a 24-hour continuous esophageal pH-monitoring. After treatment a complete regression of symptoms was observed in 20/25 patients. Moreover we recorded a significant reduction in the percentage of reflux time (p < 0.0001) and in the Jolley score (p < 0.0001), a very accurate scoring system to evaluate the pH-metric tracing, after treatment. It is concluded that cisapride is a useful agent both for the relief of symptoms and for the improvement of pH-metric parameters in children with GER disease.
Iacono
G
G
IV Divisione Lattanti, USL 58, Ospedale Di Cristina - Palermo.
Carroccio
A
A
Montalto
G
G
Cavataio
F
F
Lorello
D
D
Soresi
M
M
Kazmierska
I
I
Balsamo
V
V
D002648:Child; D002675:Child, Preschool; D020117:Cisapride; D005069:Evaluation Studies as Topic; D005260:Female; D005764:Gastroesophageal Reflux / Q000188:drug therapy*; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D010880:Piperidines / Q000627:therapeutic use*; D017367:Selective Serotonin Reuptake Inhibitors / Q000627:therapeutic use*
D020117:Cisapride; D010880:Piperidines; D017367:Selective Serotonin Reuptake Inhibitors
Valutazione dell'efficacia della cisapride nel trattamento del reflusso gastro-esofageo.