title: X-linked glucose-6-phosphate dehydrogenase (G6PD) and autosomal 6-phosphogluconate dehydrogenase (6PGD) polymorphisms in baboons.
abstract: Electrophoretic polymorphisms of glucose-6-phosphate dehydrogenase (G6PD) and 6-phosphogluconate dehydrogenase (6PGD) were examined in captive colonies of five subspecies of baboons (Papio hamadryas). Phenotype frequencies and family data verified the X-linked inheritance of the G6PD polymorphism. Insufficient family data were available to confirm autosomal inheritance of the 6PGD polymorphism, but the electrophoretic patterns of variant types (putative heterozygotes) suggested the codominant expression of alleles at an autosomal locus. Implications of the G6PD polymorphism are discussed with regard to its utility as a marker system for research on X-chromosome inactivation during baboon development and for studies of clonal cell proliferation and/or cell selection during the development of atherosclerotic lesions in the baboon model.
authors.affiliation: Department of Genetics, Southwest Foundation for Biomedical Research, San Antonio, Texas 78228-0147.
authors.forename: J L
authors.initials: JL
authors.lastname: VandeBerg
authors.forename: M J
authors.initials: MJ
authors.lastname: Aivaliotis
authors.forename: P B
authors.initials: PB
authors.lastname: Samollow
mesh_terms: D000483:Alleles; D000818:Animals; D001161:Arteriosclerosis / Q000201:enzymology / Q000235:genetics; D015415:Biomarkers; D001797:Blood Protein Electrophoresis; D002999:Clone Cells / Q000201:enzymology; D004303:Dosage Compensation, Genetic; D005321:Extraembryonic Membranes / Q000201:enzymology; D005260:Female; D015971:Gene Expression Regulation, Enzymologic; D008040:Genetic Linkage; D005838:Genotype; D005954:Glucosephosphate Dehydrogenase / Q000097:blood / Q000235:genetics*; D006801:Humans; D010215:Papio / Q000097:blood / Q000145:classification / Q000235:genetics*; D010734:Phosphogluconate Dehydrogenase / Q000097:blood / Q000235:genetics*; D011110:Polymorphism, Genetic; D011247:Pregnancy; D013045:Species Specificity; D014960:X Chromosome
chemical_list: D015415:Biomarkers; D010734:Phosphogluconate Dehydrogenase; D005954:Glucosephosphate Dehydrogenase