title: [Long-term results of chymopapain chemonucleolysis].
abstract: Results of chemonucleolysis were evaluated (on the basis of residual pain, occupational activities, physical activities, and use of analgesics) in 125 of 162 consecutive patients with lower back pain and sciatica associated with documented vertebral disc protrusion who were managed and followed up for at least five years. Results were satisfactory in 62% of patients. Among 82 patients evaluated during a follow-up visit, 30% were free of symptoms, 38% had lower back pain, and 30% had radicular pain; however, among symptomatic patients, 67% had no limitations of activities of daily living. Results were significantly less favorable in power drill workers and in patients who had chemonucleolysis at the L4-L5 level. These data are evidence that chemonucleolysis provides good long-term results.
authors.affiliation: Services de Rhumatologie, Hôpital Trousseau, CHU Tours.
authors.forename: P
authors.initials: P
authors.lastname: Goupille
authors.forename: P
authors.initials: P
authors.lastname: Cotty
authors.forename: B
authors.initials: B
authors.lastname: Fouquet
authors.forename: C
authors.initials: C
authors.lastname: Anger
authors.forename: V
authors.initials: V
authors.lastname: Betheuil
authors.forename: J P
authors.initials: JP
authors.lastname: Valat
mesh_terms: D000328:Adult; D002917:Chymopapain / Q000627:therapeutic use*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007404:Intervertebral Disc Chemolysis; D007405:Intervertebral Disc Displacement / Q000150:complications / Q000628:therapy*; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D012585:Sciatica / Q000209:etiology / Q000628:therapy*
chemical_list: D002917:Chymopapain
vernacular_title: Résultats a long terme de la chimionucléolyse à la papaïne.