[Changes in expression of interleukin-2 and interleukin-2 receptor in lymphocytes in patients with burns].
IL-2 mainly combines with the IL-2R on the membrane of the lymphocyte, both to promote activation and proliferation. The expression of IL-2 and IL-2R on the lymphocyte was found to be significantly depressed after burn injury. IL-2 was decreased by 40%-60%, and the expression of IL-2R was decreased by 25%-55%, especially on the 7th day after burn. The results demonstrated that burn injury not only influenced the production of IL-2 from T helper cell, but also depressed the expression of IL-2R.
Sun
S R
SR
Central Laboratory, 304th Hospital of PLA, Beijing.
D000328:Adult; D002056:Burns / Q000276:immunology*; D005260:Female; D006801:Humans; D007376:Interleukin-2 / Q000097:blood*; D008214:Lymphocytes / Q000276:immunology*; D008297:Male; D015375:Receptors, Interleukin-2 / Q000378:metabolism*
D007376:Interleukin-2; D015375:Receptors, Interleukin-2