Complement fixing antibodies against selected viruses in diabetic patients and non-diabetic control subjects in Ibadan, Nigeria.
Sera of forty insulin-treated Nigerian diabetics attending the outpatients clinic of the University College Hospital (U.C.H.), Ibadan, and an equal number of non-diabetic control subjects matched for age, sex and social status were tested for presence of complement fixing (CF) antibodies against five viruses: Coxsackie A and B1, mumps rubella and enterovirus group antigen. Antibody levels to Coxsackie B1, mumps, rubella and enterovirus did not show any significant difference between the two groups (P > 0.05). The serum levels of antibody to Coxsackie A virus were significantly higher in non-diabetic controls than in the diabetics (P < 0.05). Previous exposure to these viruses may not be a significant factor in the aetiology of insulin dependent diabetes mellitus in this environment.
Ajuwon
Z A
ZA
Department of Medicine, University College Hospital, Ibadan, Nigeria.
Olaleye
O D
OD
Omilabu
S A
SA
Baba
S S
SS
D000914:Antibodies, Viral / Q000097:blood*; D003168:Complement Fixation Tests; D003165:Complement System Proteins / Q000032:analysis*; D003922:Diabetes Mellitus, Type 1 / Q000209:etiology / Q000276:immunology*; D006801:Humans; D009549:Nigeria; D014777:Virus Diseases / Q000150:complications / Q000276:immunology
D000914:Antibodies, Viral; D003165:Complement System Proteins